ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count BP GO:0007033 vacuole organization 10/55 217/18614 0.000000000697315149903218 0.000000813681407074586 0.000000580229124564141 TASL/SCARB2/ABCA1/ATP6V0A1/RUFY4/SH3GLB1/C9orf72/LRRK2/RALB/IRGM 10 BP GO:0016241 regulation of macroautophagy 9/55 159/18614 0.000000000876339695287653 0.000000813681407074586 0.000000580229124564141 ATP6V0A1/SPTLC2/RUFY4/SH3GLB1/C9orf72/LRRK2/RALB/IRGM/NOD2 9 BP GO:0016239 positive regulation of macroautophagy 7/55 75/18614 0.00000000225084810791118 0.00000139327497879702 0.000000993532252544656 SPTLC2/RUFY4/SH3GLB1/C9orf72/RALB/IRGM/NOD2 7 BP GO:0010508 positive regulation of autophagy 8/55 146/18614 0.0000000105339920058196 0.00000489040578870176 0.00000348730577455818 SPTLC2/RUFY4/SH3GLB1/C9orf72/LRRK2/RALB/IRGM/NOD2 8 BP GO:0016236 macroautophagy 10/55 322/18614 0.0000000306428377818097 0.0000113807499521641 0.00000811551366937192 ATP6V0A1/SPTLC2/RUFY4/SH3GLB1/C9orf72/LRRK2/LAMP2/RALB/IRGM/NOD2 10 BP GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 4/55 18/18614 0.000000202394088254604 0.000059971748371794 0.000042765331435375 JAK2/STAT1/LRRK2/NOD2 4 BP GO:0009615 response to virus 10/55 408/18614 0.000000278167957195381 0.000059971748371794 0.000042765331435375 JAK2/APOBEC3A/ZBP1/STAT1/GBP1/APOBEC3B/ADAR/CXCL10/MYD88/IRGM 10 BP GO:0071222 cellular response to lipopolysaccharide 8/55 224/18614 0.000000290536171052459 0.000059971748371794 0.000042765331435375 JAK2/ABCA1/CXCL10/MYD88/CD6/CXCL11/IRGM/NOD2 8 BP GO:0014075 response to amine 5/55 48/18614 0.000000290654677084623 0.000059971748371794 0.000042765331435375 JAK2/MYD88/CDK1/RGS2/DBH 5 BP GO:0044088 regulation of vacuole organization 5/55 50/18614 0.000000358041041509436 0.0000642131442581498 0.0000457898339011719 SCARB2/SH3GLB1/C9orf72/LRRK2/RALB 5 BP GO:0071219 cellular response to molecule of bacterial origin 8/55 237/18614 0.000000446172350455838 0.0000642131442581498 0.0000457898339011719 JAK2/ABCA1/CXCL10/MYD88/CD6/CXCL11/IRGM/NOD2 8 BP GO:0051767 nitric-oxide synthase biosynthetic process 4/55 22/18614 0.000000479601799687471 0.0000642131442581498 0.0000457898339011719 JAK2/STAT1/LRRK2/NOD2 4 BP GO:0051769 regulation of nitric-oxide synthase biosynthetic process 4/55 22/18614 0.000000479601799687471 0.0000642131442581498 0.0000457898339011719 JAK2/STAT1/LRRK2/NOD2 4 BP GO:0140888 interferon-mediated signaling pathway 6/55 100/18614 0.000000484105557142756 0.0000642131442581498 0.0000457898339011719 JAK2/ZBP1/STAT1/ADAR/MYD88/IRGM 6 BP GO:0010506 regulation of autophagy 9/55 348/18614 0.000000750189187241436 0.0000928734213804897 0.0000662272278982264 ATP6V0A1/SPTLC2/RUFY4/SH3GLB1/C9orf72/LRRK2/RALB/IRGM/NOD2 9 BP GO:0000045 autophagosome assembly 6/55 109/18614 0.000000805830811601863 0.0000935267385715412 0.0000666931026970489 RUFY4/SH3GLB1/C9orf72/LRRK2/RALB/IRGM 6 BP GO:0071216 cellular response to biotic stimulus 8/55 264/18614 0.00000100745257973506 0.000107913321638998 0.0000769520497814018 JAK2/ABCA1/CXCL10/MYD88/CD6/CXCL11/IRGM/NOD2 8 BP GO:1905037 autophagosome organization 6/55 115/18614 0.00000110461014121168 0.000107913321638998 0.0000769520497814018 RUFY4/SH3GLB1/C9orf72/LRRK2/RALB/IRGM 6 BP GO:0042832 defense response to protozoan 4/55 27/18614 0.00000113810470286627 0.000107913321638998 0.0000769520497814018 MYD88/GBP4/BATF2/NKG7 4 BP GO:0071346 cellular response to type II interferon 6/55 116/18614 0.00000116223286633278 0.000107913321638998 0.0000769520497814018 JAK2/STAT1/GBP1/GBP4/IRGM/GBP5 6 BP GO:0001562 response to protozoan 4/55 29/18614 0.00000153349642272043 0.000129441038954175 0.0000923032775015457 MYD88/GBP4/BATF2/NKG7 4 BP GO:1900017 positive regulation of cytokine production involved in inflammatory response 4/55 29/18614 0.00000153349642272043 0.000129441038954175 0.0000923032775015457 MYD88/CD6/NOD2/GBP5 4 BP GO:0051607 defense response to virus 8/55 303/18614 0.00000281646127992873 0.000223308273767426 0.00015923918510298 APOBEC3A/ZBP1/STAT1/GBP1/APOBEC3B/ADAR/CXCL10/MYD88 8 BP GO:0140546 defense response to symbiont 8/55 304/18614 0.00000288605200345624 0.000223308273767426 0.00015923918510298 APOBEC3A/ZBP1/STAT1/GBP1/APOBEC3B/ADAR/CXCL10/MYD88 8 BP GO:0034341 response to type II interferon 6/55 139/18614 0.00000333917202467963 0.000248033697993203 0.000176870669770399 JAK2/STAT1/GBP1/GBP4/IRGM/GBP5 6 BP GO:0031349 positive regulation of defense response 9/55 441/18614 0.00000524441120690873 0.000362458170739946 0.000258465764697362 JAK2/ZBP1/TASL/MYD88/LRRK2/IRGM/NOD2/GBP5/NKG7 9 BP GO:0015838 amino-acid betaine transport 3/55 12/18614 0.00000526998955841601 0.000362458170739946 0.000258465764697362 SLC22A1/SLC22A4/SLC22A16 3 BP GO:0032496 response to lipopolysaccharide 8/55 345/18614 0.00000731883258284934 0.000485395432369687 0.000346131255234003 JAK2/ABCA1/CXCL10/MYD88/CD6/CXCL11/IRGM/NOD2 8 BP GO:2000785 regulation of autophagosome assembly 4/55 44/18614 0.00000848141052465261 0.000543102736009651 0.000387281830853466 SH3GLB1/C9orf72/LRRK2/RALB 4 BP GO:0002237 response to molecule of bacterial origin 8/55 366/18614 0.0000112502145877997 0.000692955742960177 0.000494140704953605 JAK2/ABCA1/CXCL10/MYD88/CD6/CXCL11/IRGM/NOD2 8 BP GO:0007040 lysosome organization 5/55 101/18614 0.0000119410790386245 0.000692955742960177 0.000494140704953605 TASL/SCARB2/ABCA1/ATP6V0A1/LRRK2 5 BP GO:0080171 lytic vacuole organization 5/55 101/18614 0.0000119410790386245 0.000692955742960177 0.000494140704953605 TASL/SCARB2/ABCA1/ATP6V0A1/LRRK2 5 BP GO:0019221 cytokine-mediated signaling pathway 9/55 492/18614 0.0000126261637391695 0.000710508668595083 0.000506657543345302 JAK2/ZBP1/STAT1/ADAR/CXCL10/CXCR6/MYD88/CXCL11/IRGM 9 BP GO:0016553 base conversion or substitution editing 3/55 19/18614 0.0000228739456915656 0.00124932109262463 0.000890879990092557 APOBEC3A/APOBEC3B/ADAR 3 BP GO:0043691 reverse cholesterol transport 3/55 20/18614 0.0000268542205751735 