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["Supplementary Table S7. List of genes identified by RIP-seq."]
["Geneid","RIP_4h_rep1","Input_4h_rep1","logFC","logCPM","PValue","FDR","GeneID","uniprotAc","Refseq","pfam","interpro","eggNOG","GO(GO_term,class,description)","KEGG(KO,pathway,description)"]
["CTD-2561B21.4",12.97859094,0,7.548963716,2.019477705,{"v":4.11e-07,"d":"4.11E-07"},{"v":2.1e-06,"d":"2.10E-06"},"ENSG00000262313","G3S879,Uncharacterized protein","-","PF00400,WD domain, G-beta repeat","IPR029347,Raptor, N-terminal CASPase-like domain;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR004083,Regulatory associated protein of TOR;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR016024,Armadillo-type fold;IPR001680,WD40 repeat","-","GO:0031931,cellular_component,TORC1 complex;GO:0031929,biological_process,TOR signaling","-"]
["RP11-706O15.1",2.021599141,0,7.494812205,1.973933969,{"v":7.45e-07,"d":"7.45E-07"},{"v":3.61e-06,"d":"3.61E-06"},"ENSG00000205664","H2PG84,Uncharacterized protein","-","-","-","-","-","-"]
["FOXP2",0.323655486,0,7.255257655,1.77503091,{"v":8.35e-06,"d":"8.35E-06"},{"v":3.23e-05,"d":"3.23E-05"},"ENSG00000128573","G7P2I0,Uncharacterized protein","-","PF00250,orkhead domain;PF16159,OXP coiled-coil domain","IPR032354,FOXP, coiled-coil domain;IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily","-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["TARID",0.63427411,0,7.188593071,1.720470768,{"v":1.54e-05,"d":"1.54E-05"},{"v":5.62e-05,"d":"5.62E-05"},"ENSG00000227954","A0A0D9RLJ9,Uncharacterized protein","-","-","-","-","-","-"]
["TCAF2P1",2.059753429,0,7.188593071,1.720470768,{"v":1.54e-05,"d":"1.54E-05"},{"v":5.62e-05,"d":"5.62E-05"},"ENSG00000159860","A0A1B0GVM2,Uncharacterized protein","-","PF17291,N-terminal domain of M60-like peptidases;PF13402,Peptidase M60, enhancin and enhancin-like","IPR031161,Peptidase family M60 domain;IPR035423,M60-like domain, N-terminal","-","GO:0030054,cellular_component,cell junction;GO:0005886,cellular_component,plasma membrane","-"]
["DLEU7",1.299016112,0,7.118698154,1.663660145,{"v":1.54e-05,"d":"1.54E-05"},{"v":5.62e-05,"d":"5.62E-05"},"ENSG00000186047","H2Q7L1,Deleted in lymphocytic leukemia, 7","XP_001157783.1,-","PF15760,Leukemia-associated protein 7","IPR031510,Leukemia-associated protein 7","ENOG410IF39,-;ENOG410Y73I,-","-","-"]
["ZNF430",0.693820731,0,7.118698154,1.663660145,{"v":1.54e-05,"d":"1.54E-05"},{"v":5.62e-05,"d":"5.62E-05"},"ENSG00000118620","A8K360,cDNA FLJ77279, highly similar to Homo sapiens zinc finger protein 430","NP_079465.3,zinc finger protein 430 isoform 1;NP_001166142.1,zinc finger protein 430 isoform 2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["AF196970.3",5.134273412,0,7.118698154,1.663660145,{"v":1.54e-05,"d":"1.54E-05"},{"v":5.62e-05,"d":"5.62E-05"},"ENSG00000232828","G3S5S8,Histone-lysine N-methyltransferase","-","PF00856,SET domain;PF00385,Chromo (CHRromatin Organisation MOdifier) domain;PF05033,Pre-SET motif","IPR023780,Chromo domain;IPR007728,Pre-SET domain;IPR016197,Chromo-like domain superfamily;IPR011381,Histone H3-K9 methyltransferase;IPR003616,Post-SET domain;IPR001214,SET domain;IPR023779,Chromo domain, conserved site;IPR000953,Chromo/chromo shadow domain","-","GO:0005694,cellular_component,chromosome;GO:0034968,biological_process,histone lysine methylation;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["MAP2K6",0.69784206,0,6.967848027,1.542486036,{"v":5.33e-05,"d":"5.33E-05"},0.000171704,"ENSG00000108984","G3QTE4,Mitogen-activated protein kinase kinase 6","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["ARNTL2-AS1",5.02092347,0,6.886063653,1.477651854,{"v":9.96e-05,"d":"9.96E-05"},0.000301228,"-","-","-","-","-","-","-","-"]
["CDKL5",0.236417129,0,6.886063653,1.477651854,{"v":9.96e-05,"d":"9.96E-05"},0.000301228,"ENSG00000008086","G3R5F5,Cyclin dependent kinase like 5","XP_004063919.1,cyclin-dependent kinase-like 5","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0016301,molecular_function,kinase activity;GO:0005634,cellular_component,nucleus;GO:0046777,biological_process,protein autophosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-96K19.2",1.61058174,0,6.79936294,1.409614871,0.000187,0.000534433,"ENSG00000232811","K6ZC55,Ligand dependent nuclear receptor interacting factor 1","-","PF15741,Ligand-dependent nuclear receptor-interacting factor 1","-","-","-","-"]
["RP11-841O20.2",6.539349956,0,6.79936294,1.409614871,0.000187,0.000534433,"ENSG00000258757","I7GIJ8,Macaca fascicularis brain cDNA clone: QflA-20460, similar to human O-acyltransferase","-","-","-","-","GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016740,molecular_function,transferase activity","-"]
["SDR42E1",0.31897929,0,6.79936294,1.409614871,0.000187,0.000534433,"ENSG00000184860","H2QBL1,Short chain dehydrogenase/reductase family 42E, member 1","XP_016785736.1,-;XP_523439.2,-;XP_001148161.1,short-chain dehydrogenase/reductase family 42E member 1","PF07993,Male sterility protein;PF01370,NAD dependent epimerase/dehydratase family;PF02719,Polysaccharide biosynthesis protein;PF01073,3-beta hydroxysteroid dehydrogenase/isomerase family;PF13460,NAD(P)H-binding;PF04321,RmlD substrate binding domain;PF16363,P-mannose 4,6 dehydratase","IPR036291,NAD(P)-binding domain superfamily;IPR002225,3-beta hydroxysteroid dehydrogenase/isomerase","KOG1430,C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases;COG0451,Nucleoside-diphosphate-sugar epimerases","GO:0003854,molecular_function,3-beta-hydroxy-delta5-steroid dehydrogenase activity;GO:0016616,molecular_function,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016491,molecular_function,oxidoreductase activity;GO:0006694,biological_process,steroid biosynthetic process;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane","-"]
["ZNF519",0.240663985,0,6.79936294,1.409614871,0.000187,0.000534433,"ENSG00000175322","H2QEB0,Uncharacterized protein","XP_523986.3,zinc finger protein 519","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["AP001469.9",1.668582488,0,6.79936294,1.409614871,0.000187,0.000534433,"ENSG00000239415","H2PFS9,Uncharacterized protein","-","-","-","-","-","-"]
["SYNE3",0.196096795,0,6.707116794,1.338042713,0.000352487,0.000943384,"ENSG00000176438","K7DPQ3,Chromosome 14 open reading frame 49","XP_016782183.1,nesprin-3 isoform X3;XP_016782184.1,-","PF10541,Nuclear envelope localisation domain;PF00435,Spectrin repeat","IPR030267,Nesprin-3;IPR002017,Spectrin repeat;IPR018159,Spectrin/alpha-actinin;IPR012315,KASH domain","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);KOG0516,Dystonin, GAS (Growth-arrest-specific protein), and related proteins","GO:0008092,molecular_function,cytoskeletal protein binding;GO:0005640,cellular_component,nuclear outer membrane;GO:0007010,biological_process,cytoskeleton organization;GO:0090286,biological_process,cytoskeletal anchoring at nuclear membrane;GO:0034993,cellular_component,meiotic nuclear membrane microtubule tethering complex;GO:0016020,cellular_component,membrane;GO:0031965,cellular_component,nuclear membrane;GO:0051015,molecular_function,actin filament binding;GO:0008360,biological_process,regulation of cell shape;GO:0005635,cellular_component,nuclear envelope;GO:0090150,biological_process,establishment of protein localization to membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ALOX12-AS1",1.107212365,0,6.707116794,1.338042713,0.000352487,0.000943384,"ENSG00000215067","G3S2S6,Uncharacterized protein","-","-","-","-","-","-"]
["MAGI2",0.112972253,0,6.707116794,1.338042713,0.000352487,0.000943384,"ENSG00000187391","H2QUU4,Uncharacterized protein","XP_009451709.1,membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X2","PF00397,WW domain;PF00625,uanylate kinase;PF00595,PDZ domain (Also known as DHR or GLGF);PF16663,Unstructured region on MAGI;PF16666,Unstructured region on MAGI","IPR001202,WW domain;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR030036,Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;IPR008144,Guanylate kinase-like domain;IPR020590,Guanylate kinase, conserved site;IPR008145,Guanylate kinase/L-type calcium channel beta subunit;IPR036020,WW domain superfamily","ENOG410ISXI,-;ENOG410XNXK,-","GO:0046332,molecular_function,SMAD binding;GO:2000809,biological_process,positive regulation of synaptic vesicle clustering;GO:0060395,biological_process,SMAD protein signal transduction;GO:0005923,cellular_component,bicellular tight junction;GO:0005737,cellular_component,cytoplasm;GO:0070699,molecular_function,type II activin receptor binding;GO:0005634,cellular_component,nucleus;GO:0004871,molecular_function,signal transducer activity;GO:0019902,molecular_function,phosphatase binding;GO:0030425,cellular_component,dendrite;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0097118,biological_process,neuroligin clustering involved in postsynaptic membrane assembly;GO:0002092,biological_process,positive regulation of receptor internalization;GO:0032516,biological_process,positive regulation of phosphoprotein phosphatase activity;GO:0032926,biological_process,negative regulation of activin receptor signaling pathway;GO:0032947,molecular_function,protein-containing complex scaffold activity;GO:0031697,molecular_function,beta-1 adrenergic receptor binding;GO:0051898,biological_process,negative regulation of protein kinase B signaling;GO:0030159,molecular_function,receptor signaling complex scaffold activity","-"]
["KIAA0196-AS1",6.067976455,0,6.707116794,1.338042713,0.000352487,0.000943384,"ENSG00000253167","A0A1S3FW18,WASH complex subunit strumpellin","XP_012880580.1,WASH complex subunit strumpellin","-","IPR019393,WASH complex, subunit strumpellin","-","GO:0071203,cellular_component,WASH complex","-"]
["UTS2",1.856193207,0,6.608567071,1.262548729,0.000667207,0.001675357,"ENSG00000049247","Q5H8X8,Urotensin-2","-","-","-","-","-","-"]
["SMAD9",0.580891496,0,6.608567071,1.262548729,0.000667207,0.001675357,"ENSG00000120693","F6YCR1,Mothers against decapentaplegic homolog","-","PF03165,MH1 domain;PF03166,MH2 domain","IPR003619,MAD homology 1, Dwarfin-type;IPR001132,SMAD domain, Dwarfin-type;IPR013790,Dwarfin;IPR017855,SMAD-like domain superfamily;IPR008984,SMAD/FHA domain superfamily;IPR036578,SMAD MH1 domain superfamily;IPR013019,MAD homology, MH1","ENOG410XQKU,-;KOG3701,TGFbeta receptor signaling protein SMAD and related proteins","GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0003677,molecular_function,DNA binding;GO:0060395,biological_process,SMAD protein signal transduction;GO:0005667,cellular_component,transcription factor complex;GO:0005737,cellular_component,cytoplasm;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0001657,biological_process,ureteric bud development;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030902,biological_process,hindbrain development;GO:0030509,biological_process,BMP signaling pathway;GO:0005654,cellular_component,nucleoplasm;GO:0005622,cellular_component,intracellular;GO:0030901,biological_process,midbrain development;GO:0005829,cellular_component,cytosol;GO:0060348,biological_process,bone development;GO:0006468,biological_process,protein phosphorylation;GO:0051216,biological_process,cartilage development;GO:0006351,biological_process,transcription, DNA-templated","-"]
["RP11-600F24.7",0.818223489,0,6.608567071,1.262548729,0.000667207,0.001675357,"ENSG00000260285","Q6ZNT3,cDNA FLJ27206 fis, clone SYN03441","-","-","-","-","-","-"]
["RP1-59D14.1",3.121541816,0,6.608567071,1.262548729,0.000667207,0.001675357,"-","-","-","-","-","-","-","-"]
["CTB-175E5.7",6.296291731,0,6.608567071,1.262548729,0.000667207,0.001675357,"-","-","-","-","-","-","-","-"]
["KLHL7-AS1",1.296584257,0,6.608567071,1.262548729,0.000667207,0.001675357,"ENSG00000230658","H2RG68,Tigger transposable element derived 1","XP_016806199.1,tigger transposable element-derived protein 1","PF03184,superfamily endonuclease;PF03221,Tc5 transposase DNA-binding domain;PF04218,CENP-B N-terminal DNA-binding domain","IPR006600,HTH CenpB-type DNA-binding domain;IPR009057,Homeobox-like domain superfamily;IPR007889,DNA binding HTH domain, Psq-type;IPR004875,DDE superfamily endonuclease domain","ENOG4110CDI,-;KOG3105,DNA-binding centromere protein B (CENP-B)","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["TBX20",1.773035751,0,6.608567071,1.262548729,0.000667207,0.001675357,"ENSG00000164532","H2QUF0,T-box 20","XP_522453.3,-","PF00907,T-box","IPR001699,Transcription factor, T-box;IPR036960,T-box superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR018186,Transcription factor, T-box, conserved site","KOG3586,TBX1 and related T-box transcription factors;ENOG410Y98J,-","GO:0003175,biological_process,tricuspid valve development;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0009953,biological_process,dorsal/ventral pattern formation;GO:0006351,biological_process,transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0035050,biological_process,embryonic heart tube development;GO:0005737,cellular_component,cytoplasm;GO:0035922,biological_process,foramen ovale closure;GO:0036306,biological_process,embryonic heart tube elongation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0008015,biological_process,blood circulation;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003279,biological_process,cardiac septum development;GO:0003272,biological_process,endocardial cushion formation;GO:0001764,biological_process,neuron migration;GO:0003176,biological_process,aortic valve development;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0060045,biological_process,positive regulation of cardiac muscle cell proliferation;GO:0001947,biological_process,heart looping;GO:0001569,biological_process,branching involved in blood vessel morphogenesis;GO:0003148,biological_process,outflow tract septum morphogenesis;GO:0003193,biological_process,pulmonary valve formation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0021524,biological_process,visceral motor neuron differentiation;GO:0003180,biological_process,aortic valve morphogenesis;GO:0010991,biological_process,negative regulation of SMAD protein complex assembly;GO:0003344,biological_process,pericardium morphogenesis;GO:0001085,molecular_function,RNA polymerase II transcription factor binding;GO:0060413,biological_process,atrial septum morphogenesis;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001102,molecular_function,RNA polymerase II activating transcription factor binding;GO:0055008,biological_process,cardiac muscle tissue morphogenesis;GO:0003151,biological_process,outflow tract morphogenesis;GO:0060577,biological_process,pulmonary vein morphogenesis;GO:0008283,biological_process,cell proliferation;GO:0003215,biological_process,cardiac right ventricle morphogenesis;GO:0003203,biological_process,endocardial cushion morphogenesis;GO:0003143,biological_process,embryonic heart tube morphogenesis;GO:0003207,biological_process,cardiac chamber formation;GO:0001105,molecular_function,RNA polymerase II transcription coactivator activity;GO:0006936,biological_process,muscle contraction","-"]
["NR1I3",0.934033854,0,6.502788664,1.182679536,0.001268294,0.002986634,"ENSG00000143257","G1RVZ1,Nuclear receptor subfamily 1 group I member 3","XP_012366614.1,nuclear receptor subfamily 1 group I member 3 isoform X1","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR001628,Zinc finger, nuclear hormone receptor-type;IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR013088,Zinc finger, NHR/GATA-type","KOG3575,FOG: Hormone receptors;ENOG410XRZC,-","GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway","-"]
["DNM3",0.27248494,0,6.502788664,1.182679536,0.001268294,0.002986634,"ENSG00000197959","A0A0D9RGW8,Dynamin 3","XP_007987691.1,-","PF00350,ynamin family;PF01031,ynamin central region;PF02212,ynamin GTPase effector domain;PF00169,PH domain","IPR019762,Dynamin, GTPase region, conserved site;IPR000375,Dynamin central domain;IPR020850,GTPase effector domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR030381,Dynamin-type guanine nucleotide-binding (G) domain;IPR011993,PH-like domain superfamily;IPR022812,Dynamin superfamily;IPR003130,Dynamin GTPase effector;IPR001849,Pleckstrin homology domain;IPR001401,Dynamin, GTPase domain","-","GO:0016185,biological_process,synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0005525,molecular_function,GTP binding;GO:0005739,cellular_component,mitochondrion;GO:0003924,molecular_function,GTPase activity;GO:0045202,cellular_component,synapse;GO:0001917,cellular_component,photoreceptor inner segment;GO:0000166,molecular_function,nucleotide binding","-"]
["AP003068.9",5.67459906,0,6.502788664,1.182679536,0.001268294,0.002986634,"ENSG00000254501","F1M4I4,VPS51 GARP complex subunit","-","PF08700,Vps51/Vps67","IPR014812,Vacuolar protein sorting-associated protein 51;IPR016159,Cullin repeat-like-containing domain superfamily","KOG2346,Uncharacterized conserved protein;ENOG410XPIF,-","GO:0005802,cellular_component,trans-Golgi network;GO:0005794,cellular_component,Golgi apparatus;GO:0000938,cellular_component,GARP complex;GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0048193,biological_process,Golgi vesicle transport;GO:0016020,cellular_component,membrane;GO:0005515,molecular_function,protein binding;GO:1990745,cellular_component,EARP complex;GO:0006914,biological_process,autophagy;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0007041,biological_process,lysosomal transport;GO:0005730,cellular_component,nucleolus;GO:0007030,biological_process,Golgi organization;GO:0055037,cellular_component,recycling endosome;GO:0005829,cellular_component,cytosol;GO:0032456,biological_process,endocytic recycling;GO:0016021,cellular_component,integral component of membrane","-"]
["TMEM63C",0.485145669,0,6.502788664,1.182679536,0.001268294,0.002986634,"ENSG00000165548","A0A024R6B3,Transmembrane protein 63C, isoform CRA_a","NP_065164.2,calcium permeable stress-gated cation channel 1","PF14703,Cytosolic domain of 10TM putative phosphate transporter;PF02714,Calcium-dependent channel, 7TM region, putative phosphate;PF13967,Late exocytosis, associated with Golgi transport","IPR003864,Calcium-dependent channel, 7TM region, putative phosphate;IPR027815,10TM putative phosphate transporter, cytosolic domain;IPR032880,Calcium permeable stress-gated cation channel 1, N-terminal transmembrane domain","COG5594,Uncharacterized integral membrane protein;KOG1134,Uncharacterized conserved protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-66B24.8",5.473372143,0,6.502788664,1.182679536,0.001268294,0.002986634,"ENSG00000272639","Q3KRG0,Hypothetical LOC145757","-","-","-","-","-","-"]
["OSBPL7",0.469717269,0,6.502788664,1.182679536,0.001268294,0.002986634,"ENSG00000006025","Q8WXP9,Oxysterol-binding protein","NP_665741.1,oxysterol-binding protein-related protein 7","PF15409,Pleckstrin homology domain;PF01237,Oxysterol-binding protein","IPR000648,Oxysterol-binding protein;IPR037239,Oxysterol-binding protein superfamily;IPR001849,Pleckstrin homology domain;IPR018494,Oxysterol-binding protein, conserved site;IPR011993,PH-like domain superfamily","KOG1737,Oxysterol-binding protein;ENOG410XP9E,-","GO:0006869,biological_process,lipid transport","-"]
["HOXB-AS1",1.980103841,0,6.502788664,1.182679536,0.001268294,0.002986634,"-","-","-","-","-","-","-","-"]
["CTB-152G17.6",1.166659822,0,6.502788664,1.182679536,0.001268294,0.002986634,"ENSG00000272918","H2PFS8,Uncharacterized protein","-","-","-","-","-","-"]
["FAAH2",1.52896577,0,6.502788664,1.182679536,0.001268294,0.002986634,"ENSG00000165591","B2C6G4,Fatty acid amide hydrolase 2","NP_777572.2,fatty-acid amide hydrolase 2 isoform 1","PF01425,Amidase","IPR023631,Amidase signature domain;IPR036928,Amidase signature (AS) superfamily;IPR020556,Amidase, conserved site","KOG1212,Amidases;COG0154,Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases","GO:0016787,molecular_function,hydrolase activity","-"]
["MAMLD1",0.518123848,0,6.502788664,1.182679536,0.001268294,0.002986634,"ENSG00000013619","G3RKK4,Mastermind like domain containing 1","-","-","IPR026131,Mastermind-like domain-containing protein 1","-","-","-"]
["MKNK1-AS1",1.165448566,0,6.38863658,1.097898776,0.001268294,0.002986634,"ENSG00000269956","Q6ZP20,cDNA FLJ26702 fis, clone PCD01871","-","-","-","-","-","-"]
["DKFZP434K028",0.986334975,0,6.38863658,1.097898776,0.001268294,0.002986634,"ENSG00000124915","Q9UFL8,HCG2017874","-","-","-","-","-","-"]
["RP11-996F15.2",1.012983201,0,6.38863658,1.097898776,0.001268294,0.002986634,"ENSG00000257176","A0A096MWP3,Fatty acyl-CoA reductase","-","PF02719,Polysaccharide biosynthesis protein;PF01073,3-beta hydroxysteroid dehydrogenase/isomerase family;PF03015,Male sterility protein;PF07993,Male sterility protein;PF01370,NAD dependent epimerase/dehydratase family","-","-","-","-"]
["RP11-454F8.3",5.190385689,0,6.38863658,1.097898776,0.001268294,0.002986634,"-","-","-","-","-","-","-","-"]
["RP11-697E22.2",2.602302962,0,6.38863658,1.097898776,0.001268294,0.002986634,"ENSG00000277501","G1QRG6,DExD-box helicase 52","XP_003278445.1,probable ATP-dependent RNA helicase DDX52","PF00271,Helicase conserved C-terminal domain;PF00270,AD/DEAH box helicase","IPR011545,DEAD/DEAH box helicase domain;IPR014014,RNA helicase, DEAD-box type, Q motif;IPR001650,Helicase, C-terminal;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0344,ATP-dependent RNA helicase;ENOG410XQS8,-","GO:0003676,molecular_function,nucleic acid binding;GO:0005524,molecular_function,ATP binding","-"]
["ZNF792",0.673009387,0,6.38863658,1.097898776,0.001268294,0.002986634,"ENSG00000180884","H2QG14,Uncharacterized protein","XP_524215.2,zinc finger protein 792","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0042802,molecular_function,identical protein binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["AC098614.2",1.162121429,0,6.38863658,1.097898776,0.001268294,0.002986634,"ENSG00000213846","Q6ZSR7,cDNA FLJ45255 fis, clone BRHIP2015153","-","-","-","-","-","-"]
["USP46-AS1",2.719009297,0,6.38863658,1.097898776,0.001268294,0.002986634,"-","-","-","-","-","-","-","-"]
["APBA1",0.250309359,0,6.38863658,1.097898776,0.001268294,0.002986634,"ENSG00000107282","H2QXC2,Uncharacterized protein","XP_009454976.1,-;XP_001138890.1,amyloid beta A4 precursor protein-binding family A member 1 isoform X1","PF00640,Phosphotyrosine interaction domain (PTB/PID);PF00595,PDZ domain (Also known as DHR or GLGF)","IPR030530,Amyloid beta A4 precursor protein-binding family A member 1;IPR011993,PH-like domain superfamily;IPR036034,PDZ superfamily;IPR006020,PTB/PI domain;IPR001478,PDZ domain","ENOG410XSBD,-;KOG3605,Beta amyloid precursor-binding protein","GO:0014051,biological_process,gamma-aminobutyric acid secretion;GO:0005794,cellular_component,Golgi apparatus;GO:0014047,biological_process,glutamate secretion;GO:0007268,biological_process,chemical synaptic transmission;GO:0016020,cellular_component,membrane;GO:0035264,biological_process,multicellular organism growth;GO:0010468,biological_process,regulation of gene expression;GO:0001701,biological_process,in utero embryonic development;GO:0001540,molecular_function,amyloid-beta binding;GO:0008021,cellular_component,synaptic vesicle;GO:0007626,biological_process,locomotory behavior;GO:0006886,biological_process,intracellular protein transport","-"]
["ROR2",0.489776855,0,6.38863658,1.097898776,0.001268294,0.002986634,"ENSG00000169071","A1L4F5,Receptor tyrosine kinase-like orphan receptor 2","-","PF01392,z domain;PF00051,Kringle domain;PF07714,Protein tyrosine kinase;PF07679,Immunoglobulin I-set domain","IPR000719,Protein kinase domain;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR000001,Kringle;IPR036790,Frizzled cysteine-rich domain superfamily;IPR038178,Kringle superfamily;IPR020067,Frizzled domain;IPR013806,Kringle-like fold;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR008266,Tyrosine-protein kinase, active site;IPR007110,Immunoglobulin-like domain;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set;IPR018056,Kringle, conserved site;IPR011009,Protein kinase-like domain superfamily;IPR016247,Tyrosine-protein kinase, receptor ROR","KOG1026,Nerve growth factor receptor TRKA and related tyrosine kinases;ENOG410YGKQ,-","GO:0005515,molecular_function,protein binding;GO:0016301,molecular_function,kinase activity;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0016021,cellular_component,integral component of membrane","-"]
["GJB4",0.919739999,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000189433","G3R0R2,Gap junction protein","XP_004025472.1,gap junction beta-4 protein","PF00029,Connexin","IPR017990,Connexin, conserved site;IPR002270,Gap junction beta-4 protein (Cx31.1);IPR013092,Connexin, N-terminal;IPR019570,Gap junction protein, cysteine-rich domain;IPR038359,Connexin, N-terminal domain superfamily;IPR000500,Connexin","-","GO:0030054,cellular_component,cell junction;GO:0005921,cellular_component,gap junction;GO:0005730,cellular_component,nucleolus;GO:0007608,biological_process,sensory perception of smell;GO:0005922,cellular_component,connexin complex;GO:0007154,biological_process,cell communication;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0042048,biological_process,olfactory behavior;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","-"]
["RP11-21L23.2",0.623106297,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000261578","Q6ZSR7,cDNA FLJ45255 fis, clone BRHIP2015153","-","-","-","-","-","-"]
["DNAH10",0.15622378,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000197653","A0A1C7CYW8,Dynein heavy chain 10, axonemal","-","PF12774,Hydrolytic ATP binding site of dynein motor region D1;PF12777,Microtubule-binding stalk of dynein motor;PF07728,AAA domain (dynein-related subfamily);PF03028,ynein heavy chain and region D6 of dynein motor;PF12780,P-loop containing dynein motor region D4;PF08393,ynein heavy chain, N-terminal region 2;PF08385,ynein heavy chain, N-terminal region 1;PF12781,ATP-binding dynein motor region D5;PF12775,P-loop containing dynein motor region D3","IPR035699,Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;IPR024743,Dynein heavy chain, coiled coil stalk;IPR026983,Dynein heavy chain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004273,Dynein heavy chain domain;IPR013602,Dynein heavy chain, domain-2;IPR035706,Dynein heavy chain, ATP-binding dynein motor region D5;IPR011704,ATPase, dynein-related, AAA domain;IPR003593,AAA+ ATPase domain;IPR013594,Dynein heavy chain, domain-1;IPR024317,Dynein heavy chain, AAA module D4","-","GO:0007018,biological_process,microtubule-based movement;GO:0030286,cellular_component,dynein complex;GO:0016887,molecular_function,ATPase activity;GO:0003777,molecular_function,microtubule motor activity;GO:0005524,molecular_function,ATP binding","-"]
["RP11-57A19.2",1.052826118,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000246465","G7PXF9,Uncharacterized protein","-","-","-","-","-","-"]
["ITFG1-AS1",4.172622361,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000260281","A0A1U7THJ7,T-cell immunomodulatory protein","XP_008053211.1,-","-","IPR024881,T-cell immunomodulatory protein","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CCL22",0.891792966,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000102962","G3QZ89,C-C motif chemokine","-","PF00048,Small cytokines (intecrine/chemokine), interleukin-8 like","-","-","-","-"]
["CTRL",0.962085303,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000141086","Q8IUW0,CTRL protein","-","PF00089,Trypsin","IPR001254,Serine proteases, trypsin domain;IPR018114,Serine proteases, trypsin family, histidine active site;IPR001314,Peptidase S1A, chymotrypsin family;IPR009003,Peptidase S1, PA clan;IPR033116,Serine proteases, trypsin family, serine active site","KOG3627,Trypsin;COG5640,Secreted trypsin-like serine protease","GO:0008236,molecular_function,serine-type peptidase activity;GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0008233,molecular_function,peptidase activity","-"]
["ALOX12",0.998494495,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000108839","G3R2S7,Arachidonate 12-lipoxygenase, 12S type","XP_004058489.1,arachidonate 12-lipoxygenase, 12S-type","PF00305,Lipoxygenase;PF01477,PLAT/LH2 domain","IPR020834,Lipoxygenase, conserved site;IPR036392,PLAT/LH2 domain superfamily;IPR001024,PLAT/LH2 domain;IPR036226,Lipoxigenase, C-terminal domain superfamily;IPR020833,Lipoxygenase, iron binding site;IPR013819,Lipoxygenase, C-terminal;IPR001885,Lipoxygenase, mammalian;IPR000907,Lipoxygenase","-","GO:0051213,molecular_function,dioxygenase activity;GO:0046872,molecular_function,metal ion binding;GO:0016491,molecular_function,oxidoreductase activity;GO:0005506,molecular_function,iron ion binding;GO:0055114,biological_process,oxidation-reduction process;GO:0016702,molecular_function,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen","-"]
["AF127577.10",4.647796438,0,6.264670196,1.007565613,0.002421289,0.005369716,"-","-","-","-","-","-","-","-"]
["RP11-308B16.2",7.021670963,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000248783","G7PC85,Uncharacterized protein","-","-","-","-","-","-"]
["BNC2",0.170466723,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000173068","H2R6S5,Basonuclin 2","XP_520498.2,zinc finger protein basonuclin-2 isoform X4","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type","IPR013087,Zinc finger C2H2-type","ENOG410IE3V,-;ENOG410YN2D,-","GO:0060485,biological_process,mesenchyme development;GO:0003677,molecular_function,DNA binding;GO:0060021,biological_process,roof of mouth development;GO:0003416,biological_process,endochondral bone growth;GO:0003676,molecular_function,nucleic acid binding;GO:0005654,cellular_component,nucleoplasm;GO:0005634,cellular_component,nucleus;GO:0043586,biological_process,tongue development","-"]
["RP11-345P4.9",1.165162636,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000272106","Q6ZTL7,cDNA FLJ44537 fis, clone UTERU3005049","-","-","-","-","-","-"]
["RP11-867G23.8",1.541948995,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000255468","F7I026,Uncharacterized protein","-","-","-","-","-","-"]
["NAV3",0.195682032,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000067798","G1QYL8,Neuron navigator 3","XP_003259631.1,neuron navigator 3 isoform X1","PF00004,ATPase family associated with various cellular activities (AAA);PF00307,Calponin homology (CH) domain","IPR003959,ATPase, AAA-type, core;IPR001715,Calponin homology domain;IPR003593,AAA+ ATPase domain;IPR036872,CH domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410IGVF,-;ENOG410XRG8,-","GO:1905929,biological_process,positive regulation of invadopodium disassembly;GO:1990752,cellular_component,microtubule end;GO:0007026,biological_process,negative regulation of microtubule depolymerization;GO:0032703,biological_process,negative regulation of interleukin-2 production;GO:0031116,biological_process,positive regulation of microtubule polymerization;GO:0008017,molecular_function,microtubule binding;GO:0005524,molecular_function,ATP binding;GO:0030336,biological_process,negative regulation of cell migration","-"]
["RP11-380N8.7",5.117675545,0,6.129041833,0.910905805,0.004642655,0.009589815,"-","-","-","-","-","-","-","-"]
["CCDC169",0.268711265,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000242715","F6RGK2,Uncharacterized protein","-","PF15372,omain of unknown function (DUF4600)","IPR028022,Protein of unknown function DUF4600","ENOG4111UKE,-;ENOG410IWC3,-","-","-"]
["RP11-461A8.1",7.217633595,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000261938","G3RKC9,SLX4 structure-specific endonuclease subunit","XP_018868364.1,structure-specific endonuclease subunit SLX4 isoform X1","PF09494,Slx4 endonuclease;PF00651,BTB/POZ domain","IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily;IPR018574,Structure-specific endonuclease subunit Slx4","-","GO:0006281,biological_process,DNA repair;GO:0006260,biological_process,DNA replication;GO:0033557,cellular_component,Slx1-Slx4 complex;GO:0005634,cellular_component,nucleus;GO:0017108,molecular_function,5'-flap endonuclease activity","-"]
["RP11-77K12.5",2.860965606,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000262583","H2RAT2,Uncharacterized protein","-","PF10149,Transmembrane protein 231","IPR019306,Transmembrane protein 231","KOG4838,Uncharacterized conserved protein;ENOG410XQ0K,-","GO:0060170,cellular_component,ciliary membrane;GO:0032880,biological_process,regulation of protein localization;GO:0035869,cellular_component,ciliary transition zone;GO:0043010,biological_process,camera-type eye development;GO:0007224,biological_process,smoothened signaling pathway;GO:0060563,biological_process,neuroepithelial cell differentiation;GO:0001701,biological_process,in utero embryonic development;GO:0042733,biological_process,embryonic digit morphogenesis;GO:0016020,cellular_component,membrane;GO:0001944,biological_process,vasculature development;GO:0060271,biological_process,cilium assembly;GO:0036038,cellular_component,MKS complex;GO:0016021,cellular_component,integral component of membrane","-"]
["SGSM1",0.275891885,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000167037","H2RCJ4,Uncharacterized protein","XP_016802775.1,-;XP_001171406.1,small G protein signaling modulator 1 isoform X1","PF00566,Rab-GTPase-TBC domain;PF02759,RUN domain","IPR000195,Rab-GTPase-TBC domain;IPR035969,Rab-GTPase-TBC domain superfamily;IPR037213,RUN domain superfamily;IPR037745,Small G protein signaling modulator 1/2, PH domain;IPR004012,RUN domain","KOG1648,Uncharacterized conserved protein, contains RUN, BRK and TBC domains;COG5210,GTPase-activating protein","GO:0012505,cellular_component,endomembrane system;GO:0017137,molecular_function,Rab GTPase binding;GO:0005096,molecular_function,GTPase activator activity;GO:0090630,biological_process,activation of GTPase activity;GO:0031338,biological_process,regulation of vesicle fusion;GO:0005622,cellular_component,intracellular;GO:0006886,biological_process,intracellular protein transport","-"]
["MAP6D1",0.986130171,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000180834","K7ANA0,MAP6 domain containing 1","-","-","-","-","-","-"]
["CLIC5",0.263932583,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000112782","G3RBM4,Chloride intracellular channel protein","XP_004044177.1,chloride intracellular channel protein 5 isoform X1","PF13410,lutathione S-transferase, C-terminal domain;PF13417,lutathione S-transferase, N-terminal domain","IPR002946,Intracellular chloride channel;IPR036249,Thioredoxin-like superfamily;IPR036282,Glutathione S-transferase, C-terminal domain superfamily;IPR010987,Glutathione S-transferase, C-terminal-like;IPR004045,Glutathione S-transferase, N-terminal;IPR030264,Chloride intracellular channel protein 5","-","GO:1902476,biological_process,chloride transmembrane transport;GO:0006821,biological_process,chloride transport;GO:0034707,cellular_component,chloride channel complex;GO:0005737,cellular_component,cytoplasm;GO:0015629,cellular_component,actin cytoskeleton;GO:0007605,biological_process,sensory perception of sound;GO:0005254,molecular_function,chloride channel activity;GO:0006811,biological_process,ion transport;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0016020,cellular_component,membrane;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0034220,biological_process,ion transmembrane transport","-"]
["PDE7B",0.399361159,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000171408","Q4LE81,Phosphodiesterase","-","PF00233,3'5'-cyclic nucleotide phosphodiesterase","IPR003607,HD/PDEase domain;IPR023088,3'5'-cyclic nucleotide phosphodiesterase;IPR023174,3'5'-cyclic nucleotide phosphodiesterase, conserved site;IPR002073,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain;IPR036971,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily","ENOG410XRI7,-;KOG3689,Cyclic nucleotide phosphodiesterase","GO:0007165,biological_process,signal transduction;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0004114,molecular_function,3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0016787,molecular_function,hydrolase activity;GO:0046872,molecular_function,metal ion binding","-"]
["RP11-479O9.4",1.210296357,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000272693","Q6NXN2,Hypothetical LOC441242","-","-","-","-","-","-"]
["LMLN-AS1",42.93559822,0.604545102,6.008203943,3.690155452,{"v":6.03e-17,"d":"6.03E-17"},{"v":2.78e-15,"d":"2.78E-15"},"ENSG00000232832","H2QP23,Leishmanolysin like peptidase","-","PF01457,Leishmanolysin","IPR001577,Peptidase M8, leishmanolysin","ENOG410XSAG,-;KOG2556,Leishmanolysin-like peptidase (Peptidase M8 family)","GO:0006508,biological_process,proteolysis;GO:0007155,biological_process,cell adhesion;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MCOLN3",0.322684781,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000055732","G3QWU1,Mucolipin 3","XP_018871751.1,mucolipin-3","PF08016,Polycystin cation channel","IPR013122,Polycystin cation channel, PKD1/PKD2","-","GO:0005737,cellular_component,cytoplasm;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0007626,biological_process,locomotory behavior;GO:0042491,biological_process,inner ear auditory receptor cell differentiation","-"]
["RP11-755F10.1",5.383227475,0,5.979327299,0.806972016,0.00894141,0.017239021,"-","-","-","-","-","-","-","-"]
["GDPD5",0.216594842,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000158555","A0A024R5K7,Glycerophosphodiester phosphodiesterase domain containing 5, isoform CRA_a","-","PF03009,lycerophosphoryl diester phosphodiesterase family","IPR030395,Glycerophosphodiester phosphodiesterase domain;IPR004129,Glycerophosphoryl diester phosphodiesterase;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily","KOG2258,Glycerophosphoryl diester phosphodiesterase;COG0584,Glycerophosphoryl diester phosphodiesterase","GO:0008889,molecular_function,glycerophosphodiester phosphodiesterase activity;GO:0006629,biological_process,lipid metabolic process;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-110I1.6",3.204109906,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000255114","A0A0P6CVN8,Uncharacterized protein","-","-","-","-","-","-"]
["RP11-299G20.2",0.825151084,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000259172","F7ILB5,Uncharacterized protein","-","-","-","ENOG410YZ90,-;ENOG410JFAY,-","-","-"]
["MTCO1P40",3.419426092,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000262902","B2XI93,Cytochrome c oxidase subunit 1","-","PF00115,Cytochrome C and Quinol oxidase polypeptide I","IPR036927,Cytochrome c oxidase-like, subunit I  superfamily;IPR023615,Cytochrome c oxidase, subunit I, copper-binding site;IPR000883,Cytochrome c oxidase subunit I;IPR033944,Cytochrome c oxidase subunit I domain;IPR023616,Cytochrome c oxidase-like, subunit I domain","KOG4769,Cytochrome c oxidase, subunit I;COG0843,Heme/copper-type cytochrome/quinol oxidases, subunit 1","GO:0022900,biological_process,electron transport chain;GO:0006119,biological_process,oxidative phosphorylation;GO:1902600,biological_process,proton transmembrane transport;GO:0005506,molecular_function,iron ion binding;GO:0016020,cellular_component,membrane;GO:0004129,molecular_function,cytochrome-c oxidase activity;GO:0046872,molecular_function,metal ion binding;GO:0009055,molecular_function,electron transfer activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0009060,biological_process,aerobic respiration;GO:0045277,cellular_component,respiratory chain complex IV;GO:0005739,cellular_component,mitochondrion;GO:0070469,cellular_component,respiratory chain;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0020037,molecular_function,heme binding;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane","-"]
["CTD-2561B21.5",0.507996508,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000261924","Q6ZRW6,cDNA FLJ46026 fis, clone SPLEN2024571","-","-","-","-","-","-"]
["PSG9",0.423363967,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000183668","Q6LEU7,PSG9 protein","-","PF07686,Immunoglobulin V-set domain;PF13895,Immunoglobulin domain","IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain","ENOG410JG1N,-;ENOG410YTW2,-","-","-"]
["CTC-444N24.7",1.54083728,0,5.979327299,0.806972016,0.00894141,0.017239021,"-","-","-","-","-","-","-","-"]
["FBXO36",0.541734172,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000153832","H2R622,F-box protein 36","-","PF00646,-box domain","IPR036047,F-box-like domain superfamily;IPR001810,F-box domain","ENOG4111P01,-;ENOG410IPEE,-","-","-"]
["TUG1_1",14.73890557,0,5.979327299,0.806972016,0.00894141,0.017239021,"-","-","-","-","-","-","-","-"]
["SLC15A2",0.344145138,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000163406","Q86UE9,Solute carrier family 15","-","PF00854,POT family","IPR029028,Alpha/beta knot methyltransferases;IPR004768,Oligopeptide transporter;IPR020846,Major facilitator superfamily domain;IPR018456,PTR2 family proton/oligopeptide symporter, conserved site;IPR036259,MFS transporter superfamily;IPR000109,Proton-dependent oligopeptide transporter family","KOG1237,H+/oligopeptide symporter;COG3104,Dipeptide/tripeptide permease","GO:0022857,molecular_function,transmembrane transporter activity;GO:0055085,biological_process,transmembrane transport;GO:0006857,biological_process,oligopeptide transport;GO:0035672,biological_process,oligopeptide transmembrane transport;GO:0016020,cellular_component,membrane;GO:0035673,molecular_function,oligopeptide transmembrane transporter activity;GO:0005215,molecular_function,transporter activity;GO:0016021,cellular_component,integral component of membrane","-"]
["RP11-428J1.5",1.435286305,0,5.979327299,0.806972016,0.00894141,0.017239021,"-","-","-","-","-","-","-","-"]
["MIR6835",33.39283293,0,5.979327299,0.806972016,0.00894141,0.017239021,"-","-","-","-","-","-","-","-"]
["EEPD1",0.440920427,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000122547","G3QR97,Endonuclease/exonuclease/phosphatase family domain containing 1","XP_004045357.1,-","PF12836,Helix-hairpin-helix motif","IPR003583,Helix-hairpin-helix DNA-binding motif, class 1;IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR010994,RuvA domain 2-like;IPR004509,Competence protein ComEA, helix-hairpin-helix domain","-","GO:0006281,biological_process,DNA repair;GO:0003677,molecular_function,DNA binding","-"]
["ST7-AS2",0.745687825,0,5.979327299,0.806972016,0.00894141,0.017239021,"-","-","-","-","-","-","-","-"]
["GIMAP2",1.019142254,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000106560","A0A090N8H4,GTPase, IMAP family member 2, isoform CRA_c","NP_056475.1,GTPase IMAP family member 2","PF04548,AIG1 family","IPR006703,AIG1-type guanine nucleotide-binding (G) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410Y0H9,-;ENOG410J90P,-","GO:0005525,molecular_function,GTP binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP4-758J18.7",3.498492012,0,5.8122579,0.694588199,0.017297867,0.030736627,"-","-","-","-","-","-","-","-"]
["TCEA3",0.540449833,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000204219","H2R320,Transcription elongation factor A","XP_513192.4,-","PF08711,TFIIS helical bundle-like domain;PF07500,Transcription factor S-II (TFIIS), central domain;PF01096,Transcription factor S-II (TFIIS)","IPR001222,Zinc finger, TFIIS-type;IPR035441,TFIIS/LEDGF domain superfamily;IPR017923,Transcription factor IIS, N-terminal;IPR036575,Transcription elongation factor S-II, central domain superfamily;IPR006289,Transcription elongation factor, TFIIS;IPR035100,Transcription elongation factor, IIS-type;IPR003618,Transcription elongation factor S-II, central domain;IPR003617,Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type","COG1594,DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS;KOG1105,Transcription elongation factor TFIIS/Cofactor of enhancer-binding protein Sp1","GO:0003746,molecular_function,translation elongation factor activity;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006414,biological_process,translational elongation;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0006351,biological_process,transcription, DNA-templated","-"]
["AC245100.1",1.795539851,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000280649","B9EK34,Uncharacterized protein","-","-","-","ENOG4111A5N,-;ENOG410JBYT,-","-","-"]
["TNNT2",0.261700119,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000118194","F7HC43,Troponin T2, cardiac type","-","PF00992,Troponin","IPR038077,Troponin domain superfamily;IPR001978,Troponin;IPR027707,Troponin T","KOG3634,Troponin;ENOG410XS6A,-","GO:0031013,molecular_function,troponin I binding;GO:0006937,biological_process,regulation of muscle contraction;GO:0005523,molecular_function,tropomyosin binding;GO:0097512,cellular_component,cardiac myofibril;GO:0032780,biological_process,negative regulation of ATPase activity;GO:0005865,cellular_component,striated muscle thin filament;GO:0051592,biological_process,response to calcium ion;GO:1990584,cellular_component,cardiac Troponin complex;GO:0055010,biological_process,ventricular cardiac muscle tissue morphogenesis;GO:0005861,cellular_component,troponin complex;GO:0032781,biological_process,positive regulation of ATPase activity;GO:0003779,molecular_function,actin binding;GO:0060048,biological_process,cardiac muscle contraction;GO:0030172,molecular_function,troponin C binding;GO:0030049,biological_process,muscle filament sliding;GO:0008016,biological_process,regulation of heart contraction","-"]
["LRRC37A6P",0.337721096,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000230445","H2RHT2,Uncharacterized protein","-","PF14914,LRRC37A/B like protein 1 C-terminal domain;PF13855,Leucine rich repeat;PF15779,Leucine-rich repeat-containing protein 37 family","IPR001611,Leucine-rich repeat;IPR032754,Leucine-rich repeat-containing protein 37, N-terminal;IPR032675,Leucine-rich repeat domain superfamily;IPR029423,LRRC37A/B like protein 1, C-terminal;IPR003591,Leucine-rich repeat, typical subtype;IPR015753,Leucine-rich repeat-containing protein 37","ENOG410YV94,-;ENOG410IJNR,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["LINC00858",0.659840626,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000229404","A0A146U7E7,HCG1984907","-","-","-","-","-","-"]
["BMS1P3",2.038284509,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000240089","F1RG23,BMS1, ribosome biogenesis factor","-","PF04950,40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal","IPR037875,Ribosome biogenesis protein Bms1, N-terminal;IPR007034,Ribosome biogenesis protein BMS1/TSR1, C-terminal;IPR030387,Bms1/Tsr1-type G domain;IPR012948,AARP2CN;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG1951,GTP-binding protein AARP2 involved in 40S ribosome biogenesis;COG5192,GTP-binding protein required for 40S ribosome biogenesis","GO:0005525,molecular_function,GTP binding;GO:0042254,biological_process,ribosome biogenesis;GO:0005634,cellular_component,nucleus","-"]
["ATE1-AS1",1.620888364,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000226864","H0XP96,Uncharacterized protein","-","-","-","ENOG410JAFR,-;ENOG4111CIY,-","-","-"]
["MIR7106",29.22586403,0,5.8122579,0.694588199,0.017297867,0.030736627,"-","-","-","-","-","-","-","-"]
["COL4A2-AS2",1.248147938,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000224821","Q6ZP31,cDNA FLJ26619 fis, clone MPB09660","NP_001253973.1,uncharacterized protein LOC100129836","-","-","-","-","-"]
["RP11-1103G16.1",1.138215196,0,5.8122579,0.694588199,0.017297867,0.030736627,"-","-","-","-","-","-","-","-"]
["RP11-48G14.2",0.770661729,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000259941","H0YLZ3,Testis-expressed protein 9","-","-","-","ENOG41102ZI,-;ENOG410IGT0,-","-","-"]
["RBPMS2",0.904179516,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000166831","H2Q9L2,RNA binding protein with multiple splicing 2","XP_001174270.1,RNA-binding protein with multiple splicing 2 isoform X1","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034787,RBPMS2, RNA recognition motif;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily","ENOG410XSBT,-;KOG1457,RNA binding protein (contains RRM repeats)","GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0051151,biological_process,negative regulation of smooth muscle cell differentiation;GO:0003723,molecular_function,RNA binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0003729,molecular_function,mRNA binding","-"]
["CTD-3065B20.3",2.354003919,0,5.8122579,0.694588199,0.017297867,0.030736627,"-","-","-","-","-","-","-","-"]
["RP11-419C5.2",1.099352524,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000226232","B7ZM90,Uncharacterized protein","-","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-505K9.4",0.621826894,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000260300","A0A087X1B8,Uncharacterized protein","-","PF05292,Malonyl-CoA decarboxylase C-terminal domain","IPR007956,Malonyl-CoA decarboxylase, C-terminal","KOG3018,Malonyl-CoA decarboxylase;COG1593,TRAP-type C4-dicarboxylate transport system, large permease component","GO:0006633,biological_process,fatty acid biosynthetic process;GO:0050080,molecular_function,malonyl-CoA decarboxylase activity","-"]
["RP11-314A20.5",3.957669088,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000261898","I3L2Q0,Mediator of RNA polymerase II transcription subunit 11","-","PF10280,Mediator complex protein","IPR019404,Mediator complex, subunit Med11","ENOG4111SCB,-;KOG4057,Uncharacterized conserved protein","GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0016592,cellular_component,mediator complex;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component,nucleus","-"]
["MFAP4",0.882751469,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000166482","K7ES70,Microfibril-associated glycoprotein 4","-","PF00147,ibrinogen beta and gamma chains, C-terminal globular domain","IPR002181,Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;IPR036056,Fibrinogen-like, C-terminal","KOG2579,Ficolin and related extracellular proteins;ENOG410ZYS4,-","-","-"]
["ZNF750",0.511629723,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000141579","G3QHX3,Zinc finger protein 750","XP_004040794.1,zinc finger protein 750","PF15269,Zinc-finger","-","-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0008544,biological_process,epidermis development;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001046,molecular_function,core promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["CBX3P2",1.329378,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000266405","G1KN19,Chromobox 3","XP_003222084.1,chromobox protein homolog 3 isoform X2","PF00385,Chromo (CHRromatin Organisation MOdifier) domain;PF01393,Chromo shadow domain","IPR023780,Chromo domain;IPR016197,Chromo-like domain superfamily;IPR008251,Chromo shadow domain;IPR023779,Chromo domain, conserved site;IPR017984,Chromo domain subgroup;IPR000953,Chromo/chromo shadow domain;IPR038033,Chromobox protein homolog 3","ENOG4111JKD,-;KOG1911,Heterochromatin-associated protein HP1 and related CHROMO domain proteins","GO:0019899,molecular_function,enzyme binding;GO:0000785,cellular_component,chromatin;GO:0005719,cellular_component,nuclear euchromatin;GO:0005819,cellular_component,spindle;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0019904,molecular_function,protein domain specific binding;GO:1990226,molecular_function,histone methyltransferase binding;GO:0000775,cellular_component,chromosome, centromeric region;GO:0005720,cellular_component,nuclear heterochromatin;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus","-"]
["WDR88",1.031874613,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000166359","G2HGP2,PQQ repeat and WD repeat domain-containing protein","NP_001233357.1,WD repeat-containing protein 88","PF00400,WD domain, G-beta repeat;PF01011,PQQ enzyme repeat","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR018391,Pyrrolo-quinoline quinone beta-propeller repeat;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat;IPR002372,Pyrrolo-quinoline quinone repeat","ENOG410XP3K,-;KOG0266,WD40 repeat-containing protein","-","-"]
["CEACAM6",0.622438127,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000086548","H2QGH0,Carcinoembryonic antigen related cell adhesion molecule 6","-","PF13927,Immunoglobulin domain;PF07686,Immunoglobulin V-set domain;PF13895,Immunoglobulin domain","-","-","-","-"]
["RALY-AS1",1.57388663,0,5.8122579,0.694588199,0.017297867,0.030736627,"-","-","-","-","-","-","-","-"]
["PAXBP1-AS1",0.469520801,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000238197","I7GC03,Macaca fascicularis brain cDNA clone: QflA-17923, similar to human protocadherin 11 X-linked","-","-","-","-","-","-"]
["LINC00885",1.03921289,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000224652","Q6ZPD5,cDNA FLJ25996 fis, clone DMC06615","-","-","-","-","-","-"]
["EPB41L4A-AS2",1.360803125,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000278921","Q9NUN8,HCG1658703","-","-","-","ENOG410JN2U,-;ENOG41112ZP,-","-","-"]
["SEMA6A",0.173391855,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000092421","A0A0A0MQU6,Sema domain, transmembrane domain","NP_001287709.1,semaphorin-6A isoform 1 precursor","PF01437,Plexin repeat;PF01403,Sema domain","IPR001627,Sema domain;IPR036352,Sema domain superfamily;IPR016201,PSI domain;IPR002165,Plexin repeat;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR027231,Semaphorin","KOG3611,Semaphorins;ENOG410XQZC,-","GO:0051642,biological_process,centrosome localization;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0071526,biological_process,semaphorin-plexin signaling pathway;GO:0007411,biological_process,axon guidance;GO:0030215,molecular_function,semaphorin receptor binding;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:2001224,biological_process,positive regulation of neuron migration;GO:0016020,cellular_component,membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0001764,biological_process,neuron migration","-"]
["AC005532.5",1.53571638,0,5.8122579,0.694588199,0.017297867,0.030736627,"-","-","-","-","-","-","-","-"]
["AC005281.1",0.758355753,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000226690","A0A1B0GVB3,Uncharacterized protein","-","-","-","-","-","-"]
["ST7-AS1",1.0056544,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000227199","F7E759,Suppression of tumorigenicity 7","-","PF04184,ST7 protein","IPR007311,ST7","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-12A20.7",2.900276584,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000274911","G3RPL7,Uncharacterized protein","-","PF15832,AM27 D and E protein family","-","-","-","-"]
["PNCK",0.373144994,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000130822","F7GKF1,Pregnancy up-regulated nonubiquitous CaM kinase","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0032,Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily;ENOG410XRMJ,-","GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0035556,biological_process,intracellular signal transduction;GO:0004683,molecular_function,calmodulin-dependent protein kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0005622,cellular_component,intracellular;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0018107,biological_process,peptidyl-threonine phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["OSTCP2",3.743741029,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000225294","H2RD97,Oligosaccharyltransferase complex subunit","XP_001137201.1,-;XP_009439788.1,-","PF04756,OST3 / OST6 family, transporter family","IPR021149,Oligosaccharyl transferase complex, subunit OST3/OST6","KOG3356,Predicted membrane protein;ENOG4111G0G,-","GO:0016740,molecular_function,transferase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZCCHC24",0.329087511,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000165424","A0A0D9RAE2,Zinc finger CCHC-type containing 24","XP_007961009.1,-","PF17180,Zinc-binding domain;PF13696,Zinc knuckle","IPR027377,Zinc-binding domain;IPR001878,Zinc finger, CCHC-type;IPR025829,Zinc knuckle CX2CX3GHX4C;IPR033446,Zinc finger domain-containing protein 24, zinc-binding domain;IPR036875,Zinc finger, CCHC-type superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0008270,molecular_function,zinc ion binding","-"]
["RP11-144G7.2",1.724295661,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["RP11-677M14.3",1.080767891,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["RP11-20D14.6",0.729364202,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000249790","Q8WYX4,Uncharacterized protein pp11662","-","-","-","-","-","-"]
["KCNH3",0.389735291,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000135519","B9EK44,Potassium voltage-gated channel, subfamily H","-","PF13426,PAS domain;PF00027,Cyclic nucleotide-binding domain;PF00520,Ion transport protein","IPR000014,PAS domain;IPR003950,Potassium channel, voltage-dependent, ELK;IPR000700,PAS-associated, C-terminal;IPR014710,RmlC-like jelly roll fold;IPR000595,Cyclic nucleotide-binding domain;IPR035965,PAS domain superfamily;IPR018490,Cyclic nucleotide-binding-like;IPR005821,Ion transport domain;IPR001610,PAC motif;IPR003938,Potassium channel, voltage-dependent, EAG/ELK/ERG","ENOG410XPSE,-;KOG0498,K+-channel ERG and related proteins, contain PAS/PAC sensor domain","GO:0005216,molecular_function,ion channel activity;GO:0005267,molecular_function,potassium channel activity;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0023014,biological_process,signal transduction by protein phosphorylation;GO:0000160,biological_process,phosphorelay signal transduction system;GO:0055085,biological_process,transmembrane transport;GO:0016020,cellular_component,membrane;GO:0005249,molecular_function,voltage-gated potassium channel activity;GO:0006811,biological_process,ion transport;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0000155,molecular_function,phosphorelay sensor kinase activity;GO:0005622,cellular_component,intracellular;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0006813,biological_process,potassium ion transport;GO:0016021,cellular_component,integral component of membrane","-"]
["B4GALNT1",0.20769974,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000135454","H2Q6B9,Beta-1,4 N-acetylgalactosaminyltransferase","XP_509169.2,beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X6","PF00535,lycosyl transferase family 2","IPR011143,Ganglioside GM2 synthase;IPR001173,Glycosyltransferase 2-like;IPR029044,Nucleotide-diphospho-sugar transferases","ENOG410IF61,-;ENOG4111N56,-","GO:0007283,biological_process,spermatogenesis;GO:0005794,cellular_component,Golgi apparatus;GO:0030259,biological_process,lipid glycosylation;GO:0001574,biological_process,ganglioside biosynthetic process;GO:0003947,molecular_function,(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0000139,cellular_component,Golgi membrane;GO:0006687,biological_process,glycosphingolipid metabolic process;GO:0016020,cellular_component,membrane;GO:0016758,molecular_function,transferase activity, transferring hexosyl groups;GO:0019915,biological_process,lipid storage;GO:0030173,cellular_component,integral component of Golgi membrane","-"]
["RP11-338K17.8",5.17825862,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["RP11-321C24.1",5.276892117,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["RPS4XP16",1.667222685,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000224892","G3RUZ2,40S ribosomal protein S4","XP_004064423.1,-","PF16121,40S ribosomal protein S4 C-terminus;PF01479,S4 domain;PF00467,KOW motif;PF08071,RS4NT (NUC023) domain;PF00900,Ribosomal family S4e","IPR000876,Ribosomal protein S4e;IPR018199,Ribosomal protein S4e, N-terminal, conserved site;IPR013843,Ribosomal protein S4e, N-terminal;IPR032277,40S ribosomal protein S4, C-terminal domain;IPR038237,Ribosomal protein S4e, central domain superfamily;IPR013845,Ribosomal protein S4e, central region;IPR002942,RNA-binding S4 domain;IPR005824,KOW;IPR014722,Ribosomal protein L2, domain 2","-","GO:0019843,molecular_function,rRNA binding;GO:0003735,molecular_function,structural constituent of ribosome;GO:0003723,molecular_function,RNA binding;GO:0005840,cellular_component,ribosome;GO:0005622,cellular_component,intracellular;GO:0006412,biological_process,translation;GO:0030529,,","-"]
["TMEM255B",0.228107728,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000184497","K7DRT1,Family with sequence similarity 70, member B","-","PF14967,AM70 protein","IPR028014,FAM70 protein","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["AL157871.2",8.069034063,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["LINC00052",0.845483732,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["CRTC3-AS1",1.736908064,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000259736","H2NP71,CREB regulated transcription coactivator 3","-","PF12886,Transducer of regulated CREB activity, C terminus;PF12885,Transducer of regulated CREB activity middle domain","IPR024785,Transducer of regulated CREB activity, C-terminal;IPR024784,Transducer of regulated CREB activity, middle domain;IPR024786,CREB-regulated transcription coactivator","ENOG410XPDQ,-;ENOG410IGNT,-","GO:0032793,biological_process,positive regulation of CREB transcription factor activity;GO:0005737,cellular_component,cytoplasm;GO:0050995,biological_process,negative regulation of lipid catabolic process;GO:0042116,biological_process,macrophage activation;GO:0043951,biological_process,negative regulation of cAMP-mediated signaling;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0005829,cellular_component,cytosol;GO:0097009,biological_process,energy homeostasis;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-1348G14.4",0.846775862,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000251417","F6YYL9,Uncharacterized protein","-","-","-","-","GO:0048741,biological_process,skeletal muscle fiber development","-"]
["ZNF843",0.364202677,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000176723","G1S2S2,Zinc finger protein 843","-","-","-","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","-","-"]
["RP11-77K12.9",0.650066882,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000274220","D2HY25,Uncharacterized protein","-","PF03184,superfamily endonuclease;PF03221,Tc5 transposase DNA-binding domain;PF04218,CENP-B N-terminal DNA-binding domain","IPR006600,HTH CenpB-type DNA-binding domain;IPR009057,Homeobox-like domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR004875,DDE superfamily endonuclease domain;IPR007889,DNA binding HTH domain, Psq-type","-","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["RP5-1142A6.2",0.346512616,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000224888","G1QIK9,Piezo-type mechanosensitive ion channel component","-","PF12166,Piezo non-specific cation channel, R-Ras-binding domain;PF15917,Piezo","IPR031805,Piezo domain;IPR027272,Piezo family;IPR031334,Piezo non-specific cation channel, R-Ras-binding domain","KOG1893,Uncharacterized conserved protein;ENOG410YVF6,-","GO:0033625,biological_process,positive regulation of integrin activation;GO:0055085,biological_process,transmembrane transport;GO:0005783,cellular_component,endoplasmic reticulum;GO:0033634,biological_process,positive regulation of cell-cell adhesion mediated by integrin;GO:0008381,molecular_function,mechanosensitive ion channel activity;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["LRRC37A9P",0.309192898,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000271013","F7INR8,Uncharacterized protein","-","PF15779,Leucine-rich repeat-containing protein 37 family","IPR015753,Leucine-rich repeat-containing protein 37;IPR032754,Leucine-rich repeat-containing protein 37, N-terminal","ENOG410JC3Y,-;ENOG41118F7,-","-","-"]
["RP11-159D12.8",0.286195079,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000279207","A0A1X6RHA3,Integrase core domain","-","-","IPR036397,Ribonuclease H superfamily;IPR001584,Integrase, catalytic core;IPR012337,Ribonuclease H-like superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0015074,biological_process,DNA integration","-"]
["RP11-334C17.5",0.324525774,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000262580","G3RWD9,Caspase recruitment domain family member 14","XP_018883010.1,caspase recruitment domain-containing protein 14 isoform X1","PF00619,Caspase recruitment domain","IPR036034,PDZ superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001478,PDZ domain;IPR011029,Death-like domain superfamily;IPR008144,Guanylate kinase-like domain;IPR008145,Guanylate kinase/L-type calcium channel beta subunit;IPR001315,CARD domain","-","GO:0042981,biological_process,regulation of apoptotic process","-"]
["CTD-2538C1.2",2.926445452,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["CTC-453G23.8",2.936786249,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["CTC-444N24.8",1.200159579,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["D2HGDH",0.314874222,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000180902","K6Z916,D-2-hydroxyglutarate dehydrogenase","XP_016806433.1,D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X5","PF02913,AD linked oxidases, C-terminal domain;PF01565,AD binding domain","IPR016167,FAD-binding, type 2, subdomain 1;IPR016171,Vanillyl-alcohol oxidase, C-terminal subdomain 2;IPR006094,FAD linked oxidase, N-terminal;IPR016166,FAD-binding, type 2;IPR036318,FAD-binding, type 2-like superfamily;IPR016164,FAD-linked oxidase-like, C-terminal;IPR004113,FAD-linked oxidase, C-terminal","COG0277,FAD/FMN-containing dehydrogenases;KOG1232,Proteins containing the FAD binding domain","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0003824,molecular_function,catalytic activity;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0016614,molecular_function,oxidoreductase activity, acting on CH-OH group of donors","-"]
["RP5-1184F4.5",1.685822532,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000236772","Q4TEC3,Chromosome undetermined SCAF5507, whole genome shotgun sequence","-","-","-","-","-","-"]
["FAM86HP",1.277648745,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000253540","K7CSY4,Family with sequence similarity 86, member A","-","PF10294,Lysine methyltransferase;PF14904,amily of unknown function","IPR029426,FAM86;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR019410,Lysine methyltransferase","-","-","-"]
["WDFY3-AS1",3.371645065,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000251260","L9L5H5,WD repeat and FYVE domain-containing protein 3","-","PF01363,YVE zinc finger;PF00400,WD domain, G-beta repeat;PF15787,omain of unknown function (DUF4704);PF02138,Beige/BEACH domain","IPR017455,Zinc finger, FYVE-related;IPR019775,WD40 repeat, conserved site;IPR011011,Zinc finger, FYVE/PHD-type;IPR017986,WD40-repeat-containing domain;IPR036372,BEACH domain superfamily;IPR000306,FYVE zinc finger;IPR000409,BEACH domain;IPR036322,WD40-repeat-containing domain superfamily;IPR031570,Domain of unknown function DUF4704;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR023362,PH-BEACH domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR016024,Armadillo-type fold;IPR001680,WD40 repeat","-","GO:0046872,molecular_function,metal ion binding","-"]
["AF146191.4",0.721450094,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["DNAH5",0.100893537,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000039139","G3RU88,Dynein axonemal heavy chain 5","-","PF12774,Hydrolytic ATP binding site of dynein motor region D1;PF12777,Microtubule-binding stalk of dynein motor;PF07728,AAA domain (dynein-related subfamily);PF03028,ynein heavy chain and region D6 of dynein motor;PF12780,P-loop containing dynein motor region D4;PF08393,ynein heavy chain, N-terminal region 2;PF08385,ynein heavy chain, N-terminal region 1;PF12781,ATP-binding dynein motor region D5;PF12775,P-loop containing dynein motor region D3","-","-","-","-"]
["RP11-1277A3.2",0.982981086,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000246596","H2PHF8,SUMO interacting motifs containing 1","-","-","-","ENOG410IH7J,-;ENOG410XQXC,-","-","-"]
["FILIP1",0.186640581,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000118407","A8K2G7,cDNA FLJ76071, highly similar to Homo sapiens filamin A interacting protein 1","-","PF09727,Cortactin-binding protein-2","IPR019131,Cortactin-binding protein-2, N-terminal","ENOG410ZUI9,-;ENOG410IFP9,-","-","-"]
["THBS2",0.259843836,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000186340","K7CHV9,Thrombospondin 2","-","PF05735,Thrombospondin C-terminal region;PF00090,Thrombospondin type 1 domain;PF00093,von Willebrand factor type C domain;PF12947,domain;PF07645,Calcium-binding EGF domain;PF02412,Thrombospondin type 3 repeat","IPR024731,EGF domain;IPR008859,Thrombospondin, C-terminal;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR001007,VWFC domain;IPR003367,Thrombospondin, type 3-like repeat;IPR001791,Laminin G domain;IPR017897,Thrombospondin, type 3 repeat;IPR001881,EGF-like calcium-binding domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR028974,TSP type-3 repeat;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR015455,Thrombospondin-2;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily;IPR037349,Thrombospondin","-","GO:0016525,biological_process,negative regulation of angiogenesis;GO:0007155,biological_process,cell adhesion;GO:0031012,cellular_component,extracellular matrix;GO:0005509,molecular_function,calcium ion binding;GO:0030198,biological_process,extracellular matrix organization;GO:0008201,molecular_function,heparin binding;GO:0005576,cellular_component,extracellular region","-"]
["RP4-584D14.5",2.88079899,0,5.623276026,0.572269715,0.03361661,0.055389793,"-","-","-","-","-","-","-","-"]
["C8orf48",1.150325963,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000164743","G3RHY8,Chromosome 8 open reading frame 48","XP_004046732.1,uncharacterized protein C8orf48 homolog","PF15379,omain of unknown function (DUF4606)","IPR027932,Protein of unknown function DUF4606","-","-","-"]
["DNAJB5",0.282162794,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000137094","A0A096P196,DnaJ heat shock protein family","XP_003911602.1,-","PF01556,naJ C terminal domain;PF00226,naJ domain","IPR002939,Chaperone DnaJ, C-terminal;IPR036869,Chaperone J-domain superfamily;IPR018253,DnaJ domain, conserved site;IPR008971,HSP40/DnaJ peptide-binding;IPR001623,DnaJ domain","-","GO:0051087,molecular_function,chaperone binding;GO:0006457,biological_process,protein folding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006986,biological_process,response to unfolded protein;GO:0051082,molecular_function,unfolded protein binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["ZNF91",1.096286138,0.031515191,4.980674418,2.768531189,{"v":2.84e-09,"d":"2.84E-09"},{"v":2.35e-08,"d":"2.35E-08"},"ENSG00000167232","H2RD58,Zinc finger protein 91","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["POMZP3",4.848729458,0.176068482,4.644782027,2.47913501,{"v":2.71e-07,"d":"2.71E-07"},{"v":1.44E-6,"d":"1.44E-06"},"ENSG00000146707","A0A0J9YWR1,POM121 and ZP3 fusion protein","-","PF00100,Zona pellucida-like domain","IPR001507,Zona pellucida domain","-","-","-"]
["ALG1L",9.858962141,0.388687361,4.526607365,2.379029654,{"v":7.6e-07,"d":"7.60E-07"},{"v":3.68e-06,"d":"3.68E-06"},"ENSG00000189366","A0A087WZJ8,Putative glycosyltransferase ALG1-like","NP_001182152.1,putative glycosyltransferase ALG1-like isoform 1","-","IPR026051,Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like","KOG2941,Beta-1,4-mannosyltransferase;COG0438,Glycosyltransferase","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups","-"]
["ZNF100",1.149232403,0.049555875,4.397882077,2.27109308,{"v":3.62e-06,"d":"3.62E-06"},{"v":1.52E-5,"d":"1.52E-05"},"ENSG00000197020","A0A075B7G6,Zinc finger protein 100","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["GIN1",1.817007329,0.078350896,4.397882077,2.27109308,{"v":3.62e-06,"d":"3.62E-06"},{"v":1.52E-5,"d":"1.52E-05"},"ENSG00000145723","G3SDM7,Gypsy retrotransposon integrase 1","XP_004042371.1,gypsy retrotransposon integrase-like protein 1 isoform X1","-","IPR036397,Ribonuclease H superfamily;IPR001584,Integrase, catalytic core;IPR012337,Ribonuclease H-like superfamily","-","GO:0015074,biological_process,DNA integration;GO:0003676,molecular_function,nucleic acid binding","-"]
["LDHAP5",11.83483039,0.526790105,4.35228823,2.233151752,{"v":6.1E-6,"d":"6.10E-06"},{"v":2.44E-5,"d":"2.44E-05"},"ENSG00000213574","G7PQL6,L-lactate dehydrogenase","-","PF00056,lactate/malate dehydrogenase, NAD binding domain;PF02866,lactate/malate dehydrogenase, alpha/beta C-terminal domain","IPR022383,Lactate/malate dehydrogenase, C-terminal;IPR036291,NAD(P)-binding domain superfamily;IPR018177,L-lactate dehydrogenase, active site;IPR011304,L-lactate dehydrogenase;IPR001236,Lactate/malate dehydrogenase, N-terminal;IPR015955,Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal;IPR001557,L-lactate/malate dehydrogenase","-","GO:0005975,biological_process,carbohydrate metabolic process;GO:0005737,cellular_component,cytoplasm;GO:0016616,molecular_function,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0003824,molecular_function,catalytic activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0055114,biological_process,oxidation-reduction process;GO:0004459,molecular_function,L-lactate dehydrogenase activity;GO:0019752,biological_process,carboxylic acid metabolic process","-"]
["ADAD2",1.790626248,0.079704073,4.35228823,2.233151752,{"v":6.1E-6,"d":"6.10E-06"},{"v":2.44E-5,"d":"2.44E-05"},"ENSG00000140955","H2QBM2,Uncharacterized protein","XP_016785776.1,adenosine deaminase domain-containing protein 2 isoform X11","PF00035,ouble-stranded RNA binding motif;PF02137,Adenosine-deaminase (editase) domain","IPR002466,Adenosine deaminase/editase;IPR014720,Double-stranded RNA-binding domain","KOG2777,tRNA-specific adenosine deaminase 1;ENOG410XT0Z,-","GO:0003723,molecular_function,RNA binding;GO:0004000,molecular_function,adenosine deaminase activity;GO:0006396,biological_process,RNA processing","-"]
["DNAJC27",1.266679296,0.058261637,4.305206313,2.194136391,{"v":1.03E-5,"d":"1.03E-05"},{"v":3.92e-05,"d":"3.92E-05"},"ENSG00000115137","H2QHJ6,Uncharacterized protein","XP_001147370.1,-","PF00071,Ras family;PF00226,naJ domain","IPR036869,Chaperone J-domain superfamily;IPR001623,DnaJ domain;IPR005225,Small GTP-binding protein domain;IPR001806,Small GTPase superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1100,GTPase SAR1 and related small G proteins;KOG0098,GTPase Rab2, small G protein superfamily","GO:0005525,molecular_function,GTP binding;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0071701,biological_process,regulation of MAPK export from nucleus;GO:0003924,molecular_function,GTPase activity;GO:0005634,cellular_component,nucleus;GO:0043410,biological_process,positive regulation of MAPK cascade;GO:0005739,cellular_component,mitochondrion","-"]
["RSPH10B",1.426758333,0.065624563,4.305206313,2.194136391,{"v":1.03E-5,"d":"1.03E-05"},{"v":3.92e-05,"d":"3.92E-05"},"ENSG00000155026","H2QU64,Uncharacterized protein","XP_003318355.1,radial spoke head 10 homolog B isoform X2","PF02493,MORN repeat","IPR003409,MORN motif","KOG0231,Junctional membrane complex protein Junctophilin and related MORN repeat proteins;COG4642,Uncharacterized protein conserved in bacteria","-","-"]
["GATA4",1.549931176,0.073748243,4.256535907,2.153984001,{"v":1.74e-05,"d":"1.74E-05"},{"v":6.3E-5,"d":"6.30E-05"},"ENSG00000136574","H2PPJ2,GATA binding protein 4","XP_003777251.1,transcription factor GATA-4 isoform X2","PF00320,ATA zinc finger;PF05349,ATA-type transcription activator, N-terminal","IPR008013,GATA-type transcription activator, N-terminal;IPR016375,Transcription factor GATA-4/5/6;IPR000679,Zinc finger, GATA-type;IPR013088,Zinc finger, NHR/GATA-type","COG5641,GATA Zn-finger-containing transcription factor;KOG1601,GATA-4/5/6 transcription factors","GO:0003197,biological_process,endocardial cushion development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0005634,cellular_component,nucleus;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0008584,biological_process,male gonad development;GO:0003290,biological_process,atrial septum secundum morphogenesis;GO:0042493,biological_process,response to drug;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0001076,molecular_function,transcription factor activity, RNA polymerase II transcription factor binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0060413,biological_process,atrial septum morphogenesis;GO:0090575,cellular_component,RNA polymerase II transcription factor complex;GO:0016604,cellular_component,nuclear body;GO:0008270,molecular_function,zinc ion binding;GO:0003713,molecular_function,transcription coactivator activity;GO:0046872,molecular_function,metal ion binding;GO:0070410,molecular_function,co-SMAD binding;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0060575,biological_process,intestinal epithelial cell differentiation","-"]
["ZYG11A",1.416464437,0.069804739,4.206166069,2.112625894,{"v":1.74e-05,"d":"1.74E-05"},{"v":6.3E-5,"d":"6.30E-05"},"ENSG00000203995","H2R931,Uncharacterized protein","-","-","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","ENOG410XPSX,-;KOG3665,ZYG-1-like serine/threonine protein kinases","GO:0016567,biological_process,protein ubiquitination;GO:0051438,biological_process,regulation of ubiquitin-protein transferase activity;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0031462,cellular_component,Cul2-RING ubiquitin ligase complex","-"]
["RP11-486L19.2",2.316684344,0.114168448,4.206166069,2.112625894,{"v":1.74e-05,"d":"1.74E-05"},{"v":6.3E-5,"d":"6.30E-05"},"ENSG00000250685","Q6ZW55,cDNA FLJ41588 fis, clone CTONG2020806","-","-","-","-","-","-"]
["RP5-1112D6.8",1.485845637,0.075935908,4.153973815,2.06998698,{"v":2.95e-05,"d":"2.95E-05"},1.00331E-4,"ENSG00000272356","H2PK26,Uncharacterized protein","-","-","-","-","-","-"]
["C9orf72",0.979297861,0.054052036,4.043558682,1.98052932,{"v":8.47e-05,"d":"8.47E-05"},0.000260038,"ENSG00000147894","A0A1U7SX69,protein C9orf72 homolog","XP_008046151.1,-","-","IPR027819,Guanine nucleotide exchange C9orf72","-","GO:0044304,cellular_component,main axon;GO:2000785,biological_process,regulation of autophagosome assembly;GO:0005634,cellular_component,nucleus;GO:0005615,cellular_component,extracellular space;GO:0010506,biological_process,regulation of autophagy;GO:0017137,molecular_function,Rab GTPase binding;GO:0005737,cellular_component,cytoplasm;GO:0016239,biological_process,positive regulation of macroautophagy;GO:0065009,biological_process,regulation of molecular function;GO:0005776,cellular_component,autophagosome;GO:0000932,cellular_component,P-body;GO:0032045,cellular_component,guanyl-nucleotide exchange factor complex;GO:0110053,biological_process,regulation of actin filament organization;GO:0044295,cellular_component,axonal growth cone;GO:0010494,cellular_component,cytoplasmic stress granule;GO:1990316,cellular_component,Atg1/ULK1 kinase complex;GO:0005768,cellular_component,endosome;GO:0034063,biological_process,stress granule assembly;GO:0017112,molecular_function,Rab guanyl-nucleotide exchange factor activity;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0006914,biological_process,autophagy;GO:0005764,cellular_component,lysosome;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0048675,biological_process,axon extension;GO:1903432,biological_process,regulation of TORC1 signaling;GO:0006897,biological_process,endocytosis","-"]
["USP30-AS1",8.325584362,0.499486959,3.923987453,1.884847603,2.43751E-4,0.000677843,"-","-","-","-","-","-","-","-"]
["CACTIN-AS1",2.854983451,0.171282512,3.923987453,1.884847603,2.43751E-4,0.000677843,"ENSG00000226800","H2QEZ2,Uncharacterized protein","-","-","-","-","-","-"]
["SATB2",0.498410599,0.029901756,3.923987453,1.884847603,2.43751E-4,0.000677843,"ENSG00000119042","H2QJ76,DNA-binding protein SATB","-","PF02376,CUT domain;PF16534,Ubiquitin-like oligomerisation domain of SATB;PF16557,CUT1-like DNA-binding domain of SATB;PF00046,Homeobox domain","IPR032392,SATB, ubiquitin-like oligomerisation domain;IPR009057,Homeobox-like domain superfamily;IPR010982,Lambda repressor-like, DNA-binding domain superfamily;IPR038216,SATB, CUTL domain superfamily;IPR032355,SATB, CUT1-like DNA-binding domain;IPR003350,CUT domain;IPR001356,Homeobox domain;IPR038224,SATB, ULD domain superfamily","ENOG410ISJ9,-;ENOG41113K2,-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["POU6F2",0.663538251,0.039808461,3.923987453,1.884847603,2.43751E-4,0.000677843,"ENSG00000106536","A0A140GPP8,POU domain protein","-","PF00157,Pou domain - N-terminal to homeobox domain;PF00046,Homeobox domain","IPR009057,Homeobox-like domain superfamily;IPR010982,Lambda repressor-like, DNA-binding domain superfamily;IPR033056,POU domain, class 6, transcription factor 2;IPR013847,POU domain;IPR001356,Homeobox domain;IPR000327,POU-specific domain","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0005634,cellular_component,nucleus;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0006351,biological_process,transcription, DNA-templated;GO:0007275,biological_process,multicellular organism development","-"]
["ZNF223",1.569277019,0.098426989,3.860267753,1.834388636,4.1343E-4,0.001091247,"ENSG00000178386","K7ENM7,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TAMM41",0.881708556,0.055301847,3.860267753,1.834388636,4.1343E-4,0.001091247,"ENSG00000144559","A0A1D5Q3J2,TAM41 mitochondrial translocator assembly and maintenance homolog","-","-","IPR015222,Phosphatidate cytidylyltransferase, mitochondrial","-","GO:0004605,molecular_function,phosphatidate cytidylyltransferase activity;GO:0032049,biological_process,cardiolipin biosynthetic process","-"]
["RP13-131K19.6",13.36092889,0.838013926,3.860267753,1.834388636,4.1343E-4,0.001091247,"ENSG00000272434","L8Y3Y1,Inosine-5'-monophosphate dehydrogenase","-","PF00478,IMP dehydrogenase / GMP reductase domain;PF00571,CBS domain","IPR001093,IMP dehydrogenase/GMP reductase;IPR000644,CBS domain;IPR015875,IMP dehydrogenase / GMP reductase, conserved site;IPR005990,Inosine-5'-monophosphate dehydrogenase;IPR013785,Aldolase-type TIM barrel","-","GO:0006164,biological_process,purine nucleotide biosynthetic process;GO:0005737,cellular_component,cytoplasm;GO:0003824,molecular_function,catalytic activity;GO:0046872,molecular_function,metal ion binding;GO:0005634,cellular_component,nucleus;GO:0016491,molecular_function,oxidoreductase activity;GO:0055114,biological_process,oxidation-reduction process;GO:0003938,molecular_function,IMP dehydrogenase activity;GO:0000166,molecular_function,nucleotide binding;GO:0006177,biological_process,GMP biosynthetic process","-"]
["GXYLT2",1.42463136,0.089354635,3.860267753,1.834388636,4.1343E-4,0.001091247,"ENSG00000172986","G3QQT0,Glucoside xylosyltransferase 2","-","PF01501,lycosyl transferase family 8","IPR029044,Nucleotide-diphospho-sugar transferases;IPR002495,Glycosyl transferase, family 8","-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity","-"]
["IGSF11",1.066365217,0.066883741,3.860267753,1.834388636,4.1343E-4,0.001091247,"ENSG00000144847","G3SKJ6,Immunoglobulin superfamily member 11","XP_018880342.1,-","PF13927,Immunoglobulin domain;PF07686,Immunoglobulin V-set domain","IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["KLF9",1.009492405,0.063316608,3.860267753,1.834388636,4.1343E-4,0.001091247,"ENSG00000119138","H2PSC7,Kruppel like factor 9","XP_002819900.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0097067,biological_process,cellular response to thyroid hormone stimulus;GO:0071387,biological_process,cellular response to cortisol stimulus;GO:0003676,molecular_function,nucleic acid binding;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0010839,biological_process,negative regulation of keratinocyte proliferation;GO:0005634,cellular_component,nucleus;GO:0007623,biological_process,circadian rhythm;GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-706O15.3",1.192449942,0.07479193,3.860267753,1.834388636,4.1343E-4,0.001091247,"ENSG00000234449","H2QW07,Uncharacterized protein","-","-","-","-","-","-"]
["NIF3L1",9.4505549,0.660278983,3.804497047,3.466852567,{"v":1.57e-11,"d":"1.57E-11"},2.17E-10,"ENSG00000196290","A0A024R3V7,NIF3-like protein 1","XP_016860119.1,-;XP_005246799.1,-;NP_001129511.1,NIF3-like protein 1 isoform 1;XP_011509884.1,-;XP_011509885.1,-;XP_011509886.1,-","PF01784,NIF3 (NGG1p interacting factor 3)","IPR002678,GTP cyclohydrolase 1 type 2/Nif3;IPR017222,NIF3-like protein 1, animal;IPR036069,GTP cyclohydrolase 1 type 2/Nif3 superfamily","KOG4131,Ngg1-interacting factor 3 protein NIF3L1;COG0327,Uncharacterized conserved protein","GO:0005737,cellular_component,cytoplasm;GO:0005634,cellular_component,nucleus;GO:0005739,cellular_component,mitochondrion;GO:0030182,biological_process,neuron differentiation;GO:1903507,biological_process,negative regulation of nucleic acid-templated transcription","-"]
["RP11-172H24.4",1.130250012,0.07426642,3.793603169,1.782006921,0.000700954,0.001751352,"ENSG00000278291","H2PAT5,Uncharacterized protein","-","-","-","ENOG410J5KQ,-;ENOG410XV2W,-","-","-"]
["RP11-332M2.1",5.479849507,0.36006972,3.793603169,1.782006921,0.000700954,0.001751352,"ENSG00000203644","Q6ZPD3,cDNA FLJ26015 fis, clone MPC03596","-","-","-","-","-","-"]
["RP11-804A23.4",28.53390748,2.002016976,3.787038286,3.081262672,{"v":4.53e-09,"d":"4.53E-09"},{"v":3.6e-08,"d":"3.60E-08"},"-","-","-","-","-","-","-","-"]
["DDIAS",1.734584317,0.122743377,3.752371988,2.547554994,{"v":8.97e-07,"d":"8.97E-07"},{"v":4.27e-06,"d":"4.27E-06"},"ENSG00000165490","A8K8N4,cDNA FLJ78751","-","PF08646,Replication factor-A C terminal domain","IPR013955,Replication factor A, C-terminal;IPR012340,Nucleic acid-binding, OB-fold","ENOG41122YI,-;ENOG410IGF0,-","-","-"]
["ZNF41",3.772360168,0.273966091,3.748748108,3.418379801,{"v":5.33e-11,"d":"5.33E-11"},{"v":6.47e-10,"d":"6.47E-10"},"ENSG00000147124","A0A024R1C4,Zinc finger protein 41, isoform CRA_d","NP_001311076.1,-;NP_001311073.1,-;XP_016885306.1,-;NP_001311079.1,-;NP_001311069.1,-;NP_009061.1,-;NP_700359.1,zinc finger protein 41 isoform a","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["PLCB4",0.688290276,0.047487456,3.723708252,1.727549752,0.000700954,0.001751352,"ENSG00000101333","G1RW33,Phosphoinositide phospholipase C","XP_012365925.1,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1","PF06631,Protein of unknown function (DUF1154);PF09279,Phosphoinositide-specific phospholipase C, efhand-like;PF00387,Phosphatidylinositol-specific phospholipase C, Y domain;PF00168,C2 domain;PF00388,Phosphatidylinositol-specific phospholipase C, X domain","IPR000909,Phosphatidylinositol-specific phospholipase C, X domain;IPR001192,Phosphoinositide phospholipase C family;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily;IPR037862,PLC-beta, PH domain;IPR016280,Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR009535,Phospholipase C-beta, conserved site;IPR011992,EF-hand domain pair;IPR001711,Phospholipase C, phosphatidylinositol-specific, Y domain;IPR015359,Phosphoinositide-specific phospholipase C, EF-hand-like domain","KOG0169,Phosphoinositide-specific phospholipase C;ENOG410XPSW,-","GO:0006629,biological_process,lipid metabolic process;GO:0004435,molecular_function,phosphatidylinositol phospholipase C activity;GO:0016787,molecular_function,hydrolase activity;GO:0030425,cellular_component,dendrite;GO:0005790,cellular_component,smooth endoplasmic reticulum;GO:0035556,biological_process,intracellular signal transduction;GO:0004871,molecular_function,signal transducer activity;GO:0005509,molecular_function,calcium ion binding;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0014069,cellular_component,postsynaptic density;GO:0016042,biological_process,lipid catabolic process;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction","-"]
["PWP2",0.686102702,0.047336528,3.723708252,1.727549752,0.000700954,0.001751352,"ENSG00000241945","A0A0B4J2E5,Uncharacterized protein","XP_006723973.1,periodic tryptophan protein 2 homolog;XP_011507205.1,-","PF00400,WD domain, G-beta repeat;PF04003,ip2/Utp12 Family","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR007148,Small-subunit processome, Utp12;IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR027145,Periodic tryptophan protein 2;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat","ENOG410XP2P,-;KOG0291,WD40-repeat-containing subunit of the 18S rRNA processing complex","GO:0032040,cellular_component,small-subunit processome;GO:0030515,molecular_function,snoRNA binding;GO:0000028,biological_process,ribosomal small subunit assembly;GO:0034388,cellular_component,Pwp2p-containing subcomplex of 90S preribosome;GO:0000462,biological_process,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","-"]
["RCL1",1.12673853,0.077737472,3.723708252,1.727549752,0.000700954,0.001751352,"ENSG00000120158","K7DRH4,RNA terminal phosphate cyclase-like 1","-","PF01137,RNA 3'-terminal phosphate cyclase;PF05189,RNA 3'-terminal phosphate cyclase (RTC), insert domain","IPR000228,RNA 3'-terminal phosphate cyclase;IPR016443,RNA 3'-terminal phosphate cyclase type 2;IPR013791,RNA 3'-terminal phosphate cyclase, insert domain;IPR036553,RNA 3'-terminal phosphate cyclase, insert domain superfamily;IPR023797,RNA 3'-terminal phosphate cyclase domain;IPR020719,RNA 3'-terminal phosphate cyclase-like, conserved site;IPR037136,RNA 3'-terminal phosphate cyclase domain superfamily;IPR013792,RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta","KOG3980,RNA 3'-terminal phosphate cyclase;COG0430,RNA 3'-terminal phosphate cyclase","GO:0042254,biological_process,ribosome biogenesis;GO:0003824,molecular_function,catalytic activity;GO:0006396,biological_process,RNA processing;GO:0005730,cellular_component,nucleolus","-"]
["ABHD17B",1.605002672,0.11073452,3.723708252,1.727549752,0.000700954,0.001751352,"ENSG00000107362","H2QXC4,Abhydrolase domain containing 17B","XP_009455002.2,-;XP_009455000.2,-;XP_016816444.1,-","PF12146,Serine aminopeptidase, S33;PF00326,Prolyl oligopeptidase family","IPR022742,Serine aminopeptidase, S33;IPR029058,Alpha/Beta hydrolase fold","COG1073,Hydrolases of the alpha/beta superfamily;KOG1552,Predicted alpha/beta hydrolase","GO:1905668,biological_process,positive regulation of protein localization to endosome;GO:0014069,cellular_component,postsynaptic density;GO:0055038,cellular_component,recycling endosome membrane;GO:0002084,biological_process,protein depalmitoylation;GO:0018345,biological_process,protein palmitoylation;GO:1902817,biological_process,negative regulation of protein localization to microtubule;GO:0008474,molecular_function,palmitoyl-(protein) hydrolase activity;GO:0005886,cellular_component,plasma membrane;GO:1902950,biological_process,regulation of dendritic spine maintenance;GO:1902473,biological_process,regulation of protein localization to synapse","-"]
["WDR19",0.990197833,0.073856293,3.676711876,2.484756229,{"v":2.4e-06,"d":"2.40E-06"},{"v":1.05e-05,"d":"1.05E-05"},"ENSG00000157796","H2QPC5,WD repeat domain 19","XP_517152.2,WD repeat-containing protein 19 isoform X2","PF15911,WD domain, G-beta repeat","IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain;IPR011990,Tetratricopeptide-like helical domain superfamily","KOG2247,WD40 repeat-containing protein;ENOG410XR20,-","GO:0097730,cellular_component,non-motile cilium;GO:0007224,biological_process,smoothened signaling pathway;GO:0032391,cellular_component,photoreceptor connecting cilium;GO:0060830,biological_process,ciliary receptor clustering involved in smoothened signaling pathway;GO:0000902,biological_process,cell morphogenesis;GO:0060271,biological_process,cilium assembly;GO:0060831,biological_process,smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0035721,biological_process,intraciliary retrograde transport;GO:0008406,biological_process,gonad development;GO:0030991,cellular_component,intraciliary transport particle A;GO:0055123,biological_process,digestive system development;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0031076,biological_process,embryonic camera-type eye development;GO:0016604,cellular_component,nuclear body;GO:0042471,biological_process,ear morphogenesis;GO:0061055,biological_process,myotome development;GO:0050877,biological_process,nervous system process;GO:0005929,cellular_component,cilium;GO:0048701,biological_process,embryonic cranial skeleton morphogenesis;GO:0031514,cellular_component,motile cilium;GO:0001701,biological_process,in utero embryonic development;GO:0005654,cellular_component,nucleoplasm","-"]
["FZD4",2.862515635,0.221903999,3.661627373,3.634979262,{"v":1.97e-12,"d":"1.97E-12"},{"v":3.31e-11,"d":"3.31E-11"},"ENSG00000174804","A0A096MVT8,Frizzled class receptor 4","XP_003910563.1,-","PF01392,z domain;PF01534,rizzled/Smoothened family membrane region","IPR015526,Frizzled/secreted frizzled-related protein;IPR017981,GPCR, family 2-like;IPR036790,Frizzled cysteine-rich domain superfamily;IPR000539,Frizzled/Smoothened, transmembrane domain;IPR026551,Frizzled-4;IPR020067,Frizzled domain","-","GO:0061299,biological_process,retina vasculature morphogenesis in camera-type eye;GO:0001570,biological_process,vasculogenesis;GO:0030947,biological_process,regulation of vascular endothelial growth factor receptor signaling pathway;GO:0016055,biological_process,Wnt signaling pathway;GO:0019955,molecular_function,cytokine binding;GO:0005886,cellular_component,plasma membrane;GO:0046982,molecular_function,protein heterodimerization activity;GO:0017147,molecular_function,Wnt-protein binding;GO:0009986,cellular_component,cell surface;GO:0010812,biological_process,negative regulation of cell-substrate adhesion;GO:0016020,cellular_component,membrane;GO:0042701,biological_process,progesterone secretion;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0007605,biological_process,sensory perception of sound;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0035426,biological_process,extracellular matrix-cell signaling;GO:0061301,biological_process,cerebellum vasculature morphogenesis;GO:0001553,biological_process,luteinization;GO:0038023,molecular_function,signaling receptor activity;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0031987,biological_process,locomotion involved in locomotory behavior;GO:0016021,cellular_component,integral component of membrane;GO:0106003,cellular_component,amyloid-beta complex;GO:0030425,cellular_component,dendrite;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0051091,biological_process,positive regulation of DNA binding transcription factor activity;GO:0001540,molecular_function,amyloid-beta binding;GO:0043507,biological_process,positive regulation of JUN kinase activity;GO:0034446,biological_process,substrate adhesion-dependent cell spreading;GO:0005911,cellular_component,cell-cell junction;GO:0042813,molecular_function,Wnt-activated receptor activity;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0030165,molecular_function,PDZ domain binding;GO:0007223,biological_process,Wnt signaling pathway, calcium modulating pathway;GO:0150012,biological_process,positive regulation of neuron projection arborization;GO:0001568,biological_process,blood vessel development;GO:0061304,biological_process,retinal blood vessel morphogenesis;GO:0007275,biological_process,multicellular organism development","-"]
["SAP130",25.63027408,2.023076382,3.65806705,5.947337781,1.41E-31,{"v":4.13e-29,"d":"4.13E-29"},"ENSG00000136715","K7C519,Sin3A-associated protein, 130kDa","XP_525910.3,-","PF16014,Histone deacetylase complex subunit SAP130 C-terminus","IPR024137,Histone deacetylase complex subunit SAP130;IPR031963,Histone deacetylase complex subunit SAP130, C-terminal domain","ENOG410ZRAM,-;ENOG410IJKN,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0016607,cellular_component,nuclear speck;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II","-"]
["LYPD5",0.88621936,0.064361313,3.650253927,1.670845564,0.001187534,0.002821641,"ENSG00000159871","B4DWV3,cDNA FLJ54820, highly similar to Ly6/PLAUR domain-containing protein 5","-","PF00021,u-PAR/Ly-6 domain","IPR018363,CD59 antigen, conserved site;IPR016054,Ly-6 antigen/uPA receptor-like","ENOG410IX2N,-;ENOG4111DV8,-","-","-"]
["ZNF234",0.865977497,0.062891256,3.650253927,1.670845564,0.001187534,0.002821641,"ENSG00000263002","A0A024R0N3,Zinc finger protein 234, isoform CRA_a","NP_006621.1,zinc finger protein 234;NP_001138296.1,-;XP_016881638.1,-;XP_006723037.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["AC074212.6",4.393128296,0.319049119,3.650253927,1.670845564,0.001187534,0.002821641,"ENSG00000267395","U6D1S4,Dystrophia myotonica-protein kinase","-","PF08826,MPK coiled coil domain like","IPR014930,Myotonic dystrophy protein kinase, coiled coil","-","GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0016310,biological_process,phosphorylation","-"]
["RP3-337O18.9",7.929249139,0.575858427,3.650253927,1.670845564,0.001187534,0.002821641,"ENSG00000271984","U3KQU6,Carboxypeptidase","-","PF00450,Serine carboxypeptidase","IPR018202,Serine carboxypeptidase, serine active site;IPR001563,Peptidase S10, serine carboxypeptidase;IPR029058,Alpha/Beta hydrolase fold","KOG1282,Serine carboxypeptidases (lysosomal cathepsin A);COG2939,Carboxypeptidase C (cathepsin A)","GO:0006508,biological_process,proteolysis;GO:0004180,molecular_function,carboxypeptidase activity;GO:0016787,molecular_function,hydrolase activity;GO:0008233,molecular_function,peptidase activity;GO:0004185,molecular_function,serine-type carboxypeptidase activity","-"]
["NKD2",1.563862309,0.113574851,3.650253927,1.670845564,0.001187534,0.002821641,"ENSG00000145506","G3QPA3,Naked cuticle homolog 2","-","-","IPR002048,EF-hand domain;IPR011992,EF-hand domain pair","-","GO:0005509,molecular_function,calcium ion binding","-"]
["PLBD2",34.40011991,2.740910947,3.646520385,6.628621359,{"v":2.09e-37,"d":"2.09E-37"},{"v":7.48e-35,"d":"7.48E-35"},"ENSG00000151176","K7B3B5,Phospholipase B-like","XP_016779803.1,putative phospholipase B-like 2","PF04916,Phospholipase B","IPR007000,Phospholipase B-like","ENOG410XQRV,-;KOG3774,Uncharacterized conserved protein Lama","GO:0006629,biological_process,lipid metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0016042,biological_process,lipid catabolic process","-"]
["PMP22",2.922586403,0.224043381,3.637339889,2.452251326,{"v":2.4e-06,"d":"2.40E-06"},{"v":1.05e-05,"d":"1.05E-05"},"ENSG00000109099","J3KT36,Peripheral myelin protein 22","-","-","-","-","-","-"]
["ALDH3B2",5.06483772,0.405148,3.609623641,3.29827162,{"v":6.37e-10,"d":"6.37E-10"},{"v":6.15e-09,"d":"6.15E-09"},"ENSG00000132746","H2R571,Uncharacterized protein","-","PF00171,Aldehyde dehydrogenase family","IPR016163,Aldehyde dehydrogenase, C-terminal;IPR016160,Aldehyde dehydrogenase, cysteine active site;IPR015590,Aldehyde dehydrogenase domain;IPR016162,Aldehyde dehydrogenase, N-terminal;IPR016161,Aldehyde/histidinol dehydrogenase;IPR029510,Aldehyde dehydrogenase, glutamic acid active site","COG1012,NAD-dependent aldehyde dehydrogenases;KOG2456,Aldehyde dehydrogenase","GO:0016620,molecular_function,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0008152,biological_process,metabolic process","-"]
["ZSCAN30",1.541563989,0.122720391,3.605310843,2.926550942,{"v":6.37e-08,"d":"6.37E-08"},{"v":3.91e-07,"d":"3.91E-07"},"ENSG00000186814","H2R2W3,Zinc finger and SCAN domain containing 30","XP_529948.2,zinc finger and SCAN domain-containing protein 30 isoform X1;XP_016789019.1,-;XP_009432158.1,-","PF00096,Zinc finger, C2H2 type;PF02023,SCAN domain","IPR003309,SCAN domain;IPR013087,Zinc finger C2H2-type;IPR038269,SCAN domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["AC004510.3",190.2520745,15.6729899,3.597221709,6.131912623,1.18E-32,{"v":3.81e-30,"d":"3.81E-30"},"-","-","-","-","-","-","-","-"]
["LINC00857",3.828238178,0.301854855,3.596863199,2.418961629,{"v":3.93e-06,"d":"3.93E-06"},{"v":1.64e-05,"d":"1.64E-05"},"-","-","-","-","-","-","-","-"]
["PTGDR2",2.870848043,0.226365074,3.596863199,2.418961629,{"v":3.93e-06,"d":"3.93E-06"},{"v":1.64e-05,"d":"1.64E-05"},"ENSG00000183134","A8K5Q6,cDNA FLJ75694, highly similar to Homo sapiens G protein-coupled receptor 44","-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR017452,GPCR, rhodopsin-like, 7TM;IPR000276,G protein-coupled receptor, rhodopsin-like","ENOG410YAX7,-;ENOG410IV6V,-","GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["RP11-245P10.8",8.904755448,0.682632177,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000270094","F7GJX2,Uncharacterized protein","-","PF15227,zinc finger of C3HC4-type, RING;PF00643,B-box zinc finger;PF13765,SPRY-associated domain;PF00622,SPRY domain","IPR001841,Zinc finger, RING-type;IPR000315,B-box-type zinc finger;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG4111G04,-;KOG2177,Predicted E3 ubiquitin ligase","GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TRDMT1",0.405722128,0.031102368,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000107614","Q6ICS7,DNMT2 protein","NP_004403.1,tRNA (cytosine(38)-C(5))-methyltransferase isoform a","PF00145,C-5 cytosine-specific DNA methylase","IPR001525,C-5 cytosine methyltransferase;IPR031303,DNA methylase, C-5 cytosine-specific,  conserved site;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase","KOG0919,C-5 cytosine-specific DNA methylase;COG0270,Site-specific DNA methylase","GO:0030488,biological_process,tRNA methylation;GO:0016740,molecular_function,transferase activity;GO:0001975,biological_process,response to amphetamine;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0008175,molecular_function,tRNA methyltransferase activity","-"]
["HNRNPLP2",2.722473003,0.208702831,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000259917","G3QN86,Heterogeneous nuclear ribonucleoprotein L","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF13893,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034816,hnRNP-L, RNA recognition motif 3;IPR034817,hnRNP-L, RNA recognition motif 4;IPR035005,hnRNP-L, RNA recognition motif 1;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR035008,hnRNP-L, RNA recognition motif 2;IPR006536,HnRNP-L/PTB","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0006397,biological_process,mRNA processing;GO:0005634,cellular_component,nucleus","-"]
["RP11-20B24.4",3.381552702,0.259227409,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000266642","H2QCJ6,Dehydrogenase/reductase 13","-","PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily","COG1028,Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases);KOG1208,Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)","-","-"]
["WNT3",0.986221185,0.07560301,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000108379","A0A096P676,Protein Wnt","XP_003913271.1,-","PF00110,wnt family","IPR018161,Wnt protein, conserved site;IPR005817,Wnt;IPR009141,Wnt-3 protein","-","GO:0044339,biological_process,canonical Wnt signaling pathway involved in osteoblast differentiation;GO:0005578,,;GO:0009948,biological_process,anterior/posterior axis specification;GO:0060174,biological_process,limb bud formation;GO:0016055,biological_process,Wnt signaling pathway;GO:0005102,molecular_function,signaling receptor binding;GO:0005109,molecular_function,frizzled binding;GO:0048697,biological_process,positive regulation of collateral sprouting in absence of injury;GO:0005576,cellular_component,extracellular region;GO:0000902,biological_process,cell morphogenesis;GO:0009950,biological_process,dorsal/ventral axis specification;GO:0050767,biological_process,regulation of neurogenesis;GO:0048843,biological_process,negative regulation of axon extension involved in axon guidance;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0001707,biological_process,mesoderm formation;GO:0030177,biological_process,positive regulation of Wnt signaling pathway;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0060173,biological_process,limb development;GO:0048646,biological_process,anatomical structure formation involved in morphogenesis;GO:0010628,biological_process,positive regulation of gene expression;GO:1905474,biological_process,canonical Wnt signaling pathway involved in stem cell proliferation;GO:0060064,biological_process,Spemann organizer formation at the anterior end of the primitive streak;GO:0007411,biological_process,axon guidance;GO:0007276,biological_process,gamete generation;GO:0035115,biological_process,embryonic forelimb morphogenesis;GO:0072089,biological_process,stem cell proliferation;GO:0061180,biological_process,mammary gland epithelium development;GO:0044338,biological_process,canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation;GO:1904954,biological_process,canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;GO:0048018,molecular_function,receptor ligand activity;GO:0019904,molecular_function,protein domain specific binding;GO:0035116,biological_process,embryonic hindlimb morphogenesis;GO:0060323,biological_process,head morphogenesis;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0007275,biological_process,multicellular organism development","-"]
["ZNF420",1.0624615,0.081447538,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000197050","G3QF75,Zinc finger protein 420","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","-","-","-","-"]
["CTC-490E21.12",7.433534983,0.56984947,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000268797","M0QY20,Uncharacterized protein","-","-","-","KOG3710,EGL-Nine (EGLN) protein;ENOG410ZHZN,-","-","-"]
["ZNF525",0.593238392,0.04547723,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000203326","J3KR51,HCG1787564","NP_001335085.1,zinc finger protein 525 isoform 1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["AC073641.2",9.963362739,0.763784254,3.572858125,1.611700709,0.002009464,0.004538709,"-","-","-","-","-","-","-","-"]
["NSUN3",0.758523978,0.058147905,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000178694","H2QMZ2,NOP2/Sun domain family, member 3","XP_516606.2,putative methyltransferase NSUN3 isoform X2","PF01189,16S rRNA methyltransferase RsmB/F","IPR001678,SAM-dependent methyltransferase RsmB/NOP2-type;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR023267,RNA (C5-cytosine) methyltransferase","COG0144,tRNA and rRNA cytosine-C5-methylases;KOG2198,tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily","GO:0031167,biological_process,rRNA methylation;GO:0016428,molecular_function,tRNA (cytosine-5-)-methyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0003723,molecular_function,RNA binding;GO:0032259,biological_process,methylation;GO:0005759,cellular_component,mitochondrial matrix;GO:0008168,molecular_function,methyltransferase activity;GO:0002127,biological_process,tRNA wobble base cytosine methylation;GO:0005762,cellular_component,mitochondrial large ribosomal subunit;GO:0070129,biological_process,regulation of mitochondrial translation;GO:0005739,cellular_component,mitochondrion","-"]
["PDE8B",0.615536091,0.047186556,3.572858125,1.611700709,0.002009464,0.004538709,"ENSG00000113231","H2PFX7,Phosphodiesterase","-","PF13426,PAS domain;PF00233,3'5'-cyclic nucleotide phosphodiesterase;PF08629,PDE8 phosphodiesterase","IPR000014,PAS domain;IPR023088,3'5'-cyclic nucleotide phosphodiesterase;IPR013938,3'5'-cyclic nucleotide phosphodiesterase PDE8;IPR035965,PAS domain superfamily;IPR002073,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain;IPR003607,HD/PDEase domain;IPR023174,3'5'-cyclic nucleotide phosphodiesterase, conserved site;IPR036971,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily","ENOG410XP9B,-;KOG1229,3'5'-cyclic nucleotide phosphodiesterases","GO:0007165,biological_process,signal transduction;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0004114,molecular_function,3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0016787,molecular_function,hydrolase activity;GO:0046872,molecular_function,metal ion binding","-"]
["PLCG1",0.836820578,0.0679236,3.55521802,2.384847951,{"v":6.44e-06,"d":"6.44E-06"},{"v":2.56e-05,"d":"2.56E-05"},"ENSG00000124181","G3QXU1,Phosphoinositide phospholipase C","XP_018872528.1,-;XP_018872526.1,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3","PF00018,SH3 domain;PF00387,Phosphatidylinositol-specific phospholipase C, Y domain;PF00017,SH2 domain;PF00168,C2 domain;PF00388,Phosphatidylinositol-specific phospholipase C, X domain","IPR018247,EF-Hand 1, calcium-binding site;IPR035024,PLC-gamma, N-terminal SH2 domain;IPR001711,Phospholipase C, phosphatidylinositol-specific, Y domain;IPR036860,SH2 domain superfamily;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily;IPR000909,Phosphatidylinositol-specific phospholipase C, X domain;IPR035892,C2 domain superfamily;IPR001192,Phosphoinositide phospholipase C family;IPR028380,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;IPR000980,SH2 domain;IPR002048,EF-hand domain;IPR016279,Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma;IPR036028,SH3-like domain superfamily;IPR001849,Pleckstrin homology domain;IPR001452,SH3 domain;IPR011992,EF-hand domain pair;IPR035724,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain;IPR011993,PH-like domain superfamily;IPR035023,PLC-gamma, C-terminal SH2 domain;IPR000008,C2 domain","-","GO:0006629,biological_process,lipid metabolic process;GO:0004435,molecular_function,phosphatidylinositol phospholipase C activity;GO:0016787,molecular_function,hydrolase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0004871,molecular_function,signal transducer activity;GO:0005509,molecular_function,calcium ion binding;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0009395,biological_process,phospholipid catabolic process;GO:0005622,cellular_component,intracellular;GO:0016042,biological_process,lipid catabolic process;GO:0007165,biological_process,signal transduction","-"]
["FBXL2",1.518208131,0.128260743,3.519826482,2.854571288,{"v":2.42e-07,"d":"2.42E-07"},{"v":1.3E-6,"d":"1.30E-06"},"ENSG00000153558","A0A0D9RAL7,F-box and leucine rich repeat protein 2","-","PF12937,-box-like;PF13516,Leucine Rich repeat","IPR001611,Leucine-rich repeat;IPR006553,Leucine-rich repeat, cysteine-containing subtype;IPR032675,Leucine-rich repeat domain superfamily;IPR001810,F-box domain","-","GO:0019005,cellular_component,SCF ubiquitin ligase complex;GO:0010506,biological_process,regulation of autophagy;GO:0036312,molecular_function,phosphatidylinositol 3-kinase regulatory subunit binding;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016567,biological_process,protein ubiquitination;GO:0019903,molecular_function,protein phosphatase binding;GO:0044830,biological_process,modulation by host of viral RNA genome replication;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0014066,biological_process,regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component,membrane;GO:0031146,biological_process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0006513,biological_process,protein monoubiquitination","-"]
["ZNF678",0.87898876,0.073508344,3.512334878,2.349868103,{"v":1.06E-5,"d":"1.06E-05"},{"v":4e-05,"d":"4.00E-05"},"ENSG00000181450","G7NTU9,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["JKAMP",1.801421792,0.15064986,3.512334878,2.349868103,{"v":1.06E-5,"d":"1.06E-05"},{"v":4e-05,"d":"4.00E-05"},"ENSG00000050130","G3V2M4,Chromosome 14 open reading frame 100, isoform CRA_b","NP_001271130.1,JNK1/MAPK8-associated membrane protein isoform 3","PF05571,Protein of unknown function (DUF766)","IPR008485,JNK1/MAPK8-associated membrane protein","ENOG410XSIG,-;KOG3744,Uncharacterized conserved protein","GO:0006986,biological_process,response to unfolded protein;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PLEKHH1",0.724432356,0.060583054,3.512334878,2.349868103,{"v":1.06E-5,"d":"1.06E-05"},{"v":4e-05,"d":"4.00E-05"},"ENSG00000054690","H2R9A1,Uncharacterized protein","XP_016782432.1,pleckstrin homology domain-containing family H member 1 isoform X2","PF00169,PH domain;PF00373,RM central domain;PF00784,MyTH4 domain","IPR019748,FERM central domain;IPR038185,MyTH4 domain superfamily;IPR000299,FERM domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR000857,MyTH4 domain","KOG0248,Cytoplasmic protein Max-1, contains PH, MyTH4 and FERM domains;ENOG410XPCT,-","GO:0005856,cellular_component,cytoskeleton","-"]
["ZNF438",0.946056356,0.076790121,3.491073751,1.549895506,0.003394436,0.007241775,"ENSG00000183621","G3QJN7,Zinc finger protein 438","-","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["ZNF385C",0.451344194,0.036635001,3.491073751,1.549895506,0.003394436,0.007241775,"ENSG00000267221","J9NS58,Chromosome 17 open reading frame 113","XP_013972043.1,-;XP_013972042.1,uncharacterized protein LOC111089969","-","-","ENOG410IVCQ,-;ENOG411201C,-","GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0007275,biological_process,multicellular organism development;GO:0005654,cellular_component,nucleoplasm","-"]
["ZNF17",1.073052225,0.087098204,3.491073751,1.549895506,0.003394436,0.007241775,"ENSG00000186272","G3RPI3,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding","-"]
["TPRG1",0.423368901,0.034364284,3.491073751,1.549895506,0.003394436,0.007241775,"ENSG00000188001","H2QNY4,Tumor protein p63 regulated 1","XP_009445282.1,-;XP_016797982.1,-;XP_009445280.1,-;XP_001159958.1,tumor protein p63-regulated gene 1 protein isoform X1;XP_009445287.1,-","PF12456,Inositol phosphatase","IPR034753,hSac2 domain;IPR022158,Inositol phosphatase","ENOG410IEMY,-;ENOG4110AQ3,-","GO:0005737,cellular_component,cytoplasm","-"]
["GARNL3",0.416381895,0.033797158,3.491073751,1.549895506,0.003394436,0.007241775,"ENSG00000136895","G3RAU2,GTPase activating Rap/RanGAP domain like 3","-","PF02145,Rap/ran-GAP;PF00780,CNH domain","IPR035974,Rap/Ran-GAP superfamily;IPR000331,Rap GTPase activating protein domain;IPR001180,Citron homology (CNH) domain","-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity","-"]
["BEND7",1.161292611,0.100151843,3.490167786,2.829722114,{"v":9.2e-08,"d":"9.20E-08"},{"v":5.44E-7,"d":"5.44E-07"},"ENSG00000165626","H2Q1M7,Uncharacterized protein","-","PF10523,BEN domain","IPR018379,BEN domain","ENOG410XQ7C,-;ENOG410IGCJ,-","-","-"]
["THAP7-AS1",3.831289739,0.330416919,3.490167786,2.829722114,{"v":9.2e-08,"d":"9.20E-08"},{"v":5.44E-7,"d":"5.44E-07"},"ENSG00000230513","G7N363,Tubulin alpha chain","-","PF03953,Tubulin C-terminal domain;PF00091,Tubulin/FtsZ family, GTPase domain","IPR017975,Tubulin, conserved site;IPR003008,Tubulin/FtsZ, GTPase domain;IPR008280,Tubulin/FtsZ, C-terminal;IPR036525,Tubulin/FtsZ, GTPase domain superfamily;IPR037103,Tubulin/FtsZ, C-terminal domain superfamily;IPR018316,Tubulin/FtsZ, 2-layer sandwich domain;IPR002452,Alpha tubulin;IPR000217,Tubulin;IPR023123,Tubulin, C-terminal","KOG1376,Alpha tubulin;COG5023,Tubulin","GO:0005874,cellular_component,microtubule;GO:0005525,molecular_function,GTP binding;GO:0007010,biological_process,cytoskeleton organization;GO:0007017,biological_process,microtubule-based process;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005200,molecular_function,structural constituent of cytoskeleton","-"]
["ZNF195",3.24433199,0.286970963,3.47162695,3.470638782,{"v":1E-10,"d":"1.00E-10"},{"v":1.14E-9,"d":"1.14E-09"},"ENSG00000005801","A0A087WT67,Zinc finger protein 195","XP_011518652.1,zinc finger protein 195 isoform X2;XP_016873750.1,-;XP_011518653.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZHX2",1.611264769,0.138958204,3.468137911,2.313976571,{"v":1.73E-5,"d":"1.73E-05"},{"v":6.27e-05,"d":"6.27E-05"},"ENSG00000178764","H2R9P9,Zinc fingers and homeoboxes 2","XP_519932.2,zinc fingers and homeoboxes protein 2;XP_009454125.1,-;XP_009454127.1,-","PF00046,Homeobox domain","IPR013087,Zinc finger C2H2-type;IPR009057,Homeobox-like domain superfamily;IPR001356,Homeobox domain;IPR036236,Zinc finger C2H2 superfamily","ENOG410IHET,-;ENOG410Z8A2,-","GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0045665,biological_process,negative regulation of neuron differentiation;GO:0003676,molecular_function,nucleic acid binding;GO:0006402,biological_process,mRNA catabolic process;GO:0042803,molecular_function,protein homodimerization activity;GO:0035019,biological_process,somatic stem cell population maintenance;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0003714,molecular_function,transcription corepressor activity;GO:0005886,cellular_component,plasma membrane;GO:0046982,molecular_function,protein heterodimerization activity;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0005654,cellular_component,nucleoplasm","-"]
["GORASP1",1.783987664,0.157127611,3.459886551,2.804418651,{"v":1.46e-07,"d":"1.46E-07"},{"v":8.27e-07,"d":"8.27E-07"},"ENSG00000114745","H2QMB8,Golgi reassembly stacking protein 1, 65kDa","XP_001171913.1,-","PF04495,RASP55/65 PDZ-like domain","IPR024958,GRASP55/65 PDZ-like domain;IPR036034,PDZ superfamily;IPR007583,GRASP55/65","COG5233,Peripheral Golgi membrane protein;KOG3834,Golgi reassembly stacking protein GRASP65, contains PDZ domain","GO:0050774,biological_process,negative regulation of dendrite morphogenesis;GO:0006487,biological_process,protein N-linked glycosylation;GO:0007030,biological_process,Golgi organization;GO:0005794,cellular_component,Golgi apparatus","-"]
["ZNF823",2.993600856,0.266501379,3.422544064,2.277124167,{"v":2.85e-05,"d":"2.85E-05"},{"v":9.78e-05,"d":"9.78E-05"},"ENSG00000197933","B4DUB6,cDNA FLJ56851, highly similar to Zinc finger protein ZFP-36","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["PHC3",12.44914882,1.161995786,3.419082447,6.862944253,{"v":3.49e-36,"d":"3.49E-36"},1.22E-33,"ENSG00000173889","H9ZDR9,Polyhomeotic-like protein 3","XP_001090096.3,-","PF00536,SAM domain (Sterile alpha motif)","IPR038603,FCS-type zinc finger superfamily;IPR012313,Zinc finger, FCS-type;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","ENOG4111F0Y,-;ENOG410IDZN,-","GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["R3HDM1",32.11033618,3.028542858,3.404463267,7.129541875,5.65E-38,{"v":2.11e-35,"d":"2.11E-35"},"ENSG00000048991","K7D7G8,R3H domain containing 1","XP_003309310.2,-","PF01424,R3H domain;PF12752,SUZ domain","IPR001374,R3H domain;IPR024771,SUZ domain;IPR036867,R3H domain superfamily","KOG2953,mRNA-binding protein Encore;ENOG410ZICF,-","GO:0003676,molecular_function,nucleic acid binding","-"]
["NCR3LG1",0.590146369,0.050895223,3.404373038,1.485179374,0.00572059,0.011566962,"ENSG00000188211","H2R5K0,Uncharacterized protein","-","PF07654,Immunoglobulin C1-set domain;PF01140,Matrix protein (MA), p15","IPR003006,Immunoglobulin/major histocompatibility complex, conserved site;IPR000840,Gamma-retroviral matrix protein;IPR036946,Gamma-retroviral matrix domain superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR010999,Retroviral matrix protein;IPR003599,Immunoglobulin subtype;IPR003597,Immunoglobulin C1-set;IPR007110,Immunoglobulin-like domain","ENOG4110NPT,-;ENOG410IKZM,-","GO:0005198,molecular_function,structural molecule activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CTD-2020K17.3",1.656939522,0.142897272,3.404373038,1.485179374,0.00572059,0.011566962,"ENSG00000233175","G3QPF1,Formin like 1","-","PF02181,ormin Homology 2 Domain;PF06367,iaphanous FH3 Domain;PF06371,iaphanous GTPase-binding Domain","IPR027657,Formin-like protein 1;IPR014767,Diaphanous autoregulatory (DAD) domain;IPR015425,Formin, FH2 domain","-","GO:0007010,biological_process,cytoskeleton organization;GO:0008360,biological_process,regulation of cell shape","-"]
["FHOD3",0.477007197,0.041137909,3.404373038,1.485179374,0.00572059,0.011566962,"ENSG00000134775","A0A1D5RJJ5,Formin homology 2 domain containing 3","XP_014977210.1,FH1/FH2 domain-containing protein 3 isoform X2","-","IPR014768,Rho GTPase-binding/formin homology 3 (GBD/FH3) domain;IPR027651,FH1/FH2 domain-containing protein 3;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR014767,Diaphanous autoregulatory (DAD) domain;IPR015425,Formin, FH2 domain","-","GO:0007015,biological_process,actin filament organization","-"]
["RP5-965G21.4",1.627135899,0.140326957,3.404373038,1.485179374,0.00572059,0.011566962,"ENSG00000274414","Q96LS9,cDNA FLJ25101 fis, clone CBR01328","-","-","-","-","-","-"]
["COL6A1",0.711091582,0.061325743,3.404373038,1.485179374,0.00572059,0.011566962,"ENSG00000142156","A0A087X0S5,Collagen alpha-1","-","PF00092,von Willebrand factor type A domain;PF01391,Collagen triple helix repeat (20 copies)","IPR008160,Collagen triple helix repeat;IPR002035,von Willebrand factor, type A;IPR036465,von Willebrand factor A-like domain superfamily","ENOG410ZQTS,-;KOG3544,Collagens (type IV and type XIII), and related proteins","-","-"]
["KDELR3",1.969602034,0.169861817,3.404373038,1.485179374,0.00572059,0.011566962,"ENSG00000100196","K7CX71,ER lumen protein-retaining receptor","XP_009436675.1,-","PF00810,R lumen protein retaining receptor","IPR000133,ER lumen protein retaining receptor","KOG3106,ER lumen protein retaining receptor;COG5196,ER lumen protein retaining receptor","GO:0046923,molecular_function,ER retention sequence binding;GO:0015031,biological_process,protein transport;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0006621,biological_process,protein retention in ER lumen","-"]
["CTC-203F4.2",1.883669968,0.16245089,3.404373038,1.485179374,0.00572059,0.011566962,"-","-","-","-","-","-","-","-"]
["DXO",1.530149949,0.131962725,3.404373038,1.485179374,0.00572059,0.011566962,"ENSG00000204348","A0A024RCW8,DXO","NP_005501.2,decapping and exoribonuclease protein;XP_006715068.1,-","PF08652,RAI1 like PD-(D/E)XK nuclease","IPR013961,RAI1-like","KOG1982,Nuclear 5'-3' exoribonuclease-interacting protein, Rai1p;ENOG410ZAFR,-","GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane;GO:0005634,cellular_component,nucleus","-"]
["SIM1",0.409678922,0.035331404,3.404373038,1.485179374,0.00572059,0.011566962,"ENSG00000112246","G3RLN9,Single-minded family bHLH transcription factor 1","XP_004044499.1,-","PF08447,PAS fold;PF00010,Helix-loop-helix DNA-binding domain;PF00989,PAS fold;PF06621,Single-minded protein C-terminus","IPR000014,PAS domain;IPR010578,Single-minded, C-terminal;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR035965,PAS domain superfamily;IPR013655,PAS fold-3;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR013767,PAS fold;IPR001610,PAC motif","-","GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["RP11-69I8.3",7.675479443,0.661946354,3.404373038,1.485179374,0.00572059,0.011566962,"ENSG00000227220","A0A1D5QFX7,Connective tissue growth factor","-","-","IPR012395,IGFBP-related, CNN;IPR000867,Insulin-like growth factor-binding protein, IGFBP;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR006207,Cystine knot, C-terminal;IPR001007,VWFC domain;IPR006208,Glycoprotein hormone subunit beta;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","-","GO:0001558,biological_process,regulation of cell growth;GO:0005520,molecular_function,insulin-like growth factor binding;GO:0005576,cellular_component,extracellular region","-"]
["RP11-9M16.2",21.96163193,1.894008353,3.404373038,1.485179374,0.00572059,0.011566962,"-","-","-","-","-","-","-","-"]
["FAM160B1",3.399928078,0.316277457,3.403549255,3.652486316,{"v":3.03e-11,"d":"3.03E-11"},{"v":3.92e-10,"d":"3.92E-10"},"ENSG00000151553","H2Q2L9,Family with sequence similarity 160 member B1","XP_016774918.1,protein FAM160B1 isoform X2","PF10257,Retinoic acid induced 16-like protein","IPR019384,Retinoic acid induced 16-like protein","ENOG410IN31,-;ENOG410XTDG,-","-","-"]
["RP11-809N8.4",20.7087336,1.90502003,3.375462147,2.239257616,{"v":4.68e-05,"d":"4.68E-05"},1.53043E-4,"-","-","-","-","-","-","-","-"]
["ENOX1",2.297260354,0.211327601,3.375462147,2.239257616,{"v":4.68e-05,"d":"4.68E-05"},1.53043E-4,"ENSG00000120658","H2Q7I0,Ecto-NOX disulfide-thiol exchanger 1","XP_001153157.1,-;XP_016780754.1,-;XP_003954301.1,-;XP_016780752.1,-;XP_009438847.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR000504,RNA recognition motif domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR035979,RNA-binding domain superfamily;IPR034140,Ecto-NOX disulfide-thiol exchanger, RNA recognition motif","ENOG410IEVY,-;ENOG410XVWG,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005886,cellular_component,plasma membrane","-"]
["RP11-166B2.1",2.620008959,0.241017613,3.375462147,2.239257616,{"v":4.68e-05,"d":"4.68E-05"},1.53043E-4,"ENSG00000234719","A0A0A6YYH2,Uncharacterized protein","-","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);ENOG410J0WZ,-","GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-927P21.5",14.47927715,1.331965224,3.375462147,2.239257616,{"v":4.68e-05,"d":"4.68E-05"},1.53043E-4,"ENSG00000263647","K9J6E0,Putative nucleosome remodeling factor subunit","-","PF15612,WSTF, HB1, Itc1p, MBD9 motif 1;PF00439,Bromodomain;PF00628,PHD-finger;PF02791,T domain;PF15613,Williams-Beuren syndrome DDT (WSD), D-TOX E motif","IPR028941,WHIM2 domain;IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR028942,WHIM1 domain;IPR038028,Nucleosome-remodeling factor subunit BPTF;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR018501,DDT domain;IPR036427,Bromodomain-like superfamily;IPR001487,Bromodomain;IPR019787,Zinc finger, PHD-finger;IPR018359,Bromodomain, conserved site;IPR019786,Zinc finger, PHD-type, conserved site","-","GO:0035064,molecular_function,methylated histone binding;GO:0016589,cellular_component,NURF complex;GO:0046872,molecular_function,metal ion binding","-"]
["ZNF354B",1.899681162,0.174753837,3.375462147,2.239257616,{"v":4.68e-05,"d":"4.68E-05"},1.53043E-4,"ENSG00000178338","A0A1S5UZ15,Zinc finger protein 354B","-","-","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF614",1.797393152,0.16910207,3.365031721,2.725606253,{"v":3.71e-07,"d":"3.71E-07"},{"v":1.9E-6,"d":"1.90E-06"},"ENSG00000142556","H2RDI2,Uncharacterized protein","XP_001174401.1,zinc finger protein 614","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["KLF11",2.225056929,0.214205782,3.331975019,2.6983041,{"v":5.91e-07,"d":"5.91E-07"},{"v":2.94e-06,"d":"2.94E-06"},"ENSG00000172059","Q53QU8,Uncharacterized protein TIEG2","NP_003588.1,Krueppel-like factor 11 isoform a","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0005925,cellular_component,focal adhesion;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:1901653,biological_process,cellular response to peptide;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0005829,cellular_component,cytosol;GO:0016604,cellular_component,nuclear body;GO:0005654,cellular_component,nucleoplasm","-"]
["LDOC1",38.3443971,3.796245562,3.32786698,4.918778071,{"v":4.81e-20,"d":"4.81E-20"},{"v":3.93e-18,"d":"3.93E-18"},"ENSG00000182195","F7IBR8,Uncharacterized protein","XP_008988228.1,-","PF16297,omain of unknown function (DUF4939)","IPR032567,LDOC1-related;IPR032549,Domain of unknown function DUF4939","ENOG410Y6K0,-;ENOG410J3P7,-","-","-"]
["LA16c-407A10.3",4.775550772,0.454456928,3.326791741,2.200319095,{"v":7.68e-05,"d":"7.68E-05"},0.00023831,"ENSG00000282907","E7ERP4,Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q","-","PF05024,N-acetylglucosaminyl transferase component (Gpi1)","IPR007720,N-acetylglucosaminyl transferase component","ENOG410XSXI,-;KOG1183,N-acetylglucosaminyltransferase complex, subunit PIG-Q/GPI1, required for phosphatidylinositol biosynthesis","GO:0017176,molecular_function,phosphatidylinositol N-acetylglucosaminyltransferase activity;GO:0006506,biological_process,GPI anchor biosynthetic process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SP9",2.696297656,0.256588446,3.326791741,2.200319095,{"v":7.68e-05,"d":"7.68E-05"},0.00023831,"ENSG00000217236","H0XXC7,Sp9 transcription factor","XP_003791555.1,transcription factor Sp9","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0030326,biological_process,embryonic limb morphogenesis","-"]
["NPIPB5",3.963602625,0.392999634,3.322889758,4.517826882,5.47E-17,2.55E-15,"ENSG00000243716","E9PKP1,Nuclear pore complex-interacting protein family member B5","-","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);ENOG410J0WZ,-","GO:0005654,cellular_component,nucleoplasm","-"]
["SIMC1",3.002566866,0.295938805,3.315813552,3.3376764,{"v":1.66e-09,"d":"1.66E-09"},{"v":1.45e-08,"d":"1.45E-08"},"ENSG00000170085","F6R0L0,SUMO-interacting motif-containing protein 1","NP_001295124.1,SUMO-interacting motif-containing protein 1 isoform a","-","-","ENOG410IH7J,-;ENOG410XQXC,-","-","-"]
["DYNC1I2P1",1.93792284,0.178271733,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000225137","K9K3Q9,Cytoplasmic dynein 1 intermediate chain-like protein","-","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","ENOG410XQ99,-;KOG1587,Cytoplasmic dynein intermediate chain","-","-"]
["RP11-493P1.2",7.109585188,0.654018852,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000258034","F1RKE1,Mediator of RNA polymerase II transcription subunit 13","-","PF06333,Mediator complex subunit 13 C-terminal","IPR021643,Mediator complex, subunit Med13, N-terminal, metazoa/fungi;IPR009401,Mediator complex, subunit Med13","KOG3600,Thyroid hormone receptor-associated protein complex, subunit TRAP240;ENOG410XPV2,-","GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0016592,cellular_component,mediator complex;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component,nucleus","-"]
["RP11-240G22.5",1.32659299,0.122034803,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000274554","S7MPM1,F-box/WD repeat-containing protein 8","-","PF12937,-box-like","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR036047,F-box-like domain superfamily;IPR001810,F-box domain","-","-","-"]
["FARP1-AS1",11.02756093,1.01443791,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000231194","A0A1D5Q2P2,FERM, ARH/RhoGEF and pleckstrin domain protein 1","-","-","IPR000219,Dbl homology (DH) domain;IPR035899,Dbl homology (DH) domain superfamily","-","GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0065009,biological_process,regulation of molecular function","-"]
["RP11-303E16.2",4.974723714,0.45763051,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000261061","G7NQ99,Uncharacterized protein","-","-","-","-","-","-"]
["AC142472.6",2.045894417,0.188204161,3.312126892,1.417264779,0.009611236,0.018404761,"-","-","-","-","-","-","-","-"]
["SMAD7",0.964762237,0.088749579,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000101665","H2QEI2,Mothers against decapentaplegic homolog","-","PF03165,MH1 domain;PF03166,MH2 domain","IPR003619,MAD homology 1, Dwarfin-type;IPR001132,SMAD domain, Dwarfin-type;IPR013790,Dwarfin;IPR017855,SMAD-like domain superfamily;IPR008984,SMAD/FHA domain superfamily;IPR036578,SMAD MH1 domain superfamily;IPR013019,MAD homology, MH1","ENOG410XQKU,-;KOG3701,TGFbeta receptor signaling protein SMAD and related proteins","GO:0031397,biological_process,negative regulation of protein ubiquitination;GO:0034629,biological_process,cellular protein-containing complex localization;GO:0060389,biological_process,pathway-restricted SMAD protein phosphorylation;GO:0033137,biological_process,negative regulation of peptidyl-serine phosphorylation;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0055117,biological_process,regulation of cardiac muscle contraction;GO:0005518,molecular_function,collagen binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0055010,biological_process,ventricular cardiac muscle tissue morphogenesis;GO:0005886,cellular_component,plasma membrane;GO:0006351,biological_process,transcription, DNA-templated;GO:0022409,biological_process,positive regulation of cell-cell adhesion;GO:0043433,biological_process,negative regulation of DNA binding transcription factor activity;GO:0005634,cellular_component,nucleus;GO:0005913,cellular_component,cell-cell adherens junction;GO:0050821,biological_process,protein stabilization;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0032436,biological_process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0048185,molecular_function,activin binding;GO:0001650,cellular_component,fibrillar center;GO:0008013,molecular_function,beta-catenin binding;GO:2000317,biological_process,negative regulation of T-helper 17 type immune response;GO:0005813,cellular_component,centrosome;GO:0005829,cellular_component,cytosol;GO:0001657,biological_process,ureteric bud development;GO:0030512,biological_process,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060412,biological_process,ventricular septum morphogenesis;GO:0060394,biological_process,negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0003677,molecular_function,DNA binding;GO:0002725,biological_process,negative regulation of T cell cytokine production;GO:0048844,biological_process,artery morphogenesis;GO:0071560,biological_process,cellular response to transforming growth factor beta stimulus;GO:0034616,biological_process,response to laminar fluid shear stress;GO:0030617,molecular_function,transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity;GO:0034333,biological_process,adherens junction assembly;GO:0034713,molecular_function,type I transforming growth factor beta receptor binding;GO:0051444,biological_process,negative regulation of ubiquitin-protein transferase activity;GO:0005654,cellular_component,nucleoplasm;GO:2000320,biological_process,negative regulation of T-helper 17 cell differentiation;GO:0010717,biological_process,regulation of epithelial to mesenchymal transition;GO:0005667,cellular_component,transcription factor complex;GO:0030514,biological_process,negative regulation of BMP signaling pathway;GO:0010944,biological_process,negative regulation of transcription by competitive promoter binding;GO:0016342,cellular_component,catenin complex;GO:0005737,cellular_component,cytoplasm;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0031398,biological_process,positive regulation of protein ubiquitination;GO:0005622,cellular_component,intracellular;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0032925,biological_process,regulation of activin receptor signaling pathway;GO:0010801,biological_process,negative regulation of peptidyl-threonine phosphorylation;GO:0070411,molecular_function,I-SMAD binding","-","`"]
["VMAC",1.580258287,0.145369763,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000187650","H2NX67,Vimentin type intermediate filament associated coiled-coil protein","XP_009250935.1,-","-","-","ENOG410IWFQ,-;ENOG4111J8G,-","-","-"]
["CCDC134",2.804647385,0.258002713,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000100147","G3SFZ7,Coiled-coil domain containing 134","XP_004063595.1,coiled-coil domain-containing protein 134;XP_018874009.1,-","PF15002,RK and JNK pathways, inhibitor","IPR026321,Coiled-coil domain-containing protein 134","-","-","-"]
["CDHR2",0.66602509,0.061268408,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000074276","A0A096NAL5,Cadherin related family member 2","-","PF00028,Cadherin domain","IPR020894,Cadherin conserved site;IPR002126,Cadherin;IPR015919,Cadherin-like","-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ST3GAL6",1.586088757,0.15632798,3.298143087,2.670451332,{"v":9.44e-07,"d":"9.44E-07"},{"v":4.47e-06,"d":"4.47E-06"},"ENSG00000064225","A0A087WXB8,ST3 beta-galactoside alpha-2,3-sialyltransferase 6, isoform CRA_b","NP_001258074.1,type 2 lactosamine alpha-2,3-sialyltransferase isoform 3","PF00777,lycosyltransferase family 29 (sialyltransferase)","IPR012163,Sialyltransferase;IPR038578,GT29-like superfamiliy;IPR001675,Glycosyl transferase family 29","KOG2692,Sialyltransferase;ENOG410XT8P,-","GO:0005794,cellular_component,Golgi apparatus;GO:0097503,biological_process,sialylation;GO:0006486,biological_process,protein glycosylation;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane;GO:0008373,molecular_function,sialyltransferase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["AC004980.7",3.206857267,0.316074063,3.298143087,2.670451332,{"v":9.44e-07,"d":"9.44E-07"},{"v":4.47e-06,"d":"4.47E-06"},"ENSG00000205485","G1RBE6,Uncharacterized protein","-","PF15229,POM121 family","IPR026090,Nuclear pore protein POM121;IPR026054,Nuclear pore complex protein","ENOG410IM0V,-;ENOG4112BJY,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["UCA1",207.9196487,21.23612584,3.290520713,8.048111042,{"v":3.98e-41,"d":"3.98E-41"},{"v":1.64e-38,"d":"1.64E-38"},"ENSG00000273782","Q2VCE5,UCA1 protein","-","-","-","-","-","-"]
["RP5-1050D4.2",15.14552179,1.492771959,3.276421903,2.160245705,{"v":7.68e-05,"d":"7.68E-05"},0.00023831,"ENSG00000234203","G3RRE7,Calmodulin binding transcription activator 2","XP_018868655.1,calmodulin-binding transcription activator 2 isoform X3","PF03859,CG-1 domain;PF01833,IPT/TIG domain","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036770,Ankyrin repeat-containing domain superfamily;IPR014756,Immunoglobulin E-set;IPR020683,Ankyrin repeat-containing domain;IPR005559,CG-1 DNA-binding domain;IPR013783,Immunoglobulin-like fold;IPR000048,IQ motif, EF-hand binding site;IPR002909,IPT domain","-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["RP11-35G9.3",2.773835656,0.273394614,3.276421903,2.160245705,{"v":7.68e-05,"d":"7.68E-05"},0.00023831,"ENSG00000267040","G7MJ96,Uncharacterized protein","-","-","-","-","-","-"]
["RP11-420L9.5",2.408143451,0.237351282,3.276421903,2.160245705,{"v":7.68e-05,"d":"7.68E-05"},0.00023831,"ENSG00000270504","H2PHS7,Uncharacterized protein","-","-","IPR036871,PX domain superfamily","ENOG410IEEQ,-;ENOG411016X,-","GO:0035091,molecular_function,phosphatidylinositol binding","-"]
["EPB41L4B",5.123521348,0.540630129,3.234040484,4.549960416,2.91E-16,1.17E-14,"ENSG00000095203","A0A0D9RGR0,Erythrocyte membrane protein band 4.1 like 4B","XP_007966664.1,band 4.1-like protein 4B isoform X1","PF09379,RM N-terminal domain;PF00373,RM central domain;PF08736,RM adjacent (FA);PF09380,RM C-terminal PH-like domain","IPR019748,FERM central domain;IPR014847,FERM adjacent (FA);IPR030698,Band 4.1-like protein 4B;IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR019747,FERM conserved site;IPR011993,PH-like domain superfamily;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR000798,Ezrin/radixin/moesin-like;IPR029071,Ubiquitin-like domain superfamily","-","GO:0042060,biological_process,wound healing;GO:0010628,biological_process,positive regulation of gene expression;GO:0005737,cellular_component,cytoplasm;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0051549,biological_process,positive regulation of keratinocyte migration;GO:0045785,biological_process,positive regulation of cell adhesion;GO:0005856,cellular_component,cytoskeleton;GO:0031032,biological_process,actomyosin structure organization;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0045177,cellular_component,apical part of cell","-"]
["RP4-761J14.8",12.96676908,1.365833452,3.233484879,4.191202822,{"v":5.77e-14,"d":"5.77E-14"},1.38E-12,"ENSG00000219410","O15420,CAGH1 alternate open reading frame","-","-","-","-","GO:0007399,biological_process,nervous system development;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF708",3.623669269,0.378801671,3.231105327,3.266115151,{"v":5.63e-09,"d":"5.63E-09"},{"v":4.37e-08,"d":"4.37E-08"},"ENSG00000182141","G3QPG8,Zinc finger protein 708","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TRIB1",3.787426193,0.395920064,3.231105327,3.266115151,{"v":5.63e-09,"d":"5.63E-09"},{"v":4.37e-08,"d":"4.37E-08"},"ENSG00000173334","G3QRE4,Tribbles pseudokinase 1","XP_004047569.1,tribbles homolog 1","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR024105,Tribbles homologue 1;IPR024104,Pseudokinase tribbles family/serine-threonine-protein kinase 40;IPR000719,Protein kinase domain","-","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0045659,biological_process,negative regulation of neutrophil differentiation;GO:0048662,biological_process,negative regulation of smooth muscle cell proliferation;GO:0014912,biological_process,negative regulation of smooth muscle cell migration;GO:0008134,molecular_function,transcription factor binding;GO:0004672,molecular_function,protein kinase activity;GO:0043433,biological_process,negative regulation of DNA binding transcription factor activity;GO:0005524,molecular_function,ATP binding;GO:0031434,molecular_function,mitogen-activated protein kinase kinase binding;GO:0004860,molecular_function,protein kinase inhibitor activity;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0032436,biological_process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0005634,cellular_component,nucleus;GO:0043405,biological_process,regulation of MAP kinase activity;GO:0055106,molecular_function,ubiquitin-protein transferase regulator activity;GO:0031665,biological_process,negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0045651,biological_process,positive regulation of macrophage differentiation;GO:0007254,biological_process,JNK cascade;GO:0006468,biological_process,protein phosphorylation;GO:0032496,biological_process,response to lipopolysaccharide;GO:0045645,biological_process,positive regulation of eosinophil differentiation;GO:0005737,cellular_component,cytoplasm","-"]
["ZNF700",2.861827602,0.296170634,3.228001836,2.613000794,{"v":2.41e-06,"d":"2.41E-06"},{"v":1.05e-05,"d":"1.05E-05"},"ENSG00000196757","A0A087WVH9,Zinc finger protein 700","NP_001258777.1,zinc finger protein 700 isoform 2","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF01352,KRAB box;PF13912,C2H2-type zinc finger;PF12874,Zinc-finger of C2H2 type","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF566",1.465577197,0.151672633,3.228001836,2.613000794,{"v":2.41e-06,"d":"2.41E-06"},{"v":1.05e-05,"d":"1.05E-05"},"ENSG00000186017","Q8N2S2,cDNA FLJ90016 fis, clone HEMBA1000671, weakly similar to ZINC FINGER PROTEIN 184","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["SPRR1A",23.74601453,2.42713663,3.224229648,2.118968855,1.26105E-4,0.000373122,"-","-","-","-","-","-","-","-"]
["RP3-523K23.2",3.31682562,0.339020636,3.224229648,2.118968855,1.26105E-4,0.000373122,"-","-","-","-","-","-","-","-"]
["RP1-317E23.3",1.190276417,0.117315949,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000228172","Q96DR3,cDNA FLJ30206 fis, clone BRACE2001508, weakly similar to PROTEIN-LYSINE 6-OXIDASE","-","-","IPR000048,IQ motif, EF-hand binding site","ENOG410KHPX,-;ENOG4110R26,-","GO:0055114,biological_process,oxidation-reduction process;GO:0004720,molecular_function,protein-lysine 6-oxidase activity","-"]
["RP11-618K13.2",8.128220132,0.801133118,3.213577169,1.345819613,0.016084066,0.029148747,"-","-","-","-","-","-","-","-"]
["RP11-521B24.3",1.458728405,0.143775097,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000251602","G7PXF9,Uncharacterized protein","-","-","-","-","-","-"]
["PYGO1",0.386832911,0.038127001,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000171016","F6Y6Y6,Pygopus family PHD finger 1","-","PF00628,PHD-finger","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019786,Zinc finger, PHD-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger","ENOG4111FFC,-;ENOG410IDYF,-","GO:0046872,molecular_function,metal ion binding","-"]
["RP11-667K14.3",7.504383824,0.739646603,3.213577169,1.345819613,0.016084066,0.029148747,"-","-","-","-","-","-","-","-"]
["TEPSIN",0.698118865,0.068807947,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000167302","A0A1B0GV70,AP-4 complex accessory subunit Tepsin","XP_005257124.1,AP-4 complex accessory subunit tepsin isoform X7","PF01417,NTH domain","IPR013809,ENTH  domain;IPR035802,Tepsin, ENTH/VHS domain;IPR008942,ENTH/VHS","-","GO:0031965,cellular_component,nuclear membrane;GO:0005794,cellular_component,Golgi apparatus;GO:0016607,cellular_component,nuclear speck","-"]
["AC006262.6",0.562416179,0.055432828,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000268460","H2NZB0,Uncharacterized protein","-","-","-","-","-","-"]
["MACROD2",0.293057302,0.028884295,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000172264","H2QJZ6,MACRO domain containing 2","XP_001136712.2,O-acetyl-ADP-ribose deacetylase MACROD2","PF01661,Macro domain","IPR002589,Macro domain","COG2110,Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1;KOG2633,Hismacro and SEC14 domain-containing proteins","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0005730,cellular_component,nucleolus;GO:0042278,biological_process,purine nucleoside metabolic process;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0005634,cellular_component,nucleus;GO:0051725,biological_process,protein de-ADP-ribosylation;GO:0005813,cellular_component,centrosome;GO:0007420,biological_process,brain development;GO:0019213,molecular_function,deacetylase activity","-"]
["DGCR5",0.528444132,0.052084477,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000283406","Q9BYB2,KIAA1647 protein","-","-","-","-","-","-"]
["CTC-205M6.1",3.378498002,0.332991306,3.213577169,1.345819613,0.016084066,0.029148747,"-","-","-","-","-","-","-","-"]
["RP11-298A10.1",0.892947095,0.088010595,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000283528","G3S297,Uncharacterized protein","XP_018887359.1,TRPM8 channel-associated factor 2 isoform X2","PF17291,N-terminal domain of M60-like peptidases;PF13402,Peptidase M60, enhancin and enhancin-like","IPR031161,Peptidase family M60 domain;IPR035423,M60-like domain, N-terminal;IPR029062,Class I glutamine amidotransferase-like","-","-","-"]
["AF131216.6",0.567698435,0.055953457,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000246477","A0A0D9RWG6,Myotubularin related protein 9","XP_007959847.1,-","PF06602,Myotubularin-like phosphatase domain","IPR030564,Myotubularin family;IPR029021,Protein-tyrosine phosphatase-like;IPR011993,PH-like domain superfamily;IPR010569,Myotubularin-like phosphatase domain","-","GO:0050821,biological_process,protein stabilization;GO:0060304,biological_process,regulation of phosphatidylinositol dephosphorylation;GO:0010922,biological_process,positive regulation of phosphatase activity;GO:0032991,cellular_component,protein-containing complex;GO:0005737,cellular_component,cytoplasm;GO:0030234,molecular_function,enzyme regulator activity;GO:0019903,molecular_function,protein phosphatase binding;GO:0010507,biological_process,negative regulation of autophagy","-"]
["CA5BP1",1.380009147,0.136016374,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000186312","G3QHC3,Uncharacterized protein","-","PF00194,ukaryotic-type carbonic anhydrase","-","-","-","-"]
["FOCAD",1.537954309,0.163244044,3.209127659,3.247634756,{"v":8.46e-09,"d":"8.46E-09"},{"v":6.32e-08,"d":"6.32E-08"},"ENSG00000188352","H2QX20,Uncharacterized protein","XP_009454651.1,focadhesin isoform X3;XP_016816167.1,-;XP_016816166.1,-","PF11229,ocadhesin;PF12530,Protein of unknown function (DUF3730)","IPR021392,Focadhesin;IPR016024,Armadillo-type fold;IPR022542,Domain of unknown function DUF3730","ENOG410YIIU,-;ENOG410II1D,-","GO:0005925,cellular_component,focal adhesion","-"]
["VLDLR",1.32218948,0.140341983,3.202527309,2.954461689,{"v":3.66e-07,"d":"3.66E-07"},{"v":1.89e-06,"d":"1.89E-06"},"ENSG00000147852","G3QG94,Very low density lipoprotein receptor","XP_004047800.1,very low-density lipoprotein receptor isoform X1","PF14670,Coagulation Factor Xa inhibitory site;PF07645,Calcium-binding EGF domain;PF00057,Low-density lipoprotein receptor domain class A;PF00058,Low-density lipoprotein receptor repeat class B","IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR018097,EGF-like calcium-binding, conserved site;IPR000033,LDLR class B repeat;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR032931,Very low-density lipoprotein receptor;IPR011042,Six-bladed beta-propeller, TolB-like;IPR001881,EGF-like calcium-binding domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR036055,LDL receptor-like superfamily","-","GO:0006898,biological_process,receptor-mediated endocytosis;GO:1900006,biological_process,positive regulation of dendrite development;GO:0034437,molecular_function,glycoprotein transporter activity;GO:0038025,molecular_function,reelin receptor activity;GO:0034436,biological_process,glycoprotein transport;GO:0048813,biological_process,dendrite morphogenesis;GO:0005615,cellular_component,extracellular space;GO:0034447,biological_process,very-low-density lipoprotein particle clearance;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0045860,biological_process,positive regulation of protein kinase activity;GO:0005509,molecular_function,calcium ion binding;GO:0021517,biological_process,ventral spinal cord development;GO:0034185,molecular_function,apolipoprotein binding;GO:0016020,cellular_component,membrane;GO:0048306,molecular_function,calcium-dependent protein binding;GO:0030229,molecular_function,very-low-density lipoprotein particle receptor activity;GO:0043235,cellular_component,receptor complex;GO:0034189,molecular_function,very-low-density lipoprotein particle binding;GO:0016021,cellular_component,integral component of membrane;GO:0038026,biological_process,reelin-mediated signaling pathway","-"]
["FAM86JP",8.484086175,0.910537561,3.200801094,3.683511434,1.04E-10,{"v":1.18e-09,"d":"1.18E-09"},"ENSG00000171084","G3RVZ4,Uncharacterized protein","-","PF14904,amily of unknown function","IPR029426,FAM86","-","-","-"]
["RP3-430N8.11",33.48796921,3.600697199,3.194967908,3.47442212,{"v":5.59e-10,"d":"5.59E-10"},{"v":5.48e-09,"d":"5.48E-09"},"-","-","-","-","-","-","-","-"]
["SMN2",3.088011226,0.327772703,3.191609522,2.583352661,{"v":3.85e-06,"d":"3.85E-06"},{"v":1.61e-05,"d":"1.61E-05"},"ENSG00000205571","E7EQZ4,Survival motor neuron protein","XP_011541901.1,-;XP_011541898.1,survival motor neuron protein isoform X1","PF06003,Survival motor neuron protein (SMN)","IPR002999,Tudor domain;IPR010304,Survival motor neuron","KOG4327,mRNA splicing protein SMN (survival motor neuron);ENOG4111ME8,-","GO:0003723,molecular_function,RNA binding;GO:0005737,cellular_component,cytoplasm;GO:0005634,cellular_component,nucleus;GO:0006397,biological_process,mRNA processing","-"]
["ZNF714",1.891877169,0.203948366,3.186810003,3.228905477,{"v":1.27E-8,"d":"1.27E-08"},{"v":9.18e-08,"d":"9.18E-08"},"ENSG00000160352","A0A087WU35,Zinc finger protein 714","NP_872321.2,zinc finger protein 714","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZBTB49",2.137059113,0.226835199,3.170078137,2.076413561,0.000206996,0.000585857,"ENSG00000168826","H2QP57,Zinc finger and BTB domain containing 49","XP_001154268.1,zinc finger and BTB domain-containing protein 49 isoform X1;XP_009445571.1,-","PF00096,Zinc finger, C2H2 type;PF13912,C2H2-type zinc finger;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0043565,molecular_function,sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0001223,molecular_function,transcription coactivator binding;GO:0008134,molecular_function,transcription factor binding;GO:0007050,biological_process,cell cycle arrest;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0005634,cellular_component,nucleus;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["CTD-2012K14.4",128.4808516,14.24623674,3.158024933,3.983648464,1.43E-12,{"v":2.5e-11,"d":"2.50E-11"},"ENSG00000260894","G1QXS2,RHO family interacting cell polarization regulator 1","-","PF13646,HEAT repeats;PF15903,ilopodia upregulated, FAM65","IPR011989,Armadillo-like helical;IPR026136,RIPOR family member 3;IPR031780,FAM65, N-terminal;IPR016024,Armadillo-type fold","ENOG410IGQR,-;ENOG410ZI73,-","-","-"]
["SH3RF2",5.286377681,0.58899679,3.155635131,4.481774465,{"v":2.05e-15,"d":"2.05E-15"},6.87E-14,"ENSG00000156463","Q08AM8,SH3 domain containing ring finger 2","NP_689763.3,putative E3 ubiquitin-protein ligase SH3RF2","PF07653,Variant SH3 domain;PF14604,Variant SH3 domain;PF00018,SH3 domain;PF13445,RING-type zinc-finger","IPR035792,Putative E3 ubiquitin-protein ligase SH3RF2, first SH3 domain;IPR035822,SH3RF2, third SH3 domain;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001841,Zinc finger, RING-type;IPR035794,Putative E3 ubiquitin-protein ligase SH3RF2, second SH3 domain;IPR001452,SH3 domain;IPR036028,SH3-like domain superfamily;IPR028511,Putative E3 ubiquitin-protein ligase SH3RF2;IPR027370,RING-type zinc-finger, LisH dimerisation motif","ENOG410ITG6,-;ENOG410XS5R,-","GO:0005515,molecular_function,protein binding;GO:0046872,molecular_function,metal ion binding","-"]
["FOXO3B",4.557067103,0.509849759,3.115949409,2.522071974,{"v":9.87e-06,"d":"9.87E-06"},{"v":3.76e-05,"d":"3.76E-05"},"ENSG00000240445","G3RNK9,Forkhead box O3","-","PF00250,orkhead domain;PF16675,KIX-binding domain of forkhead box O, CR2;PF16676,Transactivation domain of FOXO protein family","-","-","-","-"]
["ARL6",1.920862566,0.21490825,3.115949409,2.522071974,{"v":9.87e-06,"d":"9.87E-06"},{"v":3.76e-05,"d":"3.76E-05"},"ENSG00000113966","G1QNA6,ADP ribosylation factor like GTPase 6","-","PF00025,ADP-ribosylation factor family","-","-","-","-"]
["MAN2B2",8.006073678,0.920609814,3.115080687,5.353204489,{"v":1.17e-21,"d":"1.17E-21"},{"v":1.25e-19,"d":"1.25E-19"},"ENSG00000013288","Q4VC00,Alpha-mannosidase","-","PF01074,lycosyl hydrolases family 38 N-terminal domain;PF07748,lycosyl hydrolases family 38 C-terminal domain;PF09261,Alpha mannosidase middle domain","IPR000602,Glycoside hydrolase family 38, N-terminal domain;IPR011013,Galactose mutarotase-like domain superfamily;IPR037094,Glycoside hydrolase family 38, central domain superfamily;IPR027291,Glycoside hydrolase 38, N-terminal domain superfamily;IPR011330,Glycoside hydrolase/deacetylase, beta/alpha-barrel;IPR013780,Glycosyl hydrolase, all-beta;IPR015341,Glycoside hydrolase family 38, central domain;IPR011682,Glycosyl hydrolase family 38, C-terminal;IPR028995,Glycoside hydrolase families 57/38, central domain superfamily","KOG1959,Glycosyl hydrolase, family 38 - alpha-mannosidase;ENOG410XQMZ,-","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0005975,biological_process,carbohydrate metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0006013,biological_process,mannose metabolic process;GO:0003824,molecular_function,catalytic activity;GO:0046872,molecular_function,metal ion binding;GO:0030246,molecular_function,carbohydrate binding;GO:0008152,biological_process,metabolic process;GO:0004559,molecular_function,alpha-mannosidase activity","-"]
["RP11-572N21.1",1.897252679,0.209436526,3.113814515,2.032497628,0.000339552,0.000912103,"ENSG00000280414","H0XXC7,Sp9 transcription factor","XP_003791555.1,transcription factor Sp9","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0030326,biological_process,embryonic limb morphogenesis","-"]
["ZNF273",0.686142352,0.075742821,3.113814515,2.032497628,0.000339552,0.000912103,"ENSG00000198039","H2QUM9,Zinc finger protein 273","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["MAN1C1",0.342009959,0.036302176,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000117643","G3R750,alpha-1,2-Mannosidase","XP_004025245.2,mannosyl-oligosaccharide 1,2-alpha-mannosidase IC","PF01532,lycosyl hydrolase family 47","IPR012341,Six-hairpin glycosidase-like superfamily;IPR036026,Seven-hairpin glycosidases;IPR001382,Glycoside hydrolase family 47","-","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0016787,molecular_function,hydrolase activity;GO:0004571,molecular_function,mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0003824,molecular_function,catalytic activity;GO:0005509,molecular_function,calcium ion binding;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["RP5-862P8.3",9.527721879,1.011306929,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000251508","H2N3D8,Pecanex homolog 2","-","PF05041,Pecanex protein (C-terminus)","IPR007735,Pecanex","KOG3604,Pecanex;ENOG4111D2H,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["AL356053.1",1.060454101,0.112560441,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000150076","H2RBE8,Uncharacterized protein","XP_009456495.2,trichohyalin isoform X6","-","IPR029272,Coiled-coil domain-containing protein 7","ENOG41117EC,-;ENOG410J0QB,-","-","-"]
["ACSL5",0.728749266,0.077352088,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000197142","H2R2B0,Acyl-CoA synthetase long-chain family member 5","XP_001146649.1,long-chain-fatty-acid--CoA ligase 5 isoform X1","PF00501,AMP-binding enzyme","IPR000873,AMP-dependent synthetase/ligase;IPR020845,AMP-binding, conserved site","KOG1256,Long-chain acyl-CoA synthetases (AMP-forming);COG1022,Long-chain acyl-CoA synthetases (AMP-forming)","GO:0005730,cellular_component,nucleolus;GO:0003824,molecular_function,catalytic activity;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","-"]
["RP11-129M16.4",1.987753953,0.210987408,3.107798762,1.270457515,0.007880255,0.015382938,"-","-","-","-","-","-","-","-"]
["KIAA1024",0.453967925,0.048185801,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000169330","H2Q9X4,KIAA1024","XP_001154012.1,UPF0258 protein KIAA1024 homolog isoform X1","PF06789,Uncharacterised protein family (UPF0258)","IPR009626,Uncharacterised protein family UPF0258","ENOG410ZD1X,-;ENOG410IFF3,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MMP28",1.080119625,0.114647811,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000271447","H2NTE2,Matrix metallopeptidase 28","-","PF00413,Matrixin;PF01471,Putative peptidoglycan binding domain;PF00045,Hemopexin","IPR001818,Peptidase M10, metallopeptidase;IPR028735,Matrix metalloproteinase-28;IPR036375,Hemopexin-like domain superfamily;IPR036365,PGBD-like superfamily;IPR021190,Peptidase M10A;IPR000585,Hemopexin-like domain;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR006026,Peptidase, metallopeptidase;IPR018487,Hemopexin-like repeats;IPR033739,Peptidase M10A, catalytic domain;IPR002477,Peptidoglycan binding-like","KOG1565,Gelatinase A and related matrix metalloproteases;ENOG410XQ5D,-","GO:0006508,biological_process,proteolysis;GO:0010760,biological_process,negative regulation of macrophage chemotaxis;GO:0016787,molecular_function,hydrolase activity;GO:0005578,,;GO:0005737,cellular_component,cytoplasm;GO:0008237,molecular_function,metallopeptidase activity;GO:0031012,cellular_component,extracellular matrix;GO:0046872,molecular_function,metal ion binding;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0008233,molecular_function,peptidase activity;GO:0008270,molecular_function,zinc ion binding","-"]
["AC002117.1",4.435318806,0.470780812,3.107798762,1.270457515,0.007880255,0.015382938,"-","-","-","-","-","-","-","-"]
["RP11-318A15.7",6.444638598,0.684057297,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000267168","K7EN84,Uncharacterized protein","-","PF10294,Lysine methyltransferase","IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR019410,Lysine methyltransferase","COG0500,SAM-dependent methyltransferases;KOG2793,Putative N2,N2-dimethylguanosine tRNA methyltransferase","-","-"]
["ZNF799",0.61067891,0.064819673,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000196466","M0R135,Uncharacterized protein","-","PF01352,KRAB box","IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF443",1.121315615,0.119020503,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000180855","B4DS18,cDNA FLJ59243, highly similar to Zinc finger protein 443","-","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["AC009299.2",1.012789334,0.10750113,3.107798762,1.270457515,0.007880255,0.015382938,"-","-","-","-","-","-","-","-"]
["DZANK1",0.466381914,0.049503467,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000089091","A1L3Z8,C20orf12 protein","NP_001092877.1,double zinc ribbon and ankyrin repeat-containing protein 1 isoform 3","PF12773,ouble zinc ribbon;PF13287,n3 associated","IPR020683,Ankyrin repeat-containing domain;IPR026876,Fn3 associated repeat;IPR025874,Double zinc ribbon;IPR036770,Ankyrin repeat-containing domain superfamily","ENOG410XPI2,-;ENOG410IEZB,-","-","-"]
["CPSF1P1",0.827609085,0.087845428,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000214076","A0A0D9R822,Cleavage and polyadenylation specific factor 1","XP_008000112.1,cleavage and polyadenylation specificity factor subunit 1 isoform X2","PF10433,Mono-functional DNA-alkylating methyl methanesulfonate N-term;PF03178,CPSF A subunit region","IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR004871,Cleavage/polyadenylation specificity factor, A subunit, C-terminal","-","GO:0019899,molecular_function,enzyme binding;GO:0005847,cellular_component,mRNA cleavage and polyadenylation specificity factor complex;GO:0003676,molecular_function,nucleic acid binding;GO:0035925,molecular_function,mRNA 3'-UTR AU-rich region binding;GO:0006378,biological_process,mRNA polyadenylation;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["CHDH",0.397909498,0.042235556,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000016391","A0A024R301,Choline dehydrogenase, isoform CRA_a","-","PF00732,MC oxidoreductase;PF05834,Lycopene cyclase protein;PF05199,MC oxidoreductase","IPR027424,Glucose Oxidase, domain 2;IPR012132,Glucose-methanol-choline oxidoreductase;IPR036188,FAD/NAD(P)-binding domain superfamily;IPR000172,Glucose-methanol-choline oxidoreductase, N-terminal;IPR007867,Glucose-methanol-choline oxidoreductase, C-terminal","COG2303,Choline dehydrogenase and related flavoproteins;KOG1238,Glucose dehydrogenase/choline dehydrogenase/mandelonitrile lyase (GMC oxidoreductase family)","GO:0055114,biological_process,oxidation-reduction process;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0016614,molecular_function,oxidoreductase activity, acting on CH-OH group of donors","-"]
["CTD-2228K2.7",0.717569012,0.076165375,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000225138","B4DKV9,cDNA FLJ60648","-","-","-","-","-","-"]
["AC073130.1",1.2058523,0.127993533,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000237870","A4D0U4,Uncharacterized protein LOC286009","-","-","IPR036691,Endonuclease/exonuclease/phosphatase superfamily","-","-","-"]
["BLNK",7.016606208,0.806832013,3.105626576,3.938831505,{"v":3.93e-12,"d":"3.93E-12"},{"v":6.2e-11,"d":"6.20E-11"},"ENSG00000095585","B3KNL5,cDNA FLJ14873 fis, clone PLACE1002685, highly similar to B-cell linker protein","-","PF00017,SH2 domain","IPR036860,SH2 domain superfamily;IPR000980,SH2 domain","ENOG410XYB6,-;ENOG410IGWN,-","-","-"]
