data_7EQ3
# 
_entry.id   7EQ3 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.397 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7EQ3         pdb_00007eq3 10.2210/pdb7eq3/pdb 
WWPDB D_1300022005 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2022-05-18 
2 'Structure model' 1 1 2023-11-29 
3 'Structure model' 1 2 2024-10-09 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'        
2 2 'Structure model' 'Refinement description' 
3 3 'Structure model' 'Structure summary'      
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' chem_comp_atom                
2 2 'Structure model' chem_comp_bond                
3 2 'Structure model' pdbx_initial_refinement_model 
4 3 'Structure model' pdbx_entry_details            
5 3 'Structure model' pdbx_modification_feature     
# 
_pdbx_audit_revision_item.ordinal             1 
_pdbx_audit_revision_item.revision_ordinal    3 
_pdbx_audit_revision_item.data_content_type   'Structure model' 
_pdbx_audit_revision_item.item                '_pdbx_entry_details.has_protein_modification' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        7EQ3 
_pdbx_database_status.recvd_initial_deposition_date   2021-04-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_audit_author.name               'Yan, L.' 
_audit_author.pdbx_ordinal       1 
_audit_author.identifier_ORCID   0000-0003-1775-5533 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Tall cytokine receptor signaling fine-tuning through dimer geometric reconstitution' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
_citation_author.citation_id        primary 
_citation_author.name               'Yan, L.' 
_citation_author.ordinal            1 
_citation_author.identifier_ORCID   0000-0003-1775-5533 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '9F8 diabody' 25014.916 1 ? ? ? ? 
2 non-polymer syn 'ACETATE ION' 59.044    1 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;AEVKLLESGPGLVAPSESLSITCTISGFSLTDDGVSWIRQPPGKGLEWLGVIWGGGSTYFNSLFKSRLSITRDNSKSQVF
LEMDSLQTDDTAMYYCAKHDGHETMDYWGQGTSVTVSSGGGGSEIVMTQSPKFMSTSIGDRVNITCKATQNVRTAVTWYQ
QKPGQSPQALIFLASNRHTGVPARFTGSGSGTDFTLTINNVKSEDLADYFCLQHWNYPLTFGSGTKLEIK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;AEVKLLESGPGLVAPSESLSITCTISGFSLTDDGVSWIRQPPGKGLEWLGVIWGGGSTYFNSLFKSRLSITRDNSKSQVF
LEMDSLQTDDTAMYYCAKHDGHETMDYWGQGTSVTVSSGGGGSEIVMTQSPKFMSTSIGDRVNITCKATQNVRTAVTWYQ
QKPGQSPQALIFLASNRHTGVPARFTGSGSGTDFTLTINNVKSEDLADYFCLQHWNYPLTFGSGTKLEIK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        'ACETATE ION' 
_pdbx_entity_nonpoly.comp_id     ACT 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   GLU n 
1 3   VAL n 
1 4   LYS n 
1 5   LEU n 
1 6   LEU n 
1 7   GLU n 
1 8   SER n 
1 9   GLY n 
1 10  PRO n 
1 11  GLY n 
1 12  LEU n 
1 13  VAL n 
1 14  ALA n 
1 15  PRO n 
1 16  SER n 
1 17  GLU n 
1 18  SER n 
1 19  LEU n 
1 20  SER n 
1 21  ILE n 
1 22  THR n 
1 23  CYS n 
1 24  THR n 
1 25  ILE n 
1 26  SER n 
1 27  GLY n 
1 28  PHE n 
1 29  SER n 
1 30  LEU n 
1 31  THR n 
1 32  ASP n 
1 33  ASP n 
1 34  GLY n 
1 35  VAL n 
1 36  SER n 
1 37  TRP n 
1 38  ILE n 
1 39  ARG n 
1 40  GLN n 
1 41  PRO n 
1 42  PRO n 
1 43  GLY n 
1 44  LYS n 
1 45  GLY n 
1 46  LEU n 
1 47  GLU n 
1 48  TRP n 
1 49  LEU n 
1 50  GLY n 
1 51  VAL n 
1 52  ILE n 
1 53  TRP n 
1 54  GLY n 
1 55  GLY n 
1 56  GLY n 
1 57  SER n 
1 58  THR n 
1 59  TYR n 
1 60  PHE n 
1 61  ASN n 
1 62  SER n 
1 63  LEU n 
1 64  PHE n 
1 65  LYS n 
1 66  SER n 
1 67  ARG n 
1 68  LEU n 
1 69  SER n 
1 70  ILE n 
1 71  THR n 
1 72  ARG n 
1 73  ASP n 
1 74  ASN n 
1 75  SER n 
1 76  LYS n 
1 77  SER n 
1 78  GLN n 
1 79  VAL n 
1 80  PHE n 
1 81  LEU n 
1 82  GLU n 
1 83  MET n 
1 84  ASP n 
1 85  SER n 
1 86  LEU n 
1 87  GLN n 
1 88  THR n 
1 89  ASP n 
1 90  ASP n 
1 91  THR n 
1 92  ALA n 
1 93  MET n 
1 94  TYR n 
1 95  TYR n 
1 96  CYS n 
1 97  ALA n 
1 98  LYS n 
1 99  HIS n 
1 100 ASP n 
1 101 GLY n 
1 102 HIS n 
1 103 GLU n 
1 104 THR n 
1 105 MET n 
1 106 ASP n 
1 107 TYR n 
1 108 TRP n 
1 109 GLY n 
1 110 GLN n 
1 111 GLY n 
1 112 THR n 
1 113 SER n 
1 114 VAL n 
1 115 THR n 
1 116 VAL n 
1 117 SER n 
1 118 SER n 
1 119 GLY n 
1 120 GLY n 
1 121 GLY n 
1 122 GLY n 
1 123 SER n 
1 124 GLU n 
1 125 ILE n 
1 126 VAL n 
1 127 MET n 
1 128 THR n 
1 129 GLN n 
1 130 SER n 
1 131 PRO n 
1 132 LYS n 
1 133 PHE n 
1 134 MET n 
1 135 SER n 
1 136 THR n 
1 137 SER n 
1 138 ILE n 
1 139 GLY n 
1 140 ASP n 
1 141 ARG n 
1 142 VAL n 
1 143 ASN n 
1 144 ILE n 
1 145 THR n 
1 146 CYS n 
1 147 LYS n 
1 148 ALA n 
1 149 THR n 
1 150 GLN n 
1 151 ASN n 
1 152 VAL n 
1 153 ARG n 
1 154 THR n 
1 155 ALA n 
1 156 VAL n 
1 157 THR n 
1 158 TRP n 
1 159 TYR n 
1 160 GLN n 
1 161 GLN n 
1 162 LYS n 
1 163 PRO n 
1 164 GLY n 
1 165 GLN n 
1 166 SER n 
1 167 PRO n 
1 168 GLN n 
1 169 ALA n 
1 170 LEU n 
1 171 ILE n 
1 172 PHE n 
1 173 LEU n 
1 174 ALA n 
1 175 SER n 
1 176 ASN n 
1 177 ARG n 
1 178 HIS n 
1 179 THR n 
1 180 GLY n 
1 181 VAL n 
1 182 PRO n 
1 183 ALA n 
1 184 ARG n 
1 185 PHE n 
1 186 THR n 
1 187 GLY n 
1 188 SER n 
1 189 GLY n 
1 190 SER n 
1 191 GLY n 
1 192 THR n 
1 193 ASP n 
1 194 PHE n 
1 195 THR n 
1 196 LEU n 
1 197 THR n 
1 198 ILE n 
1 199 ASN n 
1 200 ASN n 
1 201 VAL n 
1 202 LYS n 
1 203 SER n 
1 204 GLU n 
1 205 ASP n 
1 206 LEU n 
1 207 ALA n 
1 208 ASP n 
1 209 TYR n 
1 210 PHE n 
1 211 CYS n 
1 212 LEU n 
1 213 GLN n 
1 214 HIS n 
1 215 TRP n 
1 216 ASN n 
1 217 TYR n 
1 218 PRO n 
1 219 LEU n 
1 220 THR n 
1 221 PHE n 
1 222 GLY n 
1 223 SER n 
1 224 GLY n 
1 225 THR n 
1 226 LYS n 
1 227 LEU n 
1 228 GLU n 
1 229 ILE n 
1 230 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   230 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Mus musculus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     10090 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACT non-polymer         . 'ACETATE ION'   ? 'C2 H3 O2 -1'    59.044  
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   0   ?   ?   ?   A . n 
A 1 2   GLU 2   1   1   GLU GLU A . n 
A 1 3   VAL 3   2   2   VAL VAL A . n 
A 1 4   LYS 4   3   3   LYS LYS A . n 
A 1 5   LEU 5   4   4   LEU LEU A . n 
A 1 6   LEU 6   5   5   LEU LEU A . n 
A 1 7   GLU 7   6   6   GLU GLU A . n 
A 1 8   SER 8   7   7   SER SER A . n 
A 1 9   GLY 9   8   8   GLY GLY A . n 
A 1 10  PRO 10  9   9   PRO PRO A . n 
A 1 11  GLY 11  10  10  GLY GLY A . n 
A 1 12  LEU 12  11  11  LEU LEU A . n 
A 1 13  VAL 13  12  12  VAL VAL A . n 
A 1 14  ALA 14  13  13  ALA ALA A . n 
A 1 15  PRO 15  14  14  PRO PRO A . n 
A 1 16  SER 16  15  15  SER SER A . n 
A 1 17  GLU 17  16  16  GLU GLU A . n 
A 1 18  SER 18  17  17  SER SER A . n 
A 1 19  LEU 19  18  18  LEU LEU A . n 
A 1 20  SER 20  19  19  SER SER A . n 
A 1 21  ILE 21  20  20  ILE ILE A . n 
A 1 22  THR 22  21  21  THR THR A . n 
A 1 23  CYS 23  22  22  CYS CYS A . n 
A 1 24  THR 24  23  23  THR THR A . n 
A 1 25  ILE 25  24  24  ILE ILE A . n 
A 1 26  SER 26  25  25  SER SER A . n 
A 1 27  GLY 27  26  26  GLY GLY A . n 
A 1 28  PHE 28  27  27  PHE PHE A . n 
A 1 29  SER 29  28  28  SER SER A . n 
A 1 30  LEU 30  29  29  LEU LEU A . n 
A 1 31  THR 31  30  30  THR THR A . n 
A 1 32  ASP 32  31  31  ASP ASP A . n 
A 1 33  ASP 33  32  32  ASP ASP A . n 
A 1 34  GLY 34  33  33  GLY GLY A . n 
A 1 35  VAL 35  34  34  VAL VAL A . n 
A 1 36  SER 36  35  35  SER SER A . n 
A 1 37  TRP 37  36  36  TRP TRP A . n 
A 1 38  ILE 38  37  37  ILE ILE A . n 
A 1 39  ARG 39  38  38  ARG ARG A . n 
A 1 40  GLN 40  39  39  GLN GLN A . n 
A 1 41  PRO 41  40  40  PRO PRO A . n 
A 1 42  PRO 42  41  41  PRO PRO A . n 
A 1 43  GLY 43  42  42  GLY GLY A . n 
A 1 44  LYS 44  43  43  LYS LYS A . n 
A 1 45  GLY 45  44  44  GLY GLY A . n 
A 1 46  LEU 46  45  45  LEU LEU A . n 
A 1 47  GLU 47  46  46  GLU GLU A . n 
A 1 48  TRP 48  47  47  TRP TRP A . n 
A 1 49  LEU 49  48  48  LEU LEU A . n 
A 1 50  GLY 50  49  49  GLY GLY A . n 
A 1 51  VAL 51  50  50  VAL VAL A . n 
A 1 52  ILE 52  51  51  ILE ILE A . n 
A 1 53  TRP 53  52  52  TRP TRP A . n 
A 1 54  GLY 54  53  53  GLY GLY A . n 
A 1 55  GLY 55  54  54  GLY GLY A . n 
A 1 56  GLY 56  55  55  GLY GLY A . n 
A 1 57  SER 57  56  56  SER SER A . n 
A 1 58  THR 58  57  57  THR THR A . n 
A 1 59  TYR 59  58  58  TYR TYR A . n 
A 1 60  PHE 60  59  59  PHE PHE A . n 
A 1 61  ASN 61  60  60  ASN ASN A . n 
A 1 62  SER 62  61  61  SER SER A . n 
A 1 63  LEU 63  62  62  LEU LEU A . n 
A 1 64  PHE 64  63  63  PHE PHE A . n 
A 1 65  LYS 65  64  64  LYS LYS A . n 
A 1 66  SER 66  65  65  SER SER A . n 
A 1 67  ARG 67  66  66  ARG ARG A . n 
A 1 68  LEU 68  67  67  LEU LEU A . n 
A 1 69  SER 69  68  68  SER SER A . n 
A 1 70  ILE 70  69  69  ILE ILE A . n 
A 1 71  THR 71  70  70  THR THR A . n 
A 1 72  ARG 72  71  71  ARG ARG A . n 
A 1 73  ASP 73  72  72  ASP ASP A . n 
A 1 74  ASN 74  73  73  ASN ASN A . n 
A 1 75  SER 75  74  74  SER SER A . n 
A 1 76  LYS 76  75  75  LYS LYS A . n 
A 1 77  SER 77  76  76  SER SER A . n 
A 1 78  GLN 78  77  77  GLN GLN A . n 
A 1 79  VAL 79  78  78  VAL VAL A . n 
A 1 80  PHE 80  79  79  PHE PHE A . n 
A 1 81  LEU 81  80  80  LEU LEU A . n 
A 1 82  GLU 82  81  81  GLU GLU A . n 
A 1 83  MET 83  82  82  MET MET A . n 
A 1 84  ASP 84  83  83  ASP ASP A . n 
A 1 85  SER 85  84  84  SER SER A . n 
A 1 86  LEU 86  85  85  LEU LEU A . n 
A 1 87  GLN 87  86  86  GLN GLN A . n 
A 1 88  THR 88  87  87  THR THR A . n 
A 1 89  ASP 89  88  88  ASP ASP A . n 
A 1 90  ASP 90  89  89  ASP ASP A . n 
A 1 91  THR 91  90  90  THR THR A . n 
A 1 92  ALA 92  91  91  ALA ALA A . n 
A 1 93  MET 93  92  92  MET MET A . n 
A 1 94  TYR 94  93  93  TYR TYR A . n 
A 1 95  TYR 95  94  94  TYR TYR A . n 
A 1 96  CYS 96  95  95  CYS CYS A . n 
A 1 97  ALA 97  96  96  ALA ALA A . n 
A 1 98  LYS 98  97  97  LYS LYS A . n 
A 1 99  HIS 99  98  98  HIS HIS A . n 
A 1 100 ASP 100 99  99  ASP ASP A . n 
A 1 101 GLY 101 100 100 GLY GLY A . n 
A 1 102 HIS 102 101 101 HIS HIS A . n 
A 1 103 GLU 103 102 102 GLU GLU A . n 
A 1 104 THR 104 103 103 THR THR A . n 
A 1 105 MET 105 104 104 MET MET A . n 
A 1 106 ASP 106 105 105 ASP ASP A . n 
A 1 107 TYR 107 106 106 TYR TYR A . n 
A 1 108 TRP 108 107 107 TRP TRP A . n 
A 1 109 GLY 109 108 108 GLY GLY A . n 
A 1 110 GLN 110 109 109 GLN GLN A . n 
A 1 111 GLY 111 110 110 GLY GLY A . n 
A 1 112 THR 112 111 111 THR THR A . n 
A 1 113 SER 113 112 112 SER SER A . n 
A 1 114 VAL 114 113 113 VAL VAL A . n 
A 1 115 THR 115 114 114 THR THR A . n 
A 1 116 VAL 116 115 115 VAL VAL A . n 
A 1 117 SER 117 116 116 SER SER A . n 
A 1 118 SER 118 117 117 SER SER A . n 
A 1 119 GLY 119 118 118 GLY GLY A . n 
A 1 120 GLY 120 119 119 GLY GLY A . n 
A 1 121 GLY 121 120 120 GLY GLY A . n 
A 1 122 GLY 122 121 121 GLY GLY A . n 
A 1 123 SER 123 122 122 SER SER A . n 
A 1 124 GLU 124 123 123 GLU GLU A . n 
A 1 125 ILE 125 124 124 ILE ILE A . n 
A 1 126 VAL 126 125 125 VAL VAL A . n 
A 1 127 MET 127 126 126 MET MET A . n 
A 1 128 THR 128 127 127 THR THR A . n 
A 1 129 GLN 129 128 128 GLN GLN A . n 
A 1 130 SER 130 129 129 SER SER A . n 
A 1 131 PRO 131 130 130 PRO PRO A . n 
A 1 132 LYS 132 131 131 LYS LYS A . n 
A 1 133 PHE 133 132 132 PHE ALA A . n 
A 1 134 MET 134 133 133 MET MET A . n 
A 1 135 SER 135 134 134 SER SER A . n 
A 1 136 THR 136 135 135 THR THR A . n 
A 1 137 SER 137 136 136 SER SER A . n 
A 1 138 ILE 138 137 137 ILE ILE A . n 
A 1 139 GLY 139 138 138 GLY GLY A . n 
A 1 140 ASP 140 139 139 ASP ASP A . n 
A 1 141 ARG 141 140 140 ARG ARG A . n 
A 1 142 VAL 142 141 141 VAL VAL A . n 
A 1 143 ASN 143 142 142 ASN ASN A . n 
A 1 144 ILE 144 143 143 ILE ILE A . n 
A 1 145 THR 145 144 144 THR THR A . n 
A 1 146 CYS 146 145 145 CYS CYS A . n 
A 1 147 LYS 147 146 146 LYS LYS A . n 
A 1 148 ALA 148 147 147 ALA ALA A . n 
A 1 149 THR 149 148 148 THR THR A . n 
A 1 150 GLN 150 149 149 GLN GLN A . n 
A 1 151 ASN 151 150 150 ASN ASN A . n 
A 1 152 VAL 152 151 151 VAL VAL A . n 
A 1 153 ARG 153 152 152 ARG ARG A . n 
A 1 154 THR 154 153 153 THR THR A . n 
A 1 155 ALA 155 154 154 ALA ALA A . n 
A 1 156 VAL 156 155 155 VAL VAL A . n 
A 1 157 THR 157 156 156 THR THR A . n 
A 1 158 TRP 158 157 157 TRP TRP A . n 
A 1 159 TYR 159 158 158 TYR TYR A . n 
A 1 160 GLN 160 159 159 GLN GLN A . n 
A 1 161 GLN 161 160 160 GLN GLN A . n 
A 1 162 LYS 162 161 161 LYS LYS A . n 
A 1 163 PRO 163 162 162 PRO PRO A . n 
A 1 164 GLY 164 163 163 GLY GLY A . n 
A 1 165 GLN 165 164 164 GLN GLN A . n 
A 1 166 SER 166 165 165 SER SER A . n 
A 1 167 PRO 167 166 166 PRO PRO A . n 
A 1 168 GLN 168 167 167 GLN GLN A . n 
A 1 169 ALA 169 168 168 ALA ALA A . n 
A 1 170 LEU 170 169 169 LEU LEU A . n 
A 1 171 ILE 171 170 170 ILE ILE A . n 
A 1 172 PHE 172 171 171 PHE PHE A . n 
A 1 173 LEU 173 172 172 LEU LEU A . n 
A 1 174 ALA 174 173 173 ALA ALA A . n 
A 1 175 SER 175 174 174 SER SER A . n 
A 1 176 ASN 176 175 175 ASN ASN A . n 
A 1 177 ARG 177 176 176 ARG ARG A . n 
A 1 178 HIS 178 177 177 HIS HIS A . n 
A 1 179 THR 179 178 178 THR THR A . n 
A 1 180 GLY 180 179 179 GLY GLY A . n 
A 1 181 VAL 181 180 180 VAL VAL A . n 
A 1 182 PRO 182 181 181 PRO PRO A . n 
A 1 183 ALA 183 182 182 ALA ALA A . n 
A 1 184 ARG 184 183 183 ARG ARG A . n 
A 1 185 PHE 185 184 184 PHE PHE A . n 
A 1 186 THR 186 185 185 THR THR A . n 
A 1 187 GLY 187 186 186 GLY GLY A . n 
A 1 188 SER 188 187 187 SER SER A . n 
A 1 189 GLY 189 188 188 GLY GLY A . n 
A 1 190 SER 190 189 189 SER SER A . n 
A 1 191 GLY 191 190 190 GLY GLY A . n 
A 1 192 THR 192 191 191 THR THR A . n 
A 1 193 ASP 193 192 192 ASP ASP A . n 
A 1 194 PHE 194 193 193 PHE PHE A . n 
A 1 195 THR 195 194 194 THR THR A . n 
A 1 196 LEU 196 195 195 LEU LEU A . n 
A 1 197 THR 197 196 196 THR THR A . n 
A 1 198 ILE 198 197 197 ILE ILE A . n 
A 1 199 ASN 199 198 198 ASN ASN A . n 
A 1 200 ASN 200 199 199 ASN ASN A . n 
A 1 201 VAL 201 200 200 VAL VAL A . n 
A 1 202 LYS 202 201 201 LYS LYS A . n 
A 1 203 SER 203 202 202 SER SER A . n 
A 1 204 GLU 204 203 203 GLU GLU A . n 
A 1 205 ASP 205 204 204 ASP ASP A . n 
A 1 206 LEU 206 205 205 LEU LEU A . n 
A 1 207 ALA 207 206 206 ALA ALA A . n 
A 1 208 ASP 208 207 207 ASP ASP A . n 
A 1 209 TYR 209 208 208 TYR TYR A . n 
A 1 210 PHE 210 209 209 PHE PHE A . n 
A 1 211 CYS 211 210 210 CYS CYS A . n 
A 1 212 LEU 212 211 211 LEU LEU A . n 
A 1 213 GLN 213 212 212 GLN GLN A . n 
A 1 214 HIS 214 213 213 HIS HIS A . n 
A 1 215 TRP 215 214 214 TRP TRP A . n 
A 1 216 ASN 216 215 215 ASN ASN A . n 
A 1 217 TYR 217 216 216 TYR TYR A . n 
A 1 218 PRO 218 217 217 PRO PRO A . n 
A 1 219 LEU 219 218 218 LEU LEU A . n 
A 1 220 THR 220 219 219 THR THR A . n 
A 1 221 PHE 221 220 220 PHE PHE A . n 
A 1 222 GLY 222 221 221 GLY GLY A . n 
A 1 223 SER 223 222 222 SER SER A . n 
A 1 224 GLY 224 223 223 GLY GLY A . n 
A 1 225 THR 225 224 224 THR THR A . n 
A 1 226 LYS 226 225 225 LYS LYS A . n 
A 1 227 LEU 227 226 226 LEU LEU A . n 
A 1 228 GLU 228 227 227 GLU GLU A . n 
A 1 229 ILE 229 228 228 ILE ILE A . n 
A 1 230 LYS 230 229 229 LYS LYS A . n 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          ACT 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     301 
_pdbx_nonpoly_scheme.auth_seq_num    1 
_pdbx_nonpoly_scheme.pdb_mon_id      ACT 
_pdbx_nonpoly_scheme.auth_mon_id     ACT 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A PHE 132 ? CG  ? A PHE 133 CG  
2 1 Y 1 A PHE 132 ? CD1 ? A PHE 133 CD1 
3 1 Y 1 A PHE 132 ? CD2 ? A PHE 133 CD2 
4 1 Y 1 A PHE 132 ? CE1 ? A PHE 133 CE1 
5 1 Y 1 A PHE 132 ? CE2 ? A PHE 133 CE2 
6 1 Y 1 A PHE 132 ? CZ  ? A PHE 133 CZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? HKL-2000    ? ? ? .           1 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.17.1_3660 2 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.27        3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     7EQ3 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     106.806 
_cell.length_a_esd                 ? 
_cell.length_b                     106.806 
_cell.length_b_esd                 ? 
_cell.length_c                     50.020 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
# 
_symmetry.entry_id                         7EQ3 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   7EQ3 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                      ? 
_exptl_crystal.density_diffrn              ? 
_exptl_crystal.density_Matthews            3.27 
_exptl_crystal.density_method              ? 
_exptl_crystal.density_percent_sol         62.41 
_exptl_crystal.description                 ? 
_exptl_crystal.F_000                       ? 
_exptl_crystal.id                          1 
_exptl_crystal.preparation                 ? 
_exptl_crystal.size_max                    ? 
_exptl_crystal.size_mid                    ? 
_exptl_crystal.size_min                    ? 
_exptl_crystal.size_rad                    ? 
_exptl_crystal.colour_lustre               ? 
_exptl_crystal.colour_modifier             ? 
_exptl_crystal.colour_primary              ? 
_exptl_crystal.density_meas                ? 
_exptl_crystal.density_meas_esd            ? 
_exptl_crystal.density_meas_gt             ? 
_exptl_crystal.density_meas_lt             ? 
_exptl_crystal.density_meas_temp           ? 
_exptl_crystal.density_meas_temp_esd       ? 
_exptl_crystal.density_meas_temp_gt        ? 
_exptl_crystal.density_meas_temp_lt        ? 
_exptl_crystal.pdbx_crystal_image_url      ? 
_exptl_crystal.pdbx_crystal_image_format   ? 
_exptl_crystal.pdbx_mosaicity              ? 
_exptl_crystal.pdbx_mosaicity_esd          ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp            293 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Tris pH 8.0, 0.2M Ammonium acetate and 16% PEG 10000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     'IMAGE PLATE' 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU RAXIS IV++' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-09-15 
_diffrn_detector.pdbx_frequency               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.5406 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.5406 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       7EQ3 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.87 
_reflns.d_resolution_low                               46.25 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     7564 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           91.3 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                8.9 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.7 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.75 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.87 
_reflns_shell.d_res_low                                     2.98 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             621 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.6 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                110.710 
_refine.B_iso_mean                               47.9912 
_refine.B_iso_min                                22.800 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 7EQ3 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.8700 
_refine.ls_d_res_low                             46.2500 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     7561 
_refine.ls_number_reflns_R_free                  384 
_refine.ls_number_reflns_R_work                  7177 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.1100 
_refine.ls_percent_reflns_R_free                 5.0800 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2384 
_refine.ls_R_factor_R_free                       0.247 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2381 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.360 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      3V6O 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.0100 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.4200 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         final 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.8700 
_refine_hist.d_res_low                        46.2500 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               1746 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       229 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1746 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.8700 
_refine_ls_shell.d_res_low                        3.2900 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             108 
_refine_ls_shell.number_reflns_R_work             2272 
_refine_ls_shell.percent_reflns_obs               94.0000 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free                  0.3951 
_refine_ls_shell.R_factor_R_free_error            0.0000 
_refine_ls_shell.R_factor_R_work                  0.3191 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
# 
_struct.entry_id                     7EQ3 
_struct.title                        'Apo diabody form of CRH2-directed antibody 9F8' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        7EQ3 
_struct_keywords.text            'Leptin receptor, antagonist, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    7EQ3 
_struct_ref.pdbx_db_accession          7EQ3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7EQ3 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 230 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             7EQ3 
_struct_ref_seq.db_align_beg                  0 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  229 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       0 
_struct_ref_seq.pdbx_auth_seq_align_end       229 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 230   ? 
1 MORE         -0    ? 
1 'SSA (A^2)'  11950 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 PHE A 64  ? SER A 66  ? PHE A 63  SER A 65  5 ? 3 
HELX_P HELX_P2 AA2 GLN A 87  ? THR A 91  ? GLN A 86  THR A 90  5 ? 5 
HELX_P HELX_P3 AA3 LYS A 202 ? LEU A 206 ? LYS A 201 LEU A 205 5 ? 5 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 23  SG ? ? ? 1_555 A CYS 96  SG ? ? A CYS 22  A CYS 95  1_555 ? ? ? ? ? ? ? 2.032 ? ? 
disulf2 disulf ? ? A CYS 146 SG ? ? ? 1_555 A CYS 211 SG ? ? A CYS 145 A CYS 210 1_555 ? ? ? ? ? ? ? 1.912 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 23  ? CYS A 96  ? CYS A 22  ? 1_555 CYS A 95  ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 146 ? CYS A 211 ? CYS A 145 ? 1_555 CYS A 210 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 SER 130 A . ? SER 129 A PRO 131 A ? PRO 130 A 1 4.00  