0.0014248082173742 0.00101601833033288 ABCA1/CETP/APOA2 3 BP GO:0045471 response to ethanol 5/55 126/18614 0.0000348154636249235 0.00179171851390937 0.00127765886715868 CHRNB2/MYD88/CDK1/RGS2/DBH 5 BP GO:0032731 positive regulation of interleukin-1 beta production 4/55 63/18614 0.0000356992918764926 0.00179171851390937 0.00127765886715868 JAK2/MYD88/NOD2/GBP5 4 BP GO:0031331 positive regulation of cellular catabolic process 8/55 450/18614 0.0000492851618416745 0.00240848804052604 0.00171747184478744 SPTLC2/RUFY4/SH3GLB1/C9orf72/LRRK2/RALB/IRGM/NOD2 8 BP GO:0060333 type II interferon-mediated signaling pathway 3/55 25/18614 0.0000536153129200329 0.00255291374596156 0.00182046055744673 JAK2/STAT1/IRGM 3 BP GO:0002831 regulation of response to biotic stimulus 8/55 463/18614 0.0000602064432599412 0.00279508412834277 0.00199315014792121 ZBP1/STAT1/TASL/ADAR/MYD88/IRGM/NOD2/GBP5 8 BP GO:0032732 positive regulation of interleukin-1 production 4/55 74/18614 0.0000673192785258795 0.00300214350065363 0.00214080238291657 JAK2/MYD88/NOD2/GBP5 4 BP GO:0032740 positive regulation of interleukin-17 production 3/55 27/18614 0.0000678998530034747 0.00300214350065363 0.00214080238291657 JAK2/MYD88/NOD2 3 BP GO:0060337 type I interferon-mediated signaling pathway 4/55 76/18614 0.0000747349391028303 0.00320285440432236 0.0022839275802157 ZBP1/STAT1/ADAR/MYD88 4 BP GO:0015697 quaternary ammonium group transport 3/55 28/18614 0.000075888849644687 0.00320285440432236 0.0022839275802157 SLC22A1/SLC22A4/SLC22A16 3 BP GO:0071357 cellular response to type I interferon 4/55 77/18614 0.0000786577888827236 0.00324594475456039 0.00231465493367172 ZBP1/STAT1/ADAR/MYD88 4 BP GO:0002534 cytokine production involved in inflammatory response 4/55 78/18614 0.0000827284428118232 0.00326786787767977 0.00233028812182703 MYD88/CD6/NOD2/GBP5 4 BP GO:1900015 regulation of cytokine production involved in inflammatory response 4/55 78/18614 0.0000827284428118232 0.00326786787767977 0.00233028812182703 MYD88/CD6/NOD2/GBP5 4 BP GO:0035751 regulation of lysosomal lumen pH 3/55 29/18614 0.0000844683134779908 0.00326786787767977 0.00233028812182703 TASL/ATP6V0A1/LRRK2 3 BP GO:0001819 positive regulation of cytokine production 8/55 489/18614 0.0000881646133423219 0.00334125891789167 0.00238262263339723 JAK2/STAT1/MYD88/CD6/LRRK2/APOA2/NOD2/GBP5 8 BP GO:0072665 protein localization to vacuole 4/55 81/18614 0.0000958610889646408 0.00356028084414676 0.00253880526142144 SCARB2/GBP1/SH3GLB1/LAMP2 4 BP GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 4/55 82/18614 0.000100556937138609 0.00366145553463523 0.00261095205202002 CXCL10/CXCL11/GNLY/NOD2 4 BP GO:0034340 response to type I interferon 4/55 83/18614 0.000105417694957759 0.00376462806801074 0.00268452348698099 ZBP1/STAT1/ADAR/MYD88 4 BP GO:0045088 regulation of innate immune response 7/55 373/18614 0.000108769730530867 0.00381104508671358 0.00271762305874539 ZBP1/TASL/ADAR/MYD88/IRGM/NOD2/GBP5 7 BP GO:0098586 cellular response to virus 4/55 85/18614 0.000115647919801807 0.00392382853246071 0.00279804795161159 JAK2/ADAR/CXCL10/IRGM 4 BP GO:0002696 positive regulation of leukocyte activation 7/55 377/18614 0.000116214630740624 0.00392382853246071 0.00279804795161159 JAK2/CHRNB2/MYD88/CD6/LRRK2/HLA-DOA/NOD2 7 BP GO:0050867 positive regulation of cell activation 7/55 394/18614 0.000152639250885256 0.00506162658739142 0.00360940183484308 JAK2/CHRNB2/MYD88/CD6/LRRK2/HLA-DOA/NOD2 7 BP GO:0002443 leukocyte mediated immunity 7/55 401/18614 0.000170106494146349 0.00554189051982054 0.00395187386216265 GZMM/MYD88/HLA-C/HLA-DOA/NOD2/NKG7/DBH 7 BP GO:0002753 cytosolic pattern recognition receptor signaling pathway 4/55 95/18614 0.000177901001023115 0.00569589929137802 0.00406169617580905 TASL/MYD88/IRGM/NOD2 4 BP GO:0010742 macrophage derived foam cell differentiation 3/55 38/18614 0.000191375689581235 0.00602346873817549 0.00429528309532906 STAT1/ABCA1/CETP 3 BP GO:0090077 foam cell differentiation 3/55 39/18614 0.000206890709039673 0.00640326744477787 0.00456611424512119 STAT1/ABCA1/CETP 3 BP GO:0002532 production of molecular mediator involved in inflammatory response 4/55 102/18614 0.000233868541118181 0.00711957181731905 0.00507690465447234 MYD88/CD6/NOD2/GBP5 4 BP GO:0016032 viral process 7/55 426/18614 0.000246215084870242 0.00719794826521196 0.00513279421683907 APOBEC3A/STAT1/SCARB2/APOBEC3B/ADAR/CXCR6/CDK1 7 BP GO:0002449 lymphocyte mediated immunity 6/55 300/18614 0.000248908265202459 0.00719794826521196 0.00513279421683907 GZMM/MYD88/HLA-C/HLA-DOA/NOD2/NKG7 6 BP GO:0045089 positive regulation of innate immune response 6/55 300/18614 0.000248908265202459 0.00719794826521196 0.00513279421683907 ZBP1/TASL/MYD88/IRGM/NOD2/GBP5 6 BP GO:0015914 phospholipid transport 4/55 104/18614 0.000251947569864716 0.00719794826521196 0.00513279421683907 SCARB2/ABCA1/CETP/APOA2 4 BP GO:0032760 positive regulation of tumor necrosis factor production 4/55 105/18614 0.000261354314341069 0.00735356002623281 0.00524375960831045 JAK2/MYD88/LRRK2/NOD2 4 BP GO:0001906 cell killing 5/55 197/18614 0.000285780530717413 0.00792081262003336 0.00564826249241956 GZMM/MYD88/HLA-C/GNLY/NKG7 5 BP GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 4/55 109/18614 0.00030152014941643 0.00812519602308399 0.00579400651704201 JAK2/MYD88/LRRK2/NOD2 4 BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6/55 311/18614 0.000301905506512006 0.00812519602308399 0.00579400651704201 JAK2/GZMM/MYD88/HLA-C/HLA-DOA/NOD2 6 BP GO:0032611 interleukin-1 beta production 4/55 112/18614 0.000334420016646168 0.00873455625811359 0.00622853599337182 JAK2/MYD88/NOD2/GBP5 4 BP GO:0032651 regulation of interleukin-1 beta production 4/55 112/18614 0.000334420016646168 0.00873455625811359 0.00622853599337182 JAK2/MYD88/NOD2/GBP5 4 BP GO:0071827 plasma lipoprotein particle organization 3/55 46/18614 0.000338658077859008 0.00873455625811359 0.00622853599337182 ABCA1/CETP/APOA2 3 BP GO:0019058 