Rank Gene_Symbol Pathway_Category Function_in_Ferroptosis_HSR_Crosstalk In_Final_Signature In_TCGA_Dataset 1 ACSL4 Lipid remodeling Acyl-CoA synthetase long-chain 4 ✓ 2 AHSA1 Co-chaperone Activator of Hsp90 ATPase activity 1 ✓ 3 AKR1C1 Detoxification Aldo-keto reductase 1C1 ✓ 4 AKR1C2 Detoxification Aldo-keto reductase 1C2 ✓ 5 AKR1C3 Detoxification Aldo-keto reductase 1C3 ✓ 6 ALOX12 Lipid peroxidation Arachidonate 12-lipoxygenase ✓ 7 ALOX15 Lipid peroxidation Arachidonate 15-lipoxygenase ✓ 8 ATG5 Autophagy Autophagy related 5 ✓ 9 ATG7 Autophagy Autophagy related 7 ✓ 10 BAG3 Co-chaperone BAG cochaperone 3; CASA complex ✓ 11 BECN1 Autophagy Beclin 1; autophagy initiator ✓ 12 CCT2 TRiC/CCT Chaperonin containing TCP1 subunit 2 ✓ 13 CCT5 TRiC/CCT Chaperonin containing TCP1 subunit 5 ✓ 14 CCT8 TRiC/CCT Chaperonin containing TCP1 subunit 8 ✓ 15 CHAC1 GSH catabolism Glutathione-specific γ-glutamylcyclotransferase ✓ 16 CS TCA cycle Citrate synthase ✓ 17 DNAJA1 HSP40/DnaJ DnaJ homolog subfamily A member 1 ✓ 18 DNAJA3 HSP40/DnaJ DnaJ homolog subfamily A member 3 (Tid1) ✓ 19 DNAJA4 HSP40/DnaJ DnaJ homolog subfamily A member 4 ✓ 20 DNAJB1 HSP40/DnaJ DnaJ homolog subfamily B member 1 ✓ 21 DNAJB11 HSP40/DnaJ DnaJ homolog subfamily B member 11 ✓ 22 DNAJB2 HSP40/DnaJ DnaJ homolog subfamily B member 2 ✓ 23 DNAJB4 HSP40/DnaJ DnaJ homolog subfamily B member 4 ✓ 24 DNAJB6 HSP40/DnaJ DnaJ homolog subfamily B member 6 ✓ 25 DNAJC10 HSP40/DnaJ DnaJ homolog subfamily C member 10 ✓ 26 DNAJC12 HSP40/DnaJ DnaJ homolog subfamily C member 12 ✓ 27 DNAJC13 HSP40/DnaJ DnaJ homolog subfamily C member 13 ✓ 28 DNAJC19 HSP40/DnaJ DnaJ homolog subfamily C member 19 (mito) ✓ 29 DNAJC24 HSP40/DnaJ DnaJ homolog subfamily C member 24 ✓ 30 DNAJC7 HSP40/DnaJ DnaJ homolog subfamily C member 7 ✓ 31 DPP4 Protein regulation Dipeptidyl peptidase 4 ✓ 32 FDFT1 Cholesterol Farnesyl-diphosphate farnesyltransferase ✓ 33 FTH1 Iron metabolism Ferritin heavy chain; iron storage ✓ 34 FTL Iron metabolism Ferritin light chain; iron storage ✓ 35 GCLC GSH synthesis Glutamate-cysteine ligase catalytic ✓ 36 GCLM GSH synthesis Glutamate-cysteine ligase modifier ✓ 37 GLS2 Glutamine/Glutamate Glutaminase 2; glutamate production ✓ 38 GPX4 Glutathione/GPX4 Glutathione peroxidase 4; ferroptosis gatekeeper ✓ 39 GSS GSH synthesis Glutathione synthetase ✓ 40 HMOX1 Iron/heme Heme oxygenase-1; heme degradation ✓ 41 HSF1 HSF Heat shock factor 1; master regulator ✓ 42 HSF2 HSF Heat shock factor 2; developmental roles ✓ 43 HSP90AA1 HSP90α Heat shock 90α (inducible) ✓ 