2 TYR 217 A . ? TYR 216 A PRO 218 A ? PRO 217 A 1 -3.53 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 6 ? 
AA6 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LYS A 4   ? SER A 8   ? LYS A 3   SER A 7   
AA1 2 LEU A 19  ? SER A 26  ? LEU A 18  SER A 25  
AA1 3 GLN A 78  ? MET A 83  ? GLN A 77  MET A 82  
AA1 4 LEU A 68  ? ASP A 73  ? LEU A 67  ASP A 72  
AA2 1 LEU A 12  ? VAL A 13  ? LEU A 11  VAL A 12  
AA2 2 THR A 112 ? VAL A 116 ? THR A 111 VAL A 115 
AA2 3 ALA A 92  ? HIS A 99  ? ALA A 91  HIS A 98  
AA2 4 VAL A 35  ? GLN A 40  ? VAL A 34  GLN A 39  
AA2 5 GLU A 47  ? ILE A 52  ? GLU A 46  ILE A 51  
AA2 6 THR A 58  ? PHE A 60  ? THR A 57  PHE A 59  
AA3 1 LEU A 12  ? VAL A 13  ? LEU A 11  VAL A 12  
AA3 2 THR A 112 ? VAL A 116 ? THR A 111 VAL A 115 
AA3 3 ALA A 92  ? HIS A 99  ? ALA A 91  HIS A 98  
AA3 4 MET A 105 ? TRP A 108 ? MET A 104 TRP A 107 
AA4 1 MET A 127 ? SER A 130 ? MET A 126 SER A 129 
AA4 2 VAL A 142 ? ALA A 148 ? VAL A 141 ALA A 147 
AA4 3 ASP A 193 ? ILE A 198 ? ASP A 192 ILE A 197 
AA4 4 PHE A 185 ? GLY A 189 ? PHE A 184 GLY A 188 
AA5 1 PHE A 133 ? THR A 136 ? PHE A 132 THR A 135 
AA5 2 THR A 225 ? ILE A 229 ? THR A 224 ILE A 228 
AA5 3 ASP A 208 ? GLN A 213 ? ASP A 207 GLN A 212 
AA5 4 VAL A 156 ? GLN A 161 ? VAL A 155 GLN A 160 
AA5 5 GLN A 168 ? PHE A 172 ? GLN A 167 PHE A 171 
AA5 6 ASN A 176 ? ARG A 177 ? ASN A 175 ARG A 176 
AA6 1 PHE A 133 ? THR A 136 ? PHE A 132 THR A 135 
AA6 2 THR A 225 ? ILE A 229 ? THR A 224 ILE A 228 
AA6 3 ASP A 208 ? GLN A 213 ? ASP A 207 GLN A 212 
AA6 4 THR A 220 ? PHE A 221 ? THR A 219 PHE A 220 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LYS A 4   ? N LYS A 3   O SER A 26  ? O SER A 25  
AA1 2 3 N CYS A 23  ? N CYS A 22  O VAL A 79  ? O VAL A 78  
AA1 3 4 O PHE A 80  ? O PHE A 79  N THR A 71  ? N THR A 70  
AA2 1 2 N VAL A 13  ? N VAL A 12  O THR A 115 ? O THR A 114 
AA2 2 3 O THR A 112 ? O THR A 111 N TYR A 94  ? N TYR A 93  
AA2 3 4 O TYR A 95  ? O TYR A 94  N ILE A 38  ? N ILE A 37  
AA2 4 5 N TRP A 37  ? N TRP A 36  O LEU A 49  ? O LEU A 48  
AA2 5 6 N VAL A 51  ? N VAL A 50  O TYR A 59  ? O TYR A 58  
AA3 1 2 N VAL A 13  ? N VAL A 12  O THR A 115 ? O THR A 114 
AA3 2 3 O THR A 112 ? O THR A 111 N TYR A 94  ? N TYR A 93  
AA3 3 4 N LYS A 98  ? N LYS A 97  O TYR A 107 ? O TYR A 106 
AA4 1 2 N THR A 128 ? N THR A 127 O LYS A 147 ? O LYS A 146 
AA4 2 3 N ILE A 144 ? N ILE A 143 O LEU A 196 ? O LEU A 195 
AA4 3 4 O THR A 197 ? O THR A 196 N THR A 186 ? N THR A 185 
AA5 1 2 N THR A 136 ? N THR A 135 O GLU A 228 ? O GLU A 227 
AA5 2 3 O THR A 225 ? O THR A 224 N TYR A 209 ? N TYR A 208 
AA5 3 4 O PHE A 210 ? O PHE A 209 N TYR A 159 ? N TYR A 158 
AA5 4 5 N TRP A 158 ? N TRP A 157 O LEU A 170 ? O LEU A 169 
AA5 5 6 N PHE A 172 ? N PHE A 171 O ASN A 176 ? O ASN A 175 
AA6 1 2 N THR A 136 ? N THR A 135 O GLU A 228 ? O GLU A 227 
AA6 2 3 O THR A 225 ? O THR A 224 N TYR A 209 ? N TYR A 208 
AA6 3 4 N GLN A 213 ? N GLN A 212 O THR A 220 ? O THR A 219 
# 
_pdbx_entry_details.entry_id                   7EQ3 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 15  ? ? 80.72   -3.99   
2 1 LYS A 64  ? ? 37.00   -64.12  
3 1 HIS A 101 ? ? -158.71 2.54    
4 1 GLU A 102 ? ? -102.55 -69.87  
5 1 ILE A 124 ? ? 72.92   114.04  
6 1 ARG A 152 ? ? 55.50   -114.03 
7 1 ALA A 173 ? ? 70.36   -47.04  
8 1 ALA A 206 ? ? -165.24 -168.18 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A ALA 0   ? A ALA 1 
2 1 N 0 A ACT 301 ? B ACT ? 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACT C    C N N 1   
ACT O    O N N 2   
ACT OXT  O N N 3   
ACT CH3  C N N 4   
ACT H1   H N N 5   
ACT H2   H N N 6   
ACT H3   H N N 7   
ALA N    N N N 8   
ALA CA   C N S 9   
ALA C    C N N 10  
ALA O    O N N 11  
ALA CB   C N N 12  
ALA OXT  O N N 13  
ALA H    H N N 14  
ALA H2   H N N 15  
ALA HA   H N N 16  
ALA HB1  H N N 17  
ALA HB2  H N N 18  
ALA HB3  H N N 19  
ALA HXT  H N N 20  
ARG N    N N N 21  
ARG CA   C N S 22  
ARG C    C N N 23  
ARG O    O N N 24  
ARG CB   C N N 25  
ARG CG   C N N 26  
ARG CD   C N N 27  
ARG NE   N N N 28  
ARG CZ   C N N 29  
ARG NH1  N N N 30  
ARG NH2  N N N 31  
ARG OXT  O N N 32  
ARG H    H N N 33  
ARG H2   H N N 34  
ARG HA   H N N 35  
ARG HB2  H N N 36  
ARG HB3  H N N 37  
ARG HG2  H N N 38  
ARG HG3  H N N 39  
ARG HD2  H N N 40  
ARG HD3  H N N 41  
ARG HE   H N N 42  
ARG HH11 H N N 43  
ARG HH12 H N N 44  
ARG HH21 H N N 45  
ARG HH22 H N N 46  
ARG HXT  H N N 47  
ASN N    N N N 48  
ASN CA   C N S 49  
ASN C    C N N 50  
ASN O    O N N 51  
ASN CB   C N N 52  
ASN CG   C N N 53  
ASN OD1  O N N 54  
ASN ND2  N N N 55  
ASN OXT  O N N 56  
ASN H    H N N 57  
ASN H2   H N N 58  
ASN HA   H N N 59  
ASN HB2  H N N 60  
ASN HB3  H N N 61  
ASN HD21 H N N 62  
ASN HD22 H N N 63  
ASN HXT  H N N 64  
ASP N    N N N 65  
ASP CA   C N S 66  
ASP C    C N N 67  
ASP O    O N N 68  
ASP CB   C N N 69  
ASP CG   C N N 70  
ASP OD1  O N N 71  
ASP OD2  O N N 72  
ASP OXT  O N N 73  
ASP H    H N N 74  
ASP H2   H N N 75  
ASP HA   H N N 76  
ASP HB2  H N N 77  
ASP HB3  H N N 78  
ASP HD2  H N N 79  
ASP HXT  H N N 80  
CYS N    N N N 81  
CYS CA   C N R 82  
CYS C    C N N 83  
CYS O    O N N 84  
CYS CB   C N N 85  
CYS SG   S N N 86  
CYS OXT  O N N 87  
CYS H    H N N 88  
CYS H2   H N N 89  
CYS HA   H N N 90  
CYS HB2  H N N 91  
CYS HB3  H N N 92  
CYS HG   H N N 93  
CYS HXT  H N N 94  
GLN N    N N N 95  
GLN CA   C N S 96  
GLN C    C N N 97  
GLN O    O N N 98  
GLN CB   C N N 99  
GLN CG   C N N 100 
GLN CD   C N N 101 
GLN OE1  O N N 102 
GLN NE2  N N N 103 
GLN OXT  O N N 104 
GLN H    H N N 105 
GLN H2   H N N 106 
GLN HA   H N N 107 
GLN HB2  H N N 108 
GLN HB3  H N N 109 
GLN HG2  H N N 110 
GLN HG3  H N N 111 
GLN HE21 H N N 112 
GLN HE22 H N N 113 
GLN HXT  H N N 114 
GLU N    N N N 115 
GLU CA   C N S 116 
GLU C    C N N 117 
GLU O    O N N 118 
GLU CB   C N N 119 
GLU CG   C N N 120 
GLU CD   C N N 121 
GLU OE1  O N N 122 
GLU OE2  O N N 123 
GLU OXT  O N N 124 
GLU H    H N N 125 
GLU H2   H N N 126 
GLU HA   H N N 127 
GLU HB2  H N N 128 
GLU HB3  H N N 129 
GLU HG2  H N N 130 
GLU HG3  H N N 131 
GLU HE2  H N N 132 
GLU HXT  H N N 133 
GLY N    N N N 134 
GLY CA   C N N 135 
GLY C    C N N 136 
GLY O    O N N 137 
GLY OXT  O N N 138 
GLY H    H N N 139 
GLY H2   H N N 140 
GLY HA2  H N N 141 
GLY HA3  H N N 142 
GLY HXT  H N N 143 
HIS N    N N N 144 
HIS CA   C N S 145 
HIS C    C N N 146 
HIS O    O N N 147 
HIS CB   C N N 148 
HIS CG   C Y N 149 
HIS ND1  N Y N 150 
HIS CD2  C Y N 151 
HIS CE1  C Y N 152 
HIS NE2  N Y N 153 
HIS OXT  O N N 154 
HIS H    H N N 155 
HIS H2   H N N 156 
HIS HA   H N N 157 
HIS HB2  H N N 158 
HIS HB3  H N N 159 
HIS HD1  H N N 160 
HIS HD2  H N N 161 
HIS HE1  H N N 162 
HIS HE2  H N N 163 
HIS HXT  H N N 164 
ILE N    N N N 165 
ILE CA   C N S 166 
ILE C    C N N 167 
ILE O    O N N 168 
ILE CB   C N S 169 
ILE CG1  C N N 170 
ILE CG2  C N N 171 
ILE CD1  C N N 172 
ILE OXT  O N N 173 
ILE H    H N N 174 
ILE H2   H N N 175 
ILE HA   H N N 176 
ILE HB   H N N 177 
ILE HG12 H N N 178 
ILE HG13 H N N 179 
ILE HG21 H N N 180 
ILE HG22 H N N 181 
ILE HG23 H N N 182 
ILE HD11 H N N 183 
ILE HD12 H N N 184 
ILE HD13 H N N 185 
ILE HXT  H N N 186 
LEU N    N N N 187 
LEU CA   C N S 188 
LEU C    C N N 189 
LEU O    O N N 190 
LEU CB   C N N 191 
LEU CG   C N N 192 
LEU CD1  C N N 193 
LEU CD2  C N N 194 
LEU OXT  O N N 195 
LEU H    H N N 196 
LEU H2   H N N 197 
LEU HA   H N N 198 
LEU HB2  H N N 199 
LEU HB3  H N N 200 
LEU HG   H N N 201 
LEU HD11 H N N 202 
LEU HD12 H N N 203 
LEU HD13 H N N 204 
LEU HD21 H N N 205 
LEU HD22 H N N 206 
LEU HD23 H N N 207 
LEU HXT  H N N 208 
LYS N    N N N 209 
LYS CA   C N S 210 
LYS C    C N N 211 
LYS O    O N N 212 
LYS CB   C N N 213 
LYS CG   C N N 214 
LYS CD   C N N 215 
LYS CE   C N N 216 
LYS NZ   N N N 217 
LYS OXT  O N N 218 
LYS H    H N N 219 
LYS H2   H N N 220 
LYS HA   H N N 221 
LYS HB2  H N N 222 
LYS HB3  H N N 223 
LYS HG2  H N N 224 
LYS HG3  H N N 225 
LYS HD2  H N N 226 
LYS HD3  H N N 227 
LYS HE2  H N N 228 
LYS HE3  H N N 229 
LYS HZ1  H N N 230 
LYS HZ2  H N N 231 
LYS HZ3  H N N 232 
LYS HXT  H N N 233 
MET N    N N N 234 
MET CA   C N S 235 
MET C    C N N 236 
MET O    O N N 237 
MET CB   C N N 238 
MET CG   C N N 239 
MET SD   S N N 240 
MET CE   C N N 241 
MET OXT  O N N 242 
MET H    H N N 243 
MET H2   H N N 244 
MET HA   H N N 245 
MET HB2  H N N 246 
MET HB3  H N N 247 
MET HG2  H N N 248 
MET HG3  H N N 249 
MET HE1  H N N 250 
MET HE2  H N N 251 
MET HE3  H N N 252 
MET HXT  H N N 253 
PHE N    N N N 254 
PHE CA   C N S 255 
PHE C    C N N 256 
PHE O    O N N 257 
PHE CB   C N N 258 
PHE CG   C Y N 259 
PHE CD1  C Y N 260 
PHE CD2  C Y N 261 
PHE CE1  C Y N 262 
PHE CE2  C Y N 263 
PHE CZ   C Y N 264 
PHE OXT  O N N 265 
PHE H    H N N 266 
PHE H2   H N N 267 
PHE HA   H N N 268 
PHE HB2  H N N 269 
PHE HB3  H N N 270 
PHE HD1  H N N 271 
PHE HD2  H N N 272 
PHE HE1  H N N 273 
PHE HE2  H N N 274 
PHE HZ   H N N 275 
PHE HXT  H N N 276 
PRO N    N N N 277 
PRO CA   C N S 278 
PRO C    C N N 279 
PRO O    O N N 280 
PRO CB   C N N 281 
PRO CG   C N N 282 
PRO CD   C N N 283 
PRO OXT  O N N 284 
PRO H    H N N 285 
PRO HA   H N N 286 
PRO HB2  H N N 287 
PRO HB3  H N N 288 
PRO HG2  H N N 289 
PRO HG3  H N N 290 
PRO HD2  H N N 291 
PRO HD3  H N N 292 
PRO HXT  H N N 293 
SER N    N N N 294 
SER CA   C N S 295 
SER C    C N N 296 
SER O    O N N 297 
SER CB   C N N 298 
SER OG   O N N 299 
SER OXT  O N N 300 
SER H    H N N 301 
SER H2   H N N 302 
SER HA   H N N 303 
SER HB2  H N N 304 
SER HB3  H N N 305 
SER HG   H N N 306 
SER HXT  H N N 307 
THR N    N N N 308 
THR CA   C N S 309 
THR C    C N N 310 
THR O    O N N 311 
THR CB   C N R 312 
THR OG1  O N N 313 
THR CG2  C N N 314 
THR OXT  O N N 315 
THR H    H N N 316 
THR H2   H N N 317 
THR HA   H N N 318 
THR HB   H N N 319 
THR HG1  H N N 320 
THR HG21 H N N 321 
THR HG22 H N N 322 
THR HG23 H N N 323 
THR HXT  H N N 324 
TRP N    N N N 325 
TRP CA   C N S 326 
TRP C    C N N 327 
TRP O    O N N 328 
TRP CB   C N N 329 
TRP CG   C Y N 330 
TRP CD1  C Y N 331 
TRP CD2  C Y N 332 
TRP NE1  N Y N 333 
TRP CE2  C Y N 334 
TRP CE3  C Y N 335 
TRP CZ2  C Y N 336 
TRP CZ3  C Y N 337 
TRP CH2  C Y N 338 
TRP OXT  O N N 339 
TRP H    H N N 340 
TRP H2   H N N 341 
TRP HA   H N N 342 
TRP HB2  H N N 343 
TRP HB3  H N N 344 
TRP HD1  H N N 345 
TRP HE1  H N N 346 
TRP HE3  H N N 347 
TRP HZ2  H N N 348 
TRP HZ3  H N N 349 
TRP HH2  H N N 350 
TRP HXT  H N N 351 
TYR N    N N N 352 
TYR CA   C N S 353 
TYR C    C N N 354 
TYR O    O N N 355 
TYR CB   C N N 356 
TYR CG   C Y N 357 
TYR CD1  C Y N 358 
TYR CD2  C Y N 359 
TYR CE1  C Y N 360 
TYR CE2  C Y N 361 
TYR CZ   C Y N 362 
TYR OH   O N N 363 
TYR OXT  O N N 364 
TYR H    H N N 365 
TYR H2   H N N 366 
TYR HA   H N N 367 
TYR HB2  H N N 368 
TYR HB3  H N N 369 
TYR HD1  H N N 370 
TYR HD2  H N N 371 
TYR HE1  H N N 372 
TYR HE2  H N N 373 
TYR HH   H N N 374 
TYR HXT  H N N 375 
VAL N    N N N 376 
VAL CA   C N S 377 
VAL C    C N N 378 
VAL O    O N N 379 
VAL CB   C N N 380 
VAL CG1  C N N 381 
VAL CG2  C N N 382 
VAL OXT  O N N 383 
VAL H    H N N 384 
VAL H2   H N N 385 
VAL HA   H N N 386 
VAL HB   H N N 387 
VAL HG11 H N N 388 
VAL HG12 H N N 389 
VAL HG13 H N N 390 
VAL HG21 H N N 391 
VAL HG22 H N N 392 
VAL HG23 H N N 393 
VAL HXT  H N N 394 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACT C   O    doub N N 1   
ACT C   OXT  sing N N 2   
ACT C   CH3  sing N N 3   
ACT CH3 H1   sing N N 4   
ACT CH3 H2   sing N N 5   
ACT CH3 H3   sing N N 6   
ALA N   CA   sing N N 7   
ALA N   H    sing N N 8   
ALA N   H2   sing N N 9   
ALA CA  C    sing N N 10  
ALA CA  CB   sing N N 11  
ALA CA  HA   sing N N 12  
ALA C   O    doub N N 13  
ALA C   OXT  sing N N 14  
ALA CB  HB1  sing N N 15  
ALA CB  HB2  sing N N 16  
ALA CB  HB3  sing N N 17  
ALA OXT HXT  sing N N 18  
ARG N   CA   sing N N 19  
ARG N   H    sing N N 20  
ARG N   H2   sing N N 21  
ARG CA  C    sing N N 22  
ARG CA  CB   sing N N 23  
ARG CA  HA   sing N N 24  
ARG C   O    doub N N 25  
ARG C   OXT  sing N N 26  
ARG CB  CG   sing N N 27  
ARG CB  HB2  sing N N 28  
ARG CB  HB3  sing N N 29  
ARG CG  CD   sing N N 30  
ARG CG  HG2  sing N N 31  
ARG CG  HG3  sing N N 32  
ARG CD  NE   sing N N 33  
ARG CD  HD2  sing N N 34  
ARG CD  HD3  sing N N 35  
ARG NE  CZ   sing N N 36  
ARG NE  HE   sing N N 37  
ARG CZ  NH1  sing N N 38  
ARG CZ  NH2  doub N N 39  
ARG NH1 HH11 sing N N 40  
ARG NH1 HH12 sing N N 41  
ARG NH2 HH21 sing N N 42  
ARG NH2 HH22 sing N N 43  
ARG OXT HXT  sing N N 44  
ASN N   CA   sing N N 45  
ASN N   H    sing N N 46  
ASN N   H2   sing N N 47  
ASN CA  C    sing N N 48  
ASN CA  CB   sing N N 49  
ASN CA  HA   sing N N 50  
ASN C   O    doub N N 51  
ASN C   OXT  sing N N 52  
ASN CB  CG   sing N N 53  
ASN CB  HB2  sing N N 54  
ASN CB  HB3  sing N N 55  
ASN CG  OD1  doub N N 56  
ASN CG  ND2  sing N N 57  
ASN ND2 HD21 sing N N 58  
ASN ND2 HD22 sing N N 59  
ASN OXT HXT  sing N N 60  
ASP N   CA   sing N N 61  
ASP N   H    sing N N 62  
ASP N   H2   sing N N 63  
ASP CA  C    sing N N 64  
ASP CA  CB   sing N N 65  
ASP CA  HA   sing N N 66  
ASP C   O    doub N N 67  
ASP C   OXT  sing N N 68  
ASP CB  CG   sing N N 69  
ASP CB  HB2  sing N N 70  
ASP CB  HB3  sing N N 71  
ASP CG  OD1  doub N N 72  
ASP CG  OD2  sing N N 73  
ASP OD2 HD2  sing N N 74  
ASP OXT HXT  sing N N 75  
CYS N   CA   sing N N 76  
CYS N   H    sing N N 77  
CYS N   H2   sing N N 78  
CYS CA  C    sing N N 79  
CYS CA  CB   sing N N 80  
CYS CA  HA   sing N N 81  
CYS C   O    doub N N 82  
CYS C   OXT  sing N N 83  
CYS CB  SG   sing N N 84  
CYS CB  HB2  sing N N 85  
CYS CB  HB3  sing N N 86  
CYS SG  HG   sing N N 87  
CYS OXT HXT  sing N N 88  
GLN N   CA   sing N N 89  
GLN N   H    sing N N 90  
GLN N   H2   sing N N 91  
GLN CA  C    sing N N 92  
GLN CA  CB   sing N N 93  
GLN CA  HA   sing N N 94  
GLN C   O    doub N N 95  
GLN C   OXT  sing N N 96  
GLN CB  CG   sing N N 97  
GLN CB  HB2  sing N N 98  
GLN CB  HB3  sing N N 99  
GLN CG  CD   sing N N 100 
GLN CG  HG2  sing N N 101 
GLN CG  HG3  sing N N 102 
GLN CD  OE1  doub N N 103 
GLN CD  NE2  sing N N 104 
GLN NE2 HE21 sing N N 105 
GLN NE2 HE22 sing N N 106 
GLN OXT HXT  sing N N 107 
GLU N   CA   sing N N 108 
GLU N   H    sing N N 109 
GLU N   H2   sing N N 110 
GLU CA  C    sing N N 111 
GLU CA  CB   sing N N 112 
GLU CA  HA   sing N N 113 
GLU C   O    doub N N 114 
GLU C   OXT  sing N N 115 
GLU CB  CG   sing N N 116 
GLU CB  HB2  sing N N 117 
GLU CB  HB3  sing N N 118 
GLU CG  CD   sing N N 119 
GLU CG  HG2  sing N N 120 
GLU CG  HG3  sing N N 121 
GLU CD  OE1  doub N N 122 
GLU CD  OE2  sing N N 123 
GLU OE2 HE2  sing N N 124 
GLU OXT HXT  sing N N 125 
GLY N   CA   sing N N 126 
GLY N   H    sing N N 127 
GLY N   H2   sing N N 128 
GLY CA  C    sing N N 129 
GLY CA  HA2  sing N N 130 
GLY CA  HA3  sing N N 131 
GLY C   O    doub N N 132 
GLY C   OXT  sing N N 133 
GLY OXT HXT  sing N N 134 
HIS N   CA   sing N N 135 
HIS N   H    sing N N 136 
HIS N   H2   sing N N 137 
HIS CA  C    sing N N 138 
HIS CA  CB   sing N N 139 
HIS CA  HA   sing N N 140 
HIS C   O    doub N N 141 
HIS C   OXT  sing N N 142 
HIS CB  CG   sing N N 143 
HIS CB  HB2  sing N N 144 
HIS CB  HB3  sing N N 145 
HIS CG  ND1  sing Y N 146 
HIS CG  CD2  doub Y N 147 
HIS ND1 CE1  doub Y N 148 
HIS ND1 HD1  sing N N 149 
HIS CD2 NE2  sing Y N 150 
HIS CD2 HD2  sing N N 151 
HIS CE1 NE2  sing Y N 152 
HIS CE1 HE1  sing N N 153 
HIS NE2 HE2  sing N N 154 
HIS OXT HXT  sing N N 155 
ILE N   CA   sing N N 156 
ILE N   H    sing N N 157 
ILE N   H2   sing N N 158 
ILE CA  C    sing N N 159 
ILE CA  CB   sing N N 160 
ILE CA  HA   sing N N 161 
ILE C   O    doub N N 162 
ILE C   OXT  sing N N 163 
ILE CB  CG1  sing N N 164 
ILE CB  CG2  sing N N 165 
ILE CB  HB   sing N N 166 
ILE CG1 CD1  sing N N 167 
ILE CG1 HG12 sing N N 168 
ILE CG1 HG13 sing N N 169 
ILE CG2 HG21 sing N N 170 
ILE CG2 HG22 sing N N 171 
ILE CG2 HG23 sing N N 172 
ILE CD1 HD11 sing N N 173 
ILE CD1 HD12 sing N N 174 
ILE CD1 HD13 sing N N 175 
ILE OXT HXT  sing N N 176 
LEU N   CA   sing N N 177 
LEU N   H    sing N N 178 
LEU N   H2   sing N N 179 
LEU CA  C    sing N N 180 
LEU CA  CB   sing N N 181 
LEU CA  HA   sing N N 182 
LEU C   O    doub N N 183 
LEU C   OXT  sing N N 184 
LEU CB  CG   sing N N 185 
LEU CB  HB2  sing N N 186 
LEU CB  HB3  sing N N 187 
LEU CG  CD1  sing N N 188 
LEU CG  CD2  sing N N 189 
LEU CG  HG   sing N N 190 
LEU CD1 HD11 sing N N 191 
LEU CD1 HD12 sing N N 192 
LEU CD1 HD13 sing N N 193 
LEU CD2 HD21 sing N N 194 
LEU CD2 HD22 sing N N 195 
LEU CD2 HD23 sing N N 196 
LEU OXT HXT  sing N N 197 
LYS N   CA   sing N N 198 
LYS N   H    sing N N 199 
LYS N   H2   sing N N 200 
LYS CA  C    sing N N 201 
LYS CA  CB   sing N N 202 
LYS CA  HA   sing N N 203 
LYS C   O    doub N N 204 
LYS C   OXT  sing N N 205 
LYS CB  CG   sing N N 206 
LYS CB  HB2  sing N N 207 
LYS CB  HB3  sing N N 208 
LYS CG  CD   sing N N 209 
LYS CG  HG2  sing N N 210 
LYS CG  HG3  sing N N 211 
LYS CD  CE   sing N N 212 
LYS CD  HD2  sing N N 213 
LYS CD  HD3  sing N N 214 
LYS CE  NZ   sing N N 215 
LYS CE  HE2  sing N N 216 
LYS CE  HE3  sing N N 217 
LYS NZ  HZ1  sing N N 218 
LYS NZ  HZ2  sing N N 219 
LYS NZ  HZ3  sing N N 220 
LYS OXT HXT  sing N N 221 
MET N   CA   sing N N 222 
MET N   H    sing N N 223 
MET N   H2   sing N N 224 
MET CA  C    sing N N 225 
MET CA  CB   sing N N 226 
MET CA  HA   sing N N 227 
MET C   O    doub N N 228 
MET C   OXT  sing N N 229 
MET CB  CG   sing N N 230 
MET CB  HB2  sing N N 231 
MET CB  HB3  sing N N 232 
MET CG  SD   sing N N 233 
MET CG  HG2  sing N N 234 
MET CG  HG3  sing N N 235 
MET SD  CE   sing N N 236 
MET CE  HE1  sing N N 237 
MET CE  HE2  sing N N 238 
MET CE  HE3  sing N N 239 
MET OXT HXT  sing N N 240 
PHE N   CA   sing N N 241 
PHE N   H    sing N N 242 
PHE N   H2   sing N N 243 
PHE CA  C    sing N N 244 
PHE CA  CB   sing N N 245 
PHE CA  HA   sing N N 246 
PHE C   O    doub N N 247 
PHE C   OXT  sing N N 248 
PHE CB  CG   sing N N 249 
PHE CB  HB2  sing N N 250 
PHE CB  HB3  sing N N 251 
PHE CG  CD1  doub Y N 252 
PHE CG  CD2  sing Y N 253 
PHE CD1 CE1  sing Y N 254 
PHE CD1 HD1  sing N N 255 
PHE CD2 CE2  doub Y N 256 
PHE CD2 HD2  sing N N 257 
PHE CE1 CZ   doub Y N 258 
PHE CE1 HE1  sing N N 259 
PHE CE2 CZ   sing Y N 260 
PHE CE2 HE2  sing N N 261 
PHE CZ  HZ   sing N N 262 
PHE OXT HXT  sing N N 263 
PRO N   CA   sing N N 264 
PRO N   CD   sing N N 265 
PRO N   H    sing N N 266 
PRO CA  C    sing N N 267 
PRO CA  CB   sing N N 268 
PRO CA  HA   sing N N 269 
PRO C   O    doub N N 270 
PRO C   OXT  sing N N 271 
PRO CB  CG   sing N N 272 
PRO CB  HB2  sing N N 273 
PRO CB  HB3  sing N N 274 
PRO CG  CD   sing N N 275 
PRO CG  HG2  sing N N 276 
PRO CG  HG3  sing N N 277 
PRO CD  HD2  sing N N 278 
PRO CD  HD3  sing N N 279 
PRO OXT HXT  sing N N 280 
SER N   CA   sing N N 281 
SER N   H    sing N N 282 
SER N   H2   sing N N 283 
SER CA  C    sing N N 284 
SER CA  CB   sing N N 285 
SER CA  HA   sing N N 286 
SER C   O    doub N N 287 
SER C   OXT  sing N N 288 
SER CB  OG   sing N N 289 
SER CB  HB2  sing N N 290 
SER CB  HB3  sing N N 291 
SER OG  HG   sing N N 292 
SER OXT HXT  sing N N 293 
THR N   CA   sing N N 294 
THR N   H    sing N N 295 
THR N   H2   sing N N 296 
THR CA  C    sing N N 297 
THR CA  CB   sing N N 298 
THR CA  HA   sing N N 299 
THR C   O    doub N N 300 
THR C   OXT  sing N N 301 
THR CB  OG1  sing N N 302 
THR CB  CG2  sing N N 303 
THR CB  HB   sing N N 304 
THR OG1 HG1  sing N N 305 
THR CG2 HG21 sing N N 306 
THR CG2 HG22 sing N N 307 
THR CG2 HG23 sing N N 308 
THR OXT HXT  sing N N 309 
TRP N   CA   sing N N 310 
TRP N   H    sing N N 311 
TRP N   H2   sing N N 312 
TRP CA  C    sing N N 313 
TRP CA  CB   sing N N 314 
TRP CA  HA   sing N N 315 
TRP C   O    doub N N 316 
TRP C   OXT  sing N N 317 
TRP CB  CG   sing N N 318 
TRP CB  HB2  sing N N 319 
TRP CB  HB3  sing N N 320 
TRP CG  CD1  doub Y N 321 
TRP CG  CD2  sing Y N 322 
TRP CD1 NE1  sing Y N 323 
TRP CD1 HD1  sing N N 324 
TRP CD2 CE2  doub Y N 325 
TRP CD2 CE3  sing Y N 326 
TRP NE1 CE2  sing Y N 327 
TRP NE1 HE1  sing N N 328 
TRP CE2 CZ2  sing Y N 329 
TRP CE3 CZ3  doub Y N 330 
TRP CE3 HE3  sing N N 331 
TRP CZ2 CH2  doub Y N 332 
TRP CZ2 HZ2  sing N N 333 
TRP CZ3 CH2  sing Y N 334 
TRP CZ3 HZ3  sing N N 335 
TRP CH2 HH2  sing N N 336 
TRP OXT HXT  sing N N 337 
TYR N   CA   sing N N 338 
TYR N   H    sing N N 339 
TYR N   H2   sing N N 340 
TYR CA  C    sing N N 341 
TYR CA  CB   sing N N 342 
TYR CA  HA   sing N N 343 
TYR C   O    doub N N 344 
TYR C   OXT  sing N N 345 
TYR CB  CG   sing N N 346 
TYR CB  HB2  sing N N 347 
TYR CB  HB3  sing N N 348 
TYR CG  CD1  doub Y N 349 
TYR CG  CD2  sing Y N 350 
TYR CD1 CE1  sing Y N 351 
TYR CD1 HD1  sing N N 352 
TYR CD2 CE2  doub Y N 353 
TYR CD2 HD2  sing N N 354 
TYR CE1 CZ   doub Y N 355 
TYR CE1 HE1  sing N N 356 
TYR CE2 CZ   sing Y N 357 
TYR CE2 HE2  sing N N 358 
TYR CZ  OH   sing N N 359 
TYR OH  HH   sing N N 360 
TYR OXT HXT  sing N N 361 
VAL N   CA   sing N N 362 
VAL N   H    sing N N 363 
VAL N   H2   sing N N 364 
VAL CA  C    sing N N 365 
VAL CA  CB   sing N N 366 
VAL CA  HA   sing N N 367 
VAL C   O    doub N N 368 
VAL C   OXT  sing N N 369 
VAL CB  CG1  sing N N 370 
VAL CB  CG2  sing N N 371 
VAL CB  HB   sing N N 372 
VAL CG1 HG11 sing N N 373 
VAL CG1 HG12 sing N N 374 
VAL CG1 HG13 sing N N 375 
VAL CG2 HG21 sing N N 376 
VAL CG2 HG22 sing N N 377 
VAL CG2 HG23 sing N N 378 
VAL OXT HXT  sing N N 379 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3V6O 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    7EQ3 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   0.009363 
_atom_sites.fract_transf_matrix[1][2]   0.005406 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010811 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019992 
_atom_sites.fract_transf_vector[1]      0.000000 
_atom_sites.fract_transf_vector[2]      0.000000 
_atom_sites.fract_transf_vector[3]      0.000000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLU A 1 2   ? -55.826 21.680  -11.206 1.00 65.86  ? 1   GLU A N   1 
ATOM   2    C CA  . GLU A 1 2   ? -55.887 20.443  -10.449 1.00 65.86  ? 1   GLU A CA  1 
ATOM   3    C C   . GLU A 1 2   ? -54.509 20.115  -9.910  1.00 65.86  ? 1   GLU A C   1 
ATOM   4    O O   . GLU A 1 2   ? -53.537 20.089  -10.658 1.00 65.86  ? 1   GLU A O   1 
ATOM   5    C CB  . GLU A 1 2   ? -56.397 19.307  -11.320 1.00 65.86  ? 1   GLU A CB  1 
ATOM   6    C CG  . GLU A 1 2   ? -56.636 18.044  -10.541 1.00 65.86  ? 1   GLU A CG  1 
ATOM   7    C CD  . GLU A 1 2   ? -56.960 16.868  -11.431 1.00 65.86  ? 1   GLU A CD  1 
ATOM   8    O OE1 . GLU A 1 2   ? -56.520 16.871  -12.598 1.00 65.86  ? 1   GLU A OE1 1 
ATOM   9    O OE2 . GLU A 1 2   ? -57.657 15.939  -10.971 1.00 65.86  ? 1   GLU A OE2 1 
ATOM   10   N N   . VAL A 1 3   ? -54.420 19.897  -8.607  1.00 60.94  ? 2   VAL A N   1 
ATOM   11   C CA  . VAL A 1 3   ? -53.155 19.595  -7.955  1.00 53.63  ? 2   VAL A CA  1 
ATOM   12   C C   . VAL A 1 3   ? -52.934 18.097  -8.031  1.00 59.41  ? 2   VAL A C   1 
ATOM   13   O O   . VAL A 1 3   ? -53.818 17.320  -7.664  1.00 57.21  ? 2   VAL A O   1 
ATOM   14   C CB  . VAL A 1 3   ? -53.162 20.060  -6.492  1.00 49.87  ? 2   VAL A CB  1 
ATOM   15   C CG1 . VAL A 1 3   ? -51.795 19.875  -5.886  1.00 48.24  ? 2   VAL A CG1 1 
ATOM   16   C CG2 . VAL A 1 3   ? -53.642 21.504  -6.369  1.00 57.08  ? 2   VAL A CG2 1 
ATOM   17   N N   . LYS A 1 4   ? -51.760 17.684  -8.495  1.00 46.45  ? 3   LYS A N   1 
ATOM   18   C CA  . LYS A 1 4   ? -51.478 16.273  -8.703  1.00 46.73  ? 3   LYS A CA  1 
ATOM   19   C C   . LYS A 1 4   ? -50.156 15.897  -8.066  1.00 47.93  ? 3   LYS A C   1 
ATOM   20   O O   . LYS A 1 4   ? -49.172 16.624  -8.187  1.00 41.69  ? 3   LYS A O   1 
ATOM   21   C CB  . LYS A 1 4   ? -51.418 15.924  -10.181 1.00 52.12  ? 3   LYS A CB  1 
ATOM   22   C CG  . LYS A 1 4   ? -52.653 16.311  -10.983 1.00 61.23  ? 3   LYS A CG  1 
ATOM   23   C CD  . LYS A 1 4   ? -53.898 15.525  -10.581 1.00 77.75  ? 3   LYS A CD  1 
ATOM   24   C CE  . LYS A 1 4   ? -54.290 14.494  -11.627 1.00 90.61  ? 3   LYS A CE  1 
ATOM   25   N NZ  . LYS A 1 4   ? -55.581 13.867  -11.239 1.00 67.79  ? 3   LYS A NZ  1 
ATOM   26   N N   . LEU A 1 5   ? -50.129 14.740  -7.421  1.00 43.53  ? 4   LEU A N   1 
ATOM   27   C CA  . LEU A 1 5   ? -48.882 14.156  -6.954  1.00 38.54  ? 4   LEU A CA  1 
ATOM   28   C C   . LEU A 1 5   ? -48.970 12.654  -7.144  1.00 41.17  ? 4   LEU A C   1 
ATOM   29   O O   . LEU A 1 5   ? -49.938 12.033  -6.701  1.00 43.23  ? 4   LEU A O   1 
ATOM   30   C CB  . LEU A 1 5   ? -48.615 14.488  -5.477  1.00 37.68  ? 4   LEU A CB  1 
ATOM   31   C CG  . LEU A 1 5   ? -48.558 15.914  -4.963  1.00 41.86  ? 4   LEU A CG  1 
ATOM   32   C CD1 . LEU A 1 5   ? -49.836 16.255  -4.225  1.00 40.52  ? 4   LEU A CD1 1 
ATOM   33   C CD2 . LEU A 1 5   ? -47.361 16.112  -4.043  1.00 43.92  ? 4   LEU A CD2 1 
ATOM   34   N N   . LEU A 1 6   ? -47.975 12.071  -7.804  1.00 41.41  ? 5   LEU A N   1 
ATOM   35   C CA  . LEU A 1 6   ? -47.955 10.634  -8.026  1.00 40.76  ? 5   LEU A CA  1 
ATOM   36   C C   . LEU A 1 6   ? -46.609 10.079  -7.596  1.00 38.62  ? 5   LEU A C   1 