viral life cycle 6/55 320/18614 0.000351548345953554 0.00894281203336643 0.00637704137288494 APOBEC3A/SCARB2/APOBEC3B/ADAR/CXCR6/CDK1 6 BP GO:0019882 antigen processing and presentation 4/55 114/18614 0.000357734139636885 0.00897719320683373 0.006401558288239 TAP1/HLA-C/HLA-DOA/NOD2 4 BP GO:0032620 interleukin-17 production 3/55 48/18614 0.000384256418213476 0.00938900221871611 0.00669521570793009 JAK2/MYD88/NOD2 3 BP GO:0032660 regulation of interleukin-17 production 3/55 48/18614 0.000384256418213476 0.00938900221871611 0.00669521570793009 JAK2/MYD88/NOD2 3 BP GO:0002833 positive regulation of response to biotic stimulus 6/55 327/18614 0.000394414936935265 0.00939010946011265 0.00669600527212636 ZBP1/TASL/MYD88/IRGM/NOD2/GBP5 6 BP GO:0051251 positive regulation of lymphocyte activation 6/55 327/18614 0.000394414936935265 0.00939010946011265 0.00669600527212636 JAK2/CHRNB2/MYD88/CD6/HLA-DOA/NOD2 6 BP GO:0071825 protein-lipid complex subunit organization 3/55 49/18614 0.000408462705734016 0.00948144055685085 0.00676113268175516 ABCA1/CETP/APOA2 3 BP GO:0072337 modified amino acid transport 3/55 49/18614 0.000408462705734016 0.00948144055685085 0.00676113268175516 SLC22A1/SLC22A4/SLC22A16 3 BP GO:0002269 leukocyte activation involved in inflammatory response 3/55 50/18614 0.000433628361815891 0.00994133170237172 0.00708907705216882 JAK2/MYD88/LRRK2 3 BP GO:0120009 intermembrane lipid transfer 3/55 51/18614 0.000459769157699257 0.0104120893396039 0.00742477022317927 ABCA1/CETP/APOA2 3 BP GO:0031667 response to nutrient levels 7/55 477/18614 0.000486602873208683 0.0108870064523919 0.00776342947998128 STAT1/CXCL10/SH3GLB1/LRRK2/LAMP2/RALB/NOD2 7 BP GO:0019730 antimicrobial humoral response 4/55 126/18614 0.000522723263253653 0.0113284269479529 0.00807820259078011 CXCL10/CXCL11/GNLY/NOD2 4 BP GO:1990266 neutrophil migration 4/55 128/18614 0.00055470767544972 0.0113284269479529 0.00807820259078011 CXCL10/MYD88/CXCL11/NOD2 4 BP GO:0006216 cytidine catabolic process 2/55 12/18614 0.000555135623189937 0.0113284269479529 0.00807820259078011 APOBEC3A/APOBEC3B 2 BP GO:0009972 cytidine deamination 2/55 12/18614 0.000555135623189937 0.0113284269479529 0.00807820259078011 APOBEC3A/APOBEC3B 2 BP GO:0016554 cytidine to uridine editing 2/55 12/18614 0.000555135623189937 0.0113284269479529 0.00807820259078011 APOBEC3A/APOBEC3B 2 BP GO:0034370 triglyceride-rich lipoprotein particle remodeling 2/55 12/18614 0.000555135623189937 0.0113284269479529 0.00807820259078011 CETP/APOA2 2 BP GO:0034372 very-low-density lipoprotein particle remodeling 2/55 12/18614 0.000555135623189937 0.0113284269479529 0.00807820259078011 CETP/APOA2 2 BP GO:0046087 cytidine metabolic process 2/55 12/18614 0.000555135623189937 0.0113284269479529 0.00807820259078011 APOBEC3A/APOBEC3B 2 BP GO:0019079 viral genome replication 4/55 129/18614 0.00057121115075815 0.0115297729017161 0.00822178063677062 APOBEC3A/APOBEC3B/ADAR/CXCR6 4 BP GO:0030218 erythrocyte differentiation 4/55 130/18614 0.000588060948850464 0.0117422492689819 0.00837329568368856 JAK2/STAT1/ADAR/RHAG 4 BP GO:0032612 interleukin-1 production 4/55 131/18614 0.000605261184453521 0.0118059468570793 0.00841871787898179 JAK2/MYD88/NOD2/GBP5 4 BP GO:0032652 regulation of interleukin-1 production 4/55 131/18614 0.000605261184453521 0.0118059468570793 0.00841871787898179 JAK2/MYD88/NOD2/GBP5 4 BP GO:0002218 activation of innate immune response 5/55 233/18614 0.000615254504826382 0.0118059468570793 0.00841871787898179 ZBP1/TASL/MYD88/IRGM/NOD2 5 BP GO:0007041 lysosomal transport 4/55 132/18614 0.000622815977745521 0.0118059468570793 0.00841871787898179 SCARB2/C9orf72/LRRK2/LAMP2 4 BP GO:0010745 negative regulation of macrophage derived foam cell differentiation 2/55 13/18614 0.000654826346946238 0.0118059468570793 0.00841871787898179 ABCA1/CETP 2 BP GO:0032494 response to peptidoglycan 2/55 13/18614 0.000654826346946238 0.0118059468570793 0.00841871787898179 MYD88/NOD2 2 BP GO:0032621 interleukin-18 production 2/55 13/18614 0.000654826346946238 0.0118059468570793 0.00841871787898179 NOD2/GBP5 2 BP GO:0032661 regulation of interleukin-18 production 2/55 13/18614 0.000654826346946238 0.0118059468570793 0.00841871787898179 NOD2/GBP5 2 BP GO:0034380 high-density lipoprotein particle assembly 2/55 13/18614 0.000654826346946238 0.0118059468570793 0.00841871787898179 ABCA1/APOA2 2 BP GO:0045006 DNA deamination 2/55 13/18614 0.000654826346946238 0.0118059468570793 0.00841871787898179 APOBEC3A/APOBEC3B 2 BP GO:0015695 organic cation transport 3/55 60/18614 0.000741443297391279 0.0128726718438536 0.0091793901763273 SLC22A1/SLC22A4/SLC22A16 3 BP GO:0001909 leukocyte mediated cytotoxicity 4/55 139/18614 0.000755974255873127 0.0128726718438536 0.0091793901763273 GZMM/MYD88/HLA-C/NKG7 4 BP GO:0034101 erythrocyte homeostasis 4/55 139/18614 0.000755974255873127 0.0128726718438536 0.0091793901763273 JAK2/STAT1/ADAR/RHAG 4 BP GO:0042157 lipoprotein metabolic process 4/55 139/18614 0.000755974255873127 0.0128726718438536 0.0091793901763273 ABCA1/APOL6/APOA2/IRGM 4 BP GO:0033700 phospholipid efflux 2/55 14/18614 0.000762516910513675 0.0128726718438536 0.0091793901763273 ABCA1/APOA2 2 BP GO:0046131 pyrimidine ribonucleoside metabolic process 2/55 14/18614 0.000762516910513675 0.0128726718438536 0.0091793901763273 APOBEC3A/APOBEC3B 2 BP GO:0046133 pyrimidine ribonucleoside catabolic process 2/55 14/18614 0.000762516910513675 0.0128726718438536 0.0091793901763273 APOBEC3A/APOBEC3B 2 BP GO:0033002 muscle cell proliferation 5/55 249/18614 0.000829837817925957 0.0138829624134099 0.00989981958227457 JAK2/STAT1/MYD88/CDK1/DBH 5 BP GO:0032757 positive regulation of interleukin-8 production 3/55 63/18614 0.000855049927842805 0.0141770331786079 0.0101095188837053 MYD88/APOA2/NOD2 3 BP GO:0097305 response to alcohol 5/55 252/18614 0.000875599433508508 0.0143892756462416 0.0102608671388328 CHRNB2/MYD88/CDK1/RGS2/DBH 5 BP GO:0050671 positive regulation of lymphocyte