["C5",1.744694164,0.200620508,3.087384252,2.859478701,{"v":1.33E-6,"d":"1.33E-06"},{"v":6.15e-06,"d":"6.15E-06"},"ENSG00000106804","H2QXT1,Uncharacterized protein","XP_520228.2,complement C5 isoform X2","PF01821,Anaphylotoxin-like domain;PF07678,A-macroglobulin complement component;PF01759,UNC-6/NTR/C345C module;PF01835,MG2 domain;PF07703,Alpha-2-macroglobulin family N-terminal region;PF00207,Alpha-2-macroglobulin family;PF07677,A-macroglobulin receptor","IPR008993,Tissue inhibitor of metalloproteinases-like, OB-fold;IPR001599,Alpha-2-macroglobulin;IPR011626,Alpha-macroglobulin complement component;IPR018081,Anaphylatoxin, complement system;IPR009048,Alpha-macroglobulin, receptor-binding;IPR000020,Anaphylatoxin/fibulin;IPR037562,Complement C5;IPR002890,Alpha-2-macroglobulin, N-terminal;IPR001134,Netrin domain;IPR018933,Netrin module, non-TIMP type;IPR013783,Immunoglobulin-like fold;IPR001840,Anaphylatoxin, complement system domain;IPR036595,Alpha-macroglobulin, receptor-binding domain superfamily;IPR011625,Alpha-2-macroglobulin, N-terminal 2;IPR008930,Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid","ENOG410XRED,-;KOG1366,Alpha-macroglobulin","GO:0004866,molecular_function,endopeptidase inhibitor activity;GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0010760,biological_process,negative regulation of macrophage chemotaxis;GO:0006956,biological_process,complement activation;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0001701,biological_process,in utero embryonic development;GO:0010575,biological_process,positive regulation of vascular endothelial growth factor production;GO:0006954,biological_process,inflammatory response;GO:0005615,cellular_component,extracellular space;GO:0005579,cellular_component,membrane attack complex;GO:0005576,cellular_component,extracellular region;GO:0090197,biological_process,positive regulation of chemokine secretion","-"]
["ZNF230",1.357346019,0.156079761,3.076577422,2.490378168,{"v":9.87e-06,"d":"9.87E-06"},{"v":3.76e-05,"d":"3.76E-05"},"ENSG00000159882","H2QGI8,Uncharacterized protein","XP_001158754.1,zinc finger protein 230 isoform X2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ADGRF4",4.131568438,0.483136899,3.069729309,3.131273976,{"v":6.58e-08,"d":"6.58E-08"},{"v":4.03E-7,"d":"4.03E-07"},"ENSG00000153294","A0A0C4DFV3,Adhesion G protein-coupled receptor F4","-","PF00002,7 transmembrane receptor (Secretin family);PF01825,PCR proteolysis site, GPS, motif","IPR000832,GPCR, family 2, secretin-like;IPR000203,GPS motif;IPR017981,GPCR, family 2-like;IPR008078,GPCR family 2, Ig-hepta-like receptor","ENOG410XSD2,-;KOG4193,G protein-coupled receptors","GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0016020,cellular_component,membrane;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["CHAMP1",7.287196978,0.864132797,3.063959795,4.174717643,{"v":4.45e-13,"d":"4.45E-13"},{"v":8.76e-12,"d":"8.76E-12"},"ENSG00000198824","H2R2U0,Chromosome alignment maintaining phosphoprotein 1","XP_001141584.1,chromosome alignment-maintaining phosphoprotein 1;XP_003318217.2,-;XP_009439465.1,-","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","ENOG410XXII,-;ENOG410IFC8,-","GO:0031134,biological_process,sister chromatid biorientation;GO:0003676,molecular_function,nucleic acid binding;GO:0005819,cellular_component,spindle;GO:0034501,biological_process,protein localization to kinetochore;GO:0051315,biological_process,attachment of mitotic spindle microtubules to kinetochore;GO:0035372,biological_process,protein localization to microtubule;GO:0000777,cellular_component,condensed chromosome kinetochore","-"]
["ZNF124",4.889039963,0.580320469,3.058055636,3.740373334,1.13E-10,{"v":1.27E-9,"d":"1.27E-09"},"ENSG00000196418","G1QW29,Zinc finger protein 124","-","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF01352,KRAB box","-","-","-","-"]
["PIK3C2G",0.96186388,0.110603695,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000139144","F5H369,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma","NP_001275701.1,phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 1","PF00792,Phosphoinositide 3-kinase C2;PF00787,PX domain;PF00454,Phosphatidylinositol 3- and 4-kinase;PF00613,Phosphoinositide 3-kinase family, accessory domain (PIK domain);PF00168,C2 domain;PF00794,PI3-kinase family, ras-binding domain","IPR018936,Phosphatidylinositol 3/4-kinase, conserved site;IPR000341,Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain;IPR036871,PX domain superfamily;IPR000403,Phosphatidylinositol 3-/4-kinase, catalytic domain;IPR015433,Phosphatidylinositol kinase;IPR037707,PI3K-C2-gamma, catalytic domain;IPR036940,Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily;IPR016024,Armadillo-type fold;IPR011009,Protein kinase-like domain superfamily;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR001683,Phox homologous domain;IPR029071,Ubiquitin-like domain superfamily;IPR001263,Phosphoinositide 3-kinase, accessory (PIK) domain;IPR002420,Phosphatidylinositol 3-kinase, C2 domain","KOG0905,Phosphoinositide 3-kinase;COG5032,Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family","GO:0016301,molecular_function,kinase activity;GO:0035005,molecular_function,1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0016740,molecular_function,transferase activity;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0035004,molecular_function,phosphatidylinositol 3-kinase activity;GO:0005622,cellular_component,intracellular;GO:0048015,biological_process,phosphatidylinositol-mediated signaling;GO:0016310,biological_process,phosphorylation;GO:0046854,biological_process,phosphatidylinositol phosphorylation","-"]
["RP11-582E3.6",3.062355447,0.352136964,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000275764","L0W7A2,RNA-directed DNA polymerase","WP_008930570.1,RNA-directed DNA polymerase, partial","PF08333,Protein of unknown function (DUF1725);PF00078,Reverse transcriptase (RNA-dependent DNA polymerase)","IPR013544,Domain of unknown function DUF1725;IPR000477,Reverse transcriptase domain","-","GO:0003964,molecular_function,RNA-directed DNA polymerase activity;GO:0006278,biological_process,RNA-dependent DNA biosynthetic process","-"]
["MIP",1.702223264,0.195736825,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000135517","G3RKA2,Major intrinsic protein of lens fiber","XP_004053430.1,-","PF00230,Major intrinsic protein","IPR023271,Aquaporin-like;IPR000425,Major intrinsic protein;IPR034294,Aquaporin transporter;IPR022357,Major intrinsic protein, conserved site","-","GO:0005212,molecular_function,structural constituent of eye lens;GO:0015267,molecular_function,channel activity;GO:0055085,biological_process,transmembrane transport;GO:0045785,biological_process,positive regulation of cell adhesion;GO:1990349,biological_process,gap junction-mediated intercellular transport;GO:0005783,cellular_component,endoplasmic reticulum;GO:0051289,biological_process,protein homotetramerization;GO:0006833,biological_process,water transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0015250,molecular_function,water channel activity;GO:0002088,biological_process,lens development in camera-type eye;GO:0007601,biological_process,visual perception;GO:0016021,cellular_component,integral component of membrane","-"]
["CTB-134H23.2",4.209042457,0.483993272,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000196796","E9PS57,Nuclear pore complex-interacting protein family member B6","XP_016879119.1,-;XP_005255798.1,nuclear pore complex-interacting protein family member B6 isoform X4","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","-","GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-67A1.2",10.38077138,1.193673753,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000261864","H3BR83,Nuclear factor of-activated T-cells, cytoplasmic 3","-","PF00554,Rel homology DNA-binding domain;PF16179,Rel homology dimerisation domain","IPR011539,Rel homology domain (RHD), DNA-binding domain;IPR008967,p53-like transcription factor, DNA-binding;IPR032397,Rel homology dimerisation domain;IPR008366,Nuclear factor of activated T cells (NFAT);IPR037059,Rel homology domain (RHD), DNA-binding domain superfamily;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set;IPR002909,IPT domain","ENOG4111EMW,-;ENOG410IIAD,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005654,cellular_component,nucleoplasm","-"]
["CTC-529I10.2",7.10603926,0.817115823,3.055267312,1.987130695,0.000556462,0.001426661,"-","-","-","-","-","-","-","-"]
["RP11-458J1.1",4.016239244,0.461823037,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000278834","I7G8L2,Macaca fascicularis brain cDNA clone: QmoA-11833, similar to human chemokine","-","-","-","-","-","-"]
["MGAT5B",0.89242773,0.102619306,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000167889","G3RAM8,Mannosyl","XP_004040964.2,alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X2","PF15024,lycosyltransferase family 18","IPR026116,Glycosyltransferase family 18","-","GO:0030144,molecular_function,alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity;GO:0006487,biological_process,protein N-linked glycosylation;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF549",0.614187249,0.070624732,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000121406","H2P0D5,Zinc finger protein 549","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["RP11-503P10.1",8.648017431,0.994426237,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000272056","H2P6Q5,ATP/GTP binding protein like 5","XP_002812245.1,cytosolic carboxypeptidase-like protein 5","PF00246,Zinc carboxypeptidase","IPR000834,Peptidase M14, carboxypeptidase A;IPR034286,Cytosolic carboxypeptidase-like protein 5 catalytic domain","KOG3641,Zinc carboxypeptidase;COG2866,Predicted carboxypeptidase","GO:0030496,cellular_component,midbody;GO:0051607,biological_process,defense response to virus;GO:0035608,biological_process,protein deglutamylation;GO:0006508,biological_process,proteolysis;GO:0005737,cellular_component,cytoplasm;GO:0045171,cellular_component,intercellular bridge;GO:0015631,molecular_function,tubulin binding;GO:0004181,molecular_function,metallocarboxypeptidase activity;GO:0035611,biological_process,protein branching point deglutamylation;GO:0005829,cellular_component,cytosol;GO:0072686,cellular_component,mitotic spindle;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["RP4-800J21.3",3.700677589,0.425536942,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000218018","Q8N1N1,cDNA FLJ39107 fis, clone NTONG2005062","-","-","-","-","-","-"]
["AP1S2",1.044929132,0.120155279,3.055267312,1.987130695,0.000556462,0.001426661,"ENSG00000182287","A0A096NA58,AP complex subunit sigma","XP_017809514.1,-;XP_017809513.1,-","PF01217,Clathrin adaptor complex small chain","IPR011012,Longin-like domain superfamily;IPR022775,AP complex, mu/sigma subunit;IPR000804,Clathrin adaptor complex, small chain;IPR016635,Adaptor protein complex, sigma subunit","-","GO:0015031,biological_process,protein transport;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0030117,cellular_component,membrane coat;GO:0008565,molecular_function,protein transporter activity;GO:0006886,biological_process,intracellular protein transport","-"]
["TRAF3IP2",9.928899711,1.200049242,3.043002373,5.233083012,{"v":4.14e-20,"d":"4.14E-20"},{"v":3.43e-18,"d":"3.43E-18"},"ENSG00000056972","H2QTK6,Uncharacterized protein","-","PF08357,SEFIR domain","IPR013568,SEFIR domain","ENOG410IF9W,-;ENOG4111GTJ,-","GO:0006959,biological_process,humoral immune response;GO:0001783,biological_process,B cell apoptotic process;GO:0005102,molecular_function,signaling receptor binding;GO:0002230,biological_process,positive regulation of defense response to virus by host;GO:0048305,biological_process,immunoglobulin secretion;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling","-"]
["CABLES2",10.66531696,1.298534128,3.029132352,4.569028876,{"v":2.3e-15,"d":"2.30E-15"},{"v":7.57e-14,"d":"7.57E-14"},"ENSG00000149679","H2R8T8,Uncharacterized protein","-","PF00134,Cyclin, N-terminal domain","IPR013763,Cyclin-like;IPR012388,CDK5 and ABL1 enzyme substrate 1/2;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","KOG4164,Cyclin ik3-1/CABLES;ENOG4110WYV,-","GO:0051726,biological_process,regulation of cell cycle","-"]
["ZNF107",2.984000709,0.366002173,3.010824757,3.700491569,3.28E-10,{"v":3.37e-09,"d":"3.37E-09"},"ENSG00000196247","G3QH98,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding","-"]
["RP11-316M1.12",57.99155219,7.159741088,3.010076256,4.72520543,{"v":1.46e-16,"d":"1.46E-16"},{"v":6.21e-15,"d":"6.21E-15"},"-","-","-","-","-","-","-","-"]
["GLUD2",0.952507602,0,6.129041833,0.910905805,0.004642655,0.009589815,"ENSG00000182890","A0A140VK14,Testicular secretory protein Li 14","NP_036216.2,glutamate dehydrogenase 2, mitochondrial precursor","PF00208,lutamate/Leucine/Phenylalanine/Valine dehydrogenase;PF02812,lu/Leu/Phe/Val dehydrogenase, dimerisation domain","IPR036291,NAD(P)-binding domain superfamily;IPR006096,Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal;IPR033922,NAD(P) binding domain of glutamate dehydrogenase;IPR006097,Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain;IPR033524,Leu/Phe/Val dehydrogenases active site;IPR006095,Glutamate/phenylalanine/leucine/valine dehydrogenase","-","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0006520,biological_process,cellular amino acid metabolic process;GO:0005739,cellular_component,mitochondrion;GO:0016639,molecular_function,oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor","K00261,ko00250,Alanine, aspartate and glutamate metabolism;K00261,ko01200,Carbon metabolism;K00261,ko04964,Proximal tubule bicarbonate reclamation;K00261,ko00220,Arginine biosynthesis;K00261,ko00910,Nitrogen metabolism;K00261,ko00471,D-Glutamine and D-glutamate metabolism"]
["B3GALNT1",0.454143237,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000169255","K6ZKE2,Hexosyltransferase","XP_009445047.2,-;XP_016797741.1,-;XP_009445045.2,-;XP_016797742.1,-;XP_003310123.2,beta-1,3-N-acetylgalactosaminyltransferase 1;XP_003310130.2,-","PF01762,alactosyltransferase","IPR002659,Glycosyl transferase, family 31","ENOG410ZZ1B,-;KOG2287,Galactosyltransferases","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0008378,molecular_function,galactosyltransferase activity;GO:0006486,biological_process,protein glycosylation;GO:0005794,cellular_component,Golgi apparatus;GO:0016740,molecular_function,transferase activity;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K00719,ko00603,Glycosphingolipid biosynthesis - globo series"]
["RP11-421N8.1",4.297921182,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000260747","G3QR73,ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1","XP_004026390.1,ATP synthase F(0) complex subunit B1, mitochondrial","PF05405,Mitochondrial ATP synthase B chain precursor (ATP-synt_B)","IPR008688,ATP synthase, F0 complex, subunit B/MI25;IPR013837,ATP synthase, F0 complex, subunit B","-","GO:0015986,biological_process,ATP synthesis coupled proton transport;GO:0000276,cellular_component,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0015078,molecular_function,proton transmembrane transporter activity","K02127,ko00190,Oxidative phosphorylation;K02127,ko05016,Huntington's disease;K02127,ko05012,Parkinson's disease;K02127,ko05010,Alzheimer's disease"]
["BHLHE41",1.263085879,0.082994794,3.793603169,1.782006921,0.000700954,0.001751352,"ENSG00000123095","H2Q5M4,Uncharacterized protein","XP_520805.2,-","PF00010,Helix-loop-helix DNA-binding domain;PF07527,Hairy Orange","IPR003650,Orange domain;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","KOG4304,Transcriptional repressors of the hairy/E(spl) family (contains HLH);ENOG4111F0X,-","GO:0003705,molecular_function,transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0046983,molecular_function,protein dimerization activity;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003714,molecular_function,transcription corepressor activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005634,cellular_component,nucleus;GO:0042826,molecular_function,histone deacetylase binding;GO:0032922,biological_process,circadian regulation of gene expression;GO:0042803,molecular_function,protein homodimerization activity;GO:0010832,biological_process,negative regulation of myotube differentiation;GO:0043425,molecular_function,bHLH transcription factor binding;GO:0007623,biological_process,circadian rhythm;GO:0003677,molecular_function,DNA binding;GO:0070888,molecular_function,E-box binding;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001102,molecular_function,RNA polymerase II activating transcription factor binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043426,molecular_function,MRF binding;GO:0010944,biological_process,negative regulation of transcription by competitive promoter binding;GO:0001191,molecular_function,transcriptional repressor activity, RNA polymerase II transcription factor binding","K03730,ko04710,Circadian rhythm"]
["ADRA2C",1.634649922,0,6.707116794,1.338042713,0.000352487,0.000943384,"ENSG00000184160","G1SAI1,Adrenoceptor alpha 2C","-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR000276,G protein-coupled receptor, rhodopsin-like;IPR002233,Adrenoceptor family;IPR000735,Alpha 2C adrenoceptor;IPR017452,GPCR, rhodopsin-like, 7TM","ENOG410XRW9,-;KOG3656,FOG: 7 transmembrane receptor","GO:0071875,biological_process,adrenergic receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0004938,molecular_function,alpha2-adrenergic receptor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004935,molecular_function,adrenergic receptor activity;GO:0004871,molecular_function,signal transducer activity;GO:0006940,biological_process,regulation of smooth muscle contraction;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0030168,biological_process,platelet activation;GO:0019229,biological_process,regulation of vasoconstriction;GO:0016021,cellular_component,integral component of membrane","K04140,ko04080,Neuroactive ligand-receptor interaction;K04140,ko04022,cGMP-PKG signaling pathway"]
["TRPM6",0.490780242,0.035642711,3.650253927,1.670845564,0.001187534,0.002821641,"ENSG00000119121","H2R0H5,Uncharacterized protein","-","PF16519,Tetramerisation domain of TRPM;PF00520,Ion transport protein;PF02816,Alpha-kinase family","IPR004166,MHCK/EF2 kinase;IPR011009,Protein kinase-like domain superfamily;IPR032415,TRPM, tetramerisation domain;IPR005821,Ion transport domain;IPR029597,Transient receptor potential cation channel subfamily M member 6;IPR037162,TRPM, tetramerisation domain superfamily","ENOG410INBW,-;ENOG410ZSH9,-","GO:0005216,molecular_function,ion channel activity;GO:0051262,biological_process,protein tetramerization;GO:0005261,molecular_function,cation channel activity;GO:0055085,biological_process,transmembrane transport;GO:0006812,biological_process,cation transport;GO:0006811,biological_process,ion transport;GO:0098655,biological_process,cation transmembrane transport;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0016020,cellular_component,membrane;GO:0034220,biological_process,ion transmembrane transport;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","K04981,ko04978,Mineral absorption"]
["WASF1",8.522342637,0.904592333,3.220955038,4.03773267,{"v":2.68e-13,"d":"2.68E-13"},{"v":5.62e-12,"d":"5.62E-12"},"ENSG00000112290","F7AUN9,WAS protein family member 1","XP_002747049.1,wiskott-Aldrich syndrome protein family member 1","PF02205,WH2 motif","IPR003124,WH2 domain;IPR028288,SCAR/WAVE family","ENOG410XRBQ,-;KOG1830,Wiskott Aldrich syndrome proteins","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0031209,cellular_component,SCAR complex;GO:0005741,cellular_component,mitochondrial outer membrane;GO:2000601,biological_process,positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0030036,biological_process,actin cytoskeleton organization;GO:0005737,cellular_component,cytoplasm;GO:0051388,biological_process,positive regulation of neurotrophin TRK receptor signaling pathway;GO:0072673,biological_process,lamellipodium morphogenesis;GO:0032991,cellular_component,protein-containing complex;GO:0044877,molecular_function,protein-containing complex binding;GO:0030027,cellular_component,lamellipodium;GO:0005856,cellular_component,cytoskeleton;GO:0016601,biological_process,Rac protein signal transduction;GO:0048365,molecular_function,Rac GTPase binding;GO:0005739,cellular_component,mitochondrion;GO:0051018,molecular_function,protein kinase A binding;GO:0097484,biological_process,dendrite extension;GO:0031175,biological_process,neuron projection development;GO:1990416,biological_process,cellular response to brain-derived neurotrophic factor stimulus;GO:0003779,molecular_function,actin binding","K05753,ko04810,Regulation of actin cytoskeleton;K05753,ko04666,Fc gamma R-mediated phagocytosis;K05753,ko05131,Shigellosis;K05753,ko04520,Adherens junction;K05753,ko05132,Salmonella infection;K05753,ko05100,Bacterial invasion of epithelial cells;K05753,ko05231,Choline metabolism in cancer"]
["TICAM1",11.44706978,1.346897569,3.0751744,4.184323122,{"v":3.26e-13,"d":"3.26E-13"},{"v":6.65e-12,"d":"6.65E-12"},"ENSG00000127666","G3QUW7,Toll like receptor adaptor molecule 1","-","PF12721,RIP homotypic interaction motif","IPR025735,RHIM domain;IPR017278,TIR domain-containing adapter molecule 1;IPR035897,Toll/interleukin-1 receptor homology (TIR) domain superfamily","-","GO:0045087,biological_process,innate immune response;GO:0007165,biological_process,signal transduction;GO:0004871,molecular_function,signal transducer activity","K05842,ko04064,NF-kappa B signaling pathway;K05842,ko05161,Hepatitis B;K05842,ko05133,Pertussis;K05842,ko05168,Herpes simplex infection;K05842,ko05160,Hepatitis C;K05842,ko04620,Toll-like receptor signaling pathway;K05842,ko05164,Influenza A;K05842,ko05142,Chagas disease (American trypanosomiasis)"]
["MAML3",1.523917076,0.093457914,3.958110391,2.72044729,{"v":7.82e-08,"d":"7.82E-08"},{"v":4.7E-7,"d":"4.70E-07"},"ENSG00000196782","F6RJ30,Mastermind like transcriptional coactivator 3","XP_001088303.2,mastermind-like protein 3","-","IPR019082,Neurogenic mastermind-like, N-terminal","ENOG410ZYVU,-;ENOG410IJ3G,-","GO:0003713,molecular_function,transcription coactivator activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0007219,biological_process,Notch signaling pathway;GO:0016607,cellular_component,nuclear speck;GO:0007221,biological_process,positive regulation of transcription of Notch receptor target;GO:0005634,cellular_component,nucleus","K06061,ko04330,Notch signaling pathway"]
["ITGA1",0.140690596,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000213949","H2QQV4,Integrin, alpha 1","XP_517769.2,integrin alpha-1","PF01839,-GAP repeat;PF08441,Integrin alpha;PF00092,von Willebrand factor type A domain","IPR013517,FG-GAP repeat;IPR036465,von Willebrand factor A-like domain superfamily;IPR018184,Integrin alpha chain, C-terminal cytoplasmic region, conserved site;IPR032695,Integrin domain superfamily;IPR013649,Integrin alpha-2;IPR013519,Integrin alpha beta-propellor;IPR000413,Integrin alpha chain;IPR002035,von Willebrand factor, type A;IPR028994,Integrin alpha, N-terminal","ENOG410YEM8,-;ENOG410IPB7,-","GO:0008305,cellular_component,integrin complex;GO:0009986,cellular_component,cell surface;GO:0007155,biological_process,cell adhesion;GO:0009897,cellular_component,external side of plasma membrane;GO:0007160,biological_process,cell-matrix adhesion;GO:0016020,cellular_component,membrane;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0042059,biological_process,negative regulation of epidermal growth factor receptor signaling pathway;GO:0019903,molecular_function,protein phosphatase binding;GO:0034665,cellular_component,integrin alpha1-beta1 complex;GO:0030593,biological_process,neutrophil chemotaxis;GO:0098639,molecular_function,collagen binding involved in cell-matrix adhesion;GO:0016021,cellular_component,integral component of membrane;GO:0045178,cellular_component,basal part of cell;GO:0032516,biological_process,positive regulation of phosphoprotein phosphatase activity;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0005925,cellular_component,focal adhesion;GO:0045123,biological_process,cellular extravasation","K06480,ko04151,PI3K-Akt signaling pathway;K06480,ko05414,Dilated cardiomyopathy;K06480,ko04810,Regulation of actin cytoskeleton;K06480,ko04512,ECM-receptor interaction;K06480,ko04510,Focal adhesion;K06480,ko04640,Hematopoietic cell lineage;K06480,ko05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);K06480,ko05410,Hypertrophic cardiomyopathy (HCM)"]
["CD58",12.78529105,1.470166888,3.103789164,3.779150537,{"v":3.91e-11,"d":"3.91E-11"},{"v":4.89e-10,"d":"4.89E-10"},"ENSG00000116815","G3RR66,CD58 molecule","XP_004026463.1,lymphocyte function-associated antigen 3 isoform X1","-","IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold","-","GO:0009986,cellular_component,cell surface;GO:0005102,molecular_function,signaling receptor binding;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:2000484,biological_process,positive regulation of interleukin-8 secretion;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0016020,cellular_component,membrane;GO:0034113,biological_process,heterotypic cell-cell adhesion;GO:0016021,cellular_component,integral component of membrane","K06492,ko05169,Epstein-Barr virus infection;K06492,ko04514,Cell adhesion molecules (CAMs)"]
["CD274",0.809260476,0.07976228,3.213577169,1.345819613,0.016084066,0.029148747,"ENSG00000120217","H2QWZ8,CD274 molecule","XP_001140705.1,programmed cell death 1 ligand 1 isoform X2","PF08205,CD80-like C2-set immunoglobulin domain;PF07686,Immunoglobulin V-set domain","IPR007110,Immunoglobulin-like domain;IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR013106,Immunoglobulin V-set domain","ENOG410IIBU,-;ENOG4111V14,-","GO:0006955,biological_process,immune response;GO:1903556,biological_process,negative regulation of tumor necrosis factor superfamily cytokine production;GO:0070062,cellular_component,extracellular exosome;GO:0034097,biological_process,response to cytokine;GO:0009897,cellular_component,external side of plasma membrane;GO:0032693,biological_process,negative regulation of interleukin-10 production;GO:0031295,biological_process,T cell costimulation;GO:0046007,biological_process,negative regulation of activated T cell proliferation;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:1905404,biological_process,positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process;GO:0042130,biological_process,negative regulation of T cell proliferation;GO:0016020,cellular_component,membrane;GO:2001181,biological_process,positive regulation of interleukin-10 secretion;GO:0032689,biological_process,negative regulation of interferon-gamma production;GO:1901998,biological_process,toxin transport;GO:0007165,biological_process,signal transduction","K06745,ko04514,Cell adhesion molecules (CAMs)"]
["SEMA5A",0.137407706,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000112902","X5DR95,Semaphorin 5A isoform A","XP_011512458.1,-;NP_003957.2,semaphorin-5A precursor;XP_011512459.1,-;XP_006714570.1,-;XP_006714569.1,-;XP_011512457.1,-;XP_011512460.1,-","PF01403,Sema domain;PF00090,Thrombospondin type 1 domain","IPR001627,Sema domain;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR036352,Sema domain superfamily;IPR016201,PSI domain;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR027231,Semaphorin;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","KOG3611,Semaphorins;ENOG410XQZC,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K06841,ko04360,Axon guidance"]
["FUT4",0.744634884,0.054078799,3.650253927,1.670845564,0.001187534,0.002821641,"ENSG00000196371","K7AZS5,Fucosyltransferase 4","NP_001008985.2,alpha-(1,3)-fucosyltransferase 4","PF17039,ucosyltransferase, N-terminal;PF00852,lycosyltransferase family 10 (fucosyltransferase) C-term","IPR001503,Glycosyl transferase family 10;IPR038577,GT10-like superfamily;IPR031481,Fucosyltransferase, N-terminal","KOG2619,Fucosyltransferase;ENOG410ZIMX,-","GO:0009986,cellular_component,cell surface;GO:0016021,cellular_component,integral component of membrane;GO:0032580,cellular_component,Golgi cisterna membrane;GO:0006486,biological_process,protein glycosylation;GO:0005794,cellular_component,Golgi apparatus;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity;GO:0071944,cellular_component,cell periphery;GO:0008417,molecular_function,fucosyltransferase activity;GO:0016020,cellular_component,membrane;GO:0036065,biological_process,fucosylation","K07632,ko00514,Other types of O-glycan biosynthesis;K07632,ko00601,Glycosphingolipid biosynthesis - lacto and neolacto series"]
["ULBP1",7.935491806,0.52142496,3.899781951,3.844135782,{"v":4.41e-14,"d":"4.41E-14"},1.09E-12,"ENSG00000111981","H2QZY1,UL16 binding protein 1","XP_001134754.1,NKG2D ligand 1 isoform X1","PF00129,Class I Histocompatibility antigen, domains alpha 1 and 2","IPR011161,MHC class I-like antigen recognition-like;IPR037055,MHC class I-like antigen recognition-like superfamily;IPR011162,MHC classes I/II-like antigen recognition protein","ENOG41113ZC,-;ENOG410J4VC,-","GO:0030101,biological_process,natural killer cell activation;GO:0015629,cellular_component,actin cytoskeleton;GO:0042267,biological_process,natural killer cell mediated cytotoxicity;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0046658,cellular_component,anchored component of plasma membrane;GO:0005829,cellular_component,cytosol;GO:0046703,molecular_function,natural killer cell lectin-like receptor binding;GO:0016021,cellular_component,integral component of membrane","K07986,ko04650,Natural killer cell mediated cytotoxicity"]
["ATG4A",4.380884129,0.447780588,3.256826552,2.999616265,{"v":1.55E-7,"d":"1.55E-07"},{"v":8.75e-07,"d":"8.75E-07"},"ENSG00000101844","G2HGQ3,Cysteine protease","NP_001233457.1,cysteine protease ATG4A","PF03416,Peptidase family C54","IPR033474,Autophagin-2;IPR005078,Peptidase C54","KOG2674,Cysteine protease required for autophagy - Apg4p/Aut2p;ENOG410XPQ0,-","GO:0000422,biological_process,autophagy of mitochondrion;GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0000045,biological_process,autophagosome assembly;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0006914,biological_process,autophagy;GO:0006612,biological_process,protein targeting to membrane;GO:0051697,biological_process,protein delipidation;GO:0004197,molecular_function,cysteine-type endopeptidase activity;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0006501,biological_process,C-terminal protein lipidation;GO:0044804,biological_process,autophagy of nucleus;GO:0005829,cellular_component,cytosol;GO:0008233,molecular_function,peptidase activity","K08342,ko04140,Regulation of autophagy"]
["STX2",1.658330319,0.17602119,3.170078137,2.076413561,0.000206996,0.000585857,"ENSG00000111450","H2Q774,Syntaxin 2","-","PF00804,Syntaxin;PF05739,SNARE domain","IPR000727,Target SNARE coiled-coil homology domain;IPR010989,SNARE;IPR006012,Syntaxin/epimorphin, conserved site;IPR028671,Syntaxin-2;IPR006011,Syntaxin, N-terminal domain","COG5074,t-SNARE complex subunit, syntaxin;KOG0810,SNARE protein Syntaxin 1 and related proteins","GO:0000149,molecular_function,SNARE binding;GO:0031629,biological_process,synaptic vesicle fusion to presynaptic active zone membrane;GO:0005484,molecular_function,SNAP receptor activity;GO:0048278,biological_process,vesicle docking;GO:0007340,biological_process,acrosome reaction;GO:0030154,biological_process,cell differentiation;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0008021,cellular_component,synaptic vesicle;GO:0016192,biological_process,vesicle-mediated transport;GO:0031201,cellular_component,SNARE complex;GO:0016021,cellular_component,integral component of membrane;GO:0006886,biological_process,intracellular protein transport","K08486,ko04721,Synaptic vesicle cycle;K08486,ko04130,SNARE interactions in vesicular transport"]
["OLR1",1.009807618,0.10718464,3.107798762,1.270457515,0.007880255,0.015382938,"ENSG00000173391","A0A024RAU0,Oxidised low density lipoprotein","NP_002534.1,oxidized low-density lipoprotein receptor 1 isoform 1","PF08391,Ly49-like protein, N-terminal region;PF00059,Lectin C-type domain","IPR016187,C-type lectin fold;IPR013600,Ly49-like, N-terminal;IPR033992,Natural killer cell receptor-like, C-type lectin-like domain;IPR001304,C-type lectin-like;IPR016186,C-type lectin-like/link domain superfamily","KOG4297,C-type lectin;ENOG410XPJ1,-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0030246,molecular_function,carbohydrate binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005654,cellular_component,nucleoplasm","K08763,ko03320,PPAR signaling pathway;K08763,ko04145,Phagosome"]
["DAPK1",0.399899201,0.036787184,3.312126892,1.417264779,0.009611236,0.018404761,"ENSG00000196730","K7D1C4,Death-associated protein kinase 1","XP_001140455.1,-;XP_009455105.1,-;XP_520110.2,death-associated protein kinase 1 isoform X2","PF12796,Ankyrin repeats (3 copies);PF00069,Protein kinase domain;PF00531,eath domain","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR002110,Ankyrin repeat;IPR011029,Death-like domain superfamily;IPR020676,Death-associated protein kinase 1;IPR000488,Death domain;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR020859,Roc domain;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","KOG0032,Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily;ENOG410XRMJ,-","GO:0016301,molecular_function,kinase activity;GO:0006915,biological_process,apoptotic process;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0016310,biological_process,phosphorylation;GO:0007165,biological_process,signal transduction;GO:0004674,molecular_function,protein serine/threonine kinase activity","K08803,ko05219,Bladder cancer;K08803,ko05200,Pathways in cancer"]
["OTX1",1.867056801,0.203391338,3.154275395,2.553052919,{"v":6.16e-06,"d":"6.16E-06"},{"v":2.46e-05,"d":"2.46E-05"},"ENSG00000115507","G3QN56,Orthodenticle homeobox 1","XP_018876275.1,homeobox protein OTX1 isoform X2","PF03529,Otx1 transcription factor;PF00046,Homeobox domain","IPR009057,Homeobox-like domain superfamily;IPR003026,Transcription factor Otx1;IPR017970,Homeobox, conserved site;IPR013851,Transcription factor Otx, C-terminal;IPR001356,Homeobox domain;IPR003025,Transcription factor Otx","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0022037,biological_process,metencephalon development;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0007275,biological_process,multicellular organism development;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0030900,biological_process,forebrain development;GO:0030901,biological_process,midbrain development;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0048852,biological_process,diencephalon morphogenesis;GO:0005634,cellular_component,nucleus;GO:0042472,biological_process,inner ear morphogenesis","K09326,ko04550,Signaling pathways regulating pluripotency of stem cells"]
["POU5F1",0.659382562,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000204531","A0A140TAX9,POU domain protein","NP_001238970.1,-","PF00157,Pou domain - N-terminal to homeobox domain;PF00046,Homeobox domain","IPR009057,Homeobox-like domain superfamily;IPR010982,Lambda repressor-like, DNA-binding domain superfamily;IPR017970,Homeobox, conserved site;IPR015585,POU domain-containing protein, class 5;IPR013847,POU domain;IPR001356,Homeobox domain;IPR000327,POU-specific domain","-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","K09367,ko04550,Signaling pathways regulating pluripotency of stem cells"]
["FBXO32",14.3535747,1.683733727,3.08815922,5.918565729,{"v":2.15e-25,"d":"2.15E-25"},{"v":4.02e-23,"d":"4.02E-23"},"ENSG00000156804","A0A024R9F3,F-box protein 32, isoform CRA_c","NP_478136.1,F-box only protein 32 isoform 1","-","IPR036047,F-box-like domain superfamily","ENOG410YPWK,-;KOG3926,F-box proteins","GO:0014894,biological_process,response to denervation involved in regulation of muscle adaptation;GO:0071549,biological_process,cellular response to dexamethasone stimulus;GO:0005829,cellular_component,cytosol;GO:0030018,cellular_component,Z disc;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K10305,ko04068,FoxO signaling pathway"]
["AURKAPS1",1.371469486,0,5.623276026,0.572269715,0.03361661,0.055389793,"ENSG00000213033","G2HFJ0,Aurora kinase A","NP_001233545.1,aurora kinase A","PF00069,Protein kinase domain","IPR030616,Aurora kinase;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR030611,Aurora kinase A;IPR000719,Protein kinase domain","KOG0580,Serine/threonine protein kinase;ENOG410XNRB,-","GO:0019901,molecular_function,protein kinase binding;GO:0035404,biological_process,histone-serine phosphorylation;GO:0035174,molecular_function,histone serine kinase activity;GO:0097431,cellular_component,mitotic spindle pole;GO:0004672,molecular_function,protein kinase activity;GO:0046982,molecular_function,protein heterodimerization activity;GO:0000780,cellular_component,condensed nuclear chromosome, centromeric region;GO:0004712,molecular_function,protein serine/threonine/tyrosine kinase activity;GO:0005524,molecular_function,ATP binding;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0016301,molecular_function,kinase activity;GO:0007098,biological_process,centrosome cycle;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0051233,cellular_component,spindle midzone;GO:0005634,cellular_component,nucleus;GO:0007051,biological_process,spindle organization;GO:0007100,biological_process,mitotic centrosome separation;GO:0000278,biological_process,mitotic cell cycle;GO:0005813,cellular_component,centrosome;GO:0031647,biological_process,regulation of protein stability;GO:0000212,biological_process,meiotic spindle organization;GO:0016310,biological_process,phosphorylation;GO:0032133,cellular_component,chromosome passenger complex;GO:0007049,biological_process,cell cycle;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0031616,cellular_component,spindle pole centrosome;GO:0097421,biological_process,liver regeneration;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0051321,biological_process,meiotic cell cycle;GO:0032091,biological_process,negative regulation of protein binding;GO:0009611,biological_process,response to wounding;GO:0032465,biological_process,regulation of cytokinesis;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005876,cellular_component,spindle microtubule;GO:0007052,biological_process,mitotic spindle organization","K11481,ko04114,Oocyte meiosis"]
["TOMM40L",1.83694251,0.097489868,4.099822303,2.025984948,{"v":5e-05,"d":"5.00E-05"},0.000161827,"ENSG00000158882","G1RVR8,Translocase of outer mitochondrial membrane 40 like","XP_012366619.1,-","PF01459,ukaryotic porin","IPR037930,Tom40;IPR027246,Eukaryotic porin/Tom40","ENOG410XS2U,-;KOG3296,Translocase of outer mitochondrial membrane complex, subunit TOM40","GO:0030150,biological_process,protein import into mitochondrial matrix;GO:0008320,molecular_function,protein transmembrane transporter activity;GO:0032991,cellular_component,protein-containing complex;GO:0055085,biological_process,transmembrane transport;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0005739,cellular_component,mitochondrion","K11518,ko05014,Amyotrophic lateral sclerosis (ALS)"]
["SRD5A1",1.261939852,0.127412876,3.263498687,2.642025026,{"v":1.51e-06,"d":"1.51E-06"},{"v":6.89e-06,"d":"6.89E-06"},"ENSG00000145545","H2QQM0,Steroid-5-alpha-reductase, alpha polypeptide 1","XP_001144570.1,-","PF02544,3-oxo-5-alpha-steroid 4-dehydrogenase","IPR016636,3-oxo-5-alpha-steroid 4-dehydrogenase;IPR001104,3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal","ENOG410XS6P,-;KOG1638,Steroid reductase","GO:0003865,molecular_function,3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0006629,biological_process,lipid metabolic process;GO:0008202,biological_process,steroid metabolic process;GO:0006702,biological_process,androgen biosynthetic process;GO:0030540,biological_process,female genitalia development;GO:0016627,molecular_function,oxidoreductase activity, acting on the CH-CH group of donors;GO:0005737,cellular_component,cytoplasm;GO:0030539,biological_process,male genitalia development;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0042448,biological_process,progesterone metabolic process;GO:0016021,cellular_component,integral component of membrane","K12343,ko00140,Steroid hormone biosynthesis"]
["SRD5A3",2.148960591,0.148264002,3.788764302,2.577914546,{"v":5.49e-07,"d":"5.49E-07"},{"v":2.75e-06,"d":"2.75E-06"},"ENSG00000128039","H2QPH7,Steroid 5 alpha-reductase 3","XP_526623.1,-;XP_016780137.1,-","PF02544,3-oxo-5-alpha-steroid 4-dehydrogenase","IPR001104,3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal","KOG1640,Predicted steroid reductase;ENOG4111JQM,-","GO:0003865,molecular_function,3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0006629,biological_process,lipid metabolic process;GO:0016627,molecular_function,oxidoreductase activity, acting on the CH-CH group of donors;GO:0005737,cellular_component,cytoplasm;GO:0005783,cellular_component,endoplasmic reticulum;GO:0006488,biological_process,dolichol-linked oligosaccharide biosynthetic process;GO:0016628,molecular_function,oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0019348,biological_process,dolichol metabolic process;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0016095,biological_process,polyprenol catabolic process;GO:0016021,cellular_component,integral component of membrane","K12345,ko00140,Steroid hormone biosynthesis"]
["TAB3-AS2",110.5978759,5.610675429,4.272545853,4.177862629,{"v":4.71e-18,"d":"4.71E-18"},{"v":2.71e-16,"d":"2.71E-16"},"ENSG00000235512","G1RGJ6,TGF-beta activated kinase 1 and MAP3K7 binding protein 3","-","PF02845,CUE domain","IPR003892,Ubiquitin system component Cue;IPR001876,Zinc finger, RanBP2-type;IPR036443,Zinc finger, RanBP2-type superfamily","ENOG410IG4E,-;ENOG410XPAC,-","GO:0046872,molecular_function,metal ion binding","K12793,ko04621,NOD-like receptor signaling pathway;K12793,ko04668,TNF signaling pathway;K12793,ko04064,NF-kappa B signaling pathway"]
["PABPC1",3438.824667,370.9657691,3.212532457,13.14423261,{"v":4.1E-47,"d":"4.10E-47"},{"v":2e-44,"d":"2.00E-44"},"ENSG00000070756","A0A250YKH3,Polyadenylate-binding protein","XP_020036129.1,-","-","IPR036053,PABC (PABP) domain;IPR006515,Polyadenylate binding protein, human types 1, 2, 3, 4;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR002004,Polyadenylate-binding protein/Hyperplastic disc protein;IPR003954,RNA recognition motif domain, eukaryote","-","GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0003723,molecular_function,RNA binding","K13126,ko03018,RNA degradation;K13126,ko03013,RNA transport;K13126,ko03015,mRNA surveillance pathway"]
["PDE3B",0.182552431,0,5.979327299,0.806972016,0.00894141,0.017239021,"ENSG00000152270","A7E2E5,Phosphodiesterase","NP_000913.2,cGMP-inhibited 3',5'-cyclic phosphodiesterase B","PF00233,3'5'-cyclic nucleotide phosphodiesterase","IPR003607,HD/PDEase domain;IPR023174,3'5'-cyclic nucleotide phosphodiesterase, conserved site;IPR002073,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain;IPR036971,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily","ENOG410IEGG,-;ENOG410XT2V,-","GO:0016787,molecular_function,hydrolase activity;GO:0004114,molecular_function,3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0046872,molecular_function,metal ion binding;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0007165,biological_process,signal transduction","K13296,ko00230,Purine metabolism;K13296,ko04914,Progesterone-mediated oocyte maturation;K13296,ko04924,Renin secretion;K13296,ko04923,Regulation of lipolysis in adipocytes;K13296,ko04024,cAMP signaling pathway;K13296,ko04022,cGMP-PKG signaling pathway;K13296,ko05032,Morphine addiction;K13296,ko04922,Glucagon signaling pathway;K13296,ko04910,Insulin signaling pathway"]
["HSD17B6",1.149674999,0,6.264670196,1.007565613,0.002421289,0.005369716,"ENSG00000025423","A0A024RB43,Hydroxysteroid","XP_005269264.1,-;XP_005269265.1,-;XP_011537227.1,-;XP_005269266.1,-;XP_006719735.1,-;XP_011537229.1,-;NP_003716.2,17-beta-hydroxysteroid dehydrogenase type 6 precursor;XP_011537228.1,-","PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily;IPR020904,Short-chain dehydrogenase/reductase, conserved site;IPR002347,Short-chain dehydrogenase/reductase SDR","ENOG410Y7FK,-;KOG1610,Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity","K13369,ko00830,Retinol metabolism;K13369,ko00140,Steroid hormone biosynthesis"]
["GLI2",0.614595118,0.044634715,3.650253927,1.670845564,0.001187534,0.002821641,"ENSG00000074047","H2R078,GLI family zinc finger 2","XP_009441469.1,-;XP_001158280.2,zinc finger protein GLI2 isoform X1","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0021983,biological_process,pituitary gland development;GO:0009953,biological_process,dorsal/ventral pattern formation;GO:0021776,biological_process,smoothened signaling pathway involved in spinal cord motor neuron cell fate specification;GO:0021965,biological_process,spinal cord ventral commissure morphogenesis;GO:0060831,biological_process,smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0003676,molecular_function,nucleic acid binding;GO:0007224,biological_process,smoothened signaling pathway;GO:0048856,biological_process,anatomical structure development;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0030154,biological_process,cell differentiation;GO:0048646,biological_process,anatomical structure formation involved in morphogenesis;GO:0008134,molecular_function,transcription factor binding;GO:0021938,biological_process,smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation;GO:0016607,cellular_component,nuclear speck;GO:0008589,biological_process,regulation of smoothened signaling pathway;GO:0021696,biological_process,cerebellar cortex morphogenesis;GO:0005634,cellular_component,nucleus;GO:0048754,biological_process,branching morphogenesis of an epithelial tube;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0021522,biological_process,spinal cord motor neuron differentiation;GO:0021915,biological_process,neural tube development;GO:0007507,biological_process,heart development;GO:0035295,biological_process,tube development;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0021904,biological_process,dorsal/ventral neural tube patterning;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0060603,biological_process,mammary gland duct morphogenesis;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0021517,biological_process,ventral spinal cord development;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0042475,biological_process,odontogenesis of dentin-containing tooth;GO:0002009,biological_process,morphogenesis of an epithelium;GO:0021513,biological_process,spinal cord dorsal/ventral patterning;GO:0030879,biological_process,mammary gland development;GO:0009954,biological_process,proximal/distal pattern formation;GO:0001822,biological_process,kidney development;GO:0060513,biological_process,prostatic bud formation;GO:0003682,molecular_function,chromatin binding;GO:0048666,biological_process,neuron development;GO:0048566,biological_process,embryonic digestive tract development;GO:0003677,molecular_function,DNA binding;GO:0090103,biological_process,cochlea morphogenesis;GO:0021775,biological_process,smoothened signaling pathway involved in ventral spinal cord interneuron specification;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0007411,biological_process,axon guidance;GO:0097542,cellular_component,ciliary tip;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0002062,biological_process,chondrocyte differentiation;GO:0030902,biological_process,hindbrain development;GO:0042733,biological_process,embryonic digit morphogenesis;GO:0016020,cellular_component,membrane;GO:0021508,biological_process,floor plate formation;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0007389,biological_process,pattern specification process;GO:0008270,molecular_function,zinc ion binding;GO:0005930,cellular_component,axoneme;GO:0030324,biological_process,lung development;GO:0060322,biological_process,head development;GO:0060032,biological_process,notochord regression;GO:0005730,cellular_component,nucleolus;GO:0008283,biological_process,cell proliferation;GO:0002076,biological_process,osteoblast development;GO:0001501,biological_process,skeletal system development;GO:0005929,cellular_component,cilium;GO:0032331,biological_process,negative regulation of chondrocyte differentiation;GO:0031514,cellular_component,motile cilium;GO:0001701,biological_process,in utero embryonic development;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0045740,biological_process,positive regulation of DNA replication;GO:0007418,biological_process,ventral midline development;GO:0007442,biological_process,hindgut morphogenesis;GO:0048589,biological_process,developmental growth;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0001649,biological_process,osteoblast differentiation","K16798,ko04340,Hedgehog signaling pathway;K16798,ko05217,Basal cell carcinoma;K16798,ko04390,Hippo signaling pathway;K16798,ko05200,Pathways in cancer"]
["EOGT",1.135770403,0.116089795,3.224229648,2.118968855,1.26105E-4,0.000373122,"ENSG00000163378","A0A0D9RGY5,EGF domain specific O-linked N-acetylglucosamine transferase","XP_007983122.1,-;XP_007983123.1,-;XP_007983120.1,EGF domain-specific O-linked N-acetylglucosamine transferase;XP_007983121.1,-","PF04577,Protein of unknown function (DUF563)","IPR007657,Glycosyltransferase 61","-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016262,molecular_function,protein N-acetylglucosaminyltransferase activity;GO:0006493,biological_process,protein O-linked glycosylation","K18134,ko00514,Other types of O-glycan biosynthesis"]
["DLX5",6.014821622,0.691637879,3.087384252,2.859478701,{"v":1.33E-6,"d":"1.33E-06"},{"v":6.15e-06,"d":"6.15E-06"},"ENSG00000105880","G3QP29,Distal-less homeobox 5","XP_004045842.1,-","PF12413,Homeobox protein distal-less-like N terminal;PF00046,Homeobox domain","IPR009057,Homeobox-like domain superfamily;IPR000047,Helix-turn-helix motif;IPR017970,Homeobox, conserved site;IPR020479,Homeobox domain, metazoa;IPR001356,Homeobox domain;IPR022135,Distal-less-like homeobox protein, N-terminal domain","-","GO:0007409,biological_process,axonogenesis;GO:0030855,biological_process,epithelial cell differentiation;GO:0060325,biological_process,face morphogenesis;GO:0048646,biological_process,anatomical structure formation involved in morphogenesis;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0001649,biological_process,osteoblast differentiation;GO:0097376,biological_process,interneuron axon guidance;GO:0071773,biological_process,cellular response to BMP stimulus;GO:0010628,biological_process,positive regulation of gene expression;GO:0005634,cellular_component,nucleus;GO:0042472,biological_process,inner ear morphogenesis;GO:0060021,biological_process,roof of mouth development;GO:0005737,cellular_component,cytoplasm;GO:0021889,biological_process,olfactory bulb interneuron differentiation;GO:0071837,molecular_function,HMG box domain binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0030509,biological_process,BMP signaling pathway;GO:0000790,cellular_component,nuclear chromatin;GO:0001958,biological_process,endochondral ossification;GO:0060166,biological_process,olfactory pit development;GO:0003677,molecular_function,DNA binding;GO:1901522,biological_process,positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0007411,biological_process,axon guidance;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0050679,biological_process,positive regulation of epithelial cell proliferation;GO:0060349,biological_process,bone morphogenesis;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0060322,biological_process,head development;GO:0008283,biological_process,cell proliferation;GO:0043583,biological_process,ear development;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway","K18489,ko04550,Signaling pathways regulating pluripotency of stem cells"]
["CH507-42P11.8",0.395272818,0,5.8122579,0.694588199,0.017297867,0.030736627,"ENSG00000275993","A0A0B4J2F2,SNF1-like kinase, isoform CRA_a","NP_001307572.1,serine/threonine-protein kinase SIK1","PF00069,Protein kinase domain","IPR015940,Ubiquitin-associated domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR017090,Serine/threonine-protein kinase, SIK1/2;IPR034672,Salt-Inducible kinase, catalytic domain;IPR000719,Protein kinase domain","KOG0586,Serine/threonine protein kinase;ENOG410XNQ0,-","GO:0016301,molecular_function,kinase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0032870,biological_process,cellular response to hormone stimulus;GO:0000287,molecular_function,magnesium ion binding;GO:0016310,biological_process,phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0004674,molecular_function,protein serine/threonine kinase activity","K19008,ko04922,Glucagon signaling pathway"]
["COL5A1",0.318339635,0,6.707116794,1.338042713,0.000352487,0.000943384,"ENSG00000130635","A0A024R8E5,Collagen, type V, alpha 1, isoform CRA_a","NP_000084.3,collagen alpha-1(V) chain isoform 1 preproprotein","PF01391,Collagen triple helix repeat (20 copies);PF01410,ibrillar collagen C-terminal domain","IPR008160,Collagen triple helix repeat;IPR001791,Laminin G domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000885,Fibrillar collagen, C-terminal","ENOG410XNMM,-;KOG3544,Collagens (type IV and type XIII), and related proteins","GO:0003007,biological_process,heart morphogenesis;GO:0005578,,;GO:0005581,cellular_component,collagen trimer;GO:0005615,cellular_component,extracellular space;GO:0005604,cellular_component,basement membrane;GO:0030199,biological_process,collagen fibril organization;GO:0005201,molecular_function,extracellular matrix structural constituent;GO:0001568,biological_process,blood vessel development;GO:0051128,biological_process,regulation of cellular component organization;GO:0043588,biological_process,skin development;GO:0035989,biological_process,tendon development","K19721,ko04974,Protein digestion and absorption"]
["MYPN",1.513556167,0.185645011,2.994564391,2.783698337,{"v":4.85e-06,"d":"4.85E-06"},{"v":1.98E-5,"d":"1.98E-05"},"ENSG00000138347","H2R4C7,Uncharacterized protein","XP_016773899.1,-;XP_016773900.1,-;XP_009456834.1,myopalladin isoform X3","PF07679,Immunoglobulin I-set domain","IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","ENOG41103YT,-;ENOG410IGH0,-","GO:0030334,biological_process,regulation of cell migration;GO:0045214,biological_process,sarcomere organization;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0031674,cellular_component,I band;GO:0017124,molecular_function,SH3 domain binding;GO:0051493,biological_process,regulation of cytoskeleton organization;GO:0048739,biological_process,cardiac muscle fiber development;GO:0051015,molecular_function,actin filament binding;GO:0030018,cellular_component,Z disc;GO:0051371,molecular_function,muscle alpha-actinin binding","-"]
["PAX9",1.770622459,0.21717544,2.994564391,2.783698337,{"v":4.85e-06,"d":"4.85E-06"},{"v":1.98E-5,"d":"1.98E-05"},"ENSG00000198807","G3QGP5,Paired box 9","XP_004055141.1,-","PF00292,'Paired box' domain","IPR001523,Paired domain;IPR009057,Homeobox-like domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR033204,Paired box protein PAX9","-","GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0007275,biological_process,multicellular organism development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0009887,biological_process,animal organ morphogenesis;GO:0005634,cellular_component,nucleus","-"]
["PTCD2",0.882022826,0.108184381,2.994564391,2.783698337,{"v":4.85e-06,"d":"4.85E-06"},{"v":1.98E-5,"d":"1.98E-05"},"ENSG00000049883","A0A024RAM6,Pentatricopeptide repeat domain 2, isoform CRA_a","NP_079030.3,pentatricopeptide repeat-containing protein 2, mitochondrial isoform 1","PF10037,Mitochondrial 28S ribosomal protein S27","IPR034629,Pentatricopeptide repeat-containing protein 2, mitochondrial;IPR034913,MRPS27/PTCD2;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR002885,Pentatricopeptide repeat","ENOG410IIEH,-;ENOG4111GFQ,-","GO:0007507,biological_process,heart development;GO:0007005,biological_process,mitochondrion organization;GO:0048747,biological_process,muscle fiber development;GO:0055010,biological_process,ventricular cardiac muscle tissue morphogenesis;GO:0050684,biological_process,regulation of mRNA processing;GO:0005739,cellular_component,mitochondrion;GO:0010468,biological_process,regulation of gene expression;GO:0001822,biological_process,kidney development;GO:0001889,biological_process,liver development","-"]
["RP11-264B14.1",18.81968517,2.291352763,2.994455554,2.424713833,{"v":2.53e-05,"d":"2.53E-05"},{"v":8.79e-05,"d":"8.79E-05"},"ENSG00000267207","G8F6G9,Uncharacterized protein","-","PF00276,Ribosomal protein L23;PF03939,Ribosomal protein L23, N-terminal domain","IPR012678,Ribosomal protein L23/L15e core domain superfamily;IPR005633,Ribosomal protein L23/L25, N-terminal;IPR019985,Ribosomal protein L23;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR013025,Ribosomal protein L25/L23;IPR001014,Ribosomal protein L23/L25, conserved site","-","GO:0005840,cellular_component,ribosome;GO:0003735,molecular_function,structural constituent of ribosome;GO:0006412,biological_process,translation;GO:0030529,,;GO:0005622,cellular_component,intracellular","-"]
["ZNF329",1.873670211,0.228124933,2.994455554,2.424713833,{"v":2.53e-05,"d":"2.53E-05"},{"v":8.79e-05,"d":"8.79E-05"},"ENSG00000181894","A0A024R4Q4,Zinc finger protein 329, isoform CRA_a","XP_016882796.1,-;XP_011525618.1,-;XP_006723446.1,-;XP_016882797.1,-;XP_006723445.1,-;XP_016882798.1,-;XP_016882800.1,-;XP_006723444.1,-;XP_016882799.1,-;NP_078896.3,zinc finger protein 329;XP_006723447.1,-;XP_011525617.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["HHEX",2.163003304,0.259535402,2.994243287,1.940213124,0.000910749,2.210662E-3,"ENSG00000152804","H2Q2A0,Hematopoietically expressed homeobox","XP_507925.2,-","PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR020479,Homeobox domain, metazoa;IPR009057,Homeobox-like domain superfamily","KOG0483,Transcription factor HEX, contains HOX and HALZ domains;ENOG410Z2UE,-","GO:0034504,biological_process,protein localization to nucleus;GO:0001570,biological_process,vasculogenesis;GO:0035264,biological_process,multicellular organism growth;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0070491,molecular_function,repressing transcription factor binding;GO:0030900,biological_process,forebrain development;GO:0009887,biological_process,animal organ morphogenesis;GO:0030878,biological_process,thyroid gland development;GO:0005634,cellular_component,nucleus;GO:0035050,biological_process,embryonic heart tube development;GO:0008134,molecular_function,transcription factor binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0071837,molecular_function,HMG box domain binding;GO:0022027,biological_process,interkinetic nuclear migration;GO:0030177,biological_process,positive regulation of Wnt signaling pathway;GO:0048729,biological_process,tissue morphogenesis;GO:0061009,biological_process,common bile duct development;GO:0070365,biological_process,hepatocyte differentiation;GO:0008301,molecular_function,DNA binding, bending;GO:0031016,biological_process,pancreas development;GO:0003682,molecular_function,chromatin binding;GO:0071103,biological_process,DNA conformation change;GO:0042127,biological_process,regulation of cell proliferation;GO:0007165,biological_process,signal transduction;GO:0030097,biological_process,hemopoiesis;GO:0003677,molecular_function,DNA binding;GO:0002573,biological_process,myeloid leukocyte differentiation;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0048853,biological_process,forebrain morphogenesis;GO:0008190,molecular_function,eukaryotic initiation factor 4E binding;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0061010,biological_process,gall bladder development;GO:0016973,biological_process,poly(A)+ mRNA export from nucleus;GO:0007492,biological_process,endoderm development;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0061017,biological_process,hepatoblast differentiation;GO:0002009,biological_process,morphogenesis of an epithelium;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0030154,biological_process,cell differentiation;GO:0032993,cellular_component,protein-DNA complex;GO:0061011,biological_process,hepatic duct development;GO:0030183,biological_process,B cell differentiation;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001889,biological_process,liver development;GO:0045736,biological_process,negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0090009,biological_process,primitive streak formation;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001701,biological_process,in utero embryonic development;GO:0007219,biological_process,Notch signaling pathway;GO:0048568,biological_process,embryonic organ development;GO:0008283,biological_process,cell proliferation;GO:0030948,biological_process,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0006406,biological_process,mRNA export from nucleus;GO:0060431,biological_process,primary lung bud formation","K08024,ko05202,Transcriptional misregulation in cancer;K08024,ko04950,Maturity onset diabetes of the young"]
["ZIC2",1.650025179,0.197983955,2.994243287,1.940213124,0.000910749,2.210662E-3,"ENSG00000043355","G1R8G5,Zic family member 2","XP_003270194.1,zinc finger protein ZIC 2","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus","-"]
["RP11-817O13.8",3.81928905,0.458270553,2.994243287,1.940213124,0.000910749,2.210662E-3,"ENSG00000260274","T0NKL7,Uncharacterized protein","-","PF01074,lycosyl hydrolases family 38 N-terminal domain;PF08295,Sin3 family co-repressor;PF07748,lycosyl hydrolases family 38 C-terminal domain;PF16879,C-terminal domain of Sin3a protein;PF02671,Paired amphipathic helix repeat;PF09261,Alpha mannosidase middle domain","IPR037969,Paired amphipathic helix protein Sin3a;IPR011013,Galactose mutarotase-like domain superfamily;IPR000602,Glycoside hydrolase family 38, N-terminal domain;IPR037094,Glycoside hydrolase family 38, central domain superfamily;IPR031693,Sin3, C-terminal;IPR013194,Histone deacetylase interacting domain;IPR011330,Glycoside hydrolase/deacetylase, beta/alpha-barrel;IPR015341,Glycoside hydrolase family 38, central domain;IPR011682,Glycosyl hydrolase family 38, C-terminal;IPR036600,Paired amphipathic helix superfamily;IPR003822,Paired amphipathic helix;IPR028995,Glycoside hydrolase families 57/38, central domain superfamily;IPR027291,Glycoside hydrolase 38, N-terminal domain superfamily","-","GO:0016580,cellular_component,Sin3 complex;GO:0005975,biological_process,carbohydrate metabolic process;GO:0006013,biological_process,mannose metabolic process;GO:0003824,molecular_function,catalytic activity;GO:1903507,biological_process,negative regulation of nucleic acid-templated transcription;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030246,molecular_function,carbohydrate binding;GO:0003714,molecular_function,transcription corepressor activity;GO:0004559,molecular_function,alpha-mannosidase activity;GO:0005634,cellular_component,nucleus","-"]
["GOLGA2P7",1.111207191,0.133332022,2.994243287,1.940213124,0.000910749,2.210662E-3,"ENSG00000225151","G1M9Z8,Dynamin 1","-","PF00350,ynamin family;PF01031,ynamin central region;PF02212,ynamin GTPase effector domain;PF00169,PH domain","IPR019762,Dynamin, GTPase region, conserved site;IPR000375,Dynamin central domain;IPR020850,GTPase effector domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR027741,Dynamin-1;IPR030381,Dynamin-type guanine nucleotide-binding (G) domain;IPR011993,PH-like domain superfamily;IPR022812,Dynamin superfamily;IPR003130,Dynamin GTPase effector;IPR001849,Pleckstrin homology domain;IPR001401,Dynamin, GTPase domain","KOG0446,Vacuolar sorting protein VPS1, dynamin, and related proteins;COG0699,Predicted GTPases (dynamin-related)","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0005525,molecular_function,GTP binding;GO:0042802,molecular_function,identical protein binding;GO:0007032,biological_process,endosome organization;GO:0005634,cellular_component,nucleus;GO:0072583,biological_process,clathrin-dependent endocytosis;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0006897,biological_process,endocytosis;GO:0005654,cellular_component,nucleoplasm","-"]
["ARL17B",1.29452082,0.15532754,2.994243287,1.940213124,0.000910749,2.210662E-3,"ENSG00000228696","I3L3L1,ADP-ribosylation factor-like protein 17","XP_011544691.1,-;XP_011522466.1,ADP-ribosylation factor-like protein 17 isoform X3;XP_011523179.1,-","PF15840,ADP-ribosylation factor-like protein 17;PF00025,ADP-ribosylation factor family","IPR031687,ADP-ribosylation factor-like protein 17, C-terminal;IPR006689,Small GTPase superfamily, ARF/SAR type;IPR024156,Small GTPase superfamily, ARF type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1100,GTPase SAR1 and related small G proteins;KOG0070,GTP-binding ADP-ribosylation factor Arf1","GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular","-"]
["RP5-1033H22.2",1.458301813,0.167688559,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000224093","A0A1A6HVM9,Uncharacterized protein","-","PF00017,SH2 domain","IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR028849,Breast cancer anti-estrogen resistance protein 3;IPR036860,SH2 domain superfamily;IPR000980,SH2 domain;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily","-","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0007165,biological_process,signal transduction;GO:0005622,cellular_component,intracellular","-"]
["RP11-383C5.8",5.043401316,0.579935301,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000280561","Q8N9J6,cDNA FLJ37035 fis, clone BRACE2011545","-","-","-","-","-","-"]
["PABPC1P4",1.51974493,0.174753837,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000255642","A0A1S3ABN7,Polyadenylate-binding protein","XP_007532497.1,polyadenylate-binding protein 1 isoform X2","-","IPR036053,PABC (PABP) domain;IPR006515,Polyadenylate binding protein, human types 1, 2, 3, 4;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR002004,Polyadenylate-binding protein/Hyperplastic disc protein;IPR003954,RNA recognition motif domain, eukaryote","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005737,cellular_component,cytoplasm","-"]
["RP11-864J10.4",1.6624981,0.191168871,2.993646678,1.19072542,0.007880255,0.015382938,"-","-","-","-","-","-","-","-"]
["RP11-638I2.6",4.111863988,0.472818824,2.993646678,1.19072542,0.007880255,0.015382938,"-","-","-","-","-","-","-","-"]
["BEAN1",0.386166383,0.044404858,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000166546","H2NR36,Brain expressed associated with NEDD4 1","XP_002826561.2,protein BEAN1 isoform X1","-","-","ENOG4111GT8,-;ENOG410IWAK,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["DLX4",0.781976329,0.089918618,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000108813","H2NVL7,Distal-less homeobox 4","XP_002834328.1,-","PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR020479,Homeobox domain, metazoa;IPR009057,Homeobox-like domain superfamily;IPR000047,Helix-turn-helix motif","KOG0850,Transcription factor DLX and related proteins with LIM Zn-binding and HOX domains;ENOG410ZHZR,-","GO:0003677,molecular_function,DNA binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["DNAAF3",0.862968426,0.099231813,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000167646","A0A0C4DH81,Dynein assembly factor 3, axonemal","NP_001243643.1,dynein assembly factor 3, axonemal isoform 1","PF14740,omain of unknown function (DUF4471);PF14737,omain of unknown function (DUF4470)","IPR028235,Dynein assembly factor 3, C-terminal domain;IPR027974,Domain of unknown function DUF4470","ENOG410XP2W,-;ENOG410IENI,-","-","-"]
["PIGZ",0.887425021,0.10204405,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000119227","G3QUW4,Mannosyltransferase","XP_004038318.1,GPI mannosyltransferase 4 isoform X2;XP_018880317.1,-","PF03901,Alg9-like mannosyltransferase family","IPR005599,GPI mannosyltransferase","-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0006506,biological_process,GPI anchor biosynthetic process;GO:0097502,biological_process,mannosylation;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0000026,molecular_function,alpha-1,2-mannosyltransferase activity;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane;GO:0000030,molecular_function,mannosyltransferase activity","K08098,ko00563,Glycosylphosphatidylinositol(GPI)-anchor biosynthesis"]
["STX11",1.479502463,0.170126399,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000135604","H2PKI6,Syntaxin 11","XP_002817498.1,syntaxin-11","PF00804,Syntaxin","IPR000727,Target SNARE coiled-coil homology domain;IPR010989,SNARE;IPR006012,Syntaxin/epimorphin, conserved site;IPR028672,Syntaxin-11;IPR006011,Syntaxin, N-terminal domain","COG5074,t-SNARE complex subunit, syntaxin;KOG0810,SNARE protein Syntaxin 1 and related proteins","GO:0005794,cellular_component,Golgi apparatus;GO:0005484,molecular_function,SNAP receptor activity;GO:0061025,biological_process,membrane fusion;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0006886,biological_process,intracellular protein transport","K08487,ko04130,SNARE interactions in vesicular transport"]
["DLL1",0.883298743,0.101569574,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000198719","H2QU26,Delta-like protein","XP_520601.2,-","PF07657,N terminus of Notch ligand;PF00008,-like domain;PF01414,elta serrate ligand;PF12661,Human growth factor-like EGF","IPR018097,EGF-like calcium-binding, conserved site;IPR001774,Delta/Serrate/lag-2 (DSL) protein;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011651,Notch ligand, N-terminal domain;IPR001881,EGF-like calcium-binding domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site","ENOG410XUNS,-;ENOG410IR7B,-","GO:0001757,biological_process,somite specification;GO:0003323,biological_process,type B pancreatic cell development;GO:0051302,biological_process,regulation of cell division;GO:0045665,biological_process,negative regulation of neuron differentiation;GO:0005912,cellular_component,adherens junction;GO:0030857,biological_process,negative regulation of epithelial cell differentiation;GO:0048631,biological_process,regulation of skeletal muscle tissue growth;GO:0034351,biological_process,negative regulation of glial cell apoptotic process;GO:0005509,molecular_function,calcium ion binding;GO:1900746,biological_process,regulation of vascular endothelial growth factor signaling pathway;GO:0007267,biological_process,cell-cell signaling;GO:0021693,biological_process,cerebellar Purkinje cell layer structural organization;GO:0005886,cellular_component,plasma membrane;GO:0030957,molecular_function,Tat protein binding;GO:0097110,molecular_function,scaffold protein binding;GO:0010628,biological_process,positive regulation of gene expression;GO:0005112,molecular_function,Notch binding;GO:0021688,biological_process,cerebellar molecular layer formation;GO:0040008,biological_process,regulation of growth;GO:0050767,biological_process,regulation of neurogenesis;GO:0045747,biological_process,positive regulation of Notch signaling pathway;GO:0008217,biological_process,regulation of blood pressure;GO:0060041,biological_process,retina development in camera-type eye;GO:2000505,-,-;GO:0048630,biological_process,skeletal muscle tissue growth;GO:0045807,biological_process,positive regulation of endocytosis;GO:0060042,biological_process,retina morphogenesis in camera-type eye;GO:0021510,biological_process,spinal cord development;GO:0035265,biological_process,organ growth;GO:0048839,biological_process,inner ear development;GO:0016021,cellular_component,integral component of membrane;GO:0060853,biological_process,Notch signaling pathway involved in arterial endothelial cell fate commitment;GO:0045608,biological_process,negative regulation of inner ear auditory receptor cell differentiation;GO:0046331,biological_process,lateral inhibition;GO:0098773,biological_process,skin epidermis development;GO:0072006,biological_process,nephron development;GO:0001947,biological_process,heart looping;GO:0014807,biological_process,regulation of somitogenesis;GO:0014002,biological_process,astrocyte development;GO:0030155,biological_process,regulation of cell adhesion;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0007275,biological_process,multicellular organism development;GO:0007154,biological_process,cell communication;GO:0016324,cellular_component,apical plasma membrane;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0097150,biological_process,neuronal stem cell population maintenance;GO:0070986,biological_process,left/right axis specification;GO:0016020,cellular_component,membrane;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0007386,biological_process,compartment pattern specification;GO:0072070,biological_process,loop of Henle development;GO:0048633,biological_process,positive regulation of skeletal muscle tissue growth;GO:0045662,biological_process,negative regulation of myoblast differentiation;GO:0045121,cellular_component,membrane raft;GO:0045638,biological_process,negative regulation of myeloid cell differentiation;GO:0007368,biological_process,determination of left/right symmetry;GO:0001756,biological_process,somitogenesis;GO:2000726,biological_process,negative regulation of cardiac muscle cell differentiation;GO:0002315,biological_process,marginal zone B cell differentiation;GO:0032693,biological_process,negative regulation of interleukin-10 production;GO:0045605,biological_process,negative regulation of epidermal cell differentiation;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0009954,biological_process,proximal/distal pattern formation;GO:0072014,biological_process,proximal tubule development;GO:1903672,biological_process,positive regulation of sprouting angiogenesis;GO:0097102,biological_process,endothelial tip cell fate specification;GO:0007219,biological_process,Notch signaling pathway;GO:0048665,biological_process,neuron fate specification;GO:0045596,biological_process,negative regulation of cell differentiation","-"]
["RP11-216B9.6",2.294300921,0.263819199,2.993646678,1.19072542,0.007880255,0.015382938,"ENSG00000228395","I7GC03,Macaca fascicularis brain cDNA clone: QflA-17923, similar to human protocadherin 11 X-linked","-","-","-","-","-","-"]
["ARID2",8.98773041,1.134811964,2.982355238,5.967131437,{"v":1.78e-24,"d":"1.78E-24"},{"v":3.01e-22,"d":"3.01E-22"},"ENSG00000189079","G3RDG4,AT-rich interaction domain 2","XP_004053045.1,AT-rich interactive domain-containing protein 2 isoform X1","PF01388,ARID/BRIGHT DNA binding domain;PF02257,RFX DNA-binding domain","IPR013087,Zinc finger C2H2-type;IPR001606,ARID DNA-binding domain;IPR003150,DNA-binding RFX-type winged-helix domain;IPR036431,ARID DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR016024,Armadillo-type fold;IPR036390,Winged helix DNA-binding domain superfamily","-","GO:0060038,biological_process,cardiac muscle cell proliferation;GO:0006337,biological_process,nucleosome disassembly;GO:0003677,molecular_function,DNA binding;GO:0072358,biological_process,cardiovascular system development;GO:0003676,molecular_function,nucleic acid binding;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0003007,biological_process,heart morphogenesis;GO:0048568,biological_process,embryonic organ development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0042592,biological_process,homeostatic process;GO:0060982,biological_process,coronary artery morphogenesis;GO:0005886,cellular_component,plasma membrane;GO:0005634,cellular_component,nucleus;GO:0030336,biological_process,negative regulation of cell migration;GO:0005654,cellular_component,nucleoplasm","-"]
["MUC20",25.03698402,3.161732466,2.982048631,5.93279284,{"v":3.81e-24,"d":"3.81E-24"},{"v":6.07e-22,"d":"6.07E-22"},"ENSG00000176945","C9JJE7,Mucin-20","-","-","IPR034551,Mucin-20","ENOG4111Y2D,-;ENOG410IVUU,-","GO:0048012,biological_process,hepatocyte growth factor receptor signaling pathway","-"]
["LAMTOR3",4.326651961,0.542745886,2.976126146,3.493911935,{"v":5.93E-9,"d":"5.93E-09"},{"v":4.59e-08,"d":"4.59E-08"},"ENSG00000109270","A0A212CLI2,LAMTOR3","-","-","IPR015019,Ragulator complex protein LAMTOR3","-","GO:0032006,biological_process,regulation of TOR signaling","-"]
["PANX1",5.659938457,0.709996631,2.973027209,3.288466934,{"v":1.93e-08,"d":"1.93E-08"},{"v":1.33e-07,"d":"1.33E-07"},"ENSG00000110218","A0A024R397,Pannexin","NP_056183.2,pannexin-1","PF00876,Innexin","IPR000990,Innexin","ENOG410YA5H,-;ENOG410II5X,-","GO:0002931,biological_process,response to ischemia;GO:0030054,cellular_component,cell junction;GO:0050718,biological_process,positive regulation of interleukin-1 beta secretion;GO:0033198,biological_process,response to ATP;GO:0005921,cellular_component,gap junction;GO:0005243,molecular_function,gap junction channel activity;GO:0055085,biological_process,transmembrane transport;GO:0044325,molecular_function,ion channel binding;GO:0002020,molecular_function,protease binding;GO:0007267,biological_process,cell-cell signaling;GO:0015267,molecular_function,channel activity;GO:0006811,biological_process,ion transport;GO:0005886,cellular_component,plasma membrane;GO:0003779,molecular_function,actin binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0016020,cellular_component,membrane;GO:0097110,molecular_function,scaffold protein binding;GO:0050717,biological_process,positive regulation of interleukin-1 alpha secretion;GO:0051015,molecular_function,actin filament binding;GO:0016021,cellular_component,integral component of membrane;GO:0050715,biological_process,positive regulation of cytokine secretion","-"]
["NECTIN3",2.534341783,0.31791408,2.973027209,3.288466934,{"v":1.93e-08,"d":"1.93E-08"},{"v":1.33e-07,"d":"1.33E-07"},"ENSG00000177707","K7DHM1,Poliovirus receptor-related 3","-","PF08205,CD80-like C2-set immunoglobulin domain;PF07686,Immunoglobulin V-set domain","IPR007110,Immunoglobulin-like domain;IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR013106,Immunoglobulin V-set domain;IPR033319,Nectin-3","ENOG410ZRVN,-;ENOG410IGR7,-","GO:0007286,biological_process,spermatid development;GO:0005911,cellular_component,cell-cell junction;GO:0050839,molecular_function,cell adhesion molecule binding;GO:0007155,biological_process,cell adhesion;GO:0042803,molecular_function,protein homodimerization activity;GO:0046982,molecular_function,protein heterodimerization activity;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["SAMD10",4.259374803,0.534306474,2.962248187,2.757485116,{"v":7.46e-06,"d":"7.46E-06"},{"v":2.92e-05,"d":"2.92E-05"},"ENSG00000130590","H2QKT8,Uncharacterized protein","NP_001238837.1,-","PF07647,SAM domain (Sterile alpha motif)","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","ENOG41128Z9,-;ENOG410IJ7W,-","-","-"]
["RUNX1",0.670877513,0.084156529,2.962248187,2.757485116,{"v":7.46e-06,"d":"7.46E-06"},{"v":2.92e-05,"d":"2.92E-05"},"ENSG00000159216","H2RAI7,Runt-related transcription factor","-","PF00853,Runt domain;PF08504,Runx inhibition domain","IPR013524,Runt domain;IPR013711,Runx, C-terminal  domain;IPR012346,p53/RUNT-type transcription factor, DNA-binding domain superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR027384,Runx, central domain superfamily;IPR016554,Runt-related transcription factor RUNX;IPR000040,Acute myeloid leukemia 1 protein (AML1)/Runt","ENOG4111J4Y,-;KOG3982,Runt and related transcription factors","GO:0030097,biological_process,hemopoiesis;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045595,biological_process,regulation of cell differentiation;GO:0005524,molecular_function,ATP binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0002062,biological_process,chondrocyte differentiation;GO:0006351,biological_process,transcription, DNA-templated;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0001503,biological_process,ossification;GO:0005634,cellular_component,nucleus;GO:0030182,biological_process,neuron differentiation","K08367,ko05200,Pathways in cancer;K08367,ko05220,Chronic myeloid leukemia;K08367,ko05202,Transcriptional misregulation in cancer;K08367,ko05221,Acute myeloid leukemia"]
["COBL",0.728151536,0.091341123,2.962248187,2.757485116,{"v":7.46e-06,"d":"7.46E-06"},{"v":2.92e-05,"d":"2.92E-05"},"ENSG00000106078","H2QUK9,Uncharacterized protein","XP_519099.3,protein cordon-bleu isoform X9","PF02205,WH2 motif;PF09469,Cordon-bleu ubiquitin-like domain","IPR003124,WH2 domain;IPR019025,Cordon-bleu, ubiquitin-like domain","ENOG410IJC4,-;ENOG410YD9K,-","GO:0051639,biological_process,actin filament network formation;GO:0003785,molecular_function,actin monomer binding;GO:0030041,biological_process,actin filament polymerization;GO:0003779,molecular_function,actin binding","-"]
["PABPC3",18.85939743,2.418537386,2.95780465,5.216119368,{"v":2.76e-19,"d":"2.76E-19"},{"v":2e-17,"d":"2.00E-17"},"ENSG00000151846","Q5VX58,Polyadenylate-binding protein","NP_112241.2,polyadenylate-binding protein 3","PF00658,Poly-adenylate binding protein, unique domain;PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR036053,PABC (PABP) domain;IPR006515,Polyadenylate binding protein, human types 1, 2, 3, 4;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR002004,Polyadenylate-binding protein/Hyperplastic disc protein;IPR003954,RNA recognition motif domain, eukaryote","ENOG410XR5X,-;KOG0123,Polyadenylate-binding protein (RRM superfamily)","GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0003723,molecular_function,RNA binding;GO:0005829,cellular_component,cytosol","K13126,ko03018,RNA degradation;K13126,ko03013,RNA transport;K13126,ko03015,mRNA surveillance pathway"]
["ZNF248",1.082495482,0.135790901,2.951572412,2.390667793,{"v":4.05e-05,"d":"4.05E-05"},1.3432E-4,"ENSG00000198105","A2RUI7,Zinc finger protein 248","XP_011517899.1,-;NP_001254526.1,-;XP_016871934.1,-;NP_066383.1,zinc finger protein 248 isoform 1;XP_016871935.1,-;XP_006717548.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["MIR1260B",88.04702016,11.04483523,2.951572412,2.390667793,{"v":4.05e-05,"d":"4.05E-05"},1.3432E-4,"-","-","-","-","-","-","-","-"]
["RP3-430N8.10",77.35444127,9.929195305,2.945344311,3.64548307,9.58E-10,{"v":8.84e-09,"d":"8.84E-09"},"-","-","-","-","-","-","-","-"]
["IRF2BP1",6.945987089,0.894556987,2.938230581,3.462314122,{"v":1.25e-08,"d":"1.25E-08"},{"v":9.02E-8,"d":"9.02E-08"},"ENSG00000170604","H2QGM3,Interferon regulatory factor 2 binding protein 1","XP_003316501.1,-","PF11261,Interferon regulatory factor 2-binding protein zinc finger;PF00097,Zinc finger, C3HC4 type (RING finger)","IPR022750,Interferon regulatory factor 2-binding protein 1 & 2, zinc finger;IPR018957,Zinc finger, C3HC4 RING-type","ENOG410Z1AW,-;KOG3579,Predicted E3 ubiquitin ligase","GO:0046872,molecular_function,metal ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["SPATA2",5.338682423,0.690625528,2.935943269,3.795097666,{"v":1.2E-10,"d":"1.20E-10"},{"v":1.35e-09,"d":"1.35E-09"},"ENSG00000158480","H2QKJ9,Spermatogenesis associated 2","XP_009435686.1,-;XP_003317053.1,-;XP_001167299.1,spermatogenesis-associated protein 2","-","IPR029744,Spermatogenesis-associated protein 2","ENOG410XZJ4,-;ENOG410IGAI,-","GO:0005737,cellular_component,cytoplasm;GO:0005634,cellular_component,nucleus;GO:0001650,cellular_component,fibrillar center","-"]
["PLPP3",0.98829421,0.123974062,2.930523587,1.891634689,0.001488068,0.003456622,"ENSG00000162407","G3QDI5,Uncharacterized protein","XP_004025914.1,-","PF01569,PAP2 superfamily","IPR028675,Lipid phosphate phosphohydrolase 3;IPR036938,Phosphatidic acid phosphatase type 2/haloperoxidase superfamily;IPR000326,Phosphatidic acid phosphatase type 2/haloperoxidase","-","GO:0006644,biological_process,phospholipid metabolic process;GO:0050821,biological_process,protein stabilization;GO:0007155,biological_process,cell adhesion;GO:0098609,biological_process,cell-cell adhesion;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0042392,molecular_function,sphingosine-1-phosphate phosphatase activity;GO:0060020,biological_process,Bergmann glial cell differentiation;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0005178,molecular_function,integrin binding;GO:1902068,biological_process,regulation of sphingolipid mediated signaling pathway;GO:0016311,biological_process,dephosphorylation;GO:0016020,cellular_component,membrane;GO:0051091,biological_process,positive regulation of DNA binding transcription factor activity;GO:0005886,cellular_component,plasma membrane;GO:0001702,biological_process,gastrulation with mouth forming second;GO:0030111,biological_process,regulation of Wnt signaling pathway;GO:0042577,molecular_function,lipid phosphatase activity;GO:0016021,cellular_component,integral component of membrane;GO:0001568,biological_process,blood vessel development","K01080,ko00600,Sphingolipid metabolism;K01080,ko04666,Fc gamma R-mediated phagocytosis;K01080,ko00564,Glycerophospholipid metabolism;K01080,ko00565,Ether lipid metabolism;K01080,ko04975,Fat digestion and absorption;K01080,ko04072,Phospholipase D signaling pathway;K01080,ko05231,Choline metabolism in cancer;K01080,ko00561,Glycerolipid metabolism"]
["RP11-134G8.10",8.735991967,1.095864365,2.930523587,1.891634689,0.001488068,0.003456622,"-","-","-","-","-","-","-","-"]
["PAPSS2",1.279481557,0.16050132,2.930523587,1.891634689,0.001488068,0.003456622,"ENSG00000198682","H2R2G5,Uncharacterized protein","-","PF01583,Adenylylsulphate kinase;PF14306,PUA-like domain;PF01747,ATP-sulfurylase","IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR015947,PUA-like superfamily;IPR002891,Adenylyl-sulfate kinase;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR024951,Sulphate adenylyltransferase catalytic domain;IPR002650,Sulphate adenylyltransferase;IPR025980,ATP-sulfurylase PUA-like domain","KOG4238,Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase;KOG0635,Adenosine 5'-phosphosulfate kinase;COG2046,ATP sulfurylase (sulfate adenylyltransferase);COG0529,Adenylylsulfate kinase and related kinases","GO:0000103,biological_process,sulfate assimilation;GO:0016310,biological_process,phosphorylation;GO:0050428,biological_process,3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0004020,molecular_function,adenylylsulfate kinase activity;GO:0005524,molecular_function,ATP binding;GO:0004781,molecular_function,sulfate adenylyltransferase (ATP) activity","-"]
["RP11-625H11.2",9.053939681,1.13574851,2.930523587,1.891634689,0.001488068,0.003456622,"ENSG00000259756","H2PBI0,Uncharacterized protein","-","-","-","-","-","-"]
["PLCD4",0.890424952,0.111697101,2.930523587,1.891634689,0.001488068,0.003456622,"ENSG00000115556","C9JEA7,Phosphoinositide phospholipase C","XP_016860605.1,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2","PF09279,Phosphoinositide-specific phospholipase C, efhand-like;PF00388,Phosphatidylinositol-specific phospholipase C, X domain;PF00387,Phosphatidylinositol-specific phospholipase C, Y domain;PF00168,C2 domain;PF00169,PH domain","IPR018247,EF-Hand 1, calcium-binding site;IPR001192,Phosphoinositide phospholipase C family;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily;IPR028387,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR002048,EF-hand domain;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR011992,EF-hand domain pair;IPR001711,Phospholipase C, phosphatidylinositol-specific, Y domain;IPR000909,Phosphatidylinositol-specific phospholipase C, X domain;IPR015359,Phosphoinositide-specific phospholipase C, EF-hand-like domain","KOG0169,Phosphoinositide-specific phospholipase C;ENOG410XPSW,-","GO:0006629,biological_process,lipid metabolic process;GO:0004435,molecular_function,phosphatidylinositol phospholipase C activity;GO:0016787,molecular_function,hydrolase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0007340,biological_process,acrosome reaction;GO:0004871,molecular_function,signal transducer activity;GO:0016042,biological_process,lipid catabolic process;GO:0004629,molecular_function,phospholipase C activity;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0005886,cellular_component,plasma membrane;GO:0005622,cellular_component,intracellular;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol;GO:0005509,molecular_function,calcium ion binding;GO:0046488,biological_process,phosphatidylinositol metabolic process;GO:0007165,biological_process,signal transduction","-"]
["KIAA1549L",0.828932152,0.106401508,2.929191486,2.730764317,{"v":7.46e-06,"d":"7.46E-06"},{"v":2.92e-05,"d":"2.92E-05"},"ENSG00000110427","G3QNL6,KIAA1549 like","-","PF12877,omain of unknown function (DUF3827)","IPR024606,Protein of unknown function DUF3827","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["UVRAG",1.607491538,0.206337182,2.929191486,2.730764317,{"v":7.46e-06,"d":"7.46E-06"},{"v":2.92e-05,"d":"2.92E-05"},"ENSG00000198382","Q6P1X0,UV radiation resistance associated protein","-","PF10186,Vacuolar sorting 38 and autophagy-related subunit 14","IPR000008,C2 domain;IPR018791,UV radiation resistance protein/autophagy-related protein 14;IPR035892,C2 domain superfamily","ENOG410YZ0H,-;KOG2896,UV radiation resistance associated protein","-","-"]
["TET2",17.4268129,2.287319181,2.92843486,7.35403304,{"v":8.8e-32,"d":"8.80E-32"},{"v":2.62e-29,"d":"2.62E-29"},"ENSG00000168769","E7EQS8,Methylcytosine dioxygenase TET2","-","PF12851,Oxygenase domain of the 2OGFeDO superfamily","IPR024779,2OGFeDO, oxygenase domain","ENOG410IE22,-;ENOG410XPWW,-","GO:0005515,molecular_function,protein binding","-"]
["PRDM1",4.324913935,0.565912686,2.922109599,4.05403072,{"v":1.03e-11,"d":"1.03E-11"},{"v":1.47e-10,"d":"1.47E-10"},"ENSG00000057657","G3QHR5,PR/SET domain 1","XP_004044513.1,PR domain zinc finger protein 1","PF00856,SET domain;PF13912,C2H2-type zinc finger;PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR001214,SET domain;IPR036236,Zinc finger C2H2 superfamily","-","GO:0042462,biological_process,eye photoreceptor cell development;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0060707,biological_process,trophoblast giant cell differentiation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:1990654,biological_process,sebum secreting cell proliferation;GO:0003281,biological_process,ventricular septum development;GO:0035904,biological_process,aorta development;GO:0005634,cellular_component,nucleus;GO:0003170,biological_process,heart valve development;GO:0042826,molecular_function,histone deacetylase binding;GO:0060976,biological_process,coronary vasculature development;GO:0048844,biological_process,artery morphogenesis;GO:0001893,biological_process,maternal placenta development;GO:0007281,biological_process,germ cell development;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0051136,biological_process,regulation of NK T cell differentiation;GO:0010629,biological_process,negative regulation of gene expression;GO:0003279,biological_process,cardiac septum development;GO:0031665,biological_process,negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0045579,biological_process,positive regulation of B cell differentiation;GO:0042127,biological_process,regulation of cell proliferation;GO:0010628,biological_process,positive regulation of gene expression;GO:0045165,biological_process,cell fate commitment;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0032823,biological_process,regulation of natural killer cell differentiation;GO:0060576,biological_process,intestinal epithelial cell development;GO:0009791,biological_process,post-embryonic development;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0033082,biological_process,regulation of extrathymic T cell differentiation;GO:0001763,biological_process,morphogenesis of a branching structure;GO:0001892,biological_process,embryonic placenta development;GO:0005737,cellular_component,cytoplasm;GO:0001701,biological_process,in utero embryonic development;GO:0030889,biological_process,negative regulation of B cell proliferation","-"]
["TCF12",8.949376638,1.179394149,2.919878013,5.614551407,1.34E-21,{"v":1.41e-19,"d":"1.41E-19"},"ENSG00000140262","A0A024R5Z0,Transcription factor 12","NP_996919.1,transcription factor 12 isoform a;NP_001309080.1,-;NP_001309091.1,-;NP_996920.1,-;NP_001309088.1,-","PF00010,Helix-loop-helix DNA-binding domain","IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","KOG3910,Helix loop helix transcription factor;ENOG410XYUA,-","GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding;GO:0016607,cellular_component,nuclear speck;GO:0005667,cellular_component,transcription factor complex;GO:0071837,molecular_function,HMG box domain binding;GO:0035497,molecular_function,cAMP response element binding;GO:0070888,molecular_function,E-box binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0046982,molecular_function,protein heterodimerization activity;GO:0010628,biological_process,positive regulation of gene expression;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["LMLN",9.643744971,1.281702385,2.907673946,5.603967711,2.24E-21,{"v":2.34e-19,"d":"2.34E-19"},"ENSG00000185621","H2QP23,Leishmanolysin like peptidase","-","PF01457,Leishmanolysin","IPR001577,Peptidase M8, leishmanolysin","ENOG410XSAG,-;KOG2556,Leishmanolysin-like peptidase (Peptidase M8 family)","GO:0006508,biological_process,proteolysis;GO:0007155,biological_process,cell adhesion;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TRIM9",0.849494092,0.109892715,2.907375445,2.355757346,{"v":6.48e-05,"d":"6.48E-05"},2.04501E-4,"ENSG00000100505","G3QS61,Tripartite motif containing 9","XP_004055212.1,E3 ubiquitin-protein ligase TRIM9 isoform X5","PF00041,ibronectin type III domain;PF13920,Zinc finger, C3HC4 type (RING finger);PF00643,B-box zinc finger;PF00622,SPRY domain","IPR003961,Fibronectin type III;IPR017903,COS domain;IPR017907,Zinc finger, RING-type, conserved site;IPR001870,B30.2/SPRY domain;IPR003649,B-box, C-terminal;IPR036116,Fibronectin type III superfamily;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013783,Immunoglobulin-like fold;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000315,B-box-type zinc finger;IPR003877,SPRY domain;IPR035029,E3 ubiquitin-protein ligase TRIM9","-","GO:0016567,biological_process,protein ubiquitination;GO:0035544,biological_process,negative regulation of SNARE complex assembly;GO:0046872,molecular_function,metal ion binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0005622,cellular_component,intracellular;GO:0008270,molecular_function,zinc ion binding","-"]
["ARSK",1.761410443,0.227860532,2.907375445,2.355757346,{"v":6.48e-05,"d":"6.48E-05"},2.04501E-4,"ENSG00000164291","G3QSM2,Arylsulfatase family member K","XP_004042323.1,arylsulfatase K","PF00884,Sulfatase","IPR000917,Sulfatase, N-terminal;IPR017850,Alkaline-phosphatase-like, core domain superfamily;IPR017849,Alkaline phosphatase-like, alpha/beta/alpha","-","GO:0008484,molecular_function,sulfuric ester hydrolase activity;GO:0003824,molecular_function,catalytic activity;GO:0008152,biological_process,metabolic process","-"]
["ZNF34",3.419768069,0.44238989,2.907375445,2.355757346,{"v":6.48e-05,"d":"6.48E-05"},2.04501E-4,"ENSG00000196378","G3QKN9,Zinc finger protein 34","XP_018887606.1,zinc finger protein 34 isoform X2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR030753,Zinc finger protein 34;IPR013087,Zinc finger C2H2-type;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily;IPR001909,Krueppel-associated box","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["GPRC5B",2.243886179,0.294882356,2.906063556,3.233120092,{"v":6.35e-08,"d":"6.35E-08"},{"v":3.9e-07,"d":"3.90E-07"},"ENSG00000167191","A0A1D5Q3V3,G protein-coupled receptor class C group 5 member B","-","-","IPR017978,GPCR family 3, C-terminal","-","GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-96D1.10",4.950360408,0.650556145,2.906063556,3.233120092,{"v":6.35e-08,"d":"6.35E-08"},{"v":3.9e-07,"d":"3.90E-07"},"ENSG00000263276","G1S510,Uncharacterized protein","-","-","-","-","-","-"]
["EXD3",1.307805678,0.171866481,2.895359553,2.70351565,{"v":1.15E-5,"d":"1.15E-05"},{"v":4.31e-05,"d":"4.31E-05"},"ENSG00000187609","A0A140VJP9,Testicular tissue protein Li 125","-","PF01927,Mut7-C RNAse domain;PF01612,3'-5' exonuclease","IPR036397,Ribonuclease H superfamily;IPR037432,Exonuclease Mut-7, DEDDy 3'-5' exonuclease domain;IPR002782,Mut7-C RNAse domain;IPR012337,Ribonuclease H-like superfamily;IPR002562,3'-5' exonuclease domain","-","GO:0008408,molecular_function,3'-5' exonuclease activity;GO:0003676,molecular_function,nucleic acid binding;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0006139,biological_process,nucleobase-containing compound metabolic process","-"]
["AC007319.1",15.00257711,2.003377042,2.890209741,3.756736763,{"v":3.4e-10,"d":"3.40E-10"},{"v":3.48E-9,"d":"3.48E-09"},"-","-","-","-","-","-","-","-"]
["MYB",4.020351996,0.536859823,2.890209741,3.756736763,{"v":3.4e-10,"d":"3.40E-10"},{"v":3.48E-9,"d":"3.48E-09"},"ENSG00000118513","H9YZM1,Transcriptional activator Myb isoform 1","-","PF07988,LMSTEN motif;PF09316,C-myb, C-terminal;PF00249,Myb-like DNA-binding domain","IPR015395,C-myb, C-terminal;IPR012642,Transcription regulator Wos2-domain;IPR009057,Homeobox-like domain superfamily;IPR001005,SANT/Myb domain;IPR017930,Myb domain","KOG0048,Transcription factor, Myb superfamily;COG5147,Myb superfamily proteins, including transcription factors and mRNA splicing factors","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding","-"]
["AUTS2",16.22568363,2.201193969,2.880051352,6.602817625,{"v":3.28e-27,"d":"3.28E-27"},{"v":7.24e-25,"d":"7.24E-25"},"ENSG00000158321","K7ALG4,Autism susceptibility candidate 2","XP_519135.4,autism susceptibility gene 2 protein isoform X3","PF15336,Autism susceptibility gene 2 protein","IPR023246,Autism susceptibility gene 2 protein","ENOG410IGMF,-;ENOG4111MEB,-","GO:0051571,biological_process,positive regulation of histone H3-K4 methylation;GO:0003682,molecular_function,chromatin binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:2000620,biological_process,positive regulation of histone H4-K16 acetylation","-"]
["ISL1",6.756326132,0.909544608,2.876749973,3.588219992,{"v":4.03e-09,"d":"4.03E-09"},{"v":3.24e-08,"d":"3.24E-08"},"ENSG00000016082","L8IQ01,Insulin enhancer protein ISL-1","-","PF00046,Homeobox domain;PF00412,LIM domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR001781,Zinc finger, LIM-type","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding","-"]
["RP11-458D21.1",1.062677623,0.1333049,2.869680294,1.106087314,0.013951236,0.025691412,"-","-","-","-","-","-","-","-"]
["RP11-342D11.2",3.344509088,0.419543464,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000238258","Q5JWQ4,Neuropilin-1","-","PF00431,CUB domain;PF00754,5/8 type C domain","IPR000421,Coagulation factor 5/8 C-terminal domain;IPR035914,Spermadhesin, CUB domain superfamily;IPR027146,Neuropilin-1;IPR000859,CUB domain;IPR008979,Galactose-binding-like domain superfamily;IPR014648,Neuropilin","ENOG410IE8T,-;ENOG410YRBE,-","GO:0017154,molecular_function,semaphorin receptor activity;GO:0007411,biological_process,axon guidance;GO:0071526,biological_process,semaphorin-plexin signaling pathway;GO:0048010,biological_process,vascular endothelial growth factor receptor signaling pathway;GO:0019838,molecular_function,growth factor binding;GO:0038084,biological_process,vascular endothelial growth factor signaling pathway;GO:0001525,biological_process,angiogenesis;GO:0035767,biological_process,endothelial cell chemotaxis;GO:0009887,biological_process,animal organ morphogenesis;GO:0005021,molecular_function,vascular endothelial growth factor-activated receptor activity","-"]
["BMS1P1",0.572694935,0.071840264,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000204177","H2NC69,Uncharacterized protein","-","PF08142,AARP2CN (NUC121) domain","IPR037875,Ribosome biogenesis protein Bms1, N-terminal;IPR030387,Bms1/Tsr1-type G domain;IPR012948,AARP2CN;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG1951,GTP-binding protein AARP2 involved in 40S ribosome biogenesis;COG5192,GTP-binding protein required for 40S ribosome biogenesis","GO:0042254,biological_process,ribosome biogenesis;GO:0005525,molecular_function,GTP binding;GO:0005634,cellular_component,nucleus","-"]
["RP11-369J21.12",5.715670893,0.716987845,2.869680294,1.106087314,0.013951236,0.025691412,"-","-","-","-","-","-","-","-"]
["MFSD13A",0.740800226,0.092927806,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000138111","G3R6J3,Major facilitator superfamily domain containing 13A","XP_004050071.1,transmembrane protein 180","PF13347,MFS/sugar transport protein","IPR036259,MFS transporter superfamily","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP1-267D11.6",1.247402864,0.15647729,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000277283","A0A096MYY3,Uncharacterized protein","-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005546,molecular_function,phosphatidylinositol-4,5-bisphosphate binding;GO:0036010,biological_process,protein localization to endosome;GO:0019003,molecular_function,GDP binding;GO:0019882,biological_process,antigen processing and presentation;GO:0005525,molecular_function,GTP binding;GO:0031253,cellular_component,cell projection membrane;GO:0045171,cellular_component,intercellular bridge;GO:0048227,biological_process,plasma membrane to endosome transport;GO:0005905,cellular_component,clathrin-coated pit;GO:0000281,biological_process,mitotic cytokinesis;GO:0005886,cellular_component,plasma membrane;GO:0045334,cellular_component,clathrin-coated endocytic vesicle;GO:0016197,biological_process,endosomal transport;GO:0008104,biological_process,protein localization;GO:0003924,molecular_function,GTPase activity;GO:0031175,biological_process,neuron projection development;GO:0005739,cellular_component,mitochondrion","-"]
["RP11-151A6.4",0.718586409,0.09014125,2.869680294,1.106087314,0.013951236,0.025691412,"-","-","-","-","-","-","-","-"]
["UBL7-AS1",1.527521402,0.19161605,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000247240","Q8WZ27,Uncharacterized protein","-","-","-","ENOG410YXNP,-;ENOG410JGEY,-","-","-"]
["CEMIP",0.342745256,0.04299481,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000103888","G3QPF6,Cell migration inducing hyaluronan binding protein","XP_018866438.1,cell migration-inducing and hyaluronan-binding protein isoform X2","PF10162,8 domain;PF15711,Interleukin-like EMT inducer;PF13330,Mucin-2 protein WxxW repeating region","IPR025155,WxxW domain;IPR011050,Pectin lyase fold/virulence factor;IPR019316,G8 domain","-","GO:0051281,biological_process,positive regulation of release of sequestered calcium ion into cytosol;GO:0032050,molecular_function,clathrin heavy chain binding;GO:0046923,molecular_function,ER retention sequence binding;GO:0090314,biological_process,positive regulation of protein targeting to membrane;GO:0004415,molecular_function,hyalurononglucosaminidase activity;GO:0005737,cellular_component,cytoplasm;GO:0005540,molecular_function,hyaluronic acid binding;GO:0007605,biological_process,sensory perception of sound;GO:0045334,cellular_component,clathrin-coated endocytic vesicle;GO:0030214,biological_process,hyaluronan catabolic process;GO:0010800,biological_process,positive regulation of peptidyl-threonine phosphorylation;GO:0005886,cellular_component,plasma membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:1900020,biological_process,positive regulation of protein kinase C activity;GO:0030665,cellular_component,clathrin-coated vesicle membrane;GO:0030335,biological_process,positive regulation of cell migration","-"]
["PRSS54",1.23677159,0.155143677,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000103023","A0A140VKC3,Testis tissue sperm-binding protein Li 40a","NP_001292102.1,-;NP_001073961.1,inactive serine protease 54 isoform 1 precursor","PF00089,Trypsin","IPR009003,Peptidase S1, PA clan;IPR001254,Serine proteases, trypsin domain","-","GO:0006508,biological_process,proteolysis;GO:0004252,molecular_function,serine-type endopeptidase activity","-"]
["XAF1",0.394869478,0.049533401,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000132530","H2QC14,XIAP associated factor 1","XP_016786870.1,XIAP-associated factor 1 isoform X1","-","IPR031220,XIAP-associated factor 1;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001293,Zinc finger, TRAF-type","ENOG410IK96,-;ENOG4110HW5,-","GO:0006915,biological_process,apoptotic process;GO:0034097,biological_process,response to cytokine;GO:0046872,molecular_function,metal ion binding;GO:0035456,biological_process,response to interferon-beta;GO:0005739,cellular_component,mitochondrion;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["AC005224.2",1.699454521,0.213183764,2.869680294,1.106087314,0.013951236,0.025691412,"-","-","-","-","-","-","-","-"]
["RP11-455O6.2",3.244797016,0.407035336,2.869680294,1.106087314,0.013951236,0.025691412,"-","-","-","-","-","-","-","-"]
["KC6",0.504258996,0.063255491,2.869680294,1.106087314,0.013951236,0.025691412,"-","-","-","-","-","-","-","-"]
["SPRED3",0.445440245,0.055877122,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000188766","K7EPU5,Sprouty-related, EVH1 domain-containing protein 3","-","PF00568,WH1 domain;PF05210,Sprouty protein (Spry)","IPR007875,Sprouty;IPR023337,c-Kit-binding domain;IPR011993,PH-like domain superfamily;IPR000697,WH1/EVH1 domain","ENOG41112SS,-;KOG4590,Signal transduction protein Enabled, contains WH1 domain","GO:0009966,biological_process,regulation of signal transduction;GO:0007275,biological_process,multicellular organism development;GO:0016020,cellular_component,membrane","-"]
["ACP7",0.840702156,0.105459751,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000183760","K7DA91,Purple acid phosphatase","XP_016791381.1,-;XP_016791383.1,-;XP_016791382.1,-;XP_009433839.1,acid phosphatase type 7 isoform X1","PF00149,Calcineurin-like phosphoesterase;PF16656,Purple acid Phosphatase, N-terminal domain;PF14008,Iron/zinc purple acid phosphatase-like protein C","IPR029052,Metallo-dependent phosphatase-like;IPR004843,Calcineurin-like phosphoesterase domain, ApaH type;IPR015914,Purple acid phosphatase, N-terminal;IPR025733,Iron/zinc purple acid phosphatase-like C-terminal domain;IPR008963,Purple acid phosphatase-like, N-terminal","-","GO:0003993,molecular_function,acid phosphatase activity;GO:0016787,molecular_function,hydrolase activity;GO:0046872,molecular_function,metal ion binding;GO:0016311,biological_process,dephosphorylation","-"]
["CEACAM5",0.779487197,0.097780795,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000105388","A0A024R0K5,Carcinoembryonic antigen-related cell adhesion molecule 5","NP_001278413.1,-;NP_004354.3,carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein","PF13927,Immunoglobulin domain;PF07686,Immunoglobulin V-set domain;PF13895,Immunoglobulin domain","IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain","ENOG410YR1P,-;ENOG410IFE1,-","GO:0005886,cellular_component,plasma membrane","-"]
["C19orf18",2.854712129,0.358102126,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000177025","H2QHB2,Uncharacterized protein","XP_016792466.1,uncharacterized protein C19orf18 homolog","-","IPR037549,Uncharacterized protein C19orf18","ENOG411140P,-;ENOG410IZPS,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PLB1",0.317074727,0.039774635,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000163803","B2RWP8,Phospholipase B1","NP_694566.4,phospholipase B1, membrane-associated isoform 1 precursor;NP_001164056.1,phospholipase B1, membrane-associated isoform 2 precursor","PF00657,SL-like Lipase/Acylhydrolase","IPR001087,GDSL lipase/esterase;IPR035547,Phospholipase B;IPR008265,Lipase, GDSL, active site;IPR036514,SGNH hydrolase superfamily","ENOG4111FH4,-;KOG3670,Phospholipase","GO:0006629,biological_process,lipid metabolic process;GO:0016788,molecular_function,hydrolase activity, acting on ester bonds;GO:0016298,molecular_function,lipase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K14621,ko00565,Ether lipid metabolism;K14621,ko00590,Arachidonic acid metabolism;K14621,ko00591,Linoleic acid metabolism;K14621,ko00564,Glycerophospholipid metabolism;K14621,ko04977,Vitamin digestion and absorption;K14621,ko00592,alpha-Linolenic acid metabolism"]
["ACYP2",0.526200967,0.066007946,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000170634","U3KQL2,Acylphosphatase","NP_001307515.1,acylphosphatase-2 isoform 1","PF00708,Acylphosphatase","IPR017968,Acylphosphatase, conserved site;IPR001792,Acylphosphatase-like domain;IPR036046,Acylphosphatase-like domain superfamily;IPR020456,Acylphosphatase","KOG3360,Acylphosphatase;ENOG41126ER,-","GO:0016787,molecular_function,hydrolase activity;GO:0003998,molecular_function,acylphosphatase activity","-"]
["PKI55",0.829752731,0.104086228,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000260804","Q9NT46,Uncharacterized protein DKFZp434H1419","-","-","-","-","-","-"]
["DNAH1",0.188297405,0.023620491,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000114841","A0A140VJI6,Testicular tissue protein Li 60","NP_056327.4,dynein heavy chain 1, axonemal;XP_016861619.1,-","PF12774,Hydrolytic ATP binding site of dynein motor region D1;PF12777,Microtubule-binding stalk of dynein motor;PF07728,AAA domain (dynein-related subfamily);PF03028,ynein heavy chain and region D6 of dynein motor;PF12780,P-loop containing dynein motor region D4;PF08393,ynein heavy chain, N-terminal region 2;PF12781,ATP-binding dynein motor region D5;PF12775,P-loop containing dynein motor region D3","IPR035699,Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;IPR024743,Dynein heavy chain, coiled coil stalk;IPR026983,Dynein heavy chain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004273,Dynein heavy chain domain;IPR013602,Dynein heavy chain, domain-2;IPR035706,Dynein heavy chain, ATP-binding dynein motor region D5;IPR011704,ATPase, dynein-related, AAA domain;IPR026975,Dynein heavy chain 1, axonemal;IPR024317,Dynein heavy chain, AAA module D4","-","GO:0005858,cellular_component,axonemal dynein complex;GO:0003777,molecular_function,microtubule motor activity;GO:0003341,biological_process,cilium movement;GO:0016887,molecular_function,ATPase activity;GO:0007018,biological_process,microtubule-based movement;GO:0030286,cellular_component,dynein complex;GO:0005524,molecular_function,ATP binding","K10408,ko05016,Huntington's disease"]
["RP11-561O4.1",1.470755404,0.184495183,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000239455","A0A1U7R481,Tyrosine-protein phosphatase non-receptor type","XP_005080709.1,tyrosine-protein phosphatase non-receptor type 11 isoform X2","-","IPR029021,Protein-tyrosine phosphatase-like;IPR036860,SH2 domain superfamily;IPR000242,PTP type protein phosphatase;IPR016130,Protein-tyrosine phosphatase, active site;IPR000980,SH2 domain;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR000387,Tyrosine specific protein phosphatases domain;IPR012152,Protein-tyrosine phosphatase, non-receptor type-6, -11","-","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","-"]
["RP11-211G3.3",3.643042675,0.456992253,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000228804","H2RIH4,Uncharacterized protein","-","-","-","-","-","-"]
["PARM1",0.518883909,0.065090076,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000169116","G3R7B8,Prostate androgen-regulated mucin-like protein 1","XP_004038883.1,prostate androgen-regulated mucin-like protein 1 isoform X2","PF17061,PARM","IPR031431,Prostate androgen-regulated mucin-like protein 1","-","GO:0005794,cellular_component,Golgi apparatus;GO:0005770,cellular_component,late endosome;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005886,cellular_component,plasma membrane;GO:0005769,cellular_component,early endosome;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","-"]
["RP1-151F17.1",3.742208593,0.46943187,2.869680294,1.106087314,0.013951236,0.025691412,"-","-","-","-","-","-","-","-"]
["RP5-981O7.2",3.8812208,0.486869904,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000229591","G1QXD4,Polypeptide N-acetylgalactosaminyltransferase","XP_012367499.1,-;XP_012367498.1,polypeptide N-acetylgalactosaminyltransferase 11 isoform X1","PF00535,lycosyl transferase family 2;PF00652,Ricin-type beta-trefoil lectin domain","IPR035992,Ricin B-like lectins;IPR000772,Ricin B, lectin domain;IPR029044,Nucleotide-diphospho-sugar transferases;IPR001173,Glycosyltransferase 2-like","ENOG410XPMK,-;KOG3736,Polypeptide N-acetylgalactosaminyltransferase","GO:0018243,biological_process,protein O-linked glycosylation via threonine;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0006486,biological_process,protein glycosylation;GO:0016740,molecular_function,transferase activity;GO:0005794,cellular_component,Golgi apparatus;GO:0030246,molecular_function,carbohydrate binding;GO:0004653,molecular_function,polypeptide N-acetylgalactosaminyltransferase activity;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0005112,molecular_function,Notch binding;GO:0016021,cellular_component,integral component of membrane","-"]
["TMX2P1",3.68935254,0.462801476,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000213839","K7AYW1,Thioredoxin-related transmembrane protein 2","-","PF00085,Thioredoxin","IPR013766,Thioredoxin domain;IPR036249,Thioredoxin-like superfamily;IPR037463,Thioredoxin-related transmembrane protein 2, thioredoxin domain","-","GO:0045454,biological_process,cell redox homeostasis;GO:0005623,cellular_component,cell;GO:0016021,cellular_component,integral component of membrane","-"]
["PLCXD1",0.421912712,0.05292577,2.869680294,1.106087314,0.013951236,0.025691412,"ENSG00000182378","K7ARN9,Phosphatidylinositol-specific phospholipase C, X domain containing 1","-","PF00388,Phosphatidylinositol-specific phospholipase C, X domain","IPR000909,Phosphatidylinositol-specific phospholipase C, X domain;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily","-","GO:0006629,biological_process,lipid metabolic process;GO:0008081,molecular_function,phosphoric diester hydrolase activity","-"]
["NCOA6",32.42650443,4.444989687,2.8660558,7.689447252,{"v":4.52e-32,"d":"4.52E-32"},{"v":1.4e-29,"d":"1.40E-29"},"ENSG00000198646","G1RGH1,Nuclear receptor coactivator 6","-","PF13820,Putative nucleic acid-binding region","IPR032715,Nuclear receptor coactivator 6, putative nucleic acid-binding region","ENOG410XW4F,-;ENOG410IK20,-","GO:0019899,molecular_function,enzyme binding;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0003713,molecular_function,transcription coactivator activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030099,biological_process,myeloid cell differentiation;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0006352,biological_process,DNA-templated transcription, initiation;GO:0046966,molecular_function,thyroid hormone receptor binding;GO:0005634,cellular_component,nucleus;GO:0005829,cellular_component,cytosol;GO:0035097,cellular_component,histone methyltransferase complex;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity;GO:0005654,cellular_component,nucleoplasm","-"]
["SYNC",1.43007257,0.187934296,2.863859003,1.841273024,0.002426099,0.005369716,"ENSG00000162520","K7CJH9,Syncoilin, intermediate filament protein","XP_016813872.1,syncoilin isoform X1","PF00038,Intermediate filament protein","IPR001664,Intermediate filament protein;IPR027702,Syncoilin","ENOG410IKIK,-;ENOG410Y2YI,-","GO:0005882,cellular_component,intermediate filament;GO:0005198,molecular_function,structural molecule activity","-"]
["ELP4",2.247256895,0.295325322,2.863859003,1.841273024,0.002426099,0.005369716,"ENSG00000109911","G5E9D4,Elongation protein 4 homolog","NP_001275655.1,elongator complex protein 4 isoform 3","PF05625,PAXNEB protein","IPR008728,Elongator complex protein 4","KOG3949,RNA polymerase II elongator complex, subunit ELP4;ENOG410XP5H,-","GO:0033588,cellular_component,Elongator holoenzyme complex;GO:0002098,biological_process,tRNA wobble uridine modification;GO:0005654,cellular_component,nucleoplasm","-"]
["CTD-2562J17.6",2.132875556,0.280293794,2.863859003,1.841273024,0.002426099,0.005369716,"-","-","-","-","-","-","-","-"]
["ARHGAP42",0.718125439,0.094373112,2.863859003,1.841273024,0.002426099,0.005369716,"ENSG00000165895","G3R6Z3,Rho GTPase activating protein 42","XP_018893191.1,-","PF14604,Variant SH3 domain;PF16746,BAR domain of APPL family;PF00620,RhoGAP domain;PF00169,PH domain","IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR027267,AH/BAR domain superfamily;IPR001452,SH3 domain;IPR008936,Rho GTPase activation protein;IPR036028,SH3-like domain superfamily;IPR000198,Rho GTPase-activating protein domain","-","GO:0005096,molecular_function,GTPase activator activity;GO:0007165,biological_process,signal transduction;GO:0090630,biological_process,activation of GTPase activity","-"]
["RP11-860B13.1",7.344128205,0.965135332,2.863859003,1.841273024,0.002426099,0.005369716,"ENSG00000256747","A0A096NGJ6,Kelch like family member 42","XP_003906207.1,kelch-like protein 42","PF01344,Kelch motif;PF07707,BTB And C-terminal Kelch","IPR006652,Kelch repeat type 1;IPR011705,BTB/Kelch-associated;IPR000210,BTB/POZ domain;IPR015915,Kelch-type beta propeller;IPR011333,SKP1/BTB/POZ domain superfamily","-","GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209,biological_process,protein polyubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0032886,biological_process,regulation of microtubule-based process;GO:0031463,cellular_component,Cul3-RING ubiquitin ligase complex","-"]
["CHADL",1.918685283,0.252145783,2.863859003,1.841273024,0.002426099,0.005369716,"ENSG00000100399","H2R6Z0,Uncharacterized protein","XP_016794744.1,chondroadherin-like protein isoform X3","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR000372,Leucine-rich repeat N-terminal domain;IPR003591,Leucine-rich repeat, typical subtype;IPR000483,Cysteine-rich flanking region, C-terminal;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0098633,molecular_function,collagen fibril binding;GO:0031012,cellular_component,extracellular matrix;GO:0005518,molecular_function,collagen binding;GO:1904027,biological_process,negative regulation of collagen fibril organization;GO:0032331,biological_process,negative regulation of chondrocyte differentiation","-"]
["ALG1L6P",6.578711149,0.864547348,2.863859003,1.841273024,0.002426099,0.005369716,"ENSG00000238278","H2QAJ3,ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase","XP_510796.2,chitobiosyldiphosphodolichol beta-mannosyltransferase","PF00534,lycosyl transferases group 1","IPR026051,Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like;IPR001296,Glycosyl transferase, family 1","KOG2941,Beta-1,4-mannosyltransferase;COG0438,Glycosyltransferase","GO:0097502,biological_process,mannosylation;GO:0006486,biological_process,protein glycosylation;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0005783,cellular_component,endoplasmic reticulum;GO:0000030,molecular_function,mannosyltransferase activity","K03842,ko00510,N-Glycan biosynthesis;K03842,ko00513,Various types of N-glycan biosynthesis"]
["RP11-22C11.2",2.28431656,0.300195552,2.863859003,1.841273024,0.002426099,0.005369716,"ENSG00000261437","B0YJ83,Protein tyrosine phosphatase-like, member A variant 4","-","-","-","COG5198,Protein tyrosine phosphatase-like protein (contains Pro instead of catalytic Arg);KOG3187,Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg)","-","-"]
["MAN1B1-AS1",2.663815732,0.350067783,2.863859003,1.841273024,0.002426099,0.005369716,"ENSG00000268996","Q8WUC7,Uncharacterized protein","-","-","-","ENOG4110NXA,-;ENOG410KCIR,-","-","-"]
["BBS10",2.047639639,0.273432638,2.861781597,2.319937055,1.03608E-4,0.000312415,"ENSG00000179941","B7Z8Z2,cDNA FLJ61630, highly similar to Bardet-Biedl syndrome 10 protein","-","PF00118,TCP-1/cpn60 chaperonin family","IPR027410,TCP-1-like chaperonin intermediate domain superfamily;IPR027413,GroEL-like equatorial domain superfamily;IPR027409,GroEL-like apical domain superfamily;IPR002423,Chaperonin Cpn60/TCP-1 family","KOG0360,Chaperonin complex component, TCP-1 alpha subunit (CCT1);COG0459,Chaperonin GroEL (HSP60 family)","GO:0005524,molecular_function,ATP binding","-"]
["SIX1",1.355665654,0.181029528,2.861781597,2.319937055,1.03608E-4,0.000312415,"ENSG00000126778","H2Q8E8,SIX homeobox 1","XP_509988.2,-","PF16878,Transcriptional regulator, SIX1, N-terminal SD domain;PF00046,Homeobox domain","IPR031278,Homeobox protein SIX1;IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR031701,Homeobox protein SIX1, N-terminal SD domain;IPR009057,Homeobox-like domain superfamily","KOG0775,Transcription factor SIX and related HOX domain proteins;ENOG410XRPB,-","GO:0042474,biological_process,middle ear morphogenesis;GO:0072107,biological_process,positive regulation of ureteric bud formation;GO:0050678,biological_process,regulation of epithelial cell proliferation;GO:0030855,biological_process,epithelial cell differentiation;GO:0034504,biological_process,protein localization to nucleus;GO:0060037,biological_process,pharyngeal system development;GO:0051451,biological_process,myoblast migration;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0010468,biological_process,regulation of gene expression;GO:0072513,biological_process,positive regulation of secondary heart field cardioblast proliferation;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0022008,biological_process,neurogenesis;GO:2000729,biological_process,positive regulation of mesenchymal cell proliferation involved in ureter development;GO:0048705,biological_process,skeletal system morphogenesis;GO:0030878,biological_process,thyroid gland development;GO:0071599,biological_process,otic vesicle development;GO:0005634,cellular_component,nucleus;GO:0042472,biological_process,inner ear morphogenesis;GO:0072075,biological_process,metanephric mesenchyme development;GO:0072001,biological_process,renal system development;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0048699,biological_process,generation of neurons;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0007605,biological_process,sensory perception of sound;GO:0001657,biological_process,ureteric bud development;GO:0061551,biological_process,trigeminal ganglion development;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0048704,biological_process,embryonic skeletal system morphogenesis;GO:0045664,biological_process,regulation of neuron differentiation;GO:0048839,biological_process,inner ear development;GO:0008582,biological_process,regulation of synaptic growth at neuromuscular junction;GO:0001822,biological_process,kidney development;GO:0003682,molecular_function,chromatin binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006915,biological_process,apoptotic process;GO:0003677,molecular_function,DNA binding;GO:0090103,biological_process,cochlea morphogenesis;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0048856,biological_process,anatomical structure development;GO:0048513,biological_process,animal organ development;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0072193,biological_process,ureter smooth muscle cell differentiation;GO:0035909,biological_process,aorta morphogenesis;GO:0048538,biological_process,thymus development;GO:0048665,biological_process,neuron fate specification;GO:0030910,biological_process,olfactory placode formation;GO:0090191,biological_process,negative regulation of branching involved in ureteric bud morphogenesis;GO:0003151,biological_process,outflow tract morphogenesis;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:2001014,biological_process,regulation of skeletal muscle cell differentiation;GO:0061055,biological_process,myotome development;GO:0001658,biological_process,branching involved in ureteric bud morphogenesis;GO:0032880,biological_process,regulation of protein localization;GO:0005667,cellular_component,transcription factor complex;GO:0005730,cellular_component,nucleolus;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0008283,biological_process,cell proliferation;GO:0001759,biological_process,organ induction;GO:0021610,biological_process,facial nerve morphogenesis;GO:0048701,biological_process,embryonic cranial skeleton morphogenesis;GO:0014842,biological_process,regulation of skeletal muscle satellite cell proliferation;GO:0007519,biological_process,skeletal muscle tissue development;GO:0061197,biological_process,fungiform papilla morphogenesis;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0090190,biological_process,positive regulation of branching involved in ureteric bud morphogenesis;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0072095,biological_process,regulation of branch elongation involved in ureteric bud branching;GO:0007389,biological_process,pattern specification process;GO:0072172,biological_process,mesonephric tubule formation;GO:0043586,biological_process,tongue development","K15614,ko05202,Transcriptional misregulation in cancer"]
["RNF166",1.675299159,0.223711956,2.861781597,2.319937055,1.03608E-4,0.000312415,"ENSG00000158717","G3RA09,Ring finger protein 166","XP_004058177.1,-","PF05605,rought induced 19 protein (Di19), zinc-binding;PF13923,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR017907,Zinc finger, RING-type, conserved site;IPR008598,Drought induced 19 protein type, zinc-binding domain;IPR034734,Zinc finger C2HC RNF-type","-","-","-"]
["TRMT10A",1.681037795,0.224478268,2.861781597,2.319937055,1.03608E-4,0.000312415,"ENSG00000145331","V9HVY8,Epididymis secretory protein Li 88","NP_001128137.1,-;NP_001128138.1,-;NP_689505.1,tRNA methyltransferase 10 homolog A;XP_006714480.1,-;XP_005263409.1,-","PF01746,tRNA (Guanine-1)-methyltransferase","IPR028564,tRNA methyltransferase TRM10-type domain;IPR016653,tRNA (guanine(9)-N(1))-methyltransferase TRM10/TRM10A;IPR007356,tRNA (guanine-N1-)-methyltransferase, eukaryotic;IPR038459,tRNA methyltransferase TRM10-type domain superfamily;IPR016009,tRNA methyltransferase TRMD/TRM10-type domain","ENOG4111JE4,-;KOG2967,Uncharacterized conserved protein","GO:0005730,cellular_component,nucleolus;GO:0015629,cellular_component,actin cytoskeleton;GO:0016740,molecular_function,transferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm","-"]
["HUS1",1.762332895,0.235334052,2.861781597,2.319937055,1.03608E-4,0.000312415,"ENSG00000136273","H2QUJ9,HUS1 checkpoint clamp component","XP_016812923.1,-;XP_016801187.1,-;XP_016801186.1,-;XP_519090.2,-","PF04005,Hus1-like protein","IPR016580,Cell cycle checkpoint, Hus1;IPR007150,Checkpoint protein Hus1/Mec3","KOG3999,Checkpoint 9-1-1 complex, HUS1 component;ENOG410ZQ9J,-","GO:0031573,biological_process,intra-S DNA damage checkpoint;GO:0035861,cellular_component,site of double-strand break;GO:0005730,cellular_component,nucleolus;GO:0033314,biological_process,mitotic DNA replication checkpoint;GO:0005634,cellular_component,nucleus;GO:0006289,biological_process,nucleotide-excision repair;GO:0044778,biological_process,meiotic DNA integrity checkpoint;GO:0000077,biological_process,DNA damage checkpoint;GO:0030896,cellular_component,checkpoint clamp complex;GO:0071479,biological_process,cellular response to ionizing radiation;GO:0000724,biological_process,double-strand break repair via homologous recombination","-"]
["TMCC3",1.49437697,0.201174794,2.860715153,2.675717581,{"v":1.76e-05,"d":"1.76E-05"},{"v":6.36e-05,"d":"6.36E-05"},"ENSG00000057704","H2Q6M3,Transmembrane and coiled-coil domain family 3","XP_001141714.1,-","PF10267,Predicted transmembrane and coiled-coil 2 protein","IPR019394,Testis-specific protein TEX28/transmembrane and coiled-coil domains protein","ENOG410Y9KV,-;KOG3850,Predicted membrane protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ATL1",2.232996779,0.300608665,2.860715153,2.675717581,{"v":1.76e-05,"d":"1.76E-05"},{"v":6.36e-05,"d":"6.36E-05"},"ENSG00000198513","A0A0S2Z5B0,Atlastin GTPase 1 isoform 1","NP_056999.2,atlastin-1 isoform a","PF02263,uanylate-binding protein, N-terminal domain","IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005794,cellular_component,Golgi apparatus;GO:0007409,biological_process,axonogenesis;GO:0005525,molecular_function,GTP binding;GO:0000137,cellular_component,Golgi cis cisterna;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005737,cellular_component,cytoplasm;GO:0071782,cellular_component,endoplasmic reticulum tubular network;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ZBED3",1.49460638,0.201205677,2.860715153,2.675717581,{"v":1.76e-05,"d":"1.76E-05"},{"v":6.36e-05,"d":"6.36E-05"},"ENSG00000132846","Q53EL5,Zinc finger, BED domain containing 3 variant","-","PF02892,BED zinc finger","IPR033546,Zinc finger BED domain-containing protein 3;IPR003656,Zinc finger, BED-type;IPR036236,Zinc finger C2H2 superfamily","ENOG410IXJY,-;ENOG41115R7,-","GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway;GO:0003677,molecular_function,DNA binding;GO:0050821,biological_process,protein stabilization","-"]
["MUC20P1",7.208611553,0.975188825,2.860066123,2.959184648,{"v":1.19E-6,"d":"1.19E-06"},{"v":5.54e-06,"d":"5.54E-06"},"ENSG00000224769","A0A0G2JN31,Mucin-20","NP_065841.1,mucin-20 isoform d precursor","-","IPR034551,Mucin-20","-","GO:0048012,biological_process,hepatocyte growth factor receptor signaling pathway","-"]
["RFX2",2.376168157,0.324276557,2.858894913,3.730565888,{"v":6.81e-10,"d":"6.81E-10"},{"v":6.52e-09,"d":"6.52E-09"},"ENSG00000087903","K7CLK7,Regulatory factor X, 2","-","PF04589,RFX1 transcription activation region;PF02257,RFX DNA-binding domain","IPR007668,RFX1 transcription activation region;IPR003150,DNA-binding RFX-type winged-helix domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR036390,Winged helix DNA-binding domain superfamily","ENOG410XSHE,-;KOG3712,RFX family transcription factor","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["TMEM184C",14.51369309,2.016604395,2.842924114,5.324697487,{"v":5.31e-19,"d":"5.31E-19"},3.57E-17,"ENSG00000164168","K7C5E2,Transmembrane protein 184C","XP_016807835.1,-;XP_016807834.1,-","PF03619,Organic solute transporter Ostalpha","IPR005178,Organic solute transporter subunit alpha/Transmembrane protein 184","KOG2641,Predicted seven transmembrane receptor - rhodopsin family;ENOG410XQ3V,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["KDM6A",2.660990562,0.367181336,2.841189706,3.558682745,{"v":5.79e-09,"d":"5.79E-09"},{"v":4.48e-08,"d":"4.48E-08"},"ENSG00000147050","A0A087X0R0,Lysine-specific demethylase 6A","-","PF02373,JmjC domain, hydroxylase;PF13432,Tetratricopeptide repeat;PF13181,Tetratricopeptide repeat","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR029516,Histone demethylase UTY;IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR003347,JmjC domain","KOG1246,DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain;KOG1124,FOG: TPR repeat;COG0457,FOG: TPR repeat","GO:0010468,biological_process,regulation of gene expression;GO:0071557,biological_process,histone H3-K27 demethylation;GO:0046872,molecular_function,metal ion binding;GO:0071558,molecular_function,histone demethylase activity (H3-K27 specific)","-"]
["ZHX3",3.248959909,0.451132873,2.840227206,4.496315892,{"v":6.92e-14,"d":"6.92E-14"},{"v":1.63e-12,"d":"1.63E-12"},"ENSG00000174306","F7AY25,Uncharacterized protein","-","PF11569,Homeodomain leucine-zipper encoding, Homez;PF00046,Homeobox domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR024578,Homez, homeobox domain","ENOG410IHET,-;ENOG410Z8A2,-","GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045669,biological_process,positive regulation of osteoblast differentiation;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["FUNDC1",11.88149405,1.639488288,2.838893673,3.380033669,{"v":5.56e-08,"d":"5.56E-08"},{"v":3.47e-07,"d":"3.47E-07"},"ENSG00000069509","H2R4R7,FUN14 domain containing 1","-","PF04930,UN14 family","IPR007014,FUN14","KOG4099,Predicted membrane protein;ENOG41122V1,-","GO:0000422,biological_process,autophagy of mitochondrion;GO:0031307,cellular_component,integral component of mitochondrial outer membrane","-"]
["POM121B",5.728833421,0.790502883,2.835839808,3.175474897,{"v":2.1E-7,"d":"2.10E-07"},{"v":1.15E-6,"d":"1.15E-06"},"ENSG00000205578","B4DET5,cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121","NP_001092885.2,nuclear envelope pore membrane protein POM 121C","PF15229,POM121 family","IPR026090,Nuclear pore protein POM121;IPR026054,Nuclear pore complex protein","ENOG410IM0V,-;ENOG4112BJY,-","-","K14316,ko03013,RNA transport"]
["S100A11",5472.757937,766.6360899,2.835572317,11.05163076,{"v":7.74e-38,"d":"7.74E-38"},{"v":2.83e-35,"d":"2.83E-35"},"ENSG00000163191","H2N5T5,Protein S100","XP_002810252.1,-","PF00036,hand;PF01023,S-100/ICaBP type calcium binding domain","IPR018247,EF-Hand 1, calcium-binding site;IPR013787,S100/CaBP-9k-type, calcium binding, subdomain;IPR028482,Protein S100-A11;IPR002048,EF-hand domain;IPR001751,S100/Calbindin-D9k, conserved site;IPR011992,EF-hand domain pair","ENOG410J1U7,-;ENOG410YYVE,-","GO:0042127,biological_process,regulation of cell proliferation;GO:0001726,cellular_component,ruffle;GO:0005737,cellular_component,cytoplasm;GO:0005913,cellular_component,cell-cell adherens junction;GO:0042803,molecular_function,protein homodimerization activity;GO:0046872,molecular_function,metal ion binding;GO:0005509,molecular_function,calcium ion binding;GO:0098609,biological_process,cell-cell adhesion;GO:0098641,molecular_function,cadherin binding involved in cell-cell adhesion;GO:0048306,molecular_function,calcium-dependent protein binding;GO:0044548,molecular_function,S100 protein binding;GO:0005634,cellular_component,nucleus;GO:0005576,cellular_component,extracellular region","-"]
["CDK17",4.316138275,0.600574514,2.834507802,4.098219071,{"v":1.5E-11,"d":"1.50E-11"},{"v":2.08e-10,"d":"2.08E-10"},"ENSG00000059758","H2Q6N5,Cyclin-dependent kinase 17","XP_001147273.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XPP3,-;KOG0594,Protein kinase PCTAIRE and related kinases","GO:0016301,molecular_function,kinase activity;GO:0004693,molecular_function,cyclin-dependent protein serine/threonine kinase activity;GO:0016310,biological_process,phosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus","-"]
["SEC24B",13.92274467,1.946266871,2.834464927,5.410943914,1.42E-19,{"v":1.1E-17,"d":"1.10E-17"},"ENSG00000138802","K7DTQ4,SEC24 family, member B","XP_016807495.1,protein transport protein Sec24B isoform X3","PF04815,Sec23/Sec24 helical domain;PF04811,Sec23/Sec24 trunk domain;PF08033,Sec23/Sec24 beta-sandwich domain;PF00626,elsolin repeat;PF04810,Sec23/Sec24 zinc finger","IPR007123,Gelsolin-like domain;IPR036180,Gelsolin-like domain superfamily;IPR036465,von Willebrand factor A-like domain superfamily;IPR006900,Sec23/Sec24, helical domain;IPR029006,ADF-H/Gelsolin-like domain superfamily;IPR006895,Zinc finger, Sec23/Sec24-type;IPR036175,Sec23/Sec24 helical domain superfamily;IPR006896,Sec23/Sec24, trunk domain;IPR012990,Sec23/Sec24 beta-sandwich;IPR036174,Zinc finger, Sec23/Sec24-type superfamily","COG5028,Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3;KOG1985,Vesicle coat complex COPII, subunit SEC24/subunit SFB2","GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0015031,biological_process,protein transport;GO:0008270,molecular_function,zinc ion binding;GO:0030127,cellular_component,COPII vesicle coat;GO:0006886,biological_process,intracellular protein transport","-"]
["USP42",12.25579087,1.714302527,2.834252577,5.659559569,{"v":7.41e-21,"d":"7.41E-21"},7.05E-19,"ENSG00000106346","A4D2N6,Ubiquitin specific protease 42","-","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","KOG1865,Ubiquitin carboxyl-terminal hydrolase;ENOG410XQ92,-","GO:0006508,biological_process,proteolysis;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function,peptidase activity;GO:0016579,biological_process,protein deubiquitination","-"]
["RP1-151F17.2",4.678095849,0.645515061,2.831578744,2.936087393,{"v":1.8e-06,"d":"1.80E-06"},{"v":8.07e-06,"d":"8.07E-06"},"-","-","-","-","-","-","-","-"]
["AC005262.3",21.01417215,2.899676505,2.825218302,2.647347231,{"v":2.71e-05,"d":"2.71E-05"},{"v":9.36e-05,"d":"9.36E-05"},"ENSG00000267139","A0A1S3MXA0,guanine nucleotide-binding protein subunit alpha-11-like isoform X2","XP_014005881.1,guanine nucleotide-binding protein subunit alpha-11-like isoform X2;XP_014007371.1,-","-","IPR011025,G protein alpha subunit, helical insertion;IPR000654,G-protein alpha subunit, group Q;IPR001019,Guanine nucleotide binding protein (G-protein), alpha subunit;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0001664,molecular_function,G-protein coupled receptor binding;GO:0005525,molecular_function,GTP binding;GO:0004871,molecular_function,signal transducer activity;GO:0019001,molecular_function,guanyl nucleotide binding;GO:0031683,molecular_function,G-protein beta/gamma-subunit complex binding;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0007165,biological_process,signal transduction","-"]
["SCMH1",25.0969796,3.536731586,2.824316096,6.018617157,{"v":4.89e-23,"d":"4.89E-23"},{"v":6.34e-21,"d":"6.34E-21"},"ENSG00000010803","H2RC67,Sex comb on midleg homolog 1","-","PF02820,mbt repeat;PF00536,SAM domain (Sterile alpha motif);PF17208,RNA binding Region;PF12140,SLED domain","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR004092,Mbt repeat;IPR038348,SLED domain superfamily;IPR021987,SLED domain;IPR033763,Polycomb group protein, RNA binding region;IPR001660,Sterile alpha motif domain","ENOG410XPKI,-;ENOG410IMEZ,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["COX10",42.29665261,5.991324027,2.817356203,6.28092058,{"v":1.78e-24,"d":"1.78E-24"},{"v":3.01e-22,"d":"3.01E-22"},"ENSG00000006695","H2QCB0,Protoheme IX farnesyltransferase, mitochondrial","-","PF01040,UbiA prenyltransferase family","IPR000537,UbiA prenyltransferase family;IPR006369,Protohaem IX farnesyltransferase;IPR030470,UbiA prenyltransferase conserved site","KOG1380,Heme A farnesyltransferase;COG0109,Polyprenyltransferase (cytochrome oxidase assembly factor)","GO:0007005,biological_process,mitochondrion organization;GO:0045333,biological_process,cellular respiration;GO:0006783,biological_process,heme biosynthetic process;GO:0008535,biological_process,respiratory chain complex IV assembly;GO:0009060,biological_process,aerobic respiration;GO:0005739,cellular_component,mitochondrion;GO:0006784,biological_process,heme a biosynthetic process;GO:0008495,molecular_function,protoheme IX farnesyltransferase activity;GO:0005829,cellular_component,cytosol;GO:0016021,cellular_component,integral component of membrane;GO:0022900,biological_process,electron transport chain;GO:0048034,biological_process,heme O biosynthetic process;GO:0016765,molecular_function,transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0004129,molecular_function,cytochrome-c oxidase activity;GO:0016740,molecular_function,transferase activity;GO:0031966,cellular_component,mitochondrial membrane;GO:0000266,biological_process,mitochondrial fission;GO:0016020,cellular_component,membrane;GO:0070069,cellular_component,cytochrome complex;GO:0017004,biological_process,cytochrome complex assembly;GO:0005730,cellular_component,nucleolus;GO:1902600,biological_process,proton transmembrane transport;GO:0004311,molecular_function,farnesyltranstransferase activity","-"]
["LRRC28",0.767734062,0.105937098,2.814699681,2.283157809,1.65623E-4,4.78009E-4,"ENSG00000168904","H2QA53,Leucine rich repeat containing 28","XP_009428194.1,-;XP_009428193.1,-;XP_001141916.2,leucine-rich repeat-containing protein 28 isoform X1","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction","-"]
["RP11-417N10.4",7.145240079,0.98594818,2.814699681,2.283157809,1.65623E-4,4.78009E-4,"ENSG00000279592","A0A096NSG8,Zinc finger protein 821","XP_017809010.1,-;XP_017809005.1,-;XP_017809006.1,-;XP_017809009.1,-;XP_017809008.1,-;XP_017809003.1,-;XP_017809007.1,-;XP_017809004.1,-;XP_003917185.1,zinc finger protein 821 isoform X1;XP_009195064.1,-","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["SYDE1",1.796671969,0.247916856,2.814699681,2.283157809,1.65623E-4,4.78009E-4,"ENSG00000105137","H2QFL6,Synapse defective 1, Rho GTPase, homolog 1","XP_003316210.1,rho GTPase-activating protein SYDE1","PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain","KOG1452,Predicted Rho GTPase-activating protein;ENOG410XYAD,-","GO:0005737,cellular_component,cytoplasm;GO:1901165,biological_process,positive regulation of trophoblast cell migration;GO:0051493,biological_process,regulation of cytoskeleton organization;GO:0007165,biological_process,signal transduction;GO:0043087,biological_process,regulation of GTPase activity","-"]
["ADM2",3.276461312,0.459770971,2.811651192,3.155714875,{"v":3.13e-07,"d":"3.13E-07"},{"v":1.64E-6,"d":"1.64E-06"},"ENSG00000128165","G1QIU5,Uncharacterized protein","-","-","-","-","-","-"]
["NHS",1.377866697,0.193349791,2.811651192,3.155714875,{"v":3.13e-07,"d":"3.13E-07"},{"v":1.64E-6,"d":"1.64E-06"},"ENSG00000188158","F7CLI9,NHS actin remodeling regulator","XP_001104388.1,Nance-Horan syndrome protein isoform X2","PF15273,NHS-like","IPR024845,Nance-Horan syndrome protein family","ENOG4111BJV,-;ENOG410IJ2I,-","GO:0030154,biological_process,cell differentiation;GO:0030054,cellular_component,cell junction;GO:0005794,cellular_component,Golgi apparatus;GO:0016604,cellular_component,nuclear body;GO:0002088,biological_process,lens development in camera-type eye","-"]
["HCG11",8.87630575,1.256217681,2.810084761,4.077706428,2.05E-11,{"v":2.76e-10,"d":"2.76E-10"},"ENSG00000228223","G2HGJ2,Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta","-","-","-","-","-","-"]
["CASD1",2.20746483,0.310817155,2.802517505,2.912597586,{"v":2.72e-06,"d":"2.72E-06"},{"v":1.17E-5,"d":"1.17E-05"},"ENSG00000127995","H2QUY3,CAS1 domain containing 1","XP_519208.3,CAS1 domain-containing protein 1 isoform X1","PF07779,10 TM Acyl Transferase domain found in Cas1p","IPR012419,Cas1p 10 TM acyl transferase domain;IPR036915,Cyclin-like superfamily","ENOG410XPE6,-;KOG1699,O-acetyltransferase","GO:0047186,molecular_function,N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity;GO:0005975,biological_process,carbohydrate metabolic process;GO:0030173,cellular_component,integral component of Golgi membrane","-"]
["MAML2",17.00199943,2.442841833,2.796626203,6.135085284,{"v":2.23e-23,"d":"2.23E-23"},{"v":3.05e-21,"d":"3.05E-21"},"ENSG00000184384","B7ZL21,MAML2 protein","-","PF09596,MamL-1 domain","IPR019082,Neurogenic mastermind-like, N-terminal","ENOG4111GMG,-;ENOG410ISMW,-","GO:0003713,molecular_function,transcription coactivator activity;GO:0007219,biological_process,Notch signaling pathway;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0016607,cellular_component,nuclear speck","-"]
["MEF2D",16.73351961,2.406278425,2.795108132,5.963605277,{"v":2.45e-22,"d":"2.45E-22"},2.99E-20,"ENSG00000116604","G3SH47,Myocyte enhancer factor 2D","XP_004027021.1,-;XP_018880146.1,-;XP_018880139.1,-","PF12347,Holliday junction regulator protein family C-terminal repeat;PF00319,SRF-type transcription factor (DNA-binding and dimerisation domain)","IPR002100,Transcription factor, MADS-box;IPR036879,Transcription factor, MADS-box superfamily;IPR033896,MADS MEF2-like;IPR022102,Holliday junction regulator protein family C-terminal","-","GO:0046983,molecular_function,protein dimerization activity;GO:0007512,biological_process,adult heart development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005634,cellular_component,nucleus;GO:0042826,molecular_function,histone deacetylase binding;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001958,biological_process,endochondral ossification;GO:0033613,molecular_function,activating transcription factor binding;GO:0003677,molecular_function,DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0002062,biological_process,chondrocyte differentiation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005654,cellular_component,nucleoplasm;GO:0019899,molecular_function,enzyme binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:1904707,biological_process,positive regulation of vascular smooth muscle cell proliferation;GO:0001649,biological_process,osteoblast differentiation","K09262,ko04022,cGMP-PKG signaling pathway"]
["PANX2",6.659907363,0.950667636,2.794149253,3.676707082,{"v":1.94e-09,"d":"1.94E-09"},{"v":1.67e-08,"d":"1.67E-08"},"ENSG00000073150","B3KTT7,Pannexin","NP_443071.2,pannexin-2 isoform 1","PF00876,Innexin","IPR000990,Innexin","ENOG410IGKS,-;ENOG4110P9D,-","GO:0030054,cellular_component,cell junction;GO:0005921,cellular_component,gap junction;GO:0006811,biological_process,ion transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["PPIP5K1",0.588136583,0.081155033,2.793964086,1.788991785,0.002426099,0.005369716,"ENSG00000168781","G3QPQ2,Diphosphoinositol pentakisphosphate kinase 1","-","PF00328,Histidine phosphatase superfamily (branch 2)","IPR037446,Histidine acid phosphatase, VIP1 family;IPR029033,Histidine phosphatase superfamily;IPR000560,Histidine phosphatase superfamily, clade-2;IPR033379,Histidine acid phosphatase active site","-","GO:0000829,molecular_function,inositol heptakisphosphate kinase activity;GO:0016310,biological_process,phosphorylation","-"]
["NR1D1",1.713276661,0.236409412,2.793964086,1.788991785,0.002426099,0.005369716,"ENSG00000126368","H2QCV8,Nuclear receptor subfamily 1, group D, member 1","XP_511468.2,-","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR001628,Zinc finger, nuclear hormone receptor-type;IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR013088,Zinc finger, NHR/GATA-type","ENOG410IMDK,-;ENOG410ZPPI,-","GO:0045598,biological_process,regulation of fat cell differentiation;GO:0061469,biological_process,regulation of type B pancreatic cell proliferation;GO:0005978,biological_process,glycogen biosynthetic process;GO:0010498,biological_process,proteasomal protein catabolic process;GO:0060086,biological_process,circadian temperature homeostasis;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0001046,molecular_function,core promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:2000188,-,-;GO:0043401,biological_process,steroid hormone mediated signaling pathway;GO:0010871,biological_process,negative regulation of receptor biosynthetic process;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0016604,cellular_component,nuclear body;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0001222,molecular_function,transcription corepressor binding;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0000790,cellular_component,nuclear chromatin;GO:0007623,biological_process,circadian rhythm;GO:0034144,biological_process,negative regulation of toll-like receptor 4 signaling pathway;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0030425,cellular_component,dendrite;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0035947,biological_process,regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter;GO:0019216,biological_process,regulation of lipid metabolic process;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0043197,cellular_component,dendritic spine;GO:0020037,molecular_function,heme binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0008270,molecular_function,zinc ion binding;GO:0032922,biological_process,circadian regulation of gene expression;GO:0070859,biological_process,positive regulation of bile acid biosynthetic process;GO:0046872,molecular_function,metal ion binding;GO:0061178,biological_process,regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042752,biological_process,regulation of circadian rhythm;GO:0044321,biological_process,response to leptin","K03728,ko04710,Circadian rhythm"]
["ZNF555",0.555007936,0.07658372,2.793964086,1.788991785,0.002426099,0.005369716,"ENSG00000186300","H2RGS4,Uncharacterized protein","XP_009432605.1,zinc finger protein 555 isoform X3","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["SLC3A1",0.726066795,0.100187569,2.793964086,1.788991785,0.002426099,0.005369716,"ENSG00000138079","A0A0S2Z4E1,Solute carrier family 3","NP_000332.2,neutral and basic amino acid transport protein rBAT","PF00128,Alpha amylase, catalytic domain","IPR017853,Glycoside hydrolase superfamily;IPR006047,Glycosyl hydrolase, family 13, catalytic domain","-","GO:0005975,biological_process,carbohydrate metabolic process;GO:0005774,cellular_component,vacuolar membrane;GO:0031526,cellular_component,brush border membrane;GO:0003824,molecular_function,catalytic activity;GO:0006865,biological_process,amino acid transport;GO:0005886,cellular_component,plasma membrane;GO:0046982,molecular_function,protein heterodimerization activity;GO:0016020,cellular_component,membrane;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","K14210,ko04974,Protein digestion and absorption"]
["HECW2",0.374188694,0.051633067,2.793964086,1.788991785,0.002426099,0.005369716,"ENSG00000138411","G1R542,HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2","XP_003253925.1,E3 ubiquitin-protein ligase HECW2 isoform X1","PF16562,N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2;PF00632,HECT-domain (ubiquitin-transferase);PF00168,C2 domain;PF00397,WW domain","IPR001202,WW domain;IPR037795,E3 ubiquitin-protein ligase HECW, C2 domain;IPR000569,HECT domain;IPR032348,E3 ubiquitin-protein ligase HECW1/2, N-terminal;IPR035892,C2 domain superfamily;IPR036020,WW domain superfamily;IPR035983,HECT, E3 ligase catalytic domain;IPR000008,C2 domain","KOG0940,Ubiquitin protein ligase RSP5/NEDD4;COG5021,Ubiquitin-protein ligase","GO:0072686,cellular_component,mitotic spindle;GO:0030071,biological_process,regulation of mitotic metaphase/anaphase transition;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016740,molecular_function,transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["AC096574.4",1.220874783,0.168464496,2.793964086,1.788991785,0.002426099,0.005369716,"ENSG00000225057","H2P931,Uncharacterized protein","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["RP11-517I3.1",2.811843047,0.387996975,2.793964086,1.788991785,0.002426099,0.005369716,"-","-","-","-","-","-","-","-"]
["KDELC2",1.854785833,0.262498254,2.788825988,2.61838026,{"v":4.17e-05,"d":"4.17E-05"},1.37892E-4,"ENSG00000178202","A0A024R3C4,KDEL","NP_714916.3,KDEL motif-containing protein 2 precursor","PF00630,ilamin/ABP280 repeat;PF05686,lycosyl transferase family 90","IPR017868,Filamin/ABP280 repeat-like;IPR013783,Immunoglobulin-like fold;IPR001298,Filamin/ABP280 repeat;IPR006598,Lipopolysaccharide-modifying protein;IPR014756,Immunoglobulin E-set","KOG2458,Endoplasmic reticulum protein EP58, contains filamin rod domain and KDEL motif;ENOG410XT5U,-","-","-"]
["SP6",2.272624703,0.32163283,2.788825988,2.61838026,{"v":4.17e-05,"d":"4.17E-05"},1.37892E-4,"ENSG00000189120","G3QPF7,Sp6 transcription factor","-","PF00096,Zinc finger, C2H2 type","-","-","-","-"]
["HRK",2.009731275,0.286878837,2.787050097,3.135669081,{"v":3.13e-07,"d":"3.13E-07"},{"v":1.64E-6,"d":"1.64E-06"},"ENSG00000135116","U3E722,Activator of apoptosis harakiri","-","PF15196,Activator of apoptosis harakiri","IPR020728,Apoptosis regulator, Bcl-2, BH3 motif, conserved site;IPR017249,Activator of apoptosis harakiri","-","GO:0042981,biological_process,regulation of apoptotic process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MEMO1",3.502764595,0.502166199,2.786149809,3.513169623,{"v":1.71e-08,"d":"1.71E-08"},{"v":1.2e-07,"d":"1.20E-07"},"ENSG00000162959","F6Y3G0,Mediator of cell motility 1","-","PF01875,Memo-like protein","IPR002737,MEMO1 family","KOG3086,Predicted dioxygenase;COG1355,Predicted dioxygenase","-","-"]
["C11orf24",13.94363742,2.020238505,2.780855886,4.821558575,{"v":1.93e-15,"d":"1.93E-15"},{"v":6.5e-14,"d":"6.50E-14"},"ENSG00000171067","A0A024R5K9,Chromosome 11 open reading frame 24, isoform CRA_a","XP_005274110.1,-;NP_071733.1,uncharacterized protein C11orf24 isoform 1 precursor","-","-","ENOG410YWNI,-;ENOG410J32Q,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["FOXJ3",62.04348203,9.031779278,2.779516209,7.943486579,{"v":1.82e-31,"d":"1.82E-31"},{"v":5.22e-29,"d":"5.22E-29"},"ENSG00000198815","H2R952,Forkhead box J3","XP_009453673.1,forkhead box protein J3 isoform X3","PF00250,orkhead domain","IPR018122,Fork head domain conserved site1;IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily","KOG2294,Transcription factor of the Forkhead/HNF3 family;COG5025,Transcription factor of the Forkhead/HNF3 family","GO:0030154,biological_process,cell differentiation;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0009653,biological_process,anatomical structure morphogenesis;GO:0005634,cellular_component,nucleus","-"]
["RP1-68D18.4",50.1619387,7.256600998,2.779301735,4.160730887,{"v":8.56e-12,"d":"8.56E-12"},{"v":1.25e-10,"d":"1.25E-10"},"ENSG00000255443","A0A146USV1,Uncharacterized protein","-","PF14529,ndonuclease-reverse transcriptase","IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR005135,Endonuclease/exonuclease/phosphatase;IPR000477,Reverse transcriptase domain","-","-","-"]
["B3GAT2",3.110673647,0.449195888,2.777498415,3.662911622,{"v":2.76E-9,"d":"2.76E-09"},{"v":2.29E-8,"d":"2.29E-08"},"ENSG00000112309","Q599K0,Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase","NP_001032391.1,-","PF03360,lycosyltransferase family 43","IPR005027,Glycosyl transferase, family 43;IPR029044,Nucleotide-diphospho-sugar transferases","ENOG410XP79,-;KOG1476,Beta-1,3-glucuronyltransferase B3GAT1/SQV-8","GO:0005975,biological_process,carbohydrate metabolic process;GO:0015018,molecular_function,galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0006486,biological_process,protein glycosylation;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0030204,biological_process,chondroitin sulfate metabolic process;GO:0005794,cellular_component,Golgi apparatus;GO:0016021,cellular_component,integral component of membrane;GO:0050650,biological_process,chondroitin sulfate proteoglycan biosynthetic process","K10157,ko00514,Other types of O-glycan biosynthesis"]
["WAC",43.64216651,6.398416469,2.76939264,8.258115092,{"v":2.94e-32,"d":"2.94E-32"},{"v":9.27e-30,"d":"9.27E-30"},"ENSG00000095787","H9FVF8,WW domain containing adaptor with coiled-coil","XP_015002173.1,-","PF00397,WW domain","IPR001202,WW domain;IPR036020,WW domain superfamily","ENOG410ISFU,-;ENOG4111EBW,-","GO:0044783,biological_process,G1 DNA damage checkpoint;GO:0071894,biological_process,histone H2B conserved C-terminal lysine ubiquitination;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0000993,molecular_function,RNA polymerase II core binding;GO:0032435,biological_process,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0016239,biological_process,positive regulation of macroautophagy;GO:0010390,biological_process,histone monoubiquitination;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-658F2.8",2.944140322,0.420260939,2.766029274,2.245366418,0.000264517,0.000729292,"ENSG00000258297","G7P5T5,Uncharacterized protein","-","-","-","-","-","-"]
["NRSN2",2.34788415,0.335148427,2.766029274,2.245366418,0.000264517,0.000729292,"ENSG00000125841","G3QTK7,Neurensin 2","XP_004061677.1,neurensin-2;XP_018872700.1,-","PF14927,Neurensin","IPR024883,Neurensin;IPR029701,Neurensin-2","-","GO:0031410,cellular_component,cytoplasmic vesicle;GO:0043025,cellular_component,neuronal cell body;GO:0030133,cellular_component,transport vesicle;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ADNP-AS1",7.428634534,1.060399499,2.766029274,2.245366418,0.000264517,0.000729292,"-","-","-","-","-","-","-","-"]
["ZFHX4",0.438984141,0.062662736,2.766029274,2.245366418,0.000264517,0.000729292,"ENSG00000091656","G3SI49,Zinc finger homeobox 4","-","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type;PF00046,Homeobox domain","-","-","-","-"]
["BCL9",8.359188915,1.224910075,2.765311257,4.993957679,3.34E-16,{"v":1.33e-14,"d":"1.33E-14"},"ENSG00000116128","A0A024QYY4,B-cell CLL/lymphoma 9, isoform CRA_a","NP_004317.2,B-cell CLL/lymphoma 9 protein;XP_005273028.1,-","PF11502,B-cell lymphoma 9 protein","IPR015668,B Cell Lymphoma 9;IPR024670,B-cell lymphoma 9, beta-catenin binding domain","ENOG410XRMX,-;ENOG410IICK,-","GO:0005794,cellular_component,Golgi apparatus;GO:0005737,cellular_component,cytoplasm;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0003713,molecular_function,transcription coactivator activity;GO:0035019,biological_process,somatic stem cell population maintenance;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0008013,molecular_function,beta-catenin binding;GO:0014908,biological_process,myotube differentiation involved in skeletal muscle regeneration;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0005801,cellular_component,cis-Golgi network;GO:0005634,cellular_component,nucleus","-"]
["ARHGAP17",13.98945283,2.056395748,2.764066648,6.329604187,{"v":4.72e-24,"d":"4.72E-24"},7.37E-22,"ENSG00000140750","G3QM70,Rho GTPase activating protein 17","XP_004057420.1,rho GTPase-activating protein 17 isoform X1","PF03114,BAR domain;PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain;IPR027267,AH/BAR domain superfamily;IPR004148,BAR domain","-","GO:0005737,cellular_component,cytoplasm;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005886,cellular_component,plasma membrane;GO:0005096,molecular_function,GTPase activator activity;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction","-"]
["DENND4C",4.588995375,0.674435908,2.759266889,4.590019994,5.06E-14,{"v":1.22e-12,"d":"1.22E-12"},"ENSG00000137145","A0A0D9RAJ9,DENN domain containing 4C","XP_007967326.1,-;XP_007967324.1,DENN domain-containing protein 4C isoform X1;XP_007967325.1,-","PF02141,NN (AEX-3) domain;PF03455,dDENN domain;PF03456,uDENN domain","IPR023341,MABP domain;IPR005112,dDENN domain;IPR001194,cDENN domain;IPR037516,Tripartite DENN domain;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR005113,uDENN domain","-","GO:0030904,cellular_component,retromer complex;GO:0072659,biological_process,protein localization to plasma membrane;GO:0065009,biological_process,regulation of molecular function;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0017112,molecular_function,Rab guanyl-nucleotide exchange factor activity;GO:0032593,cellular_component,insulin-responsive compartment;GO:0032869,biological_process,cellular response to insulin stimulus","-"]
["OSR2",15.96575038,2.348441074,2.759067427,4.803074885,{"v":3.96e-15,"d":"3.96E-15"},1.24E-13,"ENSG00000164920","G3QV09,Odd-skipped related transciption factor 2","XP_004047410.1,protein odd-skipped-related 2 isoform X1","PF00096,Zinc finger, C2H2 type;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["TAB2",86.7658035,12.86665109,2.752943152,8.231701181,{"v":7.4E-32,"d":"7.40E-32"},{"v":2.25e-29,"d":"2.25E-29"},"ENSG00000055208","A0A0D9RXB3,TGF-beta activated kinase 1/MAP3K7 binding protein 2","XP_008004888.1,-;XP_008004889.1,-","PF02845,CUE domain","IPR003892,Ubiquitin system component Cue;IPR001876,Zinc finger, RanBP2-type;IPR036443,Zinc finger, RanBP2-type superfamily","-","GO:0007507,biological_process,heart development;GO:0070530,molecular_function,K63-linked polyubiquitin modification-dependent protein binding;GO:0045860,biological_process,positive regulation of protein kinase activity;GO:0046872,molecular_function,metal ion binding;GO:0005829,cellular_component,cytosol;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling","K04404,ko04620,Toll-like receptor signaling pathway;K04404,ko05140,Leishmaniasis;K04404,ko04668,TNF signaling pathway;K04404,ko05168,Herpes simplex infection;K04404,ko05169,Epstein-Barr virus infection;K04404,ko04621,NOD-like receptor signaling pathway;K04404,ko05145,Toxoplasmosis;K04404,ko04010,MAPK signaling pathway;K04404,ko04380,Osteoclast differentiation;K04404,ko04064,NF-kappa B signaling pathway;K04404,ko04013,MAPK signaling pathway - fly;K04404,ko04214,Apoptosis - fly;K04404,ko05162,Measles"]
["BMP2K",3.130134739,0.461590685,2.752349474,4.239204025,{"v":3.7E-12,"d":"3.70E-12"},{"v":5.87e-11,"d":"5.87E-11"},"ENSG00000138756","H2RA65,Uncharacterized protein","XP_526576.3,BMP-2-inducible protein kinase isoform X1","PF15282,BMP-2-inducible protein kinase C-terminus;PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain;IPR028182,BMP-2-inducible protein kinase, C-terminal;IPR008271,Serine/threonine-protein kinase, active site;IPR026105,BMP-2-inducible protein kinase","KOG1989,ARK protein kinase family;ENOG410Y515,-","GO:0045747,biological_process,positive regulation of Notch signaling pathway;GO:0005737,cellular_component,cytoplasm;GO:0030500,biological_process,regulation of bone mineralization;GO:0035612,molecular_function,AP-2 adaptor complex binding;GO:2000369,biological_process,regulation of clathrin-dependent endocytosis;GO:0005634,cellular_component,nucleus;GO:0050790,biological_process,regulation of catalytic activity;GO:0004672,molecular_function,protein kinase activity;GO:0016607,cellular_component,nuclear speck;GO:0019208,molecular_function,phosphatase regulator activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["DAGLA",1.567393698,0.227662633,2.751491861,2.58879074,{"v":6.4e-05,"d":"6.40E-05"},0.000202688,"ENSG00000134780","K6ZXB4,Diacylglycerol lipase, alpha","XP_016776509.1,-","PF01764,Lipase (class 3)","IPR002921,Fungal lipase-like domain;IPR029058,Alpha/Beta hydrolase fold","ENOG410XRFI,-;KOG2088,Predicted lipase/calmodulin-binding heat-shock protein","GO:0006629,biological_process,lipid metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0098921,biological_process,retrograde trans-synaptic signaling by endocannabinoid;GO:0042136,biological_process,neurotransmitter biosynthetic process;GO:0007216,biological_process,G-protein coupled glutamate receptor signaling pathway;GO:0019369,biological_process,arachidonic acid metabolic process;GO:0046340,biological_process,diacylglycerol catabolic process;GO:0007405,biological_process,neuroblast proliferation;GO:0071926,biological_process,endocannabinoid signaling pathway;GO:0045211,cellular_component,postsynaptic membrane;GO:0022008,biological_process,neurogenesis;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0043196,cellular_component,varicosity","-"]
["RP4-568C11.4",7.887662168,1.145676381,2.751491861,2.58879074,{"v":6.4e-05,"d":"6.40E-05"},0.000202688,"ENSG00000274173","Q7ZGS2,Env protein","-","-","IPR018154,TLV/ENV coat polyprotein","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MEX3C",7.395831286,1.094985447,2.750648476,5.038373971,1.99E-16,{"v":8.15e-15,"d":"8.15E-15"},"ENSG00000176624","A0A096N6D3,Mex-3 RNA binding family member C","XP_003914436.1,RNA-binding E3 ubiquitin-protein ligase MEX3C","PF13920,Zinc finger, C3HC4 type (RING finger);PF00013,KH domain","IPR004087,K Homology domain;IPR001841,Zinc finger, RING-type;IPR004088,K Homology domain, type 1;IPR036612,K Homology domain, type 1 superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type","-","GO:0003415,biological_process,chondrocyte hypertrophy;GO:0003676,molecular_function,nucleic acid binding;GO:0045598,biological_process,regulation of fat cell differentiation;GO:0097009,biological_process,energy homeostasis;GO:0003723,molecular_function,RNA binding","-"]