ATOM   37   O O   . LEU A 1 6   ? -45.562 10.557  -8.045  1.00 41.42  ? 5   LEU A O   1 
ATOM   38   C CB  . LEU A 1 6   ? -48.229 10.280  -9.493  1.00 48.99  ? 5   LEU A CB  1 
ATOM   39   C CG  . LEU A 1 6   ? -48.320 8.771   -9.742  1.00 73.07  ? 5   LEU A CG  1 
ATOM   40   C CD1 . LEU A 1 6   ? -49.303 8.126   -8.772  1.00 69.18  ? 5   LEU A CD1 1 
ATOM   41   C CD2 . LEU A 1 6   ? -48.710 8.470   -11.180 1.00 76.76  ? 5   LEU A CD2 1 
ATOM   42   N N   . GLU A 1 7   ? -46.644 9.075   -6.726  1.00 39.94  ? 6   GLU A N   1 
ATOM   43   C CA  . GLU A 1 7   ? -45.446 8.405   -6.244  1.00 41.48  ? 6   GLU A CA  1 
ATOM   44   C C   . GLU A 1 7   ? -45.025 7.309   -7.213  1.00 47.99  ? 6   GLU A C   1 
ATOM   45   O O   . GLU A 1 7   ? -45.858 6.660   -7.851  1.00 42.11  ? 6   GLU A O   1 
ATOM   46   C CB  . GLU A 1 7   ? -45.678 7.802   -4.855  1.00 39.70  ? 6   GLU A CB  1 
ATOM   47   C CG  . GLU A 1 7   ? -46.071 8.802   -3.777  1.00 40.03  ? 6   GLU A CG  1 
ATOM   48   C CD  . GLU A 1 7   ? -47.554 9.113   -3.767  1.00 39.50  ? 6   GLU A CD  1 
ATOM   49   O OE1 . GLU A 1 7   ? -48.252 8.750   -4.734  1.00 43.06  ? 6   GLU A OE1 1 
ATOM   50   O OE2 . GLU A 1 7   ? -48.026 9.717   -2.782  1.00 39.71  ? 6   GLU A OE2 1 
ATOM   51   N N   . SER A 1 8   ? -43.712 7.115   -7.319  1.00 44.84  ? 7   SER A N   1 
ATOM   52   C CA  . SER A 1 8   ? -43.116 6.067   -8.141  1.00 48.20  ? 7   SER A CA  1 
ATOM   53   C C   . SER A 1 8   ? -42.089 5.351   -7.278  1.00 49.47  ? 7   SER A C   1 
ATOM   54   O O   . SER A 1 8   ? -41.056 5.932   -6.934  1.00 44.54  ? 7   SER A O   1 
ATOM   55   C CB  . SER A 1 8   ? -42.466 6.649   -9.397  1.00 48.51  ? 7   SER A CB  1 
ATOM   56   O OG  . SER A 1 8   ? -43.366 7.489   -10.097 1.00 64.37  ? 7   SER A OG  1 
ATOM   57   N N   . GLY A 1 9   ? -42.372 4.099   -6.926  1.00 53.39  ? 8   GLY A N   1 
ATOM   58   C CA  . GLY A 1 9   ? -41.513 3.348   -6.042  1.00 59.83  ? 8   GLY A CA  1 
ATOM   59   C C   . GLY A 1 9   ? -41.360 1.899   -6.454  1.00 56.48  ? 8   GLY A C   1 
ATOM   60   O O   . GLY A 1 9   ? -42.161 1.357   -7.222  1.00 55.51  ? 8   GLY A O   1 
ATOM   61   N N   . PRO A 1 10  ? -40.331 1.232   -5.921  1.00 53.31  ? 9   PRO A N   1 
ATOM   62   C CA  . PRO A 1 10  ? -40.023 -0.132  -6.389  1.00 59.83  ? 9   PRO A CA  1 
ATOM   63   C C   . PRO A 1 10  ? -41.107 -1.150  -6.081  1.00 59.09  ? 9   PRO A C   1 
ATOM   64   O O   . PRO A 1 10  ? -41.392 -2.014  -6.920  1.00 61.54  ? 9   PRO A O   1 
ATOM   65   C CB  . PRO A 1 10  ? -38.713 -0.457  -5.656  1.00 57.38  ? 9   PRO A CB  1 
ATOM   66   C CG  . PRO A 1 10  ? -38.744 0.403   -4.438  1.00 57.16  ? 9   PRO A CG  1 
ATOM   67   C CD  . PRO A 1 10  ? -39.417 1.676   -4.857  1.00 55.97  ? 9   PRO A CD  1 
ATOM   68   N N   . GLY A 1 11  ? -41.717 -1.088  -4.903  1.00 58.93  ? 10  GLY A N   1 
ATOM   69   C CA  . GLY A 1 11  ? -42.733 -2.059  -4.557  1.00 55.52  ? 10  GLY A CA  1 
ATOM   70   C C   . GLY A 1 11  ? -42.197 -3.226  -3.753  1.00 53.19  ? 10  GLY A C   1 
ATOM   71   O O   . GLY A 1 11  ? -42.808 -3.630  -2.759  1.00 58.19  ? 10  GLY A O   1 
ATOM   72   N N   . LEU A 1 12  ? -41.061 -3.781  -4.171  1.00 57.37  ? 11  LEU A N   1 
ATOM   73   C CA  . LEU A 1 12  ? -40.404 -4.858  -3.442  1.00 57.73  ? 11  LEU A CA  1 
ATOM   74   C C   . LEU A 1 12  ? -38.950 -4.488  -3.206  1.00 57.95  ? 11  LEU A C   1 
ATOM   75   O O   . LEU A 1 12  ? -38.232 -4.148  -4.152  1.00 62.99  ? 11  LEU A O   1 
ATOM   76   C CB  . LEU A 1 12  ? -40.488 -6.187  -4.198  1.00 59.24  ? 11  LEU A CB  1 
ATOM   77   C CG  . LEU A 1 12  ? -40.178 -7.413  -3.336  1.00 69.28  ? 11  LEU A CG  1 
ATOM   78   C CD1 . LEU A 1 12  ? -41.368 -7.744  -2.448  1.00 55.34  ? 11  LEU A CD1 1 
ATOM   79   C CD2 . LEU A 1 12  ? -39.780 -8.607  -4.189  1.00 62.82  ? 11  LEU A CD2 1 
ATOM   80   N N   . VAL A 1 13  ? -38.521 -4.542  -1.947  1.00 63.91  ? 12  VAL A N   1 
ATOM   81   C CA  . VAL A 1 13  ? -37.140 -4.266  -1.573  1.00 64.72  ? 12  VAL A CA  1 
ATOM   82   C C   . VAL A 1 13  ? -36.683 -5.339  -0.595  1.00 67.79  ? 12  VAL A C   1 
ATOM   83   O O   . VAL A 1 13  ? -37.425 -5.719  0.317   1.00 66.70  ? 12  VAL A O   1 
ATOM   84   C CB  . VAL A 1 13  ? -36.973 -2.864  -0.946  1.00 67.11  ? 12  VAL A CB  1 
ATOM   85   C CG1 . VAL A 1 13  ? -35.505 -2.485  -0.894  1.00 62.17  ? 12  VAL A CG1 1 
ATOM   86   C CG2 . VAL A 1 13  ? -37.768 -1.817  -1.713  1.00 62.18  ? 12  VAL A CG2 1 
ATOM   87   N N   . ALA A 1 14  ? -35.461 -5.828  -0.785  1.00 72.60  ? 13  ALA A N   1 
ATOM   88   C CA  . ALA A 1 14  ? -34.915 -6.805  0.140   1.00 73.42  ? 13  ALA A CA  1 
ATOM   89   C C   . ALA A 1 14  ? -34.348 -6.104  1.374   1.00 72.32  ? 13  ALA A C   1 
ATOM   90   O O   . ALA A 1 14  ? -33.841 -4.983  1.277   1.00 70.73  ? 13  ALA A O   1 
ATOM   91   C CB  . ALA A 1 14  ? -33.824 -7.629  -0.534  1.00 75.20  ? 13  ALA A CB  1 
ATOM   92   N N   . PRO A 1 15  ? -34.445 -6.734  2.545   1.00 64.01  ? 14  PRO A N   1 
ATOM   93   C CA  . PRO A 1 15  ? -33.876 -6.132  3.757   1.00 67.59  ? 14  PRO A CA  1 
ATOM   94   C C   . PRO A 1 15  ? -32.411 -5.768  3.568   1.00 69.82  ? 14  PRO A C   1 
ATOM   95   O O   . PRO A 1 15  ? -31.664 -6.461  2.873   1.00 63.34  ? 14  PRO A O   1 
ATOM   96   C CB  . PRO A 1 15  ? -34.058 -7.229  4.810   1.00 70.07  ? 14  PRO A CB  1 
ATOM   97   C CG  . PRO A 1 15  ? -35.269 -7.970  4.354   1.00 72.68  ? 14  PRO A CG  1 
ATOM   98   C CD  . PRO A 1 15  ? -35.222 -7.949  2.846   1.00 67.42  ? 14  PRO A CD  1 
ATOM   99   N N   . SER A 1 16  ? -32.017 -4.653  4.186   1.00 66.57  ? 15  SER A N   1 
ATOM   100  C CA  . SER A 1 16  ? -30.694 -4.018  4.169   1.00 63.37  ? 15  SER A CA  1 
ATOM   101  C C   . SER A 1 16  ? -30.470 -3.183  2.911   1.00 67.91  ? 15  SER A C   1 
ATOM   102  O O   . SER A 1 16  ? -29.428 -2.526  2.812   1.00 71.38  ? 15  SER A O   1 
ATOM   103  C CB  . SER A 1 16  ? -29.534 -5.018  4.317   1.00 76.11  ? 15  SER A CB  1 
ATOM   104  O OG  . SER A 1 16  ? -29.645 -5.744  5.528   1.00 76.06  ? 15  SER A OG  1 
ATOM   105  N N   . GLU A 1 17  ? -31.399 -3.172  1.961   1.00 64.70  ? 16  GLU A N   1 
ATOM   106  C CA  . GLU A 1 17  ? -31.278 -2.333  0.779   1.00 65.98  ? 16  GLU A CA  1 
ATOM   107  C C   . GLU A 1 17  ? -31.839 -0.939  1.048   1.00 65.89  ? 16  GLU A C   1 
ATOM   108  O O   . GLU A 1 17  ? -32.391 -0.652  2.112   1.00 63.70  ? 16  GLU A O   1 
ATOM   109  C CB  . GLU A 1 17  ? -31.992 -2.973  -0.411  1.00 67.32  ? 16  GLU A CB  1 
ATOM   110  C CG  . GLU A 1 17  ? -31.149 -3.970  -1.178  1.00 82.73  ? 16  GLU A CG  1 
ATOM   111  C CD  . GLU A 1 17  ? -31.987 -4.903  -2.028  1.00 99.56  ? 16  GLU A CD  1 
ATOM   112  O OE1 . GLU A 1 17  ? -31.549 -6.052  -2.249  1.00 92.04  ? 16  GLU A OE1 1 
ATOM   113  O OE2 . GLU A 1 17  ? -33.084 -4.493  -2.466  1.00 102.12 ? 16  GLU A OE2 1 
ATOM   114  N N   . SER A 1 18  ? -31.690 -0.063  0.058   1.00 60.29  ? 17  SER A N   1 
ATOM   115  C CA  . SER A 1 18  ? -32.180 1.300   0.159   1.00 59.47  ? 17  SER A CA  1 
ATOM   116  C C   . SER A 1 18  ? -33.577 1.406   -0.450  1.00 67.36  ? 17  SER A C   1 
ATOM   117  O O   . SER A 1 18  ? -34.175 0.418   -0.881  1.00 59.93  ? 17  SER A O   1 
ATOM   118  C CB  . SER A 1 18  ? -31.207 2.268   -0.517  1.00 67.50  ? 17  SER A CB  1 
ATOM   119  O OG  . SER A 1 18  ? -31.057 1.968   -1.893  1.00 62.43  ? 17  SER A OG  1 
ATOM   120  N N   . LEU A 1 19  ? -34.107 2.627   -0.482  1.00 60.63  ? 18  LEU A N   1 
ATOM   121  C CA  . LEU A 1 19  ? -35.431 2.888   -1.030  1.00 54.17  ? 18  LEU A CA  1 
ATOM   122  C C   . LEU A 1 19  ? -35.426 4.269   -1.662  1.00 55.89  ? 18  LEU A C   1 
ATOM   123  O O   . LEU A 1 19  ? -35.086 5.251   -0.997  1.00 56.55  ? 18  LEU A O   1 
ATOM   124  C CB  . LEU A 1 19  ? -36.510 2.803   0.055   1.00 54.63  ? 18  LEU A CB  1 
ATOM   125  C CG  . LEU A 1 19  ? -37.933 3.234   -0.307  1.00 55.34  ? 18  LEU A CG  1 
ATOM   126  C CD1 . LEU A 1 19  ? -38.509 2.341   -1.389  1.00 55.23  ? 18  LEU A CD1 1 
ATOM   127  C CD2 . LEU A 1 19  ? -38.830 3.232   0.923   1.00 52.57  ? 18  LEU A CD2 1 
ATOM   128  N N   . SER A 1 20  ? -35.792 4.338   -2.940  1.00 51.98  ? 19  SER A N   1 
ATOM   129  C CA  . SER A 1 20  ? -35.830 5.596   -3.679  1.00 51.67  ? 19  SER A CA  1 
ATOM   130  C C   . SER A 1 20  ? -37.210 5.742   -4.306  1.00 52.21  ? 19  SER A C   1 
ATOM   131  O O   . SER A 1 20  ? -37.573 4.975   -5.203  1.00 51.58  ? 19  SER A O   1 
ATOM   132  C CB  . SER A 1 20  ? -34.733 5.652   -4.745  1.00 59.85  ? 19  SER A CB  1 
ATOM   133  O OG  . SER A 1 20  ? -33.447 5.718   -4.148  1.00 56.59  ? 19  SER A OG  1 
ATOM   134  N N   . ILE A 1 21  ? -37.969 6.728   -3.831  1.00 44.80  ? 20  ILE A N   1 
ATOM   135  C CA  . ILE A 1 21  ? -39.313 7.013   -4.313  1.00 46.69  ? 20  ILE A CA  1 
ATOM   136  C C   . ILE A 1 21  ? -39.314 8.393   -4.957  1.00 48.96  ? 20  ILE A C   1 
ATOM   137  O O   . ILE A 1 21  ? -38.642 9.315   -4.479  1.00 49.68  ? 20  ILE A O   1 
ATOM   138  C CB  . ILE A 1 21  ? -40.354 6.937   -3.175  1.00 47.15  ? 20  ILE A CB  1 
ATOM   139  C CG1 . ILE A 1 21  ? -40.064 5.747   -2.260  1.00 48.63  ? 20  ILE A CG1 1 
ATOM   140  C CG2 . ILE A 1 21  ? -41.766 6.830   -3.748  1.00 43.45  ? 20  ILE A CG2 1 
ATOM   141  C CD1 . ILE A 1 21  ? -41.084 5.579   -1.150  1.00 46.00  ? 20  ILE A CD1 1 
ATOM   142  N N   . THR A 1 22  ? -40.076 8.533   -6.039  1.00 44.67  ? 21  THR A N   1 
ATOM   143  C CA  . THR A 1 22  ? -40.142 9.770   -6.807  1.00 43.48  ? 21  THR A CA  1 
ATOM   144  C C   . THR A 1 22  ? -41.565 10.311  -6.768  1.00 49.88  ? 21  THR A C   1 
ATOM   145  O O   . THR A 1 22  ? -42.509 9.612   -7.151  1.00 47.83  ? 21  THR A O   1 
ATOM   146  C CB  . THR A 1 22  ? -39.686 9.547   -8.255  1.00 47.70  ? 21  THR A CB  1 
ATOM   147  O OG1 . THR A 1 22  ? -38.260 9.411   -8.291  1.00 45.49  ? 21  THR A OG1 1 
ATOM   148  C CG2 . THR A 1 22  ? -40.109 10.707  -9.149  1.00 44.33  ? 21  THR A CG2 1 
ATOM   149  N N   . CYS A 1 23  ? -41.712 11.551  -6.303  1.00 45.38  ? 22  CYS A N   1 
ATOM   150  C CA  . CYS A 1 23  ? -42.993 12.247  -6.298  1.00 41.29  ? 22  CYS A CA  1 
ATOM   151  C C   . CYS A 1 23  ? -43.028 13.184  -7.500  1.00 49.01  ? 22  CYS A C   1 
ATOM   152  O O   . CYS A 1 23  ? -42.366 14.225  -7.500  1.00 49.09  ? 22  CYS A O   1 
ATOM   153  C CB  . CYS A 1 23  ? -43.184 13.014  -4.991  1.00 47.55  ? 22  CYS A CB  1 
ATOM   154  S SG  . CYS A 1 23  ? -44.824 13.744  -4.733  1.00 47.19  ? 22  CYS A SG  1 
ATOM   155  N N   . THR A 1 24  ? -43.788 12.808  -8.524  1.00 48.11  ? 23  THR A N   1 
ATOM   156  C CA  . THR A 1 24  ? -43.967 13.644  -9.704  1.00 49.79  ? 23  THR A CA  1 
ATOM   157  C C   . THR A 1 24  ? -45.183 14.534  -9.482  1.00 51.57  ? 23  THR A C   1 
ATOM   158  O O   . THR A 1 24  ? -46.302 14.034  -9.325  1.00 46.50  ? 23  THR A O   1 
ATOM   159  C CB  . THR A 1 24  ? -44.136 12.792  -10.960 1.00 50.21  ? 23  THR A CB  1 
ATOM   160  O OG1 . THR A 1 24  ? -43.105 11.794  -11.002 1.00 48.45  ? 23  THR A OG1 1 
ATOM   161  C CG2 . THR A 1 24  ? -44.044 13.657  -12.209 1.00 48.30  ? 23  THR A CG2 1 
ATOM   162  N N   . ILE A 1 25  ? -44.961 15.843  -9.460  1.00 48.78  ? 24  ILE A N   1 
ATOM   163  C CA  . ILE A 1 25  ? -45.982 16.794  -9.048  1.00 48.93  ? 24  ILE A CA  1 
ATOM   164  C C   . ILE A 1 25  ? -46.395 17.642  -10.242 1.00 52.04  ? 24  ILE A C   1 
ATOM   165  O O   . ILE A 1 25  ? -45.651 17.808  -11.213 1.00 47.05  ? 24  ILE A O   1 
ATOM   166  C CB  . ILE A 1 25  ? -45.493 17.679  -7.884  1.00 46.15  ? 24  ILE A CB  1 
ATOM   167  C CG1 . ILE A 1 25  ? -44.402 18.645  -8.355  1.00 44.80  ? 24  ILE A CG1 1 
ATOM   168  C CG2 . ILE A 1 25  ? -44.974 16.812  -6.747  1.00 44.71  ? 24  ILE A CG2 1 
ATOM   169  C CD1 . ILE A 1 25  ? -44.859 20.087  -8.466  1.00 52.31  ? 24  ILE A CD1 1 
ATOM   170  N N   . SER A 1 26  ? -47.611 18.179  -10.162 1.00 54.82  ? 25  SER A N   1 
ATOM   171  C CA  . SER A 1 26  ? -48.121 19.101  -11.166 1.00 54.79  ? 25  SER A CA  1 
ATOM   172  C C   . SER A 1 26  ? -49.220 19.937  -10.528 1.00 57.05  ? 25  SER A C   1 
ATOM   173  O O   . SER A 1 26  ? -49.811 19.549  -9.516  1.00 49.12  ? 25  SER A O   1 
ATOM   174  C CB  . SER A 1 26  ? -48.651 18.367  -12.404 1.00 59.28  ? 25  SER A CB  1 
ATOM   175  O OG  . SER A 1 26  ? -50.049 18.144  -12.307 1.00 61.49  ? 25  SER A OG  1 
ATOM   176  N N   . GLY A 1 27  ? -49.487 21.091  -11.135 1.00 51.59  ? 26  GLY A N   1 
ATOM   177  C CA  . GLY A 1 27  ? -50.515 21.984  -10.648 1.00 56.45  ? 26  GLY A CA  1 
ATOM   178  C C   . GLY A 1 27  ? -50.068 22.970  -9.590  1.00 54.72  ? 26  GLY A C   1 
ATOM   179  O O   . GLY A 1 27  ? -50.871 23.818  -9.181  1.00 55.04  ? 26  GLY A O   1 
ATOM   180  N N   . PHE A 1 28  ? -48.824 22.885  -9.128  1.00 47.61  ? 27  PHE A N   1 
ATOM   181  C CA  . PHE A 1 28  ? -48.285 23.847  -8.178  1.00 47.68  ? 27  PHE A CA  1 
ATOM   182  C C   . PHE A 1 28  ? -46.784 23.960  -8.412  1.00 50.94  ? 27  PHE A C   1 
ATOM   183  O O   . PHE A 1 28  ? -46.210 23.249  -9.241  1.00 47.86  ? 27  PHE A O   1 
ATOM   184  C CB  . PHE A 1 28  ? -48.619 23.454  -6.734  1.00 45.50  ? 27  PHE A CB  1 
ATOM   185  C CG  . PHE A 1 28  ? -47.939 22.198  -6.267  1.00 47.63  ? 27  PHE A CG  1 
ATOM   186  C CD1 . PHE A 1 28  ? -46.763 22.262  -5.538  1.00 48.08  ? 27  PHE A CD1 1 
ATOM   187  C CD2 . PHE A 1 28  ? -48.480 20.954  -6.549  1.00 46.30  ? 27  PHE A CD2 1 
ATOM   188  C CE1 . PHE A 1 28  ? -46.136 21.112  -5.104  1.00 45.76  ? 27  PHE A CE1 1 
ATOM   189  C CE2 . PHE A 1 28  ? -47.857 19.801  -6.117  1.00 46.59  ? 27  PHE A CE2 1 
ATOM   190  C CZ  . PHE A 1 28  ? -46.683 19.880  -5.393  1.00 41.46  ? 27  PHE A CZ  1 
ATOM   191  N N   . SER A 1 29  ? -46.148 24.863  -7.672  1.00 52.53  ? 28  SER A N   1 
ATOM   192  C CA  . SER A 1 29  ? -44.751 25.214  -7.882  1.00 58.72  ? 28  SER A CA  1 
ATOM   193  C C   . SER A 1 29  ? -43.912 24.762  -6.696  1.00 53.91  ? 28  SER A C   1 
ATOM   194  O O   . SER A 1 29  ? -44.225 25.093  -5.548  1.00 48.24  ? 28  SER A O   1 
ATOM   195  C CB  . SER A 1 29  ? -44.602 26.723  -8.088  1.00 63.10  ? 28  SER A CB  1 
ATOM   196  O OG  . SER A 1 29  ? -45.242 27.440  -7.046  1.00 66.47  ? 28  SER A OG  1 
ATOM   197  N N   . LEU A 1 30  ? -42.840 24.015  -6.976  1.00 52.50  ? 29  LEU A N   1 
ATOM   198  C CA  . LEU A 1 30  ? -41.939 23.590  -5.912  1.00 52.08  ? 29  LEU A CA  1 
ATOM   199  C C   . LEU A 1 30  ? -41.167 24.753  -5.305  1.00 54.27  ? 29  LEU A C   1 
ATOM   200  O O   . LEU A 1 30  ? -40.584 24.597  -4.226  1.00 48.12  ? 29  LEU A O   1 
ATOM   201  C CB  . LEU A 1 30  ? -40.962 22.533  -6.427  1.00 49.85  ? 29  LEU A CB  1 
ATOM   202  C CG  . LEU A 1 30  ? -41.555 21.150  -6.696  1.00 49.34  ? 29  LEU A CG  1 
ATOM   203  C CD1 . LEU A 1 30  ? -40.453 20.131  -6.943  1.00 50.10  ? 29  LEU A CD1 1 
ATOM   204  C CD2 . LEU A 1 30  ? -42.441 20.719  -5.541  1.00 47.40  ? 29  LEU A CD2 1 
ATOM   205  N N   . THR A 1 31  ? -41.139 25.910  -5.970  1.00 50.98  ? 30  THR A N   1 
ATOM   206  C CA  . THR A 1 31  ? -40.498 27.078  -5.379  1.00 54.66  ? 30  THR A CA  1 
ATOM   207  C C   . THR A 1 31  ? -41.325 27.650  -4.237  1.00 58.77  ? 30  THR A C   1 
ATOM   208  O O   . THR A 1 31  ? -40.767 28.240  -3.304  1.00 59.49  ? 30  THR A O   1 
ATOM   209  C CB  . THR A 1 31  ? -40.254 28.151  -6.444  1.00 62.02  ? 30  THR A CB  1 
ATOM   210  O OG1 . THR A 1 31  ? -41.113 27.922  -7.569  1.00 65.07  ? 30  THR A OG1 1 
ATOM   211  C CG2 . THR A 1 31  ? -38.801 28.137  -6.899  1.00 66.19  ? 30  THR A CG2 1 
ATOM   212  N N   . ASP A 1 32  ? -42.646 27.477  -4.288  1.00 58.17  ? 31  ASP A N   1 
ATOM   213  C CA  . ASP A 1 32  ? -43.567 28.041  -3.311  1.00 60.22  ? 31  ASP A CA  1 
ATOM   214  C C   . ASP A 1 32  ? -43.933 27.059  -2.205  1.00 63.54  ? 31  ASP A C   1 
ATOM   215  O O   . ASP A 1 32  ? -43.750 27.361  -1.022  1.00 59.66  ? 31  ASP A O   1 
ATOM   216  C CB  . ASP A 1 32  ? -44.845 28.522  -4.013  1.00 59.64  ? 31  ASP A CB  1 
ATOM   217  C CG  . ASP A 1 32  ? -44.606 29.717  -4.920  1.00 66.88  ? 31  ASP A CG  1 
ATOM   218  O OD1 . ASP A 1 32  ? -43.927 30.672  -4.482  1.00 63.79  ? 31  ASP A OD1 1 
ATOM   219  O OD2 . ASP A 1 32  ? -45.102 29.706  -6.069  1.00 69.83  ? 31  ASP A OD2 1 
ATOM   220  N N   . ASP A 1 33  ? -44.443 25.886  -2.563  1.00 52.82  ? 32  ASP A N   1 
ATOM   221  C CA  . ASP A 1 33  ? -45.024 24.960  -1.604  1.00 47.52  ? 32  ASP A CA  1 
ATOM   222  C C   . ASP A 1 33  ? -44.039 23.863  -1.220  1.00 53.16  ? 32  ASP A C   1 
ATOM   223  O O   . ASP A 1 33  ? -43.224 23.417  -2.031  1.00 48.29  ? 32  ASP A O   1 
ATOM   224  C CB  . ASP A 1 33  ? -46.301 24.337  -2.169  1.00 50.21  ? 32  ASP A CB  1 
ATOM   225  C CG  . ASP A 1 33  ? -47.355 25.376  -2.503  1.00 57.54  ? 32  ASP A CG  1 
ATOM   226  O OD1 . ASP A 1 33  ? -47.552 26.302  -1.687  1.00 48.97  ? 32  ASP A OD1 1 
ATOM   227  O OD2 . ASP A 1 33  ? -47.975 25.276  -3.582  1.00 53.50  ? 32  ASP A OD2 1 
ATOM   228  N N   . GLY A 1 34  ? -44.131 23.424  0.040   1.00 36.13  ? 33  GLY A N   1 
ATOM   229  C CA  . GLY A 1 34  ? -43.311 22.334  0.519   1.00 45.44  ? 33  GLY A CA  1 
ATOM   230  C C   . GLY A 1 34  ? -43.964 20.976  0.318   1.00 43.88  ? 33  GLY A C   1 
ATOM   231  O O   . GLY A 1 34  ? -45.178 20.861  0.168   1.00 42.60  ? 33  GLY A O   1 
ATOM   232  N N   . VAL A 1 35  ? -43.132 19.937  0.315   1.00 43.34  ? 34  VAL A N   1 
ATOM   233  C CA  . VAL A 1 35  ? -43.580 18.566  0.103   1.00 41.23  ? 34  VAL A CA  1 
ATOM   234  C C   . VAL A 1 35  ? -43.051 17.702  1.238   1.00 39.97  ? 34  VAL A C   1 
ATOM   235  O O   . VAL A 1 35  ? -41.848 17.708  1.521   1.00 43.33  ? 34  VAL A O   1 
ATOM   236  C CB  . VAL A 1 35  ? -43.113 18.014  -1.259  1.00 38.21  ? 34  VAL A CB  1 
ATOM   237  C CG1 . VAL A 1 35  ? -43.537 16.563  -1.417  1.00 38.42  ? 34  VAL A CG1 1 
ATOM   238  C CG2 . VAL A 1 35  ? -43.669 18.863  -2.394  1.00 39.65  ? 34  VAL A CG2 1 
ATOM   239  N N   . SER A 1 36  ? -43.951 16.963  1.885   1.00 37.39  ? 35  SER A N   1 
ATOM   240  C CA  . SER A 1 36  ? -43.611 16.069  2.981   1.00 32.40  ? 35  SER A CA  1 
ATOM   241  C C   . SER A 1 36  ? -43.730 14.616  2.543   1.00 41.29  ? 35  SER A C   1 
ATOM   242  O O   . SER A 1 36  ? -44.417 14.286  1.573   1.00 37.78  ? 35  SER A O   1 
ATOM   243  C CB  . SER A 1 36  ? -44.516 16.309  4.196   1.00 40.08  ? 35  SER A CB  1 
ATOM   244  O OG  . SER A 1 36  ? -44.239 17.550  4.819   1.00 39.27  ? 35  SER A OG  1 
ATOM   245  N N   . TRP A 1 37  ? -43.047 13.749  3.283   1.00 43.03  ? 36  TRP A N   1 
ATOM   246  C CA  . TRP A 1 37  ? -43.131 12.308  3.097   1.00 35.71  ? 36  TRP A CA  1 
ATOM   247  C C   . TRP A 1 37  ? -43.764 11.680  4.329   1.00 38.05  ? 36  TRP A C   1 
ATOM   248  O O   . TRP A 1 37  ? -43.297 11.893  5.452   1.00 40.77  ? 36  TRP A O   1 
ATOM   249  C CB  . TRP A 1 37  ? -41.750 11.702  2.837   1.00 39.18  ? 36  TRP A CB  1 
ATOM   250  C CG  . TRP A 1 37  ? -41.207 12.043  1.490   1.00 35.36  ? 36  TRP A CG  1 
ATOM   251  C CD1 . TRP A 1 37  ? -40.275 12.994  1.198   1.00 50.16  ? 36  TRP A CD1 1 
ATOM   252  C CD2 . TRP A 1 37  ? -41.572 11.441  0.245   1.00 39.44  ? 36  TRP A CD2 1 
ATOM   253  N NE1 . TRP A 1 37  ? -40.033 13.019  -0.154  1.00 39.49  ? 36  TRP A NE1 1 
ATOM   254  C CE2 . TRP A 1 37  ? -40.819 12.076  -0.762  1.00 39.31  ? 36  TRP A CE2 1 
ATOM   255  C CE3 . TRP A 1 37  ? -42.463 10.426  -0.118  1.00 40.61  ? 36  TRP A CE3 1 
ATOM   256  C CZ2 . TRP A 1 37  ? -40.927 11.726  -2.107  1.00 45.57  ? 36  TRP A CZ2 1 
ATOM   257  C CZ3 . TRP A 1 37  ? -42.569 10.082  -1.453  1.00 44.31  ? 36  TRP A CZ3 1 
ATOM   258  C CH2 . TRP A 1 37  ? -41.805 10.730  -2.431  1.00 43.52  ? 36  TRP A CH2 1 
ATOM   259  N N   . ILE A 1 38  ? -44.832 10.919  4.111   1.00 29.97  ? 37  ILE A N   1 
ATOM   260  C CA  . ILE A 1 38  ? -45.554 10.217  5.163   1.00 32.61  ? 37  ILE A CA  1 
ATOM   261  C C   . ILE A 1 38  ? -45.606 8.743   4.784   1.00 36.62  ? 37  ILE A C   1 
ATOM   262  O O   . ILE A 1 38  ? -45.581 8.391   3.600   1.00 37.14  ? 37  ILE A O   1 
ATOM   263  C CB  . ILE A 1 38  ? -46.977 10.791  5.369   1.00 33.97  ? 37  ILE A CB  1 
ATOM   264  C CG1 . ILE A 1 38  ? -46.961 12.321  5.346   1.00 38.00  ? 37  ILE A CG1 1 
ATOM   265  C CG2 . ILE A 1 38  ? -47.591 10.291  6.672   1.00 35.37  ? 37  ILE A CG2 1 
ATOM   266  C CD1 . ILE A 1 38  ? -47.284 12.918  3.990   1.00 35.70  ? 37  ILE A CD1 1 
ATOM   267  N N   . ARG A 1 39  ? -45.663 7.877   5.792   1.00 43.15  ? 38  ARG A N   1 
ATOM   268  C CA  . ARG A 1 39  ? -45.821 6.451   5.547   1.00 36.66  ? 38  ARG A CA  1 
ATOM   269  C C   . ARG A 1 39  ? -46.869 5.886   6.494   1.00 49.93  ? 38  ARG A C   1 
ATOM   270  O O   . ARG A 1 39  ? -47.081 6.404   7.593   1.00 42.83  ? 38  ARG A O   1 
ATOM   271  C CB  . ARG A 1 39  ? -44.497 5.690   5.707   1.00 40.25  ? 38  ARG A CB  1 
ATOM   272  C CG  . ARG A 1 39  ? -44.018 5.533   7.140   1.00 44.11  ? 38  ARG A CG  1 
ATOM   273  C CD  . ARG A 1 39  ? -42.758 4.681   7.191   1.00 45.67  ? 38  ARG A CD  1 
ATOM   274  N NE  . ARG A 1 39  ? -42.348 4.368   8.557   1.00 43.30  ? 38  ARG A NE  1 
ATOM   275  C CZ  . ARG A 1 39  ? -41.280 3.639   8.860   1.00 45.61  ? 38  ARG A CZ  1 
ATOM   276  N NH1 . ARG A 1 39  ? -40.516 3.153   7.892   1.00 43.13  ? 38  ARG A NH1 1 
ATOM   277  N NH2 . ARG A 1 39  ? -40.973 3.396   10.126  1.00 49.72  ? 38  ARG A NH2 1 
ATOM   278  N N   . GLN A 1 40  ? -47.523 4.815   6.055   1.00 46.95  ? 39  GLN A N   1 
ATOM   279  C CA  . GLN A 1 40  ? -48.597 4.181   6.816   1.00 44.30  ? 39  GLN A CA  1 
ATOM   280  C C   . GLN A 1 40  ? -48.378 2.675   6.842   1.00 46.37  ? 39  GLN A C   1 
ATOM   281  O O   . GLN A 1 40  ? -48.698 1.982   5.862   1.00 42.58  ? 39  GLN A O   1 
ATOM   282  C CB  . GLN A 1 40  ? -49.955 4.516   6.214   1.00 47.51  ? 39  GLN A CB  1 
ATOM   283  C CG  . GLN A 1 40  ? -51.138 4.213   7.115   1.00 55.71  ? 39  GLN A CG  1 
ATOM   284  C CD  . GLN A 1 40  ? -52.436 4.735   6.538   1.00 55.87  ? 39  GLN A CD  1 
ATOM   285  O OE1 . GLN A 1 40  ? -52.677 4.632   5.335   1.00 52.65  ? 39  GLN A OE1 1 
ATOM   286  N NE2 . GLN A 1 40  ? -53.273 5.314   7.389   1.00 52.88  ? 39  GLN A NE2 1 
ATOM   287  N N   . PRO A 1 41  ? -47.824 2.133   7.933   1.00 52.82  ? 40  PRO A N   1 
ATOM   288  C CA  . PRO A 1 41  ? -47.697 0.681   8.028   1.00 56.29  ? 40  PRO A CA  1 
ATOM   289  C C   . PRO A 1 41  ? -49.067 0.034   8.100   1.00 60.00  ? 40  PRO A C   1 
ATOM   290  O O   . PRO A 1 41  ? -50.047 0.667   8.521   1.00 58.45  ? 40  PRO A O   1 
ATOM   291  C CB  . PRO A 1 41  ? -46.909 0.484   9.339   1.00 50.66  ? 40  PRO A CB  1 
ATOM   292  C CG  . PRO A 1 41  ? -46.240 1.795   9.590   1.00 56.02  ? 40  PRO A CG  1 
ATOM   293  C CD  . PRO A 1 41  ? -47.191 2.823   9.066   1.00 58.88  ? 40  PRO A CD  1 
ATOM   294  N N   . PRO A 1 42  ? -49.185 -1.225  7.676   1.00 69.75  ? 41  PRO A N   1 
ATOM   295  C CA  . PRO A 1 42  ? -50.502 -1.886  7.688   1.00 72.66  ? 41  PRO A CA  1 
ATOM   296  C C   . PRO A 1 42  ? -51.018 -2.055  9.107   1.00 71.68  ? 41  PRO A C   1 
ATOM   297  O O   . PRO A 1 42  ? -50.413 -2.745  9.931   1.00 71.21  ? 41  PRO A O   1 
ATOM   298  C CB  . PRO A 1 42  ? -50.222 -3.238  7.017   1.00 72.88  ? 41  PRO A CB  1 
ATOM   299  C CG  . PRO A 1 42  ? -48.951 -3.035  6.248   1.00 76.49  ? 41  PRO A CG  1 
ATOM   300  C CD  . PRO A 1 42  ? -48.148 -2.066  7.059   1.00 71.94  ? 41  PRO A CD  1 
ATOM   301  N N   . GLY A 1 43  ? -52.146 -1.408  9.394   1.00 73.06  ? 42  GLY A N   1 
ATOM   302  C CA  . GLY A 1 43  ? -52.745 -1.472  10.711  1.00 80.92  ? 42  GLY A CA  1 
ATOM   303  C C   . GLY A 1 43  ? -52.119 -0.570  11.751  1.00 81.59  ? 42  GLY A C   1 
ATOM   304  O O   . GLY A 1 43  ? -52.467 -0.683  12.932  1.00 75.75  ? 42  GLY A O   1 
ATOM   305  N N   . LYS A 1 44  ? -51.212 0.319   11.356  1.00 70.96  ? 43  LYS A N   1 
ATOM   306  C CA  . LYS A 1 44  ? -50.562 1.264   12.251  1.00 66.92  ? 43  LYS A CA  1 
ATOM   307  C C   . LYS A 1 44  ? -51.066 2.678   11.969  1.00 65.59  ? 43  LYS A C   1 
ATOM   308  O O   . LYS A 1 44  ? -51.953 2.900   11.138  1.00 59.67  ? 43  LYS A O   1 
ATOM   309  C CB  . LYS A 1 44  ? -49.040 1.185   12.099  1.00 69.69  ? 43  LYS A CB  1 
ATOM   310  C CG  . LYS A 1 44  ? -48.295 0.650   13.313  1.00 86.61  ? 43  LYS A CG  1 
ATOM   311  C CD  . LYS A 1 44  ? -46.804 0.552   13.012  1.00 101.11 ? 43  LYS A CD  1 
ATOM   312  C CE  . LYS A 1 44  ? -45.972 0.442   14.278  1.00 104.01 ? 43  LYS A CE  1 
ATOM   313  N NZ  . LYS A 1 44  ? -44.515 0.472   13.967  1.00 108.15 ? 43  LYS A NZ  1 
ATOM   314  N N   . GLY A 1 45  ? -50.486 3.648   12.679  1.00 61.22  ? 44  GLY A N   1 
ATOM   315  C CA  . GLY A 1 45  ? -50.802 5.040   12.440  1.00 57.75  ? 44  GLY A CA  1 
ATOM   316  C C   . GLY A 1 45  ? -49.961 5.643   11.326  1.00 54.45  ? 44  GLY A C   1 
ATOM   317  O O   . GLY A 1 45  ? -49.035 5.027   10.807  1.00 55.21  ? 44  GLY A O   1 
ATOM   318  N N   . LEU A 1 46  ? -50.304 6.872   10.956  1.00 36.65  ? 45  LEU A N   1 
ATOM   319  C CA  . LEU A 1 46  ? -49.517 7.607   9.978   1.00 31.66  ? 45  LEU A CA  1 
ATOM   320  C C   . LEU A 1 46  ? -48.232 8.113   10.618  1.00 31.06  ? 45  LEU A C   1 
ATOM   321  O O   . LEU A 1 46  ? -48.217 8.502   11.789  1.00 38.05  ? 45  LEU A O   1 
ATOM   322  C CB  . LEU A 1 46  ? -50.318 8.778   9.411   1.00 35.73  ? 45  LEU A CB  1 