proliferation 4/55 145/18614 0.000885175917112108 0.0144190498076946 0.0102820988340446 JAK2/CHRNB2/MYD88/CD6 4 BP GO:0032946 positive regulation of mononuclear cell proliferation 4/55 148/18614 0.000955291405977567 0.0152473717657045 0.0108727680079678 JAK2/CHRNB2/MYD88/CD6 4 BP GO:0015748 organophosphate ester transport 4/55 149/18614 0.000979508012432158 0.0152473717657045 0.0108727680079678 SCARB2/ABCA1/CETP/APOA2 4 BP GO:0034374 low-density lipoprotein particle remodeling 2/55 16/18614 0.001001712092308 0.0152473717657045 0.0108727680079678 CETP/APOA2 2 BP GO:0034375 high-density lipoprotein particle remodeling 2/55 16/18614 0.001001712092308 0.0152473717657045 0.0108727680079678 CETP/APOA2 2 BP GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 2/55 16/18614 0.001001712092308 0.0152473717657045 0.0108727680079678 APOBEC3A/APOBEC3B 2 BP GO:0046135 pyrimidine nucleoside catabolic process 2/55 16/18614 0.001001712092308 0.0152473717657045 0.0108727680079678 APOBEC3A/APOBEC3B 2 BP GO:0055091 phospholipid homeostasis 2/55 16/18614 0.001001712092308 0.0152473717657045 0.0108727680079678 ABCA1/CETP 2 BP GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 2/55 16/18614 0.001001712092308 0.0152473717657045 0.0108727680079678 IRGM/NOD2 2 BP GO:0009620 response to fungus 3/55 67/18614 0.00102291548938771 0.0154435289739267 0.0110126460047047 ZBP1/MYD88/GNLY 3 BP GO:0050729 positive regulation of inflammatory response 4/55 154/18614 0.00110711461776321 0.0165799342353733 0.0118230066990333 JAK2/ZBP1/LRRK2/NKG7 4 BP GO:0060192 negative regulation of lipase activity 2/55 17/18614 0.00113312446694846 0.0168336970809863 0.012003962774073 RGS2/APOA2 2 BP GO:0097530 granulocyte migration 4/55 156/18614 0.0011612794810791 0.0171150475901896 0.012204591371742 CXCL10/MYD88/CXCL11/NOD2 4 BP GO:0033344 cholesterol efflux 3/55 71/18614 0.00121029962791823 0.0175588000706574 0.0125210274006672 ABCA1/CETP/APOA2 3 BP GO:0048002 antigen processing and presentation of peptide antigen 3/55 71/18614 0.00121029962791823 0.0175588000706574 0.0125210274006672 TAP1/HLA-C/HLA-DOA 3 BP GO:0043254 regulation of protein-containing complex assembly 6/55 409/18614 0.00126686354997132 0.0182369427309826 0.0130046050254094 ABCA1/SH3GLB1/MYD88/RALB/IRGM/GBP5 6 BP GO:0050727 regulation of inflammatory response 6/55 414/18614 0.00134800527524814 0.0192557368933523 0.0137310982693293 JAK2/ZBP1/MYD88/LRRK2/NOD2/NKG7 6 BP GO:0051100 negative regulation of binding 4/55 163/18614 0.00136551947105443 0.0193570202881532 0.0138033225760263 JAK2/C9orf72/LRRK2/RALB 4 BP GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 2/55 19/18614 0.00141934963362907 0.0196456924975581 0.0140091722143401 APOBEC3A/APOBEC3B 2 BP GO:2000786 positive regulation of autophagosome assembly 2/55 19/18614 0.00141934963362907 0.0196456924975581 0.0140091722143401 SH3GLB1/RALB 2 BP GO:0007034 vacuolar transport 4/55 165/18614 0.00142820058544445 0.0196456924975581 0.0140091722143401 SCARB2/C9orf72/LRRK2/LAMP2 4 BP GO:0050792 regulation of viral process 4/55 165/18614 0.00142820058544445 0.0196456924975581 0.0140091722143401 APOBEC3A/STAT1/APOBEC3B/ADAR 4 BP GO:0070665 positive regulation of leukocyte proliferation 4/55 166/18614 0.00146028306797013 0.0199393063030922 0.0142185456618144 JAK2/CHRNB2/MYD88/CD6 4 BP GO:0002577 regulation of antigen processing and presentation 2/55 20/18614 0.00157407134619061 0.0208789320705426 0.0148885846128405 HLA-DOA/NOD2 2 BP GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 2/55 20/18614 0.00157407134619061 0.0208789320705426 0.0148885846128405 APOBEC3A/APOBEC3B 2 BP GO:0042454 ribonucleoside catabolic process 2/55 20/18614 0.00157407134619061 0.0208789320705426 0.0148885846128405 APOBEC3A/APOBEC3B 2 BP GO:1900227 positive regulation of NLRP3 inflammasome complex assembly 2/55 20/18614 0.00157407134619061 0.0208789320705426 0.0148885846128405 MYD88/GBP5 2 BP GO:0009267 cellular response to starvation 4/55 170/18614 0.00159365593517835 0.0209887877420298 0.0149669217353816 SH3GLB1/LRRK2/LAMP2/RALB 4 BP GO:0002262 myeloid cell homeostasis 4/55 171/18614 0.00162828058714484 0.0212379843443773 0.0151446216621187 JAK2/STAT1/ADAR/RHAG 4 BP GO:0032371 regulation of sterol transport 3/55 79/18614 0.00164688731588063 0.0212379843443773 0.0151446216621187 ABCA1/CETP/APOA2 3 BP GO:0032374 regulation of cholesterol transport 3/55 79/18614 0.00164688731588063 0.0212379843443773 0.0151446216621187 ABCA1/CETP/APOA2 3 BP GO:0044090 positive regulation of vacuole organization 2/55 21/18614 0.00173647207945509 0.0222388182865386 0.0158583076294337 SH3GLB1/RALB 2 BP GO:0015850 organic hydroxy compound transport 5/55 296/18614 0.00178562839310256 0.0227117255204894 0.0161955336591422 ABCA1/CHRNB2/CETP/SLC22A1/APOA2 5 BP GO:0048660 regulation of smooth muscle cell proliferation 4/55 176/18614 0.00180929891188914 0.0228562454379464 0.0162985895535735 JAK2/STAT1/MYD88/DBH 4 BP GO:0030522 intracellular receptor signaling pathway 5/55 299/18614 0.00186611065646439 0.0234146451963133 0.0166967795578393 JAK2/TASL/MYD88/IRGM/NOD2 5 BP GO:1902774 late endosome to lysosome transport 2/55 22/18614 0.0019065067739347 0.0237609602630653 0.0169437338156824 C9orf72/LRRK2 2 BP GO:0048659 smooth muscle cell proliferation 4/55 180/18614 0.00196383442422842 0.0243122701719478 0.0173368681100305 JAK2/STAT1/MYD88/DBH 4 BP GO:0006869 lipid transport 6/55 447/18614 0.00198797303171466 0.0244481186747955 0.0174337404942283 SCARB2/ABCA1/APOL6/CETP/SLC22A1/APOA2 6 BP GO:0019835 cytolysis 2/55 23/18614 0.00208413056097333 0.0252956238674998 0.0180380890657341 GZMM/NKG7 2 BP GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 2/55 23/18614 0.00208413056097333 0.0252956238674998 0.0180380890657341 TAP1/HLA-C 2 BP GO:0045069 regulation of viral genome replication 3/55 86/18614 0.00210049496752349 0.0253286958096826 0.018061672379662 APOBEC3A/APOBEC3B/ADAR 3 BP GO:0072594 establishment of protein