["GPR87",93.13807819,13.89385633,2.743134636,6.52421947,5.51E-25,1.01E-22,"ENSG00000138271","H2QNL3,Uncharacterized protein","XP_001144931.1,G-protein coupled receptor 87;XP_016797655.1,-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR017452,GPCR, rhodopsin-like, 7TM;IPR008109,P2Y13 purinoceptor;IPR000276,G protein-coupled receptor, rhodopsin-like","ENOG410IE7G,-;ENOG410YEMD,-","GO:0035589,biological_process,G-protein coupled purinergic nucleotide receptor signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0045028,molecular_function,G-protein coupled purinergic nucleotide receptor activity;GO:0016020,cellular_component,membrane;GO:0007194,biological_process,negative regulation of adenylate cyclase activity;GO:0004871,molecular_function,signal transducer activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0005887,cellular_component,integral component of plasma membrane;GO:0007165,biological_process,signal transduction","-"]
["PBX3",10.69593059,1.591652858,2.742616794,4.853693788,{"v":2.2e-15,"d":"2.20E-15"},{"v":7.29e-14,"d":"7.29E-14"},"ENSG00000167081","Q5JS98,Pre-B-cell leukemia transcription factor 3","XP_006717193.1,pre-B-cell leukemia transcription factor 3 isoform X1","PF03792,PBC domain;PF05920,Homeobox KN domain","IPR008422,Homeobox KN domain;IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR005542,PBX","ENOG410XRVF,-;KOG0774,Transcription factor PBX and related HOX domain proteins","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005515,molecular_function,protein binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["S100A12",21.54561164,3.162774566,2.742577574,2.864384536,{"v":6.24e-06,"d":"6.24E-06"},{"v":2.48E-5,"d":"2.48E-05"},"ENSG00000163221","G3QV32,S100 calcium binding protein A12","XP_004026774.1,protein S100-A12","PF01023,S-100/ICaBP type calcium binding domain","IPR002048,EF-hand domain;IPR011992,EF-hand domain pair;IPR013787,S100/CaBP-9k-type, calcium binding, subdomain;IPR001751,S100/Calbindin-D9k, conserved site","-","GO:0031640,biological_process,killing of cells of other organism;GO:0005737,cellular_component,cytoplasm;GO:0050832,biological_process,defense response to fungus;GO:0046872,molecular_function,metal ion binding;GO:0050786,molecular_function,RAGE receptor binding;GO:0061844,biological_process,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006805,biological_process,xenobiotic metabolic process;GO:0005509,molecular_function,calcium ion binding;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0005634,cellular_component,nucleus","-"]
["HMCN1",0.600711924,0.088181131,2.742577574,2.864384536,{"v":6.24e-06,"d":"6.24E-06"},{"v":2.48E-5,"d":"2.48E-05"},"ENSG00000143341","K7CJZ0,Hemicentin 1","-","PF12662,Complement Clr-like EGF-like;PF07679,Immunoglobulin I-set domain;PF13927,Immunoglobulin domain;PF00090,Thrombospondin type 1 domain;PF07645,Calcium-binding EGF domain;PF07474,2F domain","IPR003599,Immunoglobulin subtype;IPR013106,Immunoglobulin V-set domain;IPR018097,EGF-like calcium-binding, conserved site;IPR036465,von Willebrand factor A-like domain superfamily;IPR006605,G2 nidogen/fibulin G2F;IPR009017,Green fluorescent protein;IPR007110,Immunoglobulin-like domain;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR001881,EGF-like calcium-binding domain;IPR036179,Immunoglobulin-like domain superfamily;IPR026823,Complement Clr-like EGF domain;IPR013783,Immunoglobulin-like fold;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","ENOG410XQFD,-;ENOG410IUGC,-","GO:0005509,molecular_function,calcium ion binding","-"]
["BCL2",0.948629565,0.139253483,2.742577574,2.864384536,{"v":6.24e-06,"d":"6.24E-06"},{"v":2.48E-5,"d":"2.48E-05"},"ENSG00000171791","H2QEM8,B-cell CLL/lymphoma 2","XP_001145537.1,-","PF00452,Apoptosis regulator proteins, Bcl-2 family;PF02180,Bcl-2 homology region 4","IPR020717,Apoptosis regulator, Bcl-2, BH1 motif, conserved site;IPR020731,Apoptosis regulator, Bcl-2, BH4 motif, conserved site;IPR026298,Blc2 family;IPR003093,Apoptosis regulator, Bcl-2 protein, BH4;IPR020728,Apoptosis regulator, Bcl-2, BH3 motif, conserved site;IPR020726,Apoptosis regulator, Bcl-2, BH2 motif, conserved site;IPR002475,Bcl2-like;IPR013278,Apoptosis regulator, Bcl-2;IPR036834,Blc2-like superfamily;IPR004725,Apoptosis regulator, Bcl-2/ BclX","ENOG41123S0,-;KOG4728,Anti-apoptotic Bcl-2 family proteins, prevent opening of mitochondrial porin channel","GO:0031103,biological_process,axon regeneration;GO:0051607,biological_process,defense response to virus;GO:0014031,biological_process,mesenchymal cell development;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:2000134,biological_process,negative regulation of G1/S transition of mitotic cell cycle;GO:0050790,biological_process,regulation of catalytic activity;GO:0046982,molecular_function,protein heterodimerization activity;GO:0032469,biological_process,endoplasmic reticulum calcium ion homeostasis;GO:0010507,biological_process,negative regulation of autophagy;GO:0005634,cellular_component,nucleus;GO:0030336,biological_process,negative regulation of cell migration;GO:0043496,biological_process,regulation of protein homodimerization activity;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0048546,biological_process,digestive tract morphogenesis;GO:0001657,biological_process,ureteric bud development;GO:0008637,biological_process,apoptotic mitochondrial changes;GO:0051721,molecular_function,protein phosphatase 2A binding;GO:0048743,biological_process,positive regulation of skeletal muscle fiber development;GO:0001822,biological_process,kidney development;GO:0042149,biological_process,cellular response to glucose starvation;GO:0050853,biological_process,B cell receptor signaling pathway;GO:0030097,biological_process,hemopoiesis;GO:0040018,biological_process,positive regulation of multicellular organism growth;GO:0010559,biological_process,regulation of glycoprotein biosynthetic process;GO:0031966,cellular_component,mitochondrial membrane;GO:0010224,biological_process,response to UV-B;GO:0014042,biological_process,positive regulation of neuron maturation;GO:0048070,biological_process,regulation of developmental pigmentation;GO:2000378,biological_process,negative regulation of reactive oxygen species metabolic process;GO:0043029,biological_process,T cell homeostasis;GO:0001503,biological_process,ossification;GO:0048599,biological_process,oocyte development;GO:0002931,biological_process,response to ischemia;GO:0031069,biological_process,hair follicle morphogenesis;GO:0048538,biological_process,thymus development;GO:0070059,biological_process,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0048536,biological_process,spleen development;GO:0018107,biological_process,peptidyl-threonine phosphorylation;GO:0048545,biological_process,response to steroid hormone;GO:0010332,biological_process,response to gamma radiation;GO:0051434,molecular_function,BH3 domain binding;GO:0001541,biological_process,ovarian follicle development;GO:0007409,biological_process,axonogenesis;GO:0040007,biological_process,growth;GO:0032991,cellular_component,protein-containing complex;GO:0098609,biological_process,cell-cell adhesion;GO:0045069,biological_process,regulation of viral genome replication;GO:0030217,biological_process,T cell differentiation;GO:0005783,cellular_component,endoplasmic reticulum;GO:0008134,molecular_function,transcription factor binding;GO:0007569,biological_process,cell aging;GO:0009887,biological_process,animal organ morphogenesis;GO:2000811,biological_process,negative regulation of anoikis;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0051881,biological_process,regulation of mitochondrial membrane potential;GO:0002260,biological_process,lymphocyte homeostasis;GO:0001662,biological_process,behavioral fear response;GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0071310,biological_process,cellular response to organic substance;GO:0006808,biological_process,regulation of nitrogen utilization;GO:0046930,cellular_component,pore complex;GO:0005739,cellular_component,mitochondrion;GO:0042493,biological_process,response to drug;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0003014,biological_process,renal system process;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0048589,biological_process,developmental growth;GO:0043375,biological_process,CD8-positive, alpha-beta T cell lineage commitment;GO:0010468,biological_process,regulation of gene expression;GO:0071456,biological_process,cellular response to hypoxia;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0005622,cellular_component,intracellular;GO:0051726,biological_process,regulation of cell cycle;GO:0032848,biological_process,negative regulation of cellular pH reduction;GO:0000209,biological_process,protein polyubiquitination;GO:0043473,biological_process,pigmentation;GO:0045930,biological_process,negative regulation of mitotic cell cycle;GO:2001234,biological_process,negative regulation of apoptotic signaling pathway;GO:0035265,biological_process,organ growth;GO:0043067,biological_process,regulation of programmed cell death;GO:0034097,biological_process,response to cytokine;GO:0010506,biological_process,regulation of autophagy;GO:0046671,biological_process,negative regulation of retinal cell programmed cell death;GO:0045636,biological_process,positive regulation of melanocyte differentiation;GO:0042803,molecular_function,protein homodimerization activity;GO:0032835,biological_process,glomerulus development;GO:0010523,biological_process,negative regulation of calcium ion transport into cytosol;GO:0006470,biological_process,protein dephosphorylation;GO:0008584,biological_process,male gonad development;GO:0048087,biological_process,positive regulation of developmental pigmentation;GO:0035094,biological_process,response to nicotine;GO:0001836,biological_process,release of cytochrome c from mitochondria;GO:0030318,biological_process,melanocyte differentiation;GO:0022612,biological_process,gland morphogenesis;GO:0001656,biological_process,metanephros development;GO:0030307,biological_process,positive regulation of cell growth;GO:0051402,biological_process,neuron apoptotic process;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0043085,biological_process,positive regulation of catalytic activity;GO:0048873,biological_process,homeostasis of number of cells within a tissue;GO:0019903,molecular_function,protein phosphatase binding;GO:0006979,biological_process,response to oxidative stress;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol;GO:0048041,biological_process,focal adhesion assembly;GO:0072593,biological_process,reactive oxygen species metabolic process;GO:0032880,biological_process,regulation of protein localization;GO:0048066,biological_process,developmental pigmentation;GO:0030183,biological_process,B cell differentiation;GO:0001952,biological_process,regulation of cell-matrix adhesion;GO:0002320,biological_process,lymphoid progenitor cell differentiation;GO:0033689,biological_process,negative regulation of osteoblast proliferation;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0002520,biological_process,immune system development;GO:0033033,biological_process,negative regulation of myeloid cell apoptotic process;GO:0016021,cellular_component,integral component of membrane;GO:0001782,biological_process,B cell homeostasis;GO:0051924,biological_process,regulation of calcium ion transport;GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0002360,biological_process,T cell lineage commitment;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0006915,biological_process,apoptotic process;GO:0001776,biological_process,leukocyte homeostasis;GO:0030308,biological_process,negative regulation of cell growth;GO:0008631,biological_process,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0000902,biological_process,cell morphogenesis;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0048753,biological_process,pigment granule organization;GO:0002020,molecular_function,protease binding;GO:0051384,biological_process,response to glucocorticoid;GO:0042981,biological_process,regulation of apoptotic process;GO:0042542,biological_process,response to hydrogen peroxide;GO:0046902,biological_process,regulation of mitochondrial membrane permeability;GO:0009636,biological_process,response to toxic substance;GO:0031647,biological_process,regulation of protein stability;GO:0001658,biological_process,branching involved in ureteric bud morphogenesis;GO:0042802,molecular_function,identical protein binding;GO:0021747,biological_process,cochlear nucleus development;GO:0002326,biological_process,B cell lineage commitment;GO:0030279,biological_process,negative regulation of ossification;GO:0042100,biological_process,B cell proliferation;GO:0010039,biological_process,response to iron ion;GO:0033077,biological_process,T cell differentiation in thymus;GO:0016020,cellular_component,membrane;GO:0009791,biological_process,post-embryonic development;GO:2001240,biological_process,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0005654,cellular_component,nucleoplasm;GO:0043209,cellular_component,myelin sheath;GO:0015267,molecular_function,channel activity;GO:0055085,biological_process,transmembrane transport;GO:0008283,biological_process,cell proliferation;GO:0008625,biological_process,extrinsic apoptotic signaling pathway via death domain receptors;GO:0016248,molecular_function,channel inhibitor activity;GO:0030890,biological_process,positive regulation of B cell proliferation;GO:0022898,biological_process,regulation of transmembrane transporter activity;GO:2001243,biological_process,negative regulation of intrinsic apoptotic signaling pathway;GO:0043583,biological_process,ear development;GO:0007015,biological_process,actin filament organization;GO:0014911,biological_process,positive regulation of smooth muscle cell migration;GO:0043497,biological_process,regulation of protein heterodimerization activity;GO:0006582,biological_process,melanin metabolic process","K02161,ko05222,Small cell lung cancer;K02161,ko05210,Colorectal cancer;K02161,ko04141,Protein processing in endoplasmic reticulum;K02161,ko01524,Platinum drug resistance;K02161,ko04725,Cholinergic synapse;K02161,ko05169,Epstein-Barr virus infection;K02161,ko01521,EGFR tyrosine kinase inhibitor resistance;K02161,ko04210,Apoptosis;K02161,ko04933,AGE-RAGE signaling pathway in diabetic complications;K02161,ko05206,MicroRNAs in cancer;K02161,ko05215,Prostate cancer;K02161,ko05145,Toxoplasmosis;K02161,ko04066,HIF-1 signaling pathway;K02161,ko04071,Sphingolipid signaling pathway;K02161,ko04722,Neurotrophin signaling pathway;K02161,ko05161,Hepatitis B;K02161,ko04064,NF-kappa B signaling pathway;K02161,ko04215,Apoptosis - multiple species;K02161,ko05200,Pathways in cancer;K02161,ko04261,Adrenergic signaling in cardiomyocytes;K02161,ko04151,PI3K-Akt signaling pathway;K02161,ko01522,Endocrine resistance;K02161,ko04510,Focal adhesion;K02161,ko04340,Hedgehog signaling pathway;K02161,ko05152,Tuberculosis;K02161,ko04630,Jak-STAT signaling pathway;K02161,ko05014,Amyotrophic lateral sclerosis (ALS)"]
["PRDM4",15.60864258,2.332124164,2.738843869,5.458728205,{"v":7.42e-19,"d":"7.42E-19"},{"v":4.83e-17,"d":"4.83E-17"},"ENSG00000110851","K7CXK8,PR domain zinc finger protein 4","XP_001162965.1,PR domain zinc finger protein 4 isoform X2","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR001214,SET domain;IPR036236,Zinc finger C2H2 superfamily;IPR017124,PR-domain zinc finger protein PRDM4","KOG1721,FOG: Zn-finger;KOG2461,Transcription factor BLIMP-1/PRDI-BF1, contains C2H2-type Zn-finger and SET domains;COG5048,FOG: Zn-finger","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0035097,cellular_component,histone methyltransferase complex;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:1990226,molecular_function,histone methyltransferase binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","K12463,ko04722,Neurotrophin signaling pathway"]
["HIVEP3",7.549021358,1.129238206,2.738312778,5.973735552,{"v":7.24e-22,"d":"7.24E-22"},{"v":8.15e-20,"d":"8.15E-20"},"ENSG00000127124","H2R953,Human immunodeficiency virus type I enhancer binding protein 3","XP_001172796.1,transcription factor HIVEP3 isoform X2;XP_016815789.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR034729,Zinc finger CCHC HIVEP-type","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0007275,biological_process,multicellular organism development;GO:0007165,biological_process,signal transduction","-"]
["FOXD2-AS1",0.946433421,0.130595235,2.734051931,1.015902743,0.024634949,0.042100689,"-","-","-","-","-","-","-","-"]
["NBPF19",0.126409447,0.017442824,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000271383","H7BY70,Neuroblastoma breakpoint family member 20","-","PF06758,Repeat of unknown function (DUF1220)","IPR010630,Neuroblastoma breakpoint family (NBPF) domain","ENOG410KG3F,-;ENOG4110SQ7,-","-","-"]
["ALG1L9P",0.57790252,0.079742868,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000254978","B4DGH2,cDNA FLJ56781","-","-","-","-","-","-"]
["PIWIL4",0.52097443,0.071887548,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000134627","A0A140VKG8,Piwi-like 4","NP_689644.2,piwi-like protein 4","PF02170,PAZ domain;PF02171,Piwi domain","IPR036397,Ribonuclease H superfamily;IPR036085,PAZ domain superfamily;IPR003100,PAZ domain;IPR003165,Piwi domain;IPR012337,Ribonuclease H-like superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0031047,biological_process,gene silencing by RNA","K02156,ko04320,Dorso-ventral axis formation"]
["NDUFA4L2",0.846258536,0.116772432,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000185633","G3V560,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2","-","PF06522,NADH-ubiquinone reductase complex 1 MLRQ subunit","IPR010530,NADH-ubiquinone reductase complex 1 MLRQ subunit","ENOG410J463,-;ENOG410XWHY,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["EFS",0.733580925,0.101224419,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000100842","H2Q807,Embryonal Fyn-associated substrate","XP_509854.2,embryonal Fyn-associated substrate isoform X1","PF14604,Variant SH3 domain;PF12026,omain of unknown function (DUF3513)","IPR035747,Embryonal Fyn-associated substrate, SH3 domain;IPR021901,CAS family, C-terminal;IPR036028,SH3-like domain superfamily;IPR037362,CAS family;IPR001452,SH3 domain","ENOG410IEDN,-;ENOG410YE49,-","GO:0019904,molecular_function,protein domain specific binding;GO:0017124,molecular_function,SH3 domain binding","-"]
["PGBD4",0.359135126,0.049555875,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000182405","K7DKZ9,PiggyBac transposable element derived 4","XP_016783387.1,piggyBac transposable element-derived protein 4","PF13842,_Tnp_1-like zinc-ribbon;PF13843,Transposase IS4","IPR032718,PiggyBac transposable element-derived protein 4, C-terminal zinc-ribbon;IPR029526,PiggyBac transposable element-derived protein","-","-","-"]
["C15orf65",2.816846326,0.388687361,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000261652","K7BYQ4,Putative LOC145788","XP_003314728.1,uncharacterized protein C15orf65 homolog isoform X2","PF14892,omain of unknown function (DUF4490)","IPR026507,Uncharacterised protein family UPF0691","-","-","-"]
["SCIMP",0.564306429,0.077866788,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000161929","H2QC00,SLP adaptor and CSK interacting membrane protein","-","PF15050,SCIMP protein","IPR028181,SLP adapter and CSK-interacting membrane protein","ENOG41114KD,-;ENOG410J1IN,-","GO:0097197,cellular_component,tetraspanin-enriched microdomain;GO:0007127,biological_process,meiosis I;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0001772,cellular_component,immunological synapse;GO:0031256,cellular_component,leading edge membrane;GO:0031259,cellular_component,uropod membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["RP11-609D21.3",0.722641952,0.099714986,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000279296","A0A0V0V388,LINE-1 reverse transcriptase-like protein","-","PF03372,ndonuclease/Exonuclease/phosphatase family;PF08333,Protein of unknown function (DUF1725);PF00078,Reverse transcriptase (RNA-dependent DNA polymerase)","IPR013544,Domain of unknown function DUF1725;IPR005135,Endonuclease/exonuclease/phosphatase;IPR000477,Reverse transcriptase domain;IPR036691,Endonuclease/exonuclease/phosphatase superfamily","-","GO:0003964,molecular_function,RNA-directed DNA polymerase activity;GO:0006278,biological_process,RNA-dependent DNA biosynthetic process","-"]
["RP11-815I9.4",1.295472697,0.178758017,2.734051931,1.015902743,0.024634949,0.042100689,"-","-","-","-","-","-","-","-"]
["ASB16",1.064843701,0.14693428,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000161664","H2QD65,Uncharacterized protein","XP_511545.2,ankyrin repeat and SOCS box protein 16 isoform X1","PF12796,Ankyrin repeats (3 copies);PF07525,SOCS box","IPR020683,Ankyrin repeat-containing domain;IPR036036,SOCS box-like domain superfamily;IPR002110,Ankyrin repeat;IPR001496,SOCS box domain;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0035556,biological_process,intracellular signal transduction;GO:0000151,cellular_component,ubiquitin ligase complex;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0005634,cellular_component,nucleus","-"]
["RP11-839G9.1",4.188009617,0.577889674,2.734051931,1.015902743,0.024634949,0.042100689,"-","-","-","-","-","-","-","-"]
["KLHL26",0.495018022,0.068305909,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000167487","G3RUT6,Kelch like family member 26","XP_004060394.1,-","PF01344,Kelch motif;PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch","IPR011705,BTB/Kelch-associated;IPR011333,SKP1/BTB/POZ domain superfamily;IPR030588,Kelch-like protein 26;IPR015915,Kelch-type beta propeller;IPR017096,BTB-kelch protein;IPR006652,Kelch repeat type 1;IPR000210,BTB/POZ domain","-","-","-"]
["ZNF613",0.615979625,0.084997003,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000176024","H2NZX5,Zinc finger protein 613","XP_009231277.1,-;XP_009231276.1,zinc finger protein 613 isoform X1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF784",1.153839384,0.159214502,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000179922","H2R3A0,Zinc finger protein 784","XP_009434734.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0003676,molecular_function,nucleic acid binding","-"]
["AC125232.1",1.686506714,0.232715515,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000231259","G1QLA6,Anaphase promoting complex subunit 1","-","-","IPR024990,Anaphase-promoting complex subunit 1","KOG1858,Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24);ENOG410XQ83,-","GO:0070979,biological_process,protein K11-linked ubiquitination;GO:0005680,cellular_component,anaphase-promoting complex","K03348,ko04111,Cell cycle - yeast;K03348,ko04120,Ubiquitin mediated proteolysis;K03348,ko04914,Progesterone-mediated oocyte maturation;K03348,ko04114,Oocyte meiosis;K03348,ko05166,HTLV-I infection;K03348,ko04110,Cell cycle;K03348,ko04113,Meiosis - yeast"]
["CCDC74A",0.771726179,0.106487957,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000163040","K7BLB7,Coiled-coil domain containing 74B","XP_009441602.2,coiled-coil domain-containing protein 74B isoform X2","PF14917,Coiled coil protein 74, C terminal;PF14916,Coiled-coil domain of unknown function","IPR033226,Coiled-coil domain-containing protein 74;IPR029422,Coiled coil protein 74, C-terminal","ENOG4112DFU,-;ENOG410J255,-","-","-"]
["DHRS9",0.633227054,0.087376919,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000073737","H2QIX9,Uncharacterized protein","XP_003309347.2,dehydrogenase/reductase SDR family member 9 isoform X2","PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily;IPR002347,Short-chain dehydrogenase/reductase SDR","ENOG410Y7FK,-;KOG1610,Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases","GO:0004745,molecular_function,retinol dehydrogenase activity;GO:0004022,molecular_function,alcohol dehydrogenase (NAD) activity;GO:0008209,biological_process,androgen metabolic process;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0042448,biological_process,progesterone metabolic process;GO:0047035,molecular_function,testosterone dehydrogenase (NAD+) activity;GO:0042904,biological_process,9-cis-retinoic acid biosynthetic process","-"]
["BHLHE40-AS1",0.873979188,0.120597514,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000235831","H2PFT0,Uncharacterized protein","-","-","-","ENOG410IUV6,-;ENOG4110PU0,-","-","-"]
["KIF9-AS1",0.484810423,0.066897396,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000227398","H2PAW8,Kinesin-like protein","-","PF00225,Kinesin motor domain","IPR027640,Kinesin-like protein;IPR019821,Kinesin motor domain, conserved site;IPR001752,Kinesin motor domain;IPR036961,Kinesin motor domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG5059,Kinesin-like protein;KOG4280,Kinesin-like protein","GO:0002102,cellular_component,podosome;GO:1903008,biological_process,organelle disassembly;GO:0022617,biological_process,extracellular matrix disassembly;GO:0031982,cellular_component,vesicle;GO:0003777,molecular_function,microtubule motor activity;GO:0046983,molecular_function,protein dimerization activity;GO:0003774,molecular_function,motor activity;GO:0005874,cellular_component,microtubule;GO:0008017,molecular_function,microtubule binding;GO:0071801,biological_process,regulation of podosome assembly;GO:0007018,biological_process,microtubule-based movement;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["ERICH6-AS1",2.871343957,0.39620731,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000240137","D3DNJ2,HCG1811296, isoform CRA_a","-","-","-","-","-","-"]
["BCHE",0.77047419,0.1063152,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000114200","D3DNN4,Carboxylic ester hydrolase","XP_016862456.1,cholinesterase isoform X1","PF08674,Acetylcholinesterase tetramerisation domain;PF07859,alpha/beta hydrolase fold;PF00135,Carboxylesterase family","IPR014788,Acetylcholinesterase, tetramerisation domain;IPR019819,Carboxylesterase type B, conserved site;IPR019826,Carboxylesterase type B, active site;IPR002018,Carboxylesterase, type B;IPR000997,Cholinesterase;IPR029058,Alpha/Beta hydrolase fold","COG2272,Carboxylesterase type B;KOG4389,Acetylcholinesterase/Butyrylcholinesterase","GO:0016787,molecular_function,hydrolase activity;GO:0004104,molecular_function,cholinesterase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NUDT6",0.360279389,0.049713768,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000170917","H2QQ48,Uncharacterized protein","XP_517426.2,nucleoside diphosphate-linked moiety X motif 6 isoform X1","PF00293,NUDIX domain","IPR015797,NUDIX hydrolase-like domain superfamily;IPR003293,Nudix hydrolase 6-like;IPR000086,NUDIX hydrolase domain;IPR020084,NUDIX hydrolase, conserved site","KOG0648,Predicted NUDIX hydrolase FGF-2 and related proteins;ENOG410Z4GH,-","GO:0016787,molecular_function,hydrolase activity","-"]
["RP1-313I6.12",3.461518153,0.477643506,2.734051931,1.015902743,0.024634949,0.042100689,"-","-","-","-","-","-","-","-"]
["AL354822.1",0.784473556,0.108246926,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000278384","Q6ZW97,Hypothetical LOC389834","-","-","-","-","-","-"]
["AC007325.2",0.987360271,0.136242597,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000277196","A0A087WWM6,Proline dehydrogenase","-","PF01619,Proline dehydrogenase","IPR002872,Proline dehydrogenase domain;IPR029041,FAD-linked oxidoreductase-like;IPR015659,Proline oxidase family","COG0506,Proline dehydrogenase;KOG0186,Proline oxidase","GO:0006560,biological_process,proline metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0006562,biological_process,proline catabolic process;GO:0004657,molecular_function,proline dehydrogenase activity","-"]
["ZXDA",0.577340494,0.079665316,2.734051931,1.015902743,0.024634949,0.042100689,"ENSG00000198205","A8K9H1,cDNA FLJ76957, highly similar to Homo sapiens zinc finger, X-linked, duplicated A","-","PF00096,Zinc finger, C2H2 type;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["SLAIN2",11.72013593,1.7578511,2.733430252,5.494848591,{"v":4.3e-19,"d":"4.30E-19"},{"v":2.94e-17,"d":"2.94E-17"},"ENSG00000109171","A0A024R9T6,HCG17415, isoform CRA_a","NP_065897.1,SLAIN motif-containing protein 2","PF15301,SLAIN motif-containing family","IPR026179,SLAIN motif-containing protein","ENOG410IF0R,-;ENOG410XPVV,-","GO:0031122,biological_process,cytoplasmic microtubule organization;GO:0005813,cellular_component,centrosome;GO:0005829,cellular_component,cytosol;GO:0031113,biological_process,regulation of microtubule polymerization","-"]
["KCTD1",5.896446253,0.884381768,2.730682837,4.711471151,2.49E-14,{"v":6.44e-13,"d":"6.44E-13"},"ENSG00000134504","A0A250XXD6,BTB/POZ domain-containing protein KCTD1","XP_020033852.1,-","-","IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily;IPR003131,Potassium channel tetramerisation-type BTB domain","-","GO:0051260,biological_process,protein homooligomerization","-"]
["TFAP2A",16.90589512,2.543415462,2.730677509,6.345970119,{"v":8.57e-24,"d":"8.57E-24"},{"v":1.28e-21,"d":"1.28E-21"},"ENSG00000137203","A0A1D5QZG4,Transcription factor AP-2 alpha","XP_001089006.3,-","-","IPR004979,Transcription factor AP-2;IPR008121,Transcription factor AP-2 alpha, N-terminal;IPR013854,Transcription factor AP-2, C-terminal","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0005634,cellular_component,nucleus","-"]
["MTF1",8.641371189,1.30673358,2.72128297,5.358645217,{"v":5.88e-18,"d":"5.88E-18"},{"v":3.27e-16,"d":"3.27E-16"},"ENSG00000188786","H2R0J1,Metal-regulatory transcription factor 1","XP_016806861.1,-;XP_016806813.1,-;XP_009451322.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR029796,Metal regulatory transcription factor 1","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0035035,molecular_function,histone acetyltransferase binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0046686,biological_process,response to cadmium ion;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006979,biological_process,response to oxidative stress;GO:0001047,molecular_function,core promoter binding;GO:0005654,cellular_component,nucleoplasm","-"]
["UBAP2L",156.6926802,23.75701908,2.721275733,9.405492261,1.27E-33,{"v":4.17e-31,"d":"4.17E-31"},"ENSG00000143569","H2R3M4,Ubiquitin associated protein 2-like","XP_016783373.1,-","PF12478,Ubiquitin-associated protein 2","IPR015940,Ubiquitin-associated domain;IPR009060,UBA-like superfamily;IPR022166,Protein of unknown function DUF3697, ubiquitin-associated protein 2","ENOG410IGWX,-;ENOG4110RI8,-","GO:0005737,cellular_component,cytoplasm;GO:0061484,biological_process,hematopoietic stem cell homeostasis;GO:0010628,biological_process,positive regulation of gene expression;GO:0005634,cellular_component,nucleus","-"]
["NKRF",6.523630365,0.982008327,2.721193352,4.003457384,1.34E-10,{"v":1.48e-09,"d":"1.48E-09"},"ENSG00000186416","H2QZ19,Uncharacterized protein","XP_009437843.1,-","PF01424,R3H domain;PF01585,-patch domain","IPR000467,G-patch domain;IPR001374,R3H domain;IPR034071,NF-kappaB-repression factor, R3H domain;IPR014720,Double-stranded RNA-binding domain;IPR036867,R3H domain superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["RP11-574K11.5",10.13874778,1.472644697,2.720509761,1.734638437,0.003944816,0.008320304,"-","-","-","-","-","-","-","-"]
["RP11-96C23.13",0.989417272,0.143712037,2.720509761,1.734638437,0.003944816,0.008320304,"ENSG00000151303","G3S3H7,Uncharacterized protein","-","PF12796,Ankyrin repeats (3 copies);PF01412,Putative GTPase activating protein for Arf","-","-","-","-"]
["LMF1",0.548007137,0.079597582,2.720509761,1.734638437,0.003944816,0.008320304,"ENSG00000103227","K6Z8U7,Lipase maturation factor","-","PF06762,Lipase maturation factor","IPR009613,Lipase maturation factor","ENOG410XPYW,-;ENOG410IHGU,-","GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane","-"]
["CTD-3203P2.3",6.310129735,0.916541105,2.720509761,1.734638437,0.003944816,0.008320304,"-","-","-","-","-","-","-","-"]
["TUG1_2",51.85911219,7.53249299,2.720509761,1.734638437,0.003944816,0.008320304,"-","-","-","-","-","-","-","-"]
["PHTF1",0.927319954,0.137097676,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000116793","H2PZP5,Putative homeodomain transcription factor 1","XP_001154352.1,putative homeodomain transcription factor 1 isoform X1;XP_009427177.1,-;XP_009427168.1,-;XP_016780845.1,-","PF12129,Male germ-cell putative homeodomain transcription factor","IPR021980,Transcription factor homeodomain, male germ-cell","ENOG410ZM0V,-;ENOG410IF1F,-","GO:0003677,molecular_function,DNA binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RBM20",0.814614564,0.120434983,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000203867","H2R7D9,Uncharacterized protein","XP_508032.3,RNA-binding protein 20","-","IPR000690,Matrin/U1-C, C2H2-type zinc finger;IPR003604,Matrin/U1-C-like, C2H2-type zinc finger;IPR034791,RNA-binding protein 20;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034790,RBM20, RNA recognition motif;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily","ENOG410ZE4G,-;ENOG410IGBX,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0043484,biological_process,regulation of RNA splicing;GO:0008270,molecular_function,zinc ion binding;GO:0005634,cellular_component,nucleus","-"]
["C11orf71",2.965603955,0.438443504,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000282682","H2Q4T4,Chromosome 11 open reading frame 71","-","PF15747,omain of unknown function (DUF4687)","IPR031487,Protein of unknown function DUF4687","ENOG4111CNR,-;ENOG410J0JN,-","-","-"]
["LINC01296",1.028443011,0.152048002,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000244306","G7PZ30,Uncharacterized protein","-","PF00046,Homeobox domain","IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR000047,Helix-turn-helix motif","-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["AC093838.4",1.698744013,0.25114725,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000152117","H7BXF4,Sphingomyelin phosphodiesterase 4","NP_060221.2,sphingomyelin phosphodiesterase 4 isoform 1","PF14724,Mitochondrial-associated sphingomyelin phosphodiesterase","IPR024129,Sphingomyelin phosphodiesterase 4","KOG4396,Predicted membrane-anchored protein;ENOG410YYEJ,-","GO:0050290,molecular_function,sphingomyelin phosphodiesterase D activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K12353,ko00600,Sphingolipid metabolism"]
["DOCK10",0.600893273,0.088837807,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000135905","H2QJJ2,Dedicator of cytokinesis 10","XP_003309526.1,dedicator of cytokinesis protein 10 isoform X9","PF06920,ock homology region 2;PF14429,C2 domain in Dock180 and Zizimin proteins;PF11878,omain of unknown function (DUF3398);PF00169,PH domain","IPR037809,Dedicator of cytokinesis D, C2 domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR010703,Dedicator of cytokinesis, C-terminal;IPR035892,C2 domain superfamily;IPR021816,Dedicator of cytokinesis C/D, N-terminal;IPR027007,DHR-1 domain;IPR027357,DHR-2 domain;IPR026791,Dedicator of cytokinesis","ENOG410XNVY,-;KOG1997,PH domain-containing protein","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005622,cellular_component,intracellular","-"]
["SHQ1",1.138312629,0.168291446,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000144736","H2QMX7,SHQ1 homolog","XP_001141951.1,protein SHQ1 homolog isoform X1","PF04925,SHQ1 protein","IPR007052,CS domain;IPR008978,HSP20-like chaperone;IPR007009,SHQ1 protein","ENOG410ZIEU,-;KOG3247,Uncharacterized conserved protein","GO:2000233,biological_process,negative regulation of rRNA processing;GO:0000493,biological_process,box H/ACA snoRNP assembly;GO:0005737,cellular_component,cytoplasm;GO:0022618,biological_process,ribonucleoprotein complex assembly;GO:1904874,biological_process,positive regulation of telomerase RNA localization to Cajal body;GO:0051082,molecular_function,unfolded protein binding;GO:0005829,cellular_component,cytosol;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0005654,cellular_component,nucleoplasm","-"]
["SH3TC2",0.441874398,0.065327995,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000169247","H2QRR4,Uncharacterized protein","XP_527069.3,SH3 domain and tetratricopeptide repeat-containing protein 2 isoform X1","PF00018,SH3 domain","IPR001452,SH3 domain;IPR036028,SH3-like domain superfamily;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat","ENOG410IFSQ,-;ENOG410Y8HX,-","GO:1901184,biological_process,regulation of ERBB signaling pathway;GO:0033157,biological_process,regulation of intracellular protein transport;GO:0022011,biological_process,myelination in peripheral nervous system;GO:0005886,cellular_component,plasma membrane;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0055037,cellular_component,recycling endosome;GO:0032287,biological_process,peripheral nervous system myelin maintenance","-"]
["TBX18",0.785084906,0.116069233,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000112837","H2QTC7,Uncharacterized protein","XP_530953.2,T-box transcription factor TBX18 isoform X1","PF00907,T-box","IPR001699,Transcription factor, T-box;IPR036960,T-box superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR018186,Transcription factor, T-box, conserved site","KOG3586,TBX1 and related T-box transcription factors;ENOG410Y98J,-","GO:0072001,biological_process,renal system development;GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["ZNF783",0.988534652,0.146147835,2.715659437,2.206505149,0.000421961,0.001108673,"ENSG00000204946","G3QUC3,Zinc finger family member 783","-","PF12417,Zinc finger protein;PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR022137,Protein of unknown function DUF3669, zinc finger protein;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily;IPR001909,Krueppel-associated box","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["SKIDA1",1.311347071,0.195619967,2.713165875,2.558551017,{"v":3.36e-05,"d":"3.36E-05"},1.13158E-4,"ENSG00000180592","E9PAX1,SKI/DACH domain-containing protein 1","-","PF02437,SKI/SNO/DAC family;PF15223,omain of unknown function (DUF4584)","IPR003380,SKI/SNO/DAC domain;IPR027971,Polycomb repressive complex 2-associated factor EPOP;IPR037000,Ski-like, DNA-binding domain superfamily;IPR009061,Putative DNA-binding domain superfamily","-","-","-"]
["MUC2",0.693615329,0.103469944,2.713165875,2.558551017,{"v":3.36e-05,"d":"3.36E-05"},1.13158E-4,"ENSG00000198788","A0A0G2JR65,Mucin-2","-","PF13330,Mucin-2 protein WxxW repeating region;PF00094,von Willebrand factor type D domain;PF08742,C8 domain;PF01826,Trypsin Inhibitor like cysteine rich domain","IPR025155,WxxW domain;IPR002919,Trypsin Inhibitor-like, cysteine rich domain;IPR036084,Serine protease inhibitor-like superfamily;IPR001846,von Willebrand factor, type D domain;IPR006207,Cystine knot, C-terminal;IPR014853,Uncharacterised domain, cysteine-rich;IPR028580,Mucin-2;IPR001007,VWFC domain","-","GO:0070701,cellular_component,mucus layer;GO:0005576,cellular_component,extracellular region","-"]
["GNAZ",2.288027442,0.341316089,2.713165875,2.558551017,{"v":3.36e-05,"d":"3.36E-05"},1.13158E-4,"ENSG00000128266","F7I574,G protein subunit alpha z","XP_002743656.1,-","PF00503,-protein alpha subunit","IPR011025,G protein alpha subunit, helical insertion;IPR001408,G-protein alpha subunit, group I;IPR001019,Guanine nucleotide binding protein (G-protein), alpha subunit;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410XNVQ,-;KOG0082,G-protein alpha subunit (small G protein superfamily)","GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding;GO:0004871,molecular_function,signal transducer activity;GO:0019001,molecular_function,guanyl nucleotide binding;GO:0003924,molecular_function,GTPase activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0031683,molecular_function,G-protein beta/gamma-subunit complex binding;GO:0007188,biological_process,adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007165,biological_process,signal transduction","K04535,ko04730,Long-term depression"]
["AC055764.1",18.5751065,2.770938225,2.713165875,2.558551017,{"v":3.36e-05,"d":"3.36E-05"},1.13158E-4,"ENSG00000234136","F7H456,Leucine rich repeats and calponin homology domain containing 3","-","PF13855,Leucine rich repeat;PF00307,Calponin homology (CH) domain","IPR001611,Leucine-rich repeat;IPR001715,Calponin homology domain;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily;IPR036872,CH domain superfamily","-","-","-"]
["BEND6",1.572302322,0.234547921,2.713165875,2.558551017,{"v":3.36e-05,"d":"3.36E-05"},1.13158E-4,"ENSG00000151917","G1QRH8,BEN domain containing 6","XP_003254165.1,BEN domain-containing protein 6","PF10523,BEN domain","IPR037496,BEN domain-containing protein 6;IPR018379,BEN domain","ENOG4111841,-;ENOG410IEM7,-","GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0045746,biological_process,negative regulation of Notch signaling pathway;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:1903507,biological_process,negative regulation of nucleic acid-templated transcription;GO:0001106,molecular_function,RNA polymerase II transcription corepressor activity;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["ZNF496",5.727364628,0.871197081,2.712221062,5.163948141,{"v":9.75e-17,"d":"9.75E-17"},{"v":4.28e-15,"d":"4.28E-15"},"ENSG00000162714","A0A024R5Q5,Zinc finger protein 496, isoform CRA_b","NP_116141.1,zinc finger protein 496 isoform 1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF02023,SCAN domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR003309,SCAN domain;IPR001909,Krueppel-associated box;IPR027767,Zinc finger protein 496;IPR038269,SCAN domain superfamily;IPR036051,KRAB domain superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003677,molecular_function,DNA binding;GO:0043621,molecular_function,protein self-association;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0046872,molecular_function,metal ion binding;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus","-"]
["ZNF319",2.55572454,0.383321765,2.711647104,2.839631505,{"v":9.45e-06,"d":"9.45E-06"},{"v":3.61e-05,"d":"3.61E-05"},"ENSG00000166188","K7CWY1,Zinc finger protein 319","XP_016785425.1,-;XP_016785424.1,-;XP_016785422.1,-","PF00096,Zinc finger, C2H2 type;PF13465,Zinc-finger double domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0005634,cellular_component,nucleus","-"]
["IFT43",3.13046692,0.471232184,2.710624978,3.073729979,{"v":1.04E-6,"d":"1.04E-06"},{"v":4.89e-06,"d":"4.89E-06"},"ENSG00000119650","A0A024R6A9,HCG2028821, isoform CRA_h","NP_443105.2,intraflagellar transport protein 43 homolog isoform 1","PF15305,Intraflagellar transport protein 43","IPR029302,Intraflagellar transport protein 43","ENOG4111KGC,-;ENOG410IG89,-","GO:0015630,cellular_component,microtubule cytoskeleton;GO:0005815,cellular_component,microtubule organizing center;GO:0030991,cellular_component,intraciliary transport particle A;GO:0005929,cellular_component,cilium","-"]
["ZNF204P",5.448605753,0.820183843,2.710624978,3.073729979,{"v":1.04E-6,"d":"1.04E-06"},{"v":4.89e-06,"d":"4.89E-06"},"-","-","-","-","-","-","-","-"]
["ZNF680",2.720631811,0.410605821,2.709890124,3.27440589,{"v":1.3E-7,"d":"1.30E-07"},{"v":7.4e-07,"d":"7.40E-07"},"ENSG00000173041","G1R806,Zinc finger protein 680","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","-","-","-","-"]
["OSBPL5",2.6080541,0.394986741,2.708904078,3.60632461,{"v":1.13E-8,"d":"1.13E-08"},{"v":8.22e-08,"d":"8.22E-08"},"ENSG00000021762","K7CL39,Oxysterol-binding protein","-","PF01237,Oxysterol-binding protein;PF00169,PH domain","IPR000648,Oxysterol-binding protein;IPR037239,Oxysterol-binding protein superfamily;IPR001849,Pleckstrin homology domain;IPR018494,Oxysterol-binding protein, conserved site;IPR011993,PH-like domain superfamily","-","GO:0006869,biological_process,lipid transport","-"]
["LINC00470",4.792451861,0.725811225,2.708904078,3.60632461,{"v":1.13E-8,"d":"1.13E-08"},{"v":8.22e-08,"d":"8.22E-08"},"ENSG00000132204","H2RH36,Uncharacterized protein","-","-","-","-","-","-"]
["KLF12",2.565256536,0.389968396,2.707834124,4.10101519,{"v":5.33e-11,"d":"5.33E-11"},{"v":6.47e-10,"d":"6.47E-10"},"ENSG00000118922","G3QNE9,Kruppel like factor 12","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm","-"]
["TSHZ1",4.415995939,0.672657718,2.707264262,4.467516564,6.64E-13,1.26E-11,"ENSG00000179981","H2NWL5,Teashirt zinc finger homeobox 1","XP_009250755.1,teashirt homolog 1 isoform X1","-","IPR013087,Zinc finger C2H2-type;IPR027008,Teashirt family;IPR001356,Homeobox domain;IPR026808,Teashirt  homologue 1","ENOG410XQQR,-;ENOG410IJEQ,-","GO:0042474,biological_process,middle ear morphogenesis;GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0060023,biological_process,soft palate development;GO:0010468,biological_process,regulation of gene expression;GO:0009952,biological_process,anterior/posterior pattern specification","-"]
["GORASP2",29.61581587,4.540654482,2.703663079,6.529267213,{"v":2.37e-24,"d":"2.37E-24"},{"v":3.89e-22,"d":"3.89E-22"},"ENSG00000115806","G3S170,Golgi reassembly stacking protein 2","-","PF04495,RASP55/65 PDZ-like domain","-","-","-","-"]
["EML1",4.56294919,0.699584836,2.698663627,4.613587176,{"v":1.7e-13,"d":"1.70E-13"},{"v":3.69e-12,"d":"3.69E-12"},"ENSG00000066629","H2R968,Uncharacterized protein","XP_001157076.2,echinoderm microtubule-associated protein-like 1 isoform X3","PF03451,HELP motif;PF00400,WD domain, G-beta repeat","IPR005108,HELP;IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","ENOG410XNTQ,-;KOG2106,Uncharacterized conserved protein, contains HELP and WD40 domains","GO:1990023,cellular_component,mitotic spindle midzone;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0007405,biological_process,neuroblast proliferation;GO:0097431,cellular_component,mitotic spindle pole;GO:0007420,biological_process,brain development;GO:0007052,biological_process,mitotic spindle organization;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0005829,cellular_component,cytosol;GO:0015631,molecular_function,tubulin binding;GO:0008017,molecular_function,microtubule binding;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["KCNH7",14.56078494,2.239758169,2.696908196,5.423003241,{"v":3.16e-18,"d":"3.16E-18"},{"v":1.89e-16,"d":"1.89E-16"},"ENSG00000184611","H2QIW5,Uncharacterized protein","XP_525954.2,potassium voltage-gated channel subfamily H member 7 isoform X3","PF13426,PAS domain;PF00027,Cyclic nucleotide-binding domain;PF00520,Ion transport protein","IPR000014,PAS domain;IPR014710,RmlC-like jelly roll fold;IPR003967,Potassium channel, voltage-dependent, ERG;IPR000595,Cyclic nucleotide-binding domain;IPR035965,PAS domain superfamily;IPR018490,Cyclic nucleotide-binding-like;IPR027359,Voltage-dependent channel domain superfamily;IPR005821,Ion transport domain;IPR003938,Potassium channel, voltage-dependent, EAG/ELK/ERG","ENOG410XPSE,-;KOG0498,K+-channel ERG and related proteins, contain PAS/PAC sensor domain","GO:0005216,molecular_function,ion channel activity;GO:0005267,molecular_function,potassium channel activity;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0055085,biological_process,transmembrane transport;GO:0005249,molecular_function,voltage-gated potassium channel activity;GO:0006811,biological_process,ion transport;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0016020,cellular_component,membrane;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0006813,biological_process,potassium ion transport;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0042391,biological_process,regulation of membrane potential","-"]
["LAMP3",8.400712687,1.28798524,2.696875628,4.287103792,{"v":9.7e-12,"d":"9.70E-12"},{"v":1.4e-10,"d":"1.40E-10"},"ENSG00000078081","B2R7Z2,cDNA, FLJ93669, highly similar to Homo sapiens lysosomal-associated membrane protein 3","-","PF01299,Lysosome-associated membrane glycoprotein (Lamp)","IPR002000,Lysosome-associated membrane glycoprotein","KOG4818,Lysosomal-associated membrane protein;ENOG410XQ96,-","GO:0005764,cellular_component,lysosome;GO:0016021,cellular_component,integral component of membrane;GO:0005765,cellular_component,lysosomal membrane;GO:0016020,cellular_component,membrane","-"]
["PPARA",2.263407089,0.347022334,2.696269671,4.192330898,{"v":1.63e-11,"d":"1.63E-11"},2.25E-10,"ENSG00000186951","G3R7V1,Peroxisome proliferator activated receptor alpha","-","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","-","-","-","-"]
["ACADSB",4.100031285,0.628610926,2.694756299,3.981501416,{"v":2.51e-10,"d":"2.51E-10"},{"v":2.63e-09,"d":"2.63E-09"},"ENSG00000196177","A0A0S2Z3P9,Acyl-CoA dehydrogenase short/branched chain isoform 1","NP_001600.1,short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1 precursor","PF00441,Acyl-CoA dehydrogenase, C-terminal domain;PF02771,Acyl-CoA dehydrogenase, N-terminal domain;PF02770,Acyl-CoA dehydrogenase, middle domain","IPR036250,Acyl-CoA dehydrogenase-like, C-terminal;IPR013786,Acyl-CoA dehydrogenase/oxidase, N-terminal;IPR009100,Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily;IPR037069,Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily;IPR009075,Acyl-CoA dehydrogenase/oxidase C-terminal;IPR006091,Acyl-CoA oxidase/dehydrogenase, central domain;IPR006089,Acyl-CoA dehydrogenase, conserved site","-","GO:0016627,molecular_function,oxidoreductase activity, acting on the CH-CH group of donors;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0016491,molecular_function,oxidoreductase activity;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0003995,molecular_function,acyl-CoA dehydrogenase activity","K09478,ko01212,Fatty acid metabolism;K09478,ko00280,Valine, leucine and isoleucine degradation;K09478,ko00071,Fatty acid degradation"]
["PGM3",3.496345697,0.536054716,2.694756299,3.981501416,{"v":2.51e-10,"d":"2.51E-10"},{"v":2.63e-09,"d":"2.63E-09"},"ENSG00000013375","G3S9W3,Phosphoacetylglucosamine mutase","-","PF00408,Phosphoglucomutase/phosphomannomutase, C-terminal domain;PF02878,Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I","IPR016657,Phosphoacetylglucosamine mutase;IPR005843,Alpha-D-phosphohexomutase, C-terminal;IPR005844,Alpha-D-phosphohexomutase, alpha/beta/alpha domain I;IPR016066,Alpha-D-phosphohexomutase, conserved site;IPR016055,Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III;IPR036900,Alpha-D-phosphohexomutase, C-terminal domain superfamily","-","GO:0007283,biological_process,spermatogenesis;GO:0005975,biological_process,carbohydrate metabolic process;GO:0030097,biological_process,hemopoiesis;GO:0004610,molecular_function,phosphoacetylglucosamine mutase activity;GO:0016868,molecular_function,intramolecular transferase activity, phosphotransferases;GO:0006487,biological_process,protein N-linked glycosylation;GO:0046872,molecular_function,metal ion binding;GO:0004614,molecular_function,phosphoglucomutase activity;GO:0000287,molecular_function,magnesium ion binding;GO:0006048,biological_process,UDP-N-acetylglucosamine biosynthetic process;GO:0006493,biological_process,protein O-linked glycosylation;GO:0016853,molecular_function,isomerase activity;GO:0019255,biological_process,glucose 1-phosphate metabolic process;GO:0071704,biological_process,organic substance metabolic process","-"]
["RPTOR",5.892876116,0.907364956,2.694297148,5.045283121,{"v":4.36e-16,"d":"4.36E-16"},{"v":1.7E-14,"d":"1.70E-14"},"ENSG00000141564","K7CSM3,Regulatory associated protein of MTOR, complex 1","XP_016788587.1,-","PF00400,WD domain, G-beta repeat;PF02985,HEAT repeat;PF14538,Raptor N-terminal CASPase like domain","IPR029347,Raptor, N-terminal CASPase-like domain;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR004083,Regulatory associated protein of TOR;IPR011989,Armadillo-like helical;IPR000357,HEAT repeat;IPR016024,Armadillo-type fold;IPR001680,WD40 repeat","ENOG410XQKJ,-;KOG1517,Guanine nucleotide binding protein MIP1","GO:0031931,cellular_component,TORC1 complex;GO:0031929,biological_process,TOR signaling","K07204,ko04150,mTOR signaling pathway;K07204,ko04910,Insulin signaling pathway;K07204,ko04152,AMPK signaling pathway;K07204,ko04151,PI3K-Akt signaling pathway;K07204,ko04211,Longevity regulating pathway;K07204,ko05206,MicroRNAs in cancer;K07204,ko04213,Longevity regulating pathway - multiple species"]
["SMAD1",3.880580123,0.594964988,2.693794371,3.863094853,{"v":1.27E-9,"d":"1.27E-09"},{"v":1.14E-8,"d":"1.14E-08"},"ENSG00000170365","A0A1D5Q7V1,Mothers against decapentaplegic homolog","XP_014994751.1,-;XP_014994750.1,-;NP_001248296.1,-;XP_014994753.1,-;XP_014994752.1,-","-","IPR003619,MAD homology 1, Dwarfin-type;IPR001132,SMAD domain, Dwarfin-type;IPR013790,Dwarfin;IPR017855,SMAD-like domain superfamily;IPR008984,SMAD/FHA domain superfamily;IPR036578,SMAD MH1 domain superfamily;IPR013019,MAD homology, MH1","ENOG410XQKU,-;KOG3701,TGFbeta receptor signaling protein SMAD and related proteins","GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0005737,cellular_component,cytoplasm;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","K04676,ko04550,Signaling pathways regulating pluripotency of stem cells;K04676,ko04350,TGF-beta signaling pathway;K04676,ko04390,Hippo signaling pathway;K04676,ko04391,Hippo signaling pathway - fly;K04676,ko05202,Transcriptional misregulation in cancer"]
["MUC15",4.457684491,0.683445803,2.687221795,3.255992816,{"v":1.91E-7,"d":"1.91E-07"},{"v":1.05e-06,"d":"1.05E-06"},"ENSG00000169550","A0A0A0MT67,Mucin-15","NP_001128563.1,mucin-15 isoform a","PF15672,Cell-membrane associated Mucin15","IPR031371,Cell-membrane associated Mucin-15","ENOG41113G6,-;ENOG410IM00,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["LRRC37A4P",2.160599242,0.331259982,2.687221795,3.255992816,{"v":1.91E-7,"d":"1.91E-07"},{"v":1.05e-06,"d":"1.05E-06"},"ENSG00000214425","A8MUI5,Leucine-rich repeat-containing protein 37A","-","PF14914,LRRC37A/B like protein 1 C-terminal domain;PF13855,Leucine rich repeat;PF15779,Leucine-rich repeat-containing protein 37 family","IPR001611,Leucine-rich repeat;IPR032754,Leucine-rich repeat-containing protein 37, N-terminal;IPR032675,Leucine-rich repeat domain superfamily;IPR029423,LRRC37A/B like protein 1, C-terminal;IPR003591,Leucine-rich repeat, typical subtype;IPR015753,Leucine-rich repeat-containing protein 37","ENOG410YV94,-;ENOG410IJNR,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TMEM217",5.465834546,0.838013926,2.687221795,3.255992816,{"v":1.91E-7,"d":"1.91E-07"},{"v":1.05e-06,"d":"1.05E-06"},"ENSG00000172738","H2QSX6,Transmembrane protein 217","XP_009449446.1,-","PF15049,Protein of unknown function (DUF4534)","IPR027862,Protein of unknown function DUF4534","ENOG410YZ2V,-;ENOG410IX9G,-","GO:0016020,cellular_component,membrane;GO:0005730,cellular_component,nucleolus;GO:0016021,cellular_component,integral component of membrane;GO:0001650,cellular_component,fibrillar center","-"]
["CTD-2031P19.5",16.08889316,2.466726061,2.684222992,3.052451975,{"v":1.55E-6,"d":"1.55E-06"},{"v":7.07e-06,"d":"7.07E-06"},"ENSG00000262211","H2R0A7,Interleukin 6 signal transducer","-","PF00041,ibronectin type III domain;PF09240,Interleukin-6 receptor alpha chain, binding;PF06328,Ig-like C2-type domain","IPR003529,Long hematopoietin receptor, Gp130 family 2, conserved site;IPR010457,Immunoglobulin C2-set-like, ligand-binding;IPR036116,Fibronectin type III superfamily;IPR003961,Fibronectin type III;IPR013783,Immunoglobulin-like fold;IPR015321,Type I cytokine receptor, cytokine-binding domain","ENOG410YNQ4,-;ENOG410IF1N,-","GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0004896,molecular_function,cytokine receptor activity;GO:0016020,cellular_component,membrane","K05060,ko04630,Jak-STAT signaling pathway;K05060,ko04060,Cytokine-cytokine receptor interaction;K05060,ko04550,Signaling pathways regulating pluripotency of stem cells;K05060,ko05203,Viral carcinogenesis"]
["PLEKHB1",2.166167958,0.33211377,2.680038948,2.814426233,{"v":1.43E-5,"d":"1.43E-05"},{"v":5.26e-05,"d":"5.26E-05"},"ENSG00000021300","A0A024R5H9,Pleckstrin homology domain containing, family B","NP_067023.1,pleckstrin homology domain-containing family B member 1 isoform a","PF00169,PH domain","IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","ENOG410IXBE,-;ENOG410Y287,-","GO:0045595,biological_process,regulation of cell differentiation","-"]
["CNOT6LP1",7.3089648,1.120600017,2.680038948,2.814426233,{"v":1.43E-5,"d":"1.43E-05"},{"v":5.26e-05,"d":"5.26E-05"},"ENSG00000230183","A0A1S3FG18,CCR4-NOT transcription complex subunit 6-like","XP_012875553.1,CCR4-NOT transcription complex subunit 6-like","-","IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR005135,Endonuclease/exonuclease/phosphatase;IPR032675,Leucine-rich repeat domain superfamily;IPR034967,CCR4-NOT transcription complex subunit 6-like","-","GO:0004535,molecular_function,poly(A)-specific ribonuclease activity;GO:0090503,biological_process,RNA phosphodiester bond hydrolysis, exonucleolytic","-"]
["ZNF616",4.320988127,0.669931395,2.676547613,3.72067391,{"v":3.76e-09,"d":"3.76E-09"},{"v":3.04e-08,"d":"3.04E-08"},"ENSG00000204611","H2QFX3,Uncharacterized protein","XP_512866.2,zinc finger protein 616 isoform X2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["LRP12",2.16159895,0.335137,2.676547613,3.72067391,{"v":3.76e-09,"d":"3.76E-09"},{"v":3.04e-08,"d":"3.04E-08"},"ENSG00000147650","K7BJL2,Low density lipoprotein receptor-related protein 12","XP_009454055.1,low-density lipoprotein receptor-related protein 12 isoform X1","PF00431,CUB domain;PF00057,Low-density lipoprotein receptor domain class A","IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR000859,CUB domain;IPR035914,Spermadhesin, CUB domain superfamily;IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR036055,LDL receptor-like superfamily","ENOG410YUIT,-;ENOG410IPT2,-","GO:0031175,biological_process,neuron projection development;GO:0005887,cellular_component,integral component of plasma membrane;GO:0001764,biological_process,neuron migration","-"]
["OLMALINC",3.351064379,0.513780392,2.673793888,2.52763155,{"v":5.25e-05,"d":"5.25E-05"},1.69653E-4,"ENSG00000235823","A0A0A0WBS4,Embryonic stem cell related protein","-","-","-","-","-","-"]
["INPP5E",1.317190328,0.201949735,2.673793888,2.52763155,{"v":5.25e-05,"d":"5.25E-05"},1.69653E-4,"ENSG00000148384","K7B557,Inositol polyphosphate-5-phosphatase, 72 kDa","NP_001070981.1,72 kDa inositol polyphosphate 5-phosphatase","PF03372,ndonuclease/Exonuclease/phosphatase family","IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR000300,Inositol polyphosphate-related phosphatase;IPR005135,Endonuclease/exonuclease/phosphatase","-","GO:0046856,biological_process,phosphatidylinositol dephosphorylation;GO:0016787,molecular_function,hydrolase activity","K20278,ko04070,Phosphatidylinositol signaling system;K20278,ko00562,Inositol phosphate metabolism"]
["TNFSF15",2.408012628,0.373807961,2.673343811,3.577146304,{"v":1.6e-08,"d":"1.60E-08"},{"v":1.13e-07,"d":"1.13E-07"},"ENSG00000181634","A0A0U5JA19,Tumor necrosis factor ligand 1B","NP_005109.2,tumor necrosis factor ligand superfamily member 15 isoform VEGI-251 precursor","PF00229,TNF(Tumour Necrosis Factor) family","IPR006053,Tumour necrosis factor;IPR008064,Tumor necrosis factor ligand superfamily member 15;IPR008983,Tumour necrosis factor-like domain superfamily;IPR006052,Tumour necrosis factor domain","-","GO:0006915,biological_process,apoptotic process;GO:0005164,molecular_function,tumor necrosis factor receptor binding;GO:0005125,molecular_function,cytokine activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0006955,biological_process,immune response;GO:0016021,cellular_component,integral component of membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space","K05478,ko04060,Cytokine-cytokine receptor interaction"]
["BCL6",10.91724817,1.710604041,2.669916793,5.270527929,{"v":2.98e-17,"d":"2.98E-17"},{"v":1.45e-15,"d":"1.45E-15"},"ENSG00000113916","G3SJM6,B-cell CLL/lymphoma 6","XP_004038239.1,B-cell lymphoma 6 protein isoform X2","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["ZNF697",3.344509088,0.519997532,2.669339448,3.417422731,{"v":1.05E-7,"d":"1.05E-07"},{"v":6.15e-07,"d":"6.15E-07"},"ENSG00000143067","H2PZS9,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["SEC23IP",6.368894198,0.999608832,2.66629722,4.910159514,{"v":6.15e-15,"d":"6.15E-15"},{"v":1.86e-13,"d":"1.86E-13"},"ENSG00000107651","B3KM47,cDNA FLJ10273 fis, clone HEMBB1001137, highly similar to SEC23-interacting protein","-","PF02862,HD domain;PF00536,SAM domain (Sterile alpha motif)","IPR037603,SEC23-interacting protein, SAM domain;IPR004177,DDHD domain;IPR001660,Sterile alpha motif domain;IPR013761,Sterile alpha motif/pointed domain superfamily","KOG2308,Phosphatidic acid-preferring phospholipase A1, contains DDHD domain;ENOG410YDSX,-","GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0005737,cellular_component,cytoplasm;GO:0046872,molecular_function,metal ion binding","-"]
["SPATA7",0.93297787,0.143042831,2.663467182,2.166511199,0.000421961,0.001108673,"ENSG00000042317","V9HVY9,Epididymis secretory protein Li 296","NP_060888.2,spermatogenesis-associated protein 7 isoform 1","PF15244,Spermatogenesis-associated protein 7, or HSD3","IPR029357,Spermatogenesis-associated protein 7","ENOG410IKU4,-;ENOG4111WP7,-","GO:1903546,biological_process,protein localization to photoreceptor outer segment;GO:0045494,biological_process,photoreceptor cell maintenance;GO:0032391,cellular_component,photoreceptor connecting cilium;GO:0005739,cellular_component,mitochondrion;GO:0005829,cellular_component,cytosol;GO:1903621,biological_process,protein localization to photoreceptor connecting cilium;GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-72I8.1",2.467830609,0.378364255,2.663467182,2.166511199,0.000421961,0.001108673,"ENSG00000260735","A0A1A9AQR1,Uncharacterized protein","-","-","-","-","-","-"]
["RNFT1",1.886267703,0.289199863,2.663467182,2.166511199,0.000421961,0.001108673,"ENSG00000189050","K7CZJ6,Ring finger protein, transmembrane 1","-","PF13920,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG0802,E3 ubiquitin ligase;ENOG410XTGA,-;KOG4638,Uncharacterized conserved protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MPV17L2",3.003008863,0.460417019,2.663467182,2.166511199,0.000421961,0.001108673,"ENSG00000254858","H2QFS8,MPV17 mitochondrial membrane protein-like 2","XP_001173861.1,-","PF04117,Mpv17 / PMP22 family","IPR007248,Mpv17/PMP22","KOG1944,Peroxisomal membrane protein MPV17 and related proteins;ENOG4111SYH,-","GO:0061668,biological_process,mitochondrial ribosome assembly;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0070131,biological_process,positive regulation of mitochondrial translation;GO:0005762,cellular_component,mitochondrial large ribosomal subunit;GO:0016021,cellular_component,integral component of membrane;GO:0005739,cellular_component,mitochondrion","K13348,ko04146,Peroxisome"]
["FOXA2",2.463090251,0.37763747,2.663467182,2.166511199,0.000421961,0.001108673,"ENSG00000125798","B0ZTD4,Forkhead box A2","NP_068556.2,hepatocyte nuclear factor 3-beta isoform 1","PF00250,orkhead domain;PF08430,orkhead N-terminal region;PF09354,HNF3 C-terminal domain","IPR018533,Forkhead box protein, C-terminal;IPR013638,Fork-head N-terminal;IPR018122,Fork head domain conserved site1;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR001766,Fork head domain;IPR030456,Fork head domain conserved site 2;IPR036390,Winged helix DNA-binding domain superfamily","COG5025,Transcription factor of the Forkhead/HNF3 family;KOG3563,Forkhead/HNF-3-related transcription factor","GO:0019904,molecular_function,protein domain specific binding;GO:0030054,cellular_component,cell junction;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["USP54",7.225308695,1.138439007,2.662140458,5.351595703,2.08E-17,{"v":1.04e-15,"d":"1.04E-15"},"ENSG00000166348","G3R6Y1,Ubiquitin specific peptidase 54","XP_004049637.1,inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1;XP_018890517.1,-","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","-","GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016579,biological_process,protein deubiquitination","-"]
["NFE2L2",47.18224663,7.453124023,2.661389038,7.362054111,{"v":1.82e-27,"d":"1.82E-27"},4.23E-25,"ENSG00000116044","E2I973,Nuclear factor erythroid-derived 2-like 2 transcript variant 1","-","PF03131,bZIP Maf transcription factor","IPR004826,Basic leucine zipper domain, Maf-type;IPR008917,Transcription factor, Skn-1-like, DNA-binding domain superfamily;IPR029845,Nuclear factor erythroid 2-related factor 2;IPR004827,Basic-leucine zipper domain","ENOG410ISV3,-;ENOG41100FB,-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0034599,biological_process,cellular response to oxidative stress","-"]
["FAM86C2P",6.142414105,0.963149456,2.660272458,3.707297322,{"v":3.76e-09,"d":"3.76E-09"},{"v":3.04e-08,"d":"3.04E-08"},"ENSG00000160172","K7CAR1,Family with sequence similarity 86, member A","XP_016784858.1,protein-lysine N-methyltransferase EEF2KMT isoform X1","PF10294,Lysine methyltransferase;PF14904,amily of unknown function","IPR029426,FAM86;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR019410,Lysine methyltransferase","-","GO:0005737,cellular_component,cytoplasm;GO:0016279,molecular_function,protein-lysine N-methyltransferase activity;GO:0018023,biological_process,peptidyl-lysine trimethylation;GO:0032991,cellular_component,protein-containing complex","-"]
["GLTSCR1",2.78360101,0.436477215,2.660272458,3.707297322,{"v":3.76e-09,"d":"3.76E-09"},{"v":3.04e-08,"d":"3.04E-08"},"ENSG00000063169","H2QGP8,BRD4 interacting chromatin remodeling complex associated protein","XP_003316527.1,glioma tumor suppressor candidate region gene 1 protein isoform X1;XP_009434213.1,-","PF15249,Conserved region of unknown function on GLTSCR protein","IPR015671,GLTSCR protein, conserved region","ENOG41126SK,-;ENOG410IIYC,-","-","-"]
["RP11-47I22.4",21.33788212,3.364964776,2.648917336,3.400804049,{"v":1.52e-07,"d":"1.52E-07"},{"v":8.55e-07,"d":"8.55E-07"},"ENSG00000258989","H0YJX3,Uncharacterized protein","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR000719,Protein kinase domain","KOG0694,Serine/threonine protein kinase;ENOG410XNPH,-","GO:0016301,molecular_function,kinase activity;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["CCDC92",16.25806419,2.590067364,2.648135669,6.297302636,1.62E-22,2.03E-20,"ENSG00000119242","K7CM86,Coiled-coil domain containing 92","XP_016778152.1,-;XP_016778153.1,-;XP_016778149.1,-;XP_016778151.1,-;XP_016778150.1,-","PF14916,Coiled-coil domain of unknown function","IPR033224,Coiled-coil domain-containing protein 92","ENOG410ZQ07,-;ENOG410IIA1,-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005813,cellular_component,centrosome;GO:0005814,cellular_component,centriole;GO:0005654,cellular_component,nucleoplasm","-"]
["GPN2",2.098462822,0.329045436,2.647722744,2.788751665,{"v":2.16E-5,"d":"2.16E-05"},{"v":7.65e-05,"d":"7.65E-05"},"ENSG00000142751","G1RDX4,GPN-loop GTPase 2","XP_003271714.1,-","PF03029,Conserved hypothetical ATP binding protein","IPR004130,GPN-loop GTPase;IPR030231,GPN-loop GTPase 2;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410YRVC,-;KOG1533,Predicted GTPase","-","-"]
["TUBGCP5",1.612881505,0.252904789,2.647722744,2.788751665,{"v":2.16E-5,"d":"2.16E-05"},{"v":7.65e-05,"d":"7.65E-05"},"ENSG00000275835","A0A087X1Z1,Gamma-tubulin complex component","-","PF04130,Spc97 / Spc98 family","IPR007259,Gamma-tubulin complex component protein","ENOG410ZYW9,-;KOG4344,Uncharacterized conserved protein","GO:0005874,cellular_component,microtubule;GO:0007020,biological_process,microtubule nucleation;GO:0005737,cellular_component,cytoplasm;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0043015,molecular_function,gamma-tubulin binding;GO:0005856,cellular_component,cytoskeleton;GO:0005815,cellular_component,microtubule organizing center;GO:0000922,cellular_component,spindle pole","-"]
["AMER1",1.237504014,0.194044442,2.647722744,2.788751665,{"v":2.16E-5,"d":"2.16E-05"},{"v":7.65e-05,"d":"7.65E-05"},"ENSG00000184675","G3RNF3,APC membrane recruitment protein 1","-","PF09422,WTX protein","-","-","-","-"]
["ZNF827",3.181903998,0.505113813,2.645448355,4.049237008,{"v":1.82e-10,"d":"1.82E-10"},{"v":1.97E-9,"d":"1.97E-09"},"ENSG00000151612","G3SHH4,Zinc finger protein 827","XP_018881127.1,zinc finger protein 827 isoform X3","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["ZNF362",88.04061226,14.06660842,2.645004558,7.419862272,{"v":1.89e-27,"d":"1.89E-27"},{"v":4.34e-25,"d":"4.34E-25"},"ENSG00000160094","A0A287D732,Zinc finger protein 362","XP_005317835.1,zinc finger protein 362","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["PLEKHG2",4.697581135,0.747927429,2.64489767,4.706858184,{"v":7.28e-14,"d":"7.28E-14"},1.71E-12,"ENSG00000090924","G3REQ9,Pleckstrin homology and RhoGEF domain containing G2","-","PF00621,RhoGEF domain;PF00169,PH domain","IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR001849,Pleckstrin homology domain;IPR035899,Dbl homology (DH) domain superfamily","-","GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0030833,biological_process,regulation of actin filament polymerization;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0065009,biological_process,regulation of molecular function","-"]
["TTLL4",4.820271004,0.76746155,2.643892697,4.493147644,{"v":9.23e-13,"d":"9.23E-13"},{"v":1.69e-11,"d":"1.69E-11"},"ENSG00000135912","A0A024R424,Tubulin tyrosine ligase-like family, member 4, isoform CRA_a","NP_055455.3,tubulin polyglutamylase TTLL4","PF03133,Tubulin-tyrosine ligase family","IPR013815,ATP-grasp fold, subdomain 1;IPR027748,Tubulin polyglutamylase TTLL-4;IPR004344,Tubulin-tyrosine ligase/Tubulin polyglutamylase","ENOG410XTI2,-;KOG2156,Tubulin-tyrosine ligase-related protein","GO:0070739,molecular_function,protein-glutamic acid ligase activity;GO:0018095,biological_process,protein polyglutamylation;GO:0018200,biological_process,peptidyl-glutamic acid modification;GO:0016874,molecular_function,ligase activity;GO:0015631,molecular_function,tubulin binding;GO:0005524,molecular_function,ATP binding;GO:0006464,biological_process,cellular protein modification process","-"]
["PRG4",0.847399408,0.129922064,2.643113959,1.678041601,0.006393092,0.01278539,"ENSG00000116690","A0A024R930,Proteoglycan 4, isoform CRA_a","-","PF01033,Somatomedin B domain;PF00045,Hemopexin","IPR000585,Hemopexin-like domain;IPR018486,Hemopexin, conserved site;IPR020436,Somatomedin B, chordata;IPR036375,Hemopexin-like domain superfamily;IPR001212,Somatomedin B domain;IPR036024,Somatomedin B-like domain superfamily;IPR018487,Hemopexin-like repeats","KOG1565,Gelatinase A and related matrix metalloproteases;ENOG410XQ5D,-","GO:0006955,biological_process,immune response;GO:0006898,biological_process,receptor-mediated endocytosis;GO:0005044,molecular_function,scavenger receptor activity;GO:0030247,molecular_function,polysaccharide binding","-"]
["ADCK1",0.803889903,0.123251249,2.643113959,1.678041601,0.006393092,0.01278539,"ENSG00000063761","H2Q8Q2,AarF domain containing kinase 1","XP_510098.3,uncharacterized aarF domain-containing protein kinase 1 isoform X1","PF03109,ABC1 family","IPR004147,UbiB domain;IPR011009,Protein kinase-like domain superfamily","KOG1235,Predicted unusual protein kinase;COG0661,Predicted unusual protein kinase","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation","-"]
["TBC1D3L",1.90137127,0.291515521,2.643113959,1.678041601,0.006393092,0.01278539,"ENSG00000274512","A0A0G2JPY0,TBC1 domain family member 3K","-","PF00566,Rab-GTPase-TBC domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain","-","GO:0012505,cellular_component,endomembrane system;GO:0090630,biological_process,activation of GTPase activity;GO:0005622,cellular_component,intracellular;GO:0031338,biological_process,regulation of vesicle fusion;GO:0005096,molecular_function,GTPase activator activity;GO:0017137,molecular_function,Rab GTPase binding;GO:0006886,biological_process,intracellular protein transport","-"]
["CTD-2047H16.4",1.073131462,0.164530979,2.643113959,1.678041601,0.006393092,0.01278539,"ENSG00000263069","Q6ZUT0,HCG2045502","-","-","-","-","-","-"]
["TTC30A",0.715361107,0.109678141,2.643113959,1.678041601,0.006393092,0.01278539,"ENSG00000197557","A0A0D9SBD8,Tetratricopeptide repeat domain 30A","XP_007963643.1,tetratricopeptide repeat protein 30A","PF14559,Tetratricopeptide repeat","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","-","-","-"]
["WDR5B",1.149000703,0.176163143,2.643113959,1.678041601,0.006393092,0.01278539,"ENSG00000196981","H2R2L6,WD repeat domain 5B","XP_516691.2,WD repeat-containing protein 5B","PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat","ENOG410XP3K,-;KOG0266,WD40 repeat-containing protein","GO:0060271,biological_process,cilium assembly;GO:0036064,cellular_component,ciliary basal body","-"]
["HOXA6",3.326289973,0.509982016,2.643113959,1.678041601,0.006393092,0.01278539,"ENSG00000106006","A0A0D9RP79,Homeobox A6","XP_007980006.1,-","PF00046,Homeobox domain","IPR009057,Homeobox-like domain superfamily;IPR017995,Homeobox protein, antennapedia type;IPR017970,Homeobox, conserved site;IPR020479,Homeobox domain, metazoa;IPR001827,Homeobox protein, antennapedia type, conserved site;IPR001356,Homeobox domain","-","GO:0048706,biological_process,embryonic skeletal system development;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0048704,biological_process,embryonic skeletal system morphogenesis;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0007275,biological_process,multicellular organism development","-"]
["QSER1",20.39493513,3.265128759,2.641787552,6.975249791,{"v":1.09e-25,"d":"1.09E-25"},{"v":2.11e-23,"d":"2.11E-23"},"ENSG00000060749","G3R0G8,Glutamine and serine rich 1","XP_018892977.1,glutamine and serine-rich protein 1 isoform X3","PF13926,omain of unknown function (DUF4211)","IPR025451,Domain of unknown function DUF4211","-","-","-"]
["RP11-29H23.5",5.78246262,0.915626393,2.640787787,3.218416662,{"v":4.14e-07,"d":"4.14E-07"},{"v":2.11e-06,"d":"2.11E-06"},"ENSG00000246203","G3RVP1,Uncharacterized protein","-","-","IPR033277,GON-4-like protein","-","GO:0030183,biological_process,B cell differentiation;GO:0003714,molecular_function,transcription corepressor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["KRT8P46",10.1578323,1.608446084,2.640787787,3.218416662,{"v":4.14e-07,"d":"4.14E-07"},{"v":2.11e-06,"d":"2.11E-06"},"ENSG00000248971","H2Q999,Tau tubulin kinase 2","-","PF00038,Intermediate filament protein;PF00069,Protein kinase domain;PF16208,Keratin type II head","IPR032444,Keratin type II head;IPR018039,Intermediate filament protein, conserved site;IPR011009,Protein kinase-like domain superfamily;IPR003054,Keratin, type II;IPR001664,Intermediate filament protein;IPR000719,Protein kinase domain","KOG1164,Casein kinase (serine/threonine/tyrosine protein kinase);ENOG410XPGP,-","GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0006468,biological_process,protein phosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0005634,cellular_component,nucleus;GO:0045095,cellular_component,keratin filament;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005198,molecular_function,structural molecule activity;GO:0008360,biological_process,regulation of cell shape;GO:0005882,cellular_component,intermediate filament;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["CACHD1",5.501440718,0.877900483,2.640214667,4.411456659,{"v":3.39e-12,"d":"3.39E-12"},{"v":5.41e-11,"d":"5.41E-11"},"ENSG00000158966","A0A0A0MQY7,VWFA and cache domain-containing protein 1","NP_065976.2,VWFA and cache domain-containing protein 1 isoform 1","PF00092,von Willebrand factor type A domain;PF08399,VWA N-terminal","IPR002035,von Willebrand factor, type A;IPR036465,von Willebrand factor A-like domain superfamily;IPR013608,VWA N-terminal;IPR029151,Periplasmic sensor-like domain superfamily","ENOG410XPDX,-;KOG2353,L-type voltage-dependent Ca2+ channel, alpha2/delta subunit","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SEC24D",3.518814653,0.561520017,2.640214667,4.411456659,{"v":3.39e-12,"d":"3.39E-12"},{"v":5.41e-11,"d":"5.41E-11"},"ENSG00000150961","A8K6V0,cDNA FLJ78676, highly similar to Homo sapiens SEC24 related gene family, member D","NP_055637.2,protein transport protein Sec24D isoform 1","PF04815,Sec23/Sec24 helical domain;PF04811,Sec23/Sec24 trunk domain;PF08033,Sec23/Sec24 beta-sandwich domain;PF00626,elsolin repeat;PF04810,Sec23/Sec24 zinc finger","IPR007123,Gelsolin-like domain;IPR036180,Gelsolin-like domain superfamily;IPR036465,von Willebrand factor A-like domain superfamily;IPR006900,Sec23/Sec24, helical domain;IPR029006,ADF-H/Gelsolin-like domain superfamily;IPR006895,Zinc finger, Sec23/Sec24-type;IPR036175,Sec23/Sec24 helical domain superfamily;IPR006896,Sec23/Sec24, trunk domain;IPR012990,Sec23/Sec24 beta-sandwich","COG5028,Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3;KOG1985,Vesicle coat complex COPII, subunit SEC24/subunit SFB2","GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0015031,biological_process,protein transport;GO:0030127,cellular_component,COPII vesicle coat;GO:0008270,molecular_function,zinc ion binding;GO:0006886,biological_process,intracellular protein transport","K14007,ko04141,Protein processing in endoplasmic reticulum"]
["MBNL1",35.34920773,5.674819902,2.638296237,7.687035656,{"v":3.49e-28,"d":"3.49E-28"},8.51E-26,"ENSG00000152601","A0A0A0MQX8,Muscleblind-like protein 1","XP_005247521.1,muscleblind-like protein 1 isoform X5;XP_016861912.1,-;XP_016861913.1,-","PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR000571,Zinc finger, CCCH-type","ENOG410ZNRC,-;KOG2494,C3H1-type Zn-finger protein","GO:0005829,cellular_component,cytosol;GO:0046872,molecular_function,metal ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["RAD18",2.652426082,0.422307175,2.636884838,3.547344017,{"v":3.24e-08,"d":"3.24E-08"},{"v":2.14e-07,"d":"2.14E-07"},"ENSG00000070950","A0A024R2I7,RAD18 homolog","-","PF02037,SAP domain;PF13923,Zinc finger, C3HC4 type (RING finger)","IPR017907,Zinc finger, RING-type, conserved site;IPR036361,SAP domain superfamily;IPR006642,Zinc finger, Rad18-type putative;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR003034,SAP domain","COG5432,RING-finger-containing E3 ubiquitin ligase;KOG0287,Postreplication repair protein RAD18","GO:0006281,biological_process,DNA repair;GO:0003677,molecular_function,DNA binding","-"]
["RP11-552F3.4",9.33832032,1.472644697,2.633317198,2.49600074,{"v":5.25e-05,"d":"5.25E-05"},1.69653E-4,"ENSG00000266980","F6SJ14,Unkempt family zinc finger","XP_001492089.3,RING finger protein unkempt homolog isoform X4","PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type","KOG1100,Predicted E3 ubiquitin ligase;KOG1595,CCCH-type Zn-finger protein;ENOG410XR0Z,-","GO:0048667,biological_process,cell morphogenesis involved in neuron differentiation;GO:0046872,molecular_function,metal ion binding;GO:0005844,cellular_component,polysome;GO:1990715,molecular_function,mRNA CDS binding;GO:2000766,biological_process,negative regulation of cytoplasmic translation;GO:0001764,biological_process,neuron migration","-"]
["C2orf47",5.117675545,0.80705282,2.633317198,2.49600074,{"v":5.25e-05,"d":"5.25E-05"},1.69653E-4,"ENSG00000162972","A0A024R3U8,Uncharacterized protein","NP_078796.2,m-AAA protease-interacting protein 1, mitochondrial precursor","-","-","ENOG4111MUA,-;ENOG410IHVH,-","-","-"]
["TOX",2.011886973,0.317272762,2.633317198,2.49600074,{"v":5.25e-05,"d":"5.25E-05"},1.69653E-4,"ENSG00000198846","H2QW77,Thymocyte selection-associated high mobility group box","XP_519777.2,-","PF00505,HMG (high mobility group) box","IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily","KOG0381,HMG box-containing protein;COG5648,Chromatin-associated proteins containing the HMG domain","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["SDC3",10.95401264,1.761880701,2.63292993,5.52509733,{"v":3.8e-18,"d":"3.80E-18"},{"v":2.21e-16,"d":"2.21E-16"},"ENSG00000162512","G1QK95,Syndecan","-","PF01034,Syndecan domain","IPR031194,Syndecan-3;IPR030479,Syndecan, conserved site;IPR001050,Syndecan;IPR003585,Neurexin/syndecan/glycophorin C;IPR027789,Syndecan/Neurexin domain","ENOG410Y2QY,-;ENOG410IJZ0,-","GO:0031012,cellular_component,extracellular matrix;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["STIL",10.87802613,1.752691587,2.630517989,5.559617579,{"v":2.2e-18,"d":"2.20E-18"},1.35E-16,"ENSG00000123473","H2R409,SCL/TAL1 interrupting locus","-","PF15253,SCL-interrupting locus protein N-terminus","IPR026123,SCL-interrupting locus protein","ENOG4111HAF,-;ENOG410IF1P,-","-","-"]
["HMGA2",25.52970204,4.126904392,2.62839007,7.842871383,{"v":1.4e-28,"d":"1.40E-28"},3.46E-26,"ENSG00000149948","F5H6H0,High mobility group protein HMGI-C","NP_001287848.1,high mobility group protein HMGI-C isoform d","PF02178,AT hook motif","IPR000637,HMG-I/HMG-Y, DNA-binding, conserved site;IPR000116,High mobility group protein HMGA;IPR017956,AT hook, DNA-binding motif","ENOG410IZGR,-;ENOG410YWK3,-","GO:0019899,molecular_function,enzyme binding;GO:0003677,molecular_function,DNA binding;GO:0000785,cellular_component,chromatin;GO:0046426,biological_process,negative regulation of JAK-STAT cascade;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0033144,biological_process,negative regulation of intracellular steroid hormone receptor signaling pathway;GO:0051091,biological_process,positive regulation of DNA binding transcription factor activity;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction","-"]
["ZFP1",4.356487643,0.696970902,2.628201982,3.383984231,{"v":2.18e-07,"d":"2.18E-07"},{"v":1.19E-6,"d":"1.19E-06"},"ENSG00000184517","H2PYS1,Zinc finger protein 1 homolog","XP_523420.3,-;XP_009429530.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13465,Zinc-finger double domain","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF275",3.005086001,0.483101283,2.626463191,3.925058397,{"v":8.89e-10,"d":"8.89E-10"},{"v":8.26e-09,"d":"8.26E-09"},"ENSG00000063587","A6NFS0,Zinc finger protein 275","NP_001073954.3,zinc finger protein 275","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["ZSWIM6",6.6476754,1.072158155,2.625294412,4.477636485,1.57E-12,{"v":2.71e-11,"d":"2.71E-11"},"ENSG00000130449","I3LGU4,Zinc finger SWIM-type containing 6","-","-","IPR007527,Zinc finger, SWIM-type","KOG3615,Uncharacterized conserved protein;ENOG410XPZG,-","GO:0008270,molecular_function,zinc ion binding","-"]
["TBC1D22B",15.22708037,2.460788438,2.624571313,4.986503772,3.08E-15,{"v":9.99e-14,"d":"9.99E-14"},"ENSG00000065491","G3QG54,TBC1 domain family member 22B","XP_004043989.1,TBC1 domain family member 22B isoform X1","PF00566,Rab-GTPase-TBC domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain","-","-","-"]
["DTX2",10.8321764,1.754643597,2.621380003,5.036444064,{"v":1.44e-15,"d":"1.44E-15"},{"v":5.04e-14,"d":"5.04E-14"},"ENSG00000091073","H2QUT5,Deltex homolog 2","XP_016812277.1,probable E3 ubiquitin-protein ligase DTX2 isoform X2;XP_009451489.2,-;XP_009451490.2,-","PF02825,WWE domain;PF00097,Zinc finger, C3HC4 type (RING finger)","IPR037197,WWE domain superfamily;IPR004170,WWE domain;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR018957,Zinc finger, C3HC4 RING-type;IPR018123,WWE domain, subgroup","ENOG410IEMS,-;ENOG4111EY2,-","GO:0031965,cellular_component,nuclear membrane;GO:0007219,biological_process,Notch signaling pathway;GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["GPHN",5.731932923,0.927297913,2.620471015,4.395021689,4.46E-12,{"v":6.92e-11,"d":"6.92E-11"},"ENSG00000171723","E2R034,Gephyrin","-","PF03453,MoeA N-terminal region (domain I and II);PF00994,Probable molybdopterin binding domain;PF03454,MoeA C-terminal region (domain IV)","IPR036688,MoeA, C-terminal, domain IV superfamily;IPR008284,Molybdenum cofactor biosynthesis, conserved site;IPR036425,MoaB/Mog-like domain superfamily;IPR036135,MoeA, N-terminal and linker domain superfamily;IPR001453,MoaB/Mog domain;IPR005110,MoeA, N-terminal and linker domain;IPR005111,MoeA, C-terminal, domain IV","COG0303,Molybdopterin biosynthesis enzyme;COG0521,Molybdopterin biosynthesis enzymes;KOG2371,Molybdopterin biosynthesis protein","GO:0045211,cellular_component,postsynaptic membrane;GO:0061599,molecular_function,molybdopterin molybdotransferase activity;GO:0072579,biological_process,glycine receptor clustering;GO:0018315,biological_process,molybdenum incorporation into molybdenum-molybdopterin complex;GO:0008940,molecular_function,nitrate reductase activity;GO:0005737,cellular_component,cytoplasm;GO:0010038,biological_process,response to metal ion;GO:0030425,cellular_component,dendrite;GO:0043546,molecular_function,molybdopterin cofactor binding;GO:0032324,biological_process,molybdopterin cofactor biosynthetic process;GO:0006777,biological_process,Mo-molybdopterin cofactor biosynthetic process;GO:0097112,biological_process,gamma-aminobutyric acid receptor clustering;GO:0055114,biological_process,oxidation-reduction process;GO:0061598,molecular_function,molybdopterin adenylyltransferase activity","-"]
["ARHGAP21",57.79637074,9.40717946,2.618740758,8.526266691,3.94E-30,1.08E-27,"ENSG00000107863","K7CIL6,Rho GTPase activating protein 21","-","PF00595,PDZ domain (Also known as DHR or GLGF);PF00620,RhoGAP domain;PF15410,Pleckstrin homology domain","IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR000198,Rho GTPase-activating protein domain;IPR008936,Rho GTPase activation protein","ENOG410YY7B,-;ENOG410IPXX,-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0007165,biological_process,signal transduction;GO:0005096,molecular_function,GTPase activator activity","-"]
["RP5-1047A19.4",41.65018494,6.717473817,2.618303914,3.532200288,{"v":4.62e-08,"d":"4.62E-08"},{"v":2.93e-07,"d":"2.93E-07"},"ENSG00000255164","H2REU4,Uncharacterized protein","-","-","-","-","-","-"]
["C16orf52",2.327280091,0.374656014,2.616998046,3.199239568,{"v":6.09e-07,"d":"6.09E-07"},{"v":3.02e-06,"d":"3.02E-06"},"ENSG00000185716","G3PCD0,Chromosome 16 open reading frame 52","-","-","IPR037663,Uncharacterized protein C16orf52","ENOG410Z2QM,-;ENOG410IJ25,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP5-1187M17.10",2.640891328,0.425142561,2.616998046,3.199239568,{"v":6.09e-07,"d":"6.09E-07"},{"v":3.02e-06,"d":"3.02E-06"},"ENSG00000088899","K6ZHY0,ProSAPiP1 protein","-","PF06818,ez1","IPR033295,Leucine zipper putative tumor suppressor 3","ENOG410Z2V9,-;ENOG410IFZY,-","GO:0014069,cellular_component,postsynaptic density","-"]
["B3GLCT",2.236265056,0.358807978,2.614666043,2.762589761,{"v":2.16E-5,"d":"2.16E-05"},{"v":7.65e-05,"d":"7.65E-05"},"ENSG00000187676","K6ZXU9,Beta 1,3-galactosyltransferase-like","-","PF02434,ringe-like","IPR029044,Nucleotide-diphospho-sugar transferases;IPR003378,Fringe-like","ENOG410XWFG,-;ENOG410IE18,-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane","-"]
["WDR35",1.303061032,0.209075705,2.614666043,2.762589761,{"v":2.16E-5,"d":"2.16E-05"},{"v":7.65e-05,"d":"7.65E-05"},"ENSG00000118965","H2R3M3,WD repeat-containing protein 35","XP_515315.5,WD repeat-containing protein 35 isoform X1","PF12894,Anaphase-promoting complex subunit 4 WD40 domain","IPR017986,WD40-repeat-containing domain;IPR017233,WD repeat protein 35;IPR024977,Anaphase-promoting complex subunit 4, WD40 domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR001680,WD40 repeat","KOG2041,WD40 repeat protein;ENOG410XNSQ,-","GO:0005930,cellular_component,axoneme;GO:0005737,cellular_component,cytoplasm;GO:0042995,cellular_component,cell projection;GO:0005929,cellular_component,cilium;GO:0030991,cellular_component,intraciliary transport particle A;GO:0005856,cellular_component,cytoskeleton;GO:0005815,cellular_component,microtubule organizing center;GO:0030030,biological_process,cell projection organization;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0036064,cellular_component,ciliary basal body;GO:0005813,cellular_component,centrosome;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0035721,biological_process,intraciliary retrograde transport;GO:0060271,biological_process,cilium assembly;GO:0061512,biological_process,protein localization to cilium","-"]
["CSNK1G1",7.041651755,1.147091962,2.614208217,5.352978365,{"v":4.99e-17,"d":"4.99E-17"},{"v":2.35e-15,"d":"2.35E-15"},"ENSG00000169118","U3KQB3,Casein kinase I isoform gamma-1","NP_001316534.1,casein kinase I isoform gamma-1 isoform 2","PF00069,Protein kinase domain;PF12605,Casein kinase 1 gamma C terminal","IPR022247,Casein kinase 1 gamma C-terminal;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["FIGN",2.030186316,0.32957498,2.610315507,3.666380875,{"v":1.05E-8,"d":"1.05E-08"},{"v":7.73e-08,"d":"7.73E-08"},"ENSG00000182263","G3QL88,Fidgetin, microtubule severing factor","-","PF09336,Vps4 C terminal oligomerisation domain;PF00004,ATPase family associated with various cellular activities (AAA)","-","-","-","-"]
["RP11-855A2.2",2.886378578,0.459556024,2.609315671,2.12531608,0.000672116,1.686105E-3,"ENSG00000279880","G1QM82,Bromodomain PHD finger transcription factor","-","PF15612,WSTF, HB1, Itc1p, MBD9 motif 1;PF00439,Bromodomain;PF00628,PHD-finger;PF02791,T domain;PF15613,Williams-Beuren syndrome DDT (WSD), D-TOX E motif","IPR028941,WHIM2 domain;IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR028942,WHIM1 domain;IPR038028,Nucleosome-remodeling factor subunit BPTF;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR018501,DDT domain;IPR036427,Bromodomain-like superfamily;IPR001487,Bromodomain;IPR019787,Zinc finger, PHD-finger;IPR018359,Bromodomain, conserved site;IPR019786,Zinc finger, PHD-type, conserved site","KOG1632,Uncharacterized PHD Zn-finger protein;COG5076,Transcription factor involved in chromatin remodeling, contains bromodomain;KOG1473,Nucleosome remodeling factor, subunit NURF301/BPTF","GO:0035064,molecular_function,methylated histone binding;GO:0016589,cellular_component,NURF complex;GO:0046872,molecular_function,metal ion binding","-"]
["FAM188B",0.841598116,0.133995411,2.609315671,2.12531608,0.000672116,1.686105E-3,"ENSG00000106125","H2QUD5,Family with sequence similarity 188, member B","XP_527714.3,protein FAM188B isoform X1","PF13898,omain of unknown function (DUF4205)","IPR025257,Domain of unknown function DUF4205","ENOG410XSGV,-;KOG2871,Uncharacterized conserved protein","-","-"]
["ZBTB38",4.91825759,0.805182937,2.607143931,5.387714159,3.24E-17,{"v":1.56e-15,"d":"1.56E-15"},"ENSG00000177311","K7CDJ0,Zinc finger and BTB domain containing 38","-","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","-","-","-","-"]
["SLC25A23",27.56277463,4.518100601,2.607043362,6.305370524,{"v":3.94e-22,"d":"3.94E-22"},{"v":4.63e-20,"d":"4.63E-20"},"ENSG00000125648","G3QVW8,Solute carrier family 25 member 23","XP_018871052.1,calcium-binding mitochondrial carrier protein SCaMC-3 isoform X3","PF00153,Mitochondrial carrier protein;PF13499,-hand domain pair;PF13202,hand","IPR023395,Mitochondrial carrier domain superfamily;IPR018247,EF-Hand 1, calcium-binding site;IPR002067,Mitochondrial carrier protein;IPR002048,EF-hand domain;IPR018108,Mitochondrial substrate/solute carrier;IPR011992,EF-hand domain pair","-","GO:0055085,biological_process,transmembrane transport;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005509,molecular_function,calcium ion binding","-"]
["TAB3",13.35724993,2.191125233,2.606389743,6.643486221,1.31E-23,1.92E-21,"ENSG00000157625","H2R4S6,TGF-beta activated kinase 1/MAP3K7 binding protein 3","XP_003317455.1,-","PF02845,CUE domain","IPR003892,Ubiquitin system component Cue;IPR001876,Zinc finger, RanBP2-type;IPR036443,Zinc finger, RanBP2-type superfamily","ENOG410IG4E,-;ENOG410XPAC,-","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0046872,molecular_function,metal ion binding","K12793,ko04621,NOD-like receptor signaling pathway;K12793,ko04668,TNF signaling pathway;K12793,ko04064,NF-kappa B signaling pathway"]
["MBNL2",15.0468837,2.470160446,2.603370131,5.462612311,{"v":9.87e-18,"d":"9.87E-18"},{"v":5.3e-16,"d":"5.30E-16"},"ENSG00000139793","G3QZ59,Muscleblind like splicing regulator 2","XP_004054709.1,-","PF14608,RNA-binding, Nab2-type zinc finger;PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR000571,Zinc finger, CCCH-type","-","GO:0046872,molecular_function,metal ion binding","-"]
["SEMA7A",2.810505317,0.456249866,2.601988005,2.986579851,{"v":5.16e-06,"d":"5.16E-06"},{"v":2.09E-5,"d":"2.09E-05"},"ENSG00000138623","H2NNR6,Semaphorin 7A","XP_002825703.1,semaphorin-7A","PF01437,Plexin repeat;PF13895,Immunoglobulin domain;PF01403,Sema domain","IPR001627,Sema domain;IPR036352,Sema domain superfamily;IPR016201,PSI domain;IPR002165,Plexin repeat;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR027231,Semaphorin;IPR007110,Immunoglobulin-like domain","KOG3611,Semaphorins;ENOG410XQZC,-","GO:0045773,biological_process,positive regulation of axon extension;GO:0050727,biological_process,regulation of inflammatory response;GO:0009897,cellular_component,external side of plasma membrane;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0048675,biological_process,axon extension;GO:0021988,biological_process,olfactory lobe development;GO:0060907,biological_process,positive regulation of macrophage cytokine production;GO:0005178,molecular_function,integrin binding;GO:0016020,cellular_component,membrane;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0031175,biological_process,neuron projection development;GO:0016021,cellular_component,integral component of membrane;GO:0001934,biological_process,positive regulation of protein phosphorylation","K06529,ko04360,Axon guidance"]
["PCDH7",0.988690294,0.16050132,2.601988005,2.986579851,{"v":5.16e-06,"d":"5.16E-06"},{"v":2.09E-5,"d":"2.09E-05"},"ENSG00000169851","K7BAH5,Protocadherin 7","-","PF08374,Protocadherin;PF08266,Cadherin-like;PF00028,Cadherin domain","IPR013585,Protocadherin;IPR020894,Cadherin conserved site;IPR002126,Cadherin;IPR013164,Cadherin, N-terminal;IPR015919,Cadherin-like","ENOG410XPHP,-;ENOG410II7Q,-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ZNF92",5.13865918,0.839684227,2.599480554,3.516890022,{"v":6.58e-08,"d":"6.58E-08"},{"v":4.03E-7,"d":"4.03E-07"},"ENSG00000146757","H2QFX6,Uncharacterized protein","XP_016814196.1,-;XP_003318510.1,zinc finger protein 92 isoform X1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TFPI",21.14315618,3.496493993,2.595198401,7.184695621,{"v":8.87e-26,"d":"8.87E-26"},1.76E-23,"ENSG00000003436","G3RM61,Tissue factor pathway inhibitor","XP_004032983.1,tissue factor pathway inhibitor isoform X2;XP_004032985.1,-","PF00014,Kunitz/Bovine pancreatic trypsin inhibitor domain","IPR008296,Tissue factor pathway inhibitor-like;IPR029864,Tissue factor pathway inhibitor 1;IPR002223,Pancreatic trypsin inhibitor Kunitz domain;IPR020901,Proteinase inhibitor I2, Kunitz, conserved site;IPR036880,Pancreatic trypsin inhibitor Kunitz domain superfamily","-","GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0010466,biological_process,negative regulation of peptidase activity;GO:0005901,cellular_component,caveola;GO:0004867,molecular_function,serine-type endopeptidase inhibitor activity;GO:0071383,biological_process,cellular response to steroid hormone stimulus;GO:0009986,cellular_component,cell surface;GO:0007596,biological_process,blood coagulation;GO:0030414,molecular_function,peptidase inhibitor activity;GO:0005576,cellular_component,extracellular region;GO:0030195,biological_process,negative regulation of blood coagulation;GO:0007599,biological_process,hemostasis;GO:0005615,cellular_component,extracellular space","K03909,ko04610,Complement and coagulation cascades"]
["PPARGC1B",1.086984915,0.177953613,2.59280943,3.179793287,{"v":8.98e-07,"d":"8.98E-07"},{"v":4.28e-06,"d":"4.28E-06"},"ENSG00000155846","H2QRS1,Uncharacterized protein","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034621,Peroxisome proliferator-activated receptor gamma coactivator 1-beta;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034177,PPARGC1B, RNA recognition motif;IPR000504,RNA recognition motif domain;IPR034605,PGC-1;IPR035979,RNA-binding domain superfamily","ENOG4111PZ5,-;ENOG410IIJJ,-","GO:0030331,molecular_function,estrogen receptor binding;GO:0003712,molecular_function,transcription cofactor activity;GO:0003676,molecular_function,nucleic acid binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0003723,molecular_function,RNA binding;GO:0008134,molecular_function,transcription factor binding;GO:0051091,biological_process,positive regulation of DNA binding transcription factor activity;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component,nucleus;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity","K17962,ko04931,Insulin resistance"]
["FLVCR2",1.643322805,0.266772599,2.59167202,2.463624732,{"v":8.22e-05,"d":"8.22E-05"},0.00025344,"ENSG00000119686","G3RS74,Feline leukemia virus subgroup C cellular receptor family member 2","XP_004055519.1,feline leukemia virus subgroup C receptor-related protein 2 isoform X1","-","IPR036259,MFS transporter superfamily;IPR020846,Major facilitator superfamily domain;IPR011701,Major facilitator superfamily","-","GO:0055085,biological_process,transmembrane transport;GO:0015232,molecular_function,heme transporter activity;GO:0020037,molecular_function,heme binding;GO:0015886,biological_process,heme transport;GO:0016021,cellular_component,integral component of membrane","-"]
["NPIPB4",1.038678109,0.168616207,2.59167202,2.463624732,{"v":8.22e-05,"d":"8.22E-05"},0.00025344,"ENSG00000185864","A0A067ZXQ4,Nuclear pore complex-interacting protein B type","-","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);ENOG410J0WZ,-","-","-"]
["C6orf136",7.511723198,1.237633409,2.585856994,3.349720966,{"v":4.53e-07,"d":"4.53E-07"},{"v":2.3E-6,"d":"2.30E-06"},"ENSG00000204564","H2QSM3,Chromosome 6 open reading frame 136","XP_009449167.1,uncharacterized protein C6orf136 homolog","PF10184,Uncharacterized conserved protein (DUF2358)","IPR018790,Protein of unknown function DUF2358","KOG4457,Uncharacterized conserved protein;ENOG4111RAP,-","-","-"]
["EYA1",15.24889134,2.535113695,2.585427913,5.557179597,{"v":5.84e-18,"d":"5.84E-18"},{"v":3.27e-16,"d":"3.27E-16"},"ENSG00000104313","A0A024R813,Eyes absent homolog","XP_016868695.1,-;NP_742055.1,-;NP_000494.2,eyes absent homolog 1 isoform 1","-","IPR028471,Eyes absent homologue 1;IPR028472,Eyes absent family;IPR006545,EYA domain;IPR038102,EYA domain superfamily","KOG3107,Predicted haloacid dehalogenase-like hydrolase (eyes absent);ENOG410XT12,-","GO:0042474,biological_process,middle ear morphogenesis;GO:0032991,cellular_component,protein-containing complex;GO:0060037,biological_process,pharyngeal system development;GO:0071600,biological_process,otic vesicle morphogenesis;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0072513,biological_process,positive regulation of secondary heart field cardioblast proliferation;GO:0007501,biological_process,mesodermal cell fate specification;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0009887,biological_process,animal organ morphogenesis;GO:0071599,biological_process,otic vesicle development;GO:0005634,cellular_component,nucleus;GO:0042472,biological_process,inner ear morphogenesis;GO:0016787,molecular_function,hydrolase activity;GO:0045165,biological_process,cell fate commitment;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0048704,biological_process,embryonic skeletal system morphogenesis;GO:0005737,cellular_component,cytoplasm;GO:0042471,biological_process,ear morphogenesis;GO:0001657,biological_process,ureteric bud development;GO:0006470,biological_process,protein dephosphorylation;GO:0045664,biological_process,regulation of neuron differentiation;GO:0001658,biological_process,branching involved in ureteric bud morphogenesis;GO:0001656,biological_process,metanephros development;GO:0090103,biological_process,cochlea morphogenesis;GO:0014706,biological_process,striated muscle tissue development;GO:0042473,biological_process,outer ear morphogenesis;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0035909,biological_process,aorta morphogenesis;GO:0048665,biological_process,neuron fate specification;GO:0048752,biological_process,semicircular canal morphogenesis;GO:0016604,cellular_component,nuclear body;GO:2001240,biological_process,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0005654,cellular_component,nucleoplasm;GO:0016925,biological_process,protein sumoylation;GO:0032993,cellular_component,protein-DNA complex;GO:0003151,biological_process,outflow tract morphogenesis;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0046872,molecular_function,metal ion binding;GO:0003723,molecular_function,RNA binding;GO:0048856,biological_process,anatomical structure development;GO:0050679,biological_process,positive regulation of epithelial cell proliferation;GO:0007389,biological_process,pattern specification process;GO:0007275,biological_process,multicellular organism development","K15616,ko05202,Transcriptional misregulation in cancer"]
["ATMIN",30.79170201,5.127917218,2.584808632,6.828106215,{"v":3.34e-24,"d":"3.34E-24"},{"v":5.43e-22,"d":"5.43E-22"},"ENSG00000166454","G1RHM9,ATM interactor","-","-","IPR013087,Zinc finger C2H2-type","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["STXBP1",3.987957372,0.661735274,2.584692392,4.518339421,{"v":1.26e-12,"d":"1.26E-12"},2.25E-11,"ENSG00000136854","A0A096P203,Syntaxin binding protein 1","XP_003911968.1,-","PF00995,Sec1 family","IPR027482,Sec1-like, domain 2;IPR036045,Sec1-like superfamily;IPR001619,Sec1-like protein","-","GO:0006887,biological_process,exocytosis;GO:0019905,molecular_function,syntaxin binding;GO:0007412,biological_process,axon target recognition;GO:0005886,cellular_component,plasma membrane;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0002576,biological_process,platelet degranulation;GO:0060292,biological_process,long term synaptic depression;GO:0007274,biological_process,neuromuscular synaptic transmission;GO:0045956,biological_process,positive regulation of calcium ion-dependent exocytosis;GO:0099525,biological_process,presynaptic dense core vesicle exocytosis;GO:0031091,cellular_component,platelet alpha granule;GO:0016188,biological_process,synaptic vesicle maturation;GO:0005739,cellular_component,mitochondrion;GO:0006904,biological_process,vesicle docking involved in exocytosis;GO:0005829,cellular_component,cytosol;GO:0048787,cellular_component,presynaptic active zone membrane;GO:0045335,cellular_component,phagocytic vesicle;GO:0030424,cellular_component,axon;GO:0070527,biological_process,platelet aggregation;GO:0005654,cellular_component,nucleoplasm;GO:0043209,cellular_component,myelin sheath;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0017075,molecular_function,syntaxin-1 binding;GO:0072659,biological_process,protein localization to plasma membrane;GO:0007269,biological_process,neurotransmitter secretion;GO:0032229,biological_process,negative regulation of synaptic transmission, GABAergic;GO:0016192,biological_process,vesicle-mediated transport","-"]
["RP11-131M11.3",0.619820565,0.095030001,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000279179","F7I4T2,Latent transforming growth factor beta binding protein 4","-","-","-","-","-","-"]
["SZT2-AS1",3.057426763,0.468760293,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000229372","H2R1G4,Uncharacterized protein","-","-","IPR033228,Protein SZT2","ENOG410XTCX,-;ENOG410IE3I,-","GO:0005777,cellular_component,peroxisome","-"]
["GBP4",0.348807134,0.05347861,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000162654","D3DT27,Guanylate binding protein 4, isoform CRA_a","-","PF02841,uanylate-binding protein, C-terminal domain;PF02263,uanylate-binding protein, N-terminal domain","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR003191,Guanylate-binding protein/Atlastin, C-terminal;IPR030386,GB1/RHD3-type guanine nucleotide-binding (G) domain;IPR015894,Guanylate-binding protein, N-terminal;IPR036543,Guanylate-binding protein, C-terminal domain superfamily;IPR037684,Guanylate-binding protein, C-terminal","ENOG410XR6Z,-;KOG2037,Guanylate-binding protein","GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding","-"]
["RP11-101E13.5",3.092823889,0.47418733,2.584337397,0.919397882,0.043331447,0.069255435,"-","-","-","-","-","-","-","-"]
["RYR2",0.120219458,0.018431875,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000198626","H2R0U9,Uncharacterized protein","-","PF02026,RyR domain;PF00622,SPRY domain;PF08709,Inositol 1,4,5-trisphosphate/ryanodine receptor;PF01365,RIH domain;PF06459,Ryanodine Receptor TM 4-6;PF08454,RyR and IP3R Homology associated;PF13833,-hand domain pair;PF02815,MIR domain;PF00520,Ion transport protein","IPR015925,Ryanodine receptor-related;IPR036300,Mir domain superfamily;IPR035910,RyR/IP3 receptor binding core, RIH domain superfamily;IPR009460,Ryanodine Receptor TM 4-6;IPR001870,B30.2/SPRY domain;IPR011992,EF-hand domain pair;IPR035764,Ryanodine receptor, SPRY domain 2;IPR013662,RyR/IP3R Homology associated domain;IPR002048,EF-hand domain;IPR016093,MIR motif;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000699,RIH domain;IPR035762,Ryanodine receptor, SPRY domain 3;IPR005821,Ion transport domain;IPR013333,Ryanodine receptor;IPR035761,Ryanodine receptor, SPRY domain 1;IPR003877,SPRY domain;IPR014821,Inositol 1,4,5-trisphosphate/ryanodine receptor;IPR003032,Ryanodine receptor Ryr","KOG2243,Ca2+ release channel (ryanodine receptor);ENOG410YCNW,-","GO:0005216,molecular_function,ion channel activity;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0005262,molecular_function,calcium channel activity;GO:0055085,biological_process,transmembrane transport;GO:0006816,biological_process,calcium ion transport;GO:0005509,molecular_function,calcium ion binding;GO:0006811,biological_process,ion transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0005219,molecular_function,ryanodine-sensitive calcium-release channel activity;GO:0051209,biological_process,release of sequestered calcium ion into cytosol;GO:0016021,cellular_component,integral component of membrane;GO:0070588,biological_process,calcium ion transmembrane transport","-"]
["CTSF",0.737963159,0.113143455,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000174080","G3RIV1,Cathepsin F","-","PF08246,Cathepsin propeptide inhibitor domain (I29);PF00112,Papain family cysteine protease","IPR025660,Cysteine peptidase, histidine active site;IPR013201,Cathepsin propeptide inhibitor domain (I29);IPR013128,Peptidase C1A;IPR000169,Cysteine peptidase, cysteine active site;IPR000668,Peptidase C1A, papain C-terminal","-","GO:0006508,biological_process,proteolysis;GO:0008234,molecular_function,cysteine-type peptidase activity","-"]
["LINC00987",0.864539364,0.132549937,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000237248","F7FF95,Uncharacterized protein","XP_001118453.3,alpha-2-macroglobulin-like isoform X1","PF07678,A-macroglobulin complement component;PF07677,A-macroglobulin receptor","IPR001599,Alpha-2-macroglobulin;IPR008930,Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid;IPR009048,Alpha-macroglobulin, receptor-binding;IPR036595,Alpha-macroglobulin, receptor-binding domain superfamily;IPR002890,Alpha-2-macroglobulin, N-terminal;IPR013783,Immunoglobulin-like fold;IPR019565,Alpha-2-macroglobulin, thiol-ester bond-forming;IPR014756,Immunoglobulin E-set;IPR011625,Alpha-2-macroglobulin, N-terminal 2;IPR019742,Alpha-2-macroglobulin, conserved site;IPR011626,Alpha-macroglobulin complement component","ENOG410XRED,-;KOG1366,Alpha-macroglobulin","GO:0004866,molecular_function,endopeptidase inhibitor activity;GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space","-"]
["RP5-1057I20.4",1.978834544,0.303392079,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000268069","Q6ZVP1,cDNA FLJ42272 fis, clone TKIDN2016309","-","-","-","ENOG410KCH5,-;ENOG4110NZ1,-","-","-"]
["RP3-521E19.2",2.84572744,0.436302856,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000257494","U3F3B7,Putative E3 ubiquitin-protein ligase HECTD4","-","PF00632,HECT-domain (ubiquitin-transferase)","IPR000569,HECT domain;IPR035781,HECTD4, SPRY domain;IPR035983,HECT, E3 ligase catalytic domain","KOG1426,FOG: RCC1 domain;COG5184,Alpha-tubulin suppressor and related RCC1 domain-containing proteins","GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016874,molecular_function,ligase activity;GO:0016740,molecular_function,transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["RP6-114E22.1",5.383227475,0.825348728,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000266869","Q96AZ4,Secretory carrier-associated membrane protein","-","PF04144,SCAMP family","IPR007273,SCAMP","-","GO:0015031,biological_process,protein transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GOLGA8A",0.316613527,0.048542733,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000175265","C9J1B5,Golgin subfamily A member 8B","-","PF15070,Putative golgin subfamily A member 2-like protein 5","IPR024858,Golgin subfamily A","ENOG410ZIE4,-;KOG4725,Uncharacterized conserved protein","GO:0005829,cellular_component,cytosol;GO:0005794,cellular_component,Golgi apparatus","-"]
["RP11-485O10.2",5.263894846,0.80705282,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000259670","A0A075B719,Centrosomal protein of 152 kDa","-","-","IPR029598,Centrosomal protein of 152kDa","ENOG410XQAW,-;ENOG410IGHC,-","GO:0098535,biological_process,de novo centriole assembly involved in multi-ciliated epithelial cell differentiation;GO:0005815,cellular_component,microtubule organizing center;GO:0007099,biological_process,centriole replication;GO:0098536,cellular_component,deuterosome","-"]
["RP11-400F19.8",3.597880989,0.551621961,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000266929","K7ENX5,Alpha-N-acetylglucosaminidase","-","PF05089,Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain","IPR024733,Alpha-N-acetylglucosaminidase, tim-barrel domain;IPR007781,Alpha-N-acetylglucosaminidase","KOG2233,Alpha-N-acetylglucosaminidase;ENOG410XNMK,-","-","-"]
["RP11-1072C15.6",0.613592107,0.094075063,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000279879","H2PFS8,Uncharacterized protein","-","-","-","-","-","-"]
["RP11-159D12.3",3.67838435,0.563964621,2.584337397,0.919397882,0.043331447,0.069255435,"-","-","-","-","-","-","-","-"]
["ROCK1P1",0.807992933,0.12388032,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000263006","H9EPT5,Rho-associated protein kinase","NP_001248063.1,rho-associated protein kinase 1","PF00069,Protein kinase domain;PF08912,Rho Binding","IPR029876,Rho-associated protein kinase 1;IPR037310,Rho-associated protein kinase 1, HR1;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR020684,Rho-associated protein kinase 1/2;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR015008,Rho binding domain;IPR000719,Protein kinase domain","ENOG410XR1Q,-;KOG0612,Rho-associated, coiled-coil containing protein kinase","GO:0030036,biological_process,actin cytoskeleton organization;GO:0016301,molecular_function,kinase activity;GO:0051492,biological_process,regulation of stress fiber assembly;GO:0035556,biological_process,intracellular signal transduction;GO:0017048,molecular_function,Rho GTPase binding;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:2000114,biological_process,regulation of establishment of cell polarity;GO:0005524,molecular_function,ATP binding;GO:0005856,cellular_component,cytoskeleton;GO:0017049,molecular_function,GTP-Rho binding;GO:0004672,molecular_function,protein kinase activity;GO:0007266,biological_process,Rho protein signal transduction;GO:0051493,biological_process,regulation of cytoskeleton organization;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity","K04514,ko04071,Sphingolipid signaling pathway;K04514,ko04611,Platelet activation;K04514,ko05131,Shigellosis;K04514,ko04510,Focal adhesion;K04514,ko04062,Chemokine signaling pathway;K04514,ko04350,TGF-beta signaling pathway;K04514,ko04921,Oxytocin signaling pathway;K04514,ko04670,Leukocyte transendothelial migration;K04514,ko05132,Salmonella infection;K04514,ko04024,cAMP signaling pathway;K04514,ko05205,Proteoglycans in cancer;K04514,ko04270,Vascular smooth muscle contraction;K04514,ko04022,cGMP-PKG signaling pathway;K04514,ko04810,Regulation of actin cytoskeleton;K04514,ko05206,MicroRNAs in cancer;K04514,ko05200,Pathways in cancer;K04514,ko05130,Pathogenic Escherichia coli infection;K04514,ko04360,Axon guidance"]
["ABHD3",0.489496406,0.075048888,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000158201","H2QEB8,Abhydrolase domain containing 3","XP_003315914.1,phospholipase ABHD3 isoform X1","PF12697,Alpha/beta hydrolase family;PF00561,alpha/beta hydrolase fold","IPR012020,AB hydrolase 4 family;IPR000952,AB hydrolase 4, conserved site;IPR000073,Alpha/beta hydrolase fold-1;IPR029058,Alpha/Beta hydrolase fold","KOG1838,Alpha/beta hydrolase;COG0429,Predicted hydrolase of the alpha/beta-hydrolase fold","GO:0004623,molecular_function,phospholipase A2 activity;GO:0046470,biological_process,phosphatidylcholine metabolic process;GO:0008970,molecular_function,phosphatidylcholine 1-acylhydrolase activity;GO:0016787,molecular_function,hydrolase activity;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ZNF253",0.589393631,0.090364988,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000256771","A0A1W2PRC0,Zinc finger protein 253","-","-","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF724P",0.643329713,0.09863439,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000196081","H2QFW5,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF571",0.344366953,0.052797848,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000180479","Q24JS6,Zinc finger protein 571","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF813",0.34227119,0.052476529,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000198346","H2RBR4,Zinc finger protein 845","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["CYCSP6",7.076626846,1.084978295,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000214429","A0A091DK93,Cytochrome c, somatic","XP_010626552.1,-;XP_010626551.1,cytochrome c","PF00034,Cytochrome c","IPR036909,Cytochrome c-like domain superfamily;IPR009056,Cytochrome c-like domain;IPR002327,Cytochrome c, class IA/ IB","-","GO:0022900,biological_process,electron transport chain;GO:0046872,molecular_function,metal ion binding;GO:0009055,molecular_function,electron transfer activity;GO:0005739,cellular_component,mitochondrion;GO:0070469,cellular_component,respiratory chain;GO:0055114,biological_process,oxidation-reduction process;GO:0020037,molecular_function,heme binding","-"]
["DNAH6",0.158142764,0.024246222,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000115423","G3QN60,Dynein axonemal heavy chain 6","XP_004029568.2,dynein heavy chain 6, axonemal","PF12774,Hydrolytic ATP binding site of dynein motor region D1;PF12777,Microtubule-binding stalk of dynein motor;PF07728,AAA domain (dynein-related subfamily);PF03028,ynein heavy chain and region D6 of dynein motor;PF12780,P-loop containing dynein motor region D4;PF08393,ynein heavy chain, N-terminal region 2;PF12781,ATP-binding dynein motor region D5;PF12775,P-loop containing dynein motor region D3","IPR035699,Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;IPR024743,Dynein heavy chain, coiled coil stalk;IPR026983,Dynein heavy chain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004273,Dynein heavy chain domain;IPR013602,Dynein heavy chain, domain-2;IPR035706,Dynein heavy chain, ATP-binding dynein motor region D5;IPR011704,ATPase, dynein-related, AAA domain;IPR003593,AAA+ ATPase domain;IPR026980,Dynein heavy chain 6, axonemal;IPR024317,Dynein heavy chain, AAA module D4","-","GO:0005858,cellular_component,axonemal dynein complex;GO:0005524,molecular_function,ATP binding;GO:0016887,molecular_function,ATPase activity;GO:0001539,biological_process,cilium or flagellum-dependent cell motility;GO:0007018,biological_process,microtubule-based movement;GO:0030286,cellular_component,dynein complex;GO:0003777,molecular_function,microtubule motor activity","-"]
["TUBB1",0.611310443,0.093725242,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000101162","H2QKN9,Tubulin beta chain","XP_001140173.1,tubulin beta-1 chain","PF03953,Tubulin C-terminal domain;PF00091,Tubulin/FtsZ family, GTPase domain","IPR017975,Tubulin, conserved site;IPR018316,Tubulin/FtsZ, 2-layer sandwich domain;IPR003008,Tubulin/FtsZ, GTPase domain;IPR008280,Tubulin/FtsZ, C-terminal;IPR036525,Tubulin/FtsZ, GTPase domain superfamily;IPR037103,Tubulin/FtsZ, C-terminal domain superfamily;IPR013838,Beta tubulin, autoregulation binding site;IPR000217,Tubulin;IPR023123,Tubulin, C-terminal;IPR002453,Beta tubulin","KOG1375,Beta tubulin;COG5023,Tubulin","GO:0051225,biological_process,spindle assembly;GO:0005874,cellular_component,microtubule;GO:0005737,cellular_component,cytoplasm;GO:0005525,molecular_function,GTP binding;GO:0007017,biological_process,microtubule-based process;GO:0005856,cellular_component,cytoskeleton;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005200,molecular_function,structural constituent of cytoskeleton","K07375,ko04540,Gap junction;K07375,ko05130,Pathogenic Escherichia coli infection;K07375,ko04145,Phagosome"]
["TTC38",0.597300533,0.091577262,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000075234","G3QFK0,Tetratricopeptide repeat domain 38","XP_004063701.2,tetratricopeptide repeat protein 38 isoform X2","-","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR033891,Tetratricopeptide repeat protein 38","-","-","-"]
["UBA7",0.470218109,0.072093167,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000182179","K7BL13,Ubiquitin-like modifier activating enzyme 7","XP_016796602.1,ubiquitin-like modifier-activating enzyme 7 isoform X1","PF16191,Ubiquitin-activating enzyme E1 four-helix bundle;PF16190,Ubiquitin-activating enzyme E1 FCCH domain;PF00899,ThiF family;PF09358,Ubiquitin fold domain;PF10585,Ubiquitin-activating enzyme active site","IPR032420,Ubiquitin-activating enzyme E1, four-helix bundle;IPR033127,Ubiquitin-activating enzyme E1, Cys active site;IPR000594,THIF-type NAD/FAD binding fold;IPR035985,Ubiquitin-activating enzyme;IPR018075,Ubiquitin-activating enzyme E1;IPR018965,Ubiquitin-activating enzyme E1, C-terminal;IPR019572,Ubiquitin-activating enzyme, catalytic cysteine domain;IPR000011,Ubiquitin/SUMO-activating enzyme E1;IPR032418,Ubiquitin-activating enzyme E1, FCCH domain;IPR038252,Ubiquitin-activating enzyme E1, C-terminal domain superfamily","COG0476,Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2;KOG2012,Ubiquitin activating enzyme UBA1","GO:0019941,biological_process,modification-dependent protein catabolic process;GO:0032020,biological_process,ISG15-protein conjugation;GO:0016874,molecular_function,ligase activity;GO:0019782,molecular_function,ISG15 activating enzyme activity;GO:0008641,molecular_function,ubiquitin-like modifier activating enzyme activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0006464,biological_process,cellular protein modification process","K10698,ko05012,Parkinson's disease;K10698,ko04120,Ubiquitin mediated proteolysis"]
["RP11-305O4.3",4.868203434,0.74638598,2.584337397,0.919397882,0.043331447,0.069255435,"-","-","-","-","-","-","-","-"]
["FGF2",0.315445211,0.048363608,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000138685","A0A0A0MQV6,Fibroblast growth factor","-","-","IPR028223,Fibroblast growth factor 2;IPR008996,Cytokine IL1/FGF;IPR002209,Fibroblast growth factor family","ENOG4111IPH,-;KOG3885,Fibroblast growth factor","GO:0005104,molecular_function,fibroblast growth factor receptor binding;GO:0008543,biological_process,fibroblast growth factor receptor signaling pathway;GO:0008083,molecular_function,growth factor activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0005576,cellular_component,extracellular region","-"]
["RASGRF2",0.199695506,0.030617029,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000113319","H2QR63,Uncharacterized protein","XP_517672.2,ras-specific guanine nucleotide-releasing factor 2 isoform X1","PF00618,RasGEF N-terminal motif;PF00621,RhoGEF domain;PF00617,RasGEF domain;PF00169,PH domain","IPR000651,Ras-like guanine nucleotide exchange factor, N-terminal;IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR019804,Ras guanine-nucleotide exchange factor, conserved site;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR000048,IQ motif, EF-hand binding site;IPR030744,Ras-specific guanine nucleotide-releasing factor 2;IPR035899,Dbl homology (DH) domain superfamily;IPR000219,Dbl homology (DH) domain","ENOG410IQ6Q,-;ENOG410XPWA,-","GO:0005088,molecular_function,Ras guanyl-nucleotide exchange factor activity;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0046578,biological_process,regulation of Ras protein signal transduction;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005783,cellular_component,endoplasmic reticulum;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","-"]
["HLA-F-AS1",0.511400169,0.078407142,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000214922","Q69YQ6,Uncharacterized protein DKFZp762B162","-","PF00129,Class I Histocompatibility antigen, domains alpha 1 and 2","IPR011161,MHC class I-like antigen recognition-like;IPR037055,MHC class I-like antigen recognition-like superfamily;IPR011162,MHC classes I/II-like antigen recognition protein","-","-","-"]
["RP11-390E23.6",1.01817118,0.156104547,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000272686","G7P0K0,Uncharacterized protein","-","PF00568,WH1 domain;PF00786,P21-Rho-binding domain;PF02205,WH2 motif","IPR000095,CRIB domain;IPR000697,WH1/EVH1 domain;IPR033927,WASP family, EVH1 domain;IPR036936,CRIB domain superfamily;IPR030214,Neural Wiskott-Aldrich syndrome protein;IPR011993,PH-like domain superfamily;IPR003124,WH2 domain;IPR011026,Wiscott-Aldrich syndrome protein, C-terminal","-","GO:2000601,biological_process,positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0007015,biological_process,actin filament organization;GO:0003779,molecular_function,actin binding","-"]
["RP11-180C16.1",0.572806569,0.087821883,2.584337397,0.919397882,0.043331447,0.069255435,"-","-","-","-","-","-","-","-"]
["FAM86B3P",0.438838051,0.067282022,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000173295","Q9HBS9,Uncharacterized protein","-","-","-","-","-","-"]
["CTD-2517M22.16",4.98168137,0.763784254,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000254578","G1SBX8,Uncharacterized protein","-","-","-","-","-","-"]
["MIR4665",27.05242161,4.147638545,2.584337397,0.919397882,0.043331447,0.069255435,"-","-","-","-","-","-","-","-"]
["B4GALT1-AS1",2.535161693,0.388687361,2.584337397,0.919397882,0.043331447,0.069255435,"-","-","-","-","-","-","-","-"]
["PTENP1",0.534820147,0.081997859,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000237984","A0A024QYS4,Mitochondrial PTENalpha","NP_001296406.1,phosphatase and tensin homolog","PF10409,C2 domain of PTEN tumour-suppressor protein;PF00782,ual specificity phosphatase, catalytic domain","IPR014020,Tensin phosphatase, C2 domain;IPR016130,Protein-tyrosine phosphatase, active site;IPR029021,Protein-tyrosine phosphatase-like;IPR000340,Dual specificity phosphatase, catalytic domain;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR029023,Tensin-type phosphatase domain","-","GO:0006470,biological_process,protein dephosphorylation;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0016311,biological_process,dephosphorylation","-"]
["ZXDB",0.362596082,0.055592712,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000198455","H2PVU0,Zinc finger, X-linked, duplicated B","XP_002831772.1,zinc finger X-linked protein ZXDB","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["RP11-366F6.2",1.344959917,0.206207329,2.584337397,0.919397882,0.043331447,0.069255435,"ENSG00000229967","G3SFW4,Uncharacterized protein","-","-","-","-","-","-"]
["ZNF675",3.499781065,0.579507935,2.583879676,3.890067668,{"v":2.3e-09,"d":"2.30E-09"},{"v":1.96E-8,"d":"1.96E-08"},"ENSG00000197372","G3SDL9,Zinc finger protein 675","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["PHF21A",19.14111269,3.191717204,2.58311207,6.978580796,{"v":8.9e-25,"d":"8.90E-25"},1.56E-22,"ENSG00000135365","H2Q3H3,PHD finger protein 21A","-","PF00628,PHD-finger","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019786,Zinc finger, PHD-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger","ENOG410IREA,-;ENOG41112YM,-","GO:0000118,cellular_component,histone deacetylase complex;GO:0003712,molecular_function,transcription cofactor activity;GO:0042393,molecular_function,histone binding;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003682,molecular_function,chromatin binding","-"]
["ATP6V1E2",7.461363641,1.240444615,2.582283448,4.58711435,{"v":1.06e-12,"d":"1.06E-12"},{"v":1.92e-11,"d":"1.92E-11"},"ENSG00000250565","A0A140VKA8,ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2","XP_011531452.1,-;XP_011531455.1,-;XP_016860715.1,-;XP_011531451.1,-;XP_005264691.1,-;XP_005264690.1,-;XP_011531454.1,-;NP_001304992.1,V-type proton ATPase subunit E 2;XP_011531450.1,-;XP_016860714.1,-;XP_011531453.1,-","PF01991,ATP synthase (E/31 kDa) subunit","IPR002842,V-type ATPase subunit E;IPR038495,V-type ATPase subunit E, C-terminal domain superfamily","-","GO:0015991,biological_process,ATP hydrolysis coupled proton transport;GO:0033178,cellular_component,proton-transporting two-sector ATPase complex, catalytic domain;GO:0008553,molecular_function,proton-exporting ATPase activity, phosphorylative mechanism;GO:0001669,cellular_component,acrosomal vesicle;GO:0046961,molecular_function,proton-transporting ATPase activity, rotational mechanism","K02150,ko04966,Collecting duct acid secretion;K02150,ko00190,Oxidative phosphorylation;K02150,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K02150,ko04150,mTOR signaling pathway;K02150,ko04721,Synaptic vesicle cycle;K02150,ko04145,Phagosome;K02150,ko05110,Vibrio cholerae infection;K02150,ko05323,Rheumatoid arthritis"]
["NRG4",1.982374498,0.325644449,2.58083411,2.735921417,{"v":3.27e-05,"d":"3.27E-05"},1.10587E-4,"ENSG00000169752","G3SDI0,Neuregulin 4","XP_004056614.1,pro-neuregulin-4, membrane-bound isoform","PF00008,-like domain","IPR013032,EGF-like, conserved site;IPR000742,EGF-like domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K05458,ko04012,ErbB signaling pathway"]
["MMP16",0.823221304,0.135230477,2.58083411,2.735921417,{"v":3.27e-05,"d":"3.27E-05"},1.10587E-4,"ENSG00000156103","G3S039,Matrix metalloproteinase","-","PF00413,Matrixin;PF01471,Putative peptidoglycan binding domain;PF11857,omain of unknown function (DUF3377);PF00045,Hemopexin","IPR001818,Peptidase M10, metallopeptidase;IPR018486,Hemopexin, conserved site;IPR036375,Hemopexin-like domain superfamily;IPR036365,PGBD-like superfamily;IPR021190,Peptidase M10A;IPR000585,Hemopexin-like domain;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR006026,Peptidase, metallopeptidase;IPR021805,Peptidase M10A, matrix metallopeptidase, C-terminal;IPR018487,Hemopexin-like repeats;IPR033739,Peptidase M10A, catalytic domain;IPR028697,Matrix metalloproteinase-16;IPR021158,Peptidase M10A, cysteine switch, zinc binding site;IPR002477,Peptidoglycan binding-like","-","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0001503,biological_process,ossification;GO:0030574,biological_process,collagen catabolic process;GO:0008237,molecular_function,metallopeptidase activity;GO:0070006,molecular_function,metalloaminopeptidase activity;GO:0016020,cellular_component,membrane;GO:0016485,biological_process,protein processing;GO:0046872,molecular_function,metal ion binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0048701,biological_process,embryonic cranial skeleton morphogenesis;GO:0016021,cellular_component,integral component of membrane;GO:0001958,biological_process,endochondral ossification;GO:0097094,biological_process,craniofacial suture morphogenesis;GO:0008233,molecular_function,peptidase activity;GO:0031012,cellular_component,extracellular matrix;GO:0060348,biological_process,bone development;GO:0035988,biological_process,chondrocyte proliferation;GO:0008270,molecular_function,zinc ion binding;GO:0004222,molecular_function,metalloendopeptidase activity","K07996,ko05206,MicroRNAs in cancer"]
["CCDC169-SOHLH2",8.68333052,1.437821066,2.580408349,3.501409453,{"v":9.38e-08,"d":"9.38E-08"},{"v":5.54e-07,"d":"5.54E-07"},"ENSG00000250709","H2Q7F1,Uncharacterized protein","XP_509628.2,spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2","PF15372,omain of unknown function (DUF4600);PF00010,Helix-loop-helix DNA-binding domain","IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR032669,Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2","ENOG410IUEE,-;ENOG410ZGUF,-","GO:0007283,biological_process,spermatogenesis;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0046983,molecular_function,protein dimerization activity;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030154,biological_process,cell differentiation;GO:0001046,molecular_function,core promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0048477,biological_process,oogenesis","-"]
["MAP2K5",5.097534425,0.846675569,2.58024246,3.995474943,{"v":6.26e-10,"d":"6.26E-10"},{"v":6.06e-09,"d":"6.06E-09"},"ENSG00000137764","H2Q9P0,Mitogen-activated protein kinase kinase 5","XP_001174814.1,-","PF00069,Protein kinase domain;PF00564,PB1 domain","IPR034851,Dual specificity mitogen-activated protein kinase kinase 5, PB1 domain;IPR000270,PB1 domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0581,Mitogen-activated protein kinase kinase (MAP2K);ENOG410XQ5A,-","GO:0032147,biological_process,activation of protein kinase activity;GO:0007346,biological_process,regulation of mitotic cell cycle;GO:0016301,molecular_function,kinase activity;GO:0031098,biological_process,stress-activated protein kinase signaling cascade;GO:0007507,biological_process,heart development;GO:0042981,biological_process,regulation of apoptotic process;GO:0000165,biological_process,MAPK cascade;GO:0005819,cellular_component,spindle;GO:0016310,biological_process,phosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0023014,biological_process,signal transduction by protein phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["KIAA2026",11.37892247,1.900695898,2.579023678,5.748858362,{"v":5.82e-19,"d":"5.82E-19"},{"v":3.87e-17,"d":"3.87E-17"},"ENSG00000183354","K7C0W9,KIAA2026","XP_016816049.1,uncharacterized protein KIAA2026 homolog isoform X1","-","IPR036427,Bromodomain-like superfamily","ENOG410YKW1,-;ENOG410IIP1,-","-","-"]
["RBMS1",14.65329923,2.450861298,2.578431646,6.669148687,{"v":1.99e-23,"d":"1.99E-23"},{"v":2.78e-21,"d":"2.78E-21"},"ENSG00000153250","G1QMS2,RNA binding motif single stranded interacting protein 1","XP_003266209.1,RNA-binding motif, single-stranded-interacting protein 1 isoform X7","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR002343,Paraneoplastic encephalomyelitis antigen;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR035979,RNA-binding domain superfamily;IPR000504,RNA recognition motif domain;IPR034404,MSSP-1, RNA recognition motif 1","ENOG410XRB5,-;KOG4733,FOG: RRM domain","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["R3HDM2",59.33486605,9.935923542,2.577449485,7.683876931,{"v":3.62e-27,"d":"3.62E-27"},{"v":7.82e-25,"d":"7.82E-25"},"ENSG00000179912","B5MCG9,R3H domain-containing protein 2","NP_001317051.1,-;NP_001317050.1,R3H domain-containing protein 2 isoform 1","PF01424,R3H domain","IPR001374,R3H domain;IPR024771,SUZ domain;IPR036867,R3H domain superfamily","ENOG410IS8W,-;ENOG41106PI,-","GO:0003676,molecular_function,nucleic acid binding","-"]
["FOXO1",4.419989867,0.736086045,2.577113649,4.093619566,{"v":1.8E-10,"d":"1.80E-10"},{"v":1.94e-09,"d":"1.94E-09"},"ENSG00000150907","H2Q7G4,Forkhead box O1","XP_522749.3,-","PF00250,orkhead domain;PF16675,KIX-binding domain of forkhead box O, CR2;PF16676,Transactivation domain of FOXO protein family","IPR001766,Fork head domain;IPR032067,FOXO protein, transactivation domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036390,Winged helix DNA-binding domain superfamily;IPR032068,FOXO protein, KIX-binding domain","KOG2294,Transcription factor of the Forkhead/HNF3 family;COG5025,Transcription factor of the Forkhead/HNF3 family","GO:0043565,molecular_function,sequence-specific DNA binding;GO:0008013,molecular_function,beta-catenin binding;GO:0045732,biological_process,positive regulation of protein catabolic process;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0030154,biological_process,cell differentiation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0032873,biological_process,negative regulation of stress-activated MAPK cascade;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005737,cellular_component,cytoplasm;GO:0009267,biological_process,cellular response to starvation;GO:0006351,biological_process,transcription, DNA-templated;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0009653,biological_process,anatomical structure morphogenesis;GO:0071455,biological_process,cellular response to hyperoxia;GO:0010508,biological_process,positive regulation of autophagy","K07201,ko04152,AMPK signaling pathway;K07201,ko04933,AGE-RAGE signaling pathway in diabetic complications;K07201,ko05202,Transcriptional misregulation in cancer;K07201,ko04211,Longevity regulating pathway;K07201,ko04919,Thyroid hormone signaling pathway;K07201,ko05215,Prostate cancer;K07201,ko04068,FoxO signaling pathway;K07201,ko04922,Glucagon signaling pathway;K07201,ko04931,Insulin resistance;K07201,ko04213,Longevity regulating pathway - multiple species;K07201,ko05200,Pathways in cancer;K07201,ko04910,Insulin signaling pathway"]
["NPIPB3",4.178332003,0.694643725,2.576023184,3.638420996,{"v":2.09e-08,"d":"2.09E-08"},{"v":1.43E-7,"d":"1.43E-07"},"ENSG00000169246","B4DHL8,cDNA FLJ54462","-","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);ENOG410J0WZ,-","-","-"]
["NCKAP5L",1.467615237,0.24301368,2.573500627,2.963905617,{"v":5.16e-06,"d":"5.16E-06"},{"v":2.09E-5,"d":"2.09E-05"},"ENSG00000167566","K7CB40,NCK-associated protein 5-like","XP_003313756.2,nck-associated protein 5-like isoform X1;XP_016778935.1,-;XP_016778934.1,-","PF15246,Nck-associated protein 5, Peripheral clock protein","IPR032769,Nck-associated protein 5, C-terminal;IPR026163,Nck-associated protein 5-like","ENOG410XSUM,-;ENOG410IHBY,-","GO:0005813,cellular_component,centrosome;GO:0001578,biological_process,microtubule bundle formation;GO:0007019,biological_process,microtubule depolymerization;GO:0035371,cellular_component,microtubule plus-end","-"]
["RP11-410D17.2",8.108395205,1.352456997,2.572417808,3.763364211,{"v":5e-09,"d":"5.00E-09"},{"v":3.92E-8,"d":"3.92E-08"},"-","-","-","-","-","-","-","-"]
["TMEM41A",3.616144344,0.60482408,2.572007125,4.271717029,{"v":4.06e-11,"d":"4.06E-11"},{"v":5.05e-10,"d":"5.05E-10"},"ENSG00000163900","H2QNW4,Transmembrane protein 41A","XP_526412.3,transmembrane protein 41A","PF09335,SNARE associated Golgi protein","IPR032816,SNARE associated Golgi protein","COG0398,Uncharacterized conserved protein;KOG3140,Predicted membrane protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ARID1A",24.33959032,4.095278581,2.570638151,7.830000945,{"v":1.57e-27,"d":"1.57E-27"},3.72E-25,"ENSG00000117713","A0A0S2Q0B1,AT-rich interactive domain-containing protein 1A","-","PF12031,SWI/SNF-like complex subunit BAF250/Osa;PF01388,ARID/BRIGHT DNA binding domain","IPR001606,ARID DNA-binding domain;IPR021906,SWI/SNF-like complex subunit BAF250/Osa;IPR036431,ARID DNA-binding domain superfamily;IPR033388,SWI/SNF-like complex subunit BAF250, C-terminal;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR030094,SWI/SNF-like  complex subunit BAF250a","-","GO:0070603,cellular_component,SWI/SNF superfamily-type complex;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0006338,biological_process,chromatin remodeling","-"]
["NPAT",3.120328429,0.521895585,2.569401199,3.878206975,{"v":3.17E-9,"d":"3.17E-09"},{"v":2.6e-08,"d":"2.60E-08"},"ENSG00000149308","B9EG70,Nuclear protein, ataxia-telangiectasia locus","-","PF15712,NPAT C terminus","IPR031442,Protein NPAT, C-terminal domain;IPR006594,LIS1 homology motif","ENOG41112YA,-;ENOG410IHIA,-","-","-"]
["SP4",3.771022519,0.630728479,2.569401199,3.878206975,{"v":3.17E-9,"d":"3.17E-09"},{"v":2.6e-08,"d":"2.60E-08"},"ENSG00000105866","H2QU88,Sp4 transcription factor","XP_527679.1,-","PF00096,Zinc finger, C2H2 type","IPR030453,Transcription factor Sp4;IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003713,molecular_function,transcription coactivator activity;GO:0003676,molecular_function,nucleic acid binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["FAM135A",4.776561615,0.804537687,2.564904843,4.936533159,{"v":1.79e-14,"d":"1.79E-14"},{"v":4.81e-13,"d":"4.81E-13"},"ENSG00000082269","G7P2Z7,Uncharacterized protein","-","PF12394,Protein FAM135;PF05057,Putative serine esterase (DUF676)","IPR022122,Protein FAM135;IPR007751,Domain of unknown function DUF676, lipase-like;IPR029058,Alpha/Beta hydrolase fold","-","-","-"]
["ZNF236",4.443571865,0.74774862,2.564811371,4.572596882,1.76E-12,{"v":3.02e-11,"d":"3.02E-11"},"ENSG00000130856","J9JID5,Zinc finger protein 236","NP_001293018.1,zinc finger protein 236 isoform 1","PF00096,Zinc finger, C2H2 type;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["RP1-283K11.2",49.4396517,8.269109024,2.564209111,3.332266921,{"v":4.53e-07,"d":"4.53E-07"},{"v":2.3E-6,"d":"2.30E-06"},"-","-","-","-","-","-","-","-"]
["AGAP4",1.162009922,0.188637562,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000188234","A0A087X0Z1,Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4","-","PF12796,Ankyrin repeats (3 copies);PF01412,Putative GTPase activating protein for Arf","IPR037278,ARFGAP/RecO-like zinc finger;IPR038508,ArfGAP domain superfamily;IPR001849,Pleckstrin homology domain;IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR001164,Arf GTPase activating protein;IPR002110,Ankyrin repeat","COG5347,GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport;KOG0705,GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains)","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0046872,molecular_function,metal ion binding;GO:0005096,molecular_function,GTPase activator activity","-"]
["RP11-867G23.1",8.427604321,1.368114593,2.561329584,1.619007828,0.010319298,0.01957662,"-","-","-","-","-","-","-","-"]
["PCED1B",1.541948995,0.250315848,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000179715","A0A024R115,Family with sequence similarity 113, member B, isoform CRA_a","NP_612380.1,PC-esterase domain-containing protein 1B;XP_016875700.1,-;XP_016875701.1,-;XP_016875704.1,-;XP_016875699.1,-;XP_016875698.1,-;XP_016875702.1,-;XP_011537280.1,-;XP_016875696.1,-;XP_016875697.1,-;XP_016875703.1,-;XP_016875705.1,-;NP_001268358.1,-;XP_005269281.1,-","-","-","ENOG410IGGE,-;ENOG410ZZG9,-","-","-"]
["TBC1D28",1.07734787,0.174893752,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000189375","G3SE53,TBC1 domain family member 26","-","PF00566,Rab-GTPase-TBC domain","-","-","-","-"]
["CTB-131K11.1",4.693979616,0.762008012,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000266469","G3H5X1,Uncharacterized protein","-","-","-","-","-","-"]
["APCDD1",0.679256683,0.110268701,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000154856","K7AHR8,Adenomatosis polyposis coli down-regulated 1","XP_016788781.1,protein APCDD1","PF14921,Adenomatosis polyposis coli down-regulated 1","IPR029405,APCDD1 domain","ENOG410IGKQ,-;ENOG410XSNW,-","GO:0001942,biological_process,hair follicle development;GO:0043615,biological_process,astrocyte cell migration;GO:0030178,biological_process,negative regulation of Wnt signaling pathway;GO:0017147,molecular_function,Wnt-protein binding;GO:0016020,cellular_component,membrane;GO:0042802,molecular_function,identical protein binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ZNF615",0.824177719,0.133794792,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000197619","A8K6R9,cDNA FLJ76718","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["PFN4",3.822748551,0.620574707,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000176732","H2QHI9,Profilin","XP_016803625.1,-;XP_016803628.1,-;XP_016803626.1,-;XP_016803627.1,-","PF00235,Profilin","IPR005455,Profilin;IPR036140,Profilin superfamily","KOG1755,Profilin;ENOG41126PD,-","GO:0015629,cellular_component,actin cytoskeleton;GO:0003785,molecular_function,actin monomer binding;GO:0005938,cellular_component,cell cortex;GO:0042989,biological_process,sequestering of actin monomers;GO:0003779,molecular_function,actin binding","K05759,ko05131,Shigellosis;K05759,ko04013,MAPK signaling pathway - fly;K05759,ko04015,Rap1 signaling pathway;K05759,ko04810,Regulation of actin cytoskeleton;K05759,ko05132,Salmonella infection"]
["CCNT2-AS1",4.436068648,0.72013944,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000224043","B4E0A8,cDNA FLJ57500","-","-","-","-","-","-"]
["MN1",0.524739695,0.085184829,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000169184","A0A024R1C3,Meningioma","NP_002421.3,transcriptional activator MN1","-","IPR037644,Transcriptional activator MN1","ENOG410YZ22,-;ENOG410IEWX,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001957,biological_process,intramembranous ossification","-"]
["KRBOX4",0.979811279,0.159059925,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000147121","K7AUB4,Zinc finger family member 673","-","PF01352,KRAB box","IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0005622,cellular_component,intracellular","-"]
["HTR2C",0.833709721,0.135342191,2.561329584,1.619007828,0.010319298,0.01957662,"ENSG00000147246","H2QZ10,5-hydroxytryptamine receptor 2C","NP_001029104.2,5-hydroxytryptamine receptor 2C precursor;XP_009437821.1,-;XP_016802886.1,-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR000377,5-Hydroxytryptamine 2C receptor;IPR017452,GPCR, rhodopsin-like, 7TM;IPR002231,5-hydroxytryptamine receptor family;IPR000276,G protein-coupled receptor, rhodopsin-like","ENOG410XRW9,-;KOG3656,FOG: 7 transmembrane receptor","GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0007626,biological_process,locomotory behavior;GO:0004993,molecular_function,G-protein coupled serotonin receptor activity;GO:0016020,cellular_component,membrane;GO:0004871,molecular_function,signal transducer activity;GO:0007631,biological_process,feeding behavior;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0098664,biological_process,G-protein coupled serotonin receptor signaling pathway;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","K04157,ko04080,Neuroactive ligand-receptor interaction;K04157,ko04540,Gap junction;K04157,ko04726,Serotonergic synapse;K04157,ko04020,Calcium signaling pathway;K04157,ko04750,Inflammatory mediator regulation of TRP channels"]
["PPP1R13B",5.363954118,0.907051946,2.559015177,4.877034934,{"v":5.1e-14,"d":"5.10E-14"},1.23E-12,"ENSG00000088808","H2Q8Z5,Protein phosphatase 1, regulatory","XP_510191.3,apoptosis-stimulating of p53 protein 1 isoform X7","PF12796,Ankyrin repeats (3 copies);PF00018,SH3 domain","IPR002110,Ankyrin repeat;IPR028319,Apoptosis-stimulating of p53 protein 1;IPR036028,SH3-like domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR001452,SH3 domain;IPR029071,Ubiquitin-like domain superfamily","KOG0515,p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains;ENOG410Y17W,-","GO:0006915,biological_process,apoptotic process;GO:0045786,biological_process,negative regulation of cell cycle;GO:0008134,molecular_function,transcription factor binding;GO:0072332,biological_process,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005886,cellular_component,plasma membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["PTPN4",2.947807346,0.498606876,2.557061643,4.495416165,{"v":2.78e-12,"d":"2.78E-12"},{"v":4.52e-11,"d":"4.52E-11"},"ENSG00000088179","A0A024RAE8,Tyrosine-protein phosphatase non-receptor type","NP_002821.1,tyrosine-protein phosphatase non-receptor type 4;XP_016860089.1,-","PF00595,PDZ domain (Also known as DHR or GLGF);PF09380,RM C-terminal PH-like domain;PF09379,RM N-terminal domain;PF08736,RM adjacent (FA);PF00102,Protein-tyrosine phosphatase;PF00373,RM central domain","IPR019747,FERM conserved site;IPR014847,FERM adjacent (FA);IPR029021,Protein-tyrosine phosphatase-like;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR018979,FERM, N-terminal;IPR019748,FERM central domain;IPR000387,Tyrosine specific protein phosphatases domain;IPR000299,FERM domain;IPR019749,Band 4.1 domain;IPR000242,PTP type protein phosphatase;IPR011993,PH-like domain superfamily;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR012151,Protein-tyrosine phosphatase, non-receptor type-3, -4;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR035963,FERM superfamily, second domain;IPR016130,Protein-tyrosine phosphatase, active site;IPR029071,Ubiquitin-like domain superfamily;IPR018980,FERM, C-terminal PH-like domain","ENOG410KDUQ,-;COG5599,Protein tyrosine phosphatase","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0006470,biological_process,protein dephosphorylation;GO:0004726,molecular_function,non-membrane spanning protein tyrosine phosphatase activity;GO:0005856,cellular_component,cytoskeleton;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","-"]
["LTBP1",2.916006696,0.491785768,2.556501757,3.750382229,{"v":6.98e-09,"d":"6.98E-09"},{"v":5.33e-08,"d":"5.33E-08"},"ENSG00000049323","G3R903,Latent transforming growth factor beta binding protein 1","XP_004029132.1,latent-transforming growth factor beta-binding protein 1 isoform X1","PF07645,Calcium-binding EGF domain;PF00683,TB domain;PF12662,Complement Clr-like EGF-like","IPR018097,EGF-like calcium-binding, conserved site;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR001881,EGF-like calcium-binding domain;IPR026823,Complement Clr-like EGF domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR017878,TB domain;IPR036773,TGF-beta binding (TB) domain superfamily","-","GO:0005509,molecular_function,calcium ion binding","-"]
["CIZ1",132.8730943,22.63140912,2.553390384,9.089856052,{"v":7.22e-30,"d":"7.22E-30"},1.94E-27,"ENSG00000148337","F5H2X7,Cip1-interacting zinc finger protein","NP_001244904.1,cip1-interacting zinc finger protein isoform 5","PF12171,Zinc-finger double-stranded RNA-binding","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR000690,Matrin/U1-C, C2H2-type zinc finger;IPR022755,Zinc finger, double-stranded RNA binding;IPR026811,Cip1-interacting zinc finger protein;IPR003604,Matrin/U1-C-like, C2H2-type zinc finger","ENOG4111HAM,-;ENOG410II97,-","GO:0030332,molecular_function,cyclin binding;GO:0003676,molecular_function,nucleic acid binding;GO:0051457,biological_process,maintenance of protein location in nucleus;GO:0005886,cellular_component,plasma membrane;GO:0046872,molecular_function,metal ion binding;GO:0032298,biological_process,positive regulation of DNA-dependent DNA replication initiation;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["FAM83D",10.17001026,1.72106052,2.553311897,3.973379265,{"v":1.16e-09,"d":"1.16E-09"},{"v":1.06e-08,"d":"1.06E-08"},"ENSG00000101447","A0A087WXK8,Chromosome 20 open reading frame 129","-","PF07894,Protein of unknown function (DUF1669)","IPR012461,FAM83","ENOG410IGVW,-;ENOG410ZYBU,-","-","-"]
["RP1-118J21.5",7.562425009,1.252216988,2.553052049,2.082844915,1.068612E-3,0.002566359,"ENSG00000236546","L8I0Q2,Protein L-Myc-1","-","PF00010,Helix-loop-helix DNA-binding domain;PF01056,Myc amino-terminal region","IPR012682,Transcription regulator Myc, N-terminal;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR002418,Transcription regulator Myc;IPR036638,Helix-loop-helix DNA-binding domain superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0046983,molecular_function,protein dimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0005634,cellular_component,nucleus","-"]
["LPAR5",1.822131256,0.301715879,2.553052049,2.082844915,1.068612E-3,0.002566359,"ENSG00000184574","Q5KU18,G protein-coupled receptor 92, isoform CRA_a","NP_001136433.1,-;NP_065133.1,lysophosphatidic acid receptor 5","PF00001,7 transmembrane receptor (rhodopsin family)","IPR017452,GPCR, rhodopsin-like, 7TM;IPR000276,G protein-coupled receptor, rhodopsin-like","ENOG410IF9D,-;ENOG410XTCM,-","GO:0016020,cellular_component,membrane;GO:0004871,molecular_function,signal transducer activity;GO:0007165,biological_process,signal transduction;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","K08390,ko04151,PI3K-Akt signaling pathway;K08390,ko04072,Phospholipase D signaling pathway;K08390,ko05200,Pathways in cancer;K08390,ko04015,Rap1 signaling pathway"]
["ASIC1",1.033333966,0.171103627,2.553052049,2.082844915,1.068612E-3,0.002566359,"ENSG00000110881","H2R2B1,Uncharacterized protein","-","PF00858,Amiloride-sensitive sodium channel","-","-","-","-"]
["AMN",1.277766602,0.211577773,2.553052049,2.082844915,1.068612E-3,0.002566359,"ENSG00000166126","H2Q8Y4,Uncharacterized protein","XP_009426778.1,protein amnionless isoform X1","PF14828,Amnionless","IPR026112,Amnionless","ENOG410XS7P,-;ENOG410II2Q,-","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0015889,biological_process,cobalamin transport;GO:0008104,biological_process,protein localization;GO:0043001,biological_process,Golgi to plasma membrane protein transport;GO:0005102,molecular_function,signaling receptor binding;GO:0016324,cellular_component,apical plasma membrane;GO:0007588,biological_process,excretion;GO:0045177,cellular_component,apical part of cell;GO:0016020,cellular_component,membrane;GO:0005615,cellular_component,extracellular space;GO:0016021,cellular_component,integral component of membrane;GO:0030139,cellular_component,endocytic vesicle","-"]
["RP11-876N24.4",2.765022651,0.457843659,2.553052049,2.082844915,1.068612E-3,0.002566359,"ENSG00000262222","H2RGL3,Uncharacterized protein","-","-","-","-","-","-"]
["MMP2",1.203426643,0.199268262,2.553052049,2.082844915,1.068612E-3,0.002566359,"ENSG00000087245","A0A024R6R4,Matrix metallopeptidase 2","NP_004521.1,72 kDa type IV collagenase isoform 1 preproprotein","PF00413,Matrixin;PF01471,Putative peptidoglycan binding domain;PF00040,ibronectin type II domain;PF00045,Hemopexin","IPR001818,Peptidase M10, metallopeptidase;IPR018486,Hemopexin, conserved site;IPR036375,Hemopexin-like domain superfamily;IPR036365,PGBD-like superfamily;IPR021190,Peptidase M10A;IPR000562,Fibronectin type II domain;IPR002477,Peptidoglycan binding-like;IPR036366,PGBD superfamily;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR013806,Kringle-like fold;IPR006026,Peptidase, metallopeptidase;IPR018487,Hemopexin-like repeats;IPR000585,Hemopexin-like domain;IPR036943,Fibronectin type II domain superfamily;IPR033739,Peptidase M10A, catalytic domain;IPR021158,Peptidase M10A, cysteine switch, zinc binding site;IPR028708,72kDa type IV collagenase","KOG1565,Gelatinase A and related matrix metalloproteases;ENOG410XQ5D,-","GO:0060325,biological_process,face morphogenesis;GO:0001666,biological_process,response to hypoxia;GO:0060346,biological_process,bone trabecula formation;GO:0048705,biological_process,skeletal system morphogenesis;GO:0005615,cellular_component,extracellular space;GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0031012,cellular_component,extracellular matrix;GO:0005739,cellular_component,mitochondrion;GO:0001955,biological_process,blood vessel maturation;GO:0008233,molecular_function,peptidase activity;GO:0030017,cellular_component,sarcomere;GO:0008270,molecular_function,zinc ion binding;GO:0008237,molecular_function,metallopeptidase activity;GO:0045089,biological_process,positive regulation of innate immune response;GO:0046872,molecular_function,metal ion binding;GO:0071230,biological_process,cellular response to amino acid stimulus;GO:0007566,biological_process,embryo implantation;GO:0001957,biological_process,intramembranous ossification;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0005886,cellular_component,plasma membrane;GO:0030574,biological_process,collagen catabolic process","K01398,ko01522,Endocrine resistance;K01398,ko04670,Leukocyte transendothelial migration;K01398,ko05219,Bladder cancer;K01398,ko04915,Estrogen signaling pathway;K01398,ko05200,Pathways in cancer;K01398,ko05205,Proteoglycans in cancer;K01398,ko04912,GnRH signaling pathway;K01398,ko04933,AGE-RAGE signaling pathway in diabetic complications"]
["ADAMTSL5",1.637656174,0.271169748,2.553052049,2.082844915,1.068612E-3,0.002566359,"ENSG00000185761","X6R4H8,ADAMTS-like protein 5","XP_016882234.1,-;NP_998769.2,ADAMTS-like protein 5 precursor","PF05986,ADAM-TS Spacer 1;PF00090,Thrombospondin type 1 domain;PF01759,UNC-6/NTR/C345C module","IPR008993,Tissue inhibitor of metalloproteinases-like, OB-fold;IPR010294,ADAM-TS Spacer 1;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR001134,Netrin domain;IPR018933,Netrin module, non-TIMP type;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","ENOG410XPKZ,-;KOG3538,Disintegrin metalloproteinases with thrombospondin repeats","GO:0005578,,;GO:0005576,cellular_component,extracellular region","-"]
["GS1-114I9.3",8.913669117,1.475961464,2.553052049,2.082844915,1.068612E-3,0.002566359,"-","-","-","-","-","-","-","-"]
["F8",0.617806601,0.102298921,2.553052049,2.082844915,1.068612E-3,0.002566359,"ENSG00000185010","H2R1R6,Uncharacterized protein","XP_003317837.1,coagulation factor VIII isoform X1","PF00394,Multicopper oxidase;PF07731,Multicopper oxidase;PF00754,5/8 type C domain;PF07732,Multicopper oxidase","IPR001117,Multicopper oxidase, type 1;IPR000421,Coagulation factor 5/8 C-terminal domain;IPR014707,Coagulation factor 8;IPR008972,Cupredoxin;IPR011707,Multicopper oxidase, type 3;IPR033138,Multicopper oxidases, conserved site;IPR011706,Multicopper oxidase, type 2;IPR024715,Coagulation factor 5/8-like;IPR008979,Galactose-binding-like domain superfamily","ENOG4111F6G,-;ENOG410IJ6Y,-","GO:0005507,molecular_function,copper ion binding;GO:0016491,molecular_function,oxidoreductase activity;GO:0030168,biological_process,platelet activation;GO:0046872,molecular_function,metal ion binding;GO:0055114,biological_process,oxidation-reduction process","-"]
["CPNE3",15.41994717,2.623250709,2.553043796,5.953660386,{"v":1.18e-19,"d":"1.18E-19"},{"v":9.23e-18,"d":"9.23E-18"},"ENSG00000085719","A0A024R994,Copine III, isoform CRA_a","XP_016869434.1,-;XP_005251150.1,-;NP_003900.1,copine-3","PF07002,Copine;PF00168,C2 domain","IPR036465,von Willebrand factor A-like domain superfamily;IPR037768,Copine, C2B domain;IPR010734,Copine;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR002035,von Willebrand factor, type A","ENOG410XPC8,-;KOG1327,Copine","GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005739,cellular_component,mitochondrion;GO:0005730,cellular_component,nucleolus","-"]
["SMCR8",25.78532076,4.393120232,2.552100012,6.978202596,{"v":2.15e-24,"d":"2.15E-24"},{"v":3.56e-22,"d":"3.56E-22"},"ENSG00000176994","H2QCE3,Smith-Magenis syndrome chromosome region, candidate 8","XP_001157693.1,Smith-Magenis syndrome chromosomal region candidate gene 8 protein","PF11704,Vesicle coat protein involved in Golgi to plasma membrane transport","IPR037520,Folliculin, N-terminal;IPR037521,Folliculin/SMCR8, tripartite DENN domain","ENOG410XQXP,-;ENOG410IE98,-","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:1902902,biological_process,negative regulation of autophagosome assembly;GO:0019901,molecular_function,protein kinase binding;GO:0004860,molecular_function,protein kinase inhibitor activity;GO:0000785,cellular_component,chromatin;GO:0005737,cellular_component,cytoplasm;GO:0010506,biological_process,regulation of autophagy;GO:0032008,biological_process,positive regulation of TOR signaling;GO:0010629,biological_process,negative regulation of gene expression;GO:1901098,biological_process,positive regulation of autophagosome maturation;GO:1990316,cellular_component,Atg1/ULK1 kinase complex;GO:0032045,cellular_component,guanyl-nucleotide exchange factor complex;GO:1903432,biological_process,regulation of TORC1 signaling;GO:0017112,molecular_function,Rab guanyl-nucleotide exchange factor activity;GO:0016242,biological_process,negative regulation of macroautophagy;GO:0005654,cellular_component,nucleoplasm","-"]
["CHD7",16.30423563,2.778444005,2.552025013,7.350454206,9.72E-26,{"v":1.91e-23,"d":"1.91E-23"},"ENSG00000171316","G3R983,Chromodomain helicase DNA binding protein 7","XP_018888114.1,chromodomain-helicase-DNA-binding protein 7 isoform X1","PF07533,BRK domain;PF00176,SNF2 family N-terminal domain;PF00385,Chromo (CHRromatin Organisation MOdifier) domain;PF00271,Helicase conserved C-terminal domain","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR023780,Chromo domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR016197,Chromo-like domain superfamily;IPR006576,BRK domain;IPR000953,Chromo/chromo shadow domain;IPR037259,BRK domain superfamily;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR001650,Helicase, C-terminal","-","GO:0050767,biological_process,regulation of neurogenesis;GO:0003007,biological_process,heart morphogenesis;GO:0008015,biological_process,blood circulation;GO:0007512,biological_process,adult heart development;GO:0048752,biological_process,semicircular canal morphogenesis;GO:0060324,biological_process,face development;GO:0060384,biological_process,innervation;GO:0043010,biological_process,camera-type eye development;GO:0007417,biological_process,central nervous system development;GO:0042471,biological_process,ear morphogenesis;GO:0035904,biological_process,aorta development;GO:0042472,biological_process,inner ear morphogenesis;GO:0021553,biological_process,olfactory nerve development;GO:0030540,biological_process,female genitalia development;GO:0060021,biological_process,roof of mouth development;GO:0050890,biological_process,cognition;GO:0010880,biological_process,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0060041,biological_process,retina development in camera-type eye;GO:0007605,biological_process,sensory perception of sound;GO:0060123,biological_process,regulation of growth hormone secretion;GO:0005524,molecular_function,ATP binding;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0040018,biological_process,positive regulation of multicellular organism growth;GO:0001974,biological_process,blood vessel remodeling;GO:0060173,biological_process,limb development;GO:0042048,biological_process,olfactory behavior;GO:0006338,biological_process,chromatin remodeling;GO:0007628,biological_process,adult walking behavior;GO:0016817,molecular_function,hydrolase activity, acting on acid anhydrides;GO:0030217,biological_process,T cell differentiation;GO:0021772,biological_process,olfactory bulb development;GO:0060429,biological_process,epithelium development;GO:0060411,biological_process,cardiac septum morphogenesis;GO:0005634,cellular_component,nucleus;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0048844,biological_process,artery morphogenesis;GO:0035909,biological_process,aorta morphogenesis;GO:0021545,biological_process,cranial nerve development;GO:0007626,biological_process,locomotory behavior;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005654,cellular_component,nucleoplasm;GO:0036302,biological_process,atrioventricular canal development;GO:0003226,biological_process,right ventricular compact myocardium morphogenesis;GO:0005730,cellular_component,nucleolus;GO:0001501,biological_process,skeletal system development;GO:0003222,biological_process,ventricular trabecula myocardium morphogenesis;GO:0043584,biological_process,nose development;GO:0001701,biological_process,in utero embryonic development;GO:0001568,biological_process,blood vessel development;GO:0035116,biological_process,embryonic hindlimb morphogenesis;GO:0048771,biological_process,tissue remodeling;GO:0048806,biological_process,genitalia development","-"]
["PTPRA",85.54728886,14.59051814,2.551059533,7.813323745,{"v":3.65e-27,"d":"3.65E-27"},{"v":7.82e-25,"d":"7.82E-25"},"ENSG00000132670","B7Z2A4,Receptor-type tyrosine-protein phosphatase","-","PF00102,Protein-tyrosine phosphatase","IPR029021,Protein-tyrosine phosphatase-like;IPR016336,Receptor tyrosine-protein phosphatase, alpha/epsilon-type;IPR000242,PTP type protein phosphatase;IPR016130,Protein-tyrosine phosphatase, active site;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR027262,Receptor tyrosine-protein phosphatase alpha;IPR000387,Tyrosine specific protein phosphatases domain","COG5599,Protein tyrosine phosphatase;KOG4228,Protein tyrosine phosphatase","GO:0016787,molecular_function,hydrolase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0006470,biological_process,protein dephosphorylation;GO:0016020,cellular_component,membrane;GO:0016311,biological_process,dephosphorylation;GO:0016021,cellular_component,integral component of membrane;GO:0016791,molecular_function,phosphatase activity","-"]
["BCL2L11",4.351177189,0.738202415,2.550962244,4.166143828,{"v":9.77e-11,"d":"9.77E-11"},{"v":1.12e-09,"d":"1.12E-09"},"ENSG00000153094","G1QPE5,Bcl-2-like protein 11","-","PF06773,Bim protein N-terminus;PF08945,Bcl-x interacting, BH3 domain","IPR017288,Bcl-2-like protein 11;IPR014771,Apoptosis, Bim N-terminal;IPR015040,Bcl-x interacting, BH3 domain","ENOG410Y8GB,-;ENOG410IZKS,-","GO:0006915,biological_process,apoptotic process;GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0007160,biological_process,cell-matrix adhesion;GO:0032464,biological_process,positive regulation of protein homooligomerization;GO:2000271,biological_process,positive regulation of fibroblast apoptotic process;GO:0090200,biological_process,positive regulation of release of cytochrome c from mitochondria;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0001783,biological_process,B cell apoptotic process;GO:0043065,biological_process,positive regulation of apoptotic process","-"]
["RP11-335O4.3",10.08517992,1.686813102,2.548788878,2.430467197,0.000128569,0.000379855,"-","-","-","-","-","-","-","-"]
["JAZF1-AS1",1.915001172,0.320296623,2.548788878,2.430467197,0.000128569,0.000379855,"ENSG00000234336","B7Z1J1,cDNA FLJ59585","-","-","-","-","-","-"]
["ZNF202",2.024930523,0.340748175,2.54618971,2.708726384,{"v":4.94e-05,"d":"4.94E-05"},0.000160102,"ENSG00000166261","A0A024R3M3,Zinc finger protein 202, isoform CRA_a","XP_016873757.1,-;NP_003446.2,zinc finger protein 202 isoform 1;XP_005271716.1,-;XP_006718964.1,-;XP_011541277.1,-;XP_005271718.1,-;XP_011541275.1,-;NP_001288708.1,-;NP_001288709.1,-;XP_005271717.1,-;XP_011541274.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF02023,SCAN domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR003309,SCAN domain;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR038269,SCAN domain superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","-"]