ATOM   323  C CG  . LEU A 1 46  ? -51.407 8.429   8.398   1.00 38.04  ? 45  LEU A CG  1 
ATOM   324  C CD1 . LEU A 1 46  ? -52.216 9.656   8.062   1.00 36.22  ? 45  LEU A CD1 1 
ATOM   325  C CD2 . LEU A 1 46  ? -50.787 7.854   7.144   1.00 36.51  ? 45  LEU A CD2 1 
ATOM   326  N N   . GLU A 1 47  ? -47.149 8.110   9.842   1.00 38.66  ? 46  GLU A N   1 
ATOM   327  C CA  . GLU A 1 47  ? -45.830 8.477   10.344  1.00 36.08  ? 46  GLU A CA  1 
ATOM   328  C C   . GLU A 1 47  ? -45.194 9.478   9.393   1.00 35.89  ? 46  GLU A C   1 
ATOM   329  O O   . GLU A 1 47  ? -44.987 9.172   8.215   1.00 31.23  ? 46  GLU A O   1 
ATOM   330  C CB  . GLU A 1 47  ? -44.939 7.243   10.502  1.00 41.92  ? 46  GLU A CB  1 
ATOM   331  C CG  . GLU A 1 47  ? -43.707 7.477   11.356  1.00 53.42  ? 46  GLU A CG  1 
ATOM   332  C CD  . GLU A 1 47  ? -43.179 6.197   11.973  1.00 58.29  ? 46  GLU A CD  1 
ATOM   333  O OE1 . GLU A 1 47  ? -43.425 5.111   11.402  1.00 41.40  ? 46  GLU A OE1 1 
ATOM   334  O OE2 . GLU A 1 47  ? -42.527 6.276   13.035  1.00 48.20  ? 46  GLU A OE2 1 
ATOM   335  N N   . TRP A 1 48  ? -44.880 10.663  9.911   1.00 35.58  ? 47  TRP A N   1 
ATOM   336  C CA  . TRP A 1 48  ? -44.259 11.713  9.118   1.00 34.73  ? 47  TRP A CA  1 
ATOM   337  C C   . TRP A 1 48  ? -42.752 11.501  9.093   1.00 37.99  ? 47  TRP A C   1 
ATOM   338  O O   . TRP A 1 48  ? -42.126 11.290  10.137  1.00 34.49  ? 47  TRP A O   1 
ATOM   339  C CB  . TRP A 1 48  ? -44.610 13.079  9.704   1.00 40.23  ? 47  TRP A CB  1 
ATOM   340  C CG  . TRP A 1 48  ? -44.032 14.255  8.985   1.00 38.02  ? 47  TRP A CG  1 
ATOM   341  C CD1 . TRP A 1 48  ? -44.536 14.872  7.879   1.00 36.53  ? 47  TRP A CD1 1 
ATOM   342  C CD2 . TRP A 1 48  ? -42.856 14.982  9.351   1.00 31.48  ? 47  TRP A CD2 1 
ATOM   343  N NE1 . TRP A 1 48  ? -43.736 15.932  7.523   1.00 33.05  ? 47  TRP A NE1 1 
ATOM   344  C CE2 . TRP A 1 48  ? -42.698 16.020  8.413   1.00 35.65  ? 47  TRP A CE2 1 
ATOM   345  C CE3 . TRP A 1 48  ? -41.916 14.851  10.376  1.00 35.83  ? 47  TRP A CE3 1 
ATOM   346  C CZ2 . TRP A 1 48  ? -41.638 16.921  8.471   1.00 36.66  ? 47  TRP A CZ2 1 
ATOM   347  C CZ3 . TRP A 1 48  ? -40.866 15.745  10.432  1.00 35.35  ? 47  TRP A CZ3 1 
ATOM   348  C CH2 . TRP A 1 48  ? -40.734 16.766  9.485   1.00 43.92  ? 47  TRP A CH2 1 
ATOM   349  N N   . LEU A 1 49  ? -42.174 11.535  7.894   1.00 35.73  ? 48  LEU A N   1 
ATOM   350  C CA  . LEU A 1 49  ? -40.752 11.276  7.708   1.00 36.14  ? 48  LEU A CA  1 
ATOM   351  C C   . LEU A 1 49  ? -39.931 12.555  7.613   1.00 40.81  ? 48  LEU A C   1 
ATOM   352  O O   . LEU A 1 49  ? -38.899 12.680  8.276   1.00 40.12  ? 48  LEU A O   1 
ATOM   353  C CB  . LEU A 1 49  ? -40.529 10.430  6.449   1.00 42.24  ? 48  LEU A CB  1 
ATOM   354  C CG  . LEU A 1 49  ? -41.405 9.184   6.291   1.00 49.36  ? 48  LEU A CG  1 
ATOM   355  C CD1 . LEU A 1 49  ? -41.187 8.566   4.928   1.00 43.75  ? 48  LEU A CD1 1 
ATOM   356  C CD2 . LEU A 1 49  ? -41.120 8.178   7.388   1.00 38.34  ? 48  LEU A CD2 1 
ATOM   357  N N   . GLY A 1 50  ? -40.364 13.498  6.788   1.00 36.78  ? 49  GLY A N   1 
ATOM   358  C CA  . GLY A 1 50  ? -39.608 14.719  6.600   1.00 36.44  ? 49  GLY A CA  1 
ATOM   359  C C   . GLY A 1 50  ? -40.306 15.610  5.600   1.00 36.62  ? 49  GLY A C   1 
ATOM   360  O O   . GLY A 1 50  ? -41.358 15.268  5.053   1.00 38.01  ? 49  GLY A O   1 
ATOM   361  N N   . VAL A 1 51  ? -39.693 16.766  5.364   1.00 38.46  ? 50  VAL A N   1 
ATOM   362  C CA  . VAL A 1 51  ? -40.266 17.785  4.495   1.00 32.17  ? 50  VAL A CA  1 
ATOM   363  C C   . VAL A 1 51  ? -39.128 18.547  3.837   1.00 39.46  ? 50  VAL A C   1 
ATOM   364  O O   . VAL A 1 51  ? -38.063 18.738  4.434   1.00 37.12  ? 50  VAL A O   1 
ATOM   365  C CB  . VAL A 1 51  ? -41.201 18.733  5.281   1.00 38.14  ? 50  VAL A CB  1 
ATOM   366  C CG1 . VAL A 1 51  ? -40.429 19.464  6.373   1.00 39.86  ? 50  VAL A CG1 1 
ATOM   367  C CG2 . VAL A 1 51  ? -41.884 19.721  4.349   1.00 33.69  ? 50  VAL A CG2 1 
ATOM   368  N N   . ILE A 1 52  ? -39.344 18.944  2.589   1.00 41.28  ? 51  ILE A N   1 
ATOM   369  C CA  . ILE A 1 52  ? -38.520 19.933  1.910   1.00 44.67  ? 51  ILE A CA  1 
ATOM   370  C C   . ILE A 1 52  ? -39.406 21.138  1.631   1.00 49.66  ? 51  ILE A C   1 
ATOM   371  O O   . ILE A 1 52  ? -40.471 21.008  1.013   1.00 43.47  ? 51  ILE A O   1 
ATOM   372  C CB  . ILE A 1 52  ? -37.904 19.378  0.618   1.00 43.56  ? 51  ILE A CB  1 
ATOM   373  C CG1 . ILE A 1 52  ? -37.258 20.507  -0.188  1.00 46.19  ? 51  ILE A CG1 1 
ATOM   374  C CG2 . ILE A 1 52  ? -38.950 18.638  -0.213  1.00 45.32  ? 51  ILE A CG2 1 
ATOM   375  C CD1 . ILE A 1 52  ? -35.836 20.221  -0.611  1.00 48.40  ? 51  ILE A CD1 1 
ATOM   376  N N   . TRP A 1 53  ? -38.987 22.304  2.105   1.00 40.56  ? 52  TRP A N   1 
ATOM   377  C CA  . TRP A 1 53  ? -39.798 23.501  1.965   1.00 41.18  ? 52  TRP A CA  1 
ATOM   378  C C   . TRP A 1 53  ? -39.504 24.196  0.637   1.00 42.17  ? 52  TRP A C   1 
ATOM   379  O O   . TRP A 1 53  ? -38.570 23.842  -0.086  1.00 43.45  ? 52  TRP A O   1 
ATOM   380  C CB  . TRP A 1 53  ? -39.560 24.445  3.141   1.00 39.83  ? 52  TRP A CB  1 
ATOM   381  C CG  . TRP A 1 53  ? -39.932 23.844  4.463   1.00 36.61  ? 52  TRP A CG  1 
ATOM   382  C CD1 . TRP A 1 53  ? -39.085 23.484  5.469   1.00 41.15  ? 52  TRP A CD1 1 
ATOM   383  C CD2 . TRP A 1 53  ? -41.252 23.522  4.916   1.00 37.63  ? 52  TRP A CD2 1 
ATOM   384  N NE1 . TRP A 1 53  ? -39.796 22.964  6.524   1.00 41.35  ? 52  TRP A NE1 1 
ATOM   385  C CE2 . TRP A 1 53  ? -41.129 22.977  6.208   1.00 37.63  ? 52  TRP A CE2 1 
ATOM   386  C CE3 . TRP A 1 53  ? -42.527 23.646  4.355   1.00 41.44  ? 52  TRP A CE3 1 
ATOM   387  C CZ2 . TRP A 1 53  ? -42.231 22.555  6.948   1.00 38.74  ? 52  TRP A CZ2 1 
ATOM   388  C CZ3 . TRP A 1 53  ? -43.618 23.226  5.090   1.00 35.76  ? 52  TRP A CZ3 1 
ATOM   389  C CH2 . TRP A 1 53  ? -43.464 22.688  6.371   1.00 45.41  ? 52  TRP A CH2 1 
ATOM   390  N N   . GLY A 1 54  ? -40.330 25.197  0.319   1.00 49.10  ? 53  GLY A N   1 
ATOM   391  C CA  . GLY A 1 54  ? -40.201 25.886  -0.956  1.00 47.93  ? 53  GLY A CA  1 
ATOM   392  C C   . GLY A 1 54  ? -38.838 26.512  -1.170  1.00 53.25  ? 53  GLY A C   1 
ATOM   393  O O   . GLY A 1 54  ? -38.367 26.610  -2.307  1.00 54.39  ? 53  GLY A O   1 
ATOM   394  N N   . GLY A 1 55  ? -38.187 26.944  -0.092  1.00 48.84  ? 54  GLY A N   1 
ATOM   395  C CA  . GLY A 1 55  ? -36.837 27.460  -0.195  1.00 49.46  ? 54  GLY A CA  1 
ATOM   396  C C   . GLY A 1 55  ? -35.748 26.413  -0.182  1.00 56.44  ? 54  GLY A C   1 
ATOM   397  O O   . GLY A 1 55  ? -34.581 26.755  -0.392  1.00 49.42  ? 54  GLY A O   1 
ATOM   398  N N   . GLY A 1 56  ? -36.097 25.150  0.057   1.00 44.96  ? 55  GLY A N   1 
ATOM   399  C CA  . GLY A 1 56  ? -35.128 24.073  0.091   1.00 45.52  ? 55  GLY A CA  1 
ATOM   400  C C   . GLY A 1 56  ? -34.779 23.559  1.470   1.00 49.37  ? 55  GLY A C   1 
ATOM   401  O O   . GLY A 1 56  ? -34.040 22.570  1.569   1.00 47.42  ? 55  GLY A O   1 
ATOM   402  N N   . SER A 1 57  ? -35.277 24.188  2.534   1.00 41.92  ? 56  SER A N   1 
ATOM   403  C CA  . SER A 1 57  ? -34.992 23.719  3.884   1.00 49.89  ? 56  SER A CA  1 
ATOM   404  C C   . SER A 1 57  ? -35.553 22.317  4.089   1.00 48.21  ? 56  SER A C   1 
ATOM   405  O O   . SER A 1 57  ? -36.731 22.063  3.826   1.00 44.64  ? 56  SER A O   1 
ATOM   406  C CB  . SER A 1 57  ? -35.589 24.679  4.909   1.00 47.60  ? 56  SER A CB  1 
ATOM   407  O OG  . SER A 1 57  ? -36.046 25.865  4.281   1.00 45.66  ? 56  SER A OG  1 
ATOM   408  N N   . THR A 1 58  ? -34.705 21.404  4.556   1.00 49.59  ? 57  THR A N   1 
ATOM   409  C CA  . THR A 1 58  ? -35.090 20.014  4.769   1.00 42.50  ? 57  THR A CA  1 
ATOM   410  C C   . THR A 1 58  ? -35.079 19.707  6.260   1.00 47.12  ? 57  THR A C   1 
ATOM   411  O O   . THR A 1 58  ? -34.055 19.880  6.929   1.00 46.28  ? 57  THR A O   1 
ATOM   412  C CB  . THR A 1 58  ? -34.158 19.059  4.020   1.00 48.46  ? 57  THR A CB  1 
ATOM   413  O OG1 . THR A 1 58  ? -32.812 19.547  4.081   1.00 59.96  ? 57  THR A OG1 1 
ATOM   414  C CG2 . THR A 1 58  ? -34.586 18.926  2.568   1.00 44.05  ? 57  THR A CG2 1 
ATOM   415  N N   . TYR A 1 59  ? -36.220 19.255  6.774   1.00 40.65  ? 58  TYR A N   1 
ATOM   416  C CA  . TYR A 1 59  ? -36.339 18.776  8.141   1.00 41.14  ? 58  TYR A CA  1 
ATOM   417  C C   . TYR A 1 59  ? -36.756 17.313  8.111   1.00 45.72  ? 58  TYR A C   1 
ATOM   418  O O   . TYR A 1 59  ? -37.450 16.871  7.192   1.00 44.59  ? 58  TYR A O   1 
ATOM   419  C CB  . TYR A 1 59  ? -37.350 19.606  8.943   1.00 39.68  ? 58  TYR A CB  1 
ATOM   420  C CG  . TYR A 1 59  ? -36.960 21.060  9.095   1.00 45.43  ? 58  TYR A CG  1 
ATOM   421  C CD1 . TYR A 1 59  ? -36.373 21.526  10.265  1.00 50.10  ? 58  TYR A CD1 1 
ATOM   422  C CD2 . TYR A 1 59  ? -37.171 21.966  8.063   1.00 49.62  ? 58  TYR A CD2 1 
ATOM   423  C CE1 . TYR A 1 59  ? -36.012 22.856  10.403  1.00 47.14  ? 58  TYR A CE1 1 
ATOM   424  C CE2 . TYR A 1 59  ? -36.813 23.294  8.192   1.00 46.39  ? 58  TYR A CE2 1 
ATOM   425  C CZ  . TYR A 1 59  ? -36.235 23.733  9.362   1.00 53.52  ? 58  TYR A CZ  1 
ATOM   426  O OH  . TYR A 1 59  ? -35.880 25.055  9.489   1.00 45.88  ? 58  TYR A OH  1 
ATOM   427  N N   . PHE A 1 60  ? -36.318 16.560  9.115   1.00 41.41  ? 59  PHE A N   1 
ATOM   428  C CA  . PHE A 1 60  ? -36.548 15.125  9.157   1.00 41.06  ? 59  PHE A CA  1 
ATOM   429  C C   . PHE A 1 60  ? -37.104 14.724  10.513  1.00 44.96  ? 59  PHE A C   1 
ATOM   430  O O   . PHE A 1 60  ? -36.868 15.394  11.523  1.00 41.69  ? 59  PHE A O   1 
ATOM   431  C CB  . PHE A 1 60  ? -35.254 14.342  8.878   1.00 44.66  ? 59  PHE A CB  1 
ATOM   432  C CG  . PHE A 1 60  ? -34.589 14.714  7.583   1.00 42.22  ? 59  PHE A CG  1 
ATOM   433  C CD1 . PHE A 1 60  ? -34.870 14.020  6.419   1.00 48.15  ? 59  PHE A CD1 1 
ATOM   434  C CD2 . PHE A 1 60  ? -33.682 15.762  7.529   1.00 56.86  ? 59  PHE A CD2 1 
ATOM   435  C CE1 . PHE A 1 60  ? -34.264 14.359  5.227   1.00 45.54  ? 59  PHE A CE1 1 
ATOM   436  C CE2 . PHE A 1 60  ? -33.072 16.108  6.337   1.00 43.25  ? 59  PHE A CE2 1 
ATOM   437  C CZ  . PHE A 1 60  ? -33.364 15.404  5.185   1.00 52.69  ? 59  PHE A CZ  1 
ATOM   438  N N   . ASN A 1 61  ? -37.857 13.628  10.523  1.00 45.02  ? 60  ASN A N   1 
ATOM   439  C CA  . ASN A 1 61  ? -38.274 13.028  11.782  1.00 40.41  ? 60  ASN A CA  1 
ATOM   440  C C   . ASN A 1 61  ? -37.057 12.422  12.467  1.00 46.72  ? 60  ASN A C   1 
ATOM   441  O O   . ASN A 1 61  ? -36.252 11.737  11.830  1.00 45.55  ? 60  ASN A O   1 
ATOM   442  C CB  . ASN A 1 61  ? -39.344 11.964  11.540  1.00 42.34  ? 60  ASN A CB  1 
ATOM   443  C CG  . ASN A 1 61  ? -40.061 11.550  12.817  1.00 47.98  ? 60  ASN A CG  1 
ATOM   444  O OD1 . ASN A 1 61  ? -39.477 11.537  13.900  1.00 49.91  ? 60  ASN A OD1 1 
ATOM   445  N ND2 . ASN A 1 61  ? -41.339 11.211  12.690  1.00 47.55  ? 60  ASN A ND2 1 
ATOM   446  N N   . SER A 1 62  ? -36.922 12.682  13.770  1.00 46.52  ? 61  SER A N   1 
ATOM   447  C CA  . SER A 1 62  ? -35.738 12.237  14.499  1.00 49.54  ? 61  SER A CA  1 
ATOM   448  C C   . SER A 1 62  ? -35.572 10.723  14.456  1.00 56.32  ? 61  SER A C   1 
ATOM   449  O O   . SER A 1 62  ? -34.444 10.224  14.534  1.00 51.28  ? 61  SER A O   1 
ATOM   450  C CB  . SER A 1 62  ? -35.807 12.723  15.947  1.00 48.67  ? 61  SER A CB  1 
ATOM   451  O OG  . SER A 1 62  ? -37.071 12.434  16.525  1.00 73.63  ? 61  SER A OG  1 
ATOM   452  N N   . LEU A 1 63  ? -36.672 9.979   14.322  1.00 50.78  ? 62  LEU A N   1 
ATOM   453  C CA  . LEU A 1 63  ? -36.595 8.522   14.338  1.00 50.15  ? 62  LEU A CA  1 
ATOM   454  C C   . LEU A 1 63  ? -35.880 7.955   13.119  1.00 45.93  ? 62  LEU A C   1 
ATOM   455  O O   . LEU A 1 63  ? -35.477 6.786   13.142  1.00 47.21  ? 62  LEU A O   1 
ATOM   456  C CB  . LEU A 1 63  ? -37.999 7.923   14.435  1.00 56.38  ? 62  LEU A CB  1 
ATOM   457  C CG  . LEU A 1 63  ? -38.740 8.121   15.758  1.00 61.19  ? 62  LEU A CG  1 
ATOM   458  C CD1 . LEU A 1 63  ? -40.103 8.752   15.516  1.00 62.49  ? 62  LEU A CD1 1 
ATOM   459  C CD2 . LEU A 1 63  ? -38.886 6.797   16.492  1.00 62.50  ? 62  LEU A CD2 1 
ATOM   460  N N   . PHE A 1 64  ? -35.711 8.746   12.061  1.00 52.76  ? 63  PHE A N   1 
ATOM   461  C CA  . PHE A 1 64  ? -35.070 8.273   10.839  1.00 52.99  ? 63  PHE A CA  1 
ATOM   462  C C   . PHE A 1 64  ? -33.768 9.015   10.570  1.00 54.77  ? 63  PHE A C   1 
ATOM   463  O O   . PHE A 1 64  ? -32.714 8.375   10.503  1.00 55.08  ? 63  PHE A O   1 
ATOM   464  C CB  . PHE A 1 64  ? -36.052 8.399   9.667   1.00 52.68  ? 63  PHE A CB  1 
ATOM   465  C CG  . PHE A 1 64  ? -37.382 7.743   9.928   1.00 52.44  ? 63  PHE A CG  1 
ATOM   466  C CD1 . PHE A 1 64  ? -37.588 6.410   9.613   1.00 57.34  ? 63  PHE A CD1 1 
ATOM   467  C CD2 . PHE A 1 64  ? -38.422 8.455   10.507  1.00 52.33  ? 63  PHE A CD2 1 
ATOM   468  C CE1 . PHE A 1 64  ? -38.807 5.803   9.861   1.00 50.26  ? 63  PHE A CE1 1 
ATOM   469  C CE2 . PHE A 1 64  ? -39.642 7.855   10.758  1.00 59.42  ? 63  PHE A CE2 1 
ATOM   470  C CZ  . PHE A 1 64  ? -39.834 6.527   10.432  1.00 55.55  ? 63  PHE A CZ  1 
ATOM   471  N N   . LYS A 1 65  ? -33.818 10.343  10.409  1.00 56.98  ? 64  LYS A N   1 
ATOM   472  C CA  . LYS A 1 65  ? -32.668 11.251  10.441  1.00 62.40  ? 64  LYS A CA  1 
ATOM   473  C C   . LYS A 1 65  ? -31.401 10.683  9.812   1.00 62.91  ? 64  LYS A C   1 
ATOM   474  O O   . LYS A 1 65  ? -30.904 11.206  8.809   1.00 62.47  ? 64  LYS A O   1 
ATOM   475  C CB  . LYS A 1 65  ? -32.370 11.659  11.890  1.00 65.32  ? 64  LYS A CB  1 
ATOM   476  C CG  . LYS A 1 65  ? -31.406 12.836  12.022  1.00 75.14  ? 64  LYS A CG  1 
ATOM   477  C CD  . LYS A 1 65  ? -31.021 13.117  13.475  1.00 87.53  ? 64  LYS A CD  1 
ATOM   478  C CE  . LYS A 1 65  ? -29.762 12.361  13.895  1.00 100.61 ? 64  LYS A CE  1 
ATOM   479  N NZ  . LYS A 1 65  ? -30.045 10.976  14.374  1.00 109.06 ? 64  LYS A NZ  1 
ATOM   480  N N   . SER A 1 66  ? -30.872 9.615   10.414  1.00 59.75  ? 65  SER A N   1 
ATOM   481  C CA  . SER A 1 66  ? -29.619 9.025   9.956   1.00 64.77  ? 65  SER A CA  1 
ATOM   482  C C   . SER A 1 66  ? -29.727 8.493   8.532   1.00 61.03  ? 65  SER A C   1 
ATOM   483  O O   . SER A 1 66  ? -28.759 8.557   7.766   1.00 64.43  ? 65  SER A O   1 
ATOM   484  C CB  . SER A 1 66  ? -29.202 7.909   10.914  1.00 68.56  ? 65  SER A CB  1 
ATOM   485  O OG  . SER A 1 66  ? -30.329 7.159   11.340  1.00 72.68  ? 65  SER A OG  1 
ATOM   486  N N   . ARG A 1 67  ? -30.892 7.969   8.152   1.00 58.32  ? 66  ARG A N   1 
ATOM   487  C CA  . ARG A 1 67  ? -31.015 7.228   6.903   1.00 57.46  ? 66  ARG A CA  1 
ATOM   488  C C   . ARG A 1 67  ? -31.948 7.879   5.888   1.00 53.82  ? 66  ARG A C   1 
ATOM   489  O O   . ARG A 1 67  ? -32.236 7.266   4.857   1.00 53.92  ? 66  ARG A O   1 
ATOM   490  C CB  . ARG A 1 67  ? -31.467 5.792   7.189   1.00 66.21  ? 66  ARG A CB  1 
ATOM   491  C CG  . ARG A 1 67  ? -32.741 5.663   8.015   1.00 63.91  ? 66  ARG A CG  1 
ATOM   492  C CD  . ARG A 1 67  ? -32.806 4.290   8.683   1.00 65.90  ? 66  ARG A CD  1 
ATOM   493  N NE  . ARG A 1 67  ? -34.093 4.025   9.321   1.00 63.79  ? 66  ARG A NE  1 
ATOM   494  C CZ  . ARG A 1 67  ? -34.989 3.154   8.866   1.00 62.77  ? 66  ARG A CZ  1 
ATOM   495  N NH1 . ARG A 1 67  ? -34.740 2.454   7.768   1.00 60.75  ? 66  ARG A NH1 1 
ATOM   496  N NH2 . ARG A 1 67  ? -36.132 2.975   9.514   1.00 55.20  ? 66  ARG A NH2 1 
ATOM   497  N N   . LEU A 1 68  ? -32.409 9.103   6.128   1.00 52.01  ? 67  LEU A N   1 
ATOM   498  C CA  . LEU A 1 68  ? -33.332 9.751   5.208   1.00 52.77  ? 67  LEU A CA  1 
ATOM   499  C C   . LEU A 1 68  ? -32.633 10.841  4.402   1.00 57.28  ? 67  LEU A C   1 
ATOM   500  O O   . LEU A 1 68  ? -31.687 11.481  4.868   1.00 55.27  ? 67  LEU A O   1 
ATOM   501  C CB  . LEU A 1 68  ? -34.528 10.347  5.954   1.00 55.81  ? 67  LEU A CB  1 
ATOM   502  C CG  . LEU A 1 68  ? -35.865 10.170  5.230   1.00 56.52  ? 67  LEU A CG  1 
ATOM   503  C CD1 . LEU A 1 68  ? -36.548 8.888   5.678   1.00 55.19  ? 67  LEU A CD1 1 
ATOM   504  C CD2 . LEU A 1 68  ? -36.781 11.370  5.422   1.00 58.97  ? 67  LEU A CD2 1 
ATOM   505  N N   . SER A 1 69  ? -33.116 11.040  3.178   1.00 53.49  ? 68  SER A N   1 
ATOM   506  C CA  . SER A 1 69  ? -32.646 12.102  2.299   1.00 56.51  ? 68  SER A CA  1 
ATOM   507  C C   . SER A 1 69  ? -33.815 12.571  1.451   1.00 56.55  ? 68  SER A C   1 
ATOM   508  O O   . SER A 1 69  ? -34.508 11.752  0.841   1.00 50.08  ? 68  SER A O   1 
ATOM   509  C CB  . SER A 1 69  ? -31.496 11.630  1.400   1.00 55.07  ? 68  SER A CB  1 
ATOM   510  O OG  . SER A 1 69  ? -30.315 11.399  2.148   1.00 61.33  ? 68  SER A OG  1 
ATOM   511  N N   . ILE A 1 70  ? -34.037 13.881  1.420   1.00 46.48  ? 69  ILE A N   1 
ATOM   512  C CA  . ILE A 1 70  ? -35.129 14.473  0.658   1.00 46.55  ? 69  ILE A CA  1 
ATOM   513  C C   . ILE A 1 70  ? -34.540 15.548  -0.244  1.00 51.60  ? 69  ILE A C   1 
ATOM   514  O O   . ILE A 1 70  ? -34.031 16.566  0.243   1.00 50.47  ? 69  ILE A O   1 
ATOM   515  C CB  . ILE A 1 70  ? -36.221 15.051  1.564   1.00 53.26  ? 69  ILE A CB  1 
ATOM   516  C CG1 . ILE A 1 70  ? -36.738 13.972  2.521   1.00 45.93  ? 69  ILE A CG1 1 
ATOM   517  C CG2 . ILE A 1 70  ? -37.374 15.581  0.738   1.00 44.97  ? 69  ILE A CG2 1 
ATOM   518  C CD1 . ILE A 1 70  ? -37.888 14.427  3.386   1.00 49.40  ? 69  ILE A CD1 1 
ATOM   519  N N   . THR A 1 71  ? -34.594 15.319  -1.553  1.00 47.83  ? 70  THR A N   1 
ATOM   520  C CA  . THR A 1 71  ? -34.104 16.249  -2.559  1.00 51.83  ? 70  THR A CA  1 
ATOM   521  C C   . THR A 1 71  ? -35.230 16.524  -3.549  1.00 53.90  ? 70  THR A C   1 
ATOM   522  O O   . THR A 1 71  ? -36.347 16.022  -3.397  1.00 50.16  ? 70  THR A O   1 
ATOM   523  C CB  . THR A 1 71  ? -32.866 15.694  -3.275  1.00 56.80  ? 70  THR A CB  1 
ATOM   524  O OG1 . THR A 1 71  ? -33.206 14.474  -3.945  1.00 55.63  ? 70  THR A OG1 1 
ATOM   525  C CG2 . THR A 1 71  ? -31.751 15.423  -2.279  1.00 56.55  ? 70  THR A CG2 1 
ATOM   526  N N   . ARG A 1 72  ? -34.937 17.316  -4.578  1.00 51.36  ? 71  ARG A N   1 
ATOM   527  C CA  . ARG A 1 72  ? -35.947 17.631  -5.582  1.00 51.87  ? 71  ARG A CA  1 
ATOM   528  C C   . ARG A 1 72  ? -35.271 18.097  -6.868  1.00 54.40  ? 71  ARG A C   1 
ATOM   529  O O   . ARG A 1 72  ? -34.044 18.204  -6.953  1.00 54.43  ? 71  ARG A O   1 
ATOM   530  C CB  . ARG A 1 72  ? -36.934 18.681  -5.064  1.00 49.49  ? 71  ARG A CB  1 
ATOM   531  C CG  . ARG A 1 72  ? -36.336 20.060  -4.838  1.00 56.95  ? 71  ARG A CG  1 
ATOM   532  C CD  . ARG A 1 72  ? -37.398 21.024  -4.332  1.00 57.74  ? 71  ARG A CD  1 
ATOM   533  N NE  . ARG A 1 72  ? -36.905 22.392  -4.203  1.00 62.55  ? 71  ARG A NE  1 
ATOM   534  C CZ  . ARG A 1 72  ? -37.636 23.404  -3.748  1.00 61.22  ? 71  ARG A CZ  1 
ATOM   535  N NH1 . ARG A 1 72  ? -38.891 23.199  -3.376  1.00 54.74  ? 71  ARG A NH1 1 
ATOM   536  N NH2 . ARG A 1 72  ? -37.113 24.621  -3.663  1.00 58.65  ? 71  ARG A NH2 1 
ATOM   537  N N   . ASP A 1 73  ? -36.104 18.369  -7.877  1.00 50.46  ? 72  ASP A N   1 
ATOM   538  C CA  . ASP A 1 73  ? -35.656 18.837  -9.187  1.00 58.54  ? 72  ASP A CA  1 
ATOM   539  C C   . ASP A 1 73  ? -36.802 19.672  -9.753  1.00 60.08  ? 72  ASP A C   1 
ATOM   540  O O   . ASP A 1 73  ? -37.745 19.123  -10.330 1.00 54.90  ? 72  ASP A O   1 
ATOM   541  C CB  . ASP A 1 73  ? -35.299 17.669  -10.099 1.00 59.44  ? 72  ASP A CB  1 
ATOM   542  C CG  . ASP A 1 73  ? -34.539 18.102  -11.342 1.00 68.28  ? 72  ASP A CG  1 
ATOM   543  O OD1 . ASP A 1 73  ? -34.896 19.139  -11.943 1.00 66.19  ? 72  ASP A OD1 1 
ATOM   544  O OD2 . ASP A 1 73  ? -33.578 17.398  -11.716 1.00 75.06  ? 72  ASP A OD2 1 
ATOM   545  N N   . ASN A 1 74  ? -36.703 20.995  -9.583  1.00 55.56  ? 73  ASN A N   1 
ATOM   546  C CA  . ASN A 1 74  ? -37.826 21.883  -9.876  1.00 56.16  ? 73  ASN A CA  1 
ATOM   547  C C   . ASN A 1 74  ? -38.157 21.923  -11.363 1.00 63.72  ? 73  ASN A C   1 
ATOM   548  O O   . ASN A 1 74  ? -39.324 22.107  -11.730 1.00 56.10  ? 73  ASN A O   1 
ATOM   549  C CB  . ASN A 1 74  ? -37.519 23.290  -9.366  1.00 65.23  ? 73  ASN A CB  1 
ATOM   550  C CG  . ASN A 1 74  ? -36.588 23.285  -8.168  1.00 81.42  ? 73  ASN A CG  1 
ATOM   551  O OD1 . ASN A 1 74  ? -35.791 22.364  -7.993  1.00 94.48  ? 73  ASN A OD1 1 
ATOM   552  N ND2 . ASN A 1 74  ? -36.685 24.316  -7.334  1.00 102.00 ? 73  ASN A ND2 1 
ATOM   553  N N   . SER A 1 75  ? -37.151 21.773  -12.228 1.00 54.64  ? 74  SER A N   1 
ATOM   554  C CA  . SER A 1 75  ? -37.416 21.722  -13.662 1.00 61.23  ? 74  SER A CA  1 
ATOM   555  C C   . SER A 1 75  ? -38.259 20.502  -14.011 1.00 61.41  ? 74  SER A C   1 
ATOM   556  O O   . SER A 1 75  ? -39.246 20.603  -14.748 1.00 61.17  ? 74  SER A O   1 
ATOM   557  C CB  . SER A 1 75  ? -36.098 21.710  -14.437 1.00 60.41  ? 74  SER A CB  1 
ATOM   558  O OG  . SER A 1 75  ? -35.323 20.569  -14.110 1.00 62.95  ? 74  SER A OG  1 
ATOM   559  N N   . LYS A 1 76  ? -37.892 19.338  -13.473 1.00 58.19  ? 75  LYS A N   1 
ATOM   560  C CA  . LYS A 1 76  ? -38.652 18.118  -13.702 1.00 60.44  ? 75  LYS A CA  1 
ATOM   561  C C   . LYS A 1 76  ? -39.926 18.045  -12.870 1.00 57.92  ? 75  LYS A C   1 
ATOM   562  O O   . LYS A 1 76  ? -40.758 17.167  -13.127 1.00 54.39  ? 75  LYS A O   1 
ATOM   563  C CB  . LYS A 1 76  ? -37.790 16.888  -13.402 1.00 61.91  ? 75  LYS A CB  1 
ATOM   564  C CG  . LYS A 1 76  ? -36.423 16.884  -14.069 1.00 66.28  ? 75  LYS A CG  1 
ATOM   565  C CD  . LYS A 1 76  ? -36.026 15.471  -14.481 1.00 73.83  ? 75  LYS A CD  1 
ATOM   566  C CE  . LYS A 1 76  ? -34.566 15.173  -14.175 1.00 81.90  ? 75  LYS A CE  1 
ATOM   567  N NZ  . LYS A 1 76  ? -34.421 14.342  -12.945 1.00 94.16  ? 75  LYS A NZ  1 
ATOM   568  N N   . SER A 1 77  ? -40.094 18.940  -11.890 1.00 53.96  ? 76  SER A N   1 
ATOM   569  C CA  . SER A 1 77  ? -41.218 18.904  -10.949 1.00 54.96  ? 76  SER A CA  1 
ATOM   570  C C   . SER A 1 77  ? -41.267 17.571  -10.205 1.00 50.44  ? 76  SER A C   1 
ATOM   571  O O   . SER A 1 77  ? -42.278 16.869  -10.203 1.00 45.68  ? 76  SER A O   1 
ATOM   572  C CB  . SER A 1 77  ? -42.550 19.182  -11.650 1.00 59.75  ? 76  SER A CB  1 
ATOM   573  O OG  . SER A 1 77  ? -42.673 20.548  -12.002 1.00 55.46  ? 76  SER A OG  1 
ATOM   574  N N   . GLN A 1 78  ? -40.158 17.224  -9.559  1.00 48.54  ? 77  GLN A N   1 
ATOM   575  C CA  . GLN A 1 78  ? -40.048 15.943  -8.879  1.00 48.29  ? 77  GLN A CA  1 
ATOM   576  C C   . GLN A 1 78  ? -39.386 16.118  -7.522  1.00 46.45  ? 77  GLN A C   1 
ATOM   577  O O   . GLN A 1 78  ? -38.490 16.950  -7.358  1.00 51.58  ? 77  GLN A O   1 
ATOM   578  C CB  . GLN A 1 78  ? -39.260 14.933  -9.725  1.00 50.47  ? 77  GLN A CB  1 
ATOM   579  C CG  . GLN A 1 78  ? -40.041 14.389  -10.914 1.00 54.90  ? 77  GLN A CG  1 
ATOM   580  C CD  . GLN A 1 78  ? -39.175 13.582  -11.855 1.00 56.79  ? 77  GLN A CD  1 
ATOM   581  O OE1 . GLN A 1 78  ? -37.977 13.416  -11.625 1.00 58.83  ? 77  GLN A OE1 1 
ATOM   582  N NE2 . GLN A 1 78  ? -39.773 13.077  -12.928 1.00 61.34  ? 77  GLN A NE2 1 
ATOM   583  N N   . VAL A 1 79  ? -39.847 15.338  -6.548  1.00 47.58  ? 78  VAL A N   1 
ATOM   584  C CA  . VAL A 1 79  ? -39.279 15.314  -5.205  1.00 44.72  ? 78  VAL A CA  1 
ATOM   585  C C   . VAL A 1 79  ? -38.872 13.881  -4.899  1.00 46.72  ? 78  VAL A C   1 
ATOM   586  O O   . VAL A 1 79  ? -39.645 12.948  -5.140  1.00 44.93  ? 78  VAL A O   1 
ATOM   587  C CB  . VAL A 1 79  ? -40.273 15.837  -4.150  1.00 45.62  ? 78  VAL A CB  1 
ATOM   588  C CG1 . VAL A 1 79  ? -39.661 15.773  -2.761  1.00 46.44  ? 78  VAL A CG1 1 
ATOM   589  C CG2 . VAL A 1 79  ? -40.703 17.263  -4.484  1.00 47.37  ? 78  VAL A CG2 1 
ATOM   590  N N   . PHE A 1 80  ? -37.665 13.701  -4.368  1.00 46.32  ? 79  PHE A N   1 
ATOM   591  C CA  . PHE A 1 80  ? -37.088 12.375  -4.195  1.00 45.29  ? 79  PHE A CA  1 
ATOM   592  C C   . PHE A 1 80  ? -36.898 12.059  -2.719  1.00 48.42  ? 79  PHE A C   1 
ATOM   593  O O   . PHE A 1 80  ? -36.367 12.880  -1.964  1.00 53.46  ? 79  PHE A O   1 
ATOM   594  C CB  . PHE A 1 80  ? -35.755 12.260  -4.937  1.00 47.29  ? 79  PHE A CB  1 
ATOM   595  C CG  . PHE A 1 80  ? -35.831 12.699  -6.370  1.00 43.68  ? 79  PHE A CG  1 
ATOM   596  C CD1 . PHE A 1 80  ? -36.421 11.889  -7.327  1.00 46.17  ? 79  PHE A CD1 1 
ATOM   597  C CD2 . PHE A 1 80  ? -35.320 13.927  -6.758  1.00 58.74  ? 79  PHE A CD2 1 
ATOM   598  C CE1 . PHE A 1 80  ? -36.498 12.293  -8.646  1.00 50.75  ? 79  PHE A CE1 1 
ATOM   599  C CE2 . PHE A 1 80  ? -35.393 14.337  -8.076  1.00 57.40  ? 79  PHE A CE2 1 
ATOM   600  C CZ  . PHE A 1 80  ? -35.982 13.519  -9.021  1.00 60.79  ? 79  PHE A CZ  1 
ATOM   601  N N   . LEU A 1 81  ? -37.335 10.867  -2.321  1.00 53.28  ? 80  LEU A N   1 
ATOM   602  C CA  . LEU A 1 81  ? -37.090 10.319  -0.995  1.00 49.63  ? 80  LEU A CA  1 
ATOM   603  C C   . LEU A 1 81  ? -36.087 9.180   -1.105  1.00 51.35  ? 80  LEU A C   1 
ATOM   604  O O   . LEU A 1 81  ? -36.151 8.374   -2.038  1.00 50.19  ? 80  LEU A O   1 
ATOM   605  C CB  . LEU A 1 81  ? -38.384 9.807   -0.357  1.00 51.25  ? 80  LEU A CB  1 
ATOM   606  C CG  . LEU A 1 81  ? -38.247 9.135   1.013   1.00 56.54  ? 80  LEU A CG  1 
ATOM   607  C CD1 . LEU A 1 81  ? -37.829 10.147  2.069   1.00 69.05  ? 80  LEU A CD1 1 
ATOM   608  C CD2 . LEU A 1 81  ? -39.539 8.434   1.413   1.00 53.22  ? 80  LEU A CD2 1 