44 HSP90AB1 HSP90β Heat shock 90β (constitutive) ✓ 45 HSPA14 HSP70 Heat shock 70kDa protein 14 ✓ 46 HSPA1A HSP70 Heat shock 70kDa protein 1A (inducible) ✓ 47 HSPA1B HSP70 Heat shock 70kDa protein 1B ✓ 48 HSPA4 HSP70 Heat shock 70kDa protein 4 (apoptotic inhibitor) ✓ 49 HSPA5 HSP70/BiP GRP78; ER stress response ✓ 50 HSPA6 HSP70 Heat shock 70kDa protein 6 (neuronal) ✓ 51 HSPA8 HSC70 Heat shock cognate 71kDa (constitutive) ✓ 52 HSPA9 HSP70/morto Mortalin/GRP75; mitochondrial HSP70 ✓ 53 HSPB1 sHSP27 Heat shock protein 27; phosphorylation-regulated ✓ 54 HSPB2 sHSP Heat shock protein β-2 ✓ 55 HSPB6 sHSP20 Heat shock protein 20 ✓ 56 HSPB8 sHSP22/HSPB8 Heat shock protein B8; autophagy link ✓ 57 HSPD1 HSP60 Heat shock 60kDa (mitochondrial chaperonin) ✓ 58 HSPH1 HSP110 Heat shock 105kDa/110 (nucleotide exchange) ✓ 59 LPCAT3 Lipid remodeling Lysophosphatidylcholine acyltransferase 3 ✓ 60 MT1G Metal detox Metallothionein 1G ✓ 61 NCOA4 Iron metabolism Ferritinophagy cargo receptor ✓ 62 NFE2L2 Iron/lipid peroxide NRF2; antioxidant response TF ✓ 63 POR Iron/LPO Cytochrome P450 reductase ✓ 64 SAT1 Polyamine/LPO Polyamine oxidase; lipid peroxidation ✓ 65 SLC1A5 Amino acid transport ASCT2; neutral amino acid transporter ✓ 66 SLC2A1 Glucose metabolism GLUT1; glucose transporter ✓ Selected ✓ 67 SLC38A1 Amino acid transport SNAT1; glutamine transporter ✓ 68 SLC39A14 Zinc/iron transport ZIP14 ✓ 69 SLC3A2 Cystine/GSH import System Xc− heavy chain ✓ 70 SLC7A11 Cystine/GSH import System Xc− light chain; cystine importer ✓ Selected ✓ 71 SOD1 ROS scavenging Cu/Zn superoxide dismutase ✓ 72 SOD2 ROS scavenging Mn superoxide dismutase ✓ 73 STEAP3 Iron metabolism Metalloreductase; Fe3+→Fe2+ ✓ 74 TFAM Mitochondria/iron Mitochondrial transcription factor A ✓ 75 TFRC Iron metabolism Transferrin receptor; iron uptake ✓ 76 TP53_path p53 pathway p53 target genes (proxy) — 77 TRAP1 Mitochondrial HSP TNF receptor-associated protein 1 ✓ 78 VDAC3 Iron/mitochondria Voltage-dependent anion channel 3 ✓ 79 KEAP1 NRF2 regulation NRF2 negative regulator; ferroptosis sensitivity modulator via antioxidant response — 80 CISD1 Iron metabolism CDGSH iron-sulfur domain protein 1; mitochondrial iron export and ferroptosis regulation — 81 PHKG2 Glycogen metabolism Phosphorylase kinase regulatory subunit β; ferroptosis via glycogen-phosphorylase pathway — 82 HSPA2 HSP70 Heat shock 70kDa protein 2; HSP70 family (Kampinga & Craig nomenclature) ✓ 83 HSPB3 sHSP Heat shock protein β-3; small HSP family member (Kampinga & Craig nomenclature) —