{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Sheet1"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":45,"n_cols":19,"rows_kept":45,"merged":[[0,0,0,18],[1,0,2,0],[1,1,2,1],[1,2,2,2],[1,3,2,3],[1,4,1,6],[1,7,2,7],[1,8,2,8],[1,9,2,9],[1,10,2,10],[1,11,2,11],[1,12,2,12],[1,13,2,13],[1,14,2,14],[1,15,2,15],[1,16,2,16],[1,17,2,17],[1,18,2,18],[4,0,6,0],[4,1,6,1],[4,2,6,2],[4,3,6,3],[4,7,6,7],[4,8,6,8],[4,9,6,9],[8,0,14,0],[8,1,14,1],[8,2,14,2],[8,3,14,3],[8,4,14,4],[8,5,14,5],[8,6,14,6],[8,7,14,7],[8,8,14,8],[8,9,14,9],[15,0,23,0],[15,1,23,1],[15,2,23,2],[15,3,23,3],[15,5,23,5],[15,7,23,7],[15,8,23,8],[15,9,23,9],[25,0,27,0],[25,1,27,1],[25,2,27,2],[25,3,27,3],[25,4,27,4],[25,5,27,5],[25,6,27,6],[25,7,27,7],[25,8,27,8],[25,9,27,9],[28,0,30,0],[28,1,30,1],[28,2,30,2],[28,3,30,3],[28,4,30,4],[28,5,30,5],[28,6,30,6],[28,7,30,7],[28,8,30,8],[28,9,30,9],[31,0,34,0],[31,1,34,1],[31,2,34,2],[31,3,34,3],[31,4,34,4],[31,5,34,5],[31,6,34,6],[31,7,34,7],[31,8,34,8],[31,9,34,9],[36,0,37,0],[36,1,37,1],[36,2,37,2],[36,3,37,3],[36,4,37,4],[36,5,37,5],[36,6,37,6],[36,7,37,7],[36,8,37,8],[36,9,37,9],[40,0,43,0],[40,1,43,1],[40,2,43,2],[40,3,43,3],[40,4,41,4],[40,6,41,6],[40,7,43,7],[40,8,43,8],[40,9,43,9],[42,4,43,4],[42,6,43,6],[44,0,44,18]],"flags":["formulas_cached_only"]}
["Table 1 Characteristics of 14 studies included in the meta-analysis"]
["NO","First author","Year","Country","Sample type",null,null,"Time of sampling","Sample size","Internal reference","ncRNAs","Level","TP","FP","TN","FN","SEN","SPE","AUC"]
[{"$nulls":4},"PE","Subgroup","Control"]
[1,"Elovitz[8]",2012,"USA",19,null,19,"15-17 weeks","serum","RNU86","miR-210 ","up",17,3,16,2,0.9,0.84,0.85]
[2,"Winger[9]",2015,"USA",12,null,19,"First trimester","PBMC","RNU48","7 miRNAs","up",10,2,17,2,0.833,0.895,0.9]
[{"$nulls":4},5,"EOPE",19,{"$nulls":3},"7 miRNAs","up",4,2,17,1,0.857,0.895,0.86]
[{"$nulls":4},7,"LOPE",19,{"$nulls":3},"7 miRNAs","up",6,2,17,1,0.8,0.895,0.92]
[3,"Zhang[10]",2017,"China",26,null,52,"12–20 weeks","plasma","U6","miR-942","down",17,16,36,9,0.654,0.692,0.718]
[4,"Hromadnikova[11]",2017,"Czech",21,null,58,"10–13 weeks","plasma","cel-miR-39","miR-517-5p","up",9,8,50,12,0.429,0.862,0.7]
[{"$nulls":10},"miR-516b-5p","up",8,9,49,13,0.381,0.845,0.608]
[{"$nulls":10},"miR-518b","up",11,21,37,10,0.524,0.638,0.55]
[{"$nulls":10},"miR-520a-5p","up",5,4,54,16,0.238,0.931,0.495]
[{"$nulls":10},"miR-520h","up",3,2,56,18,0.143,0.966,0.451]
[{"$nulls":10},"miR-525-5p","up",3,0,58,18,0.143,1,0.475]
[{"$nulls":10},"6 miRNAs",null,4,5,53,17,0.206,0.908,0.545]
[5,"Winger[12]",2018,"UK",8,null,40,"11–13 weeks","PBMC","NA","8 miRNAs",null,6,4,36,2,0.75,0.9,0.91]
[{"$nulls":4},4,null,19,{"$nulls":3},"miR-1267","NA",3,1,18,1,0.75,0.95,0.88]