ATOM   609  N N   . GLU A 1 82  ? -35.162 9.115   -0.150  1.00 59.86  ? 81  GLU A N   1 
ATOM   610  C CA  . GLU A 1 82  ? -34.139 8.075   -0.135  1.00 63.18  ? 81  GLU A CA  1 
ATOM   611  C C   . GLU A 1 82  ? -33.916 7.612   1.296   1.00 57.87  ? 81  GLU A C   1 
ATOM   612  O O   . GLU A 1 82  ? -33.505 8.407   2.148   1.00 59.64  ? 81  GLU A O   1 
ATOM   613  C CB  . GLU A 1 82  ? -32.830 8.579   -0.751  1.00 59.75  ? 81  GLU A CB  1 
ATOM   614  C CG  . GLU A 1 82  ? -31.705 7.561   -0.727  1.00 68.25  ? 81  GLU A CG  1 
ATOM   615  C CD  . GLU A 1 82  ? -30.534 7.978   -1.592  1.00 84.29  ? 81  GLU A CD  1 
ATOM   616  O OE1 . GLU A 1 82  ? -30.756 8.711   -2.580  1.00 71.76  ? 81  GLU A OE1 1 
ATOM   617  O OE2 . GLU A 1 82  ? -29.391 7.579   -1.283  1.00 74.31  ? 81  GLU A OE2 1 
ATOM   618  N N   . MET A 1 83  ? -34.181 6.334   1.559   1.00 50.81  ? 82  MET A N   1 
ATOM   619  C CA  . MET A 1 83  ? -34.019 5.750   2.882   1.00 55.38  ? 82  MET A CA  1 
ATOM   620  C C   . MET A 1 83  ? -32.998 4.621   2.828   1.00 53.96  ? 82  MET A C   1 
ATOM   621  O O   . MET A 1 83  ? -32.947 3.865   1.854   1.00 57.37  ? 82  MET A O   1 
ATOM   622  C CB  . MET A 1 83  ? -35.358 5.233   3.426   1.00 50.92  ? 82  MET A CB  1 
ATOM   623  C CG  . MET A 1 83  ? -35.367 4.974   4.927   1.00 63.00  ? 82  MET A CG  1 
ATOM   624  S SD  . MET A 1 83  ? -36.929 4.289   5.518   1.00 69.76  ? 82  MET A SD  1 
ATOM   625  C CE  . MET A 1 83  ? -38.078 5.579   5.050   1.00 60.89  ? 82  MET A CE  1 
ATOM   626  N N   . ASP A 1 84  ? -32.182 4.514   3.875   1.00 59.30  ? 83  ASP A N   1 
ATOM   627  C CA  . ASP A 1 84  ? -31.106 3.536   3.950   1.00 57.81  ? 83  ASP A CA  1 
ATOM   628  C C   . ASP A 1 84  ? -31.416 2.466   4.990   1.00 65.59  ? 83  ASP A C   1 
ATOM   629  O O   . ASP A 1 84  ? -32.231 2.663   5.895   1.00 59.53  ? 83  ASP A O   1 
ATOM   630  C CB  . ASP A 1 84  ? -29.772 4.208   4.296   1.00 62.44  ? 83  ASP A CB  1 
ATOM   631  C CG  . ASP A 1 84  ? -29.206 5.015   3.144   1.00 66.90  ? 83  ASP A CG  1 
ATOM   632  O OD1 . ASP A 1 84  ? -29.612 4.769   1.989   1.00 67.36  ? 83  ASP A OD1 1 
ATOM   633  O OD2 . ASP A 1 84  ? -28.348 5.889   3.392   1.00 71.62  ? 83  ASP A OD2 1 
ATOM   634  N N   . SER A 1 85  ? -30.743 1.323   4.841   1.00 63.62  ? 84  SER A N   1 
ATOM   635  C CA  . SER A 1 85  ? -30.794 0.226   5.810   1.00 64.25  ? 84  SER A CA  1 
ATOM   636  C C   . SER A 1 85  ? -32.233 -0.195  6.102   1.00 59.62  ? 84  SER A C   1 
ATOM   637  O O   . SER A 1 85  ? -32.650 -0.320  7.256   1.00 60.39  ? 84  SER A O   1 
ATOM   638  C CB  . SER A 1 85  ? -30.061 0.607   7.098   1.00 67.69  ? 84  SER A CB  1 
ATOM   639  O OG  . SER A 1 85  ? -28.730 1.009   6.825   1.00 78.89  ? 84  SER A OG  1 
ATOM   640  N N   . LEU A 1 86  ? -32.996 -0.420  5.034   1.00 60.16  ? 85  LEU A N   1 
ATOM   641  C CA  . LEU A 1 86  ? -34.402 -0.777  5.177   1.00 59.11  ? 85  LEU A CA  1 
ATOM   642  C C   . LEU A 1 86  ? -34.558 -2.154  5.804   1.00 62.49  ? 85  LEU A C   1 
ATOM   643  O O   . LEU A 1 86  ? -33.794 -3.078  5.514   1.00 62.45  ? 85  LEU A O   1 
ATOM   644  C CB  . LEU A 1 86  ? -35.102 -0.753  3.820   1.00 65.52  ? 85  LEU A CB  1 
ATOM   645  C CG  . LEU A 1 86  ? -35.921 0.495   3.491   1.00 61.56  ? 85  LEU A CG  1 
ATOM   646  C CD1 . LEU A 1 86  ? -35.007 1.648   3.110   1.00 63.54  ? 85  LEU A CD1 1 
ATOM   647  C CD2 . LEU A 1 86  ? -36.930 0.195   2.393   1.00 57.07  ? 85  LEU A CD2 1 
ATOM   648  N N   . GLN A 1 87  ? -35.565 -2.289  6.666   1.00 59.51  ? 86  GLN A N   1 
ATOM   649  C CA  . GLN A 1 87  ? -35.883 -3.579  7.265   1.00 62.68  ? 86  GLN A CA  1 
ATOM   650  C C   . GLN A 1 87  ? -37.375 -3.869  7.140   1.00 62.50  ? 86  GLN A C   1 
ATOM   651  O O   . GLN A 1 87  ? -38.101 -3.130  6.466   1.00 54.74  ? 86  GLN A O   1 
ATOM   652  C CB  . GLN A 1 87  ? -35.447 -3.619  8.732   1.00 64.28  ? 86  GLN A CB  1 
ATOM   653  C CG  . GLN A 1 87  ? -34.010 -3.159  8.986   1.00 57.33  ? 86  GLN A CG  1 
ATOM   654  C CD  . GLN A 1 87  ? -32.968 -3.981  8.239   1.00 67.44  ? 86  GLN A CD  1 
ATOM   655  O OE1 . GLN A 1 87  ? -33.221 -5.118  7.838   1.00 66.67  ? 86  GLN A OE1 1 
ATOM   656  N NE2 . GLN A 1 87  ? -31.787 -3.402  8.048   1.00 72.61  ? 86  GLN A NE2 1 
ATOM   657  N N   . THR A 1 88  ? -37.836 -4.943  7.785   1.00 58.91  ? 87  THR A N   1 
ATOM   658  C CA  . THR A 1 88  ? -39.242 -5.327  7.688   1.00 60.72  ? 87  THR A CA  1 
ATOM   659  C C   . THR A 1 88  ? -40.164 -4.263  8.275   1.00 61.11  ? 87  THR A C   1 
ATOM   660  O O   . THR A 1 88  ? -41.266 -4.044  7.758   1.00 61.97  ? 87  THR A O   1 
ATOM   661  C CB  . THR A 1 88  ? -39.456 -6.678  8.380   1.00 58.09  ? 87  THR A CB  1 
ATOM   662  O OG1 . THR A 1 88  ? -38.905 -7.722  7.566   1.00 67.50  ? 87  THR A OG1 1 
ATOM   663  C CG2 . THR A 1 88  ? -40.935 -6.959  8.620   1.00 57.97  ? 87  THR A CG2 1 
ATOM   664  N N   . ASP A 1 89  ? -39.721 -3.571  9.331   1.00 55.12  ? 88  ASP A N   1 
ATOM   665  C CA  . ASP A 1 89  ? -40.566 -2.580  9.994   1.00 56.68  ? 88  ASP A CA  1 
ATOM   666  C C   . ASP A 1 89  ? -40.999 -1.467  9.048   1.00 52.84  ? 88  ASP A C   1 
ATOM   667  O O   . ASP A 1 89  ? -42.040 -0.838  9.265   1.00 52.98  ? 88  ASP A O   1 
ATOM   668  C CB  . ASP A 1 89  ? -39.830 -1.985  11.194  1.00 64.42  ? 88  ASP A CB  1 
ATOM   669  C CG  . ASP A 1 89  ? -40.468 -2.361  12.515  1.00 69.78  ? 88  ASP A CG  1 
ATOM   670  O OD1 . ASP A 1 89  ? -41.426 -3.162  12.509  1.00 70.89  ? 88  ASP A OD1 1 
ATOM   671  O OD2 . ASP A 1 89  ? -40.016 -1.848  13.559  1.00 71.70  ? 88  ASP A OD2 1 
ATOM   672  N N   . ASP A 1 90  ? -40.222 -1.211  8.000   1.00 54.33  ? 89  ASP A N   1 
ATOM   673  C CA  . ASP A 1 90  ? -40.506 -0.127  7.071   1.00 54.74  ? 89  ASP A CA  1 
ATOM   674  C C   . ASP A 1 90  ? -41.508 -0.512  5.987   1.00 55.70  ? 89  ASP A C   1 
ATOM   675  O O   . ASP A 1 90  ? -41.727 0.278   5.061   1.00 51.42  ? 89  ASP A O   1 
ATOM   676  C CB  . ASP A 1 90  ? -39.201 0.363   6.439   1.00 49.76  ? 89  ASP A CB  1 
ATOM   677  C CG  . ASP A 1 90  ? -38.186 0.806   7.478   1.00 56.31  ? 89  ASP A CG  1 
ATOM   678  O OD1 . ASP A 1 90  ? -38.600 1.398   8.498   1.00 54.87  ? 89  ASP A OD1 1 
ATOM   679  O OD2 . ASP A 1 90  ? -36.979 0.554   7.282   1.00 55.56  ? 89  ASP A OD2 1 
ATOM   680  N N   . THR A 1 91  ? -42.116 -1.693  6.074   1.00 51.35  ? 90  THR A N   1 
ATOM   681  C CA  . THR A 1 91  ? -43.185 -2.054  5.151   1.00 53.26  ? 90  THR A CA  1 
ATOM   682  C C   . THR A 1 91  ? -44.388 -1.153  5.400   1.00 52.41  ? 90  THR A C   1 
ATOM   683  O O   . THR A 1 91  ? -45.006 -1.212  6.470   1.00 50.06  ? 90  THR A O   1 
ATOM   684  C CB  . THR A 1 91  ? -43.571 -3.522  5.322   1.00 53.27  ? 90  THR A CB  1 
ATOM   685  O OG1 . THR A 1 91  ? -42.504 -4.356  4.857   1.00 51.87  ? 90  THR A OG1 1 
ATOM   686  C CG2 . THR A 1 91  ? -44.836 -3.838  4.532   1.00 54.26  ? 90  THR A CG2 1 
ATOM   687  N N   . ALA A 1 92  ? -44.720 -0.319  4.418   1.00 45.74  ? 91  ALA A N   1 
ATOM   688  C CA  . ALA A 1 92  ? -45.792 0.652   4.589   1.00 49.04  ? 91  ALA A CA  1 
ATOM   689  C C   . ALA A 1 92  ? -46.185 1.207   3.229   1.00 46.64  ? 91  ALA A C   1 
ATOM   690  O O   . ALA A 1 92  ? -45.488 1.017   2.229   1.00 46.25  ? 91  ALA A O   1 
ATOM   691  C CB  . ALA A 1 92  ? -45.373 1.785   5.530   1.00 43.30  ? 91  ALA A CB  1 
ATOM   692  N N   . MET A 1 93  ? -47.321 1.900   3.210   1.00 44.33  ? 92  MET A N   1 
ATOM   693  C CA  . MET A 1 93  ? -47.731 2.708   2.071   1.00 41.35  ? 92  MET A CA  1 
ATOM   694  C C   . MET A 1 93  ? -47.119 4.095   2.231   1.00 48.14  ? 92  MET A C   1 
ATOM   695  O O   . MET A 1 93  ? -47.363 4.769   3.236   1.00 43.09  ? 92  MET A O   1 
ATOM   696  C CB  . MET A 1 93  ? -49.254 2.788   1.991   1.00 48.63  ? 92  MET A CB  1 
ATOM   697  C CG  . MET A 1 93  ? -49.765 3.760   0.951   1.00 48.56  ? 92  MET A CG  1 
ATOM   698  S SD  . MET A 1 93  ? -49.696 3.099   -0.717  1.00 55.03  ? 92  MET A SD  1 
ATOM   699  C CE  . MET A 1 93  ? -51.252 2.219   -0.789  1.00 55.02  ? 92  MET A CE  1 
ATOM   700  N N   . TYR A 1 94  ? -46.322 4.515   1.253   1.00 41.88  ? 93  TYR A N   1 
ATOM   701  C CA  . TYR A 1 94  ? -45.583 5.770   1.333   1.00 42.46  ? 93  TYR A CA  1 
ATOM   702  C C   . TYR A 1 94  ? -46.268 6.839   0.494   1.00 42.33  ? 93  TYR A C   1 
ATOM   703  O O   . TYR A 1 94  ? -46.541 6.627   -0.691  1.00 41.45  ? 93  TYR A O   1 
ATOM   704  C CB  . TYR A 1 94  ? -44.137 5.579   0.874   1.00 45.57  ? 93  TYR A CB  1 
ATOM   705  C CG  . TYR A 1 94  ? -43.265 4.892   1.900   1.00 37.35  ? 93  TYR A CG  1 
ATOM   706  C CD1 . TYR A 1 94  ? -43.405 3.536   2.162   1.00 38.70  ? 93  TYR A CD1 1 
ATOM   707  C CD2 . TYR A 1 94  ? -42.302 5.601   2.609   1.00 44.21  ? 93  TYR A CD2 1 
ATOM   708  C CE1 . TYR A 1 94  ? -42.614 2.905   3.101   1.00 46.14  ? 93  TYR A CE1 1 
ATOM   709  C CE2 . TYR A 1 94  ? -41.505 4.979   3.549   1.00 42.25  ? 93  TYR A CE2 1 
ATOM   710  C CZ  . TYR A 1 94  ? -41.665 3.630   3.791   1.00 45.63  ? 93  TYR A CZ  1 
ATOM   711  O OH  . TYR A 1 94  ? -40.875 3.000   4.728   1.00 42.66  ? 93  TYR A OH  1 
ATOM   712  N N   . TYR A 1 95  ? -46.540 7.985   1.115   1.00 37.36  ? 94  TYR A N   1 
ATOM   713  C CA  . TYR A 1 95  ? -47.182 9.109   0.455   1.00 38.69  ? 94  TYR A CA  1 
ATOM   714  C C   . TYR A 1 95  ? -46.238 10.299  0.397   1.00 37.51  ? 94  TYR A C   1 
ATOM   715  O O   . TYR A 1 95  ? -45.407 10.502  1.287   1.00 37.14  ? 94  TYR A O   1 
ATOM   716  C CB  . TYR A 1 95  ? -48.457 9.553   1.184   1.00 40.57  ? 94  TYR A CB  1 
ATOM   717  C CG  . TYR A 1 95  ? -49.552 8.521   1.282   1.00 35.02  ? 94  TYR A CG  1 
ATOM   718  C CD1 . TYR A 1 95  ? -50.523 8.417   0.296   1.00 41.10  ? 94  TYR A CD1 1 
ATOM   719  C CD2 . TYR A 1 95  ? -49.634 7.673   2.376   1.00 44.03  ? 94  TYR A CD2 1 
ATOM   720  C CE1 . TYR A 1 95  ? -51.534 7.484   0.388   1.00 40.16  ? 94  TYR A CE1 1 
ATOM   721  C CE2 . TYR A 1 95  ? -50.642 6.737   2.478   1.00 40.23  ? 94  TYR A CE2 1 
ATOM   722  C CZ  . TYR A 1 95  ? -51.591 6.647   1.482   1.00 40.92  ? 94  TYR A CZ  1 
ATOM   723  O OH  . TYR A 1 95  ? -52.599 5.714   1.579   1.00 47.01  ? 94  TYR A OH  1 
ATOM   724  N N   . CYS A 1 96  ? -46.385 11.091  -0.658  1.00 43.03  ? 95  CYS A N   1 
ATOM   725  C CA  . CYS A 1 96  ? -45.909 12.463  -0.671  1.00 39.18  ? 95  CYS A CA  1 
ATOM   726  C C   . CYS A 1 96  ? -47.115 13.389  -0.639  1.00 40.71  ? 95  CYS A C   1 
ATOM   727  O O   . CYS A 1 96  ? -48.128 13.128  -1.298  1.00 40.72  ? 95  CYS A O   1 
ATOM   728  C CB  . CYS A 1 96  ? -45.030 12.756  -1.891  1.00 42.63  ? 95  CYS A CB  1 
ATOM   729  S SG  . CYS A 1 96  ? -45.758 12.418  -3.509  1.00 42.58  ? 95  CYS A SG  1 
ATOM   730  N N   . ALA A 1 97  ? -47.016 14.452  0.150   1.00 35.71  ? 96  ALA A N   1 
ATOM   731  C CA  . ALA A 1 97  ? -48.103 15.402  0.304   1.00 34.77  ? 96  ALA A CA  1 
ATOM   732  C C   . ALA A 1 97  ? -47.578 16.814  0.106   1.00 38.30  ? 96  ALA A C   1 
ATOM   733  O O   . ALA A 1 97  ? -46.408 17.104  0.371   1.00 38.67  ? 96  ALA A O   1 
ATOM   734  C CB  . ALA A 1 97  ? -48.771 15.275  1.675   1.00 33.76  ? 96  ALA A CB  1 
ATOM   735  N N   . LYS A 1 98  ? -48.460 17.687  -0.363  1.00 40.28  ? 97  LYS A N   1 
ATOM   736  C CA  . LYS A 1 98  ? -48.120 19.056  -0.722  1.00 40.77  ? 97  LYS A CA  1 
ATOM   737  C C   . LYS A 1 98  ? -48.729 20.014  0.292   1.00 37.78  ? 97  LYS A C   1 
ATOM   738  O O   . LYS A 1 98  ? -49.915 19.903  0.623   1.00 41.08  ? 97  LYS A O   1 
ATOM   739  C CB  . LYS A 1 98  ? -48.615 19.371  -2.136  1.00 45.49  ? 97  LYS A CB  1 
ATOM   740  C CG  . LYS A 1 98  ? -48.597 20.840  -2.513  1.00 47.49  ? 97  LYS A CG  1 
ATOM   741  C CD  . LYS A 1 98  ? -50.006 21.409  -2.537  1.00 37.61  ? 97  LYS A CD  1 
ATOM   742  C CE  . LYS A 1 98  ? -50.007 22.857  -2.987  1.00 43.61  ? 97  LYS A CE  1 
ATOM   743  N NZ  . LYS A 1 98  ? -51.299 23.521  -2.671  1.00 36.10  ? 97  LYS A NZ  1 
ATOM   744  N N   . HIS A 1 99  ? -47.916 20.949  0.777   1.00 40.86  ? 98  HIS A N   1 
ATOM   745  C CA  . HIS A 1 99  ? -48.348 21.940  1.748   1.00 45.28  ? 98  HIS A CA  1 
ATOM   746  C C   . HIS A 1 99  ? -48.853 23.198  1.054   1.00 45.98  ? 98  HIS A C   1 
ATOM   747  O O   . HIS A 1 99  ? -48.684 23.393  -0.150  1.00 43.43  ? 98  HIS A O   1 
ATOM   748  C CB  . HIS A 1 99  ? -47.204 22.313  2.688   1.00 42.50  ? 98  HIS A CB  1 
ATOM   749  C CG  . HIS A 1 99  ? -46.723 21.180  3.533   1.00 34.59  ? 98  HIS A CG  1 
ATOM   750  N ND1 . HIS A 1 99  ? -47.062 21.048  4.862   1.00 39.05  ? 98  HIS A ND1 1 
ATOM   751  C CD2 . HIS A 1 99  ? -45.925 20.126  3.241   1.00 38.26  ? 98  HIS A CD2 1 
ATOM   752  C CE1 . HIS A 1 99  ? -46.495 19.962  5.353   1.00 36.52  ? 98  HIS A CE1 1 
ATOM   753  N NE2 . HIS A 1 99  ? -45.800 19.384  4.390   1.00 41.28  ? 98  HIS A NE2 1 
ATOM   754  N N   . ASP A 1 100 ? -49.479 24.068  1.843   1.00 48.23  ? 99  ASP A N   1 
ATOM   755  C CA  . ASP A 1 100 ? -49.790 25.420  1.391   1.00 43.06  ? 99  ASP A CA  1 
ATOM   756  C C   . ASP A 1 100 ? -48.631 26.314  1.814   1.00 45.12  ? 99  ASP A C   1 
ATOM   757  O O   . ASP A 1 100 ? -48.670 26.995  2.839   1.00 44.68  ? 99  ASP A O   1 
ATOM   758  C CB  . ASP A 1 100 ? -51.104 25.905  1.981   1.00 44.91  ? 99  ASP A CB  1 
ATOM   759  C CG  . ASP A 1 100 ? -51.445 27.323  1.560   1.00 46.67  ? 99  ASP A CG  1 
ATOM   760  O OD1 . ASP A 1 100 ? -50.872 27.813  0.562   1.00 46.80  ? 99  ASP A OD1 1 
ATOM   761  O OD2 . ASP A 1 100 ? -52.298 27.948  2.225   1.00 50.04  ? 99  ASP A OD2 1 
ATOM   762  N N   . GLY A 1 101 ? -47.566 26.279  1.016   1.00 50.33  ? 100 GLY A N   1 
ATOM   763  C CA  . GLY A 1 101 ? -46.373 27.058  1.291   1.00 49.70  ? 100 GLY A CA  1 
ATOM   764  C C   . GLY A 1 101 ? -45.567 26.516  2.450   1.00 44.27  ? 100 GLY A C   1 
ATOM   765  O O   . GLY A 1 101 ? -44.467 25.981  2.263   1.00 49.43  ? 100 GLY A O   1 
ATOM   766  N N   . HIS A 1 102 ? -46.122 26.625  3.656   1.00 50.64  ? 101 HIS A N   1 
ATOM   767  C CA  . HIS A 1 102 ? -45.391 26.244  4.856   1.00 42.07  ? 101 HIS A CA  1 
ATOM   768  C C   . HIS A 1 102 ? -46.325 25.949  6.027   1.00 53.70  ? 101 HIS A C   1 
ATOM   769  O O   . HIS A 1 102 ? -45.852 25.648  7.125   1.00 48.17  ? 101 HIS A O   1 
ATOM   770  C CB  . HIS A 1 102 ? -44.409 27.356  5.242   1.00 47.81  ? 101 HIS A CB  1 
ATOM   771  C CG  . HIS A 1 102 ? -43.193 26.879  5.980   1.00 53.18  ? 101 HIS A CG  1 
ATOM   772  N ND1 . HIS A 1 102 ? -43.240 26.401  7.272   1.00 49.44  ? 101 HIS A ND1 1 
ATOM   773  C CD2 . HIS A 1 102 ? -41.889 26.839  5.614   1.00 54.74  ? 101 HIS A CD2 1 
ATOM   774  C CE1 . HIS A 1 102 ? -42.021 26.071  7.664   1.00 56.14  ? 101 HIS A CE1 1 
ATOM   775  N NE2 . HIS A 1 102 ? -41.183 26.328  6.676   1.00 53.36  ? 101 HIS A NE2 1 
ATOM   776  N N   . GLU A 1 103 ? -47.642 26.015  5.824   1.00 65.70  ? 102 GLU A N   1 
ATOM   777  C CA  . GLU A 1 103 ? -48.559 25.910  6.958   1.00 56.88  ? 102 GLU A CA  1 
ATOM   778  C C   . GLU A 1 103 ? -49.227 24.545  7.092   1.00 60.80  ? 102 GLU A C   1 
ATOM   779  O O   . GLU A 1 103 ? -48.941 23.802  8.043   1.00 60.96  ? 102 GLU A O   1 
ATOM   780  C CB  . GLU A 1 103 ? -49.634 27.002  6.882   1.00 61.50  ? 102 GLU A CB  1 
ATOM   781  C CG  . GLU A 1 103 ? -49.201 28.319  7.523   1.00 67.25  ? 102 GLU A CG  1 
ATOM   782  C CD  . GLU A 1 103 ? -50.331 29.339  7.623   1.00 68.06  ? 102 GLU A CD  1 
ATOM   783  O OE1 . GLU A 1 103 ? -50.317 30.176  8.556   1.00 60.84  ? 102 GLU A OE1 1 
ATOM   784  O OE2 . GLU A 1 103 ? -51.236 29.308  6.764   1.00 65.34  ? 102 GLU A OE2 1 
ATOM   785  N N   . THR A 1 104 ? -50.131 24.232  6.158   1.00 40.82  ? 103 THR A N   1 
ATOM   786  C CA  . THR A 1 104 ? -50.994 23.061  6.241   1.00 42.98  ? 103 THR A CA  1 
ATOM   787  C C   . THR A 1 104 ? -50.747 22.113  5.077   1.00 41.71  ? 103 THR A C   1 
ATOM   788  O O   . THR A 1 104 ? -50.658 22.541  3.924   1.00 38.08  ? 103 THR A O   1 
ATOM   789  C CB  . THR A 1 104 ? -52.473 23.467  6.280   1.00 42.94  ? 103 THR A CB  1 
ATOM   790  O OG1 . THR A 1 104 ? -53.280 22.423  5.719   1.00 41.61  ? 103 THR A OG1 1 
ATOM   791  C CG2 . THR A 1 104 ? -52.694 24.752  5.492   1.00 38.57  ? 103 THR A CG2 1 
ATOM   792  N N   . MET A 1 105 ? -50.676 20.819  5.390   1.00 33.26  ? 104 MET A N   1 
ATOM   793  C CA  . MET A 1 105 ? -50.458 19.755  4.410   1.00 35.44  ? 104 MET A CA  1 
ATOM   794  C C   . MET A 1 105 ? -51.759 19.518  3.652   1.00 32.32  ? 104 MET A C   1 
ATOM   795  O O   . MET A 1 105 ? -52.681 18.878  4.159   1.00 33.37  ? 104 MET A O   1 
ATOM   796  C CB  . MET A 1 105 ? -49.978 18.492  5.117   1.00 29.53  ? 104 MET A CB  1 
ATOM   797  C CG  . MET A 1 105 ? -49.066 17.599  4.300   1.00 35.26  ? 104 MET A CG  1 
ATOM   798  S SD  . MET A 1 105 ? -48.198 16.388  5.319   1.00 42.00  ? 104 MET A SD  1 
ATOM   799  C CE  . MET A 1 105 ? -49.561 15.478  6.021   1.00 39.84  ? 104 MET A CE  1 
ATOM   800  N N   . ASP A 1 106 ? -51.823 20.015  2.415   1.00 38.50  ? 105 ASP A N   1 
ATOM   801  C CA  . ASP A 1 106 ? -53.091 20.090  1.685   1.00 38.49  ? 105 ASP A CA  1 
ATOM   802  C C   . ASP A 1 106 ? -53.443 18.782  0.988   1.00 40.71  ? 105 ASP A C   1 
ATOM   803  O O   . ASP A 1 106 ? -54.454 18.149  1.304   1.00 38.87  ? 105 ASP A O   1 
ATOM   804  C CB  . ASP A 1 106 ? -53.038 21.226  0.660   1.00 37.27  ? 105 ASP A CB  1 
ATOM   805  C CG  . ASP A 1 106 ? -53.312 22.573  1.270   1.00 46.48  ? 105 ASP A CG  1 
ATOM   806  O OD1 . ASP A 1 106 ? -54.005 22.621  2.306   1.00 41.18  ? 105 ASP A OD1 1 
ATOM   807  O OD2 . ASP A 1 106 ? -52.838 23.583  0.709   1.00 39.39  ? 105 ASP A OD2 1 
ATOM   808  N N   . TYR A 1 107 ? -52.640 18.384  0.007   1.00 35.42  ? 106 TYR A N   1 
ATOM   809  C CA  . TYR A 1 107 ? -53.041 17.366  -0.954  1.00 38.90  ? 106 TYR A CA  1 
ATOM   810  C C   . TYR A 1 107 ? -52.074 16.194  -0.936  1.00 39.43  ? 106 TYR A C   1 
ATOM   811  O O   . TYR A 1 107 ? -50.856 16.380  -1.017  1.00 37.99  ? 106 TYR A O   1 
ATOM   812  C CB  . TYR A 1 107 ? -53.142 17.965  -2.358  1.00 35.19  ? 106 TYR A CB  1 
ATOM   813  C CG  . TYR A 1 107 ? -54.291 18.934  -2.478  1.00 36.96  ? 106 TYR A CG  1 
ATOM   814  C CD1 . TYR A 1 107 ? -55.600 18.477  -2.524  1.00 46.13  ? 106 TYR A CD1 1 
ATOM   815  C CD2 . TYR A 1 107 ? -54.072 20.303  -2.524  1.00 40.15  ? 106 TYR A CD2 1 
ATOM   816  C CE1 . TYR A 1 107 ? -56.660 19.354  -2.621  1.00 40.31  ? 106 TYR A CE1 1 
ATOM   817  C CE2 . TYR A 1 107 ? -55.127 21.191  -2.622  1.00 39.46  ? 106 TYR A CE2 1 
ATOM   818  C CZ  . TYR A 1 107 ? -56.418 20.710  -2.671  1.00 40.71  ? 106 TYR A CZ  1 
ATOM   819  O OH  . TYR A 1 107 ? -57.474 21.587  -2.770  1.00 47.35  ? 106 TYR A OH  1 
ATOM   820  N N   . TRP A 1 108 ? -52.631 14.992  -0.848  1.00 35.00  ? 107 TRP A N   1 
ATOM   821  C CA  . TRP A 1 108 ? -51.862 13.762  -0.808  1.00 34.27  ? 107 TRP A CA  1 
ATOM   822  C C   . TRP A 1 108 ? -51.768 13.142  -2.197  1.00 36.50  ? 107 TRP A C   1 
ATOM   823  O O   . TRP A 1 108 ? -52.572 13.424  -3.090  1.00 37.91  ? 107 TRP A O   1 
ATOM   824  C CB  . TRP A 1 108 ? -52.500 12.763  0.157   1.00 36.56  ? 107 TRP A CB  1 
ATOM   825  C CG  . TRP A 1 108 ? -52.570 13.228  1.576   1.00 34.92  ? 107 TRP A CG  1 
ATOM   826  C CD1 . TRP A 1 108 ? -53.274 14.291  2.059   1.00 44.23  ? 107 TRP A CD1 1 
ATOM   827  C CD2 . TRP A 1 108 ? -51.929 12.625  2.704   1.00 35.35  ? 107 TRP A CD2 1 
ATOM   828  N NE1 . TRP A 1 108 ? -53.102 14.395  3.418   1.00 36.29  ? 107 TRP A NE1 1 
ATOM   829  C CE2 . TRP A 1 108 ? -52.281 13.383  3.838   1.00 39.91  ? 107 TRP A CE2 1 
ATOM   830  C CE3 . TRP A 1 108 ? -51.088 11.519  2.864   1.00 34.57  ? 107 TRP A CE3 1 
ATOM   831  C CZ2 . TRP A 1 108 ? -51.822 13.069  5.114   1.00 41.97  ? 107 TRP A CZ2 1 
ATOM   832  C CZ3 . TRP A 1 108 ? -50.634 11.211  4.129   1.00 33.45  ? 107 TRP A CZ3 1 
ATOM   833  C CH2 . TRP A 1 108 ? -50.999 11.984  5.239   1.00 37.58  ? 107 TRP A CH2 1 
ATOM   834  N N   . GLY A 1 109 ? -50.769 12.279  -2.369  1.00 38.39  ? 108 GLY A N   1 
ATOM   835  C CA  . GLY A 1 109 ? -50.630 11.516  -3.589  1.00 39.44  ? 108 GLY A CA  1 
ATOM   836  C C   . GLY A 1 109 ? -51.392 10.205  -3.525  1.00 43.66  ? 108 GLY A C   1 
ATOM   837  O O   . GLY A 1 109 ? -52.021 9.861   -2.525  1.00 43.87  ? 108 GLY A O   1 
ATOM   838  N N   . GLN A 1 110 ? -51.329 9.466   -4.635  1.00 46.75  ? 109 GLN A N   1 
ATOM   839  C CA  . GLN A 1 110 ? -51.942 8.143   -4.681  1.00 46.60  ? 109 GLN A CA  1 
ATOM   840  C C   . GLN A 1 110 ? -51.346 7.212   -3.634  1.00 47.25  ? 109 GLN A C   1 
ATOM   841  O O   . GLN A 1 110 ? -52.052 6.354   -3.090  1.00 46.21  ? 109 GLN A O   1 
ATOM   842  C CB  . GLN A 1 110 ? -51.771 7.540   -6.076  1.00 53.70  ? 109 GLN A CB  1 
ATOM   843  C CG  . GLN A 1 110 ? -52.949 7.761   -7.005  1.00 72.33  ? 109 GLN A CG  1 
ATOM   844  C CD  . GLN A 1 110 ? -53.983 6.659   -6.896  1.00 97.48  ? 109 GLN A CD  1 
ATOM   845  O OE1 . GLN A 1 110 ? -53.691 5.489   -7.153  1.00 71.54  ? 109 GLN A OE1 1 
ATOM   846  N NE2 . GLN A 1 110 ? -55.199 7.024   -6.508  1.00 97.16  ? 109 GLN A NE2 1 
ATOM   847  N N   . GLY A 1 111 ? -50.061 7.374   -3.333  1.00 41.39  ? 110 GLY A N   1 
ATOM   848  C CA  . GLY A 1 111 ? -49.362 6.466   -2.450  1.00 40.00  ? 110 GLY A CA  1 
ATOM   849  C C   . GLY A 1 111 ? -48.803 5.280   -3.206  1.00 41.34  ? 110 GLY A C   1 
ATOM   850  O O   . GLY A 1 111 ? -49.427 4.793   -4.154  1.00 44.85  ? 110 GLY A O   1 
ATOM   851  N N   . THR A 1 112 ? -47.623 4.811   -2.810  1.00 41.53  ? 111 THR A N   1 
ATOM   852  C CA  . THR A 1 112 ? -47.025 3.620   -3.395  1.00 43.92  ? 111 THR A CA  1 
ATOM   853  C C   . THR A 1 112 ? -46.739 2.628   -2.278  1.00 47.22  ? 111 THR A C   1 
ATOM   854  O O   . THR A 1 112 ? -46.199 3.002   -1.230  1.00 45.44  ? 111 THR A O   1 
ATOM   855  C CB  . THR A 1 112 ? -45.748 3.956   -4.189  1.00 47.75  ? 111 THR A CB  1 
ATOM   856  O OG1 . THR A 1 112 ? -45.187 2.757   -4.740  1.00 44.68  ? 111 THR A OG1 1 
ATOM   857  C CG2 . THR A 1 112 ? -44.709 4.649   -3.313  1.00 44.02  ? 111 THR A CG2 1 
ATOM   858  N N   . SER A 1 113 ? -47.131 1.376   -2.485  1.00 49.10  ? 112 SER A N   1 
ATOM   859  C CA  . SER A 1 113 ? -47.006 0.349   -1.461  1.00 46.98  ? 112 SER A CA  1 
ATOM   860  C C   . SER A 1 113 ? -45.616 -0.270  -1.534  1.00 47.79  ? 112 SER A C   1 
ATOM   861  O O   . SER A 1 113 ? -45.216 -0.789  -2.582  1.00 49.69  ? 112 SER A O   1 
ATOM   862  C CB  . SER A 1 113 ? -48.085 -0.719  -1.631  1.00 52.26  ? 112 SER A CB  1 
ATOM   863  O OG  . SER A 1 113 ? -48.090 -1.624  -0.540  1.00 59.40  ? 112 SER A OG  1 
ATOM   864  N N   . VAL A 1 114 ? -44.885 -0.208  -0.426  1.00 50.00  ? 113 VAL A N   1 
ATOM   865  C CA  . VAL A 1 114 ? -43.541 -0.760  -0.319  1.00 49.30  ? 113 VAL A CA  1 
ATOM   866  C C   . VAL A 1 114 ? -43.595 -1.928  0.653   1.00 53.32  ? 113 VAL A C   1 
ATOM   867  O O   . VAL A 1 114 ? -43.966 -1.756  1.820   1.00 52.39  ? 113 VAL A O   1 
ATOM   868  C CB  . VAL A 1 114 ? -42.528 0.299   0.145   1.00 53.22  ? 113 VAL A CB  1 
ATOM   869  C CG1 . VAL A 1 114 ? -41.231 -0.361  0.586   1.00 51.02  ? 113 VAL A CG1 1 
ATOM   870  C CG2 . VAL A 1 114 ? -42.265 1.305   -0.966  1.00 47.72  ? 113 VAL A CG2 1 
ATOM   871  N N   . THR A 1 115 ? -43.235 -3.114  0.171   1.00 55.71  ? 114 THR A N   1 
ATOM   872  C CA  . THR A 1 115 ? -43.186 -4.322  0.981   1.00 53.07  ? 114 THR A CA  1 
ATOM   873  C C   . THR A 1 115 ? -41.738 -4.769  1.111   1.00 58.02  ? 114 THR A C   1 
ATOM   874  O O   . THR A 1 115 ? -41.020 -4.856  0.109   1.00 55.03  ? 114 THR A O   1 
ATOM   875  C CB  . THR A 1 115 ? -44.033 -5.437  0.360   1.00 54.81  ? 114 THR A CB  1 
ATOM   876  O OG1 . THR A 1 115 ? -45.387 -4.987  0.219   1.00 56.10  ? 114 THR A OG1 1 
ATOM   877  C CG2 . THR A 1 115 ? -44.008 -6.681  1.236   1.00 51.62  ? 114 THR A CG2 1 
ATOM   878  N N   . VAL A 1 116 ? -41.311 -5.043  2.341   1.00 55.25  ? 115 VAL A N   1 
ATOM   879  C CA  . VAL A 1 116 ? -39.948 -5.473  2.629   1.00 55.55  ? 115 VAL A CA  1 
ATOM   880  C C   . VAL A 1 116 ? -40.009 -6.905  3.144   1.00 57.32  ? 115 VAL A C   1 
ATOM   881  O O   . VAL A 1 116 ? -40.574 -7.169  4.213   1.00 57.11  ? 115 VAL A O   1 
ATOM   882  C CB  . VAL A 1 116 ? -39.257 -4.548  3.641   1.00 57.72  ? 115 VAL A CB  1 
ATOM   883  C CG1 . VAL A 1 116 ? -37.807 -4.960  3.828   1.00 58.85  ? 115 VAL A CG1 1 
ATOM   884  C CG2 . VAL A 1 116 ? -39.353 -3.099  3.186   1.00 54.96  ? 115 VAL A CG2 1 
ATOM   885  N N   . SER A 1 117 ? -39.433 -7.831  2.379   1.00 73.91  ? 116 SER A N   1 
ATOM   886  C CA  . SER A 1 117 ? -39.325 -9.228  2.777   1.00 73.91  ? 116 SER A CA  1 
ATOM   887  C C   . SER A 1 117 ? -38.143 -9.848  2.047   1.00 73.91  ? 116 SER A C   1 
ATOM   888  O O   . SER A 1 117 ? -37.921 -9.569  0.865   1.00 73.91  ? 116 SER A O   1 
ATOM   889  C CB  . SER A 1 117 ? -40.611 -10.007 2.473   1.00 73.91  ? 116 SER A CB  1 
ATOM   890  O OG  . SER A 1 117 ? -40.949 -9.926  1.100   1.00 73.91  ? 116 SER A OG  1 
ATOM   891  N N   . SER A 1 118 ? -37.385 -10.684 2.761   1.00 81.44  ? 117 SER A N   1 
ATOM   892  C CA  . SER A 1 118 ? -36.209 -11.320 2.174   1.00 81.44  ? 117 SER A CA  1 
ATOM   893  C C   . SER A 1 118 ? -36.564 -12.290 1.056   1.00 81.44  ? 117 SER A C   1 
