# Table S13: Multivariate Cox Regression — Full Adjusted Hazard Ratios
# Cohort: TCGA-LIHC complete cases (n=265; 78 events; AFP missing in 89/365 excluded)
# Method: lifelines CoxPHFitter(penalizer=0.01), Wald 95% CI
# Reference model: _recompute_multivar_cox_v2.py (v2 ENHANCED, definitive)
#
Section	Description	Model_Variables	N_Patients	N_Events	C_index	AIC	Penalizer	Variable	aHR	aHR_95%_CI	Coef	SE	Z_statistic	P_value
A	Primary model: binary high-risk vs low-risk group adjusted for clinicopathological covariates	risk_group + age + sex + tnm_stage + grade + afp	265	78	0.704	739.8	0.01							
	risk group							Risk Group	2.143	1.326–3.462	0.7621	0.2447	3.114	1.847e-03
	age 							Age Clinical	1.398	0.882–2.218	0.3352	0.2354	1.424	1.544e-01
	sex 							Sex Clinical	0.706	0.444–1.122	-0.3485	0.2365	-1.474	1.405e-01
	TNM stage							Tnm Stage	1.647	1.013–2.678	0.4991	0.2479	2.013	4.409e-02
	grade							Grade	1.443	0.914–2.277	0.3667	0.2328	1.575	1.152e-01
	afp							Serum AFP	0.978	0.586–1.633	-0.0224	0.2615	-0.086	9.319e-01
B	Sensitivity analysis: continuous risk score (z-standardized) + same covariates	risk_zscore + age + sex + tnm_stage + grade + afp	265	78	0.700	741.9	0.01							
	risk zscore							Risk Zscore	1.582	1.192–2.099	0.4582	0.1447	3.166	1.550e-03
	age 							Age Clinical	1.385	0.867–2.214	0.3256	0.2364	1.377	1.685e-01
	sex 							Sex Clinical	0.694	0.435–1.107	-0.3656	0.2369	-1.543	1.228e-01
	tnm stage							Tnm Stage	1.661	1.017–2.713	0.5075	0.2482	2.044	4.094e-02
	grade							Grade	1.451	0.918–2.293	0.3719	0.2327	1.599	1.100e-01
	afp							Serum AFP	0.982	0.588–1.640	-0.0183	0.2618	-0.070	9.443e-01