["PLPP6",3.307019686,0.556493623,2.54618971,2.708726384,{"v":4.94e-05,"d":"4.94E-05"},0.000160102,"ENSG00000205808","H2PS88,Phospholipid phosphatase 6","XP_002819865.2,presqualene diphosphate phosphatase","PF01569,PAP2 superfamily","IPR036938,Phosphatidic acid phosphatase type 2/haloperoxidase superfamily;IPR000326,Phosphatidic acid phosphatase type 2/haloperoxidase","KOG4268,Uncharacterized conserved protein containing PAP2 domain;ENOG410ZVFK,-","GO:0046839,biological_process,phospholipid dephosphorylation;GO:0042577,molecular_function,lipid phosphatase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF74",1.861389717,0.314506586,2.544439388,2.940852779,{"v":7.7e-06,"d":"7.70E-06"},{"v":3e-05,"d":"3.00E-05"},"ENSG00000185252","A8K5P3,cDNA FLJ75153, highly similar to Homo sapiens zinc finger protein 74","NP_001243453.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["NIPAL1",2.579794324,0.43812595,2.542231443,3.314590528,{"v":6.52e-07,"d":"6.52E-07"},{"v":3.21e-06,"d":"3.21E-06"},"ENSG00000163293","H2QPF3,Uncharacterized protein","XP_526773.2,-;XP_016807274.1,-","PF05653,Magnesium transporter NIPA","IPR008521,Magnesium transporter NIPA","ENOG410XNR8,-;KOG2922,Uncharacterized conserved protein","GO:0015095,molecular_function,magnesium ion transmembrane transporter activity;GO:1903830,biological_process,magnesium ion transmembrane transport;GO:0015693,biological_process,magnesium ion transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GSK3A",16.6901217,2.858915178,2.541972033,5.372501448,{"v":1.3e-16,"d":"1.30E-16"},{"v":5.57e-15,"d":"5.57E-15"},"ENSG00000105723","A0A024R0L5,Glycogen synthase kinase 3 alpha, isoform CRA_a","NP_063937.2,glycogen synthase kinase-3 alpha","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0658,Glycogen synthase kinase-3","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","K08822,ko04728,Dopaminergic synapse;K08822,ko04932,Non-alcoholic fatty liver disease (NAFLD);K08822,ko04062,Chemokine signaling pathway"]
["RFX7",9.195188852,1.578280667,2.540066832,5.861842898,{"v":3.85e-19,"d":"3.85E-19"},2.69E-17,"ENSG00000181827","H2Q9H5,Regulatory factor X, 7","XP_016783113.1,DNA-binding protein RFX7 isoform X2","PF02257,RFX DNA-binding domain","IPR003150,DNA-binding RFX-type winged-helix domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR036390,Winged helix DNA-binding domain superfamily","ENOG410IT80,-;ENOG410XSVI,-","GO:0003677,molecular_function,DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["LRRC57",2.838752045,0.484589763,2.54000091,3.854179588,{"v":5.99e-09,"d":"5.99E-09"},{"v":4.63e-08,"d":"4.63E-08"},"ENSG00000180979","G3R2C6,Leucine rich repeat containing 57","XP_004056100.1,-","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","-","-","-"]
["RP11-123K3.4",96.80980769,16.63976679,2.539345747,6.914956835,{"v":7.57e-24,"d":"7.57E-24"},1.15E-21,"ENSG00000258830","V9GYY9,Uncharacterized protein","-","-","IPR024771,SUZ domain;IPR036867,R3H domain superfamily","ENOG410IS8W,-;ENOG41106PI,-","GO:0003676,molecular_function,nucleic acid binding","-"]
["ANAPC1",2.868693884,0.491728739,2.538199983,4.550537042,{"v":3.78e-12,"d":"3.78E-12"},{"v":5.98e-11,"d":"5.98E-11"},"ENSG00000153107","K7CIL4,Anaphase promoting complex subunit 1","XP_016804733.1,anaphase-promoting complex subunit 1 isoform X2","PF12859,Anaphase-promoting complex subunit 1","IPR024990,Anaphase-promoting complex subunit 1","KOG1858,Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24);ENOG410XQ83,-","GO:0005634,cellular_component,nucleus;GO:0070979,biological_process,protein K11-linked ubiquitination;GO:0005680,cellular_component,anaphase-promoting complex","-"]
["IFNGR2",19.97553249,3.431610405,2.537235376,5.158943784,{"v":1.89e-15,"d":"1.89E-15"},{"v":6.41e-14,"d":"6.41E-14"},"ENSG00000159128","E7EUY1,Interferon gamma receptor 2","NP_001316057.1,interferon gamma receptor 2 isoform 1 precursor","PF01108,Tissue factor;PF09294,Interferon-alpha/beta receptor, fibronectin type III","IPR003961,Fibronectin type III;IPR015373,Interferon/interleukin receptor domain;IPR013783,Immunoglobulin-like fold;IPR036116,Fibronectin type III superfamily","ENOG410IVC9,-;ENOG410YR1U,-","GO:0051607,biological_process,defense response to virus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CHMP7",18.24672466,3.138538746,2.536687864,5.68218833,{"v":3.88e-18,"d":"3.88E-18"},{"v":2.24e-16,"d":"2.24E-16"},"ENSG00000147457","B3KUH0,cDNA FLJ39883 fis, clone SPLEN2016268, highly similar to Protein CHMP7","NP_689485.1,charged multivesicular body protein 7 isoform 1","PF03357,Snf7","IPR005024,Snf7 family","KOG2911,Uncharacterized conserved protein;ENOG4110IXB,-","GO:0007034,biological_process,vacuolar transport","K15053,ko04144,Endocytosis"]
["SCAF4",40.56258709,6.996372493,2.534475818,7.144458952,{"v":1.01e-24,"d":"1.01E-24"},1.75E-22,"ENSG00000156304","H2QKY4,SR-related CTD-associated factor 4","XP_003319088.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF04818,RNA polymerase II-binding domain.","IPR006903,RNA polymerase II-binding domain;IPR008942,ENTH/VHS;IPR034369,SCAF4, RNA recognition motif;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR006569,CID domain","ENOG410XT48,-;KOG0132,RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005654,cellular_component,nucleoplasm","-"]
["SMG7",31.72035847,5.476159537,2.533271018,7.283939032,{"v":3.17e-25,"d":"3.17E-25"},{"v":5.87e-23,"d":"5.87E-23"},"ENSG00000116698","F7HCS2,SMG7, nonsense mediated mRNA decay factor","-","PF10374,Telomerase activating protein Est1;PF10373,st1 DNA/RNA binding domain","IPR018834,DNA/RNA-binding domain, Est1-type;IPR019458,Telomerase activating protein Est1;IPR011990,Tetratricopeptide-like helical domain superfamily","ENOG410XQ61,-;ENOG410INQX,-","-","-"]
["DCBLD2",18.51405603,3.197000085,2.532691106,6.948818931,{"v":5.73e-24,"d":"5.73E-24"},{"v":8.86e-22,"d":"8.86E-22"},"ENSG00000057019","G3R422,Discoidin, CUB and LCCL domain containing 2","XP_018879547.1,discoidin, CUB and LCCL domain-containing protein 2","PF00431,CUB domain;PF00754,5/8 type C domain;PF03815,LCCL domain","IPR000421,Coagulation factor 5/8 C-terminal domain;IPR035914,Spermadhesin, CUB domain superfamily;IPR004043,LCCL domain;IPR000859,CUB domain;IPR036609,LCCL domain superfamily;IPR008979,Galactose-binding-like domain superfamily","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PKP4",30.63921455,5.2976557,2.531139701,7.428876117,{"v":1.19e-25,"d":"1.19E-25"},2.27E-23,"ENSG00000144283","A0A0D9SF60,Plakophilin-4","-","PF00514,Armadillo/beta-catenin-like repeat","IPR000225,Armadillo;IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR028443,Plakophilin-4;IPR028435,Plakophilin/Delta catenin","-","GO:0030054,cellular_component,cell junction;GO:0007155,biological_process,cell adhesion;GO:0098609,biological_process,cell-cell adhesion;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005886,cellular_component,plasma membrane;GO:0032467,biological_process,positive regulation of cytokinesis","-"]
["LPAR1",9.592042416,1.654467984,2.529516125,4.610743492,1.81E-12,{"v":3.09e-11,"d":"3.09E-11"},"ENSG00000198121","H2R021,Lysophosphatidic acid receptor 1","XP_016816901.1,-;XP_001147476.1,-;XP_016816902.1,-;XP_001147398.1,-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR002277,Lysophosphatidic acid receptor EDG-2;IPR000276,G protein-coupled receptor, rhodopsin-like;IPR004065,Lysophosphatidic acid receptor;IPR017452,GPCR, rhodopsin-like, 7TM","ENOG410XRW9,-;KOG3656,FOG: 7 transmembrane receptor","GO:0070915,molecular_function,lysophosphatidic acid receptor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","K04289,ko04540,Gap junction;K04289,ko04151,PI3K-Akt signaling pathway;K04289,ko04015,Rap1 signaling pathway;K04289,ko05200,Pathways in cancer;K04289,ko04080,Neuroactive ligand-receptor interaction;K04289,ko04072,Phospholipase D signaling pathway"]
["SLC25A43",12.8068393,2.208967045,2.529516125,4.610743492,1.81E-12,{"v":3.09e-11,"d":"3.09E-11"},"ENSG00000077713","A8K7M0,cDNA FLJ77355","-","PF00153,Mitochondrial carrier protein","IPR018108,Mitochondrial substrate/solute carrier;IPR023395,Mitochondrial carrier domain superfamily;IPR002067,Mitochondrial carrier protein","ENOG410ZRF1,-;KOG0752,Mitochondrial solute carrier protein","GO:0055085,biological_process,transmembrane transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PPARG",8.920895226,1.538706242,2.528891354,4.472114394,{"v":4.71e-12,"d":"4.71E-12"},7.26E-11,"ENSG00000132170","H2R8F6,Peroxisome proliferator-activated receptor gamma","-","PF00105,Zinc finger, C4 type (two domains);PF12577,PPAR gamma N-terminal region;PF00104,Ligand-binding domain of nuclear hormone receptor","IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR022590,Peroxisome proliferator-activated receptor gamma, N-terminal;IPR003074,Peroxisome proliferator-activated receptor;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR003077,Peroxisome proliferator-activated receptor gamma;IPR013088,Zinc finger, NHR/GATA-type","KOG3575,FOG: Hormone receptors;ENOG410XRZC,-","GO:0004879,molecular_function,nuclear receptor activity;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:0048511,biological_process,rhythmic process;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway","-"]
["TIPARP",15.28814327,2.661291848,2.519166211,5.536278988,{"v":2.99e-17,"d":"2.99E-17"},{"v":1.45e-15,"d":"1.45E-15"},"ENSG00000163659","G3S4C9,TCDD inducible poly","-","PF00644,Poly(ADP-ribose) polymerase catalytic domain","-","-","-","-"]
["TBCEL",1.894268965,0.326729931,2.517710705,3.119759741,{"v":1.95E-6,"d":"1.95E-06"},{"v":8.68e-06,"d":"8.68E-06"},"ENSG00000154114","A0A0D9S400,Tubulin folding cofactor E like","XP_008019420.1,-;XP_008019422.1,-;XP_008019419.1,-;XP_008019421.1,-","PF14580,Leucine-rich repeat;PF14560,Ubiquitin-like domain","IPR000626,Ubiquitin domain;IPR029071,Ubiquitin-like domain superfamily;IPR032675,Leucine-rich repeat domain superfamily","-","-","-"]
["POLR3F",4.541587478,0.7833484,2.517710705,3.119759741,{"v":1.95E-6,"d":"1.95E-06"},{"v":8.68e-06,"d":"8.68E-06"},"ENSG00000132664","H2P144,DNA-directed RNA polymerase III subunit RPC6","XP_009231625.1,-","PF05158,RNA polymerase Rpc34 subunit","IPR036390,Winged helix DNA-binding domain superfamily;IPR016049,RNA polymerase Rpc34-like;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR007832,RNA polymerase Rpc34","KOG3233,RNA polymerase III, subunit C34;COG5111,DNA-directed RNA polymerase III, subunit C34","GO:0032728,biological_process,positive regulation of interferon-beta production;GO:0045089,biological_process,positive regulation of innate immune response;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0003690,molecular_function,double-stranded DNA binding;GO:0005666,cellular_component,DNA-directed RNA polymerase III complex;GO:0005634,cellular_component,nucleus;GO:0006383,biological_process,transcription by RNA polymerase III","K03025,ko03020,RNA polymerase;K03025,ko05169,Epstein-Barr virus infection;K03025,ko04623,Cytosolic DNA-sensing pathway;K03025,ko00230,Purine metabolism;K03025,ko00240,Pyrimidine metabolism"]
["PHC1",10.48879788,1.829319726,2.515796838,5.270412532,1.01E-15,{"v":3.65e-14,"d":"3.65E-14"},"ENSG00000111752","B2RXH1,Polyhomeotic homolog 1","-","PF00536,SAM domain (Sterile alpha motif);PF16616,Unstructured region on Polyhomeotic-like protein 1 and 2","IPR038603,FCS-type zinc finger superfamily;IPR012313,Zinc finger, FCS-type;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","ENOG4111UWW,-;ENOG410IGCD,-","GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["PHF13",7.676652347,1.335221863,2.515085831,4.136687431,{"v":2.37e-10,"d":"2.37E-10"},{"v":2.5e-09,"d":"2.50E-09"},"ENSG00000116273","H2PXX3,PHD finger protein 13","XP_525170.2,-","PF00628,PHD-finger","IPR001965,Zinc finger, PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger","ENOG4111YY1,-;ENOG410IMXF,-","GO:0007076,biological_process,mitotic chromosome condensation;GO:0046872,molecular_function,metal ion binding;GO:0000278,biological_process,mitotic cell cycle;GO:0007059,biological_process,chromosome segregation;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["TUT1",2.792280003,0.481621918,2.514780692,2.917408297,{"v":1.15E-5,"d":"1.15E-05"},{"v":4.31e-05,"d":"4.31E-05"},"ENSG00000149016","F5H0R1,Speckle targeted PIP5K1A-regulated poly","NP_073741.2,speckle targeted PIP5K1A-regulated poly(A) polymerase","PF03828,Cid1 family poly A polymerase;PF12874,Zinc-finger of C2H2 type;PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034388,Star-PAP, RNA recognition motif;IPR036236,Zinc finger C2H2 superfamily;IPR002058,PAP/25A-associated;IPR034389,Speckle targeted PIP5K1A-regulated poly(A) polymerase;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily","COG5260,DNA polymerase sigma;KOG2277,S-M checkpoint control protein CID1 and related nucleotidyltransferases","GO:0003730,molecular_function,mRNA 3'-UTR binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005730,cellular_component,nucleolus;GO:0003723,molecular_function,RNA binding;GO:0006378,biological_process,mRNA polyadenylation;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0050265,molecular_function,RNA uridylyltransferase activity","-"]
["B4GAT1",5.501007227,0.94883237,2.514780692,2.917408297,{"v":1.15E-5,"d":"1.15E-05"},{"v":4.31e-05,"d":"4.31E-05"},"ENSG00000174684","H2Q465,UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1","-","PF13896,lycosyl-transferase for dystroglycan","-","ENOG410XRNY,-;KOG3765,Predicted glycosyltransferase","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0035269,biological_process,protein O-linked mannosylation;GO:0007411,biological_process,axon guidance;GO:0006486,biological_process,protein glycosylation;GO:0005794,cellular_component,Golgi apparatus;GO:0016740,molecular_function,transferase activity;GO:0015020,molecular_function,glucuronosyltransferase activity","-"]
["FASTKD5",3.965931445,0.684057297,2.514780692,2.917408297,{"v":1.15E-5,"d":"1.15E-05"},{"v":4.31e-05,"d":"4.31E-05"},"ENSG00000215251","H2RC78,FAST kinase domains 5","XP_016792836.1,-;XP_003316826.3,FAST kinase domain-containing protein 5, mitochondrial","PF08373,RAP domain;PF06743,AST kinase-like protein, subdomain 1;PF08368,AST kinase-like protein, subdomain 2","IPR013579,FAST kinase-like protein, subdomain 2;IPR010622,FAST kinase leucine-rich;IPR013584,RAP domain","ENOG4111F08,-;ENOG410IF51,-","GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0016310,biological_process,phosphorylation","-"]
["CASKIN2",4.200308254,0.731517222,2.511949352,3.939568192,{"v":2.96e-09,"d":"2.96E-09"},{"v":2.44E-8,"d":"2.44E-08"},"ENSG00000177303","K7C321,CASK interacting protein 2","-","PF07653,Variant SH3 domain;PF00536,SAM domain (Sterile alpha motif);PF12796,Ankyrin repeats (3 copies);PF16632,C-terminal region of Caskin;PF16907,Proline rich region of Caskin proteins;PF13857,Ankyrin repeats (many copies)","IPR035498,Caskin1/2, SAM repeat 2;IPR035499,Caskin2, SH3 domain;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR002110,Ankyrin repeat;IPR035497,Caskin1/2, SAM repeat 1;IPR036028,SH3-like domain superfamily;IPR032117,Caskin, C-terminal;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR001452,SH3 domain;IPR001660,Sterile alpha motif domain","KOG0507,CASK-interacting adaptor protein (caskin) and related proteins with ankyrin repeats and SAM domain;COG0666,FOG: Ankyrin repeat","-","-"]
["KIAA1549",1.968165685,0.34277177,2.511949352,3.939568192,{"v":2.96e-09,"d":"2.96E-09"},{"v":2.44E-8,"d":"2.44E-08"},"ENSG00000122778","H2QVG5,Uncharacterized protein","XP_016813716.1,UPF0606 protein KIAA1549 homolog isoform X1","PF12877,omain of unknown function (DUF3827)","IPR024606,Protein of unknown function DUF3827","ENOG410XX42,-;ENOG410IFU4,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TAF4B",1.760594219,0.303673258,2.510692859,2.680983173,{"v":7.46e-05,"d":"7.46E-05"},2.32399E-4,"ENSG00000141384","J3KTH2,HCG38478, isoform CRA_a","NP_001280654.1,transcription initiation factor TFIID subunit 4B isoform 1","PF05236,Transcription initiation factor TFIID component TAF4 family;PF07531,NHR1 homology to TAF","IPR037249,TAFH/NHR1 domain superfamily;IPR003894,TAFH/NHR1;IPR007900,Transcription initiation factor TFIID component TAF4;IPR009072,Histone-fold","KOG2341,TATA box binding protein (TBP)-associated factor, RNA polymerase II;ENOG410XQS6,-","GO:2000648,biological_process,positive regulation of stem cell proliferation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0001650,cellular_component,fibrillar center;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006352,biological_process,DNA-templated transcription, initiation;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005669,cellular_component,transcription factor TFIID complex;GO:0005654,cellular_component,nucleoplasm","-"]
["SGTB",1.652471436,0.285023874,2.510692859,2.680983173,{"v":7.46e-05,"d":"7.46E-05"},2.32399E-4,"ENSG00000197860","H2PFP8,Small glutamine rich tetratricopeptide repeat containing beta","XP_002815651.1,-","PF16546,Homodimerisation domain of SGTA;PF00515,Tetratricopeptide repeat;PF13414,TPR repeat","IPR001440,Tetratricopeptide repeat 1;IPR032374,SGTA, homodimerisation domain;IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR011990,Tetratricopeptide-like helical domain superfamily","COG0457,FOG: TPR repeat;KOG0553,TPR repeat-containing protein","-","-"]
["SS18",32.81309625,5.759708996,2.509047622,6.902611044,{"v":2.25e-23,"d":"2.25E-23"},{"v":3.05e-21,"d":"3.05E-21"},"ENSG00000141380","A0A0D9RYZ0,SS18, nBAF chromatin remodeling complex subunit","XP_007972593.1,protein SSXT isoform X1","PF05030,SSXT protein (N-terminal region)","IPR007726,SS18 family","-","GO:0000902,biological_process,cell morphogenesis;GO:0048013,biological_process,ephrin receptor signaling pathway;GO:0071564,cellular_component,npBAF complex;GO:0035556,biological_process,intracellular signal transduction;GO:0007010,biological_process,cytoskeleton organization;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0003713,molecular_function,transcription coactivator activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0097150,biological_process,neuronal stem cell population maintenance;GO:0042493,biological_process,response to drug;GO:0005881,cellular_component,cytoplasmic microtubule;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity","K15623,ko05202,Transcriptional misregulation in cancer"]
["AGAP11",2.468721458,0.425813444,2.504591911,2.396489087,0.000200837,0.000569728,"ENSG00000271880","J3KQL4,Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5","-","PF12796,Ankyrin repeats (3 copies);PF01412,Putative GTPase activating protein for Arf","IPR037278,ARFGAP/RecO-like zinc finger;IPR038508,ArfGAP domain superfamily;IPR001849,Pleckstrin homology domain;IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR001164,Arf GTPase activating protein;IPR002110,Ankyrin repeat","COG5347,GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport;KOG0705,GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains)","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0046872,molecular_function,metal ion binding;GO:0005096,molecular_function,GTPase activator activity","-"]
["ACO1",1.005787511,0.173481639,2.504591911,2.396489087,0.000200837,0.000569728,"ENSG00000122729","V9HWB7,Epididymis luminal protein 60","XP_011516190.1,-;NP_001265281.1,-;XP_005251533.1,-;NP_002188.1,cytoplasmic aconitate hydratase","PF00694,Aconitase C-terminal domain;PF00330,Aconitase family (aconitate hydratase)","IPR015928,Aconitase/3-isopropylmalate dehydratase, swivel;IPR006249,Aconitase/Iron-responsive element-binding protein 2;IPR015931,Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3;IPR001030,Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain;IPR029784,Iron regulatory protein 1;IPR036008,Aconitase, iron-sulfur domain;IPR018136,Aconitase family, 4Fe-4S cluster binding site;IPR000573,Aconitase A/isopropylmalate dehydratase small subunit, swivel domain","KOG0452,RNA-binding translational regulator IRP (aconitase superfamily);COG1048,Aconitase A","GO:0030350,molecular_function,iron-responsive element binding;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0005737,cellular_component,cytoplasm;GO:0006417,biological_process,regulation of translation;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0010040,biological_process,response to iron(II) ion;GO:0010468,biological_process,regulation of gene expression;GO:0051539,molecular_function,4 iron, 4 sulfur cluster binding;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0003994,molecular_function,aconitate hydratase activity;GO:0009791,biological_process,post-embryonic development;GO:0005829,cellular_component,cytosol;GO:0050892,biological_process,intestinal absorption","K01681,ko01210,2-Oxocarboxylic acid metabolism;K01681,ko01230,Biosynthesis of amino acids;K01681,ko00020,Citrate cycle (TCA cycle);K01681,ko01200,Carbon metabolism;K01681,ko00720,Carbon fixation pathways in prokaryotes;K01681,ko00630,Glyoxylate and dicarboxylate metabolism"]
["RP11-227G15.3",205.7141366,36.21235935,2.504074765,6.108224282,{"v":5.76e-20,"d":"5.76E-20"},{"v":4.66e-18,"d":"4.66E-18"},"ENSG00000265794","Q59G94,Zinc finger protein 207 variant","-","-","IPR013087,Zinc finger C2H2-type","KOG2893,Zn finger protein;ENOG410ZJGQ,-","GO:0003676,molecular_function,nucleic acid binding","-"]
["RP11-342M1.3",10.42651225,1.82372975,2.501493553,3.437704191,{"v":2.72E-7,"d":"2.72E-07"},{"v":1.44E-6,"d":"1.44E-06"},"-","-","-","-","-","-","-","-"]
["GBF1",11.47789589,2.022918423,2.501307805,5.521338667,{"v":4.97e-17,"d":"4.97E-17"},{"v":2.35e-15,"d":"2.35E-15"},"ENSG00000107862","H2QZW2,Uncharacterized protein","-","PF12783,uanine nucleotide exchange factor in Golgi transport N-terminal;PF01369,Sec7 domain","-","-","-","-"]
["ZNF268",3.167258412,0.557922858,2.499908046,4.771209644,{"v":4.81e-13,"d":"4.81E-13"},{"v":9.4e-12,"d":"9.40E-12"},"ENSG00000090612","Q2TB61,ZNF268 protein","NP_001159353.1,-;NP_001159354.1,zinc finger protein 268 isoform c","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["NFATC3",9.896419864,1.74882829,2.497866853,5.711007315,{"v":5.69e-18,"d":"5.69E-18"},{"v":3.2e-16,"d":"3.20E-16"},"ENSG00000072736","B5B2S1,Nuclear factor of activated T-cells c3 isoform IB-deltaXa","NP_775188.1,nuclear factor of activated T-cells, cytoplasmic 3 isoform 1","PF00554,Rel homology DNA-binding domain;PF16179,Rel homology dimerisation domain","IPR011539,Rel homology domain (RHD), DNA-binding domain;IPR008967,p53-like transcription factor, DNA-binding;IPR032397,Rel homology dimerisation domain;IPR008366,Nuclear factor of activated T cells (NFAT);IPR037059,Rel homology domain (RHD), DNA-binding domain superfamily;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set;IPR002909,IPT domain","ENOG4111EMW,-;ENOG410IIAD,-","GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K17333,ko04010,MAPK signaling pathway;K17333,ko04921,Oxytocin signaling pathway;K17333,ko04660,T cell receptor signaling pathway;K17333,ko04022,cGMP-PKG signaling pathway;K17333,ko05161,Hepatitis B;K17333,ko04310,Wnt signaling pathway;K17333,ko04662,B cell receptor signaling pathway;K17333,ko04360,Axon guidance;K17333,ko05166,HTLV-I infection"]
["ZNF140",2.783771707,0.487775877,2.497245458,3.278547133,{"v":1.35E-6,"d":"1.35E-06"},{"v":6.24e-06,"d":"6.24E-06"},"ENSG00000196387","H2R0B8,Zinc finger protein 140","XP_001152776.2,zinc finger protein 140 isoform X2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005622,cellular_component,intracellular","-"]
["GREB1L",1.415057619,0.247948123,2.497245458,3.278547133,{"v":1.35E-6,"d":"1.35E-06"},{"v":6.24e-06,"d":"6.24E-06"},"ENSG00000141449","H2QEB4,Growth regulation by estrogen in breast cancer 1 like","XP_016788912.1,GREB1-like protein isoform X2","PF15782,ene regulated by oestrogen in breast cancer","IPR028422,GREB1;IPR024840,GREB1-like","ENOG410IF9T,-;ENOG410Z1PN,-","-","-"]
["PODXL",18.30868155,3.241360818,2.496023901,6.232582712,{"v":1.9e-20,"d":"1.90E-20"},{"v":1.7E-18,"d":"1.70E-18"},"ENSG00000128567","G3QEY9,Podocalyxin","XP_004046291.1,podocalyxin isoform X2","PF06365,CD34/Podocalyxin family","IPR013836,CD34/Podocalyxin;IPR017403,Podocalyxin","-","GO:0030027,cellular_component,lamellipodium;GO:0030175,cellular_component,filopodium;GO:0007155,biological_process,cell adhesion;GO:0001726,cellular_component,ruffle;GO:0070062,cellular_component,extracellular exosome;GO:0007162,biological_process,negative regulation of cell adhesion;GO:0005737,cellular_component,cytoplasm;GO:0042995,cellular_component,cell projection;GO:0005730,cellular_component,nucleolus;GO:0016324,cellular_component,apical plasma membrane;GO:0033634,biological_process,positive regulation of cell-cell adhesion mediated by integrin;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0022407,biological_process,regulation of cell-cell adhesion;GO:0005815,cellular_component,microtubule organizing center;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0030335,biological_process,positive regulation of cell migration;GO:0016021,cellular_component,integral component of membrane;GO:0016477,biological_process,cell migration","-"]
["ZNF782",4.829349558,0.850705612,2.49474562,3.817346107,{"v":1.13E-8,"d":"1.13E-08"},{"v":8.28E-8,"d":"8.28E-08"},"ENSG00000196597","H2QXI8,Zinc finger protein 782","XP_016816744.1,-;XP_016816743.1,zinc finger protein 782 isoform X2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["PARD3B",0.548935031,0.094682174,2.494504845,2.039015624,1.695242E-3,0.003895692,"ENSG00000116117","H2QJA2,Uncharacterized protein","XP_009442358.2,partitioning defective 3 homolog B isoform X1","PF00595,PDZ domain (Also known as DHR or GLGF);PF12053,N-terminal of Par3 and HAL proteins","IPR036034,PDZ superfamily;IPR021922,Par3/HAL, N-terminal;IPR001478,PDZ domain","ENOG410ITA1,-;ENOG410ZRQX,-","GO:0030054,cellular_component,cell junction;GO:0032991,cellular_component,protein-containing complex;GO:0016604,cellular_component,nuclear body;GO:0005654,cellular_component,nucleoplasm","-"]
["TSPAN5",0.767031425,0.13230018,2.494504845,2.039015624,1.695242E-3,0.003895692,"ENSG00000168785","A0A0D9QVU2,Tetraspanin","XP_007997515.1,-","PF00335,Tetraspanin family","IPR018503,Tetraspanin, conserved site;IPR018499,Tetraspanin/Peripherin;IPR008952,Tetraspanin, EC2 domain superfamily;IPR000301,Tetraspanin","-","GO:0019899,molecular_function,enzyme binding;GO:0045747,biological_process,positive regulation of Notch signaling pathway;GO:0072659,biological_process,protein localization to plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0051604,biological_process,protein maturation","-"]
["RP11-61L23.2",1.572149927,0.271169748,2.494504845,2.039015624,1.695242E-3,0.003895692,"ENSG00000253882","B4DLR7,cDNA FLJ58905, moderately similar to Mus musculus experimental autoimmune prostatitis antigen 2","-","-","IPR029062,Class I glutamine amidotransferase-like","ENOG410YE3A,-;ENOG410IKE5,-","-","-"]
["ACTR3B",0.946056356,0.163179007,2.494504845,2.039015624,1.695242E-3,0.003895692,"ENSG00000133627","H2QVN4,ARP3 actin-related protein 3 homolog B","XP_001144350.1,-","PF00022,Actin","IPR004000,Actin family;IPR020902,Actin/actin-like conserved site;IPR015623,Actin-related protein 3","KOG0678,Actin-related protein Arp2/3 complex, subunit Arp3;COG5277,Actin and related proteins","GO:0005885,cellular_component,Arp2/3 protein complex;GO:0007015,biological_process,actin filament organization;GO:0005524,molecular_function,ATP binding;GO:0034314,biological_process,Arp2/3 complex-mediated actin nucleation","-"]
["TTC3P1",0.937188536,0.161649455,2.494504845,2.039015624,1.695242E-3,0.003895692,"ENSG00000215105","G1QK65,Uncharacterized protein","-","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR011990,Tetratricopeptide-like helical domain superfamily","ENOG41103HK,-;ENOG410JR26,-","-","-"]
["DYM",3.567138346,0.632206206,2.487432604,4.020144884,{"v":1.1e-09,"d":"1.10E-09"},{"v":1.01e-08,"d":"1.01E-08"},"ENSG00000141627","H2QEI3,Dymeclin","-","PF09742,yggve-Melchior-Clausen syndrome protein","IPR019142,Dymeclin","KOG2225,Proteins containing regions of low-complexity;ENOG410XP0J,-","GO:0005794,cellular_component,Golgi apparatus;GO:0007030,biological_process,Golgi organization","-"]
["EMSY",4.67544375,0.834244535,2.482419257,5.067466174,{"v":2.02e-14,"d":"2.02E-14"},{"v":5.32e-13,"d":"5.32E-13"},"ENSG00000158636","F6YXL7,EMSY, BRCA2 interacting transcriptional repressor","XP_014970714.1,-","PF03735,NT domain","IPR036142,ENT domain-like superfamily;IPR033482,BRCA2-interacting transcriptional repressor EMSY;IPR005491,ENT domain","ENOG410YF3T,-;KOG4675,Uncharacterized conserved protein, contains ENT domain","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0042803,molecular_function,protein homodimerization activity;GO:0005654,cellular_component,nucleoplasm","-"]
["RP5-991G20.1",8.729431198,1.5564352,2.482242284,4.69757906,{"v":9.18e-13,"d":"9.18E-13"},1.68E-11,"ENSG00000259768","H2QBI0,Zinc finger homeobox 3","-","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type;PF00046,Homeobox domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR017970,Homeobox, conserved site;IPR003604,Matrin/U1-C-like, C2H2-type zinc finger;IPR009057,Homeobox-like domain superfamily;IPR001356,Homeobox domain","KOG1146,Homeobox protein;ENOG410XYHC,-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["ARHGEF7",7.324781844,1.308649041,2.482062615,5.697789346,{"v":1.06e-17,"d":"1.06E-17"},{"v":5.65e-16,"d":"5.65E-16"},"ENSG00000102606","F6Q7V7,Rho guanine nucleotide exchange factor 7","-","PF07653,Variant SH3 domain;PF00621,RhoGEF domain;PF16614,Unstructured region two on RhoGEF 6 and 7;PF16523,betaPIX coiled coil;PF00169,PH domain","IPR001715,Calponin homology domain;IPR001331,Guanine-nucleotide dissociation stimulator, CDC24, conserved site;IPR036872,CH domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR035899,Dbl homology (DH) domain superfamily;IPR035789,Rho guanine nucleotide exchange factor 7, SH3 domain;IPR001452,SH3 domain;IPR000219,Dbl homology (DH) domain","KOG2070,Guanine nucleotide exchange factor;ENOG410XNNP,-","GO:1904424,biological_process,regulation of GTP binding;GO:0000322,cellular_component,storage vacuole;GO:0019901,molecular_function,protein kinase binding;GO:0032991,cellular_component,protein-containing complex;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0043025,cellular_component,neuronal cell body;GO:0030032,biological_process,lamellipodium assembly;GO:0030027,cellular_component,lamellipodium;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005886,cellular_component,plasma membrane;GO:0007030,biological_process,Golgi organization;GO:0043005,cellular_component,neuron projection;GO:0060124,biological_process,positive regulation of growth hormone secretion;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0005829,cellular_component,cytosol;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0032092,biological_process,positive regulation of protein binding;GO:0035556,biological_process,intracellular signal transduction;GO:0043065,biological_process,positive regulation of apoptotic process","-"]
["PDCD6IP",8.118520125,1.450159084,2.481898373,5.470384805,{"v":1.77e-16,"d":"1.77E-16"},{"v":7.34e-15,"d":"7.34E-15"},"ENSG00000170248","G1QY13,Programmed cell death 6 interacting protein","-","PF13949,ALIX V-shaped domain binding to HIV;PF03097,BRO1-like domain","IPR025304,ALIX V-shaped domain;IPR038499,BRO1 domain superfamily;IPR004328,BRO1 domain","ENOG410XQX6,-;KOG2220,Predicted signal transduction protein","GO:0010824,biological_process,regulation of centrosome duplication;GO:0046983,molecular_function,protein dimerization activity;GO:0051260,biological_process,protein homooligomerization;GO:0070971,cellular_component,endoplasmic reticulum exit site;GO:0031871,molecular_function,proteinase activated receptor binding;GO:1903553,biological_process,positive regulation of extracellular exosome assembly;GO:0042803,molecular_function,protein homodimerization activity;GO:0090543,cellular_component,Flemming body;GO:1903551,biological_process,regulation of extracellular exosome assembly;GO:0045199,biological_process,maintenance of epithelial cell apical/basal polarity;GO:0000920,biological_process,cell separation after cytokinesis;GO:0048306,molecular_function,calcium-dependent protein binding;GO:0005829,cellular_component,cytosol;GO:0090611,biological_process,ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:0070830,biological_process,bicellular tight junction assembly;GO:0090559,biological_process,regulation of membrane permeability;GO:0001772,cellular_component,immunological synapse;GO:0042641,cellular_component,actomyosin;GO:0043209,cellular_component,myelin sheath;GO:0070062,cellular_component,extracellular exosome;GO:1903543,biological_process,positive regulation of exosomal secretion;GO:0000281,biological_process,mitotic cytokinesis;GO:0000915,biological_process,actomyosin contractile ring assembly;GO:0046755,biological_process,viral budding;GO:0039702,biological_process,viral budding via host ESCRT complex","-"]
["FGD4",3.797932515,0.678200752,2.47978725,4.633998375,{"v":2.37e-12,"d":"2.37E-12"},{"v":3.91e-11,"d":"3.91E-11"},"ENSG00000139132","F8VWL3,FYVE, RhoGEF and PH domain-containing protein 4","-","PF00621,RhoGEF domain;PF01363,YVE zinc finger;PF00169,PH domain","IPR017455,Zinc finger, FYVE-related;IPR000306,FYVE zinc finger;IPR037742,FGD4, N-terminal PH domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR035899,Dbl homology (DH) domain superfamily;IPR035941,FGD1-4, C-terminal PH domain;IPR000219,Dbl homology (DH) domain","ENOG410XRXV,-;KOG4424,Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3","GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0046872,molecular_function,metal ion binding;GO:0065009,biological_process,regulation of molecular function","-"]
["DTL",6.714190438,1.199744103,2.477595338,4.355524052,{"v":5.24e-11,"d":"5.24E-11"},{"v":6.37e-10,"d":"6.37E-10"},"ENSG00000143476","H2Q136,Denticleless homolog","-","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR019775,WD40 repeat, conserved site;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","KOG0321,WD40 repeat-containing protein L2DTL;ENOG410XRWK,-","-","-"]
["EIF2A",55.70052791,9.994092007,2.477557099,7.0963509,1.14E-23,{"v":1.69e-21,"d":"1.69E-21"},"ENSG00000144895","H2QNK8,Eukaryotic translation initiation factor 2A","XP_001143578.1,eukaryotic translation initiation factor 2A isoform X1","PF08662,ukaryotic translation initiation factor eIF2A","IPR013979,Translation initiation factor, beta propellor-like domain;IPR036322,WD40-repeat-containing domain superfamily;IPR011387,Translation initiation factor 2A;IPR015943,WD40/YVTN repeat-like-containing domain superfamily","KOG2315,Predicted translation initiation factor related to eIF-3a;COG5354,Uncharacterized protein, contains Trp-Asp (WD) repeat","GO:0003743,molecular_function,translation initiation factor activity;GO:0006417,biological_process,regulation of translation;GO:0000049,molecular_function,tRNA binding;GO:0043022,molecular_function,ribosome binding;GO:0006413,biological_process,translational initiation;GO:0022627,cellular_component,cytosolic small ribosomal subunit;GO:0006412,biological_process,translation;GO:0003729,molecular_function,mRNA binding","-"]
["TMEM50B",8.558074202,1.530796963,2.477094767,4.56746283,{"v":6.33e-12,"d":"6.33E-12"},{"v":9.46e-11,"d":"9.46E-11"},"ENSG00000142188","W5PUG2,Transmembrane protein 50B","XP_014947853.1,-;XP_012041615.1,-;XP_004002811.1,-","PF05255,Uncharacterised protein family (UPF0220)","IPR007919,Uncharacterised protein family UPF0220","-","GO:0005783,cellular_component,endoplasmic reticulum;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RGS7",1.475480514,0.25449588,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000182901","K7CHH0,Regulator of G-protein signaling 7","-","PF00631,L domain;PF00610,omain found in Dishevelled, Egl-10, and Pleckstrin (DEP);PF00615,Regulator of G protein signaling domain","IPR036305,RGS domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000591,DEP domain;IPR015898,G-protein gamma-like domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR036284,G-protein gamma-like domain superfamily;IPR016137,RGS domain","ENOG410YMJD,-;KOG3589,G protein signaling regulators","GO:0031681,molecular_function,G-protein beta-subunit binding;GO:0035556,biological_process,intracellular signal transduction;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0005834,cellular_component,heterotrimeric G-protein complex;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0005829,cellular_component,cytosol","-"]
["ACTA2",1.276667448,0.220203928,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000107796","A0A218UWV9,Actin, aortic smooth muscle","-","-","IPR004001,Actin, conserved site;IPR004000,Actin family;IPR020902,Actin/actin-like conserved site","-","GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["RP11-225H22.7",5.782895471,0.99745341,2.474628872,1.557317654,0.016575972,0.029828714,"-","-","-","-","-","-","-","-"]
["ZIC5",0.819004597,0.141264689,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000139800","A0A096NG41,Zic family member 5","-","PF00096,Zinc finger, C2H2 type","-","-","-","-"]
["RP11-20I23.8",1.0478109,0.180729975,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000269937","K7EME6,GLI-Kruppel family member HKR1, isoform CRA_d","-","PF01352,KRAB box","IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0005622,cellular_component,intracellular","-"]
["CDRT1",0.886458778,0.152899414,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000283295","A0A087WSX6,CMT1A duplicated region transcript 1 protein","NP_001269469.1,CMT1A duplicated region transcript 1 protein isoform b","PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat;IPR036047,F-box-like domain superfamily","ENOG410IQCZ,-;ENOG410Z8UQ,-","-","-"]
["ABHD15",1.057728932,0.182440671,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000168792","H2QCK4,Abhydrolase domain containing 15","XP_523591.2,protein ABHD15","PF12146,Serine aminopeptidase, S33","IPR022742,Serine aminopeptidase, S33;IPR029058,Alpha/Beta hydrolase fold","ENOG410Z0Y9,-;ENOG410INFX,-","GO:0016788,molecular_function,hydrolase activity, acting on ester bonds;GO:0044255,biological_process,cellular lipid metabolic process;GO:0016787,molecular_function,hydrolase activity","-"]
["RNF165",0.332722859,0.057389166,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000141622","A0A096MUQ9,Ring finger protein 165","XP_009190927.1,-","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR011016,Zinc finger, RING-CH-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","-","GO:0000209,biological_process,protein polyubiquitination;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0007409,biological_process,axonogenesis;GO:0008045,biological_process,motor neuron axon guidance;GO:0030163,biological_process,protein catabolic process;GO:0046872,molecular_function,metal ion binding;GO:0061061,biological_process,muscle structure development;GO:0010259,biological_process,multicellular organism aging;GO:0060384,biological_process,innervation;GO:0060173,biological_process,limb development;GO:0035136,biological_process,forelimb morphogenesis;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0030513,biological_process,positive regulation of BMP signaling pathway","-"]
["CTD-3113P16.5",7.009893588,1.209090203,2.474628872,1.557317654,0.016575972,0.029828714,"-","-","-","-","-","-","-","-"]
["LONRF2",0.27268803,0.047034156,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000170500","G1RW14,LON peptidase N-terminal domain and ring finger 2","XP_003274896.1,LON peptidase N-terminal domain and RING finger protein 2","PF13923,Zinc finger, C3HC4 type (RING finger);PF13445,RING-type zinc-finger;PF02190,ATP-dependent protease La (LON) substrate-binding domain","IPR003111,Lon, substrate-binding domain;IPR015947,PUA-like superfamily;IPR017907,Zinc finger, RING-type, conserved site;IPR019734,Tetratricopeptide repeat;IPR001841,Zinc finger, RING-type;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR027370,RING-type zinc-finger, LisH dimerisation motif;IPR013026,Tetratricopeptide repeat-containing domain","KOG4159,Predicted E3 ubiquitin ligase;COG2802,Uncharacterized protein, similar to the N-terminal domain of Lon protease;KOG1124,FOG: TPR repeat;KOG0508,Ankyrin repeat protein","GO:0046872,molecular_function,metal ion binding","-"]
["GPR160",0.852257139,0.1470002,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000173890","G3QFI6,G protein-coupled receptor 160","-","-","-","-","-","-"]
["RP11-440L14.1",2.412293539,0.416080565,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000249592","Q9H387,PRO2550","-","-","-","-","-","-"]
["CC2D2A",0.499521736,0.086159202,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000048342","H2QP87,Coiled-coil and C2 domain containing 2A","XP_016806858.1,coiled-coil and C2 domain-containing protein 2A isoform X4","PF00168,C2 domain;PF15625,CC2D2A N-terminal C2 domain","IPR028928,CC2D2A, N-terminal, C2 domain;IPR000008,C2 domain","ENOG410XQVY,-;KOG3639,C2 Ca2+-binding motif-containing protein","-","-"]
["CTD-2325A15.5",6.290334974,1.084978295,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000272234","A0A0D9RW51,Uncharacterized protein","-","PF04592,Selenoprotein P, N terminal region","IPR007671,Selenoprotein P, N-terminal;IPR037941,Selenoprotein P","-","GO:0008430,molecular_function,selenium binding","-"]
["EHMT2-AS1",10.18595797,1.756908553,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000237080","Q8BP38,Uncharacterized protein","-","PF12796,Ankyrin repeats (3 copies);PF00856,SET domain;PF05033,Pre-SET motif","IPR007728,Pre-SET domain;IPR038034,Histone-lysine N-methyltransferase EHMT2;IPR001214,SET domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat","COG2940,Proteins containing SET domain;KOG1082,Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing;COG0666,FOG: Ankyrin repeat","GO:0005694,cellular_component,chromosome;GO:0034968,biological_process,histone lysine methylation;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0002039,molecular_function,p53 binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["PLEKHG1",0.514958298,0.088821753,2.474628872,1.557317654,0.016575972,0.029828714,"ENSG00000120278","Q5JYA6,Pleckstrin homology domain containing, family G","NP_001025055.1,pleckstrin homology domain-containing family G member 1 isoform c;XP_005267122.1,-;NP_001316729.1,-;XP_006715584.1,-;XP_011534285.1,-;NP_001316730.1,-","PF00621,RhoGEF domain","IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR001849,Pleckstrin homology domain;IPR035899,Dbl homology (DH) domain superfamily","ENOG410XR81,-;KOG3518,Putative guanine nucleotide exchange factor","GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm;GO:0065009,biological_process,regulation of molecular function","-"]
["SYT1",1.426077251,0.252281679,2.474300545,2.652668948,1.12452E-4,3.36311E-4,"ENSG00000067715","F7IDL8,Synaptotagmin 1","XP_017831728.1,-;XP_003733856.1,-;XP_017831727.1,-;XP_017831726.1,-","PF00168,C2 domain","IPR001565,Synaptotagmin;IPR000008,C2 domain;IPR015428,Synaptotagmin 1/2;IPR035892,C2 domain superfamily","ENOG410IT3Q,-;ENOG410Z15P,-","GO:0014059,biological_process,regulation of dopamine secretion;GO:0005509,molecular_function,calcium ion binding;GO:0030672,cellular_component,synaptic vesicle membrane;GO:0042734,cellular_component,presynaptic membrane;GO:0043005,cellular_component,neuron projection;GO:0005794,cellular_component,Golgi apparatus;GO:0050750,molecular_function,low-density lipoprotein particle receptor binding;GO:0005544,molecular_function,calcium-dependent phospholipid binding;GO:0008021,cellular_component,synaptic vesicle;GO:0005829,cellular_component,cytosol;GO:0030141,cellular_component,secretory granule;GO:0016021,cellular_component,integral component of membrane;GO:0051966,biological_process,regulation of synaptic transmission, glutamatergic;GO:0050806,biological_process,positive regulation of synaptic transmission;GO:0017158,biological_process,regulation of calcium ion-dependent exocytosis;GO:0030424,cellular_component,axon;GO:0048306,molecular_function,calcium-dependent protein binding;GO:0016079,biological_process,synaptic vesicle exocytosis;GO:0016020,cellular_component,membrane;GO:0007269,biological_process,neurotransmitter secretion;GO:0017075,molecular_function,syntaxin-1 binding;GO:1903861,biological_process,positive regulation of dendrite extension;GO:0098746,biological_process,fast, calcium ion-dependent exocytosis of neurotransmitter;GO:0031045,cellular_component,dense core granule","K15290,ko04721,Synaptic vesicle cycle"]
["WDCP",2.407316264,0.425868787,2.474300545,2.652668948,1.12452E-4,3.36311E-4,"ENSG00000163026","H2QHI5,Chromosome 2 open reading frame 44","XP_001143574.1,WD repeat and coiled-coil-containing protein C2orf44 homolog isoform X1","PF15390,WD repeat and coiled-coil-containing protein family","IPR028041,WD repeat and coiled-coil-containing protein family","ENOG410YM0Q,-;ENOG410IJSA,-","GO:0051259,biological_process,protein complex oligomerization;GO:0019900,molecular_function,kinase binding","-"]
["MLLT10",8.923988181,1.604111898,2.472264288,5.234162012,{"v":3.83e-15,"d":"3.83E-15"},{"v":1.21e-13,"d":"1.21E-13"},"ENSG00000078403","K7CQC4,Myeloid/lymphoid or mixed-lineage leukemia translocated to, 10","XP_016818236.1,protein AF-10 isoform X2","PF13832,PHD-zinc-finger like domain;PF13831,PHD-finger","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR034732,Extended PHD (ePHD) domain;IPR019786,Zinc finger, PHD-type, conserved site","-","GO:0005829,cellular_component,cytosol;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["RRAGC",9.880768577,1.775609921,2.471878477,4.962447612,{"v":4.89e-14,"d":"4.89E-14"},1.19E-12,"ENSG00000116954","A0A0D9S7Q1,Ras related GTP binding C","XP_007977503.1,-","PF04670,tr1/RagA G protein conserved region","IPR006762,Gtr1/RagA G protein;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0019003,molecular_function,GDP binding;GO:0005525,molecular_function,GTP binding;GO:0005764,cellular_component,lysosome;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005737,cellular_component,cytoplasm;GO:0032006,biological_process,regulation of TOR signaling;GO:0051020,molecular_function,GTPase binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0003924,molecular_function,GTPase activity;GO:1903432,biological_process,regulation of TORC1 signaling;GO:0043200,biological_process,response to amino acid;GO:0005634,cellular_component,nucleus;GO:0034198,biological_process,cellular response to amino acid starvation","K16186,ko04150,mTOR signaling pathway"]
["RP11-388M20.2",137.686975,24.78126896,2.469477867,4.909789038,{"v":1.11e-13,"d":"1.11E-13"},2.51E-12,"-","-","-","-","-","-","-","-"]
["PLEKHG6",5.574181814,0.999911922,2.469365837,3.9049202,{"v":5.52E-9,"d":"5.52E-09"},{"v":4.29E-8,"d":"4.29E-08"},"ENSG00000008323","D3DUR0,Pleckstrin homology domain containing, family G","-","PF00621,RhoGEF domain","IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR001849,Pleckstrin homology domain;IPR035899,Dbl homology (DH) domain superfamily","KOG3521,Predicted guanine nucleotide exchange factor;ENOG410XRPT,-","GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0065009,biological_process,regulation of molecular function","-"]
["ADGRL1",9.848706391,1.775953632,2.468643446,5.65623619,{"v":2.45e-17,"d":"2.45E-17"},{"v":1.21e-15,"d":"1.21E-15"},"ENSG00000072071","A0A0A0MWS3,Adhesion G protein-coupled receptor L1","XP_003915085.1,adhesion G protein-coupled receptor L1 isoform X6","PF16489,PCR-Autoproteolysis INducing (GAIN) domain;PF00002,7 transmembrane receptor (Secretin family);PF02191,Olfactomedin-like domain;PF01825,PCR proteolysis site, GPS, motif;PF02793,Hormone receptor domain;PF02354,Latrophilin Cytoplasmic C-terminal region;PF02140,alactose binding lectin domain","IPR032471,GAIN domain, N-terminal;IPR036445,GPCR family 2, extracellular hormone receptor domain superfamily;IPR001879,GPCR, family 2, extracellular hormone receptor domain;IPR000832,GPCR, family 2, secretin-like;IPR017981,GPCR, family 2-like;IPR003334,GPCR, family 2, latrophilin, C-terminal;IPR000203,GPS motif;IPR003112,Olfactomedin-like domain;IPR017983,GPCR, family 2, secretin-like, conserved site;IPR003924,GPCR, family 2, latrophilin;IPR000922,D-galactoside/L-rhamnose binding SUEL lectin domain;IPR031234,Latrophilin-1","-","GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0016020,cellular_component,membrane;GO:0004871,molecular_function,signal transducer activity;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0030246,molecular_function,carbohydrate binding;GO:0007165,biological_process,signal transduction;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["TULP3",38.22055781,6.901430626,2.467529657,6.187634497,{"v":7.09e-20,"d":"7.09E-20"},{"v":5.7e-18,"d":"5.70E-18"},"ENSG00000078246","F7IAK6,Tubby like protein 3","-","PF16322,Tubby N-terminal;PF01167,Tub family","IPR005398,Tubby, N-terminal;IPR000007,Tubby, C-terminal;IPR025659,Tubby-like, C-terminal;IPR018066,Tubby, C-terminal, conserved site","ENOG410XQFT,-;KOG2502,Tub family proteins","GO:0042733,biological_process,embryonic digit morphogenesis;GO:0060831,biological_process,smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0005886,cellular_component,plasma membrane;GO:0008589,biological_process,regulation of smoothened signaling pathway;GO:0061548,biological_process,ganglion development;GO:0005634,cellular_component,nucleus;GO:0021904,biological_process,dorsal/ventral neural tube patterning;GO:0097546,cellular_component,ciliary base;GO:0008277,biological_process,regulation of G-protein coupled receptor protein signaling pathway;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0001841,biological_process,neural tube formation;GO:0060173,biological_process,limb development;GO:0007420,biological_process,brain development;GO:0030991,cellular_component,intraciliary transport particle A;GO:1901621,biological_process,negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0031076,biological_process,embryonic camera-type eye development;GO:0001843,biological_process,neural tube closure;GO:0060348,biological_process,bone development;GO:0021915,biological_process,neural tube development;GO:0060434,biological_process,bronchus morphogenesis;GO:0005930,cellular_component,axoneme;GO:0019899,molecular_function,enzyme binding;GO:0021953,biological_process,central nervous system neuron differentiation;GO:0045879,biological_process,negative regulation of smoothened signaling pathway;GO:0021914,biological_process,negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning;GO:0005730,cellular_component,nucleolus;GO:0005929,cellular_component,cilium;GO:0048702,biological_process,embryonic neurocranium morphogenesis;GO:0009952,biological_process,anterior/posterior pattern specification","-"]
["CTD-3126B10.1",6.976522223,1.24790213,2.46538123,3.078239152,{"v":4.23e-06,"d":"4.23E-06"},{"v":1.75e-05,"d":"1.75E-05"},"ENSG00000261093","A0A0D9S0A5,3-phosphoinositide dependent protein kinase 1","-","PF14593,PH domain;PF00069,Protein kinase domain","IPR011993,PH-like domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR033931,PDK1-type, PH domain;IPR000719,Protein kinase domain","-","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:1903078,biological_process,positive regulation of protein localization to plasma membrane;GO:1905564,biological_process,positive regulation of vascular endothelial cell proliferation;GO:0016004,molecular_function,phospholipase activator activity;GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:2000352,biological_process,negative regulation of endothelial cell apoptotic process;GO:0005524,molecular_function,ATP binding;GO:0051281,biological_process,positive regulation of release of sequestered calcium ion into cytosol;GO:0010518,biological_process,positive regulation of phospholipase activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:0030512,biological_process,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0018107,biological_process,peptidyl-threonine phosphorylation;GO:0032148,biological_process,activation of protein kinase B activity;GO:0004676,molecular_function,3-phosphoinositide-dependent protein kinase activity;GO:0042995,cellular_component,cell projection;GO:0006468,biological_process,protein phosphorylation;GO:0032869,biological_process,cellular response to insulin stimulus;GO:0019722,biological_process,calcium-mediated signaling;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0043536,biological_process,positive regulation of blood vessel endothelial cell migration;GO:1903672,biological_process,positive regulation of sprouting angiogenesis;GO:0043274,molecular_function,phospholipase binding;GO:0043122,biological_process,regulation of I-kappaB kinase/NF-kappaB signaling;GO:0097191,biological_process,extrinsic apoptotic signaling pathway;GO:0016477,biological_process,cell migration","-"]
["SOSTDC1",5.185138635,0.927474369,2.46538123,3.078239152,{"v":4.23e-06,"d":"4.23E-06"},{"v":1.75e-05,"d":"1.75E-05"},"ENSG00000171243","H2RCY3,Sclerostin domain containing 1","XP_016812602.1,-;XP_016801009.1,-","PF05463,Sclerostin (SOST)","IPR006207,Cystine knot, C-terminal;IPR008835,Sclerostin/Sclerostin domain-containing protein 1;IPR029034,Cystine-knot cytokine","ENOG410IIVA,-;ENOG410YEMP,-","GO:0005615,cellular_component,extracellular space","-"]
["CTNND2",34.28864986,6.206651298,2.464889789,7.130380579,1.44E-23,2.08E-21,"ENSG00000169862","H2QQN2,Uncharacterized protein","XP_001147603.2,-","PF00514,Armadillo/beta-catenin-like repeat","IPR000225,Armadillo;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR028435,Plakophilin/Delta catenin","ENOG410Y21Q,-;KOG1048,Neural adherens junction protein Plakophilin and related Armadillo repeat proteins","GO:0098609,biological_process,cell-cell adhesion","-"]
["PTGS2",6.895312626,1.243740539,2.464738801,4.48996776,{"v":1.75e-11,"d":"1.75E-11"},{"v":2.4E-10,"d":"2.40E-10"},"ENSG00000073756","G3RPV2,Prostaglandin-endoperoxide synthase 2","XP_004028113.1,prostaglandin G/H synthase 2","PF03098,Animal haem peroxidase;PF00008,-like domain","IPR029576,Prostaglandin G/H synthase 2;IPR019791,Haem peroxidase, animal type;IPR037120,Haem peroxidase domain superfamily, animal type;IPR010255,Haem peroxidase;IPR000742,EGF-like domain","-","GO:0019371,biological_process,cyclooxygenase pathway;GO:0046697,biological_process,decidualization;GO:0042127,biological_process,regulation of cell proliferation;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:0050873,biological_process,brown fat cell differentiation;GO:0005783,cellular_component,endoplasmic reticulum;GO:0043005,cellular_component,neuron projection;GO:0071456,biological_process,cellular response to hypoxia;GO:0004666,molecular_function,prostaglandin-endoperoxide synthase activity;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0008217,biological_process,regulation of blood pressure;GO:0042803,molecular_function,protein homodimerization activity;GO:0031622,biological_process,positive regulation of fever generation;GO:0006954,biological_process,inflammatory response;GO:0004601,molecular_function,peroxidase activity;GO:0071471,biological_process,cellular response to non-ionic osmotic stress;GO:0031394,biological_process,positive regulation of prostaglandin biosynthetic process;GO:0001516,biological_process,prostaglandin biosynthetic process;GO:0098869,biological_process,cellular oxidant detoxification;GO:0006979,biological_process,response to oxidative stress;GO:0020037,molecular_function,heme binding;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0071498,biological_process,cellular response to fluid shear stress;GO:0019899,molecular_function,enzyme binding;GO:0005737,cellular_component,cytoplasm;GO:0007566,biological_process,embryo implantation;GO:0055114,biological_process,oxidation-reduction process;GO:0090336,biological_process,positive regulation of brown fat cell differentiation;GO:1902219,biological_process,negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress","K11987,ko04923,Regulation of lipolysis in adipocytes;K11987,ko04668,TNF signaling pathway;K11987,ko04726,Serotonergic synapse;K11987,ko05222,Small cell lung cancer;K11987,ko04723,Retrograde endocannabinoid signaling;K11987,ko04913,Ovarian steroidogenesis;K11987,ko04921,Oxytocin signaling pathway;K11987,ko05206,MicroRNAs in cancer;K11987,ko05140,Leishmaniasis;K11987,ko05204,Chemical carcinogenesis;K11987,ko04064,NF-kappa B signaling pathway;K11987,ko04370,VEGF signaling pathway;K11987,ko05200,Pathways in cancer;K11987,ko00590,Arachidonic acid metabolism"]
["EXTL2",4.519307688,0.81339705,2.463767012,3.792239707,{"v":2.15e-08,"d":"2.15E-08"},{"v":1.47e-07,"d":"1.47E-07"},"ENSG00000162694","Q8IYF4,Exostoses","-","PF09258,lycosyl transferase family 64 domain","IPR029044,Nucleotide-diphospho-sugar transferases;IPR015338,Exostosin , C-terminal","KOG1022,Acetylglucosaminyltransferase EXT2/exostosin 2;ENOG410XQYV,-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PAXIP1",4.506399107,0.815505826,2.461049401,4.739110899,{"v":1.55e-12,"d":"1.55E-12"},{"v":2.68e-11,"d":"2.68E-11"},"ENSG00000157212","H2RCH2,Uncharacterized protein","XP_519476.2,PAX-interacting protein 1 isoform X2;XP_016801581.1,-","PF16770,Regulator of Ty1 transposition protein 107 BRCT domain;PF12738,twin BRCT domain;PF00533,BRCA1 C Terminus (BRCT) domain","IPR036420,BRCT domain superfamily;IPR001357,BRCT domain","ENOG410XSGS,-;KOG2043,Signaling protein SWIFT and related BRCT domain proteins","-","-"]
["CNOT4",8.006943033,1.451288298,2.459922728,5.094635027,{"v":1.75e-14,"d":"1.75E-14"},{"v":4.71e-13,"d":"4.71E-13"},"ENSG00000080802","H9FUX7,CCR4-NOT transcription complex subunit 4","XP_014990460.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF14570,RING/Ubox like zinc-binding domain","IPR034261,CNOT4, RNA recognition motif;IPR001841,Zinc finger, RING-type;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000504,RNA recognition motif domain;IPR000571,Zinc finger, CCCH-type;IPR035979,RNA-binding domain superfamily;IPR003954,RNA recognition motif domain, eukaryote","KOG2068,MOT2 transcription factor;COG5175,Transcriptional repressor","GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0003723,molecular_function,RNA binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0051865,biological_process,protein autoubiquitination;GO:0030014,cellular_component,CCR4-NOT complex","-"]
["MAP2K4",44.17573231,8.028155812,2.459228134,7.231647744,{"v":7.99e-24,"d":"7.99E-24"},{"v":1.2E-21,"d":"1.20E-21"},"ENSG00000065559","A0A1D5QAU9,Mitogen-activated protein kinase kinase 4","XP_001114292.1,-","-","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0004672,molecular_function,protein kinase activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005524,molecular_function,ATP binding","K04430,ko04664,Fc epsilon RI signaling pathway;K04430,ko04013,MAPK signaling pathway - fly;K04430,ko04620,Toll-like receptor signaling pathway;K04430,ko04668,TNF signaling pathway;K04430,ko04012,ErbB signaling pathway;K04430,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K04430,ko04010,MAPK signaling pathway;K04430,ko05166,HTLV-I infection;K04430,ko05169,Epstein-Barr virus infection;K04430,ko05164,Influenza A;K04430,ko05142,Chagas disease (American trypanosomiasis);K04430,ko04912,GnRH signaling pathway;K04430,ko05161,Hepatitis B"]
["RP11-231C14.4",1.699668553,0.302621515,2.458998063,2.361648353,3.13333E-4,0.000847901,"ENSG00000169203","F8W0I5,Nuclear pore complex-interacting protein family, member B12","-","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","-","GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-830F9.5",2.408002782,0.428738561,2.458998063,2.361648353,3.13333E-4,0.000847901,"ENSG00000259881","A0A096NUH7,CBFA2/RUNX1 translocation partner 3","-","PF08788,NHR2 domain like;PF07531,NHR1 homology to TAF","IPR037249,TAFH/NHR1 domain superfamily;IPR003894,TAFH/NHR1;IPR014896,NHR2-like;IPR013292,Protein CBFA2T3;IPR013289,CBFA2T family","-","GO:0045820,biological_process,negative regulation of glycolytic process;GO:0032436,biological_process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0008285,biological_process,negative regulation of cell proliferation;GO:1903715,biological_process,regulation of aerobic respiration;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003714,molecular_function,transcription corepressor activity;GO:0001666,biological_process,response to hypoxia;GO:0030851,biological_process,granulocyte differentiation;GO:0005654,cellular_component,nucleoplasm","-"]
["C19orf25",1.440278713,0.256437836,2.458998063,2.361648353,3.13333E-4,0.000847901,"ENSG00000119559","K7EK56,UPF0449 protein C19orf25","-","PF15136,Uncharacterised protein family UPF0449","IPR028227,Uncharacterised protein family UPF0449","ENOG410XTXT,-;ENOG410J2WJ,-","-","-"]
["LINC01123",2.23407117,0.397770495,2.458998063,2.361648353,3.13333E-4,0.000847901,"ENSG00000204588","H2P5D4,Uncharacterized protein","-","-","-","-","-","-"]
["GHR",1.113655749,0.198283477,2.458998063,2.361648353,3.13333E-4,0.000847901,"ENSG00000112964","A0A087X0H5,Growth hormone receptor","NP_001229328.1,growth hormone receptor isoform 2 precursor","PF12772,rowth hormone receptor binding;PF00041,ibronectin type III domain;PF09067,rythropoietin receptor, ligand binding","IPR003961,Fibronectin type III;IPR003528,Long hematopoietin receptor, single chain, conserved site;IPR036116,Fibronectin type III superfamily;IPR015152,Growth hormone/erythropoietin receptor, ligand binding;IPR025871,Growth hormone-binding protein;IPR013783,Immunoglobulin-like fold","ENOG410IFQI,-;ENOG410XTHJ,-","GO:0000187,biological_process,activation of MAPK activity;GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0019901,molecular_function,protein kinase binding;GO:0034097,biological_process,response to cytokine;GO:0005886,cellular_component,plasma membrane;GO:0005634,cellular_component,nucleus;GO:0005615,cellular_component,extracellular space;GO:0007259,biological_process,JAK-STAT cascade;GO:0005737,cellular_component,cytoplasm;GO:0009755,biological_process,hormone-mediated signaling pathway;GO:0042169,molecular_function,SH2 domain binding;GO:0004903,molecular_function,growth hormone receptor activity;GO:0051384,biological_process,response to glucocorticoid;GO:0060416,biological_process,response to growth hormone;GO:0005739,cellular_component,mitochondrion;GO:0005829,cellular_component,cytosol;GO:0016021,cellular_component,integral component of membrane;GO:0046427,biological_process,positive regulation of JAK-STAT cascade;GO:0009725,biological_process,response to hormone;GO:0019903,molecular_function,protein phosphatase binding;GO:0016020,cellular_component,membrane;GO:0032094,biological_process,response to food;GO:0043434,biological_process,response to peptide hormone;GO:0060396,biological_process,growth hormone receptor signaling pathway;GO:0032869,biological_process,cellular response to insulin stimulus;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0043278,biological_process,response to morphine;GO:0043025,cellular_component,neuronal cell body;GO:0060351,biological_process,cartilage development involved in endochondral bone morphogenesis;GO:0070555,biological_process,response to interleukin-1;GO:0045597,biological_process,positive regulation of cell differentiation;GO:1901215,biological_process,negative regulation of neuron death;GO:0042976,biological_process,activation of Janus kinase activity;GO:0004896,molecular_function,cytokine receptor activity","-"]
["ETV1",0.765522515,0.13629927,2.458998063,2.361648353,3.13333E-4,0.000847901,"ENSG00000006468","B5MCT2,ETS translocation variant 1","XP_011513469.1,ETS translocation variant 1 isoform X1","PF04621,PEA3 subfamily ETS-domain transcription factor N terminal domain;PF00178,ts-domain","IPR006715,PEA3-type ETS-domain transcription factor, N-terminal;IPR032928,ETS translocation variant 1;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000418,Ets domain;IPR036390,Winged helix DNA-binding domain superfamily","KOG3806,Predicted transcription factor;ENOG410Z0ZF,-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0003677,molecular_function,DNA binding;GO:0048935,biological_process,peripheral nervous system neuron development;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["S1PR3",0.840902959,0.14972056,2.458998063,2.361648353,3.13333E-4,0.000847901,"ENSG00000213694","H2RBL8,Sphingosine-1-phosphate receptor 3","-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR004061,Sphingosine 1-phosphate receptor;IPR017452,GPCR, rhodopsin-like, 7TM;IPR004062,EDG-3 sphingosine 1-phosphate receptor;IPR000276,G protein-coupled receptor, rhodopsin-like","ENOG410XQD3,-;ENOG410IIA7,-","GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0005178,molecular_function,integrin binding;GO:0001816,biological_process,cytokine production;GO:0003376,biological_process,sphingosine-1-phosphate signaling pathway;GO:0007193,biological_process,adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007219,biological_process,Notch signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:1903141,biological_process,negative regulation of establishment of endothelial barrier;GO:0007165,biological_process,signal transduction;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0005886,cellular_component,plasma membrane;GO:0032651,biological_process,regulation of interleukin-1 beta production;GO:0038036,molecular_function,sphingosine-1-phosphate receptor activity;GO:0016021,cellular_component,integral component of membrane;GO:0006954,biological_process,inflammatory response","K04290,ko04080,Neuroactive ligand-receptor interaction;K04290,ko04071,Sphingolipid signaling pathway"]
["FGF14",2.364418919,0.428660659,2.456708289,4.338412509,{"v":6.88e-11,"d":"6.88E-11"},{"v":8.13e-10,"d":"8.13E-10"},"ENSG00000102466","H2Q7R8,Fibroblast growth factor","XP_009425471.1,-","PF00167,ibroblast growth factor","IPR002209,Fibroblast growth factor family;IPR008996,Cytokine IL1/FGF;IPR028284,Fibroblast growth factor 14","ENOG4111IPH,-;KOG3885,Fibroblast growth factor","GO:0008083,molecular_function,growth factor activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0007399,biological_process,nervous system development;GO:0005576,cellular_component,extracellular region","-"]
["C11orf63",5.023195381,0.910176236,2.45488736,3.893177514,{"v":7.54E-9,"d":"7.54E-09"},{"v":5.7e-08,"d":"5.70E-08"},"ENSG00000109944","G3QTF7,Chromosome 11 open reading frame 63","XP_018893240.1,uncharacterized protein C11orf63 homolog isoform X1;XP_018893242.1,-;XP_018893241.1,-","PF15261,omain of unknown function (DUF4591)","IPR027968,Jhy protein","-","-","-"]
["PARGP1",3.398620623,0.611692804,2.453568986,2.869288738,{"v":2.55E-5,"d":"2.55E-05"},{"v":8.85e-05,"d":"8.85E-05"},"ENSG00000239883","K7D0S7,Poly","-","PF05028,Poly (ADP-ribose) glycohydrolase (PARG)","IPR007724,Poly(ADP-ribose) glycohydrolase","ENOG410XT3Y,-;KOG2064,Poly(ADP-ribose) glycohydrolase","GO:0005975,biological_process,carbohydrate metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0004649,molecular_function,poly(ADP-ribose) glycohydrolase activity","-"]
["LRP4",1.270578886,0.228682176,2.453568986,2.869288738,{"v":2.55E-5,"d":"2.55E-05"},{"v":8.85e-05,"d":"8.85E-05"},"ENSG00000134569","H2Q3I3,Low density lipoprotein receptor-related protein 4","-","PF14670,Coagulation Factor Xa inhibitory site;PF00057,Low-density lipoprotein receptor domain class A;PF12662,Complement Clr-like EGF-like;PF00058,Low-density lipoprotein receptor repeat class B","IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR018097,EGF-like calcium-binding, conserved site;IPR000033,LDLR class B repeat;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011042,Six-bladed beta-propeller, TolB-like;IPR001881,EGF-like calcium-binding domain;IPR026823,Complement Clr-like EGF domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR030799,Low-density lipoprotein receptor-related protein 4;IPR036055,LDL receptor-like superfamily","KOG1215,Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains;ENOG410XPR2,-","GO:0071340,biological_process,skeletal muscle acetylcholine-gated channel clustering;GO:0097105,biological_process,presynaptic membrane assembly;GO:0005509,molecular_function,calcium ion binding;GO:0044332,biological_process,Wnt signaling pathway involved in dorsal/ventral axis specification;GO:0005886,cellular_component,plasma membrane;GO:0051124,biological_process,synaptic growth at neuromuscular junction;GO:0097110,molecular_function,scaffold protein binding;GO:0030971,molecular_function,receptor tyrosine kinase binding;GO:0009986,cellular_component,cell surface;GO:0048813,biological_process,dendrite morphogenesis;GO:0016600,cellular_component,flotillin complex;GO:0050808,biological_process,synapse organization;GO:0030509,biological_process,BMP signaling pathway;GO:0043235,cellular_component,receptor complex;GO:0016021,cellular_component,integral component of membrane;GO:0030425,cellular_component,dendrite;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0048513,biological_process,animal organ development;GO:0017147,molecular_function,Wnt-protein binding;GO:0031594,cellular_component,neuromuscular junction;GO:0014069,cellular_component,postsynaptic density;GO:0016020,cellular_component,membrane;GO:1901631,biological_process,positive regulation of presynaptic membrane organization;GO:0060828,biological_process,regulation of canonical Wnt signaling pathway;GO:0042813,molecular_function,Wnt-activated receptor activity;GO:0043025,cellular_component,neuronal cell body;GO:0051290,biological_process,protein heterotetramerization;GO:0050771,biological_process,negative regulation of axonogenesis;GO:0097060,cellular_component,synaptic membrane;GO:0097104,biological_process,postsynaptic membrane assembly","-"]
["TMTC2",1.312407387,0.236210582,2.453568986,2.869288738,{"v":2.55E-5,"d":"2.55E-05"},{"v":8.85e-05,"d":"8.85E-05"},"ENSG00000179104","G1QZS7,Transmembrane and tetratricopeptide repeat containing 2","-","PF00515,Tetratricopeptide repeat;PF13181,Tetratricopeptide repeat;PF13432,Tetratricopeptide repeat;PF08409,omain of unknown function (DUF1736);PF13424,Tetratricopeptide repeat","IPR001440,Tetratricopeptide repeat 1;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR013618,Domain of unknown function DUF1736;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","ENOG410IQRH,-;ENOG410XP5Q,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TFG",23.72699489,4.3303539,2.452097153,6.153369375,{"v":1.68e-19,"d":"1.68E-19"},1.27E-17,"ENSG00000114354","H2QN07,TRK-fused gene","XP_009444281.1,-;XP_001145405.2,-","PF00564,PB1 domain","IPR034857,TFG, PB1 domain;IPR033512,Protein TFG;IPR000270,PB1 domain","ENOG410Z8FQ,-;ENOG410IH8P,-","GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0005737,cellular_component,cytoplasm;GO:0000139,cellular_component,Golgi membrane;GO:0042802,molecular_function,identical protein binding;GO:0048208,biological_process,COPII vesicle coating","K09292,ko05200,Pathways in cancer;K09292,ko05216,Thyroid cancer"]
["FBXL19",7.058147175,1.283474324,2.45196787,4.256146093,{"v":2.14e-10,"d":"2.14E-10"},{"v":2.27e-09,"d":"2.27E-09"},"ENSG00000099364","I2CX89,F-box/LRR-repeat protein 19","NP_001252649.1,F-box/LRR-repeat protein 19","PF16866,PHD-finger;PF02008,CXXC zinc finger domain;PF00646,-box domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR002857,Zinc finger, CXXC-type;IPR032675,Leucine-rich repeat domain superfamily;IPR006553,Leucine-rich repeat, cysteine-containing subtype;IPR019787,Zinc finger, PHD-finger;IPR019786,Zinc finger, PHD-type, conserved site;IPR001810,F-box domain","-","GO:0003677,molecular_function,DNA binding;GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding","-"]
["RSBN1",3.691270773,0.672721547,2.447222959,3.987437183,{"v":2.75e-09,"d":"2.75E-09"},{"v":2.29E-8,"d":"2.29E-08"},"ENSG00000081019","H2PZP6,Round spermatid basic protein 1","XP_003308358.1,round spermatid basic protein 1","-","IPR026306,RSBN1/Dpy-21","ENOG410XSZP,-;KOG4425,Uncharacterized conserved protein","GO:0005634,cellular_component,nucleus","-"]
["SUPT20H",4.582830939,0.839163675,2.444803243,4.940066869,{"v":1.17e-13,"d":"1.17E-13"},2.61E-12,"ENSG00000102710","G3SJR6,SPT20 homolog, SAGA complex component","XP_018895224.1,transcription factor SPT20 homolog isoform X8","PF12090,Spt20 family","IPR021950,Transcription factor Spt20","-","GO:0003712,molecular_function,transcription cofactor activity;GO:0000124,cellular_component,SAGA complex;GO:0070461,cellular_component,SAGA-type complex;GO:1903506,biological_process,regulation of nucleic acid-templated transcription;GO:0001650,cellular_component,fibrillar center","-"]
["REPS1",6.875017745,1.262606485,2.441620213,5.327331177,1.54E-15,{"v":5.37e-14,"d":"5.37E-14"},"ENSG00000135597","H2PKG3,RALBP1 associated Eps domain containing 1","-","PF12763,Cytoskeletal-regulatory complex EF hand","IPR002048,EF-hand domain;IPR026814,RalBP1-associated Eps domain-containing protein 1;IPR000261,EH domain;IPR011992,EF-hand domain pair;IPR018247,EF-Hand 1, calcium-binding site","ENOG410ZSYS,-;KOG1955,Ral-GTPase effector RALBP1","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0005905,cellular_component,clathrin-coated pit;GO:0005886,cellular_component,plasma membrane;GO:0017124,molecular_function,SH3 domain binding;GO:0005509,molecular_function,calcium ion binding","-"]
["MT-TC",7332.481456,1350.370562,2.440491697,8.168379097,{"v":3.99e-26,"d":"3.99E-26"},{"v":8.22e-24,"d":"8.22E-24"},"-","-","-","-","-","-","-","-"]
["RP11-861E21.2",2.974813906,0.543288689,2.439338947,3.387931905,{"v":7.87e-07,"d":"7.87E-07"},{"v":3.8E-6,"d":"3.80E-06"},"ENSG00000267199","G1S9M7,Tigger transposable element derived 1","XP_004092099.1,tigger transposable element-derived protein 1","PF03184,superfamily endonuclease;PF03221,Tc5 transposase DNA-binding domain;PF04218,CENP-B N-terminal DNA-binding domain","IPR006600,HTH CenpB-type DNA-binding domain;IPR009057,Homeobox-like domain superfamily;IPR007889,DNA binding HTH domain, Psq-type;IPR004875,DDE superfamily endonuclease domain","ENOG4110CDI,-;KOG3105,DNA-binding centromere protein B (CENP-B)","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["EPHA4",1.666056089,0.303633057,2.438487053,3.057001489,{"v":6.22e-06,"d":"6.22E-06"},{"v":2.48E-5,"d":"2.48E-05"},"ENSG00000116106","G3RFQ4,EPH receptor A4","XP_018878184.1,ephrin type-A receptor 4","PF00041,ibronectin type III domain;PF14575,phrin type-A receptor 2 transmembrane domain;PF07647,SAM domain (Sterile alpha motif);PF01404,phrin receptor ligand binding domain;PF07714,Protein tyrosine kinase","IPR013783,Immunoglobulin-like fold;IPR016257,Ephrin receptor type-A /type-B;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001090,Ephrin receptor ligand binding domain;IPR036116,Fibronectin type III superfamily;IPR003961,Fibronectin type III;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR008979,Galactose-binding-like domain superfamily;IPR034270,Ephrin type-A receptor 4, ligand binding domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR011641,Tyrosine-protein kinase ephrin type A/B receptor-like;IPR001426,Tyrosine-protein kinase, receptor class V, conserved site;IPR001660,Sterile alpha motif domain;IPR027936,Ephrin receptor, transmembrane domain;IPR000719,Protein kinase domain","-","GO:0016301,molecular_function,kinase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0005003,molecular_function,ephrin receptor activity;GO:0048013,biological_process,ephrin receptor signaling pathway;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016310,biological_process,phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ST7",1.866714284,0.340202331,2.438487053,3.057001489,{"v":6.22e-06,"d":"6.22E-06"},{"v":2.48E-5,"d":"2.48E-05"},"ENSG00000004866","K7D4Y5,Suppression of tumorigenicity 7","XP_009452303.1,-","PF04184,ST7 protein","IPR007311,ST7;IPR011990,Tetratricopeptide-like helical domain superfamily","KOG3807,Predicted membrane protein ST7 (tumor suppressor in humans);ENOG410XQ2Z,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["KLF3",30.46971532,5.619763708,2.437650858,6.842531618,{"v":4e-22,"d":"4.00E-22"},4.66E-20,"ENSG00000109787","G7P5E4,Basic krueppel-like factor","XP_005554722.1,-;XP_005554723.1,-;XP_005554724.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","K15605,ko05202,Transcriptional misregulation in cancer"]
["TRAPPC11",7.927534383,1.458525864,2.437616099,4.830977654,{"v":5.12e-13,"d":"5.12E-13"},{"v":9.9e-12,"d":"9.90E-12"},"ENSG00000168538","H2QQH8,Chromosome 4 open reading frame 41","XP_009446898.1,trafficking protein particle complex subunit 11 isoform X1;XP_009446899.1,-","PF12742,ryzun, putative Golgi trafficking;PF11817,oie gras liver health family 1","IPR021773,Foie gras liver health family 1;IPR025876,Trafficking protein particle complex subunit 11, C-terminal","KOG4386,Uncharacterized conserved protein;ENOG410XSTE,-","GO:0005794,cellular_component,Golgi apparatus;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0051259,biological_process,protein complex oligomerization;GO:0007030,biological_process,Golgi organization;GO:0030008,cellular_component,TRAPP complex;GO:0061635,biological_process,regulation of protein complex stability","-"]
["C1orf226",2.007449504,0.364475467,2.436966418,2.623759418,0.00016937,0.000486989,"ENSG00000239887","G3RD30,Chromosome 1 open reading frame 226","XP_004027838.1,uncharacterized protein C1orf226 homolog isoform X5","PF15429,omain of unknown function (DUF4628)","IPR027851,Protein of unknown function DUF4628","-","-","-"]
["RP11-649A18.12",3.570829252,0.64832498,2.436966418,2.623759418,0.00016937,0.000486989,"ENSG00000263843","B7Z3Q5,cDNA FLJ52607","-","-","-","-","-","-"]
["NIPSNAP3A",3.490710066,0.633778424,2.436966418,2.623759418,0.00016937,0.000486989,"ENSG00000136783","H2QXM5,Nipsnap homolog 3A","XP_001138149.2,-","PF07978,NIPSNAP","IPR012577,NIPSNAP;IPR011008,Dimeric alpha-beta barrel","ENOG410XSWP,-;KOG2883,NIPSNAP1 protein","GO:0005739,cellular_component,mitochondrion","-"]
["CXorf38",1.493212894,0.271109916,2.436966418,2.623759418,0.00016937,0.000486989,"ENSG00000185753","K7BQZ6,Chromosome X open reading frame 38","XP_016798621.1,uncharacterized protein CXorf38 homolog isoform X1;XP_016798622.1,-","PF15112,omain of unknown function (DUF4559)","IPR027897,Protein of unknown function DUF4559","ENOG410IKE6,-;ENOG4111IY3,-","-","-"]
["SATB1",4.374126026,0.806390759,2.435704982,5.162046404,1.08E-14,3.08E-13,"ENSG00000182568","G3RMB1,DNA-binding protein SATB","-","PF02376,CUT domain;PF16534,Ubiquitin-like oligomerisation domain of SATB;PF16557,CUT1-like DNA-binding domain of SATB;PF00046,Homeobox domain","-","-","-","-"]
["ARHGAP32",7.322966866,1.352399547,2.434578175,5.827933358,{"v":6.48e-18,"d":"6.48E-18"},{"v":3.56e-16,"d":"3.56E-16"},"ENSG00000134909","H2Q541,Uncharacterized protein","-","PF14604,Variant SH3 domain;PF00787,PX domain;PF00620,RhoGAP domain","IPR036871,PX domain superfamily;IPR001683,Phox homologous domain;IPR000198,Rho GTPase-activating protein domain;IPR001452,SH3 domain;IPR008936,Rho GTPase activation protein;IPR036028,SH3-like domain superfamily","ENOG410Y1FN,-;KOG1449,Predicted Rho GTPase-activating protein CdGAPr","GO:0005794,cellular_component,Golgi apparatus;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0015629,cellular_component,actin cytoskeleton;GO:0005938,cellular_component,cell cortex;GO:0001650,cellular_component,fibrillar center;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0005096,molecular_function,GTPase activator activity;GO:0007165,biological_process,signal transduction;GO:0005654,cellular_component,nucleoplasm","-"]
["CH17-335B8.4",36.99304934,6.806065625,2.433566785,3.97636263,{"v":3.73e-09,"d":"3.73E-09"},{"v":3.02e-08,"d":"3.02E-08"},"ENSG00000279458","G3RW27,Annexin","XP_004049413.1,annexin A8","PF00191,Annexin","IPR037104,Annexin superfamily;IPR018502,Annexin repeat;IPR001464,Annexin;IPR018252,Annexin repeat, conserved site;IPR009115,Annexin A8","-","GO:0005544,molecular_function,calcium-dependent phospholipid binding;GO:0005509,molecular_function,calcium ion binding","-"]
["ESPN",0.786631621,0.141580057,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000187017","A0A1B0GUN9,Espin","-","PF12796,Ankyrin repeats (3 copies);PF02205,WH2 motif","IPR003124,WH2 domain;IPR020683,Ankyrin repeat-containing domain;IPR030233,Espin;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","-","GO:0051015,molecular_function,actin filament binding;GO:0051017,biological_process,actin filament bundle assembly;GO:0003779,molecular_function,actin binding","-"]
["CTD-3060P21.1",2.145162349,0.386092041,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000262884","G1PIJ8,RAP1 GTPase activating protein 2","-","PF02145,Rap/ran-GAP","IPR035974,Rap/Ran-GAP superfamily;IPR000331,Rap GTPase activating protein domain","ENOG410XTIX,-;KOG3686,Rap1-GTPase-activating protein (Rap1GAP)","GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0005813,cellular_component,centrosome;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005886,cellular_component,plasma membrane;GO:0005096,molecular_function,GTPase activator activity;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol;GO:0008361,biological_process,regulation of cell size","-"]
["ZNF816",1.650025179,0.296975932,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000180257","A0A024R4J0,Uncharacterized protein","NP_001189385.1,-;NP_001026835.1,zinc finger protein 816;NP_001189386.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["MYO3B",0.663135423,0.119352882,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000071909","B7ZM71,MYO3B protein","NP_001077084.2,myosin-IIIb isoform 1;NP_620482.3,myosin-IIIb isoform 2","PF00069,Protein kinase domain;PF00063,Myosin head (motor domain);PF00612,IQ calmodulin-binding motif","IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036083,Class III myosin, motor domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000048,IQ motif, EF-hand binding site;IPR036961,Kinesin motor domain superfamily;IPR000719,Protein kinase domain","KOG0587,Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases;KOG4229,Myosin VII, myosin IXB and related myosins;COG5022,Myosin heavy chain","GO:0016459,cellular_component,myosin complex;GO:0003774,molecular_function,motor activity;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity;GO:0003779,molecular_function,actin binding","K08834,ko04745,Phototransduction - fly"]
["LEF1-AS1",1.13806696,0.204832327,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000232021","G7PIS2,Uncharacterized protein","-","-","-","-","-","-"]
["EFHC1",0.240217424,0.043234973,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000096093","A0A1B0GVB0,EF-hand domain-containing protein 1","-","PF06565,UF1126 PH-like domain","IPR002048,EF-hand domain;IPR011992,EF-hand domain pair;IPR006602,Uncharacterised domain DM10;IPR010554,Domain of unknown function DUF1126","-","GO:0005509,molecular_function,calcium ion binding","-"]
["INMT-FAM188B",1.896383105,0.341316089,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000254959","F8WBC2,INMT-MINDY4 readthrough","-","PF01234,NNMT/PNMT/TEMT family","IPR000940,Methyltransferase, NNMT/PNMT/TEMT;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR025820,Methyltransferase NNMT/PNMT/TEMT, conserved site","-","GO:0032259,biological_process,methylation;GO:0008168,molecular_function,methyltransferase activity","-"]
["DTX2P1-UPK3BP1-PMS2P11",1.080859557,0.194535986,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000265479","G2HI27,Deltex homolog 2","NP_001267409.1,probable E3 ubiquitin-protein ligase DTX2","PF02825,WWE domain;PF00097,Zinc finger, C3HC4 type (RING finger)","IPR037197,WWE domain superfamily;IPR004170,WWE domain;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR018957,Zinc finger, C3HC4 RING-type;IPR018123,WWE domain, subgroup","-","GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding","K06058,ko04330,Notch signaling pathway"]
["DTX2P1",3.344509088,0.601953665,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000186704","H2QUT5,Deltex homolog 2","XP_016812277.1,probable E3 ubiquitin-protein ligase DTX2 isoform X2;XP_009451489.2,-;XP_009451490.2,-","PF02825,WWE domain;PF00097,Zinc finger, C3HC4 type (RING finger)","IPR037197,WWE domain superfamily;IPR004170,WWE domain;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR018957,Zinc finger, C3HC4 RING-type;IPR018123,WWE domain, subgroup","ENOG410IEMS,-;ENOG4111EY2,-","GO:0031965,cellular_component,nuclear membrane;GO:0007219,biological_process,Notch signaling pathway;GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["PKN3",1.618246916,0.291256396,2.433480821,1.993737972,0.002682185,0.005863135,"ENSG00000160447","A0A024R8D6,Protein kinase N3, isoform CRA_a","NP_037487.2,serine/threonine-protein kinase N3 isoform 1","PF00433,Protein kinase C terminal domain;PF00069,Protein kinase domain;PF02185,Hr1 repeat","IPR037313,Serine/threonine-protein kinase N, first HR1 domain;IPR036274,HR1 repeat superfamily;IPR017892,Protein kinase, C-terminal;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR011072,HR1 rho-binding domain;IPR000719,Protein kinase domain","KOG0694,Serine/threonine protein kinase;ENOG410XNPH,-","GO:0016301,molecular_function,kinase activity;GO:0017049,molecular_function,GTP-Rho binding;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0007165,biological_process,signal transduction;GO:0004672,molecular_function,protein kinase activity","K06071,ko04151,PI3K-Akt signaling pathway;K06071,ko05132,Salmonella infection"]
["NKAPP1",1.695091043,0.305087007,2.433480821,1.993737972,0.002682185,0.005863135,"-","-","-","-","-","-","-","-"]
["ARID1B",4.020728775,0.743709304,2.433411866,6.729133572,1.04E-21,1.13E-19,"ENSG00000049618","H2QTY4,Uncharacterized protein","-","PF12031,SWI/SNF-like complex subunit BAF250/Osa;PF01388,ARID/BRIGHT DNA binding domain","IPR001606,ARID DNA-binding domain;IPR021906,SWI/SNF-like complex subunit BAF250/Osa;IPR036431,ARID DNA-binding domain superfamily;IPR033388,SWI/SNF-like complex subunit BAF250, C-terminal;IPR038040,AT-rich interactive domain-containing protein 1B;IPR016024,Armadillo-type fold","ENOG410Y034,-;KOG2510,SWI-SNF chromatin-remodeling complex protein","GO:0070603,cellular_component,SWI/SNF superfamily-type complex;GO:0016514,cellular_component,SWI/SNF complex;GO:0006338,biological_process,chromatin remodeling;GO:0003677,molecular_function,DNA binding;GO:0071565,cellular_component,nBAF complex;GO:0005634,cellular_component,nucleus","-"]
["RP11-407G23.7",72.28875219,13.33851192,2.432814556,4.656890528,3.07E-12,4.97E-11,"-","-","-","-","-","-","-","-"]
["KLF5",88.62820218,16.41263082,2.432326274,7.683785295,{"v":7.51e-25,"d":"7.51E-25"},{"v":1.34e-22,"d":"1.34E-22"},"ENSG00000102554","Q5T6X2,Kruppel-like factor 5","NP_001721.2,Krueppel-like factor 5 isoform 1","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR030401,Krueppel-like factor 5;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0032534,biological_process,regulation of microvillus assembly;GO:0060576,biological_process,intestinal epithelial cell development;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0005634,cellular_component,nucleus;GO:0030033,biological_process,microvillus assembly;GO:0005794,cellular_component,Golgi apparatus;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:1901653,biological_process,cellular response to peptide;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0045600,biological_process,positive regulation of fat cell differentiation;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0005654,cellular_component,nucleoplasm;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001525,biological_process,angiogenesis;GO:1990830,biological_process,cellular response to leukemia inhibitory factor","-"]
["TMEM35B",23.17940681,4.264600153,2.432108585,3.766673587,{"v":4.08e-08,"d":"4.08E-08"},{"v":2.62e-07,"d":"2.62E-07"},"ENSG00000243749","G3S3L5,Transmembrane protein 35B","XP_004025480.1,-","PF13564,oxX-like family","IPR032808,DoxX family","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NECTIN1",19.98106404,3.701690653,2.430958927,6.528543462,7.75E-21,7.34E-19,"ENSG00000110400","K7BW93,Poliovirus receptor-related 1","XP_016777639.1,nectin-1 isoform X1","PF13927,Immunoglobulin domain;PF08205,CD80-like C2-set immunoglobulin domain;PF07686,Immunoglobulin V-set domain","IPR007110,Immunoglobulin-like domain;IPR033314,Nectin-1;IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain","ENOG410IF17,-;ENOG410YK75,-","GO:0007157,biological_process,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0048593,biological_process,camera-type eye morphogenesis;GO:0005912,cellular_component,adherens junction;GO:0098609,biological_process,cell-cell adhesion;GO:0044291,cellular_component,cell-cell contact zone;GO:0006826,biological_process,iron ion transport;GO:0046982,molecular_function,protein heterodimerization activity;GO:0045202,cellular_component,synapse;GO:0050839,molecular_function,cell adhesion molecule binding;GO:0007155,biological_process,cell adhesion;GO:0043296,cellular_component,apical junction complex;GO:0005913,cellular_component,cell-cell adherens junction;GO:0042803,molecular_function,protein homodimerization activity;GO:0002089,biological_process,lens morphogenesis in camera-type eye;GO:0042802,molecular_function,identical protein binding;GO:0002934,biological_process,desmosome organization;GO:0016021,cellular_component,integral component of membrane;GO:0046718,biological_process,viral entry into host cell;GO:0070166,biological_process,enamel mineralization;GO:0016020,cellular_component,membrane;GO:0004872,-,-;GO:1902414,biological_process,protein localization to cell junction;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0051963,biological_process,regulation of synapse assembly;GO:0060041,biological_process,retina development in camera-type eye","K06081,ko05168,Herpes simplex infection;K06081,ko04520,Adherens junction;K06081,ko04514,Cell adhesion molecules (CAMs)"]
["ZFPM2",2.290612334,0.421432084,2.4300707,3.520607463,{"v":2.34E-7,"d":"2.34E-07"},{"v":1.26E-6,"d":"1.26E-06"},"ENSG00000169946","Q32MA5,Zinc finger protein, multitype 2","-","-","IPR013087,Zinc finger C2H2-type;IPR034731,Zinc finger CCHC FOG-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0006351,biological_process,transcription, DNA-templated","-"]
["MANSC1",4.42153554,0.817115823,2.427732685,4.065451871,{"v":1.4e-09,"d":"1.40E-09"},{"v":1.25e-08,"d":"1.25E-08"},"ENSG00000111261","H2RBH6,MANSC domain containing 1","XP_001139056.2,MANSC domain-containing protein 1","PF07502,MANEC domain","IPR011106,Seven cysteines, N-terminal;IPR013980,MANSC domain","ENOG4112D4M,-;ENOG410IT12,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["THAP3",3.498921591,0.643739578,2.427021709,3.222660777,{"v":4.03e-06,"d":"4.03E-06"},{"v":1.68e-05,"d":"1.68E-05"},"ENSG00000041988","H2PXX4,Uncharacterized protein","XP_514343.2,THAP domain-containing protein 3 isoform X2","PF05485,THAP domain","IPR038441,THAP-type zinc finger superfamily;IPR026520,THAP domain-containing protein 3;IPR006612,THAP-type zinc finger","ENOG410Y1BK,-;ENOG410IRYI,-","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["ZNF207",12.78585431,2.378569384,2.425310441,6.921887834,2.63E-22,{"v":3.16e-20,"d":"3.16E-20"},"ENSG00000010244","X6R4W8,BUB3-interacting and GLEBS motif-containing protein ZNF207","-","-","IPR013087,Zinc finger C2H2-type","KOG2893,Zn finger protein;ENOG410ZJGQ,-","GO:0003676,molecular_function,nucleic acid binding;GO:0005730,cellular_component,nucleolus;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["GLTSCR1L",8.501788045,1.580139367,2.423982597,5.15235819,{"v":1.6e-14,"d":"1.60E-14"},4.38E-13,"ENSG00000112624","H2QT08,KIAA0240","XP_009449547.1,-;XP_016811009.1,-;XP_001135166.1,GLTSCR1-like protein isoform X1;XP_016811011.1,-","PF15249,Conserved region of unknown function on GLTSCR protein","IPR015671,GLTSCR protein, conserved region","ENOG410IG5E,-;ENOG410ZQKZ,-","-","-"]
["DDHD2",4.288771106,0.79723466,2.422753927,4.818748666,{"v":8.04e-13,"d":"8.04E-13"},{"v":1.5E-11,"d":"1.50E-11"},"ENSG00000085788","H2QW15,DDHD domain containing 2","XP_016814835.1,-;XP_016814834.1,-;XP_016814833.1,-;XP_519711.3,phospholipase DDHD2 isoform X1","PF02862,HD domain;PF02825,WWE domain;PF00536,SAM domain (Sterile alpha motif)","IPR004177,DDHD domain;IPR004170,WWE domain;IPR001660,Sterile alpha motif domain;IPR013761,Sterile alpha motif/pointed domain superfamily","KOG2308,Phosphatidic acid-preferring phospholipase A1, contains DDHD domain;ENOG410YDSX,-","GO:0005829,cellular_component,cytosol;GO:0034389,biological_process,lipid particle organization;GO:0019433,biological_process,triglyceride catabolic process;GO:0090141,biological_process,positive regulation of mitochondrial fission;GO:0008542,biological_process,visual learning;GO:0004806,molecular_function,triglyceride lipase activity;GO:0046872,molecular_function,metal ion binding;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0030134,cellular_component,COPII-coated ER to Golgi transport vesicle;GO:0005815,cellular_component,microtubule organizing center;GO:0016020,cellular_component,membrane;GO:0007626,biological_process,locomotory behavior;GO:0004620,molecular_function,phospholipase activity","-"]
["PLAGL1",2.233252886,0.413384321,2.422426974,3.641934114,{"v":7.31e-08,"d":"7.31E-08"},{"v":4.42e-07,"d":"4.42E-07"},"ENSG00000118495","G3RL39,PLAG1 like zinc finger 1","XP_018885486.1,-;XP_018885484.1,-;XP_018885485.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR027770,Zinc finger protein PLAGL1","-","GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["POP1",4.013135184,0.742847876,2.422426974,3.641934114,{"v":7.31e-08,"d":"7.31E-08"},{"v":4.42e-07,"d":"4.42E-07"},"ENSG00000104356","Q96F88,Processing of 1, ribonuclease P/MRP subunit","NP_055844.2,ribonucleases P/MRP protein subunit POP1","PF06978,Ribonucleases P/MRP protein subunit POP1;PF08170,POPLD (NUC188) domain","IPR012590,POPLD;IPR009723,Ribonuclease P/MRP, subunit POP1","KOG3322,Ribonucleases P/MRP protein subunit;ENOG410XT8N,-","GO:0001682,biological_process,tRNA 5'-leader removal;GO:0004526,molecular_function,ribonuclease P activity;GO:0090501,biological_process,RNA phosphodiester bond hydrolysis;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0006396,biological_process,RNA processing","-"]
["RP11-434D12.1",8.00427456,1.472644697,2.42196083,2.844583938,{"v":3.79E-5,"d":"3.79E-05"},1.26542E-4,"ENSG00000268279","V9GY05,Uncharacterized protein","-","PF07787,Transmembrane protein 43","IPR012430,Transmembrane protein 43 family","ENOG410IEFK,-;ENOG410Z3TK,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["VPS8",7.628229633,1.422424757,2.420259893,5.584992127,1.79E-16,{"v":7.38e-15,"d":"7.38E-15"},"ENSG00000156931","C9JJN9,Vacuolar protein sorting-associated protein 8 homolog","-","PF12816,olgi CORVET complex core vacuolar protein 8","IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR025941,Vacuolar protein sorting-associated protein 8, central domain;IPR001841,Zinc finger, RING-type;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR011044,Quinoprotein amine dehydrogenase, beta chain-like;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001680,WD40 repeat","KOG2079,Vacuolar assembly/sorting protein VPS8;ENOG410XRX6,-","-","-"]
["RP11-1379J22.2",12.56147259,2.333310392,2.41978011,3.965199764,{"v":5.06e-09,"d":"5.06E-09"},{"v":3.97e-08,"d":"3.97E-08"},"-","-","-","-","-","-","-","-"]
["PAICS",12.13046372,2.266662118,2.417626409,5.786902429,1.89E-17,{"v":9.61e-16,"d":"9.61E-16"},"ENSG00000128050","G1RBY2,Uncharacterized protein","-","PF00731,AIR carboxylase;PF01259,SAICAR synthetase","IPR033626,Class II PurE;IPR000031,PurE domain;IPR035893,PurE domain superfamily;IPR028923,SAICAR synthetase/ADE2, N-terminal;IPR018236,SAICAR synthetase, conserved site","COG0041,Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase;COG0152,Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase;KOG2835,Phosphoribosylamidoimidazole-succinocarboxamide synthase","GO:0004639,molecular_function,phosphoribosylaminoimidazolesuccinocarboxamide synthase activity;GO:0006189,biological_process,'de novo' IMP biosynthetic process;GO:0006164,biological_process,purine nucleotide biosynthetic process","-"]
["ZFP36",60.13294226,11.24814811,2.416684107,6.186919376,4.09E-19,{"v":2.83e-17,"d":"2.83E-17"},"ENSG00000128016","M0R0H3,mRNA decay activator protein ZFP36","-","PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type","KOG1677,CCCH-type Zn-finger protein;COG5063,CCCH-type Zn-finger protein","GO:0046872,molecular_function,metal ion binding","-"]
["GTDC1",1.492300023,0.277641671,2.416014985,3.753712719,{"v":5.62E-8,"d":"5.62E-08"},{"v":3.51e-07,"d":"3.51E-07"},"ENSG00000121964","H2QIS8,Glycosyltransferase-like domain containing 1","XP_009441700.1,glycosyltransferase-like domain-containing protein 1 isoform X2","PF12038,omain of unknown function (DUF3524);PF00534,lycosyl transferases group 1","IPR001296,Glycosyl transferase, family 1;IPR022701,Glycosyltransferase family 1, N-terminal","ENOG410IICG,-;ENOG410ZWWX,-","GO:0016740,molecular_function,transferase activity","-"]
["SIK2",5.720762994,1.070358334,2.414271305,5.101294062,{"v":3.39e-14,"d":"3.39E-14"},{"v":8.58e-13,"d":"8.58E-13"},"ENSG00000170145","G3RWJ5,Salt inducible kinase 2","XP_004052156.1,-","PF00069,Protein kinase domain","IPR015940,Ubiquitin-associated domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR017090,Serine/threonine-protein kinase, SIK1/2;IPR034672,Salt-Inducible kinase, catalytic domain;IPR000719,Protein kinase domain","-","GO:0004672,molecular_function,protein kinase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0046777,biological_process,protein autophosphorylation;GO:0000287,molecular_function,magnesium ion binding;GO:0005622,cellular_component,intracellular;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","K16311,ko04922,Glucagon signaling pathway"]
["RNF38",5.996468315,1.12103818,2.413427414,4.51523232,2.88E-11,3.74E-10,"ENSG00000137075","G3RJP6,Ring finger protein 38","XP_004048069.1,-","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","-","-","-"]
["NFIB",3.701885539,0.693060166,2.412656115,4.862942613,{"v":5.25e-13,"d":"5.25E-13"},{"v":1.01e-11,"d":"1.01E-11"},"ENSG00000147862","Q5VW26,Nuclear factor 1","XP_005251524.1,nuclear factor 1 B-type isoform X1","PF00859,CTF/NF-I family transcription modulation region;PF03165,MH1 domain;PF10524,Nuclear factor I protein pre-N-terminus","IPR020604,CTF transcription factor/nuclear factor 1, DNA-binding domain;IPR000647,CTF transcription factor/nuclear factor 1;IPR003619,MAD homology 1, Dwarfin-type;IPR019548,CTF transcription factor/nuclear factor 1, N-terminal;IPR019739,CTF transcription factor/nuclear factor 1, conserved site","KOG3663,Nuclear factor I;ENOG410Y16G,-","GO:0003677,molecular_function,DNA binding;GO:0006260,biological_process,DNA replication;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0001650,cellular_component,fibrillar center;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","-"]
["SLC30A4",0.882423431,0.162350276,2.411916147,2.325899634,4.88104E-4,1.265312E-3,"ENSG00000104154","G3RHA3,Solute carrier family 30 member 4","XP_004056174.1,zinc transporter 4 isoform X1","PF01545,Cation efflux family","IPR027469,Cation efflux transmembrane domain superfamily;IPR002524,Cation efflux protein;IPR036837,Cation efflux protein, cytoplasmic domain superfamily","-","GO:0098655,biological_process,cation transmembrane transport;GO:0005737,cellular_component,cytoplasm;GO:0008324,molecular_function,cation transmembrane transporter activity;GO:0006812,biological_process,cation transport;GO:0055085,biological_process,transmembrane transport;GO:0005770,cellular_component,late endosome;GO:0061088,biological_process,regulation of sequestering of zinc ion;GO:0016020,cellular_component,membrane;GO:0009636,biological_process,response to toxic substance;GO:0055069,biological_process,zinc ion homeostasis;GO:0016021,cellular_component,integral component of membrane","-"]
["CTD-3185P2.1",3.285887619,0.604545102,2.411916147,2.325899634,4.88104E-4,1.265312E-3,"ENSG00000261351","I3MD33,Mitogen-activated protein kinase kinase 1","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0581,Mitogen-activated protein kinase kinase (MAP2K);ENOG410XQ5A,-","GO:0000187,biological_process,activation of MAPK activity;GO:0070371,biological_process,ERK1 and ERK2 cascade;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0005783,cellular_component,endoplasmic reticulum;GO:0060324,biological_process,face development;GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:0097110,molecular_function,scaffold protein binding;GO:0004708,molecular_function,MAP kinase kinase activity;GO:0090398,biological_process,cellular senescence;GO:0030878,biological_process,thyroid gland development;GO:0005524,molecular_function,ATP binding;GO:0030182,biological_process,neuron differentiation;GO:0004728,molecular_function,signal transducer, downstream of receptor, with protein tyrosine phosphatase activity;GO:1903800,biological_process,positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:0060440,biological_process,trachea formation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0047485,molecular_function,protein N-terminus binding;GO:0071902,biological_process,positive regulation of protein serine/threonine kinase activity;GO:0010629,biological_process,negative regulation of gene expression;GO:0021697,biological_process,cerebellar cortex formation;GO:0048679,biological_process,regulation of axon regeneration;GO:0005829,cellular_component,cytosol;GO:0018107,biological_process,peptidyl-threonine phosphorylation;GO:0048870,biological_process,cell motility;GO:0010628,biological_process,positive regulation of gene expression;GO:0060425,biological_process,lung morphogenesis;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0050772,biological_process,positive regulation of axonogenesis;GO:0008022,molecular_function,protein C-terminus binding;GO:0043539,molecular_function,protein serine/threonine kinase activator activity;GO:0045597,biological_process,positive regulation of cell differentiation;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0007507,biological_process,heart development;GO:0060711,biological_process,labyrinthine layer development;GO:0048538,biological_process,thymus development;GO:0060502,biological_process,epithelial cell proliferation involved in lung morphogenesis;GO:0007050,biological_process,cell cycle arrest;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0060674,biological_process,placenta blood vessel development;GO:0060020,biological_process,Bergmann glial cell differentiation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0030216,biological_process,keratinocyte differentiation","-"]
["AC084219.2",1.891610292,0.348022778,2.411916147,2.325899634,4.88104E-4,1.265312E-3,"ENSG00000267022","K7ENM7,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["AC072062.1",3.379413832,0.621752268,2.411916147,2.325899634,4.88104E-4,1.265312E-3,"ENSG00000229267","M3Z9P2,Uncharacterized protein","-","PF00078,Reverse transcriptase (RNA-dependent DNA polymerase);PF14529,ndonuclease-reverse transcriptase","-","-","-","-"]
["KALRN",0.290886254,0.053517917,2.411916147,2.325899634,4.88104E-4,1.265312E-3,"ENSG00000160145","J3QSW6,Kalirin","NP_001019831.2,kalirin isoform 1","PF00621,RhoGEF domain;PF00435,Spectrin repeat;PF07679,Immunoglobulin I-set domain;PF00041,ibronectin type III domain;PF16609,SH3-RhoGEF linking unstructured region;PF00069,Protein kinase domain;PF00650,CRAL/TRIO domain;PF00169,PH domain","IPR003961,Fibronectin type III;IPR002017,Spectrin repeat;IPR001849,Pleckstrin homology domain;IPR028569,Kalirin;IPR000219,Dbl homology (DH) domain;IPR000719,Protein kinase domain;IPR035899,Dbl homology (DH) domain superfamily;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set;IPR036865,CRAL-TRIO lipid binding domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR011993,PH-like domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR003599,Immunoglobulin subtype;IPR001452,SH3 domain;IPR018159,Spectrin/alpha-actinin;IPR036116,Fibronectin type III superfamily;IPR001251,CRAL-TRIO lipid binding domain;IPR036028,SH3-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR007110,Immunoglobulin-like domain","-","GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0016310,biological_process,phosphorylation;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0004672,molecular_function,protein kinase activity;GO:0005829,cellular_component,cytosol;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0005524,molecular_function,ATP binding;GO:0005654,cellular_component,nucleoplasm","-"]
["NSUN5P1",1.477354699,0.271807088,2.411916147,2.325899634,4.88104E-4,1.265312E-3,"ENSG00000223705","G3R7U5,NOP2/Sun RNA methyltransferase family member 5","XP_004045648.2,probable 28S rRNA (cytosine-C(5))-methyltransferase isoform X2","PF01189,16S rRNA methyltransferase RsmB/F","IPR001678,SAM-dependent methyltransferase RsmB/NOP2-type;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR023267,RNA (C5-cytosine) methyltransferase","-","GO:0003723,molecular_function,RNA binding;GO:0032259,biological_process,methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0016740,molecular_function,transferase activity","-"]
["SHPK",3.217281802,0.597614413,2.411081987,3.035432149,{"v":9.16e-06,"d":"9.16E-06"},{"v":3.51e-05,"d":"3.51E-05"},"ENSG00000197417","A0A0B4J2A0,Uncharacterized protein","NP_037408.2,sedoheptulokinase","PF00370,Y family of carbohydrate kinases, N-terminal domain","IPR018484,Carbohydrate kinase, FGGY, N-terminal","KOG2517,Ribulose kinase and related carbohydrate kinases;COG0554,Glycerol kinase","GO:0005975,biological_process,carbohydrate metabolic process;GO:0016773,molecular_function,phosphotransferase activity, alcohol group as acceptor","K11214,ko00710,Carbon fixation in photosynthetic organisms"]
["RSAD1",2.94138341,0.546365916,2.411081987,3.035432149,{"v":9.16e-06,"d":"9.16E-06"},{"v":3.51e-05,"d":"3.51E-05"},"ENSG00000136444","G3QUI2,Radical S-adenosyl methionine domain-containing protein","XP_004041384.1,radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X1;XP_018882834.1,-","PF04055,Radical SAM superfamily;PF06969,HemN C-terminal domain","IPR004559,Oxygen-independent coproporphyrinogen III oxidase-like;IPR007197,Radical SAM;IPR010723,HemN, C-terminal;IPR034505,Anaerobic coproporphyrinogen-III oxidase;IPR023404,Radical SAM, alpha/beta horseshoe;IPR006638,Elp3/MiaB/NifB","-","GO:0004109,molecular_function,coproporphyrinogen oxidase activity;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0003824,molecular_function,catalytic activity;GO:0046872,molecular_function,metal ion binding;GO:0006779,biological_process,porphyrin-containing compound biosynthetic process;GO:0005737,cellular_component,cytoplasm;GO:0016491,molecular_function,oxidoreductase activity;GO:0051539,molecular_function,4 iron, 4 sulfur cluster binding;GO:0005739,cellular_component,mitochondrion;GO:0055114,biological_process,oxidation-reduction process","-"]
["FAM228B",2.511783473,0.466567151,2.411081987,3.035432149,{"v":9.16e-06,"d":"9.16E-06"},{"v":3.51e-05,"d":"3.51E-05"},"ENSG00000219626","A0A087WZA1,HCG1820835, isoform CRA_a","-","-","-","-","-","-"]
["MAML1",11.75083413,2.206900659,2.41096148,6.242606788,2.14E-19,{"v":1.6e-17,"d":"1.60E-17"},"ENSG00000161021","G1QM55,Mastermind like transcriptional coactivator 1","-","PF09596,MamL-1 domain","IPR019082,Neurogenic mastermind-like, N-terminal","ENOG410IHPP,-;ENOG4111N9A,-","GO:0045445,biological_process,myoblast differentiation;GO:0019901,molecular_function,protein kinase binding;GO:0051149,biological_process,positive regulation of muscle cell differentiation;GO:0002193,cellular_component,MAML1-RBP-Jkappa- ICN1 complex;GO:0060928,biological_process,atrioventricular node cell development;GO:0003713,molecular_function,transcription coactivator activity;GO:0042605,molecular_function,peptide antigen binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0010831,biological_process,positive regulation of myotube differentiation;GO:0007219,biological_process,Notch signaling pathway;GO:0016607,cellular_component,nuclear speck;GO:0007221,biological_process,positive regulation of transcription of Notch receptor target;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K06061,ko04330,Notch signaling pathway"]
["NORAD",200.0553912,37.62084507,2.410594629,9.312058533,2.12E-27,{"v":4.82e-25,"d":"4.82E-25"},"ENSG00000260032","H2RFY9,Uncharacterized protein","XP_016779210.1,-","-","-","ENOG410KCHV,-;ENOG4110NY8,-","-","-"]
["PRRC1",5.97318106,1.12064947,2.410200765,5.053562596,{"v":7.32e-14,"d":"7.32E-14"},1.71E-12,"ENSG00000164244","F7GWU2,Proline rich coiled-coil 1","-","PF01931,Protein of unknown function DUF84","IPR026534,Protein PRRC1;IPR026533,Non-canonical purine NTP phosphatase/PRRC1;IPR029001,Inosine triphosphate pyrophosphatase-like","ENOG410ZN4R,-;ENOG410IHF5,-","-","-"]
["KMT2E",29.37704321,5.537373788,2.406627327,7.342421732,{"v":1.81e-23,"d":"1.81E-23"},2.58E-21,"ENSG00000005483","H2QV70,Lysine methyltransferase 2E","XP_009452200.1,-;XP_003318778.1,histone-lysine N-methyltransferase 2E isoform X1;XP_016813455.1,-;XP_016813454.1,-;XP_009452199.1,-","PF00856,SET domain;PF00628,PHD-finger","IPR037955,Inactive histone-lysine N-methyltransferase 2E;IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001214,SET domain;IPR019787,Zinc finger, PHD-finger;IPR019786,Zinc finger, PHD-type, conserved site","COG2940,Proteins containing SET domain;KOG1844,PHD Zn-finger proteins","GO:0046872,molecular_function,metal ion binding","K09189,ko00310,Lysine degradation"]
["BRE",5.670481064,1.062587823,2.404756401,3.627764965,{"v":1.02E-7,"d":"1.02E-07"},{"v":5.97e-07,"d":"5.97E-07"},"ENSG00000158019","K7CCA4,Brain and reproductive organ-expressed","XP_009440490.1,-;XP_009440489.1,-;XP_001160523.2,-","PF06113,Brain and reproductive organ-expressed protein (BRE)","IPR010358,BRCA1-A complex subunit BRE","-","GO:0005164,molecular_function,tumor necrosis factor receptor binding;GO:0000152,cellular_component,nuclear ubiquitin ligase complex;GO:0072425,biological_process,signal transduction involved in G2 DNA damage checkpoint;GO:0005737,cellular_component,cytoplasm;GO:0045739,biological_process,positive regulation of DNA repair;GO:0070531,cellular_component,BRCA1-A complex;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0005634,cellular_component,nucleus;GO:0006302,biological_process,double-strand break repair;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0010212,biological_process,response to ionizing radiation;GO:0005829,cellular_component,cytosol;GO:0070552,cellular_component,BRISC complex;GO:0031593,molecular_function,polyubiquitin modification-dependent protein binding","-"]
["PER3",8.79590611,1.658748148,2.40374259,5.440224644,1.08E-15,{"v":3.9e-14,"d":"3.90E-14"},"ENSG00000049246","A6H8X0,PER3 protein","-","PF08447,PAS fold;PF12114,Period protein 2/3C-terminal region","IPR000014,PAS domain;IPR035965,PAS domain superfamily;IPR015524,Period circadian protein 3;IPR013655,PAS fold-3;IPR022728,Period circadian-like, C-terminal","ENOG410Y118,-;KOG3753,Circadian clock protein period","GO:0032922,biological_process,circadian regulation of gene expression","-"]
["CD44",112.177901,21.20999331,2.402783658,9.392102713,2.29E-27,{"v":5.13e-25,"d":"5.13E-25"},"ENSG00000026508","G3QEY3,CD44 molecule","XP_018891955.1,CD44 antigen isoform X4","PF00193,xtracellular link domain","IPR016187,C-type lectin fold;IPR001231,CD44 antigen;IPR000538,Link domain;IPR016186,C-type lectin-like/link domain superfamily","-","GO:0044344,biological_process,cellular response to fibroblast growth factor stimulus;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:2000392,biological_process,regulation of lamellipodium morphogenesis;GO:0005886,cellular_component,plasma membrane;GO:0070487,biological_process,monocyte aggregation;GO:0009986,cellular_component,cell surface;GO:0007155,biological_process,cell adhesion;GO:0031258,cellular_component,lamellipodium membrane;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0043518,biological_process,negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044319,biological_process,wound healing, spreading of cells;GO:0005540,molecular_function,hyaluronic acid binding;GO:0005829,cellular_component,cytosol;GO:0034116,biological_process,positive regulation of heterotypic cell-cell adhesion;GO:0016021,cellular_component,integral component of membrane;GO:1902166,biological_process,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0042995,cellular_component,cell projection;GO:0005794,cellular_component,Golgi apparatus;GO:0030214,biological_process,hyaluronan catabolic process;GO:0016324,cellular_component,apical plasma membrane;GO:0016020,cellular_component,membrane;GO:1900625,biological_process,positive regulation of monocyte aggregation;GO:0035692,cellular_component,macrophage migration inhibitory factor receptor complex;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0004896,molecular_function,cytokine receptor activity;GO:0051216,biological_process,cartilage development","-"]
["CNNM4",5.116673062,0.962772121,2.40177138,4.044415975,{"v":2.55e-09,"d":"2.55E-09"},{"v":2.14E-8,"d":"2.14E-08"},"ENSG00000158158","G3R3R2,Cyclin and CBS domain divalent metal cation transport mediator 4","XP_004031495.1,metal transporter CNNM4 isoform X3","PF01595,omain of unknown function DUF21;PF00571,CBS domain","IPR000595,Cyclic nucleotide-binding domain;IPR018490,Cyclic nucleotide-binding-like;IPR002550,Domain of unknown function DUF21;IPR000644,CBS domain","-","GO:0015095,molecular_function,magnesium ion transmembrane transporter activity;GO:1903830,biological_process,magnesium ion transmembrane transport;GO:0032991,cellular_component,protein-containing complex;GO:0015693,biological_process,magnesium ion transport;GO:0055065,biological_process,metal ion homeostasis;GO:0016021,cellular_component,integral component of membrane;GO:0016323,cellular_component,basolateral plasma membrane;GO:0035725,biological_process,sodium ion transmembrane transport;GO:0070166,biological_process,enamel mineralization;GO:0016020,cellular_component,membrane;GO:0010960,biological_process,magnesium ion homeostasis;GO:0015081,molecular_function,sodium ion transmembrane transporter activity","-"]
["RNF130",6.75970621,1.277739218,2.400912089,5.717614563,{"v":7.09e-17,"d":"7.09E-17"},{"v":3.2e-15,"d":"3.20E-15"},"ENSG00000113269","H2QS61,Ring finger protein 130","-","PF02225,PA domain;PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR003137,PA domain;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG0800,FOG: Predicted E3 ubiquitin ligase;ENOG41121N2,-","-","-"]
["SLITRK6",38.49516019,7.284782475,2.400440185,6.643351281,{"v":8.05e-21,"d":"8.05E-21"},{"v":7.58e-19,"d":"7.58E-19"},"ENSG00000184564","G1S398,SLIT and NTRK like family member 6","XP_003257423.1,SLIT and NTRK-like protein 6;XP_003257424.1,-","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR000483,Cysteine-rich flanking region, C-terminal;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","ENOG4111D19,-;ENOG410IGN5,-","GO:0007409,biological_process,axonogenesis;GO:0090102,biological_process,cochlea development;GO:0035264,biological_process,multicellular organism growth;GO:0005886,cellular_component,plasma membrane;GO:0060384,biological_process,innervation;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0007601,biological_process,visual perception;GO:0042472,biological_process,inner ear morphogenesis;GO:0009986,cellular_component,cell surface;GO:0060005,biological_process,vestibular reflex;GO:0021562,biological_process,vestibulocochlear nerve development;GO:0008344,biological_process,adult locomotory behavior;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0007416,biological_process,synapse assembly;GO:0031223,biological_process,auditory behavior;GO:0001964,biological_process,startle response;GO:0016020,cellular_component,membrane;GO:0002093,biological_process,auditory receptor cell morphogenesis;GO:0043010,biological_process,camera-type eye development;GO:0060007,biological_process,linear vestibuloocular reflex;GO:0071944,cellular_component,cell periphery;GO:0002088,biological_process,lens development in camera-type eye;GO:0048812,biological_process,neuron projection morphogenesis","-"]
["RP11-27M24.1",61.92675459,11.68031042,2.400033457,4.366437146,1.15E-10,{"v":1.29e-09,"d":"1.29E-09"},"ENSG00000256013","Q7Z4B3,MSTP160","NP_001415.1,epithelial membrane protein 2 precursor","-","-","-","-","-"]
["GRK3",2.246210124,0.422655202,2.39973983,3.740630299,{"v":7.75e-08,"d":"7.75E-08"},{"v":4.66e-07,"d":"4.66E-07"},"ENSG00000100077","A0A0D9RCS3,G protein-coupled receptor kinase","XP_007973406.1,-","PF00069,Protein kinase domain;PF00615,Regulator of G protein signaling domain;PF00169,PH domain","IPR036305,RGS domain superfamily;IPR000239,GPCR kinase;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR016137,RGS domain;IPR000719,Protein kinase domain","-","GO:0016301,molecular_function,kinase activity;GO:0031623,biological_process,receptor internalization;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004703,molecular_function,G-protein coupled receptor kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0007165,biological_process,signal transduction;GO:0004674,molecular_function,protein serine/threonine kinase activity","K00910,ko04340,Hedgehog signaling pathway;K00910,ko04144,Endocytosis;K00910,ko05032,Morphine addiction;K00910,ko04740,Olfactory transduction;K00910,ko04724,Glutamatergic synapse;K00910,ko04745,Phototransduction - fly;K00910,ko04062,Chemokine signaling pathway"]
["FRMD4A",0.659215589,0.122922961,2.398640433,2.594228705,0.000254748,0.000705258,"ENSG00000151474","G3RFN6,FERM domain containing 4A","-","PF09379,RM N-terminal domain;PF09380,RM C-terminal PH-like domain;PF00373,RM central domain;PF11819,omain of unknown function (DUF3338)","IPR019748,FERM central domain;IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR019747,FERM conserved site;IPR011993,PH-like domain superfamily;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR021774,Domain of unknown function DUF3338;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR029071,Ubiquitin-like domain superfamily","-","GO:0005856,cellular_component,cytoskeleton","-"]
["SYNPO",0.856504716,0.159711174,2.398640433,2.594228705,0.000254748,0.000705258,"ENSG00000171992","B3KXB8,cDNA FLJ45106 fis, clone BRAWH3033293, highly similar to Synaptopodin","-","-","IPR028753,Synaptopodin","ENOG410IHBK,-;ENOG4111RGH,-","GO:0032233,biological_process,positive regulation of actin filament bundle assembly;GO:0003779,molecular_function,actin binding","-"]
["MATN2",1.267276125,0.236307115,2.398640433,2.594228705,0.000254748,0.000705258,"ENSG00000132561","A0A140VKH7,Testis tissue sperm-binding protein Li 94mP","NP_002371.3,matrilin-2 isoform a precursor","PF14670,Coagulation Factor Xa inhibitory site;PF07645,Calcium-binding EGF domain;PF00092,von Willebrand factor type A domain;PF10393,Trimeric coiled-coil oligomerisation domain of matrilin;PF12662,Complement Clr-like EGF-like","IPR036465,von Willebrand factor A-like domain superfamily;IPR030747,Matrilin-2;IPR036337,Matrilin, coiled-coil domain superfamily;IPR000742,EGF-like domain;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR001881,EGF-like calcium-binding domain;IPR026823,Complement Clr-like EGF domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR019466,Matrilin, coiled-coil trimerisation domain;IPR013032,EGF-like, conserved site;IPR002035,von Willebrand factor, type A","-","GO:0031175,biological_process,neuron projection development;GO:0005578,,;GO:0007411,biological_process,axon guidance;GO:0005604,cellular_component,basement membrane;GO:0005615,cellular_component,extracellular space;GO:0005509,molecular_function,calcium ion binding;GO:0008347,biological_process,glial cell migration;GO:0031104,biological_process,dendrite regeneration;GO:0048678,biological_process,response to axon injury;GO:0001764,biological_process,neuron migration","-"]
["EHF",14.18480576,2.689440042,2.395562969,5.250807713,{"v":1.12e-14,"d":"1.12E-14"},{"v":3.17e-13,"d":"3.17E-13"},"ENSG00000135373","A0A1D5QKT1,ETS homologous factor","XP_001115455.2,ETS homologous factor isoform X1","-","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR033071,ETS homologous factor;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000418,Ets domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR003118,Pointed domain","-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0003677,molecular_function,DNA binding;GO:0030855,biological_process,epithelial cell differentiation;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0050673,biological_process,epithelial cell proliferation;GO:0005634,cellular_component,nucleus","-"]
["RP11-109P14.9",42.06436859,7.957540809,2.395002217,4.209776985,{"v":6.53e-10,"d":"6.53E-10"},{"v":6.27e-09,"d":"6.27E-09"},"ENSG00000233728","G5C6H6,Glycoprotein endo-alpha-1,2-mannosidase-like protein","-","PF16317,lycosyl hydrolase family 99","IPR026071,Glycosyl hydrolase family 99","-","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds","-"]
["NIPAL2",5.258985179,0.994870257,2.395002217,4.209776985,{"v":6.53e-10,"d":"6.53E-10"},{"v":6.27e-09,"d":"6.27E-09"},"ENSG00000104361","H2RF73,Uncharacterized protein","-","PF05653,Magnesium transporter NIPA","-","-","-","-"]
["LRIG3",7.333742821,1.390053644,2.394508296,4.741090584,{"v":3.95e-12,"d":"3.95E-12"},{"v":6.23e-11,"d":"6.23E-11"},"ENSG00000139263","H2NHW0,Leucine rich repeats and immunoglobulin like domains 3","XP_002823502.1,leucine-rich repeats and immunoglobulin-like domains protein 3 isoform X1","PF13927,Immunoglobulin domain;PF13855,Leucine rich repeat;PF07679,Immunoglobulin I-set domain","IPR001611,Leucine-rich repeat;IPR007110,Immunoglobulin-like domain;IPR000483,Cysteine-rich flanking region, C-terminal;IPR032675,Leucine-rich repeat domain superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","KOG4194,Membrane glycoprotein LIG-1;KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0032474,biological_process,otolith morphogenesis;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SSH3",40.69627318,7.739372776,2.393182062,6.48055132,{"v":4.27e-20,"d":"4.27E-20"},{"v":3.51e-18,"d":"3.51E-18"},"ENSG00000172830","A0A024R5J4,Slingshot homolog 3","NP_060327.3,protein phosphatase Slingshot homolog 3","PF08766,K C terminal domain;PF00782,ual specificity phosphatase, catalytic domain","IPR029021,Protein-tyrosine phosphatase-like;IPR016130,Protein-tyrosine phosphatase, active site;IPR000340,Dual specificity phosphatase, catalytic domain;IPR020422,Dual specificity protein phosphatase domain;IPR000387,Tyrosine specific protein phosphatases domain;IPR024950,Dual specificity phosphatase;IPR014876,DEK, C-terminal","COG2453,Predicted protein-tyrosine phosphatase;KOG1716,Dual specificity phosphatase","GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","K05766,ko04360,Axon guidance;K05766,ko04810,Regulation of actin cytoskeleton"]
["UBAP2",19.29279847,3.670867065,2.392838964,6.94359236,{"v":7.32e-22,"d":"7.32E-22"},{"v":8.18e-20,"d":"8.18E-20"},"ENSG00000137073","K7CR84,Ubiquitin associated protein 2","-","PF12478,Ubiquitin-associated protein 2","IPR015940,Ubiquitin-associated domain;IPR009060,UBA-like superfamily;IPR022166,Protein of unknown function DUF3697, ubiquitin-associated protein 2","ENOG410IGWX,-;ENOG4110RI8,-","-","-"]
["KIAA0040",23.03606678,4.384373925,2.391536223,6.05924457,{"v":2.74e-18,"d":"2.74E-18"},{"v":1.66e-16,"d":"1.66E-16"},"ENSG00000235750","A0A024R935,KIAA0040, isoform CRA_a","XP_016858398.1,uncharacterized protein KIAA0040 isoform X1;XP_016858399.1,-","-","-","-","-","-"]
["NAF1",3.605364103,0.68149635,2.391152811,3.489526331,{"v":3.3e-07,"d":"3.30E-07"},{"v":1.72E-6,"d":"1.72E-06"},"ENSG00000145414","H2QQD4,Nuclear assembly factor 1 homolog","XP_009446765.1,-","PF04410,ar1/Naf1 RNA binding region","IPR007504,H/ACA ribonucleoprotein complex, subunit Gar1/Naf1;IPR038664,H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain;IPR009000,Translation protein, beta-barrel domain superfamily","ENOG4111RRE,-;KOG2236,Uncharacterized conserved protein","GO:1904358,biological_process,positive regulation of telomere maintenance via telomere lengthening;GO:0042254,biological_process,ribosome biogenesis;GO:0005732,cellular_component,small nucleolar ribonucleoprotein complex;GO:0090669,biological_process,telomerase RNA stabilization;GO:0070034,molecular_function,telomerase RNA binding;GO:0003723,molecular_function,RNA binding;GO:1904874,biological_process,positive regulation of telomerase RNA localization to Cajal body;GO:0051973,biological_process,positive regulation of telomerase activity;GO:0001522,biological_process,pseudouridine synthesis;GO:1905323,biological_process,telomerase holoenzyme complex assembly;GO:0005634,cellular_component,nucleus","-"]
["ZNF839",1.869095956,0.351696005,2.389644627,2.819427931,{"v":5.65e-05,"d":"5.65E-05"},0.000180914,"ENSG00000022976","G3QTB9,Zinc finger protein 839","XP_004055778.2,zinc finger protein 839 isoform X1","PF15961,omain of unknown function (DUF4764)","IPR013087,Zinc finger C2H2-type;IPR031885,Domain of unknown function DUF4764","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["CCNE1",4.097351526,0.770972812,2.389644627,2.819427931,{"v":5.65e-05,"d":"5.65E-05"},0.000180914,"ENSG00000105173","G3QZF2,Cyclin E1","XP_004060487.1,G1/S-specific cyclin-E1 isoform X1","PF02984,Cyclin, C-terminal domain;PF00134,Cyclin, N-terminal domain","IPR004367,Cyclin, C-terminal domain;IPR013763,Cyclin-like;IPR028858,Cyclin E;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","-","GO:0070192,biological_process,chromosome organization involved in meiotic cell cycle;GO:0019901,molecular_function,protein kinase binding;GO:0097134,cellular_component,cyclin E1-CDK2 complex;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0016055,biological_process,Wnt signaling pathway;GO:0016301,molecular_function,kinase activity;GO:0016538,molecular_function,cyclin-dependent protein serine/threonine kinase regulator activity;GO:0000082,biological_process,G1/S transition of mitotic cell cycle;GO:0006270,biological_process,DNA replication initiation;GO:0007129,biological_process,synapsis;GO:0045859,biological_process,regulation of protein kinase activity;GO:0051726,biological_process,regulation of cell cycle;GO:0000307,cellular_component,cyclin-dependent protein kinase holoenzyme complex;GO:0000723,biological_process,telomere maintenance;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:1903827,biological_process,regulation of cellular protein localization;GO:0005654,cellular_component,nucleoplasm","K06626,ko04114,Oocyte meiosis;K06626,ko05200,Pathways in cancer;K06626,ko05206,MicroRNAs in cancer;K06626,ko04151,PI3K-Akt signaling pathway;K06626,ko04115,p53 signaling pathway;K06626,ko05162,Measles;K06626,ko04391,Hippo signaling pathway - fly;K06626,ko05203,Viral carcinogenesis;K06626,ko05161,Hepatitis B;K06626,ko05222,Small cell lung cancer;K06626,ko05215,Prostate cancer;K06626,ko04110,Cell cycle"]
["TLR3",1.553873646,0.29238261,2.389644627,2.819427931,{"v":5.65e-05,"d":"5.65E-05"},0.000180914,"ENSG00000164342","G3SGL1,Toll like receptor 3","XP_018880459.1,toll-like receptor 3 isoform X1","PF01582,TIR domain;PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR027173,Toll-like receptor 3;IPR000483,Cysteine-rich flanking region, C-terminal;IPR032675,Leucine-rich repeat domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR035897,Toll/interleukin-1 receptor homology (TIR) domain superfamily;IPR000157,Toll/interleukin-1 receptor homology (TIR) domain","-","GO:0051607,biological_process,defense response to virus;GO:0050729,biological_process,positive regulation of inflammatory response;GO:0002756,biological_process,MyD88-independent toll-like receptor signaling pathway;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0045087,biological_process,innate immune response;GO:0016020,cellular_component,membrane;GO:0043330,biological_process,response to exogenous dsRNA;GO:0007165,biological_process,signal transduction;GO:0001819,biological_process,positive regulation of cytokine production;GO:0003725,molecular_function,double-stranded RNA binding;GO:0032722,biological_process,positive regulation of chemokine production;GO:0002376,biological_process,immune system process;GO:0016021,cellular_component,integral component of membrane;GO:0034138,biological_process,toll-like receptor 3 signaling pathway","-"]
["MKL2",7.978362946,1.521901633,2.388626168,6.319452705,1.93E-19,{"v":1.46e-17,"d":"1.46E-17"},"ENSG00000186260","G1RGX6,MKL1/myocardin like 2","XP_003269349.1,MKL/myocardin-like protein 2 isoform X1;XP_012352861.1,-","PF02037,SAP domain;PF02755,RPEL repeat","IPR036361,SAP domain superfamily;IPR004018,RPEL repeat;IPR003034,SAP domain","ENOG410IFJX,-;ENOG41101AM,-","GO:0045844,biological_process,positive regulation of striated muscle tissue development;GO:0003713,molecular_function,transcription coactivator activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0045296,molecular_function,cadherin binding","-"]
["CHERP",20.51021703,3.912879354,2.388361671,6.243400723,{"v":3.74e-19,"d":"3.74E-19"},2.63E-17,"ENSG00000085872","J3QK89,Calcium homeostasis endoplasmic reticulum protein","-","PF04818,RNA polymerase II-binding domain.;PF01805,Surp module;PF01585,-patch domain","IPR006903,RNA polymerase II-binding domain;IPR008942,ENTH/VHS;IPR000467,G-patch domain;IPR035967,SWAP/Surp superfamily;IPR000061,SWAP/Surp;IPR006569,CID domain","KOG4368,Predicted RNA binding protein, contains SWAP, RPR and G-patch domains;ENOG410YVN1,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0006396,biological_process,RNA processing","-"]
["ZNF33B",4.973885311,0.946662174,2.388352118,4.6794309609999996,{"v":3.94e-12,"d":"3.94E-12"},{"v":6.21e-11,"d":"6.21E-11"},"ENSG00000196693","Q3B799,ZNF33B protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["FGFRL1",12.43156852,2.37150865,2.386051762,4.987918219,{"v":3.03e-13,"d":"3.03E-13"},{"v":6.27e-12,"d":"6.27E-12"},"ENSG00000127418","K7ASX4,Fibroblast growth factor receptor-like 1","XP_016808197.1,-;XP_016808199.1,-;XP_016808198.1,-;XP_016808201.1,-","PF13927,Immunoglobulin domain;PF07679,Immunoglobulin I-set domain","IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","-","GO:0008543,biological_process,fibroblast growth factor receptor signaling pathway;GO:0005794,cellular_component,Golgi apparatus;GO:0016021,cellular_component,integral component of membrane;GO:0003179,biological_process,heart valve morphogenesis;GO:0001501,biological_process,skeletal system development;GO:0098742,biological_process,cell-cell adhesion via plasma-membrane adhesion molecules;GO:0044291,cellular_component,cell-cell contact zone;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0017134,molecular_function,fibroblast growth factor binding;GO:0030133,cellular_component,transport vesicle;GO:0051260,biological_process,protein homooligomerization;GO:0005007,molecular_function,fibroblast growth factor-activated receptor activity;GO:0005886,cellular_component,plasma membrane;GO:0060412,biological_process,ventricular septum morphogenesis;GO:0008201,molecular_function,heparin binding;GO:0016020,cellular_component,membrane;GO:0060539,biological_process,diaphragm development","-"]
["ANTXR1",7.33994096,1.401126521,2.385683979,5.203180179,2.75E-14,{"v":7.07e-13,"d":"7.07E-13"},"ENSG00000169604","G1RGD9,Anthrax toxin receptor 1","XP_012356667.1,-","PF05586,Anthrax receptor C-terminus region;PF05587,Anthrax receptor extracellular domain;PF00092,von Willebrand factor type A domain","IPR008399,Anthrax toxin receptor, C-terminal;IPR002035,von Willebrand factor, type A;IPR008400,Anthrax toxin receptor, extracellular;IPR036465,von Willebrand factor A-like domain superfamily","ENOG410YC57,-;ENOG410IK1W,-","GO:0009986,cellular_component,cell surface;GO:0016021,cellular_component,integral component of membrane;GO:0007165,biological_process,signal transduction;GO:0031258,cellular_component,lamellipodium membrane;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0009897,cellular_component,external side of plasma membrane;GO:1905050,biological_process,positive regulation of metallopeptidase activity;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0005518,molecular_function,collagen binding;GO:0022414,biological_process,reproductive process;GO:1901202,biological_process,negative regulation of extracellular matrix assembly;GO:0001568,biological_process,blood vessel development;GO:0016020,cellular_component,membrane;GO:0051015,molecular_function,actin filament binding;GO:0034446,biological_process,substrate adhesion-dependent cell spreading;GO:0004872,-,-;GO:0031527,cellular_component,filopodium membrane","-"]
["ZNF384",24.79558745,4.743246165,2.384503972,6.278609193,{"v":3.92e-19,"d":"3.92E-19"},{"v":2.73e-17,"d":"2.73E-17"},"ENSG00000126746","G3SBS1,Zinc finger protein 384","XP_018894580.1,zinc finger protein 384 isoform X4","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["ZSCAN20",2.281550002,0.432110798,2.383146243,3.013520446,{"v":1.35e-05,"d":"1.35E-05"},{"v":4.98e-05,"d":"4.98E-05"},"ENSG00000121903","H2R053,Uncharacterized protein","XP_016814201.1,-;XP_009451609.2,zinc finger and SCAN domain-containing protein 20 isoform X1","PF00096,Zinc finger, C2H2 type;PF13837,Myb/SANT-like DNA-binding domain;PF02023,SCAN domain","IPR013087,Zinc finger C2H2-type;IPR003309,SCAN domain;IPR038269,SCAN domain superfamily;IPR036236,Zinc finger C2H2 superfamily;IPR001005,SANT/Myb domain","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["CNEP1R1",2.89862791,0.548981358,2.383146243,3.013520446,{"v":1.35e-05,"d":"1.35E-05"},{"v":4.98e-05,"d":"4.98E-05"},"ENSG00000205423","H2RHL6,Transmembrane protein 188","XP_001164100.1,-","PF09771,Transmembrane protein 188","IPR019168,Nuclear envelope phosphatase-regulatory subunit 1","KOG4606,Uncharacterized conserved protein;ENOG4111N81,-","GO:0010867,biological_process,positive regulation of triglyceride biosynthetic process;GO:0034504,biological_process,protein localization to nucleus;GO:0005737,cellular_component,cytoplasm;GO:0035307,biological_process,positive regulation of protein dephosphorylation;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol;GO:0071595,cellular_component,Nem1-Spo7 phosphatase complex","-"]
["NRCAM",1.478148103,0.27995168,2.383146243,3.013520446,{"v":1.35e-05,"d":"1.35E-05"},{"v":4.98e-05,"d":"4.98E-05"},"ENSG00000091129","F8W775,Neuronal cell adhesion molecule","-","PF13927,Immunoglobulin domain;PF00041,ibronectin type III domain;PF13882,Bravo-like intracellular region;PF07679,Immunoglobulin I-set domain","IPR026966,Neurofascin/L1/NrCAM, C-terminal domain;IPR003961,Fibronectin type III;IPR003006,Immunoglobulin/major histocompatibility complex, conserved site;IPR036116,Fibronectin type III superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR007110,Immunoglobulin-like domain;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","KOG3513,Neural cell adhesion molecule L1;ENOG410XSVG,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MTOR-AS1",4.668285949,0.858881901,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000225602","A0A0P6JH97,Serine/threonine-protein kinase mTOR","XP_004863641.1,serine/threonine-protein kinase mTOR","PF02259,AT domain;PF08771,KBP12-rapamycin binding domain;PF11865,omain of unknown function (DUF3385);PF02260,ATC domain;PF00454,Phosphatidylinositol 3- and 4-kinase","IPR009076,FKBP12-rapamycin binding domain;IPR018936,Phosphatidylinositol 3/4-kinase, conserved site;IPR026683,Serine/threonine-protein kinase TOR;IPR003152,FATC domain;IPR000403,Phosphatidylinositol 3-/4-kinase, catalytic domain;IPR036738,FKBP12-rapamycin binding domain superfamily;IPR014009,PIK-related kinase;IPR011989,Armadillo-like helical;IPR011009,Protein kinase-like domain superfamily;IPR024585,Domain of unknown function DUF3385,  target of rapamycin protein;IPR016024,Armadillo-type fold;IPR003151,PIK-related kinase, FAT;IPR036940,Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily","-","GO:0007584,biological_process,response to nutrient;GO:0031641,biological_process,regulation of myelination;GO:0003007,biological_process,heart morphogenesis;GO:0051534,-,-;GO:0055006,biological_process,cardiac cell development;GO:0051896,biological_process,regulation of protein kinase B signaling;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0010592,biological_process,positive regulation of lamellipodium assembly;GO:0006207,biological_process,'de novo' pyrimidine nucleobase biosynthetic process;GO:0038202,biological_process,TORC1 signaling;GO:0071233,biological_process,cellular response to leucine;GO:0032868,biological_process,response to insulin;GO:0035264,biological_process,multicellular organism growth;GO:0048714,biological_process,positive regulation of oligodendrocyte differentiation;GO:0031529,biological_process,ruffle organization;GO:0009267,biological_process,cellular response to starvation;GO:0030030,biological_process,cell projection organization;GO:0004672,molecular_function,protein kinase activity;GO:0001156,molecular_function,TFIIIC-class transcription factor binding;GO:0043200,biological_process,response to amino acid;GO:0010507,biological_process,negative regulation of autophagy;GO:0005634,cellular_component,nucleus;GO:0008361,biological_process,regulation of cell size;GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:0016301,molecular_function,kinase activity;GO:0071456,biological_process,cellular response to hypoxia;GO:0001558,biological_process,regulation of cell growth;GO:0007281,biological_process,germ cell development;GO:0016605,cellular_component,PML body;GO:0005737,cellular_component,cytoplasm;GO:0045945,biological_process,positive regulation of transcription by RNA polymerase III;GO:0001030,molecular_function,RNA polymerase III type 1 promoter DNA binding;GO:0055013,biological_process,cardiac muscle cell development;GO:0044877,molecular_function,protein-containing complex binding;GO:0043022,molecular_function,ribosome binding;GO:0043087,biological_process,regulation of GTPase activity;GO:0005524,molecular_function,ATP binding;GO:0046889,biological_process,positive regulation of lipid biosynthetic process;GO:0016310,biological_process,phosphorylation;GO:0005829,cellular_component,cytosol;GO:0050882,biological_process,voluntary musculoskeletal movement;GO:0042802,molecular_function,identical protein binding;GO:1903691,biological_process,positive regulation of wound healing, spreading of epidermal cells;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0031931,cellular_component,TORC1 complex;GO:0031929,biological_process,TOR signaling;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0010628,biological_process,positive regulation of gene expression;GO:0030425,cellular_component,dendrite;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0001032,molecular_function,RNA polymerase III type 3 promoter DNA binding;GO:0090559,biological_process,regulation of membrane permeability;GO:0016740,molecular_function,transferase activity;GO:0045792,biological_process,negative regulation of cell size;GO:0031932,cellular_component,TORC2 complex;GO:0010831,biological_process,positive regulation of myotube differentiation;GO:0060048,biological_process,cardiac muscle contraction;GO:0045670,biological_process,regulation of osteoclast differentiation;GO:0003179,biological_process,heart valve morphogenesis;GO:0016020,cellular_component,membrane;GO:0009791,biological_process,post-embryonic development;GO:0031669,biological_process,cellular response to nutrient levels;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0045859,biological_process,regulation of protein kinase activity;GO:0030838,biological_process,positive regulation of actin filament polymerization;GO:0051549,biological_process,positive regulation of keratinocyte migration;GO:0006112,biological_process,energy reserve metabolic process;GO:0012505,cellular_component,endomembrane system;GO:0051496,biological_process,positive regulation of stress fiber assembly;GO:0016242,biological_process,negative regulation of macroautophagy;GO:0001031,molecular_function,RNA polymerase III type 2 promoter DNA binding;GO:0048738,biological_process,cardiac muscle tissue development;GO:0005764,cellular_component,lysosome;GO:0046777,biological_process,protein autophosphorylation;GO:0071230,biological_process,cellular response to amino acid stimulus;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0018107,biological_process,peptidyl-threonine phosphorylation;GO:1901838,biological_process,positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0051219,molecular_function,phosphoprotein binding;GO:0001934,biological_process,positive regulation of protein phosphorylation;GO:1990253,biological_process,cellular response to leucine starvation;GO:0045727,biological_process,positive regulation of translation;GO:0034198,biological_process,cellular response to amino acid starvation","K07203,ko01522,Endocrine resistance;K07203,ko04139,Regulation of mitophagy - yeast;K07203,ko05215,Prostate cancer;K07203,ko04072,Phospholipase D signaling pathway;K07203,ko04151,PI3K-Akt signaling pathway;K07203,ko01521,EGFR tyrosine kinase inhibitor resistance;K07203,ko05230,Central carbon metabolism in cancer;K07203,ko04920,Adipocytokine signaling pathway;K07203,ko04919,Thyroid hormone signaling pathway;K07203,ko04012,ErbB signaling pathway;K07203,ko05214,Glioma;K07203,ko04212,Longevity regulating pathway - worm;K07203,ko04213,Longevity regulating pathway - multiple species;K07203,ko04152,AMPK signaling pathway;K07203,ko04910,Insulin signaling pathway;K07203,ko04150,mTOR signaling pathway;K07203,ko05206,MicroRNAs in cancer;K07203,ko05221,Acute myeloid leukemia;K07203,ko04930,Type II diabetes mellitus;K07203,ko04630,Jak-STAT signaling pathway;K07203,ko05231,Choline metabolism in cancer;K07203,ko04066,HIF-1 signaling pathway;K07203,ko05205,Proteoglycans in cancer;K07203,ko04211,Longevity regulating pathway;K07203,ko04931,Insulin resistance;K07203,ko05200,Pathways in cancer"]
["MSTO1",0.846459643,0.155733577,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000125459","H2Q082,Misato 1, mitochondrial distribution and morphology regulator","-","PF10644,Misato Segment II tubulin-like domain;PF14881,Tubulin domain","-","-","-","-"]
["RP11-80H5.5",5.735752302,1.055276796,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000249962","G3QFR3,Pantothenate kinase 1","XP_004049820.1,pantothenate kinase 1 isoform X1","PF03630,umble","IPR004567,Type II pantothenate kinase","-","GO:0016310,biological_process,phosphorylation;GO:0004594,molecular_function,pantothenate kinase activity;GO:0005524,molecular_function,ATP binding;GO:0071944,cellular_component,cell periphery;GO:0055037,cellular_component,recycling endosome;GO:0005829,cellular_component,cytosol;GO:0030118,cellular_component,clathrin coat;GO:0005634,cellular_component,nucleus;GO:0015937,biological_process,coenzyme A biosynthetic process","K09680,ko00770,Pantothenate and CoA biosynthesis"]
["RP11-18I14.11",6.836664452,1.257825125,2.382382726,1.492720732,0.026470701,0.04485081,"-","-","-","-","-","-","-","-"]
["MAP1A",0.335111692,0.061654614,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000166963","E9PGC8,Microtubule-associated protein 1A","XP_016877678.1,microtubule-associated protein 1A isoform X1","-","IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR026074,Microtubule associated protein 1;IPR015656,Microtubule associated protein 1A","ENOG410XRYM,-;KOG3592,Microtubule-associated proteins","GO:0005874,cellular_component,microtubule;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0008017,molecular_function,microtubule binding","-"]
["PRSS27",0.601571049,0.110678414,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000172382","H2QAE0,Uncharacterized protein","XP_510751.2,serine protease 27 isoform X1;XP_009428391.1,-;XP_016802228.1,-","PF00089,Trypsin","IPR001254,Serine proteases, trypsin domain;IPR018114,Serine proteases, trypsin family, histidine active site;IPR001314,Peptidase S1A, chymotrypsin family;IPR009003,Peptidase S1, PA clan;IPR033116,Serine proteases, trypsin family, serine active site","KOG3627,Trypsin;COG5640,Secreted trypsin-like serine protease","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0046658,cellular_component,anchored component of plasma membrane;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0008236,molecular_function,serine-type peptidase activity;GO:0019897,cellular_component,extrinsic component of plasma membrane;GO:0008233,molecular_function,peptidase activity","-"]
["RP13-580F15.2",3.363458148,0.618816705,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000262823","G7MFZ1,Uncharacterized protein","-","-","-","-","-","-"]
["RP11-589P10.7",7.152414015,1.31591745,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000267047","G3S2S6,Uncharacterized protein","-","-","-","-","-","-"]
["RNASEH1P1",4.80040725,0.883189879,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000265790","H2QHD3,Ribonuclease H1","NP_001272946.1,ribonuclease H1 precursor","PF01693,Caulimovirus viroplasmin;PF00075,RNase H","IPR017067,Ribonuclease H1, eukaryote;IPR036397,Ribonuclease H superfamily;IPR002156,Ribonuclease H domain;IPR011320,Ribonuclease H1, N-terminal;IPR012337,Ribonuclease H-like superfamily;IPR009027,Ribosomal protein L9/RNase H1, N-terminal;IPR037056,Ribonuclease H1, N-terminal domain superfamily","COG0328,Ribonuclease HI;KOG3752,Ribonuclease H","GO:0016787,molecular_function,hydrolase activity;GO:0004523,molecular_function,RNA-DNA hybrid ribonuclease activity;GO:0003676,molecular_function,nucleic acid binding;GO:0043137,biological_process,DNA replication, removal of RNA primer;GO:0000287,molecular_function,magnesium ion binding;GO:0004518,molecular_function,nuclease activity;GO:0046872,molecular_function,metal ion binding;GO:0004519,molecular_function,endonuclease activity;GO:0005634,cellular_component,nucleus;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic","K03469,ko03030,DNA replication"]
["DTNA",0.281929886,0.051870104,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000134769","H2R3Y4,Dystrobrevin","XP_009432143.1,dystrobrevin alpha isoform X7","PF00569,Zinc finger, ZZ type;PF09068,hand;PF09069,-hand","IPR011992,EF-hand domain pair;IPR000433,Zinc finger, ZZ-type;IPR015154,EF-hand domain, type 2;IPR015153,EF-hand domain, type 1;IPR017432,Distrobrevin","ENOG410XP3C,-;KOG4301,Beta-dystrobrevin","GO:0005737,cellular_component,cytoplasm;GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding","-"]
["CTD-3222D19.11",8.245143933,1.516960394,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000268309","G7PEQ3,Uncharacterized protein","-","-","-","-","-","-"]
["GALNT5",0.522426251,0.096117174,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000136542","H2QIU5,Polypeptide N-acetylgalactosaminyltransferase","XP_525944.2,polypeptide N-acetylgalactosaminyltransferase 5","PF00535,lycosyl transferase family 2;PF00652,Ricin-type beta-trefoil lectin domain","IPR035992,Ricin B-like lectins;IPR000772,Ricin B, lectin domain;IPR029044,Nucleotide-diphospho-sugar transferases;IPR001173,Glycosyltransferase 2-like","ENOG410XPMK,-;KOG3736,Polypeptide N-acetylgalactosaminyltransferase","GO:0005794,cellular_component,Golgi apparatus;GO:0006486,biological_process,protein glycosylation;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity;GO:0030246,molecular_function,carbohydrate binding;GO:0004653,molecular_function,polypeptide N-acetylgalactosaminyltransferase activity;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K00710,ko00512,Mucin type O-Glycan biosynthesis"]
["GRB14",1.204158952,0.221543911,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000115290","K7DBZ2,Growth factor receptor-bound protein 14","-","PF00788,Ras association (RalGDS/AF-6) domain;PF08947,BPS (Between PH and SH2);PF00017,SH2 domain;PF00169,PH domain","-","-","-","-"]
["FTH1P20",6.499821495,1.195851989,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000226564","G3RMF9,Ferritin","XP_004051373.1,-","PF00210,erritin-like domain","IPR008331,Ferritin/DPS protein domain;IPR012347,Ferritin-like;IPR009040,Ferritin-like diiron domain;IPR001519,Ferritin;IPR009078,Ferritin-like superfamily;IPR014034,Ferritin, conserved site","-","GO:0005623,cellular_component,cell;GO:0008199,molecular_function,ferric iron binding;GO:0046872,molecular_function,metal ion binding;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0006826,biological_process,iron ion transport","-"]
["WDFY3-AS2",0.574222502,0.105646766,2.382382726,1.492720732,0.026470701,0.04485081,"-","-","-","-","-","-","-","-"]
["STARD4-AS1",0.630760081,0.116048679,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000246859","M3YPU3,Uncharacterized protein","-","-","-","-","-","-"]
["RP11-360L9.4",6.371918031,1.172320018,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000253133","B4DRD5,cDNA FLJ50176, moderately similar to Homo sapiens SLD5 homolog","-","PF16922,NA replication complex GINS protein SLD5 C-terminus","IPR031633,DNA replication complex GINS protein SLD5, C-terminal;IPR008591,GINS complex subunit Sld5","-","GO:0006261,biological_process,DNA-dependent DNA replication","-"]
["RP3-368A4.5",0.914011337,0.168161891,2.382382726,1.492720732,0.026470701,0.04485081,"ENSG00000271430","G3QVU0,RAB11 family interacting protein 1","-","PF09457,IP domain","IPR019018,Rab-binding domain FIP-RBD;IPR037245,FIP-RBD, C-terminal domain superfamily;IPR037789,Rab11-family interacting protein class I","-","GO:0017137,molecular_function,Rab GTPase binding","-"]
["ICMT",16.00800572,3.069759363,2.37993691,5.582598269,{"v":4.33e-16,"d":"4.33E-16"},{"v":1.69e-14,"d":"1.69E-14"},"ENSG00000116237","A0A024R4F6,Protein-S-isoprenylcysteine O-methyltransferase","NP_036537.1,protein-S-isoprenylcysteine O-methyltransferase","PF04140,Isoprenylcysteine carboxyl methyltransferase (ICMT) family","IPR007269,Isoprenylcysteine carboxyl methyltransferase;IPR025770,Protein-S-isoprenylcysteine O-methyltransferase","COG2020,Putative protein-S-isoprenylcysteine methyltransferase;KOG2628,Farnesyl cysteine-carboxyl methyltransferase","GO:0004671,molecular_function,protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity;GO:0006481,biological_process,C-terminal protein methylation;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0008168,molecular_function,methyltransferase activity;GO:0016020,cellular_component,membrane;GO:0032259,biological_process,methylation;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane","K00587,ko00900,Terpenoid backbone biosynthesis"]
["INTS7",4.515811462,0.863733427,2.377611516,3.931166668,{"v":9.32e-09,"d":"9.32E-09"},{"v":6.91e-08,"d":"6.91E-08"},"ENSG00000143493","K7C8A0,Integrator complex subunit 7","-","-","IPR016024,Armadillo-type fold;IPR033060,Integrator complex subunit 7","KOG1988,Uncharacterized conserved protein;ENOG410XSMR,-","GO:0032039,cellular_component,integrator complex;GO:0016180,biological_process,snRNA processing","-"]
["RP11-804A23.2",47.87120693,9.156263934,2.377611516,3.931166668,{"v":9.32e-09,"d":"9.32E-09"},{"v":6.91e-08,"d":"6.91E-08"},"ENSG00000255959","G1RT87,Coiled-coil domain containing 86","XP_003275281.1,coiled-coil domain-containing protein 86 isoform X1","PF03879,Cgr1 family","IPR026570,Coiled-coil domain-containing protein 86;IPR005579,Cgr1-like","ENOG41129IK,-;KOG4538,Predicted coiled-coil protein","GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus","-"]
["PDE4D",2.099610765,0.402386645,2.377361302,4.418565215,{"v":1.38e-10,"d":"1.38E-10"},{"v":1.52e-09,"d":"1.52E-09"},"ENSG00000113448","A0A140VJR0,Phosphodiesterase","NP_001098101.1,cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D4","PF00233,3'5'-cyclic nucleotide phosphodiesterase","IPR003607,HD/PDEase domain;IPR023088,3'5'-cyclic nucleotide phosphodiesterase;IPR023174,3'5'-cyclic nucleotide phosphodiesterase, conserved site;IPR002073,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain;IPR036971,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily","-","GO:0004114,molecular_function,3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0033137,biological_process,negative regulation of peptidyl-serine phosphorylation;GO:1901898,biological_process,negative regulation of relaxation of cardiac muscle;GO:0035264,biological_process,multicellular organism growth;GO:0005886,cellular_component,plasma membrane;GO:0004115,molecular_function,3',5'-cyclic-AMP phosphodiesterase activity;GO:0010880,biological_process,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0034704,cellular_component,calcium channel complex;GO:0016787,molecular_function,hydrolase activity;GO:0006939,biological_process,smooth muscle contraction;GO:0050900,biological_process,leukocyte migration;GO:0030593,biological_process,neutrophil chemotaxis;GO:0086004,biological_process,regulation of cardiac muscle cell contraction;GO:0005813,cellular_component,centrosome;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0005829,cellular_component,cytosol;GO:0051117,molecular_function,ATPase binding;GO:0071872,biological_process,cellular response to epinephrine stimulus;GO:0030814,biological_process,regulation of cAMP metabolic process;GO:0045822,biological_process,negative regulation of heart contraction;GO:0060314,biological_process,regulation of ryanodine-sensitive calcium-release channel activity;GO:0031965,cellular_component,nuclear membrane;GO:0002027,biological_process,regulation of heart rate;GO:0007165,biological_process,signal transduction;GO:0044325,molecular_function,ion channel binding;GO:0006198,biological_process,cAMP catabolic process;GO:0046872,molecular_function,metal ion binding;GO:0005891,cellular_component,voltage-gated calcium channel complex;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0007568,biological_process,aging","K13293,ko05032,Morphine addiction;K13293,ko00230,Purine metabolism;K13293,ko04024,cAMP signaling pathway"]
["RIPK2",14.24608507,2.733156744,2.377226089,4.781414668,{"v":2.5e-12,"d":"2.50E-12"},{"v":4.1e-11,"d":"4.10E-11"},"ENSG00000104312","A0A0S2Z4Z8,Receptor-interacting serine-threonine kinase 2 isoform 1","NP_003812.1,receptor-interacting serine/threonine-protein kinase 2","PF00619,Caspase recruitment domain;PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR017322,Receptor-interacting serine/threonine-protein kinase 2;IPR011029,Death-like domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR001315,CARD domain;IPR000719,Protein kinase domain","-","GO:0034142,biological_process,toll-like receptor 4 signaling pathway;GO:0001961,biological_process,positive regulation of cytokine-mediated signaling pathway;GO:0032743,biological_process,positive regulation of interleukin-2 production;GO:0032760,biological_process,positive regulation of tumor necrosis factor production;GO:0004672,molecular_function,protein kinase activity;GO:0045627,biological_process,positive regulation of T-helper 1 cell differentiation;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032755,biological_process,positive regulation of interleukin-6 production;GO:0050852,biological_process,T cell receptor signaling pathway;GO:0016301,molecular_function,kinase activity;GO:0031663,biological_process,lipopolysaccharide-mediated signaling pathway;GO:0070555,biological_process,response to interleukin-1;GO:0007249,biological_process,I-kappaB kinase/NF-kappaB signaling;GO:0016310,biological_process,phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0005829,cellular_component,cytosol;GO:0070427,biological_process,nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0046330,biological_process,positive regulation of JNK cascade;GO:0002250,biological_process,adaptive immune response;GO:0032874,biological_process,positive regulation of stress-activated MAPK cascade;GO:0042981,biological_process,regulation of apoptotic process;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:1904417,biological_process,positive regulation of xenophagy;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity;GO:0070671,biological_process,response to interleukin-12;GO:0032729,biological_process,positive regulation of interferon-gamma production;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0071224,biological_process,cellular response to peptidoglycan;GO:0050830,biological_process,defense response to Gram-positive bacterium;GO:0070673,biological_process,response to interleukin-18;GO:0071223,biological_process,cellular response to lipoteichoic acid;GO:0002827,biological_process,positive regulation of T-helper 1 type immune response;GO:0045087,biological_process,innate immune response;GO:0042098,biological_process,T cell proliferation;GO:0070431,biological_process,nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0005737,cellular_component,cytoplasm;GO:0043330,biological_process,response to exogenous dsRNA;GO:0033091,biological_process,positive regulation of immature T cell proliferation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0046641,biological_process,positive regulation of alpha-beta T cell proliferation;GO:0032722,biological_process,positive regulation of chemokine production;GO:0043065,biological_process,positive regulation of apoptotic process","K08846,ko05152,Tuberculosis;K08846,ko05131,Shigellosis;K08846,ko04621,NOD-like receptor signaling pathway;K08846,ko04722,Neurotrophin signaling pathway"]
["TRERF1",8.384198094,1.610348023,2.377083392,5.311443153,{"v":7.14e-15,"d":"7.14E-15"},{"v":2.12e-13,"d":"2.12E-13"},"ENSG00000124496","Q05GC8,Breast cancer anti-estrogen resistance 2","NP_001284502.1,transcriptional-regulating factor 1 isoform 1;NP_277037.1,transcriptional-regulating factor 1 isoform 2;XP_016866537.1,-","PF01448,LM2 domain;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR001005,SANT/Myb domain;IPR000949,ELM2 domain;IPR017884,SANT domain;IPR009057,Homeobox-like domain superfamily","ENOG4110BKZ,-;KOG4167,Predicted DNA-binding protein, contains SANT and ELM2 domains","GO:0003677,molecular_function,DNA binding;GO:0005730,cellular_component,nucleolus;GO:0003676,molecular_function,nucleic acid binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["MUC16",8.337922966,1.607292738,2.374486485,7.775392347,{"v":4.32e-24,"d":"4.32E-24"},6.82E-22,"ENSG00000181143","G3S1E5,Uncharacterized protein","-","-","-","-","-","-"]
["PRMT6",5.900194741,1.127282495,2.374385548,3.336307599,{"v":1.6e-06,"d":"1.60E-06"},{"v":7.27e-06,"d":"7.27E-06"},"ENSG00000198890","A0A0D9SAE2,Protein arginine methyltransferase 6","XP_007975970.1,-","PF13649,Methyltransferase domain;PF05175,Methyltransferase small domain;PF08003,Protein of unknown function (DUF1698);PF06325,Ribosomal protein L11 methyltransferase (PrmA);PF02475,Met-10+ like-protein;PF08241,Methyltransferase domain","IPR025799,Protein arginine N-methyltransferase;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase","-","GO:0008469,molecular_function,histone-arginine N-methyltransferase activity;GO:0035241,molecular_function,protein-arginine omega-N monomethyltransferase activity;GO:0042393,molecular_function,histone binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0090398,biological_process,cellular senescence;GO:0034970,biological_process,histone H3-R2 methylation;GO:0005634,cellular_component,nucleus;GO:0042054,molecular_function,histone methyltransferase activity;GO:0019919,biological_process,peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0070611,molecular_function,histone methyltransferase activity (H3-R2 specific);GO:0006479,biological_process,protein methylation;GO:0032259,biological_process,methylation;GO:0016571,biological_process,histone methylation;GO:0003682,molecular_function,chromatin binding;GO:0044020,molecular_function,histone methyltransferase activity (H4-R3 specific);GO:0016740,molecular_function,transferase activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0043985,biological_process,histone H4-R3 methylation;GO:0005730,cellular_component,nucleolus;GO:0035242,molecular_function,protein-arginine omega-N asymmetric methyltransferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0070612,molecular_function,histone methyltransferase activity (H2A-R3 specific);GO:0016274,molecular_function,protein-arginine N-methyltransferase activity","-"]
["ABCB10",3.626623459,0.692897323,2.374385548,3.336307599,{"v":1.6e-06,"d":"1.60E-06"},{"v":7.27e-06,"d":"7.27E-06"},"ENSG00000135776","G3S798,ATP binding cassette subfamily B member 10","XP_004028608.2,ATP-binding cassette sub-family B member 10, mitochondrial","PF00005,ABC transporter;PF00664,ABC transporter transmembrane region","IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR011527,ABC transporter type 1, transmembrane domain;IPR030260,ATP-binding cassette subfamily B member 10-like;IPR036640,ABC transporter type 1, transmembrane domain superfamily;IPR003593,AAA+ ATPase domain;IPR017871,ABC transporter, conserved site","-","GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0055085,biological_process,transmembrane transport;GO:0016887,molecular_function,ATPase activity;GO:0016020,cellular_component,membrane;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","-"]
["VEZF1",34.60644495,6.669314982,2.374207566,6.679716739,{"v":9.74e-21,"d":"9.74E-21"},{"v":9.01e-19,"d":"9.01E-19"},"ENSG00000136451","U3FX40,Vascular endothelial zinc finger 1","-","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["MED15",44.63536565,8.622722239,2.371524141,8.115800163,7.77E-25,1.37E-22,"ENSG00000099917","H2QZT1,Uncharacterized protein","XP_016794289.1,mediator of RNA polymerase II transcription subunit 15 isoform X4;XP_016794293.1,-","PF09606,ARC105 or Med15 subunit of Mediator complex non-fungal","IPR019087,Mediator of RNA polymerase II transcription subunit 15","KOG4274,Positive cofactor 2 (PC2), subunit of a multiprotein coactivator of RNA polymerase II;ENOG410YKAW,-","GO:0016592,cellular_component,mediator complex;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component,nucleus","-"]
["BIVM",3.130769174,0.600006309,2.371292961,3.47372107,{"v":4.66e-07,"d":"4.66E-07"},{"v":2.36e-06,"d":"2.36E-06"},"ENSG00000134897","G3RDY0,Basic, immunoglobulin-like variable motif containing","XP_004054758.1,basic immunoglobulin-like variable motif-containing protein isoform X1;XP_018895246.1,-;XP_018895247.1,-","-","-","-","-","-"]