ATOM   894  O O   . SER A 1 118 ? -35.698 -12.620 0.239   1.00 81.44  ? 117 SER A O   1 
ATOM   895  C CB  . SER A 1 118 ? -35.411 -12.057 3.255   1.00 81.44  ? 117 SER A CB  1 
ATOM   896  O OG  . SER A 1 118 ? -34.320 -11.275 3.713   1.00 81.44  ? 117 SER A OG  1 
ATOM   897  N N   . GLY A 1 119 ? -37.813 -12.738 0.990   1.00 87.88  ? 118 GLY A N   1 
ATOM   898  C CA  . GLY A 1 119 ? -38.227 -13.810 0.114   1.00 87.88  ? 118 GLY A CA  1 
ATOM   899  C C   . GLY A 1 119 ? -38.743 -15.021 0.859   1.00 87.88  ? 118 GLY A C   1 
ATOM   900  O O   . GLY A 1 119 ? -39.480 -15.827 0.278   1.00 87.88  ? 118 GLY A O   1 
ATOM   901  N N   . GLY A 1 120 ? -38.361 -15.171 2.128   1.00 95.97  ? 119 GLY A N   1 
ATOM   902  C CA  . GLY A 1 120 ? -38.924 -16.140 3.040   1.00 95.97  ? 119 GLY A CA  1 
ATOM   903  C C   . GLY A 1 120 ? -40.273 -15.765 3.604   1.00 95.97  ? 119 GLY A C   1 
ATOM   904  O O   . GLY A 1 120 ? -40.800 -16.490 4.452   1.00 95.97  ? 119 GLY A O   1 
ATOM   905  N N   . GLY A 1 121 ? -40.844 -14.640 3.166   1.00 110.71 ? 120 GLY A N   1 
ATOM   906  C CA  . GLY A 1 121 ? -42.181 -14.234 3.552   1.00 110.71 ? 120 GLY A CA  1 
ATOM   907  C C   . GLY A 1 121 ? -42.339 -13.731 4.971   1.00 110.71 ? 120 GLY A C   1 
ATOM   908  O O   . GLY A 1 121 ? -43.455 -13.354 5.352   1.00 110.71 ? 120 GLY A O   1 
ATOM   909  N N   . GLY A 1 122 ? -41.271 -13.690 5.758   1.00 92.61  ? 121 GLY A N   1 
ATOM   910  C CA  . GLY A 1 122 ? -41.381 -13.429 7.176   1.00 92.61  ? 121 GLY A CA  1 
ATOM   911  C C   . GLY A 1 122 ? -41.264 -14.708 7.989   1.00 92.61  ? 121 GLY A C   1 
ATOM   912  O O   . GLY A 1 122 ? -41.489 -15.818 7.502   1.00 92.61  ? 121 GLY A O   1 
ATOM   913  N N   . SER A 1 123 ? -40.907 -14.547 9.261   1.00 70.76  ? 122 SER A N   1 
ATOM   914  C CA  . SER A 1 123 ? -40.489 -15.693 10.052  1.00 70.76  ? 122 SER A CA  1 
ATOM   915  C C   . SER A 1 123 ? -41.193 -15.868 11.392  1.00 70.76  ? 122 SER A C   1 
ATOM   916  O O   . SER A 1 123 ? -41.087 -16.954 11.973  1.00 70.76  ? 122 SER A O   1 
ATOM   917  C CB  . SER A 1 123 ? -38.976 -15.630 10.303  1.00 70.76  ? 122 SER A CB  1 
ATOM   918  O OG  . SER A 1 123 ? -38.252 -15.923 9.118   1.00 70.76  ? 122 SER A OG  1 
ATOM   919  N N   . GLU A 1 124 ? -41.914 -14.867 11.895  1.00 56.52  ? 123 GLU A N   1 
ATOM   920  C CA  . GLU A 1 124 ? -42.372 -14.909 13.278  1.00 56.52  ? 123 GLU A CA  1 
ATOM   921  C C   . GLU A 1 124 ? -43.764 -15.506 13.456  1.00 56.52  ? 123 GLU A C   1 
ATOM   922  O O   . GLU A 1 124 ? -44.134 -15.803 14.598  1.00 56.52  ? 123 GLU A O   1 
ATOM   923  C CB  . GLU A 1 124 ? -42.350 -13.503 13.889  1.00 56.52  ? 123 GLU A CB  1 
ATOM   924  C CG  . GLU A 1 124 ? -43.648 -12.724 13.736  1.00 56.52  ? 123 GLU A CG  1 
ATOM   925  C CD  . GLU A 1 124 ? -43.792 -11.628 14.780  1.00 56.52  ? 123 GLU A CD  1 
ATOM   926  O OE1 . GLU A 1 124 ? -43.071 -11.676 15.798  1.00 56.52  ? 123 GLU A OE1 1 
ATOM   927  O OE2 . GLU A 1 124 ? -44.628 -10.720 14.583  1.00 56.52  ? 123 GLU A OE2 1 
ATOM   928  N N   . ILE A 1 125 ? -44.523 -15.696 12.370  1.00 45.59  ? 124 ILE A N   1 
ATOM   929  C CA  . ILE A 1 125 ? -45.928 -16.120 12.390  1.00 42.09  ? 124 ILE A CA  1 
ATOM   930  C C   . ILE A 1 125 ? -46.806 -14.971 12.864  1.00 44.27  ? 124 ILE A C   1 
ATOM   931  O O   . ILE A 1 125 ? -46.737 -14.561 14.027  1.00 40.81  ? 124 ILE A O   1 
ATOM   932  C CB  . ILE A 1 125 ? -46.171 -17.365 13.270  1.00 42.79  ? 124 ILE A CB  1 
ATOM   933  C CG1 . ILE A 1 125 ? -45.381 -18.572 12.770  1.00 45.20  ? 124 ILE A CG1 1 
ATOM   934  C CG2 . ILE A 1 125 ? -47.653 -17.687 13.330  1.00 33.86  ? 124 ILE A CG2 1 
ATOM   935  C CD1 . ILE A 1 125 ? -45.554 -19.795 13.652  1.00 35.45  ? 124 ILE A CD1 1 
ATOM   936  N N   . VAL A 1 126 ? -47.658 -14.465 11.978  1.00 36.14  ? 125 VAL A N   1 
ATOM   937  C CA  . VAL A 1 126 ? -48.532 -13.336 12.275  1.00 35.12  ? 125 VAL A CA  1 
ATOM   938  C C   . VAL A 1 126 ? -49.956 -13.845 12.448  1.00 36.87  ? 125 VAL A C   1 
ATOM   939  O O   . VAL A 1 126 ? -50.480 -14.560 11.582  1.00 38.13  ? 125 VAL A O   1 
ATOM   940  C CB  . VAL A 1 126 ? -48.458 -12.272 11.167  1.00 41.24  ? 125 VAL A CB  1 
ATOM   941  C CG1 . VAL A 1 126 ? -49.469 -11.166 11.419  1.00 40.20  ? 125 VAL A CG1 1 
ATOM   942  C CG2 . VAL A 1 126 ? -47.050 -11.698 11.078  1.00 40.33  ? 125 VAL A CG2 1 
ATOM   943  N N   . MET A 1 127 ? -50.579 -13.480 13.566  1.00 36.83  ? 126 MET A N   1 
ATOM   944  C CA  . MET A 1 127 ? -51.980 -13.800 13.833  1.00 34.76  ? 126 MET A CA  1 
ATOM   945  C C   . MET A 1 127 ? -52.800 -12.555 13.514  1.00 38.91  ? 126 MET A C   1 
ATOM   946  O O   . MET A 1 127 ? -52.813 -11.593 14.285  1.00 33.38  ? 126 MET A O   1 
ATOM   947  C CB  . MET A 1 127 ? -52.172 -14.238 15.282  1.00 34.72  ? 126 MET A CB  1 
ATOM   948  C CG  . MET A 1 127 ? -51.277 -15.383 15.716  1.00 37.14  ? 126 MET A CG  1 
ATOM   949  S SD  . MET A 1 127 ? -51.682 -16.949 14.930  1.00 37.51  ? 126 MET A SD  1 
ATOM   950  C CE  . MET A 1 127 ? -53.143 -17.437 15.840  1.00 31.64  ? 126 MET A CE  1 
ATOM   951  N N   . THR A 1 128 ? -53.577 -12.653 12.460  1.00 37.06  ? 127 THR A N   1 
ATOM   952  C CA  . THR A 1 128 ? -54.417 -11.558 12.009  1.00 38.33  ? 127 THR A CA  1 
ATOM   953  C C   . THR A 1 128 ? -55.843 -11.670 12.495  1.00 36.35  ? 127 THR A C   1 
ATOM   954  O O   . THR A 1 128 ? -56.524 -12.567 12.131  1.00 37.95  ? 127 THR A O   1 
ATOM   955  C CB  . THR A 1 128 ? -54.364 -11.363 10.478  1.00 42.35  ? 127 THR A CB  1 
ATOM   956  O OG1 . THR A 1 128 ? -53.736 -12.467 9.849   1.00 58.01  ? 127 THR A OG1 1 
ATOM   957  C CG2 . THR A 1 128 ? -53.530 -10.222 10.163  1.00 36.38  ? 127 THR A CG2 1 
ATOM   958  N N   . GLN A 1 129 ? -56.274 -10.736 13.323  1.00 33.48  ? 128 GLN A N   1 
ATOM   959  C CA  . GLN A 1 129 ? -57.614 -10.745 13.879  1.00 40.70  ? 128 GLN A CA  1 
ATOM   960  C C   . GLN A 1 129 ? -58.602 -9.928  13.129  1.00 44.96  ? 128 GLN A C   1 
ATOM   961  O O   . GLN A 1 129 ? -58.298 -8.912  12.630  1.00 44.81  ? 128 GLN A O   1 
ATOM   962  C CB  . GLN A 1 129 ? -57.622 -10.159 15.272  1.00 41.58  ? 128 GLN A CB  1 
ATOM   963  C CG  . GLN A 1 129 ? -57.223 -11.078 16.375  1.00 44.74  ? 128 GLN A CG  1 
ATOM   964  C CD  . GLN A 1 129 ? -57.965 -10.836 17.627  1.00 39.09  ? 128 GLN A CD  1 
ATOM   965  O OE1 . GLN A 1 129 ? -57.395 -10.768 18.671  1.00 31.83  ? 128 GLN A OE1 1 
ATOM   966  N NE2 . GLN A 1 129 ? -59.251 -10.740 17.528  1.00 35.56  ? 128 GLN A NE2 1 
ATOM   967  N N   . SER A 1 130 ? -59.827 -10.363 13.108  1.00 44.49  ? 129 SER A N   1 
ATOM   968  C CA  . SER A 1 130 ? -60.842 -9.618  12.449  1.00 44.49  ? 129 SER A CA  1 
ATOM   969  C C   . SER A 1 130 ? -62.094 -9.888  13.207  1.00 44.49  ? 129 SER A C   1 
ATOM   970  O O   . SER A 1 130 ? -62.400 -11.000 13.488  1.00 44.49  ? 129 SER A O   1 
ATOM   971  C CB  . SER A 1 130 ? -60.998 -10.081 11.024  1.00 44.49  ? 129 SER A CB  1 
ATOM   972  O OG  . SER A 1 130 ? -62.191 -9.595  10.470  1.00 44.49  ? 129 SER A OG  1 
ATOM   973  N N   . PRO A 1 131 ? -62.823 -8.849  13.565  1.00 42.63  ? 130 PRO A N   1 
ATOM   974  C CA  . PRO A 1 131 ? -62.614 -7.449  13.252  1.00 42.63  ? 130 PRO A CA  1 
ATOM   975  C C   . PRO A 1 131 ? -61.953 -6.737  14.384  1.00 42.63  ? 130 PRO A C   1 
ATOM   976  O O   . PRO A 1 131 ? -61.933 -7.234  15.430  1.00 42.63  ? 130 PRO A O   1 
ATOM   977  C CB  . PRO A 1 131 ? -64.024 -6.959  13.126  1.00 42.63  ? 130 PRO A CB  1 
ATOM   978  C CG  . PRO A 1 131 ? -64.718 -7.701  14.165  1.00 42.63  ? 130 PRO A CG  1 
ATOM   979  C CD  . PRO A 1 131 ? -64.110 -9.052  14.220  1.00 42.63  ? 130 PRO A CD  1 
ATOM   980  N N   . LYS A 1 132 ? -61.437 -5.556  14.180  1.00 38.09  ? 131 LYS A N   1 
ATOM   981  C CA  . LYS A 1 132 ? -60.800 -4.856  15.249  1.00 43.54  ? 131 LYS A CA  1 
ATOM   982  C C   . LYS A 1 132 ? -61.773 -4.218  16.177  1.00 38.30  ? 131 LYS A C   1 
ATOM   983  O O   . LYS A 1 132 ? -61.480 -4.021  17.318  1.00 39.01  ? 131 LYS A O   1 
ATOM   984  C CB  . LYS A 1 132 ? -59.883 -3.803  14.678  1.00 51.25  ? 131 LYS A CB  1 
ATOM   985  C CG  . LYS A 1 132 ? -59.002 -4.320  13.568  1.00 63.94  ? 131 LYS A CG  1 
ATOM   986  C CD  . LYS A 1 132 ? -58.140 -3.229  12.957  1.00 82.13  ? 131 LYS A CD  1 
ATOM   987  C CE  . LYS A 1 132 ? -56.800 -3.784  12.487  1.00 84.31  ? 131 LYS A CE  1 
ATOM   988  N NZ  . LYS A 1 132 ? -56.010 -2.810  11.688  1.00 90.79  ? 131 LYS A NZ  1 
ATOM   989  N N   . PHE A 1 133 ? -62.928 -3.853  15.671  1.00 40.69  ? 132 PHE A N   1 
ATOM   990  C CA  . PHE A 1 133 ? -63.946 -3.225  16.477  1.00 46.24  ? 132 PHE A CA  1 
ATOM   991  C C   . PHE A 1 133 ? -65.299 -3.872  16.245  1.00 48.34  ? 132 PHE A C   1 
ATOM   992  O O   . PHE A 1 133 ? -65.575 -4.382  15.194  1.00 49.32  ? 132 PHE A O   1 
ATOM   993  C CB  . PHE A 1 133 ? -64.011 -1.734  16.184  1.00 26.57  ? 132 PHE A CB  1 
ATOM   994  N N   . MET A 1 134 ? -66.154 -3.848  17.248  1.00 43.53  ? 133 MET A N   1 
ATOM   995  C CA  . MET A 1 134 ? -67.462 -4.432  17.120  1.00 46.86  ? 133 MET A CA  1 
ATOM   996  C C   . MET A 1 134 ? -68.448 -3.789  18.025  1.00 45.94  ? 133 MET A C   1 
ATOM   997  O O   . MET A 1 134 ? -68.222 -3.755  19.185  1.00 44.88  ? 133 MET A O   1 
ATOM   998  C CB  . MET A 1 134 ? -67.389 -5.870  17.528  1.00 45.12  ? 133 MET A CB  1 
ATOM   999  C CG  . MET A 1 134 ? -68.430 -6.744  16.917  1.00 62.45  ? 133 MET A CG  1 
ATOM   1000 S SD  . MET A 1 134 ? -67.856 -8.411  17.058  1.00 72.67  ? 133 MET A SD  1 
ATOM   1001 C CE  . MET A 1 134 ? -66.940 -8.264  18.544  1.00 48.90  ? 133 MET A CE  1 
ATOM   1002 N N   . SER A 1 135 ? -69.547 -3.280  17.490  1.00 43.48  ? 134 SER A N   1 
ATOM   1003 C CA  . SER A 1 135 ? -70.595 -2.721  18.325  1.00 44.52  ? 134 SER A CA  1 
ATOM   1004 C C   . SER A 1 135 ? -71.717 -3.713  18.281  1.00 42.83  ? 134 SER A C   1 
ATOM   1005 O O   . SER A 1 135 ? -72.224 -3.987  17.245  1.00 47.93  ? 134 SER A O   1 
ATOM   1006 C CB  . SER A 1 135 ? -71.055 -1.373  17.856  1.00 46.34  ? 134 SER A CB  1 
ATOM   1007 O OG  . SER A 1 135 ? -71.114 -0.486  18.931  1.00 54.76  ? 134 SER A OG  1 
ATOM   1008 N N   . THR A 1 136 ? -72.109 -4.213  19.436  1.00 56.17  ? 135 THR A N   1 
ATOM   1009 C CA  . THR A 1 136 ? -73.097 -5.273  19.530  1.00 54.79  ? 135 THR A CA  1 
ATOM   1010 C C   . THR A 1 136 ? -74.265 -4.832  20.403  1.00 56.17  ? 135 THR A C   1 
ATOM   1011 O O   . THR A 1 136 ? -74.164 -3.883  21.184  1.00 57.88  ? 135 THR A O   1 
ATOM   1012 C CB  . THR A 1 136 ? -72.473 -6.553  20.111  1.00 54.70  ? 135 THR A CB  1 
ATOM   1013 O OG1 . THR A 1 136 ? -71.154 -6.730  19.581  1.00 51.50  ? 135 THR A OG1 1 
ATOM   1014 C CG2 . THR A 1 136 ? -73.310 -7.773  19.764  1.00 54.25  ? 135 THR A CG2 1 
ATOM   1015 N N   . SER A 1 137 ? -75.385 -5.530  20.248  1.00 56.96  ? 136 SER A N   1 
ATOM   1016 C CA  . SER A 1 137 ? -76.516 -5.415  21.153  1.00 56.01  ? 136 SER A CA  1 
ATOM   1017 C C   . SER A 1 137 ? -76.532 -6.613  22.095  1.00 55.93  ? 136 SER A C   1 
ATOM   1018 O O   . SER A 1 137 ? -75.994 -7.677  21.780  1.00 57.37  ? 136 SER A O   1 
ATOM   1019 C CB  . SER A 1 137 ? -77.832 -5.335  20.375  1.00 66.20  ? 136 SER A CB  1 
ATOM   1020 O OG  . SER A 1 137 ? -77.763 -4.354  19.354  1.00 69.75  ? 136 SER A OG  1 
ATOM   1021 N N   . ILE A 1 138 ? -77.141 -6.423  23.266  1.00 47.80  ? 137 ILE A N   1 
ATOM   1022 C CA  . ILE A 1 138 ? -77.274 -7.516  24.222  1.00 44.06  ? 137 ILE A CA  1 
ATOM   1023 C C   . ILE A 1 138 ? -78.069 -8.644  23.583  1.00 49.30  ? 137 ILE A C   1 
ATOM   1024 O O   . ILE A 1 138 ? -79.155 -8.426  23.030  1.00 52.56  ? 137 ILE A O   1 
ATOM   1025 C CB  . ILE A 1 138 ? -77.949 -7.024  25.511  1.00 49.59  ? 137 ILE A CB  1 
ATOM   1026 C CG1 . ILE A 1 138 ? -77.079 -5.986  26.226  1.00 48.27  ? 137 ILE A CG1 1 
ATOM   1027 C CG2 . ILE A 1 138 ? -78.261 -8.197  26.431  1.00 47.64  ? 137 ILE A CG2 1 
ATOM   1028 C CD1 . ILE A 1 138 ? -76.090 -6.579  27.212  1.00 38.48  ? 137 ILE A CD1 1 
ATOM   1029 N N   . GLY A 1 139 ? -77.525 -9.856  23.643  1.00 48.31  ? 138 GLY A N   1 
ATOM   1030 C CA  . GLY A 1 139 ? -78.208 -11.029 23.142  1.00 50.36  ? 138 GLY A CA  1 
ATOM   1031 C C   . GLY A 1 139 ? -77.836 -11.459 21.740  1.00 49.21  ? 138 GLY A C   1 
ATOM   1032 O O   . GLY A 1 139 ? -78.334 -12.493 21.279  1.00 51.01  ? 138 GLY A O   1 
ATOM   1033 N N   . ASP A 1 140 ? -76.986 -10.710 21.043  1.00 51.85  ? 139 ASP A N   1 
ATOM   1034 C CA  . ASP A 1 140 ? -76.572 -11.123 19.712  1.00 48.65  ? 139 ASP A CA  1 
ATOM   1035 C C   . ASP A 1 140 ? -75.517 -12.224 19.797  1.00 50.76  ? 139 ASP A C   1 
ATOM   1036 O O   . ASP A 1 140 ? -75.024 -12.575 20.872  1.00 45.68  ? 139 ASP A O   1 
ATOM   1037 C CB  . ASP A 1 140 ? -76.021 -9.941  18.917  1.00 48.30  ? 139 ASP A CB  1 
ATOM   1038 C CG  . ASP A 1 140 ? -77.030 -8.827  18.739  1.00 56.29  ? 139 ASP A CG  1 
ATOM   1039 O OD1 . ASP A 1 140 ? -78.245 -9.103  18.807  1.00 59.28  ? 139 ASP A OD1 1 
ATOM   1040 O OD2 . ASP A 1 140 ? -76.601 -7.672  18.527  1.00 62.30  ? 139 ASP A OD2 1 
ATOM   1041 N N   . ARG A 1 141 ? -75.107 -12.745 18.662  1.00 49.17  ? 140 ARG A N   1 
ATOM   1042 C CA  . ARG A 1 141 ? -74.086 -13.761 18.608  1.00 51.10  ? 140 ARG A CA  1 
ATOM   1043 C C   . ARG A 1 141 ? -73.027 -13.184 17.715  1.00 46.27  ? 140 ARG A C   1 
ATOM   1044 O O   . ARG A 1 141 ? -73.323 -12.791 16.623  1.00 46.67  ? 140 ARG A O   1 
ATOM   1045 C CB  . ARG A 1 141 ? -74.652 -15.019 17.992  1.00 54.44  ? 140 ARG A CB  1 
ATOM   1046 C CG  . ARG A 1 141 ? -73.646 -15.972 17.379  1.00 64.53  ? 140 ARG A CG  1 
ATOM   1047 C CD  . ARG A 1 141 ? -74.276 -17.312 17.058  1.00 76.48  ? 140 ARG A CD  1 
ATOM   1048 N NE  . ARG A 1 141 ? -75.447 -17.533 17.887  1.00 94.20  ? 140 ARG A NE  1 
ATOM   1049 C CZ  . ARG A 1 141 ? -76.676 -17.775 17.439  1.00 101.06 ? 140 ARG A CZ  1 
ATOM   1050 N NH1 . ARG A 1 141 ? -76.935 -17.852 16.142  1.00 101.18 ? 140 ARG A NH1 1 
ATOM   1051 N NH2 . ARG A 1 141 ? -77.652 -17.948 18.306  1.00 91.72  ? 140 ARG A NH2 1 
ATOM   1052 N N   . VAL A 1 142 ? -71.789 -13.126 18.169  1.00 42.08  ? 141 VAL A N   1 
ATOM   1053 C CA  . VAL A 1 142 ? -70.743 -12.526 17.388  1.00 43.75  ? 141 VAL A CA  1 
ATOM   1054 C C   . VAL A 1 142 ? -69.517 -13.377 17.206  1.00 41.18  ? 141 VAL A C   1 
ATOM   1055 O O   . VAL A 1 142 ? -69.206 -14.127 18.052  1.00 43.28  ? 141 VAL A O   1 
ATOM   1056 C CB  . VAL A 1 142 ? -70.295 -11.257 18.083  1.00 50.16  ? 141 VAL A CB  1 
ATOM   1057 C CG1 . VAL A 1 142 ? -71.385 -10.229 18.033  1.00 55.57  ? 141 VAL A CG1 1 
ATOM   1058 C CG2 . VAL A 1 142 ? -69.954 -11.541 19.521  1.00 49.61  ? 141 VAL A CG2 1 
ATOM   1059 N N   . ASN A 1 143 ? -68.820 -13.233 16.091  1.00 34.70  ? 142 ASN A N   1 
ATOM   1060 C CA  . ASN A 1 143 ? -67.610 -13.986 15.824  1.00 40.54  ? 142 ASN A CA  1 
ATOM   1061 C C   . ASN A 1 143 ? -66.356 -13.167 15.691  1.00 38.57  ? 142 ASN A C   1 
ATOM   1062 O O   . ASN A 1 143 ? -66.374 -12.115 15.174  1.00 40.08  ? 142 ASN A O   1 
ATOM   1063 C CB  . ASN A 1 143 ? -67.720 -14.811 14.551  1.00 42.96  ? 142 ASN A CB  1 
ATOM   1064 C CG  . ASN A 1 143 ? -69.036 -14.663 13.863  1.00 64.26  ? 142 ASN A CG  1 
ATOM   1065 O OD1 . ASN A 1 143 ? -70.018 -15.266 14.267  1.00 67.07  ? 142 ASN A OD1 1 
ATOM   1066 N ND2 . ASN A 1 143 ? -69.067 -13.892 12.792  1.00 67.80  ? 142 ASN A ND2 1 
ATOM   1067 N N   . ILE A 1 144 ? -65.256 -13.690 16.176  1.00 35.47  ? 143 ILE A N   1 
ATOM   1068 C CA  . ILE A 1 144 ? -63.961 -13.077 16.050  1.00 37.00  ? 143 ILE A CA  1 
ATOM   1069 C C   . ILE A 1 144 ? -63.111 -14.151 15.447  1.00 41.88  ? 143 ILE A C   1 
ATOM   1070 O O   . ILE A 1 144 ? -63.145 -15.245 15.884  1.00 38.30  ? 143 ILE A O   1 
ATOM   1071 C CB  . ILE A 1 144 ? -63.364 -12.707 17.386  1.00 40.27  ? 143 ILE A CB  1 
ATOM   1072 C CG1 . ILE A 1 144 ? -64.404 -12.050 18.235  1.00 59.98  ? 143 ILE A CG1 1 
ATOM   1073 C CG2 . ILE A 1 144 ? -62.255 -11.715 17.216  1.00 39.50  ? 143 ILE A CG2 1 
ATOM   1074 C CD1 . ILE A 1 144 ? -63.834 -11.412 19.461  1.00 41.12  ? 143 ILE A CD1 1 
ATOM   1075 N N   . THR A 1 145 ? -62.378 -13.848 14.402  1.00 41.63  ? 144 THR A N   1 
ATOM   1076 C CA  . THR A 1 145 ? -61.540 -14.837 13.782  1.00 39.41  ? 144 THR A CA  1 
ATOM   1077 C C   . THR A 1 145 ? -60.116 -14.410 13.834  1.00 38.65  ? 144 THR A C   1 
ATOM   1078 O O   . THR A 1 145 ? -59.818 -13.275 13.922  1.00 36.60  ? 144 THR A O   1 
ATOM   1079 C CB  . THR A 1 145 ? -61.927 -15.100 12.344  1.00 48.20  ? 144 THR A CB  1 
ATOM   1080 O OG1 . THR A 1 145 ? -61.562 -13.986 11.560  1.00 54.43  ? 144 THR A OG1 1 
ATOM   1081 C CG2 . THR A 1 145 ? -63.379 -15.300 12.241  1.00 42.84  ? 144 THR A CG2 1 
ATOM   1082 N N   . CYS A 1 146 ? -59.234 -15.366 13.775  1.00 31.88  ? 145 CYS A N   1 
ATOM   1083 C CA  . CYS A 1 146 ? -57.843 -15.094 13.870  1.00 37.54  ? 145 CYS A CA  1 
ATOM   1084 C C   . CYS A 1 146 ? -57.191 -16.054 12.894  1.00 37.19  ? 145 CYS A C   1 
ATOM   1085 O O   . CYS A 1 146 ? -57.472 -17.204 12.907  1.00 39.34  ? 145 CYS A O   1 
ATOM   1086 C CB  . CYS A 1 146 ? -57.480 -15.282 15.323  1.00 41.86  ? 145 CYS A CB  1 
ATOM   1087 S SG  . CYS A 1 146 ? -55.834 -14.872 15.724  1.00 66.42  ? 145 CYS A SG  1 
ATOM   1088 N N   . LYS A 1 147 ? -56.359 -15.536 12.001  1.00 41.88  ? 146 LYS A N   1 
ATOM   1089 C CA  . LYS A 1 147 ? -55.754 -16.309 10.928  1.00 39.08  ? 146 LYS A CA  1 
ATOM   1090 C C   . LYS A 1 147 ? -54.240 -16.313 11.081  1.00 38.62  ? 146 LYS A C   1 
ATOM   1091 O O   . LYS A 1 147 ? -53.626 -15.269 11.323  1.00 44.55  ? 146 LYS A O   1 
ATOM   1092 C CB  . LYS A 1 147 ? -56.149 -15.738 9.562   1.00 42.96  ? 146 LYS A CB  1 
ATOM   1093 C CG  . LYS A 1 147 ? -55.827 -16.638 8.382   1.00 60.21  ? 146 LYS A CG  1 
ATOM   1094 C CD  . LYS A 1 147 ? -56.495 -16.128 7.114   1.00 71.69  ? 146 LYS A CD  1 
ATOM   1095 C CE  . LYS A 1 147 ? -57.964 -15.805 7.362   1.00 77.14  ? 146 LYS A CE  1 
ATOM   1096 N NZ  . LYS A 1 147 ? -58.728 -15.621 6.097   1.00 62.57  ? 146 LYS A NZ  1 
ATOM   1097 N N   . ALA A 1 148 ? -53.643 -17.492 10.933  1.00 34.85  ? 147 ALA A N   1 
ATOM   1098 C CA  . ALA A 1 148 ? -52.209 -17.680 11.099  1.00 38.64  ? 147 ALA A CA  1 
ATOM   1099 C C   . ALA A 1 148 ? -51.538 -17.848 9.742   1.00 44.60  ? 147 ALA A C   1 
ATOM   1100 O O   . ALA A 1 148 ? -52.093 -18.484 8.840   1.00 42.74  ? 147 ALA A O   1 
ATOM   1101 C CB  . ALA A 1 148 ? -51.918 -18.898 11.979  1.00 34.77  ? 147 ALA A CB  1 
ATOM   1102 N N   . THR A 1 149 ? -50.329 -17.282 9.606   1.00 36.86  ? 148 THR A N   1 
ATOM   1103 C CA  . THR A 1 149 ? -49.526 -17.359 8.382   1.00 35.94  ? 148 THR A CA  1 
ATOM   1104 C C   . THR A 1 149 ? -48.872 -18.722 8.197   1.00 38.20  ? 148 THR A C   1 
ATOM   1105 O O   . THR A 1 149 ? -48.084 -18.904 7.257   1.00 34.88  ? 148 THR A O   1 
ATOM   1106 C CB  . THR A 1 149 ? -48.454 -16.265 8.378   1.00 37.46  ? 148 THR A CB  1 
ATOM   1107 O OG1 . THR A 1 149 ? -47.567 -16.451 9.487   1.00 33.57  ? 148 THR A OG1 1 
ATOM   1108 C CG2 . THR A 1 149 ? -49.097 -14.888 8.482   1.00 33.68  ? 148 THR A CG2 1 
ATOM   1109 N N   . GLN A 1 150 ? -49.211 -19.658 9.080   1.00 30.20  ? 149 GLN A N   1 
ATOM   1110 C CA  . GLN A 1 150 ? -48.672 -21.009 9.070   1.00 30.64  ? 149 GLN A CA  1 
ATOM   1111 C C   . GLN A 1 150 ? -49.624 -21.906 9.851   1.00 26.88  ? 149 GLN A C   1 
ATOM   1112 O O   . GLN A 1 150 ? -50.351 -21.437 10.732  1.00 31.74  ? 149 GLN A O   1 
ATOM   1113 C CB  . GLN A 1 150 ? -47.256 -21.045 9.668   1.00 34.18  ? 149 GLN A CB  1 
ATOM   1114 C CG  . GLN A 1 150 ? -47.002 -22.146 10.697  1.00 37.50  ? 149 GLN A CG  1 
ATOM   1115 C CD  . GLN A 1 150 ? -45.532 -22.319 11.023  1.00 60.07  ? 149 GLN A CD  1 
ATOM   1116 O OE1 . GLN A 1 150 ? -44.743 -21.382 10.905  1.00 62.74  ? 149 GLN A OE1 1 
ATOM   1117 N NE2 . GLN A 1 150 ? -45.156 -23.525 11.432  1.00 58.69  ? 149 GLN A NE2 1 
ATOM   1118 N N   . ASN A 1 151 ? -49.644 -23.188 9.492   1.00 28.88  ? 150 ASN A N   1 
ATOM   1119 C CA  . ASN A 1 151 ? -50.417 -24.171 10.246  1.00 35.16  ? 150 ASN A CA  1 
ATOM   1120 C C   . ASN A 1 151 ? -49.863 -24.261 11.664  1.00 33.71  ? 150 ASN A C   1 
ATOM   1121 O O   . ASN A 1 151 ? -48.760 -24.774 11.877  1.00 31.97  ? 150 ASN A O   1 
ATOM   1122 C CB  . ASN A 1 151 ? -50.377 -25.527 9.546   1.00 35.57  ? 150 ASN A CB  1 
ATOM   1123 C CG  . ASN A 1 151 ? -51.210 -26.591 10.251  1.00 39.65  ? 150 ASN A CG  1 
ATOM   1124 O OD1 . ASN A 1 151 ? -51.799 -26.349 11.298  1.00 28.88  ? 150 ASN A OD1 1 
ATOM   1125 N ND2 . ASN A 1 151 ? -51.264 -27.780 9.662   1.00 40.01  ? 150 ASN A ND2 1 
ATOM   1126 N N   . VAL A 1 152 ? -50.620 -23.751 12.631  1.00 33.58  ? 151 VAL A N   1 
ATOM   1127 C CA  . VAL A 1 152 ? -50.271 -23.857 14.039  1.00 27.19  ? 151 VAL A CA  1 
ATOM   1128 C C   . VAL A 1 152 ? -51.100 -24.939 14.734  1.00 31.18  ? 151 VAL A C   1 
ATOM   1129 O O   . VAL A 1 152 ? -51.156 -24.982 15.963  1.00 29.24  ? 151 VAL A O   1 
ATOM   1130 C CB  . VAL A 1 152 ? -50.410 -22.505 14.756  1.00 30.83  ? 151 VAL A CB  1 
ATOM   1131 C CG1 . VAL A 1 152 ? -49.421 -21.503 14.187  1.00 29.52  ? 151 VAL A CG1 1 
ATOM   1132 C CG2 . VAL A 1 152 ? -51.831 -21.986 14.628  1.00 30.60  ? 151 VAL A CG2 1 
ATOM   1133 N N   . ARG A 1 153 ? -51.746 -25.811 13.956  1.00 38.21  ? 152 ARG A N   1 
ATOM   1134 C CA  . ARG A 1 153 ? -52.584 -26.891 14.464  1.00 33.26  ? 152 ARG A CA  1 
ATOM   1135 C C   . ARG A 1 153 ? -53.673 -26.358 15.386  1.00 37.52  ? 152 ARG A C   1 
ATOM   1136 O O   . ARG A 1 153 ? -54.573 -25.638 14.943  1.00 39.29  ? 152 ARG A O   1 
ATOM   1137 C CB  . ARG A 1 153 ? -51.729 -27.942 15.176  1.00 34.48  ? 152 ARG A CB  1 
ATOM   1138 C CG  . ARG A 1 153 ? -50.508 -28.369 14.375  1.00 36.24  ? 152 ARG A CG  1 
ATOM   1139 C CD  . ARG A 1 153 ? -50.385 -29.879 14.267  1.00 44.65  ? 152 ARG A CD  1 
ATOM   1140 N NE  . ARG A 1 153 ? -48.991 -30.301 14.364  1.00 40.65  ? 152 ARG A NE  1 
ATOM   1141 C CZ  . ARG A 1 153 ? -48.549 -31.520 14.072  1.00 48.67  ? 152 ARG A CZ  1 
ATOM   1142 N NH1 . ARG A 1 153 ? -49.395 -32.444 13.645  1.00 43.41  ? 152 ARG A NH1 1 
ATOM   1143 N NH2 . ARG A 1 153 ? -47.261 -31.811 14.199  1.00 49.55  ? 152 ARG A NH2 1 
ATOM   1144 N N   . THR A 1 154 ? -53.606 -26.711 16.669  1.00 33.29  ? 153 THR A N   1 
ATOM   1145 C CA  . THR A 1 154 ? -54.563 -26.232 17.657  1.00 30.85  ? 153 THR A CA  1 
ATOM   1146 C C   . THR A 1 154 ? -53.891 -25.450 18.780  1.00 36.24  ? 153 THR A C   1 
ATOM   1147 O O   . THR A 1 154 ? -54.530 -25.177 19.802  1.00 31.93  ? 153 THR A O   1 
ATOM   1148 C CB  . THR A 1 154 ? -55.363 -27.405 18.234  1.00 35.77  ? 153 THR A CB  1 
ATOM   1149 O OG1 . THR A 1 154 ? -54.465 -28.338 18.847  1.00 32.57  ? 153 THR A OG1 1 
ATOM   1150 C CG2 . THR A 1 154 ? -56.141 -28.112 17.133  1.00 39.43  ? 153 THR A CG2 1 
ATOM   1151 N N   . ALA A 1 155 ? -52.622 -25.075 18.613  1.00 30.91  ? 154 ALA A N   1 
ATOM   1152 C CA  . ALA A 1 155 ? -51.880 -24.330 19.624  1.00 32.39  ? 154 ALA A CA  1 
ATOM   1153 C C   . ALA A 1 155 ? -52.348 -22.883 19.687  1.00 32.61  ? 154 ALA A C   1 
ATOM   1154 O O   . ALA A 1 155 ? -51.554 -21.959 19.483  1.00 32.52  ? 154 ALA A O   1 
ATOM   1155 C CB  . ALA A 1 155 ? -50.379 -24.385 19.334  1.00 28.81  ? 154 ALA A CB  1 
ATOM   1156 N N   . VAL A 1 156 ? -53.633 -22.672 19.965  1.00 30.41  ? 155 VAL A N   1 
ATOM   1157 C CA  . VAL A 1 156 ? -54.230 -21.344 19.963  1.00 27.41  ? 155 VAL A CA  1 
ATOM   1158 C C   . VAL A 1 156 ? -55.042 -21.165 21.237  1.00 29.67  ? 155 VAL A C   1 
ATOM   1159 O O   . VAL A 1 156 ? -55.825 -22.044 21.610  1.00 31.61  ? 155 VAL A O   1 
ATOM   1160 C CB  . VAL A 1 156 ? -55.109 -21.116 18.719  1.00 30.29  ? 155 VAL A CB  1 
ATOM   1161 C CG1 . VAL A 1 156 ? -55.925 -19.843 18.868  1.00 31.68  ? 155 VAL A CG1 1 
ATOM   1162 C CG2 . VAL A 1 156 ? -54.240 -21.042 17.481  1.00 28.50  ? 155 VAL A CG2 1 
ATOM   1163 N N   . THR A 1 157 ? -54.851 -20.026 21.897  1.00 30.63  ? 156 THR A N   1 
ATOM   1164 C CA  . THR A 1 157 ? -55.546 -19.683 23.129  1.00 28.02  ? 156 THR A CA  1 
ATOM   1165 C C   . THR A 1 157 ? -56.265 -18.355 22.945  1.00 32.27  ? 156 THR A C   1 
ATOM   1166 O O   . THR A 1 157 ? -55.668 -17.385 22.468  1.00 36.76  ? 156 THR A O   1 
ATOM   1167 C CB  . THR A 1 157 ? -54.570 -19.593 24.306  1.00 33.35  ? 156 THR A CB  1 
ATOM   1168 O OG1 . THR A 1 157 ? -53.677 -20.714 24.274  1.00 34.32  ? 156 THR A OG1 1 
ATOM   1169 C CG2 . THR A 1 157 ? -55.323 -19.594 25.626  1.00 28.97  ? 156 THR A CG2 1 
ATOM   1170 N N   . TRP A 1 158 ? -57.540 -18.318 23.322  1.00 32.78  ? 157 TRP A N   1 
ATOM   1171 C CA  . TRP A 1 158 ? -58.376 -17.127 23.251  1.00 31.27  ? 157 TRP A CA  1 
ATOM   1172 C C   . TRP A 1 158 ? -58.531 -16.547 24.649  1.00 27.20  ? 157 TRP A C   1 
ATOM   1173 O O   . TRP A 1 158 ? -58.995 -17.249 25.558  1.00 30.39  ? 157 TRP A O   1 
ATOM   1174 C CB  . TRP A 1 158 ? -59.752 -17.459 22.676  1.00 33.43  ? 157 TRP A CB  1 
ATOM   1175 C CG  . TRP A 1 158 ? -59.772 -17.656 21.204  1.00 34.39  ? 157 TRP A CG  1 
ATOM   1176 C CD1 . TRP A 1 158 ? -59.819 -18.843 20.533  1.00 32.55  ? 157 TRP A CD1 1 
ATOM   1177 C CD2 . TRP A 1 158 ? -59.757 -16.631 20.208  1.00 32.66  ? 157 TRP A CD2 1 
ATOM   1178 N NE1 . TRP A 1 158 ? -59.831 -18.618 19.178  1.00 35.95  ? 157 TRP A NE1 1 
ATOM   1179 C CE2 . TRP A 1 158 ? -59.794 -17.267 18.953  1.00 35.07  ? 157 TRP A CE2 1 
