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{"sheet":"Sheet1","index":0,"n_rows":22,"n_cols":22,"rows_kept":22,"merged":[[1,0,3,0],[1,1,1,21],[2,1,2,3],[2,4,2,6],[2,7,2,9],[2,10,2,12],[2,13,2,15],[2,16,2,18],[2,19,2,21]],"flags":["formulas_cached_only"]}
["Supplementary Table 1. Association between all topics and polygenic risk score (PRS) tranches of autism spectrum disorder (ASD). Seven tranches of SNPs (1×10−2, 1×10−3, 1×10−4, 1×10−5, 1×10−6, 1×10−7, 5×10−8) are labelled as S2–S8."]
["Trait","ASD PRS Trenches"]
[null,"S2",null,null,"S3",null,null,"S4",null,null,"S5",null,null,"S6",null,null,"S7",null,null,"S8"]
[null,"Beta","Standard Error","P","Beta","Standard Error","P","Beta","Standard Error","P","Beta","Standard Error","P","Beta","Standard Error","P","Beta","Standard Error","P","Beta","Standard Error","P"]
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["Topic 2",{"v":516.264541760763,"d":"516.265"},{"v":481.226796589106,"d":"481.227"},{"v":0.283871141697063,"d":"0.284"},{"v":1895.45120703185,"d":"1895.451"},{"v":1205.21737068799,"d":"1205.217"},{"v":0.116415941747506,"d":"0.116"},{"v":176.934006325804,"d":"176.934"},{"v":2408.60968876046,"d":"2408.610"},{"v":0.941470088676726,"d":"0.941"},{"v":2002.12167443173,"d":"2002.122"},{"v":4702.41025709284,"d":"4702.410"},{"v":0.670461211659542,"d":"0.670"},{"v":7072.6868750306,"d":"7072.687"},{"v":8515.63148774285,"d":"8515.631"},{"v":0.406619996518823,"d":"0.407"},{"v":8866.43691802669,"d":"8866.437"},{"v":14849.2917247948,"d":"14849.292"},{"v":0.550712666497578,"d":"0.551"},{"v":8866.43691802669,"d":"8866.437"},{"v":14849.2917247948,"d":"14849.292"},{"v":0.550712666497578,"d":"0.551"}]
["Topic 3",{"v":-107.756522092789,"d":"-107.757"},{"v":488.01507877141,"d":"488.015"},{"v":0.825333305394569,"d":"0.825"},{"v":879.714074082689,"d":"879.714"},{"v":1223.2510015193,"d":"1223.251"},{"v":0.47237586470238,"d":"0.472"},{"v":1230.12402487698,"d":"1230.124"},{"v":2439.31112014147,"d":"2439.311"},{"v":0.614277324914246,"d":"0.614"},{"v":-3009.80212118572,"d":"-3009.802"},{"v":4762.49575726863,"d":"4762.496"},{"v":0.527687067286584,"d":"0.528"},{"v":-1797.71242051896,"d":"-1797.712"},{"v":8631.85079724957,"d":"8631.851"},{"v":0.83510635918016,"d":"0.835"},{"v":10043.4515522047,"d":"10043.452"},{"v":15040.9542852674,"d":"15040.954"},{"v":0.504605617961722,"d":"0.505"},{"v":10043.4515522047,"d":"10043.452"},{"v":15040.9542852674,"d":"15040.954"},{"v":0.504605617961722,"d":"0.505"}]