["RP11-481J2.4",19.58434188,3.753304067,2.371292961,3.47372107,{"v":4.66e-07,"d":"4.66E-07"},{"v":2.36e-06,"d":"2.36E-06"},"ENSG00000276259","Q4R5J6,Brain cDNA, clone: QflA-12119, similar to human hypothetical protein FLJ20344","NP_001335372.1,-;NP_001335371.1,KRAB domain-containing protein 4 isoform 1","-","-","-","-","-"]
["PXDC1",6.910723711,1.32442783,2.371292961,3.47372107,{"v":4.66e-07,"d":"4.66E-07"},{"v":2.36e-06,"d":"2.36E-06"},"ENSG00000168994","G3QDX5,PX domain containing 1","XP_004043257.1,PX domain-containing protein 1","PF00787,PX domain","IPR036871,PX domain superfamily;IPR001683,Phox homologous domain","-","GO:0035091,molecular_function,phosphatidylinositol binding","-"]
["DAG1",27.4401439,5.3009253,2.370880801,6.83869138,{"v":2.83e-21,"d":"2.83E-21"},{"v":2.9E-19,"d":"2.90E-19"},"ENSG00000173402","A0A024R2W4,Dystroglycan 1","NP_001171112.1,-;NP_001171108.1,-;NP_001171111.1,-;NP_001171109.1,-;NP_001171114.1,-;NP_001171107.1,-;NP_001171106.1,-;NP_001171110.1,-;NP_001171115.1,-;NP_001171113.1,-;NP_001171105.1,-;NP_001159400.2,-;NP_004384.4,dystroglycan preproprotein","PF05454,ystroglycan (Dystrophin-associated glycoprotein 1)","IPR008465,Dystroglycan;IPR015919,Cadherin-like;IPR030398,DG-type SEA domain;IPR013783,Immunoglobulin-like fold;IPR006644,Dystroglycan-type cadherin-like;IPR027468,Alpha-dystroglycan domain 2","KOG3781,Dystroglycan;ENOG410XQTU,-","GO:0007016,biological_process,cytoskeletal anchoring at plasma membrane;GO:0016010,cellular_component,dystrophin-associated glycoprotein complex;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005509,molecular_function,calcium ion binding","K06265,ko04512,ECM-receptor interaction;K06265,ko05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);K06265,ko05410,Hypertrophic cardiomyopathy (HCM);K06265,ko05414,Dilated cardiomyopathy;K06265,ko05416,Viral myocarditis"]
["TRIQK",8.087206019,1.559373921,2.370859113,5.065584544,{"v":1.14e-13,"d":"1.14E-13"},{"v":2.58e-12,"d":"2.58E-12"},"ENSG00000205133","H2PQS9,Triple QxxK/R motif-containing protein","XP_009242201.1,-;XP_009242200.1,-;XP_009242203.1,-;XP_009242202.1,-","PF15168,Triple QxxK/R motif-containing protein family","IPR024842,Triple repetitive-sequence of QXXK/R protein","ENOG41121WQ,-;ENOG410J2GZ,-","GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["S100A8",5.192965404,0.97712757,2.369761121,1.946912452,4.23033E-3,0.008851735,"ENSG00000143546","H2Q028,Protein S100","XP_513814.2,-","PF01023,S-100/ICaBP type calcium binding domain","IPR018247,EF-Hand 1, calcium-binding site;IPR013787,S100/CaBP-9k-type, calcium binding, subdomain;IPR002048,EF-hand domain;IPR028474,Protein S100-A8;IPR001751,S100/Calbindin-D9k, conserved site;IPR011992,EF-hand domain pair","ENOG4111CN5,-;ENOG410J2UM,-","GO:0050544,molecular_function,arachidonic acid binding;GO:0070488,biological_process,neutrophil aggregation;GO:0005509,molecular_function,calcium ion binding;GO:0018119,biological_process,peptidyl-cysteine S-nitrosylation;GO:0008017,molecular_function,microtubule binding;GO:0002793,biological_process,positive regulation of peptide secretion;GO:0006919,biological_process,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:0030593,biological_process,neutrophil chemotaxis;GO:0002523,biological_process,leukocyte migration involved in inflammatory response;GO:0005829,cellular_component,cytosol;GO:0014002,biological_process,astrocyte development;GO:2001244,biological_process,positive regulation of intrinsic apoptotic signaling pathway;GO:0008270,molecular_function,zinc ion binding;GO:0050729,biological_process,positive regulation of inflammatory response;GO:0050727,biological_process,regulation of inflammatory response;GO:0045087,biological_process,innate immune response;GO:0006914,biological_process,autophagy;GO:0046872,molecular_function,metal ion binding;GO:0050786,molecular_function,RAGE receptor binding;GO:0045111,cellular_component,intermediate filament cytoskeleton;GO:0035662,molecular_function,Toll-like receptor 4 binding","-"]
["ZBTB45P1",3.587996701,0.675130725,2.369761121,1.946912452,4.23033E-3,0.008851735,"ENSG00000225108","H9ZEI3,Zinc finger and BTB domain-containing protein 45","XP_014980466.1,-;NP_001253625.1,zinc finger and BTB domain-containing protein 45;XP_014980464.1,-;XP_014980465.1,-","-","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["TBX1",1.494314415,0.281175725,2.369761121,1.946912452,4.23033E-3,0.008851735,"ENSG00000184058","D9ZGG0,T-box 1","XP_006724375.1,-;XP_016884415.1,-;NP_542378.1,T-box transcription factor TBX1 isoform C","PF00907,T-box","IPR001699,Transcription factor, T-box;IPR036960,T-box superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR018186,Transcription factor, T-box, conserved site","KOG3586,TBX1 and related T-box transcription factors;ENOG410Y98J,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0006351,biological_process,transcription, DNA-templated","-"]
["BEND3",0.763872378,0.143733051,2.369761121,1.946912452,4.23033E-3,0.008851735,"ENSG00000178409","H2QTH7,Uncharacterized protein","XP_009450047.1,BEN domain-containing protein 3","PF10523,BEN domain","IPR033583,BEN domain-containing protein 3;IPR018379,BEN domain","ENOG410Y8FH,-;ENOG410IHA7,-","GO:0043967,biological_process,histone H4 acetylation;GO:0003677,molecular_function,DNA binding;GO:0034773,biological_process,histone H4-K20 trimethylation;GO:0005730,cellular_component,nucleolus;GO:0000183,biological_process,chromatin silencing at rDNA;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0098532,biological_process,histone H3-K27 trimethylation;GO:0006306,biological_process,DNA methylation;GO:0051260,biological_process,protein homooligomerization;GO:0000182,molecular_function,rDNA binding;GO:0005720,cellular_component,nuclear heterochromatin;GO:1903580,biological_process,positive regulation of ATP metabolic process;GO:0036124,biological_process,histone H3-K9 trimethylation;GO:0080182,biological_process,histone H3-K4 trimethylation;GO:0005654,cellular_component,nucleoplasm","-"]
["BBS9",0.843280581,0.158674792,2.369761121,1.946912452,4.23033E-3,0.008851735,"ENSG00000122507","A0A090N8P4,Parathyroid hormone-responsive B1 protein","NP_001334965.1,-;NP_940820.1,protein PTHB1 isoform 2","PF14728,PTHB1 C-terminus;PF14727,PTHB1 N-terminus","IPR026511,Parathyroid hormone-responsive B1;IPR028074,PTHB1, C-terminal domain;IPR028073,PTHB1, N-terminal domain","KOG3679,Predicted coiled-coil protein;ENOG410XR64,-","GO:0034464,cellular_component,BBSome;GO:0045444,biological_process,fat cell differentiation;GO:0060271,biological_process,cilium assembly;GO:0016020,cellular_component,membrane","-"]
["ZNF81",0.618752007,0.116426665,2.369761121,1.946912452,4.23033E-3,0.008851735,"ENSG00000197779","H2PVH3,Zinc finger protein 81","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["SLFNL1-AS1",3.908198224,0.750895395,2.368752389,3.598986515,{"v":1.43E-7,"d":"1.43E-07"},{"v":8.12e-07,"d":"8.12E-07"},"ENSG00000281207","G3RLW3,Schlafen like 1","XP_018872036.1,-;XP_018872022.1,schlafen-like protein 1 isoform X1;XP_018872030.1,-","PF04326,Putative DNA-binding domain","IPR029667,Schlafen-like protein 1;IPR029684,Schlafen family;IPR007421,Schlafen, AAA domain;IPR038461,Schlafen, AAA domain superfamily","-","GO:0005524,molecular_function,ATP binding","-"]
["NETO1",5.862149167,1.130079045,2.368588378,4.340881194,1.96E-10,{"v":2.1e-09,"d":"2.10E-09"},"ENSG00000166342","A0A024R375,Neuropilin","XP_016881507.1,-;XP_016881506.1,neuropilin and tolloid-like protein 1 isoform X1;XP_005266831.1,-","PF00431,CUB domain;PF00057,Low-density lipoprotein receptor domain class A","IPR035914,Spermadhesin, CUB domain superfamily;IPR028867,Neuropilin and tolloid-like protein 1;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR000859,CUB domain;IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR036055,LDL receptor-like superfamily","ENOG410IJXA,-;ENOG410ZS19,-","GO:0098839,cellular_component,postsynaptic density membrane;GO:0008542,biological_process,visual learning;GO:0035255,molecular_function,ionotropic glutamate receptor binding;GO:0097120,biological_process,receptor localization to synapse;GO:0048168,biological_process,regulation of neuronal synaptic plasticity;GO:0007613,biological_process,memory;GO:0014069,cellular_component,postsynaptic density;GO:0060076,cellular_component,excitatory synapse;GO:2000463,biological_process,positive regulation of excitatory postsynaptic potential;GO:0016020,cellular_component,membrane;GO:0045202,cellular_component,synapse;GO:0048169,biological_process,regulation of long-term neuronal synaptic plasticity;GO:0016021,cellular_component,integral component of membrane","-"]
["ABLIM1",32.71662421,6.340159863,2.366793282,7.599196646,{"v":1.78e-23,"d":"1.78E-23"},{"v":2.56e-21,"d":"2.56E-21"},"ENSG00000099204","H2R0M2,Uncharacterized protein","XP_016774916.1,actin-binding LIM protein 1 isoform X35","PF02209,Villin headpiece domain;PF16182,Putative adherens-junction anchoring region of AbLIM;PF00412,LIM domain","IPR001781,Zinc finger, LIM-type;IPR028448,Actin-binding LIM protein 1;IPR003128,Villin headpiece;IPR036886,Villin headpiece domain superfamily;IPR032402,Putative adherens-junction anchoring domain","ENOG410XRPY,-;KOG1044,Actin-binding LIM Zn-finger protein Limatin involved in axon guidance","GO:0001725,cellular_component,stress fiber;GO:0007010,biological_process,cytoskeleton organization;GO:0030032,biological_process,lamellipodium assembly;GO:0046872,molecular_function,metal ion binding;GO:0030027,cellular_component,lamellipodium;GO:0003779,molecular_function,actin binding;GO:0060271,biological_process,cilium assembly","-"]
["PRR14",12.73426168,2.461720183,2.366770032,4.924828651,{"v":8.58e-13,"d":"8.58E-13"},{"v":1.59e-11,"d":"1.59E-11"},"ENSG00000156858","A0A024QZB5,Uncharacterized protein","NP_001307393.1,-;NP_076936.1,proline-rich protein 14","PF15386,rosophila Tantalus-like","IPR028149,Tantalus-like;IPR026320,Proline-rich protein 14","ENOG4111V15,-;ENOG410IJQ9,-","-","-"]
["KANSL1",4.739655398,0.917495287,2.365880832,5.338698451,{"v":9.49e-15,"d":"9.49E-15"},{"v":2.74e-13,"d":"2.74E-13"},"ENSG00000120071","A0A024R9Y2,KIAA1267, isoform CRA_a","XP_006721886.1,-;NP_001180395.1,-;NP_056258.1,KAT8 regulatory NSL complex subunit 1 isoform 1;XP_006721887.1,-","PF15275,PEHE domain","IPR029332,PEHE domain;IPR026180,KAT8 regulatory NSL complex subunit 1","ENOG410ZYQQ,-;ENOG410IKZN,-","GO:0000123,cellular_component,histone acetyltransferase complex;GO:0005654,cellular_component,nucleoplasm","-"]
["PLEKHA6",2.676499032,0.516255579,2.364825625,3.820570883,{"v":3.6e-08,"d":"3.60E-08"},{"v":2.35E-7,"d":"2.35E-07"},"ENSG00000143850","A0A1B0GUN5,Pleckstrin homology domain-containing family A member 6","-","PF00169,PH domain","IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","-","-","-"]
["GTF2IP4",6.119089363,1.180278411,2.364825625,3.820570883,{"v":3.6e-08,"d":"3.60E-08"},{"v":2.35E-7,"d":"2.35E-07"},"ENSG00000233369","K7B7I3,General transcription factor IIi","XP_016800730.1,-;XP_016800731.1,-;XP_003951092.1,-","PF02946,TF2I-like repeat","IPR016659,Transcription factor II-I;IPR004212,GTF2I-like repeat;IPR036647,GTF2I-like repeat superfamily","ENOG410IEPZ,-;ENOG41100H8,-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["IKBKB",6.934327907,1.344063355,2.364250272,5.441536032,{"v":2.3e-15,"d":"2.30E-15"},{"v":7.57e-14,"d":"7.57E-14"},"ENSG00000104365","K7CMD5,Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta","XP_016814903.1,inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3","PF00069,Protein kinase domain;PF12179,I-kappa-kinase-beta NEMO binding domain","IPR022007,I-kappa-kinase-beta NEMO binding domain;IPR000626,Ubiquitin domain;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR029071,Ubiquitin-like domain superfamily;IPR000719,Protein kinase domain","ENOG410XRMU,-;KOG4250,TANK binding protein kinase TBK1","GO:0016301,molecular_function,kinase activity;GO:0005524,molecular_function,ATP binding;GO:0008384,molecular_function,IkappaB kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0005622,cellular_component,intracellular;GO:0007252,biological_process,I-kappaB phosphorylation;GO:0006468,biological_process,protein phosphorylation;GO:0016310,biological_process,phosphorylation","-"]
["NUP58",5.354359446,1.037506591,2.363897904,5.102900344,{"v":7.9e-14,"d":"7.90E-14"},1.85E-12,"ENSG00000139496","H2Q7B2,Nucleoporin like 1","XP_001155721.1,nucleoporin p58/p45 isoform X2","PF15967,Nucleoporin FG repeated region","IPR024882,Nucleoporin p58/p45","ENOG410IIR3,-;ENOG410ZJAM,-","GO:0006606,biological_process,protein import into nucleus;GO:0008139,molecular_function,nuclear localization sequence binding;GO:0006913,biological_process,nucleocytoplasmic transport;GO:0005643,cellular_component,nuclear pore","-"]
["TBC1D2B",2.432245675,0.469864614,2.363276898,3.919635745,{"v":1.27E-8,"d":"1.27E-08"},{"v":9.13e-08,"d":"9.13E-08"},"ENSG00000167202","A0A096NMV0,TBC1 domain family member 2B","XP_009208965.2,TBC1 domain family member 2B isoform X1","PF00566,Rab-GTPase-TBC domain;PF00169,PH domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","-","GO:0005829,cellular_component,cytosol","-"]
["ZC3H12A",2.20928592,0.420485653,2.36324574,2.289193902,0.000758987,0.001881742,"ENSG00000163874","K7CMP2,Zinc finger CCCH-type containing 12A","XP_016814904.1,-;XP_016814910.1,-;XP_016814897.1,-","PF11977,Zc3h12a-like Ribonuclease NYN domain","IPR021869,Ribonuclease Zc3h12a-like, NYN domain","KOG3777,Uncharacterized conserved protein;ENOG410ZNK1,-","GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:2000379,biological_process,positive regulation of reactive oxygen species metabolic process;GO:0032991,cellular_component,protein-containing complex;GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0061158,biological_process,3'-UTR-mediated mRNA destabilization;GO:0045019,biological_process,negative regulation of nitric oxide biosynthetic process;GO:0035925,molecular_function,mRNA 3'-UTR AU-rich region binding;GO:0010656,biological_process,negative regulation of muscle cell apoptotic process;GO:1903936,biological_process,cellular response to sodium arsenite;GO:0005856,cellular_component,cytoskeleton;GO:0010595,biological_process,positive regulation of endothelial cell migration;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0032715,biological_process,negative regulation of interleukin-6 production;GO:1900745,biological_process,positive regulation of p38MAPK cascade;GO:0010628,biological_process,positive regulation of gene expression;GO:0035613,molecular_function,RNA stem-loop binding;GO:1903003,biological_process,positive regulation of protein deubiquitination;GO:0016579,biological_process,protein deubiquitination;GO:0002757,biological_process,immune response-activating signal transduction;GO:0050852,biological_process,T cell receptor signaling pathway;GO:0004532,molecular_function,exoribonuclease activity;GO:0045600,biological_process,positive regulation of fat cell differentiation;GO:1904637,biological_process,cellular response to ionomycin;GO:0071347,biological_process,cellular response to interleukin-1;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0005737,cellular_component,cytoplasm;GO:1900016,biological_process,negative regulation of cytokine production involved in inflammatory response;GO:0003730,molecular_function,mRNA 3'-UTR binding;GO:0005791,cellular_component,rough endoplasmic reticulum;GO:0005634,cellular_component,nucleus;GO:0032720,biological_process,negative regulation of tumor necrosis factor production;GO:0042406,cellular_component,extrinsic component of endoplasmic reticulum membrane;GO:0002230,biological_process,positive regulation of defense response to virus by host;GO:0004540,molecular_function,ribonuclease activity;GO:0000932,cellular_component,P-body;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0000294,biological_process,nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay;GO:0090501,biological_process,RNA phosphodiester bond hydrolysis;GO:0044828,biological_process,negative regulation by host of viral genome replication;GO:0010508,biological_process,positive regulation of autophagy;GO:0042347,-,-;GO:0042149,biological_process,cellular response to glucose starvation;GO:0003729,molecular_function,mRNA binding;GO:0010942,biological_process,positive regulation of cell death;GO:0003677,molecular_function,DNA binding;GO:0043124,biological_process,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0061014,biological_process,positive regulation of mRNA catabolic process;GO:0043022,molecular_function,ribosome binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0042307,biological_process,positive regulation of protein import into nucleus;GO:0051259,biological_process,protein complex oligomerization;GO:0090503,biological_process,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:1903799,biological_process,negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:0010629,biological_process,negative regulation of gene expression;GO:0010468,biological_process,regulation of gene expression;GO:1990869,biological_process,cellular response to chemokine;GO:0035198,molecular_function,miRNA binding;GO:0034599,biological_process,cellular response to oxidative stress;GO:0005654,cellular_component,nucleoplasm;GO:1904468,biological_process,negative regulation of tumor necrosis factor secretion;GO:1902714,biological_process,negative regulation of interferon-gamma secretion;GO:0098586,biological_process,cellular response to virus;GO:2000627,biological_process,positive regulation of miRNA catabolic process;GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:1900165,biological_process,negative regulation of interleukin-6 secretion;GO:0010884,biological_process,positive regulation of lipid storage;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0003723,molecular_function,RNA binding;GO:1900119,biological_process,positive regulation of execution phase of apoptosis;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0050713,biological_process,negative regulation of interleukin-1 beta secretion;GO:0003682,molecular_function,chromatin binding;GO:0055118,biological_process,negative regulation of cardiac muscle contraction;GO:0004521,molecular_function,endoribonuclease activity","-"]
["OCEL1",3.688454319,0.702010595,2.36324574,2.289193902,0.000758987,0.001881742,"ENSG00000099330","H2QFQ3,Occludin/ELL domain containing 1","XP_512479.2,occludin/ELL domain-containing protein 1 isoform X1","PF07303,Occludin homology domain","IPR031176,ELL/occludin family;IPR010844,Occludin homology domain;IPR031182,Occludin/ELL domain-containing protein 1","KOG4796,RNA polymerase II elongation factor;ENOG410ZNGU,-","-","-"]
["TTN-AS1",0.333414555,0.063457625,2.36324574,2.289193902,0.000758987,0.001881742,"ENSG00000237298","G1R2Q9,Uncharacterized protein","-","PF00069,Protein kinase domain;PF00041,ibronectin type III domain;PF07679,Immunoglobulin I-set domain","-","-","-","-"]
["PTCHD4",1.330180455,0.253168588,2.36324574,2.289193902,0.000758987,0.001881742,"ENSG00000244694","H2QT51,Uncharacterized protein","XP_527402.3,patched domain-containing protein 4 isoform X3","PF02460,Patched family","IPR000731,Sterol-sensing domain;IPR003392,Protein patched/dispatched","ENOG410XRZ4,-;KOG1934,Predicted membrane protein (patched superfamily)","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SMAP1",14.20994381,2.756121264,2.362705607,5.184289546,{"v":4.9e-14,"d":"4.90E-14"},1.19E-12,"ENSG00000112305","K7BIY4,Small ArfGAP 1","XP_016811276.1,stromal membrane-associated protein 1 isoform X1","PF01412,Putative GTPase activating protein for Arf","IPR001164,Arf GTPase activating protein;IPR038508,ArfGAP domain superfamily;IPR037278,ARFGAP/RecO-like zinc finger","COG5347,GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport;KOG0703,Predicted GTPase-activating protein","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0046872,molecular_function,metal ion binding;GO:0005096,molecular_function,GTPase activator activity","K12486,ko04144,Endocytosis"]
["ZCCHC14",5.719608371,1.108469029,2.362472886,4.714906438,{"v":7.93e-12,"d":"7.93E-12"},1.16E-10,"ENSG00000140948","A8K0W7,cDNA FLJ75992, highly similar to Homo sapiens zinc finger, CCHC domain containing 14","-","PF00098,Zinc knuckle","IPR036871,PX domain superfamily;IPR001878,Zinc finger, CCHC-type;IPR037632,ZCCH14, SAM domain;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR036875,Zinc finger, CCHC-type superfamily","KOG3791,Predicted RNA-binding protein involved in translational regulation;ENOG410ZTU4,-;KOG4400,E3 ubiquitin ligase interacting with arginine methyltransferase","GO:0003676,molecular_function,nucleic acid binding;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0008270,molecular_function,zinc ion binding","-"]
["ZBTB2",8.760665554,1.696639198,2.360752869,4.099228629,{"v":3.86e-09,"d":"3.86E-09"},{"v":3.11e-08,"d":"3.11E-08"},"ENSG00000181472","H2PKM6,Zinc finger and BTB domain containing 2","XP_002817536.1,-","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II","-"]
["SH3BP4",9.226604046,1.792519899,2.36068464,5.334424635,{"v":1.14e-14,"d":"1.14E-14"},{"v":3.22e-13,"d":"3.22E-13"},"ENSG00000130147","A8K594,cDNA FLJ77256, highly similar to Homo sapiens SH3-domain binding protein 4","-","PF07653,Variant SH3 domain;PF14604,Variant SH3 domain;PF00791,ZU5 domain","IPR035455,SH3 domain-binding protein 4;IPR001452,SH3 domain;IPR035456,SH3BP4, SH3 domain;IPR000906,ZU5 domain;IPR036028,SH3-like domain superfamily","ENOG41118AI,-;ENOG410IEE9,-","GO:0032007,biological_process,negative regulation of TOR signaling;GO:0017016,molecular_function,Ras GTPase binding","-"]
["SNX9",14.9020708,2.897175167,2.35982079,5.403995876,{"v":4.34e-15,"d":"4.34E-15"},{"v":1.35e-13,"d":"1.35E-13"},"ENSG00000130340","H2R1Q2,Sorting nexin","XP_001144722.1,-","PF00018,SH3 domain;PF00787,PX domain;PF10456,WASP-binding domain of Sorting nexin protein","IPR037425,Sorting nexin-9, BAR domain;IPR014536,Sorting nexin 9 family;IPR037426,Sorting nexin-9, PX domain;IPR036871,PX domain superfamily;IPR035558,SNX9, SH3 domain;IPR028644,Sorting nexin-9;IPR027267,AH/BAR domain superfamily;IPR001683,Phox homologous domain;IPR001452,SH3 domain;IPR036028,SH3-like domain superfamily;IPR019497,Sorting nexin protein, WASP-binding domain","KOG2528,Sorting nexin SNX9/SH3PX1 and related proteins;ENOG410XPHZ,-","GO:0031410,cellular_component,cytoplasmic vesicle;GO:0015031,biological_process,protein transport;GO:0000281,biological_process,mitotic cytokinesis;GO:0000278,biological_process,mitotic cell cycle;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0030659,cellular_component,cytoplasmic vesicle membrane;GO:0016020,cellular_component,membrane;GO:0006897,biological_process,endocytosis;GO:0006886,biological_process,intracellular protein transport","-"]
["HOXC13",3.528091304,0.676152384,2.359268446,2.564049207,0.000382556,0.001017768,"ENSG00000123364","H2Q629,Uncharacterized protein","XP_522408.2,-","PF12284,Hox protein A13 N terminal;PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR022067,Homeobox protein Hox1A3 N-terminal;IPR009057,Homeobox-like domain superfamily","KOG0487,Transcription factor Abd-B, contains HOX domain;ENOG4111FJP,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0009653,biological_process,anatomical structure morphogenesis;GO:0003677,molecular_function,DNA binding;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0043587,biological_process,tongue morphogenesis;GO:0035878,biological_process,nail development;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0001942,biological_process,hair follicle development;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["CTD-2267D19.1",3.431780502,0.657694591,2.359268446,2.564049207,0.000382556,0.001017768,"ENSG00000278918","H2NU80,Uncharacterized protein","-","-","-","-","-","-"]
["ZNF324",1.509280584,0.289250923,2.359268446,2.564049207,0.000382556,0.001017768,"ENSG00000083812","A0A024R4R8,Zinc finger protein 324, isoform CRA_a","NP_055162.1,zinc finger protein 324A","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["NPTXR",1.477967709,0.283249866,2.359268446,2.564049207,0.000382556,0.001017768,"ENSG00000221890","A0A1X7SBT7,Neuronal pentraxin receptor","-","-","IPR001759,Pentraxin-related;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily","-","-","-"]
["EIF5A2",1.528440055,0.292922801,2.359268446,2.564049207,0.000382556,0.001017768,"ENSG00000163577","A0A091DFG0,Eukaryotic translation initiation factor 5A","XP_010630693.1,-;XP_010630692.1,-","PF01287,ukaryotic elongation factor 5A hypusine, DNA-binding OB fold","IPR019769,Translation elongation factor, IF5A, hypusine site;IPR001884,Translation elongation factor IF5A-like;IPR008991,Translation protein SH3-like domain superfamily;IPR020189,Translation elongation factor, IF5A C-terminal;IPR014722,Ribosomal protein L2, domain 2;IPR012340,Nucleic acid-binding, OB-fold","-","GO:0003723,molecular_function,RNA binding;GO:0003746,molecular_function,translation elongation factor activity;GO:0045901,biological_process,positive regulation of translational elongation;GO:0045905,biological_process,positive regulation of translational termination;GO:0043022,molecular_function,ribosome binding;GO:0006452,biological_process,translational frameshifting;GO:0006413,biological_process,translational initiation;GO:0003743,molecular_function,translation initiation factor activity;GO:0006412,biological_process,translation","-"]
["RP11-489E7.4",12.04023272,2.30748905,2.359268446,2.564049207,0.000382556,0.001017768,"ENSG00000272256","E5RK07,Store-operated calcium entry-associated regulatory factor","-","-","-","-","-","-"]
["IMPA1",2.298001406,0.440407856,2.359268446,2.564049207,0.000382556,0.001017768,"ENSG00000133731","A0A140VJL8,Inositol-1-monophosphatase","NP_001138350.1,inositol monophosphatase 1 isoform 2","PF00459,Inositol monophosphatase family","IPR033942,Inositol monophosphatase;IPR020550,Inositol monophosphatase, conserved site;IPR000760,Inositol monophosphatase-like;IPR020552,Inositol monophosphatase, Lithium-sensitive;IPR020583,Inositol monophosphatase, metal-binding site","-","GO:0016787,molecular_function,hydrolase activity;GO:0052832,molecular_function,inositol monophosphate 3-phosphatase activity;GO:0046872,molecular_function,metal ion binding;GO:0052833,molecular_function,inositol monophosphate 4-phosphatase activity;GO:0008934,molecular_function,inositol monophosphate 1-phosphatase activity;GO:0052834,molecular_function,inositol monophosphate phosphatase activity;GO:0046855,biological_process,inositol phosphate dephosphorylation;GO:0046854,biological_process,phosphatidylinositol phosphorylation;GO:0006021,biological_process,inositol biosynthetic process","-"]
["RPRD2",25.21893051,4.912326769,2.359097564,7.052809086,{"v":9.3e-22,"d":"9.30E-22"},1.03E-19,"ENSG00000163125","K7C3G9,Regulation of nuclear pre-mRNA domain containing 2","XP_016781905.1,regulation of nuclear pre-mRNA domain-containing protein 2 isoform X1","PF04818,RNA polymerase II-binding domain.;PF16566,Cell-cycle alteration and expression-elevated protein in tumour","IPR006903,RNA polymerase II-binding domain;IPR032337,Cell-cycle alteration and expression-elevated protein in tumour;IPR008942,ENTH/VHS;IPR006569,CID domain","ENOG410XRAP,-;KOG2669,Regulator of nuclear mRNA","GO:0016591,cellular_component,DNA-directed RNA polymerase II, holoenzyme","-"]
["MED12",10.20199143,1.985839061,2.358321688,5.533791717,1.26E-15,{"v":4.5e-14,"d":"4.50E-14"},"ENSG00000184634","H2PVY6,Mediator complex subunit 12","XP_009233233.1,mediator of RNA polymerase II transcription subunit 12 isoform X2","PF09497,Transcription mediator complex subunit Med12;PF12145,ukaryotic Mediator 12 subunit domain;PF12144,ukaryotic Mediator 12 catenin-binding domain","IPR019035,Mediator complex, subunit Med12;IPR021989,Mediator complex, subunit Med12, catenin-binding;IPR021990,Mediator complex, subunit Med12, LCEWAV-domain","ENOG410ISJR,-;ENOG41119EY,-","GO:0019827,biological_process,stem cell population maintenance;GO:0003712,molecular_function,transcription cofactor activity;GO:0016592,cellular_component,mediator complex;GO:0048702,biological_process,embryonic neurocranium morphogenesis;GO:1990403,biological_process,embryonic brain development;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component,nucleus;GO:0030178,biological_process,negative regulation of Wnt signaling pathway;GO:0007507,biological_process,heart development;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000980,molecular_function,RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0008013,molecular_function,beta-catenin binding;GO:0090245,biological_process,axis elongation involved in somitogenesis;GO:0021510,biological_process,spinal cord development;GO:0001843,biological_process,neural tube closure;GO:0003682,molecular_function,chromatin binding;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0001190,molecular_function,transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0046966,molecular_function,thyroid hormone receptor binding;GO:0007492,biological_process,endoderm development;GO:0006367,biological_process,transcription initiation from RNA polymerase II promoter;GO:0060071,biological_process,Wnt signaling pathway, planar cell polarity pathway;GO:0021915,biological_process,neural tube development;GO:0004872,-,-;GO:0001756,biological_process,somitogenesis;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0030521,biological_process,androgen receptor signaling pathway;GO:0003713,molecular_function,transcription coactivator activity;GO:0048568,biological_process,embryonic organ development;GO:0019904,molecular_function,protein domain specific binding;GO:0014003,biological_process,oligodendrocyte development;GO:0036342,biological_process,post-anal tail morphogenesis;GO:0030518,biological_process,intracellular steroid hormone receptor signaling pathway;GO:0008134,molecular_function,transcription factor binding;GO:0014044,biological_process,Schwann cell development;GO:0008022,molecular_function,protein C-terminus binding","-"]
["LIN54",7.964458183,1.549236147,2.358211853,5.055214586,1.72E-13,{"v":3.72e-12,"d":"3.72E-12"},"ENSG00000189308","G8F411,CXC domain-containing protein 1","XP_005554971.1,-;XP_005554970.1,-","PF03638,Tesmin/TSO1-like CXC domain, cysteine-rich domain","IPR005172,CRC domain;IPR028307,Lin-54 family;IPR033467,Tesmin/TSO1-like CXC domain","-","-","-"]
["EYA4",11.62410836,2.265291436,2.357385444,5.985934997,{"v":1.14e-17,"d":"1.14E-17"},{"v":6.05e-16,"d":"6.05E-16"},"ENSG00000112319","F2Z2Y1,Eyes absent homolog","NP_001287942.1,eyes absent homolog 4 isoform f","PF00702,haloacid dehalogenase-like hydrolase","IPR028472,Eyes absent family;IPR028478,Eyes absent homologue 4;IPR006545,EYA domain;IPR038102,EYA domain superfamily","KOG3107,Predicted haloacid dehalogenase-like hydrolase (eyes absent);ENOG410XT12,-","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0007605,biological_process,sensory perception of sound;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006470,biological_process,protein dephosphorylation;GO:0048839,biological_process,inner ear development;GO:0008134,molecular_function,transcription factor binding;GO:0007275,biological_process,multicellular organism development","-"]
["CREG2",4.715991697,0.916541105,2.357203854,4.402194209,2.32E-10,{"v":2.46e-09,"d":"2.46E-09"},"ENSG00000175874","H2QIG0,Cellular repressor of E1A-stimulated genes 2","XP_515663.4,protein CREG2","PF13883,Pyridoxamine 5'-phosphate oxidase","IPR014631,Cellular repressor of E1A-stimulated genes (CREG);IPR012349,FMN-binding split barrel","KOG3374,Cellular repressor of transcription;ENOG4111WS9,-","GO:0005794,cellular_component,Golgi apparatus;GO:0048037,molecular_function,cofactor binding;GO:0005783,cellular_component,endoplasmic reticulum","-"]
["ZNF658",2.108359745,0.405942736,2.356587925,2.793803698,{"v":5.65e-05,"d":"5.65E-05"},0.000180914,"ENSG00000274349","A0A087WVA2,Zinc finger protein 658","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TEX10",5.330671213,1.037909274,2.355345029,4.593572381,{"v":2.16e-11,"d":"2.16E-11"},{"v":2.88e-10,"d":"2.88E-10"},"ENSG00000136891","A0A024R169,Testis expressed sequence 10, isoform CRA_a","NP_060216.2,testis-expressed protein 10 isoform 1","PF12333,Rix1 complex component involved in 60S ribosome maturation","IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR021133,HEAT, type 2;IPR037947,Testis-expressed protein 10/pre-rRNA-processing protein Ipi1;IPR024679,Pre-rRNA-processing protein Ipi1, N-terminal","ENOG410YR7T,-;KOG2149,Uncharacterized conserved protein","-","-"]
["KLF4",26.15371373,5.104349923,2.355079137,5.864944673,{"v":3.61e-17,"d":"3.61E-17"},{"v":1.74e-15,"d":"1.74E-15"},"ENSG00000136826","H2QXN2,Kruppel like factor 4","XP_016816881.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0019827,biological_process,stem cell population maintenance;GO:0001010,molecular_function,transcription factor activity, sequence-specific DNA binding transcription factor recruiting;GO:0000790,cellular_component,nuclear chromatin;GO:0003676,molecular_function,nucleic acid binding;GO:0008013,molecular_function,beta-catenin binding;GO:2000134,biological_process,negative regulation of G1/S transition of mitotic cell cycle;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0030154,biological_process,cell differentiation;GO:0071499,biological_process,cellular response to laminar fluid shear stress;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0043433,biological_process,negative regulation of DNA binding transcription factor activity;GO:0010033,biological_process,response to organic substance;GO:0005634,cellular_component,nucleus;GO:0030336,biological_process,negative regulation of cell migration;GO:0048730,biological_process,epidermis morphogenesis;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0046985,biological_process,positive regulation of hemoglobin biosynthetic process;GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0005737,cellular_component,cytoplasm;GO:0034115,biological_process,negative regulation of heterotypic cell-cell adhesion;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0010629,biological_process,negative regulation of gene expression;GO:0048679,biological_process,regulation of axon regeneration;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0001047,molecular_function,core promoter binding;GO:0045444,biological_process,fat cell differentiation;GO:0042127,biological_process,regulation of cell proliferation;GO:0060761,biological_process,negative regulation of response to cytokine stimulus;GO:0010628,biological_process,positive regulation of gene expression;GO:0035166,biological_process,post-embryonic hemopoiesis;GO:0005719,cellular_component,nuclear euchromatin;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045595,biological_process,regulation of cell differentiation;GO:1904798,biological_process,positive regulation of core promoter binding;GO:0001190,molecular_function,transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0001085,molecular_function,RNA polymerase II transcription factor binding;GO:0051247,biological_process,positive regulation of protein metabolic process;GO:0045429,biological_process,positive regulation of nitric oxide biosynthetic process;GO:0031077,biological_process,post-embryonic camera-type eye development;GO:2000342,biological_process,negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0090051,biological_process,negative regulation of cell migration involved in sprouting angiogenesis;GO:0005654,cellular_component,nucleoplasm;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0045415,biological_process,negative regulation of interleukin-8 biosynthetic process;GO:0032270,biological_process,positive regulation of cellular protein metabolic process;GO:0061614,biological_process,pri-miRNA transcription by RNA polymerase II;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0000987,molecular_function,proximal promoter sequence-specific DNA binding;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0071363,biological_process,cellular response to growth factor stimulus;GO:0032526,biological_process,response to retinoic acid;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1903672,biological_process,positive regulation of sprouting angiogenesis;GO:0044798,cellular_component,nuclear transcription factor complex;GO:0051973,biological_process,positive regulation of telomerase activity;GO:0008134,molecular_function,transcription factor binding;GO:1904998,biological_process,negative regulation of leukocyte adhesion to arterial endothelial cell;GO:0009913,biological_process,epidermal cell differentiation","-"]
["TMEM55B",3.12201085,0.603114414,2.354658865,2.99125517,{"v":1.35e-05,"d":"1.35E-05"},{"v":4.98e-05,"d":"4.98E-05"},"ENSG00000165782","H9G1L2,Transmembrane protein 55B isoform 1","XP_002805012.1,-","PF09788,Transmembrane protein 55A","IPR019178,Phosphatidylinositol 4,5-bisphosphate 4-phosphatase","KOG4684,Uncharacterized conserved protein, contains C4-type Zn-finger;ENOG410XSVD,-","GO:0016787,molecular_function,hydrolase activity;GO:0034597,molecular_function,phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity;GO:0005768,cellular_component,endosome;GO:0005764,cellular_component,lysosome;GO:0046856,biological_process,phosphatidylinositol dephosphorylation;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0031902,cellular_component,late endosome membrane;GO:0005765,cellular_component,lysosomal membrane","-"]
["FHDC1",1.800850488,0.347890811,2.354658865,2.99125517,{"v":1.35e-05,"d":"1.35E-05"},{"v":4.98e-05,"d":"4.98E-05"},"ENSG00000137460","G3QU95,FH2 domain containing 1","-","PF02181,ormin Homology 2 Domain","IPR015425,Formin, FH2 domain","-","-","-"]
["C8orf37",3.561189941,0.687955644,2.354658865,2.99125517,{"v":1.35e-05,"d":"1.35E-05"},{"v":4.98e-05,"d":"4.98E-05"},"ENSG00000156172","H2QWG3,Chromosome 8 open reading frame 37","-","PF14996,Retinal Maintenance","IPR029239,C8orf37 protein","ENOG4112BQE,-;ENOG410IVWJ,-","GO:0005737,cellular_component,cytoplasm;GO:0005829,cellular_component,cytosol;GO:0030054,cellular_component,cell junction;GO:0097546,cellular_component,ciliary base;GO:0005886,cellular_component,plasma membrane","-"]
["TMCC1",9.232367843,1.801960371,2.354300991,5.466459292,{"v":2.06e-15,"d":"2.06E-15"},{"v":6.89e-14,"d":"6.89E-14"},"ENSG00000172765","H2QNC8,Transmembrane and coiled-coil domain family 1","-","PF10267,Predicted transmembrane and coiled-coil 2 protein","IPR019394,Testis-specific protein TEX28/transmembrane and coiled-coil domains protein","ENOG410Y9KV,-;KOG3850,Predicted membrane protein","-","-"]
["CDK13",5.08405871,0.991695215,2.353504305,4.814493402,2.51E-12,{"v":4.11e-11,"d":"4.11E-11"},"ENSG00000065883","A0A024RA85,Cell division cycle 2-like 5","NP_003709.3,cyclin-dependent kinase 13 isoform 1","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XPIR,-;KOG0600,Cdc2-related protein kinase","GO:0030332,molecular_function,cyclin binding;GO:0000380,biological_process,alternative mRNA splicing, via spliceosome;GO:0019901,molecular_function,protein kinase binding;GO:0051301,biological_process,cell division;GO:0005794,cellular_component,Golgi apparatus;GO:2000737,biological_process,negative regulation of stem cell differentiation;GO:0004672,molecular_function,protein kinase activity;GO:0016607,cellular_component,nuclear speck;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0019908,cellular_component,nuclear cyclin-dependent protein kinase holoenzyme complex","-"]
["AC110615.1",11.98868758,2.321795891,2.353204114,3.164422617,{"v":3.45E-6,"d":"3.45E-06"},{"v":1.45E-5,"d":"1.45E-05"},"ENSG00000279909","Q9H359,PRO1405","-","-","-","ENOG410JG5M,-;ENOG41119H1,-","-","-"]
["ZFPM1",2.487307577,0.482646646,2.352067892,3.318663248,{"v":2.28e-06,"d":"2.28E-06"},{"v":1e-05,"d":"1.00E-05"},"ENSG00000179588","A0A0D9S248,Zinc finger protein, FOG family member 1","-","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type","IPR013087,Zinc finger C2H2-type;IPR034731,Zinc finger CCHC FOG-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0060377,biological_process,negative regulation of mast cell differentiation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030219,biological_process,megakaryocyte differentiation;GO:0071733,biological_process,transcriptional activation by promoter-enhancer looping;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0030218,biological_process,erythrocyte differentiation;GO:0005634,cellular_component,nucleus;GO:0007507,biological_process,heart development;GO:0003192,biological_process,mitral valve formation;GO:0005737,cellular_component,cytoplasm;GO:0032642,biological_process,regulation of chemokine production;GO:0045078,biological_process,positive regulation of interferon-gamma biosynthetic process;GO:0045599,biological_process,negative regulation of fat cell differentiation;GO:0048872,biological_process,homeostasis of number of cells;GO:0045403,biological_process,negative regulation of interleukin-4 biosynthetic process;GO:0003181,biological_process,atrioventricular valve morphogenesis;GO:0060318,biological_process,definitive erythrocyte differentiation;GO:0035162,biological_process,embryonic hemopoiesis;GO:0060413,biological_process,atrial septum morphogenesis;GO:0035855,biological_process,megakaryocyte development;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0001085,molecular_function,RNA polymerase II transcription factor binding;GO:0010724,biological_process,regulation of definitive erythrocyte differentiation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001102,molecular_function,RNA polymerase II activating transcription factor binding;GO:0055008,biological_process,cardiac muscle tissue morphogenesis;GO:0003151,biological_process,outflow tract morphogenesis;GO:0005667,cellular_component,transcription factor complex;GO:0017053,cellular_component,transcriptional repressor complex;GO:0060319,biological_process,primitive erythrocyte differentiation;GO:0030220,biological_process,platelet formation;GO:0032091,biological_process,negative regulation of protein binding;GO:0060412,biological_process,ventricular septum morphogenesis;GO:0003195,biological_process,tricuspid valve formation;GO:0030851,biological_process,granulocyte differentiation","-"]
["MEIS3",2.967092795,0.575745999,2.352067892,3.318663248,{"v":2.28e-06,"d":"2.28E-06"},{"v":1e-05,"d":"1.00E-05"},"ENSG00000105419","H0YNA8,Homeobox protein Meis3","XP_016882500.1,homeobox protein Meis3 isoform X1","PF16493,N-terminal of Homeobox Meis and PKNOX1;PF05920,Homeobox KN domain","IPR008422,Homeobox KN domain;IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR032453,Homeobox protein PKNOX/Meis, N-terminal","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["C2CD3",4.401257963,0.860145866,2.351574736,5.092798618,1.18E-13,{"v":2.64e-12,"d":"2.64E-12"},"ENSG00000168014","G1S5D1,C2 calcium dependent domain containing 3","-","PF00168,C2 domain","IPR000008,C2 domain;IPR037775,C2CD3, C2 domain;IPR035892,C2 domain superfamily","ENOG410XNN4,-;ENOG410IDYN,-","GO:0001947,biological_process,heart looping;GO:0071539,biological_process,protein localization to centrosome;GO:0034451,cellular_component,centriolar satellite;GO:0042733,biological_process,embryonic digit morphogenesis;GO:0061511,biological_process,centriole elongation;GO:0001701,biological_process,in utero embryonic development;GO:0030162,biological_process,regulation of proteolysis;GO:0016485,biological_process,protein processing;GO:0005814,cellular_component,centriole;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0021997,biological_process,neural plate axis specification;GO:1905515,biological_process,non-motile cilium assembly;GO:0008589,biological_process,regulation of smoothened signaling pathway;GO:0036064,cellular_component,ciliary basal body;GO:0005813,cellular_component,centrosome;GO:0007420,biological_process,brain development;GO:0007389,biological_process,pattern specification process;GO:0021915,biological_process,neural tube development;GO:0060271,biological_process,cilium assembly","-"]
["SIPA1L3",5.353479811,1.046240318,2.351574736,5.092798618,1.18E-13,{"v":2.64e-12,"d":"2.64E-12"},"ENSG00000105738","B2RWP0,Signal-induced proliferation-associated 1 like 3","NP_055888.1,signal-induced proliferation-associated 1-like protein 3","PF02145,Rap/ran-GAP;PF11881,C-terminal domain of SPAR protein","IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR035974,Rap/Ran-GAP superfamily;IPR000331,Rap GTPase activating protein domain;IPR021818,Signal-induced proliferation-associated 1-like protein, C-terminal;IPR031204,Signal-induced proliferation-associated 1-like protein 3","ENOG410XTIX,-;KOG3686,Rap1-GTPase-activating protein (Rap1GAP)","GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity","K17703,ko04015,Rap1 signaling pathway"]
["USF3",8.763451278,1.717263652,2.349696654,6.191741922,{"v":1.97e-18,"d":"1.97E-18"},1.23E-16,"ENSG00000176542","G3QFC1,Upstream transcription factor family member 3","XP_004036122.1,basic helix-loop-helix domain-containing protein USF3","PF00010,Helix-loop-helix DNA-binding domain","IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","-","GO:0046983,molecular_function,protein dimerization activity;GO:0010719,biological_process,negative regulation of epithelial to mesenchymal transition","-"]
["KYAT3",9.473691833,1.847192015,2.349253174,3.80809412,{"v":4.92e-08,"d":"4.92E-08"},{"v":3.1E-7,"d":"3.10E-07"},"ENSG00000137944","B4DW13,HCG23341, isoform CRA_d","NP_001008661.1,kynurenine--oxoglutarate transaminase 3 isoform 1","PF00155,Aminotransferase class I and II","IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR004839,Aminotransferase, class I/classII;IPR015424,Pyridoxal phosphate-dependent transferase;IPR015422,Pyridoxal phosphate-dependent transferase domain 1;IPR034612,Kynurenine--oxoglutarate transaminase 3","COG0436,Aspartate/tyrosine/aromatic aminotransferase;KOG0257,Kynurenine aminotransferase, glutamine transaminase K","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0006520,biological_process,cellular amino acid metabolic process;GO:0006103,biological_process,2-oxoglutarate metabolic process;GO:0042803,molecular_function,protein homodimerization activity;GO:0097052,biological_process,L-kynurenine metabolic process;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0016212,molecular_function,kynurenine-oxoglutarate transaminase activity;GO:0070189,biological_process,kynurenine metabolic process;GO:0005739,cellular_component,mitochondrion;GO:0009058,biological_process,biosynthetic process;GO:0047315,molecular_function,kynurenine-glyoxylate transaminase activity;GO:0008483,molecular_function,transaminase activity;GO:0036137,molecular_function,kynurenine aminotransferase activity","K00816,ko05204,Chemical carcinogenesis;K00816,ko00380,Tryptophan metabolism;K00816,ko00450,Selenocompound metabolism"]
["TIMM9",14.56422224,2.839749857,2.349253174,3.80809412,{"v":4.92e-08,"d":"4.92E-08"},{"v":3.1E-7,"d":"3.10E-07"},"ENSG00000100575","G1RS78,Translocase of inner mitochondrial membrane 9","-","PF02953,Tim10/DDP family zinc finger","-","-","-","-"]
["ZNF595",6.399892042,1.24966989,2.348403765,4.001372017,{"v":6.25e-09,"d":"6.25E-09"},{"v":4.81e-08,"d":"4.81E-08"},"ENSG00000272602","Q7Z3I0,Uncharacterized protein DKFZp313E1411","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TLE1",6.824680083,1.335766185,2.34701852,4.393936753,{"v":1.44e-10,"d":"1.44E-10"},{"v":1.58e-09,"d":"1.58E-09"},"ENSG00000196781","K7BFR8,Transducin-like enhancer of split 1","XP_016816499.1,-","PF00400,WD domain, G-beta repeat;PF03920,roucho/TLE N-terminal Q-rich domain","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR009146,Groucho/transducin-like enhancer;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR005617,Groucho/TLE, N-terminal Q-rich domain","ENOG410XPX3,-;KOG0639,Transducin-like enhancer of split protein (contains WD40 repeats)","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["FOXC1",15.3024495,3.004555278,2.345161919,5.209372024,{"v":5.08e-14,"d":"5.08E-14"},1.23E-12,"ENSG00000054598","W6CJ52,Forkhead box C1","NP_001444.2,forkhead box protein C1","PF00250,orkhead domain","IPR018122,Fork head domain conserved site1;IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily","KOG2294,Transcription factor of the Forkhead/HNF3 family;COG5025,Transcription factor of the Forkhead/HNF3 family","GO:0001541,biological_process,ovarian follicle development;GO:0003705,molecular_function,transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0060038,biological_process,cardiac muscle cell proliferation;GO:0001756,biological_process,somitogenesis;GO:0014031,biological_process,mesenchymal cell development;GO:0030199,biological_process,collagen fibril organization;GO:0003007,biological_process,heart morphogenesis;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0055010,biological_process,ventricular cardiac muscle tissue morphogenesis;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0030203,biological_process,glycosaminoglycan metabolic process;GO:0003677,molecular_function,DNA binding;GO:0008354,biological_process,germ cell migration;GO:0005634,cellular_component,nucleus;GO:0035050,biological_process,embryonic heart tube development;GO:0014032,biological_process,neural crest cell development;GO:0007507,biological_process,heart development;GO:0001501,biological_process,skeletal system development;GO:0048341,biological_process,paraxial mesoderm formation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:1902257,biological_process,negative regulation of apoptotic process involved in outflow tract morphogenesis;GO:0001657,biological_process,ureteric bud development;GO:0036438,biological_process,maintenance of lens transparency;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0001654,biological_process,eye development;GO:0070098,biological_process,chemokine-mediated signaling pathway;GO:0001945,biological_process,lymph vessel development;GO:0001974,biological_process,blood vessel remodeling;GO:0005829,cellular_component,cytosol;GO:0001822,biological_process,kidney development;GO:1901491,biological_process,negative regulation of lymphangiogenesis;GO:0001958,biological_process,endochondral ossification;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0001223,molecular_function,transcription coactivator binding;GO:0010628,biological_process,positive regulation of gene expression;GO:0046620,biological_process,regulation of organ growth;GO:0043565,molecular_function,sequence-specific DNA binding;GO:1902038,biological_process,positive regulation of hematopoietic stem cell differentiation;GO:1904798,biological_process,positive regulation of core promoter binding;GO:0038084,biological_process,vascular endothelial growth factor signaling pathway;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0007420,biological_process,brain development;GO:1990869,biological_process,cellular response to chemokine;GO:0072010,biological_process,glomerular epithelium development;GO:0048762,biological_process,mesenchymal cell differentiation;GO:0005654,cellular_component,nucleoplasm;GO:0021549,biological_process,cerebellum development;GO:0001503,biological_process,ossification;GO:0050880,biological_process,regulation of blood vessel size;GO:0032808,biological_process,lacrimal gland development;GO:0043010,biological_process,camera-type eye development;GO:0003713,molecular_function,transcription coactivator activity;GO:0048010,biological_process,vascular endothelial growth factor receptor signaling pathway;GO:0048844,biological_process,artery morphogenesis;GO:0001701,biological_process,in utero embryonic development;GO:0007219,biological_process,Notch signaling pathway;GO:0001568,biological_process,blood vessel development;GO:0008134,molecular_function,transcription factor binding;GO:1901534,biological_process,positive regulation of hematopoietic progenitor cell differentiation","-"]
["VPS54",12.78021603,2.510091212,2.344982818,5.321525598,{"v":1.95e-14,"d":"1.95E-14"},{"v":5.17e-13,"d":"5.17E-13"},"ENSG00000143952","K7C879,Vacuolar protein sorting 54 homolog","-","PF10475,Vacuolar-sorting protein 54, of GARP complex;PF07928,Vps54-like protein","IPR012501,Vps54-likeVacuolar protein sorting-associated protein 54, C-terminal;IPR019515,Vacuolar protein sorting-associated protein 54, N-terminal","KOG2115,Vacuolar sorting protein VPS45;ENOG410XQ3K,-","GO:0005829,cellular_component,cytosol;GO:0042147,biological_process,retrograde transport, endosome to Golgi","-"]
["UBXN2B",12.68803745,2.492430658,2.344877931,5.391711801,{"v":7.34e-15,"d":"7.34E-15"},{"v":2.18e-13,"d":"2.18E-13"},"ENSG00000215114","H2RBA4,UBX domain protein 2B","XP_001156049.1,-","PF00789,UBX domain;PF08059,SEP domain","IPR029071,Ubiquitin-like domain superfamily;IPR012989,SEP domain;IPR001012,UBX domain;IPR036241,NSFL1 cofactor p47, SEP domain superfamily","ENOG410YGXU,-;KOG2086,Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion","GO:0019888,molecular_function,protein phosphatase regulator activity;GO:0061025,biological_process,membrane fusion;GO:0000045,biological_process,autophagosome assembly;GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0031468,biological_process,nuclear envelope reassembly;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0007030,biological_process,Golgi organization;GO:0043130,molecular_function,ubiquitin binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["FLRT3",15.41889575,3.030413365,2.344579466,5.613462488,{"v":5.81e-16,"d":"5.81E-16"},{"v":2.21e-14,"d":"2.21E-14"},"ENSG00000125848","H2QJZ5,Uncharacterized protein","XP_525271.2,-;XP_009435101.2,leucine-rich repeat transmembrane protein FLRT3;XP_001136869.2,-","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR003961,Fibronectin type III;IPR000483,Cysteine-rich flanking region, C-terminal;IPR036116,Fibronectin type III superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR000372,Leucine-rich repeat N-terminal domain;IPR003591,Leucine-rich repeat, typical subtype;IPR013783,Immunoglobulin-like fold","ENOG410IIEA,-;COG4886,Leucine-rich repeat (LRR) protein","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0098742,biological_process,cell-cell adhesion via plasma-membrane adhesion molecules;GO:0045499,molecular_function,chemorepellent activity;GO:0007416,biological_process,synapse assembly;GO:0005886,cellular_component,plasma membrane;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0005925,cellular_component,focal adhesion;GO:0005615,cellular_component,extracellular space;GO:0005104,molecular_function,fibroblast growth factor receptor binding;GO:0004860,molecular_function,protein kinase inhibitor activity;GO:0007507,biological_process,heart development;GO:0005737,cellular_component,cytoplasm;GO:0046426,biological_process,negative regulation of JAK-STAT cascade;GO:0003345,biological_process,proepicardium cell migration involved in pericardium morphogenesis;GO:0050919,biological_process,negative chemotaxis;GO:0005829,cellular_component,cytosol;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:1990138,biological_process,neuron projection extension;GO:0044295,cellular_component,axonal growth cone;GO:0030054,cellular_component,cell junction;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0007411,biological_process,axon guidance;GO:0060322,biological_process,head development;GO:0016020,cellular_component,membrane;GO:0048598,biological_process,embryonic morphogenesis;GO:0005911,cellular_component,cell-cell junction;GO:0008543,biological_process,fibroblast growth factor receptor signaling pathway;GO:0031175,biological_process,neuron projection development;GO:0042803,molecular_function,protein homodimerization activity","-"]
["SIN3A",27.26796818,5.367649787,2.344248274,7.674841419,{"v":2.38e-23,"d":"2.38E-23"},{"v":3.19e-21,"d":"3.19E-21"},"ENSG00000169375","H2NNU3,SIN3 transcription regulator family member A","-","PF02671,Paired amphipathic helix repeat;PF16879,C-terminal domain of Sin3a protein;PF08295,Sin3 family co-repressor","IPR037969,Paired amphipathic helix protein Sin3a;IPR031693,Sin3, C-terminal;IPR013194,Histone deacetylase interacting domain;IPR036600,Paired amphipathic helix superfamily;IPR003822,Paired amphipathic helix","KOG4204,Histone deacetylase complex, SIN3 component;COG5602,Histone deacetylase complex, SIN3 component","GO:1900181,biological_process,negative regulation of protein localization to nucleus;GO:0001103,molecular_function,RNA polymerase II repressing transcription factor binding;GO:2000678,biological_process,negative regulation of transcription regulatory region DNA binding;GO:0000776,cellular_component,kinetochore;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0002218,biological_process,activation of innate immune response;GO:0003714,molecular_function,transcription corepressor activity;GO:0008134,molecular_function,transcription factor binding;GO:0005634,cellular_component,nucleus;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0033558,molecular_function,protein deacetylase activity;GO:0006476,biological_process,protein deacetylation;GO:1901675,biological_process,negative regulation of histone H3-K27 acetylation;GO:0002230,biological_process,positive regulation of defense response to virus by host;GO:0010971,biological_process,positive regulation of G2/M transition of mitotic cell cycle;GO:0034613,biological_process,cellular protein localization;GO:0001102,molecular_function,RNA polymerase II activating transcription factor binding;GO:0003682,molecular_function,chromatin binding;GO:0016580,cellular_component,Sin3 complex;GO:0003677,molecular_function,DNA binding;GO:0006260,biological_process,DNA replication;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0031937,biological_process,positive regulation of chromatin silencing;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001106,molecular_function,RNA polymerase II transcription corepressor activity;GO:0005654,cellular_component,nucleoplasm;GO:0071333,biological_process,cellular response to glucose stimulus;GO:0005667,cellular_component,transcription factor complex;GO:0017053,cellular_component,transcriptional repressor complex;GO:0001701,biological_process,in utero embryonic development;GO:0042754,biological_process,negative regulation of circadian rhythm;GO:0051595,biological_process,response to methylglyoxal","-"]
["EEF2KMT",13.28501452,2.618793519,2.337970691,4.694944999,{"v":1.6E-11,"d":"1.60E-11"},{"v":2.2e-10,"d":"2.20E-10"},"ENSG00000118894","K7CAR1,Family with sequence similarity 86, member A","XP_016784858.1,protein-lysine N-methyltransferase EEF2KMT isoform X1","PF10294,Lysine methyltransferase;PF14904,amily of unknown function","IPR029426,FAM86;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR019410,Lysine methyltransferase","-","GO:0005737,cellular_component,cytoplasm;GO:0016279,molecular_function,protein-lysine N-methyltransferase activity;GO:0018023,biological_process,peptidyl-lysine trimethylation;GO:0032991,cellular_component,protein-containing complex","-"]
["PIAS2",2.181267952,0.429979987,2.337549676,4.579107482,{"v":3.52e-11,"d":"3.52E-11"},{"v":4.47e-10,"d":"4.47E-10"},"ENSG00000078043","K7B8T0,Protein inhibitor of activated STAT, 2","XP_016789127.1,-","PF14324,PINIT domain;PF02891,MIZ/SP-RING zinc finger","IPR027228,E3 SUMO-protein ligase PIAS2;IPR004181,Zinc finger, MIZ-type;IPR038654,PINIT domain superfamily;IPR023321,PINIT domain;IPR036361,SAP domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR003034,SAP domain","ENOG410XQ2E,-;KOG2169,Zn-finger transcription factor","GO:0016925,biological_process,protein sumoylation;GO:0016605,cellular_component,PML body;GO:0003677,molecular_function,DNA binding;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0045667,biological_process,regulation of osteoblast differentiation;GO:0019789,molecular_function,SUMO transferase activity;GO:0005654,cellular_component,nucleoplasm;GO:0016604,cellular_component,nuclear body;GO:0061665,molecular_function,SUMO ligase activity;GO:0008270,molecular_function,zinc ion binding;GO:0060766,biological_process,negative regulation of androgen receptor signaling pathway","-"]
["VTCN1",10.98262978,2.164938521,2.336760768,4.385630561,1.88E-10,{"v":2.02e-09,"d":"2.02E-09"},"ENSG00000134258","Q5T2L0,V-set domain-containing T-cell activation inhibitor 1","-","PF07686,Immunoglobulin V-set domain","IPR003599,Immunoglobulin subtype;IPR013783,Immunoglobulin-like fold;IPR036179,Immunoglobulin-like domain superfamily;IPR013106,Immunoglobulin V-set domain;IPR007110,Immunoglobulin-like domain","ENOG410IKB5,-;ENOG4111T2B,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["JAZF1",7.029292858,1.385641434,2.335694446,4.161824263,{"v":2.66e-09,"d":"2.66E-09"},{"v":2.22E-8,"d":"2.22E-08"},"ENSG00000153814","U5PYX6,JAZF1","NP_001302659.1,-","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","COG5189,Putative transcriptional repressor regulating G2/M transition;KOG4124,Putative transcriptional repressor regulating G2/M transition","GO:0003676,molecular_function,nucleic acid binding;GO:0017053,cellular_component,transcriptional repressor complex;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0003714,molecular_function,transcription corepressor activity;GO:0005829,cellular_component,cytosol;GO:0001650,cellular_component,fibrillar center;GO:0005634,cellular_component,nucleus","-"]
["RAVER2",9.819192169,1.943308735,2.333718481,5.199997682,{"v":6.14e-14,"d":"6.14E-14"},1.46E-12,"ENSG00000162437","H2PZ65,Uncharacterized protein","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR000504,RNA recognition motif domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR035979,RNA-binding domain superfamily;IPR034636,Ribonucleoprotein PTB-binding 2","ENOG410XSBX,-;ENOG410IJ9Q,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0005634,cellular_component,nucleus","-"]
["RP13-638C3.4",18.15871699,3.579516627,2.333510797,3.795504793,{"v":6.74e-08,"d":"6.74E-08"},{"v":4.11e-07,"d":"4.11E-07"},"ENSG00000261845","Q9H0E4,Uncharacterized protein DKFZp434D1428","-","-","-","-","-","-"]
["ABI3BP",11.44255938,2.268393316,2.333069595,6.254818979,{"v":1.86e-18,"d":"1.86E-18"},1.17E-16,"ENSG00000154175","D3YTG3,Target of Nesh-SH3","XP_005247340.1,target of Nesh-SH3 isoform X3","PF00041,ibronectin type III domain","IPR003961,Fibronectin type III;IPR036116,Fibronectin type III superfamily;IPR013783,Immunoglobulin-like fold","-","-","-"]
["ZNF608",2.88163135,0.568038333,2.332738605,3.687037243,{"v":2.03E-7,"d":"2.03E-07"},{"v":1.11E-6,"d":"1.11E-06"},"ENSG00000168916","G3RI70,Zinc finger protein 608","-","-","IPR013087,Zinc finger C2H2-type","-","GO:0003676,molecular_function,nucleic acid binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II","-"]
["MTUS1",4.270723679,0.845759101,2.332249176,4.989634928,{"v":5.78e-13,"d":"5.78E-13"},{"v":1.11e-11,"d":"1.11E-11"},"ENSG00000129422","K7CHJ5,Microtubule associated tumor suppressor 1","XP_016814628.1,microtubule-associated tumor suppressor 1 isoform X2","-","IPR029786,Microtubule-associated tumour suppressor 1","ENOG41118DX,-;ENOG410IEXM,-","GO:0015630,cellular_component,microtubule cytoskeleton;GO:0005730,cellular_component,nucleolus","-"]
["SOHLH2",4.890323675,0.963999544,2.330733792,3.44156034,{"v":9.3e-07,"d":"9.30E-07"},{"v":4.41e-06,"d":"4.41E-06"},"ENSG00000120669","A0A140VK50,Testicular secretory protein Li 50","-","PF00010,Helix-loop-helix DNA-binding domain","IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR032669,Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2","-","GO:0007283,biological_process,spermatogenesis;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0046983,molecular_function,protein dimerization activity;GO:0048477,biological_process,oogenesis","-"]
["COBLL1",4.036463059,0.801133118,2.330089915,5.413460833,{"v":6.48e-15,"d":"6.48E-15"},1.95E-13,"ENSG00000082438","A0A0D9SG04,Cordon-bleu protein-like 1","NP_001265387.1,cordon-bleu protein-like 1 isoform 1","PF09469,Cordon-bleu ubiquitin-like domain","IPR003124,WH2 domain;IPR019025,Cordon-bleu, ubiquitin-like domain","-","GO:0003779,molecular_function,actin binding","-"]
["REXO1",7.947310113,1.575608026,2.329709937,4.688228019,{"v":1.6E-11,"d":"1.60E-11"},{"v":2.2e-10,"d":"2.20E-10"},"ENSG00000079313","G1QN63,RNA exonuclease 1 homolog","-","PF15870,longinA binding-protein 1","IPR036397,Ribonuclease H superfamily;IPR034922,RNA exonuclease 1-like, exonuclease domain;IPR013520,Exonuclease, RNase T/DNA polymerase III;IPR031736,Elongin A binding-protein 1;IPR012337,Ribonuclease H-like superfamily","KOG2248,3'-5' exonuclease;COG0847,DNA polymerase III, epsilon subunit and related 3'-5' exonucleases","GO:0003676,molecular_function,nucleic acid binding;GO:0016604,cellular_component,nuclear body;GO:0005654,cellular_component,nucleoplasm","K14570,ko03008,Ribosome biogenesis in eukaryotes"]
["RP5-850E9.3",24.3234784,4.829232794,2.329451847,5.344350496,{"v":1.7E-14,"d":"1.70E-14"},{"v":4.58e-13,"d":"4.58E-13"},"ENSG00000270299","S4R3F8,Uncharacterized protein","-","-","IPR029794,Transcriptional repressor SCRATCH 1/2","KOG2462,C2H2-type Zn-finger protein;ENOG41106JS,-","-","-"]
["RP11-54H7.4",3.557666862,0.701301072,2.329399563,3.300791261,{"v":3.25e-06,"d":"3.25E-06"},{"v":1.37e-05,"d":"1.37E-05"},"ENSG00000275216","A0A1A9AL28,Uncharacterized protein","-","-","-","-","-","-"]
["RALGAPA1",2.78130483,0.551544584,2.329163249,4.631205435,2.11E-11,{"v":2.83e-10,"d":"2.83E-10"},"ENSG00000174373","A0A1B0GUI1,Ral GTPase-activating protein subunit alpha-1","NP_001317004.1,ral GTPase-activating protein subunit alpha-1 isoform 5;NP_001333177.1,-","PF02145,Rap/ran-GAP","IPR016024,Armadillo-type fold;IPR027107,Tuberin/Ral GTPase-activating protein subunit alpha;IPR035974,Rap/Ran-GAP superfamily;IPR000331,Rap GTPase activating protein domain","-","GO:0005737,cellular_component,cytoplasm;GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0005634,cellular_component,nucleus","-"]
["SLCO3A1",1.409408387,0.27782804,2.327734369,3.144451748,{"v":5.01e-06,"d":"5.01E-06"},{"v":2.04e-05,"d":"2.04E-05"},"ENSG00000176463","F7GM07,Solute carrier organic anion transporter family member","XP_014998543.1,-","PF07648,Kazal-type serine protease inhibitor domain;PF03137,Organic Anion Transporter Polypeptide (OATP) family","IPR036259,MFS transporter superfamily;IPR004156,Organic anion transporter polypeptide;IPR002350,Kazal domain;IPR020846,Major facilitator superfamily domain;IPR036058,Kazal domain superfamily","ENOG410XRSF,-;KOG3626,Organic anion transporter","GO:0055085,biological_process,transmembrane transport;GO:0006811,biological_process,ion transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0005215,molecular_function,transporter activity;GO:0016021,cellular_component,integral component of membrane","-"]
["ZNF543",3.63426295,0.716399989,2.327734369,3.144451748,{"v":5.01e-06,"d":"5.01E-06"},{"v":2.04e-05,"d":"2.04E-05"},"ENSG00000178229","H2QH98,Uncharacterized protein","XP_003316789.2,zinc finger protein 543 isoform X1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["FAT3",5.123621392,1.019699518,2.326998736,5.914403336,{"v":5.55e-17,"d":"5.55E-17"},{"v":2.58e-15,"d":"2.58E-15"},"ENSG00000165323","H2R0J8,Uncharacterized protein","XP_016777274.1,protocadherin Fat 3 isoform X5","PF02210,Laminin G domain;PF00028,Cadherin domain","IPR002126,Cadherin;IPR015919,Cadherin-like;IPR018097,EGF-like calcium-binding, conserved site;IPR001791,Laminin G domain;IPR001881,EGF-like calcium-binding domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR020894,Cadherin conserved site","KOG1219,Uncharacterized conserved protein, contains laminin, cadherin and EGF domains;ENOG410XPEI,-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["WEE1",5.705828797,1.134888001,2.326099967,5.028953113,{"v":3.89e-13,"d":"3.89E-13"},{"v":7.78e-12,"d":"7.78E-12"},"ENSG00000166483","Q6NSL2,Wee1-like protein kinase","-","PF00069,Protein kinase domain","IPR017164,Wee1-like protein kinase;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XS1M,-;KOG0601,Cyclin-dependent kinase WEE1","GO:0016301,molecular_function,kinase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0005634,cellular_component,nucleus;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0005524,molecular_function,ATP binding;GO:0004715,molecular_function,non-membrane spanning protein tyrosine kinase activity;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0000278,biological_process,mitotic cell cycle;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0000287,molecular_function,magnesium ion binding","-"]
["INVS",8.87029316,1.764299216,2.326099967,5.028953113,{"v":3.89e-13,"d":"3.89E-13"},{"v":7.78e-12,"d":"7.78E-12"},"ENSG00000119509","A0A024R153,Inversin, isoform CRA_a","NP_055240.2,inversin isoform a","PF12796,Ankyrin repeats (3 copies);PF00612,IQ calmodulin-binding motif","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily;IPR000048,IQ motif, EF-hand binding site","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","-","K19626,ko04310,Wnt signaling pathway"]
["ARL15",3.064405351,0.604067452,2.325597626,2.968624548,{"v":1.98E-5,"d":"1.98E-05"},{"v":7.06e-05,"d":"7.06E-05"},"ENSG00000185305","K7AXD4,ADP-ribosylation factor-like 15","XP_517765.2,-","PF00025,ADP-ribosylation factor family","IPR006689,Small GTPase superfamily, ARF/SAR type;IPR024156,Small GTPase superfamily, ARF type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0071,GTP-binding ADP-ribosylation factor Arf6 (dArf3);ENOG410XP1U,-","GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular","-"]
["ZFP64",4.242177813,0.842924398,2.324606866,4.231126168,{"v":1.4e-09,"d":"1.40E-09"},{"v":1.25e-08,"d":"1.25E-08"},"ENSG00000020256","G3R8L8,ZFP64 zinc finger protein","-","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type;PF13912,C2H2-type zinc finger;PF13909,C2H2-type zinc-finger domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["JARID2",29.49006293,5.883233927,2.324424939,6.74821667,{"v":3.26e-20,"d":"3.26E-20"},2.76E-18,"ENSG00000008083","G3QS10,Jumonji and AT-rich interaction domain containing 2","XP_004043354.1,protein Jumonji isoform X3;XP_018885226.1,-","PF02375,jmjN domain;PF02928,C5HC2 zinc finger;PF01388,ARID/BRIGHT DNA binding domain;PF02373,JmjC domain, hydroxylase","IPR003349,JmjN domain;IPR004198,Zinc finger, C5HC2-type;IPR001606,ARID DNA-binding domain;IPR036431,ARID DNA-binding domain superfamily;IPR003347,JmjC domain","-","GO:0042127,biological_process,regulation of cell proliferation;GO:0048538,biological_process,thymus development;GO:0003677,molecular_function,DNA binding;GO:0001889,biological_process,liver development;GO:0048863,biological_process,stem cell differentiation;GO:0048536,biological_process,spleen development;GO:0051574,biological_process,positive regulation of histone H3-K9 methylation;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0035097,cellular_component,histone methyltransferase complex;GO:0035098,cellular_component,ESC/E(Z) complex;GO:0008134,molecular_function,transcription factor binding;GO:0005739,cellular_component,mitochondrion;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0031061,biological_process,negative regulation of histone methylation;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["GTF2IRD1",4.312141758,0.857229696,2.323534606,4.152033871,{"v":3.52e-09,"d":"3.52E-09"},{"v":2.87e-08,"d":"2.87E-08"},"ENSG00000006704","F6ZAQ6,GTF2I repeat domain containing 1","-","PF02946,TF2I-like repeat","IPR016659,Transcription factor II-I;IPR004212,GTF2I-like repeat;IPR036647,GTF2I-like repeat superfamily","ENOG410IEPZ,-;ENOG41100H8,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0007275,biological_process,multicellular organism development;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0006351,biological_process,transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["APBB2",3.427373199,0.682842931,2.322993338,4.789632234,{"v":4.93e-12,"d":"4.93E-12"},{"v":7.56e-11,"d":"7.56E-11"},"ENSG00000163697","K6ZGE2,Amyloid beta","XP_001146547.2,amyloid beta A4 precursor protein-binding family B member 2 isoform X6","PF00397,WW domain;PF00640,Phosphotyrosine interaction domain (PTB/PID)","IPR001202,WW domain;IPR036020,WW domain superfamily;IPR006020,PTB/PI domain;IPR011993,PH-like domain superfamily","ENOG410YEVS,-;ENOG410IEKA,-","-","-"]
["RP11-638I2.8",25.90474312,5.1064433,2.322755992,2.767693238,{"v":8.39e-05,"d":"8.39E-05"},2.58025E-4,"ENSG00000258666","C4WWS8,ACYPI005300 protein","NP_001155620.1,tryptophanyl-tRNA synthetase-like","PF00579,tRNA synthetases class I (W and Y)","IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR002305,Aminoacyl-tRNA synthetase, class Ic;IPR002306,Tryptophan-tRNA ligase;IPR001412,Aminoacyl-tRNA synthetase, class I, conserved site","KOG2145,Cytoplasmic tryptophanyl-tRNA synthetase;COG0180,Tryptophanyl-tRNA synthetase","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0006412,biological_process,translation;GO:0016874,molecular_function,ligase activity;GO:0006436,biological_process,tryptophanyl-tRNA aminoacylation;GO:0004830,molecular_function,tryptophan-tRNA ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","K01867,ko00970,Aminoacyl-tRNA biosynthesis"]
["CTD-2002J20.1",16.79011128,3.309731768,2.322755992,2.767693238,{"v":8.39e-05,"d":"8.39E-05"},2.58025E-4,"-","-","-","-","-","-","-","-"]
["ARHGAP26",3.077890547,0.613739876,2.32140161,4.681478947,{"v":2.02e-11,"d":"2.02E-11"},{"v":2.73e-10,"d":"2.73E-10"},"ENSG00000145819","H2PGX3,Rho GTPase activating protein 26","XP_009239421.1,rho GTPase-activating protein 26 isoform X1","PF14604,Variant SH3 domain;PF16746,BAR domain of APPL family;PF00620,RhoGAP domain;PF00169,PH domain","IPR035481,GRAF, SH3 domain;IPR001849,Pleckstrin homology domain;IPR035483,GRAF, BAR domain;IPR030061,Rho GTPase-activating protein 26;IPR027267,AH/BAR domain superfamily;IPR008936,Rho GTPase activation protein;IPR001452,SH3 domain;IPR000198,Rho GTPase-activating protein domain;IPR011993,PH-like domain superfamily;IPR036028,SH3-like domain superfamily","ENOG410YJPS,-;KOG1451,Oligophrenin-1 and related Rho GTPase-activating proteins","GO:0030036,biological_process,actin cytoskeleton organization;GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0005543,molecular_function,phospholipid binding;GO:0007165,biological_process,signal transduction","-"]
["FAM65A",14.85669805,2.970347771,2.320424067,5.932401721,{"v":5.2e-17,"d":"5.20E-17"},2.45E-15,"ENSG00000039523","A0A0A0MTL6,Rho family-interacting cell polarization regulator 1","-","PF13646,HEAT repeats;PF15903,ilopodia upregulated, FAM65","IPR011989,Armadillo-like helical;IPR026136,RIPOR family member 3;IPR031780,FAM65, N-terminal;IPR016024,Armadillo-type fold","ENOG410IGQR,-;ENOG410ZI73,-","-","-"]
["ANXA8L1",7.541567506,1.506183826,2.320298275,5.067225151,{"v":2.64e-13,"d":"2.64E-13"},{"v":5.55e-12,"d":"5.55E-12"},"ENSG00000264230","A0A075B752,Annexin","-","PF00191,Annexin","IPR037104,Annexin superfamily;IPR018502,Annexin repeat;IPR001464,Annexin;IPR018252,Annexin repeat, conserved site;IPR009115,Annexin A8","-","GO:0005544,molecular_function,calcium-dependent phospholipid binding;GO:0005509,molecular_function,calcium ion binding","-"]
["DUSP16",8.877790198,1.774557442,2.318837702,4.978694391,8.76E-13,{"v":1.61e-11,"d":"1.61E-11"},"ENSG00000111266","A0A024RAR2,Dual specificity phosphatase 16, isoform CRA_a","XP_006719218.1,-;XP_011519158.1,-;XP_011519159.1,-;NP_085143.1,dual specificity protein phosphatase 16","PF00581,Rhodanese-like domain;PF00782,ual specificity phosphatase, catalytic domain","IPR008343,Mitogen-activated protein (MAP) kinase phosphatase;IPR036873,Rhodanese-like domain superfamily;IPR029021,Protein-tyrosine phosphatase-like;IPR016130,Protein-tyrosine phosphatase, active site;IPR000340,Dual specificity phosphatase, catalytic domain;IPR001763,Rhodanese-like domain;IPR020422,Dual specificity protein phosphatase domain;IPR000387,Tyrosine specific protein phosphatases domain;IPR024950,Dual specificity phosphatase","COG2453,Predicted protein-tyrosine phosphatase;KOG1716,Dual specificity phosphatase","GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0000188,biological_process,inactivation of MAPK activity;GO:0043409,biological_process,negative regulation of MAPK cascade;GO:0006470,biological_process,protein dephosphorylation;GO:0017017,molecular_function,MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0005829,cellular_component,cytosol;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K04459,ko04010,MAPK signaling pathway"]
["RUNX2",6.203182506,1.239937353,2.318837702,4.978694391,8.76E-13,{"v":1.61e-11,"d":"1.61E-11"},"ENSG00000124813","I3L0L0,Runt-related transcription factor 2","-","PF00853,Runt domain","IPR012346,p53/RUNT-type transcription factor, DNA-binding domain superfamily;IPR000040,Acute myeloid leukemia 1 protein (AML1)/Runt;IPR008967,p53-like transcription factor, DNA-binding;IPR013524,Runt domain","ENOG4111J4Y,-;KOG3982,Runt and related transcription factors","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005524,molecular_function,ATP binding;GO:0005634,cellular_component,nucleus","-"]
["BCL9L",32.93143562,6.603341634,2.317623152,7.701110262,{"v":5.15e-23,"d":"5.15E-23"},{"v":6.64e-21,"d":"6.64E-21"},"ENSG00000186174","H2NFI4,B-cell CLL/lymphoma 9 like","-","PF11502,B-cell lymphoma 9 protein","IPR015668,B Cell Lymphoma 9;IPR024670,B-cell lymphoma 9, beta-catenin binding domain;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XRMX,-;ENOG410IEDB,-","GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0022604,biological_process,regulation of cell morphogenesis;GO:0005730,cellular_component,nucleolus;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0003713,molecular_function,transcription coactivator activity;GO:0035019,biological_process,somatic stem cell population maintenance;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0008013,molecular_function,beta-catenin binding;GO:1990907,cellular_component,beta-catenin-TCF complex;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0030512,biological_process,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["OPHN1",2.598664041,0.517950485,2.317594746,3.782800818,{"v":9.22e-08,"d":"9.22E-08"},{"v":5.45e-07,"d":"5.45E-07"},"ENSG00000079482","H2PVW4,Oligophrenin 1","-","PF16746,BAR domain of APPL family;PF00620,RhoGAP domain;PF00169,PH domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain;IPR027267,AH/BAR domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","ENOG410YJPS,-;KOG1451,Oligophrenin-1 and related Rho GTPase-activating proteins","GO:0048667,biological_process,cell morphogenesis involved in neuron differentiation;GO:0021895,biological_process,cerebral cortex neuron differentiation;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0030182,biological_process,neuron differentiation;GO:0005737,cellular_component,cytoplasm;GO:0034329,biological_process,cell junction assembly;GO:0030036,biological_process,actin cytoskeleton organization;GO:0030100,biological_process,regulation of endocytosis;GO:0051966,biological_process,regulation of synaptic transmission, glutamatergic;GO:0030425,cellular_component,dendrite;GO:0015629,cellular_component,actin cytoskeleton;GO:0003779,molecular_function,actin binding;GO:0043197,cellular_component,dendritic spine;GO:1901799,biological_process,negative regulation of proteasomal protein catabolic process;GO:0007165,biological_process,signal transduction;GO:0045198,biological_process,establishment of epithelial cell apical/basal polarity;GO:0048488,biological_process,synaptic vesicle endocytosis;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0021707,biological_process,cerebellar granule cell differentiation;GO:0043195,cellular_component,terminal bouton;GO:0031175,biological_process,neuron projection development;GO:0005543,molecular_function,phospholipid binding","-"]
["AC027682.1",26.8100164,5.372975847,2.316994344,5.929579053,{"v":5.95e-17,"d":"5.95E-17"},{"v":2.76e-15,"d":"2.76E-15"},"ENSG00000283332","A0A0A0MTL6,Rho family-interacting cell polarization regulator 1","-","PF13646,HEAT repeats;PF15903,ilopodia upregulated, FAM65","IPR011989,Armadillo-like helical;IPR026136,RIPOR family member 3;IPR031780,FAM65, N-terminal;IPR016024,Armadillo-type fold","ENOG410IGQR,-;ENOG410ZI73,-","-","-"]
["DESI2",8.979194365,1.797526736,2.316253459,4.834734228,{"v":3.14e-12,"d":"3.14E-12"},5.05E-11,"ENSG00000121644","H0UXQ9,Desumoylating isopeptidase 2","XP_003474304.2,desumoylating isopeptidase 2","PF05903,PPPDE putative peptidase domain","IPR008580,PPPDE putative peptidase domain","ENOG4111H3Z,-;KOG0324,Uncharacterized conserved protein","GO:0005737,cellular_component,cytoplasm","-"]
["GALNT10",4.366407016,0.874102178,2.316253459,4.834734228,{"v":3.14e-12,"d":"3.14E-12"},5.05E-11,"ENSG00000164574","A0A096MKR6,Polypeptide N-acetylgalactosaminyltransferase","XP_017815554.1,polypeptide N-acetylgalactosaminyltransferase 10","PF00535,lycosyl transferase family 2;PF00652,Ricin-type beta-trefoil lectin domain","IPR035992,Ricin B-like lectins;IPR000772,Ricin B, lectin domain;IPR029044,Nucleotide-diphospho-sugar transferases;IPR001173,Glycosyltransferase 2-like","-","GO:0005794,cellular_component,Golgi apparatus;GO:0016020,cellular_component,membrane;GO:0006486,biological_process,protein glycosylation;GO:0016740,molecular_function,transferase activity;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016266,biological_process,O-glycan processing;GO:0030246,molecular_function,carbohydrate binding;GO:0004653,molecular_function,polypeptide N-acetylgalactosaminyltransferase activity;GO:0000139,cellular_component,Golgi membrane;GO:0006493,biological_process,protein O-linked glycosylation;GO:0016021,cellular_component,integral component of membrane","-"]
["HOXA1",21.23019022,4.258721421,2.313960786,5.062054671,{"v":3.23e-13,"d":"3.23E-13"},6.59E-12,"ENSG00000105991","G3QIG4,Homeobox A1","XP_004045264.1,homeobox protein Hox-A1 isoform X1","PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR020479,Homeobox domain, metazoa;IPR009057,Homeobox-like domain superfamily","-","GO:0043565,molecular_function,sequence-specific DNA binding;GO:0007634,biological_process,optokinetic behavior;GO:0042473,biological_process,outer ear morphogenesis;GO:0003677,molecular_function,DNA binding;GO:0090102,biological_process,cochlea development;GO:0090103,biological_process,cochlea morphogenesis;GO:0048844,biological_process,artery morphogenesis;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0007605,biological_process,sensory perception of sound;GO:0050795,biological_process,regulation of behavior;GO:0060840,biological_process,artery development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0021599,biological_process,abducens nerve formation;GO:0048839,biological_process,inner ear development;GO:0060876,biological_process,semicircular canal formation;GO:0050890,biological_process,cognition;GO:0048702,biological_process,embryonic neurocranium morphogenesis;GO:0009653,biological_process,anatomical structure morphogenesis;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0050905,biological_process,neuromuscular process","-"]
["NR5A2",5.403247121,1.083686483,2.313045159,4.674697469,{"v":2.55e-11,"d":"2.55E-11"},{"v":3.36e-10,"d":"3.36E-10"},"ENSG00000116833","G3R3Z2,Nuclear receptor subfamily 5 group A member 2","XP_004028157.1,-","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR016355,Nuclear hormone receptor family 5;IPR013088,Zinc finger, NHR/GATA-type","-","GO:0030855,biological_process,epithelial cell differentiation;GO:0008206,biological_process,bile acid metabolic process;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0000980,molecular_function,RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway;GO:0061113,biological_process,pancreas morphogenesis;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003682,molecular_function,chromatin binding;GO:0042127,biological_process,regulation of cell proliferation;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0090575,cellular_component,RNA polymerase II transcription factor complex;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0008270,molecular_function,zinc ion binding;GO:0045070,biological_process,positive regulation of viral genome replication;GO:0046872,molecular_function,metal ion binding;GO:0005543,molecular_function,phospholipid binding;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0042632,biological_process,cholesterol homeostasis","K08027,ko04950,Maturity onset diabetes of the young"]
["TNFSF10",11.76019147,2.358648467,2.313045159,4.674697469,{"v":2.55e-11,"d":"2.55E-11"},{"v":3.36e-10,"d":"3.36E-10"},"ENSG00000121858","Q6IBA9,TNFSF10 protein","NP_003801.1,tumor necrosis factor ligand superfamily member 10 isoform 1","PF00229,TNF(Tumour Necrosis Factor) family","IPR017355,Tumour necrosis factor ligand 10/11;IPR006052,Tumour necrosis factor domain;IPR021184,Tumour necrosis factor, conserved site;IPR008983,Tumour necrosis factor-like domain superfamily","ENOG410YS4F,-;ENOG410IIX7,-","GO:0010469,biological_process,regulation of signaling receptor activity;GO:0032813,molecular_function,tumor necrosis factor receptor superfamily binding;GO:0005125,molecular_function,cytokine activity;GO:0032868,biological_process,response to insulin;GO:0005164,molecular_function,tumor necrosis factor receptor binding;GO:2001238,biological_process,positive regulation of extrinsic apoptotic signaling pathway;GO:0046872,molecular_function,metal ion binding;GO:0006955,biological_process,immune response;GO:0008584,biological_process,male gonad development;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0005615,cellular_component,extracellular space","K04721,ko04210,Apoptosis;K04721,ko05164,Influenza A;K04721,ko04060,Cytokine-cytokine receptor interaction;K04721,ko04650,Natural killer cell mediated cytotoxicity;K04721,ko04068,FoxO signaling pathway;K04721,ko05162,Measles"]
["DENND2C",0.896922173,0.176804773,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000175984","H2RCK2,Uncharacterized protein","XP_009426984.2,DENN domain-containing protein 2C isoform X2","PF02141,NN (AEX-3) domain;PF03455,dDENN domain;PF03456,uDENN domain","IPR001194,cDENN domain;IPR005113,uDENN domain;IPR037516,Tripartite DENN domain;IPR005112,dDENN domain","KOG3569,RAS signaling inhibitor ST5;ENOG410XT3N,-","-","-"]
["NOS1AP",0.855602119,0.168659604,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000198929","G7NXC3,Uncharacterized protein","-","PF00640,Phosphotyrosine interaction domain (PTB/PID)","IPR006020,PTB/PI domain;IPR011993,PH-like domain superfamily","-","-","-"]
["CYP2R1",1.472294966,0.290224486,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000186104","H2Q380,Uncharacterized protein","-","PF00067,Cytochrome P450","IPR036396,Cytochrome P450 superfamily;IPR002401,Cytochrome P450, E-class, group I;IPR001128,Cytochrome P450;IPR017972,Cytochrome P450, conserved site","COG2124,Cytochrome P450;KOG0156,Cytochrome P450 CYP2 subfamily","GO:0030343,molecular_function,vitamin D3 25-hydroxylase activity;GO:0016705,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0008395,molecular_function,steroid hydroxylase activity;GO:0046872,molecular_function,metal ion binding;GO:0004497,molecular_function,monooxygenase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0005506,molecular_function,iron ion binding;GO:0055114,biological_process,oxidation-reduction process;GO:0020037,molecular_function,heme binding;GO:0042359,biological_process,vitamin D metabolic process;GO:0036378,biological_process,calcitriol biosynthetic process from calciol","-"]
["IKZF4",0.976628095,0.192516713,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000123411","G3R7D9,IKAROS family zinc finger 4","XP_004053396.2,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0032991,cellular_component,protein-containing complex;GO:0003676,molecular_function,nucleic acid binding;GO:0051260,biological_process,protein homooligomerization;GO:0019904,molecular_function,protein domain specific binding;GO:0051291,biological_process,protein heterooligomerization;GO:0016604,cellular_component,nuclear body;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-468E2.6",7.82221655,1.541945624,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000259371","H0YL77,Uncharacterized protein","-","-","IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR036322,WD40-repeat-containing domain superfamily","ENOG410XP3K,-;KOG0266,WD40 repeat-containing protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TMC5",1.040025664,0.205013887,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000103534","B7Z946,Transmembrane channel-like protein","NP_001248770.1,-","PF07810,TMC domain","IPR012496,TMC","ENOG410XR0Y,-;ENOG410IH09,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NPIPB11",1.511797196,0.298011319,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000254206","B4DHL8,cDNA FLJ54462","-","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);ENOG410J0WZ,-","-","-"]
["RP11-294J22.6",9.923707564,1.956199672,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000262967","F6YYL9,Uncharacterized protein","-","-","-","-","GO:0048741,biological_process,skeletal muscle fiber development","-"]
["FAAP24",2.805436316,0.553018473,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000131944","A0A0S2Z5V6,Chromosome 19 open reading frame 40 isoform 1","NP_689479.1,Fanconi anemia core complex-associated protein 24 isoform 1","PF12826,Helix-hairpin-helix motif","IPR026985,Fanconi anemia-associated protein of 24kDa;IPR010994,RuvA domain 2-like","-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0006281,biological_process,DNA repair;GO:0043240,cellular_component,Fanconi anaemia nuclear complex;GO:0005654,cellular_component,nucleoplasm","K10898,ko03460,Fanconi anemia pathway"]
["AC062029.1",1.552389463,0.306013024,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000234028","G7MFM1,Uncharacterized protein","-","-","-","-","-","-"]
["NEURL1B",1.03500686,0.204024561,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000214357","H2RDE4,Uncharacterized protein","XP_003311007.2,E3 ubiquitin-protein ligase NEURL1B isoform X1","PF13920,Zinc finger, C3HC4 type (RING finger);PF07177,Neuralized","IPR001841,Zinc finger, RING-type;IPR006573,Neuralized homology repeat (NHR) domain;IPR037962,Neuralized;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410ZMNG,-;KOG4172,Predicted E3 ubiquitin ligase;KOG4625,Notch signaling protein Neuralized, Nuez domain","-","-"]
["POPDC3",3.53476027,0.696785635,2.312875903,2.251478052,0.001177692,2.803224E-3,"ENSG00000132429","H2QTG9,Popeye domain containing 3","XP_518655.2,-;XP_016811549.1,-;XP_016811550.1,-","PF04831,Popeye protein conserved region","IPR006916,Popeye protein;IPR018490,Cyclic nucleotide-binding-like","ENOG410ZTIT,-;ENOG410IGHK,-","GO:0042391,biological_process,regulation of membrane potential;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0030552,molecular_function,cAMP binding","-"]
["STARD13",3.114045777,0.625013725,2.309289188,4.057837631,{"v":1.22E-8,"d":"1.22E-08"},{"v":8.83e-08,"d":"8.83E-08"},"ENSG00000133121","A0A024RDV4,START domain containing 13, isoform CRA_a","NP_821074.1,stAR-related lipid transfer protein 13 isoform 1","PF01852,START domain;PF07647,SAM domain (Sterile alpha motif);PF00620,RhoGAP domain","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR000198,Rho GTPase-activating protein domain;IPR008936,Rho GTPase activation protein;IPR023393,START-like domain superfamily;IPR001660,Sterile alpha motif domain;IPR002913,START domain","KOG2200,Tumour suppressor protein p122-RhoGAP/DLC1;ENOG410XQ10,-","GO:0008289,molecular_function,lipid binding;GO:0007165,biological_process,signal transduction","-"]
["MR1",7.82389011,1.577327239,2.307719017,5.492231197,{"v":6.58e-15,"d":"6.58E-15"},{"v":1.98e-13,"d":"1.98E-13"},"ENSG00000153029","H2Q0Q3,Major histocompatibility complex class I-related gene protein","-","PF07654,Immunoglobulin C1-set domain;PF00129,Class I Histocompatibility antigen, domains alpha 1 and 2","-","-","-","-"]
["METTL9",14.31174152,2.887723326,2.307245616,5.944597222,{"v":6.37e-17,"d":"6.37E-17"},{"v":2.9e-15,"d":"2.90E-15"},"ENSG00000197006","H2R0J0,Methyltransferase like 9","-","PF08241,Methyltransferase domain;PF13489,Methyltransferase domain;PF05219,REV methyltransferase;PF08242,Methyltransferase domain","IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR007884,DREV methyltransferase","KOG3987,Uncharacterized conserved protein DREV/CGI-81;ENOG41102YK,-","GO:0032259,biological_process,methylation;GO:0016740,molecular_function,transferase activity;GO:0008168,molecular_function,methyltransferase activity","-"]
["ALDH6A1",2.203971408,0.441462725,2.306369364,3.282685587,{"v":4.62e-06,"d":"4.62E-06"},{"v":1.89e-05,"d":"1.89E-05"},"ENSG00000119711","A0A024R6G4,Aldehyde dehydrogenase 6 family, member A1, isoform CRA_b","NP_005580.1,methylmalonate-semialdehyde dehydrogenase","PF00171,Aldehyde dehydrogenase family","IPR016163,Aldehyde dehydrogenase, C-terminal;IPR016161,Aldehyde/histidinol dehydrogenase;IPR016160,Aldehyde dehydrogenase, cysteine active site;IPR015590,Aldehyde dehydrogenase domain;IPR016162,Aldehyde dehydrogenase, N-terminal;IPR010061,Methylmalonate-semialdehyde dehydrogenase","KOG2449,Methylmalonate semialdehyde dehydrogenase;ENOG410XNP1,-","GO:0050873,biological_process,brown fat cell differentiation;GO:0016491,molecular_function,oxidoreductase activity;GO:0004491,molecular_function,methylmalonate-semialdehyde dehydrogenase (acylating) activity;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0016620,molecular_function,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0055114,biological_process,oxidation-reduction process;GO:0005654,cellular_component,nucleoplasm","K00140,ko01200,Carbon metabolism;K00140,ko00280,Valine, leucine and isoleucine degradation;K00140,ko00640,Propanoate metabolism;K00140,ko00562,Inositol phosphate metabolism;K00140,ko00410,beta-Alanine metabolism"]
["BTBD7",6.013505841,1.214317894,2.305184754,5.393062577,{"v":1.54e-14,"d":"1.54E-14"},{"v":4.24e-13,"d":"4.24E-13"},"ENSG00000011114","G3QUR1,BTB domain containing 7","XP_018865133.1,-;XP_004055649.1,BTB/POZ domain-containing protein 7 isoform X1","PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch","IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR011705,BTB/Kelch-associated","-","GO:0005634,cellular_component,nucleus;GO:0060693,biological_process,regulation of branching involved in salivary gland morphogenesis","-"]
["ATXN2",15.69660474,3.174805504,2.304817283,7.050800638,{"v":4.69e-21,"d":"4.69E-21"},{"v":4.6e-19,"d":"4.60E-19"},"ENSG00000204842","H2RCH3,Uncharacterized protein","-","PF07145,Ataxin-2 C-terminal region;PF06741,LsmAD domain;PF14438,Ataxin 2 SM domain","IPR010920,LSM domain superfamily;IPR033093,Ataxin-2;IPR009818,Ataxin-2, C-terminal;IPR025852,Ataxin 2, SM domain;IPR009604,LsmAD domain","KOG2375,Protein interacting with poly(A)-binding protein;COG5180,Protein interacting with poly(A)-binding protein","GO:0003723,molecular_function,RNA binding;GO:0010494,cellular_component,cytoplasmic stress granule;GO:0010603,biological_process,regulation of cytoplasmic mRNA processing body assembly;GO:0033962,biological_process,cytoplasmic mRNA processing body assembly;GO:0005737,cellular_component,cytoplasm;GO:0005154,molecular_function,epidermal growth factor receptor binding;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0002091,biological_process,negative regulation of receptor internalization;GO:0005802,cellular_component,trans-Golgi network;GO:0034063,biological_process,stress granule assembly;GO:0008022,molecular_function,protein C-terminus binding;GO:0005844,cellular_component,polysome;GO:0005829,cellular_component,cytosol;GO:0005794,cellular_component,Golgi apparatus;GO:0030529,,","-"]
["MAP3K12",5.094176997,1.027673583,2.304640023,4.667883269,{"v":3.22e-11,"d":"3.22E-11"},{"v":4.12e-10,"d":"4.12E-10"},"ENSG00000139625","Q5RCD1,Mitogen-activated protein kinase kinase kinase 12","NP_001125309.1,mitogen-activated protein kinase kinase kinase 12","PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR027257,Mitogen-activated protein kinase kinase kinase 12;IPR017419,Mitogen-activated protein kinase kinase kinase 12/13;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410YKX2,-;KOG4721,Serine/threonine protein kinase, contains leucine zipper domain","GO:0016301,molecular_function,kinase activity;GO:0046777,biological_process,protein autophosphorylation;GO:0000186,biological_process,activation of MAPKK activity;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0007254,biological_process,JNK cascade;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005622,cellular_component,intracellular;GO:0004709,molecular_function,MAP kinase kinase kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","K04423,ko04010,MAPK signaling pathway"]
["RP11-394J1.2",58.79965502,11.85829611,2.303564241,4.288332342,{"v":7.55e-10,"d":"7.55E-10"},{"v":7.12e-09,"d":"7.12E-09"},"ENSG00000258177","S9XUY7,ETS domain-containing protein Elk-3","-","PF00178,ts-domain","IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000418,Ets domain","-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0016020,cellular_component,membrane;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","-"]
["LINC01138",1.266293309,0.249616642,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000274020","H2N617,Uncharacterized protein","-","-","-","ENOG4110Q8P,-;ENOG410KIH2,-","-","-"]
["C12orf75",1.851712978,0.365016834,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000235162","F8VQD4,Chromosome 12 open reading frame 75","-","PF15506,OCC1 family","IPR029133,Overexpressed in colon carcinoma 1","ENOG41115A6,-;ENOG410JMVI,-","-","-"]
["IL17D",1.498846724,0.295458472,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000172458","G1QMG2,Interleukin 17D","XP_003279215.1,interleukin-17D","PF06083,Interleukin-17","IPR020440,Interleukin-17, chordata;IPR010345,Interleukin-17 family;IPR029034,Cystine-knot cytokine","ENOG410IHY3,-;ENOG4112BXJ,-","GO:1903707,biological_process,negative regulation of hemopoiesis;GO:0005125,molecular_function,cytokine activity;GO:0032725,biological_process,positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0042803,molecular_function,protein homodimerization activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0048018,molecular_function,receptor ligand activity;GO:0032757,biological_process,positive regulation of interleukin-8 production;GO:0006954,biological_process,inflammatory response;GO:1900017,biological_process,positive regulation of cytokine production involved in inflammatory response;GO:0032755,biological_process,positive regulation of interleukin-6 production;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space","K05492,ko04630,Jak-STAT signaling pathway"]
["HS6ST3",0.638824372,0.125927535,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000185352","I3ME25,Heparan-sulfate 6-O-sulfotransferase","XP_005317088.1,heparan-sulfate 6-O-sulfotransferase 3","PF03567,Sulfotransferase family","IPR010635,Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase;IPR005331,Sulfotransferase;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG3955,Heparan sulfate 6-O-sulfotransferase;ENOG410XSW4,-","GO:0008146,molecular_function,sulfotransferase activity;GO:0015015,biological_process,heparan sulfate proteoglycan biosynthetic process, enzymatic modification;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane;GO:0017095,molecular_function,heparan sulfate 6-O-sulfotransferase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["RASGRF1",0.502232153,0.099001947,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000058335","H2Q9X1,Uncharacterized protein","XP_001153395.2,ras-specific guanine nucleotide-releasing factor 1 isoform X4","PF00618,RasGEF N-terminal motif;PF00621,RhoGEF domain;PF00617,RasGEF domain;PF00169,PH domain","IPR000651,Ras-like guanine nucleotide exchange factor, N-terminal;IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR019804,Ras guanine-nucleotide exchange factor, conserved site;IPR035899,Dbl homology (DH) domain superfamily;IPR001849,Pleckstrin homology domain;IPR030745,Ras-specific guanine nucleotide-releasing factor 1;IPR001331,Guanine-nucleotide dissociation stimulator, CDC24, conserved site;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily;IPR000048,IQ motif, EF-hand binding site;IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain","ENOG410IQ6Q,-;ENOG410XPWA,-","GO:0035556,biological_process,intracellular signal transduction;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0046578,biological_process,regulation of Ras protein signal transduction;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005622,cellular_component,intracellular;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","-"]
["RTTN",0.551500006,0.108713817,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000176225","K7C2J4,Rotatin","-","PF14726,Rotatin, an armadillo repeat protein, centriole functioning","IPR011989,Armadillo-like helical;IPR030791,Rotatin;IPR016024,Armadillo-type fold;IPR029249,Rotatin, N-terminal","ENOG410XRDG,-;ENOG410IEI0,-","GO:0044782,biological_process,cilium organization;GO:0036064,cellular_component,ciliary basal body;GO:0005813,cellular_component,centrosome","-"]
["AC093110.3",4.034517032,0.795299624,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000238018","A0A1U7SE40,Spectrin beta chain","XP_008046159.1,spectrin beta chain, non-erythrocytic 1 isoform X1","-","IPR001715,Calponin homology domain;IPR002017,Spectrin repeat;IPR018159,Spectrin/alpha-actinin;IPR036872,CH domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR001589,Actinin-type actin-binding domain, conserved site;IPR016343,Spectrin, beta subunit;IPR001605,Pleckstrin homology domain, spectrin-type","-","GO:0051693,biological_process,actin filament capping;GO:0005737,cellular_component,cytoplasm;GO:0007010,biological_process,cytoskeleton organization;GO:0008091,cellular_component,spectrin;GO:0005856,cellular_component,cytoskeleton;GO:0003779,molecular_function,actin binding;GO:0005543,molecular_function,phospholipid binding;GO:0005200,molecular_function,structural constituent of cytoskeleton","-"]
["EML6",0.345671915,0.068140187,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000214595","G3QJZ3,Echinoderm microtubule associated protein like 6","XP_018876612.1,echinoderm microtubule-associated protein-like 6","PF12894,Anaphase-promoting complex subunit 4 WD40 domain;PF03451,HELP motif;PF00400,WD domain, G-beta repeat","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR024977,Anaphase-promoting complex subunit 4, WD40 domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR005108,HELP;IPR001680,WD40 repeat","-","-","-"]
["CHST10",1.111357934,0.219075181,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000115526","B7Z4E8,Carbohydrate sulfotransferase","-","PF03567,Sulfotransferase family","IPR018011,Carbohydrate sulfotransferase 8-10;IPR005331,Sulfotransferase","ENOG4111GJR,-;KOG4651,Chondroitin 6-sulfotransferase and related sulfotransferases","GO:0008146,molecular_function,sulfotransferase activity;GO:0005975,biological_process,carbohydrate metabolic process;GO:0005794,cellular_component,Golgi apparatus;GO:0016740,molecular_function,transferase activity;GO:0000139,cellular_component,Golgi membrane;GO:0016051,biological_process,carbohydrate biosynthetic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["AC006547.15",8.553452918,1.686089769,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000268292","A0A1D5R5N9,Uncharacterized protein","-","-","-","-","-","-"]
["STOX2",0.453910709,0.089476637,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000173320","H2QQH9,Uncharacterized protein","XP_526749.3,-","PF10264,Winged helix Storkhead-box1 domain","IPR019391,Storkhead-box protein, winged-helix domain","KOG3897,Conserved protein Knockout;ENOG410ZJ97,-","GO:0009792,biological_process,embryo development ending in birth or egg hatching;GO:0001893,biological_process,maternal placenta development","-"]
["GJA1",1.641970053,0.323671497,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000152661","H2QTN6,Gap junction protein","XP_001164338.3,-","PF00029,Connexin;PF03508,ap junction alpha-1 protein (Cx43)","IPR017990,Connexin, conserved site;IPR013124,Gap junction alpha-1 protein (Cx43), C-terminal;IPR035091,Gap junction alpha-1 protein (Cx43), alpha helix domain superfamily;IPR013092,Connexin, N-terminal;IPR002261,Gap junction alpha-1 protein (Cx43);IPR019570,Gap junction protein, cysteine-rich domain;IPR038359,Connexin, N-terminal domain superfamily;IPR000500,Connexin;IPR034634,Connexin, C-terminal","ENOG410IF97,-;ENOG4110JTW,-","GO:0030054,cellular_component,cell junction;GO:0007507,biological_process,heart development;GO:0005921,cellular_component,gap junction;GO:0005922,cellular_component,connexin complex;GO:0055085,biological_process,transmembrane transport;GO:0007267,biological_process,cell-cell signaling;GO:0007154,biological_process,cell communication;GO:0022857,molecular_function,transmembrane transporter activity;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K07372,ko04540,Gap junction;K07372,ko05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC)"]
["FAM185A",1.827285838,0.360201662,2.303096536,1.898428982,0.006647239,0.013208298,"ENSG00000222011","H2QV60,Uncharacterized protein","XP_001157204.1,protein FAM185A isoform X3","-","-","ENOG410IEWR,-;ENOG4110HBQ,-","-","-"]
["ZNF629",13.30276155,2.691501931,2.302827672,5.636769353,{"v":1.51e-15,"d":"1.51E-15"},5.28E-14,"ENSG00000102870","G3RKQ6,Zinc finger protein 629","XP_004057567.1,zinc finger protein 629 isoform X1","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["PPP2R5E",14.96402091,3.03127915,2.302078534,6.388430673,{"v":9.81e-19,"d":"9.81E-19"},{"v":6.32e-17,"d":"6.32E-17"},"ENSG00000154001","F1NLM6,Serine/threonine protein phosphatase 2A regulatory subunit","XP_015143376.1,-;XP_015143377.1,-","PF01603,Protein phosphatase 2A regulatory B subunit (B56 family)","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR002554,Protein phosphatase 2A, regulatory B subunit, B56","KOG2085,Serine/threonine protein phosphatase 2A, regulatory subunit;ENOG410XQJW,-","GO:0005829,cellular_component,cytosol;GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0000159,cellular_component,protein phosphatase type 2A complex;GO:0007165,biological_process,signal transduction;GO:0019888,molecular_function,protein phosphatase regulator activity","K11584,ko04113,Meiosis - yeast;K11584,ko03015,mRNA surveillance pathway;K11584,ko04114,Oocyte meiosis;K11584,ko04728,Dopaminergic synapse;K11584,ko04261,Adrenergic signaling in cardiomyocytes;K11584,ko04071,Sphingolipid signaling pathway;K11584,ko04152,AMPK signaling pathway;K11584,ko04151,PI3K-Akt signaling pathway"]
["PRKAB1",2.09098751,0.419677803,2.30180688,3.124187984,{"v":7.29e-06,"d":"7.29E-06"},{"v":2.87E-5,"d":"2.87E-05"},"ENSG00000111725","A0A0D9S4F8,Protein kinase AMP-activated non-catalytic subunit beta 1","XP_008003095.1,-","PF16561,lycogen recognition site of AMP-activated protein kinase;PF04739,5'-AMP-activated protein kinase beta subunit, interaction domain","IPR013783,Immunoglobulin-like fold;IPR032640,AMP-activated protein kinase, glycogen-binding domain;IPR006828,Association with the SNF1 complex (ASC) domain;IPR037256,ASC domain superfamily;IPR014756,Immunoglobulin E-set","-","GO:0035878,biological_process,nail development;GO:0006468,biological_process,protein phosphorylation;GO:0010628,biological_process,positive regulation of gene expression;GO:0005634,cellular_component,nucleus;GO:0004672,molecular_function,protein kinase activity","K07199,ko04211,Longevity regulating pathway;K07199,ko04068,FoxO signaling pathway;K07199,ko04910,Insulin signaling pathway;K07199,ko04931,Insulin resistance;K07199,ko04152,AMPK signaling pathway;K07199,ko04932,Non-alcoholic fatty liver disease (NAFLD);K07199,ko04921,Oxytocin signaling pathway;K07199,ko04213,Longevity regulating pathway - multiple species;K07199,ko04920,Adipocytokine signaling pathway;K07199,ko05410,Hypertrophic cardiomyopathy (HCM);K07199,ko04922,Glucagon signaling pathway;K07199,ko04710,Circadian rhythm"]
["DHX35",2.649149694,0.531705388,2.30180688,3.124187984,{"v":7.29e-06,"d":"7.29E-06"},{"v":2.87E-5,"d":"2.87E-05"},"ENSG00000101452","G3RDM2,Uncharacterized protein","XP_004062195.1,probable ATP-dependent RNA helicase DHX35","PF00271,Helicase conserved C-terminal domain;PF07717,Oligonucleotide/oligosaccharide-binding (OB)-fold;PF04408,Helicase associated domain (HA2)","IPR011709,Domain of unknown function DUF1605;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR007502,Helicase-associated domain;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR001650,Helicase, C-terminal","-","GO:0016787,molecular_function,hydrolase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004386,molecular_function,helicase activity","-"]
["CRISP3",9.405408514,1.895694164,2.301501146,3.769980052,{"v":1.26e-07,"d":"1.26E-07"},{"v":7.22e-07,"d":"7.22E-07"},"ENSG00000096006","J3KPA1,Cysteine-rich secretory protein 3","-","PF08562,Crisp;PF00188,Cysteine-rich secretory protein family","IPR001283,Cysteine-rich  secretory protein, allergen V5/Tpx-1-related;IPR034117,Cysteine-rich secretory protein, SCP domain;IPR003582,ShKT domain;IPR018244,Allergen V5/Tpx-1-related, conserved site;IPR013871,Cysteine-rich secretory protein;IPR014044,CAP domain;IPR035940,CAP superfamily","KOG3017,Defense-related protein containing SCP domain;COG2340,Uncharacterized protein with SCP/PR1 domains","GO:0016021,cellular_component,integral component of membrane;GO:0005576,cellular_component,extracellular region;GO:0016020,cellular_component,membrane","-"]
["MTRF1L",10.61429622,2.14710425,2.301236587,4.822531791,{"v":4.89e-12,"d":"4.89E-12"},{"v":7.5E-11,"d":"7.50E-11"},"ENSG00000112031","H2KNE8,Mitochondrial translational release factor 1-like, isoform CRA_a","-","PF00472,RF-1 domain;PF03462,PCRF domain","IPR005139,Peptide chain release factor;IPR000352,Peptide chain release factor class I/class II","COG0216,Protein chain release factor A;KOG2726,Mitochondrial polypeptide chain release factor","GO:0006415,biological_process,translational termination;GO:0003747,molecular_function,translation release factor activity","-"]
["YTHDF3",21.49971784,4.359630455,2.30056768,6.336058273,{"v":2.04e-18,"d":"2.04E-18"},{"v":1.27e-16,"d":"1.27E-16"},"ENSG00000185728","A0A087WY31,YTH domain-containing family protein 3","NP_001264742.1,YTH domain-containing family protein 3 isoform b;XP_011515811.1,-;NP_001264743.1,-","PF04146,YT521-B-like domain","IPR007275,YTH domain","-","GO:0003723,molecular_function,RNA binding","-"]
["AC090616.2",7.128259521,1.434424087,2.29593893,2.945616207,{"v":2.91e-05,"d":"2.91E-05"},{"v":9.94e-05,"d":"9.94E-05"},"ENSG00000214708","H2RBU7,Uncharacterized protein","-","-","-","-","-","-"]
["PARP3",3.892789267,0.7833484,2.29593893,2.945616207,{"v":2.91e-05,"d":"2.91E-05"},{"v":9.94e-05,"d":"9.94E-05"},"ENSG00000041880","Q59HF6,Poly [ADP-ribose] polymerase","-","PF05406,WGR domain;PF02877,Poly(ADP-ribose) polymerase, regulatory domain;PF00644,Poly(ADP-ribose) polymerase catalytic domain","IPR036616,Poly(ADP-ribose) polymerase, regulatory domain superfamily;IPR031275,Poly [ADP-ribose] polymerase 3;IPR004102,Poly(ADP-ribose) polymerase, regulatory domain;IPR036930,WGR domain superfamily;IPR008893,WGR domain;IPR012317,Poly(ADP-ribose) polymerase, catalytic domain","ENOG410XP18,-;KOG1037,NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins","GO:0006471,biological_process,protein ADP-ribosylation;GO:0006302,biological_process,double-strand break repair;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0003950,molecular_function,NAD+ ADP-ribosyltransferase activity;GO:0016740,molecular_function,transferase activity","-"]
["NCEH1",2.370650369,0.477047445,2.29593893,2.945616207,{"v":2.91e-05,"d":"2.91E-05"},{"v":9.94e-05,"d":"9.94E-05"},"ENSG00000144959","A0A0A0MTJ9,Neutral cholesterol ester hydrolase 1","NP_001139748.1,neutral cholesterol ester hydrolase 1 isoform a","PF07859,alpha/beta hydrolase fold","IPR033140,Lipase, GDXG, putative serine active site;IPR017157,Arylacetamide deacetylase;IPR002168,Lipase, GDXG, putative histidine active site;IPR013094,Alpha/beta hydrolase fold-3;IPR029058,Alpha/Beta hydrolase fold","COG0657,Esterase/lipase;KOG1515,Arylacetamide deacetylase","GO:0016787,molecular_function,hydrolase activity;GO:0060395,biological_process,SMAD protein signal transduction;GO:0006470,biological_process,protein dephosphorylation;GO:0017171,molecular_function,serine hydrolase activity;GO:0006805,biological_process,xenobiotic metabolic process;GO:0016020,cellular_component,membrane;GO:0042301,molecular_function,phosphate ion binding;GO:0052689,molecular_function,carboxylic ester hydrolase activity;GO:0008152,biological_process,metabolic process;GO:0016021,cellular_component,integral component of membrane","-"]
["VTA1",15.95711249,3.24865988,2.294608109,6.146309701,{"v":1.32e-17,"d":"1.32E-17"},{"v":6.91e-16,"d":"6.91E-16"},"ENSG00000009844","H2QTU7,Vps20-associated 1 homolog","XP_518771.1,-","PF04652,Vta1 like","IPR023175,Vacuolar protein sorting-associate protein Vta1/Callose synthase, N-terminal","KOG0917,Uncharacterized conserved protein;ENOG4111H3M,-","GO:0005737,cellular_component,cytoplasm;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0046755,biological_process,viral budding;GO:0071985,biological_process,multivesicular body sorting pathway;GO:0008022,molecular_function,protein C-terminus binding;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm","K12199,ko04144,Endocytosis"]
["PTPN13",9.152318152,1.863292548,2.294050465,5.738270836,{"v":7.98e-16,"d":"7.98E-16"},{"v":2.97e-14,"d":"2.97E-14"},"ENSG00000163629","K7C496,Protein tyrosine phosphatase, non-receptor type 13","XP_016807308.1,tyrosine-protein phosphatase non-receptor type 13 isoform X3","PF16599,Unstructured linker region on PTN13 protein between PDZ;PF00595,PDZ domain (Also known as DHR or GLGF);PF09380,RM C-terminal PH-like domain;PF09379,RM N-terminal domain;PF00102,Protein-tyrosine phosphatase;PF00373,RM central domain","IPR035963,FERM superfamily, second domain;IPR029021,Protein-tyrosine phosphatase-like;IPR036034,PDZ superfamily;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR018980,FERM, C-terminal PH-like domain;IPR011019,KIND domain;IPR001478,PDZ domain;IPR000299,FERM domain;IPR019748,FERM central domain;IPR000242,PTP type protein phosphatase;IPR011993,PH-like domain superfamily;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR000387,Tyrosine specific protein phosphatases domain;IPR029071,Ubiquitin-like domain superfamily;IPR012153,Tyrosine-protein phosphatase non-receptor type 13","KOG0792,Protein tyrosine phosphatase PTPMEG, contains FERM domain;COG5599,Protein tyrosine phosphatase","GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0006470,biological_process,protein dephosphorylation;GO:0030027,cellular_component,lamellipodium;GO:0005856,cellular_component,cytoskeleton;GO:0005886,cellular_component,plasma membrane;GO:0014066,biological_process,regulation of phosphatidylinositol 3-kinase signaling;GO:0016311,biological_process,dephosphorylation;GO:0036312,molecular_function,phosphatidylinositol 3-kinase regulatory subunit binding;GO:0005634,cellular_component,nucleus;GO:0016791,molecular_function,phosphatase activity","-"]
["AP4M1",9.554728421,1.942942919,2.293669126,4.816390872,{"v":6.11e-12,"d":"6.11E-12"},{"v":9.16e-11,"d":"9.16E-11"},"ENSG00000221838","C9JC87,AP-4 complex subunit mu-1","XP_005250746.1,AP-4 complex subunit mu-1 isoform X1;XP_011514987.1,-","PF00928,Adaptor complexes medium subunit family","IPR011012,Longin-like domain superfamily;IPR001392,Clathrin adaptor, mu subunit;IPR036168,AP-2 complex subunit mu, C-terminal superfamily;IPR018240,Clathrin adaptor, mu subunit, conserved site;IPR028565,Mu homology domain","KOG0937,Adaptor complexes medium subunit family;ENOG410XPFS,-","GO:0030131,cellular_component,clathrin adaptor complex;GO:0006886,biological_process,intracellular protein transport;GO:0015031,biological_process,protein transport;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport","-"]
["TGFBRAP1",4.033461252,0.818476549,2.292985911,3.956962028,{"v":1.53e-08,"d":"1.53E-08"},{"v":1.09E-7,"d":"1.09E-07"},"ENSG00000135966","K7AAY6,Transforming growth factor, beta receptor associated protein 1","-","PF10367,Vacuolar sorting protein 39 domain 2;PF00637,Region in Clathrin and VPS;PF10366,Vacuolar sorting protein 39 domain 1;PF00780,CNH domain","IPR019453,Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2;IPR000547,Clathrin, heavy chain/VPS, 7-fold repeat;IPR001180,Citron homology (CNH) domain;IPR032914,Vam6/VPS39/TRAP1 family;IPR019452,Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1","ENOG410XNSX,-;KOG2063,Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3","GO:0016192,biological_process,vesicle-mediated transport;GO:0006886,biological_process,intracellular protein transport;GO:0005622,cellular_component,intracellular","-"]
["HIVEP1",2.206114839,0.447668428,2.292985911,3.956962028,{"v":1.53e-08,"d":"1.53E-08"},{"v":1.09E-7,"d":"1.09E-07"},"ENSG00000095951","F5H212,Zinc finger protein 40","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR034729,Zinc finger CCHC HIVEP-type","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005654,cellular_component,nucleoplasm;GO:0016604,cellular_component,nuclear body;GO:0005739,cellular_component,mitochondrion","-"]
["NEDD9",12.5618457,2.562094705,2.292164502,6.31168798,{"v":3.65e-18,"d":"3.65E-18"},2.14E-16,"ENSG00000111859","K7CPX0,Neural cell expressed, developmentally down-regulated 9","-","PF14604,Variant SH3 domain;PF08824,Serine rich protein interaction domain;PF12026,omain of unknown function (DUF3513)","IPR021901,CAS family, C-terminal;IPR014928,Serine rich protein interaction domain;IPR037362,CAS family;IPR038319,CAS, serine rich four helix bundle domain superfamily;IPR035746,Enhancer of filamentation 1, SH3 domain;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain","ENOG410ZSUM,-;ENOG410IEDD,-","-","-"]
["PCLO",5.055877705,1.031424301,2.291649613,6.143878096,{"v":1.49e-17,"d":"1.49E-17"},{"v":7.68e-16,"d":"7.68E-16"},"ENSG00000186472","H2QUU9,Uncharacterized protein","XP_001160384.3,protein piccolo","PF00595,PDZ domain (Also known as DHR or GLGF);PF00168,C2 domain;PF05715,Piccolo Zn-finger","IPR011011,Zinc finger, FYVE/PHD-type;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR030629,Protein piccolo;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR008899,Zinc finger, piccolo-type","KOG2060,Rab3 effector RIM1 and related proteins, contain PDZ and C2 domains;ENOG410ZNB1,-","GO:0045202,cellular_component,synapse;GO:0048786,cellular_component,presynaptic active zone;GO:0046872,molecular_function,metal ion binding;GO:0007416,biological_process,synapse assembly","-"]
["ELK3",42.45468604,8.670956055,2.29068085,6.906055199,2.13E-20,1.89E-18,"ENSG00000111145","A0A024RBE2,ELK3, ETS-domain protein","NP_005221.2,ETS domain-containing protein Elk-3 isoform 1;XP_006719338.1,-","PF00178,ts-domain","IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000418,Ets domain","KOG3806,Predicted transcription factor;ENOG410Z0ZF,-","GO:0042060,biological_process,wound healing;GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0001525,biological_process,angiogenesis;GO:0005739,cellular_component,mitochondrion;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["UROS",3.395862382,0.690544668,2.289386218,3.860509188,{"v":5.85e-08,"d":"5.85E-08"},{"v":3.63e-07,"d":"3.63E-07"},"ENSG00000188690","A0A0S2Z4T8,Uroporphyrinogen III synthase isoform 1","NP_000366.1,uroporphyrinogen-III synthase isoform 2","PF02602,Uroporphyrinogen-III synthase HemD","IPR003754,Tetrapyrrole biosynthesis, uroporphyrinogen III synthase;IPR036108,Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily","-","GO:0071243,biological_process,cellular response to arsenic-containing substance;GO:0046677,biological_process,response to antibiotic;GO:0048037,molecular_function,cofactor binding;GO:0004852,molecular_function,uroporphyrinogen-III synthase activity;GO:0006779,biological_process,porphyrin-containing compound biosynthetic process;GO:0006780,biological_process,uroporphyrinogen III biosynthetic process;GO:0071418,biological_process,cellular response to amine stimulus;GO:0005739,cellular_component,mitochondrion;GO:0033014,biological_process,tetrapyrrole biosynthetic process;GO:0005829,cellular_component,cytosol;GO:0070541,biological_process,response to platinum ion","K01719,ko00860,Porphyrin and chlorophyll metabolism"]
["TGM5",6.212810191,1.263367731,2.289386218,3.860509188,{"v":5.85e-08,"d":"5.85E-08"},{"v":3.63e-07,"d":"3.63E-07"},"ENSG00000104055","A0A087WVS3,Protein-glutamine gamma-glutamyltransferase 5","-","PF01841,Transglutaminase-like superfamily;PF00927,Transglutaminase family, C-terminal ig like domain;PF00868,Transglutaminase family","IPR023608,Protein-glutamine gamma-glutamyltransferase, animal;IPR036238,Transglutaminase, C-terminal domain superfamily;IPR013808,Transglutaminase, active site;IPR036985,Transglutaminase-like superfamily;IPR002931,Transglutaminase-like;IPR014756,Immunoglobulin E-set;IPR008958,Transglutaminase, C-terminal;IPR001102,Transglutaminase, N-terminal;IPR013783,Immunoglobulin-like fold","ENOG410IFMV,-;ENOG410XQEZ,-","GO:0003810,molecular_function,protein-glutamine gamma-glutamyltransferase activity;GO:0046872,molecular_function,metal ion binding;GO:0018149,biological_process,peptide cross-linking","-"]
["DOPEY1",2.245765436,0.456673791,2.289386218,3.860509188,{"v":5.85e-08,"d":"5.85E-08"},{"v":3.63e-07,"d":"3.63E-07"},"ENSG00000083097","Q5TA12,Protein dopey-1","NP_001186871.1,protein dopey-1 isoform b;XP_016866050.1,-;XP_016866051.1,-","PF04118,opey, N-terminal","IPR007249,Dopey, N-terminal","KOG3613,Dopey and related predicted leucine zipper transcription factors;COG5221,Dopey and related predicted leucine zipper transcription factors","GO:0005829,cellular_component,cytosol;GO:0007029,biological_process,endoplasmic reticulum organization;GO:0000139,cellular_component,Golgi membrane;GO:0006895,biological_process,Golgi to endosome transport","-"]
["OPN3",2.619985457,0.529058307,2.288111593,2.741077486,0.000124562,0.00036903,"ENSG00000054277","H2Q1F0,Opsin 3","XP_016797203.1,-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR017452,GPCR, rhodopsin-like, 7TM;IPR027430,Visual pigments (opsins) retinal binding site;IPR000276,G protein-coupled receptor, rhodopsin-like","ENOG410XRW9,-;KOG3656,FOG: 7 transmembrane receptor","GO:0009584,biological_process,detection of visible light;GO:0018298,biological_process,protein-chromophore linkage;GO:0016020,cellular_component,membrane;GO:0009881,molecular_function,photoreceptor activity;GO:0008020,molecular_function,G-protein coupled photoreceptor activity;GO:0050896,biological_process,response to stimulus;GO:0004871,molecular_function,signal transducer activity;GO:0001750,cellular_component,photoreceptor outer segment;GO:0016021,cellular_component,integral component of membrane;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0007165,biological_process,signal transduction","-"]
["RP11-463I20.1",5.614686249,1.133783547,2.288111593,2.741077486,0.000124562,0.00036903,"ENSG00000279364","Q5R6A0,Uncharacterized protein DKFZp459M0519","-","-","-","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MARS2",3.22486451,0.651202607,2.288111593,2.741077486,0.000124562,0.00036903,"ENSG00000247626","K7AR51,Methionyl-tRNA synthetase 2, mitochondrial","-","PF09334,tRNA synthetases class I (M)","IPR015413,Methionyl/Leucyl tRNA synthetase;IPR014758,Methionyl-tRNA synthetase;IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR033911,Methioninyl-tRNA synthetase core domain;IPR009080,Aminoacyl-tRNA synthetase, class Ia, anticodon-binding","-","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0004825,molecular_function,methionine-tRNA ligase activity;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0006412,biological_process,translation;GO:0005737,cellular_component,cytoplasm;GO:0005759,cellular_component,mitochondrial matrix;GO:0016874,molecular_function,ligase activity;GO:0006431,biological_process,methionyl-tRNA aminoacylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0005739,cellular_component,mitochondrion","-"]
["MFSD6",46.97230199,9.616386964,2.287562749,7.42430446,7.95E-22,{"v":8.82e-20,"d":"8.82E-20"},"ENSG00000151690","H2QJ56,Major facilitator superfamily domain containing 6","XP_016805694.1,major facilitator superfamily domain-containing protein 6 isoform X1;XP_016805695.1,-","PF12832,MFS_1 like family","IPR024989,Major facilitator superfamily associated domain;IPR036259,MFS transporter superfamily;IPR020846,Major facilitator superfamily domain","ENOG410YMHR,-;KOG3762,Predicted transporter","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["IFIT3",12.77247751,2.606413768,2.287173523,4.412779302,{"v":4.73e-10,"d":"4.73E-10"},{"v":4.71e-09,"d":"4.71E-09"},"ENSG00000119917","Q5T765,Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_a","NP_001026853.1,-;NP_001540.2,interferon-induced protein with tetratricopeptide repeats 3 isoform a","PF13176,Tetratricopeptide repeat;PF13181,Tetratricopeptide repeat;PF13424,Tetratricopeptide repeat","IPR019734,Tetratricopeptide repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR024122,Interferon-induced protein with tetratricopeptide repeats 3;IPR013026,Tetratricopeptide repeat-containing domain","KOG1124,FOG: TPR repeat;COG0457,FOG: TPR repeat","GO:0035457,biological_process,cellular response to interferon-alpha;GO:0005829,cellular_component,cytosol;GO:0005739,cellular_component,mitochondrion","-"]
["FOXM1",44.39956993,9.096188718,2.286325968,7.046081551,1.11E-20,1.02E-18,"ENSG00000111206","G3R1V7,Forkhead box M1","XP_018893794.1,forkhead box protein M1 isoform X5","PF00250,orkhead domain","IPR018122,Fork head domain conserved site1;IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["RP11-385F5.4",6.729639745,1.326572652,2.283833002,1.424929782,0.041975388,0.067618611,"-","-","-","-","-","-","-","-"]
["DUSP8",0.720199747,0.141968564,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000184545","A0A0D9RC32,Dual specificity phosphatase 8","XP_007998546.1,dual specificity protein phosphatase 8 isoform X2","PF00581,Rhodanese-like domain;PF00782,ual specificity phosphatase, catalytic domain","IPR008343,Mitogen-activated protein (MAP) kinase phosphatase;IPR036873,Rhodanese-like domain superfamily;IPR029021,Protein-tyrosine phosphatase-like;IPR016130,Protein-tyrosine phosphatase, active site;IPR000340,Dual specificity phosphatase, catalytic domain;IPR001763,Rhodanese-like domain;IPR020422,Dual specificity protein phosphatase domain;IPR000387,Tyrosine specific protein phosphatases domain;IPR024950,Dual specificity phosphatase","-","GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0000188,biological_process,inactivation of MAPK activity;GO:0006470,biological_process,protein dephosphorylation;GO:0017017,molecular_function,MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","-"]
["RP11-1038A11.3",2.072594784,0.408557912,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000256417","O95662,KpnI repetitive sequence","-","-","-","-","GO:0005575,cellular_component,cellular_component;GO:0008150,biological_process,biological_process;GO:0003674,molecular_function,molecular_function","-"]
["RP11-575F12.3",1.133461314,0.223432284,2.283833002,1.424929782,0.041975388,0.067618611,"-","-","-","-","-","-","-","-"]
["FOXB1",0.919624352,0.181279914,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000171956","G3GRN3,Forkhead box protein B1","XP_007647473.1,-;XP_007608087.1,-","PF00250,orkhead domain","IPR018122,Fork head domain conserved site1;IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily","-","GO:0021794,biological_process,thalamus development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0007412,biological_process,axon target recognition;GO:0007595,biological_process,lactation;GO:0005634,cellular_component,nucleus;GO:0061379,biological_process,inferior colliculus development;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0021767,biological_process,mammillary body development;GO:0008542,biological_process,visual learning;GO:0021510,biological_process,spinal cord development;GO:0030901,biological_process,midbrain development;GO:0061377,biological_process,mammary gland lobule development;GO:0033504,biological_process,floor plate development;GO:0003677,molecular_function,DNA binding;GO:0001655,biological_process,urogenital system development;GO:0061374,biological_process,mammillothalamic axonal tract development;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0061381,biological_process,cell migration in diencephalon;GO:0001756,biological_process,somitogenesis;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0021855,biological_process,hypothalamus cell migration;GO:0061030,biological_process,epithelial cell differentiation involved in mammary gland alveolus development;GO:0022029,biological_process,telencephalon cell migration","-"]
["CTD-2270L9.4",3.301332705,0.65077149,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000260136","H2NQE4,Component of oligomeric golgi complex 7","-","PF10191,olgi complex component 7 (COG7)","IPR019335,Conserved oligomeric Golgi complex subunit 7","ENOG410XT6U,-;KOG4182,Uncharacterized conserved protein","GO:0005794,cellular_component,Golgi apparatus;GO:0050821,biological_process,protein stabilization;GO:0005730,cellular_component,nucleolus;GO:0033365,biological_process,protein localization to organelle;GO:0006486,biological_process,protein glycosylation;GO:0034067,biological_process,protein localization to Golgi apparatus;GO:0006890,biological_process,retrograde vesicle-mediated transport, Golgi to ER;GO:0017119,cellular_component,Golgi transport complex;GO:0006886,biological_process,intracellular protein transport","-"]
["RP11-46C24.6",8.249235816,1.626121316,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000260659","A0A0A0MSW5,Zinc finger protein 778","XP_011521242.1,-;XP_005256345.1,-;NP_001188336.1,zinc finger protein 778 isoform 1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13465,Zinc-finger double domain","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["RP11-81A22.4",1.578557471,0.311171363,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000280254","I7GC03,Macaca fascicularis brain cDNA clone: QflA-17923, similar to human protocadherin 11 X-linked","-","-","-","-","-","-"]
["TNFSF13",1.460651157,0.287929214,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000161955","Q6FGN4,HCG2045906, isoform CRA_d","-","PF00229,TNF(Tumour Necrosis Factor) family","IPR008983,Tumour necrosis factor-like domain superfamily;IPR006052,Tumour necrosis factor domain;IPR021184,Tumour necrosis factor, conserved site","ENOG410Y4KC,-;ENOG410II60,-","GO:0005164,molecular_function,tumor necrosis factor receptor binding;GO:0005125,molecular_function,cytokine activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0006955,biological_process,immune response;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space","-"]
["RP11-597M12.1",9.923707564,1.956199672,2.283833002,1.424929782,0.041975388,0.067618611,"-","-","-","-","-","-","-","-"]
["RP11-74H8.1",14.51721412,2.861689477,2.283833002,1.424929782,0.041975388,0.067618611,"-","-","-","-","-","-","-","-"]
["ZNF181",0.530552511,0.104584566,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000197841","F8W889,Zinc finger protein 181","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily;IPR003656,Zinc finger, BED-type","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["CTD-2331H12.8",1.690967464,0.333330056,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000283088","A0A0U1RQK1,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["RP11-734K21.5",1.01571709,0.200222087,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000261104","H2PFS9,Uncharacterized protein","-","-","-","-","-","-"]
["AC012363.4",5.78163832,1.139698939,2.283833002,1.424929782,0.041975388,0.067618611,"-","-","-","-","-","-","-","-"]
["RP11-363J17.1",7.785578534,1.534723396,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000256458","H2P8C8,Uncharacterized protein","-","-","-","-","-","-"]
["RP5-1125A11.7",0.985603923,0.194286063,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000276073","Q9NX85,cDNA FLJ20378 fis, clone KAIA0536","-","-","-","-","-","-"]
["KB-1572G7.2",1.063481137,0.209637521,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000273000","A0A0D9RGC7,Uncharacterized protein","-","-","IPR008979,Galactose-binding-like domain superfamily","-","-","-"]
["TUG1_4",18.36708306,3.620590553,2.283833002,1.424929782,0.041975388,0.067618611,"-","-","-","-","-","-","-","-"]
["RPL39P5",7.404102526,1.459525368,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000214289","G7PAR7,Uncharacterized protein","-","PF00832,Ribosomal L39 protein","IPR023626,Ribosomal protein L39e domain superfamily;IPR020083,Ribosomal protein L39e, conserved site;IPR000077,Ribosomal protein L39e","-","GO:0005840,cellular_component,ribosome;GO:0006412,biological_process,translation;GO:0003735,molecular_function,structural constituent of ribosome;GO:0005622,cellular_component,intracellular","-"]
["PLSCR4",0.786477888,0.155033568,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000114698","B2R720,Phospholipid scramblase","-","PF03803,Scramblase","IPR005552,Scramblase","KOG0621,Phospholipid scramblase;ENOG410XSYS,-","-","-"]
["RP11-115C21.2",1.133074995,0.223356132,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000246089","H2PG84,Uncharacterized protein","-","-","-","-","-","-"]
["MCPH1-AS1",1.091412355,0.215143431,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000249898","L0BF26,Microcephalin","-","PF16589,BRCT domain, a BRCA1 C-terminus domain;PF12738,twin BRCT domain;PF12258,Microcephalin protein","IPR036420,BRCT domain superfamily;IPR029504,Microcephalin, mammal;IPR022047,Microcephalin-like;IPR001357,BRCT domain","ENOG41120NI,-;KOG4362,Transcriptional regulator BRCA1","GO:0021987,biological_process,cerebral cortex development","-"]
["DNM1",0.308532903,0.060819201,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000106976","H2R2B8,Dynamin 1","XP_016817262.1,-;XP_003312333.1,-","PF00350,ynamin family;PF01031,ynamin central region;PF02212,ynamin GTPase effector domain;PF00169,PH domain","IPR019762,Dynamin, GTPase region, conserved site;IPR000375,Dynamin central domain;IPR020850,GTPase effector domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR027741,Dynamin-1;IPR030381,Dynamin-type guanine nucleotide-binding (G) domain;IPR011993,PH-like domain superfamily;IPR022812,Dynamin superfamily;IPR003130,Dynamin GTPase effector;IPR001849,Pleckstrin homology domain;IPR001401,Dynamin, GTPase domain","KOG0446,Vacuolar sorting protein VPS1, dynamin, and related proteins;COG0699,Predicted GTPases (dynamin-related)","GO:0003374,biological_process,dynamin family protein polymerization involved in mitochondrial fission;GO:0061025,biological_process,membrane fusion;GO:0005525,molecular_function,GTP binding;GO:0031966,cellular_component,mitochondrial membrane;GO:0072583,biological_process,clathrin-dependent endocytosis;GO:0000266,biological_process,mitochondrial fission;GO:0008017,molecular_function,microtubule binding;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding","K01528,ko04721,Synaptic vesicle cycle;K01528,ko05100,Bacterial invasion of epithelial cells;K01528,ko04961,Endocrine and other factor-regulated calcium reabsorption;K01528,ko04072,Phospholipase D signaling pathway;K01528,ko04144,Endocytosis"]
["ZNF674",0.535941002,0.105646766,2.283833002,1.424929782,0.041975388,0.067618611,"ENSG00000251192","G3RBM3,Zinc finger protein 674","XP_004064096.1,zinc finger protein 674 isoform X1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TMEM201",2.079395473,0.423337784,2.282965555,3.264339931,{"v":6.58e-06,"d":"6.58E-06"},{"v":2.6e-05,"d":"2.60E-05"},"ENSG00000188807","K7CX57,Transmembrane protein 201","XP_016809144.1,-","PF09779,Ima1 N-terminal domain;PF10476,Protein of unknown function C-terminus (DUF2448)","IPR018861,Transmembrane protein 201;IPR018617,Ima1, N-terminal domain","-","GO:0005521,molecular_function,lamin binding;GO:0007097,biological_process,nuclear migration;GO:0016020,cellular_component,membrane;GO:0031965,cellular_component,nuclear membrane;GO:0005639,cellular_component,integral component of nuclear inner membrane;GO:0051015,molecular_function,actin filament binding;GO:0010761,biological_process,fibroblast migration;GO:0016021,cellular_component,integral component of membrane","-"]
["NLGN2",2.609922318,0.531346127,2.282965555,3.264339931,{"v":6.58e-06,"d":"6.58E-06"},{"v":2.6e-05,"d":"2.60E-05"},"ENSG00000169992","A0A0D9RH57,Neuroligin 2","XP_008008327.1,-","PF07859,alpha/beta hydrolase fold;PF00135,Carboxylesterase family","IPR030023,Neuroligin-2;IPR019819,Carboxylesterase type B, conserved site;IPR029058,Alpha/Beta hydrolase fold;IPR002018,Carboxylesterase, type B;IPR000460,Neuroligin","-","GO:0097105,biological_process,presynaptic membrane assembly;GO:0060077,cellular_component,inhibitory synapse;GO:0050804,biological_process,modulation of chemical synaptic transmission;GO:0045202,cellular_component,synapse;GO:2000809,biological_process,positive regulation of synaptic vesicle clustering;GO:0097151,biological_process,positive regulation of inhibitory postsynaptic potential;GO:0050839,molecular_function,cell adhesion molecule binding;GO:0007155,biological_process,cell adhesion;GO:0019233,biological_process,sensory perception of pain;GO:0002087,biological_process,regulation of respiratory gaseous exchange by neurological system process;GO:0097119,biological_process,postsynaptic density protein 95 clustering;GO:2000311,biological_process,regulation of AMPA receptor activity;GO:0050808,biological_process,synapse organization;GO:2000463,biological_process,positive regulation of excitatory postsynaptic potential;GO:0032230,biological_process,positive regulation of synaptic transmission, GABAergic;GO:0051968,biological_process,positive regulation of synaptic transmission, glutamatergic;GO:0042802,molecular_function,identical protein binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0035641,biological_process,locomotory exploration behavior;GO:0097116,biological_process,gephyrin clustering involved in postsynaptic density assembly;GO:0016020,cellular_component,membrane;GO:0050885,biological_process,neuromuscular process controlling balance;GO:0035418,biological_process,protein localization to synapse;GO:0032024,biological_process,positive regulation of insulin secretion;GO:0042043,molecular_function,neurexin family protein binding;GO:1904862,biological_process,inhibitory synapse assembly;GO:0097104,biological_process,postsynaptic membrane assembly;GO:1902474,biological_process,positive regulation of protein localization to synapse","K07378,ko04514,Cell adhesion molecules (CAMs)"]
["ZNF558",1.769925325,0.360333701,2.282965555,3.264339931,{"v":6.58e-06,"d":"6.58E-06"},{"v":2.6e-05,"d":"2.60E-05"},"ENSG00000167785","G3QUT9,Zinc finger protein 558","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","-","-","-","-"]
["UBE2D1",7.356768701,1.503905657,2.282852135,4.036674169,{"v":7.6e-09,"d":"7.60E-09"},{"v":5.75e-08,"d":"5.75E-08"},"ENSG00000072401","A0A218UXC3,Ubiquitin-conjugating enzyme E2 D1","-","-","IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR023313,Ubiquitin-conjugating enzyme, active site;IPR000608,Ubiquitin-conjugating enzyme E2","-","GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["CNTN1",3.423077375,0.699761762,2.282852135,4.036674169,{"v":7.6e-09,"d":"7.60E-09"},{"v":5.75e-08,"d":"5.75E-08"},"ENSG00000018236","A0A024R104,Contactin 1, isoform CRA_a","XP_011536228.1,-;NP_001834.2,contactin-1 isoform 1 precursor;XP_006719304.1,-;XP_005268708.1,-;XP_011536229.1,-","PF13927,Immunoglobulin domain;PF00041,ibronectin type III domain;PF07679,Immunoglobulin I-set domain","IPR036992,Contactin-1;IPR003961,Fibronectin type III;IPR007110,Immunoglobulin-like domain;IPR036116,Fibronectin type III superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","KOG3513,Neural cell adhesion molecule L1;ENOG410XSVG,-","GO:0021549,biological_process,cerebellum development;GO:0043209,cellular_component,myelin sheath;GO:0010628,biological_process,positive regulation of gene expression;GO:0010765,biological_process,positive regulation of sodium ion transport;GO:0045121,cellular_component,membrane raft;GO:0007399,biological_process,nervous system development;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0030246,molecular_function,carbohydrate binding;GO:0010976,biological_process,positive regulation of neuron projection development;GO:0031175,biological_process,neuron projection development","K06759,ko04514,Cell adhesion molecules (CAMs)"]
["BUD13",21.84287311,4.476276572,2.282783525,4.903640766,{"v":3.83e-12,"d":"3.83E-12"},{"v":6.05e-11,"d":"6.05E-11"},"ENSG00000137656","H2Q4T9,BUD13 homolog","XP_001152604.1,BUD13 homolog","PF09736,Pre-mRNA-splicing factor of RES complex","IPR018609,Bud13","KOG2654,Uncharacterized conserved protein;ENOG410XSEZ,-","GO:0005634,cellular_component,nucleus","-"]
["RP11-138C9.1",346.8518976,71.17782702,2.282745489,5.830063782,{"v":3.16e-16,"d":"3.16E-16"},1.26E-14,"-","-","-","-","-","-","-","-"]
["MAST4",2.831722346,0.58052808,2.281619363,4.703653125,{"v":3.11e-11,"d":"3.11E-11"},{"v":4e-10,"d":"4.00E-10"},"ENSG00000069020","J3QT34,Microtubule-associated serine/threonine-protein kinase 4","-","PF00069,Protein kinase domain;PF08926,omain of unknown function (DUF1908);PF00595,PDZ domain (Also known as DHR or GLGF)","IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR015022,Microtubule-associated serine/threonine-protein kinase, domain;IPR037711,Microtubule-associated serine/threonine-protein kinase, catalytic domain;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR008271,Serine/threonine-protein kinase, active site;IPR023142,Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily;IPR000719,Protein kinase domain","-","GO:0016301,molecular_function,kinase activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0000287,molecular_function,magnesium ion binding","-"]
["AHI1",3.491659804,0.715175813,2.281221535,4.270370116,{"v":1.3e-09,"d":"1.30E-09"},{"v":1.16E-8,"d":"1.16E-08"},"ENSG00000135541","K7C450,Abelson helper integration site 1","XP_527511.3,-;XP_001170641.1,jouberin isoform X2","PF00018,SH3 domain;PF00400,WD domain, G-beta repeat","IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain;IPR035832,Jouberin, SH3 domain;IPR001680,WD40 repeat","ENOG410XVKN,-;ENOG410IQ0Z,-","GO:0005911,cellular_component,cell-cell junction;GO:0005912,cellular_component,adherens junction;GO:0005929,cellular_component,cilium;GO:0036064,cellular_component,ciliary basal body;GO:0005813,cellular_component,centrosome;GO:0042802,molecular_function,identical protein binding","-"]
["SLC38A1",25.29904893,5.202045708,2.281175304,7.265417222,{"v":2.8E-21,"d":"2.80E-21"},{"v":2.89e-19,"d":"2.89E-19"},"ENSG00000111371","F8VX04,Sodium-coupled neutral amino acid transporter 1","NP_001265319.1,sodium-coupled neutral amino acid transporter 1 isoform 2","PF01490,Transmembrane amino acid transporter protein","IPR013057,Amino acid transporter, transmembrane domain","COG0814,Amino acid permeases;KOG1305,Amino acid transporter protein","GO:0007565,biological_process,female pregnancy;GO:0015186,molecular_function,L-glutamine transmembrane transporter activity;GO:0030424,cellular_component,axon;GO:0006868,biological_process,glutamine transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["FN1",3.593101823,0.738023353,2.280408674,5.268726524,1.19E-13,{"v":2.67e-12,"d":"2.67E-12"},"ENSG00000115414","H2R1A9,Uncharacterized protein","XP_516072.3,fibronectin isoform X2","PF00041,ibronectin type III domain;PF00040,ibronectin type II domain;PF00039,ibronectin type I domain","IPR000562,Fibronectin type II domain;IPR003961,Fibronectin type III;IPR000083,Fibronectin, type I;IPR036116,Fibronectin type III superfamily;IPR013806,Kringle-like fold;IPR013783,Immunoglobulin-like fold;IPR036943,Fibronectin type II domain superfamily","ENOG410IF4N,-;ENOG410Y2NH,-","GO:0045773,biological_process,positive regulation of axon extension;GO:0005578,,;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0033622,biological_process,integrin activation;GO:0007044,biological_process,cell-substrate junction assembly;GO:0005102,molecular_function,signaling receptor binding;GO:0051087,molecular_function,chaperone binding;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:2001202,biological_process,negative regulation of transforming growth factor-beta secretion;GO:0007155,biological_process,cell adhesion;GO:0048146,biological_process,positive regulation of fibroblast proliferation;GO:0007160,biological_process,cell-matrix adhesion;GO:0031012,cellular_component,extracellular matrix;GO:0002020,molecular_function,protease binding;GO:0070372,biological_process,regulation of ERK1 and ERK2 cascade;GO:0005605,cellular_component,basal lamina;GO:0010952,biological_process,positive regulation of peptidase activity;GO:0042802,molecular_function,identical protein binding;GO:0042060,biological_process,wound healing;GO:0010628,biological_process,positive regulation of gene expression;GO:0051702,biological_process,interaction with symbiont;GO:0005793,cellular_component,endoplasmic reticulum-Golgi intermediate compartment;GO:0097718,molecular_function,disordered domain specific binding;GO:0016324,cellular_component,apical plasma membrane;GO:0016504,molecular_function,peptidase activator activity;GO:0008022,molecular_function,protein C-terminus binding;GO:0034446,biological_process,substrate adhesion-dependent cell spreading;GO:0019899,molecular_function,enzyme binding;GO:0052047,biological_process,interaction with other organism via secreted substance involved in symbiotic interaction;GO:0070062,cellular_component,extracellular exosome;GO:0035987,biological_process,endodermal cell differentiation;GO:0005604,cellular_component,basement membrane;GO:1904237,biological_process,positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:0005577,cellular_component,fibrinogen complex;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0005178,molecular_function,integrin binding;GO:0007161,biological_process,calcium-independent cell-matrix adhesion;GO:0018149,biological_process,peptide cross-linking","-"]
["CTBP2",22.69169669,4.669787816,2.279964332,7.237146823,{"v":3.14e-21,"d":"3.14E-21"},{"v":3.17e-19,"d":"3.17E-19"},"ENSG00000175029","G3QWI9,C-terminal binding protein 2","-","PF00389,-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain;PF02826,-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain","IPR036291,NAD(P)-binding domain superfamily;IPR029753,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site;IPR006140,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain;IPR006139,D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain","-","GO:0051287,molecular_function,NAD binding;GO:0019901,molecular_function,protein kinase binding;GO:0048386,biological_process,positive regulation of retinoic acid receptor signaling pathway;GO:0050872,biological_process,white fat cell differentiation;GO:0017053,cellular_component,transcriptional repressor complex;GO:0003713,molecular_function,transcription coactivator activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0044877,molecular_function,protein-containing complex binding;GO:0035563,biological_process,positive regulation of chromatin binding;GO:0003714,molecular_function,transcription corepressor activity;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0042974,molecular_function,retinoic acid receptor binding;GO:0008152,biological_process,metabolic process;GO:0016616,molecular_function,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0055114,biological_process,oxidation-reduction process;GO:0045202,cellular_component,synapse;GO:0097470,cellular_component,ribbon synapse;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["GID4",12.85292917,2.641432763,2.279842092,5.372367639,{"v":3.1E-14,"d":"3.10E-14"},{"v":7.89e-13,"d":"7.89E-13"},"ENSG00000141034","K4DI96,Glucose-induced degradation protein 4 homolog","XP_005256856.1,glucose-induced degradation protein 4 homolog isoform X1","PF09783,Vacuolar import and degradation protein","IPR018618,Vacuolar import/degradation protein Vid24","-","-","-"]
["RP11-513I15.6",13.06646872,2.688682788,2.279129377,6.052474084,{"v":4.09e-17,"d":"4.09E-17"},{"v":1.95e-15,"d":"1.95E-15"},"ENSG00000225339","F7I2P6,Latent transforming growth factor beta binding protein 4","-","-","-","-","-","-"]
["RP11-284F21.9",7.443660668,1.525435033,2.278792322,3.945635603,{"v":2.07E-8,"d":"2.07E-08"},{"v":1.41e-07,"d":"1.41E-07"},"ENSG00000272068","G7NBQ1,Uncharacterized protein","-","-","-","-","-","-"]
["UBE3B",3.584879733,0.736736245,2.278414069,4.804028463,9.53E-12,{"v":1.38e-10,"d":"1.38E-10"},"ENSG00000151148","A0A024RBI2,Ubiquitin protein ligase E3B, isoform CRA_a","NP_569733.2,-;XP_011537261.1,-;XP_005254044.1,-;NP_904324.1,ubiquitin-protein ligase E3B isoform 1","PF00632,HECT-domain (ubiquitin-transferase)","IPR000569,HECT domain;IPR035983,HECT, E3 ligase catalytic domain;IPR000048,IQ motif, EF-hand binding site","KOG0942,E3 ubiquitin protein ligase;COG5021,Ubiquitin-protein ligase","GO:0016874,molecular_function,ligase activity;GO:0016567,biological_process,protein ubiquitination;GO:0016740,molecular_function,transferase activity;GO:0004842,molecular_function,ubiquitin-protein transferase activity","K10588,ko04120,Ubiquitin mediated proteolysis"]
["BACH1",5.784956241,1.18887864,2.278414069,4.804028463,9.53E-12,{"v":1.38e-10,"d":"1.38E-10"},"ENSG00000156273","A8K4Q6,cDNA FLJ77930, highly similar to Homo sapiens BTB and CNC homology 1, basic leucine zipper transcription factor 1, transcript variant 2, mRNA","-","PF03131,bZIP Maf transcription factor;PF00651,BTB/POZ domain","IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily;IPR008917,Transcription factor, Skn-1-like, DNA-binding domain superfamily;IPR004826,Basic leucine zipper domain, Maf-type;IPR004827,Basic-leucine zipper domain","ENOG410Z743,-;ENOG410ISV2,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0006351,biological_process,transcription, DNA-templated","-"]
["NDRG1",6.647820417,1.367627125,2.278275046,5.337220127,{"v":5.1e-14,"d":"5.10E-14"},1.23E-12,"ENSG00000104419","H2QWR4,Uncharacterized protein","XP_009454233.1,-;XP_009454234.1,-","PF03096,Ndr family","IPR004142,NDRG;IPR030693,Protein NDRG1;IPR029058,Alpha/Beta hydrolase fold","ENOG410XSPF,-;KOG2931,Differentiation-related gene 1 protein (NDR1 protein), related proteins","GO:0005886,cellular_component,plasma membrane;GO:0008017,molecular_function,microtubule binding;GO:0005634,cellular_component,nucleus;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0090232,biological_process,positive regulation of spindle checkpoint;GO:0017137,molecular_function,Rab GTPase binding;GO:0005737,cellular_component,cytoplasm;GO:0005913,cellular_component,cell-cell adherens junction;GO:0030330,biological_process,DNA damage response, signal transduction by p53 class mediator;GO:0005813,cellular_component,centrosome;GO:0055038,cellular_component,recycling endosome membrane;GO:0005829,cellular_component,cytosol;GO:0042127,biological_process,regulation of cell proliferation;GO:0032287,biological_process,peripheral nervous system myelin maintenance;GO:0045576,biological_process,mast cell activation;GO:0043015,molecular_function,gamma-tubulin binding;GO:0071456,biological_process,cellular response to hypoxia;GO:0007165,biological_process,signal transduction;GO:0043209,cellular_component,myelin sheath;GO:0005874,cellular_component,microtubule;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0045296,molecular_function,cadherin binding","-"]
["RIC1",3.344509088,0.686525668,2.277741058,4.193462472,{"v":3.21e-09,"d":"3.21E-09"},{"v":2.63e-08,"d":"2.63E-08"},"ENSG00000107036","K7DJT4,KIAA1432","XP_016816051.1,RAB6A-GEF complex partner protein 1 isoform X1","PF07064,RIC1","IPR009771,Ribosome control protein 1;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR036322,WD40-repeat-containing domain superfamily","ENOG410XT5J,-;KOG2006,WD40 repeat protein","GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0032991,cellular_component,protein-containing complex;GO:0017137,molecular_function,Rab GTPase binding;GO:0034066,cellular_component,RIC1-RGP1 guanyl-nucleotide exchange factor complex;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0016020,cellular_component,membrane;GO:1903363,biological_process,negative regulation of cellular protein catabolic process;GO:0005829,cellular_component,cytosol;GO:0017112,molecular_function,Rab guanyl-nucleotide exchange factor activity","-"]
["RP11-158M2.2",14.18918267,2.879292136,2.277146577,2.50162386,0.00057344,0.001464589,"ENSG00000259544","K7DTA8,A kinase","XP_001163906.1,A-kinase anchor protein 13 isoform X14","PF00621,RhoGEF domain;PF00169,PH domain","IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR028852,A-kinase anchor protein 13;IPR035899,Dbl homology (DH) domain superfamily;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR000219,Dbl homology (DH) domain","ENOG410XT68,-;ENOG410IR0Y,-","GO:0016301,molecular_function,kinase activity;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0035556,biological_process,intracellular signal transduction;GO:0046872,molecular_function,metal ion binding;GO:0065009,biological_process,regulation of molecular function;GO:0004691,molecular_function,cAMP-dependent protein kinase activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005622,cellular_component,intracellular;GO:0006468,biological_process,protein phosphorylation;GO:0016310,biological_process,phosphorylation","-"]
["C16orf45",2.189166198,0.444229183,2.277146577,2.50162386,0.00057344,0.001464589,"ENSG00000166780","A0A024QZI8,Chromosome 16 open reading frame 45, isoform CRA_a","NP_149978.1,uncharacterized protein C16orf45 isoform 1","PF12130,Protein of unknown function (DUF3585)","IPR022735,Domain of unknown function DUF3585","ENOG4111I1T,-;ENOG410IDZ0,-","GO:0007026,biological_process,negative regulation of microtubule depolymerization;GO:0021822,biological_process,negative regulation of cell motility involved in cerebral cortex radial glia guided migration;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["RP11-361L15.3",18.47516004,3.749009669,2.277146577,2.50162386,0.00057344,0.001464589,"-","-","-","-","-","-","-","-"]
["CTD-2033A16.1",14.04112163,2.849247349,2.277146577,2.50162386,0.00057344,0.001464589,"ENSG00000261602","G7NIM6,Uncharacterized protein","-","-","-","-","-","-"]
["ZNF426",1.070065598,0.21713946,2.277146577,2.50162386,0.00057344,0.001464589,"ENSG00000130818","A0A024R7D7,Zinc finger protein 426, isoform CRA_b","NP_077011.1,zinc finger protein 426 isoform 1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily;IPR003656,Zinc finger, BED-type","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["PCDHGC3",1.48631166,0.301604791,2.277146577,2.50162386,0.00057344,0.001464589,"ENSG00000240184","K7C9Y1,Protocadherin gamma subfamily C, 3","NP_001076040.1,protocadherin gamma-C3 precursor","PF08266,Cadherin-like;PF00028,Cadherin domain;PF15974,Cadherin C-terminal cytoplasmic tail, catenin-binding region;PF16492,Cadherin cytoplasmic C-terminal","IPR002126,Cadherin;IPR013164,Cadherin, N-terminal;IPR032455,Cadherin, cytoplasmic C-terminal domain;IPR031904,Cadherin, C-terminal catenin-binding domain;IPR015919,Cadherin-like;IPR030728,Protocadherin gamma-C3;IPR020894,Cadherin conserved site","-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["CAPRIN1",58.46170569,12.05992391,2.276846164,8.088787537,{"v":3.71e-23,"d":"3.71E-23"},{"v":4.94e-21,"d":"4.94E-21"},"ENSG00000135387","K7C550,Cell cycle associated protein 1","XP_016776149.1,-","PF12287,Cytoplasmic activation/proliferation-associated protein-1 C term","IPR022070,Cytoplasmic activation/proliferation-associated protein-1 C term;IPR028816,Caprin","ENOG4110M5Q,-;ENOG410IEA8,-","-","-"]
["CCDC6",57.5141727,11.86636847,2.276586937,7.999597434,{"v":5.62e-23,"d":"5.62E-23"},7.18E-21,"ENSG00000108091","H2QZY4,Coiled-coil domain containing 6","XP_521482.2,-","PF09755,Uncharacterized conserved protein H4 (DUF2046)","IPR019152,Protein of unknown function DUF2046","ENOG410XR5H,-;KOG2129,Uncharacterized conserved protein H4","GO:0005829,cellular_component,cytosol","K09288,ko05200,Pathways in cancer;K09288,ko05216,Thyroid cancer"]
["NTAN1",10.79974107,2.221447085,2.27642246,4.588516034,{"v":7.06e-11,"d":"7.06E-11"},{"v":8.32e-10,"d":"8.32E-10"},"ENSG00000157045","H2QAM3,N-terminal asparagine amidase","XP_510838.2,protein N-terminal asparagine amidohydrolase isoform X1;XP_016784970.1,-","PF14736,Protein N-terminal asparagine amidohydrolase","IPR026750,Protein N-terminal asparagine amidohydrolase","ENOG410IE4U,-;ENOG410XW2S,-","GO:0008418,molecular_function,protein-N-terminal asparagine amidohydrolase activity","-"]
["ZNF532",3.198986143,0.65801378,2.27642246,4.588516034,{"v":7.06e-11,"d":"7.06E-11"},{"v":8.32e-10,"d":"8.32E-10"},"ENSG00000074657","A0A024R283,Zinc finger protein 532, isoform CRA_a","XP_016881301.1,-;XP_016881304.1,-;XP_016881302.1,-;NP_001305655.1,-;XP_016881307.1,-;XP_016881306.1,-;XP_016881303.1,-;NP_001305656.1,-;NP_001305657.1,-;XP_016881305.1,-;NP_060651.2,zinc finger protein 532 isoform a","PF13912,C2H2-type zinc finger;PF16622,zinc-finger C2H2-type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["PLEKHM3",1.098693158,0.224600082,2.275404893,3.103622467,{"v":1.06E-5,"d":"1.06E-05"},{"v":4.01e-05,"d":"4.01E-05"},"ENSG00000178385","K7DFS6,Pleckstrin homology domain containing, family M, member 3","-","PF13901,Putative zinc-RING and/or ribbon;PF00169,PH domain","IPR011993,PH-like domain superfamily;IPR037812,PLEKHM3, PH domain 1;IPR001849,Pleckstrin homology domain;IPR025258,Putative zinc-RING and/or ribbon","ENOG410ZMB5,-;KOG1829,Uncharacterized conserved protein, contains C1, PH and RUN domains","-","-"]
["TAP2",2.749929695,0.564052879,2.274603526,3.52432193,{"v":7.7e-07,"d":"7.70E-07"},{"v":3.73e-06,"d":"3.73E-06"},"ENSG00000204267","A0A087WYD6,Antigen peptide transporter 2","-","PF00005,ABC transporter;PF00664,ABC transporter transmembrane region","IPR005293,Antigen peptide transporter 2;IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR011527,ABC transporter type 1, transmembrane domain;IPR036640,ABC transporter type 1, transmembrane domain superfamily;IPR003593,AAA+ ATPase domain;IPR013305,ABC transporter Tap-like;IPR017871,ABC transporter, conserved site","KOG0058,Peptide exporter, ABC superfamily;COG1132,ABC-type multidrug transport system, ATPase and permease components","GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0015197,-,-;GO:0019885,biological_process,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0042287,molecular_function,MHC protein binding;GO:0055085,biological_process,transmembrane transport;GO:0000166,molecular_function,nucleotide binding;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0015833,biological_process,peptide transport;GO:0016887,molecular_function,ATPase activity;GO:0042825,cellular_component,TAP complex;GO:0016607,cellular_component,nuclear speck;GO:0016020,cellular_component,membrane;GO:0015440,molecular_function,peptide-transporting ATPase activity;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","-"]
["NOMO1",22.36263269,4.617357363,2.274485288,6.314610223,{"v":5.42e-18,"d":"5.42E-18"},{"v":3.06e-16,"d":"3.06E-16"},"ENSG00000103512","A0A087X117,Nodal modulator 1","-","PF13620,Carboxypeptidase regulatory-like domain","IPR008969,Carboxypeptidase-like, regulatory domain superfamily;IPR013784,Carbohydrate-binding-like fold","KOG1948,Metalloproteinase-related collagenase pM5;ENOG410XTI0,-","GO:0030246,molecular_function,carbohydrate binding","-"]
["FRMD5",3.345010289,0.687440167,2.274142843,3.848377417,{"v":5.85e-08,"d":"5.85E-08"},{"v":3.63e-07,"d":"3.63E-07"},"ENSG00000171877","K7CUE2,FERM domain containing 5","-","PF09379,RM N-terminal domain;PF00373,RM central domain;PF08736,RM adjacent (FA);PF09380,RM C-terminal PH-like domain","-","-","-","-"]
["RALGAPA2",1.963861839,0.403597416,2.274142843,3.848377417,{"v":5.85e-08,"d":"5.85E-08"},{"v":3.63e-07,"d":"3.63E-07"},"ENSG00000188559","H2RCW8,Uncharacterized protein","-","PF02145,Rap/ran-GAP","IPR016024,Armadillo-type fold;IPR027107,Tuberin/Ral GTPase-activating protein subunit alpha;IPR035974,Rap/Ran-GAP superfamily;IPR000331,Rap GTPase activating protein domain","ENOG410XTIX,-;KOG3686,Rap1-GTPase-activating protein (Rap1GAP)","GO:0090630,biological_process,activation of GTPase activity;GO:0005737,cellular_component,cytoplasm;GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0005634,cellular_component,nucleus","-"]
["STAC",6.15797465,1.267124333,2.273843676,4.112173961,{"v":8.19e-09,"d":"8.19E-09"},{"v":6.14e-08,"d":"6.14E-08"},"ENSG00000144681","H2QM98,Uncharacterized protein","XP_516358.3,SH3 and cysteine-rich domain-containing protein isoform X1","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF16664,Unstructured on SH3 and cysteine-rich domain-containing protein 2;PF00018,SH3 domain","IPR001452,SH3 domain;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR036028,SH3-like domain superfamily;IPR035508,STAC1","ENOG410IF5B,-;ENOG410XQKX,-","GO:0030315,cellular_component,T-tubule;GO:0044325,molecular_function,ion channel binding;GO:1903078,biological_process,positive regulation of protein localization to plasma membrane;GO:0035556,biological_process,intracellular signal transduction;GO:1901385,biological_process,regulation of voltage-gated calcium channel activity;GO:0006936,biological_process,muscle contraction;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular;GO:0034605,biological_process,cellular response to heat;GO:2001259,biological_process,positive regulation of cation channel activity","-"]
["SETD1A",30.51240748,6.313086802,2.272075227,7.002439039,{"v":2.17e-20,"d":"2.17E-20"},{"v":1.9e-18,"d":"1.90E-18"},"ENSG00000099381","A0A1D5R1K8,SET domain containing 1A","-","-","IPR037841,Histone-lysine N-methyltransferase SETD1A;IPR034467,Set1A, RNA recognition motif;IPR003616,Post-SET domain;IPR001214,SET domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR024657,COMPASS complex Set1 subunit, N-SET domain;IPR035979,RNA-binding domain superfamily","-","GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0042800,molecular_function,histone methyltransferase activity (H3-K4 specific);GO:0003676,molecular_function,nucleic acid binding;GO:0034968,biological_process,histone lysine methylation;GO:0016740,molecular_function,transferase activity;GO:0003723,molecular_function,RNA binding;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0051568,biological_process,histone H3-K4 methylation;GO:0005634,cellular_component,nucleus;GO:0048188,cellular_component,Set1C/COMPASS complex","-"]