ATOM   1180 C CE3 . TRP A 1 158 ? -59.715 -15.235 20.258  1.00 33.56  ? 157 TRP A CE3 1 
ATOM   1181 C CZ2 . TRP A 1 158 ? -59.789 -16.554 17.757  1.00 37.19  ? 157 TRP A CZ2 1 
ATOM   1182 C CZ3 . TRP A 1 158 ? -59.711 -14.530 19.071  1.00 35.37  ? 157 TRP A CZ3 1 
ATOM   1183 C CH2 . TRP A 1 158 ? -59.749 -15.189 17.838  1.00 45.00  ? 157 TRP A CH2 1 
ATOM   1184 N N   . TYR A 1 159 ? -58.172 -15.269 24.805  1.00 35.81  ? 158 TYR A N   1 
ATOM   1185 C CA  . TYR A 1 159 ? -58.286 -14.556 26.068  1.00 33.72  ? 158 TYR A CA  1 
ATOM   1186 C C   . TYR A 1 159 ? -59.250 -13.382 25.950  1.00 36.03  ? 158 TYR A C   1 
ATOM   1187 O O   . TYR A 1 159 ? -59.410 -12.782 24.878  1.00 31.59  ? 158 TYR A O   1 
ATOM   1188 C CB  . TYR A 1 159 ? -56.940 -14.002 26.550  1.00 33.76  ? 158 TYR A CB  1 
ATOM   1189 C CG  . TYR A 1 159 ? -55.803 -14.990 26.600  1.00 28.02  ? 158 TYR A CG  1 
ATOM   1190 C CD1 . TYR A 1 159 ? -55.631 -15.826 27.694  1.00 31.74  ? 158 TYR A CD1 1 
ATOM   1191 C CD2 . TYR A 1 159 ? -54.879 -15.066 25.564  1.00 30.68  ? 158 TYR A CD2 1 
ATOM   1192 C CE1 . TYR A 1 159 ? -54.587 -16.725 27.747  1.00 31.29  ? 158 TYR A CE1 1 
ATOM   1193 C CE2 . TYR A 1 159 ? -53.830 -15.963 25.609  1.00 31.53  ? 158 TYR A CE2 1 
ATOM   1194 C CZ  . TYR A 1 159 ? -53.689 -16.789 26.704  1.00 30.58  ? 158 TYR A CZ  1 
ATOM   1195 O OH  . TYR A 1 159 ? -52.648 -17.684 26.756  1.00 33.64  ? 158 TYR A OH  1 
ATOM   1196 N N   . GLN A 1 160 ? -59.871 -13.058 27.085  1.00 31.51  ? 159 GLN A N   1 
ATOM   1197 C CA  . GLN A 1 160 ? -60.654 -11.847 27.285  1.00 30.13  ? 159 GLN A CA  1 
ATOM   1198 C C   . GLN A 1 160 ? -59.951 -10.969 28.312  1.00 34.54  ? 159 GLN A C   1 
ATOM   1199 O O   . GLN A 1 160 ? -59.369 -11.475 29.276  1.00 30.00  ? 159 GLN A O   1 
ATOM   1200 C CB  . GLN A 1 160 ? -62.073 -12.184 27.765  1.00 31.71  ? 159 GLN A CB  1 
ATOM   1201 C CG  . GLN A 1 160 ? -62.821 -11.027 28.425  1.00 34.82  ? 159 GLN A CG  1 
ATOM   1202 C CD  . GLN A 1 160 ? -64.120 -11.462 29.076  1.00 32.40  ? 159 GLN A CD  1 
ATOM   1203 O OE1 . GLN A 1 160 ? -64.220 -11.536 30.301  1.00 35.44  ? 159 GLN A OE1 1 
ATOM   1204 N NE2 . GLN A 1 160 ? -65.123 -11.748 28.258  1.00 34.73  ? 159 GLN A NE2 1 
ATOM   1205 N N   . GLN A 1 161 ? -59.998 -9.654  28.104  1.00 34.94  ? 160 GLN A N   1 
ATOM   1206 C CA  . GLN A 1 161 ? -59.385 -8.695  29.020  1.00 36.15  ? 160 GLN A CA  1 
ATOM   1207 C C   . GLN A 1 161 ? -60.353 -7.538  29.222  1.00 36.56  ? 160 GLN A C   1 
ATOM   1208 O O   . GLN A 1 161 ? -60.548 -6.724  28.313  1.00 40.42  ? 160 GLN A O   1 
ATOM   1209 C CB  . GLN A 1 161 ? -58.045 -8.195  28.485  1.00 39.44  ? 160 GLN A CB  1 
ATOM   1210 C CG  . GLN A 1 161 ? -57.366 -7.174  29.383  1.00 41.37  ? 160 GLN A CG  1 
ATOM   1211 C CD  . GLN A 1 161 ? -56.050 -6.684  28.813  1.00 40.11  ? 160 GLN A CD  1 
ATOM   1212 O OE1 . GLN A 1 161 ? -55.902 -6.548  27.599  1.00 44.88  ? 160 GLN A OE1 1 
ATOM   1213 N NE2 . GLN A 1 161 ? -55.084 -6.428  29.687  1.00 39.71  ? 160 GLN A NE2 1 
ATOM   1214 N N   . LYS A 1 162 ? -60.955 -7.467  30.406  1.00 43.80  ? 161 LYS A N   1 
ATOM   1215 C CA  . LYS A 1 162 ? -61.848 -6.369  30.728  1.00 45.52  ? 161 LYS A CA  1 
ATOM   1216 C C   . LYS A 1 162 ? -61.042 -5.100  30.994  1.00 42.12  ? 161 LYS A C   1 
ATOM   1217 O O   . LYS A 1 162 ? -59.867 -5.167  31.359  1.00 44.43  ? 161 LYS A O   1 
ATOM   1218 C CB  . LYS A 1 162 ? -62.716 -6.736  31.931  1.00 44.51  ? 161 LYS A CB  1 
ATOM   1219 C CG  . LYS A 1 162 ? -63.764 -7.793  31.613  1.00 44.29  ? 161 LYS A CG  1 
ATOM   1220 C CD  . LYS A 1 162 ? -64.565 -8.193  32.840  1.00 50.66  ? 161 LYS A CD  1 
ATOM   1221 C CE  . LYS A 1 162 ? -65.546 -9.313  32.517  1.00 53.49  ? 161 LYS A CE  1 
ATOM   1222 N NZ  . LYS A 1 162 ? -66.190 -9.856  33.747  1.00 53.77  ? 161 LYS A NZ  1 
ATOM   1223 N N   . PRO A 1 163 ? -61.651 -3.927  30.804  1.00 55.75  ? 162 PRO A N   1 
ATOM   1224 C CA  . PRO A 1 163 ? -60.894 -2.672  30.913  1.00 59.93  ? 162 PRO A CA  1 
ATOM   1225 C C   . PRO A 1 163 ? -60.252 -2.515  32.283  1.00 51.14  ? 162 PRO A C   1 
ATOM   1226 O O   . PRO A 1 163 ? -60.917 -2.615  33.317  1.00 56.50  ? 162 PRO A O   1 
ATOM   1227 C CB  . PRO A 1 163 ? -61.956 -1.594  30.662  1.00 62.33  ? 162 PRO A CB  1 
ATOM   1228 C CG  . PRO A 1 163 ? -63.032 -2.286  29.896  1.00 55.96  ? 162 PRO A CG  1 
ATOM   1229 C CD  . PRO A 1 163 ? -63.053 -3.692  30.413  1.00 50.14  ? 162 PRO A CD  1 
ATOM   1230 N N   . GLY A 1 164 ? -58.943 -2.270  32.284  1.00 51.76  ? 163 GLY A N   1 
ATOM   1231 C CA  . GLY A 1 164 ? -58.219 -2.094  33.527  1.00 56.21  ? 163 GLY A CA  1 
ATOM   1232 C C   . GLY A 1 164 ? -57.997 -3.359  34.320  1.00 60.70  ? 163 GLY A C   1 
ATOM   1233 O O   . GLY A 1 164 ? -57.753 -3.285  35.528  1.00 53.75  ? 163 GLY A O   1 
ATOM   1234 N N   . GLN A 1 165 ? -58.079 -4.523  33.681  1.00 57.87  ? 164 GLN A N   1 
ATOM   1235 C CA  . GLN A 1 165 ? -57.846 -5.804  34.335  1.00 54.65  ? 164 GLN A CA  1 
ATOM   1236 C C   . GLN A 1 165 ? -56.852 -6.614  33.508  1.00 46.33  ? 164 GLN A C   1 
ATOM   1237 O O   . GLN A 1 165 ? -56.421 -6.200  32.428  1.00 49.20  ? 164 GLN A O   1 
ATOM   1238 C CB  . GLN A 1 165 ? -59.156 -6.581  34.527  1.00 52.82  ? 164 GLN A CB  1 
ATOM   1239 C CG  . GLN A 1 165 ? -60.375 -5.727  34.864  1.00 60.28  ? 164 GLN A CG  1 
ATOM   1240 C CD  . GLN A 1 165 ? -60.373 -5.195  36.288  1.00 74.38  ? 164 GLN A CD  1 
ATOM   1241 O OE1 . GLN A 1 165 ? -59.391 -5.329  37.020  1.00 79.43  ? 164 GLN A OE1 1 
ATOM   1242 N NE2 . GLN A 1 165 ? -61.487 -4.591  36.689  1.00 66.05  ? 164 GLN A NE2 1 
ATOM   1243 N N   . SER A 1 166 ? -56.489 -7.781  34.027  1.00 43.21  ? 165 SER A N   1 
ATOM   1244 C CA  . SER A 1 166 ? -55.565 -8.678  33.354  1.00 45.63  ? 165 SER A CA  1 
ATOM   1245 C C   . SER A 1 166 ? -56.313 -9.586  32.387  1.00 45.20  ? 165 SER A C   1 
ATOM   1246 O O   . SER A 1 166 ? -57.512 -9.832  32.553  1.00 42.73  ? 165 SER A O   1 
ATOM   1247 C CB  . SER A 1 166 ? -54.808 -9.515  34.383  1.00 49.56  ? 165 SER A CB  1 
ATOM   1248 O OG  . SER A 1 166 ? -54.087 -8.689  35.282  1.00 56.43  ? 165 SER A OG  1 
ATOM   1249 N N   . PRO A 1 167 ? -55.640 -10.091 31.353  1.00 35.72  ? 166 PRO A N   1 
ATOM   1250 C CA  . PRO A 1 167 ? -56.292 -11.053 30.461  1.00 36.50  ? 166 PRO A CA  1 
ATOM   1251 C C   . PRO A 1 167 ? -56.679 -12.315 31.215  1.00 35.57  ? 166 PRO A C   1 
ATOM   1252 O O   . PRO A 1 167 ? -56.093 -12.659 32.242  1.00 36.27  ? 166 PRO A O   1 
ATOM   1253 C CB  . PRO A 1 167 ? -55.225 -11.336 29.397  1.00 37.64  ? 166 PRO A CB  1 
ATOM   1254 C CG  . PRO A 1 167 ? -54.307 -10.159 29.450  1.00 35.68  ? 166 PRO A CG  1 
ATOM   1255 C CD  . PRO A 1 167 ? -54.286 -9.740  30.887  1.00 34.27  ? 166 PRO A CD  1 
ATOM   1256 N N   . GLN A 1 168 ? -57.689 -13.006 30.695  1.00 34.75  ? 167 GLN A N   1 
ATOM   1257 C CA  . GLN A 1 168 ? -58.163 -14.238 31.308  1.00 34.38  ? 167 GLN A CA  1 
ATOM   1258 C C   . GLN A 1 168 ? -58.543 -15.231 30.224  1.00 33.82  ? 167 GLN A C   1 
ATOM   1259 O O   . GLN A 1 168 ? -59.225 -14.873 29.259  1.00 32.61  ? 167 GLN A O   1 
ATOM   1260 C CB  . GLN A 1 168 ? -59.344 -13.971 32.247  1.00 40.96  ? 167 GLN A CB  1 
ATOM   1261 C CG  . GLN A 1 168 ? -58.896 -13.640 33.662  1.00 48.45  ? 167 GLN A CG  1 
ATOM   1262 C CD  . GLN A 1 168 ? -60.007 -13.089 34.525  1.00 74.00  ? 167 GLN A CD  1 
ATOM   1263 O OE1 . GLN A 1 168 ? -61.154 -13.532 34.447  1.00 69.77  ? 167 GLN A OE1 1 
ATOM   1264 N NE2 . GLN A 1 168 ? -59.672 -12.109 35.356  1.00 48.46  ? 167 GLN A NE2 1 
ATOM   1265 N N   . ALA A 1 169 ? -58.105 -16.475 30.394  1.00 29.94  ? 168 ALA A N   1 
ATOM   1266 C CA  . ALA A 1 169 ? -58.257 -17.487 29.358  1.00 30.77  ? 168 ALA A CA  1 
ATOM   1267 C C   . ALA A 1 169 ? -59.725 -17.839 29.158  1.00 30.48  ? 168 ALA A C   1 
ATOM   1268 O O   . ALA A 1 169 ? -60.413 -18.240 30.102  1.00 32.51  ? 168 ALA A O   1 
ATOM   1269 C CB  . ALA A 1 169 ? -57.453 -18.733 29.721  1.00 28.55  ? 168 ALA A CB  1 
ATOM   1270 N N   . LEU A 1 170 ? -60.200 -17.685 27.923  1.00 29.69  ? 169 LEU A N   1 
ATOM   1271 C CA  . LEU A 1 170 ? -61.522 -18.159 27.530  1.00 28.04  ? 169 LEU A CA  1 
ATOM   1272 C C   . LEU A 1 170 ? -61.441 -19.559 26.935  1.00 32.26  ? 169 LEU A C   1 
ATOM   1273 O O   . LEU A 1 170 ? -62.055 -20.500 27.448  1.00 33.48  ? 169 LEU A O   1 
ATOM   1274 C CB  . LEU A 1 170 ? -62.159 -17.202 26.517  1.00 33.48  ? 169 LEU A CB  1 
ATOM   1275 C CG  . LEU A 1 170 ? -62.657 -15.849 27.012  1.00 35.19  ? 169 LEU A CG  1 
ATOM   1276 C CD1 . LEU A 1 170 ? -63.315 -15.100 25.868  1.00 37.26  ? 169 LEU A CD1 1 
ATOM   1277 C CD2 . LEU A 1 170 ? -63.626 -16.035 28.168  1.00 35.39  ? 169 LEU A CD2 1 
ATOM   1278 N N   . ILE A 1 171 ? -60.685 -19.706 25.852  1.00 34.00  ? 170 ILE A N   1 
ATOM   1279 C CA  . ILE A 1 171 ? -60.599 -20.966 25.122  1.00 31.44  ? 170 ILE A CA  1 
ATOM   1280 C C   . ILE A 1 171 ? -59.142 -21.398 25.079  1.00 32.24  ? 170 ILE A C   1 
ATOM   1281 O O   . ILE A 1 171 ? -58.247 -20.561 24.934  1.00 30.83  ? 170 ILE A O   1 
ATOM   1282 C CB  . ILE A 1 171 ? -61.174 -20.840 23.692  1.00 35.01  ? 170 ILE A CB  1 
ATOM   1283 C CG1 . ILE A 1 171 ? -62.591 -20.263 23.721  1.00 31.17  ? 170 ILE A CG1 1 
ATOM   1284 C CG2 . ILE A 1 171 ? -61.183 -22.192 22.991  1.00 33.02  ? 170 ILE A CG2 1 
ATOM   1285 C CD1 . ILE A 1 171 ? -63.609 -21.172 24.368  1.00 35.68  ? 170 ILE A CD1 1 
ATOM   1286 N N   . PHE A 1 172 ? -58.897 -22.698 25.204  1.00 34.64  ? 171 PHE A N   1 
ATOM   1287 C CA  . PHE A 1 172 ? -57.544 -23.217 25.088  1.00 31.77  ? 171 PHE A CA  1 
ATOM   1288 C C   . PHE A 1 172 ? -57.534 -24.419 24.157  1.00 34.56  ? 171 PHE A C   1 
ATOM   1289 O O   . PHE A 1 172 ? -58.499 -25.186 24.095  1.00 34.24  ? 171 PHE A O   1 
ATOM   1290 C CB  . PHE A 1 172 ? -56.953 -23.577 26.461  1.00 30.78  ? 171 PHE A CB  1 
ATOM   1291 C CG  . PHE A 1 172 ? -57.385 -24.913 26.987  1.00 31.28  ? 171 PHE A CG  1 
ATOM   1292 C CD1 . PHE A 1 172 ? -58.646 -25.090 27.535  1.00 29.67  ? 171 PHE A CD1 1 
ATOM   1293 C CD2 . PHE A 1 172 ? -56.513 -25.989 26.964  1.00 38.34  ? 171 PHE A CD2 1 
ATOM   1294 C CE1 . PHE A 1 172 ? -59.033 -26.320 28.032  1.00 36.33  ? 171 PHE A CE1 1 
ATOM   1295 C CE2 . PHE A 1 172 ? -56.894 -27.220 27.457  1.00 36.93  ? 171 PHE A CE2 1 
ATOM   1296 C CZ  . PHE A 1 172 ? -58.156 -27.386 27.991  1.00 40.79  ? 171 PHE A CZ  1 
ATOM   1297 N N   . LEU A 1 173 ? -56.427 -24.564 23.428  1.00 33.83  ? 172 LEU A N   1 
ATOM   1298 C CA  . LEU A 1 173 ? -56.292 -25.571 22.378  1.00 30.70  ? 172 LEU A CA  1 
ATOM   1299 C C   . LEU A 1 173 ? -57.431 -25.450 21.367  1.00 37.88  ? 172 LEU A C   1 
ATOM   1300 O O   . LEU A 1 173 ? -58.155 -26.408 21.080  1.00 36.66  ? 172 LEU A O   1 
ATOM   1301 C CB  . LEU A 1 173 ? -56.204 -26.977 22.971  1.00 32.29  ? 172 LEU A CB  1 
ATOM   1302 C CG  . LEU A 1 173 ? -54.847 -27.284 23.611  1.00 37.42  ? 172 LEU A CG  1 
ATOM   1303 C CD1 . LEU A 1 173 ? -54.931 -28.493 24.529  1.00 32.31  ? 172 LEU A CD1 1 
ATOM   1304 C CD2 . LEU A 1 173 ? -53.797 -27.499 22.532  1.00 36.84  ? 172 LEU A CD2 1 
ATOM   1305 N N   . ALA A 1 174 ? -57.600 -24.229 20.855  1.00 30.84  ? 173 ALA A N   1 
ATOM   1306 C CA  . ALA A 1 174 ? -58.508 -23.897 19.761  1.00 35.54  ? 173 ALA A CA  1 
ATOM   1307 C C   . ALA A 1 174 ? -59.985 -23.975 20.138  1.00 36.00  ? 173 ALA A C   1 
ATOM   1308 O O   . ALA A 1 174 ? -60.747 -23.054 19.826  1.00 35.78  ? 173 ALA A O   1 
ATOM   1309 C CB  . ALA A 1 174 ? -58.235 -24.792 18.547  1.00 36.08  ? 173 ALA A CB  1 
ATOM   1310 N N   . SER A 1 175 ? -60.413 -25.052 20.802  1.00 34.86  ? 174 SER A N   1 
ATOM   1311 C CA  . SER A 1 175 ? -61.838 -25.334 20.904  1.00 36.11  ? 174 SER A CA  1 
ATOM   1312 C C   . SER A 1 175 ? -62.343 -25.706 22.293  1.00 32.69  ? 174 SER A C   1 
ATOM   1313 O O   . SER A 1 175 ? -63.530 -26.022 22.427  1.00 36.27  ? 174 SER A O   1 
ATOM   1314 C CB  . SER A 1 175 ? -62.216 -26.461 19.931  1.00 37.46  ? 174 SER A CB  1 
ATOM   1315 O OG  . SER A 1 175 ? -61.407 -27.604 20.145  1.00 34.69  ? 174 SER A OG  1 
ATOM   1316 N N   . ASN A 1 176 ? -61.506 -25.669 23.323  1.00 36.86  ? 175 ASN A N   1 
ATOM   1317 C CA  . ASN A 1 176 ? -61.897 -26.123 24.652  1.00 31.87  ? 175 ASN A CA  1 
ATOM   1318 C C   . ASN A 1 176 ? -62.045 -24.937 25.596  1.00 37.38  ? 175 ASN A C   1 
ATOM   1319 O O   . ASN A 1 176 ? -61.149 -24.091 25.683  1.00 37.73  ? 175 ASN A O   1 
ATOM   1320 C CB  . ASN A 1 176 ? -60.879 -27.120 25.203  1.00 34.34  ? 175 ASN A CB  1 
ATOM   1321 C CG  . ASN A 1 176 ? -60.638 -28.275 24.260  1.00 42.09  ? 175 ASN A CG  1 
ATOM   1322 O OD1 . ASN A 1 176 ? -61.409 -29.234 24.228  1.00 38.73  ? 175 ASN A OD1 1 
ATOM   1323 N ND2 . ASN A 1 176 ? -59.564 -28.191 23.482  1.00 35.88  ? 175 ASN A ND2 1 
ATOM   1324 N N   . ARG A 1 177 ? -63.174 -24.885 26.301  1.00 30.64  ? 176 ARG A N   1 
ATOM   1325 C CA  . ARG A 1 177 ? -63.416 -23.816 27.259  1.00 35.44  ? 176 ARG A CA  1 
ATOM   1326 C C   . ARG A 1 177 ? -62.523 -23.981 28.480  1.00 39.10  ? 176 ARG A C   1 
ATOM   1327 O O   . ARG A 1 177 ? -62.367 -25.084 29.011  1.00 34.38  ? 176 ARG A O   1 
ATOM   1328 C CB  . ARG A 1 177 ? -64.880 -23.805 27.695  1.00 36.91  ? 176 ARG A CB  1 
ATOM   1329 C CG  . ARG A 1 177 ? -65.819 -23.125 26.724  1.00 40.91  ? 176 ARG A CG  1 
ATOM   1330 C CD  . ARG A 1 177 ? -67.196 -22.919 27.337  1.00 48.73  ? 176 ARG A CD  1 
ATOM   1331 N NE  . ARG A 1 177 ? -67.949 -24.163 27.455  1.00 54.46  ? 176 ARG A NE  1 
ATOM   1332 C CZ  . ARG A 1 177 ? -68.681 -24.688 26.477  1.00 79.77  ? 176 ARG A CZ  1 
ATOM   1333 N NH1 . ARG A 1 177 ? -68.753 -24.081 25.301  1.00 77.35  ? 176 ARG A NH1 1 
ATOM   1334 N NH2 . ARG A 1 177 ? -69.337 -25.823 26.672  1.00 63.29  ? 176 ARG A NH2 1 
ATOM   1335 N N   . HIS A 1 178 ? -61.936 -22.873 28.924  1.00 35.54  ? 177 HIS A N   1 
ATOM   1336 C CA  . HIS A 1 178 ? -61.159 -22.884 30.149  1.00 33.67  ? 177 HIS A CA  1 
ATOM   1337 C C   . HIS A 1 178 ? -62.074 -23.144 31.344  1.00 35.59  ? 177 HIS A C   1 
ATOM   1338 O O   . HIS A 1 178 ? -63.303 -23.078 31.248  1.00 38.05  ? 177 HIS A O   1 
ATOM   1339 C CB  . HIS A 1 178 ? -60.411 -21.564 30.312  1.00 36.16  ? 177 HIS A CB  1 
ATOM   1340 C CG  . HIS A 1 178 ? -59.219 -21.651 31.211  1.00 43.13  ? 177 HIS A CG  1 
ATOM   1341 N ND1 . HIS A 1 178 ? -58.075 -22.335 30.863  1.00 40.75  ? 177 HIS A ND1 1 
ATOM   1342 C CD2 . HIS A 1 178 ? -58.992 -21.140 32.444  1.00 46.69  ? 177 HIS A CD2 1 
ATOM   1343 C CE1 . HIS A 1 178 ? -57.194 -22.243 31.843  1.00 43.68  ? 177 HIS A CE1 1 
ATOM   1344 N NE2 . HIS A 1 178 ? -57.727 -21.523 32.814  1.00 42.70  ? 177 HIS A NE2 1 
ATOM   1345 N N   . THR A 1 179 ? -61.463 -23.452 32.486  1.00 34.90  ? 178 THR A N   1 
ATOM   1346 C CA  . THR A 1 179 ? -62.237 -23.759 33.681  1.00 35.87  ? 178 THR A CA  1 
ATOM   1347 C C   . THR A 1 179 ? -62.994 -22.521 34.153  1.00 37.08  ? 178 THR A C   1 
ATOM   1348 O O   . THR A 1 179 ? -62.433 -21.423 34.226  1.00 38.37  ? 178 THR A O   1 
ATOM   1349 C CB  . THR A 1 179 ? -61.326 -24.296 34.786  1.00 44.65  ? 178 THR A CB  1 
ATOM   1350 O OG1 . THR A 1 179 ? -62.094 -24.529 35.974  1.00 54.08  ? 178 THR A OG1 1 
ATOM   1351 C CG2 . THR A 1 179 ? -60.188 -23.327 35.086  1.00 40.63  ? 178 THR A CG2 1 
ATOM   1352 N N   . GLY A 1 180 ? -64.283 -22.692 34.440  1.00 40.33  ? 179 GLY A N   1 
ATOM   1353 C CA  . GLY A 1 180 ? -65.101 -21.586 34.894  1.00 40.66  ? 179 GLY A CA  1 
ATOM   1354 C C   . GLY A 1 180 ? -65.538 -20.620 33.818  1.00 42.50  ? 179 GLY A C   1 
ATOM   1355 O O   . GLY A 1 180 ? -65.940 -19.498 34.138  1.00 48.41  ? 179 GLY A O   1 
ATOM   1356 N N   . VAL A 1 181 ? -65.472 -21.015 32.550  1.00 41.12  ? 180 VAL A N   1 
ATOM   1357 C CA  . VAL A 1 181 ? -65.886 -20.156 31.444  1.00 37.80  ? 180 VAL A CA  1 
ATOM   1358 C C   . VAL A 1 181 ? -67.339 -20.461 31.099  1.00 46.65  ? 180 VAL A C   1 
ATOM   1359 O O   . VAL A 1 181 ? -67.708 -21.638 30.983  1.00 38.10  ? 180 VAL A O   1 
ATOM   1360 C CB  . VAL A 1 181 ? -64.973 -20.343 30.221  1.00 37.71  ? 180 VAL A CB  1 
ATOM   1361 C CG1 . VAL A 1 181 ? -65.557 -19.644 29.005  1.00 36.67  ? 180 VAL A CG1 1 
ATOM   1362 C CG2 . VAL A 1 181 ? -63.582 -19.816 30.520  1.00 38.22  ? 180 VAL A CG2 1 
ATOM   1363 N N   . PRO A 1 182 ? -68.193 -19.448 30.946  1.00 43.47  ? 181 PRO A N   1 
ATOM   1364 C CA  . PRO A 1 182 ? -69.581 -19.706 30.547  1.00 44.12  ? 181 PRO A CA  1 
ATOM   1365 C C   . PRO A 1 182 ? -69.648 -20.464 29.231  1.00 42.18  ? 181 PRO A C   1 
ATOM   1366 O O   . PRO A 1 182 ? -68.825 -20.273 28.334  1.00 37.02  ? 181 PRO A O   1 
ATOM   1367 C CB  . PRO A 1 182 ? -70.178 -18.302 30.415  1.00 43.96  ? 181 PRO A CB  1 
ATOM   1368 C CG  . PRO A 1 182 ? -69.347 -17.458 31.318  1.00 47.17  ? 181 PRO A CG  1 
ATOM   1369 C CD  . PRO A 1 182 ? -67.955 -18.023 31.231  1.00 39.73  ? 181 PRO A CD  1 
ATOM   1370 N N   . ALA A 1 183 ? -70.652 -21.333 29.126  1.00 40.92  ? 182 ALA A N   1 
ATOM   1371 C CA  . ALA A 1 183 ? -70.804 -22.191 27.958  1.00 42.88  ? 182 ALA A CA  1 
ATOM   1372 C C   . ALA A 1 183 ? -71.192 -21.432 26.696  1.00 39.61  ? 182 ALA A C   1 
ATOM   1373 O O   . ALA A 1 183 ? -71.308 -22.057 25.637  1.00 38.18  ? 182 ALA A O   1 
ATOM   1374 C CB  . ALA A 1 183 ? -71.840 -23.274 28.248  1.00 45.84  ? 182 ALA A CB  1 
ATOM   1375 N N   . ARG A 1 184 ? -71.399 -20.118 26.772  1.00 45.19  ? 183 ARG A N   1 
ATOM   1376 C CA  . ARG A 1 184 ? -71.743 -19.350 25.583  1.00 40.98  ? 183 ARG A CA  1 
ATOM   1377 C C   . ARG A 1 184 ? -70.519 -18.953 24.767  1.00 38.99  ? 183 ARG A C   1 
ATOM   1378 O O   . ARG A 1 184 ? -70.655 -18.667 23.572  1.00 41.05  ? 183 ARG A O   1 
ATOM   1379 C CB  . ARG A 1 184 ? -72.545 -18.111 25.978  1.00 47.55  ? 183 ARG A CB  1 
ATOM   1380 C CG  . ARG A 1 184 ? -71.971 -17.347 27.149  1.00 45.90  ? 183 ARG A CG  1 
ATOM   1381 C CD  . ARG A 1 184 ? -72.969 -16.336 27.678  1.00 53.93  ? 183 ARG A CD  1 
ATOM   1382 N NE  . ARG A 1 184 ? -72.431 -15.616 28.826  1.00 44.34  ? 183 ARG A NE  1 
ATOM   1383 C CZ  . ARG A 1 184 ? -71.681 -14.525 28.730  1.00 35.13  ? 183 ARG A CZ  1 
ATOM   1384 N NH1 . ARG A 1 184 ? -71.389 -14.033 27.534  1.00 42.16  ? 183 ARG A NH1 1 
ATOM   1385 N NH2 . ARG A 1 184 ? -71.225 -13.930 29.823  1.00 45.09  ? 183 ARG A NH2 1 
ATOM   1386 N N   . PHE A 1 185 ? -69.336 -18.930 25.380  1.00 36.80  ? 184 PHE A N   1 
ATOM   1387 C CA  . PHE A 1 185 ? -68.091 -18.785 24.639  1.00 34.92  ? 184 PHE A CA  1 
ATOM   1388 C C   . PHE A 1 185 ? -67.694 -20.133 24.050  1.00 37.09  ? 184 PHE A C   1 
ATOM   1389 O O   . PHE A 1 185 ? -67.586 -21.124 24.778  1.00 41.00  ? 184 PHE A O   1 
ATOM   1390 C CB  . PHE A 1 185 ? -66.973 -18.275 25.550  1.00 33.88  ? 184 PHE A CB  1 
ATOM   1391 C CG  . PHE A 1 185 ? -67.278 -16.973 26.233  1.00 33.80  ? 184 PHE A CG  1 
ATOM   1392 C CD1 . PHE A 1 185 ? -66.893 -15.770 25.661  1.00 36.60  ? 184 PHE A CD1 1 
ATOM   1393 C CD2 . PHE A 1 185 ? -67.925 -16.950 27.457  1.00 45.58  ? 184 PHE A CD2 1 
ATOM   1394 C CE1 . PHE A 1 185 ? -67.165 -14.570 26.291  1.00 38.19  ? 184 PHE A CE1 1 
ATOM   1395 C CE2 . PHE A 1 185 ? -68.198 -15.752 28.091  1.00 43.34  ? 184 PHE A CE2 1 
ATOM   1396 C CZ  . PHE A 1 185 ? -67.817 -14.562 27.506  1.00 44.75  ? 184 PHE A CZ  1 
ATOM   1397 N N   . THR A 1 186 ? -67.477 -20.178 22.737  1.00 34.59  ? 185 THR A N   1 
ATOM   1398 C CA  . THR A 1 186 ? -67.029 -21.399 22.081  1.00 39.72  ? 185 THR A CA  1 
ATOM   1399 C C   . THR A 1 186 ? -65.864 -21.096 21.149  1.00 39.42  ? 185 THR A C   1 
ATOM   1400 O O   . THR A 1 186 ? -65.719 -19.978 20.649  1.00 35.88  ? 185 THR A O   1 
ATOM   1401 C CB  . THR A 1 186 ? -68.163 -22.085 21.293  1.00 39.04  ? 185 THR A CB  1 
ATOM   1402 O OG1 . THR A 1 186 ? -68.872 -21.115 20.512  1.00 40.08  ? 185 THR A OG1 1 
ATOM   1403 C CG2 . THR A 1 186 ? -69.129 -22.780 22.243  1.00 38.72  ? 185 THR A CG2 1 
ATOM   1404 N N   . GLY A 1 187 ? -65.031 -22.101 20.931  1.00 37.90  ? 186 GLY A N   1 
ATOM   1405 C CA  . GLY A 1 187 ? -63.878 -21.981 20.051  1.00 37.00  ? 186 GLY A CA  1 
ATOM   1406 C C   . GLY A 1 187 ? -63.932 -23.012 18.942  1.00 37.94  ? 186 GLY A C   1 
ATOM   1407 O O   . GLY A 1 187 ? -64.294 -24.168 19.173  1.00 39.12  ? 186 GLY A O   1 
ATOM   1408 N N   . SER A 1 188 ? -63.579 -22.582 17.734  1.00 34.10  ? 187 SER A N   1 
ATOM   1409 C CA  . SER A 1 188 ? -63.533 -23.446 16.566  1.00 40.38  ? 187 SER A CA  1 
ATOM   1410 C C   . SER A 1 188 ? -62.218 -23.219 15.843  1.00 37.31  ? 187 SER A C   1 
ATOM   1411 O O   . SER A 1 188 ? -61.624 -22.143 15.929  1.00 37.53  ? 187 SER A O   1 
ATOM   1412 C CB  . SER A 1 188 ? -64.697 -23.169 15.603  1.00 42.98  ? 187 SER A CB  1 
ATOM   1413 O OG  . SER A 1 188 ? -65.833 -22.679 16.290  1.00 49.17  ? 187 SER A OG  1 
ATOM   1414 N N   . GLY A 1 189 ? -61.767 -24.234 15.125  1.00 32.84  ? 188 GLY A N   1 
ATOM   1415 C CA  . GLY A 1 189 ? -60.627 -24.060 14.247  1.00 38.10  ? 188 GLY A CA  1 
ATOM   1416 C C   . GLY A 1 189 ? -59.508 -25.055 14.450  1.00 34.64  ? 188 GLY A C   1 
ATOM   1417 O O   . GLY A 1 189 ? -59.335 -25.630 15.529  1.00 34.14  ? 188 GLY A O   1 
ATOM   1418 N N   . SER A 1 190 ? -58.741 -25.265 13.386  1.00 37.98  ? 189 SER A N   1 
ATOM   1419 C CA  . SER A 1 190 ? -57.536 -26.079 13.405  1.00 37.28  ? 189 SER A CA  1 
ATOM   1420 C C   . SER A 1 190 ? -56.744 -25.760 12.146  1.00 42.17  ? 189 SER A C   1 
ATOM   1421 O O   . SER A 1 190 ? -57.301 -25.750 11.047  1.00 41.29  ? 189 SER A O   1 
ATOM   1422 C CB  . SER A 1 190 ? -57.869 -27.567 13.463  1.00 44.91  ? 189 SER A CB  1 
ATOM   1423 O OG  . SER A 1 190 ? -56.714 -28.329 13.158  1.00 42.15  ? 189 SER A OG  1 
ATOM   1424 N N   . GLY A 1 191 ? -55.464 -25.470 12.308  1.00 39.76  ? 190 GLY A N   1 
ATOM   1425 C CA  . GLY A 1 191 ? -54.639 -25.151 11.163  1.00 35.23  ? 190 GLY A CA  1 
ATOM   1426 C C   . GLY A 1 191 ? -54.291 -23.684 11.075  1.00 39.10  ? 190 GLY A C   1 
ATOM   1427 O O   . GLY A 1 191 ? -53.375 -23.220 11.759  1.00 32.32  ? 190 GLY A O   1 
ATOM   1428 N N   . THR A 1 192 ? -55.021 -22.943 10.242  1.00 40.48  ? 191 THR A N   1 
ATOM   1429 C CA  . THR A 1 192 ? -54.728 -21.540 9.994   1.00 38.71  ? 191 THR A CA  1 
ATOM   1430 C C   . THR A 1 192 ? -55.804 -20.581 10.476  1.00 38.79  ? 191 THR A C   1 
ATOM   1431 O O   . THR A 1 192 ? -55.471 -19.480 10.910  1.00 50.41  ? 191 THR A O   1 
ATOM   1432 C CB  . THR A 1 192 ? -54.494 -21.299 8.498   1.00 43.87  ? 191 THR A CB  1 
ATOM   1433 O OG1 . THR A 1 192 ? -55.435 -22.062 7.731   1.00 45.30  ? 191 THR A OG1 1 
ATOM   1434 C CG2 . THR A 1 192 ? -53.075 -21.687 8.107   1.00 46.50  ? 191 THR A CG2 1 
ATOM   1435 N N   . ASP A 1 193 ? -57.079 -20.958 10.406  1.00 35.46  ? 192 ASP A N   1 
ATOM   1436 C CA  . ASP A 1 193 ? -58.174 -20.078 10.791  1.00 40.74  ? 192 ASP A CA  1 
ATOM   1437 C C   . ASP A 1 193 ? -58.808 -20.562 12.086  1.00 42.00  ? 192 ASP A C   1 
ATOM   1438 O O   . ASP A 1 193 ? -59.016 -21.765 12.276  1.00 35.80  ? 192 ASP A O   1 
ATOM   1439 C CB  . ASP A 1 193 ? -59.236 -20.006 9.692   1.00 46.34  ? 192 ASP A CB  1 
ATOM   1440 C CG  . ASP A 1 193 ? -58.635 -19.936 8.307   1.00 58.44  ? 192 ASP A CG  1 
ATOM   1441 O OD1 . ASP A 1 193 ? -58.615 -20.973 7.612   1.00 60.62  ? 192 ASP A OD1 1 
ATOM   1442 O OD2 . ASP A 1 193 ? -58.168 -18.848 7.917   1.00 81.82  ? 192 ASP A OD2 1 
ATOM   1443 N N   . PHE A 1 194 ? -59.119 -19.620 12.977  1.00 39.14  ? 193 PHE A N   1 
ATOM   1444 C CA  . PHE A 1 194 ? -59.734 -19.940 14.255  1.00 32.34  ? 193 PHE A CA  1 
ATOM   1445 C C   . PHE A 1 194 ? -60.819 -18.918 14.553  1.00 36.56  ? 193 PHE A C   1 
ATOM   1446 O O   . PHE A 1 194 ? -60.730 -17.762 14.137  1.00 39.48  ? 193 PHE A O   1 
ATOM   1447 C CB  . PHE A 1 194 ? -58.694 -19.966 15.378  1.00 29.81  ? 193 PHE A CB  1 
ATOM   1448 C CG  . PHE A 1 194 ? -57.546 -20.894 15.111  1.00 31.75  ? 193 PHE A CG  1 
ATOM   1449 C CD1 . PHE A 1 194 ? -57.586 -22.207 15.543  1.00 41.41  ? 193 PHE A CD1 1 
ATOM   1450 C CD2 . PHE A 1 194 ? -56.430 -20.455 14.416  1.00 34.13  ? 193 PHE A CD2 1 
ATOM   1451 C CE1 . PHE A 1 194 ? -56.536 -23.062 15.295  1.00 33.70  ? 193 PHE A CE1 1 
ATOM   1452 C CE2 . PHE A 1 194 ? -55.377 -21.307 14.162  1.00 35.98  ? 193 PHE A CE2 1 
ATOM   1453 C CZ  . PHE A 1 194 ? -55.429 -22.612 14.603  1.00 30.88  ? 193 PHE A CZ  1 
ATOM   1454 N N   . THR A 1 195 ? -61.843 -19.352 15.287  1.00 33.95  ? 194 THR A N   1 
ATOM   1455 C CA  . THR A 1 195 ? -63.044 -18.548 15.487  1.00 35.83  ? 194 THR A CA  1 
ATOM   1456 C C   . THR A 1 195 ? -63.508 -18.647 16.932  1.00 36.18  ? 194 THR A C   1 
ATOM   1457 O O   . THR A 1 195 ? -63.882 -19.729 17.393  1.00 35.53  ? 194 THR A O   1 
ATOM   1458 C CB  . THR A 1 195 ? -64.165 -18.997 14.546  1.00 42.11  ? 194 THR A CB  1 
ATOM   1459 O OG1 . THR A 1 195 ? -63.667 -19.065 13.205  1.00 40.66  ? 194 THR A OG1 1 
ATOM   1460 C CG2 . THR A 1 195 ? -65.323 -18.018 14.601  1.00 39.95  ? 194 THR A CG2 1 
ATOM   1461 N N   . LEU A 1 196 ? -63.483 -17.520 17.636  1.00 31.06  ? 195 LEU A N   1 
ATOM   1462 C CA  . LEU A 1 196 ? -64.134 -17.382 18.929  1.00 31.30  ? 195 LEU A CA  1 
ATOM   1463 C C   . LEU A 1 196 ? -65.551 -16.865 18.717  1.00 32.38  ? 195 LEU A C   1 
ATOM   1464 O O   . LEU A 1 196 ? -65.752 -15.819 18.090  1.00 34.73  ? 195 LEU A O   1 
ATOM   1465 C CB  . LEU A 1 196 ? -63.349 -16.430 19.831  1.00 32.24  ? 195 LEU A CB  1 