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["Topic 6",{"v":-926.046547088453,"d":"-926.047"},{"v":485.405022498705,"d":"485.405"},{"v":0.0569886563883572,"d":"0.057"},{"v":-2571.96790481181,"d":"-2571.968"},{"v":1216.27676312103,"d":"1216.277"},{"v":0.0349532979553691,"d":"0.035"},{"v":-5953.03063488993,"d":"-5953.031"},{"v":2421.01747094025,"d":"2421.017"},{"v":0.0142722230347351,"d":"0.014"},{"v":-14839.3121003722,"d":"-14839.312"},{"v":4709.53704917999,"d":"4709.537"},{"v":0.00172460144872336,"d":"0.002"},{"v":-23831.0766398818,"d":"-23831.077"},{"v":8550.87768131608,"d":"8550.878"},{"v":0.00552141574909602,"d":"0.006"},{"v":-26259.6114550588,"d":"-26259.611"},{"v":14974.7600371497,"d":"14974.760"},{"v":0.0801095846453562,"d":"0.080"},{"v":-26259.6114550588,"d":"-26259.611"},{"v":14974.7600371497,"d":"14974.760"},{"v":0.0801095846453562,"d":"0.080"}]
["Topic 7",{"v":-827.746942240331,"d":"-827.747"},{"v":487.130390471586,"d":"487.130"},{"v":0.0898940147378596,"d":"0.090"},{"v":-806.447467675023,"d":"-806.447"},{"v":1224.57520757422,"d":"1224.575"},{"v":0.510484281193182,"d":"0.510"},{"v":-1012.80789721998,"d":"-1012.808"},{"v":2441.94891476111,"d":"2441.949"},{"v":0.678498883365426,"d":"0.678"},{"v":-3383.63763673991,"d":"-3383.638"},{"v":4766.76135232684,"d":"4766.761"},{"v":0.478132322530446,"d":"0.478"},{"v":-404.405791352994,"d":"-404.406"},{"v":8640.8322212218,"d":"8640.832"},{"v":0.9626898353956,"d":"0.963"},{"v":21910.0611480718,"d":"21910.061"},{"v":15030.9460641186,"d":"15030.946"},{"v":0.145557357682732,"d":"0.146"},{"v":21910.0611480718,"d":"21910.061"},{"v":15030.9460641186,"d":"15030.946"},{"v":0.145557357682732,"d":"0.146"}]
["Topic 8",{"v":-92.3686842042158,"d":"-92.369"},{"v":486.588295188312,"d":"486.588"},{"v":0.849519525311523,"d":"0.850"},{"v":510.457831530396,"d":"510.458"},{"v":1220.07382796132,"d":"1220.074"},{"v":0.675845872149083,"d":"0.676"},{"v":-1420.26870686763,"d":"-1420.269"},{"v":2431.93907989884,"d":"2431.939"},{"v":0.559477609189213,"d":"0.559"},{"v":-3337.32451131534,"d":"-3337.325"},{"v":4748.06555217058,"d":"4748.066"},{"v":0.48245515667811,"d":"0.482"},{"v":-7775.52795150945,"d":"-7775.528"},{"v":8599.89115048091,"d":"8599.891"},{"v":0.366352608723233,"d":"0.366"},{"v":-23380.8813164539,"d":"-23380.881"},{"v":14967.1730782131,"d":"14967.173"},{"v":0.118882949375669,"d":"0.119"},{"v":-23380.8813164539,"d":"-23380.881"},{"v":14967.1730782131,"d":"14967.173"},{"v":0.118882949375669,"d":"0.119"}]
["Topic 9",{"v":-608.856167757563,"d":"-608.856"},{"v":483.37382118749,"d":"483.374"},{"v":0.208398954081544,"d":"0.208"},{"v":274.520065950059,"d":"274.520"},{"v":1214.02984146741,"d":"1214.030"},{"v":0.821197613005814,"d":"0.821"},{"v":-61.8878388466586,"d":"-61.888"},{"v":2420.41239136895,"d":"2420.412"},{"v":0.979611149340578,"d":"0.980"},{"v":3187.72232184574,"d":"3187.722"},{"v":4724.14454300517,"d":"4724.145"},{"v":0.500130407103091,"d":"0.500"},{"v":12285.8921236194,"d":"12285.892"},{"v":8545.64552945663,"d":"8545.646"},{"v":0.151147057946143,"d":"0.151"},{"v":18464.4830551821,"d":"18464.483"},{"v":14904.5524910782,"d":"14904.552"},{"v":0.215979381199214,"d":"0.216"},{"v":18464.4830551821,"d":"18464.483"},{"v":14904.5524910782,"d":"14904.552"},{"v":0.215979381199214,"d":"0.216"}]