["AC009065.1",206.5063088,42.71218092,2.271750709,6.087556308,{"v":4.94e-17,"d":"4.94E-17"},{"v":2.35e-15,"d":"2.35E-15"},"ENSG00000279473","H2QAD2,Uncharacterized protein","-","-","-","ENOG4111EET,-;ENOG410J0PA,-","-","-"]
["DENND5B",3.086352021,0.637364791,2.27026095,4.46330434,3.44E-10,{"v":3.52e-09,"d":"3.52E-09"},"ENSG00000170456","G3V1S3,DENN domain-containing protein 5B","NP_001295268.1,DENN domain-containing protein 5B isoform 2","PF02141,NN (AEX-3) domain;PF02759,RUN domain;PF01477,PLAT/LH2 domain;PF03455,dDENN domain;PF03456,uDENN domain","IPR005112,dDENN domain;IPR036392,PLAT/LH2 domain superfamily;IPR037213,RUN domain superfamily;IPR004012,RUN domain;IPR001194,cDENN domain;IPR037516,Tripartite DENN domain;IPR001024,PLAT/LH2 domain;IPR005113,uDENN domain","ENOG410XNYP,-;KOG2080,Uncharacterized conserved protein, contains DENN and RUN domains","-","-"]
["ATP13A3",14.93132741,3.093248976,2.27007535,6.755282872,{"v":1.34e-19,"d":"1.34E-19"},1.04E-17,"ENSG00000133657","H2QP02,Cation-transporting ATPase","XP_016798013.1,-;XP_016798012.1,probable cation-transporting ATPase 13A3 isoform X3","PF12409,P5-type ATPase cation transporter;PF00690,Cation transporter/ATPase, N-terminus;PF00122,1-E2 ATPase;PF00702,haloacid dehalogenase-like hydrolase;PF00689,Cation transporting ATPase, C-terminus","IPR006544,P-type ATPase, subfamily  V;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR023299,P-type ATPase, cytoplasmic domain N;IPR018303,P-type ATPase, phosphorylation site;IPR001757,P-type ATPase;IPR023298,P-type ATPase, transmembrane domain superfamily;IPR006068,Cation-transporting P-type ATPase, C-terminal;IPR008250,P-type ATPase, A domain superfamily;IPR004014,Cation-transporting P-type ATPase, N-terminal","KOG0208,Cation transport ATPase;ENOG410XRCA,-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016787,molecular_function,hydrolase activity;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0099132,biological_process,ATP hydrolysis coupled cation transmembrane transport;GO:0005388,molecular_function,calcium-transporting ATPase activity;GO:0046872,molecular_function,metal ion binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0006812,biological_process,cation transport;GO:0016887,molecular_function,ATPase activity;GO:0016020,cellular_component,membrane;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane;GO:0070588,biological_process,calcium ion transmembrane transport","-"]
["BIRC6",6.873387944,1.423578698,2.269939859,6.221430955,{"v":1.39e-17,"d":"1.39E-17"},{"v":7.23e-16,"d":"7.23E-16"},"ENSG00000115760","K7C5B8,Baculoviral IAP repeat containing 6","XP_016803811.1,baculoviral IAP repeat-containing protein 6 isoform X11","PF00653,Inhibitor of Apoptosis domain;PF00179,Ubiquitin-conjugating enzyme;PF12356,Baculoviral IAP repeat-containing protein 6","IPR001370,BIR repeat;IPR000608,Ubiquitin-conjugating enzyme E2;IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR022103,Baculoviral IAP repeat-containing protein 6","KOG0895,Ubiquitin-conjugating enzyme;KOG1101,Apoptosis inhibitor IAP1 and related BIR domain proteins;ENOG410XP8C,-","GO:0006915,biological_process,apoptotic process;GO:0032465,biological_process,regulation of cytokinesis;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["FUCA1",12.41242577,2.561121212,2.269449691,4.025971216,{"v":1.02E-8,"d":"1.02E-08"},{"v":7.51e-08,"d":"7.51E-08"},"ENSG00000179163","G3QV26,Fucosidase, alpha-L- 1, tissue","XP_018868217.1,tissue alpha-L-fucosidase","PF01120,Alpha-L-fucosidase;PF16757,Alpha-L-fucosidase C-terminal domain","IPR031919,Alpha-L-fucosidase, C-terminal;IPR016286,Alpha-L-fucosidase, metazoa-type;IPR000933,Glycoside hydrolase, family 29;IPR028755,Tissue alpha-L-fucosidase;IPR017853,Glycoside hydrolase superfamily;IPR018526,Glycoside hydrolase, family 29, conserved site;IPR013780,Glycosyl hydrolase, all-beta","-","GO:0005975,biological_process,carbohydrate metabolic process;GO:0004560,molecular_function,alpha-L-fucosidase activity;GO:0006004,biological_process,fucose metabolic process;GO:0016139,biological_process,glycoside catabolic process","K01206,ko00511,Other glycan degradation"]
["WDR36",3.31873505,0.68477209,2.269449691,4.025971216,{"v":1.02E-8,"d":"1.02E-08"},{"v":7.51e-08,"d":"7.51E-08"},"ENSG00000134987","H2QRB0,Uncharacterized protein","XP_517870.2,WD repeat-containing protein 36 isoform X1","PF12894,Anaphase-promoting complex subunit 4 WD40 domain;PF04192,Utp21 specific WD40 associated putative domain;PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR024977,Anaphase-promoting complex subunit 4, WD40 domain;IPR036322,WD40-repeat-containing domain superfamily;IPR007319,Small-subunit processome, Utp21;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat","KOG1539,WD repeat protein;ENOG410XPJH,-","GO:0032040,cellular_component,small-subunit processome;GO:0005730,cellular_component,nucleolus;GO:0001895,biological_process,retina homeostasis;GO:0030516,biological_process,regulation of axon extension;GO:0006364,biological_process,rRNA processing;GO:0034388,cellular_component,Pwp2p-containing subcomplex of 90S preribosome","-"]
["NUDT19",6.962936515,1.435667269,2.268765138,3.743979256,{"v":1.73E-7,"d":"1.73E-07"},{"v":9.6e-07,"d":"9.60E-07"},"ENSG00000213965","G3QXQ6,Nudix hydrolase 19","XP_004060500.1,nucleoside diphosphate-linked moiety X motif 19","-","IPR015797,NUDIX hydrolase-like domain superfamily;IPR000086,NUDIX hydrolase domain","-","GO:0016787,molecular_function,hydrolase activity;GO:0005739,cellular_component,mitochondrion;GO:0005102,molecular_function,signaling receptor binding","K13355,ko04146,Peroxisome"]
["SAGE1",6.995947389,1.442473683,2.268765138,3.743979256,{"v":1.73E-7,"d":"1.73E-07"},{"v":9.6e-07,"d":"9.60E-07"},"ENSG00000181433","B7ZM42,SAGE1 protein","-","PF15300,INTS6/SAGE1/DDX26B/CT45 C-terminus","IPR029307,INTS6/SAGE1/DDX26B/CT45, C-terminal","-","-","-"]
["FERMT1",14.75540742,3.057132348,2.268592836,5.608769361,{"v":4.48e-15,"d":"4.48E-15"},{"v":1.39e-13,"d":"1.39E-13"},"ENSG00000101311","Q54A15,DTGCU2","NP_060141.3,fermitin family homolog 1","PF00373,RM central domain;PF00169,PH domain","IPR019748,FERM central domain;IPR037837,Kindlin/fermitin, PH domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR037843,Kindlin/fermitin","KOG3727,Mitogen inducible gene product (contains ERM and PH domains);ENOG410XS1B,-","GO:0007229,biological_process,integrin-mediated signaling pathway","-"]
["DCAF11",16.67830312,3.45723635,2.26848998,6.022740642,{"v":8.19e-17,"d":"8.19E-17"},{"v":3.65e-15,"d":"3.65E-15"},"ENSG00000100897","K7AJC9,DDB1 and CUL4 associated factor 11","XP_509863.3,-;XP_016781403.1,-;XP_003314313.1,-","PF00400,WD domain, G-beta repeat","IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR017399,WD repeat protein DCAF11/LEC14B;IPR001680,WD40 repeat","ENOG410XP3K,-;KOG0266,WD40 repeat-containing protein","GO:0080008,cellular_component,Cul4-RING E3 ubiquitin ligase complex;GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-390B4.3",28.56342861,5.882647129,2.26767345,3.391876667,{"v":2.62e-06,"d":"2.62E-06"},{"v":1.13E-5,"d":"1.13E-05"},"-","-","-","-","-","-","-","-"]
["RP11-66N24.4",3.121410582,0.642855494,2.26767345,3.391876667,{"v":2.62e-06,"d":"2.62E-06"},{"v":1.13E-5,"d":"1.13E-05"},"ENSG00000157306","G7MIS0,Uncharacterized protein","-","-","-","-","-","-"]
["CYP2S1",28.58775583,5.928496571,2.267351922,5.663116968,{"v":2.27e-15,"d":"2.27E-15"},{"v":7.5e-14,"d":"7.50E-14"},"ENSG00000167600","G3RN34,Cytochrome P450 family 2 subfamily S member 1","XP_004060829.2,cytochrome P450 2S1","PF00067,Cytochrome P450","IPR001128,Cytochrome P450;IPR008067,Cytochrome P450, E-class, group I, CYP2A-like;IPR002401,Cytochrome P450, E-class, group I;IPR036396,Cytochrome P450 superfamily;IPR017972,Cytochrome P450, conserved site","-","GO:0016705,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016020,cellular_component,membrane;GO:0016712,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497,molecular_function,monooxygenase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0046872,molecular_function,metal ion binding;GO:0005506,molecular_function,iron ion binding;GO:0055114,biological_process,oxidation-reduction process;GO:0020037,molecular_function,heme binding;GO:0016021,cellular_component,integral component of membrane","-"]
["ANKRD13A",13.53684366,2.808543815,2.2670926,5.934335413,{"v":1.72e-16,"d":"1.72E-16"},{"v":7.15e-15,"d":"7.15E-15"},"ENSG00000076513","H2Q6V1,Ankyrin repeat domain 13A","XP_509359.3,-","PF12796,Ankyrin repeats (3 copies);PF11904,PCR-chaperone","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily;IPR003903,Ubiquitin interacting motif;IPR021832,Ankyrin repeat domain-containing protein 13","KOG0522,Ankyrin repeat protein;ENOG410XNMS,-","GO:0005737,cellular_component,cytoplasm;GO:0005886,cellular_component,plasma membrane","-"]
["EPAS1",23.12163288,4.801422709,2.266587841,6.687238791,{"v":2.49e-19,"d":"2.49E-19"},{"v":1.84e-17,"d":"1.84E-17"},"ENSG00000116016","H2QHV1,Endothelial PAS domain protein 1","XP_001147219.1,endothelial PAS domain-containing protein 1 isoform X2","PF08778,HIF-1 alpha C terminal transactivation domain;PF08447,PAS fold;PF11413,Hypoxia-inducible factor-1;PF00989,PAS fold","IPR000014,PAS domain;IPR001067,Nuclear translocator;IPR001610,PAC motif;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR014887,HIF-1 alpha, transactivation domain, C-terminal;IPR035965,PAS domain superfamily;IPR013655,PAS fold-3;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR013767,PAS fold;IPR021537,Hypoxia-inducible factor, alpha subunit","KOG3558,Hypoxia-inducible factor 1/Neuronal PAS domain protein NPAS1;ENOG410YK57,-","GO:0046983,molecular_function,protein dimerization activity;GO:0016607,cellular_component,nuclear speck;GO:0007005,biological_process,mitochondrion organization;GO:0042415,biological_process,norepinephrine metabolic process;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0046982,molecular_function,protein heterodimerization activity;GO:0030218,biological_process,erythrocyte differentiation;GO:0007601,biological_process,visual perception;GO:0005634,cellular_component,nucleus;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0002027,biological_process,regulation of heart rate;GO:0001974,biological_process,blood vessel remodeling;GO:0055072,biological_process,iron ion homeostasis;GO:0030097,biological_process,hemopoiesis;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0035035,molecular_function,histone acetyltransferase binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0001525,biological_process,angiogenesis;GO:0006979,biological_process,response to oxidative stress;GO:0030154,biological_process,cell differentiation;GO:0071456,biological_process,cellular response to hypoxia;GO:0030324,biological_process,lung development;GO:0048469,biological_process,cell maturation;GO:0005667,cellular_component,transcription factor complex;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001892,biological_process,embryonic placenta development;GO:0043129,biological_process,surfactant homeostasis;GO:0043619,biological_process,regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0001666,biological_process,response to hypoxia;GO:0048625,biological_process,myoblast fate commitment","K09095,ko05211,Renal cell carcinoma;K09095,ko05200,Pathways in cancer"]
["PPP2R2D",13.83857474,2.872758415,2.266422383,6.042061241,{"v":6.76e-17,"d":"6.76E-17"},3.06E-15,"ENSG00000175470","K7BV01,Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B","XP_016775124.1,-","-","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR018067,Protein phosphatase 2A regulatory subunit PR55, conserved site;IPR000009,Protein phosphatase 2A regulatory subunit PR55","KOG1354,Serine/threonine protein phosphatase 2A, regulatory subunit;COG5170,Serine/threonine protein phosphatase 2A, regulatory subunit","GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0019888,molecular_function,protein phosphatase regulator activity;GO:0000159,cellular_component,protein phosphatase type 2A complex","-"]
["IQSEC1",6.417841764,1.333126484,2.26299598,4.791557022,{"v":1.19e-11,"d":"1.19E-11"},{"v":1.68e-10,"d":"1.68E-10"},"ENSG00000144711","A0A087WWK8,IQ motif and SEC7 domain-containing protein 1","NP_001127854.1,IQ motif and SEC7 domain-containing protein 1 isoform a","PF01369,Sec7 domain;PF16453,PH domain","IPR033742,IQ motif and SEC7 domain-containing protein, PH domain;IPR023394,Sec7, C-terminal domain superfamily;IPR011993,PH-like domain superfamily;IPR001849,Pleckstrin homology domain;IPR000048,IQ motif, EF-hand binding site;IPR030737,IQ motif and SEC7 domain-containing protein 1;IPR035999,Sec7 domain superfamily;IPR000904,Sec7 domain","COG5307,SEC7 domain proteins;KOG0931,Predicted guanine nucleotide exchange factor, contains Sec7 domain","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0032012,biological_process,regulation of ARF protein signal transduction;GO:0005086,molecular_function,ARF guanyl-nucleotide exchange factor activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005730,cellular_component,nucleolus","-"]
["ADAMTS6",3.68649461,0.764943259,2.26283872,4.326071852,{"v":9.18e-10,"d":"9.18E-10"},{"v":8.52e-09,"d":"8.52E-09"},"ENSG00000049192","H2R5K7,ADAM metallopeptidase with thrombospondin type 1 motif, 6","XP_526907.2,A disintegrin and metalloproteinase with thrombospondin motifs 6","PF05986,ADAM-TS Spacer 1;PF01421,Reprolysin (M12B) family zinc metalloprotease;PF08686,PLAC (protease and lacunin) domain;PF00090,Thrombospondin type 1 domain;PF01562,Reprolysin family propeptide","IPR010294,ADAM-TS Spacer 1;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR001590,Peptidase M12B, ADAM/reprolysin;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR010909,PLAC;IPR002870,Peptidase M12B, propeptide;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","KOG4597,Serine proteinase inhibitor (KU family) with thrombospondin repeats;ENOG410XPKZ,-;KOG3538,Disintegrin metalloproteinases with thrombospondin repeats","GO:0008237,molecular_function,metallopeptidase activity;GO:0046872,molecular_function,metal ion binding;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0008233,molecular_function,peptidase activity;GO:0006508,biological_process,proteolysis","-"]
["ZNF518A",1.744266975,0.361028495,2.262473534,3.631299014,{"v":2.39e-07,"d":"2.39E-07"},{"v":1.28E-6,"d":"1.28E-06"},"ENSG00000177853","K7DEU1,Zinc finger protein 518A","XP_016774469.1,-;XP_016774473.1,-;XP_009457297.1,-;XP_016774476.1,-;XP_016774478.1,-;XP_016774479.1,-;XP_016774483.1,-;XP_016774485.1,-;XP_016774477.1,-;XP_016774484.1,-;XP_016774471.1,-;XP_016774482.1,-;XP_016774475.1,-;XP_003951766.1,zinc finger protein 518A isoform X1;XP_016774480.1,-;XP_016774468.1,-;XP_016774467.1,-;XP_016774466.1,-;XP_016774474.1,-;XP_016774470.1,-;XP_016774486.1,-","-","IPR013087,Zinc finger C2H2-type;IPR027760,Zinc finger protein 518;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["DRAM1",4.544691776,0.940660608,2.262473534,3.631299014,{"v":2.39e-07,"d":"2.39E-07"},{"v":1.28E-6,"d":"1.28E-06"},"ENSG00000136048","H2Q6Q5,DNA-damage regulated autophagy modulator 1","XP_001155589.1,-","PF10277,rag1/DRAM/Sfk1 family","IPR019402,Frag1/DRAM/Sfk1","ENOG4111KNB,-;KOG4320,Uncharacterized conserved protein","GO:0005737,cellular_component,cytoplasm;GO:0010506,biological_process,regulation of autophagy;GO:0016021,cellular_component,integral component of membrane;GO:0005764,cellular_component,lysosome;GO:0016020,cellular_component,membrane","-"]
["DHRS4-AS1",5.287172731,1.094339366,2.262473534,3.631299014,{"v":2.39e-07,"d":"2.39E-07"},{"v":1.28E-6,"d":"1.28E-06"},"ENSG00000215256","F6YYL9,Uncharacterized protein","-","-","-","-","GO:0048741,biological_process,skeletal muscle fiber development","-"]
["ARAP2",3.171739951,0.659123441,2.261863744,4.633309982,{"v":8.22e-11,"d":"8.22E-11"},{"v":9.54e-10,"d":"9.54E-10"},"ENSG00000047365","G3RS92,ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2","XP_018881416.1,arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2","PF01412,Putative GTPase activating protein for Arf;PF00536,SAM domain (Sterile alpha motif);PF00620,RhoGAP domain;PF00788,Ras association (RalGDS/AF-6) domain;PF00169,PH domain","IPR037858,ARAP, RhoGAP domain;IPR037278,ARFGAP/RecO-like zinc finger;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR038508,ArfGAP domain superfamily;IPR000159,Ras-associating (RA) domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain;IPR001164,Arf GTPase activating protein;IPR001660,Sterile alpha motif domain","-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005547,molecular_function,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0007165,biological_process,signal transduction;GO:0005096,molecular_function,GTPase activator activity","-"]
["MYO9B",14.70400578,3.063198672,2.261809165,6.483392699,1.81E-18,1.14E-16,"ENSG00000099331","M0R0P8,Unconventional myosin-IXb","-","PF00788,Ras association (RalGDS/AF-6) domain;PF00620,RhoGAP domain;PF00063,Myosin head (motor domain);PF00612,IQ calmodulin-binding motif","IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR000159,Ras-associating (RA) domain;IPR000048,IQ motif, EF-hand binding site;IPR000198,Rho GTPase-activating protein domain;IPR028557,Unconventional myosin-IXb;IPR036961,Kinesin motor domain superfamily;IPR036023,Class IX myosin, motor domain;IPR008936,Rho GTPase activation protein;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR029071,Ubiquitin-like domain superfamily","KOG1453,Chimaerin and related Rho GTPase activating proteins;KOG4229,Myosin VII, myosin IXB and related myosins;COG5022,Myosin heavy chain","GO:0035556,biological_process,intracellular signal transduction;GO:0008017,molecular_function,microtubule binding;GO:0046872,molecular_function,metal ion binding;GO:0005524,molecular_function,ATP binding;GO:0003774,molecular_function,motor activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0003779,molecular_function,actin binding;GO:0005096,molecular_function,GTPase activator activity;GO:0005829,cellular_component,cytosol;GO:0007018,biological_process,microtubule-based movement;GO:0016459,cellular_component,myosin complex;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity;GO:0007165,biological_process,signal transduction","-"]
["CBLB",3.991095347,0.830228324,2.261212258,4.886166338,7.25E-12,1.08E-10,"ENSG00000114423","H2QN18,Cas-Br-M","XP_016797076.1,-;XP_009444362.1,-;XP_003309960.1,E3 ubiquitin-protein ligase CBL-B isoform X1;XP_009444363.1,-","PF02761,CBL proto-oncogene N-terminus, EF hand-like domain;PF02262,CBL proto-oncogene N-terminal domain 1;PF02762,CBL proto-oncogene N-terminus, SH2-like domain;PF14447,Prokaryotic RING finger family 4","IPR017907,Zinc finger, RING-type, conserved site;IPR036537,Adaptor protein Cbl, N-terminal domain superfamily;IPR003153,Adaptor protein Cbl, N-terminal helical;IPR015940,Ubiquitin-associated domain;IPR001841,Zinc finger, RING-type;IPR024162,Adaptor protein Cbl;IPR036860,SH2 domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011992,EF-hand domain pair;IPR014741,Adaptor protein Cbl, EF hand-like;IPR024159,Adaptor protein Cbl, PTB domain;IPR014742,Adaptor protein Cbl, SH2-like domain","ENOG410YDNH,-;KOG1785,Tyrosine kinase negative regulator CBL","GO:0005829,cellular_component,cytosol;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:0016567,biological_process,protein ubiquitination;GO:0023051,biological_process,regulation of signaling;GO:0007175,biological_process,negative regulation of epidermal growth factor-activated receptor activity;GO:0004871,molecular_function,signal transducer activity;GO:0005509,molecular_function,calcium ion binding;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0006508,biological_process,proteolysis;GO:0045121,cellular_component,membrane raft;GO:0017124,molecular_function,SH3 domain binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0030971,molecular_function,receptor tyrosine kinase binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K04707,ko05100,Bacterial invasion of epithelial cells;K04707,ko05220,Chronic myeloid leukemia;K04707,ko05200,Pathways in cancer;K04707,ko04012,ErbB signaling pathway;K04707,ko04144,Endocytosis;K04707,ko04120,Ubiquitin mediated proteolysis;K04707,ko05205,Proteoglycans in cancer;K04707,ko04660,T cell receptor signaling pathway;K04707,ko04910,Insulin signaling pathway"]
["TTI1",5.990845371,1.24364335,2.261148838,4.102029276,{"v":1.09E-8,"d":"1.09E-08"},{"v":7.95e-08,"d":"7.95E-08"},"ENSG00000101407","H2QKB8,Tel2 interacting protein 1 homolog","XP_514634.2,TELO2-interacting protein 1 homolog isoform X1;XP_009435459.1,-","-","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR016441,TEL2-interacting protein 1","ENOG410XSN6,-;KOG4524,Uncharacterized conserved protein","GO:0005737,cellular_component,cytoplasm;GO:0031931,cellular_component,TORC1 complex;GO:0032006,biological_process,regulation of TOR signaling;GO:0031932,cellular_component,TORC2 complex","K20403,ko04150,mTOR signaling pathway"]
["ADGRB2",0.826640526,0.168985789,2.260683648,2.212694446,0.001177692,2.803224E-3,"ENSG00000121753","G3RKG0,Adhesion G protein-coupled receptor B2","-","PF00002,7 transmembrane receptor (Secretin family);PF16489,PCR-Autoproteolysis INducing (GAIN) domain;PF00090,Thrombospondin type 1 domain;PF01825,PCR proteolysis site, GPS, motif","IPR001879,GPCR, family 2, extracellular hormone receptor domain;IPR036445,GPCR family 2, extracellular hormone receptor domain superfamily;IPR032471,GAIN domain, N-terminal;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR000203,GPS motif;IPR017981,GPCR, family 2-like;IPR008077,GPCR, family 2, brain-specific angiogenesis inhibitor;IPR000832,GPCR, family 2, secretin-like;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","-","GO:0016525,biological_process,negative regulation of angiogenesis;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0007422,biological_process,peripheral nervous system development;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0033173,biological_process,calcineurin-NFAT signaling cascade;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0005813,cellular_component,centrosome;GO:0016021,cellular_component,integral component of membrane","-"]
["IL15RA",1.764288366,0.360664221,2.260683648,2.212694446,0.001177692,2.803224E-3,"ENSG00000134470","A0A0A0MS77,Interleukin-15 receptor subunit alpha","NP_001243694.1,interleukin-15 receptor subunit alpha isoform 4","-","IPR000436,Sushi/SCR/CCP domain;IPR035976,Sushi/SCR/CCP superfamily","ENOG410IWP4,-;ENOG410Z8MM,-","-","-"]
["ENKUR",1.572969559,0.321553921,2.260683648,2.212694446,0.001177692,2.803224E-3,"ENSG00000151023","Q5VV23,Chromosome 10 open reading frame 63, isoform CRA_b","-","PF13864,Calmodulin-binding","IPR027012,Enkurin domain;IPR026150,Enkurin","ENOG410ZNA7,-;ENOG410IET1,-","-","-"]
["RP11-77H9.5",15.67585311,3.20453247,2.260683648,2.212694446,0.001177692,2.803224E-3,"-","-","-","-","-","-","-","-"]
["CTD-2541J13.2",1.939916467,0.396566953,2.260683648,2.212694446,0.001177692,2.803224E-3,"ENSG00000263424","H2RB09,Dermatan sulfate epimerase-like","XP_523962.1,dermatan-sulfate epimerase-like protein","PF00685,Sulfotransferase domain","IPR008929,Chondroitin AC/alginate lyase;IPR000863,Sulfotransferase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410Y713,-;ENOG410IE6W,-","GO:0008146,molecular_function,sulfotransferase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PARD6G",1.517856042,0.310287353,2.260683648,2.212694446,0.001177692,2.803224E-3,"ENSG00000178184","H2QER6,Par-6 family cell polarity regulator gamma","XP_001145392.1,partitioning defective 6 homolog gamma","PF00595,PDZ domain (Also known as DHR or GLGF);PF00564,PB1 domain","IPR000270,PB1 domain;IPR034874,Partitioning defective 6 homologue gamma;IPR036034,PDZ superfamily;IPR034868,Partitioning defective protein 6, PB1 domain;IPR001478,PDZ domain","KOG3606,Cell polarity protein PAR6;ENOG410XRJ3,-","GO:0007163,biological_process,establishment or maintenance of cell polarity","K06093,ko04015,Rap1 signaling pathway;K06093,ko04530,Tight junction;K06093,ko04360,Axon guidance;K06093,ko04391,Hippo signaling pathway - fly;K06093,ko04390,Hippo signaling pathway;K06093,ko04144,Endocytosis"]
["MTSS1",0.829742969,0.169620005,2.260683648,2.212694446,0.001177692,2.803224E-3,"ENSG00000170873","K7D2N1,Metastasis suppressor 1","XP_009454163.1,metastasis suppressor protein 1 isoform X1","PF08397,IRSp53/MIM homology domain;PF02205,WH2 motif","IPR003124,WH2 domain;IPR030127,I-BAR domain containing protein MIM/ABBA;IPR027267,AH/BAR domain superfamily;IPR027682,I-BAR domain containing protein MIM;IPR013606,IMD/I-BAR domain","ENOG410IGVU,-;ENOG410XRT4,-","GO:0030036,biological_process,actin cytoskeleton organization;GO:0015629,cellular_component,actin cytoskeleton;GO:0005102,molecular_function,signaling receptor binding;GO:0003785,molecular_function,actin monomer binding;GO:0007009,biological_process,plasma membrane organization;GO:0003779,molecular_function,actin binding;GO:0042802,molecular_function,identical protein binding","-"]
["AMOT",0.75410773,0.15415829,2.260683648,2.212694446,0.001177692,2.803224E-3,"ENSG00000126016","H2QZ09,Uncharacterized protein","XP_009437816.1,-;XP_009437817.1,-;XP_009437815.1,-;XP_009437814.1,angiomotin isoform X1","PF12240,Angiomotin C terminal","IPR009114,Angiomotin;IPR024646,Angiomotin, C-terminal","ENOG410XSY2,-;ENOG410IJU5,-","GO:0005884,cellular_component,actin filament;GO:0035329,biological_process,hippo signaling;GO:0001726,cellular_component,ruffle;GO:0001570,biological_process,vasculogenesis;GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0030054,cellular_component,cell junction;GO:0006935,biological_process,chemotaxis;GO:0005634,cellular_component,nucleus;GO:0048514,biological_process,blood vessel morphogenesis;GO:0005923,cellular_component,bicellular tight junction;GO:0043534,biological_process,blood vessel endothelial cell migration;GO:0030027,cellular_component,lamellipodium;GO:0043532,molecular_function,angiostatin binding;GO:0034613,biological_process,cellular protein localization;GO:0030036,biological_process,actin cytoskeleton organization;GO:0030334,biological_process,regulation of cell migration;GO:0003365,biological_process,establishment of cell polarity involved in ameboidal cell migration;GO:0009897,cellular_component,external side of plasma membrane;GO:0040019,biological_process,positive regulation of embryonic development;GO:0004872,-,-;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0042074,biological_process,cell migration involved in gastrulation;GO:0001701,biological_process,in utero embryonic development;GO:0008180,cellular_component,COP9 signalosome;GO:0001702,biological_process,gastrulation with mouth forming second;GO:0034260,biological_process,negative regulation of GTPase activity;GO:0030139,cellular_component,endocytic vesicle","-"]
["PHF12",9.127853789,1.902682964,2.260552404,6.098516423,{"v":5.25e-17,"d":"5.25E-17"},{"v":2.46e-15,"d":"2.46E-15"},"ENSG00000109118","A8K5V5,cDNA FLJ78652, highly similar to Homo sapiens PHD finger protein 12","-","PF00628,PHD-finger;PF16737,PHD finger protein 12 MRG binding domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR031966,PHD finger protein 12, MRG binding domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000253,Forkhead-associated (FHA) domain;IPR036427,Bromodomain-like superfamily;IPR008984,SMAD/FHA domain superfamily;IPR019787,Zinc finger, PHD-finger;IPR038098,PHD finger protein 12, MRG binding domain superfamily;IPR019786,Zinc finger, PHD-type, conserved site","ENOG410XQQA,-;KOG4299,PHD Zn-finger protein","GO:0046872,molecular_function,metal ion binding","-"]
["CAMKK2",5.002046056,1.040051333,2.260422899,4.455392646,{"v":4.43e-10,"d":"4.43E-10"},{"v":4.44e-09,"d":"4.44E-09"},"ENSG00000110931","K7DNN3,Calcium/calmodulin-dependent protein kinase kinase 2, beta","XP_016779888.1,-;XP_016779887.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0585,Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases;ENOG410YHHF,-","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0046777,biological_process,protein autophosphorylation;GO:0005509,molecular_function,calcium ion binding;GO:0005524,molecular_function,ATP binding;GO:0061762,biological_process,CAMKK-AMPK signaling cascade;GO:0005622,cellular_component,intracellular;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0016310,biological_process,phosphorylation;GO:0001934,biological_process,positive regulation of protein phosphorylation","-"]
["CDC14B",9.464813667,1.973121491,2.260192133,5.92869141,{"v":2.25e-16,"d":"2.25E-16"},{"v":9.13e-15,"d":"9.13E-15"},"ENSG00000081377","H2PST4,Cell division cycle 14B","XP_002820045.1,-","PF00782,ual specificity phosphatase, catalytic domain;PF14671,ual specificity protein phosphatase, N-terminal half","IPR029260,Dual specificity/tyrosine protein phosphatase, N-terminal;IPR029021,Protein-tyrosine phosphatase-like;IPR016130,Protein-tyrosine phosphatase, active site;IPR000340,Dual specificity phosphatase, catalytic domain;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR020422,Dual specificity protein phosphatase domain;IPR000387,Tyrosine specific protein phosphatases domain","COG2453,Predicted protein-tyrosine phosphatase;KOG1720,Protein tyrosine phosphatase CDC14","GO:0004722,molecular_function,protein serine/threonine phosphatase activity;GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0005730,cellular_component,nucleolus;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0072425,biological_process,signal transduction involved in G2 DNA damage checkpoint;GO:0006470,biological_process,protein dephosphorylation;GO:1904668,biological_process,positive regulation of ubiquitin protein ligase activity;GO:0016311,biological_process,dephosphorylation;GO:0005654,cellular_component,nucleoplasm;GO:0005634,cellular_component,nucleus;GO:0016791,molecular_function,phosphatase activity","K06639,ko04110,Cell cycle;K06639,ko04113,Meiosis - yeast;K06639,ko04111,Cell cycle - yeast"]
["CYFIP2",1.357173625,0.280907888,2.259175814,3.245747738,{"v":9.37e-06,"d":"9.37E-06"},{"v":3.59e-05,"d":"3.59E-05"},"ENSG00000055163","A0A1U7QPM2,cytoplasmic FMR1-interacting protein 2 isoform X1","XP_012970215.1,-;XP_005071954.1,-","-","IPR009828,Protein of unknown function DUF1394;IPR008081,Cytoplasmic FMR1-interacting","-","-","-"]
["TPGS2",11.88311577,2.479715789,2.259168584,6.266932039,{"v":9.6e-18,"d":"9.60E-18"},{"v":5.17e-16,"d":"5.17E-16"},"ENSG00000134779","G7PWN9,Uncharacterized protein","XP_005586903.1,tubulin polyglutamylase complex subunit 2 isoform X6","-","IPR018958,Knr4/Smi1-like domain","-","-","-"]
["RPUSD3",4.129355556,0.85775771,2.258736687,3.836139253,{"v":7.95e-08,"d":"7.95E-08"},{"v":4.77e-07,"d":"4.77E-07"},"ENSG00000156990","G3RBE8,RNA pseudouridylate synthase domain containing 3","XP_004033616.1,RNA pseudouridylate synthase domain-containing protein 3 isoform X1","PF00849,RNA pseudouridylate synthase","IPR006145,Pseudouridine synthase, RsuA/RluB/C/D/E/F;IPR020103,Pseudouridine synthase, catalytic domain superfamily","-","GO:0009451,biological_process,RNA modification;GO:0001522,biological_process,pseudouridine synthesis;GO:0003723,molecular_function,RNA binding;GO:0009982,molecular_function,pseudouridine synthase activity","-"]
["EGFR",440.6232334,92.08413979,2.258486875,11.70281639,{"v":7.9e-26,"d":"7.90E-26"},{"v":1.59e-23,"d":"1.59E-23"},"ENSG00000146648","A9CB80,Receptor protein-tyrosine kinase","-","PF14843,rowth factor receptor domain IV;PF00757,urin-like cysteine rich region;PF01030,Receptor L domain;PF07714,Protein tyrosine kinase","IPR032778,Growth factor receptor domain 4;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR006212,Furin-like repeat;IPR000494,Receptor L-domain;IPR016245,Tyrosine protein kinase, EGF/ERB/XmrK receptor;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR006211,Furin-like cysteine-rich domain;IPR036941,Receptor L-domain superfamily;IPR000719,Protein kinase domain","ENOG410XNSR,-;KOG1025,Epidermal growth factor receptor EGFR and related tyrosine kinases","GO:0016301,molecular_function,kinase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0035556,biological_process,intracellular signal transduction;GO:0004716,molecular_function,signal transducer, downstream of receptor, with protein tyrosine kinase activity;GO:0016020,cellular_component,membrane;GO:0016740,molecular_function,transferase activity;GO:0004714,molecular_function,transmembrane receptor protein tyrosine kinase activity;GO:0005524,molecular_function,ATP binding;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0004672,molecular_function,protein kinase activity;GO:0005622,cellular_component,intracellular;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0016021,cellular_component,integral component of membrane;GO:0023014,biological_process,signal transduction by protein phosphorylation","-"]
["SLC35F2",12.26589935,2.556427201,2.258324443,4.836610149,{"v":7.51e-12,"d":"7.51E-12"},1.11E-10,"ENSG00000110660","K7A5C9,Solute carrier family 35, member F2","XP_016777410.1,-","PF06027,Solute carrier family 35","IPR009262,Solute carrier family 35 member SLC35F1/F2/F6","KOG2766,Predicted membrane protein;COG0697,Permeases of the drug/metabolite transporter (DMT) superfamily","GO:0055085,biological_process,transmembrane transport;GO:0022857,molecular_function,transmembrane transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ASAP1",59.65182394,12.46545715,2.258249957,8.227341753,{"v":3.85e-23,"d":"3.85E-23"},{"v":5.08e-21,"d":"5.08E-21"},"ENSG00000153317","K7D7X0,ArfGAP with SH3 domain, ankyrin repeat and PH domain 1","XP_009454190.2,arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2","PF12796,Ankyrin repeats (3 copies);PF01412,Putative GTPase activating protein for Arf;PF00018,SH3 domain;PF16746,BAR domain of APPL family;PF00169,PH domain","IPR038016,ASAP1, SH3 domain;IPR038508,ArfGAP domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR037928,ASAP1, BAR domain;IPR002110,Ankyrin repeat;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain;IPR001164,Arf GTPase activating protein;IPR037278,ARFGAP/RecO-like zinc finger;IPR027267,AH/BAR domain superfamily;IPR037844,ASAP, PH domain","COG5347,GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport;KOG0521,Putative GTPase activating proteins (GAPs)","GO:0005546,molecular_function,phosphatidylinositol-4,5-bisphosphate binding;GO:0002102,cellular_component,podosome;GO:0005547,molecular_function,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043197,cellular_component,dendritic spine;GO:0031253,cellular_component,cell projection membrane;GO:0061000,biological_process,negative regulation of dendritic spine development;GO:0046872,molecular_function,metal ion binding;GO:0071803,biological_process,positive regulation of podosome assembly;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0001786,molecular_function,phosphatidylserine binding;GO:1903527,biological_process,positive regulation of membrane tubulation;GO:0060271,biological_process,cilium assembly;GO:0045296,molecular_function,cadherin binding","-"]
["SETD1B",8.3113907,1.73408607,2.258192581,5.420164457,2.34E-14,{"v":6.09e-13,"d":"6.09E-13"},"ENSG00000139718","A0A0A0MQV9,Histone-lysine N-methyltransferase SETD1B","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF11764,COMPASS (Complex proteins associated with Set1p) component N;PF00856,SET domain","IPR034468,Set1B, RNA recognition motif;IPR037842,Histone-lysine N-methyltransferase SETD1B;IPR003616,Post-SET domain;IPR001214,SET domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR024657,COMPASS complex Set1 subunit, N-SET domain;IPR035979,RNA-binding domain superfamily","KOG1080,Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases;COG2940,Proteins containing SET domain","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0016740,molecular_function,transferase activity;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0005829,cellular_component,cytosol;GO:0032259,biological_process,methylation;GO:0051568,biological_process,histone H3-K4 methylation;GO:0005634,cellular_component,nucleus;GO:0048188,cellular_component,Set1C/COMPASS complex;GO:0005654,cellular_component,nucleoplasm","-"]
["MAST2",9.767308248,2.038277112,2.258166527,5.571766957,{"v":5.64e-15,"d":"5.64E-15"},{"v":1.73e-13,"d":"1.73E-13"},"ENSG00000086015","K7BU88,Microtubule associated serine/threonine kinase 2","-","PF00069,Protein kinase domain;PF08926,omain of unknown function (DUF1908);PF00595,PDZ domain (Also known as DHR or GLGF)","IPR028779,Microtubule-associated serine/threonine-protein kinase 2;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR015022,Microtubule-associated serine/threonine-protein kinase, domain;IPR037711,Microtubule-associated serine/threonine-protein kinase, catalytic domain;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR008271,Serine/threonine-protein kinase, active site;IPR023142,Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily;IPR000719,Protein kinase domain","KOG0606,Microtubule-associated serine/threonine kinase and related proteins;ENOG410XPWX,-","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0045075,biological_process,regulation of interleukin-12 biosynthetic process;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0000287,molecular_function,magnesium ion binding","-"]
["RP11-386G11.10",344.8410198,72.07792695,2.25796812,8.415043782,1.95E-23,{"v":2.75e-21,"d":"2.75E-21"},"ENSG00000258017","A0A226N0Z0,Uncharacterized protein","-","-","IPR003008,Tubulin/FtsZ, GTPase domain;IPR008280,Tubulin/FtsZ, C-terminal;IPR036525,Tubulin/FtsZ, GTPase domain superfamily;IPR037103,Tubulin/FtsZ, C-terminal domain superfamily;IPR018316,Tubulin/FtsZ, 2-layer sandwich domain;IPR002452,Alpha tubulin;IPR000217,Tubulin;IPR023123,Tubulin, C-terminal","-","GO:0005874,cellular_component,microtubule;GO:0005525,molecular_function,GTP binding;GO:0007010,biological_process,cytoskeleton organization;GO:0007017,biological_process,microtubule-based process;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005200,molecular_function,structural constituent of cytoskeleton","-"]
["HTT",3.117581343,0.650699692,2.257038172,5.13750802,{"v":6.11e-13,"d":"6.11E-13"},{"v":1.16e-11,"d":"1.16E-11"},"ENSG00000197386","H2PCR6,Huntingtin","-","PF12372,Huntingtin protein region","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR028426,Huntingtin family;IPR000091,Huntingtin;IPR024613,Huntingtin, middle-repeat","ENOG410XSEC,-","GO:0005770,cellular_component,late endosome;GO:0030659,cellular_component,cytoplasmic vesicle membrane;GO:0032991,cellular_component,protein-containing complex;GO:0000132,biological_process,establishment of mitotic spindle orientation;GO:0042297,biological_process,vocal learning;GO:0005783,cellular_component,endoplasmic reticulum;GO:0006890,biological_process,retrograde vesicle-mediated transport, Golgi to ER;GO:0031072,molecular_function,heat shock protein binding;GO:0005634,cellular_component,nucleus;GO:0034452,molecular_function,dynactin binding;GO:0005794,cellular_component,Golgi apparatus;GO:0005737,cellular_component,cytoplasm;GO:0048487,molecular_function,beta-tubulin binding;GO:0005776,cellular_component,autophagosome;GO:1903599,biological_process,positive regulation of autophagy of mitochondrion;GO:0019900,molecular_function,kinase binding;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0007030,biological_process,Golgi organization;GO:0005522,molecular_function,profilin binding;GO:0016234,cellular_component,inclusion body;GO:0030425,cellular_component,dendrite;GO:1905337,biological_process,positive regulation of aggrephagy;GO:0030424,cellular_component,axon;GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0005814,cellular_component,centriole;GO:0005654,cellular_component,nucleoplasm;GO:1904504,biological_process,positive regulation of lipophagy;GO:0047496,biological_process,vesicle transport along microtubule;GO:0044325,molecular_function,ion channel binding;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0045505,molecular_function,dynein intermediate chain binding;GO:0045724,biological_process,positive regulation of cilium assembly;GO:0031648,biological_process,protein destabilization;GO:2001237,biological_process,negative regulation of extrinsic apoptotic signaling pathway;GO:0002039,molecular_function,p53 binding;GO:0031587,biological_process,positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0043065,biological_process,positive regulation of apoptotic process","-"]
["TTLL12",13.56327961,2.835685375,2.254944764,5.283554456,{"v":1.46e-13,"d":"1.46E-13"},{"v":3.2e-12,"d":"3.20E-12"},"ENSG00000100304","A0A024R4U3,Tubulin tyrosine ligase-like family, member 12, isoform CRA_a","NP_055955.1,tubulin--tyrosine ligase-like protein 12","PF03133,Tubulin-tyrosine ligase family","IPR027749,Tubulin--tyrosine ligase-like protein 12;IPR013815,ATP-grasp fold, subdomain 1;IPR004344,Tubulin-tyrosine ligase/Tubulin polyglutamylase","ENOG410XQ0A,-;KOG2155,Tubulin-tyrosine ligase-related protein","GO:0005524,molecular_function,ATP binding;GO:0016874,molecular_function,ligase activity;GO:0006464,biological_process,cellular protein modification process","-"]
["TUG1",32.02024041,6.70472823,2.254871769,7.051380596,{"v":2.6e-20,"d":"2.60E-20"},2.24E-18,"ENSG00000253352","A0A024R1L7,HCG41307, isoform CRA_a","-","-","-","-","-","-"]
["RAI1",35.15478268,7.369300632,2.253572057,7.694978423,{"v":5.48e-22,"d":"5.48E-22"},{"v":6.29e-20,"d":"6.29E-20"},"ENSG00000108557","H2QCD6,Retinoic acid induced 1","XP_001159372.1,retinoic acid-induced protein 1 isoform X3","PF13771,PHD-like zinc-binding domain","IPR034732,Extended PHD (ePHD) domain;IPR001965,Zinc finger, PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410Z8S8,-;ENOG410IJJX,-","GO:0032922,biological_process,circadian regulation of gene expression;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus","-"]
["FAM217B",7.360684571,1.538904025,2.253154155,4.62629251,1.04E-10,{"v":1.18e-09,"d":"1.18E-09"},"ENSG00000196227","H2QKP6,Chromosome 20 open reading frame 177","XP_003953840.1,-;XP_009435802.1,-","PF15344,AM217 family","IPR029266,FAM217 family","ENOG410IVFB,-;ENOG4112055,-","GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm","-"]
["KLHL28",1.176127515,0.243434952,2.252614741,2.713936234,1.84687E-4,5.28762E-4,"ENSG00000179454","G3QYI6,Kelch like family member 28","XP_004055165.1,-","PF01344,Kelch motif;PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch","IPR011705,BTB/Kelch-associated;IPR011333,SKP1/BTB/POZ domain superfamily;IPR015915,Kelch-type beta propeller;IPR017096,BTB-kelch protein;IPR011043,Galactose oxidase/kelch, beta-propeller;IPR030569,Kelch-like protein 28;IPR006652,Kelch repeat type 1;IPR000210,BTB/POZ domain","-","-","-"]
["RP4-756G23.5",3.799362325,0.786392268,2.252614741,2.713936234,1.84687E-4,5.28762E-4,"ENSG00000235513","H0Y5M2,Lethal","-","PF02820,mbt repeat","IPR038038,Lethal(3)malignant brain tumor-like protein 2;IPR004092,Mbt repeat","ENOG410ZYE4,-;ENOG410IMEW,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0035064,molecular_function,methylated histone binding;GO:0005634,cellular_component,nucleus","-"]
["FAM86EP",2.73256784,0.565587074,2.252614741,2.713936234,1.84687E-4,5.28762E-4,"ENSG00000251669","D3DVS0,HCG1981358, isoform CRA_c","-","-","-","-","-","-"]
["ZADH2",2.503564116,0.522204828,2.2521143,3.730794624,{"v":2.36E-7,"d":"2.36E-07"},{"v":1.27e-06,"d":"1.27E-06"},"ENSG00000180011","H2QEQ3,Zinc binding alcohol dehydrogenase domain containing 2","XP_001138011.1,zinc-binding alcohol dehydrogenase domain-containing protein 2 isoform X1","PF00107,Zinc-binding dehydrogenase;PF08240,Alcohol dehydrogenase GroES-like domain;PF13602,Zinc-binding dehydrogenase","IPR020843,Polyketide synthase, enoylreductase domain;IPR036291,NAD(P)-binding domain superfamily;IPR013149,Alcohol dehydrogenase, C-terminal;IPR002364,Quinone oxidoreductase/zeta-crystallin, conserved site;IPR013154,Alcohol dehydrogenase, N-terminal;IPR011032,GroES-like superfamily","COG2130,Putative NADP-dependent oxidoreductases;ENOG410IQ9R,-","GO:0005777,cellular_component,peroxisome;GO:0016491,molecular_function,oxidoreductase activity;GO:0045599,biological_process,negative regulation of fat cell differentiation;GO:0036132,molecular_function,13-prostaglandin reductase activity;GO:0005739,cellular_component,mitochondrion;GO:0006693,biological_process,prostaglandin metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0008270,molecular_function,zinc ion binding","-"]
["EP300",14.11463104,2.962077544,2.251450985,6.752669254,2.19E-19,{"v":1.64e-17,"d":"1.64E-17"},"ENSG00000100393","K7CIV1,E1A binding protein p300","-","PF02172,KIX domain;PF02135,TAZ zinc finger;PF00569,Zinc finger, ZZ type;PF00439,Bromodomain;PF08214,Histone acetylation protein;PF09030,Creb binding;PF06001,omain of Unknown Function (DUF902)","IPR031162,CBP/p300-type histone acetyltransferase domain;IPR036529,Coactivator CBP, KIX domain superfamily;IPR018359,Bromodomain, conserved site;IPR036427,Bromodomain-like superfamily;IPR014744,Nuclear receptor coactivator, CREB-bp-like, interlocking;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR009110,Nuclear receptor coactivator, interlocking;IPR037073,Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily;IPR010303,CREB-binding protein/p300, atypical RING domain;IPR001487,Bromodomain;IPR035898,TAZ domain superfamily;IPR038547,CBP/p300, atypical RING domain superfamily;IPR000433,Zinc finger, ZZ-type;IPR013178,Histone acetyltransferase Rtt109/CBP;IPR000197,Zinc finger, TAZ-type;IPR003101,Coactivator CBP, KIX domain","KOG1778,CREB binding protein/P300 and related TAZ Zn-finger proteins;COG5076,Transcription factor involved in chromatin remodeling, contains bromodomain","GO:0004402,molecular_function,histone acetyltransferase activity;GO:0003712,molecular_function,transcription cofactor activity;GO:0003713,molecular_function,transcription coactivator activity;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0000123,cellular_component,histone acetyltransferase complex;GO:0016573,biological_process,histone acetylation;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["KDM6B",19.33575997,4.063062835,2.249302759,6.426438983,{"v":3.44e-18,"d":"3.44E-18"},2.03E-16,"ENSG00000132510","D3DTQ7,HCG2036579, isoform CRA_b","-","PF02373,JmjC domain, hydroxylase","IPR029518,Lysine-specific demethylase 6B;IPR003347,JmjC domain","KOG1246,DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain;KOG1124,FOG: TPR repeat;ENOG410XR9J,-","GO:0071557,biological_process,histone H3-K27 demethylation;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0071558,molecular_function,histone demethylase activity (H3-K27 specific)","-"]
["SP2",14.32152627,3.005251164,2.249005957,5.009285735,{"v":2E-12,"d":"2.00E-12"},{"v":3.36e-11,"d":"3.36E-11"},"ENSG00000167182","H2NVG2,Sp2 transcription factor","XP_002834287.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR030451,Transcription factor Sp2;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0042826,molecular_function,histone deacetylase binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0035264,biological_process,multicellular organism growth;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["RTN4RL1",3.47183109,0.723119327,2.248510717,3.082745926,{"v":1.54e-05,"d":"1.54E-05"},{"v":5.62e-05,"d":"5.62E-05"},"ENSG00000185924","H2QBU8,Reticulon 4 receptor-like 1","XP_016786649.1,reticulon-4 receptor-like 1 isoform X1","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR000483,Cysteine-rich flanking region, C-terminal;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0009986,cellular_component,cell surface;GO:0010977,biological_process,negative regulation of neuron projection development;GO:0004860,molecular_function,protein kinase inhibitor activity;GO:0022038,biological_process,corpus callosum development;GO:0005737,cellular_component,cytoplasm;GO:0046426,biological_process,negative regulation of JAK-STAT cascade;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0035374,molecular_function,chondroitin sulfate binding;GO:0048681,biological_process,negative regulation of axon regeneration;GO:0008201,molecular_function,heparin binding;GO:0046658,cellular_component,anchored component of plasma membrane;GO:0004872,-,-","-"]
["ATP9A",3.197731907,0.66974613,2.248341299,4.091810579,{"v":1.44E-8,"d":"1.44E-08"},{"v":1.02E-7,"d":"1.02E-07"},"ENSG00000054793","H2QKK9,Phospholipid-transporting ATPase","-","PF13246,Cation transport ATPase (P-type);PF16209,Phospholipid-translocating ATPase N-terminal;PF00122,1-E2 ATPase;PF16212,Phospholipid-translocating P-type ATPase C-terminal","IPR032630,P-type ATPase, C-terminal;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR023299,P-type ATPase, cytoplasmic domain N;IPR018303,P-type ATPase, phosphorylation site;IPR006539,P-type ATPase, subfamily IV;IPR023298,P-type ATPase, transmembrane domain superfamily;IPR032631,P-type ATPase, N-terminal;IPR030356,Probable phospholipid-transporting ATPase IIA;IPR008250,P-type ATPase, A domain superfamily;IPR001757,P-type ATPase","KOG0210,P-type ATPase;ENOG410XPYK,-","GO:0016787,molecular_function,hydrolase activity;GO:0045332,biological_process,phospholipid translocation;GO:0005768,cellular_component,endosome;GO:0005524,molecular_function,ATP binding;GO:0005802,cellular_component,trans-Golgi network;GO:0005886,cellular_component,plasma membrane;GO:0000287,molecular_function,magnesium ion binding;GO:0006890,biological_process,retrograde vesicle-mediated transport, Golgi to ER;GO:0016020,cellular_component,membrane;GO:0015914,biological_process,phospholipid transport;GO:0004012,molecular_function,phospholipid-translocating ATPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0006897,biological_process,endocytosis;GO:0016021,cellular_component,integral component of membrane","-"]
["FST",13.67655266,2.869400327,2.248288695,4.676751549,{"v":6.23e-11,"d":"6.23E-11"},{"v":7.42e-10,"d":"7.42E-10"},"ENSG00000134363","H2QQV8,Follistatin","XP_003310757.1,-","PF07648,Kazal-type serine protease inhibitor domain;PF09289,ollistatin/Osteonectin-like EGF domain","IPR002350,Kazal domain;IPR015369,Follistatin/Osteonectin EGF domain;IPR003645,Follistatin-like, N-terminal;IPR036058,Kazal domain superfamily;IPR017878,TB domain;IPR036773,TGF-beta binding (TB) domain superfamily","ENOG410YM8Q,-;ENOG410IP0F,-","GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0032926,biological_process,negative regulation of activin receptor signaling pathway;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0048185,molecular_function,activin binding;GO:0051798,biological_process,positive regulation of hair follicle development","K04661,ko04350,TGF-beta signaling pathway"]
["SDAD1",28.56867975,6.007006727,2.247847945,5.940919826,{"v":2.37e-16,"d":"2.37E-16"},{"v":9.6e-15,"d":"9.60E-15"},"ENSG00000198301","H2QZJ2,Uncharacterized protein","XP_001152561.1,-","PF08158,NUC130/3NT domain;PF05285,SDA1","IPR016024,Armadillo-type fold;IPR007949,SDA1 domain;IPR012977,Uncharacterised domain NUC130/133, N-terminal;IPR027312,Sda1","KOG2229,Protein required for actin cytoskeleton organization and cell cycle progression;ENOG410XPHI,-","GO:0042273,biological_process,ribosomal large subunit biogenesis;GO:0030036,biological_process,actin cytoskeleton organization;GO:0000055,biological_process,ribosomal large subunit export from nucleus;GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus","-"]
["PRSS23",9.03259913,1.900308253,2.247149542,6.026298359,{"v":1.27e-16,"d":"1.27E-16"},{"v":5.45e-15,"d":"5.45E-15"},"ENSG00000150687","G3QSM7,Protease, serine 23","-","PF00089,Trypsin","-","-","-","-"]
["TTLL5",7.99535627,1.682928179,2.246291386,5.917336058,{"v":3.35e-16,"d":"3.35E-16"},{"v":1.33e-14,"d":"1.33E-14"},"ENSG00000119685","G3V2J9,Tubulin polyglutamylase TTLL5","-","PF03133,Tubulin-tyrosine ligase family","IPR013815,ATP-grasp fold, subdomain 1;IPR004344,Tubulin-tyrosine ligase/Tubulin polyglutamylase","ENOG410XQDM,-;KOG2157,Predicted tubulin-tyrosine ligase;KOG2156,Tubulin-tyrosine ligase-related protein","GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane;GO:0005524,molecular_function,ATP binding;GO:0006464,biological_process,cellular protein modification process","-"]
["GNG4",2.901753303,0.606671811,2.246025567,3.374911704,{"v":3.69e-06,"d":"3.69E-06"},{"v":1.55e-05,"d":"1.55E-05"},"ENSG00000168243","M3W570,Guanine nucleotide-binding protein subunit gamma","-","PF00631,L domain","-","-","-","-"]
["STRADB",4.834167054,1.010683051,2.246025567,3.374911704,{"v":3.69e-06,"d":"3.69E-06"},{"v":1.55e-05,"d":"1.55E-05"},"ENSG00000082146","A0A024R420,Amyotrophic lateral sclerosis 2","NP_061041.2,STE20-related kinase adapter protein beta isoform 1","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","ENOG410XSWS,-;KOG0582,Ste20-like serine/threonine protein kinase","GO:0000902,biological_process,cell morphogenesis;GO:0016235,cellular_component,aggresome;GO:0007254,biological_process,JNK cascade;GO:0004672,molecular_function,protein kinase activity;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:2001240,biological_process,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand","K17532,ko04152,AMPK signaling pathway;K17532,ko04150,mTOR signaling pathway"]
["RNF25",6.746607658,1.410518489,2.246025567,3.374911704,{"v":3.69e-06,"d":"3.69E-06"},{"v":1.55e-05,"d":"1.55E-05"},"ENSG00000163481","K7DIE8,Ring finger protein 25","-","PF05773,RWD domain","IPR001841,Zinc finger, RING-type;IPR006575,RWD domain;IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG4111H5K,-;KOG4445,Uncharacterized conserved protein, contains RWD domain","-","-"]
["SS18L1",3.076633213,0.643234089,2.246025567,3.374911704,{"v":3.69e-06,"d":"3.69E-06"},{"v":1.55e-05,"d":"1.55E-05"},"ENSG00000184402","K7CH13,Synovial sarcoma translocation gene on chromosome 18-like 1","XP_016793717.1,calcium-responsive transactivator isoform X1","PF05030,SSXT protein (N-terminal region)","IPR007726,SS18 family","KOG3227,Calcium-responsive transcription coactivator;ENOG41128HA,-","GO:0016358,biological_process,dendrite development;GO:0003713,molecular_function,transcription coactivator activity;GO:0000776,cellular_component,kinetochore;GO:0050775,biological_process,positive regulation of dendrite morphogenesis;GO:1903506,biological_process,regulation of nucleic acid-templated transcription;GO:0000780,cellular_component,condensed nuclear chromosome, centromeric region;GO:0005829,cellular_component,cytosol;GO:0071565,cellular_component,nBAF complex;GO:0005634,cellular_component,nucleus","-"]
["TMEM164",2.380733646,0.497741828,2.246025567,3.374911704,{"v":3.69e-06,"d":"3.69E-06"},{"v":1.55e-05,"d":"1.55E-05"},"ENSG00000157600","H2PWH2,Transmembrane protein 164","XP_002832037.1,-","PF14808,TMEM164 family","IPR026508,Transmembrane protein 164","ENOG410IHH4,-;ENOG4111FTI,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NAA60",12.96998133,2.731012931,2.245126246,5.502407369,{"v":1.91e-14,"d":"1.91E-14"},{"v":5.08e-13,"d":"5.08E-13"},"ENSG00000122390","F7HDL9,N","-","PF00583,Acetyltransferase (GNAT) family","IPR016181,Acyl-CoA N-acyltransferase;IPR000182,GNAT domain","KOG3138,Predicted N-acetyltransferase;COG0456,Acetyltransferases","GO:0017196,biological_process,N-terminal peptidyl-methionine acetylation;GO:0043967,biological_process,histone H4 acetylation;GO:0008283,biological_process,cell proliferation;GO:0042803,molecular_function,protein homodimerization activity;GO:0008080,molecular_function,N-acetyltransferase activity;GO:0010485,molecular_function,H4 histone acetyltransferase activity;GO:0000139,cellular_component,Golgi membrane;GO:0006474,biological_process,N-terminal protein amino acid acetylation;GO:0004596,molecular_function,peptide alpha-N-acetyltransferase activity;GO:0006334,biological_process,nucleosome assembly","-"]
["SRXN1",27.1081263,5.707999229,2.245126246,5.502407369,{"v":1.91e-14,"d":"1.91E-14"},{"v":5.08e-13,"d":"5.08E-13"},"ENSG00000271303","H2RI32,Sulfiredoxin","-","PF02195,ParB-like nuclease domain","-","-","-","-"]
["KIAA0196",15.28798594,3.219101572,2.245126246,5.502407369,{"v":1.91e-14,"d":"1.91E-14"},{"v":5.08e-13,"d":"5.08E-13"},"ENSG00000164961","H2R9P1,KIAA0196","XP_519952.2,-;XP_016815332.1,-","PF10266,Hereditary spastic paraplegia protein strumpellin","IPR019393,WASH complex, subunit strumpellin","KOG3666,Uncharacterized conserved protein;ENOG410XNSS,-","GO:0071203,cellular_component,WASH complex","-"]
["ZFAND3",18.88620085,3.978074531,2.244752041,5.5608435,{"v":9.1e-15,"d":"9.10E-15"},{"v":2.64e-13,"d":"2.64E-13"},"ENSG00000156639","H2PIX2,Zinc finger AN1-type containing 3","XP_002816882.1,-","PF01754,A20-like zinc finger;PF01428,AN1-like Zinc finger","IPR002653,Zinc finger, A20-type;IPR000058,Zinc finger, AN1-type;IPR035896,AN1-like Zinc finger","KOG3173,Predicted Zn-finger protein;ENOG4111UWC,-","GO:0003677,molecular_function,DNA binding;GO:0046872,molecular_function,metal ion binding;GO:0008270,molecular_function,zinc ion binding","-"]
["SGMS1",2.917926812,0.611597658,2.244359216,3.61700842,{"v":3.31e-07,"d":"3.31E-07"},{"v":1.72E-6,"d":"1.72E-06"},"ENSG00000198964","A0A0D9R3R5,Sphingomyelin synthase 1","XP_007961647.1,-;XP_007961646.1,-;XP_007961645.1,-","PF14360,PAP2 superfamily C-terminal","IPR025749,Sphingomyelin synthase-like domain;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","-","GO:0046513,biological_process,ceramide biosynthetic process;GO:0033188,molecular_function,sphingomyelin synthase activity;GO:0002950,molecular_function,ceramide phosphoethanolamine synthase activity;GO:2001237,biological_process,negative regulation of extrinsic apoptotic signaling pathway;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K04714,ko00600,Sphingolipid metabolism;K04714,ko04071,Sphingolipid signaling pathway"]
["ZMIZ1",14.33616192,3.025133182,2.243416725,6.599964103,{"v":9.23e-19,"d":"9.23E-19"},{"v":5.97e-17,"d":"5.97E-17"},"ENSG00000108175","K7BEX8,Zinc finger, MIZ-type containing 1","XP_016774218.1,-","PF02891,MIZ/SP-RING zinc finger","IPR004181,Zinc finger, MIZ-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XQ2E,-;KOG2169,Zn-finger transcription factor","GO:0008270,molecular_function,zinc ion binding","-"]
["YIPF1",10.52835343,2.210741316,2.243164235,3.82379278,{"v":1.08E-7,"d":"1.08E-07"},{"v":6.28e-07,"d":"6.28E-07"},"ENSG00000058799","G3RHA5,Protein YIPF","XP_018874422.1,-;XP_004025882.2,protein YIPF1","PF04893,Yip1 domain","IPR006977,Yip1 domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["FLRT2",0.625987374,0.13144469,2.243164235,3.82379278,{"v":1.08E-7,"d":"1.08E-07"},{"v":6.28e-07,"d":"6.28E-07"},"ENSG00000185070","F7HYC2,Fibronectin leucine rich transmembrane protein 2","XP_002754220.1,leucine-rich repeat transmembrane protein FLRT2","PF01463,Leucine rich repeat C-terminal domain;PF00041,ibronectin type III domain;PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR003961,Fibronectin type III;IPR000483,Cysteine-rich flanking region, C-terminal;IPR036116,Fibronectin type III superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR000372,Leucine-rich repeat N-terminal domain;IPR003591,Leucine-rich repeat, typical subtype;IPR013783,Immunoglobulin-like fold","ENOG4111ID7,-;ENOG410IHC8,-","GO:0005104,molecular_function,fibroblast growth factor receptor binding;GO:0003007,biological_process,heart morphogenesis;GO:0061343,biological_process,cell adhesion involved in heart morphogenesis;GO:0007411,biological_process,axon guidance;GO:0050919,biological_process,negative chemotaxis;GO:0005911,cellular_component,cell-cell junction;GO:2001222,biological_process,regulation of neuron migration;GO:0008543,biological_process,fibroblast growth factor receptor signaling pathway;GO:0071711,biological_process,basement membrane organization;GO:0016020,cellular_component,membrane;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0045499,molecular_function,chemorepellent activity;GO:0005925,cellular_component,focal adhesion;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space","-"]
["NFIC",25.55738806,5.398541836,2.242322804,7.187691384,{"v":1.7e-20,"d":"1.70E-20"},{"v":1.53e-18,"d":"1.53E-18"},"ENSG00000141905","A0A0A0MWM6,Nuclear factor 1","XP_003914699.1,nuclear factor 1 C-type isoform X4","PF00859,CTF/NF-I family transcription modulation region;PF03165,MH1 domain;PF10524,Nuclear factor I protein pre-N-terminus","IPR020604,CTF transcription factor/nuclear factor 1, DNA-binding domain;IPR000647,CTF transcription factor/nuclear factor 1;IPR003619,MAD homology 1, Dwarfin-type;IPR019548,CTF transcription factor/nuclear factor 1, N-terminal;IPR019739,CTF transcription factor/nuclear factor 1, conserved site","-","GO:0003677,molecular_function,DNA binding;GO:0006260,biological_process,DNA replication;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","-"]
["FAM120A",68.1989229,14.41828319,2.241472631,8.222609884,{"v":8.18e-23,"d":"8.18E-23"},{"v":1.04e-20,"d":"1.04E-20"},"ENSG00000048828","H2QXH4,Family with sequence similarity 120A","-","-","IPR026784,Constitutive coactivator of PPAR-gamma;IPR029060,PIN-like domain superfamily","ENOG410XPY7,-;ENOG410IE6R,-","GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["KCMF1",18.26845746,3.86550751,2.239354825,6.480226217,{"v":3.17e-18,"d":"3.17E-18"},{"v":1.89e-16,"d":"1.89E-16"},"ENSG00000176407","H9FXB2,E3 ubiquitin-protein ligase KCMF1","-","PF00569,Zinc finger, ZZ type;PF05605,rought induced 19 protein (Di19), zinc-binding","IPR013087,Zinc finger C2H2-type;IPR000433,Zinc finger, ZZ-type;IPR008598,Drought induced 19 protein type, zinc-binding domain","KOG1280,Uncharacterized conserved protein containing ZZ-type Zn-finger;ENOG410XRX5,-","GO:0008270,molecular_function,zinc ion binding;GO:0003676,molecular_function,nucleic acid binding;GO:0016874,molecular_function,ligase activity;GO:0046872,molecular_function,metal ion binding","-"]
["2020-03-07",16.99380811,3.595543529,2.238997302,6.040350113,{"v":1.18e-16,"d":"1.18E-16"},{"v":5.12e-15,"d":"5.12E-15"},"ENSG00000136536","H2QIV6,Membrane-associated ring finger","XP_009441751.1,E3 ubiquitin-protein ligase MARCH7 isoform X3;XP_009441752.1,-","PF12906,RING-variant domain","IPR011016,Zinc finger, RING-CH-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG1609,Protein involved in mRNA turnover and stability;COG5183,Protein involved in mRNA turnover and stability","GO:0008270,molecular_function,zinc ion binding","-"]
["RP11-302M6.4",80.60573739,17.03449103,2.23891483,5.042846914,1.33E-12,2.35E-11,"ENSG00000271949","H2R8W4,Leucine rich repeat containing 8 family member C","-","PF12534,Pannexin-like TM region of LRRC8","-","-","-","-"]
["NCOA3",18.59661695,3.938825036,2.238020999,6.581497043,1.38E-18,{"v":8.76e-17,"d":"8.76E-17"},"ENSG00000124151","A8K0W8,cDNA FLJ77005, highly similar to Homo sapiens nuclear receptor coactivator 3","-","PF07469,omain of unknown function (DUF1518);PF16279,omain of unknown function (DUF4927);PF14598,PAS domain;PF00989,PAS fold;PF08815,Nuclear receptor coactivator;PF08832,Steroid receptor coactivator;PF16665,Unstructured region on nuclear receptor coactivator protein","IPR014920,Nuclear receptor coactivator, Ncoa-type, interlocking;IPR000014,PAS domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR009110,Nuclear receptor coactivator, interlocking;IPR028818,Nuclear receptor coactivator 3;IPR035965,PAS domain superfamily;IPR037077,Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily;IPR032565,Domain of unknown function DUF4927;IPR013767,PAS fold;IPR017426,Nuclear receptor coactivator;IPR014935,Nuclear receptor coactivator, receptor-binding domain;IPR010011,Domain of unknown function DUF1518","ENOG410IQ5R,-;ENOG410ZDZC,-","GO:0046983,molecular_function,protein dimerization activity;GO:0003713,molecular_function,transcription coactivator activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0035257,molecular_function,nuclear hormone receptor binding;GO:0005634,cellular_component,nucleus;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity","-"]
["LRRC8D",37.29279281,7.901200139,2.237732808,6.791082361,{"v":2.81e-19,"d":"2.81E-19"},{"v":2.03e-17,"d":"2.03E-17"},"ENSG00000171492","B3KRU1,cDNA FLJ34919 fis, clone NT2RP7002779, highly similar to Leucine-rich repeat-containing protein 8D","NP_001127951.1,-","PF13855,Leucine rich repeat;PF12534,Pannexin-like TM region of LRRC8","IPR001611,Leucine-rich repeat;IPR021040,LRRC8, pannexin-like TM region;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["INTS6",2.969531787,0.629405653,2.23573925,5.553514381,1.07E-14,{"v":3.06e-13,"d":"3.06E-13"},"ENSG00000102786","A0A024RDU0,Integrator complex subunit 6, isoform CRA_d","NP_036273.1,integrator complex subunit 6 isoform a;XP_011533342.1,-","PF15300,INTS6/SAGE1/DDX26B/CT45 C-terminus;PF13519,von Willebrand factor type A domain","IPR029307,INTS6/SAGE1/DDX26B/CT45, C-terminal;IPR002035,von Willebrand factor, type A;IPR036465,von Willebrand factor A-like domain superfamily","ENOG410XRER,-;KOG3768,DEAD box RNA helicase","GO:0015629,cellular_component,actin cytoskeleton;GO:0005654,cellular_component,nucleoplasm","-"]
["CHST3",5.110333112,1.081242358,2.235546652,4.49678397,{"v":3.23e-10,"d":"3.23E-10"},{"v":3.33e-09,"d":"3.33E-09"},"ENSG00000122863","G3R9M0,Sulfotransferase","-","PF00685,Sulfotransferase domain","-","-","-","-"]
["ADPGK",5.48508513,1.160163943,2.235512179,4.371299843,{"v":1.32E-9,"d":"1.32E-09"},{"v":1.18E-8,"d":"1.18E-08"},"ENSG00000159322","K7CK11,ADP-dependent glucokinase","XP_016782647.1,-","PF04587,ADP-specific Phosphofructokinase/Glucokinase conserved region","IPR007666,ADP-specific phosphofructokinase/glucokinase;IPR029056,Ribokinase-like","KOG4184,Predicted sugar kinase;ENOG410Z7J9,-","GO:0005975,biological_process,carbohydrate metabolic process;GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0016773,molecular_function,phosphotransferase activity, alcohol group as acceptor","-"]
["UBR1",1.722112254,0.363043704,2.235153506,3.493295002,{"v":1.08E-6,"d":"1.08E-06"},{"v":5.06e-06,"d":"5.06E-06"},"ENSG00000159459","K7AI33,Ubiquitin protein ligase E3 component n-recognin 1","-","PF02207,Putative zinc finger in N-recognin (UBR box);PF02617,ATP-dependent Clp protease adaptor protein ClpS","IPR003769,Adaptor protein ClpS, core;IPR036390,Winged helix DNA-binding domain superfamily;IPR014719,Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like;IPR003126,Zinc finger, UBR-type","KOG1140,N-end rule pathway, recognition component UBR1;ENOG410XPQU,-","GO:0030163,biological_process,protein catabolic process;GO:0016874,molecular_function,ligase activity;GO:0008270,molecular_function,zinc ion binding","-"]
["SLC27A4",4.504870923,0.948222188,2.234987198,3.226902179,{"v":1.33E-5,"d":"1.33E-05"},{"v":4.94e-05,"d":"4.94E-05"},"ENSG00000167114","A0A024R8D2,Solute carrier family 27","NP_005085.2,long-chain fatty acid transport protein 4;XP_016869711.1,-","PF00501,AMP-binding enzyme;PF13193,AMP-binding enzyme C-terminal domain","IPR030304,Fatty acid transport protein 4;IPR000873,AMP-dependent synthetase/ligase;IPR025110,AMP-binding enzyme, C-terminal domain;IPR022272,Lipocalin family conserved site;IPR020845,AMP-binding, conserved site","ENOG410XQ8T,-;KOG1179,Very long-chain acyl-CoA synthetase/fatty acid transporter","GO:0006631,biological_process,fatty acid metabolic process;GO:0001676,biological_process,long-chain fatty acid metabolic process;GO:0001579,biological_process,medium-chain fatty acid transport;GO:0015908,biological_process,fatty acid transport;GO:0042760,biological_process,very long-chain fatty acid catabolic process;GO:0031526,cellular_component,brush border membrane;GO:0005902,cellular_component,microvillus;GO:0003824,molecular_function,catalytic activity;GO:0007584,biological_process,response to nutrient;GO:0004467,molecular_function,long-chain fatty acid-CoA ligase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0000038,biological_process,very long-chain fatty acid metabolic process;GO:0015909,biological_process,long-chain fatty acid transport;GO:0005886,cellular_component,plasma membrane;GO:0043588,biological_process,skin development;GO:0008152,biological_process,metabolic process;GO:0031957,molecular_function,very long-chain fatty acid-CoA ligase activity;GO:0016021,cellular_component,integral component of membrane","K08745,ko03320,PPAR signaling pathway;K08745,ko04931,Insulin resistance"]
["TMPRSS13",2.035246261,0.427360558,2.234727224,2.898413627,{"v":6.27e-05,"d":"6.27E-05"},1.99008E-4,"ENSG00000137747","J3KQC6,Transmembrane protease serine 13","-","PF00089,Trypsin;PF15494,Scavenger receptor cysteine-rich domain","IPR018114,Serine proteases, trypsin family, histidine active site;IPR017448,SRCR-like domain;IPR001254,Serine proteases, trypsin domain;IPR033116,Serine proteases, trypsin family, serine active site;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR009003,Peptidase S1, PA clan;IPR017327,Peptidase S1A, TMPRSS13;IPR001190,SRCR domain;IPR036772,SRCR-like domain superfamily;IPR001314,Peptidase S1A, chymotrypsin family","KOG3627,Trypsin;COG5640,Secreted trypsin-like serine protease","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0005044,molecular_function,scavenger receptor activity;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0008233,molecular_function,peptidase activity;GO:0016020,cellular_component,membrane;GO:0008236,molecular_function,serine-type peptidase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["TLN2",0.673645802,0.141451996,2.234727224,2.898413627,{"v":6.27e-05,"d":"6.27E-05"},1.99008E-4,"ENSG00000171914","H2Q9J8,Talin 2","-","PF01608,I/LWEQ domain;PF08913,Vinculin Binding Site;PF16511,N-terminal or F0 domain of Talin-head FERM;PF09379,RM N-terminal domain;PF09141,Talin, middle domain;PF00373,RM central domain","IPR019747,FERM conserved site;IPR019748,FERM central domain;IPR035964,I/LWEQ domain superfamily;IPR015224,Talin, central;IPR018979,FERM, N-terminal;IPR000299,FERM domain;IPR015009,Vinculin-binding site-containing domain;IPR036723,Alpha-catenin/vinculin-like superfamily;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR032425,Talin, N-terminal F0 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR036476,Talin, central domain superfamily;IPR029071,Ubiquitin-like domain superfamily;IPR011993,PH-like domain superfamily;IPR037438,Talin-1/2, rod-segment;IPR002558,I/LWEQ domain","KOG4261,Talin;ENOG410XQ0V,-","GO:0007155,biological_process,cell adhesion;GO:0001726,cellular_component,ruffle;GO:0005856,cellular_component,cytoskeleton;GO:0003779,molecular_function,actin binding;GO:0007016,biological_process,cytoskeletal anchoring at plasma membrane;GO:0051015,molecular_function,actin filament binding;GO:0005925,cellular_component,focal adhesion;GO:0005200,molecular_function,structural constituent of cytoskeleton","-"]
["NFATC1",1.204583887,0.252938257,2.234727224,2.898413627,{"v":6.27e-05,"d":"6.27E-05"},1.99008E-4,"ENSG00000131196","K7BA43,Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1","-","PF00554,Rel homology DNA-binding domain;PF16179,Rel homology dimerisation domain","IPR011539,Rel homology domain (RHD), DNA-binding domain;IPR008967,p53-like transcription factor, DNA-binding;IPR032397,Rel homology dimerisation domain;IPR008366,Nuclear factor of activated T cells (NFAT);IPR037059,Rel homology domain (RHD), DNA-binding domain superfamily;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set;IPR002909,IPT domain;IPR015647,Nuclear factor of activated T-cells 1","ENOG41105U2,-;ENOG410IHFR,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding","-"]
["MFSD9",2.501297615,0.525221918,2.234727224,2.898413627,{"v":6.27e-05,"d":"6.27E-05"},1.99008E-4,"ENSG00000135953","A8K3H4,cDNA FLJ77980","-","-","IPR036259,MFS transporter superfamily;IPR001958,Tetracycline resistance protein TetA/multidrug resistance protein MdtG;IPR020846,Major facilitator superfamily domain;IPR011701,Major facilitator superfamily;IPR005829,Sugar transporter, conserved site","ENOG410XSE0,-;KOG2615,Permease of the major facilitator superfamily","GO:0055085,biological_process,transmembrane transport;GO:0005215,molecular_function,transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF774",0.920712583,0.192494093,2.234263435,2.469312679,0.000857787,0.00210112,"ENSG00000196391","H2R1B3,Zinc finger protein 774","XP_523156.2,zinc finger protein 774;XP_009428105.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["CYP2F2P",7.42062954,1.551436766,2.234263435,2.469312679,0.000857787,0.00210112,"ENSG00000237118","A0A024R0P5,Cytochrome P450, family 2, subfamily F, polypeptide 1, isoform CRA_a","-","PF00067,Cytochrome P450","IPR001128,Cytochrome P450;IPR002401,Cytochrome P450, E-class, group I;IPR036396,Cytochrome P450 superfamily;IPR020469,Cytochrome P450, CYP2 family;IPR017972,Cytochrome P450, conserved site","COG2124,Cytochrome P450;KOG0156,Cytochrome P450 CYP2 subfamily","GO:0019825,molecular_function,oxygen binding;GO:0016705,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0046872,molecular_function,metal ion binding;GO:0004497,molecular_function,monooxygenase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0005506,molecular_function,iron ion binding;GO:0055114,biological_process,oxidation-reduction process;GO:0020037,molecular_function,heme binding","-"]
["CACNA1D",0.38061904,0.079576318,2.234263435,2.469312679,0.000857787,0.00210112,"ENSG00000157388","G3QM72,Voltage-dependent L-type calcium channel subunit alpha","-","PF16885,Voltage-gated calcium channel subunit alpha, C-term;PF08763,Voltage gated calcium channel IQ domain;PF00520,Ion transport protein;PF16905,Voltage-dependent L-type calcium channel, IQ-associated","IPR002077,Voltage-dependent calcium channel, alpha-1 subunit;IPR014873,Voltage-dependent calcium channel, alpha-1 subunit, IQ domain;IPR005446,Voltage-dependent calcium channel, L-type, alpha-1 subunit;IPR031649,Voltage-dependent L-type calcium channel, IQ-associated domain;IPR027359,Voltage-dependent channel domain superfamily;IPR005821,Ion transport domain;IPR005452,Voltage-dependent calcium channel, L-type, alpha-1D subunit;IPR031688,Voltage-gated calcium channel subunit alpha, C-terminal","-","GO:0005216,molecular_function,ion channel activity;GO:0005262,molecular_function,calcium channel activity;GO:0055085,biological_process,transmembrane transport;GO:0005891,cellular_component,voltage-gated calcium channel complex;GO:0005245,molecular_function,voltage-gated calcium channel activity;GO:0006811,biological_process,ion transport;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0016020,cellular_component,membrane;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0006816,biological_process,calcium ion transport;GO:0016021,cellular_component,integral component of membrane;GO:0070588,biological_process,calcium ion transmembrane transport","-"]
["PXYLP1",0.58808141,0.122950636,2.234263435,2.469312679,0.000857787,0.00210112,"ENSG00000155893","G3QH82,2-phosphoxylose phosphatase 1","XP_018879685.1,2-phosphoxylose phosphatase 1 isoform X1","PF00328,Histidine phosphatase superfamily (branch 2)","IPR000560,Histidine phosphatase superfamily, clade-2;IPR029033,Histidine phosphatase superfamily","-","GO:0005794,cellular_component,Golgi apparatus;GO:0006024,biological_process,glycosaminoglycan biosynthetic process;GO:0010909,biological_process,positive regulation of heparan sulfate proteoglycan biosynthetic process;GO:0016311,biological_process,dephosphorylation;GO:0050650,biological_process,chondroitin sulfate proteoglycan biosynthetic process;GO:0016791,molecular_function,phosphatase activity","-"]
["PRR16",3.445991554,0.720456124,2.234263435,2.469312679,0.000857787,0.00210112,"ENSG00000184838","G7P842,Uncharacterized protein","-","PF15252,omain of unknown function (DUF4589)","IPR027997,Protein of unknown function DUF4589","-","-","-"]
["SLC19A2",1.293708228,0.267771816,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000117479","H2Q0K3,Solute carrier family 19","XP_524958.2,-","PF01770,Reduced folate carrier","IPR036259,MFS transporter superfamily;IPR002666,Reduced folate carrier;IPR028338,Thiamine transporter 1","ENOG410XT34,-;KOG3810,Micronutrient transporters (folate transporter family)","GO:0015234,molecular_function,thiamine transmembrane transporter activity;GO:0071934,biological_process,thiamine transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0090482,molecular_function,vitamin transmembrane transporter activity;GO:0015888,biological_process,thiamine transport;GO:0016021,cellular_component,integral component of membrane;GO:0051180,biological_process,vitamin transport","-"]
["ZNF487",0.954421806,0.197546289,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000243660","H2NA79,Zinc finger protein 487","XP_009243598.1,putative zinc finger protein 487","-","IPR001909,Krueppel-associated box;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0005622,cellular_component,intracellular","-"]
["SLC41A2",0.921996293,0.190834854,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000136052","H2Q6R7,Solute carrier family 41, member 2","XP_009424410.1,-;XP_009424413.1,-;XP_016779575.1,-;XP_009424411.1,-;XP_009424409.1,-;XP_009424408.1,-","PF01769,ivalent cation transporter","IPR036739,SLC41 divalent cation transporters, integral membrane domain superfamily;IPR006667,SLC41 divalent cation transporters, integral membrane domain","ENOG410XSTG,-;KOG3788,Predicted divalent cation transporter","GO:0098655,biological_process,cation transmembrane transport;GO:0055085,biological_process,transmembrane transport;GO:0008324,molecular_function,cation transmembrane transporter activity;GO:0006812,biological_process,cation transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0072509,molecular_function,divalent inorganic cation transmembrane transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0070838,biological_process,divalent metal ion transport","-"]
["SLC15A4",0.864119888,0.178855592,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000139370","H2Q769,Uncharacterized protein","XP_016780109.1,solute carrier family 15 member 4 isoform X1","PF00854,POT family","IPR036259,MFS transporter superfamily;IPR018456,PTR2 family proton/oligopeptide symporter, conserved site;IPR000109,Proton-dependent oligopeptide transporter family","KOG1237,H+/oligopeptide symporter;COG3104,Dipeptide/tripeptide permease","GO:0022857,molecular_function,transmembrane transporter activity;GO:0055085,biological_process,transmembrane transport;GO:0006857,biological_process,oligopeptide transport;GO:0016020,cellular_component,membrane;GO:0005215,molecular_function,transporter activity;GO:0016021,cellular_component,integral component of membrane","-"]
["SLC27A2",1.694933228,0.350817393,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000140284","Q53GS2,Solute carrier family 27","-","PF00501,AMP-binding enzyme;PF13193,AMP-binding enzyme C-terminal domain","IPR025110,AMP-binding enzyme, C-terminal domain;IPR000873,AMP-dependent synthetase/ligase;IPR030305,Fatty acid transport protein 2;IPR020845,AMP-binding, conserved site","ENOG410XQ8T,-;KOG1179,Very long-chain acyl-CoA synthetase/fatty acid transporter","GO:0001676,biological_process,long-chain fatty acid metabolic process;GO:0015908,biological_process,fatty acid transport;GO:0003824,molecular_function,catalytic activity;GO:0004467,molecular_function,long-chain fatty acid-CoA ligase activity;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0031957,molecular_function,very long-chain fatty acid-CoA ligase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["RP11-961A15.1",10.34684729,2.141591144,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000262791","G3RYD5,WD repeat domain 81","-","PF00400,WD domain, G-beta repeat;PF02138,Beige/BEACH domain","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","-","-","-"]
["ALOX12B",1.788103504,0.370101783,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000179477","H2QC68,Uncharacterized protein","XP_511864.2,arachidonate 12-lipoxygenase, 12R-type","PF00305,Lipoxygenase;PF01477,PLAT/LH2 domain","IPR020834,Lipoxygenase, conserved site;IPR036392,PLAT/LH2 domain superfamily;IPR001024,PLAT/LH2 domain;IPR036226,Lipoxigenase, C-terminal domain superfamily;IPR020833,Lipoxygenase, iron binding site;IPR013819,Lipoxygenase, C-terminal;IPR001885,Lipoxygenase, mammalian;IPR000907,Lipoxygenase","ENOG410YN4N,-;ENOG410IF0U,-","GO:0070257,biological_process,positive regulation of mucus secretion;GO:0006665,biological_process,sphingolipid metabolic process;GO:0043651,biological_process,linoleic acid metabolic process;GO:0010628,biological_process,positive regulation of gene expression;GO:0061436,biological_process,establishment of skin barrier;GO:0004052,molecular_function,arachidonate 12-lipoxygenase activity;GO:0016702,molecular_function,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0019369,biological_process,arachidonic acid metabolic process;GO:0003824,molecular_function,catalytic activity;GO:0046513,biological_process,ceramide biosynthetic process;GO:0046872,molecular_function,metal ion binding;GO:0006497,biological_process,protein lipidation;GO:0016491,molecular_function,oxidoreductase activity;GO:0005506,molecular_function,iron ion binding;GO:0055114,biological_process,oxidation-reduction process;GO:0019372,biological_process,lipoxygenase pathway;GO:1990136,molecular_function,linoleate 9S-lipoxygenase activity;GO:0043410,biological_process,positive regulation of MAPK cascade;GO:0051213,molecular_function,dioxygenase activity","K08021,ko00590,Arachidonic acid metabolism;K08021,ko04726,Serotonergic synapse"]
["AC010761.10",16.54774532,3.425053433,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000265840","F6SA91,TNF receptor-associated factor 4","-","PF02176,TRAF-type zinc finger;PF00097,Zinc finger, C3HC4 type (RING finger)","IPR008974,TRAF-like;IPR001293,Zinc finger, TRAF-type;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR018957,Zinc finger, C3HC4 RING-type;IPR012227,TNF receptor-associated factor TRAF;IPR027138,TNF receptor-associated factor 4;IPR017907,Zinc finger, RING-type, conserved site","KOG0297,TNF receptor-associated factor;ENOG410Z7YX,-","GO:0007250,biological_process,activation of NF-kappaB-inducing kinase activity;GO:0042981,biological_process,regulation of apoptotic process;GO:0046872,molecular_function,metal ion binding;GO:0008270,molecular_function,zinc ion binding;GO:0005622,cellular_component,intracellular;GO:0046330,biological_process,positive regulation of JNK cascade;GO:0007165,biological_process,signal transduction","-"]
["LRRC37A3",0.621542063,0.128646818,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000176809","A0A0G2JNC9,Leucine-rich repeat-containing protein 37A","-","PF14914,LRRC37A/B like protein 1 C-terminal domain;PF13855,Leucine rich repeat;PF15779,Leucine-rich repeat-containing protein 37 family","IPR001611,Leucine-rich repeat;IPR032754,Leucine-rich repeat-containing protein 37, N-terminal;IPR032675,Leucine-rich repeat domain superfamily;IPR029423,LRRC37A/B like protein 1, C-terminal;IPR003591,Leucine-rich repeat, typical subtype;IPR015753,Leucine-rich repeat-containing protein 37","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-78I14.1",9.935570932,2.056465136,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000273090","H2QHR0,Cysteine rich transmembrane BMP regulator 1","-","PF00093,von Willebrand factor type C domain;PF02822,Antistasin family","IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011061,Hirudin/antistatin;IPR001007,VWFC domain;IPR000867,Insulin-like growth factor-binding protein, IGFBP;IPR004094,Antistasin-like domain","KOG1216,von Willebrand factor and related coagulation proteins;ENOG410XNSK,-","GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0001558,biological_process,regulation of cell growth;GO:0004867,molecular_function,serine-type endopeptidase inhibitor activity;GO:0043086,biological_process,negative regulation of catalytic activity;GO:0004857,molecular_function,enzyme inhibitor activity;GO:0005520,molecular_function,insulin-like growth factor binding;GO:0005576,cellular_component,extracellular region","-"]
["CARF",0.54993086,0.113824726,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000138380","A0A024R427,Amyotrophic lateral sclerosis 2","NP_079020.13,calcium-responsive transcription factor isoform 1;NP_001098056.1,-;XP_005246916.1,-;NP_001309357.1,-;XP_016860450.1,-;XP_005246915.1,-;XP_011510169.1,-;NP_001309356.1,-","PF15299,Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8","IPR029309,Calcium-responsive transcription factor","ENOG410XRIT,-;ENOG410II1S,-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0005730,cellular_component,nucleolus;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["YPEL1",1.007681499,0.208569984,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000100027","A0A2D0PLK1,protein yippee-like 1","XP_017307478.1,protein yippee-like 1","-","IPR034751,Yippee domain;IPR004910,Yippee/Mis18/Cereblon","-","GO:0046872,molecular_function,metal ion binding","-"]
["DLG1-AS1",2.803543628,0.580277648,2.233201619,1.848165349,0.010399363,0.019654368,"-","-","-","-","-","-","-","-"]
["ZNRF2P2",5.35423101,1.108219093,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000225264","G3S4U6,Uncharacterized protein","-","-","-","-","-","-"]
["OR2A1-AS1",1.019361001,0.210987408,2.233201619,1.848165349,0.010399363,0.019654368,"-","-","-","-","-","-","-","-"]
["PCAT1",2.051491536,0.424617855,2.233201619,1.848165349,0.010399363,0.019654368,"ENSG00000253438","W5Q287,Uncharacterized protein","-","PF01359,Transposase (partial DDE domain)","IPR001888,Transposase, type 1;IPR036388,Winged helix-like DNA-binding domain superfamily","-","-","-"]
["ZFP36L2",13.36355796,2.836912944,2.23218718,4.952722327,{"v":4.61e-12,"d":"4.61E-12"},{"v":7.11e-11,"d":"7.11E-11"},"ENSG00000152518","K7CC74,Zinc finger protein 36, C3H type-like 2","XP_515435.2,zinc finger protein 36, C3H1 type-like 2","PF04553,Tis11B like protein, N terminus;PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type;IPR007635,Tis11B-like protein, N-terminal","-","GO:0046872,molecular_function,metal ion binding","-"]
["AKAP10",46.38505726,9.867752265,2.232049875,7.102923612,{"v":3.76e-20,"d":"3.76E-20"},{"v":3.14e-18,"d":"3.14E-18"},"ENSG00000108599","A0A0S2Z4Z7,A kinase anchor protein 10 isoform 1","NP_009133.2,A-kinase anchor protein 10, mitochondrial isoform 1 precursor","PF00615,Regulator of G protein signaling domain","IPR037719,A-kinase anchor protein 10, PKA-binding (AKB) domain;IPR036305,RGS domain superfamily;IPR016137,RGS domain","-","GO:0016301,molecular_function,kinase activity;GO:0008104,biological_process,protein localization;GO:0005886,cellular_component,plasma membrane;GO:0005739,cellular_component,mitochondrion;GO:0051018,molecular_function,protein kinase A binding;GO:0005829,cellular_component,cytosol;GO:0016310,biological_process,phosphorylation","-"]
["FAT1",24.55775626,5.225763048,2.23200284,7.919005964,3.93E-22,{"v":4.63e-20,"d":"4.63E-20"},"ENSG00000083857","A0A087WVP1,Protocadherin Fat 1","-","PF00008,-like domain;PF02210,Laminin G domain;PF00028,Cadherin domain","IPR002126,Cadherin;IPR015919,Cadherin-like;IPR018097,EGF-like calcium-binding, conserved site;IPR001791,Laminin G domain;IPR001881,EGF-like calcium-binding domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR020894,Cadherin conserved site","KOG1219,Uncharacterized conserved protein, contains laminin, cadherin and EGF domains;ENOG410XPEI,-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["SLC29A3",17.25213425,3.662408104,2.231939492,4.862526308,{"v":1.71e-11,"d":"1.71E-11"},{"v":2.34e-10,"d":"2.34E-10"},"ENSG00000198246","H2R251,Solute carrier family 29","XP_521506.4,equilibrative nucleoside transporter 3 isoform X2","PF01733,Nucleoside transporter","IPR002259,Equilibrative nucleoside transporter;IPR030193,Equilibrative nucleoside transporter 3","ENOG410Y3MT,-;KOG1479,Nucleoside transporter","GO:0005794,cellular_component,Golgi apparatus;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0015858,biological_process,nucleoside transport;GO:0005765,cellular_component,lysosomal membrane;GO:0005337,molecular_function,nucleoside transmembrane transporter activity;GO:0016020,cellular_component,membrane;GO:1901642,biological_process,nucleoside transmembrane transport;GO:0016021,cellular_component,integral component of membrane","-"]
["CHD9",4.388882821,0.93323124,2.231011813,5.490938997,2.64E-14,{"v":6.81e-13,"d":"6.81E-13"},"ENSG00000177200","B7ZML1,CHD9 protein","-","PF07533,BRK domain;PF00176,SNF2 family N-terminal domain;PF00385,Chromo (CHRromatin Organisation MOdifier) domain;PF00271,Helicase conserved C-terminal domain","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR023780,Chromo domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR016197,Chromo-like domain superfamily;IPR006576,BRK domain;IPR000953,Chromo/chromo shadow domain;IPR037259,BRK domain superfamily;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR001650,Helicase, C-terminal","COG0553,Superfamily II DNA/RNA helicases, SNF2 family;KOG0384,Chromodomain-helicase DNA-binding protein","GO:0016817,molecular_function,hydrolase activity, acting on acid anhydrides;GO:0005634,cellular_component,nucleus;GO:0005524,molecular_function,ATP binding","-"]
["TBC1D5",3.013293174,0.639683716,2.230499695,4.431387178,{"v":7.33e-10,"d":"7.33E-10"},{"v":6.95e-09,"d":"6.95E-09"},"ENSG00000131374","H2QM58,TBC1 domain family, member 5","XP_016795560.1,-;XP_009443274.1,-;XP_016795558.1,-;XP_009443270.1,TBC1 domain family member 5 isoform X1;XP_016795556.1,-;XP_009443272.1,-;XP_016795559.1,-;XP_009443271.1,-;XP_009443273.1,-;XP_016795557.1,-","PF00566,Rab-GTPase-TBC domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain","ENOG410YX8Z,-;KOG1091,Ypt/Rab-specific GTPase-activating protein GYP6","GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0030122,cellular_component,AP-2 adaptor complex;GO:0005096,molecular_function,GTPase activator activity;GO:0016236,biological_process,macroautophagy;GO:0005794,cellular_component,Golgi apparatus;GO:0017137,molecular_function,Rab GTPase binding;GO:0042594,biological_process,response to starvation;GO:0030904,cellular_component,retromer complex;GO:0005776,cellular_component,autophagosome;GO:0031338,biological_process,regulation of vesicle fusion;GO:1990316,cellular_component,Atg1/ULK1 kinase complex;GO:0002092,biological_process,positive regulation of receptor internalization;GO:0005829,cellular_component,cytosol;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:1905394,molecular_function,retromer complex binding;GO:0012505,cellular_component,endomembrane system;GO:0090630,biological_process,activation of GTPase activity;GO:0006914,biological_process,autophagy;GO:0035612,molecular_function,AP-2 adaptor complex binding;GO:0005622,cellular_component,intracellular;GO:0010008,cellular_component,endosome membrane;GO:0006886,biological_process,intracellular protein transport","-"]
["SEC16A",9.260350528,1.97090794,2.230220242,5.835147529,1.48E-15,{"v":5.19e-14,"d":"5.19E-14"},"ENSG00000148396","J3KNL6,Protein transport protein sec16","NP_055681.1,protein transport protein Sec16A isoform 1;XP_011517554.1,-","PF12932,Vesicle coat trafficking protein Sec16 mid-region;PF12931,Sec23-binding domain of Sec16","IPR024880,COPII coat assembly protein, Sec16;IPR024298,Ancestral coatomer element 1, Sec16/Sec31;IPR024340,Sec16, central conserved domain","KOG1913,Regucalcin gene promoter region-related protein (RGPR);ENOG4111J6D,-","GO:0005794,cellular_component,Golgi apparatus;GO:0048208,biological_process,COPII vesicle coating;GO:0015031,biological_process,protein transport;GO:0005783,cellular_component,endoplasmic reticulum;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport","-"]
["FOXK2",34.62910937,7.379068676,2.229944749,7.720888563,1.07E-21,1.16E-19,"ENSG00000141568","H2QE55,Forkhead box K2","-","PF00250,orkhead domain;PF00498,HA domain","IPR018122,Fork head domain conserved site1;IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily","KOG2294,Transcription factor of the Forkhead/HNF3 family;COG5025,Transcription factor of the Forkhead/HNF3 family","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0030154,biological_process,cell differentiation;GO:0009653,biological_process,anatomical structure morphogenesis;GO:0005634,cellular_component,nucleus","-"]
["ERBB3",12.25972337,2.611316437,2.22935025,6.032480511,{"v":1.72e-16,"d":"1.72E-16"},{"v":7.15e-15,"d":"7.15E-15"},"ENSG00000065361","A0A024RB84,V-erb-b2 erythroblastic leukemia viral oncogene homolog 3","-","PF14843,rowth factor receptor domain IV;PF00757,urin-like cysteine rich region;PF01030,Receptor L domain;PF07714,Protein tyrosine kinase","IPR032778,Growth factor receptor domain 4;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR006212,Furin-like repeat;IPR000494,Receptor L-domain;IPR016245,Tyrosine protein kinase, EGF/ERB/XmrK receptor;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR006211,Furin-like cysteine-rich domain;IPR036941,Receptor L-domain superfamily;IPR000719,Protein kinase domain","ENOG410XNSR,-;KOG1025,Epidermal growth factor receptor EGFR and related tyrosine kinases","GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0035556,biological_process,intracellular signal transduction;GO:0004716,molecular_function,signal transducer, downstream of receptor, with protein tyrosine kinase activity;GO:0016020,cellular_component,membrane;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0004714,molecular_function,transmembrane receptor protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0005622,cellular_component,intracellular;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane;GO:0023014,biological_process,signal transduction by protein phosphorylation","-"]
["ETV6",10.43817741,2.223017013,2.228797309,5.518807743,{"v":1.97e-14,"d":"1.97E-14"},{"v":5.19e-13,"d":"5.19E-13"},"ENSG00000139083","A0A0D9R8G7,ETS variant 6","XP_007965873.1,-","PF02198,Sterile alpha motif (SAM)/Pointed domain;PF00178,ts-domain","IPR003118,Pointed domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR000418,Ets domain;IPR036388,Winged helix-like DNA-binding domain superfamily","-","GO:0019904,molecular_function,protein domain specific binding;GO:0003677,molecular_function,DNA binding;GO:0007296,biological_process,vitellogenesis;GO:0005730,cellular_component,nucleolus;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0030154,biological_process,cell differentiation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0071425,biological_process,hematopoietic stem cell proliferation;GO:0097152,biological_process,mesenchymal cell apoptotic process;GO:0022008,biological_process,neurogenesis;GO:0005829,cellular_component,cytosol;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","K03211,ko04013,MAPK signaling pathway - fly;K03211,ko05202,Transcriptional misregulation in cancer;K03211,ko04320,Dorso-ventral axis formation"]
["CDCP1",14.41474679,3.071687437,2.228489171,5.857136224,1.03E-15,{"v":3.71e-14,"d":"3.71E-14"},"ENSG00000163814","A0A024R2T5,CUB domain containing protein 1, isoform CRA_a","-","-","IPR035914,Spermadhesin, CUB domain superfamily","ENOG410IJR2,-;ENOG4110CXF,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TCTN1",2.571145769,0.54582146,2.228478723,3.993362087,{"v":2.46e-08,"d":"2.46E-08"},{"v":1.66E-7,"d":"1.66E-07"},"ENSG00000204852","G3QN48,Tectonic family member 1","XP_018894187.1,tectonic-1 isoform X1","PF07773,Protein of unknown function (DUF1619)","IPR011677,Domain of unknown function DUF1619","-","-","-"]
["P3H4",6.603169815,1.401768749,2.228478723,3.993362087,{"v":2.46e-08,"d":"2.46E-08"},{"v":1.66E-7,"d":"1.66E-07"},"ENSG00000141696","G3R3N7,Prolyl 3-hydroxylase family member 4","-","-","IPR033213,Endoplasmic reticulum protein SC65","-","GO:0046849,biological_process,bone remodeling;GO:0030199,biological_process,collagen fibril organization;GO:0005783,cellular_component,endoplasmic reticulum;GO:0017185,biological_process,peptidyl-lysine hydroxylation;GO:0032964,biological_process,collagen biosynthetic process;GO:1902494,cellular_component,catalytic complex","-"]
["DSC3",3.499979466,0.743001009,2.228478723,3.993362087,{"v":2.46e-08,"d":"2.46E-08"},{"v":1.66E-7,"d":"1.66E-07"},"ENSG00000134762","A0A024RC29,Desmocollin 3, isoform CRA_b","-","PF08758,Cadherin prodomain like;PF00028,Cadherin domain;PF01049,Cadherin cytoplasmic region","IPR002126,Cadherin;IPR014868,Cadherin prodomain;IPR027397,Catenin binding domain superfamily;IPR000233,Cadherin, cytoplasmic domain;IPR009122,Desmosomal cadherin;IPR015919,Cadherin-like;IPR020894,Cadherin conserved site","ENOG410XQHI,-;KOG3594,FOG: Cadherin repeats","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ARL5B",4.487851551,0.956216279,2.224954149,4.362855073,{"v":1.71e-09,"d":"1.71E-09"},{"v":1.49e-08,"d":"1.49E-08"},"ENSG00000165997","Q6NXZ5,ADP-ribosylation factor-like 5B","NP_083742.2,ADP-ribosylation factor-like protein 5B","PF00025,ADP-ribosylation factor family","IPR006689,Small GTPase superfamily, ARF/SAR type;IPR005225,Small GTP-binding protein domain;IPR024156,Small GTPase superfamily, ARF type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1100,GTPase SAR1 and related small G proteins;KOG0070,GTP-binding ADP-ribosylation factor Arf1","GO:0005525,molecular_function,GTP binding;GO:1903292,biological_process,protein localization to Golgi membrane;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular","-"]
["GAREM1",4.267254196,0.909214105,2.224954149,4.362855073,{"v":1.71e-09,"d":"1.71E-09"},{"v":1.49e-08,"d":"1.49E-08"},"ENSG00000141441","K7DAY9,Family with sequence similarity 59, member A","XP_016788986.1,GRB2-associated and regulator of MAPK protein 1 isoform X2","PF12736,Cell-cycle sustaining, positive selection,","IPR025946,CABIT domain;IPR013761,Sterile alpha motif/pointed domain superfamily","ENOG410II0U,-;ENOG410XSPW,-","GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0070064,molecular_function,proline-rich region binding;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway","-"]
["UPK2",13.95561432,2.962598961,2.224047899,3.357736407,{"v":3.69e-06,"d":"3.69E-06"},{"v":1.55e-05,"d":"1.55E-05"},"ENSG00000110375","G3R130,Uroplakin 2","XP_004045429.1,uroplakin-2;XP_018885887.1,-","PF07353,Uroplakin II","IPR009952,Uroplakin-2","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["YARS2",7.172355689,1.522599652,2.224047899,3.357736407,{"v":3.69e-06,"d":"3.69E-06"},{"v":1.55e-05,"d":"1.55E-05"},"ENSG00000139131","H2Q5P6,Tyrosine--tRNA ligase","XP_528727.1,tyrosine--tRNA ligase, mitochondrial","PF00579,tRNA synthetases class I (W and Y)","IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR002307,Tyrosine-tRNA ligase;IPR036986,RNA-binding S4 domain superfamily;IPR002305,Aminoacyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I, conserved site;IPR024088,Tyrosine-tRNA ligase, bacterial-type","COG0162,Tyrosyl-tRNA synthetase;KOG2623,Tyrosyl-tRNA synthetase","GO:0070184,biological_process,mitochondrial tyrosyl-tRNA aminoacylation;GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0006437,biological_process,tyrosyl-tRNA aminoacylation;GO:0072545,molecular_function,tyrosine binding;GO:0005737,cellular_component,cytoplasm;GO:0016604,cellular_component,nuclear body;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0042803,molecular_function,protein homodimerization activity;GO:0004831,molecular_function,tyrosine-tRNA ligase activity;GO:0006412,biological_process,translation;GO:0003723,molecular_function,RNA binding;GO:0043039,biological_process,tRNA aminoacylation;GO:0005739,cellular_component,mitochondrion;GO:0000049,molecular_function,tRNA binding;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016874,molecular_function,ligase activity","K01866,ko00970,Aminoacyl-tRNA biosynthesis"]
["KRT6A",5.271485466,1.119069143,2.224047899,3.357736407,{"v":3.69e-06,"d":"3.69E-06"},{"v":1.55e-05,"d":"1.55E-05"},"ENSG00000205420","A0A0S2Z428,HCG2039812, isoform CRA_b","NP_005545.1,keratin, type II cytoskeletal 6C","PF00038,Intermediate filament protein;PF16208,Keratin type II head","IPR018039,Intermediate filament protein, conserved site;IPR001664,Intermediate filament protein;IPR032444,Keratin type II head;IPR003054,Keratin, type II","-","GO:0045095,cellular_component,keratin filament;GO:0005882,cellular_component,intermediate filament;GO:0005198,molecular_function,structural molecule activity","-"]
["RP5-1014D13.2",9.466118276,2.025113999,2.223777601,6.815809107,4.25E-19,{"v":2.92e-17,"d":"2.92E-17"},"ENSG00000279738","F7G5H6,Eukaryotic translation initiation factor 3 subunit L","-","PF10255,RNA polymerase I-associated factor PAF67","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019382,Translation initiation factor 3 complex subunit L","KOG3677,RNA polymerase I-associated factor - PAF67;ENOG410XPJT,-","GO:0003743,molecular_function,translation initiation factor activity;GO:0033290,cellular_component,eukaryotic 48S preinitiation complex;GO:0001732,biological_process,formation of cytoplasmic translation initiation complex;GO:0006413,biological_process,translational initiation;GO:0005737,cellular_component,cytoplasm;GO:0005852,cellular_component,eukaryotic translation initiation factor 3 complex;GO:0016282,cellular_component,eukaryotic 43S preinitiation complex;GO:0002183,biological_process,cytoplasmic translational initiation;GO:0006412,biological_process,translation","-"]
["PLAG1",7.245368916,1.547752773,2.223668629,5.14886669,{"v":8.99e-13,"d":"8.99E-13"},{"v":1.65e-11,"d":"1.65E-11"},"ENSG00000181690","G3SBP9,PLAG1 zinc finger","XP_018887415.1,-;XP_018887414.1,-","PF00096,Zinc finger, C2H2 type;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR027765,Zinc finger protein PLAG1","-","GO:0060252,biological_process,positive regulation of glial cell proliferation;GO:0010628,biological_process,positive regulation of gene expression;GO:0003676,molecular_function,nucleic acid binding;GO:0060736,biological_process,prostate gland growth;GO:0035264,biological_process,multicellular organism growth;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0010629,biological_process,negative regulation of gene expression;GO:0006351,biological_process,transcription, DNA-templated;GO:0016607,cellular_component,nuclear speck;GO:0035265,biological_process,organ growth;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0022612,biological_process,gland morphogenesis","-"]
["RP11-367J11.2",16.40131701,3.505236854,2.223640917,5.454668202,{"v":4.99e-14,"d":"4.99E-14"},{"v":1.21e-12,"d":"1.21E-12"},"ENSG00000245748","H2PCU2,Uncharacterized protein","-","-","-","-","-","-"]
["TXNDC11",12.5037262,2.671999203,2.222968056,5.070502505,{"v":2.39e-12,"d":"2.39E-12"},{"v":3.94e-11,"d":"3.94E-11"},"ENSG00000153066","H2R297,Uncharacterized protein","XP_016784927.1,thioredoxin domain-containing protein 11 isoform X7","PF00085,Thioredoxin","IPR013766,Thioredoxin domain;IPR036249,Thioredoxin-like superfamily","COG0526,Thiol-disulfide isomerase and thioredoxins;KOG0190,Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit)","GO:0006457,biological_process,protein folding;GO:0045454,biological_process,cell redox homeostasis;GO:0003756,molecular_function,protein disulfide isomerase activity;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0005783,cellular_component,endoplasmic reticulum","-"]
["CREBZF",4.675248967,0.997007082,2.222379995,4.071146696,{"v":2.53e-08,"d":"2.53E-08"},{"v":1.7e-07,"d":"1.70E-07"},"ENSG00000137504","E9PIM0,CREB/ATF bZIP transcription factor","XP_016873576.1,-;XP_006718705.1,CREB/ATF bZIP transcription factor isoform X1;XP_016873575.1,-","PF00170,bZIP transcription factor","IPR004827,Basic-leucine zipper domain","ENOG4111T3W,-;ENOG410IF1I,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity","-"]
["GLI3",2.827212467,0.602909251,2.222379995,4.071146696,{"v":2.53e-08,"d":"2.53E-08"},{"v":1.7e-07,"d":"1.70E-07"},"ENSG00000106571","A0A024RA92,GLI-Kruppel family member GLI3","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR032851,Transcription factor GLI3;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003676,molecular_function,nucleic acid binding;GO:0007224,biological_process,smoothened signaling pathway;GO:0048568,biological_process,embryonic organ development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0009953,biological_process,dorsal/ventral pattern formation;GO:0009952,biological_process,anterior/posterior pattern specification","-"]
["BRD4",60.79356734,13.03283859,2.221519838,8.805796822,{"v":2.25e-23,"d":"2.25E-23"},{"v":3.05e-21,"d":"3.05E-21"},"ENSG00000141867","G3R4G1,Bromodomain containing 4","-","PF17035,Bromodomain extra-terminal - transcription regulation;PF17105,C-terminal domain of bromodomain protein 4;PF00439,Bromodomain","IPR038336,NET domain superfamily;IPR031354,Bromodomain protein 4, C-terminal;IPR036427,Bromodomain-like superfamily;IPR027353,NET domain;IPR001487,Bromodomain;IPR018359,Bromodomain, conserved site","-","GO:0000794,cellular_component,condensed nuclear chromosome;GO:0050727,biological_process,regulation of inflammatory response;GO:0070577,molecular_function,lysine-acetylated histone binding;GO:0000993,molecular_function,RNA polymerase II core binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus;GO:0000083,biological_process,regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:1901407,biological_process,regulation of phosphorylation of RNA polymerase II C-terminal domain;GO:0010971,biological_process,positive regulation of G2/M transition of mitotic cell cycle;GO:0002039,molecular_function,p53 binding;GO:0005829,cellular_component,cytosol;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032968,biological_process,positive regulation of transcription elongation from RNA polymerase II promoter;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","-"]
["KIAA0895L",2.583248442,0.548390703,2.22110565,3.061548659,{"v":2.24e-05,"d":"2.24E-05"},{"v":7.88e-05,"d":"7.88E-05"},"ENSG00000196123","K7DRX2,KIAA0895-like","XP_016785504.1,-;XP_016785503.1,uncharacterized protein KIAA0895-like homolog isoform X1","PF08014,omain of unknown function (DUF1704)","IPR012548,Protein of unknown function DUF1704","ENOG410YKC2,-;ENOG410IGSS,-","-","-"]
["ST6GALNAC2",3.985773904,0.846128974,2.22110565,3.061548659,{"v":2.24e-05,"d":"2.24E-05"},{"v":7.88e-05,"d":"7.88E-05"},"ENSG00000070731","A0A024R8M1,ST6","NP_006447.2,alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 precursor","PF00777,lycosyltransferase family 29 (sialyltransferase)","IPR012163,Sialyltransferase;IPR038578,GT29-like superfamiliy;IPR001675,Glycosyl transferase family 29","KOG2692,Sialyltransferase;ENOG410XT8P,-","GO:0005794,cellular_component,Golgi apparatus;GO:0097503,biological_process,sialylation;GO:0006486,biological_process,protein glycosylation;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane;GO:0008373,molecular_function,sialyltransferase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["CELSR3",0.888659774,0.188651138,2.22110565,3.061548659,{"v":2.24e-05,"d":"2.24E-05"},{"v":7.88e-05,"d":"7.88E-05"},"ENSG00000008300","Q5Y190,Anchor protein","-","PF16489,PCR-Autoproteolysis INducing (GAIN) domain;PF00053,Laminin EGF domain;PF00916,Sulfate permease family;PF00002,7 transmembrane receptor (Secretin family);PF00008,-like domain;PF02210,Laminin G domain;PF01825,PCR proteolysis site, GPS, motif;PF01740,STAS domain;PF00028,Cadherin domain","IPR001879,GPCR, family 2, extracellular hormone receptor domain;IPR002126,Cadherin;IPR015919,Cadherin-like;IPR036445,GPCR family 2, extracellular hormone receptor domain superfamily;IPR032471,GAIN domain, N-terminal;IPR000832,GPCR, family 2, secretin-like;IPR017981,GPCR, family 2-like;IPR018045,Sulphate anion transporter, conserved site;IPR000203,GPS motif;IPR001902,SLC26A/SulP transporter;IPR002645,STAS domain;IPR001881,EGF-like calcium-binding domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR002049,Laminin EGF domain;IPR017983,GPCR, family 2, secretin-like, conserved site;IPR036513,STAS domain superfamily;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR020894,Cadherin conserved site;IPR001791,Laminin G domain;IPR011547,SLC26A/SulP transporter domain","ENOG410XTGH,-;KOG4289,Cadherin EGF LAG seven-pass G-type receptor","GO:1902358,biological_process,sulfate transmembrane transport;GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0055085,biological_process,transmembrane transport;GO:0008271,molecular_function,secondary active sulfate transmembrane transporter activity;GO:0016020,cellular_component,membrane;GO:0008272,biological_process,sulfate transport;GO:0004871,molecular_function,signal transducer activity;GO:0005509,molecular_function,calcium ion binding;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0015116,molecular_function,sulfate transmembrane transporter activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["RGS17",1.563226681,0.33185309,2.22110565,3.061548659,{"v":2.24e-05,"d":"2.24E-05"},{"v":7.88e-05,"d":"7.88E-05"},"ENSG00000091844","A0A096NYS7,Regulator of G protein signaling 17","XP_003898072.1,-","PF00615,Regulator of G protein signaling domain","IPR036305,RGS domain superfamily;IPR016137,RGS domain","-","-","-"]
["ANKH",6.338098678,1.357096643,2.220883688,5.421492494,{"v":8.07e-14,"d":"8.07E-14"},{"v":1.87e-12,"d":"1.87E-12"},"ENSG00000154122","A0A0D9RXG3,ANKH inorganic pyrophosphate transport regulator","XP_007959435.1,-","PF07260,Progressive ankylosis protein (ANKH)","IPR009887,Progressive ankylosis","-","GO:0030505,biological_process,inorganic diphosphate transport;GO:0030504,molecular_function,inorganic diphosphate transmembrane transporter activity;GO:0015114,molecular_function,phosphate ion transmembrane transporter activity;GO:0030500,biological_process,regulation of bone mineralization;GO:0035435,biological_process,phosphate ion transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0005315,molecular_function,inorganic phosphate transmembrane transporter activity;GO:0016020,cellular_component,membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["BBS2",5.326262105,1.139767291,2.220285503,4.805937873,{"v":1.81e-11,"d":"1.81E-11"},{"v":2.47e-10,"d":"2.47E-10"},"ENSG00000125124","A8K0N9,Bardet-Biedl syndrome 2 protein homolog","-","PF14782,Ciliary BBSome complex subunit 2, C-terminal;PF14781,Ciliary BBSome complex subunit 2, N-terminal;PF14783,Ciliary BBSome complex subunit 2, middle region","IPR029430,Ciliary BBSome complex subunit 2, N-terminal;IPR036322,WD40-repeat-containing domain superfamily;IPR029333,Ciliary BBSome complex subunit 2, C-terminal domain;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR016616,Bardet-Biedl syndrome 2 protein;IPR029429,Ciliary BBSome complex subunit 2, middle region","ENOG410IF6W,-;ENOG410XPDF,-","GO:0060170,cellular_component,ciliary membrane;GO:0034464,cellular_component,BBSome;GO:0005737,cellular_component,cytoplasm;GO:0042995,cellular_component,cell projection;GO:0005929,cellular_component,cilium;GO:0005856,cellular_component,cytoskeleton;GO:0005815,cellular_component,microtubule organizing center;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:1905515,biological_process,non-motile cilium assembly","-"]
["CRKL",36.38825888,7.814696249,2.218274743,6.89229884,{"v":2.65e-19,"d":"2.65E-19"},{"v":1.94e-17,"d":"1.94E-17"},"ENSG00000099942","G7PHA6,Uncharacterized protein","XP_005567948.1,-","PF07653,Variant SH3 domain;PF00018,SH3 domain;PF00017,SH2 domain","IPR035457,CRK, N-terminal SH3 domain;IPR036860,SH2 domain superfamily;IPR000980,SH2 domain;IPR035458,CRK, C-terminal SH3 domain;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain","-","GO:0048538,biological_process,thymus development;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:0007507,biological_process,heart development;GO:1900026,biological_process,positive regulation of substrate adhesion-dependent cell spreading;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0001568,biological_process,blood vessel development;GO:0009887,biological_process,animal organ morphogenesis;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol;GO:0007389,biological_process,pattern specification process;GO:0042802,molecular_function,identical protein binding;GO:0060017,biological_process,parathyroid gland development;GO:0005654,cellular_component,nucleoplasm","K04438,ko04910,Insulin signaling pathway;K04438,ko05206,MicroRNAs in cancer;K04438,ko05200,Pathways in cancer;K04438,ko05100,Bacterial invasion of epithelial cells;K04438,ko04062,Chemokine signaling pathway;K04438,ko05220,Chronic myeloid leukemia;K04438,ko05131,Shigellosis;K04438,ko04510,Focal adhesion;K04438,ko04015,Rap1 signaling pathway;K04438,ko04722,Neurotrophin signaling pathway;K04438,ko04666,Fc gamma R-mediated phagocytosis;K04438,ko04012,ErbB signaling pathway;K04438,ko04810,Regulation of actin cytoskeleton;K04438,ko04010,MAPK signaling pathway;K04438,ko05211,Renal cell carcinoma"]
["YTHDF1",23.5949493,5.062355559,2.218266199,5.595754148,{"v":1.61e-14,"d":"1.61E-14"},4.39E-13,"ENSG00000149658","B3KTL8,cDNA FLJ38476 fis, clone FEBRA2022504, highly similar to YTH domain protein 1","-","PF04146,YT521-B-like domain","IPR007275,YTH domain","ENOG410YABQ,-;KOG1901,Uncharacterized high-glucose-regulated protein","GO:0003723,molecular_function,RNA binding","-"]
["RP11-216B9.9",34.68982992,7.408043106,2.218224766,3.704044868,{"v":4.42e-07,"d":"4.42E-07"},{"v":2.25e-06,"d":"2.25E-06"},"ENSG00000280758","V9HW19,Epididymis luminal protein 209","-","-","-","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ARNTL2",5.474879477,1.173075487,2.217780279,4.597868198,{"v":1.39e-10,"d":"1.39E-10"},{"v":1.53e-09,"d":"1.53E-09"},"ENSG00000029153","H2Q5N1,Uncharacterized protein","-","PF14598,PAS domain;PF00010,Helix-loop-helix DNA-binding domain;PF00989,PAS fold","IPR000014,PAS domain;IPR001067,Nuclear translocator;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR035965,PAS domain superfamily;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR013767,PAS fold","ENOG410XRJI,-;KOG3561,Aryl-hydrocarbon receptor nuclear translocator","GO:0046983,molecular_function,protein dimerization activity;GO:0005667,cellular_component,transcription factor complex;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["AGFG1",4.101607487,0.878831255,2.217780279,4.597868198,{"v":1.39e-10,"d":"1.39E-10"},{"v":1.53e-09,"d":"1.53E-09"},"ENSG00000173744","H2R625,Uncharacterized protein","-","PF01412,Putative GTPase activating protein for Arf","-","-","-","-"]
["CTD-2231E14.8",29.50867097,6.341334817,2.216716223,6.159349808,{"v":1.05e-16,"d":"1.05E-16"},{"v":4.55e-15,"d":"4.55E-15"},"ENSG00000269243","Q59EP4,Mel transforming oncogene variant","-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0078,GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins;ENOG410XPUI,-","GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding","-"]
["SIPA1L1",6.38992012,1.37274405,2.216449693,5.621684408,{"v":1.22e-14,"d":"1.22E-14"},{"v":3.42e-13,"d":"3.42E-13"},"ENSG00000197555","K7BJF4,Signal-induced proliferation-associated 1 like 1","-","PF02145,Rap/ran-GAP;PF11881,C-terminal domain of SPAR protein","IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR035974,Rap/Ran-GAP superfamily;IPR000331,Rap GTPase activating protein domain;IPR021818,Signal-induced proliferation-associated 1-like protein, C-terminal;IPR030770,Signal-induced proliferation-associated 1-like protein 1","ENOG410XTIX,-;KOG3686,Rap1-GTPase-activating protein (Rap1GAP)","GO:0048814,biological_process,regulation of dendrite morphogenesis;GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0043087,biological_process,regulation of GTPase activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity","-"]
["IL20RB",3.744822348,0.794978031,2.216222427,2.686248037,2.73436E-4,0.000751179,"ENSG00000174564","H2QNF7,Uncharacterized protein","-","PF01108,Tissue factor;PF09294,Interferon-alpha/beta receptor, fibronectin type III","IPR003961,Fibronectin type III;IPR015373,Interferon/interleukin receptor domain;IPR013783,Immunoglobulin-like fold;IPR036116,Fibronectin type III superfamily","ENOG410YRNK,-;ENOG410IN8F,-","GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0048873,biological_process,homeostasis of number of cells within a tissue;GO:0050863,biological_process,regulation of T cell activation;GO:0032733,biological_process,positive regulation of interleukin-10 production;GO:0004920,molecular_function,interleukin-10 receptor activity;GO:0002437,biological_process,inflammatory response to antigenic stimulus;GO:0032703,biological_process,negative regulation of interleukin-2 production;GO:0002765,biological_process,immune response-inhibiting signal transduction;GO:0032753,biological_process,positive regulation of interleukin-4 production;GO:0001808,biological_process,negative regulation of type IV hypersensitivity;GO:0005886,cellular_component,plasma membrane;GO:0042130,biological_process,negative regulation of T cell proliferation;GO:0016020,cellular_component,membrane;GO:0032689,biological_process,negative regulation of interferon-gamma production;GO:0042015,molecular_function,interleukin-20 binding;GO:0016021,cellular_component,integral component of membrane","-"]
["SLC35A1",4.644406051,0.98594818,2.216222427,2.686248037,2.73436E-4,0.000751179,"ENSG00000164414","G3QT26,Solute carrier family 35 member A1","XP_004044431.1,-","PF04142,Nucleotide-sugar transporter","IPR007271,Nucleotide-sugar transporter","-","GO:0000139,cellular_component,Golgi membrane;GO:0015165,molecular_function,pyrimidine nucleotide-sugar transmembrane transporter activity;GO:0090481,biological_process,pyrimidine nucleotide-sugar transmembrane transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["USP10",27.5627554,5.930560092,2.215187887,6.429845725,{"v":1.14e-17,"d":"1.14E-17"},{"v":6.05e-16,"d":"6.05E-16"},"ENSG00000103194","A0A1D5RJ02,Uncharacterized protein","-","-","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR009818,Ataxin-2, C-terminal;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","-","GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016579,biological_process,protein deubiquitination","-"]
["MAP4K2",2.204166599,0.471211648,2.215016449,3.477517476,{"v":1.51e-06,"d":"1.51E-06"},{"v":6.9E-6,"d":"6.90E-06"},"ENSG00000168067","A0A024R567,Mitogen-activated protein kinase kinase kinase kinase","NP_004570.2,mitogen-activated protein kinase kinase kinase kinase 2 isoform 1","PF00069,Protein kinase domain;PF00780,CNH domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR021160,Mitogen-activated protein (MAP) kinase kinase kinase kinase;IPR001180,Citron homology (CNH) domain;IPR000719,Protein kinase domain","ENOG410XP9G,-;KOG0576,Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family","GO:0016301,molecular_function,kinase activity;GO:0000165,biological_process,MAPK cascade;GO:0008349,molecular_function,MAP kinase kinase kinase kinase activity;GO:0005623,cellular_component,cell;GO:0016310,biological_process,phosphorylation;GO:0000185,biological_process,activation of MAPKKK activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0016740,molecular_function,transferase activity;GO:0005622,cellular_component,intracellular;GO:0006903,biological_process,vesicle targeting;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","K04414,ko04010,MAPK signaling pathway"]
["TAF6",27.95358049,6.014380416,2.214960476,6.139106604,{"v":9.45e-17,"d":"9.45E-17"},4.15E-15,"ENSG00000106290","J3KR72,Transcription initiation factor TFIID subunit 6","-","PF07571,TAF6 C-terminal HEAT repeat domain;PF02969,TATA box binding protein associated factor (TAF)","IPR016024,Armadillo-type fold;IPR037796,Transcription initiation factor TFIID subunit 6;IPR004823,TATA box binding protein associated factor (TAF);IPR009072,Histone-fold;IPR011442,TAF6, C-terminal HEAT repeat domain","COG5095,Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA);KOG2549,Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA)","GO:0051090,biological_process,regulation of DNA binding transcription factor activity;GO:0046695,cellular_component,SLIK (SAGA-like) complex;GO:0006352,biological_process,DNA-templated transcription, initiation;GO:0046982,molecular_function,protein heterodimerization activity;GO:0000124,cellular_component,SAGA complex;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005669,cellular_component,transcription factor TFIID complex;GO:0005654,cellular_component,nucleoplasm","-"]
["VEGFC",10.10677478,2.166369885,2.214559027,3.982321168,{"v":3.3e-08,"d":"3.30E-08"},{"v":2.17E-7,"d":"2.17E-07"},"ENSG00000150630","Q6FH59,VEGFC protein","-","PF03128,CXCXC repeat;PF00341,PDGF/VEGF domain","IPR004153,CXCXC repeat;IPR023581,Platelet-derived growth factor, conserved site;IPR000072,PDGF/VEGF domain;IPR029034,Cystine-knot cytokine","ENOG410IFTP,-;ENOG410YGVZ,-","GO:0008083,molecular_function,growth factor activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0016020,cellular_component,membrane","-"]
["RSU1",7.649038323,1.641835444,2.214318282,4.354359258,{"v":2.21E-9,"d":"2.21E-09"},{"v":1.88E-8,"d":"1.88E-08"},"ENSG00000148484","H9EP80,Ras suppressor protein 1 isoform 1","XP_001093095.3,-","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR003591,Leucine-rich repeat, typical subtype;IPR025875,Leucine rich repeat 4;IPR032675,Leucine-rich repeat domain superfamily","COG4886,Leucine-rich repeat (LRR) protein;KOG0617,Ras suppressor protein (contains leucine-rich repeats)","-","-"]
["SIGMAR1",110.8363611,23.87347505,2.214207881,7.219350823,{"v":3.55e-20,"d":"3.55E-20"},{"v":2.98e-18,"d":"2.98E-18"},"ENSG00000147955","G3QKA2,Sigma non-opioid intracellular receptor 1","XP_004048016.1,-","PF04622,RG2 and Sigma1 receptor like protein","IPR006716,ERG2/sigma1 receptor-like","-","GO:0005783,cellular_component,endoplasmic reticulum;GO:0070207,biological_process,protein homotrimerization;GO:0014069,cellular_component,postsynaptic density;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0005635,cellular_component,nuclear envelope;GO:0004872,-,-;GO:0043523,biological_process,regulation of neuron apoptotic process","-"]
["ELL2",30.29820358,6.528229119,2.213654648,7.087856214,{"v":7.51e-20,"d":"7.51E-20"},{"v":5.98e-18,"d":"5.98E-18"},"ENSG00000118985","H2QR91,Elongation factor, RNA polymerase II, 2","XP_517646.2,RNA polymerase II elongation factor ELL2 isoform X1","PF07303,Occludin homology domain;PF10390,RNA polymerase II elongation factor ELL","IPR019464,RNA polymerase II elongation factor ELL, N-terminal;IPR010844,Occludin homology domain;IPR031176,ELL/occludin family;IPR031179,RNA polymerase II elongation factor ELL2;IPR036390,Winged helix DNA-binding domain superfamily","KOG4796,RNA polymerase II elongation factor;ENOG410ZNGU,-","GO:0006368,biological_process,transcription elongation from RNA polymerase II promoter;GO:0003746,molecular_function,translation elongation factor activity;GO:0042795,biological_process,snRNA transcription by RNA polymerase II;GO:0006414,biological_process,translational elongation;GO:0008023,cellular_component,transcription elongation factor complex;GO:0005654,cellular_component,nucleoplasm","-"]
["FAM222B",16.27855185,3.506010747,2.21305677,5.797406334,{"v":2.08e-15,"d":"2.08E-15"},{"v":6.92e-14,"d":"6.92E-14"},"ENSG00000173065","H2NT52,Family with sequence similarity 222 member B","XP_009249713.1,-;XP_002827231.1,-","PF15258,Protein family of FAM222A","IPR029340,Protein FAM222","ENOG410IEMV,-;ENOG410YNEB,-","GO:0005654,cellular_component,nucleoplasm","-"]
["MGAT2",16.43750913,3.536375105,2.212555862,4.799722749,{"v":2.26e-11,"d":"2.26E-11"},{"v":3.01e-10,"d":"3.01E-10"},"ENSG00000168282","B4DDK9,cDNA FLJ55952, highly similar to Alpha-1,6-mannosyl-glycoprotein2-beta-N- acetylglucosaminyltransferase","-","PF05060,N-acetylglucosaminyltransferase II (MGAT2)","IPR029044,Nucleotide-diphospho-sugar transferases;IPR007754,N-acetylglucosaminyltransferase II","KOG2791,N-acetylglucosaminyltransferase;ENOG410XPYF,-","GO:0005795,cellular_component,Golgi stack;GO:0008455,molecular_function,alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;GO:0009312,biological_process,oligosaccharide biosynthetic process;GO:0016740,molecular_function,transferase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["CORO2A",15.16056551,3.266891091,2.212249765,5.747975319,{"v":3.92e-15,"d":"3.92E-15"},{"v":1.23e-13,"d":"1.23E-13"},"ENSG00000106789","A0A024R150,Coronin","XP_011517288.1,-;NP_003380.3,-;NP_438171.1,coronin-2A","PF16300,Type of WD40 repeat;PF00400,WD domain, G-beta repeat;PF08953,omain of unknown function (DUF1899)","IPR015505,Coronin;IPR019775,WD40 repeat, conserved site;IPR027335,Coronin 2A;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015048,Domain of unknown function DUF1899;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat","ENOG410XQAD,-;KOG0303,Actin-binding protein Coronin, contains WD40 repeats","GO:0017053,cellular_component,transcriptional repressor complex;GO:0051015,molecular_function,actin filament binding","-"]
["MAP4",11.79116829,2.543596308,2.211740961,6.757559595,{"v":8.48e-19,"d":"8.48E-19"},{"v":5.5E-17,"d":"5.50E-17"},"ENSG00000047849","E7EVA0,Microtubule-associated protein","-","PF00418,Tau and MAP protein, tubulin-binding repeat","IPR001084,Microtubule associated protein,  tubulin-binding repeat","ENOG4111J07,-;ENOG410IG6M,-","GO:0005874,cellular_component,microtubule;GO:0005737,cellular_component,cytoplasm;GO:0005856,cellular_component,cytoskeleton;GO:0005886,cellular_component,plasma membrane;GO:0015631,molecular_function,tubulin binding;GO:0005829,cellular_component,cytosol;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["MED13L",7.732218727,1.667691334,2.211680396,6.363701173,1.96E-17,{"v":9.9e-16,"d":"9.90E-16"},"ENSG00000123066","K7B153,Mediator of RNA polymerase II transcription subunit 13","XP_003313999.3,mediator of RNA polymerase II transcription subunit 13-like isoform X4","PF06333,Mediator complex subunit 13 C-terminal;PF11597,Mediator complex subunit 13 N-terminal","IPR021643,Mediator complex, subunit Med13, N-terminal, metazoa/fungi;IPR009401,Mediator complex, subunit Med13","KOG3600,Thyroid hormone receptor-associated protein complex, subunit TRAP240;ENOG410XPV2,-","GO:0016592,cellular_component,mediator complex;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component,nucleus","K15164,ko04919,Thyroid hormone signaling pathway"]
["FOXP4",6.658120767,1.433859484,2.210817531,4.699004488,{"v":7.49e-11,"d":"7.49E-11"},{"v":8.78e-10,"d":"8.78E-10"},"ENSG00000137166","K7A5L8,Forkhead box P4","XP_016810930.1,-;XP_016800505.1,forkhead box protein P4 isoform X2","PF00250,orkhead domain;PF16159,OXP coiled-coil domain","IPR032354,FOXP, coiled-coil domain;IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily","COG5025,Transcription factor of the Forkhead/HNF3 family;KOG4385,Predicted forkhead transcription factor","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["ADGRL2",10.38160811,2.23963923,2.210451776,5.643710248,{"v":9.27e-15,"d":"9.27E-15"},{"v":2.68e-13,"d":"2.68E-13"},"ENSG00000117114","G3RJN0,Adhesion G protein-coupled receptor L2","-","PF16489,PCR-Autoproteolysis INducing (GAIN) domain;PF00002,7 transmembrane receptor (Secretin family);PF02191,Olfactomedin-like domain;PF01825,PCR proteolysis site, GPS, motif;PF02793,Hormone receptor domain;PF02354,Latrophilin Cytoplasmic C-terminal region;PF02140,alactose binding lectin domain","IPR032471,GAIN domain, N-terminal;IPR003334,GPCR, family 2, latrophilin, C-terminal;IPR036445,GPCR family 2, extracellular hormone receptor domain superfamily;IPR001879,GPCR, family 2, extracellular hormone receptor domain;IPR000832,GPCR, family 2, secretin-like;IPR017981,GPCR, family 2-like;IPR031240,Latrophilin-2;IPR000203,GPS motif;IPR003112,Olfactomedin-like domain;IPR017983,GPCR, family 2, secretin-like, conserved site;IPR003924,GPCR, family 2, latrophilin;IPR000922,D-galactoside/L-rhamnose binding SUEL lectin domain","-","GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0030246,molecular_function,carbohydrate binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0007165,biological_process,signal transduction","-"]
["GPAM",1.40423006,0.300669964,2.210386104,3.207796137,{"v":1.89e-05,"d":"1.89E-05"},{"v":6.77e-05,"d":"6.77E-05"},"ENSG00000119927","Q6ZMF6,Glycerol-3-phosphate acyltransferase 1, mitochondrial","-","PF01553,Acyltransferase","IPR002123,Phospholipid/glycerol acyltransferase;IPR028354,Glycerol-3-phosphate acyltransferase, PlsB;IPR022284,Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase","COG2937,Glycerol-3-phosphate O-acyltransferase;KOG3729,Mitochondrial glycerol-3-phosphate acyltransferase GPAT","GO:0008654,biological_process,phospholipid biosynthetic process;GO:0044255,biological_process,cellular lipid metabolic process;GO:0006629,biological_process,lipid metabolic process;GO:0102420,molecular_function,sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity;GO:0016740,molecular_function,transferase activity;GO:0031966,cellular_component,mitochondrial membrane;GO:0008374,molecular_function,O-acyltransferase activity;GO:0016024,biological_process,CDP-diacylglycerol biosynthetic process;GO:0005886,cellular_component,plasma membrane;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0004366,molecular_function,glycerol-3-phosphate O-acyltransferase activity;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0005741,cellular_component,mitochondrial outer membrane","-"]
["MALL",14.39606817,3.103853285,2.209588422,4.844533372,{"v":2.62e-11,"d":"2.62E-11"},3.45E-10,"ENSG00000144063","H2QIJ1,Uncharacterized protein","XP_515683.1,MAL-like protein isoform X2","PF01284,Membrane-associating domain","IPR008253,Marvel domain;IPR013295,Myelin and lymphocyte (MAL) protein","ENOG410YQN9,-;ENOG410IWII,-","GO:0045121,cellular_component,membrane raft;GO:0019911,molecular_function,structural constituent of myelin sheath;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0001766,biological_process,membrane raft polarization;GO:0008104,biological_process,protein localization;GO:0042552,biological_process,myelination;GO:0000139,cellular_component,Golgi membrane;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0030136,cellular_component,clathrin-coated vesicle","-"]
["FAM168A",19.419525,4.196019773,2.209238979,6.557972785,{"v":3.86e-18,"d":"3.86E-18"},{"v":2.24e-16,"d":"2.24E-16"},"ENSG00000054965","H0V953,Family with sequence similarity 168 member A","XP_003463501.1,protein FAM168A isoform X1;XP_013000776.1,-","PF14944,Tongue Cancer Chemotherapy Resistant Protein 1","IPR029247,FAM168A/MANI","ENOG410XR79,-;ENOG410IHUV,-","-","-"]
["MED14",3.934716575,0.848341562,2.208799606,4.590671682,{"v":1.76e-10,"d":"1.76E-10"},{"v":1.91e-09,"d":"1.91E-09"},"ENSG00000180182","K7DMQ6,Mediator complex subunit 14","XP_016798618.1,-","PF08638,Mediator complex subunit MED14","IPR013947,Mediator complex, subunit Med14","KOG1875,Thyroid hormone receptor-associated coactivator complex component (TRAP170);ENOG410XWK4,-","GO:0019827,biological_process,stem cell population maintenance;GO:0003712,molecular_function,transcription cofactor activity;GO:0016592,cellular_component,mediator complex;GO:0030521,biological_process,androgen receptor signaling pathway;GO:0003713,molecular_function,transcription coactivator activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0030518,biological_process,intracellular steroid hormone receptor signaling pathway;GO:0006367,biological_process,transcription initiation from RNA polymerase II promoter;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component,nucleus;GO:0004872,-,-","-"]
["NDRG3",13.08662746,2.824684871,2.207696879,4.747019436,{"v":4.56e-11,"d":"4.56E-11"},{"v":5.62e-10,"d":"5.62E-10"},"ENSG00000101079","Q5TH30,NDRG family member 3, isoform CRA_c","XP_006723900.1,protein NDRG3 isoform X3;XP_016883467.1,-","PF03096,Ndr family","IPR030692,Protein NDRG3;IPR029058,Alpha/Beta hydrolase fold;IPR004142,NDRG","ENOG410XSPF,-;KOG2931,Differentiation-related gene 1 protein (NDR1 protein), related proteins","-","-"]
["CARD6",4.156497201,0.893830721,2.207433637,3.58797881,{"v":6.39e-07,"d":"6.39E-07"},{"v":3.15e-06,"d":"3.15E-06"},"ENSG00000132357","H2QQT4,Caspase recruitment domain family, member 6","XP_517788.2,caspase recruitment domain-containing protein 6","PF00619,Caspase recruitment domain","IPR001315,CARD domain;IPR011029,Death-like domain superfamily","ENOG410IEZI,-;ENOG410XXII,-","GO:0042981,biological_process,regulation of apoptotic process","K12797,ko04621,NOD-like receptor signaling pathway"]
["LZTS2",7.181473769,1.55148416,2.206806246,4.88798808,{"v":1.65e-11,"d":"1.65E-11"},{"v":2.28e-10,"d":"2.28E-10"},"ENSG00000107816","G3RHD5,Leucine zipper putative tumor suppressor 2","XP_018890132.1,-;XP_004050008.2,-;XP_004050007.2,leucine zipper putative tumor suppressor 2;XP_018890130.1,-;XP_018890131.1,-","PF06818,ez1","IPR028597,Leucine zipper putative tumour suppressor 2","-","GO:0030496,cellular_component,midbody;GO:0030178,biological_process,negative regulation of Wnt signaling pathway;GO:0005874,cellular_component,microtubule;GO:0051255,biological_process,spindle midzone assembly;GO:0005737,cellular_component,cytoplasm;GO:0016055,biological_process,Wnt signaling pathway;GO:0000910,biological_process,cytokinesis;GO:0005856,cellular_component,cytoskeleton;GO:0007049,biological_process,cell cycle;GO:0051168,biological_process,nuclear export;GO:0005815,cellular_component,microtubule organizing center;GO:0051301,biological_process,cell division;GO:0005813,cellular_component,centrosome;GO:0051013,biological_process,microtubule severing","-"]
["FUT8",7.01747892,1.516054746,2.206806246,4.88798808,{"v":1.65e-11,"d":"1.65E-11"},{"v":2.28e-10,"d":"2.28E-10"},"ENSG00000033170","K7ASB1,Alpha-","XP_009425923.1,-;XP_016781229.1,-;XP_009425924.1,-;XP_016781228.1,-;NP_001008984.1,-","PF14604,Variant SH3 domain","IPR035653,Alpha-(1,6)-fucosyltransferase, SH3 domain;IPR001452,SH3 domain;IPR027350,Glycosyltransferase family 23 (GT23) domain;IPR036028,SH3-like domain superfamily;IPR015827,Alpha-(1,6)-fucosyltransferase","KOG3705,Glycoprotein 6-alpha-L-fucosyltransferase;ENOG410YHM8,-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0036071,biological_process,N-glycan fucosylation;GO:0033578,biological_process,protein glycosylation in Golgi;GO:0046921,molecular_function,alpha-(1->6)-fucosyltransferase activity;GO:0005794,cellular_component,Golgi apparatus;GO:0032580,cellular_component,Golgi cisterna membrane;GO:0008424,molecular_function,glycoprotein 6-alpha-L-fucosyltransferase activity;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016740,molecular_function,transferase activity;GO:0006491,biological_process,N-glycan processing;GO:0018279,biological_process,protein N-linked glycosylation via asparagine;GO:0016020,cellular_component,membrane;GO:0010468,biological_process,regulation of gene expression;GO:0007585,biological_process,respiratory gaseous exchange;GO:0043112,biological_process,receptor metabolic process;GO:0005829,cellular_component,cytosol;GO:0046368,biological_process,GDP-L-fucose metabolic process;GO:0006486,biological_process,protein glycosylation;GO:1900407,biological_process,regulation of cellular response to oxidative stress;GO:0016477,biological_process,cell migration","K00717,ko05202,Transcriptional misregulation in cancer;K00717,ko00533,Glycosaminoglycan biosynthesis - keratan sulfate;K00717,ko00510,N-Glycan biosynthesis;K00717,ko00513,Various types of N-glycan biosynthesis"]
["ZNF684",2.031577419,0.43127798,2.206532137,2.172780374,0.001822828,0.00415978,"ENSG00000117010","B3KSP5,cDNA FLJ36753 fis, clone UTERU2017761, highly similar to Zinc finger protein 684","NP_689586.3,zinc finger protein 684","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["POU2F3",0.929114188,0.197239094,2.206532137,2.172780374,0.001822828,0.00415978,"ENSG00000137709","G1R754,POU domain protein","-","PF00157,Pou domain - N-terminal to homeobox domain;PF00046,Homeobox domain","IPR009057,Homeobox-like domain superfamily;IPR010982,Lambda repressor-like, DNA-binding domain superfamily;IPR017970,Homeobox, conserved site;IPR000972,Octamer-binding transcription factor;IPR001387,Cro/C1-type helix-turn-helix domain;IPR013847,POU domain;IPR001356,Homeobox domain;IPR000327,POU-specific domain","ENOG410XQ7X,-;KOG3802,Transcription factor OCT-1, contains POU and HOX domains","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0043922,biological_process,negative regulation by host of viral transcription;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["SOCS2",0.911151679,0.193425883,2.206532137,2.172780374,0.001822828,0.00415978,"ENSG00000120833","A0A024RBD2,Suppressor of cytokine signaling 2, isoform CRA_a","NP_001257397.1,-;NP_001257396.1,-;NP_001257398.1,-;NP_001257400.1,-;NP_001257399.1,-;XP_016875645.1,-;NP_003868.1,suppressor of cytokine signaling 2","PF07525,SOCS box;PF00017,SH2 domain","IPR001496,SOCS box domain;IPR036860,SH2 domain superfamily;IPR036036,SOCS box-like domain superfamily;IPR000980,SH2 domain;IPR028410,Suppressor of cytokine signalling 2;IPR035862,SOCS2, SH2 domain","KOG4566,Cytokine-inducible SH2 protein;ENOG4111V4J,-","GO:0001558,biological_process,regulation of cell growth;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0046426,biological_process,negative regulation of JAK-STAT cascade;GO:0035556,biological_process,intracellular signal transduction;GO:0007595,biological_process,lactation;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0005131,molecular_function,growth hormone receptor binding;GO:0040015,biological_process,negative regulation of multicellular organism growth;GO:0060749,biological_process,mammary gland alveolus development;GO:0040014,biological_process,regulation of multicellular organism growth;GO:0005159,molecular_function,insulin-like growth factor receptor binding;GO:0008269,molecular_function,JAK pathway signal transduction adaptor activity","K04695,ko04917,Prolactin signaling pathway;K04695,ko04910,Insulin signaling pathway;K04695,ko04930,Type II diabetes mellitus;K04695,ko04630,Jak-STAT signaling pathway"]
["STEAP2",0.708429579,0.150390566,2.206532137,2.172780374,0.001822828,0.00415978,"ENSG00000157214","K7DAA1,Six transmembrane epithelial antigen of the prostate 2","XP_016800700.1,-;XP_016800701.1,-;XP_016800704.1,-;XP_016800707.1,-;XP_016800702.1,-;XP_016800706.1,-;XP_016800703.1,-;XP_016800705.1,-","PF03807,NADP oxidoreductase coenzyme F420-dependent;PF01794,erric reductase like transmembrane component","IPR036291,NAD(P)-binding domain superfamily;IPR013130,Ferric reductase transmembrane component-like domain;IPR028939,Pyrroline-5-carboxylate reductase, catalytic, N-terminal","COG2085,Predicted dinucleotide-binding enzymes;ENOG410IF4F,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K14738,ko04978,Mineral absorption"]
["FNDC3B",41.03211101,8.889136415,2.206308488,8.376546505,{"v":1.64e-22,"d":"1.64E-22"},2.03E-20,"ENSG00000075420","H2QNR3,Fibronectin type III domain containing 3B","-","PF00041,ibronectin type III domain","IPR003961,Fibronectin type III;IPR036116,Fibronectin type III superfamily;IPR013783,Immunoglobulin-like fold","ENOG410IE8R,-;ENOG410XNUW,-","-","-"]
["ALMS1",7.316083884,1.585393074,2.20448693,5.991537062,{"v":5.13e-16,"d":"5.13E-16"},{"v":1.97e-14,"d":"1.97E-14"},"ENSG00000116127","A0A087WZY3,Alstrom syndrome protein 1","-","PF15309,ALMS motif","IPR028781,Alstrom syndrome protein 1;IPR029299,ALMS motif","-","GO:0005829,cellular_component,cytosol;GO:0051492,biological_process,regulation of stress fiber assembly;GO:0016197,biological_process,endosomal transport","-"]
["TRIM62",7.489829048,1.617647288,2.204457932,4.134999725,{"v":1.28E-8,"d":"1.28E-08"},{"v":9.2e-08,"d":"9.20E-08"},"ENSG00000116525","A0A1U7QUN1,E3 ubiquitin-protein ligase TRIM62","XP_005079533.1,E3 ubiquitin-protein ligase TRIM62","-","IPR035830,TRIM62, PRY/SPRY domain;IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR003877,SPRY domain;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000315,B-box-type zinc finger;IPR006574,SPRY-associated","-","GO:0008270,molecular_function,zinc ion binding;GO:0016874,molecular_function,ligase activity;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["DUXAP8",4.924782093,1.063650498,2.204457932,4.134999725,{"v":1.28E-8,"d":"1.28E-08"},{"v":9.2e-08,"d":"9.20E-08"},"ENSG00000271672","G3QSA4,Double homeobox A","XP_004061580.1,double homeobox protein A","PF00046,Homeobox domain","IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR000047,Helix-turn-helix motif","-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["ARHGEF34P",15.35212325,3.325798428,2.204088258,5.438833028,{"v":9.71e-14,"d":"9.71E-14"},{"v":2.22e-12,"d":"2.22E-12"},"ENSG00000204959","B9EGR7,Rho guanine nucleotide exchange factor","-","PF14604,Variant SH3 domain;PF00621,RhoGEF domain;PF15441,Rho guanine nucleotide exchange factor 5/35","IPR029212,Rho guanine nucleotide exchange factor 5/35, N-terminal;IPR001331,Guanine-nucleotide dissociation stimulator, CDC24, conserved site;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR035899,Dbl homology (DH) domain superfamily;IPR001452,SH3 domain;IPR000219,Dbl homology (DH) domain","COG5422,RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases;KOG3523,Putative guanine nucleotide exchange factor TIM","GO:0035556,biological_process,intracellular signal transduction;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005622,cellular_component,intracellular;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","-"]
["PTPN12",33.21959126,7.206587399,2.203673935,6.822986057,{"v":6.61e-19,"d":"6.61E-19"},{"v":4.33e-17,"d":"4.33E-17"},"ENSG00000127947","G3SHJ7,Tyrosine-protein phosphatase","XP_004045685.1,tyrosine-protein phosphatase non-receptor type 12","PF00102,Protein-tyrosine phosphatase","IPR016130,Protein-tyrosine phosphatase, active site;IPR000242,PTP type protein phosphatase;IPR029021,Protein-tyrosine phosphatase-like;IPR012266,Protein-tyrosine phosphatase, non-receptor type-12;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR000387,Tyrosine specific protein phosphatases domain","-","GO:0002102,cellular_component,podosome;GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0042058,biological_process,regulation of epidermal growth factor receptor signaling pathway;GO:0006470,biological_process,protein dephosphorylation;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0017124,molecular_function,SH3 domain binding;GO:0005829,cellular_component,cytosol;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","-"]
["SNX33",3.97348395,0.859257286,2.203603423,4.345811765,{"v":2.85e-09,"d":"2.85E-09"},{"v":2.36E-8,"d":"2.36E-08"},"ENSG00000173548","H2Q9U6,Sorting nexin","XP_016782710.1,-","PF14604,Variant SH3 domain;PF00787,PX domain;PF10456,WASP-binding domain of Sorting nexin protein","IPR014536,Sorting nexin 9 family;IPR037427,Sorting nexin-33, BAR domain;IPR036871,PX domain superfamily;IPR027267,AH/BAR domain superfamily;IPR001683,Phox homologous domain;IPR001452,SH3 domain;IPR036028,SH3-like domain superfamily;IPR028642,Sorting nexin-33;IPR019497,Sorting nexin protein, WASP-binding domain","KOG2528,Sorting nexin SNX9/SH3PX1 and related proteins;ENOG410XPHZ,-","GO:0097320,biological_process,plasma membrane tubulation;GO:0036089,biological_process,cleavage furrow formation;GO:0030659,cellular_component,cytoplasmic vesicle membrane;GO:0019898,cellular_component,extrinsic component of membrane;GO:2000009,biological_process,negative regulation of protein localization to cell surface;GO:0044351,biological_process,macropinocytosis;GO:0007032,biological_process,endosome organization;GO:0000278,biological_process,mitotic cell cycle;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0045806,biological_process,negative regulation of endocytosis;GO:2000010,biological_process,positive regulation of protein localization to cell surface;GO:0051044,biological_process,positive regulation of membrane protein ectodomain proteolysis;GO:0016197,biological_process,endosomal transport;GO:0016020,cellular_component,membrane;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0015031,biological_process,protein transport;GO:0000281,biological_process,mitotic cytokinesis;GO:0017038,biological_process,protein import;GO:0006897,biological_process,endocytosis;GO:0006886,biological_process,intracellular protein transport","-"]
["TRPS1",23.18410559,5.030959688,2.203532767,7.297424747,{"v":3.27e-20,"d":"3.27E-20"},2.76E-18,"ENSG00000104447","H2QWL5,Trichorhinophalangeal syndrome I","-","PF00320,ATA zinc finger","IPR013087,Zinc finger C2H2-type;IPR028440,Transcription factor TRPS1","COG5641,GATA Zn-finger-containing transcription factor;KOG1601,GATA-4/5/6 transcription factors","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0003676,molecular_function,nucleic acid binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030154,biological_process,cell differentiation;GO:0046872,molecular_function,metal ion binding;GO:0001085,molecular_function,RNA polymerase II transcription factor binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["PANK4",2.092364703,0.449117704,2.203119069,2.874191252,{"v":9.19e-05,"d":"9.19E-05"},0.000279433,"ENSG00000157881","B4DHW9,Pantothenate kinase 4","-","PF01937,Protein of unknown function DUF89;PF03630,umble","IPR002791,Domain of unknown function DUF89;IPR004567,Type II pantothenate kinase;IPR015844,Pantothenate kinase, acetyl-CoA regulated, two-domain type;IPR036075,AF1104-like superfamily;IPR035073,At2g17340, three-helix bundle domain","KOG4584,Uncharacterized conserved protein;KOG2201,Pantothenate kinase PanK and related proteins;COG5146,Pantothenate kinase, acetyl-CoA regulated","GO:0016301,molecular_function,kinase activity;GO:0004594,molecular_function,pantothenate kinase activity;GO:0005737,cellular_component,cytoplasm;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0015937,biological_process,coenzyme A biosynthetic process","-"]
["ANKS3",1.358122336,0.291515521,2.203119069,2.874191252,{"v":9.19e-05,"d":"9.19E-05"},0.000279433,"ENSG00000168096","G3R5T2,Ankyrin repeat and sterile alpha motif domain containing 3","XP_018867685.1,-;XP_004057179.1,ankyrin repeat and SAM domain-containing protein 3 isoform X2","PF12796,Ankyrin repeats (3 copies);PF00536,SAM domain (Sterile alpha motif)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","-","-","-"]
["ZNF821",3.141007213,0.67420462,2.203119069,2.874191252,{"v":9.19e-05,"d":"9.19E-05"},0.000279433,"ENSG00000102984","H2R1Y5,Zinc finger protein 821","XP_016785626.1,-;XP_003315244.1,-;XP_003315245.1,-","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","ENOG410Z0QD,-;ENOG410ITHI,-","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II","-"]
["RP11-542C16.1",25.38172574,5.448085785,2.203119069,2.874191252,{"v":9.19e-05,"d":"9.19E-05"},0.000279433,"-","-","-","-","-","-","-","-"]
["SENP1",9.772484692,2.118290957,2.202934002,5.276102993,{"v":4.33e-13,"d":"4.33E-13"},{"v":8.57e-12,"d":"8.57E-12"},"ENSG00000079387","K7D7C5,SUMO1/sentrin specific peptidase 1","XP_016779031.1,-;XP_016779030.1,sentrin-specific protease 1 isoform X4","PF02902,Ulp1 protease family, C-terminal catalytic domain","IPR003653,Ulp1 protease family, C-terminal catalytic domain","COG5160,Protease, Ulp1 family;KOG0778,Protease, Ulp1 family","GO:0006508,biological_process,proteolysis;GO:0070140,molecular_function,SUMO-specific isopeptidase activity;GO:0032435,biological_process,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0016926,biological_process,protein desumoylation;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0010724,biological_process,regulation of definitive erythrocyte differentiation;GO:0031965,cellular_component,nuclear membrane;GO:0006919,biological_process,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0097190,biological_process,apoptotic signaling pathway;GO:0005925,cellular_component,focal adhesion;GO:0005634,cellular_component,nucleus","-"]
["ZNF45",4.486499444,0.96963915,2.200976717,3.69047472,{"v":6.04e-07,"d":"6.04E-07"},{"v":2.99e-06,"d":"2.99E-06"},"ENSG00000124459","A0A024R0Q1,Zinc finger protein 45, isoform CRA_a","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["EPC1",2.14610445,0.464523757,2.200503719,3.971192336,{"v":4.43E-8,"d":"4.43E-08"},{"v":2.81e-07,"d":"2.81E-07"},"ENSG00000120616","K7AQ28,Enhancer of polycomb homolog","XP_016818429.1,-","PF06752,nhancer of Polycomb C-terminus;PF10513,nhancer of polycomb-like","IPR019542,Enhancer of polycomb-like, N-terminal;IPR009607,Enhancer of polycomb, C-terminal;IPR024943,Enhancer of polycomb protein","KOG2261,Polycomb enhancer protein, EPC;ENOG410XSSX,-","GO:0043967,biological_process,histone H4 acetylation;GO:0004402,molecular_function,histone acetyltransferase activity;GO:0043968,biological_process,histone H2A acetylation;GO:0045814,biological_process,negative regulation of gene expression, epigenetic;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0035267,cellular_component,NuA4 histone acetyltransferase complex;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0031965,cellular_component,nuclear membrane;GO:0006351,biological_process,transcription, DNA-templated;GO:0032777,cellular_component,Piccolo NuA4 histone acetyltransferase complex;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["ITGA5",3.196639147,0.691911722,2.200503719,3.971192336,{"v":4.43E-8,"d":"4.43E-08"},{"v":2.81e-07,"d":"2.81E-07"},"ENSG00000161638","A0A024RB01,Integrin, alpha 5","-","PF01839,-GAP repeat;PF08441,Integrin alpha","IPR013517,FG-GAP repeat;IPR018184,Integrin alpha chain, C-terminal cytoplasmic region, conserved site;IPR032695,Integrin domain superfamily;IPR013649,Integrin alpha-2;IPR013519,Integrin alpha beta-propellor;IPR000413,Integrin alpha chain;IPR028994,Integrin alpha, N-terminal","ENOG410XPVZ,-;KOG3637,Vitronectin receptor, alpha subunit","GO:0008305,cellular_component,integrin complex;GO:0007155,biological_process,cell adhesion;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["AKIRIN2",14.37352555,3.114359908,2.200179177,4.20562812,{"v":6.59e-09,"d":"6.59E-09"},{"v":5.06e-08,"d":"5.06E-08"},"ENSG00000135334","F7H077,Akirin-2","XP_014992404.1,-","-","IPR024132,Akirin","ENOG4111J00,-;KOG4330,Uncharacterized conserved protein","-","-"]
["UBQLN4",26.81989263,5.830009724,2.200015898,6.008608304,{"v":4.73e-16,"d":"4.73E-16"},{"v":1.82e-14,"d":"1.82E-14"},"ENSG00000160803","U3FE53,Ubiquilin-4","XP_008982837.1,ubiquilin-4","PF00627,UBA/TS-N domain;PF00240,Ubiquitin family","IPR006636,Heat shock chaperonin-binding;IPR015496,Ubiquilin;IPR009060,UBA-like superfamily;IPR015940,Ubiquitin-associated domain;IPR000626,Ubiquitin domain;IPR029071,Ubiquitin-like domain superfamily","COG5272,Ubiquitin;KOG0010,Ubiquitin-like protein","-","K04523,ko04141,Protein processing in endoplasmic reticulum"]
["NUFIP2",25.9345873,5.647287026,2.1986138,7.429947744,1.84E-20,{"v":1.65e-18,"d":"1.65E-18"},"ENSG00000108256","G3QZT0,NUFIP2, FMR1 interacting protein 2","XP_004042082.1,-","PF15293,Nuclear fragile X mental retardation-interacting protein 2","IPR032747,Nuclear fragile X mental retardation-interacting protein 2","-","GO:0010494,cellular_component,cytoplasmic stress granule;GO:0005737,cellular_component,cytoplasm;GO:0016604,cellular_component,nuclear body;GO:0003723,molecular_function,RNA binding;GO:0005829,cellular_component,cytosol;GO:0042788,cellular_component,polysomal ribosome;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["PHLDA1",66.15570784,14.41572971,2.197887949,8.349538962,{"v":2.52e-22,"d":"2.52E-22"},{"v":3.04e-20,"d":"3.04E-20"},"ENSG00000139289","A0A024RBB0,Pleckstrin homology-like domain, family A, member 1, isoform CRA_a","-","-","IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","ENOG4111IXF,-;ENOG410IXHQ,-","-","-"]
["FAM127B",48.80603777,10.61992194,2.197398898,5.271635227,{"v":5.19e-13,"d":"5.19E-13"},{"v":9.98e-12,"d":"9.98E-12"},"ENSG00000203950","H2RG95,Retrotransposon Gag like 8A","XP_009437944.1,protein FAM127B isoform X2","PF16297,omain of unknown function (DUF4939)","IPR032567,LDOC1-related;IPR032549,Domain of unknown function DUF4939","ENOG410IXM4,-;ENOG41113F5,-","-","-"]
["CREBBP",35.69872698,7.783381603,2.197081652,8.400582578,2.37E-22,{"v":2.91e-20,"d":"2.91E-20"},"ENSG00000005339","K7DBC8,CREB binding protein","XP_523285.2,CREB-binding protein isoform X1","PF02172,KIX domain;PF02135,TAZ zinc finger;PF00569,Zinc finger, ZZ type;PF00439,Bromodomain;PF08214,Histone acetylation protein;PF09030,Creb binding;PF06001,omain of Unknown Function (DUF902)","IPR031162,CBP/p300-type histone acetyltransferase domain;IPR036529,Coactivator CBP, KIX domain superfamily;IPR018359,Bromodomain, conserved site;IPR036427,Bromodomain-like superfamily;IPR014744,Nuclear receptor coactivator, CREB-bp-like, interlocking;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR009110,Nuclear receptor coactivator, interlocking;IPR037073,Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily;IPR010303,CREB-binding protein/p300, atypical RING domain;IPR001487,Bromodomain;IPR035898,TAZ domain superfamily;IPR038547,CBP/p300, atypical RING domain superfamily;IPR000433,Zinc finger, ZZ-type;IPR013178,Histone acetyltransferase Rtt109/CBP;IPR000197,Zinc finger, TAZ-type;IPR003101,Coactivator CBP, KIX domain","KOG1778,CREB binding protein/P300 and related TAZ Zn-finger proteins;COG5076,Transcription factor involved in chromatin remodeling, contains bromodomain","GO:0034644,biological_process,cellular response to UV;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003712,molecular_function,transcription cofactor activity;GO:0003684,molecular_function,damaged DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0005634,cellular_component,nucleus;GO:0005737,cellular_component,cytoplasm;GO:0006473,biological_process,protein acetylation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000790,cellular_component,nuclear chromatin;GO:0003682,molecular_function,chromatin binding;GO:0018076,biological_process,N-terminal peptidyl-lysine acetylation;GO:0016740,molecular_function,transferase activity;GO:0001085,molecular_function,RNA polymerase II transcription factor binding;GO:0016604,cellular_component,nuclear body;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm;GO:0004402,molecular_function,histone acetyltransferase activity;GO:0043426,molecular_function,MRF binding;GO:0003713,molecular_function,transcription coactivator activity;GO:0000987,molecular_function,proximal promoter sequence-specific DNA binding;GO:0046872,molecular_function,metal ion binding;GO:0031648,biological_process,protein destabilization;GO:0000123,cellular_component,histone acetyltransferase complex;GO:0016573,biological_process,histone acetylation;GO:0002039,molecular_function,p53 binding;GO:0016407,molecular_function,acetyltransferase activity;GO:0001191,molecular_function,transcriptional repressor activity, RNA polymerase II transcription factor binding","-"]
["NFRKB",5.472641075,1.18962261,2.196590679,4.465613843,{"v":8.7e-10,"d":"8.70E-10"},{"v":8.11e-09,"d":"8.11E-09"},"ENSG00000170322","A0A024R3N2,Nuclear factor related to kappaB binding protein, isoform CRA_a","-","PF14465,NFRKB Winged Helix-like","IPR038106,NFRKB winged helix-like domain superfamily;IPR025220,NFRKB winged helix-like domain;IPR024867,Nuclear factor related to kappa-B-binding protein","KOG1927,R-kappa-B and related transcription factors;ENOG410YHF2,-","GO:0031011,cellular_component,Ino80 complex","-"]
["SPSB1",6.210388754,1.348012998,2.195412207,3.786083546,{"v":2.71e-07,"d":"2.71E-07"},{"v":1.44E-6,"d":"1.44E-06"},"ENSG00000171621","A0A024R4G8,SplA/ryanodine receptor domain and SOCS box containing 1, isoform CRA_a","NP_079382.2,SPRY domain-containing SOCS box protein 1","PF07525,SOCS box;PF00622,SPRY domain","IPR001870,B30.2/SPRY domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR001496,SOCS box domain;IPR003877,SPRY domain","ENOG410XQC1,-;KOG3953,SOCS box protein SSB-1, contains SPRY domain","-","-"]
["APOM",12.73129695,2.763426645,2.195412207,3.786083546,{"v":2.71e-07,"d":"2.71E-07"},{"v":1.44E-6,"d":"1.44E-06"},"ENSG00000204444","H2QSN2,Apolipoprotein M","XP_518354.2,apolipoprotein M isoform X1","PF11032,ApoM domain","IPR012674,Calycin;IPR022734,Apolipoprotein M","ENOG4111Z0U,-;ENOG410IG6S,-","GO:0034366,cellular_component,spherical high-density lipoprotein particle;GO:0016209,molecular_function,antioxidant activity;GO:0034445,biological_process,negative regulation of plasma lipoprotein oxidation;GO:0034362,cellular_component,low-density lipoprotein particle;GO:0034375,biological_process,high-density lipoprotein particle remodeling;GO:0034380,biological_process,high-density lipoprotein particle assembly;GO:0098869,biological_process,cellular oxidant detoxification;GO:0005543,molecular_function,phospholipid binding;GO:0034361,cellular_component,very-low-density lipoprotein particle;GO:0034384,biological_process,high-density lipoprotein particle clearance;GO:0005576,cellular_component,extracellular region;GO:0033344,biological_process,cholesterol efflux;GO:0043691,biological_process,reverse cholesterol transport;GO:0034364,cellular_component,high-density lipoprotein particle;GO:0034365,cellular_component,discoidal high-density lipoprotein particle;GO:0005319,molecular_function,lipid transporter activity;GO:0042157,biological_process,lipoprotein metabolic process","-"]
["PRSS8",31.95061755,6.966930394,2.19539896,5.898233292,{"v":1.34e-15,"d":"1.34E-15"},{"v":4.72e-14,"d":"4.72E-14"},"ENSG00000052344","H2QAZ8,Uncharacterized protein","XP_001157509.1,prostasin","PF00089,Trypsin","IPR001254,Serine proteases, trypsin domain;IPR018114,Serine proteases, trypsin family, histidine active site;IPR001314,Peptidase S1A, chymotrypsin family;IPR009003,Peptidase S1, PA clan;IPR033116,Serine proteases, trypsin family, serine active site","KOG3627,Trypsin;COG5640,Secreted trypsin-like serine protease","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0017080,molecular_function,sodium channel regulator activity;GO:0010765,biological_process,positive regulation of sodium ion transport;GO:0065009,biological_process,regulation of molecular function;GO:0046658,cellular_component,anchored component of plasma membrane;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0008236,molecular_function,serine-type peptidase activity;GO:0019897,cellular_component,extrinsic component of plasma membrane;GO:0008233,molecular_function,peptidase activity","-"]
["HMGA1",553.2913226,120.8144546,2.19510817,9.617367696,{"v":6.51e-24,"d":"6.51E-24"},{"v":9.98e-22,"d":"9.98E-22"},"ENSG00000137309","I7GET7,Macaca fascicularis brain cDNA clone: QtrA-16957, similar to human high mobility group AT-hook 1","XP_015305037.1,-","-","IPR000637,HMG-I/HMG-Y, DNA-binding, conserved site;IPR031079,High mobility group protein HMGA1, mammal;IPR000116,High mobility group protein HMGA;IPR017956,AT hook, DNA-binding motif","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0000785,cellular_component,chromatin;GO:0005634,cellular_component,nucleus","-"]
["MAPK8IP1",4.751918288,1.030388192,2.194594337,3.461558419,{"v":2.11e-06,"d":"2.11E-06"},{"v":9.32e-06,"d":"9.32E-06"},"ENSG00000121653","H2Q3H1,Uncharacterized protein","XP_001160866.1,C-Jun-amino-terminal kinase-interacting protein 1 isoform X1","PF14604,Variant SH3 domain;PF00640,Phosphotyrosine interaction domain (PTB/PID)","IPR001452,SH3 domain;IPR035638,JIP1, SH3 domain;IPR006020,PTB/PI domain;IPR011993,PH-like domain superfamily","ENOG410ZFRJ,-;KOG3775,Mitogen-activated protein kinase scaffold protein JIP","GO:0005886,cellular_component,plasma membrane;GO:0019901,molecular_function,protein kinase binding;GO:0019894,molecular_function,kinesin binding;GO:0007258,biological_process,JUN phosphorylation;GO:0030425,cellular_component,dendrite;GO:0005737,cellular_component,cytoplasm;GO:0030424,cellular_component,axon;GO:0016020,cellular_component,membrane;GO:0005078,molecular_function,MAP-kinase scaffold activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044302,cellular_component,dentate gyrus mossy fiber;GO:2001243,biological_process,negative regulation of intrinsic apoptotic signaling pathway;GO:0007165,biological_process,signal transduction;GO:0043005,cellular_component,neuron projection;GO:0005829,cellular_component,cytosol;GO:0016192,biological_process,vesicle-mediated transport;GO:0046328,biological_process,regulation of JNK cascade;GO:0044297,cellular_component,cell body;GO:0045202,cellular_component,synapse;GO:0043410,biological_process,positive regulation of MAPK cascade","K04434,ko04010,MAPK signaling pathway"]
["SLC12A7",2.777775764,0.602322509,2.194594337,3.461558419,{"v":2.11e-06,"d":"2.11E-06"},{"v":9.32e-06,"d":"9.32E-06"},"ENSG00000113504","A0A0G2JNW7,Solute carrier family 12 member 7","-","PF03522,Solute carrier family 12;PF00324,Amino acid permease","IPR004842,SLC12A transporter family;IPR018491,SLC12A transporter, C-terminal;IPR000076,K/Cl co-transporter;IPR004841,Amino acid permease/ SLC12A domain;IPR030354,K/Cl co-transporter 4","-","GO:1902476,biological_process,chloride transmembrane transport;GO:0055085,biological_process,transmembrane transport;GO:0006884,biological_process,cell volume homeostasis;GO:0015377,molecular_function,cation:chloride symporter activity;GO:0006811,biological_process,ion transport;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0015379,molecular_function,potassium:chloride symporter activity;GO:0016020,cellular_component,membrane;GO:0005215,molecular_function,transporter activity;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["N4BP3",2.733916146,0.592812154,2.194594337,3.461558419,{"v":2.11e-06,"d":"2.11E-06"},{"v":9.32e-06,"d":"9.32E-06"},"ENSG00000145911","H2R543,Uncharacterized protein","XP_016809868.1,-;XP_016809867.1,NEDD4-binding protein 3;XP_016809869.1,-;XP_016809870.1,-","PF06818,ez1","IPR033571,NEDD4-binding protein 3","ENOG410XQRF,-;ENOG410IE8K,-","-","-"]
["HERC4",2.277651422,0.496240467,2.193509932,4.521956243,{"v":3.87e-10,"d":"3.87E-10"},{"v":3.92e-09,"d":"3.92E-09"},"ENSG00000148634","K7BV16,Hect domain and RLD 4","XP_001167753.2,-","PF00632,HECT-domain (ubiquitin-transferase);PF00415,Regulator of chromosome condensation (RCC1) repeat","IPR000408,Regulator of chromosome condensation, RCC1;IPR000569,HECT domain;IPR009091,Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II;IPR035983,HECT, E3 ligase catalytic domain","KOG0941,E3 ubiquitin protein ligase;COG5021,Ubiquitin-protein ligase;COG5184,Alpha-tubulin suppressor and related RCC1 domain-containing proteins","GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016740,molecular_function,transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["RP5-956O18.3",11.76916172,2.547432032,2.193169907,3.040020499,{"v":3.25e-05,"d":"3.25E-05"},1.09844E-4,"ENSG00000224407","I7G413,Macaca fascicularis brain cDNA clone: QccE-17215, similar to human UDP-N-acetyl-alpha-D-galactosamine:polypeptideN- acetylgalactosaminyltransferase 2","-","-","-","-","GO:0016740,molecular_function,transferase activity","-"]