[{"$nulls":4},2,null,7,{"$nulls":3},"miR-148a","NA",2,1,6,0,1,0.86,0.93]
[{"$nulls":4},2,null,4,{"$nulls":3},"miR-196a","NA",2,0,4,0,1,1,1]
[{"$nulls":4},3,null,8,{"$nulls":3},"miR-33a","NA",3,0,8,0,1,1,1]
[{"$nulls":4},3,null,9,{"$nulls":3},"miR-575","NA",3,2,7,0,1,0.78,0.93]
[{"$nulls":4},7,null,9,{"$nulls":3},"miR-582","NA",7,0,9,0,1,1,1]
[{"$nulls":4},3,null,14,{"$nulls":3},"miR-210","NA",2,0,14,1,0.67,1,0.86]
[{"$nulls":4},4,null,20,{"$nulls":3},"miR-16","NA",4,9,11,0,1,0.55,0.78]
[6,"Hu[13]",2018,"China",34,"EOPE",110,"24 weeks","blood","GAPDH","circ_0036877","down",29,30,80,5,0.853,0.727,0.846]
[7,"Jiang[14]",2018,"China",30,"EOPE",30,"before the 20th week","plasma","β-actin","circRNA_0001855","up",16,9,21,14,0.533,0.7,0.621]
[{"$nulls":10},"circRNA_0004904","up",16,9,21,14,0.533,0.7,0.611]
[{"$nulls":10},"PAPP-A + 2 circRNAs",null,26,1,29,4,0.867,0.967,0.94]
[8,"Bai[15]",2018,"China",30,"Severe PE",42,"14-19 weeks","plasma","GAPDH","circ_0007121","down",23,12,30,7,0.773,0.703,0.72]
[{"$nulls":10},"circ_0007121+ PlGF",null,21,6,36,9,0.7,0.867,0.8]
[{"$nulls":10},"circ_0007121+sFLT-1/PlGF",null,22,4,38,8,0.733,0.9,0.81]
[9,"Hromadnikova[16]",2019,"Czech",43,null,50,"10–13 weeks","plasmaexosomes","Cel-miR-39","miR-517-5p","down",26,15,35,17,0.605,0.7,0.634]
[{"$nulls":10},"miR-520a-5p","down",26,8,42,17,0.605,0.84,0.699]
[{"$nulls":10},"miR-525-5p","down",22,8,42,21,0.512,0.84,0.698]
[{"$nulls":10},"3 miRNAs","down",28,11,39,15,0.651,0.78,0.719]
[10,"Whigham[17]",2020,"Australia",34,"LOPE",196,"35- 37 weeks","PAXgene blood","miR191、SNORD44 SNORD48","2 miRNAs","down",15,20,176,19,0.45,0.9,0.79]
[11,"Zhang[18]",2020,"China",64,null,64,"8–20 weeks","plasma","GAPDH","MSP+circCRAMP1L","down",51,13,51,13,0.8,0.8,0.928]
[{"$nulls":10},"circCRAMP1L",null,41,17,47,23,0.64,0.74,0.813]
[12,"Chen[19]",2021,"China",24,"EOPE",30,"11–12 weeks","Plasma","18S rRNA","circ_0025992","up",13,2,28,11,0.542,0.933,0.8065]
[13,"Ahmed M[20]",2021,"Egypt",8,null,32,"14-26 weeks","plasma","NA","miR-210","up",7,10,22,1,0.875,0.688,0.852]
[14,"Zhao[21]",2021,"China",112,"mild PE",100,"15–16 weeks","serum","U6","miR-149-5p","down",95,45,55,17,0.848,0.55,0.727]
[{"$nulls":4},112,"mild PE",100,{"$nulls":3},"4-Hydroxyglutamate +miR-149-5p",null,95,32,68,17,0.848,0.68,0.844]
[{"$nulls":4},92,"severe PE",100,{"$nulls":3},"miR-149-5p","down",91,37,63,1,1.848,0.63,0.799]
[{"$nulls":4},92,"severe PE",100,{"$nulls":3},"4-Hydroxyglutamate and miR-149-5p",null,91,14,86,1,2.848,0.86,0.888]
["EOPE: Early onset preeclampsia, LOPE: Late onset preeclampsia; PBMC: Peripheral blood mononuclear cell;TP: true positive;FP: false positive; FN: false negative;TN: true negative; SEN: sensitivity; SPE: specificity; AUC: Area under curve; NA: Not available."]