{"text_format":"3","workbook":"xlsx","n_sheets":1,"sheets":["GESA_HALLMARK"],"read":"whole","date_system":"1900"}

{"sheet":"GESA_HALLMARK","index":0,"n_rows":52,"n_cols":9,"rows_kept":52}
["Table S3: GESA with HALLMARK gene sets of PRAD corhort in TCGA "]
["GS","SIZE","ES","NES","NOM p-val","FDR q-val","FWER p-val","RANK AT MAX","LEADING EDGE"]
["HALLMARK_G2M_CHECKPOINT",189,0.77989185,2.1928375,0,0.011176488,0.003,2649,"tags=76%, list=13%, signal=87%"]
["HALLMARK_E2F_TARGETS",195,0.8144554,2.1573713,0,0.007401081,0.005,1966,"tags=79%, list=10%, signal=87%"]
["HALLMARK_MYC_TARGETS_V1",194,0.7082519,1.923359,0,0.04351565,0.058,3872,"tags=73%, list=20%, signal=90%"]
["HALLMARK_SPERMATOGENESIS",133,0.4431057,1.8033935,0.0050083473,0.098235115,0.161,5853,"tags=34%, list=30%, signal=48%"]
["HALLMARK_MITOTIC_SPINDLE",198,0.5994982,1.7962378,0,0.08409659,0.17,5235,"tags=63%, list=27%, signal=85%"]
["HALLMARK_MYC_TARGETS_V2",58,0.69273484,1.7801782,0.024856597,0.08032324,0.186,2985,"tags=66%, list=15%, signal=77%"]
["HALLMARK_DNA_REPAIR",148,0.55121976,1.7774618,0.005597015,0.0697956,0.187,4619,"tags=48%, list=23%, signal=62%"]
["HALLMARK_MTORC1_SIGNALING",195,0.54472834,1.7344422,0.014842301,0.088736705,0.252,5634,"tags=59%, list=29%, signal=82%"]
["HALLMARK_PI3K_AKT_MTOR_SIGNALING",104,0.5076913,1.6976396,0.005586592,0.104253896,0.308,6013,"tags=55%, list=30%, signal=78%"]
["HALLMARK_UNFOLDED_PROTEIN_RESPONSE",107,0.5284457,1.6303884,0.020408163,0.14216027,0.401,5943,"tags=54%, list=30%, signal=77%"]
["HALLMARK_UV_RESPONSE_UP",154,0.3962642,1.5073049,0.046181172,0.26103204,0.593,6277,"tags=40%, list=32%, signal=59%"]
["HALLMARK_GLYCOLYSIS",198,0.38895935,1.4343523,0.09352518,0.34177607,0.677,7404,"tags=44%, list=37%, signal=70%"]
["HALLMARK_HEME_METABOLISM",192,0.37566906,1.3834289,0.0917603,0.3960778,0.725,8465,"tags=52%, list=43%, signal=89%"]
["HALLMARK_ALLOGRAFT_REJECTION",195,0.45471072,1.3238566,0.26418787,0.4669705,0.782,7563,"tags=58%, list=38%, signal=94%"]
["HALLMARK_PROTEIN_SECRETION",95,0.49277928,1.3139793,0.21621622,0.45660344,0.794,7027,"tags=65%, list=36%, signal=101%"]
["HALLMARK_WNT_BETA_CATENIN_SIGNALING",42,0.42472643,1.3024714,0.18283582,0.44398287,0.8,7629,"tags=52%, list=39%, signal=85%"]
["HALLMARK_PEROXISOME",104,0.3645472,1.2664145,0.18491921,0.47847202,0.824,6845,"tags=40%, list=35%, signal=61%"]
["HALLMARK_TGF_BETA_SIGNALING",54,0.41030654,1.186737,0.31060606,0.5936897,0.871,7797,"tags=57%, list=39%, signal=95%"]
["HALLMARK_INTERFERON_GAMMA_RESPONSE",198,0.4074267,1.184311,0.31462926,0.5670712,0.871,9267,"tags=66%, list=47%, signal=123%"]
["HALLMARK_IL2_STAT5_SIGNALING",195,0.33477822,1.173727,0.27788278,0.5575423,0.873,8558,"tags=49%, list=43%, signal=86%"]
["HALLMARK_OXIDATIVE_PHOSPHORYLATION",184,0.4091477,1.1398865,0.3745247,0.5877103,0.891,5063,"tags=36%, list=26%, signal=49%"]
["HALLMARK_ADIPOGENESIS",192,0.3282109,1.1324276,0.33086875,0.57270294,0.895,6226,"tags=36%, list=32%, signal=52%"]
["HALLMARK_INTERFERON_ALPHA_RESPONSE",95,0.41558132,1.1322274,0.38696536,0.5481097,0.895,9267,"tags=68%, list=47%, signal=128%"]
["HALLMARK_COMPLEMENT",200,0.30652308,1.0567442,0.4048964,0.6439169,0.919,6924,"tags=37%, list=35%, signal=56%"]