["ABTB2",2.435243798,0.527107895,2.193169907,3.040020499,{"v":3.25e-05,"d":"3.25E-05"},1.09844E-4,"ENSG00000166016","A0A0D9QZB0,Ankyrin repeat and BTB domain containing 2","XP_008000570.1,-","PF12796,Ankyrin repeats (3 copies);PF00651,BTB/POZ domain","IPR002110,Ankyrin repeat;IPR011333,SKP1/BTB/POZ domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR000210,BTB/POZ domain;IPR009072,Histone-fold","-","GO:0097237,biological_process,cellular response to toxic substance;GO:0005634,cellular_component,nucleus;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005654,cellular_component,nucleoplasm","-"]
["CAMK1D",3.604450961,0.785315264,2.19280839,4.337211953,{"v":3.69e-09,"d":"3.69E-09"},{"v":3e-08,"d":"3.00E-08"},"ENSG00000183049","H2N9S4,Calcium/calmodulin dependent protein kinase ID","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0032,Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily;ENOG410XRMJ,-","GO:0090023,biological_process,positive regulation of neutrophil chemotaxis;GO:0032793,biological_process,positive regulation of CREB transcription factor activity;GO:0005737,cellular_component,cytoplasm;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0050766,biological_process,positive regulation of phagocytosis;GO:0071622,biological_process,regulation of granulocyte chemotaxis;GO:0005524,molecular_function,ATP binding;GO:0050773,biological_process,regulation of dendrite development;GO:0010976,biological_process,positive regulation of neuron projection development;GO:0004672,molecular_function,protein kinase activity;GO:0060267,biological_process,positive regulation of respiratory burst;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["AREL1",4.321592682,0.941561624,2.19280839,4.337211953,{"v":3.69e-09,"d":"3.69E-09"},{"v":3e-08,"d":"3.00E-08"},"ENSG00000119682","H9YVJ3,Uncharacterized protein","NP_001247839.1,-;XP_014999600.1,-;XP_014999601.1,-","-","IPR013783,Immunoglobulin-like fold;IPR017868,Filamin/ABP280 repeat-like;IPR035983,HECT, E3 ligase catalytic domain;IPR000569,HECT domain;IPR014756,Immunoglobulin E-set","KOG0939,E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein;COG5021,Ubiquitin-protein ligase","GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016740,molecular_function,transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["SOWAHC",5.81285303,1.266468115,2.191873827,4.125014324,{"v":1.69e-08,"d":"1.69E-08"},{"v":1.18E-7,"d":"1.18E-07"},"ENSG00000198142","G3RED0,Sosondowah ankyrin repeat domain family member C","-","PF12796,Ankyrin repeats (3 copies)","-","-","-","-"]
["ZMYM4",27.01586588,5.913110425,2.190960362,6.988720846,{"v":3.31e-19,"d":"3.31E-19"},{"v":2.34e-17,"d":"2.34E-17"},"ENSG00000146463","H2PYM2,Zinc finger, MYM-type 4","XP_001166982.1,zinc finger MYM-type protein 4 isoform X2","PF06467,MYM-type Zinc finger with FCS sequence motif;PF12012,omain of unknown function (DUF3504)","IPR021893,Protein of unknown function DUF3504;IPR011017,TRASH domain;IPR010507,Zinc finger, MYM-type","ENOG410XQR6,-;ENOG410IE8I,-","GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0007010,biological_process,cytoskeleton organization;GO:0022604,biological_process,regulation of cell morphogenesis;GO:0007275,biological_process,multicellular organism development;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["TUBA1B",176.2679814,38.59717694,2.190922087,8.58902295,{"v":1.54e-22,"d":"1.54E-22"},1.94E-20,"ENSG00000123416","B0BMH2,Tubulin alpha chain","NP_001107705.1,-;XP_012811688.1,-","PF03953,Tubulin C-terminal domain;PF00091,Tubulin/FtsZ family, GTPase domain","IPR017975,Tubulin, conserved site;IPR003008,Tubulin/FtsZ, GTPase domain;IPR008280,Tubulin/FtsZ, C-terminal;IPR036525,Tubulin/FtsZ, GTPase domain superfamily;IPR037103,Tubulin/FtsZ, C-terminal domain superfamily;IPR018316,Tubulin/FtsZ, 2-layer sandwich domain;IPR002452,Alpha tubulin;IPR000217,Tubulin;IPR023123,Tubulin, C-terminal","KOG1376,Alpha tubulin;COG5023,Tubulin","GO:0005874,cellular_component,microtubule;GO:0005856,cellular_component,cytoskeleton;GO:0005525,molecular_function,GTP binding;GO:0007010,biological_process,cytoskeleton organization;GO:0007017,biological_process,microtubule-based process;GO:0005737,cellular_component,cytoplasm;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005200,molecular_function,structural constituent of cytoskeleton","K07374,ko04145,Phagosome;K07374,ko04210,Apoptosis;K07374,ko05130,Pathogenic Escherichia coli infection;K07374,ko04540,Gap junction"]
["LDLRAD3",1.660923421,0.358102126,2.190066468,2.436221632,0.00128011,0.003007857,"ENSG00000179241","H2Q3F1,Low density lipoprotein receptor class A domain containing 3","XP_001142392.2,-","PF00057,Low-density lipoprotein receptor domain class A","IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR036055,LDL receptor-like superfamily;IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site","ENOG410XSZY,-;ENOG410IPSZ,-","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0070613,biological_process,regulation of protein processing;GO:0016020,cellular_component,membrane;GO:0005886,cellular_component,plasma membrane;GO:0001540,molecular_function,amyloid-beta binding;GO:0016021,cellular_component,integral component of membrane","-"]
["KATNBL1",1.039355033,0.224089348,2.190066468,2.436221632,0.00128011,0.003007857,"ENSG00000134152","H2Q937,Chromosome 15 open reading frame 29","XP_001165269.1,-","PF13925,con80 domain of Katanin","IPR028021,Katanin p80 subunit, C-terminal","ENOG410IIPM,-;ENOG4111ZSI,-","GO:0051495,biological_process,positive regulation of cytoskeleton organization;GO:0097431,cellular_component,mitotic spindle pole;GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus","-"]
["USP43",1.499353719,0.323267014,2.190066468,2.436221632,0.00128011,0.003007857,"ENSG00000154914","H2R9J1,Ubiquitin specific peptidase 43","XP_511843.3,ubiquitin carboxyl-terminal hydrolase 43 isoform X1","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","KOG1868,Ubiquitin C-terminal hydrolase;COG5560,Ubiquitin C-terminal hydrolase;ENOG410XP8T,-;KOG1870,Ubiquitin C-terminal hydrolase","GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0005634,cellular_component,nucleus;GO:0016579,biological_process,protein deubiquitination","-"]
["USP38",0.975821838,0.210391322,2.190066468,2.436221632,0.00128011,0.003007857,"ENSG00000170185","K7CJ23,Ubiquitin specific peptidase 38","-","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR033840,Ubiquitin-specific peptidase 38;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","ENOG410XQ81,-;KOG1864,Ubiquitin-specific protease","GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016579,biological_process,protein deubiquitination","-"]
["BAALC-AS1",1.959949613,0.42257344,2.190066468,2.436221632,0.00128011,0.003007857,"ENSG00000247081","H2PQZ3,Uncharacterized protein","-","-","-","-","-","-"]
["PROSER1",10.03078399,2.194874752,2.18981087,5.516292097,{"v":4.52e-14,"d":"4.52E-14"},{"v":1.1E-12,"d":"1.10E-12"},"ENSG00000120685","G3QMM1,Proline and serine rich 1","XP_004054459.1,proline and serine-rich protein 1 isoform X1","PF14771,omain of unknown function (DUF4476)","IPR028011,Domain of unknown function DUF4476","-","-","-"]
["ATXN2L",53.05271224,11.63034048,2.189021074,7.725119585,{"v":4.69e-21,"d":"4.69E-21"},{"v":4.6e-19,"d":"4.60E-19"},"ENSG00000168488","F7FFI7,Ataxin 2 like","XP_014981355.1,-;XP_014981356.1,-","PF07145,Ataxin-2 C-terminal region;PF06741,LsmAD domain;PF14438,Ataxin 2 SM domain","IPR009604,LsmAD domain;IPR009818,Ataxin-2, C-terminal;IPR025852,Ataxin 2, SM domain","KOG2375,Protein interacting with poly(A)-binding protein;COG5180,Protein interacting with poly(A)-binding protein","GO:0010494,cellular_component,cytoplasmic stress granule;GO:0016020,cellular_component,membrane;GO:0010603,biological_process,regulation of cytoplasmic mRNA processing body assembly;GO:0034063,biological_process,stress granule assembly;GO:0016607,cellular_component,nuclear speck;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol","-"]
["KIAA1551",17.3289453,3.796281263,2.188989308,6.155366025,{"v":2.22e-16,"d":"2.22E-16"},{"v":9.04e-15,"d":"9.04E-15"},"ENSG00000174718","H2Q5P4,Chromosome 12 open reading frame 35","XP_016779171.1,-;XP_016779174.1,-;XP_016779172.1,-;XP_003313860.1,uncharacterized protein KIAA1551 homolog isoform X1;XP_016779173.1,-","PF15395,omain of unknown function (DUF4617)","IPR027866,Protein of unknown function DUF4617","ENOG410IKK4,-;ENOG41119UF,-","-","-"]
["PCDHA10",1.185428996,0.258273866,2.188610277,3.573233349,{"v":8.87e-07,"d":"8.87E-07"},{"v":4.23e-06,"d":"4.23E-06"},"ENSG00000250120","Q767I2,Cadherin-related neuronal receptor 10","XP_017456305.1,-;NP_446391.1,protocadherin alpha-10","PF08266,Cadherin-like;PF00028,Cadherin domain;PF15974,Cadherin C-terminal cytoplasmic tail, catenin-binding region","IPR031904,Cadherin, C-terminal catenin-binding domain;IPR002126,Cadherin;IPR013164,Cadherin, N-terminal;IPR015919,Cadherin-like;IPR020894,Cadherin conserved site","-","GO:0007283,biological_process,spermatogenesis;GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["RP1-101K10.6",8.40958576,1.832228025,2.188610277,3.573233349,{"v":8.87e-07,"d":"8.87E-07"},{"v":4.23e-06,"d":"4.23E-06"},"ENSG00000227627","H2QTX8,Mitochondrial translational release factor 1-like","XP_518818.2,peptide chain release factor 1-like, mitochondrial isoform X1","PF00472,RF-1 domain;PF03462,PCRF domain","IPR005139,Peptide chain release factor;IPR000352,Peptide chain release factor class I/class II","COG0216,Protein chain release factor A;KOG2726,Mitochondrial polypeptide chain release factor","GO:0005739,cellular_component,mitochondrion;GO:0003747,molecular_function,translation release factor activity;GO:0006415,biological_process,translational termination","-"]
["JMY",7.773523889,1.703183136,2.187820584,5.45596882,{"v":9.86e-14,"d":"9.86E-14"},{"v":2.24e-12,"d":"2.24E-12"},"ENSG00000152409","K7CXD1,Junction mediating and regulatory protein, p53 cofactor","-","PF15871,Junction-mediating and -regulatory protein;PF15920,N-terminal of Junction-mediating and WASP homolog-associated","IPR003124,WH2 domain;IPR031808,JMY/WHAMM, N-terminal;IPR031738,JMY/WHAMM, middle domain;IPR033324,Junction-mediating and -regulatory protein","ENOG4111J4B,-;ENOG410IF4S,-","GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0070060,biological_process,'de novo' actin filament nucleation;GO:0003713,molecular_function,transcription coactivator activity;GO:0003779,molecular_function,actin binding;GO:0034314,biological_process,Arp2/3 complex-mediated actin nucleation","-"]
["WHSC1L1",23.68062424,5.198961035,2.186923235,7.790161216,{"v":3.76e-21,"d":"3.76E-21"},{"v":3.76e-19,"d":"3.76E-19"},"ENSG00000147548","K7CZJ3,Histone-lysine N-methyltransferase","-","PF00856,SET domain;PF00855,PWWP domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR003616,Post-SET domain;IPR001214,SET domain;IPR006560,AWS domain;IPR019787,Zinc finger, PHD-finger;IPR000313,PWWP domain;IPR019786,Zinc finger, PHD-type, conserved site","COG2940,Proteins containing SET domain;KOG1081,Transcription factor NSD1 and related SET domain proteins","GO:0034968,biological_process,histone lysine methylation;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0005634,cellular_component,nucleus","-"]
["PHC1P1",4.421832173,0.963401178,2.185358219,3.188422188,{"v":1.89e-05,"d":"1.89E-05"},{"v":6.77e-05,"d":"6.77E-05"},"ENSG00000179899","B2RXH1,Polyhomeotic homolog 1","-","PF00536,SAM domain (Sterile alpha motif);PF16616,Unstructured region on Polyhomeotic-like protein 1 and 2","IPR038603,FCS-type zinc finger superfamily;IPR012313,Zinc finger, FCS-type;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","ENOG4111UWW,-;ENOG410IGCD,-","GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["KIAA1324L",5.706066338,1.251702624,2.184796176,4.870313988,3.12E-11,{"v":4.01e-10,"d":"4.01E-10"},"ENSG00000164659","H2RDC6,KIAA1324-like","XP_527807.3,UPF0577 protein KIAA1324-like homolog isoform X1","-","IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011641,Tyrosine-protein kinase ephrin type A/B receptor-like","ENOG410IR7A,-;ENOG410XVXU,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GATA3",59.56577884,13.09445062,2.184619133,6.89818671,{"v":6.33e-19,"d":"6.33E-19"},{"v":4.16e-17,"d":"4.16E-17"},"ENSG00000107485","H2R285,Uncharacterized protein","XP_016818112.1,-;XP_016818113.1,-;XP_507651.1,trans-acting T-cell-specific transcription factor GATA-3 isoform X1","PF00320,ATA zinc finger","IPR016374,Transcription factor, GATA-2/3;IPR029521,Transcription factor GATA-3;IPR000679,Zinc finger, GATA-type;IPR013088,Zinc finger, NHR/GATA-type","COG5641,GATA Zn-finger-containing transcription factor;KOG1601,GATA-4/5/6 transcription factors","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030154,biological_process,cell differentiation;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0045582,biological_process,positive regulation of T cell differentiation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0001085,molecular_function,RNA polymerase II transcription factor binding;GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["ANXA9",19.63662757,4.306638928,2.183996261,4.514362802,{"v":4.93e-10,"d":"4.93E-10"},{"v":4.89e-09,"d":"4.89E-09"},"ENSG00000143412","H2PZX5,Annexin","XP_016782215.1,annexin A9 isoform X1;XP_016782219.1,-","PF00191,Annexin","IPR037104,Annexin superfamily;IPR009116,Annexin A9;IPR001464,Annexin;IPR018252,Annexin repeat, conserved site;IPR018502,Annexin repeat","ENOG410XPUN,-;KOG0819,Annexin","GO:0009986,cellular_component,cell surface;GO:0098609,biological_process,cell-cell adhesion;GO:0005509,molecular_function,calcium ion binding;GO:0005544,molecular_function,calcium-dependent phospholipid binding;GO:0001786,molecular_function,phosphatidylserine binding;GO:0005829,cellular_component,cytosol;GO:0015464,molecular_function,acetylcholine receptor activity;GO:0005543,molecular_function,phospholipid binding;GO:0007165,biological_process,signal transduction","-"]
["WDR81",2.460726894,0.538307189,2.183519962,3.676770916,{"v":8.27e-07,"d":"8.27E-07"},{"v":3.97e-06,"d":"3.97E-06"},"ENSG00000167716","A0A0J9YXM6,WD repeat-containing protein 81","-","PF00400,WD domain, G-beta repeat;PF02138,Beige/BEACH domain","IPR017986,WD40-repeat-containing domain;IPR036372,BEACH domain superfamily;IPR000409,BEACH domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR001680,WD40 repeat","-","-","-"]
["ZNF12",10.13139378,2.226899004,2.182445996,5.07727601,{"v":4.24e-12,"d":"4.24E-12"},{"v":6.63e-11,"d":"6.63E-11"},"ENSG00000164631","H2PLG5,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0005622,cellular_component,intracellular;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005813,cellular_component,centrosome;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["PIAS1",8.153327186,1.793999931,2.182207763,5.772395939,{"v":5.59e-15,"d":"5.59E-15"},1.71E-13,"ENSG00000033800","H2RH26,Protein inhibitor of activated STAT 1","-","PF14324,PINIT domain;PF02891,MIZ/SP-RING zinc finger","IPR004181,Zinc finger, MIZ-type;IPR038654,PINIT domain superfamily;IPR023321,PINIT domain;IPR036361,SAP domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR003034,SAP domain","ENOG410XQ2E,-;KOG2169,Zn-finger transcription factor","GO:0008270,molecular_function,zinc ion binding","K04706,ko04630,Jak-STAT signaling pathway;K04706,ko04120,Ubiquitin mediated proteolysis;K04706,ko05160,Hepatitis C"]
["ARMC1",17.42253624,3.831200761,2.182135202,5.224672841,1.29E-12,{"v":2.28e-11,"d":"2.28E-11"},"ENSG00000104442","G7PBX8,Armadillo repeat-containing protein 1","XP_005563488.1,-","PF00514,Armadillo/beta-catenin-like repeat","IPR000225,Armadillo;IPR016617,Uncharacterised conserved protein UCP013899, metal binding;IPR036163,Heavy metal-associated domain superfamily;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","-","GO:0030001,biological_process,metal ion transport;GO:0046872,molecular_function,metal ion binding","-"]
["SEMA3A",24.75707629,5.454647042,2.181526065,7.156413547,{"v":1.47e-19,"d":"1.47E-19"},1.12E-17,"ENSG00000075213","H2QUV1,Uncharacterized protein","XP_009451745.2,-;XP_016813148.1,-;XP_009451742.2,semaphorin-3A isoform X1","PF01403,Sema domain","IPR001627,Sema domain;IPR036352,Sema domain superfamily;IPR016201,PSI domain;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR027231,Semaphorin;IPR007110,Immunoglobulin-like domain","KOG3611,Semaphorins;ENOG410XQZC,-","GO:0010977,biological_process,negative regulation of neuron projection development;GO:0045499,molecular_function,chemorepellent activity;GO:0007413,biological_process,axonal fasciculation;GO:0097490,biological_process,sympathetic neuron projection extension;GO:2000020,biological_process,positive regulation of male gonad development;GO:0010633,biological_process,negative regulation of epithelial cell migration;GO:0060666,biological_process,dichotomous subdivision of terminal units involved in salivary gland branching;GO:0048841,biological_process,regulation of axon extension involved in axon guidance;GO:0005615,cellular_component,extracellular space;GO:0021828,biological_process,gonadotrophin-releasing hormone neuronal migration to the hypothalamus;GO:1902287,biological_process,semaphorin-plexin signaling pathway involved in axon guidance;GO:0048813,biological_process,dendrite morphogenesis;GO:0048843,biological_process,negative regulation of axon extension involved in axon guidance;GO:0030215,molecular_function,semaphorin receptor binding;GO:0021612,biological_process,facial nerve structural organization;GO:0061551,biological_process,trigeminal ganglion development;GO:0030517,biological_process,negative regulation of axon extension;GO:0048846,biological_process,axon extension involved in axon guidance;GO:0050919,biological_process,negative chemotaxis;GO:0002027,biological_process,regulation of heart rate;GO:0021675,biological_process,nerve development;GO:0021785,biological_process,branchiomotor neuron axon guidance;GO:0021772,biological_process,olfactory bulb development;GO:1903045,biological_process,neural crest cell migration involved in sympathetic nervous system development;GO:0008045,biological_process,motor neuron axon guidance;GO:0030424,cellular_component,axon;GO:0150020,biological_process,basal dendrite arborization;GO:0007411,biological_process,axon guidance;GO:0038191,molecular_function,neuropilin binding;GO:0001764,biological_process,neuron migration;GO:0021637,biological_process,trigeminal nerve structural organization;GO:0060385,biological_process,axonogenesis involved in innervation;GO:1903375,biological_process,facioacoustic ganglion development;GO:1902285,biological_process,semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:0071526,biological_process,semaphorin-plexin signaling pathway;GO:0036486,biological_process,ventral trunk neural crest cell migration;GO:1901166,biological_process,neural crest cell migration involved in autonomic nervous system development;GO:0061549,biological_process,sympathetic ganglion development;GO:0097491,biological_process,sympathetic neuron projection guidance;GO:2001224,biological_process,positive regulation of neuron migration","-"]
["FOXP1",2.735635663,0.601084981,2.181517212,4.568859013,2.84E-10,{"v":2.95e-09,"d":"2.95E-09"},"ENSG00000114861","F7HDH6,Forkhead box P1","-","PF00250,orkhead domain;PF16159,OXP coiled-coil domain","IPR032354,FOXP, coiled-coil domain;IPR001766,Fork head domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR036390,Winged helix DNA-binding domain superfamily","COG5025,Transcription factor of the Forkhead/HNF3 family;KOG4385,Predicted forkhead transcription factor","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["ZNF385A",51.46588238,11.33783547,2.181397518,6.657025568,{"v":4.94e-18,"d":"4.94E-18"},2.82E-16,"ENSG00000161642","H2NHJ8,Zinc finger protein 385A","-","PF12874,Zinc-finger of C2H2 type","IPR013087,Zinc finger C2H2-type;IPR003604,Matrin/U1-C-like, C2H2-type zinc finger;IPR036236,Zinc finger C2H2 superfamily","ENOG410Y1ZH,-;ENOG410IHAD,-","GO:0003730,molecular_function,mRNA 3'-UTR binding;GO:0003676,molecular_function,nucleic acid binding;GO:0008298,biological_process,intracellular mRNA localization;GO:1902164,biological_process,positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0045600,biological_process,positive regulation of fat cell differentiation;GO:0030425,cellular_component,dendrite;GO:0000790,cellular_component,nuclear chromatin;GO:0006915,biological_process,apoptotic process;GO:1902166,biological_process,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000765,biological_process,regulation of cytoplasmic translation;GO:0035855,biological_process,megakaryocyte development;GO:0007626,biological_process,locomotory behavior;GO:0008270,molecular_function,zinc ion binding;GO:0043025,cellular_component,neuronal cell body;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0046872,molecular_function,metal ion binding;GO:0030220,biological_process,platelet formation;GO:0010609,biological_process,mRNA localization resulting in posttranscriptional regulation of gene expression;GO:0007611,biological_process,learning or memory;GO:0002039,molecular_function,p53 binding;GO:0007599,biological_process,hemostasis;GO:0070889,biological_process,platelet alpha granule organization","-"]
["PEG10",1847.851021,407.6076434,2.180581242,12.88120946,1.95E-24,{"v":3.26e-22,"d":"3.26E-22"},"ENSG00000242265","A0A087WX23,Retrotransposon-derived protein PEG10","-","PF16297,omain of unknown function (DUF4939);PF08284,Retroviral aspartyl protease","IPR021109,Aspartic peptidase domain superfamily;IPR032567,LDOC1-related;IPR001878,Zinc finger, CCHC-type;IPR032549,Domain of unknown function DUF4939;IPR036875,Zinc finger, CCHC-type superfamily","ENOG410Y6K0,-;ENOG410J3P7,-","GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["PDE8A",13.00821491,2.866951269,2.18012297,5.992469001,{"v":8.9e-16,"d":"8.90E-16"},{"v":3.27e-14,"d":"3.27E-14"},"ENSG00000073417","H2QA09,Phosphodiesterase","XP_001163046.1,high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1","PF00233,3'5'-cyclic nucleotide phosphodiesterase;PF00989,PAS fold","IPR000014,PAS domain;IPR023088,3'5'-cyclic nucleotide phosphodiesterase;IPR003607,HD/PDEase domain;IPR035965,PAS domain superfamily;IPR002073,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain;IPR013767,PAS fold;IPR023174,3'5'-cyclic nucleotide phosphodiesterase, conserved site;IPR036971,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily","ENOG410XP9B,-;KOG1229,3'5'-cyclic nucleotide phosphodiesterases","GO:0016787,molecular_function,hydrolase activity;GO:0004114,molecular_function,3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0060548,biological_process,negative regulation of cell death;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0019900,molecular_function,kinase binding;GO:1903206,biological_process,negative regulation of hydrogen peroxide-induced cell death;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0007165,biological_process,signal transduction;GO:0001934,biological_process,positive regulation of protein phosphorylation","K18437,ko05032,Morphine addiction;K18437,ko00230,Purine metabolism"]
["ZFYVE26",2.464408741,0.542420067,2.179224304,4.621359383,{"v":3.16e-10,"d":"3.16E-10"},{"v":3.26e-09,"d":"3.26E-09"},"ENSG00000072121","K6ZKU5,Zinc finger, FYVE domain containing 26","-","PF01363,YVE zinc finger","IPR017455,Zinc finger, FYVE-related;IPR011011,Zinc finger, FYVE/PHD-type;IPR028730,Zinc finger FYVE domain-containing protein 26;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000306,FYVE zinc finger","KOG1811,Predicted Zn2+-binding protein, contains FYVE domain;ENOG410XRV7,-","GO:0000910,biological_process,cytokinesis;GO:0046872,molecular_function,metal ion binding;GO:0032266,molecular_function,phosphatidylinositol-3-phosphate binding;GO:0000724,biological_process,double-strand break repair via homologous recombination","-"]
["PDGFB",3.97766263,0.871213627,2.179061914,3.322733113,{"v":7.34E-6,"d":"7.34E-06"},{"v":2.88e-05,"d":"2.88E-05"},"ENSG00000100311","A0A096NK54,Platelet derived growth factor subunit B","XP_003905609.1,-","PF04692,Platelet-derived growth factor, N terminal region;PF00341,PDGF/VEGF domain","IPR015583,Platelet-derived growth factor subunit B;IPR023581,Platelet-derived growth factor, conserved site;IPR000072,PDGF/VEGF domain;IPR029034,Cystine-knot cytokine;IPR006782,Platelet-derived growth factor, N-terminal","-","GO:0008083,molecular_function,growth factor activity;GO:0010512,biological_process,negative regulation of phosphatidylinositol biosynthetic process;GO:0043552,biological_process,positive regulation of phosphatidylinositol 3-kinase activity;GO:0045740,biological_process,positive regulation of DNA replication;GO:2000573,biological_process,positive regulation of DNA biosynthetic process;GO:0002548,biological_process,monocyte chemotaxis;GO:1902895,biological_process,positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1902894,biological_process,negative regulation of pri-miRNA transcription by RNA polymerase II;GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0048008,biological_process,platelet-derived growth factor receptor signaling pathway;GO:0046982,molecular_function,protein heterodimerization activity;GO:1900127,biological_process,positive regulation of hyaluronan biosynthetic process;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0009986,cellular_component,cell surface;GO:0090280,biological_process,positive regulation of calcium ion import;GO:0035793,biological_process,positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0048146,biological_process,positive regulation of fibroblast proliferation;GO:0050918,biological_process,positive chemotaxis;GO:0050921,biological_process,positive regulation of chemotaxis;GO:0042803,molecular_function,protein homodimerization activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0048407,molecular_function,platelet-derived growth factor binding;GO:0010544,biological_process,negative regulation of platelet activation;GO:0043406,biological_process,positive regulation of MAP kinase activity;GO:0001938,biological_process,positive regulation of endothelial cell proliferation;GO:1905064,biological_process,negative regulation of vascular smooth muscle cell differentiation;GO:0042802,molecular_function,identical protein binding;GO:0045737,biological_process,positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0070528,biological_process,protein kinase C signaling;GO:0061098,biological_process,positive regulation of protein tyrosine kinase activity;GO:0010628,biological_process,positive regulation of gene expression;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0060326,biological_process,cell chemotaxis;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0032147,biological_process,activation of protein kinase activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0005518,molecular_function,collagen binding;GO:0005161,molecular_function,platelet-derived growth factor receptor binding;GO:0072126,biological_process,positive regulation of glomerular mesangial cell proliferation;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0042056,molecular_function,chemoattractant activity;GO:0010629,biological_process,negative regulation of gene expression;GO:0035655,biological_process,interleukin-18-mediated signaling pathway;GO:1904754,biological_process,positive regulation of vascular associated smooth muscle cell migration;GO:0016176,molecular_function,superoxide-generating NADPH oxidase activator activity;GO:0031954,biological_process,positive regulation of protein autophosphorylation;GO:0006468,biological_process,protein phosphorylation;GO:0072593,biological_process,reactive oxygen species metabolic process;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:1905176,biological_process,positive regulation of vascular smooth muscle cell dedifferentiation;GO:0014911,biological_process,positive regulation of smooth muscle cell migration;GO:0071363,biological_process,cellular response to growth factor stimulus;GO:0045840,biological_process,positive regulation of mitotic nuclear division;GO:0043536,biological_process,positive regulation of blood vessel endothelial cell migration;GO:0032091,biological_process,negative regulation of protein binding;GO:0009611,biological_process,response to wounding;GO:2000379,biological_process,positive regulation of reactive oxygen species metabolic process;GO:0032148,biological_process,activation of protein kinase B activity;GO:0005622,cellular_component,intracellular;GO:0016020,cellular_component,membrane;GO:0030335,biological_process,positive regulation of cell migration;GO:1904707,biological_process,positive regulation of vascular smooth muscle cell proliferation;GO:2000591,biological_process,positive regulation of metanephric mesenchymal cell migration;GO:0043410,biological_process,positive regulation of MAPK cascade","-"]
["ARHGEF39",2.302953995,0.504408013,2.179061914,3.322733113,{"v":7.34E-6,"d":"7.34E-06"},{"v":2.88e-05,"d":"2.88E-05"},"ENSG00000137135","H2QX85,Uncharacterized protein","XP_016816310.1,-","PF00621,RhoGEF domain","IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR001849,Pleckstrin homology domain;IPR035899,Dbl homology (DH) domain superfamily","ENOG4110AJV,-;ENOG410IE9S,-","GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005886,cellular_component,plasma membrane;GO:0065009,biological_process,regulation of molecular function;GO:0030335,biological_process,positive regulation of cell migration","-"]
["RP11-334E6.10",17.79780182,3.877673906,2.1788883,2.657990105,0.00040416,1.069761E-3,"ENSG00000245385","G3SMI7,Ring finger protein 26","-","PF13920,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410ITZ8,-;ENOG410XVCP,-","GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0070979,biological_process,protein K11-linked ubiquitination;GO:0016567,biological_process,protein ubiquitination;GO:0032479,biological_process,regulation of type I interferon production;GO:0007032,biological_process,endosome organization;GO:0050687,biological_process,negative regulation of defense response to virus;GO:1905719,biological_process,protein localization to perinuclear region of cytoplasm;GO:0016020,cellular_component,membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["SLC25A19",2.721195875,0.592877162,2.1788883,2.657990105,0.00040416,1.069761E-3,"ENSG00000125454","Q5JPC1,Solute carrier family 25","XP_005257618.1,-;XP_016880415.1,-;NP_068380.3,mitochondrial thiamine pyrophosphate carrier;NP_001119594.1,-;XP_005257619.1,-;XP_005257616.1,-;XP_006722070.1,-;NP_001119593.1,-;XP_005257617.1,-","PF00153,Mitochondrial carrier protein","IPR018108,Mitochondrial substrate/solute carrier;IPR023395,Mitochondrial carrier domain superfamily;IPR002067,Mitochondrial carrier protein","ENOG410ZRF1,-;KOG0752,Mitochondrial solute carrier protein","GO:0055085,biological_process,transmembrane transport;GO:0005739,cellular_component,mitochondrion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ESRP2",11.48243377,2.532721218,2.177925298,5.322845337,{"v":3.66e-13,"d":"3.66E-13"},{"v":7.39e-12,"d":"7.39E-12"},"ENSG00000103067","G1QZ79,Epithelial splicing regulatory protein 2","XP_003262966.1,epithelial splicing regulatory protein 2 isoform X2","-","IPR034431,Epithelial splicing regulatory protein 2;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR036397,Ribonuclease H superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR012337,Ribonuclease H-like superfamily","ENOG410XPZU,-;KOG1365,RNA-binding protein Fusilli, contains RRM domain","GO:0043484,biological_process,regulation of RNA splicing;GO:0000380,biological_process,alternative mRNA splicing, via spliceosome;GO:0003676,molecular_function,nucleic acid binding;GO:0060445,biological_process,branching involved in salivary gland morphogenesis;GO:0050679,biological_process,positive regulation of epithelial cell proliferation;GO:0060441,biological_process,epithelial tube branching involved in lung morphogenesis;GO:0005634,cellular_component,nucleus;GO:0003729,molecular_function,mRNA binding;GO:0005654,cellular_component,nucleoplasm","-"]
["TP63",43.96230219,9.714733212,2.177486593,7.652210629,{"v":1.18e-20,"d":"1.18E-20"},1.08E-18,"ENSG00000073282","H2QNY5,Uncharacterized protein","XP_001160376.1,-","PF00870,P53 DNA-binding domain;PF07647,SAM domain (Sterile alpha motif);PF07710,P53 tetramerisation motif","IPR002117,p53 tumour suppressor family;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR011615,p53, DNA-binding domain;IPR008967,p53-like transcription factor, DNA-binding;IPR001660,Sterile alpha motif domain;IPR032645,Tumour protein p63;IPR012346,p53/RUNT-type transcription factor, DNA-binding domain superfamily;IPR037611,Tumour protein p63, SAM domain;IPR010991,p53, tetramerisation domain;IPR036674,p53-like tetramerisation domain superfamily","ENOG410IGE4,-;ENOG410XV9W,-","GO:0034644,biological_process,cellular response to UV;GO:0030855,biological_process,epithelial cell differentiation;GO:2000271,biological_process,positive regulation of fibroblast apoptotic process;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0048646,biological_process,anatomical structure formation involved in morphogenesis;GO:0010259,biological_process,multicellular organism aging;GO:0005634,cellular_component,nucleus;GO:0000785,cellular_component,chromatin;GO:0002064,biological_process,epithelial cell development;GO:0001501,biological_process,skeletal system development;GO:0048807,biological_process,female genitalia morphogenesis;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0060197,biological_process,cloacal septation;GO:0001738,biological_process,morphogenesis of a polarized epithelium;GO:0098773,biological_process,skin epidermis development;GO:0008544,biological_process,epidermis development;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0035115,biological_process,embryonic forelimb morphogenesis;GO:0031069,biological_process,hair follicle morphogenesis;GO:0005667,cellular_component,transcription factor complex;GO:0036342,biological_process,post-anal tail morphogenesis;GO:0002039,molecular_function,p53 binding;GO:0010332,biological_process,response to gamma radiation;GO:0009913,biological_process,epidermal cell differentiation;GO:0001942,biological_process,hair follicle development;GO:0045617,biological_process,negative regulation of keratinocyte differentiation;GO:0043281,biological_process,regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0030154,biological_process,cell differentiation;GO:0048485,biological_process,sympathetic nervous system development;GO:0007569,biological_process,cell aging;GO:0009887,biological_process,animal organ morphogenesis;GO:1904674,biological_process,positive regulation of somatic stem cell population maintenance;GO:0045747,biological_process,positive regulation of Notch signaling pathway;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0042475,biological_process,odontogenesis of dentin-containing tooth;GO:0003682,molecular_function,chromatin binding;GO:0007499,biological_process,ectoderm and mesoderm interaction;GO:0030425,cellular_component,dendrite;GO:0031571,biological_process,mitotic G1 DNA damage checkpoint;GO:0010165,biological_process,response to X-ray;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0043616,biological_process,keratinocyte proliferation;GO:0097371,molecular_function,MDM2/MDM4 family protein binding;GO:0060529,biological_process,squamous basal epithelial stem cell differentiation involved in prostate gland acinus development;GO:0030216,biological_process,keratinocyte differentiation;GO:0043523,biological_process,regulation of neuron apoptotic process;GO:0002053,biological_process,positive regulation of mesenchymal cell proliferation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0043589,biological_process,skin morphogenesis;GO:0030850,biological_process,prostate gland development;GO:0005794,cellular_component,Golgi apparatus;GO:1904888,biological_process,cranial skeletal system development;GO:0061436,biological_process,establishment of skin barrier;GO:0000989,molecular_function,transcription factor activity, transcription factor binding;GO:2000381,biological_process,negative regulation of mesoderm development;GO:0000790,cellular_component,nuclear chromatin;GO:0005654,cellular_component,nucleoplasm;GO:0042771,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0051402,biological_process,neuron apoptotic process;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006338,biological_process,chromatin remodeling;GO:0033147,biological_process,negative regulation of intracellular estrogen receptor signaling pathway;GO:0003690,molecular_function,double-stranded DNA binding;GO:0051289,biological_process,protein homotetramerization;GO:0035116,biological_process,embryonic hindlimb morphogenesis;GO:0007389,biological_process,pattern specification process;GO:0010482,biological_process,regulation of epidermal cell division;GO:0003684,molecular_function,damaged DNA binding;GO:0001736,biological_process,establishment of planar polarity;GO:0006915,biological_process,apoptotic process;GO:0045669,biological_process,positive regulation of osteoblast differentiation;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0060513,biological_process,prostatic bud formation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0030859,biological_process,polarized epithelial cell differentiation;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0006978,biological_process,DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0003677,molecular_function,DNA binding;GO:0050699,molecular_function,WW domain binding;GO:0010838,biological_process,positive regulation of keratinocyte proliferation;GO:2001235,biological_process,positive regulation of apoptotic signaling pathway;GO:0048745,biological_process,smooth muscle tissue development;GO:0060157,biological_process,urinary bladder development;GO:0051262,biological_process,protein tetramerization;GO:0008283,biological_process,cell proliferation;GO:0010481,biological_process,epidermal cell division;GO:0009954,biological_process,proximal/distal pattern formation;GO:0032502,biological_process,developmental process","-"]
["IL6ST",8.944366213,1.974725885,2.177220469,5.694581407,{"v":1.63e-14,"d":"1.63E-14"},{"v":4.43e-13,"d":"4.43E-13"},"ENSG00000134352","Q17RA0,Interleukin 6 signal transducer","NP_002175.2,interleukin-6 receptor subunit beta isoform 1 precursor","PF00041,ibronectin type III domain;PF09240,Interleukin-6 receptor alpha chain, binding;PF06328,Ig-like C2-type domain","IPR003529,Long hematopoietin receptor, Gp130 family 2, conserved site;IPR010457,Immunoglobulin C2-set-like, ligand-binding;IPR036116,Fibronectin type III superfamily;IPR003961,Fibronectin type III;IPR013783,Immunoglobulin-like fold;IPR015321,Type I cytokine receptor, cytokine-binding domain","ENOG410YNQ4,-;ENOG410IF1N,-","GO:0005515,molecular_function,protein binding;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0004896,molecular_function,cytokine receptor activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K05060,ko04630,Jak-STAT signaling pathway;K05060,ko04060,Cytokine-cytokine receptor interaction;K05060,ko04550,Signaling pathways regulating pluripotency of stem cells;K05060,ko05203,Viral carcinogenesis"]
["MANEAL",13.29713869,2.931382709,2.177097326,4.672005506,1.87E-10,{"v":2.01e-09,"d":"2.01E-09"},"ENSG00000185090","H2N7X7,Mannosidase endo-alpha like","XP_002811069.1,glycoprotein endo-alpha-1,2-mannosidase-like protein isoform X1","PF16317,lycosyl hydrolase family 99","IPR026071,Glycosyl hydrolase family 99","ENOG4111PYT,-;ENOG410IMQ9,-","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds","-"]
["ARMC10",7.465995834,1.645471449,2.176710995,4.449766015,{"v":1.12e-09,"d":"1.12E-09"},{"v":1.02E-8,"d":"1.02E-08"},"ENSG00000170632","H2QV63,Uncharacterized protein","XP_009452181.1,armadillo repeat-containing protein 10 isoform X2","PF04826,Armadillo-like","IPR011989,Armadillo-like helical;IPR006911,Armadillo repeat-containing domain;IPR016024,Armadillo-type fold","ENOG4112958,-;ENOG410IVCU,-","GO:0016021,cellular_component,integral component of membrane;GO:0005739,cellular_component,mitochondrion;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane","-"]
["RMI2",21.97891015,4.852476047,2.176379263,5.220040729,1.29E-12,{"v":2.28e-11,"d":"2.28E-11"},"ENSG00000175643","K7AJ48,Chromosome 16 open reading frame 75","XP_009428584.2,-","PF16100,RecQ-mediated genome instability protein 2","IPR032245,RecQ-mediated genome instability protein 2","ENOG41120UE,-;ENOG410IXR6,-","GO:0005829,cellular_component,cytosol;GO:0033045,biological_process,regulation of sister chromatid segregation;GO:0016607,cellular_component,nuclear speck","K15365,ko03460,Fanconi anemia pathway"]
["ADCY9",2.728109412,0.601043199,2.176162715,4.186567941,{"v":1.13E-8,"d":"1.13E-08"},{"v":8.28E-8,"d":"8.28E-08"},"ENSG00000162104","K7CYN2,Adenylate cyclase 9","XP_016784795.1,adenylate cyclase type 9 isoform X2","PF00211,Adenylate and Guanylate cyclase catalytic domain","IPR018297,Adenylyl cyclase class-4/guanylyl cyclase, conserved site;IPR001054,Adenylyl cyclase class-3/4/guanylyl cyclase;IPR029787,Nucleotide cyclase","KOG3618,Adenylyl cyclase;COG2114,Adenylate cyclase, family 3 (some proteins contain HAMP domain)","GO:0009190,biological_process,cyclic nucleotide biosynthetic process;GO:0006171,biological_process,cAMP biosynthetic process;GO:0071880,biological_process,adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0035556,biological_process,intracellular signal transduction;GO:0007189,biological_process,adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0004016,molecular_function,adenylate cyclase activity;GO:0005622,cellular_component,intracellular;GO:0016849,molecular_function,phosphorus-oxygen lyase activity;GO:0016020,cellular_component,membrane;GO:0000166,molecular_function,nucleotide binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016829,molecular_function,lyase activity","-"]
["STAT1",35.73867377,7.903331072,2.176145228,7.057238656,3.03E-19,{"v":2.18e-17,"d":"2.18E-17"},"ENSG00000115415","H2P855,Signal transducer and activator of transcription","-","PF12162,STAT1 TAZ2 binding domain;PF02865,STAT protein, protein interaction domain;PF01017,STAT protein, all-alpha domain;PF00017,SH2 domain;PF02864,STAT protein, DNA binding domain","IPR036860,SH2 domain superfamily;IPR015988,STAT transcription factor, coiled coil;IPR035859,STAT1, SH2 domain;IPR038295,STAT1, C-terminal domain superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR013801,STAT transcription factor, DNA-binding;IPR000980,SH2 domain;IPR012345,STAT transcription factor, DNA-binding, N-terminal;IPR013800,STAT transcription factor, all-alpha domain;IPR013799,STAT transcription factor, protein interaction;IPR022752,Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal;IPR001217,Transcription factor STAT;IPR036535,STAT transcription factor, N-terminal domain superfamily","KOG3667,STAT protein;ENOG410XPN8,-","GO:0051607,biological_process,defense response to virus;GO:0035458,biological_process,cellular response to interferon-beta;GO:0001937,biological_process,negative regulation of endothelial cell proliferation;GO:0032991,cellular_component,protein-containing complex;GO:0000790,cellular_component,nuclear chromatin;GO:0005164,molecular_function,tumor necrosis factor receptor binding;GO:0042393,molecular_function,histone binding;GO:0042802,molecular_function,identical protein binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003690,molecular_function,double-stranded DNA binding;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0010742,biological_process,macrophage derived foam cell differentiation;GO:0033209,biological_process,tumor necrosis factor-mediated signaling pathway;GO:0005634,cellular_component,nucleus;GO:0060337,biological_process,type I interferon signaling pathway;GO:0007259,biological_process,JAK-STAT cascade;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000983,molecular_function,transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0002230,biological_process,positive regulation of defense response to virus by host;GO:0005829,cellular_component,cytosol;GO:0001047,molecular_function,core promoter binding;GO:0060333,biological_process,interferon-gamma-mediated signaling pathway;GO:0003677,molecular_function,DNA binding;GO:0043124,biological_process,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035035,molecular_function,histone acetyltransferase binding;GO:0045296,molecular_function,cadherin binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0035456,biological_process,response to interferon-beta;GO:0004871,molecular_function,signal transducer activity;GO:0000979,molecular_function,RNA polymerase II core promoter sequence-specific DNA binding;GO:0046725,biological_process,negative regulation by virus of viral protein levels in host cell;GO:0045648,biological_process,positive regulation of erythrocyte differentiation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0007165,biological_process,signal transduction;GO:0005654,cellular_component,nucleoplasm;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0019899,molecular_function,enzyme binding;GO:0005730,cellular_component,nucleolus;GO:0032727,biological_process,positive regulation of interferon-alpha production;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0070491,molecular_function,repressing transcription factor binding;GO:0061326,biological_process,renal tubule development;GO:0044389,molecular_function,ubiquitin-like protein ligase binding;GO:0035257,molecular_function,nuclear hormone receptor binding;GO:0006351,biological_process,transcription, DNA-templated","-"]
["ARL2BP",48.15317099,10.64336017,2.17599217,6.009530244,{"v":8.17e-16,"d":"8.17E-16"},{"v":3.03e-14,"d":"3.03E-14"},"ENSG00000102931","H3BM52,ADP-ribosylation factor-like protein 2-binding protein","-","PF11527,The ARF-like 2 binding protein BART","IPR023379,ADP-ribosylation factor-like 2-binding protein, domain","ENOG410IKTQ,-;ENOG4111IGT,-","-","-"]
["MIDN",9.251007441,2.042425748,2.175118895,4.720924382,1.12E-10,{"v":1.26E-9,"d":"1.26E-09"},"ENSG00000167470","A0A0A0MXA6,Midnolin","-","PF00240,Ubiquitin family","-","-","-","-"]
["RC3H2",18.07946884,4.001779624,2.174802119,7.006306534,{"v":4.5e-19,"d":"4.50E-19"},{"v":3.05e-17,"d":"3.05E-17"},"ENSG00000056586","A0A024R899,Membrane associated DNA binding protein, isoform CRA_a","NP_001094058.1,roquin-2 isoform 1","PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar);PF13445,RING-type zinc-finger","IPR017907,Zinc finger, RING-type, conserved site;IPR036855,Zinc finger, CCCH-type superfamily;IPR001841,Zinc finger, RING-type;IPR032670,Roquin-2;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000571,Zinc finger, CCCH-type;IPR027370,RING-type zinc-finger, LisH dimerisation motif","ENOG410YWQD,-;KOG3161,Predicted E3 ubiquitin ligase","GO:1901224,biological_process,positive regulation of NIK/NF-kappaB signaling;GO:0048535,biological_process,lymph node development;GO:0009791,biological_process,post-embryonic development;GO:0016567,biological_process,protein ubiquitination;GO:0042098,biological_process,T cell proliferation;GO:0048536,biological_process,spleen development;GO:0035264,biological_process,multicellular organism growth;GO:0046872,molecular_function,metal ion binding;GO:0048286,biological_process,lung alveolus development;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0060173,biological_process,limb development;GO:0061470,biological_process,T follicular helper cell differentiation;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0010468,biological_process,regulation of gene expression;GO:0043029,biological_process,T cell homeostasis;GO:0010608,biological_process,posttranscriptional regulation of gene expression;GO:0003729,molecular_function,mRNA binding;GO:0001782,biological_process,B cell homeostasis","-"]
["PI4KB",20.89092187,4.624282491,2.174043456,6.143240764,{"v":3.54e-16,"d":"3.54E-16"},{"v":1.4E-14,"d":"1.40E-14"},"ENSG00000143393","A0A0B4J1S8,Phosphatidylinositol 4-kinase beta","NP_002642.1,phosphatidylinositol 4-kinase beta isoform 1","PF00454,Phosphatidylinositol 3- and 4-kinase","IPR018936,Phosphatidylinositol 3/4-kinase, conserved site;IPR000403,Phosphatidylinositol 3-/4-kinase, catalytic domain;IPR015433,Phosphatidylinositol kinase;IPR001263,Phosphoinositide 3-kinase, accessory (PIK) domain;IPR011009,Protein kinase-like domain superfamily;IPR036940,Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily","ENOG410XPH3,-;KOG0903,Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion","GO:0016301,molecular_function,kinase activity;GO:0016740,molecular_function,transferase activity;GO:0005622,cellular_component,intracellular;GO:0048015,biological_process,phosphatidylinositol-mediated signaling;GO:0016310,biological_process,phosphorylation;GO:0046854,biological_process,phosphatidylinositol phosphorylation","-"]
["LRIG2",1.315410246,0.289362387,2.173878983,3.445413531,{"v":2.95e-06,"d":"2.95E-06"},{"v":1.26E-5,"d":"1.26E-05"},"ENSG00000198799","H2N6C0,Leucine rich repeats and immunoglobulin like domains 2","-","PF13927,Immunoglobulin domain;PF01463,Leucine rich repeat C-terminal domain;PF13855,Leucine rich repeat;PF07679,Immunoglobulin I-set domain","IPR001611,Leucine-rich repeat;IPR007110,Immunoglobulin-like domain;IPR000483,Cysteine-rich flanking region, C-terminal;IPR032675,Leucine-rich repeat domain superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","KOG4194,Membrane glycoprotein LIG-1;COG4886,Leucine-rich repeat (LRR) protein","GO:0030426,cellular_component,growth cone;GO:0010977,biological_process,negative regulation of neuron projection development;GO:0016020,cellular_component,membrane;GO:0043025,cellular_component,neuronal cell body;GO:0097708,cellular_component,intracellular vesicle;GO:0007605,biological_process,sensory perception of sound;GO:0060384,biological_process,innervation;GO:0005102,molecular_function,signaling receptor binding;GO:2000010,biological_process,positive regulation of protein localization to cell surface;GO:0051045,biological_process,negative regulation of membrane protein ectodomain proteolysis;GO:0016021,cellular_component,integral component of membrane;GO:0048679,biological_process,regulation of axon regeneration;GO:0048681,biological_process,negative regulation of axon regeneration;GO:0010640,biological_process,regulation of platelet-derived growth factor receptor signaling pathway;GO:2001222,biological_process,regulation of neuron migration;GO:0043005,cellular_component,neuron projection","-"]
["TLR6",2.714954437,0.59723246,2.173878983,3.445413531,{"v":2.95e-06,"d":"2.95E-06"},{"v":1.26E-5,"d":"1.26E-05"},"ENSG00000174130","D1CS92,Toll-like receptor","-","PF01463,Leucine rich repeat C-terminal domain;PF13855,Leucine rich repeat;PF01582,TIR domain","IPR001611,Leucine-rich repeat;IPR000483,Cysteine-rich flanking region, C-terminal;IPR032675,Leucine-rich repeat domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR035897,Toll/interleukin-1 receptor homology (TIR) domain superfamily;IPR027187,Toll-like receptor 6;IPR000157,Toll/interleukin-1 receptor homology (TIR) domain","KOG4641,FOG: Toll/interleukin receptor and related proteins containing LRR and TIR repeats;COG4886,Leucine-rich repeat (LRR) protein","GO:0002376,biological_process,immune system process;GO:0042496,biological_process,detection of diacyl bacterial lipopeptide;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0050707,biological_process,regulation of cytokine secretion;GO:0045087,biological_process,innate immune response;GO:0034150,biological_process,toll-like receptor 6 signaling pathway;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0045410,biological_process,positive regulation of interleukin-6 biosynthetic process;GO:0002755,biological_process,MyD88-dependent toll-like receptor signaling pathway;GO:0042088,biological_process,T-helper 1 type immune response;GO:0016021,cellular_component,integral component of membrane;GO:0006954,biological_process,inflammatory response","-"]
["RHBDD2",6.712310539,1.476566119,2.173878983,3.445413531,{"v":2.95e-06,"d":"2.95E-06"},{"v":1.26E-5,"d":"1.26E-05"},"ENSG00000005486","H2QUS6,Rhomboid domain containing 2","XP_519156.1,-","PF01694,Rhomboid family","IPR022764,Peptidase S54, rhomboid domain;IPR035952,Rhomboid-like superfamily","ENOG41100KJ,-;KOG2632,Rhomboid family proteins","GO:0006508,biological_process,proteolysis;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GDE1",39.20028214,8.681300515,2.173873046,6.738951752,{"v":2.92e-18,"d":"2.92E-18"},1.76E-16,"ENSG00000006007","B2R7B1,cDNA, FLJ93361, highly similar to Homo sapiens membrane interacting protein of RGS16","-","PF03009,lycerophosphoryl diester phosphodiesterase family","IPR030395,Glycerophosphodiester phosphodiesterase domain;IPR004129,Glycerophosphoryl diester phosphodiesterase;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily","KOG2258,Glycerophosphoryl diester phosphodiesterase;COG0584,Glycerophosphoryl diester phosphodiesterase","GO:0008889,molecular_function,glycerophosphodiester phosphodiesterase activity;GO:0006629,biological_process,lipid metabolic process;GO:0008081,molecular_function,phosphoric diester hydrolase activity","-"]
["MFHAS1",4.312439076,0.952094857,2.173441086,4.254762199,{"v":5.91e-09,"d":"5.91E-09"},{"v":4.58E-8,"d":"4.58E-08"},"ENSG00000147324","G1RY51,Malignant fibrous histiocytoma amplified sequence 1","-","PF13855,Leucine rich repeat;PF08477,Ras of Complex, Roc, domain of DAPkinase","IPR001611,Leucine-rich repeat;IPR020859,Roc domain;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","-","-"]
["TGIF1",15.65353913,3.467127186,2.173321065,6.316240822,9.07E-17,{"v":4.01e-15,"d":"4.01E-15"},"ENSG00000177426","G3RAB7,Uncharacterized protein","-","PF05920,Homeobox KN domain","IPR008422,Homeobox KN domain;IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["MALT1",2.188572768,0.483190334,2.171975512,3.948665153,{"v":5.94e-08,"d":"5.94E-08"},{"v":3.68e-07,"d":"3.68E-07"},"ENSG00000172175","A8K5S1,cDNA FLJ78650, highly similar to Homo sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1","NP_776216.1,mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform b;NP_006776.1,mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform a","PF13927,Immunoglobulin domain;PF00656,Caspase domain;PF13895,Immunoglobulin domain","IPR036179,Immunoglobulin-like domain superfamily;IPR033540,Mucosa-associated lymphoid tissue lymphoma translocation protein 1;IPR011029,Death-like domain superfamily;IPR037940,MALT1, death domain;IPR001309,Peptidase C14,  p20 domain;IPR029030,Caspase-like domain superfamily;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR007110,Immunoglobulin-like domain;IPR013783,Immunoglobulin-like fold","ENOG410IG3U,-;COG4249,Uncharacterized protein containing caspase domain","GO:0004197,molecular_function,cysteine-type endopeptidase activity;GO:0006508,biological_process,proteolysis;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity","K07369,ko04662,B cell receptor signaling pathway;K07369,ko04064,NF-kappa B signaling pathway;K07369,ko04660,T cell receptor signaling pathway;K07369,ko05152,Tuberculosis"]
["ZBTB24",4.302593682,0.949921203,2.171975512,3.948665153,{"v":5.94e-08,"d":"5.94E-08"},{"v":3.68e-07,"d":"3.68E-07"},"ENSG00000112365","H2QTJ2,Zinc finger and BTB domain containing 24","XP_016811622.1,zinc finger and BTB domain-containing protein 24 isoform X1","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0003676,molecular_function,nucleic acid binding","-"]
["TCF20",16.64234458,3.689903661,2.171817036,6.281936313,{"v":9.78e-17,"d":"9.78E-17"},{"v":4.28e-15,"d":"4.28E-15"},"ENSG00000100207","W5ZR30,Transcription factor 20","XP_005261779.1,-;NP_005641.1,transcription factor 20 isoform 1;XP_006724376.1,-","PF13771,PHD-like zinc-binding domain","IPR034732,Extended PHD (ePHD) domain;IPR001965,Zinc finger, PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410IPTF,-;ENOG410ZTQQ,-","GO:0016604,cellular_component,nuclear body;GO:0046872,molecular_function,metal ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["RAPH1",5.562458734,1.232554637,2.171393885,5.349904749,3.09E-13,{"v":6.37e-12,"d":"6.37E-12"},"ENSG00000173166","C9K0J5,Ras association","XP_005246834.1,ras-associated and pleckstrin homology domains-containing protein 1 isoform X1;XP_006712758.1,-;XP_011509948.1,-;XP_005246836.1,-","PF00788,Ras association (RalGDS/AF-6) domain;PF00169,PH domain","IPR000159,Ras-associating (RA) domain;IPR029071,Ubiquitin-like domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","ENOG410XXC8,-;KOG3751,Growth factor receptor-bound proteins (GRB7, GRB10, GRB14)","GO:0005886,cellular_component,plasma membrane;GO:0016604,cellular_component,nuclear body;GO:0007165,biological_process,signal transduction;GO:0005829,cellular_component,cytosol","-"]
["HOXB3",1.4013206,0.307623943,2.170802865,2.849534785,1.34587E-4,0.000396686,"ENSG00000120093","H2REY9,Homeobox B3","-","PF13293,omain of unknown function (DUF4074);PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR025281,Domain of unknown function DUF4074;IPR001356,Homeobox domain;IPR020479,Homeobox domain, metazoa;IPR009057,Homeobox-like domain superfamily","ENOG410ZTBY,-;KOG0489,Transcription factor zerknullt and related HOX domain proteins","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0007275,biological_process,multicellular organism development;GO:0005634,cellular_component,nucleus","-"]
["NOMO3",8.38027102,1.861274102,2.16820145,5.440146315,{"v":1.62e-13,"d":"1.62E-13"},{"v":3.52e-12,"d":"3.52E-12"},"ENSG00000103226","J3KN36,Nodal modulator 3","XP_005255375.1,nodal modulator 3 isoform X1","PF13620,Carboxypeptidase regulatory-like domain","IPR008969,Carboxypeptidase-like, regulatory domain superfamily;IPR013784,Carbohydrate-binding-like fold","KOG1948,Metalloproteinase-related collagenase pM5;ENOG410XTI0,-","GO:0030246,molecular_function,carbohydrate binding","-"]
["SIK3",7.154247967,1.590307929,2.167272829,5.608785911,{"v":3.66e-14,"d":"3.66E-14"},{"v":9.22e-13,"d":"9.22E-13"},"ENSG00000160584","H0Y4E8,Serine/threonine-protein kinase SIK3","-","PF00069,Protein kinase domain","IPR015940,Ubiquitin-associated domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR034672,Salt-Inducible kinase, catalytic domain;IPR000719,Protein kinase domain","KOG0586,Serine/threonine protein kinase;ENOG410XNQ0,-","GO:0005654,cellular_component,nucleoplasm;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0004672,molecular_function,protein kinase activity","-"]
["SRPRA",18.7483532,4.167545618,2.167272829,5.608785911,{"v":3.66e-14,"d":"3.66E-14"},{"v":9.22e-13,"d":"9.22E-13"},"ENSG00000182934","K7D648,Signal recognition particle receptor","XP_016777976.1,-","PF04086,Signal recognition particle, alpha subunit, N-terminal;PF00448,SRP54-type protein, GTPase domain;PF02881,SRP54-type protein, helical bundle domain","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR007222,Signal recognition particle receptor, alpha subunit, N-terminal;IPR011012,Longin-like domain superfamily;IPR036225,SRP/SRP receptor, N-terminal;IPR003593,AAA+ ATPase domain;IPR000897,Signal recognition particle, SRP54 subunit, GTPase domain;IPR013822,Signal recognition particle, SRP54 subunit, helical bundle","KOG0781,Signal recognition particle receptor, alpha subunit;COG0552,Signal recognition particle GTPase","GO:0006614,biological_process,SRP-dependent cotranslational protein targeting to membrane;GO:0005047,molecular_function,signal recognition particle binding;GO:0005785,cellular_component,signal recognition particle receptor complex;GO:0005525,molecular_function,GTP binding;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0006886,biological_process,intracellular protein transport","K13431,ko03060,Protein export"]
["CBFA2T3",5.686001469,1.261932223,2.166667476,4.441774644,{"v":1.43E-9,"d":"1.43E-09"},{"v":1.27E-8,"d":"1.27E-08"},"ENSG00000129993","B2RBQ7,cDNA, FLJ95635, highly similar to Homo sapiens core-binding factor, runt domain, alpha subunit 2; translocated to, 3","-","PF08788,NHR2 domain like;PF01753,MYND finger;PF07531,NHR1 homology to TAF","IPR002893,Zinc finger, MYND-type;IPR037249,TAFH/NHR1 domain superfamily;IPR003894,TAFH/NHR1;IPR014896,NHR2-like;IPR013292,Protein CBFA2T3;IPR013289,CBFA2T family","ENOG410IG1Z,-;ENOG410XR30,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003714,molecular_function,transcription corepressor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0046872,molecular_function,metal ion binding","-"]
["CSNK2A2",31.1225824,6.928148151,2.166613488,7.049481151,{"v":4.31e-19,"d":"4.31E-19"},{"v":2.94e-17,"d":"2.94E-17"},"ENSG00000070770","H9ENR6,Casein kinase 2 alpha 2","XP_014981766.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0668,Casein kinase II, alpha subunit;ENOG410XNPP,-","GO:1905818,biological_process,regulation of chromosome separation;GO:0016301,molecular_function,kinase activity;GO:1903146,biological_process,regulation of autophagy of mitochondrion;GO:0005634,cellular_component,nucleus;GO:0005524,molecular_function,ATP binding;GO:0047485,molecular_function,protein N-terminus binding;GO:1903955,biological_process,positive regulation of protein targeting to mitochondrion;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0051726,biological_process,regulation of cell cycle;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0031519,cellular_component,PcG protein complex;GO:0004672,molecular_function,protein kinase activity","K03097,ko04064,NF-kappa B signaling pathway;K03097,ko05162,Measles;K03097,ko04712,Circadian rhythm - plant;K03097,ko04530,Tight junction;K03097,ko05168,Herpes simplex infection;K03097,ko05169,Epstein-Barr virus infection;K03097,ko04310,Wnt signaling pathway;K03097,ko04520,Adherens junction;K03097,ko03008,Ribosome biogenesis in eukaryotes;K03097,ko04139,Regulation of mitophagy - yeast"]
["BCAS3",1.886074482,0.418264096,2.16637145,4.104827329,{"v":2.93e-08,"d":"2.93E-08"},{"v":1.94e-07,"d":"1.94E-07"},"ENSG00000141376","H9FW69,Breast carcinoma-amplified sequence 3 isoform 1","-","PF12490,Breast carcinoma amplified sequence 3","IPR022175,Breast carcinoma amplified sequence 3;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily","-","-","-"]
["RCOR1",6.891781063,1.532125106,2.165287594,4.761846761,{"v":6.81e-11,"d":"6.81E-11"},{"v":8.05e-10,"d":"8.05E-10"},"ENSG00000089902","H2R956,Uncharacterized protein","XP_522957.3,REST corepressor 1 isoform X2","PF01448,LM2 domain;PF00249,Myb-like DNA-binding domain","IPR009057,Homeobox-like domain superfamily;IPR017884,SANT domain;IPR000949,ELM2 domain;IPR001005,SANT/Myb domain","KOG1194,Predicted DNA-binding protein, contains Myb-like, SANT and ELM2 domains;ENOG410XSIS,-","GO:1990391,cellular_component,DNA repair complex;GO:0003677,molecular_function,DNA binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0017053,cellular_component,transcriptional repressor complex;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0003714,molecular_function,transcription corepressor activity;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0008134,molecular_function,transcription factor binding;GO:0070933,biological_process,histone H4 deacetylation;GO:0005634,cellular_component,nucleus","-"]
["C5orf24",7.445188321,1.655154138,2.165287594,4.761846761,{"v":6.81e-11,"d":"6.81E-11"},{"v":8.05e-10,"d":"8.05E-10"},"ENSG00000181904","F6XPU3,Chromosome 5 open reading frame 24","XP_014996350.1,-;NP_001181812.1,-","-","-","ENOG410IFPQ,-;ENOG4111J4R,-","-","-"]
["EGFR-AS1",59.74585266,13.31205728,2.165072407,6.694724174,{"v":6.38e-18,"d":"6.38E-18"},3.52E-16,"ENSG00000224057","A0A099ZAF8,Epidermal growth factor receptor","-","PF14843,rowth factor receptor domain IV;PF00757,urin-like cysteine rich region;PF01030,Receptor L domain;PF07714,Protein tyrosine kinase","IPR032778,Growth factor receptor domain 4;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR006212,Furin-like repeat;IPR000494,Receptor L-domain;IPR016245,Tyrosine protein kinase, EGF/ERB/XmrK receptor;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR006211,Furin-like cysteine-rich domain;IPR036941,Receptor L-domain superfamily;IPR000719,Protein kinase domain","-","GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0035556,biological_process,intracellular signal transduction;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0004714,molecular_function,transmembrane receptor protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0004716,molecular_function,signal transducer, downstream of receptor, with protein tyrosine kinase activity;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane;GO:0023014,biological_process,signal transduction by protein phosphorylation","-"]
["CEP192",8.322257389,1.853262592,2.164806373,5.684556466,{"v":2.18e-14,"d":"2.18E-14"},{"v":5.72e-13,"d":"5.72E-13"},"ENSG00000101639","K7C3L6,Centrosomal protein 192kDa","XP_016788736.1,centrosomal protein of 192 kDa isoform X5","-","IPR013783,Immunoglobulin-like fold","ENOG410IG8G,-;ENOG4110RMB,-","-","-"]
["RP3-467L1.4",14.30482803,3.15820188,2.164682528,3.018150785,{"v":3.25e-05,"d":"3.25E-05"},1.09844E-4,"ENSG00000236266","A2I2N5,Period 3","NP_058515.1,period circadian protein homolog 3 isoform 4","PF08447,PAS fold;PF12114,Period protein 2/3C-terminal region","IPR000014,PAS domain;IPR035965,PAS domain superfamily;IPR015524,Period circadian protein 3;IPR013655,PAS fold-3;IPR022728,Period circadian-like, C-terminal","ENOG410Y118,-;KOG3753,Circadian clock protein period","GO:0032922,biological_process,circadian regulation of gene expression","-"]
["C14orf79",2.272345888,0.501685658,2.164682528,3.018150785,{"v":3.25e-05,"d":"3.25E-05"},1.09844E-4,"ENSG00000140104","K7DNZ0,Chromosome 14 open reading frame 79","XP_016782317.1,uncharacterized protein C14orf79 homolog isoform X1","PF15045,Clathrin-binding box of Aftiphilin, vesicle trafficking","IPR029205,Aftiphilin, clathrin-binding box","ENOG410YT97,-;ENOG410IVKE,-","-","-"]
["AC091729.9",5.930573059,1.309344436,2.164682528,3.018150785,{"v":3.25e-05,"d":"3.25E-05"},1.09844E-4,"-","-","-","-","-","-","-","-"]
["ZNRF2",3.21239374,0.709228236,2.164682528,3.018150785,{"v":3.25e-05,"d":"3.25E-05"},1.09844E-4,"ENSG00000180233","A0A090N8Y8,Zinc and ring finger 2, isoform CRA_b","NP_667339.1,E3 ubiquitin-protein ligase ZNRF2","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG0801,Predicted E3 ubiquitin ligase;ENOG4111V18,-","-","-"]
["PSMD5",11.94801724,2.661526178,2.163179374,5.061809557,{"v":7.61e-12,"d":"7.61E-12"},1.12E-10,"ENSG00000095261","A8K4T6,cDNA FLJ76282, highly similar to Homo sapiens proteasome","-","PF10508,Proteasome non-ATPase 26S subunit","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR019538,26S proteasome non-ATPase regulatory subunit 5","KOG4413,26S proteasome regulatory complex, subunit PSMD5;ENOG410XTFA,-","GO:0000502,cellular_component,proteasome complex;GO:0043248,biological_process,proteasome assembly","-"]
["CITED2",24.3548867,5.428743469,2.162721267,5.277551839,{"v":8.86e-13,"d":"8.86E-13"},{"v":1.63e-11,"d":"1.63E-11"},"ENSG00000164442","A0A0A0MTM3,Cbp/p300-interacting transactivator 2","NP_001161861.2,cbp/p300-interacting transactivator 2 isoform 2","PF04487,CITED","IPR007576,CITED","ENOG410IH9P,-;ENOG410Y09Y,-","GO:0046697,biological_process,decidualization;GO:0061308,biological_process,cardiac neural crest cell development involved in heart development;GO:0001570,biological_process,vasculogenesis;GO:0003197,biological_process,endocardial cushion development;GO:0007422,biological_process,peripheral nervous system development;GO:0003713,molecular_function,transcription coactivator activity;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0045787,biological_process,positive regulation of cell cycle;GO:0046332,molecular_function,SMAD binding;GO:0003281,biological_process,ventricular septum development;GO:0060044,biological_process,negative regulation of cardiac muscle cell proliferation;GO:0007569,biological_process,cell aging;GO:0009612,biological_process,response to mechanical stimulus;GO:0001947,biological_process,heart looping;GO:0007417,biological_process,central nervous system development;GO:0005634,cellular_component,nucleus;GO:0021602,biological_process,cranial nerve morphogenesis;GO:0007368,biological_process,determination of left/right symmetry;GO:1900164,biological_process,nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry;GO:0007507,biological_process,heart development;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0048821,biological_process,erythrocyte development;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0008584,biological_process,male gonad development;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0002089,biological_process,lens morphogenesis in camera-type eye;GO:0022409,biological_process,positive regulation of cell-cell adhesion;GO:0030511,biological_process,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0001843,biological_process,neural tube closure;GO:0003682,molecular_function,chromatin binding;GO:0060412,biological_process,ventricular septum morphogenesis;GO:0061371,biological_process,determination of heart left/right asymmetry;GO:0010628,biological_process,positive regulation of gene expression;GO:0001841,biological_process,neural tube formation;GO:0060411,biological_process,cardiac septum morphogenesis;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030325,biological_process,adrenal gland development;GO:0060971,biological_process,embryonic heart tube left/right pattern formation;GO:0010629,biological_process,negative regulation of gene expression;GO:0000790,cellular_component,nuclear chromatin;GO:0001829,biological_process,trophectodermal cell differentiation;GO:0060349,biological_process,bone morphogenesis;GO:0035802,biological_process,adrenal cortex formation;GO:0007530,biological_process,sex determination;GO:0001102,molecular_function,RNA polymerase II activating transcription factor binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:2000020,biological_process,positive regulation of male gonad development;GO:0048538,biological_process,thymus development;GO:0003151,biological_process,outflow tract morphogenesis;GO:0061156,biological_process,pulmonary artery morphogenesis;GO:0048596,biological_process,embryonic camera-type eye morphogenesis;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001889,biological_process,liver development;GO:0001944,biological_process,vasculature development;GO:0048536,biological_process,spleen development;GO:0071363,biological_process,cellular response to growth factor stimulus;GO:0001892,biological_process,embryonic placenta development;GO:0001701,biological_process,in utero embryonic development;GO:0001105,molecular_function,RNA polymerase II transcription coactivator activity;GO:0001568,biological_process,blood vessel development;GO:0002521,biological_process,leukocyte differentiation;GO:0003156,biological_process,regulation of animal organ formation;GO:0060136,biological_process,embryonic process involved in female pregnancy;GO:0030851,biological_process,granulocyte differentiation;GO:0070986,biological_process,left/right axis specification","-"]
["SNAI2",27.05505599,6.030615554,2.162721267,5.277551839,{"v":8.86e-13,"d":"8.86E-13"},{"v":1.63e-11,"d":"1.63E-11"},"ENSG00000019549","H2QW52,Snail family transcriptional repressor 2","XP_016814946.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG2462,C2H2-type Zn-finger protein;ENOG41106JS,-","GO:2000810,biological_process,regulation of bicellular tight junction assembly;GO:0043473,biological_process,pigmentation;GO:0043518,biological_process,negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0035414,-,-;GO:0070563,biological_process,negative regulation of vitamin D receptor signaling pathway;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:1902230,biological_process,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0001649,biological_process,osteoblast differentiation;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:0001837,biological_process,epithelial to mesenchymal transition;GO:0010839,biological_process,negative regulation of keratinocyte proliferation;GO:0005634,cellular_component,nucleus;GO:2000811,biological_process,negative regulation of anoikis;GO:0032331,biological_process,negative regulation of chondrocyte differentiation;GO:0014032,biological_process,neural crest cell development;GO:0032642,biological_process,regulation of chemokine production;GO:0007605,biological_process,sensory perception of sound;GO:0035921,biological_process,desmosome disassembly;GO:0010957,biological_process,negative regulation of vitamin D biosynthetic process;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0000790,cellular_component,nuclear chromatin;GO:0030335,biological_process,positive regulation of cell migration;GO:1900387,biological_process,negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0007219,biological_process,Notch signaling pathway;GO:0045667,biological_process,regulation of osteoblast differentiation","K05706,ko04520,Adherens junction;K05706,ko04390,Hippo signaling pathway"]
["IKBKE",5.449494234,1.210047014,2.162676199,3.760364925,{"v":3.69e-07,"d":"3.69E-07"},{"v":1.9E-6,"d":"1.90E-06"},"ENSG00000263528","K7C5W4,Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon","XP_016792928.1,-;XP_016792932.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR000719,Protein kinase domain","ENOG410XRMU,-;KOG4250,TANK binding protein kinase TBK1","GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0038061,biological_process,NIK/NF-kappaB signaling;GO:0051260,biological_process,protein homooligomerization;GO:0004672,molecular_function,protein kinase activity;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0005634,cellular_component,nucleus;GO:0016301,molecular_function,kinase activity;GO:0005737,cellular_component,cytoplasm;GO:0034340,biological_process,response to type I interferon;GO:0005524,molecular_function,ATP binding;GO:0004704,molecular_function,NF-kappaB-inducing kinase activity;GO:0016605,cellular_component,PML body;GO:0016310,biological_process,phosphorylation;GO:0008384,molecular_function,IkappaB kinase activity;GO:0035456,biological_process,response to interferon-beta;GO:0036435,molecular_function,K48-linked polyubiquitin modification-dependent protein binding;GO:0006468,biological_process,protein phosphorylation;GO:0031966,cellular_component,mitochondrial membrane;GO:0098586,biological_process,cellular response to virus;GO:0010884,biological_process,positive regulation of lipid storage;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0007252,biological_process,I-kappaB phosphorylation","K07211,ko05160,Hepatitis C;K07211,ko04622,RIG-I-like receptor signaling pathway;K07211,ko05164,Influenza A;K07211,ko05161,Hepatitis B;K07211,ko04623,Cytosolic DNA-sensing pathway;K07211,ko05162,Measles;K07211,ko05168,Herpes simplex infection;K07211,ko04620,Toll-like receptor signaling pathway"]
["LARP4B",12.11720124,2.705852694,2.161791512,6.588262171,{"v":1.35e-17,"d":"1.35E-17"},{"v":7.06e-16,"d":"7.06E-16"},"ENSG00000107929","H2Q1I9,La ribonucleoprotein domain family, member 4B","XP_016818020.1,-","PF05383,La domain","IPR006630,La-type HTH domain;IPR034900,LARP5, RNA recognition motif;IPR036390,Winged helix DNA-binding domain superfamily;IPR035979,RNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily","ENOG410IN3Y,-;ENOG4111REM,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0030529,,","-"]
["USP3",8.319057125,1.856928334,2.160830252,5.341405906,{"v":4.37e-13,"d":"4.37E-13"},8.62E-12,"ENSG00000140455","K7ANC2,Ubiquitinyl hydrolase 1","XP_016783826.1,ubiquitin carboxyl-terminal hydrolase 3 isoform X2","PF02148,Zn-finger in ubiquitin-hydrolases and other protein;PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR001607,Zinc finger, UBP-type;IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG1867,Ubiquitin-specific protease;ENOG410XQQ0,-","GO:0006508,biological_process,proteolysis;GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0016787,molecular_function,hydrolase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0006281,biological_process,DNA repair;GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0090543,cellular_component,Flemming body;GO:0042393,molecular_function,histone binding;GO:0046872,molecular_function,metal ion binding;GO:0016579,biological_process,protein deubiquitination;GO:0016578,biological_process,histone deubiquitination;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0008270,molecular_function,zinc ion binding;GO:0000790,cellular_component,nuclear chromatin;GO:0031647,biological_process,regulation of protein stability;GO:0000278,biological_process,mitotic cell cycle;GO:0005634,cellular_component,nucleus;GO:0008233,molecular_function,peptidase activity;GO:0005654,cellular_component,nucleoplasm","-"]
["PNRC1",22.06347607,4.928093258,2.159946782,5.372300651,4.38E-13,{"v":8.63e-12,"d":"8.63E-12"},"ENSG00000146278","G1RRK5,Proline rich nuclear receptor coactivator 1","XP_003258373.1,proline-rich nuclear receptor coactivator 1","PF15365,Proline-rich nuclear receptor coactivator motif","IPR026780,Proline-rich nuclear receptor coactivator 1/2","ENOG410YIYX,-;ENOG410IITX,-","-","-"]
["ALG1",6.86606292,1.530456483,2.159930012,4.31109198,{"v":6.18e-09,"d":"6.18E-09"},{"v":4.77e-08,"d":"4.77E-08"},"ENSG00000033011","H2QAJ3,ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase","XP_510796.2,chitobiosyldiphosphodolichol beta-mannosyltransferase","PF00534,lycosyl transferases group 1","IPR026051,Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like;IPR001296,Glycosyl transferase, family 1","KOG2941,Beta-1,4-mannosyltransferase;COG0438,Glycosyltransferase","GO:0097502,biological_process,mannosylation;GO:0006486,biological_process,protein glycosylation;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0005783,cellular_component,endoplasmic reticulum;GO:0000030,molecular_function,mannosyltransferase activity","K03842,ko00510,N-Glycan biosynthesis;K03842,ko00513,Various types of N-glycan biosynthesis"]
["NCKIPSD",6.43654722,1.432512876,2.159917493,3.851557187,{"v":1.69e-07,"d":"1.69E-07"},{"v":9.42e-07,"d":"9.42E-07"},"ENSG00000213672","K7AP56,NCK interacting protein with SH3 domain","XP_016796540.1,NCK-interacting protein with SH3 domain isoform X1","PF09431,Protein of unknown function (DUF2013);PF00018,SH3 domain","IPR035514,SPIN90, SH3 domain;IPR001452,SH3 domain;IPR036028,SH3-like domain superfamily;IPR018556,Domain of unknown function DUF2013","KOG4035,Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover;ENOG410Y8WT,-","GO:0008180,cellular_component,COP9 signalosome;GO:0010976,biological_process,positive regulation of neuron projection development","-"]
["FOXO6",5.545357855,1.229762721,2.159888473,3.168772585,{"v":2.69E-5,"d":"2.69E-05"},{"v":9.3e-05,"d":"9.30E-05"},"ENSG00000204060","G3S778,Forkhead box O6","-","PF00250,orkhead domain","IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR032067,FOXO protein, transactivation domain","-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["DANCR",5.819592182,1.290578121,2.159888473,3.168772585,{"v":2.69E-5,"d":"2.69E-05"},{"v":9.3e-05,"d":"9.30E-05"},"-","-","-","-","-","-","-","-"]
["RP11-155O18.6",11.53898404,2.514041778,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000272100","A0A1S3FMF5,coiled-coil and C2 domain-containing protein 1B","XP_012877746.1,coiled-coil and C2 domain-containing protein 1B","-","IPR006608,Domain of unknown function DM14;IPR000008,C2 domain;IPR037772,Freud, C2 domain;IPR035892,C2 domain superfamily","-","-","-"]
["RGL1",0.850469889,0.185295068,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000143344","Q7Z3U6,Uncharacterized protein DKFZp686C2469","-","PF00618,RasGEF N-terminal motif;PF00788,Ras association (RalGDS/AF-6) domain;PF00617,RasGEF domain","IPR000651,Ras-like guanine nucleotide exchange factor, N-terminal;IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR030748,Ral guanine nucleotide dissociation stimulator-like 1;IPR000159,Ras-associating (RA) domain;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily;IPR029071,Ubiquitin-like domain superfamily;IPR019804,Ras guanine-nucleotide exchange factor, conserved site","KOG3629,Guanine-nucleotide releasing factor;ENOG410ZUT5,-","GO:0008321,molecular_function,Ral guanyl-nucleotide exchange factor activity;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0065009,biological_process,regulation of molecular function;GO:0005622,cellular_component,intracellular;GO:0007165,biological_process,signal transduction","-"]
["HYLS1",1.504415725,0.327772703,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000198331","A0A024R3K0,Hydrolethalus syndrome 1, isoform CRA_a","XP_006718840.1,-;XP_011540961.1,-;XP_005271487.1,-;NP_659451.1,hydrolethalus syndrome protein 1;XP_016872809.1,-;XP_016872810.1,-;NP_001128265.1,-","PF15311,Hydrolethalus syndrome protein 1 C-terminus","IPR026227,Hydrolethalus syndrome protein 1;IPR027918,Hydrolethalus syndrome protein 1, C-terminal domain","ENOG410J0N2,-;ENOG4111UPE,-","GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane","-"]
["ZFHX2",0.445472231,0.097056708,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000136367","G3QQN8,Zinc finger homeobox 2","XP_018865175.1,zinc finger homeobox protein 2 isoform X1","PF12874,Zinc-finger of C2H2 type;PF00046,Homeobox domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR017970,Homeobox, conserved site;IPR003604,Matrin/U1-C-like, C2H2-type zinc finger;IPR027028,Zinc finger homeobox protein 2;IPR009057,Homeobox-like domain superfamily;IPR001356,Homeobox domain","-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0030534,biological_process,adult behavior","-"]
["RP11-264B17.2",4.131632564,0.9001743,2.159747295,1.795985371,0.010399363,0.019654368,"-","-","-","-","-","-","-","-"]
["NKD1",0.258923544,0.056412645,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000140807","G3QYL6,Naked cuticle homolog 1","XP_004057680.1,protein naked cuticle homolog 1","-","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR011992,EF-hand domain pair","-","GO:0045732,biological_process,positive regulation of protein catabolic process;GO:2000096,biological_process,positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:1901231,biological_process,positive regulation of non-canonical Wnt signaling pathway via JNK cascade;GO:0030165,molecular_function,PDZ domain binding;GO:0005509,molecular_function,calcium ion binding;GO:0030178,biological_process,negative regulation of Wnt signaling pathway;GO:0000159,cellular_component,protein phosphatase type 2A complex;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:1901233,biological_process,negative regulation of convergent extension involved in axis elongation","K03213,ko04310,Wnt signaling pathway"]
["CTB-96E2.7",4.024748225,0.876887007,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000265618","Q8N329,C3orf64 protein","-","-","-","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CRHR1-IT1",0.291984388,0.063615735,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000204650","G7PIS2,Uncharacterized protein","-","-","-","-","-","-"]
["RTN4R",1.351225744,0.294396626,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000040608","H7C215,Reticulon-4 receptor","-","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR000483,Cysteine-rich flanking region, C-terminal;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","-","-"]
["2020-09-03",0.831351163,0.181129599,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000100167","H2QLT3,Uncharacterized protein","XP_515166.3,-","PF00735,Septin","IPR030379,Septin-type guanine nucleotide-binding (G) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR008114,Septin 3;IPR016491,Septin","KOG1547,Septin CDC10 and related P-loop GTPases;COG5019,Septin family protein","GO:0005525,molecular_function,GTP binding;GO:0042802,molecular_function,identical protein binding;GO:0007049,biological_process,cell cycle;GO:0000166,molecular_function,nucleotide binding","-"]
["RAB6B",0.751331018,0.16369531,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000154917","I3MMB4,RAB6B, member RAS oncogene family","-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410XPBI,-;KOG0094,GTPase Rab6/YPT6/Ryh1, small G protein superfamily","GO:0005525,molecular_function,GTP binding;GO:0031489,molecular_function,myosin V binding;GO:0005794,cellular_component,Golgi apparatus;GO:0003924,molecular_function,GTPase activity","-"]
["FAM149A",0.86464982,0.188384503,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000109794","G1RL73,Family with sequence similarity 149 member A","-","PF12516,Protein of unknown function (DUF3719)","IPR022194,Protein of unknown function DUF3719","ENOG410ZYXN,-;ENOG410IE96,-","-","-"]
["RWDD2A",1.205059498,0.262550837,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000013392","G3S1N9,Uncharacterized protein","XP_018885466.1,-;XP_004044389.1,-;XP_004044388.1,-;XP_018885073.1,-;XP_018885465.1,-;XP_018885072.1,-","PF06544,Protein of unknown function (DUF1115);PF05773,RWD domain","IPR010541,Domain of unknown function DUF1115;IPR006575,RWD domain;IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR017359,Uncharacterised conserved protein UCP038021, RWD","-","-","-"]
["TTLL11",1.276306297,0.278073645,2.159747295,1.795985371,0.010399363,0.019654368,"ENSG00000175764","G3QE61,Tubulin tyrosine ligase like 11","-","PF03133,Tubulin-tyrosine ligase family","IPR013815,ATP-grasp fold, subdomain 1;IPR004344,Tubulin-tyrosine ligase/Tubulin polyglutamylase","-","GO:0051013,biological_process,microtubule severing;GO:0018095,biological_process,protein polyglutamylation;GO:0005524,molecular_function,ATP binding;GO:0006464,biological_process,cellular protein modification process","-"]
["EPC2",16.80343199,3.756800517,2.159342772,5.869049716,3.91E-15,{"v":1.23e-13,"d":"1.23E-13"},"ENSG00000135999","G7N818,Enhancer of polycomb homolog","XP_014965554.1,-","PF06752,nhancer of Polycomb C-terminus;PF10513,nhancer of polycomb-like","IPR019542,Enhancer of polycomb-like, N-terminal;IPR009607,Enhancer of polycomb, C-terminal;IPR024943,Enhancer of polycomb protein","KOG2261,Polycomb enhancer protein, EPC;ENOG410XSSX,-","GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0035267,cellular_component,NuA4 histone acetyltransferase complex;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0032777,cellular_component,Piccolo NuA4 histone acetyltransferase complex;GO:0005634,cellular_component,nucleus","-"]
["PRR12",16.10296488,3.603235403,2.15845456,6.148946992,{"v":4.66e-16,"d":"4.66E-16"},{"v":1.8e-14,"d":"1.80E-14"},"ENSG00000126464","A0A0D9S3V9,Proline rich 12","XP_007995765.1,proline-rich protein 12","PF13926,omain of unknown function (DUF4211)","IPR025451,Domain of unknown function DUF4211","-","-","-"]
["TRIM32",13.56915116,3.033920788,2.157719407,5.018032496,1.41E-11,{"v":1.98e-10,"d":"1.98E-10"},"ENSG00000119401","A0A024R843,Tripartite motif-containing 32, isoform CRA_a","XP_005251870.1,-;XP_011516700.1,-;NP_036342.2,-;NP_001093149.1,E3 ubiquitin-protein ligase TRIM32;XP_016869975.1,-","PF01436,NHL repeat;PF13445,RING-type zinc-finger","IPR001258,NHL repeat;IPR017907,Zinc finger, RING-type, conserved site;IPR011042,Six-bladed beta-propeller, TolB-like;IPR000315,B-box-type zinc finger;IPR001841,Zinc finger, RING-type;IPR013017,NHL repeat, subgroup;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR027370,RING-type zinc-finger, LisH dimerisation motif","ENOG410XRCH,-;ENOG410ITFD,-","GO:0000209,biological_process,protein polyubiquitination;GO:0009411,biological_process,response to UV;GO:0031369,molecular_function,translation initiation factor binding;GO:1903883,biological_process,positive regulation of interleukin-17-mediated signaling pathway;GO:1903886,biological_process,positive regulation of chemokine (C-C motif) ligand 20 production;GO:0005634,cellular_component,nucleus;GO:0003723,molecular_function,RNA binding;GO:0045732,biological_process,positive regulation of protein catabolic process;GO:0016567,biological_process,protein ubiquitination;GO:0051155,biological_process,positive regulation of striated muscle cell differentiation;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0034612,biological_process,response to tumor necrosis factor;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity;GO:0050769,biological_process,positive regulation of neurogenesis;GO:0017022,molecular_function,myosin binding;GO:0045444,biological_process,fat cell differentiation;GO:2000147,biological_process,positive regulation of cell motility;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0001894,biological_process,tissue homeostasis;GO:0008270,molecular_function,zinc ion binding;GO:1903265,biological_process,positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0046872,molecular_function,metal ion binding;GO:0046716,biological_process,muscle cell cellular homeostasis;GO:0005863,cellular_component,striated muscle myosin thick filament;GO:0005622,cellular_component,intracellular;GO:0007014,biological_process,actin ubiquitination;GO:0061564,biological_process,axon development;GO:0048147,biological_process,negative regulation of fibroblast proliferation","K10607,ko04120,Ubiquitin mediated proteolysis"]
["MYC",49.21699779,11.0276601,2.156866385,6.515382778,2.57E-17,{"v":1.27e-15,"d":"1.27E-15"},"ENSG00000136997","A0A087WUS5,Myc proto-oncogene protein","-","PF00010,Helix-loop-helix DNA-binding domain;PF02344,Myc leucine zipper domain;PF01056,Myc amino-terminal region","IPR003327,Leucine zipper, Myc;IPR012682,Transcription regulator Myc, N-terminal;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR002418,Transcription regulator Myc;IPR036638,Helix-loop-helix DNA-binding domain superfamily","ENOG41124Q3,-;ENOG410IFSM,-","GO:0001541,biological_process,ovarian follicle development;GO:0044344,biological_process,cellular response to fibroblast growth factor stimulus;GO:0046983,molecular_function,protein dimerization activity;GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0046982,molecular_function,protein heterodimerization activity;GO:0060252,biological_process,positive regulation of glial cell proliferation;GO:0010918,biological_process,positive regulation of mitochondrial membrane potential;GO:0021854,biological_process,hypothalamus development;GO:0006006,biological_process,glucose metabolic process;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:1904628,biological_process,cellular response to phorbol 13-acetate 12-myristate;GO:0006352,biological_process,DNA-templated transcription, initiation;GO:0043388,biological_process,positive regulation of DNA binding;GO:0045471,biological_process,response to ethanol;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0044330,biological_process,canonical Wnt signaling pathway involved in positive regulation of wound healing;GO:0003677,molecular_function,DNA binding;GO:0006848,biological_process,pyruvate transport;GO:0071322,biological_process,cellular response to carbohydrate stimulus;GO:0005634,cellular_component,nucleus;GO:0030728,biological_process,ovulation;GO:0071378,biological_process,cellular response to growth hormone stimulus;GO:0071966,biological_process,fungal-type cell wall polysaccharide metabolic process;GO:0006865,biological_process,amino acid transport;GO:0048146,biological_process,positive regulation of fibroblast proliferation;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0060548,biological_process,negative regulation of cell death;GO:0001701,biological_process,in utero embryonic development;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0046325,biological_process,negative regulation of glucose import;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0005739,cellular_component,mitochondrion;GO:1903841,biological_process,cellular response to arsenite(3-);GO:0045787,biological_process,positive regulation of cell cycle;GO:1903862,biological_process,positive regulation of oxidative phosphorylation;GO:1904385,biological_process,cellular response to angiotensin;GO:0032355,biological_process,response to estradiol;GO:0046722,biological_process,lactic acid secretion;GO:0071391,biological_process,cellular response to estrogen stimulus;GO:0002082,biological_process,regulation of oxidative phosphorylation;GO:0000320,biological_process,re-entry into mitotic cell cycle;GO:0071300,biological_process,cellular response to retinoic acid;GO:0035690,biological_process,cellular response to drug;GO:0043565,molecular_function,sequence-specific DNA binding;GO:1904586,biological_process,cellular response to putrescine;GO:0045821,biological_process,positive regulation of glycolytic process;GO:2001171,biological_process,positive regulation of ATP biosynthetic process;GO:0097421,biological_process,liver regeneration;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0045023,biological_process,G0 to G1 transition;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0010629,biological_process,negative regulation of gene expression;GO:0032869,biological_process,cellular response to insulin stimulus;GO:0071409,biological_process,cellular response to cycloheximide;GO:1901857,biological_process,positive regulation of cellular respiration;GO:0036120,biological_process,cellular response to platelet-derived growth factor stimulus;GO:1990859,biological_process,cellular response to endothelin;GO:0005654,cellular_component,nucleoplasm;GO:0007346,biological_process,regulation of mitotic cell cycle;GO:1990646,biological_process,cellular response to prolactin;GO:0071347,biological_process,cellular response to interleukin-1;GO:0005730,cellular_component,nucleolus;GO:0008283,biological_process,cell proliferation;GO:1990858,biological_process,cellular response to lectin;GO:0044752,biological_process,response to human chorionic gonadotropin;GO:1904620,biological_process,cellular response to dimethyl sulfoxide;GO:0003690,molecular_function,double-stranded DNA binding;GO:0009611,biological_process,response to wounding;GO:0019087,biological_process,transformation of host cell by virus;GO:0071394,biological_process,cellular response to testosterone stimulus;GO:0007007,biological_process,inner mitochondrial membrane organization;GO:0008134,molecular_function,transcription factor binding;GO:0009812,biological_process,flavonoid metabolic process;GO:0014911,biological_process,positive regulation of smooth muscle cell migration;GO:0071464,biological_process,cellular response to hydrostatic pressure;GO:0006351,biological_process,transcription, DNA-templated","-"]
["PPP1CC",15.88569173,3.558464868,2.156834308,6.091935731,6.37E-16,2.41E-14,"ENSG00000186298","A0A096NG68,Serine/threonine-protein phosphatase","-","PF00149,Calcineurin-like phosphoesterase;PF16891,Serine-threonine protein phosphatase N-terminal domain","IPR029052,Metallo-dependent phosphatase-like;IPR004843,Calcineurin-like phosphoesterase domain, ApaH type;IPR031675,Serine-threonine protein phosphatase, N-terminal;IPR006186,Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase;IPR037981,Serine/threonine-protein phosphatase PP1-gamma catalytic subunit","-","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0046872,molecular_function,metal ion binding;GO:0006470,biological_process,protein dephosphorylation;GO:0000164,cellular_component,protein phosphatase type 1 complex;GO:0004722,molecular_function,protein serine/threonine phosphatase activity","-"]
["UBE2D2",23.03817495,5.160054253,2.156470565,5.677833785,{"v":2.93e-14,"d":"2.93E-14"},{"v":7.51e-13,"d":"7.51E-13"},"ENSG00000131508","A0A218UN76,Ubiquitin-conjugating enzyme E2 D2","-","-","IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR023313,Ubiquitin-conjugating enzyme, active site;IPR000608,Ubiquitin-conjugating enzyme E2","-","GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["USPL1",2.872688587,0.639343307,2.156031716,3.304893731,{"v":1.03E-5,"d":"1.03E-05"},{"v":3.93E-5,"d":"3.93E-05"},"ENSG00000132952","A8K1B1,cDNA FLJ75211, highly similar to Homo sapiens ubiquitin specific peptidase like 1, mRNA","NP_005791.3,SUMO-specific isopeptidase USPL1 isoform 1;NP_001308461.1,SUMO-specific isopeptidase USPL1 isoform 2","PF15499,Ubiquitin-specific peptidase-like, SUMO isopeptidase;PF15509,omain of unknown function (DUF4650)","IPR033505,USPL1 peptidase;IPR028890,Ubiquitin-specific peptidase-like, SUMO isopeptidase;IPR028889,Ubiquitin specific protease domain;IPR029388,Domain of unknown function DUF4650","ENOG410YB7R,-;ENOG410IJ9P,-","GO:0030576,biological_process,Cajal body organization;GO:0006508,biological_process,proteolysis;GO:0032183,molecular_function,SUMO binding;GO:0070140,molecular_function,SUMO-specific isopeptidase activity","-"]
["RHBDF2",2.126304016,0.473228546,2.156031716,3.304893731,{"v":1.03E-5,"d":"1.03E-05"},{"v":3.93E-5,"d":"3.93E-05"},"ENSG00000129667","G3RHH8,Inactive rhomboid protein","XP_004040944.1,inactive rhomboid protein 2;XP_018883031.1,-;XP_018883029.1,-","PF12595,Rhomboid serine protease;PF01694,Rhomboid family","IPR022241,Rhomboid serine protease;IPR002610,Peptidase S54, rhomboid;IPR035952,Rhomboid-like superfamily;IPR022764,Peptidase S54, rhomboid domain","-","GO:0006508,biological_process,proteolysis;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PALLD",1.455658395,0.323970185,2.156031716,3.304893731,{"v":1.03E-5,"d":"1.03E-05"},{"v":3.93E-5,"d":"3.93E-05"},"ENSG00000129116","B2RTX2,Palladin, cytoskeletal associated protein","NP_057165.3,palladin isoform 2","PF07679,Immunoglobulin I-set domain","IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR033017,Palladin, C-terminal immunoglobulin-like domain;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","ENOG41103YT,-;ENOG410IGH0,-","GO:0015629,cellular_component,actin cytoskeleton;GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane;GO:0030036,biological_process,actin cytoskeleton organization;GO:0016477,biological_process,cell migration","-"]
["KLHL7",2.08357331,0.463718433,2.156031716,3.304893731,{"v":1.03E-5,"d":"1.03E-05"},{"v":3.93E-5,"d":"3.93E-05"},"ENSG00000122550","G1T839,Kelch like family member 7","XP_002713758.1,-","PF01344,Kelch motif;PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch","IPR011705,BTB/Kelch-associated;IPR011333,SKP1/BTB/POZ domain superfamily;IPR015915,Kelch-type beta propeller;IPR017096,BTB-kelch protein;IPR030599,Kelch-like protein 7;IPR006652,Kelch repeat type 1;IPR000210,BTB/POZ domain","KOG4441,Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes;ENOG410XNX8,-","GO:0005730,cellular_component,nucleolus;GO:0042803,molecular_function,protein homodimerization activity;GO:0016567,biological_process,protein ubiquitination;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0031463,cellular_component,Cul3-RING ubiquitin ligase complex;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["EP400",7.731260544,1.73422513,2.155225789,6.485550594,{"v":3.79e-17,"d":"3.79E-17"},{"v":1.81e-15,"d":"1.81E-15"},"ENSG00000183495","G3QSF0,E1A binding protein p400","-","PF07529,HSA;PF00271,Helicase conserved C-terminal domain;PF00176,SNF2 family N-terminal domain;PF15790,1A-binding protein p400, N-terminal","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR014012,Helicase/SANT-associated domain;IPR031575,E1A-binding protein p400, N-terminal;IPR017877,Myb-like domain;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR001650,Helicase, C-terminal","-","GO:0005524,molecular_function,ATP binding","-"]
["ZNF142",5.02489298,1.124381281,2.155072932,4.491333599,{"v":1.03E-9,"d":"1.03E-09"},{"v":9.43e-09,"d":"9.43E-09"},"ENSG00000115568","A0A024R418,Zinc finger protein 142","-","PF00096,Zinc finger, C2H2 type;PF13909,C2H2-type zinc-finger domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["EIF3L",74.73140513,16.77978536,2.154456346,7.626941383,{"v":2.6e-20,"d":"2.60E-20"},2.24E-18,"ENSG00000100129","B0QY89,Eukaryotic translation initiation factor 3 subunit L","-","PF10255,RNA polymerase I-associated factor PAF67","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019382,Translation initiation factor 3 complex subunit L","KOG3677,RNA polymerase I-associated factor - PAF67;ENOG410XPJT,-","GO:0005737,cellular_component,cytoplasm;GO:0033290,cellular_component,eukaryotic 48S preinitiation complex;GO:0001732,biological_process,formation of cytoplasmic translation initiation complex;GO:0006413,biological_process,translational initiation;GO:0003743,molecular_function,translation initiation factor activity;GO:0005852,cellular_component,eukaryotic translation initiation factor 3 complex;GO:0016282,cellular_component,eukaryotic 43S preinitiation complex;GO:0002183,biological_process,cytoplasmic translational initiation;GO:0006412,biological_process,translation","-"]
["RP11-24N18.1",158.5750801,35.54315336,2.153855379,4.889808312,{"v":3.7e-11,"d":"3.70E-11"},{"v":4.68e-10,"d":"4.68E-10"},"-","-","-","-","-","-","-","-"]
["VAV3",2.220779794,0.495708691,2.152861843,3.429078356,{"v":4.13e-06,"d":"4.13E-06"},{"v":1.71e-05,"d":"1.71E-05"},"ENSG00000134215","F7BD31,Vav guanine nucleotide exchange factor 3","XP_002801727.1,guanine nucleotide exchange factor VAV3 isoform X1","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF00621,RhoGEF domain;PF07653,Variant SH3 domain;PF00017,SH2 domain;PF00169,PH domain","IPR001715,Calponin homology domain;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR036860,SH2 domain superfamily;IPR036872,CH domain superfamily;IPR035881,VAV3, SH2 domain;IPR001849,Pleckstrin homology domain;IPR000980,SH2 domain;IPR037832,Vav, PH domain;IPR003096,Smooth muscle protein/calponin;IPR022613,Calmodulin-regulated spectrin-associated protein, CH domain;IPR036028,SH3-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR035899,Dbl homology (DH) domain superfamily;IPR035734,VAV3 protein, second SH3 domain;IPR001452,SH3 domain;IPR011993,PH-like domain superfamily;IPR001331,Guanine-nucleotide dissociation stimulator, CDC24, conserved site","KOG2996,Rho guanine nucleotide exchange factor VAV3;ENOG410XPH6,-","GO:0006906,biological_process,vesicle fusion;GO:0005886,cellular_component,plasma membrane;GO:0030676,molecular_function,Rac guanyl-nucleotide exchange factor activity;GO:0008361,biological_process,regulation of cell size;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0043087,biological_process,regulation of GTPase activity;GO:0030593,biological_process,neutrophil chemotaxis;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0042493,biological_process,response to drug;GO:0050853,biological_process,B cell receptor signaling pathway;GO:0030032,biological_process,lamellipodium assembly;GO:0005154,molecular_function,epidermal growth factor receptor binding;GO:0045785,biological_process,positive regulation of cell adhesion;GO:0043552,biological_process,positive regulation of phosphatidylinositol 3-kinase activity;GO:0030031,biological_process,cell projection assembly;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0046872,molecular_function,metal ion binding;GO:0030890,biological_process,positive regulation of B cell proliferation;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0016477,biological_process,cell migration","-"]
["TCTN2",3.162414782,0.705894613,2.152861843,3.429078356,{"v":4.13e-06,"d":"4.13E-06"},{"v":1.71e-05,"d":"1.71E-05"},"ENSG00000168778","K7BW15,Tectonic family member 2","XP_016780052.1,tectonic-2 isoform X1","PF07773,Protein of unknown function (DUF1619)","IPR011677,Domain of unknown function DUF1619","ENOG410IJPP,-;ENOG4111MZ0,-","-","-"]
["TENM3",1.347516472,0.300784269,2.152861843,3.429078356,{"v":4.13e-06,"d":"4.13E-06"},{"v":1.71e-05,"d":"1.71E-05"},"ENSG00000218336","A0A140VJW8,Testicular tissue protein Li 195","XP_016863882.1,-;NP_001073946.1,teneurin-3","PF06484,Teneurin Intracellular Region;PF15636,HH signature containing HNH/Endo VII superfamily nuclease toxin","IPR008969,Carboxypeptidase-like, regulatory domain superfamily;IPR027689,Teneurin-2/3;IPR022385,Rhs repeat-associated core;IPR028916,Tox-GHH domain;IPR036322,WD40-repeat-containing domain superfamily;IPR011042,Six-bladed beta-propeller, TolB-like;IPR006530,YD repeat;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR009471,Teneurin intracellular, N-terminal","-","GO:0005887,cellular_component,integral component of plasma membrane;GO:0097264,biological_process,self proteolysis;GO:0016021,cellular_component,integral component of membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane","-"]
["CRTC2",13.34562832,2.993602904,2.152857058,4.931943224,2.35E-11,3.13E-10,"ENSG00000160741","G3S1G0,CREB regulated transcription coactivator 2","XP_004026813.1,CREB-regulated transcription coactivator 2 isoform X2","PF12886,Transducer of regulated CREB activity, C terminus;PF12885,Transducer of regulated CREB activity middle domain;PF12884,Transducer of regulated CREB activity, N terminus","IPR024785,Transducer of regulated CREB activity, C-terminal;IPR024784,Transducer of regulated CREB activity, middle domain;IPR024786,CREB-regulated transcription coactivator;IPR024783,Transducer of regulated CREB activity, N-terminal","-","GO:0005737,cellular_component,cytoplasm;GO:0051289,biological_process,protein homotetramerization;GO:0005634,cellular_component,nucleus;GO:0008140,molecular_function,cAMP response element binding protein binding;GO:0032793,biological_process,positive regulation of CREB transcription factor activity","K16333,ko04931,Insulin resistance;K16333,ko04152,AMPK signaling pathway;K16333,ko05166,HTLV-I infection;K16333,ko04922,Glucagon signaling pathway;K16333,ko04151,PI3K-Akt signaling pathway"]
["SSBP3",5.31525483,1.191047533,2.151739674,4.167244962,{"v":1.95e-08,"d":"1.95E-08"},{"v":1.35E-7,"d":"1.35E-07"},"ENSG00000157216","H9Z778,Single-stranded DNA-binding protein 3 isoform a","NP_001248013.1,-","-","IPR008116,Sequence-specific single-strand DNA-binding protein;IPR006594,LIS1 homology motif","-","GO:0003697,molecular_function,single-stranded DNA binding;GO:0003677,molecular_function,DNA binding","-"]
["ZNF761",5.893686253,1.320663016,2.151739674,4.167244962,{"v":1.95e-08,"d":"1.95E-08"},{"v":1.35E-7,"d":"1.35E-07"},"ENSG00000160336","A0A087WXT7,Zinc finger protein 761","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["DAB2IP",10.22366468,2.299255859,2.150684676,5.746939168,{"v":1.52e-14,"d":"1.52E-14"},{"v":4.17e-13,"d":"4.17E-13"},"ENSG00000136848","K6ZV89,DAB2 interacting protein","XP_016817063.1,-","PF12004,omain of unknown function (DUF3498);PF00616,TPase-activator protein for Ras-like GTPase;PF00168,C2 domain","IPR001936,Ras GTPase-activating domain;IPR030403,Disabled homologue 2-interacting protein;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR021887,Domain of unknown function DUF3498;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR008936,Rho GTPase activation protein;IPR023152,Ras GTPase-activating protein, conserved site","KOG3508,GTPase-activating protein;ENOG410XPU1,-","GO:0016525,biological_process,negative regulation of angiogenesis;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0043087,biological_process,regulation of GTPase activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0030948,biological_process,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0005096,molecular_function,GTPase activator activity;GO:0038026,biological_process,reelin-mediated signaling pathway;GO:0007165,biological_process,signal transduction","-"]
["KMO",0.998402898,0.220426132,2.150268515,2.131667455,0.002813195,6.116285E-3,"ENSG00000117009","A0A024R3S9,Kynurenine 3-monooxygenase","-","PF13450,NAD(P)-binding Rossmann-like domain;PF01494,AD binding domain","IPR027545,Kynurenine 3-monooxygenase;IPR036188,FAD/NAD(P)-binding domain superfamily;IPR002938,FAD-binding domain","COG0654,2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases;KOG2614,Kynurenine 3-monooxygenase and related flavoprotein monooxygenases","GO:0019363,biological_process,pyridine nucleotide biosynthetic process;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0004502,molecular_function,kynurenine 3-monooxygenase activity;GO:0043420,biological_process,anthranilate metabolic process;GO:0009435,biological_process,NAD biosynthetic process;GO:0006569,biological_process,tryptophan catabolic process;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0004497,molecular_function,monooxygenase activity;GO:0031966,cellular_component,mitochondrial membrane;GO:0016491,molecular_function,oxidoreductase activity;GO:0071949,molecular_function,FAD binding;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0019805,biological_process,quinolinate biosynthetic process;GO:0034354,biological_process,'de novo' NAD biosynthetic process from tryptophan;GO:0016021,cellular_component,integral component of membrane;GO:0005739,cellular_component,mitochondrion","-"]
["RORA",0.348386363,0.076916302,2.150268515,2.131667455,0.002813195,6.116285E-3,"ENSG00000069667","G3QE47,RAR related orphan receptor A","-","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR003079,Nuclear receptor ROR;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR013088,Zinc finger, NHR/GATA-type","-","GO:2000188,-,-;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0008589,biological_process,regulation of smoothened signaling pathway;GO:0001046,molecular_function,core promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0043401,biological_process,steroid hormone mediated signaling pathway;GO:0008013,molecular_function,beta-catenin binding;GO:0032922,biological_process,circadian regulation of gene expression;GO:0071347,biological_process,cellular response to interleukin-1;GO:0072539,biological_process,T-helper 17 cell differentiation;GO:0019218,biological_process,regulation of steroid metabolic process;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045599,biological_process,negative regulation of fat cell differentiation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0001222,molecular_function,transcription corepressor binding;GO:0010575,biological_process,positive regulation of vascular endothelial growth factor production;GO:0006805,biological_process,xenobiotic metabolic process;GO:0021930,biological_process,cerebellar granule cell precursor proliferation;GO:0050728,biological_process,negative regulation of inflammatory response;GO:0036315,biological_process,cellular response to sterol;GO:0046068,biological_process,cGMP metabolic process;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0043124,biological_process,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0006809,biological_process,nitric oxide biosynthetic process;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0042692,biological_process,muscle cell differentiation;GO:0008142,molecular_function,oxysterol binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0098531,molecular_function,transcription factor activity, direct ligand regulated sequence-specific DNA binding;GO:0001223,molecular_function,transcription coactivator binding;GO:0001525,biological_process,angiogenesis;GO:0021702,biological_process,cerebellar Purkinje cell differentiation;GO:0071456,biological_process,cellular response to hypoxia;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0008270,molecular_function,zinc ion binding;GO:0070328,biological_process,triglyceride homeostasis;GO:0004879,molecular_function,nuclear receptor activity;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:0043030,biological_process,regulation of macrophage activation;GO:0046872,molecular_function,metal ion binding;GO:0042753,biological_process,positive regulation of circadian rhythm;GO:0010906,biological_process,regulation of glucose metabolic process;GO:0042752,biological_process,regulation of circadian rhythm;GO:0060850,biological_process,regulation of transcription involved in cell fate commitment;GO:0006351,biological_process,transcription, DNA-templated","-"]
["TNFAIP3",1.175312539,0.259484019,2.150268515,2.131667455,0.002813195,6.116285E-3,"ENSG00000118503","D3TTZ4,Tumor necrosis factor alpha-induced protein 3","-","PF02338,OTU-like cysteine protease;PF01754,A20-like zinc finger","IPR002653,Zinc finger, A20-type;IPR003323,OTU domain;IPR033478,A20 peptidase","ENOG410IQZK,-;ENOG41117NJ,-","GO:0003677,molecular_function,DNA binding;GO:0016579,biological_process,protein deubiquitination;GO:0008270,molecular_function,zinc ion binding;GO:0016567,biological_process,protein ubiquitination","-"]
["DLX6",1.721224596,0.380009794,2.150268515,2.131667455,0.002813195,6.116285E-3,"ENSG00000006377","H2QUZ1,Uncharacterized protein","-","PF00046,Homeobox domain","-","-","-","-"]
["PIGO",0.823485037,0.181807987,2.150268515,2.131667455,0.002813195,6.116285E-3,"ENSG00000165282","K7A107,Phosphatidylinositol glycan anchor biosynthesis, class O","XP_009454822.2,-;XP_016816274.1,-;XP_001165498.2,-","PF01663,Type I phosphodiesterase / nucleotide pyrophosphatase","IPR002591,Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase;IPR037675,GPI ethanolamine phosphate transferase 3, N-terminal;IPR017850,Alkaline-phosphatase-like, core domain superfamily;IPR017849,Alkaline phosphatase-like, alpha/beta/alpha","COG1524,Uncharacterized proteins of the AP superfamily;KOG2126,Glycosylphosphatidylinositol anchor synthesis protein","GO:0006506,biological_process,GPI anchor biosynthetic process;GO:0051377,molecular_function,mannose-ethanolamine phosphotransferase activity;GO:0003824,molecular_function,catalytic activity;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K05288,ko00563,Glycosylphosphatidylinositol(GPI)-anchor biosynthesis"]
["STS",0.910367065,0.200989692,2.150268515,2.131667455,0.002813195,6.116285E-3,"ENSG00000101846","H2QY96,Steroid sulfatase","-","PF14707,C-terminal region of aryl-sulfatase;PF00884,Sulfatase","IPR024607,Sulfatase, conserved site;IPR000917,Sulfatase, N-terminal;IPR017850,Alkaline-phosphatase-like, core domain superfamily;IPR017849,Alkaline phosphatase-like, alpha/beta/alpha","KOG3867,Sulfatase;COG3119,Arylsulfatase A and related enzymes","GO:0008484,molecular_function,sulfuric ester hydrolase activity;GO:0003824,molecular_function,catalytic activity;GO:0016021,cellular_component,integral component of membrane;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane","-"]
["GPRASP2",1.493460033,0.329724221,2.150268515,2.131667455,0.002813195,6.116285E-3,"ENSG00000158301","B3KW05,cDNA FLJ41838 fis, clone NT2RI3001515, highly similar to G-protein coupled receptor-associated sorting protein 2","NP_001004051.1,-;NP_612446.1,G-protein coupled receptor-associated sorting protein 2;NP_001171804.1,-;NP_001171805.1,-;NP_001171803.1,-","PF04826,Armadillo-like","IPR016024,Armadillo-type fold;IPR006911,Armadillo repeat-containing domain","ENOG410IVHR,-;ENOG410XUVQ,-","-","-"]
["TAF5",5.377004514,1.203170545,2.150210354,3.5432642,{"v":1.71e-06,"d":"1.71E-06"},{"v":7.71e-06,"d":"7.71E-06"},"ENSG00000148835","H2Q2I6,Uncharacterized protein","XP_001135279.1,transcription initiation factor TFIID subunit 5","PF00400,WD domain, G-beta repeat;PF04494,WD40 associated region in TFIID subunit, NTD2 domain","IPR019775,WD40 repeat, conserved site;IPR007582,TFIID subunit TAF5, NTD2 domain;IPR017986,WD40-repeat-containing domain;IPR006594,LIS1 homology motif;IPR036322,WD40-repeat-containing domain superfamily;IPR037264,TFIID subunit TAF5, NTD2 domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat","KOG0263,Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA);ENOG410XPM5,-","-","K03130,ko05168,Herpes simplex infection;K03130,ko03022,Basal transcription factors"]
["KCNC3",2.799434563,0.626407733,2.150210354,3.5432642,{"v":1.71e-06,"d":"1.71E-06"},{"v":7.71e-06,"d":"7.71E-06"},"ENSG00000131398","F6ZNJ8,Potassium voltage-gated channel subfamily C member 3","-","PF00520,Ion transport protein","IPR003131,Potassium channel tetramerisation-type BTB domain;IPR003974,Potassium channel, voltage dependent, Kv3;IPR011333,SKP1/BTB/POZ domain superfamily;IPR003968,Potassium channel, voltage dependent, Kv;IPR027359,Voltage-dependent channel domain superfamily;IPR005821,Ion transport domain;IPR005404,Potassium channel, voltage dependent, Kv3.3;IPR000210,BTB/POZ domain;IPR028325,Voltage-gated potassium channel","KOG3713,Voltage-gated K+ channel KCNB/KCNC;COG1226,Kef-type K+ transport systems, predicted NAD-binding component","GO:0005216,molecular_function,ion channel activity;GO:0051262,biological_process,protein tetramerization;GO:0005267,molecular_function,potassium channel activity;GO:0055085,biological_process,transmembrane transport;GO:0016020,cellular_component,membrane;GO:0005249,molecular_function,voltage-gated potassium channel activity;GO:0051260,biological_process,protein homooligomerization;GO:0006811,biological_process,ion transport;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0005886,cellular_component,plasma membrane;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0008076,cellular_component,voltage-gated potassium channel complex;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0006813,biological_process,potassium ion transport;GO:0016021,cellular_component,integral component of membrane","-"]
["ZNF83",2.188845385,0.489780934,2.150210354,3.5432642,{"v":1.71e-06,"d":"1.71E-06"},{"v":7.71e-06,"d":"7.71E-06"},"ENSG00000167766","A0A024R4L3,Zinc finger protein 83","NP_001099019.1,-;NP_001334947.1,-;NP_001264878.1,-;NP_001264874.1,-;NP_001264875.1,-;NP_060770.3,zinc finger protein 83;NP_001099021.1,-;NP_001334945.1,-;NP_001334948.1,-;NP_001099022.1,-;NP_001264876.1,-;NP_001264881.1,-;NP_001334944.1,-;NP_001334946.1,-;NP_001264880.1,-;NP_001264877.1,-;NP_001099020.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["FAM111B",7.560858884,1.696419597,2.150198478,4.236353894,{"v":7.72e-09,"d":"7.72E-09"},{"v":5.83e-08,"d":"5.83E-08"},"ENSG00000189057","H2Q3Q6,Family with sequence similarity 111 member B","XP_003318041.1,protein FAM111B isoform X1","PF13365,Trypsin-like peptidase domain","IPR009003,Peptidase S1, PA clan","ENOG4112AWX,-;ENOG410IHAZ,-","-","-"]
["SSH2",7.043947838,1.585300615,2.149704504,5.793307982,1.23E-14,{"v":3.45e-13,"d":"3.45E-13"},"ENSG00000141298","F5H527,Protein phosphatase Slingshot homolog 2","NP_001269058.1,protein phosphatase Slingshot homolog 2 isoform 1;XP_005258115.1,-","PF08766,K C terminal domain;PF00782,ual specificity phosphatase, catalytic domain","IPR029021,Protein-tyrosine phosphatase-like;IPR016130,Protein-tyrosine phosphatase, active site;IPR000340,Dual specificity phosphatase, catalytic domain;IPR020422,Dual specificity protein phosphatase domain;IPR000387,Tyrosine specific protein phosphatases domain;IPR024950,Dual specificity phosphatase;IPR014876,DEK, C-terminal","COG2453,Predicted protein-tyrosine phosphatase;KOG1716,Dual specificity phosphatase","GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity;GO:0030335,biological_process,positive regulation of cell migration","-"]
["BROX",20.45590408,4.605711075,2.149345459,5.987983117,{"v":1.74e-15,"d":"1.74E-15"},{"v":5.98e-14,"d":"5.98E-14"},"ENSG00000162819","G2HJQ0,BRO1 domain and CAAX motif containing","XP_016777532.1,-;XP_009439630.1,-;XP_009439631.1,-;XP_009439634.1,-;XP_016777749.1,-;NP_001233322.1,BRO1 domain-containing protein BROX;XP_016777660.1,-;XP_016777800.1,-","PF03097,BRO1-like domain","IPR004328,BRO1 domain;IPR038499,BRO1 domain superfamily","ENOG410ZHPX,-;ENOG410IEDQ,-","-","-"]
["CCNK",22.6482669,5.102301821,2.149263706,6.847294716,3.18E-18,{"v":1.89e-16,"d":"1.89E-16"},"ENSG00000090061","K7ETF7,Cyclin K","XP_009247750.1,-;XP_009247751.1,-","PF02984,Cyclin, C-terminal domain;PF00134,Cyclin, N-terminal domain","IPR004367,Cyclin, C-terminal domain;IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","COG5333,Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit;KOG0834,CDK9 kinase-activating protein cyclin T","GO:0004693,molecular_function,cyclin-dependent protein serine/threonine kinase activity;GO:0071157,biological_process,negative regulation of cell cycle arrest;GO:2001165,biological_process,positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues;GO:0002945,cellular_component,cyclin K-CDK13 complex;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0044828,biological_process,negative regulation by host of viral genome replication;GO:0019901,molecular_function,protein kinase binding;GO:0008353,molecular_function,RNA polymerase II carboxy-terminal domain kinase activity;GO:0002944,cellular_component,cyclin K-CDK12 complex;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["XPO6",11.12516746,2.504433975,2.149098425,5.620529333,{"v":4.34e-14,"d":"4.34E-14"},{"v":1.07e-12,"d":"1.07E-12"},"ENSG00000169180","H2QAT9,Exportin 6","XP_001138416.1,exportin-6 isoform X1","PF08389,xportin 1-like protein;PF03810,Importin-beta N-terminal domain","IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR001494,Importin-beta, N-terminal domain;IPR013598,Exportin-1/Importin-beta-like","COG5101,Importin beta-related nuclear transport receptor;KOG2020,Nuclear transport receptor CRM1/MSN5 (importin beta superfamily)","GO:0005730,cellular_component,nucleolus;GO:0006611,biological_process,protein export from nucleus;GO:0008536,molecular_function,Ran GTPase binding;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0008565,molecular_function,protein transporter activity;GO:0006886,biological_process,intracellular protein transport","-"]
["MOV10",4.706154362,1.057141242,2.148801911,4.302276209,{"v":7.99e-09,"d":"7.99E-09"},{"v":6.01e-08,"d":"6.01E-08"},"ENSG00000155363","G3QJU3,Mov10 RISC complex RNA helicase","XP_018874705.1,-;XP_018874659.1,-;XP_004026406.1,-","PF13087,AAA domain;PF13604,AAA domain","IPR026122,Putative helicase MOV-10;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","-","-"]
["SOCS7",3.553225698,0.798159418,2.148801911,4.302276209,{"v":7.99e-09,"d":"7.99E-09"},{"v":6.01e-08,"d":"6.01E-08"},"ENSG00000274211","A0A0D9S3I0,Suppressor of cytokine signaling 7","-","PF07525,SOCS box;PF00017,SH2 domain","IPR037346,SOCS7, SOCS box domain;IPR001496,SOCS box domain;IPR036860,SH2 domain superfamily;IPR036036,SOCS box-like domain superfamily;IPR000980,SH2 domain;IPR028423,Suppressor of cytokine signalling 7;IPR035866,SOCS7, SH2 domain","-","GO:0035556,biological_process,intracellular signal transduction;GO:0008286,biological_process,insulin receptor signaling pathway;GO:0016567,biological_process,protein ubiquitination;GO:0021799,biological_process,cerebral cortex radially oriented cell migration;GO:0021942,biological_process,radial glia guided migration of Purkinje cell;GO:0021819,biological_process,layer formation in cerebral cortex;GO:0005829,cellular_component,cytosol;GO:0045444,biological_process,fat cell differentiation","-"]
["ORC4",3.595863109,0.808591788,2.147530526,4.365294263,{"v":4.3e-09,"d":"4.30E-09"},{"v":3.43e-08,"d":"3.43E-08"},"ENSG00000115947","G3S8X6,Origin recognition complex subunit 4","XP_004032673.1,origin recognition complex subunit 4 isoform X1;XP_004032674.1,-","PF14629,Origin recognition complex (ORC) subunit 4 C-terminus;PF13191,AAA ATPase domain","IPR032705,Origin recognition complex subunit 4, C-terminal;IPR016527,Origin recognition complex subunit 4;IPR003593,AAA+ ATPase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0003677,molecular_function,DNA binding;GO:0005664,cellular_component,nuclear origin of replication recognition complex;GO:0006270,biological_process,DNA replication initiation;GO:0006260,biological_process,DNA replication;GO:0005730,cellular_component,nucleolus;GO:0000784,cellular_component,nuclear chromosome, telomeric region;GO:0000808,cellular_component,origin recognition complex;GO:0003688,molecular_function,DNA replication origin binding;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus","K02606,ko04113,Meiosis - yeast;K02606,ko04110,Cell cycle;K02606,ko04111,Cell cycle - yeast"]
["MLLT3",3.943550205,0.886775223,2.147530526,4.365294263,{"v":4.3e-09,"d":"4.30E-09"},{"v":3.43e-08,"d":"3.43E-08"},"ENSG00000171843","F7B5N5,MLLT3, super elongation complex subunit","XP_003732036.1,protein AF-9 isoform X1","PF03366,YEATS family","IPR038704,YEATS superfamily;IPR005033,YEATS","KOG3149,Transcription initiation factor IIF, auxiliary subunit;COG5033,Transcription initiation factor IIF, auxiliary subunit","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus","K15187,ko05202,Transcriptional misregulation in cancer"]
["TXNDC5",24.84481575,5.601722904,2.147438568,6.084343323,{"v":9.13e-16,"d":"9.13E-16"},{"v":3.33e-14,"d":"3.33E-14"},"ENSG00000239264","K7AS92,Thioredoxin domain containing 5","-","PF00085,Thioredoxin","-","-","-","-"]
["PIKFYVE",3.091015554,0.695740328,2.146368213,4.425654369,{"v":2.35e-09,"d":"2.35E-09"},{"v":1.99E-8,"d":"1.99E-08"},"ENSG00000115020","V9HWG4,Epididymis luminal protein 37","-","PF00610,omain found in Dishevelled, Egl-10, and Pleckstrin (DEP);PF01363,YVE zinc finger;PF00118,TCP-1/cpn60 chaperonin family;PF01504,Phosphatidylinositol-4-phosphate 5-Kinase","IPR017455,Zinc finger, FYVE-related;IPR036390,Winged helix DNA-binding domain superfamily;IPR011011,Zinc finger, FYVE/PHD-type;IPR000306,FYVE zinc finger;IPR027409,GroEL-like apical domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR027410,TCP-1-like chaperonin intermediate domain superfamily;IPR037378,PIKfyve, DEP domain;IPR000591,DEP domain;IPR027484,Phosphatidylinositol-4-phosphate 5-kinase, N-terminal;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR002498,Phosphatidylinositol-4-phosphate 5-kinase, core;IPR002423,Chaperonin Cpn60/TCP-1 family","COG0459,Chaperonin GroEL (HSP60 family);KOG0230,Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins;ENOG410IMP3,-;COG5253,Phosphatidylinositol-4-phosphate 5-kinase","GO:0016301,molecular_function,kinase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0046488,biological_process,phosphatidylinositol metabolic process;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0005524,molecular_function,ATP binding;GO:0016307,molecular_function,phosphatidylinositol phosphate kinase activity;GO:0000285,molecular_function,1-phosphatidylinositol-3-phosphate 5-kinase activity;GO:0005622,cellular_component,intracellular;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0046854,biological_process,phosphatidylinositol phosphorylation","-"]
["MUT",8.930883031,2.010205185,2.146368213,4.425654369,{"v":2.35e-09,"d":"2.35E-09"},{"v":1.99E-8,"d":"1.99E-08"},"ENSG00000146085","A0A024RD82,Methylmalonyl CoA mutase isoform 1","NP_000246.2,methylmalonyl-CoA mutase, mitochondrial precursor;XP_005249200.1,-","PF01642,Methylmalonyl-CoA mutase;PF02310,B12 binding domain","IPR006158,Cobalamin (vitamin B12)-binding domain;IPR006099,Methylmalonyl-CoA mutase, alpha/beta chain, catalytic;IPR036724,Cobalamin-binding domain superfamily;IPR006159,Methylmalonyl-CoA mutase, C-terminal;IPR016176,Cobalamin (vitamin B12)-dependent enzyme, catalytic;IPR006098,Methylmalonyl-CoA mutase, alpha chain, catalytic","ENOG410IE7I,-;COG2185,Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding);COG1884,Methylmalonyl-CoA mutase, N-terminal domain/subunit","GO:0031419,molecular_function,cobalamin binding;GO:0016866,molecular_function,intramolecular transferase activity;GO:0003824,molecular_function,catalytic activity;GO:0046872,molecular_function,metal ion binding;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0009791,biological_process,post-embryonic development;GO:0016853,molecular_function,isomerase activity;GO:0004494,molecular_function,methylmalonyl-CoA mutase activity","K01847,ko00640,Propanoate metabolism;K01847,ko00630,Glyoxylate and dicarboxylate metabolism;K01847,ko01200,Carbon metabolism;K01847,ko00280,Valine, leucine and isoleucine degradation;K01847,ko00720,Carbon fixation pathways in prokaryotes"]
["PUDP",6.446203439,1.448007649,2.146025361,3.747325273,{"v":5.01e-07,"d":"5.01E-07"},{"v":2.52E-6,"d":"2.52E-06"},"ENSG00000130021","G3QP56,Pseudouridine 5'-phosphatase","XP_004063801.1,pseudouridine-5'-phosphatase isoform X3","PF13419,Haloacid dehalogenase-like hydrolase","IPR006439,HAD hydrolase, subfamily IA;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR023198,Phosphoglycolate phosphatase-like, domain 2","-","GO:0016787,molecular_function,hydrolase activity;GO:0008152,biological_process,metabolic process","-"]
["ZDHHC6",9.313404844,2.09816507,2.145301514,4.483572691,{"v":1.31E-9,"d":"1.31E-09"},{"v":1.17e-08,"d":"1.17E-08"},"ENSG00000023041","H2Q2K7,Palmitoyltransferase","XP_001147499.1,-;XP_009457528.1,-;XP_009457527.1,-","PF07653,Variant SH3 domain;PF01529,HHC palmitoyltransferase","IPR001452,SH3 domain;IPR001594,Palmitoyltransferase, DHHC domain","COG5273,Uncharacterized protein containing DHHC-type Zn finger;KOG1314,DHHC-type Zn-finger protein","GO:0016409,molecular_function,palmitoyltransferase activity;GO:0019706,molecular_function,protein-cysteine S-palmitoyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0018345,biological_process,protein palmitoylation;GO:0016020,cellular_component,membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016021,cellular_component,integral component of membrane","-"]
["MRRF",11.03315411,2.492865627,2.14457278,6.243050608,{"v":3.13e-16,"d":"3.13E-16"},1.25E-14,"ENSG00000148187","K7C0Z1,RNA binding motif protein 18","-","-","-","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TMEM62",1.530408421,0.340606492,2.144472621,2.402311738,0.001905282,0.004324641,"ENSG00000137842","H2Q9A1,Transmembrane protein 62","XP_003314703.1,transmembrane protein 62 isoform X1","PF00149,Calcineurin-like phosphoesterase","IPR029052,Metallo-dependent phosphatase-like;IPR004843,Calcineurin-like phosphoesterase domain, ApaH type","ENOG410XNV4,-;ENOG410IE8X,-","GO:0016787,molecular_function,hydrolase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-562A8.5",24.78540237,5.516219614,2.144472621,2.402311738,0.001905282,0.004324641,"-","-","-","-","-","-","-","-"]
["PPM1K",0.647371779,0.144078553,2.144472621,2.402311738,0.001905282,0.004324641,"ENSG00000163644","H2QPV6,Protein phosphatase, Mg2+/Mn2+ dependent, 1K","-","PF00481,Protein phosphatase 2C","IPR015655,Protein phosphatase 2C family;IPR000222,PPM-type phosphatase, divalent cation binding;IPR001932,PPM-type phosphatase domain;IPR036457,PPM-type phosphatase domain superfamily","COG0631,Serine/threonine protein phosphatase;KOG0698,Serine/threonine protein phosphatase","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0043169,molecular_function,cation binding;GO:0003824,molecular_function,catalytic activity;GO:0046872,molecular_function,metal ion binding;GO:0006470,biological_process,protein dephosphorylation;GO:0004722,molecular_function,protein serine/threonine phosphatase activity","-"]
["SLC38A9",0.834326703,0.185687093,2.144472621,2.402311738,0.001905282,0.004324641,"ENSG00000177058","A0A024QZR9,Uncharacterized protein","NP_775785.2,sodium-coupled neutral amino acid transporter 9 isoform 1;XP_006714602.1,-;XP_006714600.1,-;XP_011541475.1,-;XP_011541476.1,-;XP_006714601.1,-","PF01490,Transmembrane amino acid transporter protein","IPR013057,Amino acid transporter, transmembrane domain","COG0814,Amino acid permeases;KOG1305,Amino acid transporter protein","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005654,cellular_component,nucleoplasm;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K14995,ko04150,mTOR signaling pathway"]
["TPST1",2.564007142,0.570643408,2.144472621,2.402311738,0.001905282,0.004324641,"ENSG00000169902","G2HIM6,Protein-tyrosine sulfotransferase 1","NP_001233396.1,-;XP_016801295.1,-","PF13469,Sulfotransferase family","IPR026634,Protein-tyrosine sulfotransferase;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG3988,Protein-tyrosine sulfotransferase TPST1/TPST2;ENOG410XQ2X,-","GO:0005794,cellular_component,Golgi apparatus;GO:0008476,molecular_function,protein-tyrosine sulfotransferase activity;GO:0006478,biological_process,peptidyl-tyrosine sulfation;GO:0016740,molecular_function,transferase activity","-"]
["LGALS3BP",44.45752162,10.05663475,2.143214441,6.626037496,{"v":1.87e-17,"d":"1.87E-17"},{"v":9.56e-16,"d":"9.56E-16"},"ENSG00000108679","A0A0S2Z3Y1,Lectin galactoside-binding soluble 3 binding protein isoform 1","NP_005558.1,galectin-3-binding protein precursor","PF00530,Scavenger receptor cysteine-rich domain;PF07707,BTB And C-terminal Kelch","IPR000210,BTB/POZ domain;IPR036772,SRCR-like domain superfamily;IPR011705,BTB/Kelch-associated;IPR017448,SRCR-like domain;IPR001190,SRCR domain","-","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0005044,molecular_function,scavenger receptor activity;GO:0005615,cellular_component,extracellular space;GO:0016020,cellular_component,membrane","-"]
["BBC3",7.317954163,1.648621107,2.142871782,3.925768608,{"v":1.07e-07,"d":"1.07E-07"},{"v":6.23e-07,"d":"6.23E-07"},"ENSG00000105327","H2QGP2,BCL2 binding component 3","-","-","IPR031661,Bcl-2-binding component 3","ENOG41119TR,-;ENOG410IW36,-","GO:0090200,biological_process,positive regulation of release of cytochrome c from mitochondria;GO:0097193,biological_process,intrinsic apoptotic signaling pathway;GO:0005739,cellular_component,mitochondrion;GO:0043065,biological_process,positive regulation of apoptotic process","-"]
["ASXL2",13.78483221,3.119885371,2.142571691,6.796518912,{"v":5.13e-18,"d":"5.13E-18"},{"v":2.92e-16,"d":"2.92E-16"},"ENSG00000143970","K6ZVJ0,Additional sex combs like 2","-","PF13919,Asx homology domain;PF05066,HB1, ASXL, restriction endonuclease HTH domain;PF13922,PHD domain of transcriptional enhancer, Asx","-","-","-","-"]
["TSEN15",35.57528169,8.047403481,2.142327505,5.763978674,{"v":1.35e-14,"d":"1.35E-14"},{"v":3.75e-13,"d":"3.75E-13"},"ENSG00000198860","G3RIB6,tRNA splicing endonuclease subunit 15","XP_018883394.1,-","PF09631,Sen15 protein","IPR036167,tRNA intron endonuclease, catalytic domain-like superfamily;IPR018593,tRNA-splicing endonuclease subunit Sen15;IPR011856,tRNA endonuclease-like domain superfamily","-","GO:0006388,biological_process,tRNA splicing, via endonucleolytic cleavage and ligation;GO:0003676,molecular_function,nucleic acid binding;GO:0000213,molecular_function,tRNA-intron endonuclease activity;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0004518,molecular_function,nuclease activity;GO:0090501,biological_process,RNA phosphodiester bond hydrolysis;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis","-"]
["ATN1",61.98298206,14.03682125,2.142081422,7.508604065,{"v":8.67e-20,"d":"8.67E-20"},{"v":6.84e-18,"d":"6.84E-18"},"ENSG00000111676","Q86V38,Atrophin 1","NP_001007027.1,-","PF03154,Atrophin-1 family","IPR002951,Atrophin-like;IPR017993,Atrophin-1","ENOG410ZIND,-;KOG2133,Transcriptional corepressor Atrophin-1/DRPLA","-","-"]
["UBOX5",1.854374288,0.414938934,2.140562315,2.629138194,0.00059626,1.51446E-3,"ENSG00000185019","Q53GQ5,Ubiquitin conjugating enzyme 7 interacting protein 5 isoform a variant","-","PF04564,U-box domain","IPR003613,U box domain;IPR001841,Zinc finger, RING-type;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG2042,Ubiquitin fusion degradation protein-2;COG5113,Ubiquitin fusion degradation protein 2","GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["LRRC37A15P",6.484151569,1.450908244,2.140562315,2.629138194,0.00059626,1.51446E-3,"ENSG00000230069","A0A096P669,Uncharacterized protein","-","PF14914,LRRC37A/B like protein 1 C-terminal domain","IPR015753,Leucine-rich repeat-containing protein 37;IPR029423,LRRC37A/B like protein 1, C-terminal","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["HNRNPUL1",116.4980997,26.44143344,2.13921227,8.872635182,{"v":5.51e-22,"d":"5.51E-22"},{"v":6.29e-20,"d":"6.29E-20"},"ENSG00000105323","K7CPM5,Heterogeneous nuclear ribonucleoprotein U-like 1","-","PF02037,SAP domain;PF13671,AAA domain;PF00622,SPRY domain","IPR035778,Heterogeneous nuclear ribonucleoprotein U, SPRY domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001870,B30.2/SPRY domain;IPR036361,SAP domain superfamily;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR003877,SPRY domain;IPR027025,Heterogeneous nuclear ribonucleoprotein U-like protein 1;IPR003034,SAP domain","ENOG410XSBV,-;KOG2242,Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain","GO:0009615,biological_process,response to virus;GO:0030529,,;GO:0006396,biological_process,RNA processing","-"]
["ANKRD17",51.19562637,11.61965709,2.139178746,8.567150129,1.23E-21,{"v":1.3e-19,"d":"1.30E-19"},"ENSG00000132466","K7A8P2,Ankyrin repeat domain 17","XP_001157805.3,ankyrin repeat domain-containing protein 17 isoform X1","PF12796,Ankyrin repeats (3 copies);PF00013,KH domain","IPR004088,K Homology domain, type 1;IPR004087,K Homology domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR036612,K Homology domain, type 1 superfamily","KOG0504,FOG: Ankyrin repeat;KOG4369,RTK signaling protein MASK/UNC-44;COG0666,FOG: Ankyrin repeat","GO:0031965,cellular_component,nuclear membrane;GO:0000785,cellular_component,chromatin;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0051151,biological_process,negative regulation of smooth muscle cell differentiation;GO:1900245,biological_process,positive regulation of MDA-5 signaling pathway;GO:0006275,biological_process,regulation of DNA replication;GO:0003723,molecular_function,RNA binding;GO:1900087,biological_process,positive regulation of G1/S transition of mitotic cell cycle;GO:1900246,biological_process,positive regulation of RIG-I signaling pathway;GO:0003682,molecular_function,chromatin binding;GO:0045087,biological_process,innate immune response;GO:0045787,biological_process,positive regulation of cell cycle;GO:0001955,biological_process,blood vessel maturation;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0005634,cellular_component,nucleus;GO:0042742,biological_process,defense response to bacterium","-"]
["RP11-1348G14.8",18.82400112,4.258134439,2.13843523,4.227058323,{"v":1.01e-08,"d":"1.01E-08"},{"v":7.43e-08,"d":"7.43E-08"},"ENSG00000275807","K9IUI6,Uncharacterized protein","-","PF07145,Ataxin-2 C-terminal region;PF06741,LsmAD domain;PF14438,Ataxin 2 SM domain","IPR009604,LsmAD domain;IPR009818,Ataxin-2, C-terminal;IPR025852,Ataxin 2, SM domain","-","-","-"]
["CYB5R4",3.006760532,0.680152455,2.13843523,4.227058323,{"v":1.01e-08,"d":"1.01E-08"},{"v":7.43e-08,"d":"7.43E-08"},"ENSG00000065615","H2QTC4,Cytochrome b5 reductase 4","XP_009449801.1,-","PF04969,CS domain;PF00173,Cytochrome b5-like Heme/Steroid binding domain;PF00175,Oxidoreductase NAD-binding domain;PF00970,Oxidoreductase FAD-binding domain","IPR017927,Ferredoxin reductase-type FAD-binding domain;IPR001199,Cytochrome b5-like heme/steroid binding domain;IPR017938,Riboflavin synthase-like beta-barrel;IPR018506,Cytochrome b5, heme-binding site;IPR007052,CS domain;IPR008978,HSP20-like chaperone;IPR001834,NADH:cytochrome b5 reductase (CBR);IPR036400,Cytochrome b5-like heme/steroid binding domain superfamily;IPR001433,Oxidoreductase FAD/NAD(P)-binding;IPR037908,Cytochrome b5 reductase 4, p23 domain;IPR008333,Oxidoreductase, FAD-binding domain","KOG0536,Flavohemoprotein b5+b5R;KOG0534,NADH-cytochrome b-5 reductase;COG5274,Cytochrome b involved in lipid metabolism;COG0543,2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases","GO:0046872,molecular_function,metal ion binding;GO:0016174,molecular_function,NAD(P)H oxidase activity;GO:0006801,biological_process,superoxide metabolic process;GO:0042593,biological_process,glucose homeostasis;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0030073,biological_process,insulin secretion;GO:0016491,molecular_function,oxidoreductase activity;GO:0046677,biological_process,response to antibiotic;GO:0005783,cellular_component,endoplasmic reticulum;GO:0055114,biological_process,oxidation-reduction process;GO:0004128,molecular_function,cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0020037,molecular_function,heme binding;GO:0016653,molecular_function,oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor;GO:0006091,biological_process,generation of precursor metabolites and energy;GO:0048468,biological_process,cell development","-"]
["NT5E",19.43474827,4.409324983,2.13808994,5.783952009,{"v":1.87e-14,"d":"1.87E-14"},{"v":5e-13,"d":"5.00E-13"},"ENSG00000135318","B2RBH2,cDNA, FLJ95508, highly similar to Homo sapiens 5'-nucleotidase, ecto","-","PF00149,Calcineurin-like phosphoesterase;PF02872,5'-nucleotidase, C-terminal domain","IPR006179,5'-Nucleotidase/apyrase;IPR029052,Metallo-dependent phosphatase-like;IPR008334,5'-Nucleotidase, C-terminal;IPR006146,5'-Nucleotidase, conserved site;IPR036907,5'-Nucleotidase, C-terminal domain superfamily;IPR004843,Calcineurin-like phosphoesterase domain, ApaH type","KOG4419,5' nucleotidase;COG0737,5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases","GO:0016787,molecular_function,hydrolase activity;GO:0009166,biological_process,nucleotide catabolic process;GO:0046872,molecular_function,metal ion binding;GO:0016788,molecular_function,hydrolase activity, acting on ester bonds;GO:0016020,cellular_component,membrane;GO:0000166,molecular_function,nucleotide binding;GO:0016021,cellular_component,integral component of membrane","-"]
["MTFR1L",1.755335439,0.394300175,2.137746163,2.824428154,0.000196752,0.000559224,"ENSG00000117640","G2HIT0,Family with sequence similarity 54, member B","NP_001233474.1,-;XP_016784340.1,-;XP_016784319.1,-;XP_016784375.1,-","PF05308,Mitochondrial fission regulator","IPR007972,Mitochondrial fission regulator 1","ENOG4111FGJ,-;ENOG410IEAK,-","GO:0000266,biological_process,mitochondrial fission;GO:0009060,biological_process,aerobic respiration;GO:0005739,cellular_component,mitochondrion","-"]
["LRRC8B",1.327627909,0.298224433,2.137746163,2.824428154,0.000196752,0.000559224,"ENSG00000197147","A0A1D5QGF5,Leucine rich repeat containing 8 family member B","XP_014999066.1,-;NP_001248286.1,volume-regulated anion channel subunit LRRC8B;XP_014999073.1,-;XP_014999057.1,-;XP_014999079.1,-","-","IPR001611,Leucine-rich repeat;IPR021040,LRRC8, pannexin-like TM region;IPR026906,Leucine rich repeat 5;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NUAK1",1.457018585,0.3272894,2.137746163,2.824428154,0.000196752,0.000559224,"ENSG00000074590","A0A024RBL3,NUAK family, SNF1-like kinase, 1, isoform CRA_a","NP_055655.1,NUAK family SNF1-like kinase 1","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XPDM,-;KOG0611,Predicted serine/threonine protein kinase","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0001650,cellular_component,fibrillar center;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["SETDB2",1.529018605,0.343462731,2.137746163,2.824428154,0.000196752,0.000559224,"ENSG00000136169","G3RIW1,SET domain bifurcated 2","-","PF00856,SET domain;PF01429,Methyl-CpG binding domain;PF05033,Pre-SET motif","IPR001214,SET domain;IPR001739,Methyl-CpG DNA binding;IPR016177,DNA-binding domain superfamily;IPR007728,Pre-SET domain","-","GO:0051567,biological_process,histone H3-K9 methylation;GO:0003677,molecular_function,DNA binding;GO:0005694,cellular_component,chromosome;GO:0034968,biological_process,histone lysine methylation;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0000278,biological_process,mitotic cell cycle;GO:0005829,cellular_component,cytosol;GO:0046974,molecular_function,histone methyltransferase activity (H3-K9 specific);GO:0007059,biological_process,chromosome segregation;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["KIAA1841",1.277625907,0.286992507,2.137746163,2.824428154,0.000196752,0.000559224,"ENSG00000162929","K7DMF7,KIAA1841","-","PF11822,omain of unknown function (DUF3342)","-","-","-","-"]
["CXorf57",2.104015299,0.472623968,2.137746163,2.824428154,0.000196752,0.000559224,"ENSG00000147231","A8K6R5,cDNA FLJ77568","-","-","IPR012340,Nucleic acid-binding, OB-fold","ENOG410IH30,-;ENOG410XQP7,-","-","-"]
["NUP133",5.233496623,1.185624308,2.136815667,4.35680974,{"v":5.53e-09,"d":"5.53E-09"},{"v":4.3e-08,"d":"4.30E-08"},"ENSG00000069248","K7C0W5,Nucleoporin 133kDa","-","PF03177,Non-repetitive/WGA-negative nucleoporin C-terminal","IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR007187,Nucleoporin, Nup133/Nup155-like, C-terminal;IPR037624,Nuclear pore complex protein Nup133-like","ENOG410XNUX,-;KOG4121,Nuclear pore complex, Nup133 component (sc Nup133)","GO:0005622,cellular_component,intracellular;GO:0006913,biological_process,nucleocytoplasmic transport;GO:0017056,molecular_function,structural constituent of nuclear pore","-"]
["SLIT2",3.27632408,0.742235975,2.136815667,4.35680974,{"v":5.53e-09,"d":"5.53E-09"},{"v":4.3e-08,"d":"4.30E-08"},"ENSG00000145147","X6R3P0,Slit homolog 2 protein","-","PF01463,Leucine rich repeat C-terminal domain;PF13855,Leucine rich repeat;PF00008,-like domain;PF01462,Leucine rich repeat N-terminal domain;PF00054,Laminin G domain;PF12661,Human growth factor-like EGF","IPR001611,Leucine-rich repeat;IPR018097,EGF-like calcium-binding, conserved site;IPR000483,Cysteine-rich flanking region, C-terminal;IPR001881,EGF-like calcium-binding domain;IPR032675,Leucine-rich repeat domain superfamily;IPR003645,Follistatin-like, N-terminal;IPR006207,Cystine knot, C-terminal;IPR000372,Leucine-rich repeat N-terminal domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR001791,Laminin G domain","KOG4237,Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats;COG4886,Leucine-rich repeat (LRR) protein","GO:0005576,cellular_component,extracellular region;GO:0005509,molecular_function,calcium ion binding","-"]
["HEATR6",2.390210994,0.538477313,2.135621289,2.995928332,{"v":4.71E-5,"d":"4.71E-05"},1.53962E-4,"ENSG00000068097","K7DTG6,HEAT repeat containing 6","-","PF13251,omain of unknown function (DUF4042)","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR025283,Domain of unknown function DUF4042","KOG4535,HEAT and armadillo repeat-containing protein;ENOG410XNWJ,-","-","-"]
["DHFRL1",2.497434454,0.562633089,2.135621289,2.995928332,{"v":4.71E-5,"d":"4.71E-05"},1.53962E-4,"ENSG00000178700","B3KV46,cDNA FLJ16119 fis, clone ASTRO2018540, highly similar to Dihydrofolate reductase-like protein 1","-","PF00186,ihydrofolate reductase","IPR001796,Dihydrofolate reductase domain;IPR024072,Dihydrofolate reductase-like domain superfamily","COG0262,Dihydrofolate reductase;KOG1324,Dihydrofolate reductase","GO:0055114,biological_process,oxidation-reduction process;GO:0004146,molecular_function,dihydrofolate reductase activity;GO:0046654,biological_process,tetrahydrofolate biosynthetic process","-"]
["MARK4",15.98974284,3.636336973,2.135008059,6.055258988,{"v":1.61e-15,"d":"1.61E-15"},5.59E-14,"ENSG00000007047","H2QL36,Non-specific serine/threonine protein kinase","XP_512745.3,MAP/microtubule affinity-regulating kinase 4 isoform X1","PF02149,Kinase associated domain 1;PF00627,UBA/TS-N domain;PF00069,Protein kinase domain","IPR028375,KA1 domain/Ssp2, C-terminal;IPR033624,Serine/threonine-protein kinase MARK/par1;IPR015940,Ubiquitin-associated domain;IPR001772,Kinase associated domain 1 (KA1);IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0586,Serine/threonine protein kinase;ENOG410XNQ0,-","GO:0004672,molecular_function,protein kinase activity;GO:0030010,biological_process,establishment of cell polarity;GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0050321,molecular_function,tau-protein kinase activity;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0043015,molecular_function,gamma-tubulin binding;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0005813,cellular_component,centrosome;GO:0007399,biological_process,nervous system development;GO:0005815,cellular_component,microtubule organizing center;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0036064,cellular_component,ciliary basal body;GO:0008017,molecular_function,microtubule binding;GO:0001578,biological_process,microtubule bundle formation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0043005,cellular_component,neuron projection;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["RAB6A",32.93207489,7.495569005,2.134338949,6.644561208,{"v":1.88e-17,"d":"1.88E-17"},{"v":9.56e-16,"d":"9.56E-16"},"ENSG00000175582","A0A024R5H8,RAB6A, member RAS oncogene family, isoform CRA_b","NP_002860.2,ras-related protein Rab-6A isoform a","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410XPBI,-;KOG0094,GTPase Rab6/YPT6/Ryh1, small G protein superfamily","GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity;GO:0005794,cellular_component,Golgi apparatus","-"]
["AP2B1",63.50423551,14.46780732,2.133657268,8.213794217,{"v":5.05e-21,"d":"5.05E-21"},{"v":4.92e-19,"d":"4.92E-19"},"ENSG00000006125","A0A1U8C2U8,AP complex subunit beta","XP_012973796.1,-","-","IPR013041,Clathrin adaptor, appendage, Ig-like subdomain superfamily;IPR008152,Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain;IPR012295,TBP domain superfamily;IPR000225,Armadillo;IPR026739,AP complex subunit beta;IPR015151,Beta-adaptin appendage, C-terminal subdomain;IPR016342,AP-1/2/4 complex subunit beta;IPR016024,Armadillo-type fold;IPR009028,Coatomer/calthrin adaptor appendage, C-terminal subdomain;IPR011989,Armadillo-like helical;IPR002553,Clathrin/coatomer adaptor, adaptin-like, N-terminal;IPR013037,Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain","-","GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0030131,cellular_component,clathrin adaptor complex;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0030117,cellular_component,membrane coat;GO:0030276,molecular_function,clathrin binding;GO:0006886,biological_process,intracellular protein transport","-"]
["TBC1D14",23.51391921,5.355178881,2.133361655,6.510401611,{"v":4.77e-17,"d":"4.77E-17"},{"v":2.27e-15,"d":"2.27E-15"},"ENSG00000132405","H2QP68,TBC1 domain family, member 14","XP_003950333.1,-;XP_526514.3,TBC1 domain family member 14 isoform X1","PF00566,Rab-GTPase-TBC domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain","KOG2223,Uncharacterized conserved protein, contains TBC domain;COG5210,GTPase-activating protein","GO:0071955,biological_process,recycling endosome to Golgi transport;GO:0019901,molecular_function,protein kinase binding;GO:0005096,molecular_function,GTPase activator activity;GO:0090630,biological_process,activation of GTPase activity;GO:0017137,molecular_function,Rab GTPase binding;GO:0005794,cellular_component,Golgi apparatus;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:2000785,biological_process,regulation of autophagosome assembly;GO:0005776,cellular_component,autophagosome;GO:0031338,biological_process,regulation of vesicle fusion;GO:0006886,biological_process,intracellular protein transport;GO:0055037,cellular_component,recycling endosome;GO:0005829,cellular_component,cytosol;GO:0010507,biological_process,negative regulation of autophagy;GO:0005654,cellular_component,nucleoplasm","-"]
["SLC6A6",4.890746874,1.11153095,2.133333836,4.687612195,{"v":2.76e-10,"d":"2.76E-10"},{"v":2.87e-09,"d":"2.87E-09"},"ENSG00000131389","A0A087WY96,Transporter","NP_001127839.2,sodium- and chloride-dependent taurine transporter isoform c","PF00209,Sodium:neurotransmitter symporter family","IPR002434,Sodium:neurotransmitter symporter, taurine;IPR000175,Sodium:neurotransmitter symporter;IPR037272,Sodium:neurotransmitter symporter superfamily","KOG3659,Sodium-neurotransmitter symporter;COG0733,Na+-dependent transporters of the SNF family","GO:0005369,molecular_function,taurine:sodium symporter activity;GO:0005328,molecular_function,neurotransmitter:sodium symporter activity;GO:0055085,biological_process,transmembrane transport;GO:0015293,molecular_function,symporter activity;GO:0005368,molecular_function,taurine transmembrane transporter activity;GO:0015734,biological_process,taurine transport;GO:0016020,cellular_component,membrane;GO:0006836,biological_process,neurotransmitter transport;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["DIMT1",18.11459888,4.122104368,2.133212582,5.412026196,{"v":5.18e-13,"d":"5.18E-13"},{"v":9.98e-12,"d":"9.98E-12"},"ENSG00000086189","H2QQY8,rRNA adenine N","XP_517743.2,-","PF08241,Methyltransferase domain;PF13649,Methyltransferase domain;PF00398,Ribosomal RNA adenine dimethylase","IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR001737,Ribosomal RNA adenine methyltransferase KsgA/Erm;IPR020596,Ribosomal RNA adenine methylase transferase, conserved site;IPR020598,Ribosomal RNA adenine methylase transferase, N-terminal;IPR011530,Ribosomal RNA adenine dimethylase","COG0030,Dimethyladenosine transferase (rRNA methylation);KOG0820,Ribosomal RNA adenine dimethylase","GO:0008649,molecular_function,rRNA methyltransferase activity;GO:0031167,biological_process,rRNA methylation;GO:2000234,biological_process,positive regulation of rRNA processing;GO:0005730,cellular_component,nucleolus;GO:0016740,molecular_function,transferase activity;GO:0003723,molecular_function,RNA binding;GO:0005759,cellular_component,mitochondrial matrix;GO:0008168,molecular_function,methyltransferase activity;GO:0000179,molecular_function,rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0032259,biological_process,methylation;GO:0005829,cellular_component,cytosol;GO:0000154,biological_process,rRNA modification;GO:0005634,cellular_component,nucleus;GO:0006364,biological_process,rRNA processing","-"]
["CTGF",28.93379282,6.584088037,2.133212582,5.412026196,{"v":5.18e-13,"d":"5.18E-13"},{"v":9.98e-12,"d":"9.98E-12"},"ENSG00000118523","Q5M8T4,Connective tissue growth factor","NP_001892.1,connective tissue growth factor precursor","PF00093,von Willebrand factor type C domain;PF00090,Thrombospondin type 1 domain;PF00007,Cystine-knot domain;PF00219,Insulin-like growth factor binding protein","IPR012395,IGFBP-related, CNN;IPR000867,Insulin-like growth factor-binding protein, IGFBP;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR017891,Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR006207,Cystine knot, C-terminal;IPR001007,VWFC domain;IPR006208,Glycoprotein hormone subunit beta;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","ENOG410IH0W,-;ENOG4111F77,-","GO:0001558,biological_process,regulation of cell growth;GO:0005520,molecular_function,insulin-like growth factor binding;GO:0005576,cellular_component,extracellular region","K06827,ko04390,Hippo signaling pathway"]
["DMWD",12.21295551,2.779753511,2.132948074,5.441458703,{"v":3.15e-13,"d":"3.15E-13"},{"v":6.46e-12,"d":"6.46E-12"},"ENSG00000185800","A0A0D9S230,DM1 locus, WD repeat containing","XP_007995447.1,dystrophia myotonica WD repeat-containing protein isoform X1","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","-","-","-"]
["ZNF627",3.78496704,0.856188777,2.132627907,3.286821223,{"v":1.46e-05,"d":"1.46E-05"},{"v":5.34e-05,"d":"5.34E-05"},"ENSG00000198551","G3SCR4,Zinc finger protein 627","XP_004060096.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["LATS1",5.330009046,1.213147083,2.131732805,4.872152994,{"v":5.63e-11,"d":"5.63E-11"},{"v":6.76e-10,"d":"6.76E-10"},"ENSG00000131023","H2PKK8,Large tumor suppressor kinase 1","XP_009240630.1,serine/threonine-protein kinase LATS1;XP_009240631.1,-","PF00069,Protein kinase domain;PF00627,UBA/TS-N domain","IPR028741,Serine/threonine-protein kinase LATS1;IPR009060,UBA-like superfamily;IPR015940,Ubiquitin-associated domain;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XQC0,-;KOG0605,NDR and related serine/threonine kinases","GO:0019901,molecular_function,protein kinase binding;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:0030833,biological_process,regulation of actin filament polymerization;GO:0033146,biological_process,regulation of intracellular estrogen receptor signaling pathway;GO:0035329,biological_process,hippo signaling;GO:0004672,molecular_function,protein kinase activity;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:0000287,molecular_function,magnesium ion binding;GO:0016310,biological_process,phosphorylation;GO:0001827,biological_process,inner cell mass cell fate commitment;GO:0030331,molecular_function,estrogen receptor binding;GO:0016301,molecular_function,kinase activity;GO:0060644,biological_process,mammary gland epithelial cell differentiation;GO:2000058,biological_process,regulation of ubiquitin-dependent protein catabolic process;GO:0009755,biological_process,hormone-mediated signaling pathway;GO:0005524,molecular_function,ATP binding;GO:0051220,biological_process,cytoplasmic sequestering of protein;GO:0000278,biological_process,mitotic cell cycle;GO:0000086,biological_process,G2/M transition of mitotic cell cycle;GO:0034613,biological_process,cellular protein localization;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0016740,molecular_function,transferase activity;GO:0043254,biological_process,regulation of protein complex assembly;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0000819,biological_process,sister chromatid segregation;GO:0045736,biological_process,negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0001828,biological_process,inner cell mass cellular morphogenesis;GO:0000922,cellular_component,spindle pole;GO:0030216,biological_process,keratinocyte differentiation","K08791,ko04392,Hippo signaling pathway -multiple species;K08791,ko04391,Hippo signaling pathway - fly;K08791,ko04214,Apoptosis - fly;K08791,ko04390,Hippo signaling pathway"]
["LSM12",5.659846935,1.282211987,2.131533994,3.412548274,{"v":5.78e-06,"d":"5.78E-06"},{"v":2.32e-05,"d":"2.32E-05"},"ENSG00000161654","K7ELG9,Protein LSM12 homolog","-","PF09793,Anticodon-binding domain","IPR019181,Anticodon-binding domain","ENOG410Y6A1,-;KOG4401,Uncharacterized conserved protein","-","-"]
["CHEK2",4.185077404,0.949290522,2.130620183,3.528033404,{"v":2.37e-06,"d":"2.37E-06"},{"v":1.04E-5,"d":"1.04E-05"},"ENSG00000183765","F6SZM3,Checkpoint kinase 2","-","PF00069,Protein kinase domain","IPR008984,SMAD/FHA domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR000253,Forkhead-associated (FHA) domain;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0615,Serine/threonine protein kinase Chk2 and related proteins;ENOG410YA63,-","GO:0019901,molecular_function,protein kinase binding;GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0042176,biological_process,regulation of protein catabolic process;GO:0016605,cellular_component,PML body;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding;GO:0006975,biological_process,DNA damage induced protein phosphorylation;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0005794,cellular_component,Golgi apparatus;GO:0050821,biological_process,protein stabilization;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006302,biological_process,double-strand break repair;GO:0000086,biological_process,G2/M transition of mitotic cell cycle;GO:0042802,molecular_function,identical protein binding;GO:0042771,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0001302,biological_process,replicative cell aging;GO:0006978,biological_process,DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0006915,biological_process,apoptotic process;GO:0006468,biological_process,protein phosphorylation;GO:0071480,biological_process,cellular response to gamma radiation;GO:0005654,cellular_component,nucleoplasm;GO:0000781,cellular_component,chromosome, telomeric region;GO:0072428,biological_process,signal transduction involved in intra-S DNA damage checkpoint;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0046777,biological_process,protein autophosphorylation;GO:0042770,biological_process,signal transduction in response to DNA damage;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0010332,biological_process,response to gamma radiation;GO:0090307,biological_process,mitotic spindle assembly;GO:0044257,biological_process,cellular protein catabolic process","-"]
["TUBG1",81.54997938,18.61878556,2.130072283,6.928853363,{"v":3.61e-18,"d":"3.61E-18"},{"v":2.13e-16,"d":"2.13E-16"},"ENSG00000131462","H0X1H2,Tubulin gamma chain","XP_012658492.1,-","PF03953,Tubulin C-terminal domain;PF00091,Tubulin/FtsZ family, GTPase domain","IPR017975,Tubulin, conserved site;IPR003008,Tubulin/FtsZ, GTPase domain;IPR008280,Tubulin/FtsZ, C-terminal;IPR036525,Tubulin/FtsZ, GTPase domain superfamily;IPR037103,Tubulin/FtsZ, C-terminal domain superfamily;IPR002454,Gamma tubulin;IPR018316,Tubulin/FtsZ, 2-layer sandwich domain;IPR000217,Tubulin;IPR023123,Tubulin, C-terminal","COG5023,Tubulin;KOG1374,Gamma tubulin","GO:0097730,cellular_component,non-motile cilium;GO:0005525,molecular_function,GTP binding;GO:0007017,biological_process,microtubule-based process;GO:0005737,cellular_component,cytoplasm;GO:0000242,cellular_component,pericentriolar material;GO:0036064,cellular_component,ciliary basal body;GO:0005813,cellular_component,centrosome;GO:0003924,molecular_function,GTPase activity;GO:0042802,molecular_function,identical protein binding;GO:0045177,cellular_component,apical part of cell;GO:0000212,biological_process,meiotic spindle organization;GO:0005814,cellular_component,centriole;GO:0031122,biological_process,cytoplasmic microtubule organization;GO:0000794,cellular_component,condensed nuclear chromosome;GO:0000166,molecular_function,nucleotide binding;GO:0005874,cellular_component,microtubule;GO:0007020,biological_process,microtubule nucleation;GO:0000930,cellular_component,gamma-tubulin complex;GO:0005929,cellular_component,cilium;GO:0031252,cellular_component,cell leading edge;GO:0005827,cellular_component,polar microtubule;GO:0005876,cellular_component,spindle microtubule;GO:0055037,cellular_component,recycling endosome;GO:0005881,cellular_component,cytoplasmic microtubule","-"]
["RP11-815J21.2",19.68452411,4.46970072,2.129845377,3.634830075,{"v":1.55E-6,"d":"1.55E-06"},{"v":7.04e-06,"d":"7.04E-06"},"ENSG00000259375","H0YMW2,A-kinase anchor protein 13","-","PF10522,RII binding domain","IPR028852,A-kinase anchor protein 13;IPR018459,RII binding domain","COG5422,RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases;KOG3520,Predicted guanine nucleotide exchange factor","GO:0004691,molecular_function,cAMP-dependent protein kinase activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0006468,biological_process,protein phosphorylation","-"]
["VPS50",1.984276653,0.450563231,2.129845377,3.634830075,{"v":1.55E-6,"d":"1.55E-06"},{"v":7.04e-06,"d":"7.04E-06"},"ENSG00000004766","G7P1D5,Uncharacterized protein","XP_005550271.1,syndetin","PF10474,Protein of unknown function C-terminus (DUF2451);PF10475,Vacuolar-sorting protein 54, of GARP complex","IPR019514,Protein of unknown function DUF2451, C-terminal;IPR019515,Vacuolar protein sorting-associated protein 54, N-terminal","-","GO:0000149,molecular_function,SNARE binding;GO:1990745,cellular_component,EARP complex;GO:0032456,biological_process,endocytic recycling;GO:0055037,cellular_component,recycling endosome","-"]