["Topic 10",{"v":451.947003395433,"d":"451.947"},{"v":484.660986308866,"d":"484.661"},{"v":0.351524887583318,"d":"0.352"},{"v":977.912395912412,"d":"977.912"},{"v":1215.6775884574,"d":"1215.678"},{"v":0.421535891780572,"d":"0.422"},{"v":1209.98759411673,"d":"1209.988"},{"v":2424.53413305034,"d":"2424.534"},{"v":0.617955423388587,"d":"0.618"},{"v":-1775.13175237887,"d":"-1775.132"},{"v":4734.83802904335,"d":"4734.838"},{"v":0.70788642265649,"d":"0.708"},{"v":-1103.28436184837,"d":"-1103.284"},{"v":8579.7444497624,"d":"8579.744"},{"v":0.897732092048558,"d":"0.898"},{"v":-6761.16759027659,"d":"-6761.168"},{"v":14953.3464404146,"d":"14953.346"},{"v":0.651355268599405,"d":"0.651"},{"v":-6761.16759027659,"d":"-6761.168"},{"v":14953.3464404146,"d":"14953.346"},{"v":0.651355268599405,"d":"0.651"}]
["Topic 11",{"v":-2.23355499085943,"d":"-2.234"},{"v":486.42202904655,"d":"486.422"},{"v":0.996338103251336,"d":"0.996"},{"v":-1768.34024589068,"d":"-1768.340"},{"v":1217.27458365931,"d":"1217.275"},{"v":0.146929341581343,"d":"0.147"},{"v":-1271.89241767707,"d":"-1271.892"},{"v":2431.18377133252,"d":"2431.184"},{"v":0.601094919604138,"d":"0.601"},{"v":-3994.96011252545,"d":"-3994.960"},{"v":4745.26148048863,"d":"4745.261"},{"v":0.400252924182896,"d":"0.400"},{"v":-4473.57030129702,"d":"-4473.570"},{"v":8601.31509169179,"d":"8601.315"},{"v":0.603220570024489,"d":"0.603"},{"v":-22476.8100319003,"d":"-22476.810"},{"v":14964.2500518957,"d":"14964.250"},{"v":0.13371586600154,"d":"0.134"},{"v":-22476.8100319003,"d":"-22476.810"},{"v":14964.2500518957,"d":"14964.250"},{"v":0.13371586600154,"d":"0.134"}]
["Topic 12",{"v":619.119746333792,"d":"619.120"},{"v":479.903254823827,"d":"479.903"},{"v":0.197611202520922,"d":"0.198"},{"v":1045.1055632701,"d":"1045.106"},{"v":1204.56637192608,"d":"1204.566"},{"v":0.386016259457061,"d":"0.386"},{"v":-629.205414494037,"d":"-629.205"},{"v":2403.05706363264,"d":"2403.057"},{"v":0.793555529226688,"d":"0.794"},{"v":-809.413047806293,"d":"-809.413"},{"v":4692.57081939023,"d":"4692.571"},{"v":0.86312312491058,"d":"0.863"},{"v":-6112.5405565206,"d":"-6112.541"},{"v":8497.98835589383,"d":"8497.988"},{"v":0.472294663294392,"d":"0.472"},{"v":-9016.87980883376,"d":"-9016.880"},{"v":14815.7852838143,"d":"14815.785"},{"v":0.543064655495055,"d":"0.543"},{"v":-9016.87980883376,"d":"-9016.880"},{"v":14815.7852838143,"d":"14815.785"},{"v":0.543064655495055,"d":"0.543"}]
["Topic 13",{"v":380.204064670755,"d":"380.204"},{"v":487.376835293426,"d":"487.377"},{"v":0.435697255131828,"d":"0.436"},{"v":494.217156166066,"d":"494.217"},{"v":1222.76044544461,"d":"1222.760"},{"v":0.686251046986218,"d":"0.686"},{"v":2168.88239067892,"d":"2168.882"},{"v":2436.17346736271,"d":"2436.173"},{"v":0.373739875028675,"d":"0.374"},{"v":4604.5060567305,"d":"4604.506"},{"v":4756.37305895529,"d":"4756.373"},{"v":0.333474226864339,"d":"0.333"},{"v":2744.83564570923,"d":"2744.836"},{"v":8624.86060869285,"d":"8624.861"},{"v":0.750429704459437,"d":"0.750"},{"v":-9580.92772507095,"d":"-9580.928"},{"v":15030.2291724561,"d":"15030.229"},{"v":0.524125786552142,"d":"0.524"},{"v":-9580.92772507095,"d":"-9580.928"},{"v":15030.2291724561,"d":"15030.229"},{"v":0.524125786552142,"d":"0.524"}]