localization to organelle 6/55 453/18614 0.00212558646752455 0.0254658972270522 0.018159509515422 JAK2/SCARB2/SH3GLB1/CDK1/LRRK2/LAMP2 6 BP GO:0032640 tumor necrosis factor production 4/55 185/18614 0.00216958463567806 0.0255160254379404 0.0181952555060108 JAK2/MYD88/LRRK2/NOD2 4 BP GO:0032680 regulation of tumor necrosis factor production 4/55 185/18614 0.00216958463567806 0.0255160254379404 0.0181952555060108 JAK2/MYD88/LRRK2/NOD2 4 BP GO:0097006 regulation of plasma lipoprotein particle levels 3/55 87/18614 0.00217099193279191 0.0255160254379404 0.0181952555060108 ABCA1/CETP/APOA2 3 BP GO:0051453 regulation of intracellular pH 3/55 88/18614 0.00224294512968424 0.0260128876612221 0.0185495636299733 TASL/ATP6V0A1/LRRK2 3 BP GO:0006213 pyrimidine nucleoside metabolic process 2/55 24/18614 0.00226929876204522 0.0260128876612221 0.0185495636299733 APOBEC3A/APOBEC3B 2 BP GO:0035458 cellular response to interferon-beta 2/55 24/18614 0.00226929876204522 0.0260128876612221 0.0185495636299733 STAT1/IRGM 2 BP GO:0060907 positive regulation of macrophage cytokine production 2/55 24/18614 0.00226929876204522 0.0260128876612221 0.0185495636299733 MYD88/NOD2 2 BP GO:0042742 defense response to bacterium 5/55 314/18614 0.00230906189225525 0.0263063063430552 0.018758797936436 MYD88/GBP4/IRGM/GNLY/NOD2 5 BP GO:0002221 pattern recognition receptor signaling pathway 4/55 189/18614 0.00234456659488069 0.0265479278456917 0.018931096125545 TASL/MYD88/IRGM/NOD2 4 BP GO:0071706 tumor necrosis factor superfamily cytokine production 4/55 190/18614 0.00238978768670641 0.0265902589997562 0.0189612821028219 JAK2/MYD88/LRRK2/NOD2 4 BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 4/55 190/18614 0.00238978768670641 0.0265902589997562 0.0189612821028219 JAK2/MYD88/LRRK2/NOD2 4 BP GO:0048525 negative regulation of viral process 3/55 90/18614 0.00239126184865875 0.0265902589997562 0.0189612821028219 APOBEC3A/STAT1/APOBEC3B 3 BP GO:0002483 antigen processing and presentation of endogenous peptide antigen 2/55 25/18614 0.00246196688805611 0.0267977683625023 0.0191092552220774 TAP1/HLA-C 2 BP GO:0009164 nucleoside catabolic process 2/55 25/18614 0.00246196688805611 0.0267977683625023 0.0191092552220774 APOBEC3A/APOBEC3B 2 BP GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 2/55 25/18614 0.00246196688805611 0.0267977683625023 0.0191092552220774 IRGM/NOD2 2 BP GO:0070098 chemokine-mediated signaling pathway 3/55 91/18614 0.00246764587506079 0.0267977683625023 0.0191092552220774 CXCL10/CXCR6/CXCL11 3 BP GO:0031647 regulation of protein stability 5/55 322/18614 0.00257445815293202 0.0277951673836905 0.0198204917771633 SH3GLB1/LRRK2/LAMP2/APOA2/IRGM 5 BP GO:0030641 regulation of cellular pH 3/55 93/18614 0.00262491559788173 0.0278544429558694 0.0198627606714189 TASL/ATP6V0A1/LRRK2 3 BP GO:0031334 positive regulation of protein-containing complex assembly 4/55 195/18614 0.00262494750526502 0.0278544429558694 0.0198627606714189 ABCA1/SH3GLB1/MYD88/GBP5 4 BP GO:0071902 positive regulation of protein serine/threonine kinase activity 4/55 195/18614 0.00262494750526502 0.0278544429558694 0.0198627606714189 LRRK2/RALB/IRGM/NOD2 4 BP GO:0034377 plasma lipoprotein particle assembly 2/55 26/18614 0.00266209063864662 0.0279293916156314 0.0199162059079241 ABCA1/APOA2 2 BP GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 2/55 26/18614 0.00266209063864662 0.0279293916156314 0.0199162059079241 IRGM/NOD2 2 BP GO:0071496 cellular response to external stimulus 5/55 327/18614 0.00275121519245435 0.0287022843392569 0.0204673489775729 SH3GLB1/MYD88/LRRK2/LAMP2/RALB 5 BP GO:0010818 T cell chemotaxis 2/55 27/18614 0.00286962590149807 0.0297703647993403 0.0212289878511295 CXCL10/CXCL11 2 BP GO:0010528 regulation of transposition 2/55 28/18614 0.00308452875164063 0.0312838497820532 0.0223082408104883 APOBEC3A/APOBEC3B 2 BP GO:0010529 negative regulation of transposition 2/55 28/18614 0.00308452875164063 0.0312838497820532 0.0223082408104883 APOBEC3A/APOBEC3B 2 BP GO:0032703 negative regulation of interleukin-2 production 2/55 28/18614 0.00308452875164063 0.0312838497820532 0.0223082408104883 GBP1/NOD2 2 BP GO:0042632 cholesterol homeostasis 3/55 99/18614 0.00313343891193425 0.0312838497820532 0.0223082408104883 ABCA1/CETP/APOA2 3 BP GO:0048661 positive regulation of smooth muscle cell proliferation 3/55 99/18614 0.00313343891193425 0.0312838497820532 0.0223082408104883 JAK2/STAT1/MYD88 3 BP GO:1990868 response to chemokine 3/55 99/18614 0.00313343891193425 0.0312838497820532 0.0223082408104883 CXCL10/CXCR6/CXCL11 3 BP GO:1990869 cellular response to chemokine 3/55 99/18614 0.00313343891193425 0.0312838497820532 0.0223082408104883 CXCL10/CXCR6/CXCL11 3 BP GO:0006641 triglyceride metabolic process 3/55 100/18614 0.00322364599899583 0.0317970232073132 0.0226741803105178 CETP/SLC22A4/APOA2 3 BP GO:0055092 sterol homeostasis 3/55 100/18614 0.00322364599899583 0.0317970232073132 0.0226741803105178 ABCA1/CETP/APOA2 3 BP GO:0042594 response to starvation 4/55 207/18614 0.00325333032277302 0.0317970232073132 0.0226741803105178 SH3GLB1/LRRK2/LAMP2/RALB 4 BP GO:1902115 regulation of organelle assembly 4/55 207/18614 0.00325333032277302 0.0317970232073132 0.0226741803105178 SH3GLB1/C9orf72/LRRK2/RALB 4 BP GO:0002253 activation of immune response 6/55 495/18614 0.00330120281095823 0.0319825253753561 0.0228064602909038 ZBP1/TASL/GBP1/MYD88/IRGM/NOD2 6 BP GO:0065005 protein-lipid complex assembly 2/55 29/18614 0.00330675545076379 0.0319825253753561 0.0228064602909038 ABCA1/APOA2 2 BP GO:0002758 innate immune response-activating signaling pathway 4/55 209/18614 0.00336719305797418 0.0322320127909392 0.0229843675940263 TASL/MYD88/IRGM/NOD2 4 BP GO:0010876 lipid localization 6/55 497/18614 0.00336726466421228 0.0322320127909392 0.0229843675940263 SCARB2/ABCA1/APOL6/CETP/SLC22A1/APOA2 6 BP GO:0006885 regulation of pH 3/55 103/18614 0.00350379721224383 0.0326708426030078 0.0232972933109905 