["HALLMARK_KRAS_SIGNALING_UP",194,0.30006978,1.0524029,0.39201453,0.6267034,0.922,8264,"tags=43%, list=42%, signal=74%"]
["HALLMARK_UV_RESPONSE_DN",138,0.32869044,1.0472722,0.43364486,0.6128482,0.925,8517,"tags=48%, list=43%, signal=83%"]
["HALLMARK_HEDGEHOG_SIGNALING",35,0.34047326,1.0403259,0.42242992,0.59980786,0.926,9852,"tags=54%, list=50%, signal=108%"]
["HALLMARK_INFLAMMATORY_RESPONSE",198,0.33465227,1.0388333,0.4470135,0.57985723,0.926,8596,"tags=47%, list=44%, signal=82%"]
["HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY",47,0.32786083,1.0302259,0.41941747,0.5720554,0.927,6102,"tags=36%, list=31%, signal=52%"]
["HALLMARK_CHOLESTEROL_HOMEOSTASIS",73,0.3077246,1.01696,0.43822393,0.57118803,0.934,8005,"tags=42%, list=41%, signal=71%"]
["HALLMARK_P53_PATHWAY",192,0.2732513,1.0160304,0.42698705,0.55456316,0.935,4382,"tags=22%, list=22%, signal=29%"]
["HALLMARK_APOPTOSIS",159,0.29408237,1.0158163,0.47758284,0.5376564,0.935,4960,"tags=24%, list=25%, signal=32%"]
["HALLMARK_IL6_JAK_STAT3_SIGNALING",87,0.34607974,1.0104342,0.4627451,0.5278037,0.938,9664,"tags=53%, list=49%, signal=103%"]
["HALLMARK_FATTY_ACID_METABOLISM",155,0.29200006,1.0023257,0.44765344,0.5229728,0.939,8418,"tags=43%, list=43%, signal=75%"]
["HALLMARK_HYPOXIA",191,0.26445714,1.0001395,0.47262773,0.5107726,0.94,9053,"tags=42%, list=46%, signal=78%"]
["HALLMARK_NOTCH_SIGNALING",32,0.31738034,0.9842523,0.4863884,0.51736766,0.947,8312,"tags=44%, list=42%, signal=75%"]
["HALLMARK_ANDROGEN_RESPONSE",96,0.33506435,0.97848916,0.5093985,0.50957865,0.947,9073,"tags=56%, list=46%, signal=104%"]
["HALLMARK_ANGIOGENESIS",36,0.3146032,0.95186824,0.4825046,0.5298026,0.953,7173,"tags=31%, list=36%, signal=48%"]
["HALLMARK_PANCREAS_BETA_CELLS",40,0.27327254,0.91162807,0.54651165,0.56501603,0.961,9208,"tags=45%, list=47%, signal=84%"]
["HALLMARK_ESTROGEN_RESPONSE_LATE",197,0.22150238,0.86615413,0.63736266,0.6053009,0.968,8707,"tags=38%, list=44%, signal=67%"]
["HALLMARK_APICAL_JUNCTION",194,0.23962101,0.8296168,0.66168225,0.6368642,0.976,8658,"tags=43%, list=44%, signal=76%"]
["HALLMARK_ESTROGEN_RESPONSE_EARLY",195,0.22046672,0.8239912,0.66003615,0.6281375,0.977,8705,"tags=42%, list=44%, signal=74%"]
["HALLMARK_TNFA_SIGNALING_VIA_NFKB",198,0.2402274,0.6767367,0.75967413,0.80669314,0.992,9073,"tags=41%, list=46%, signal=75%"]
["HALLMARK_BILE_ACID_METABOLISM",112,0.17811148,0.67466766,0.9155173,0.7910973,0.992,9039,"tags=39%, list=46%, signal=72%"]
["HALLMARK_APICAL_SURFACE",43,0.20008491,0.6531091,0.8655617,0.80033994,0.994,3848,"tags=14%, list=19%, signal=17%"]
["HALLMARK_MYOGENESIS",198,-0.40906903,-1.3390367,0.20079523,0.6431607,0.722,2792,"tags=51%, list=14%, signal=59%"]
["HALLMARK_KRAS_SIGNALING_DN",194,-0.17128119,-0.78293663,0.8280423,1,0.97,3033,"tags=30%, list=15%, signal=35%"]
["HALLMARK_XENOBIOTIC_METABOLISM",196,-0.16871773,-0.7406719,0.88235295,1,0.976,1114,"tags=15%, list=6%, signal=16%"]
["HALLMARK_COAGULATION",138,-0.13311188,-0.50454444,0.9825708,1,0.989,16237,"tags=99%, list=82%, signal=550%"]
["HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION",197,-0.13498873,-0.430047,0.95208335,0.9738149,0.989,2035,"tags=18%, list=10%, signal=20%"]