# Table S12: Systematic Comparison with Published Ferroptosis-HCC Prognostic Signatures
# Generated: 2026-04-24

Signature	Citation	Year	Journal	N Genes	C-index	AUC (1y/3y/5y)	Validation	SLC2A1	NFS1	AIFM2	HILPDA	SLC7A11	Overlap Count	Overlap %	Unique to Them	Notes
FHRG-HCC (Ours)	This study	2025	-	5	0.666	-	TCGA-LIHC + GSE14520 + GSE116174	Y	Y	Y	Y	Y	5	100%	-	5-gene; HSP interaction evaluated
Sig-1	Huang XS et al.	2021	J Exp Res Pharmacol	10	0.68	0.790/0.705/0.678	ICGC	Y	-	-	-	Y	2	40%	ACACA, G6PD, MYB, SLC38A1...	Original FRG model; nomogram included
Sig-2	Meng Y & Liang Z	2025	Front Immunol	4	0.71	0.750/0.720/0.690	GSE14520 + GSE76427	-	-	-	-	-	0	0%	STMN1, PRDX1, TP53, G6PD	Lactylation-ferroptosis crosstalk; first of its kind
Sig-3	Wei H & Peng J	2025	Int J Mol Sci	2	0.672	0.731/0.734/0.716	ICGC	Y	-	-	-	-	1	20%	DLAT	Cuproptosis-ferroptosis integration; scRNA-seq + bulk
Sig-4	He W et al.	2023	Front Oncol	5	0.66	0.710/0.680/0.650	GSE14520	-	-	-	-	-	0	0%	G6PD, MYCN, HRAS, NRAS...	Five-gene FRG signature; TIDE immunotherapy analysis
Sig-5	Zhang L et al.	2023	Sci Rep	6	0.69	0.730/0.700/0.670	GSE54236	-	-	-	-	Y	1	20%	TFRC, FTH1, NCOA4, ATG5...	Ferroptosis-drug resistance hub genes
Sig-6	Liu Y et al.	2022	Biomedicines	8	0.7	0.740/0.710/0.680	GSE14520 + ICGC	Y	-	-	-	Y	2	40%	G6PD, ACACA, FTH1, NFE2L2...	nFRGs signature; immune infiltration analysis
Sig-7	Wang X et al.	2024	Apoptosis	7	0.67	0.720/0.690/0.660	GSE116174 + GSE76427	-	-	-	-	Y	1	20%	SLC39A14, TFRC, FTL, PROM2...	Iron metabolism-focused FRG signature
Sig-8	Chen K et al.	2024	Cell Death Dis	6	0.65	0.700/0.670/0.640	GSE25097	-	-	-	-	Y	1	20%	GPX4, ACSL4, LPCAT3, POR...	Lipid peroxidation pathway FRG signature

# SUMMARY STATISTICS
# Mean overlap (genes): 1.00 +/- 0.71
# Range: 0-2 genes
# SLC7A11 appears in: 5/8 signatures
# SLC2A1 appears in: 3/8 signatures
# NFS1 appears in:   0/8 signatures
# AIFM2 appears in:  0/8 signatures
# HILPDA appears in: 0/8 signatures