TASL/ATP6V0A1/LRRK2 3 BP GO:0032677 regulation of interleukin-8 production 3/55 103/18614 0.00350379721224383 0.0326708426030078 0.0232972933109905 MYD88/APOA2/NOD2 3 BP GO:0034368 protein-lipid complex remodeling 2/55 30/18614 0.00353626244652912 0.0326708426030078 0.0232972933109905 CETP/APOA2 2 BP GO:0034369 plasma lipoprotein particle remodeling 2/55 30/18614 0.00353626244652912 0.0326708426030078 0.0232972933109905 CETP/APOA2 2 BP GO:0034656 nucleobase-containing small molecule catabolic process 2/55 30/18614 0.00353626244652912 0.0326708426030078 0.0232972933109905 APOBEC3A/APOBEC3B 2 BP GO:0039694 viral RNA genome replication 2/55 30/18614 0.00353626244652912 0.0326708426030078 0.0232972933109905 APOBEC3A/APOBEC3B 2 BP GO:0070498 interleukin-1-mediated signaling pathway 2/55 30/18614 0.00353626244652912 0.0326708426030078 0.0232972933109905 ZBP1/MYD88 2 BP GO:0032637 interleukin-8 production 3/55 104/18614 0.00360038680558183 0.0330986054354726 0.0236023272611878 MYD88/APOA2/NOD2 3 BP GO:1900225 regulation of NLRP3 inflammasome complex assembly 2/55 31/18614 0.00377300637188541 0.0345146444955232 0.0246120923818089 MYD88/GBP5 2 BP GO:0015837 amine transport 3/55 107/18614 0.00389989262206544 0.0351861560869104 0.0250909414490453 CHRNB2/RGS2/SLC22A16 3 BP GO:0030593 neutrophil chemotaxis 3/55 107/18614 0.00389989262206544 0.0351861560869104 0.0250909414490453 CXCL10/CXCL11/NOD2 3 BP GO:0001975 response to amphetamine 2/55 32/18614 0.00401694404438611 0.0351861560869104 0.0250909414490453 RGS2/DBH 2 BP GO:0006622 protein targeting to lysosome 2/55 32/18614 0.00401694404438611 0.0351861560869104 0.0250909414490453 SCARB2/LAMP2 2 BP GO:0010743 regulation of macrophage derived foam cell differentiation 2/55 32/18614 0.00401694404438611 0.0351861560869104 0.0250909414490453 ABCA1/CETP 2 BP GO:0019883 antigen processing and presentation of endogenous antigen 2/55 32/18614 0.00401694404438611 0.0351861560869104 0.0250909414490453 TAP1/HLA-C 2 BP GO:0032196 transposition 2/55 32/18614 0.00401694404438611 0.0351861560869104 0.0250909414490453 APOBEC3A/APOBEC3B 2 BP GO:0034367 protein-containing complex remodeling 2/55 32/18614 0.00401694404438611 0.0351861560869104 0.0250909414490453 CETP/APOA2 2 BP GO:0035456 response to interferon-beta 2/55 32/18614 0.00401694404438611 0.0351861560869104 0.0250909414490453 STAT1/IRGM 2 BP GO:0018107 peptidyl-threonine phosphorylation 3/55 109/18614 0.00410776016647719 0.0358127259584419 0.025537742967276 CDK1/LRRK2/IRGM 3 BP GO:0071404 cellular response to low-density lipoprotein particle stimulus 2/55 33/18614 0.00426803246550903 0.0368638897137222 0.0262873186859748 ABCA1/MYD88 2 BP GO:0080111 DNA demethylation 2/55 33/18614 0.00426803246550903 0.0368638897137222 0.0262873186859748 APOBEC3A/APOBEC3B 2 BP GO:0033157 regulation of intracellular protein transport 4/55 224/18614 0.00430906693353052 0.0369881925722497 0.0263759579717655 JAK2/SH3GLB1/CDK1/LRRK2 4 BP GO:0071347 cellular response to interleukin-1 3/55 111/18614 0.00432226052136682 0.0369881925722497 0.0263759579717655 ZBP1/GBP1/MYD88 3 BP GO:0006066 alcohol metabolic process 5/55 366/18614 0.00444612203341071 0.0377006786120717 0.0268840255613106 ABCA1/SPTLC2/CETP/APOA2/DBH 5 BP GO:0045860 positive regulation of protein kinase activity 5/55 366/18614 0.00444612203341071 0.0377006786120717 0.0268840255613106 JAK2/LRRK2/RALB/IRGM/NOD2 5 BP GO:0044546 NLRP3 inflammasome complex assembly 2/55 34/18614 0.00452622881997843 0.0378612924265764 0.0269985578735556 MYD88/GBP5 2 BP GO:0055094 response to lipoprotein particle 2/55 34/18614 0.00452622881997843 0.0378612924265764 0.0269985578735556 ABCA1/MYD88 2 BP GO:1901658 glycosyl compound catabolic process 2/55 34/18614 0.00452622881997843 0.0378612924265764 0.0269985578735556 APOBEC3A/APOBEC3B 2 BP GO:0071900 regulation of protein serine/threonine kinase activity 5/55 369/18614 0.00460163240378929 0.0383194232010615 0.0273252469387157 LRRK2/RGS2/RALB/IRGM/NOD2 5 BP GO:0031669 cellular response to nutrient levels 4/55 230/18614 0.00473106030913801 0.0391973471904879 0.0279512868892293 SH3GLB1/LRRK2/LAMP2/RALB 4 BP GO:0002719 negative regulation of cytokine production involved in immune response 2/55 35/18614 0.00479149047508926 0.0391973471904879 0.0279512868892293 APOA2/NOD2 2 BP GO:0009119 ribonucleoside metabolic process 2/55 35/18614 0.00479149047508926 0.0391973471904879 0.0279512868892293 APOBEC3A/APOBEC3B 2 BP GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 2/55 35/18614 0.00479149047508926 0.0391973471904879 0.0279512868892293 MYD88/NOD2 2 BP GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 4/55 234/18614 0.00502736331326094 0.0408844788605339 0.0291543657889361 ABCA1/CXCL10/RGS2/CXCL11 4 BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 2/55 36/18614 0.00506377498003382 0.0408844788605339 0.0291543657889361 TAP1/HLA-C 2 BP GO:0140632 inflammasome complex assembly 2/55 36/18614 0.00506377498003382 0.0408844788605339 0.0291543657889361 MYD88/GBP5 2 BP GO:0071356 cellular response to tumor necrosis factor 4/55 235/18614 0.00510334368576113 0.0410255810582616 0.0292549845371953 JAK2/STAT1/GBP1/LRRK2 4 BP GO:0050830 defense response to Gram-positive bacterium 3/55 118/18614 0.00512613182618522 0.0410311500052843 0.029258955704814 MYD88/GBP4/NOD2 3 BP GO:0006909 phagocytosis 4/55 236/18614 0.0051800929983171 0.0412851188749994 0.0294400586938465 ABCA1/MYD88/APOA2/NOD2 4 BP GO:0002718 regulation of cytokine production involved in immune response 3/55 119/18614 0.00524781407003228 0.0414688967151061 0.0295711090709994 MYD88/APOA2/NOD2 3 BP GO:0018210 peptidyl-threonine modification 3/55 119/18614 0.00524781407003228 0.0414688967151061 0.0295711090709994 CDK1/LRRK2/IRGM 3 BP GO:0010934 macrophage cytokine production 2/55 37/18614 0.00534304006523064 0.0416891823577029 0.0297281928441404 MYD88/NOD2 2 BP GO:0010935 regulation of macrophage cytokine production 2/55 37/18614 0.00534304006523064 