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["Topic 15",{"v":-76.8921430406325,"d":"-76.892"},{"v":487.348654180752,"d":"487.349"},{"v":0.874696268945751,"d":"0.875"},{"v":-864.136692286728,"d":"-864.137"},{"v":1221.57193568923,"d":"1221.572"},{"v":0.479647223126765,"d":"0.480"},{"v":-3091.68840462487,"d":"-3091.688"},{"v":2432.63524506285,"d":"2432.635"},{"v":0.204344026691741,"d":"0.204"},{"v":-3470.81027976759,"d":"-3470.810"},{"v":4755.24963272003,"d":"4755.250"},{"v":0.465797051411318,"d":"0.466"},{"v":-6263.42713286893,"d":"-6263.427"},{"v":8615.70546702363,"d":"8615.705"},{"v":0.467577713249028,"d":"0.468"},{"v":4930.33631432707,"d":"4930.336"},{"v":15025.1059620224,"d":"15025.106"},{"v":0.742942457415066,"d":"0.743"},{"v":4930.33631432707,"d":"4930.336"},{"v":15025.1059620224,"d":"15025.106"},{"v":0.742942457415066,"d":"0.743"}]
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["Topic 17",{"v":-61.6429176469335,"d":"-61.643"},{"v":487.21065186481,"d":"487.211"},{"v":0.89936920977113,"d":"0.899"},{"v":-2462.13160272224,"d":"-2462.132"},{"v":1216.88063258347,"d":"1216.881"},{"v":0.0435691288272133,"d":"0.044"},{"v":-5080.26046991143,"d":"-5080.260"},{"v":2425.271228582,"d":"2425.271"},{"v":0.0366956750846408,"d":"0.037"},{"v":-6614.39967723395,"d":"-6614.400"},{"v":4747.22572283942,"d":"4747.226"},{"v":0.16413873265986,"d":"0.164"},{"v":-3244.90269578765,"d":"-3244.903"},{"v":8616.49876359499,"d":"8616.499"},{"v":0.706635794549466,"d":"0.707"},{"v":5410.35867443956,"d":"5410.359"},{"v":15020.3892090556,"d":"15020.389"},{"v":0.718848050916951,"d":"0.719"},{"v":5410.35867443956,"d":"5410.359"},{"v":15020.3892090556,"d":"15020.389"},{"v":0.718848050916951,"d":"0.719"}]
["Topic 18",{"v":250.365454007386,"d":"250.365"},{"v":485.85915047049,"d":"485.859"},{"v":0.606566575480871,"d":"0.607"},{"v":259.092435903574,"d":"259.092"},{"v":1218.68069099,"d":"1218.681"},{"v":0.831724510900293,"d":"0.832"},{"v":1084.66226934418,"d":"1084.662"},{"v":2429.19066823034,"d":"2429.191"},{"v":0.655419766018576,"d":"0.655"},{"v":-2164.3883468196,"d":"-2164.388"},{"v":4743.37863282203,"d":"4743.379"},{"v":0.648373538658092,"d":"0.648"},{"v":-2217.43788618138,"d":"-2217.438"},{"v":8595.37090159271,"d":"8595.371"},{"v":0.796527489815702,"d":"0.797"},{"v":8351.23345697867,"d":"8351.233"},{"v":14979.7429094568,"d":"14979.743"},{"v":0.577432645383269,"d":"0.577"},{"v":8351.23345697867,"d":"8351.233"},{"v":14979.7429094568,"d":"14979.743"},{"v":0.577432645383269,"d":"0.577"}]