ATOM   1466 C CG  . LEU A 1 196 ? -64.000 -16.052 21.161  1.00 31.78  ? 195 LEU A CG  1 
ATOM   1467 C CD1 . LEU A 1 196 ? -64.207 -17.286 22.021  1.00 30.19  ? 195 LEU A CD1 1 
ATOM   1468 C CD2 . LEU A 1 196 ? -63.164 -15.017 21.891  1.00 27.92  ? 195 LEU A CD2 1 
ATOM   1469 N N   . THR A 1 197 ? -66.533 -17.600 19.229  1.00 39.68  ? 196 THR A N   1 
ATOM   1470 C CA  . THR A 1 197 ? -67.937 -17.261 19.059  1.00 42.32  ? 196 THR A CA  1 
ATOM   1471 C C   . THR A 1 197 ? -68.553 -16.977 20.418  1.00 40.25  ? 196 THR A C   1 
ATOM   1472 O O   . THR A 1 197 ? -68.423 -17.785 21.345  1.00 40.61  ? 196 THR A O   1 
ATOM   1473 C CB  . THR A 1 197 ? -68.703 -18.390 18.367  1.00 41.71  ? 196 THR A CB  1 
ATOM   1474 O OG1 . THR A 1 197 ? -68.109 -18.660 17.093  1.00 40.21  ? 196 THR A OG1 1 
ATOM   1475 C CG2 . THR A 1 197 ? -70.155 -17.996 18.170  1.00 44.19  ? 196 THR A CG2 1 
ATOM   1476 N N   . ILE A 1 198 ? -69.222 -15.835 20.533  1.00 43.69  ? 197 ILE A N   1 
ATOM   1477 C CA  . ILE A 1 198 ? -69.939 -15.468 21.746  1.00 43.53  ? 197 ILE A CA  1 
ATOM   1478 C C   . ILE A 1 198 ? -71.424 -15.480 21.420  1.00 45.68  ? 197 ILE A C   1 
ATOM   1479 O O   . ILE A 1 198 ? -71.903 -14.662 20.622  1.00 43.09  ? 197 ILE A O   1 
ATOM   1480 C CB  . ILE A 1 198 ? -69.499 -14.102 22.289  1.00 44.64  ? 197 ILE A CB  1 
ATOM   1481 C CG1 . ILE A 1 198 ? -67.975 -14.040 22.415  1.00 43.21  ? 197 ILE A CG1 1 
ATOM   1482 C CG2 . ILE A 1 198 ? -70.150 -13.837 23.639  1.00 39.46  ? 197 ILE A CG2 1 
ATOM   1483 C CD1 . ILE A 1 198 ? -67.463 -12.737 22.984  1.00 40.21  ? 197 ILE A CD1 1 
ATOM   1484 N N   . ASN A 1 199 ? -72.147 -16.426 22.012  1.00 50.13  ? 198 ASN A N   1 
ATOM   1485 C CA  . ASN A 1 199 ? -73.600 -16.433 21.982  1.00 52.29  ? 198 ASN A CA  1 
ATOM   1486 C C   . ASN A 1 199 ? -74.127 -15.718 23.217  1.00 52.27  ? 198 ASN A C   1 
ATOM   1487 O O   . ASN A 1 199 ? -73.479 -15.701 24.267  1.00 50.00  ? 198 ASN A O   1 
ATOM   1488 C CB  . ASN A 1 199 ? -74.145 -17.863 21.940  1.00 51.19  ? 198 ASN A CB  1 
ATOM   1489 C CG  . ASN A 1 199 ? -73.753 -18.606 20.676  1.00 62.83  ? 198 ASN A CG  1 
ATOM   1490 O OD1 . ASN A 1 199 ? -74.542 -18.720 19.739  1.00 69.46  ? 198 ASN A OD1 1 
ATOM   1491 N ND2 . ASN A 1 199 ? -72.530 -19.122 20.646  1.00 77.18  ? 198 ASN A ND2 1 
ATOM   1492 N N   . ASN A 1 200 ? -75.307 -15.116 23.078  1.00 56.51  ? 199 ASN A N   1 
ATOM   1493 C CA  . ASN A 1 200 ? -75.988 -14.454 24.190  1.00 54.40  ? 199 ASN A CA  1 
ATOM   1494 C C   . ASN A 1 200 ? -75.068 -13.425 24.856  1.00 50.66  ? 199 ASN A C   1 
ATOM   1495 O O   . ASN A 1 200 ? -74.645 -13.567 26.005  1.00 45.83  ? 199 ASN A O   1 
ATOM   1496 C CB  . ASN A 1 200 ? -76.482 -15.491 25.205  1.00 56.84  ? 199 ASN A CB  1 
ATOM   1497 C CG  . ASN A 1 200 ? -77.589 -14.961 26.086  1.00 62.58  ? 199 ASN A CG  1 
ATOM   1498 O OD1 . ASN A 1 200 ? -78.361 -14.096 25.674  1.00 53.18  ? 199 ASN A OD1 1 
ATOM   1499 N ND2 . ASN A 1 200 ? -77.677 -15.478 27.307  1.00 48.42  ? 199 ASN A ND2 1 
ATOM   1500 N N   . VAL A 1 201 ? -74.755 -12.384 24.082  1.00 46.51  ? 200 VAL A N   1 
ATOM   1501 C CA  . VAL A 1 201 ? -73.850 -11.342 24.553  1.00 45.05  ? 200 VAL A CA  1 
ATOM   1502 C C   . VAL A 1 201 ? -74.445 -10.670 25.782  1.00 46.81  ? 200 VAL A C   1 
ATOM   1503 O O   . VAL A 1 201 ? -75.518 -10.057 25.719  1.00 45.53  ? 200 VAL A O   1 
ATOM   1504 C CB  . VAL A 1 201 ? -73.571 -10.327 23.440  1.00 46.77  ? 200 VAL A CB  1 
ATOM   1505 C CG1 . VAL A 1 201 ? -72.846 -9.114  24.002  1.00 45.17  ? 200 VAL A CG1 1 
ATOM   1506 C CG2 . VAL A 1 201 ? -72.753 -10.972 22.337  1.00 41.72  ? 200 VAL A CG2 1 
ATOM   1507 N N   . LYS A 1 202 ? -73.751 -10.785 26.908  1.00 38.16  ? 201 LYS A N   1 
ATOM   1508 C CA  . LYS A 1 202 ? -74.165 -10.147 28.147  1.00 41.36  ? 201 LYS A CA  1 
ATOM   1509 C C   . LYS A 1 202 ? -73.373 -8.861  28.366  1.00 48.58  ? 201 LYS A C   1 
ATOM   1510 O O   . LYS A 1 202 ? -72.391 -8.577  27.677  1.00 40.87  ? 201 LYS A O   1 
ATOM   1511 C CB  . LYS A 1 202 ? -73.991 -11.104 29.330  1.00 38.76  ? 201 LYS A CB  1 
ATOM   1512 C CG  . LYS A 1 202 ? -74.862 -12.348 29.245  1.00 50.79  ? 201 LYS A CG  1 
ATOM   1513 C CD  . LYS A 1 202 ? -74.852 -13.123 30.553  1.00 45.44  ? 201 LYS A CD  1 
ATOM   1514 C CE  . LYS A 1 202 ? -75.929 -14.197 30.567  1.00 47.87  ? 201 LYS A CE  1 
ATOM   1515 N NZ  . LYS A 1 202 ? -76.042 -14.840 31.905  1.00 44.40  ? 201 LYS A NZ  1 
ATOM   1516 N N   . SER A 1 203 ? -73.824 -8.074  29.347  1.00 47.40  ? 202 SER A N   1 
ATOM   1517 C CA  . SER A 1 203 ? -73.216 -6.769  29.589  1.00 46.47  ? 202 SER A CA  1 
ATOM   1518 C C   . SER A 1 203 ? -71.763 -6.902  30.025  1.00 47.28  ? 202 SER A C   1 
ATOM   1519 O O   . SER A 1 203 ? -70.915 -6.091  29.634  1.00 47.21  ? 202 SER A O   1 
ATOM   1520 C CB  . SER A 1 203 ? -74.015 -6.003  30.642  1.00 49.57  ? 202 SER A CB  1 
ATOM   1521 O OG  . SER A 1 203 ? -73.744 -6.504  31.941  1.00 56.25  ? 202 SER A OG  1 
ATOM   1522 N N   . GLU A 1 204 ? -71.454 -7.915  30.838  1.00 43.62  ? 203 GLU A N   1 
ATOM   1523 C CA  . GLU A 1 204 ? -70.089 -8.081  31.323  1.00 46.94  ? 203 GLU A CA  1 
ATOM   1524 C C   . GLU A 1 204 ? -69.121 -8.498  30.226  1.00 40.05  ? 203 GLU A C   1 
ATOM   1525 O O   . GLU A 1 204 ? -67.907 -8.455  30.448  1.00 42.14  ? 203 GLU A O   1 
ATOM   1526 C CB  . GLU A 1 204 ? -70.049 -9.102  32.466  1.00 45.57  ? 203 GLU A CB  1 
ATOM   1527 C CG  . GLU A 1 204 ? -70.488 -10.511 32.089  1.00 53.91  ? 203 GLU A CG  1 
ATOM   1528 C CD  . GLU A 1 204 ? -71.990 -10.711 32.181  1.00 54.46  ? 203 GLU A CD  1 
ATOM   1529 O OE1 . GLU A 1 204 ? -72.739 -9.720  32.049  1.00 45.74  ? 203 GLU A OE1 1 
ATOM   1530 O OE2 . GLU A 1 204 ? -72.422 -11.865 32.394  1.00 52.75  ? 203 GLU A OE2 1 
ATOM   1531 N N   . ASP A 1 205 ? -69.622 -8.890  29.053  1.00 39.73  ? 204 ASP A N   1 
ATOM   1532 C CA  . ASP A 1 205 ? -68.757 -9.263  27.942  1.00 44.01  ? 204 ASP A CA  1 
ATOM   1533 C C   . ASP A 1 205 ? -68.017 -8.076  27.346  1.00 44.59  ? 204 ASP A C   1 
ATOM   1534 O O   . ASP A 1 205 ? -67.124 -8.284  26.516  1.00 44.13  ? 204 ASP A O   1 
ATOM   1535 C CB  . ASP A 1 205 ? -69.572 -9.955  26.852  1.00 43.05  ? 204 ASP A CB  1 
ATOM   1536 C CG  . ASP A 1 205 ? -70.164 -11.269 27.315  1.00 37.85  ? 204 ASP A CG  1 
ATOM   1537 O OD1 . ASP A 1 205 ? -69.848 -11.701 28.446  1.00 48.36  ? 204 ASP A OD1 1 
ATOM   1538 O OD2 . ASP A 1 205 ? -70.945 -11.870 26.548  1.00 45.81  ? 204 ASP A OD2 1 
ATOM   1539 N N   . LEU A 1 206 ? -68.367 -6.850  27.733  1.00 44.30  ? 205 LEU A N   1 
ATOM   1540 C CA  . LEU A 1 206 ? -67.675 -5.668  27.237  1.00 35.88  ? 205 LEU A CA  1 
ATOM   1541 C C   . LEU A 1 206 ? -66.211 -5.715  27.651  1.00 35.03  ? 205 LEU A C   1 
ATOM   1542 O O   . LEU A 1 206 ? -65.878 -5.452  28.811  1.00 36.29  ? 205 LEU A O   1 
ATOM   1543 C CB  . LEU A 1 206 ? -68.347 -4.395  27.756  1.00 41.19  ? 205 LEU A CB  1 
ATOM   1544 C CG  . LEU A 1 206 ? -67.775 -3.067  27.259  1.00 44.00  ? 205 LEU A CG  1 
ATOM   1545 C CD1 . LEU A 1 206 ? -68.870 -2.210  26.641  1.00 44.14  ? 205 LEU A CD1 1 
ATOM   1546 C CD2 . LEU A 1 206 ? -67.085 -2.327  28.390  1.00 51.34  ? 205 LEU A CD2 1 
ATOM   1547 N N   . ALA A 1 207 ? -65.336 -6.056  26.713  1.00 40.81  ? 206 ALA A N   1 
ATOM   1548 C CA  . ALA A 1 207 ? -63.918 -6.251  27.001  1.00 39.28  ? 206 ALA A CA  1 
ATOM   1549 C C   . ALA A 1 207 ? -63.157 -6.266  25.678  1.00 33.45  ? 206 ALA A C   1 
ATOM   1550 O O   . ALA A 1 207 ? -63.701 -5.916  24.622  1.00 38.39  ? 206 ALA A O   1 
ATOM   1551 C CB  . ALA A 1 207 ? -63.688 -7.533  27.801  1.00 37.44  ? 206 ALA A CB  1 
ATOM   1552 N N   . ASP A 1 208 ? -61.893 -6.676  25.743  1.00 41.52  ? 207 ASP A N   1 
ATOM   1553 C CA  . ASP A 1 208 ? -61.006 -6.762  24.590  1.00 34.83  ? 207 ASP A CA  1 
ATOM   1554 C C   . ASP A 1 208 ? -60.568 -8.213  24.446  1.00 38.93  ? 207 ASP A C   1 
ATOM   1555 O O   . ASP A 1 208 ? -59.999 -8.784  25.379  1.00 38.67  ? 207 ASP A O   1 
ATOM   1556 C CB  . ASP A 1 208 ? -59.796 -5.842  24.771  1.00 37.85  ? 207 ASP A CB  1 
ATOM   1557 C CG  . ASP A 1 208 ? -59.515 -4.991  23.550  1.00 50.52  ? 207 ASP A CG  1 
ATOM   1558 O OD1 . ASP A 1 208 ? -60.250 -4.008  23.327  1.00 54.97  ? 207 ASP A OD1 1 
ATOM   1559 O OD2 . ASP A 1 208 ? -58.548 -5.300  22.821  1.00 64.68  ? 207 ASP A OD2 1 
ATOM   1560 N N   . TYR A 1 209 ? -60.841 -8.812  23.292  1.00 32.82  ? 208 TYR A N   1 
ATOM   1561 C CA  . TYR A 1 209 ? -60.571 -10.225 23.073  1.00 35.82  ? 208 TYR A CA  1 
ATOM   1562 C C   . TYR A 1 209 ? -59.397 -10.395 22.120  1.00 36.10  ? 208 TYR A C   1 
ATOM   1563 O O   . TYR A 1 209 ? -59.201 -9.589  21.206  1.00 34.61  ? 208 TYR A O   1 
ATOM   1564 C CB  . TYR A 1 209 ? -61.807 -10.938 22.513  1.00 33.41  ? 208 TYR A CB  1 
ATOM   1565 C CG  . TYR A 1 209 ? -63.022 -10.856 23.417  1.00 34.94  ? 208 TYR A CG  1 
ATOM   1566 C CD1 . TYR A 1 209 ? -63.347 -11.900 24.270  1.00 32.66  ? 208 TYR A CD1 1 
ATOM   1567 C CD2 . TYR A 1 209 ? -63.839 -9.731  23.419  1.00 37.39  ? 208 TYR A CD2 1 
ATOM   1568 C CE1 . TYR A 1 209 ? -64.452 -11.830 25.097  1.00 37.53  ? 208 TYR A CE1 1 
ATOM   1569 C CE2 . TYR A 1 209 ? -64.943 -9.652  24.242  1.00 41.08  ? 208 TYR A CE2 1 
ATOM   1570 C CZ  . TYR A 1 209 ? -65.245 -10.704 25.078  1.00 36.33  ? 208 TYR A CZ  1 
ATOM   1571 O OH  . TYR A 1 209 ? -66.345 -10.629 25.898  1.00 37.55  ? 208 TYR A OH  1 
ATOM   1572 N N   . PHE A 1 210 ? -58.611 -11.450 22.336  1.00 39.68  ? 209 PHE A N   1 
ATOM   1573 C CA  . PHE A 1 210 ? -57.481 -11.670 21.441  1.00 40.37  ? 209 PHE A CA  1 
ATOM   1574 C C   . PHE A 1 210 ? -57.034 -13.126 21.455  1.00 43.12  ? 209 PHE A C   1 
ATOM   1575 O O   . PHE A 1 210 ? -57.225 -13.849 22.437  1.00 32.72  ? 209 PHE A O   1 
ATOM   1576 C CB  . PHE A 1 210 ? -56.301 -10.754 21.791  1.00 39.42  ? 209 PHE A CB  1 
ATOM   1577 C CG  . PHE A 1 210 ? -56.024 -10.659 23.257  1.00 36.29  ? 209 PHE A CG  1 
ATOM   1578 C CD1 . PHE A 1 210 ? -55.294 -11.641 23.900  1.00 41.73  ? 209 PHE A CD1 1 
ATOM   1579 C CD2 . PHE A 1 210 ? -56.491 -9.583  23.993  1.00 44.51  ? 209 PHE A CD2 1 
ATOM   1580 C CE1 . PHE A 1 210 ? -55.036 -11.556 25.253  1.00 38.08  ? 209 PHE A CE1 1 
ATOM   1581 C CE2 . PHE A 1 210 ? -56.237 -9.490  25.345  1.00 39.20  ? 209 PHE A CE2 1 
ATOM   1582 C CZ  . PHE A 1 210 ? -55.510 -10.480 25.978  1.00 45.83  ? 209 PHE A CZ  1 
ATOM   1583 N N   . CYS A 1 211 ? -56.416 -13.529 20.347  1.00 30.08  ? 210 CYS A N   1 
ATOM   1584 C CA  . CYS A 1 211 ? -55.871 -14.863 20.141  1.00 30.05  ? 210 CYS A CA  1 
ATOM   1585 C C   . CYS A 1 211 ? -54.374 -14.882 20.427  1.00 35.08  ? 210 CYS A C   1 
ATOM   1586 O O   . CYS A 1 211 ? -53.710 -13.844 20.479  1.00 33.76  ? 210 CYS A O   1 
ATOM   1587 C CB  . CYS A 1 211 ? -56.125 -15.336 18.707  1.00 33.96  ? 210 CYS A CB  1 
ATOM   1588 S SG  . CYS A 1 211 ? -55.745 -14.078 17.461  1.00 39.72  ? 210 CYS A SG  1 
ATOM   1589 N N   . LEU A 1 212 ? -53.851 -16.088 20.619  1.00 27.81  ? 211 LEU A N   1 
ATOM   1590 C CA  . LEU A 1 212 ? -52.420 -16.284 20.813  1.00 26.17  ? 211 LEU A CA  1 
ATOM   1591 C C   . LEU A 1 212 ? -52.036 -17.645 20.260  1.00 35.90  ? 211 LEU A C   1 
ATOM   1592 O O   . LEU A 1 212 ? -52.688 -18.643 20.576  1.00 35.32  ? 211 LEU A O   1 
ATOM   1593 C CB  . LEU A 1 212 ? -52.043 -16.194 22.295  1.00 29.90  ? 211 LEU A CB  1 
ATOM   1594 C CG  . LEU A 1 212 ? -50.690 -16.798 22.676  1.00 30.69  ? 211 LEU A CG  1 
ATOM   1595 C CD1 . LEU A 1 212 ? -49.551 -15.909 22.213  1.00 29.79  ? 211 LEU A CD1 1 
ATOM   1596 C CD2 . LEU A 1 212 ? -50.613 -17.046 24.170  1.00 29.61  ? 211 LEU A CD2 1 
ATOM   1597 N N   . GLN A 1 213 ? -50.991 -17.687 19.439  1.00 30.67  ? 212 GLN A N   1 
ATOM   1598 C CA  . GLN A 1 213 ? -50.456 -18.961 18.980  1.00 28.53  ? 212 GLN A CA  1 
ATOM   1599 C C   . GLN A 1 213 ? -49.276 -19.361 19.856  1.00 30.55  ? 212 GLN A C   1 
ATOM   1600 O O   . GLN A 1 213 ? -48.511 -18.510 20.318  1.00 30.63  ? 212 GLN A O   1 
ATOM   1601 C CB  . GLN A 1 213 ? -50.040 -18.900 17.503  1.00 33.61  ? 212 GLN A CB  1 
ATOM   1602 C CG  . GLN A 1 213 ? -48.800 -18.074 17.181  1.00 31.75  ? 212 GLN A CG  1 
ATOM   1603 C CD  . GLN A 1 213 ? -47.503 -18.838 17.392  1.00 34.61  ? 212 GLN A CD  1 
ATOM   1604 O OE1 . GLN A 1 213 ? -47.492 -20.068 17.431  1.00 31.57  ? 212 GLN A OE1 1 
ATOM   1605 N NE2 . GLN A 1 213 ? -46.403 -18.106 17.543  1.00 32.16  ? 212 GLN A NE2 1 
ATOM   1606 N N   . HIS A 1 214 ? -49.152 -20.654 20.110  1.00 36.84  ? 213 HIS A N   1 
ATOM   1607 C CA  . HIS A 1 214 ? -48.007 -21.160 20.840  1.00 33.80  ? 213 HIS A CA  1 
ATOM   1608 C C   . HIS A 1 214 ? -47.463 -22.396 20.158  1.00 36.22  ? 213 HIS A C   1 
ATOM   1609 O O   . HIS A 1 214 ? -47.014 -23.336 20.812  1.00 33.22  ? 213 HIS A O   1 
ATOM   1610 C CB  . HIS A 1 214 ? -48.338 -21.414 22.316  1.00 36.82  ? 213 HIS A CB  1 
ATOM   1611 C CG  . HIS A 1 214 ? -49.435 -22.406 22.563  1.00 32.20  ? 213 HIS A CG  1 
ATOM   1612 N ND1 . HIS A 1 214 ? -49.209 -23.762 22.676  1.00 33.26  ? 213 HIS A ND1 1 
ATOM   1613 C CD2 . HIS A 1 214 ? -50.761 -22.228 22.773  1.00 40.12  ? 213 HIS A CD2 1 
ATOM   1614 C CE1 . HIS A 1 214 ? -50.352 -24.379 22.921  1.00 38.71  ? 213 HIS A CE1 1 
ATOM   1615 N NE2 . HIS A 1 214 ? -51.309 -23.471 22.978  1.00 34.47  ? 213 HIS A NE2 1 
ATOM   1616 N N   . TRP A 1 215 ? -47.493 -22.405 18.822  1.00 28.47  ? 214 TRP A N   1 
ATOM   1617 C CA  . TRP A 1 215 ? -46.864 -23.486 18.074  1.00 29.33  ? 214 TRP A CA  1 
ATOM   1618 C C   . TRP A 1 215 ? -45.349 -23.322 18.054  1.00 32.41  ? 214 TRP A C   1 
ATOM   1619 O O   . TRP A 1 215 ? -44.611 -24.215 18.484  1.00 29.66  ? 214 TRP A O   1 
ATOM   1620 C CB  . TRP A 1 215 ? -47.436 -23.546 16.655  1.00 29.09  ? 214 TRP A CB  1 
ATOM   1621 C CG  . TRP A 1 215 ? -46.923 -24.713 15.887  1.00 30.56  ? 214 TRP A CG  1 
ATOM   1622 C CD1 . TRP A 1 215 ? -46.161 -24.681 14.759  1.00 40.29  ? 214 TRP A CD1 1 
ATOM   1623 C CD2 . TRP A 1 215 ? -47.105 -26.096 16.211  1.00 32.23  ? 214 TRP A CD2 1 
ATOM   1624 N NE1 . TRP A 1 215 ? -45.866 -25.959 14.352  1.00 34.64  ? 214 TRP A NE1 1 
ATOM   1625 C CE2 . TRP A 1 215 ? -46.435 -26.845 15.229  1.00 40.88  ? 214 TRP A CE2 1 
ATOM   1626 C CE3 . TRP A 1 215 ? -47.775 -26.772 17.236  1.00 41.01  ? 214 TRP A CE3 1 
ATOM   1627 C CZ2 . TRP A 1 215 ? -46.413 -28.237 15.239  1.00 35.25  ? 214 TRP A CZ2 1 
ATOM   1628 C CZ3 . TRP A 1 215 ? -47.754 -28.157 17.246  1.00 39.18  ? 214 TRP A CZ3 1 
ATOM   1629 C CH2 . TRP A 1 215 ? -47.074 -28.874 16.256  1.00 36.47  ? 214 TRP A CH2 1 
ATOM   1630 N N   . ASN A 1 216 ? -44.869 -22.177 17.581  1.00 33.06  ? 215 ASN A N   1 
ATOM   1631 C CA  . ASN A 1 216 ? -43.444 -21.951 17.420  1.00 35.44  ? 215 ASN A CA  1 
ATOM   1632 C C   . ASN A 1 216 ? -43.051 -20.619 18.040  1.00 32.14  ? 215 ASN A C   1 
ATOM   1633 O O   . ASN A 1 216 ? -43.871 -19.705 18.161  1.00 35.89  ? 215 ASN A O   1 
ATOM   1634 C CB  . ASN A 1 216 ? -43.056 -21.984 15.942  1.00 34.60  ? 215 ASN A CB  1 
ATOM   1635 C CG  . ASN A 1 216 ? -41.613 -22.372 15.731  1.00 42.90  ? 215 ASN A CG  1 
ATOM   1636 O OD1 . ASN A 1 216 ? -40.949 -22.855 16.646  1.00 40.03  ? 215 ASN A OD1 1 
ATOM   1637 N ND2 . ASN A 1 216 ? -41.119 -22.169 14.517  1.00 48.17  ? 215 ASN A ND2 1 
ATOM   1638 N N   . TYR A 1 217 ? -41.783 -20.521 18.438  1.00 35.06  ? 216 TYR A N   1 
ATOM   1639 C CA  . TYR A 1 217 ? -41.272 -19.279 18.996  1.00 32.92  ? 216 TYR A CA  1 
ATOM   1640 C C   . TYR A 1 217 ? -41.072 -18.252 17.884  1.00 37.54  ? 216 TYR A C   1 
ATOM   1641 O O   . TYR A 1 217 ? -40.685 -18.610 16.768  1.00 37.51  ? 216 TYR A O   1 
ATOM   1642 C CB  . TYR A 1 217 ? -39.949 -19.515 19.724  1.00 37.89  ? 216 TYR A CB  1 
ATOM   1643 C CG  . TYR A 1 217 ? -40.004 -20.553 20.823  1.00 32.41  ? 216 TYR A CG  1 
ATOM   1644 C CD1 . TYR A 1 217 ? -39.489 -21.829 20.624  1.00 37.59  ? 216 TYR A CD1 1 
ATOM   1645 C CD2 . TYR A 1 217 ? -40.559 -20.257 22.061  1.00 39.61  ? 216 TYR A CD2 1 
ATOM   1646 C CE1 . TYR A 1 217 ? -39.529 -22.781 21.624  1.00 39.05  ? 216 TYR A CE1 1 
ATOM   1647 C CE2 . TYR A 1 217 ? -40.602 -21.204 23.068  1.00 34.08  ? 216 TYR A CE2 1 
ATOM   1648 C CZ  . TYR A 1 217 ? -40.086 -22.464 22.843  1.00 33.51  ? 216 TYR A CZ  1 
ATOM   1649 O OH  . TYR A 1 217 ? -40.126 -23.410 23.842  1.00 36.59  ? 216 TYR A OH  1 
ATOM   1650 N N   . PRO A 1 218 ? -41.331 -16.965 18.151  1.00 35.54  ? 217 PRO A N   1 
ATOM   1651 C CA  . PRO A 1 218 ? -41.867 -16.483 19.425  1.00 36.29  ? 217 PRO A CA  1 
ATOM   1652 C C   . PRO A 1 218 ? -43.384 -16.618 19.489  1.00 34.98  ? 217 PRO A C   1 
ATOM   1653 O O   . PRO A 1 218 ? -44.037 -16.688 18.447  1.00 34.41  ? 217 PRO A O   1 
ATOM   1654 C CB  . PRO A 1 218 ? -41.451 -15.014 19.436  1.00 36.57  ? 217 PRO A CB  1 
ATOM   1655 C CG  . PRO A 1 218 ? -41.482 -14.632 17.997  1.00 35.04  ? 217 PRO A CG  1 
ATOM   1656 C CD  . PRO A 1 218 ? -41.038 -15.855 17.227  1.00 37.11  ? 217 PRO A CD  1 
ATOM   1657 N N   . LEU A 1 219 ? -43.938 -16.667 20.695  1.00 26.20  ? 218 LEU A N   1 
ATOM   1658 C CA  . LEU A 1 219 ? -45.384 -16.604 20.829  1.00 27.15  ? 218 LEU A CA  1 
ATOM   1659 C C   . LEU A 1 219 ? -45.871 -15.245 20.341  1.00 28.10  ? 218 LEU A C   1 
ATOM   1660 O O   . LEU A 1 219 ? -45.291 -14.208 20.674  1.00 30.27  ? 218 LEU A O   1 
ATOM   1661 C CB  . LEU A 1 219 ? -45.805 -16.842 22.280  1.00 22.80  ? 218 LEU A CB  1 
ATOM   1662 C CG  . LEU A 1 219 ? -45.257 -18.069 23.016  1.00 38.62  ? 218 LEU A CG  1 
ATOM   1663 C CD1 . LEU A 1 219 ? -46.123 -18.378 24.226  1.00 35.44  ? 218 LEU A CD1 1 
ATOM   1664 C CD2 . LEU A 1 219 ? -45.155 -19.279 22.106  1.00 31.57  ? 218 LEU A CD2 1 
ATOM   1665 N N   . THR A 1 220 ? -46.921 -15.252 19.531  1.00 31.58  ? 219 THR A N   1 
ATOM   1666 C CA  . THR A 1 220 ? -47.434 -14.028 18.937  1.00 29.02  ? 219 THR A CA  1 
ATOM   1667 C C   . THR A 1 220 ? -48.933 -13.930 19.175  1.00 34.99  ? 219 THR A C   1 
ATOM   1668 O O   . THR A 1 220 ? -49.648 -14.934 19.113  1.00 28.50  ? 219 THR A O   1 
ATOM   1669 C CB  . THR A 1 220 ? -47.131 -13.968 17.431  1.00 29.76  ? 219 THR A CB  1 
ATOM   1670 O OG1 . THR A 1 220 ? -47.624 -15.150 16.791  1.00 28.66  ? 219 THR A OG1 1 
ATOM   1671 C CG2 . THR A 1 220 ? -45.633 -13.859 17.192  1.00 36.19  ? 219 THR A CG2 1 
ATOM   1672 N N   . PHE A 1 221 ? -49.399 -12.716 19.451  1.00 31.63  ? 220 PHE A N   1 
ATOM   1673 C CA  . PHE A 1 221 ? -50.803 -12.446 19.721  1.00 35.96  ? 220 PHE A CA  1 
ATOM   1674 C C   . PHE A 1 221 ? -51.481 -11.828 18.505  1.00 33.07  ? 220 PHE A C   1 
ATOM   1675 O O   . PHE A 1 221 ? -50.831 -11.326 17.584  1.00 33.12  ? 220 PHE A O   1 
ATOM   1676 C CB  . PHE A 1 221 ? -50.961 -11.502 20.918  1.00 27.69  ? 220 PHE A CB  1 
ATOM   1677 C CG  . PHE A 1 221 ? -50.561 -12.106 22.232  1.00 30.10  ? 220 PHE A CG  1 
ATOM   1678 C CD1 . PHE A 1 221 ? -51.506 -12.698 23.051  1.00 30.99  ? 220 PHE A CD1 1 
ATOM   1679 C CD2 . PHE A 1 221 ? -49.243 -12.067 22.653  1.00 29.40  ? 220 PHE A CD2 1 
ATOM   1680 C CE1 . PHE A 1 221 ? -51.141 -13.251 24.261  1.00 35.24  ? 220 PHE A CE1 1 
ATOM   1681 C CE2 . PHE A 1 221 ? -48.872 -12.617 23.863  1.00 30.11  ? 220 PHE A CE2 1 
ATOM   1682 C CZ  . PHE A 1 221 ? -49.822 -13.210 24.668  1.00 32.00  ? 220 PHE A CZ  1 
ATOM   1683 N N   . GLY A 1 222 ? -52.812 -11.872 18.519  1.00 34.52  ? 221 GLY A N   1 
ATOM   1684 C CA  . GLY A 1 222 ? -53.581 -11.101 17.573  1.00 37.30  ? 221 GLY A CA  1 
ATOM   1685 C C   . GLY A 1 222 ? -53.656 -9.642  17.974  1.00 40.37  ? 221 GLY A C   1 
ATOM   1686 O O   . GLY A 1 222 ? -53.447 -9.277  19.131  1.00 34.80  ? 221 GLY A O   1 
ATOM   1687 N N   . SER A 1 223 ? -53.969 -8.792  16.993  1.00 40.05  ? 222 SER A N   1 
ATOM   1688 C CA  . SER A 1 223 ? -53.978 -7.354  17.235  1.00 46.21  ? 222 SER A CA  1 
ATOM   1689 C C   . SER A 1 223 ? -55.043 -6.934  18.241  1.00 42.71  ? 222 SER A C   1 
ATOM   1690 O O   . SER A 1 223 ? -54.957 -5.829  18.788  1.00 40.35  ? 222 SER A O   1 
ATOM   1691 C CB  . SER A 1 223 ? -54.174 -6.602  15.917  1.00 49.56  ? 222 SER A CB  1 
ATOM   1692 O OG  . SER A 1 223 ? -55.352 -7.030  15.256  1.00 53.64  ? 222 SER A OG  1 
ATOM   1693 N N   . GLY A 1 224 ? -56.037 -7.780  18.495  1.00 40.53  ? 223 GLY A N   1 
ATOM   1694 C CA  . GLY A 1 224 ? -57.072 -7.498  19.467  1.00 41.74  ? 223 GLY A CA  1 
ATOM   1695 C C   . GLY A 1 224 ? -58.399 -7.156  18.811  1.00 47.48  ? 223 GLY A C   1 
ATOM   1696 O O   . GLY A 1 224 ? -58.503 -6.925  17.604  1.00 42.57  ? 223 GLY A O   1 
ATOM   1697 N N   . THR A 1 225 ? -59.435 -7.126  19.647  1.00 44.16  ? 224 THR A N   1 
ATOM   1698 C CA  . THR A 1 225 ? -60.791 -6.808  19.205  1.00 38.18  ? 224 THR A CA  1 
ATOM   1699 C C   . THR A 1 225 ? -61.568 -6.256  20.388  1.00 43.56  ? 224 THR A C   1 
ATOM   1700 O O   . THR A 1 225 ? -61.753 -6.962  21.384  1.00 40.89  ? 224 THR A O   1 
ATOM   1701 C CB  . THR A 1 225 ? -61.499 -8.042  18.644  1.00 45.38  ? 224 THR A CB  1 
ATOM   1702 O OG1 . THR A 1 225 ? -60.915 -8.403  17.387  1.00 38.92  ? 224 THR A OG1 1 
ATOM   1703 C CG2 . THR A 1 225 ? -62.982 -7.762  18.461  1.00 41.02  ? 224 THR A CG2 1 
ATOM   1704 N N   . LYS A 1 226 ? -62.024 -5.009  20.283  1.00 35.61  ? 225 LYS A N   1 
ATOM   1705 C CA  . LYS A 1 226 ? -62.831 -4.401  21.333  1.00 41.72  ? 225 LYS A CA  1 
ATOM   1706 C C   . LYS A 1 226 ? -64.308 -4.651  21.064  1.00 39.74  ? 225 LYS A C   1 
ATOM   1707 O O   . LYS A 1 226 ? -64.778 -4.495  19.932  1.00 44.79  ? 225 LYS A O   1 
ATOM   1708 C CB  . LYS A 1 226 ? -62.566 -2.898  21.447  1.00 46.18  ? 225 LYS A CB  1 
ATOM   1709 C CG  . LYS A 1 226 ? -63.564 -2.186  22.359  1.00 72.82  ? 225 LYS A CG  1 
ATOM   1710 C CD  . LYS A 1 226 ? -63.009 -0.907  22.955  1.00 85.01  ? 225 LYS A CD  1 
ATOM   1711 C CE  . LYS A 1 226 ? -64.114 0.116   23.156  1.00 84.39  ? 225 LYS A CE  1 
ATOM   1712 N NZ  . LYS A 1 226 ? -63.604 1.398   23.715  1.00 65.80  ? 225 LYS A NZ  1 
ATOM   1713 N N   . LEU A 1 227 ? -65.031 -5.038  22.109  1.00 45.82  ? 226 LEU A N   1 
ATOM   1714 C CA  . LEU A 1 227 ? -66.464 -5.296  22.037  1.00 45.09  ? 226 LEU A CA  1 
ATOM   1715 C C   . LEU A 1 227 ? -67.190 -4.159  22.745  1.00 45.55  ? 226 LEU A C   1 
ATOM   1716 O O   . LEU A 1 227 ? -67.046 -3.986  23.961  1.00 48.87  ? 226 LEU A O   1 
ATOM   1717 C CB  . LEU A 1 227 ? -66.808 -6.641  22.672  1.00 46.78  ? 226 LEU A CB  1 
ATOM   1718 C CG  . LEU A 1 227 ? -68.276 -7.066  22.585  1.00 46.96  ? 226 LEU A CG  1 
ATOM   1719 C CD1 . LEU A 1 227 ? -68.555 -7.756  21.259  1.00 40.91  ? 226 LEU A CD1 1 
ATOM   1720 C CD2 . LEU A 1 227 ? -68.662 -7.957  23.752  1.00 49.94  ? 226 LEU A CD2 1 
ATOM   1721 N N   . GLU A 1 228 ? -67.965 -3.387  21.988  1.00 43.35  ? 227 GLU A N   1 
ATOM   1722 C CA  . GLU A 1 228 ? -68.848 -2.380  22.552  1.00 47.37  ? 227 GLU A CA  1 
ATOM   1723 C C   . GLU A 1 228 ? -70.281 -2.893  22.532  1.00 51.29  ? 227 GLU A C   1 
ATOM   1724 O O   . GLU A 1 228 ? -70.652 -3.717  21.693  1.00 45.63  ? 227 GLU A O   1 
ATOM   1725 C CB  . GLU A 1 228 ? -68.757 -1.062  21.782  1.00 53.40  ? 227 GLU A CB  1 
ATOM   1726 C CG  . GLU A 1 228 ? -67.415 -0.363  21.891  1.00 59.75  ? 227 GLU A CG  1 
ATOM   1727 C CD  . GLU A 1 228 ? -67.415 0.996   21.223  1.00 61.32  ? 227 GLU A CD  1 
ATOM   1728 O OE1 . GLU A 1 228 ? -68.513 1.548   20.998  1.00 75.92  ? 227 GLU A OE1 1 
ATOM   1729 O OE2 . GLU A 1 228 ? -66.316 1.507   20.918  1.00 73.69  ? 227 GLU A OE2 1 
ATOM   1730 N N   . ILE A 1 229 ? -71.082 -2.399  23.470  1.00 51.72  ? 228 ILE A N   1 
ATOM   1731 C CA  . ILE A 1 229 ? -72.472 -2.810  23.615  1.00 53.42  ? 228 ILE A CA  1 
ATOM   1732 C C   . ILE A 1 229 ? -73.355 -1.576  23.501  1.00 54.08  ? 228 ILE A C   1 
ATOM   1733 O O   . ILE A 1 229 ? -73.116 -0.569  24.179  1.00 51.77  ? 228 ILE A O   1 
ATOM   1734 C CB  . ILE A 1 229 ? -72.709 -3.545  24.947  1.00 51.30  ? 228 ILE A CB  1 
ATOM   1735 C CG1 . ILE A 1 229 ? -71.776 -4.756  25.050  1.00 55.69  ? 228 ILE A CG1 1 
ATOM   1736 C CG2 . ILE A 1 229 ? -74.162 -3.979  25.063  1.00 52.86  ? 228 ILE A CG2 1 
ATOM   1737 C CD1 . ILE A 1 229 ? -71.838 -5.474  26.380  1.00 55.55  ? 228 ILE A CD1 1 
ATOM   1738 N N   . LYS A 1 230 ? -74.368 -1.655  22.642  1.00 58.30  ? 229 LYS A N   1 
ATOM   1739 C CA  . LYS A 1 230 ? -75.288 -0.545  22.406  1.00 60.20  ? 229 LYS A CA  1 
ATOM   1740 C C   . LYS A 1 230 ? -76.237 -0.327  23.583  1.00 57.74  ? 229 LYS A C   1 
ATOM   1741 O O   . LYS A 1 230 ? -76.588 -1.266  24.297  1.00 61.90  ? 229 LYS A O   1 
ATOM   1742 C CB  . LYS A 1 230 ? -76.086 -0.792  21.122  1.00 64.25  ? 229 LYS A CB  1 
ATOM   1743 C CG  . LYS A 1 230 ? -77.415 -0.055  21.040  1.00 72.34  ? 229 LYS A CG  1 
ATOM   1744 C CD  . LYS A 1 230 ? -78.581 -1.035  21.051  1.00 82.44  ? 229 LYS A CD  1 
ATOM   1745 C CE  . LYS A 1 230 ? -79.867 -0.384  20.568  1.00 85.14  ? 229 LYS A CE  1 
ATOM   1746 N NZ  . LYS A 1 230 ? -80.969 -1.378  20.445  1.00 85.70  ? 229 LYS A NZ  1 
HETATM 1747 C C   . ACT B 2 .   ? -65.340 -14.887 32.096  0.00 44.12  ? 301 ACT A C   1 
HETATM 1748 O O   . ACT B 2 .   ? -66.340 -14.754 31.386  0.00 44.12  ? 301 ACT A O   1 
HETATM 1749 O OXT . ACT B 2 .   ? -64.772 -15.944 32.383  0.00 44.12  ? 301 ACT A OXT 1 
HETATM 1750 C CH3 . ACT B 2 .   ? -64.730 -13.593 32.720  0.00 44.12  ? 301 ACT A CH3 1 
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