0.0416891823577029 0.0297281928441404 MYD88/NOD2 2 BP GO:0071402 cellular response to lipoprotein particle stimulus 2/55 37/18614 0.00534304006523064 0.0416891823577029 0.0297281928441404 ABCA1/MYD88 2 BP GO:0050670 regulation of lymphocyte proliferation 4/55 239/18614 0.00541498973423577 0.0420737905291876 0.0300024535814517 JAK2/CHRNB2/MYD88/CD6 4 BP GO:0002274 myeloid leukocyte activation 4/55 240/18614 0.00549484989746462 0.0423218843828116 0.0301793671476785 JAK2/MYD88/LRRK2/BATF2 4 BP GO:0002367 cytokine production involved in immune response 3/55 121/18614 0.00549638158138436 0.0423218843828116 0.0301793671476785 MYD88/APOA2/NOD2 3 BP GO:0097529 myeloid leukocyte migration 4/55 241/18614 0.00557549647819123 0.0423218843828116 0.0301793671476785 CXCL10/MYD88/CXCL11/NOD2 4 BP GO:0032373 positive regulation of sterol transport 2/55 38/18614 0.00562924364165561 0.0423218843828116 0.0301793671476785 ABCA1/CETP 2 BP GO:0032376 positive regulation of cholesterol transport 2/55 38/18614 0.00562924364165561 0.0423218843828116 0.0301793671476785 ABCA1/CETP 2 BP GO:0035510 DNA dealkylation 2/55 38/18614 0.00562924364165561 0.0423218843828116 0.0301793671476785 APOBEC3A/APOBEC3B 2 BP GO:0072529 pyrimidine-containing compound catabolic process 2/55 38/18614 0.00562924364165561 0.0423218843828116 0.0301793671476785 APOBEC3A/APOBEC3B 2 BP GO:0140894 endolysosomal toll-like receptor signaling pathway 2/55 38/18614 0.00562924364165561 0.0423218843828116 0.0301793671476785 TASL/MYD88 2 BP GO:0032944 regulation of mononuclear cell proliferation 4/55 243/18614 0.00573916269629369 0.042896933674882 0.0305894297894179 JAK2/CHRNB2/MYD88/CD6 4 BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3/55 123/18614 0.0057519313328194 0.042896933674882 0.0305894297894179 JAK2/HLA-C/NOD2 3 BP GO:0030301 cholesterol transport 3/55 124/18614 0.00588234099608566 0.0436420334798639 0.0311207539708464 ABCA1/CETP/APOA2 3 BP GO:0042307 positive regulation of protein import into nucleus 2/55 39/18614 0.00592234380017539 0.0436420334798639 0.0311207539708464 JAK2/CDK1 2 BP GO:0098926 postsynaptic signal transduction 2/55 39/18614 0.00592234380017539 0.0436420334798639 0.0311207539708464 JAK2/CHRNB2 2 BP GO:0050900 leukocyte migration 5/55 393/18614 0.00598870965057149 0.0439566554194121 0.0313451081357143 CXCL10/MYD88/CXCL11/NOD2/DBH 5 BP GO:0002456 T cell mediated immunity 3/55 125/18614 0.00601451575516751 0.043972266761205 0.0313562404475786 GZMM/HLA-C/NOD2 3 BP GO:1901998 toxin transport 2/55 40/18614 0.00622229881088309 0.0453129760463133 0.0323122885617788 ATP6V0A1/SLC22A1 2 BP GO:0050870 positive regulation of T cell activation 4/55 249/18614 0.00624939176139196 0.0453325019566596 0.0323262123183844 JAK2/CD6/HLA-DOA/NOD2 4 BP GO:0006959 humoral immune response 4/55 250/18614 0.00633726987075131 0.0457910900777633 0.032653227513435 CXCL10/CXCL11/GNLY/NOD2 4 BP GO:0006639 acylglycerol metabolic process 3/55 128/18614 0.0064216931475967 0.0462212564925856 0.0329599754372772 CETP/SLC22A4/APOA2 3 BP GO:0042417 dopamine metabolic process 2/55 41/18614 0.00652906712243618 0.0463260800671544 0.0330347242153333 CHRNB2/DBH 2 BP GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2/55 41/18614 0.00652906712243618 0.0463260800671544 0.0330347242153333 CXCL10/CXCL11 2 BP GO:0002821 positive regulation of adaptive immune response 3/55 129/18614 0.00656099033799763 0.0463260800671544 0.0330347242153333 JAK2/HLA-C/NOD2 3 BP GO:0006638 neutral lipid metabolic process 3/55 129/18614 0.00656099033799763 0.0463260800671544 0.0330347242153333 CETP/SLC22A4/APOA2 3 BP GO:0042542 response to hydrogen peroxide 3/55 129/18614 0.00656099033799763 0.0463260800671544 0.0330347242153333 STAT1/CDK1/LRRK2 3 BP GO:0060338 regulation of type I interferon-mediated signaling pathway 2/55 42/18614 0.00684260736139661 0.0479665021695337 0.0342044949291576 ZBP1/ADAR 2 BP GO:0071621 granulocyte chemotaxis 3/55 131/18614 0.0068449774232237 0.0479665021695337 0.0342044949291576 CXCL10/CXCL11/NOD2 3 BP GO:0034612 response to tumor necrosis factor 4/55 257/18614 0.00697557028512657 0.0486978722536844 0.0347260285662415 JAK2/STAT1/GBP1/LRRK2 4 CC GO:0045335 phagocytic vesicle 8/55 141/19518 0.0000000055539133773784 0.000000971934841041221 0.000000713239402147542 ABCA1/ATP6V0A1/TAP1/LAMP2/HLA-C/IRGM/GNLY/NOD2 8 CC GO:0030139 endocytic vesicle 9/55 347/19518 0.000000495062286090174 0.0000433179500328903 0.000031788209948948 SCARB2/ABCA1/ATP6V0A1/TAP1/LAMP2/HLA-C/IRGM/GNLY/NOD2 9 CC GO:0005776 autophagosome 6/55 117/19518 0.000000930328533427343 0.0000542691644499284 0.0000398245898519775 RUFY4/SH3GLB1/C9orf72/LRRK2/LAMP2/IRGM 6 CC GO:0030670 phagocytic vesicle membrane 5/55 78/19518 0.00000266340305274397 0.000116523883557549 0.0000855092559038855 ATP6V0A1/TAP1/LAMP2/HLA-C/IRGM 5 CC GO:0030666 endocytic vesicle membrane 6/55 196/19518 0.0000182881355405498 0.000640084743919243 0.000469716323357279 SCARB2/ATP6V0A1/TAP1/LAMP2/HLA-C/IRGM 6 CC GO:0005774 vacuolar membrane 8/55 460/19518 0.000041272683972639 0.00120378661586864 0.000883380253449466 TASL/SCARB2/ATP6V0A1/SH3GLB1/LAMP2/HLA-DOA/IRGM/NKG7 8 CC GO:0030496 midbody 5/55 203/19518 0.00026420427803172 0.006605106950793 0.00484705592779998 LAP3/SH3GLB1/C9orf72/CDK1/RALB 5 CC GO:0000421 autophagosome membrane 3/55 51/19518 0.000400652872516864 0.00876428158630639 0.00643153295356018 SH3GLB1/LAMP2/IRGM 3 CC GO:0044754 autolysosome 2/55 12/19518 0.0005053459082632 0.00982617043845111 0.00721078372024683 LRRK2/LAMP2 2 CC GO:0044194 cytolytic granule 2/55 13/19518 0.000596147756964684 0.010432585746882 0.00765579224733594 GNLY/NKG7 2 CC GO:0005765 lysosomal membrane 6/55 415/19518 0.00107156423089124 0.0155998401226373 0.0114477022253339 TASL/SCARB2/ATP6V0A1/LAMP2/HLA-DOA/NKG7 6 CC GO:0098852 lytic vacuole membrane 6/55 415/19518 0.00107156423089124 0.0155998401226373 0.0114477022253339 TASL/SCARB2/ATP6V0A1/LAMP2/HLA-DOA/NKG7 6 CC GO:0005767 secondary lysosome 2/55 18/19518 0.00115884526625306 0.0155998401226373 0.0114477022253339 LRRK2/LAMP2 2 CC GO:0098857 membrane microdomain 5/55 324/19518 0.00215569149677308 0.0261765827002933 0.0192092817409671 JAK2/ABCA1/CHRNB2/LRRK2/LAMP2 5 CC GO:0042611 MHC protein complex 2/55 25/19518 0.00224370708859657 0.0261765827002933 0.0192092817409671 HLA-C/HLA-DOA 2 CC GO:0034364 high-density lipoprotein particle 2/55 27/19518 0.00261568267393653 0.0274368601823067 0.020134116945813 CETP/APOA2 2 CC GO:0000932 P-body 3/55 98/19518 0.00266529498913836 0.0274368601823067 0.020134116945813 APOBEC3A/APOBEC3B/C9orf72 3 CC GO:0044853 plasma membrane raft 3/55 114/19518 0.00408239467783554 0.0384940283358846 0.0282482493652807 JAK2/CHRNB2/LRRK2 3 CC GO:0030658 transport vesicle membrane 4/55 234/19518 0.00425593922912175 0.0384940283358846 0.0282482493652807 ATP6V0A1/LRRK2/HLA-C/DBH 4 CC GO:0034358 plasma lipoprotein particle 2/55 36/19518 0.00461928340030615 0.0384940283358846 0.0282482493652807 CETP/APOA2 2 CC GO:1990777 lipoprotein particle 2/55 36/19518 0.00461928340030615 0.0384940283358846 0.0282482493652807 CETP/APOA2 2 CC GO:0032994 protein-lipid complex 2/55 39/19518 0.00540389658094332 0.0429855409847764 0.0315442766925878 CETP/APOA2 2 MF GO:0050997 quaternary ammonium group binding 5/55 53/18369 0.000000513946429476618 0.000148016571689266 0.000110904229518639 SCARB2/ABCA1/CHRNB2/CETP/APOA2 5 MF GO:0031210 phosphatidylcholine binding 4/55 30/18369 0.00000186023020202943 0.000233291251419425 0.000174797904024058 SCARB2/ABCA1/CETP/APOA2 4 MF GO:0019239 deaminase activity 4/55 32/18369 0.00000243011720228568 0.000233291251419425 0.000174797904024058 APOBEC3A/ZBP1/APOBEC3B/ADAR 4 MF GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/55 35/18369 0.00000351490432937696 0.000253073111715141 0.000189619838821652 APOBEC3A/ZBP1/APOBEC3B/ADAR 4 MF GO:0015485 cholesterol binding 4/55 50/18369 0.0000149536064248975 0.000861327730074098 0.000645366172021893 SCARB2/ABCA1/CETP/APOA2 4 MF GO:0015651 quaternary ammonium group transmembrane transporter activity 3/55 18/18369 0.0000200769828009851 0.000963695174447286 0.000722066925298588 SLC22A1/SLC22A4/SLC22A16 3 MF GO:0032934 sterol binding 4/55 59/18369 0.0000289675502514151 0.00119180778177251 0.00089298463181054 SCARB2/ABCA1/CETP/APOA2 4 MF GO:0120020 cholesterol transfer activity 3/55 22/18369 0.000037570091381212 0.00135252328972363 0.00101340378067743 ABCA1/CETP/APOA2 3 MF GO:0120015 sterol transfer activity 3/55 23/18369 0.0000431140313559067 0.00137964900338902 0.00103372823718841 ABCA1/CETP/APOA2 3 MF GO:0003924 GTPase activity 7/55 327/18369 0.000051790630999281 0.00149157017277929 0.0011175873005108 GBP1/LRRK2/GBP4/RGS2/RALB/IRGM/GBP5 7 MF GO:0015101 organic cation transmembrane transporter activity 3/55 32/18369 0.00011846574682181 0.00310164864406192 0.00232396919602593 SLC22A1/SLC22A4/SLC22A16 3 MF GO:0043178 alcohol binding 4/55 88/18369 0.000139178687086084 0.00334028849006601 0.00250277463619712 SCARB2/ABCA1/CETP/APOA2 4 MF GO:0072349 modified amino acid transmembrane transporter activity 3/55 35/18369 0.00015533147409669 0.0034411895799882 0.0025783766955321 SLC22A1/SLC22A4/SLC22A16 3 MF GO:0015248 sterol transporter activity 3/55 36/18369 0.000169093835771898 0.00347850176445047 0.00260633355889015 ABCA1/CETP/APOA2 3 MF GO:0005496 steroid binding 4/55 99/18369 0.000219270483028044 0.00420999327413845 0.00315441747514028 SCARB2/ABCA1/CETP/APOA2 4 MF GO:0120013 lipid transfer activity 3/55 51/18369 0.000477773583779286 0.00859992450802714 0.00644365688649695 ABCA1/CETP/APOA2 3 MF GO:0004126 cytidine deaminase activity 2/55 12/18369 0.000569898887434682 0.00932468538884515 0.00698669775114494 APOBEC3A/APOBEC3B 2 MF GO:0031072 heat shock protein binding 4/55 128/18369 0.000582792836802822 0.00932468538884515 0.00698669775114494 GBP1/CDK1/APOA2/NOD2 4 MF GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4/55 131/18369 0.000635850723922994 0.0096381583415696 0.00722157331879301 APOBEC3A/ZBP1/APOBEC3B/ADAR 4 MF GO:0004000 adenosine deaminase activity 2/55 13/18369 0.000672223796627217 0.00968002267143192 0.00725294096360945 ZBP1/ADAR 2 MF GO:0050700 CARD domain binding 2/55 15/18369 0.000901446375820181 0.0123626931541053 0.00926298280917981 IRGM/NOD2 2 MF GO:0005525 GTP binding 6/55 382/18369 0.000954292480342368 0.0124925561063001 0.00936028509426725 GBP1/LRRK2/GBP4/RALB/IRGM/GBP5 6 MF GO:0005126 cytokine receptor binding 5/55 270/18369 0.00126245577705413 0.0144663648142851 0.0108391987826332 JAK2/STAT1/CXCL10/MYD88/CXCL11 5 MF GO:0019001 guanyl nucleotide binding 6/55 404/18369 0.00127262267182331 0.0144663648142851 0.0108391987826332 GBP1/LRRK2/GBP4/RALB/IRGM/GBP5 6 MF GO:0032561 guanyl ribonucleotide binding 6/55 404/18369 0.00127262267182331 0.0144663648142851 0.0108391987826332 GBP1/LRRK2/GBP4/RALB/IRGM/GBP5 6 MF GO:0045236 CXCR chemokine receptor binding 2/55 18/18369 0.00130599126795629 0.0144663648142851 0.0108391987826332 CXCL10/CXCL11 2 MF GO:0042379 chemokine receptor binding 3/55 74/18369 0.00141666171384647 0.015111058281029 0.0113222476155371 STAT1/CXCL10/CXCL11 3 MF GO:0005319 lipid transporter activity 4/55 169/18369 0.0016365714471577 0.016833306313622 0.0126126746867417 ABCA1/CETP/SLC22A1/APOA2 4 MF GO:0035173 histone kinase activity 2/55 21/18369 0.00178224705048453 0.0176995569151567 0.0132617294137687 JAK2/CDK1 2 MF GO:0038024 cargo receptor activity 3/55 83/18369 0.00197020209913766 0.0189139401517216 0.0141716291341481 SCARB2/ABCA1/CD6 3 MF GO:0051117 ATPase binding 3/55 86/18369 0.00218063918707258 0.0202588414799001 0.015179322015276 ABCA1/ATP6V0A1/RALB 3 MF GO:0005543 phospholipid binding 6/55 475/18369 0.00287478525543843 0.0258730672989459 0.0193858874133183 SCARB2/ABCA1/SESTD1/CETP/RUFY4/APOA2 6 MF GO:0042626 ATPase-coupled transmembrane transporter activity 3/55 99/18369 0.00325183255024987 0.0283796295294534 0.0212639768038668 ABCA1/ATP6V0A1/TAP1 3