["ZW10",6.746026855,1.533184569,2.129180102,3.73416231,{"v":6.8e-07,"d":"6.80E-07"},{"v":3.34e-06,"d":"3.34E-06"},"ENSG00000086827","H2Q4S8,ZW10, kinetochore associated, homolog","XP_508761.2,-","PF06248,Centromere/kinetochore Zw10","IPR009361,RZZ complex, subunit Zw10","KOG2163,Centromere/kinetochore protein zw10 involved in mitotic chromosome segregation;ENOG410XQ7J,-","GO:0007080,biological_process,mitotic metaphase plate congression;GO:0065003,biological_process,protein-containing complex assembly;GO:0007096,biological_process,regulation of exit from mitosis;GO:0000776,cellular_component,kinetochore;GO:0000070,biological_process,mitotic sister chromatid segregation;GO:0000132,biological_process,establishment of mitotic spindle orientation;GO:1990423,cellular_component,RZZ complex;GO:0007094,biological_process,mitotic spindle assembly checkpoint;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005828,cellular_component,kinetochore microtubule;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0000278,biological_process,mitotic cell cycle;GO:0000922,cellular_component,spindle pole;GO:0034501,biological_process,protein localization to kinetochore;GO:0000775,cellular_component,chromosome, centromeric region;GO:0070939,cellular_component,Dsl1/NZR complex;GO:0005829,cellular_component,cytosol;GO:0007093,biological_process,mitotic cell cycle checkpoint;GO:0005634,cellular_component,nucleus;GO:0007030,biological_process,Golgi organization","-"]
["VEPH1",3.297051148,0.749916338,2.128602664,3.827011788,{"v":3.08e-07,"d":"3.08E-07"},{"v":1.62e-06,"d":"1.62E-06"},"ENSG00000197415","H2R137,Ventricular zone expressed PH domain homolog 1","XP_001152941.1,ventricular zone-expressed PH domain-containing protein homolog 1 isoform X2;XP_009445018.1,-","PF00169,PH domain","IPR016024,Armadillo-type fold;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","KOG3723,PH domain protein Melted;ENOG410XQXD,-","-","-"]
["ITGA2",26.08759371,5.965048811,2.127946595,6.998381607,2.31E-18,1.41E-16,"ENSG00000164171","H2QQV6,Integrin, alpha 2","XP_526928.2,integrin alpha-2 isoform X1","PF01839,-GAP repeat;PF08441,Integrin alpha;PF00092,von Willebrand factor type A domain","IPR013517,FG-GAP repeat;IPR036465,von Willebrand factor A-like domain superfamily;IPR018184,Integrin alpha chain, C-terminal cytoplasmic region, conserved site;IPR032695,Integrin domain superfamily;IPR013649,Integrin alpha-2;IPR013519,Integrin alpha beta-propellor;IPR000413,Integrin alpha chain;IPR002035,von Willebrand factor, type A;IPR028994,Integrin alpha, N-terminal","ENOG4110534,-;ENOG410IPB9,-","GO:0008305,cellular_component,integrin complex;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0007155,biological_process,cell adhesion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF33A",3.251149138,0.740433147,2.127649834,3.996320453,{"v":1.38e-07,"d":"1.38E-07"},{"v":7.85E-7,"d":"7.85E-07"},"ENSG00000189180","A0A0A0MR11,Zinc finger protein 33A","NP_001265102.1,zinc finger protein 33A isoform e","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["PSME4",2.388281903,0.543919399,2.127649834,3.996320453,{"v":1.38e-07,"d":"1.38E-07"},{"v":7.85E-7,"d":"7.85E-07"},"ENSG00000068878","K7BAR3,Proteasome","XP_003309060.2,proteasome activator complex subunit 4 isoform X4","PF16507,Proteasome-substrate-size regulator, mid region;PF11919,omain of unknown function (DUF3437)","IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR021843,Proteasome activator complex subunit 4 C-terminal domain;IPR035309,Proteasome activator complex subunit 4;IPR032430,Proteasome activator Blm10, mid region","KOG1851,Uncharacterized conserved protein;ENOG410XP7J,-","GO:0000502,cellular_component,proteasome complex;GO:0016504,molecular_function,peptidase activator activity;GO:0070628,molecular_function,proteasome binding;GO:0010952,biological_process,positive regulation of peptidase activity;GO:0070577,molecular_function,lysine-acetylated histone binding","K06699,ko03050,Proteasome"]
["VGLL4",3.591391125,0.818362982,2.127252175,4.073990158,{"v":5.11e-08,"d":"5.11E-08"},{"v":3.21e-07,"d":"3.21E-07"},"ENSG00000144560","G5E9M7,Transcription cofactor vestigial-like protein 4","NP_001121691.1,transcription cofactor vestigial-like protein 4 isoform a","PF15245,Transcription cofactor vestigial-like protein 4","IPR006627,TDU repeat;IPR028184,Transcription cofactor vestigial-like protein 4","ENOG410XX71,-;ENOG410IFGD,-","GO:0006355,biological_process,regulation of transcription, DNA-templated","-"]
["COPA",12.42169566,2.83918903,2.127148858,5.602886001,{"v":7.98e-14,"d":"7.98E-14"},{"v":1.86e-12,"d":"1.86E-12"},"ENSG00000122218","H2Q0E3,Coatomer subunit alpha","XP_001171563.1,coatomer subunit alpha isoform X1","PF12894,Anaphase-promoting complex subunit 4 WD40 domain;PF06957,Coatomer (COPI) alpha subunit C-terminus;PF00400,WD domain, G-beta repeat;PF04053,Coatomer WD associated region","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR024977,Anaphase-promoting complex subunit 4, WD40 domain;IPR006692,Coatomer, WD associated region;IPR036322,WD40-repeat-containing domain superfamily;IPR010714,Coatomer, alpha subunit, C-terminal;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat;IPR016391,Coatomer alpha subunit","ENOG410XPZS,-;KOG0292,Vesicle coat complex COPI, alpha subunit","GO:0005794,cellular_component,Golgi apparatus;GO:0030126,cellular_component,COPI vesicle coat;GO:0006891,biological_process,intra-Golgi vesicle-mediated transport;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0016020,cellular_component,membrane;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0000139,cellular_component,Golgi membrane;GO:0030157,biological_process,pancreatic juice secretion;GO:0006890,biological_process,retrograde vesicle-mediated transport, Golgi to ER;GO:0005198,molecular_function,structural molecule activity;GO:0016192,biological_process,vesicle-mediated transport;GO:0006886,biological_process,intracellular protein transport;GO:0030117,cellular_component,membrane coat;GO:0005615,cellular_component,extracellular space","-"]
["ZFP36L1",85.96425415,19.68520697,2.126248149,8.096336921,{"v":9.45e-21,"d":"9.45E-21"},{"v":8.79e-19,"d":"8.79E-19"},"ENSG00000185650","A0A024R658,Zinc finger protein 36, C3H type-like 1, isoform CRA_a","NP_004917.2,mRNA decay activator protein ZFP36L1 isoform 1;NP_001231627.1,-","PF04553,Tis11B like protein, N terminus;PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type;IPR007635,Tis11B-like protein, N-terminal","KOG1677,CCCH-type Zn-finger protein;COG5063,CCCH-type Zn-finger protein","GO:0072091,biological_process,regulation of stem cell proliferation;GO:0071472,biological_process,cellular response to salt stress;GO:0001570,biological_process,vasculogenesis;GO:0044344,biological_process,cellular response to fibroblast growth factor stimulus;GO:0006417,biological_process,regulation of translation;GO:0061158,biological_process,3'-UTR-mediated mRNA destabilization;GO:0035264,biological_process,multicellular organism growth;GO:0035925,molecular_function,mRNA 3'-UTR AU-rich region binding;GO:0045661,biological_process,regulation of myoblast differentiation;GO:0048568,biological_process,embryonic organ development;GO:0045577,biological_process,regulation of B cell differentiation;GO:1901991,biological_process,negative regulation of mitotic cell cycle phase transition;GO:0005634,cellular_component,nucleus;GO:0003729,molecular_function,mRNA binding;GO:0045600,biological_process,positive regulation of fat cell differentiation;GO:0007507,biological_process,heart development;GO:0005737,cellular_component,cytoplasm;GO:0000288,biological_process,nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0017091,molecular_function,AU-rich element binding;GO:0060712,biological_process,spongiotrophoblast layer development;GO:0071375,biological_process,cellular response to peptide hormone stimulus;GO:0005829,cellular_component,cytosol;GO:0038066,biological_process,p38MAPK cascade;GO:0006915,biological_process,apoptotic process;GO:0097403,biological_process,cellular response to raffinose;GO:0003342,biological_process,proepicardium development;GO:0000165,biological_process,MAPK cascade;GO:0048382,biological_process,mesendoderm development;GO:0043491,biological_process,protein kinase B signaling;GO:0033077,biological_process,T cell differentiation in thymus;GO:0060710,biological_process,chorio-allantoic fusion;GO:0031086,biological_process,nuclear-transcribed mRNA catabolic process, deadenylation-independent decay;GO:0021915,biological_process,neural tube development;GO:0008283,biological_process,cell proliferation;GO:0046872,molecular_function,metal ion binding;GO:0006402,biological_process,mRNA catabolic process;GO:1900153,biological_process,positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0071320,biological_process,cellular response to cAMP;GO:0030529,,;GO:0043488,biological_process,regulation of mRNA stability","-"]
["PTPN3",16.60676754,3.802797362,2.125631564,6.68759632,{"v":1.97e-17,"d":"1.97E-17"},{"v":9.9e-16,"d":"9.90E-16"},"ENSG00000070159","H2RBV9,Tyrosine-protein phosphatase non-receptor type","-","PF00102,Protein-tyrosine phosphatase;PF09379,RM N-terminal domain;PF00595,PDZ domain (Also known as DHR or GLGF);PF00373,RM central domain;PF09380,RM C-terminal PH-like domain","IPR019747,FERM conserved site;IPR029021,Protein-tyrosine phosphatase-like;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR018979,FERM, N-terminal;IPR019748,FERM central domain;IPR000387,Tyrosine specific protein phosphatases domain;IPR000299,FERM domain;IPR019749,Band 4.1 domain;IPR000242,PTP type protein phosphatase;IPR011993,PH-like domain superfamily;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR012151,Protein-tyrosine phosphatase, non-receptor type-3, -4;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR035963,FERM superfamily, second domain;IPR016130,Protein-tyrosine phosphatase, active site;IPR029071,Ubiquitin-like domain superfamily;IPR018980,FERM, C-terminal PH-like domain","ENOG410KDUQ,-;COG5599,Protein tyrosine phosphatase","GO:0016787,molecular_function,hydrolase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0006470,biological_process,protein dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005856,cellular_component,cytoskeleton;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","-"]
["EXPH5",3.963874047,0.906566758,2.12453795,4.776527739,{"v":1.25e-10,"d":"1.25E-10"},{"v":1.39E-9,"d":"1.39E-09"},"ENSG00000110723","Q149M6,Exophilin 5","NP_001138236.1,exophilin-5 isoform 5;NP_055880.2,exophilin-5 isoform 1;NP_001138237.1,exophilin-5 isoform 3;NP_001138235.1,exophilin-5 isoform 4;NP_001294948.1,exophilin-5 isoform 2","-","IPR010911,Rab-binding domain","ENOG4111DX8,-;ENOG410IEGS,-","GO:0017137,molecular_function,Rab GTPase binding;GO:0006886,biological_process,intracellular protein transport;GO:0005622,cellular_component,intracellular","-"]
["RP11-649E7.5",17.98503328,4.114040825,2.124406167,4.822073674,1.12E-10,{"v":1.26E-9,"d":"1.26E-09"},"ENSG00000258377","B4DDK9,cDNA FLJ55952, highly similar to Alpha-1,6-mannosyl-glycoprotein2-beta-N- acetylglucosaminyltransferase","-","PF05060,N-acetylglucosaminyltransferase II (MGAT2)","IPR029044,Nucleotide-diphospho-sugar transferases;IPR007754,N-acetylglucosaminyltransferase II","KOG2791,N-acetylglucosaminyltransferase;ENOG410XPYF,-","GO:0005795,cellular_component,Golgi stack;GO:0008455,molecular_function,alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;GO:0009312,biological_process,oligosaccharide biosynthetic process;GO:0016740,molecular_function,transferase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["KIAA1143",8.443629429,1.931463548,2.124406167,4.822073674,1.12E-10,{"v":1.26E-9,"d":"1.26E-09"},"ENSG00000163807","G3QJE6,KIAA1143","XP_004034024.1,-","PF15377,omain of unknown function (DUF4604)","IPR027911,Domain of unknown function DUF4604","-","-","-"]
["LINC01278",7.407833346,1.695076609,2.124166453,4.909046304,{"v":4.36e-11,"d":"4.36E-11"},5.39E-10,"ENSG00000235437","A0A1U7Q461,syncytin b precursor","NP_001292155.1,syncytin b precursor","-","IPR018154,TLV/ENV coat polyprotein","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NETO2",6.697512452,1.532979625,2.12395402,4.991050239,3.12E-11,{"v":4.01e-10,"d":"4.01E-10"},"ENSG00000171208","G3SFF0,Neuropilin and tolloid like 2","XP_004057653.1,neuropilin and tolloid-like protein 2 isoform X1","PF00431,CUB domain;PF00057,Low-density lipoprotein receptor domain class A","IPR035914,Spermadhesin, CUB domain superfamily;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR000859,CUB domain;IPR028868,Neuropilin and tolloid-like protein 2;IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR036055,LDL receptor-like superfamily","-","GO:0035255,molecular_function,ionotropic glutamate receptor binding;GO:2000312,biological_process,regulation of kainate selective glutamate receptor activity;GO:0014069,cellular_component,postsynaptic density;GO:0016020,cellular_component,membrane;GO:0045202,cellular_component,synapse;GO:0016021,cellular_component,integral component of membrane","-"]
["MTMR1",11.98003896,2.746506815,2.122761586,5.572983747,1.25E-13,{"v":2.78e-12,"d":"2.78E-12"},"ENSG00000063601","F8WA39,Myotubularin-related protein 1","NP_001293073.1,myotubularin-related protein 1 isoform 1","PF06602,Myotubularin-like phosphatase domain;PF02893,RAM domain","IPR004182,GRAM domain;IPR029021,Protein-tyrosine phosphatase-like;IPR016130,Protein-tyrosine phosphatase, active site;IPR037857,MTMR1, PH-GRAM;IPR010569,Myotubularin-like phosphatase domain;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR030587,Myotubularin-related protein 1;IPR000387,Tyrosine specific protein phosphatases domain;IPR030564,Myotubularin family;IPR011993,PH-like domain superfamily","ENOG410XPTU,-;KOG1089,Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6","GO:0046856,biological_process,phosphatidylinositol dephosphorylation;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0052629,molecular_function,phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0005886,cellular_component,plasma membrane;GO:0004438,molecular_function,phosphatidylinositol-3-phosphatase activity;GO:0016311,biological_process,dephosphorylation;GO:0052866,molecular_function,phosphatidylinositol phosphate phosphatase activity;GO:0016791,molecular_function,phosphatase activity","-"]
["TNRC6A",17.56514228,4.031142662,2.122720404,7.135914494,{"v":1.29e-18,"d":"1.29E-18"},{"v":8.25e-17,"d":"8.25E-17"},"ENSG00000090905","G3QR11,Trinucleotide repeat containing 6A","-","PF16608,TNRC6-PABC binding domain;PF10427,Argonaute hook","IPR034924,TNRC6A, RNA recognition motif;IPR032226,TNRC6, PABC binding domain;IPR033501,Trinucleotide repeat-containing gene 6A protein;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR019486,Argonaute hook domain;IPR035979,RNA-binding domain superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0035278,biological_process,miRNA mediated inhibition of translation","-"]
["VPS39",9.238035338,2.118006468,2.122718584,5.599330954,{"v":9.3e-14,"d":"9.30E-14"},{"v":2.14e-12,"d":"2.14E-12"},"ENSG00000166887","G3QDP3,VPS39, HOPS complex subunit","XP_004056090.1,vam6/Vps39-like protein isoform X1","PF10367,Vacuolar sorting protein 39 domain 2;PF10366,Vacuolar sorting protein 39 domain 1;PF00780,CNH domain","IPR019453,Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2;IPR000547,Clathrin, heavy chain/VPS, 7-fold repeat;IPR001180,Citron homology (CNH) domain;IPR032914,Vam6/VPS39/TRAP1 family;IPR019452,Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1","-","GO:1902774,biological_process,late endosome to lysosome transport;GO:0030123,cellular_component,AP-3 adaptor complex;GO:0006914,biological_process,autophagy;GO:0034058,biological_process,endosomal vesicle fusion;GO:0005765,cellular_component,lysosomal membrane;GO:1990126,biological_process,retrograde transport, endosome to plasma membrane;GO:0031902,cellular_component,late endosome membrane;GO:0030897,cellular_component,HOPS complex;GO:0016192,biological_process,vesicle-mediated transport;GO:0008333,biological_process,endosome to lysosome transport;GO:0006886,biological_process,intracellular protein transport","-"]
["PRRC2A",62.94061558,14.45098244,2.122533321,8.46685992,{"v":3.03e-21,"d":"3.03E-21"},3.09E-19,"ENSG00000204469","A0A1U9X974,PRRC2A","NP_004629.3,-;NP_542417.2,protein PRRC2A","-","IPR009738,BAT2, N-terminal;IPR033184,Protein PRRC2","-","-","-"]
["GSE1",6.935602959,1.590955698,2.122332699,5.861189451,{"v":1.03e-14,"d":"1.03E-14"},2.96E-13,"ENSG00000131149","G3R111,Gse1 coiled-coil protein","-","PF12540,Protein of unknown function (DUF3736)","IPR022207,Genetic suppressor element-like","-","-","-"]
["FAM171B",20.3385878,4.66805114,2.121921485,6.207746626,8.19E-16,{"v":3.03e-14,"d":"3.03E-14"},"ENSG00000144369","A8K122,KIAA1946, isoform CRA_b","-","PF10577,Uncharacterised protein family UPF0560","IPR018890,Uncharacterised protein family FAM171","ENOG410YAPI,-;ENOG410IEWE,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SPIRE1",30.13693516,6.92246715,2.121328949,6.93217754,{"v":4.38e-18,"d":"4.38E-18"},{"v":2.53e-16,"d":"2.53E-16"},"ENSG00000134278","K7B541,Spire homolog 1","XP_016788750.1,protein spire homolog 1 isoform X4","PF16474,Kinase non-catalytic C-lobe domain","IPR029905,Protein Spire1;IPR011019,KIND domain;IPR029901,Protein Spire;IPR011011,Zinc finger, FYVE/PHD-type","ENOG4111E0J,-;ENOG410IK9H,-","GO:0045010,biological_process,actin nucleation;GO:0003779,molecular_function,actin binding;GO:0016192,biological_process,vesicle-mediated transport","-"]
["KPNB1",99.86439296,23.00216162,2.117984544,8.885059453,1.12E-21,{"v":1.2e-19,"d":"1.20E-19"},"ENSG00000108424","G1QLY2,Karyopherin subunit beta 1","XP_003278763.1,-","PF13513,HEAT-like repeat;PF03810,Importin-beta N-terminal domain","IPR000225,Armadillo;IPR016024,Armadillo-type fold;IPR001494,Importin-beta, N-terminal domain;IPR011989,Armadillo-like helical;IPR021133,HEAT, type 2","COG5215,Karyopherin (importin) beta;KOG1241,Karyopherin (importin) beta 1","GO:0006610,biological_process,ribosomal protein import into nucleus;GO:0007079,biological_process,mitotic chromosome movement towards spindle pole;GO:0045184,biological_process,establishment of protein localization;GO:0007080,biological_process,mitotic metaphase plate congression;GO:0030953,biological_process,astral microtubule organization;GO:0006606,biological_process,protein import into nucleus;GO:0019899,molecular_function,enzyme binding;GO:0008536,molecular_function,Ran GTPase binding;GO:0019904,molecular_function,protein domain specific binding;GO:0040001,biological_process,establishment of mitotic spindle localization;GO:0071782,cellular_component,endoplasmic reticulum tubular network;GO:0006886,biological_process,intracellular protein transport;GO:0031291,biological_process,Ran protein signal transduction;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0005635,cellular_component,nuclear envelope;GO:0090307,biological_process,mitotic spindle assembly","K14293,ko03013,RNA transport"]
["EXT2",12.12906531,2.789416388,2.117843583,5.338534238,{"v":1.45e-12,"d":"1.45E-12"},{"v":2.52e-11,"d":"2.52E-11"},"ENSG00000151348","K7CFL0,Exostosin 2","XP_003313042.2,-","PF09258,lycosyl transferase family 64 domain;PF03016,xostosin family","IPR004263,Exostosin-like;IPR029044,Nucleotide-diphospho-sugar transferases;IPR027673,Exostosin-2;IPR015338,Exostosin , C-terminal","KOG1021,Acetylglucosaminyltransferase EXT1/exostosin 1;ENOG410XTFH,-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0006024,biological_process,glycosaminoglycan biosynthetic process;GO:0006486,biological_process,protein glycosylation;GO:0016020,cellular_component,membrane;GO:0015012,biological_process,heparan sulfate proteoglycan biosynthetic process;GO:0016021,cellular_component,integral component of membrane;GO:0015020,molecular_function,glucuronosyltransferase activity","K02367,ko00534,Glycosaminoglycan biosynthesis - heparan sulfate / heparin"]
["ATF3",14.45920687,3.325297339,2.117591338,5.207563999,{"v":4.53e-12,"d":"4.53E-12"},{"v":7.01e-11,"d":"7.01E-11"},"ENSG00000162772","G1QRJ9,Activating transcription factor 3","XP_012362230.1,-;XP_003273102.1,-;XP_003273105.1,-","PF00170,bZIP transcription factor","IPR000837,AP-1 transcription factor;IPR029812,cAMP-dependent transcription factor ATF-3;IPR004827,Basic-leucine zipper domain","KOG1414,Transcriptional activator FOSB/c-Fos and related bZIP transcription factors;ENOG4111CH5,-","GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006094,biological_process,gluconeogenesis;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0010628,biological_process,positive regulation of gene expression;GO:0005634,cellular_component,nucleus;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0042802,molecular_function,identical protein binding;GO:0003677,molecular_function,DNA binding;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:1990622,cellular_component,CHOP-ATF3 complex;GO:0005730,cellular_component,nucleolus;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:1903984,biological_process,positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1990440,biological_process,positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0034198,biological_process,cellular response to amino acid starvation","K09032,ko05166,HTLV-I infection"]
["HIP1",4.455858864,1.024748851,2.116274955,4.674063918,4.34E-10,{"v":4.35e-09,"d":"4.35E-09"},"ENSG00000127946","H2QUS3,Huntingtin interacting protein 1","XP_003318566.1,huntingtin-interacting protein 1 isoform X6","PF01608,I/LWEQ domain;PF16515,Clathrin-binding domain of Huntingtin-interacting protein 1;PF07651,ANTH domain","IPR035964,I/LWEQ domain superfamily;IPR008942,ENTH/VHS;IPR030224,Sla2 family;IPR011417,AP180 N-terminal homology (ANTH) domain;IPR032422,Huntingtin-interacting protein 1, clathrin-binding domain;IPR030554,Huntingtin-interacting protein 1;IPR013809,ENTH  domain;IPR002558,I/LWEQ domain","ENOG410XRXQ,-;KOG0980,Actin-binding protein SLA2/Huntingtin-interacting protein Hip1","GO:0006915,biological_process,apoptotic process;GO:0030136,cellular_component,clathrin-coated vesicle;GO:0005543,molecular_function,phospholipid binding;GO:0072583,biological_process,clathrin-dependent endocytosis;GO:0003779,molecular_function,actin binding;GO:0048268,biological_process,clathrin coat assembly;GO:0006897,biological_process,endocytosis;GO:0030276,molecular_function,clathrin binding;GO:0035091,molecular_function,phosphatidylinositol binding","K04559,ko05016,Huntington's disease"]
["CERS6-AS1",8.612830194,1.980760189,2.115955884,4.571039231,{"v":1.28e-09,"d":"1.28E-09"},{"v":1.15E-8,"d":"1.15E-08"},"-","-","-","-","-","-","-","-"]
["FAM210B",9.559480269,2.19846874,2.115583779,4.46002973,{"v":2.14e-09,"d":"2.14E-09"},{"v":1.83e-08,"d":"1.83E-08"},"ENSG00000124098","H2QKL9,Chromosome 20 open reading frame 108","XP_525363.1,protein FAM210B","PF06916,Protein of unknown function (DUF1279)","IPR009688,Domain of unknown function DUF1279","KOG4526,Predicted membrane protein;ENOG411243X,-","GO:0005741,cellular_component,mitochondrial outer membrane;GO:0071392,biological_process,cellular response to estradiol stimulus;GO:0031224,cellular_component,intrinsic component of membrane;GO:0016020,cellular_component,membrane;GO:0045648,biological_process,positive regulation of erythrocyte differentiation;GO:0016021,cellular_component,integral component of membrane","-"]
["KIF20A",43.07639826,9.934212585,2.115448947,6.72776463,{"v":2.24e-17,"d":"2.24E-17"},{"v":1.12e-15,"d":"1.12E-15"},"ENSG00000112984","H2QRK1,Kinesin-like protein","XP_001170694.1,kinesin-like protein KIF20A","PF00225,Kinesin motor domain","IPR019821,Kinesin motor domain, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001752,Kinesin motor domain;IPR027326,Kinesin-like protein KIF20A;IPR036961,Kinesin motor domain superfamily;IPR027640,Kinesin-like protein","KOG0247,Kinesin-like protein;COG5059,Kinesin-like protein","GO:0030496,cellular_component,midbody;GO:0005794,cellular_component,Golgi apparatus;GO:0019901,molecular_function,protein kinase binding;GO:0005871,cellular_component,kinesin complex;GO:0005874,cellular_component,microtubule;GO:0003777,molecular_function,microtubule motor activity;GO:0045171,cellular_component,intercellular bridge;GO:0008017,molecular_function,microtubule binding;GO:0005819,cellular_component,spindle;GO:0032154,cellular_component,cleavage furrow;GO:0003774,molecular_function,motor activity;GO:0000910,biological_process,cytokinesis;GO:0032465,biological_process,regulation of cytokinesis;GO:0016887,molecular_function,ATPase activity;GO:0000281,biological_process,mitotic cytokinesis;GO:0000920,biological_process,cell separation after cytokinesis;GO:0007018,biological_process,microtubule-based movement;GO:0001578,biological_process,microtubule bundle formation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0005654,cellular_component,nucleoplasm","-"]
["AKAP1",18.16466753,4.187586166,2.115255701,5.940123821,{"v":6.88e-15,"d":"6.88E-15"},{"v":2.06e-13,"d":"2.06E-13"},"ENSG00000121057","A0A140VK05,Testicular secretory protein Li 5","XP_005257766.1,-;NP_003479.1,A-kinase anchor protein 1, mitochondrial precursor;XP_016880680.1,-;NP_001229832.1,-;XP_005257764.1,-;XP_016880678.1,-;XP_016880679.1,-;NP_001229831.1,-","PF00013,KH domain;PF00567,Tudor domain","IPR004088,K Homology domain, type 1;IPR033104,A-kinase anchor protein 1, mitochondrial;IPR004087,K Homology domain;IPR035437,SNase-like, OB-fold superfamily;IPR002999,Tudor domain;IPR036612,K Homology domain, type 1 superfamily","-","GO:0034237,molecular_function,protein kinase A regulatory subunit binding;GO:0003676,molecular_function,nucleic acid binding;GO:0003723,molecular_function,RNA binding;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0010738,biological_process,regulation of protein kinase A signaling;GO:0016021,cellular_component,integral component of membrane","-"]
["SOX9",7.241478382,1.665379645,2.114617022,4.208280184,{"v":1.72e-08,"d":"1.72E-08"},{"v":1.2e-07,"d":"1.20E-07"},"ENSG00000125398","H2QDR6,Transcription factor SOX-9","-","PF12444,Sox developmental protein N terminal;PF00505,HMG (high mobility group) box","IPR029548,Transcription factor SOX-9;IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily;IPR022151,Sox developmental protein N-terminal","KOG0527,HMG-box transcription factor;ENOG410XT0K,-","GO:0007283,biological_process,spermatogenesis;GO:0034236,molecular_function,protein kinase A catalytic subunit binding;GO:0003179,biological_process,heart valve morphogenesis;GO:0003705,molecular_function,transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0046982,molecular_function,protein heterodimerization activity;GO:0060350,biological_process,endochondral bone morphogenesis;GO:0007417,biological_process,central nervous system development;GO:0071599,biological_process,otic vesicle development;GO:0005634,cellular_component,nucleus;GO:0072289,biological_process,metanephric nephron tubule formation;GO:0014032,biological_process,neural crest cell development;GO:0045732,biological_process,positive regulation of protein catabolic process;GO:0001501,biological_process,skeletal system development;GO:0060532,biological_process,bronchus cartilage development;GO:0060041,biological_process,retina development in camera-type eye;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0030198,biological_process,extracellular matrix organization;GO:2000794,biological_process,regulation of epithelial cell proliferation involved in lung morphogenesis;GO:0061036,biological_process,positive regulation of cartilage development;GO:1901203,biological_process,positive regulation of extracellular matrix assembly;GO:0071300,biological_process,cellular response to retinoic acid;GO:0032332,biological_process,positive regulation of chondrocyte differentiation;GO:0030879,biological_process,mammary gland development;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0044798,cellular_component,nuclear transcription factor complex;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0032808,biological_process,lacrimal gland development;GO:0003413,biological_process,chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0051216,biological_process,cartilage development;GO:0034504,biological_process,protein localization to nucleus;GO:0001942,biological_process,hair follicle development;GO:0060784,biological_process,regulation of cell proliferation involved in tissue homeostasis;GO:0060009,biological_process,Sertoli cell development;GO:0032991,cellular_component,protein-containing complex;GO:0098609,biological_process,cell-cell adhesion;GO:0008013,molecular_function,beta-catenin binding;GO:1902894,biological_process,negative regulation of pri-miRNA transcription by RNA polymerase II;GO:0071260,biological_process,cellular response to mechanical stimulus;GO:0030916,biological_process,otic vesicle formation;GO:0004672,molecular_function,protein kinase activity;GO:2000020,biological_process,positive regulation of male gonad development;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:0001837,biological_process,epithelial to mesenchymal transition;GO:0035326,molecular_function,enhancer binding;GO:0045165,biological_process,cell fate commitment;GO:2000138,biological_process,positive regulation of cell proliferation involved in heart morphogenesis;GO:0001502,biological_process,cartilage condensation;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0010629,biological_process,negative regulation of gene expression;GO:0048709,biological_process,oligodendrocyte differentiation;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:0003682,molecular_function,chromatin binding;GO:0060441,biological_process,epithelial tube branching involved in lung morphogenesis;GO:0001708,biological_process,cell fate specification;GO:0072189,biological_process,ureter development;GO:0010628,biological_process,positive regulation of gene expression;GO:0090103,biological_process,cochlea morphogenesis;GO:0002063,biological_process,chondrocyte development;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0035019,biological_process,somatic stem cell population maintenance;GO:0030155,biological_process,regulation of cell adhesion;GO:0072193,biological_process,ureter smooth muscle cell differentiation;GO:0019933,biological_process,cAMP-mediated signaling;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0050679,biological_process,positive regulation of epithelial cell proliferation;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0065003,biological_process,protein-containing complex assembly;GO:0001894,biological_process,tissue homeostasis;GO:0006334,biological_process,nucleosome assembly;GO:0003188,biological_process,heart valve formation;GO:0070168,biological_process,negative regulation of biomineral tissue development;GO:0030903,biological_process,notochord development;GO:0061145,biological_process,lung smooth muscle development;GO:0060729,biological_process,intestinal epithelial structure maintenance;GO:0030502,biological_process,negative regulation of bone mineralization;GO:0060487,biological_process,lung epithelial cell differentiation;GO:0030857,biological_process,negative regulation of epithelial cell differentiation;GO:0060534,biological_process,trachea cartilage development;GO:0002053,biological_process,positive regulation of mesenchymal cell proliferation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030850,biological_process,prostate gland development;GO:0001046,molecular_function,core promoter sequence-specific DNA binding;GO:0032331,biological_process,negative regulation of chondrocyte differentiation;GO:0072197,biological_process,ureter morphogenesis;GO:2001054,biological_process,negative regulation of mesenchymal cell apoptotic process;GO:0008584,biological_process,male gonad development;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0005654,cellular_component,nucleoplasm;GO:0060221,biological_process,retinal rod cell differentiation;GO:0042127,biological_process,regulation of cell proliferation;GO:0045662,biological_process,negative regulation of myoblast differentiation;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0097157,molecular_function,pre-mRNA intronic binding;GO:0007010,biological_process,cytoskeleton organization;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006338,biological_process,chromatin remodeling;GO:0002062,biological_process,chondrocyte differentiation;GO:0097065,biological_process,anterior head development;GO:0007165,biological_process,signal transduction;GO:0030154,biological_process,cell differentiation;GO:0001503,biological_process,ossification;GO:2000741,biological_process,positive regulation of mesenchymal stem cell differentiation;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0072034,biological_process,renal vesicle induction;GO:0072190,biological_process,ureter urothelium development;GO:0090184,biological_process,positive regulation of kidney development;GO:0002683,biological_process,negative regulation of immune system process;GO:0090190,biological_process,positive regulation of branching involved in ureteric bud morphogenesis;GO:0001934,biological_process,positive regulation of protein phosphorylation;GO:0030238,biological_process,male sex determination;GO:0070371,biological_process,ERK1 and ERK2 cascade;GO:0060174,biological_process,limb bud formation;GO:0001158,molecular_function,enhancer sequence-specific DNA binding;GO:0061046,biological_process,regulation of branching involved in lung morphogenesis;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0060512,biological_process,prostate gland morphogenesis;GO:0003170,biological_process,heart valve development;GO:0070384,biological_process,Harderian gland development;GO:0007507,biological_process,heart development;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0010564,biological_process,regulation of cell cycle process;GO:0071504,biological_process,cellular response to heparin;GO:0010634,biological_process,positive regulation of epithelial cell migration;GO:0001658,biological_process,branching involved in ureteric bud morphogenesis;GO:0035622,biological_process,intrahepatic bile duct development;GO:0030279,biological_process,negative regulation of ossification;GO:0003677,molecular_function,DNA binding;GO:0072170,biological_process,metanephric tubule development;GO:0061138,biological_process,morphogenesis of a branching epithelium;GO:0060018,biological_process,astrocyte fate commitment;GO:0045595,biological_process,regulation of cell differentiation;GO:0043491,biological_process,protein kinase B signaling;GO:0060008,biological_process,Sertoli cell differentiation;GO:0031018,biological_process,endocrine pancreas development;GO:0048873,biological_process,homeostasis of number of cells within a tissue;GO:0050680,biological_process,negative regulation of epithelial cell proliferation;GO:0019100,biological_process,male germ-line sex determination;GO:0071347,biological_process,cellular response to interleukin-1;GO:0003415,biological_process,chondrocyte hypertrophy;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0071560,biological_process,cellular response to transforming growth factor beta stimulus;GO:0003203,biological_process,endocardial cushion morphogenesis;GO:0007219,biological_process,Notch signaling pathway;GO:0030858,biological_process,positive regulation of epithelial cell differentiation;GO:0046533,biological_process,negative regulation of photoreceptor cell differentiation;GO:0060517,biological_process,epithelial cell proliferation involved in prostatic bud elongation","-"]
["UBAP1",29.72535008,6.855872949,2.114273449,5.693496574,{"v":6.29e-14,"d":"6.29E-14"},{"v":1.49e-12,"d":"1.49E-12"},"ENSG00000165006","H2R2H2,Uncharacterized protein","XP_016816244.1,-","-","IPR023340,UMA domain;IPR015940,Ubiquitin-associated domain;IPR009060,UBA-like superfamily","ENOG410ZK9H,-;ENOG410IG52,-","GO:0005794,cellular_component,Golgi apparatus;GO:0005737,cellular_component,cytoplasm;GO:0000813,cellular_component,ESCRT I complex;GO:0043162,biological_process,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0005886,cellular_component,plasma membrane;GO:0043130,molecular_function,ubiquitin binding;GO:0005829,cellular_component,cytosol","-"]
["RP11-843P14.2",50.88431685,11.7022659,2.113973093,4.063558162,{"v":6.74e-08,"d":"6.74E-08"},{"v":4.11e-07,"d":"4.11E-07"},"ENSG00000250909","A0A1D5QAK4,KIAA1191","XP_014996929.1,-;NP_001253349.1,putative monooxygenase p33MONOX","-","IPR026759,Putative monooxygenase p33MONOX","ENOG410IH5Y,-;ENOG410YBU1,-","-","-"]
["RBMXL1",4.761339654,1.095002667,2.113594526,3.985296331,{"v":1.83e-07,"d":"1.83E-07"},{"v":1.02E-6,"d":"1.02E-06"},"ENSG00000213516","Q2VIN3,RBM1","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF08081,RBM1CTR (NUC064) family","IPR012604,RBM1CTR;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR003954,RNA recognition motif domain, eukaryote","ENOG4111GI6,-;ENOG410IHG3,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["ATE1",4.234429164,0.973824924,2.113594526,3.985296331,{"v":1.83e-07,"d":"1.83E-07"},{"v":1.02E-6,"d":"1.02E-06"},"ENSG00000107669","H2Q2P4,Arginyl-tRNA--protein transferase 1","-","PF04377,Arginine-tRNA-protein transferase, C terminus;PF04376,Arginine-tRNA-protein transferase, N terminus","IPR017137,Arginine-tRNA-protein transferase 1, eukaryotic;IPR016181,Acyl-CoA N-acyltransferase;IPR030700,N-end rule aminoacyl transferase;IPR007472,N-end rule aminoacyl transferase, C-terminal;IPR007471,N-end aminoacyl transferase, N-terminal","COG2935,Putative arginyl-tRNA:protein arginylyltransferase;KOG1193,Arginyl-tRNA-protein transferase","GO:0005737,cellular_component,cytoplasm;GO:0004057,molecular_function,arginyltransferase activity;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016740,molecular_function,transferase activity;GO:0016598,biological_process,protein arginylation","-"]
["SEC24A",3.363551565,0.773542364,2.113594526,3.985296331,{"v":1.83e-07,"d":"1.83E-07"},{"v":1.02E-6,"d":"1.02E-06"},"ENSG00000113615","G3R641,SEC24 homolog A, COPII coat complex component","XP_004042570.1,protein transport protein Sec24A isoform X1","PF04815,Sec23/Sec24 helical domain;PF04811,Sec23/Sec24 trunk domain;PF08033,Sec23/Sec24 beta-sandwich domain;PF00626,elsolin repeat;PF04810,Sec23/Sec24 zinc finger","IPR007123,Gelsolin-like domain;IPR036180,Gelsolin-like domain superfamily;IPR036465,von Willebrand factor A-like domain superfamily;IPR006900,Sec23/Sec24, helical domain;IPR029006,ADF-H/Gelsolin-like domain superfamily;IPR006895,Zinc finger, Sec23/Sec24-type;IPR036175,Sec23/Sec24 helical domain superfamily;IPR006896,Sec23/Sec24, trunk domain;IPR012990,Sec23/Sec24 beta-sandwich","-","GO:0015031,biological_process,protein transport;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0000139,cellular_component,Golgi membrane;GO:0030127,cellular_component,COPII vesicle coat;GO:0090110,biological_process,cargo loading into COPII-coated vesicle;GO:0008270,molecular_function,zinc ion binding;GO:0006886,biological_process,intracellular protein transport","K14007,ko04141,Protein processing in endoplasmic reticulum"]
["SOX7",7.531385205,1.732051793,2.113594526,3.985296331,{"v":1.83e-07,"d":"1.83E-07"},{"v":1.02E-6,"d":"1.02E-06"},"ENSG00000171056","Q53ER5,SRY-box 7 variant","-","PF00505,HMG (high mobility group) box;PF12067,Sox 17/18 central domain","IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily;IPR033392,Sox 7/17/18, central domain;IPR021934,Sox, C-terminal","ENOG410IPZD,-;ENOG410XP3W,-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["ARHGEF11",13.00061131,3.002056145,2.113136301,6.183443752,1.24E-15,{"v":4.43e-14,"d":"4.43E-14"},"ENSG00000132694","H2R0Q2,Rho guanine nucleotide exchange factor","XP_001167782.1,rho guanine nucleotide exchange factor 11 isoform X16","PF00621,RhoGEF domain;PF00595,PDZ domain (Also known as DHR or GLGF);PF09128,Regulator of G protein signalling-like domain","IPR032919,Rho guanine nucleotide exchange factor 11;IPR036034,PDZ superfamily;IPR036305,RGS domain superfamily;IPR015212,Regulator of G protein signalling-like domain;IPR001478,PDZ domain;IPR037889,Rho guanine nucleotide exchange factor 11, RGS domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR037803,Rho guanine nucleotide exchange factor 11, PH domain;IPR035899,Dbl homology (DH) domain superfamily;IPR000219,Dbl homology (DH) domain;IPR016137,RGS domain","COG5422,RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases;KOG3520,Predicted guanine nucleotide exchange factor","GO:0001664,molecular_function,G-protein coupled receptor binding;GO:0005737,cellular_component,cytoplasm;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0007266,biological_process,Rho protein signal transduction;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","K12331,ko05200,Pathways in cancer;K12331,ko04270,Vascular smooth muscle contraction"]
["OCLN",9.658562336,2.229332713,2.112665905,5.365308476,{"v":1.21e-12,"d":"1.21E-12"},{"v":2.16e-11,"d":"2.16E-11"},"ENSG00000197822","H2RAY7,Occludin","XP_009447329.1,-;XP_001158455.1,-;XP_001158401.1,occludin isoform X1","PF01284,Membrane-associating domain;PF07303,Occludin homology domain","IPR036259,MFS transporter superfamily;IPR031176,ELL/occludin family;IPR002958,Occludin;IPR010844,Occludin homology domain;IPR008253,Marvel domain","ENOG410IGK8,-;ENOG4110E0E,-","GO:0070830,biological_process,bicellular tight junction assembly;GO:0030054,cellular_component,cell junction;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0005923,cellular_component,bicellular tight junction;GO:0045216,biological_process,cell-cell junction organization;GO:0005911,cellular_component,cell-cell junction;GO:0019904,molecular_function,protein domain specific binding;GO:0016324,cellular_component,apical plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016327,cellular_component,apicolateral plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0030139,cellular_component,endocytic vesicle","K06088,ko05160,Hepatitis C;K06088,ko04670,Leukocyte transendothelial migration;K06088,ko04530,Tight junction;K06088,ko04514,Cell adhesion molecules (CAMs);K06088,ko05130,Pathogenic Escherichia coli infection"]
["ETV5",33.96965194,7.849917074,2.112659159,6.935494153,{"v":5.31e-18,"d":"5.31E-18"},{"v":3.01e-16,"d":"3.01E-16"},"ENSG00000244405","G1R425,ETS variant 5","XP_003256647.1,ETS translocation variant 5 isoform X2;XP_012366230.1,-","PF04621,PEA3 subfamily ETS-domain transcription factor N terminal domain;PF00178,ts-domain","IPR006715,PEA3-type ETS-domain transcription factor, N-terminal;IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000418,Ets domain","KOG3806,Predicted transcription factor;ENOG410Z0ZF,-","GO:0060762,biological_process,regulation of branching involved in mammary gland duct morphogenesis;GO:0071340,biological_process,skeletal muscle acetylcholine-gated channel clustering;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0050807,biological_process,regulation of synapse organization;GO:0005886,cellular_component,plasma membrane;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0007626,biological_process,locomotory behavior;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0005654,cellular_component,nucleoplasm;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0034599,biological_process,cellular response to oxidative stress;GO:0007274,biological_process,neuromuscular synaptic transmission","-"]
["USP3-AS1",5.504043103,1.265808011,2.112135827,3.720873639,{"v":9.24e-07,"d":"9.24E-07"},{"v":4.39e-06,"d":"4.39E-06"},"ENSG00000259248","A0A091WRR6,Ubiquitinyl hydrolase 1","-","PF02148,Zn-finger in ubiquitin-hydrolases and other protein;PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR001607,Zinc finger, UBP-type;IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase;IPR013083,Zinc finger, RING/FYVE/PHD-type","-","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function,metal ion binding;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0008270,molecular_function,zinc ion binding;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0016579,biological_process,protein deubiquitination;GO:0008233,molecular_function,peptidase activity","-"]
["ATP11A",10.21910332,2.362097216,2.111952147,6.4505858,{"v":1.63e-16,"d":"1.63E-16"},6.87E-15,"ENSG00000068650","E9PEJ6,Phospholipid-transporting ATPase","NP_115565.3,probable phospholipid-transporting ATPase IH isoform b","PF13246,Cation transport ATPase (P-type);PF16209,Phospholipid-translocating ATPase N-terminal;PF00122,1-E2 ATPase;PF16212,Phospholipid-translocating P-type ATPase C-terminal","IPR032630,P-type ATPase, C-terminal;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR023299,P-type ATPase, cytoplasmic domain N;IPR018303,P-type ATPase, phosphorylation site;IPR006539,P-type ATPase, subfamily IV;IPR023298,P-type ATPase, transmembrane domain superfamily;IPR032631,P-type ATPase, N-terminal;IPR008250,P-type ATPase, A domain superfamily;IPR001757,P-type ATPase;IPR030361,Probable phospholipid-transporting ATPase IH","COG0474,Cation transport ATPase;KOG0206,P-type ATPase","GO:0016787,molecular_function,hydrolase activity;GO:0045332,biological_process,phospholipid translocation;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0000287,molecular_function,magnesium ion binding;GO:0016020,cellular_component,membrane;GO:0015914,biological_process,phospholipid transport;GO:0004012,molecular_function,phospholipid-translocating ATPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","-"]
["HID1",9.159615029,2.115322434,2.111500263,5.168063942,{"v":8.04e-12,"d":"8.04E-12"},{"v":1.18e-10,"d":"1.18E-10"},"ENSG00000167861","H2QDU0,Uncharacterized protein","XP_511668.3,protein HID1 isoform X1","PF12722,High-temperature-induced dauer-formation protein","IPR026705,Hid-1/Ecm30","KOG2226,Proteins containing regions of low-complexity;ENOG410XPB2,-","GO:0031001,biological_process,response to brefeldin A;GO:0005737,cellular_component,cytoplasm;GO:0005794,cellular_component,Golgi apparatus;GO:0090498,cellular_component,extrinsic component of Golgi membrane;GO:0016020,cellular_component,membrane;GO:0000138,cellular_component,Golgi trans cisterna;GO:0005829,cellular_component,cytosol;GO:0005881,cellular_component,cytoplasmic microtubule;GO:0005797,cellular_component,Golgi medial cisterna;GO:0006886,biological_process,intracellular protein transport","-"]
["ZNF845",3.874264777,0.890995092,2.110760333,3.51263352,{"v":2.37e-06,"d":"2.37E-06"},{"v":1.04E-5,"d":"1.04E-05"},"ENSG00000213799","H2RBR4,Zinc finger protein 845","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["EDEM2",8.909395758,2.0489637,2.110760333,3.51263352,{"v":2.37e-06,"d":"2.37E-06"},{"v":1.04E-5,"d":"1.04E-05"},"ENSG00000088298","H2QK90,alpha-1,2-Mannosidase","XP_514601.1,ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1","PF01532,lycosyl hydrolase family 47","IPR012341,Six-hairpin glycosidase-like superfamily;IPR036026,Seven-hairpin glycosidases;IPR001382,Glycoside hydrolase family 47","ENOG410XS6F,-;KOG2429,Glycosyl hydrolase, family 47","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0016787,molecular_function,hydrolase activity;GO:0036509,biological_process,trimming of terminal mannose on B branch;GO:0004571,molecular_function,mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:1904154,biological_process,positive regulation of retrograde protein transport, ER to cytosol;GO:0003824,molecular_function,catalytic activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0006491,biological_process,N-glycan processing;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0044322,cellular_component,endoplasmic reticulum quality control compartment;GO:0005509,molecular_function,calcium ion binding;GO:0097466,biological_process,ubiquitin-dependent glycoprotein ERAD pathway;GO:1904382,biological_process,mannose trimming involved in glycoprotein ERAD pathway","-"]
["PTPRJ",8.688770389,2.009578301,2.110286812,5.71446544,{"v":4.78e-14,"d":"4.78E-14"},{"v":1.16e-12,"d":"1.16E-12"},"ENSG00000149177","A0A087WVC6,Receptor-type tyrosine-protein phosphatase eta","-","PF00102,Protein-tyrosine phosphatase;PF00041,ibronectin type III domain","IPR003961,Fibronectin type III;IPR029021,Protein-tyrosine phosphatase-like;IPR016130,Protein-tyrosine phosphatase, active site;IPR000242,PTP type protein phosphatase;IPR036116,Fibronectin type III superfamily;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR013783,Immunoglobulin-like fold;IPR000387,Tyrosine specific protein phosphatases domain","KOG0791,Protein tyrosine phosphatase, contains fn3 domain;COG5599,Protein tyrosine phosphatase","GO:0016787,molecular_function,hydrolase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0006470,biological_process,protein dephosphorylation;GO:0016020,cellular_component,membrane;GO:0016311,biological_process,dephosphorylation;GO:0016021,cellular_component,integral component of membrane;GO:0016791,molecular_function,phosphatase activity","-"]
["RP11-4K16.2",99.05928173,22.92562718,2.11023278,6.546569913,{"v":7.79e-17,"d":"7.79E-17"},{"v":3.48e-15,"d":"3.48E-15"},"-","-","-","-","-","-","-","-"]
["VPS45",7.925450394,1.831399006,2.110223441,4.980111688,{"v":2.67e-11,"d":"2.67E-11"},{"v":3.5e-10,"d":"3.50E-10"},"ENSG00000136631","H2PZW0,Vacuolar protein sorting 45 homolog","XP_001167625.1,vacuolar protein sorting-associated protein 45 isoform X1","PF00995,Sec1 family","IPR027482,Sec1-like, domain 2;IPR036045,Sec1-like superfamily;IPR001619,Sec1-like protein","KOG1299,Vacuolar sorting protein VPS45/Stt10 (Sec1 family);COG5158,Proteins involved in synaptic transmission and general secretion, Sec1 family","GO:0016192,biological_process,vesicle-mediated transport;GO:0006904,biological_process,vesicle docking involved in exocytosis","-"]
["EPN3",10.69133356,2.470534377,2.110223441,4.980111688,{"v":2.67e-11,"d":"2.67E-11"},{"v":3.5e-10,"d":"3.50E-10"},"ENSG00000049283","H2NTN0,Epsin 3","XP_002827422.1,epsin-3","PF02809,Ubiquitin interaction motif;PF01417,NTH domain","IPR027318,Epsin-3, metazoa;IPR013809,ENTH  domain;IPR003903,Ubiquitin interacting motif;IPR008942,ENTH/VHS","ENOG410XSM0,-;KOG2056,Equilibrative nucleoside transporter protein","GO:1990175,molecular_function,EH domain binding;GO:0005905,cellular_component,clathrin-coated pit;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0019897,cellular_component,extrinsic component of plasma membrane;GO:0005634,cellular_component,nucleus;GO:0030136,cellular_component,clathrin-coated vesicle;GO:0005654,cellular_component,nucleoplasm","K12471,ko04144,Endocytosis"]
["CIDEB",4.90067842,1.127047497,2.109886111,3.395818495,{"v":8.07e-06,"d":"8.07E-06"},{"v":3.13e-05,"d":"3.13E-05"},"ENSG00000136305","G3QPU6,Cell death-inducing DFFA-like effector b","XP_018864837.1,-","PF02017,CIDE-N domain","IPR003508,CIDE-N domain","-","GO:0006915,biological_process,apoptotic process;GO:0005622,cellular_component,intracellular","-"]
["EXOSC10",28.52053386,6.604577187,2.109500938,6.734813481,{"v":2.33e-17,"d":"2.33E-17"},{"v":1.16e-15,"d":"1.16E-15"},"ENSG00000171824","K7DMN5,Exosome component 10","-","PF08066,PMC2NT (NUC016) domain;PF01612,3'-5' exonuclease;PF00570,HRDC domain","IPR012588,Exosome-associated factor Rrp6, N-terminal;IPR012337,Ribonuclease H-like superfamily;IPR010997,HRDC-like superfamily;IPR002121,HRDC domain;IPR002562,3'-5' exonuclease domain","COG0349,Ribonuclease D;KOG2206,Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6)","GO:0008408,molecular_function,3'-5' exonuclease activity;GO:0000176,cellular_component,nuclear exosome (RNase complex);GO:0044237,biological_process,cellular metabolic process;GO:0005622,cellular_component,intracellular;GO:0003824,molecular_function,catalytic activity;GO:0006396,biological_process,RNA processing;GO:0003676,molecular_function,nucleic acid binding;GO:0000166,molecular_function,nucleotide binding;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0006139,biological_process,nucleobase-containing compound metabolic process","-"]
["GTSF1",17.9694484,4.154211665,2.10926571,4.854274407,1.06E-10,{"v":1.2E-9,"d":"1.20E-09"},"ENSG00000170627","H2RG03,Uncharacterized protein","-","PF05253,U11-48K-like CHHC zinc finger","IPR022776,TRM13/UPF0224 family, U11-48K-like CHHC zinc finger domain;IPR036236,Zinc finger C2H2 superfamily;IPR007917,Gametocyte-specific factor 1, vertebrate","ENOG4111W8D,-;KOG4376,Uncharacterized conserved protein","GO:0007283,biological_process,spermatogenesis","-"]
["PRPF8",30.7621201,7.12750955,2.109213679,7.75631889,7.18E-20,{"v":5.75e-18,"d":"5.75E-18"},"ENSG00000174231","H0VGR9,Pre-mRNA processing factor 8","XP_005003606.1,-;XP_003469727.1,-","PF10596,U6-snRNA interacting domain of PrP8;PF12134,PRP8 domain IV core;PF08084,PROCT (NUC072) domain;PF10597,U5-snRNA binding site 2 of PrP8;PF08082,PRO8NT (NUC069), PrP8 N-terminal domain;PF01398,JAB1/Mov34/MPN/PAD-1 ubiquitin protease;PF10598,RNA recognition motif of the spliceosomal PrP8;PF08083,PROCN (NUC071) domain","IPR019581,Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding;IPR027652,Pre-mRNA-processing-splicing factor 8;IPR037518,MPN domain;IPR012592,PROCN domain;IPR021983,PRP8 domain IV core;IPR000555,JAB1/MPN/MOV34 metalloenzyme domain;IPR012984,PROCT domain;IPR012591,PRO8NT domain;IPR019580,Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding;IPR019582,RNA recognition motif, spliceosomal PrP8;IPR012337,Ribonuclease H-like superfamily","COG5178,U5 snRNP spliceosome subunit;KOG1795,U5 snRNP spliceosome subunit","GO:0070530,molecular_function,K63-linked polyubiquitin modification-dependent protein binding;GO:0071007,cellular_component,U2-type catalytic step 2 spliceosome;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0003723,molecular_function,RNA binding;GO:0005681,cellular_component,spliceosomal complex;GO:0017070,molecular_function,U6 snRNA binding;GO:0071013,cellular_component,catalytic step 2 spliceosome;GO:0000244,biological_process,spliceosomal tri-snRNP complex assembly;GO:0030623,molecular_function,U5 snRNA binding;GO:0046540,cellular_component,U4/U6 x U5 tri-snRNP complex;GO:0005634,cellular_component,nucleus","-"]
["KDM4A-AS1",7.378357699,1.696858856,2.108838165,3.26850931,{"v":2.05E-5,"d":"2.05E-05"},{"v":7.29e-05,"d":"7.29E-05"},"-","-","-","-","-","-","-","-"]
["LRRC8E",3.291200905,0.756903315,2.108838165,3.26850931,{"v":2.05E-5,"d":"2.05E-05"},{"v":7.29e-05,"d":"7.29E-05"},"ENSG00000171017","G3S403,Leucine rich repeat containing 8 family member E","XP_004059950.1,-;XP_004059949.1,volume-regulated anion channel subunit LRRC8E isoform X1","PF13855,Leucine rich repeat;PF12534,Pannexin-like TM region of LRRC8","IPR001611,Leucine-rich repeat;IPR021040,LRRC8, pannexin-like TM region;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","-","GO:0005225,molecular_function,volume-sensitive anion channel activity;GO:0005737,cellular_component,cytoplasm;GO:0098656,biological_process,anion transmembrane transport;GO:0015698,biological_process,inorganic anion transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["DOPEY2",1.577808274,0.362860958,2.108838165,3.26850931,{"v":2.05E-5,"d":"2.05E-05"},{"v":7.29e-05,"d":"7.29E-05"},"ENSG00000142197","H2QL00,Dopey family member 2","XP_531552.3,protein dopey-2 isoform X1","PF04118,opey, N-terminal","IPR007249,Dopey, N-terminal","KOG3613,Dopey and related predicted leucine zipper transcription factors;COG5221,Dopey and related predicted leucine zipper transcription factors","GO:0005802,cellular_component,trans-Golgi network;GO:0005829,cellular_component,cytosol;GO:0006895,biological_process,Golgi to endosome transport;GO:0005768,cellular_component,endosome;GO:0050890,biological_process,cognition","-"]
["A4GALT",4.841185429,1.113365427,2.108838165,3.26850931,{"v":2.05E-5,"d":"2.05E-05"},{"v":7.29e-05,"d":"7.29E-05"},"ENSG00000128274","A0A0S2Z5J1,Alpha 14-galactosyltransferase isoform 1","XP_005261701.1,-;XP_011528535.1,-;NP_059132.1,lactosylceramide 4-alpha-galactosyltransferase;NP_001304967.1,-;XP_006724329.1,-;XP_005261703.1,-;XP_006724328.1,-;XP_016884320.1,-;XP_005261705.1,-;XP_005261704.1,-","PF04572,Alpha 1,4-glycosyltransferase conserved region;PF04488,lycosyltransferase sugar-binding region containing DXD motif","IPR007577,Glycosyltransferase, DXD sugar-binding motif;IPR029044,Nucleotide-diphospho-sugar transferases;IPR007652,Alpha 1,4-glycosyltransferase domain","-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0008378,molecular_function,galactosyltransferase activity;GO:0015643,molecular_function,toxic substance binding;GO:0050512,molecular_function,lactosylceramide 4-alpha-galactosyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0001576,biological_process,globoside biosynthetic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K01988,ko00603,Glycosphingolipid biosynthesis - globo series"]
["NAA25",4.056141897,0.938214841,2.108109696,4.716334612,{"v":2.58e-10,"d":"2.58E-10"},{"v":2.7e-09,"d":"2.70E-09"},"ENSG00000111300","G3QW63,N","XP_018894656.1,N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X1","PF09797,N-acetyltransferase B complex (NatB) non catalytic subunit","IPR019183,N-acetyltransferase B complex, non-catalytic subunit;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR013026,Tetratricopeptide repeat-containing domain","-","GO:0005829,cellular_component,cytosol;GO:0005794,cellular_component,Golgi apparatus","-"]
["ZCCHC2",3.874532903,0.896392424,2.107669271,4.667240657,{"v":5.44e-10,"d":"5.44E-10"},{"v":5.34e-09,"d":"5.34E-09"},"ENSG00000141664","H2QEM6,Uncharacterized protein","XP_003315969.2,zinc finger CCHC domain-containing protein 2 isoform X1","PF00098,Zinc knuckle","IPR036871,PX domain superfamily;IPR001878,Zinc finger, CCHC-type;IPR036875,Zinc finger, CCHC-type superfamily","ENOG4111U3M,-;ENOG410IZZC,-","GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0008270,molecular_function,zinc ion binding","-"]
["GRHL2",50.35252256,11.67909309,2.107597078,7.562617941,{"v":2.1e-19,"d":"2.10E-19"},{"v":1.58e-17,"d":"1.58E-17"},"ENSG00000083307","H2QWI7,Uncharacterized protein","XP_519890.3,-","PF04516,CP2 transcription factor","IPR007604,CP2 transcription factor","KOG4091,Transcription factor;ENOG410XNZ6,-","GO:0060324,biological_process,face development;GO:0030323,biological_process,respiratory tube development;GO:0060487,biological_process,lung epithelial cell differentiation;GO:0045617,biological_process,negative regulation of keratinocyte differentiation;GO:0035264,biological_process,multicellular organism growth;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0060672,biological_process,epithelial cell morphogenesis involved in placental branching;GO:0003208,biological_process,cardiac ventricle morphogenesis;GO:0005634,cellular_component,nucleus;GO:0001701,biological_process,in utero embryonic development;GO:0007155,biological_process,cell adhesion;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0034329,biological_process,cell junction assembly;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0060463,biological_process,lung lobe morphogenesis;GO:0001843,biological_process,neural tube closure;GO:0003682,molecular_function,chromatin binding;GO:0001161,molecular_function,intronic transcription regulatory region sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0008544,biological_process,epidermis development;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0031490,molecular_function,chromatin DNA binding;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0090132,biological_process,epithelium migration;GO:0042733,biological_process,embryonic digit morphogenesis;GO:0007420,biological_process,brain development;GO:0010468,biological_process,regulation of gene expression;GO:0021915,biological_process,neural tube development;GO:0005654,cellular_component,nucleoplasm;GO:0070830,biological_process,bicellular tight junction assembly;GO:0005911,cellular_component,cell-cell junction;GO:0043010,biological_process,camera-type eye development;GO:0008283,biological_process,cell proliferation;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0048568,biological_process,embryonic organ development;GO:0048701,biological_process,embryonic cranial skeleton morphogenesis;GO:0044030,biological_process,regulation of DNA methylation;GO:0003382,biological_process,epithelial cell morphogenesis;GO:0051973,biological_process,positive regulation of telomerase activity","-"]
["RP11-59C5.3",2.362352219,0.543288689,2.107558998,3.128613695,{"v":5.42e-05,"d":"5.42E-05"},0.000174092,"ENSG00000273599","A0A0S7JYP6,CTBP2","-","PF00389,-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain;PF02826,-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain","IPR036291,NAD(P)-binding domain superfamily;IPR029753,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site;IPR006140,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain;IPR006139,D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain","-","GO:0051287,molecular_function,NAD binding;GO:0016616,molecular_function,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016491,molecular_function,oxidoreductase activity;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process","-"]
["RP11-566K11.5",6.748867287,1.552090003,2.107558998,3.128613695,{"v":5.42e-05,"d":"5.42E-05"},0.000174092,"ENSG00000261317","G9L5E1,Tigger transposable element-derived protein 1-like protein","-","PF03184,superfamily endonuclease","IPR004875,DDE superfamily endonuclease domain","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["CAPN12",2.149320792,0.494296179,2.107558998,3.128613695,{"v":5.42e-05,"d":"5.42E-05"},0.000174092,"ENSG00000182472","H2NYP7,Calpain 12","-","PF00648,Calpain family cysteine protease;PF01067,Calpain large subunit, domain III","IPR018247,EF-Hand 1, calcium-binding site;IPR000169,Cysteine peptidase, cysteine active site;IPR001300,Peptidase C2, calpain, catalytic domain;IPR022684,Peptidase C2, calpain family;IPR022683,Peptidase C2, calpain, domain III;IPR036213,Calpain large subunit, domain III superfamily;IPR002048,EF-hand domain;IPR022682,Peptidase C2, calpain, large subunit, domain III;IPR033883,Calpain subdomain III;IPR011992,EF-hand domain pair;IPR029545,Calpain-12","KOG0045,Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily);ENOG410XP0B,-","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0005509,molecular_function,calcium ion binding;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0005622,cellular_component,intracellular;GO:0004198,molecular_function,calcium-dependent cysteine-type endopeptidase activity;GO:0008233,molecular_function,peptidase activity","-"]
["AAR2",4.135068638,0.950974204,2.107558998,3.128613695,{"v":5.42e-05,"d":"5.42E-05"},0.000174092,"ENSG00000131043","A2A2Q9,Protein AAR2 homolog","-","PF05282,AAR2 protein","IPR038514,AAR2, C-terminal domain superfamily;IPR033647,AAR2, N-terminal;IPR033648,AAR2, C-terminal;IPR007946,A1 cistron-splicing factor, AAR2;IPR038516,AAR2, N-terminal domain superfamily","ENOG410XSI4,-;KOG3937,mRNA splicing factor","-","-"]
["XXbac-BPG246D15.9",4.740424342,1.090192608,2.107558998,3.128613695,{"v":5.42e-05,"d":"5.42E-05"},0.000174092,"ENSG00000250264","E7ENX8,Uncharacterized protein","-","PF07654,Immunoglobulin C1-set domain;PF00005,ABC transporter;PF00664,ABC transporter transmembrane region;PF00969,Class II histocompatibility antigen, beta domain","IPR000353,MHC class II, beta chain, N-terminal;IPR011527,ABC transporter type 1, transmembrane domain;IPR005293,Antigen peptide transporter 2;IPR003006,Immunoglobulin/major histocompatibility complex, conserved site;IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR017871,ABC transporter, conserved site;IPR003593,AAA+ ATPase domain;IPR036640,ABC transporter type 1, transmembrane domain superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR014745,MHC class II, alpha/beta chain, N-terminal;IPR013305,ABC transporter Tap-like;IPR007110,Immunoglobulin-like domain;IPR003597,Immunoglobulin C1-set;IPR011162,MHC classes I/II-like antigen recognition protein","KOG0058,Peptide exporter, ABC superfamily;COG1132,ABC-type multidrug transport system, ATPase and permease components","GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0015440,molecular_function,peptide-transporting ATPase activity;GO:0015197,-,-;GO:0019885,biological_process,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0042287,molecular_function,MHC protein binding;GO:0019882,biological_process,antigen processing and presentation;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0000166,molecular_function,nucleotide binding;GO:0005783,cellular_component,endoplasmic reticulum;GO:0015833,biological_process,peptide transport;GO:0006955,biological_process,immune response;GO:0055085,biological_process,transmembrane transport;GO:0042613,cellular_component,MHC class II protein complex;GO:0016887,molecular_function,ATPase activity;GO:0042825,cellular_component,TAP complex;GO:0016607,cellular_component,nuclear speck;GO:0016020,cellular_component,membrane;GO:0002504,biological_process,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0002376,biological_process,immune system process;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","-"]
["ACACA",5.001851154,1.158711445,2.107412953,5.361110107,1.43E-12,{"v":2.5e-11,"d":"2.50E-11"},"ENSG00000278540","K6ZH78,Acetyl-CoA carboxylase alpha","-","PF02785,Biotin carboxylase C-terminal domain;PF01039,Carboxyl transferase domain;PF00364,Biotin-requiring enzyme;PF02786,Carbamoyl-phosphate synthase L chain, ATP binding domain;PF00289,Biotin carboxylase, N-terminal domain;PF08326,Acetyl-CoA carboxylase, central region","IPR013537,Acetyl-CoA carboxylase, central domain;IPR011053,Single hybrid motif;IPR034733,Acetyl-CoA carboxylase;IPR013815,ATP-grasp fold, subdomain 1;IPR005479,Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain;IPR011761,ATP-grasp fold;IPR005482,Biotin carboxylase, C-terminal;IPR011763,Acetyl-coenzyme A carboxyltransferase, C-terminal;IPR000089,Biotin/lipoyl attachment;IPR029045,ClpP/crotonase-like domain superfamily;IPR011762,Acetyl-coenzyme A carboxyltransferase, N-terminal;IPR001882,Biotin-binding site;IPR016185,Pre-ATP-grasp domain superfamily;IPR011054,Rudiment single hybrid motif;IPR005481,Biotin carboxylase-like, N-terminal domain;IPR011764,Biotin carboxylation domain","COG0439,Biotin carboxylase;COG4799,Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta);COG0511,Biotin carboxyl carrier protein;KOG0368,Acetyl-CoA carboxylase","GO:0003989,molecular_function,acetyl-CoA carboxylase activity;GO:0046872,molecular_function,metal ion binding;GO:0006633,biological_process,fatty acid biosynthetic process;GO:0016874,molecular_function,ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["ARHGDIB",441.3685954,102.4143118,2.107389513,9.161438334,{"v":9.5e-22,"d":"9.50E-22"},1.04E-19,"ENSG00000111348","H2Q5I9,Rho GDP dissociation inhibitor","XP_009423190.1,-;XP_009423189.1,-","PF02115,RHO protein GDP dissociation inhibitor","IPR000406,Rho protein GDP-dissociation inhibitor;IPR024792,Rho GDP-dissociation inhibitor domain superfamily;IPR014756,Immunoglobulin E-set","KOG3205,Rho GDP-dissociation inhibitor;ENOG4111K44,-","GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005737,cellular_component,cytoplasm;GO:2000249,biological_process,regulation of actin cytoskeleton reorganization;GO:0048365,molecular_function,Rac GTPase binding;GO:0050790,biological_process,regulation of catalytic activity;GO:0003924,molecular_function,GTPase activity;GO:0005829,cellular_component,cytosol;GO:0005094,molecular_function,Rho GDP-dissociation inhibitor activity;GO:1901164,biological_process,negative regulation of trophoblast cell migration","K12462,ko04722,Neurotrophin signaling pathway;K12462,ko04962,Vasopressin-regulated water reabsorption"]
["NCDN",7.485524206,1.732611261,2.106686711,4.563701635,{"v":1.61E-9,"d":"1.61E-09"},{"v":1.42E-8,"d":"1.42E-08"},"ENSG00000020129","H2R2Y1,Neurochondrin","XP_003308021.1,-","PF05536,Neurochondrin","IPR016024,Armadillo-type fold;IPR008709,Neurochondrin","KOG2611,Neurochondrin/leucine-rich protein (Neurochondrin);ENOG410XRYT,-","GO:0045453,biological_process,bone resorption;GO:0031175,biological_process,neuron projection development;GO:0043005,cellular_component,neuron projection;GO:0005829,cellular_component,cytosol","-"]
["RP11-223P11.2",47.17541553,10.92211484,2.106136432,4.508984474,{"v":1.53e-09,"d":"1.53E-09"},{"v":1.35E-8,"d":"1.35E-08"},"ENSG00000232935","V8P237,Uncharacterized protein","-","PF14429,C2 domain in Dock180 and Zizimin proteins","IPR026791,Dedicator of cytokinesis;IPR030717,Dedicator of cytokinesis protein 1;IPR027007,DHR-1 domain;IPR035892,C2 domain superfamily","-","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function,GTPase activator activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0065009,biological_process,regulation of molecular function;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005622,cellular_component,intracellular;GO:0007010,biological_process,cytoskeleton organization;GO:0016477,biological_process,cell migration","-"]
["RP11-44M6.7",8.039436866,1.861301097,2.106136432,4.508984474,{"v":1.53e-09,"d":"1.53E-09"},{"v":1.35E-8,"d":"1.35E-08"},"ENSG00000274272","H2PLN6,Uncharacterized protein","-","PF15476,Histone deacetylase complex subunit SAP25","IPR029163,Histone deacetylase complex subunit SAP25","ENOG4111EFG,-;ENOG410IXUR,-","GO:0005737,cellular_component,cytoplasm;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["POGK",12.53636657,2.908943937,2.1060014,6.050968622,{"v":3.45e-15,"d":"3.45E-15"},{"v":1.1E-13,"d":"1.10E-13"},"ENSG00000143157","A0A024R8Y1,Pogo transposable element with KRAB domain, isoform CRA_a","XP_011508116.1,-;XP_016857403.1,-;XP_005245427.1,-;NP_060012.3,pogo transposable element with KRAB domain isoform 1","PF03184,superfamily endonuclease;PF09607,Brinker DNA-binding domain;PF01352,KRAB box;PF03221,Tc5 transposase DNA-binding domain","IPR009057,Homeobox-like domain superfamily;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR006600,HTH CenpB-type DNA-binding domain;IPR004875,DDE superfamily endonuclease domain;IPR018586,Brinker DNA-binding domain","ENOG4110CDI,-;KOG3105,DNA-binding centromere protein B (CENP-B)","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding;GO:0005622,cellular_component,intracellular","-"]
["ZMYM4-AS1",24.83243349,5.710909718,2.105962593,2.973341394,{"v":6.82e-05,"d":"6.82E-05"},2.14107E-4,"ENSG00000227409","M3WQK4,Zinc finger MYM-type containing 4","XP_011283041.1,zinc finger MYM-type protein 4 isoform X1","PF06467,MYM-type Zinc finger with FCS sequence motif;PF12012,omain of unknown function (DUF3504)","IPR021893,Protein of unknown function DUF3504;IPR011017,TRASH domain;IPR010507,Zinc finger, MYM-type","ENOG410XQR6,-;ENOG410IE8I,-","GO:0022604,biological_process,regulation of cell morphogenesis;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0007010,biological_process,cytoskeleton organization;GO:0003677,molecular_function,DNA binding;GO:0007275,biological_process,multicellular organism development;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["KIAA1107",2.803957435,0.644848108,2.105962593,2.973341394,{"v":6.82e-05,"d":"6.82E-05"},2.14107E-4,"ENSG00000069712","E9PEZ5,Uncharacterized protein KIAA1107","-","PF15363,omain of unknown function (DUF4596)","IPR027907,Domain of unknown function DUF4596","ENOG410IFU8,-;ENOG4111MST,-","-","-"]
["RP11-488L18.4",5.276892117,1.213568315,2.105962593,2.973341394,{"v":6.82e-05,"d":"6.82E-05"},2.14107E-4,"ENSG00000227671","K7EV36,Uncharacterized protein","XP_009243270.1,zinc finger protein 682-like","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["STARD7-AS1",4.852314591,1.115924887,2.105962593,2.973341394,{"v":6.82e-05,"d":"6.82E-05"},2.14107E-4,"ENSG00000204685","Q3KRF4,Uncharacterized protein","-","-","-","-","-","-"]
["ZNF717",1.65886872,0.381503065,2.105962593,2.973341394,{"v":6.82e-05,"d":"6.82E-05"},2.14107E-4,"ENSG00000227124","C9JVC3,Zinc finger protein 717","NP_001277138.1,zinc finger protein 717 isoform b","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["RAB28",5.131961717,1.180237533,2.105962593,2.973341394,{"v":6.82e-05,"d":"6.82E-05"},2.14107E-4,"ENSG00000157869","K7BAC3,RAB28, member RAS oncogene family","-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0078,GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins;ENOG410XPUI,-","GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding;GO:0019003,molecular_function,GDP binding","-"]
["AL592183.1",30.64001875,7.046525701,2.105962593,2.973341394,{"v":6.82e-05,"d":"6.82E-05"},2.14107E-4,"ENSG00000273748","Q05D61,LOC283788 protein","-","PF06229,RG1-like domain","IPR010414,Protein FRG1","ENOG411009G,-;KOG3962,Predicted actin-bundling protein","-","-"]
["SUV39H1",3.384230099,0.778297969,2.105962593,2.973341394,{"v":6.82e-05,"d":"6.82E-05"},2.14107E-4,"ENSG00000101945","F7APZ4,Histone-lysine N-methyltransferase","XP_014982802.1,-","PF00856,SET domain","IPR023780,Chromo domain;IPR007728,Pre-SET domain;IPR016197,Chromo-like domain superfamily;IPR011381,Histone H3-K9 methyltransferase;IPR003616,Post-SET domain;IPR001214,SET domain;IPR023779,Chromo domain, conserved site;IPR000953,Chromo/chromo shadow domain","COG2940,Proteins containing SET domain;KOG1082,Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing","GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0051567,biological_process,histone H3-K9 methylation;GO:0000792,cellular_component,heterochromatin;GO:0042054,molecular_function,histone methyltransferase activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005694,cellular_component,chromosome;GO:0034968,biological_process,histone lysine methylation;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0033553,cellular_component,rDNA heterochromatin;GO:0047485,molecular_function,protein N-terminus binding;GO:0000183,biological_process,chromatin silencing at rDNA;GO:0008757,molecular_function,S-adenosylmethionine-dependent methyltransferase activity;GO:0005677,cellular_component,chromatin silencing complex;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0046974,molecular_function,histone methyltransferase activity (H3-K9 specific);GO:0071456,biological_process,cellular response to hypoxia;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["KDM3A",4.210348996,0.976423885,2.105454893,5.16324297,{"v":9.66e-12,"d":"9.66E-12"},{"v":1.39e-10,"d":"1.39E-10"},"ENSG00000115548","F5H070,Lysine-specific demethylase 3A","-","PF02373,JmjC domain, hydroxylase","IPR003347,JmjC domain","KOG1356,Putative transcription factor 5qNCA, contains JmjC domain;ENOG410XTAA,-","GO:0005654,cellular_component,nucleoplasm","-"]
["ZBTB7A",33.51402574,7.783795377,2.105364173,6.898417864,{"v":7.59e-18,"d":"7.59E-18"},{"v":4.14e-16,"d":"4.14E-16"},"ENSG00000178951","K7DEE1,Zinc finger and BTB domain containing 7A","-","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["PAFAH1B1",15.10605329,3.507655927,2.105211146,6.261223584,{"v":8.65e-16,"d":"8.65E-16"},{"v":3.19e-14,"d":"3.19E-14"},"ENSG00000007168","G3HVB8,Platelet-activating factor acetylhydrolase IB subunit alpha","XP_007623064.1,-;XP_007623063.1,-;XP_007646028.1,-;XP_003507316.1,-","PF08513,LisH;PF00400,WD domain, G-beta repeat","IPR017252,Dynein regulator LIS1;IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR006594,LIS1 homology motif;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR037190,LIS1, N-terminal;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat","-","GO:0006629,biological_process,lipid metabolic process;GO:0090102,biological_process,cochlea development;GO:0060117,biological_process,auditory receptor cell development;GO:0042249,biological_process,establishment of planar polarity of embryonic epithelium;GO:0050885,biological_process,neuromuscular process controlling balance;GO:0000132,biological_process,establishment of mitotic spindle orientation;GO:0048854,biological_process,brain morphogenesis;GO:0007017,biological_process,microtubule-based process;GO:0005856,cellular_component,cytoskeleton;GO:0005815,cellular_component,microtubule organizing center;GO:1904115,cellular_component,axon cytoplasm;GO:0021819,biological_process,layer formation in cerebral cortex;GO:0051301,biological_process,cell division;GO:0008017,molecular_function,microtubule binding;GO:0051081,biological_process,nuclear envelope disassembly;GO:0043087,biological_process,regulation of GTPase activity;GO:0005635,cellular_component,nuclear envelope;GO:0005634,cellular_component,nucleus;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0007399,biological_process,nervous system development;GO:0016787,molecular_function,hydrolase activity;GO:0007268,biological_process,chemical synaptic transmission;GO:0009306,biological_process,protein secretion;GO:0008090,biological_process,retrograde axonal transport;GO:0005737,cellular_component,cytoplasm;GO:0051130,biological_process,positive regulation of cellular component organization;GO:0042803,molecular_function,protein homodimerization activity;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0005938,cellular_component,cell cortex;GO:0000776,cellular_component,kinetochore;GO:0016042,biological_process,lipid catabolic process;GO:0051661,biological_process,maintenance of centrosome location;GO:0008344,biological_process,adult locomotory behavior;GO:0005813,cellular_component,centrosome;GO:0019226,biological_process,transmission of nerve impulse;GO:0031023,biological_process,microtubule organizing center organization;GO:0001675,biological_process,acrosome assembly;GO:0007611,biological_process,learning or memory;GO:0030036,biological_process,actin cytoskeleton organization;GO:0021540,biological_process,corpus callosum morphogenesis;GO:0000235,cellular_component,astral microtubule;GO:0030154,biological_process,cell differentiation;GO:0090176,biological_process,microtubule cytoskeleton organization involved in establishment of planar polarity;GO:0032420,cellular_component,stereocilium;GO:0007405,biological_process,neuroblast proliferation;GO:0046329,biological_process,negative regulation of JNK cascade;GO:0007049,biological_process,cell cycle;GO:0040019,biological_process,positive regulation of embryonic development;GO:0016020,cellular_component,membrane;GO:0031965,cellular_component,nuclear membrane;GO:0005875,cellular_component,microtubule associated complex;GO:0070507,biological_process,regulation of microtubule cytoskeleton organization;GO:0001764,biological_process,neuron migration;GO:0001961,biological_process,positive regulation of cytokine-mediated signaling pathway;GO:0005874,cellular_component,microtubule;GO:0021987,biological_process,cerebral cortex development;GO:0021766,biological_process,hippocampus development;GO:0043622,biological_process,cortical microtubule organization;GO:0061003,biological_process,positive regulation of dendritic spine morphogenesis;GO:0005819,cellular_component,spindle;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0001667,biological_process,ameboidal-type cell migration;GO:0031252,cellular_component,cell leading edge;GO:0031514,cellular_component,motile cilium;GO:0070840,molecular_function,dynein complex binding;GO:0036035,biological_process,osteoclast development;GO:0051219,molecular_function,phosphoprotein binding;GO:0047496,biological_process,vesicle transport along microtubule;GO:0007275,biological_process,multicellular organism development;GO:0016477,biological_process,cell migration","K16794,ko00565,Ether lipid metabolism"]
["NTN4",24.05381212,5.584278589,2.105185239,5.972550662,{"v":8.39e-15,"d":"8.39E-15"},{"v":2.46e-13,"d":"2.46E-13"},"ENSG00000074527","B2RE43,cDNA, FLJ96916, highly similar to Homo sapiens netrin 4","NP_001316629.1,netrin-4 isoform 2 precursor","PF00055,Laminin N-terminal (Domain VI);PF00053,Laminin EGF domain;PF01759,UNC-6/NTR/C345C module","IPR008993,Tissue inhibitor of metalloproteinases-like, OB-fold;IPR008211,Laminin, N-terminal;IPR001134,Netrin domain;IPR035811,Netrin-4, NTR domain;IPR018933,Netrin module, non-TIMP type;IPR002049,Laminin EGF domain;IPR038684,Laminin, N-terminal domain superfamily","KOG0994,Extracellular matrix glycoprotein Laminin subunit beta;ENOG410XPEG,-","GO:0005576,cellular_component,extracellular region","-"]
["ZNF646",3.767462641,0.872757294,2.104892202,4.392848402,{"v":4.96e-09,"d":"4.96E-09"},{"v":3.9e-08,"d":"3.90E-08"},"ENSG00000167395","G3R452,Zinc finger protein 646","XP_004057577.1,zinc finger protein 646 isoform X2;XP_018867955.1,-","PF00096,Zinc finger, C2H2 type;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["HECTD3",10.28978372,2.38793529,2.104237054,5.053059669,{"v":1.95e-11,"d":"1.95E-11"},{"v":2.64e-10,"d":"2.64E-10"},"ENSG00000126107","G3QGP7,HECT domain E3 ubiquitin protein ligase 3","XP_004025725.1,-","PF00632,HECT-domain (ubiquitin-transferase);PF03256,Anaphase-promoting complex, subunit 10 (APC10)","IPR004939,APC10/DOC domain;IPR035983,HECT, E3 ligase catalytic domain;IPR008979,Galactose-binding-like domain superfamily;IPR000569,HECT domain","-","GO:0016567,biological_process,protein ubiquitination;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0019905,molecular_function,syntaxin binding;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016740,molecular_function,transferase activity","-"]
["ATXN7L1",3.750124054,0.869029029,2.104185178,4.331044184,{"v":1.18E-8,"d":"1.18E-08"},{"v":8.6e-08,"d":"8.60E-08"},"ENSG00000146776","H2QV75,Uncharacterized protein","XP_001161812.2,ataxin-7-like protein 1 isoform X14","PF08313,SCA7, zinc-binding domain","IPR013243,SCA7 domain","KOG4140,Nuclear protein Ataxin-7;ENOG4111ZIZ,-","-","-"]
["BPTF",37.60545816,8.746083479,2.103944499,8.455364691,{"v":6.98e-21,"d":"6.98E-21"},{"v":6.69e-19,"d":"6.69E-19"},"ENSG00000171634","H2QDQ7,Uncharacterized protein","XP_009431392.1,nucleosome-remodeling factor subunit BPTF isoform X10","PF15612,WSTF, HB1, Itc1p, MBD9 motif 1;PF00439,Bromodomain;PF00628,PHD-finger;PF02791,T domain;PF15613,Williams-Beuren syndrome DDT (WSD), D-TOX E motif","IPR028941,WHIM2 domain;IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR028942,WHIM1 domain;IPR038028,Nucleosome-remodeling factor subunit BPTF;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR018501,DDT domain;IPR036427,Bromodomain-like superfamily;IPR001487,Bromodomain;IPR019787,Zinc finger, PHD-finger;IPR018359,Bromodomain, conserved site;IPR019786,Zinc finger, PHD-type, conserved site","KOG1632,Uncharacterized PHD Zn-finger protein;COG5076,Transcription factor involved in chromatin remodeling, contains bromodomain;KOG1473,Nucleosome remodeling factor, subunit NURF301/BPTF","GO:0043565,molecular_function,sequence-specific DNA binding;GO:0046872,molecular_function,metal ion binding;GO:0006338,biological_process,chromatin remodeling;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008094,molecular_function,DNA-dependent ATPase activity;GO:0007420,biological_process,brain development;GO:0008134,molecular_function,transcription factor binding;GO:0016589,cellular_component,NURF complex;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0000790,cellular_component,nuclear chromatin;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0035064,molecular_function,methylated histone binding;GO:0005634,cellular_component,nucleus;GO:0048188,cellular_component,Set1C/COMPASS complex;GO:0005654,cellular_component,nucleoplasm","-"]
["CDC14A",1.787654795,0.41112101,2.103914231,2.798854375,0.000196752,0.000559224,"ENSG00000079335","H2R046,Uncharacterized protein","XP_016812445.1,dual specificity protein phosphatase CDC14A isoform X10","PF00782,ual specificity phosphatase, catalytic domain;PF14671,ual specificity protein phosphatase, N-terminal half","IPR029260,Dual specificity/tyrosine protein phosphatase, N-terminal;IPR029021,Protein-tyrosine phosphatase-like;IPR000387,Tyrosine specific protein phosphatases domain;IPR026068,Dual specificity protein phosphatase CDC14A;IPR000340,Dual specificity phosphatase, catalytic domain;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR020422,Dual specificity protein phosphatase domain;IPR016130,Protein-tyrosine phosphatase, active site","COG2453,Predicted protein-tyrosine phosphatase;KOG1720,Protein tyrosine phosphatase CDC14","GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0007096,biological_process,regulation of exit from mitosis;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0051256,biological_process,mitotic spindle midzone assembly;GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0000922,cellular_component,spindle pole;GO:0005813,cellular_component,centrosome;GO:0072686,cellular_component,mitotic spindle;GO:0071850,biological_process,mitotic cell cycle arrest;GO:0016791,molecular_function,phosphatase activity;GO:0060271,biological_process,cilium assembly;GO:0005634,cellular_component,nucleus;GO:0004722,molecular_function,protein serine/threonine phosphatase activity","-"]
["CACNB3",1.394285768,0.320654846,2.103914231,2.798854375,0.000196752,0.000559224,"ENSG00000167535","H2NH53,Calcium voltage-gated channel auxiliary subunit beta 3","XP_002823210.1,voltage-dependent L-type calcium channel subunit beta-3 isoform X2","PF12052,Voltage gated calcium channel subunit beta domain 4Aa N terminal;PF00625,uanylate kinase","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036028,SH3-like domain superfamily;IPR000584,Voltage-dependent calcium channel, L-type, beta subunit;IPR008145,Guanylate kinase/L-type calcium channel beta subunit;IPR008079,Voltage-dependent calcium channel, L-type, beta-3 subunit;IPR035760,Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain","ENOG410XRDI,-;KOG3812,L-type voltage-dependent Ca2+ channel, beta subunit","GO:0005245,molecular_function,voltage-gated calcium channel activity;GO:0005891,cellular_component,voltage-gated calcium channel complex;GO:0016020,cellular_component,membrane;GO:0070588,biological_process,calcium ion transmembrane transport;GO:0006816,biological_process,calcium ion transport;GO:0050852,biological_process,T cell receptor signaling pathway","K04864,ko04260,Cardiac muscle contraction;K04864,ko05410,Hypertrophic cardiomyopathy (HCM);K04864,ko04921,Oxytocin signaling pathway;K04864,ko04261,Adrenergic signaling in cardiomyocytes;K04864,ko04010,MAPK signaling pathway;K04864,ko05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);K04864,ko05414,Dilated cardiomyopathy"]
["ZNF254",1.311934504,0.301715879,2.103914231,2.798854375,0.000196752,0.000559224,"ENSG00000213096","H2QZD8,Zinc finger protein 254","XP_001149923.1,zinc finger protein 254 isoform X1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZGRF1",1.095608712,0.251965738,2.103914231,2.798854375,0.000196752,0.000559224,"ENSG00000138658","G1S333,Zinc finger GRF-type containing 1","-","PF13087,AAA domain;PF13086,AAA domain;PF06839,RF zinc finger;PF10382,Protein of unknown function (DUF2439)","IPR010666,Zinc finger, GRF-type;IPR018838,Domain of unknown function DUF2439;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG1802,RNA helicase nonsense mRNA reducing factor (pNORF1);COG1112,Superfamily I DNA and RNA helicases and helicase subunits","GO:0008270,molecular_function,zinc ion binding","-"]
["BAG2",1.499522794,0.344857031,2.103914231,2.798854375,0.000196752,0.000559224,"ENSG00000112208","H2QT89,BCL2-associated athanogene 2","XP_001158523.1,-","-","IPR037689,BAG family molecular chaperone regulator 2;IPR003103,BAG domain","KOG3633,BAG family molecular chaperone regulator 2;ENOG410XRW0,-","GO:0051087,molecular_function,chaperone binding;GO:0006457,biological_process,protein folding;GO:0050790,biological_process,regulation of catalytic activity;GO:0019538,biological_process,protein metabolic process;GO:0000774,molecular_function,adenyl-nucleotide exchange factor activity;GO:0042802,molecular_function,identical protein binding","K09556,ko04141,Protein processing in endoplasmic reticulum"]
["SESN1",1.947534876,0.447889888,2.103914231,2.798854375,0.000196752,0.000559224,"ENSG00000080546","H2QTI6,Sestrin 1","XP_016811587.1,-","PF04636,PA26 p53-induced protein (sestrin)","IPR029032,AhpD-like;IPR006730,Sestrin","KOG3746,Uncharacterized conserved protein;ENOG410XP7Z,-","GO:0042149,biological_process,cellular response to glucose starvation;GO:1904262,biological_process,negative regulation of TORC1 signaling;GO:0061700,cellular_component,GATOR2 complex;GO:1901031,biological_process,regulation of response to reactive oxygen species;GO:0001650,cellular_component,fibrillar center;GO:0098869,biological_process,cellular oxidant detoxification;GO:0005737,cellular_component,cytoplasm;GO:0072593,biological_process,reactive oxygen species metabolic process;GO:0070728,molecular_function,leucine binding;GO:0005634,cellular_component,nucleus;GO:0034198,biological_process,cellular response to amino acid starvation","K10141,ko04211,Longevity regulating pathway;K10141,ko04115,p53 signaling pathway"]
["RAB8A",53.47542089,12.43492558,2.103887843,7.427616337,{"v":4.18e-19,"d":"4.18E-19"},{"v":2.89e-17,"d":"2.89E-17"},"ENSG00000167461","J9NWR1,Ras-related protein Rab-8A","-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0078,GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins;ENOG410XPUI,-","GO:0048210,biological_process,Golgi vesicle fusion to target membrane;GO:0005813,cellular_component,centrosome;GO:0010506,biological_process,regulation of autophagy;GO:0019003,molecular_function,GDP binding;GO:0045335,cellular_component,phagocytic vesicle;GO:0097730,cellular_component,non-motile cilium;GO:0005525,molecular_function,GTP binding;GO:0006904,biological_process,vesicle docking involved in exocytosis;GO:0030140,cellular_component,trans-Golgi network transport vesicle;GO:0055038,cellular_component,recycling endosome membrane;GO:0005929,cellular_component,cilium;GO:0097546,cellular_component,ciliary base;GO:0005886,cellular_component,plasma membrane;GO:0036064,cellular_component,ciliary basal body;GO:0055037,cellular_component,recycling endosome;GO:0003924,molecular_function,GTPase activity;GO:0031489,molecular_function,myosin V binding;GO:0060271,biological_process,cilium assembly","-"]
["RAB7A",266.4762543,61.98712211,2.103740317,8.805166445,2.52E-21,{"v":2.62e-19,"d":"2.62E-19"},"ENSG00000075785","A0A250YCC6,Ras-related protein Rab-7a","XP_020035138.1,-;XP_020035139.1,-","-","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity","K07897,ko05152,Tuberculosis;K07897,ko05132,Salmonella infection;K07897,ko04144,Endocytosis;K07897,ko04145,Phagosome;K07897,ko05146,Amoebiasis"]
["FBXW8",9.55537052,2.218653623,2.103308834,4.974610547,{"v":2.67e-11,"d":"2.67E-11"},{"v":3.5e-10,"d":"3.50E-10"},"ENSG00000174989","H2Q6Y9,F-box and WD repeat domain containing 8","XP_509407.2,F-box/WD repeat-containing protein 8 isoform X1","PF12937,-box-like","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR036047,F-box-like domain superfamily;IPR001810,F-box domain","ENOG410IQD1,-;ENOG4110ZIH,-","GO:0019005,cellular_component,SCF ubiquitin ligase complex;GO:0005794,cellular_component,Golgi apparatus;GO:0016567,biological_process,protein ubiquitination;GO:0008283,biological_process,cell proliferation;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:1990393,cellular_component,3M complex;GO:0050775,biological_process,positive regulation of dendrite morphogenesis;GO:0060712,biological_process,spongiotrophoblast layer development;GO:0007030,biological_process,Golgi organization;GO:0005829,cellular_component,cytosol;GO:0060716,biological_process,labyrinthine layer blood vessel development;GO:0031467,cellular_component,Cul7-RING ubiquitin ligase complex;GO:0004842,molecular_function,ubiquitin-protein transferase activity","-"]
["ABCA12",7.187355714,1.670331921,2.102905962,5.417409406,{"v":8.47e-13,"d":"8.47E-13"},{"v":1.57e-11,"d":"1.57E-11"},"ENSG00000144452","H2QJD0,Uncharacterized protein","XP_016805928.1,ATP-binding cassette sub-family A member 12","PF12698,ABC-2 family transporter protein;PF00005,ABC transporter","IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR026082,ABC transporter A;IPR030371,ATP-binding cassette subfamily A member 12;IPR003593,AAA+ ATPase domain;IPR017871,ABC transporter, conserved site","COG1131,ABC-type multidrug transport system, ATPase component;KOG0059,Lipid exporter ABCA1 and related proteins, ABC superfamily","GO:0035627,biological_process,ceramide transport;GO:0005102,molecular_function,signaling receptor binding;GO:0016887,molecular_function,ATPase activity;GO:0097209,cellular_component,epidermal lamellar body;GO:0005524,molecular_function,ATP binding;GO:0061436,biological_process,establishment of skin barrier;GO:0031424,biological_process,keratinization;GO:0005737,cellular_component,cytoplasm;GO:0010875,biological_process,positive regulation of cholesterol efflux;GO:0055088,biological_process,lipid homeostasis;GO:0033700,biological_process,phospholipid efflux;GO:0005829,cellular_component,cytosol;GO:0005319,molecular_function,lipid transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0032940,biological_process,secretion by cell;GO:0000166,molecular_function,nucleotide binding;GO:0048286,biological_process,lung alveolus development;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:2000010,biological_process,positive regulation of protein localization to cell surface;GO:0016020,cellular_component,membrane;GO:0006869,biological_process,lipid transport;GO:0005215,molecular_function,transporter activity;GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0055085,biological_process,transmembrane transport;GO:0045055,biological_process,regulated exocytosis;GO:0072659,biological_process,protein localization to plasma membrane;GO:0034191,molecular_function,apolipoprotein A-I receptor binding;GO:0043129,biological_process,surfactant homeostasis;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005886,cellular_component,plasma membrane;GO:0030216,biological_process,keratinocyte differentiation","-"]
["PRKX",7.434431083,1.726682755,2.102803649,4.933718226,{"v":5.11e-11,"d":"5.11E-11"},{"v":6.23e-10,"d":"6.23E-10"},"ENSG00000183943","A0A024RBU5,Protein kinase, X-linked, isoform CRA_b","NP_005035.1,cAMP-dependent protein kinase catalytic subunit PRKX","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0616,cAMP-dependent protein kinase catalytic subunit (PKA);ENOG410XPQQ,-","GO:0016301,molecular_function,kinase activity;GO:0007155,biological_process,cell adhesion;GO:0005737,cellular_component,cytoplasm;GO:0016740,molecular_function,transferase activity;GO:0005634,cellular_component,nucleus;GO:0005524,molecular_function,ATP binding;GO:0001525,biological_process,angiogenesis;GO:0004672,molecular_function,protein kinase activity;GO:0001935,biological_process,endothelial cell proliferation;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["MTPN",16.79519438,3.905921862,2.101732616,5.325662043,{"v":2.42e-12,"d":"2.42E-12"},{"v":3.98e-11,"d":"3.98E-11"},"ENSG00000105887","F6YKL4,Myotrophin","XP_001499940.1,-","PF12796,Ankyrin repeats (3 copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","ENOG4111U90,-;KOG4214,Myotrophin and similar proteins","GO:2000812,biological_process,regulation of barbed-end actin filament capping;GO:0010613,biological_process,positive regulation of cardiac muscle hypertrophy;GO:0008290,cellular_component,F-actin capping protein complex;GO:0008361,biological_process,regulation of cell size","-"]
["TMEM126B",11.10637269,2.576823451,2.101617107,4.127780363,{"v":4.42e-08,"d":"4.42E-08"},{"v":2.81e-07,"d":"2.81E-07"},"ENSG00000171204","B4DP48,cDNA FLJ61147","-","PF07114,Transmembrane protein 126","IPR009801,Transmembrane protein 126","ENOG41118MK,-;ENOG410IZUN,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PARS2",3.642337124,0.837656869,2.101190328,2.599666478,0.000877812,0.002140789,"ENSG00000162396","H2PZ38,Uncharacterized protein","XP_513427.3,probable proline--tRNA ligase, mitochondrial","PF03129,Anticodon binding domain;PF00587,tRNA synthetase class II core domain (G, H, P, S and T)","IPR033730,Prokaryote proline-tRNA ligase core domain;IPR004154,Anticodon-binding;IPR006195,Aminoacyl-tRNA synthetase, class II;IPR036621,Anticodon-binding domain superfamily;IPR002314,Aminoacyl-tRNA synthetase, class II (G/ P/ S/T);IPR002316,Proline-tRNA ligase, class IIa","KOG2324,Prolyl-tRNA synthetase;COG0442,Prolyl-tRNA synthetase","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0006433,biological_process,prolyl-tRNA aminoacylation;GO:0004827,molecular_function,proline-tRNA ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","K01881,ko00970,Aminoacyl-tRNA biosynthesis"]
["SRGAP2C",1.169274413,0.268907218,2.101190328,2.599666478,0.000877812,0.002140789,"ENSG00000171943","M3YKW7,Uncharacterized protein","XP_004756518.1,SLIT-ROBO Rho GTPase-activating protein 2 isoform X3","PF00018,SH3 domain;PF00611,es/CIP4, and EFC/F-BAR homology domain;PF00620,RhoGAP domain","IPR035648,srGAP1/2/3, SH3 domain;IPR030252,SLIT-ROBO Rho GTPase-activating protein 2;IPR031160,F-BAR domain;IPR001060,FCH domain;IPR027267,AH/BAR domain superfamily;IPR008936,Rho GTPase activation protein;IPR001452,SH3 domain;IPR000198,Rho GTPase-activating protein domain;IPR036028,SH3-like domain superfamily","KOG3565,Cdc42-interacting protein CIP4;ENOG4110QCJ,-","GO:0005886,cellular_component,plasma membrane;GO:0021816,biological_process,extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration;GO:0045335,cellular_component,phagocytic vesicle;GO:0042803,molecular_function,protein homodimerization activity;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0048365,molecular_function,Rac GTPase binding;GO:0014069,cellular_component,postsynaptic density;GO:0045211,cellular_component,postsynaptic membrane;GO:0005096,molecular_function,GTPase activator activity;GO:0005829,cellular_component,cytosol;GO:0060996,biological_process,dendritic spine development;GO:0046847,biological_process,filopodium assembly;GO:0007165,biological_process,signal transduction;GO:0048812,biological_process,neuron projection morphogenesis","-"]
["CTD-2323K18.1",7.806908886,1.795416137,2.101190328,2.599666478,0.000877812,0.002140789,"ENSG00000260269","G3QPJ6,Uncharacterized protein","-","PF11538,Snurportin1","IPR002652,Importin-alpha, importin-beta-binding domain;IPR024721,Snurportin-1, N-terminal","-","GO:0006606,biological_process,protein import into nucleus;GO:0061608,molecular_function,nuclear import signal receptor activity;GO:0005622,cellular_component,intracellular","-"]
["PRMT9",2.127037878,0.489171603,2.101190328,2.599666478,0.000877812,0.002140789,"ENSG00000164169","H2QQ96,Protein arginine methyltransferase 10","-","PF06325,Ribosomal protein L11 methyltransferase (PrmA)","IPR025799,Protein arginine N-methyltransferase;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR011990,Tetratricopeptide-like helical domain superfamily","ENOG410Y35C,-;ENOG410INRY,-","GO:0035243,molecular_function,protein-arginine omega-N symmetric methyltransferase activity;GO:0019918,biological_process,peptidyl-arginine methylation, to symmetrical-dimethyl arginine;GO:0005737,cellular_component,cytoplasm;GO:0016740,molecular_function,transferase activity;GO:0006479,biological_process,protein methylation;GO:0035246,biological_process,peptidyl-arginine N-methylation;GO:0032259,biological_process,methylation;GO:0016274,molecular_function,protein-arginine N-methyltransferase activity;GO:0006397,biological_process,mRNA processing;GO:0008168,molecular_function,methyltransferase activity","-"]
["NSUN5P2",3.318542403,0.763191254,2.101190328,2.599666478,0.000877812,0.002140789,"ENSG00000106133","G3R7U5,NOP2/Sun RNA methyltransferase family member 5","XP_004045648.2,probable 28S rRNA (cytosine-C(5))-methyltransferase isoform X2","PF01189,16S rRNA methyltransferase RsmB/F","IPR001678,SAM-dependent methyltransferase RsmB/NOP2-type;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR023267,RNA (C5-cytosine) methyltransferase","-","GO:0003723,molecular_function,RNA binding;GO:0032259,biological_process,methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0016740,molecular_function,transferase activity","-"]
["MBNL3",0.700759507,0.161159166,2.101190328,2.599666478,0.000877812,0.002140789,"ENSG00000076770","G3RZ28,Muscleblind like splicing regulator 3","-","PF14608,RNA-binding, Nab2-type zinc finger;PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR000571,Zinc finger, CCCH-type","-","GO:0045662,biological_process,negative regulation of myoblast differentiation;GO:0043484,biological_process,regulation of RNA splicing;GO:0046872,molecular_function,metal ion binding","-"]
["ZNF252P",10.30516809,2.399808791,2.10064313,5.886706975,{"v":1.87e-14,"d":"1.87E-14"},{"v":5e-13,"d":"5.00E-13"},"ENSG00000196922","B4DGQ9,cDNA FLJ52642, weakly similar to Zinc finger protein 3","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["DIP2A",3.117791979,0.725079542,2.100444951,4.7573981,1.94E-10,{"v":2.08e-09,"d":"2.08E-09"},"ENSG00000160305","K7CC60,DIP2 disco-interacting protein 2 homolog A","XP_514951.4,disco-interacting protein 2 homolog A isoform X4","PF06464,MAP1-binding Domain;PF00501,AMP-binding enzyme","IPR000873,AMP-dependent synthetase/ligase;IPR010506,DMAP1-binding domain","KOG3628,Predicted AMP-binding protein;COG0318,Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II","GO:0042981,biological_process,regulation of apoptotic process;GO:0009986,cellular_component,cell surface;GO:0010629,biological_process,negative regulation of gene expression;GO:0003824,molecular_function,catalytic activity;GO:0008152,biological_process,metabolic process","-"]
["OSGIN2",9.029674399,2.09995799,2.100444951,4.7573981,1.94E-10,{"v":2.08e-09,"d":"2.08E-09"},"ENSG00000164823","K7B154,Oxidative stress induced growth inhibitor family member 2","-","-","IPR036188,FAD/NAD(P)-binding domain superfamily;IPR029731,OKL38 family;IPR029728,Oxidative stress-induced growth inhibitor 2","ENOG410ZAI8,-;ENOG410IF6I,-","-","-"]
["RP11-229P13.22",140.4249364,32.65748622,2.100444951,4.7573981,1.94E-10,{"v":2.08e-09,"d":"2.08E-09"},"-","-","-","-","-","-","-","-"]
["RAF1",7.535054948,1.753774015,2.100390898,5.227660127,{"v":4.43e-12,"d":"4.43E-12"},{"v":6.89e-11,"d":"6.89E-11"},"ENSG00000132155","A0A0S2Z559,V-raf-1 murine leukemia viral oncogene-like protein 1 isoform 2","-","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF02196,Raf-like Ras-binding domain;PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR020454,Diacylglycerol/phorbol-ester binding;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR003116,Raf-like Ras-binding;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR029071,Ubiquitin-like domain superfamily;IPR000719,Protein kinase domain","-","GO:0016301,molecular_function,kinase activity;GO:0005057,molecular_function,signal transducer activity, downstream of receptor;GO:0035556,biological_process,intracellular signal transduction;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0016310,biological_process,phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0016607,cellular_component,nuclear speck;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0007165,biological_process,signal transduction;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["IPO7",63.97821996,14.92462897,2.09953374,8.164523996,{"v":2.16e-20,"d":"2.16E-20"},{"v":1.9e-18,"d":"1.90E-18"},"ENSG00000205339","E1BGE5,Importin 7","NP_001179285.1,importin-7","PF08506,Cse1;PF03810,Importin-beta N-terminal domain","IPR016024,Armadillo-type fold;IPR013713,Exportin/Importin, Cse1-like;IPR001494,Importin-beta, N-terminal domain","KOG1991,Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily);COG5656,Importin, protein involved in nuclear import","GO:0046332,molecular_function,SMAD binding;GO:0045087,biological_process,innate immune response;GO:0006606,biological_process,protein import into nucleus;GO:0042393,molecular_function,histone binding;GO:0008536,molecular_function,Ran GTPase binding;GO:0007165,biological_process,signal transduction;GO:0005829,cellular_component,cytosol;GO:0006886,biological_process,intracellular protein transport;GO:0005635,cellular_component,nuclear envelope;GO:0005634,cellular_component,nucleus;GO:0008565,molecular_function,protein transporter activity;GO:0005654,cellular_component,nucleoplasm","K20223,ko04013,MAPK signaling pathway - fly"]
["AAK1",5.532153503,1.290778566,2.09835116,6.350604743,{"v":5.19e-16,"d":"5.19E-16"},{"v":1.99e-14,"d":"1.99E-14"},"ENSG00000115977","G3RTV8,AP2 associated kinase 1","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["LRCH3",11.32909784,2.644328776,2.097921235,6.481826318,{"v":1.65e-16,"d":"1.65E-16"},{"v":6.92e-15,"d":"6.92E-15"},"ENSG00000186001","B4DEQ7,cDNA FLJ50003, highly similar to Homo sapiens leucine-rich repeats and calponin homology","-","PF13855,Leucine rich repeat;PF00307,Calponin homology (CH) domain","IPR001611,Leucine-rich repeat;IPR001715,Calponin homology domain;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily;IPR036872,CH domain superfamily","COG4886,Leucine-rich repeat (LRR) protein;KOG0532,Leucine-rich repeat (LRR) protein, contains calponin homology domain","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ADGRA3",8.805278901,2.054538358,2.097553387,5.680101643,{"v":9.74e-14,"d":"9.74E-14"},{"v":2.22e-12,"d":"2.22E-12"},"ENSG00000152990","G3SEX9,Uncharacterized protein","XP_018881388.1,adhesion G protein-coupled receptor A3","PF00002,7 transmembrane receptor (Secretin family);PF13855,Leucine rich repeat;PF01825,PCR proteolysis site, GPS, motif;PF07679,Immunoglobulin I-set domain","IPR001611,Leucine-rich repeat;IPR001879,GPCR, family 2, extracellular hormone receptor domain;IPR007110,Immunoglobulin-like domain;IPR036445,GPCR family 2, extracellular hormone receptor domain superfamily;IPR000832,GPCR, family 2, secretin-like;IPR017981,GPCR, family 2-like;IPR000483,Cysteine-rich flanking region, C-terminal;IPR000203,GPS motif;IPR032675,Leucine-rich repeat domain superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR013098,Immunoglobulin I-set","-","GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["ZBTB8A",1.006898143,0.231564272,2.097390704,2.367541025,0.002827279,0.006141927,"ENSG00000160062","H2N847,Zinc finger and BTB domain containing 8A","XP_009251318.1,-;XP_002811153.1,zinc finger and BTB domain-containing protein 8A isoform X1;XP_009251326.1,-;XP_009251329.1,-","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["KIAA1683",0.778217649,0.178972823,2.097390704,2.367541025,0.002827279,0.006141927,"ENSG00000130518","G3RGT0,KIAA1683","XP_004060341.1,uncharacterized protein KIAA1683 homolog isoform X1","PF00612,IQ calmodulin-binding motif","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR000048,IQ motif, EF-hand binding site","-","GO:0005739,cellular_component,mitochondrion","-"]
["VIT",1.9201629,0.441594939,2.097390704,2.367541025,0.002827279,0.006141927,"ENSG00000205221","K7B8V8,Vitrin","-","PF00092,von Willebrand factor type A domain;PF03815,LCCL domain","-","-","-","-"]
["XXbac-BPG181M17.6",12.34628138,2.839371275,2.097390704,2.367541025,0.002827279,0.006141927,"ENSG00000263756","M3XS87,Uncharacterized protein","-","-","-","-","-","-"]
["BAHCC1",1.568615225,0.364800095,2.096593014,3.802026253,{"v":5.62e-07,"d":"5.62E-07"},{"v":2.8e-06,"d":"2.80E-06"},"ENSG00000266074","A0A075B747,BAH and coiled-coil domain-containing protein 1","-","PF01426,BAH domain","IPR001025,Bromo adjacent homology (BAH) domain","-","GO:0003682,molecular_function,chromatin binding","-"]
["EFNB1",6.377173485,1.48308741,2.096593014,3.802026253,{"v":5.62e-07,"d":"5.62E-07"},{"v":2.8e-06,"d":"2.80E-06"},"ENSG00000090776","G3R3A6,Ephrin B1","XP_004064354.1,-","PF00812,phrin","IPR001799,Ephrin receptor-binding domain;IPR008972,Cupredoxin;IPR034255,Ephrin-B ectodomain;IPR019765,Ephrin, conserved site;IPR031328,Ephrin","-","GO:0045121,cellular_component,membrane raft;GO:0001755,biological_process,neural crest cell migration;GO:0031295,biological_process,T cell costimulation;GO:0005737,cellular_component,cytoplasm;GO:0007411,biological_process,axon guidance;GO:0048013,biological_process,ephrin receptor signaling pathway;GO:0046875,molecular_function,ephrin receptor binding;GO:0009880,biological_process,embryonic pattern specification;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0042102,biological_process,positive regulation of T cell proliferation;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","K05463,ko04360,Axon guidance"]
["HIC2",2.730183136,0.635446493,2.094887778,3.70745679,{"v":1.25e-06,"d":"1.25E-06"},{"v":5.82e-06,"d":"5.82E-06"},"ENSG00000169635","K7BYE0,Hypermethylated in cancer 2","XP_016795264.1,hypermethylated in cancer 2 protein","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["FBXW2",9.824773835,2.298269747,2.094407644,6.115438264,3.11E-15,1.01E-13,"ENSG00000119402","M1ERD8,F-box and WD repeat domain containing 2","-","PF12937,-box-like;PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat;IPR036047,F-box-like domain superfamily;IPR001810,F-box domain","ENOG410XP3H,-;ENOG410IQD2,-","-","-"]
["ZFHX3",9.91734938,2.321331611,2.094066321,6.757345782,{"v":2.85e-17,"d":"2.85E-17"},{"v":1.4e-15,"d":"1.40E-15"},"ENSG00000140836","G7NQN0,Zinc finger homeodomain protein 3","-","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type;PF00046,Homeobox domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR017970,Homeobox, conserved site;IPR003604,Matrin/U1-C-like, C2H2-type zinc finger;IPR009057,Homeobox-like domain superfamily;IPR001356,Homeobox domain","KOG1146,Homeobox protein;ENOG410XYHC,-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["SHB",20.64870829,4.827237243,2.093954113,5.188713807,7.81E-12,1.15E-10,"ENSG00000107338","K7CHY5,Src homology 2 domain containing adaptor protein B","XP_016816394.1,-","PF00017,SH2 domain","IPR035040,SH2 domain-containing adapter protein B;IPR035045,SHB, SH2 domain;IPR036860,SH2 domain superfamily;IPR000980,SH2 domain","ENOG410IGWI,-;ENOG410XQJ2,-","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0030097,biological_process,hemopoiesis;GO:0050852,biological_process,T cell receptor signaling pathway;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:0071425,biological_process,hematopoietic stem cell proliferation;GO:0042100,biological_process,B cell proliferation;GO:0045624,biological_process,positive regulation of T-helper cell differentiation;GO:0005070,molecular_function,SH3/SH2 adaptor activity;GO:1900194,biological_process,negative regulation of oocyte maturation;GO:0001568,biological_process,blood vessel development;GO:0009967,biological_process,positive regulation of signal transduction;GO:0005829,cellular_component,cytosol;GO:0048514,biological_process,blood vessel morphogenesis;GO:0045931,biological_process,positive regulation of mitotic cell cycle;GO:0007165,biological_process,signal transduction;GO:0005654,cellular_component,nucleoplasm","-"]
["MAL2",87.71486999,20.53867076,2.093938946,7.544929508,{"v":3.73e-19,"d":"3.73E-19"},2.63E-17,"ENSG00000147676","A0A024R9E4,Mal, T-cell differentiation protein 2, isoform CRA_a","NP_443118.1,protein MAL2","PF01284,Membrane-associating domain","IPR033240,Protein MAL2;IPR008253,Marvel domain;IPR013295,Myelin and lymphocyte (MAL) protein","-","GO:0045121,cellular_component,membrane raft;GO:0045056,biological_process,transcytosis;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ELK4",14.98060215,3.50817393,2.093411098,6.824309843,{"v":1.82e-17,"d":"1.82E-17"},{"v":9.33e-16,"d":"9.33E-16"},"ENSG00000158711","Q8IXL1,ELK4, ETS-domain protein","NP_001964.2,ETS domain-containing protein Elk-4 isoform a;NP_068567.1,ETS domain-containing protein Elk-4 isoform b","PF00178,ts-domain","IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000418,Ets domain","KOG3806,Predicted transcription factor;ENOG410Z0ZF,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","K04376,ko05202,Transcriptional misregulation in cancer;K04376,ko05166,HTLV-I infection;K04376,ko04010,MAPK signaling pathway"]
["ZER1",15.70388604,3.674029476,2.093320337,5.438793317,{"v":7.14e-13,"d":"7.14E-13"},1.35E-11,"ENSG00000160445","A0A024R8B0,Zyg-11 homolog B","XP_005251702.1,-;NP_006327.2,protein zer-1 homolog;XP_011516424.1,-;XP_016869674.1,-","-","IPR000225,Armadillo;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR032675,Leucine-rich repeat domain superfamily","ENOG410XPSX,-;KOG3665,ZYG-1-like serine/threonine protein kinases","-","-"]
["RP11-886H22.1",19.5346487,4.550881182,2.092919798,3.606149305,{"v":2.89e-06,"d":"2.89E-06"},{"v":1.24E-5,"d":"1.24E-05"},"ENSG00000266997","G3QZT8,Myosin VB","XP_018869521.1,unconventional myosin-Vb isoform X1","PF00063,Myosin head (motor domain);PF01843,IL domain;PF00612,IQ calmodulin-binding motif","IPR036103,Class V myosin, motor domain;IPR001609,Myosin head, motor domain;IPR037990,Myosin 5b, cargo-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR002710,Dilute domain;IPR000048,IQ motif, EF-hand binding site;IPR036961,Kinesin motor domain superfamily;IPR008989,Myosin S1 fragment, N-terminal","-","GO:0003777,molecular_function,microtubule motor activity;GO:0016459,cellular_component,myosin complex;GO:0005524,molecular_function,ATP binding;GO:0003779,molecular_function,actin binding;GO:0008017,molecular_function,microtubule binding;GO:0051015,molecular_function,actin filament binding;GO:0003774,molecular_function,motor activity;GO:0000166,molecular_function,nucleotide binding;GO:0007018,biological_process,microtubule-based movement","-"]
["ARVCF",3.252878703,0.757805513,2.092919798,3.606149305,{"v":2.89e-06,"d":"2.89E-06"},{"v":1.24E-5,"d":"1.24E-05"},"ENSG00000099889","B9EH95,Armadillo repeat gene deletes in velocardiofacial syndrome","-","PF00514,Armadillo/beta-catenin-like repeat","IPR000225,Armadillo;IPR016024,Armadillo-type fold;IPR028444,Armadillo repeat protein deleted in velo-cardio-facial syndrome;IPR028435,Plakophilin/Delta catenin","ENOG410Y21Q,-;KOG1048,Neural adherens junction protein Plakophilin and related Armadillo repeat proteins","GO:0005737,cellular_component,cytoplasm;GO:0005634,cellular_component,nucleus;GO:0098609,biological_process,cell-cell adhesion;GO:0005886,cellular_component,plasma membrane;GO:0016339,biological_process,calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007275,biological_process,multicellular organism development","-"]
["XPO7",23.26827592,5.453943579,2.091984256,6.64811266,{"v":7.56e-17,"d":"7.56E-17"},{"v":3.39e-15,"d":"3.39E-15"},"ENSG00000130227","F6UP51,Exportin 7","XP_017819199.1,-","PF03810,Importin-beta N-terminal domain","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR001494,Importin-beta, N-terminal domain","ENOG410XRPR,-;KOG1410,Nuclear transport receptor RanBP16 (importin beta superfamily)","GO:0008536,molecular_function,Ran GTPase binding;GO:0005634,cellular_component,nucleus;GO:0006886,biological_process,intracellular protein transport","-"]
["CCDC30",0.422026325,0.097056708,2.091721311,2.089280923,0.004327089,0.009020186,"ENSG00000186409","H2PYT5,Uncharacterized protein","XP_009453688.2,coiled-coil domain-containing protein 30 isoform X1","PF15742,omain of unknown function (DUF4686)","IPR031476,Protein of unknown function DUF4686","ENOG41115HA,-;ENOG410IIEM,-","-","-"]
["FAM227B",0.946684965,0.217716575,2.091721311,2.089280923,0.004327089,0.009020186,"ENSG00000166262","G1R2Q0,Family with sequence similarity 227 member B","XP_012362809.1,-;XP_003266946.1,protein FAM227B","PF14922,Protein of unknown function","IPR029417,FAM227 Protein","ENOG410IKCT,-;ENOG4111JGR,-","-","-"]
["PER1",0.813916522,0.187182774,2.091721311,2.089280923,0.004327089,0.009020186,"ENSG00000179094","A8K4U6,cDNA FLJ77255, highly similar to Homo sapiens period homolog 1","-","PF08447,PAS fold;PF12114,Period protein 2/3C-terminal region","IPR000014,PAS domain;IPR035965,PAS domain superfamily;IPR013655,PAS fold-3;IPR022728,Period circadian-like, C-terminal","ENOG410ZBUP,-;ENOG410IMRF,-","-","-"]
["LRRC37B",0.907346519,0.208669604,2.091721311,2.089280923,0.004327089,0.009020186,"ENSG00000185158","J3QSU1,Leucine-rich repeat-containing protein 37B","-","PF14914,LRRC37A/B like protein 1 C-terminal domain;PF13855,Leucine rich repeat;PF15779,Leucine-rich repeat-containing protein 37 family","IPR001611,Leucine-rich repeat;IPR032754,Leucine-rich repeat-containing protein 37, N-terminal;IPR032675,Leucine-rich repeat domain superfamily;IPR029423,LRRC37A/B like protein 1, C-terminal;IPR003591,Leucine-rich repeat, typical subtype;IPR015753,Leucine-rich repeat-containing protein 37","ENOG410YV94,-;ENOG410IJNR,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-344B2.2",7.382180682,1.697738057,2.091721311,2.089280923,0.004327089,0.009020186,"ENSG00000264982","B4DME6,cDNA FLJ57055","-","PF12736,Cell-cycle sustaining, positive selection,","IPR025946,CABIT domain;IPR013761,Sterile alpha motif/pointed domain superfamily","ENOG410II0U,-;ENOG410XSPW,-","-","-"]
["ZSCAN22",1.231160831,0.283139724,2.091721311,2.089280923,0.004327089,0.009020186,"ENSG00000182318","G3QK78,Zinc finger and SCAN domain containing 22","-","PF00096,Zinc finger, C2H2 type;PF02023,SCAN domain","-","-","-","-"]
["HELQ",1.53488917,0.352990514,2.091721311,2.089280923,0.004327089,0.009020186,"ENSG00000163312","K7AD24,Helicase, POLQ-like","-","PF00271,Helicase conserved C-terminal domain;PF00270,AD/DEAH box helicase","IPR011545,DEAD/DEAH box helicase domain;IPR001650,Helicase, C-terminal;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1204,Superfamily II helicase;KOG0950,DNA polymerase theta/eta, DEAD-box superfamily","GO:0003676,molecular_function,nucleic acid binding;GO:0004386,molecular_function,helicase activity;GO:0005524,molecular_function,ATP binding","-"]
["COQ3",3.908808976,0.898939493,2.091721311,2.089280923,0.004327089,0.009020186,"ENSG00000132423","H2QTG0,Ubiquinone biosynthesis O-methyltransferase, mitochondrial","XP_527458.2,ubiquinone biosynthesis O-methyltransferase, mitochondrial","PF13649,Methyltransferase domain;PF13489,Methyltransferase domain;PF02353,Mycolic acid cyclopropane synthetase;PF05175,Methyltransferase small domain;PF08242,Methyltransferase domain;PF13847,Methyltransferase domain;PF06325,Ribosomal protein L11 methyltransferase (PrmA);PF08241,Methyltransferase domain;PF05401,Nodulation protein S (NodS);PF01209,ubiE/COQ5 methyltransferase family","IPR010233,Ubiquinone biosynthesis O-methyltransferase;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase","COG2227,2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase;KOG1270,Methyltransferases","GO:0031314,cellular_component,extrinsic component of mitochondrial inner membrane;GO:0008689,molecular_function,3-demethylubiquinone-9 3-O-methyltransferase activity;GO:0044595,molecular_function,decaprenyldihydroxybenzoate methyltransferase activity;GO:0006744,biological_process,ubiquinone biosynthetic process;GO:0016740,molecular_function,transferase activity;GO:0006071,biological_process,glycerol metabolic process;GO:0008171,molecular_function,O-methyltransferase activity;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0008168,molecular_function,methyltransferase activity;GO:0016020,cellular_component,membrane;GO:0032259,biological_process,methylation;GO:0008425,molecular_function,2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity;GO:0044596,molecular_function,3-demethylubiquinone-10 3-O-methyltransferase activity;GO:0004395,molecular_function,hexaprenyldihydroxybenzoate methyltransferase activity;GO:0005739,cellular_component,mitochondrion","K00591,ko00130,Ubiquinone and other terpenoid-quinone biosynthesis"]
["SPIN3",1.025007821,0.235729097,2.091721311,2.089280923,0.004327089,0.009020186,"ENSG00000204271","K7BGN3,Spindlin family, member 3","XP_009437440.2,-;XP_016799323.1,-;XP_016799325.1,-;XP_016799324.1,-","PF02513,Spin/Ssty Family","IPR029567,Spindlin-3;IPR003671,Spindlin/spermiogenesis-specific protein","-","GO:0007276,biological_process,gamete generation","-"]
["HECTD4",1.877372271,0.439328675,2.091348109,4.703056918,4.03E-10,{"v":4.06e-09,"d":"4.06E-09"},"ENSG00000173064","J3KPF0,Probable E3 ubiquitin-protein ligase HECTD4","-","PF00632,HECT-domain (ubiquitin-transferase)","IPR000569,HECT domain;IPR035781,HECTD4, SPRY domain;IPR035983,HECT, E3 ligase catalytic domain","KOG1426,FOG: RCC1 domain;COG5184,Alpha-tubulin suppressor and related RCC1 domain-containing proteins","GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016740,molecular_function,transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["CCDC85C",11.52666302,2.704082531,2.090958637,6.968519261,{"v":9.11e-18,"d":"9.11E-18"},{"v":4.95e-16,"d":"4.95E-16"},"ENSG00000205476","K7AAL2,Coiled-coil domain containing 85C","XP_016782203.1,-","PF10226,CCDC85 family","IPR019359,CCDC85 family","KOG3819,Uncharacterized conserved proteins (Hepatitis delta antigen-interacting protein A);ENOG410YXPD,-","GO:0043296,cellular_component,apical junction complex;GO:0021987,biological_process,cerebral cortex development","-"]
["PITPNM2",1.840374448,0.429206565,2.090623276,3.497060684,{"v":3.29e-06,"d":"3.29E-06"},{"v":1.39e-05,"d":"1.39E-05"},"ENSG00000090975","H2Q753,Uncharacterized protein","XP_016779978.1,membrane-associated phosphatidylinositol transfer protein 2 isoform X7","PF02862,HD domain;PF02121,Phosphatidylinositol transfer protein","IPR031315,LNS2/PITP;IPR001666,Phosphatidylinositol transfer protein;IPR004177,DDHD domain;IPR036412,HAD-like superfamily;IPR023393,START-like domain superfamily","COG5083,Uncharacterized protein involved in plasmid maintenance;KOG3668,Phosphatidylinositol transfer protein","GO:0015914,biological_process,phospholipid transport;GO:0005548,molecular_function,phospholipid transporter activity;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["KIAA0513",1.907849985,0.444943006,2.090623276,3.497060684,{"v":3.29e-06,"d":"3.29E-06"},{"v":1.39e-05,"d":"1.39E-05"},"ENSG00000135709","G3RKH9,KIAA0513","XP_004058130.1,uncharacterized protein KIAA0513 homolog isoform X1","-","-","-","-","-"]
["ZNF274",3.36257016,0.786423725,2.090398977,4.189246972,{"v":2.94e-08,"d":"2.94E-08"},{"v":1.94e-07,"d":"1.94E-07"},"ENSG00000171606","H2QHB5,Zinc finger protein 274","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF02023,SCAN domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR003309,SCAN domain;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR038269,SCAN domain superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","K12458,ko04722,Neurotrophin signaling pathway"]
["ZNF721",4.385023027,1.025550689,2.090398977,4.189246972,{"v":2.94e-08,"d":"2.94E-08"},{"v":1.94e-07,"d":"1.94E-07"},"ENSG00000182903","D6RGC2,Zinc finger protein 721","-","PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["DNMBP-AS1",16.77265581,3.927472801,2.090302359,4.653494266,{"v":6.82e-10,"d":"6.82E-10"},{"v":6.52e-09,"d":"6.52E-09"},"ENSG00000227695","A0A1A6H373,Uncharacterized protein","-","PF07653,Variant SH3 domain;PF14604,Variant SH3 domain;PF00018,SH3 domain","IPR001452,SH3 domain;IPR036028,SH3-like domain superfamily;IPR035819,Dynamin-binding protein, third N-terminal SH3 domain;IPR035469,Dynamin-binding protein","-","-","-"]
["WWP1",19.82582337,4.654310299,2.089453811,6.296791053,{"v":8.54e-16,"d":"8.54E-16"},{"v":3.15e-14,"d":"3.15E-14"},"ENSG00000123124","H2QWD9,E3 ubiquitin-protein ligase","XP_519843.2,NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1;XP_009453873.1,-","PF00397,WW domain;PF00632,HECT-domain (ubiquitin-transferase);PF00168,C2 domain","IPR001202,WW domain;IPR000569,HECT domain;IPR024928,E3 ubiquitin-protein ligase, SMURF1 type;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR036020,WW domain superfamily;IPR035983,HECT, E3 ligase catalytic domain","KOG0940,Ubiquitin protein ligase RSP5/NEDD4;COG5021,Ubiquitin-protein ligase","GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0016740,molecular_function,transferase activity;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016874,molecular_function,ligase activity","K05633,ko04144,Endocytosis;K05633,ko04120,Ubiquitin mediated proteolysis"]
["NCOA7",6.255343981,1.466524371,2.089379397,4.963543692,{"v":3.99e-11,"d":"3.99E-11"},{"v":4.97e-10,"d":"4.97E-10"},"ENSG00000111912","H2R196,Nuclear receptor coactivator 7","XP_009450221.1,-;XP_001165718.1,nuclear receptor coactivator 7 isoform X1;XP_009450219.1,-;XP_016811760.1,-;XP_016811761.1,-;XP_009450222.1,-","PF01476,LysM domain;PF07534,TLD","IPR006571,TLDc domain;IPR018392,LysM domain;IPR036779,LysM domain superfamily","ENOG4110T63,-;ENOG410IMGK,-","GO:0005622,cellular_component,intracellular;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity;GO:0035257,molecular_function,nuclear hormone receptor binding;GO:1903204,biological_process,negative regulation of oxidative stress-induced neuron death;GO:1900408,biological_process,negative regulation of cellular response to oxidative stress;GO:1902083,biological_process,negative regulation of peptidyl-cysteine S-nitrosylation","-"]
["CSE1L",52.11625294,12.24426558,2.088810968,6.946792097,{"v":9.37e-18,"d":"9.37E-18"},{"v":5.06e-16,"d":"5.06E-16"},"ENSG00000124207","A0A0D9RR42,Chromosome segregation 1 like","XP_008012786.1,-;XP_008012777.1,-","PF08506,Cse1;PF03378,CAS/CSE protein, C-terminus;PF03810,Importin-beta N-terminal domain","IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR013713,Exportin/Importin, Cse1-like;IPR001494,Importin-beta, N-terminal domain;IPR005043,CAS/CSE, C-terminal","-","GO:0008536,molecular_function,Ran GTPase binding;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0005634,cellular_component,nucleus;GO:0006886,biological_process,intracellular protein transport","-"]
["PAG1",2.412731223,0.564783222,2.088809569,4.117737877,{"v":5.8e-08,"d":"5.80E-08"},{"v":3.61e-07,"d":"3.61E-07"},"ENSG00000076641","H2QWC2,Phosphoprotein associated with glycosphingolipid microdomains 1","XP_016815087.1,-;XP_016815088.1,-;XP_001168080.1,phosphoprotein associated with glycosphingolipid-enriched microdomains 1;XP_009453822.1,-;XP_016815086.1,-","PF15347,Phosphoprotein associated with glycosphingolipid-enriched","IPR032748,Phosphoprotein associated with glycosphingolipid-enriched microdomains 1","ENOG410IFZ3,-;ENOG4111TW0,-","GO:0045121,cellular_component,membrane raft;GO:0050863,biological_process,regulation of T cell activation;GO:0035556,biological_process,intracellular signal transduction;GO:0050868,biological_process,negative regulation of T cell activation;GO:0016020,cellular_component,membrane;GO:0042169,molecular_function,SH2 domain binding;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0005622,cellular_component,intracellular;GO:0005068,molecular_function,transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["HEATR1",10.02428727,2.353643931,2.088749326,5.834252753,{"v":3.03e-14,"d":"3.03E-14"},{"v":7.73e-13,"d":"7.73E-13"},"ENSG00000119285","B2RWN5,HEAT repeat containing 1","NP_060542.4,HEAT repeat-containing protein 1","PF12397,U3 small nucleolar RNA-associated protein 10;PF08146,BP28CT (NUC211) domain","IPR011989,Armadillo-like helical;IPR022125,U3 small nucleolar RNA-associated protein 10;IPR012954,BP28, C-terminal domain;IPR016024,Armadillo-type fold","KOG1837,Uncharacterized conserved protein;ENOG410XNQQ,-","-","K14550,ko03008,Ribosome biogenesis in eukaryotes"]
["MED13",10.22743862,2.403778527,2.087823277,6.342147025,7.83E-16,{"v":2.92e-14,"d":"2.92E-14"},"ENSG00000108510","A0A024QZ75,Mediator of RNA polymerase II transcription subunit 13","NP_005112.2,mediator of RNA polymerase II transcription subunit 13","PF06333,Mediator complex subunit 13 C-terminal;PF11597,Mediator complex subunit 13 N-terminal","IPR021643,Mediator complex, subunit Med13, N-terminal, metazoa/fungi;IPR009401,Mediator complex, subunit Med13","KOG3600,Thyroid hormone receptor-associated protein complex, subunit TRAP240;ENOG410XPV2,-","GO:0070328,biological_process,triglyceride homeostasis;GO:0016592,cellular_component,mediator complex;GO:1904168,biological_process,negative regulation of thyroid hormone receptor activity;GO:0042632,biological_process,cholesterol homeostasis;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component,nucleus","K15164,ko04919,Thyroid hormone signaling pathway"]
["DPYD",5.417762123,1.27139316,2.086659333,4.493609234,{"v":2.47e-09,"d":"2.47E-09"},{"v":2.08e-08,"d":"2.08E-08"},"ENSG00000188641","H2PZG2,Dihydropyrimidine dehydrogenase [NADP","XP_513583.3,dihydropyrimidine dehydrogenase","PF14691,ihydroprymidine dehydrogenase domain II, 4Fe-4S cluster;PF07992,Pyridine nucleotide-disulphide oxidoreductase;PF01180,ihydroorotate dehydrogenase;PF14697,4Fe-4S dicluster domain;PF13450,NAD(P)-binding Rossmann-like domain","IPR023753,FAD/NAD(P)-binding domain;IPR009051,Alpha-helical ferredoxin;IPR017896,4Fe-4S ferredoxin-type, iron-sulphur binding domain;IPR005720,Dihydroorotate dehydrogenase domain;IPR028261,Dihydroprymidine dehydrogenase domain II;IPR017900,4Fe-4S ferredoxin, iron-sulphur binding, conserved site;IPR013785,Aldolase-type TIM barrel;IPR036188,FAD/NAD(P)-binding domain superfamily","COG0493,NADPH-dependent glutamate synthase beta chain and related oxidoreductases;COG0167,Dihydroorotate dehydrogenase;COG1146,Ferredoxin;KOG0399,Glutamate synthase","GO:0005829,cellular_component,cytosol;GO:0006208,biological_process,pyrimidine nucleobase catabolic process;GO:0016627,molecular_function,oxidoreductase activity, acting on the CH-CH group of donors;GO:0005737,cellular_component,cytoplasm;GO:0003824,molecular_function,catalytic activity;GO:0006212,biological_process,uracil catabolic process;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0019483,biological_process,beta-alanine biosynthetic process;GO:0016491,molecular_function,oxidoreductase activity;GO:0051539,molecular_function,4 iron, 4 sulfur cluster binding;GO:0017113,molecular_function,dihydropyrimidine dehydrogenase (NADP+) activity;GO:0006210,biological_process,thymine catabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0006145,biological_process,purine nucleobase catabolic process;GO:0042803,molecular_function,protein homodimerization activity;GO:0006214,biological_process,thymidine catabolic process","-"]
["CCDC14",3.908124601,0.917905125,2.086443191,4.836166747,{"v":1.98e-10,"d":"1.98E-10"},{"v":2.12e-09,"d":"2.12E-09"},"ENSG00000175455","G3QVA5,Coiled-coil domain containing 14","XP_004036250.2,coiled-coil domain-containing protein 14 isoform X2","PF15254,Coiled-coil domain-containing protein 14","IPR029343,Coiled-coil domain-containing protein 14","-","-","-"]
["NFKB2",7.466967102,1.753774015,2.085240997,4.436085891,{"v":4.46e-09,"d":"4.46E-09"},{"v":3.54e-08,"d":"3.54E-08"},"ENSG00000077150","G3QVP8,Nuclear factor kappa B subunit 2","-","PF12796,Ankyrin repeats (3 copies);PF00531,eath domain;PF00554,Rel homology DNA-binding domain;PF16179,Rel homology dimerisation domain","IPR011539,Rel homology domain (RHD), DNA-binding domain;IPR020683,Ankyrin repeat-containing domain;IPR008967,p53-like transcription factor, DNA-binding;IPR032397,Rel homology dimerisation domain;IPR011029,Death-like domain superfamily;IPR030492,Rel homology domain, conserved site;IPR037059,Rel homology domain (RHD), DNA-binding domain superfamily;IPR000488,Death domain;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set;IPR002909,IPT domain;IPR002110,Ankyrin repeat;IPR033926,NFkappaB IPT domain;IPR000451,NF-kappa-B/Dorsal;IPR036770,Ankyrin repeat-containing domain superfamily","-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction","-"]
["ERO1A",10.69640294,2.517816616,2.084884935,5.669972151,{"v":1.51e-13,"d":"1.51E-13"},{"v":3.31e-12,"d":"3.31E-12"},"ENSG00000197930","H2Q8B5,ERO1-like","-","PF04137,ndoplasmic Reticulum Oxidoreductin 1 (ERO1)","IPR007266,Endoplasmic reticulum oxidoreductin 1;IPR037192,ERO1-like superfamily","COG5061,Oxidoreductin, endoplasmic reticulum membrane-associated protein involved in disulfide bond formation;KOG2608,Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation","GO:0003756,molecular_function,protein disulfide isomerase activity;GO:0016671,molecular_function,oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0034975,biological_process,protein folding in endoplasmic reticulum;GO:0005783,cellular_component,endoplasmic reticulum;GO:0015035,molecular_function,protein disulfide oxidoreductase activity;GO:0055114,biological_process,oxidation-reduction process;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0006464,biological_process,cellular protein modification process","K10950,ko05110,Vibrio cholerae infection;K10950,ko04141,Protein processing in endoplasmic reticulum"]
["FBLIM1",2.970769417,0.69479102,2.084649549,3.249951452,{"v":2.89e-05,"d":"2.89E-05"},{"v":9.87E-5,"d":"9.87E-05"},"ENSG00000162458","G3RGR5,Filamin binding LIM protein 1","XP_004024772.2,filamin-binding LIM protein 1 isoform X2;XP_018867098.1,-","PF00412,LIM domain","IPR001781,Zinc finger, LIM-type","-","GO:0046872,molecular_function,metal ion binding","-"]
["THTPA",4.841101787,1.132216465,2.084649549,3.249951452,{"v":2.89e-05,"d":"2.89E-05"},{"v":9.87E-5,"d":"9.87E-05"},"ENSG00000259431","G3RFP6,Thiamine-triphosphatase","XP_018865197.1,-;XP_018865195.1,thiamine-triphosphatase isoform X1","PF01928,CYTH domain","IPR023577,CYTH domain;IPR033469,CYTH-like domain superfamily;IPR012177,Thiamine triphosphatase","-","GO:0005737,cellular_component,cytoplasm;GO:0006772,biological_process,thiamine metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0050333,molecular_function,thiamin-triphosphatase activity","-"]
["VPS33B",3.49206096,0.816708487,2.084649549,3.249951452,{"v":2.89e-05,"d":"2.89E-05"},{"v":9.87E-5,"d":"9.87E-05"},"ENSG00000184056","A0A0S2Z577,Vacuolar protein sorting 33-like protein B isoform 1","NP_061138.3,vacuolar protein sorting-associated protein 33B isoform 1","PF00995,Sec1 family","IPR027121,Vacuolar protein sorting-associated protein 33;IPR027482,Sec1-like, domain 2;IPR036045,Sec1-like superfamily;IPR001619,Sec1-like protein","-","GO:0035855,biological_process,megakaryocyte development;GO:0032963,biological_process,collagen metabolic process;GO:0005622,cellular_component,intracellular;GO:0030199,biological_process,collagen fibril organization;GO:0017185,biological_process,peptidyl-lysine hydroxylation;GO:0006904,biological_process,vesicle docking involved in exocytosis;GO:0016192,biological_process,vesicle-mediated transport;GO:0070889,biological_process,platelet alpha granule organization;GO:0090330,biological_process,regulation of platelet aggregation;GO:0006886,biological_process,intracellular protein transport","-"]
["FAM83B",18.89483947,4.448856375,2.083795274,5.247481682,5.17E-12,{"v":7.88e-11,"d":"7.88E-11"},"ENSG00000168143","H2QT81,Uncharacterized protein","XP_009449766.1,-;XP_518551.1,protein FAM83B;XP_009449765.1,-","PF07894,Protein of unknown function (DUF1669)","IPR012461,FAM83","ENOG410IK0Q,-;ENOG410ZVMG,-","-","-"]
["ATXN1",8.094413881,1.907908699,2.083728734,6.384061251,5.16E-16,{"v":1.98e-14,"d":"1.98E-14"},"ENSG00000124788","G3SCV9,Ataxin 1","-","PF12547,Capicua transcriptional repressor modulator;PF08517,Ataxin-1 and HBP1 module (AXH)","-","-","-","-"]
["THG1L",9.955627209,2.340453179,2.083698306,4.37615362,{"v":8.17e-09,"d":"8.17E-09"},{"v":6.13E-8,"d":"6.13E-08"},"ENSG00000113272","H2QRW8,tRNA","XP_518066.2,probable tRNA(His) guanylyltransferase isoform X1","PF14413,Thg1 C terminal domain;PF04446,tRNAHis guanylyltransferase","IPR025845,Thg1 C-terminal domain;IPR038469,tRNAHis guanylyltransferase Thg1 superfamily;IPR007537,tRNAHis guanylyltransferase Thg1;IPR024956,tRNAHis guanylyltransferase catalytic domain","KOG2721,Uncharacterized conserved protein;COG4021,Uncharacterized conserved protein","GO:0005525,molecular_function,GTP binding;GO:0042802,molecular_function,identical protein binding;GO:0006400,biological_process,tRNA modification;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0051289,biological_process,protein homotetramerization;GO:0000287,molecular_function,magnesium ion binding;GO:0008193,molecular_function,tRNA guanylyltransferase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0099116,biological_process,tRNA 5'-end processing;GO:0008033,biological_process,tRNA processing;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0005739,cellular_component,mitochondrion","-"]
["USP6NL",8.711219243,2.053376046,2.083576297,6.276178063,{"v":1.27e-15,"d":"1.27E-15"},{"v":4.51e-14,"d":"4.51E-14"},"ENSG00000148429","X6RAB3,USP6 N-terminal-like protein","XP_016872462.1,USP6 N-terminal-like protein isoform X4","PF00566,Rab-GTPase-TBC domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain","KOG1102,Rab6 GTPase activator GAPCenA and related TBC domain proteins;COG5210,GTPase-activating protein","-","-"]
["PHLPP1",4.415688547,1.039404934,2.082893718,4.696370905,{"v":5.04e-10,"d":"5.04E-10"},{"v":4.97E-9,"d":"4.97E-09"},"ENSG00000081913","H2QEM7,PH domain and leucine rich repeat protein phosphatase 1","XP_523952.3,PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X1","PF13516,Leucine Rich repeat;PF13855,Leucine rich repeat;PF00481,Protein phosphatase 2C;PF00169,PH domain","IPR001611,Leucine-rich repeat;IPR001849,Pleckstrin homology domain;IPR032675,Leucine-rich repeat domain superfamily;IPR011993,PH-like domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR001932,PPM-type phosphatase domain;IPR036457,PPM-type phosphatase domain superfamily","KOG0619,FOG: Leucine rich repeat;COG0631,Serine/threonine protein phosphatase;COG4886,Leucine-rich repeat (LRR) protein","GO:0051896,biological_process,regulation of protein kinase B signaling;GO:0051898,biological_process,negative regulation of protein kinase B signaling;GO:0002667,biological_process,regulation of T cell anergy;GO:0042981,biological_process,regulation of apoptotic process;GO:0090036,biological_process,regulation of protein kinase C signaling;GO:0003824,molecular_function,catalytic activity;GO:0009649,biological_process,entrainment of circadian clock;GO:0006470,biological_process,protein dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0005886,cellular_component,plasma membrane;GO:0031965,cellular_component,nuclear membrane;GO:1900744,biological_process,regulation of p38MAPK cascade;GO:0046328,biological_process,regulation of JNK cascade;GO:0043408,biological_process,regulation of MAPK cascade;GO:0007165,biological_process,signal transduction;GO:0004722,molecular_function,protein serine/threonine phosphatase activity","-"]
["PUS7",9.13101667,2.149341757,2.082893718,4.696370905,{"v":5.04e-10,"d":"5.04E-10"},{"v":4.97E-9,"d":"4.97E-09"},"ENSG00000091127","H2QV72,Pseudouridylate synthase 7 homolog","XP_016801146.1,-;XP_527856.3,-;XP_016801145.1,-","PF01142,tRNA pseudouridine synthase D (TruD)","IPR001656,Pseudouridine synthase, TruD;IPR011760,Pseudouridine synthase, TruD, insertion domain;IPR020103,Pseudouridine synthase, catalytic domain superfamily;IPR020119,Pseudouridine synthase TruD, conserved site","COG0585,Uncharacterized conserved protein;KOG2339,Uncharacterized conserved protein","GO:0003723,molecular_function,RNA binding;GO:0001522,biological_process,pseudouridine synthesis;GO:0009451,biological_process,RNA modification;GO:0005634,cellular_component,nucleus;GO:0009982,molecular_function,pseudouridine synthase activity","-"]
["CKAP4",6.135583743,1.441070677,2.082841456,3.878816621,{"v":2.58e-07,"d":"2.58E-07"},{"v":1.38e-06,"d":"1.38E-06"},"ENSG00000136026","A0A024RBH2,Cytoskeleton-associated protein 4, isoform CRA_c","NP_006816.2,cytoskeleton-associated protein 4","-","IPR028428,Cytoskeleton-associated protein 4","ENOG410IIRS,-;ENOG4111Q54,-","GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016607,cellular_component,nuclear speck;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0016021,cellular_component,integral component of membrane","K13999,ko04141,Protein processing in endoplasmic reticulum"]
["C19orf44",5.0489151,1.185843728,2.082841456,3.878816621,{"v":2.58e-07,"d":"2.58E-07"},{"v":1.38e-06,"d":"1.38E-06"},"ENSG00000105072","G3RJP7,Chromosome 19 open reading frame 44","XP_018871216.1,-;XP_004060277.1,uncharacterized protein C19orf44 homolog isoform X2","PF15391,omain of unknown function (DUF4614)","IPR027884,Domain of unknown function DUF4614","-","-","-"]
["RP11-54O7.14",10.63254382,2.44524959,2.082351493,1.741736692,0.016186198,0.029240254,"-","-","-","-","-","-","-","-"]
["KIAA1614-AS1",2.968251816,0.682632177,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000232586","A0A1W2PPL5,Uncharacterized protein KIAA1614","-","-","IPR036034,PDZ superfamily;IPR001478,PDZ domain","-","-","-"]
["AGGF1P2",2.029573891,0.466757044,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000233435","G3SHS3,Uncharacterized protein","-","PF00498,HA domain","-","-","-","-"]
["DPP9-AS1",1.391821106,0.320088028,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000205790","Q6ZTZ0,cDNA FLJ44107 fis, clone TESTI4044296","NP_001229830.1,uncharacterized protein LOC100131094","-","-","-","-","-"]
["CTC-548K16.5",16.96143895,3.900755299,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000267379","B3KUI0,cDNA FLJ39945 fis, clone SPLEN2023977, highly similar to Homo sapiens CD97 antigen","-","PF00002,7 transmembrane receptor (Secretin family);PF07645,Calcium-binding EGF domain;PF01825,PCR proteolysis site, GPS, motif","IPR018097,EGF-like calcium-binding, conserved site;IPR000832,GPCR, family 2, secretin-like;IPR017981,GPCR, family 2-like;IPR000203,GPS motif;IPR001881,EGF-like calcium-binding domain;IPR003056,GPCR, family 2, CD97 antigen;IPR017983,GPCR, family 2, secretin-like, conserved site;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain","-","GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0016020,cellular_component,membrane;GO:0005509,molecular_function,calcium ion binding;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["SLC4A5",0.532620887,0.122491008,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000188687","H2R0C3,Anion exchange protein","-","PF07565,Band 3 cytoplasmic domain;PF00955,HCO3- transporter family","IPR013769,Band 3 cytoplasmic domain;IPR003024,Sodium bicarbonate cotransporter;IPR016152,Phosphotransferase/anion transporter;IPR003020,Bicarbonate transporter, eukaryotic;IPR011531,Bicarbonate transporter, C-terminal","KOG1172,Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family);ENOG410XPHD,-","GO:0008509,molecular_function,anion transmembrane transporter activity;GO:0048311,biological_process,mitochondrion distribution;GO:0002064,biological_process,epithelial cell development;GO:0005452,molecular_function,inorganic anion exchanger activity;GO:0060041,biological_process,retina development in camera-type eye;GO:0006811,biological_process,ion transport;GO:0098656,biological_process,anion transmembrane transport;GO:0005887,cellular_component,integral component of plasma membrane;GO:0003073,biological_process,regulation of systemic arterial blood pressure;GO:0010468,biological_process,regulation of gene expression;GO:0015698,biological_process,inorganic anion transport;GO:0033326,biological_process,cerebrospinal fluid secretion;GO:0015701,biological_process,bicarbonate transport;GO:0016020,cellular_component,membrane;GO:0008510,molecular_function,sodium:bicarbonate symporter activity;GO:0003014,biological_process,renal system process;GO:0051453,biological_process,regulation of intracellular pH;GO:0006820,biological_process,anion transport;GO:0016021,cellular_component,integral component of membrane","-"]
["LYPD6",0.849251463,0.195309027,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000187123","A0A0D9RUD0,LY6/PLAUR domain containing 6","XP_007963140.1,-","PF16975,Ly6/PLAUR domain-containing protein 6, Lypd6","IPR031574,Ly6/PLAUR domain-containing protein 6","-","GO:0099601,biological_process,regulation of neurotransmitter receptor activity;GO:0030550,molecular_function,acetylcholine receptor inhibitor activity;GO:0030548,molecular_function,acetylcholine receptor regulator activity;GO:2000272,biological_process,negative regulation of signaling receptor activity","-"]
["AC009299.3",1.798183683,0.413542421,2.082351493,1.741736692,0.016186198,0.029240254,"-","-","-","-","-","-","-","-"]
["AP001615.9",9.271762723,2.132300076,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000236883","L5MFX4,Receptor-interacting serine/threonine-protein kinase 4","-","PF12796,Ankyrin repeats (3 copies);PF00069,Protein kinase domain","IPR002110,Ankyrin repeat;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR000719,Protein kinase domain","-","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0016310,biological_process,phosphorylation","-"]
["CHKB-CPT1B",0.851111632,0.195736825,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000254413","G1QK27,Uncharacterized protein","-","PF01633,Choline/ethanolamine kinase","IPR011009,Protein kinase-like domain superfamily;IPR026712,Choline/Ethanolamine kinase","COG0510,Predicted choline kinase involved in LPS biosynthesis;KOG2686,Choline kinase","GO:0016301,molecular_function,kinase activity;GO:0006656,biological_process,phosphatidylcholine biosynthetic process;GO:0046474,biological_process,glycerophospholipid biosynthetic process;GO:0007517,biological_process,muscle organ development;GO:0006657,biological_process,CDP-choline pathway;GO:0004103,molecular_function,choline kinase activity;GO:0016310,biological_process,phosphorylation","-"]
["RP11-894J14.5",2.428569668,0.558517236,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000272305","U3KQE9,Uncharacterized protein","-","PF04506,Rft protein","IPR007594,RFT1","KOG2864,Nuclear division RFT1 protein;ENOG410Y1D5,-","GO:0034203,biological_process,glycolipid translocation;GO:0016020,cellular_component,membrane;GO:0006869,biological_process,lipid transport;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0005319,molecular_function,lipid transporter activity;GO:0016021,cellular_component,integral component of membrane","-"]
["SLC9B2",0.795363345,0.182915954,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000164038","A0A024RDJ7,Uncharacterized protein","XP_006714148.1,-;NP_849155.2,sodium/hydrogen exchanger 9B2 isoform 1","PF00999,Sodium/hydrogen exchanger family","IPR006153,Cation/H+ exchanger;IPR037072,Mitochondrial sodium/hydrogen exchnager 9B2","KOG3826,Na+/H+ antiporter;COG0025,NhaP-type Na+/H+ and K+/H+ antiporters","GO:1902600,biological_process,proton transmembrane transport;GO:0016021,cellular_component,integral component of membrane;GO:0055085,biological_process,transmembrane transport;GO:0006814,biological_process,sodium ion transport;GO:2001206,biological_process,positive regulation of osteoclast development;GO:0097708,cellular_component,intracellular vesicle;GO:0015299,molecular_function,solute:proton antiporter activity;GO:0016020,cellular_component,membrane;GO:0006812,biological_process,cation transport;GO:0072583,biological_process,clathrin-dependent endocytosis;GO:0016323,cellular_component,basolateral plasma membrane;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0030672,cellular_component,synaptic vesicle membrane;GO:0061178,biological_process,regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0097228,cellular_component,sperm principal piece;GO:0010008,cellular_component,endosome membrane;GO:0030317,biological_process,flagellated sperm motility;GO:0005886,cellular_component,plasma membrane","-"]
["RP11-83A24.2",0.537375234,0.123584402,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000273247","H2P484,Uncharacterized protein","-","-","-","ENOG410JE83,-;ENOG411219Y,-","-","-"]
["FASTKD3",1.496073719,0.344063821,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000124279","H2QQM2,FAST kinase domains 3","-","PF08373,RAP domain;PF06743,AST kinase-like protein, subdomain 1;PF08368,AST kinase-like protein, subdomain 2","IPR013579,FAST kinase-like protein, subdomain 2;IPR010622,FAST kinase leucine-rich","ENOG410IQQ6,-;ENOG4111H0K,-","GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity","-"]
["CTD-2201E18.3",1.535302663,0.353085609,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000177738","Q8N4J7,LOC648987 protein","-","-","-","-","-","-"]
["INHBA",0.514849749,0.118404039,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000122641","H2QUH0,Inhibin beta A subunit","XP_519063.2,-","PF00019,Transforming growth factor beta like domain;PF00688,TGF-beta propeptide","IPR017948,Transforming growth factor beta, conserved site;IPR000491,Inhibin, beta A subunit;IPR001111,TGF-beta, propeptide;IPR029034,Cystine-knot cytokine;IPR015615,Transforming growth factor-beta-related;IPR001839,Transforming growth factor-beta, C-terminal","ENOG410XT8Z,-;KOG3900,Transforming growth factor beta, bone morphogenetic protein and related proteins","GO:0001541,biological_process,ovarian follicle development;GO:0008083,molecular_function,growth factor activity;GO:0001942,biological_process,hair follicle development;GO:0042476,biological_process,odontogenesis;GO:0005102,molecular_function,signaling receptor binding;GO:0043512,cellular_component,inhibin A complex;GO:0048333,biological_process,mesodermal cell differentiation;GO:0045786,biological_process,negative regulation of cell cycle;GO:0030308,biological_process,negative regulation of cell growth;GO:0010862,biological_process,positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0051799,biological_process,negative regulation of hair follicle development;GO:0046880,biological_process,regulation of follicle-stimulating hormone secretion;GO:0005576,cellular_component,extracellular region;GO:0017046,molecular_function,peptide hormone binding;GO:0000082,biological_process,G1/S transition of mitotic cell cycle;GO:0060021,biological_process,roof of mouth development;GO:0005179,molecular_function,hormone activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0008584,biological_process,male gonad development;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0001707,biological_process,mesoderm formation;GO:0061029,biological_process,eyelid development in camera-type eye;GO:2001241,biological_process,positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0043509,cellular_component,activin A complex;GO:0005615,cellular_component,extracellular space;GO:0042802,molecular_function,identical protein binding;GO:0042493,biological_process,response to drug;GO:0032924,biological_process,activin receptor signaling pathway;GO:0010628,biological_process,positive regulation of gene expression;GO:0060395,biological_process,SMAD protein signal transduction;GO:0042981,biological_process,regulation of apoptotic process;GO:0070699,molecular_function,type II activin receptor binding;GO:0021773,biological_process,striatal medium spiny neuron differentiation;GO:0060279,biological_process,positive regulation of ovulation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0045648,biological_process,positive regulation of erythrocyte differentiation;GO:0042701,biological_process,progesterone secretion;GO:0042541,biological_process,hemoglobin biosynthetic process;GO:0032270,biological_process,positive regulation of cellular protein metabolic process;GO:0035987,biological_process,endodermal cell differentiation;GO:0007050,biological_process,cell cycle arrest;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0005125,molecular_function,cytokine activity;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0005160,molecular_function,transforming growth factor beta receptor binding;GO:0048468,biological_process,cell development;GO:0097154,biological_process,GABAergic neuron differentiation;GO:0043408,biological_process,regulation of MAPK cascade;GO:0097191,biological_process,extrinsic apoptotic signaling pathway","K04667,ko04350,TGF-beta signaling pathway;K04667,ko04550,Signaling pathways regulating pluripotency of stem cells;K04667,ko04060,Cytokine-cytokine receptor interaction"]
["GNGT1",1.810369596,0.416344911,2.082351493,1.741736692,0.016186198,0.029240254,"ENSG00000127928","G5ANK5,Guanine nucleotide-binding protein subunit gamma","XP_004862746.1,-","PF00631,L domain","IPR001770,G-protein, gamma subunit;IPR036284,G-protein gamma-like domain superfamily;IPR015898,G-protein gamma-like domain","-","GO:0042462,biological_process,eye photoreceptor cell development;GO:0007602,biological_process,phototransduction;GO:0008104,biological_process,protein localization;GO:0016020,cellular_component,membrane;GO:0004871,molecular_function,signal transducer activity;GO:0005834,cellular_component,heterotrimeric G-protein complex;GO:0005886,cellular_component,plasma membrane;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0007165,biological_process,signal transduction","-"]
["RNU6-146P",39.57669088,9.101762363,2.082351493,1.741736692,0.016186198,0.029240254,"-","-","-","-","-","-","-","-"]
["RP11-524D16__A.3",6.555648183,1.507653888,2.082351493,1.741736692,0.016186198,0.029240254,"-","-","-","-","-","-","-","-"]
["SERPINB5",14.46824952,3.410561373,2.081988668,5.179193932,{"v":1.12e-11,"d":"1.12E-11"},{"v":1.59e-10,"d":"1.59E-10"},"ENSG00000206075","A0A024R2B6,Serpin peptidase inhibitor, clade B","NP_002630.2,serpin B5","PF00079,Serpin (serine protease inhibitor)","IPR023795,Serpin, conserved site;IPR000240,Serpin B9/maspin;IPR023796,Serpin domain;IPR000215,Serpin family;IPR036186,Serpin superfamily;IPR033836,Maspin","KOG2392,Serpin;COG4826,Serine protease inhibitor","GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0050678,biological_process,regulation of epithelial cell proliferation;GO:0005737,cellular_component,cytoplasm;GO:0004867,molecular_function,serine-type endopeptidase inhibitor activity;GO:0030198,biological_process,extracellular matrix organization;GO:0060512,biological_process,prostate gland morphogenesis;GO:0002009,biological_process,morphogenesis of an epithelium;GO:0005615,cellular_component,extracellular space","K10139,ko05206,MicroRNAs in cancer;K10139,ko04115,p53 signaling pathway"]
["UBQLN1",16.58250558,3.913361365,2.081820612,6.209370898,{"v":1.9e-15,"d":"1.90E-15"},{"v":6.42e-14,"d":"6.42E-14"},"ENSG00000135018","G7NGE8,Protein linking IAP with cytoskeleton 1","XP_014973488.1,-","PF00627,UBA/TS-N domain;PF00240,Ubiquitin family","IPR006636,Heat shock chaperonin-binding;IPR015496,Ubiquilin;IPR009060,UBA-like superfamily;IPR028799,Ubiquilin-1;IPR015940,Ubiquitin-associated domain;IPR000626,Ubiquitin domain;IPR029071,Ubiquitin-like domain superfamily","COG5272,Ubiquitin;KOG0010,Ubiquitin-like protein","GO:0016236,biological_process,macroautophagy;GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0032991,cellular_component,protein-containing complex;GO:0005783,cellular_component,endoplasmic reticulum;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0005886,cellular_component,plasma membrane;GO:0031396,biological_process,regulation of protein ubiquitination;GO:1902175,biological_process,regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0035973,biological_process,aggrephagy;GO:0034140,biological_process,negative regulation of toll-like receptor 3 signaling pathway;GO:0005737,cellular_component,cytoplasm;GO:0005776,cellular_component,autophagosome;GO:0019900,molecular_function,kinase binding;GO:0005829,cellular_component,cytosol;GO:0097352,biological_process,autophagosome maturation;GO:0042802,molecular_function,identical protein binding;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0000045,biological_process,autophagosome assembly;GO:0071456,biological_process,cellular response to hypoxia;GO:0016235,cellular_component,aggresome;GO:0005654,cellular_component,nucleoplasm;GO:1903071,biological_process,positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:0031398,biological_process,positive regulation of protein ubiquitination;GO:1901340,biological_process,negative regulation of store-operated calcium channel activity;GO:0031593,molecular_function,polyubiquitin modification-dependent protein binding","K04523,ko04141,Protein processing in endoplasmic reticulum"]
["SP3",17.50336833,4.132526634,2.081679408,6.868794695,{"v":1.97e-17,"d":"1.97E-17"},{"v":9.9e-16,"d":"9.90E-16"},"ENSG00000172845","K7CG32,Sp3 transcription factor","XP_016805548.1,transcription factor Sp3","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR030452,Transcription factor Sp3;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0000987,molecular_function,proximal promoter sequence-specific DNA binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["MARVELD3",8.620179025,2.033282315,2.08101686,5.143793481,{"v":9.96e-12,"d":"9.96E-12"},1.43E-10,"ENSG00000140832","H2RA19,MARVEL domain containing 3","-","-","IPR008253,Marvel domain","ENOG410IYBG,-;ENOG4111KK6,-","GO:0070830,biological_process,bicellular tight junction assembly;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0006970,biological_process,response to osmotic stress;GO:0005923,cellular_component,bicellular tight junction;GO:0045216,biological_process,cell-cell junction organization;GO:1902414,biological_process,protein localization to cell junction;GO:0050680,biological_process,negative regulation of epithelial cell proliferation;GO:0016020,cellular_component,membrane;GO:0010633,biological_process,negative regulation of epithelial cell migration;GO:0046329,biological_process,negative regulation of JNK cascade;GO:0031435,molecular_function,mitogen-activated protein kinase kinase kinase binding;GO:0016021,cellular_component,integral component of membrane","-"]
["ALKBH3",5.30581269,1.243242414,2.080664821,3.108087119,{"v":7.67e-05,"d":"7.67E-05"},0.00023831,"ENSG00000166199","H2Q3G1,AlkB, alkylation repair homolog 3","XP_001159019.1,-;XP_009458538.1,-","PF13532,2OG-Fe(II) oxygenase superfamily","IPR027450,Alpha-ketoglutarate-dependent dioxygenase AlkB-like;IPR005123,Oxoglutarate/iron-dependent dioxygenase;IPR032854,Alkylated DNA repair protein alkB homologue 3;IPR037151,Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily","ENOG410IETS,-;COG3145,Alkylated DNA repair protein","GO:0005829,cellular_component,cytosol;GO:1990930,molecular_function,RNA N1-methyladenosine dioxygenase activity;GO:0051213,molecular_function,dioxygenase activity;GO:0006281,biological_process,DNA repair;GO:0008283,biological_process,cell proliferation;GO:0008198,molecular_function,ferrous iron binding;GO:0016491,molecular_function,oxidoreductase activity;GO:0006307,biological_process,DNA dealkylation involved in DNA repair;GO:0016706,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0005739,cellular_component,mitochondrion;GO:0055114,biological_process,oxidation-reduction process;GO:0043734,molecular_function,DNA-N1-methyladenine dioxygenase activity;GO:0051747,molecular_function,cytosine C-5 DNA demethylase activity;GO:0035553,biological_process,oxidative single-stranded RNA demethylation;GO:0005634,cellular_component,nucleus;GO:0035552,biological_process,oxidative single-stranded DNA demethylation;GO:0005654,cellular_component,nucleoplasm","-"]
["ZNF16",2.403167405,0.563103114,2.080664821,3.108087119,{"v":7.67e-05,"d":"7.67E-05"},0.00023831,"ENSG00000170631","Q8ND22,Uncharacterized protein DKFZp547L155","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["TSC22D1",19.22138376,4.54134055,2.080549947,6.687715512,6.75E-17,3.06E-15,"ENSG00000102804","H2NJS7,TSC22 domain family protein 1","-","PF01166,TSC-22/dip/bun family","IPR000580,TSC-22 / Dip / Bun","ENOG4111MFI,-;KOG4797,Transcriptional regulator","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity","-"]
["CIC",12.85596321,3.037116407,2.080349233,6.257516694,{"v":1.7E-15,"d":"1.70E-15"},{"v":5.86e-14,"d":"5.86E-14"},"ENSG00000079432","I3L2J0,Protein capicua homolog","-","PF00505,HMG (high mobility group) box;PF16090,omain of unknown function (DUF4819)","IPR032147,Domain of unknown function DUF4819;IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily","ENOG4111S7E,-;ENOG410ITBG,-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["ING3",5.601764072,1.319703174,2.080168148,4.24818562,{"v":1.52E-8,"d":"1.52E-08"},{"v":1.08E-7,"d":"1.08E-07"},"ENSG00000071243","H2QVA1,Inhibitor of growth protein","XP_016800878.1,-;XP_519334.2,-","PF12998,Inhibitor of growth proteins N-terminal histone-binding","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR038004,Inhibitor of growth protein 3;IPR019787,Zinc finger, PHD-finger;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR024610,Inhibitor of growth protein, N-terminal histone-binding;IPR019786,Zinc finger, PHD-type, conserved site","COG5034,Chromatin remodeling protein, contains PhD zinc finger;KOG1973,Chromatin remodeling protein, contains PHD Zn-finger","GO:0006325,biological_process,chromatin organization;GO:0035267,cellular_component,NuA4 histone acetyltransferase complex;GO:0000812,cellular_component,Swr1 complex;GO:0046872,molecular_function,metal ion binding;GO:0005634,cellular_component,nucleus","-"]
["JAK1",28.08021664,6.639373274,2.079531504,6.79099715,{"v":3.74e-17,"d":"3.74E-17"},{"v":1.8e-15,"d":"1.80E-15"},"ENSG00000162434","H2PZ66,Tyrosine-protein kinase","XP_016775413.1,-;XP_016775411.1,-;XP_016775408.1,tyrosine-protein kinase JAK1","PF07714,Protein tyrosine kinase","IPR019748,FERM central domain;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR036860,SH2 domain superfamily;IPR016251,Tyrosine-protein kinase, non-receptor Jak/Tyk2;IPR000299,FERM domain;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR000980,SH2 domain;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR020776,Tyrosine-protein kinase, non-receptor Jak1;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0197,Tyrosine kinases","GO:0038083,biological_process,peptidyl-tyrosine autophosphorylation;GO:0005102,molecular_function,signaling receptor binding;GO:0030154,biological_process,cell differentiation;GO:0005856,cellular_component,cytoskeleton;GO:0004672,molecular_function,protein kinase activity;GO:0005634,cellular_component,nucleus;GO:0016301,molecular_function,kinase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0005524,molecular_function,ATP binding;GO:0042127,biological_process,regulation of cell proliferation;GO:0016310,biological_process,phosphorylation;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016740,molecular_function,transferase activity;GO:0004715,molecular_function,non-membrane spanning protein tyrosine kinase activity;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0016020,cellular_component,membrane;GO:0038110,biological_process,interleukin-2-mediated signaling pathway;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0019903,molecular_function,protein phosphatase binding;GO:0045087,biological_process,innate immune response;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:1903672,biological_process,positive regulation of sprouting angiogenesis;GO:0046677,biological_process,response to antibiotic;GO:0031234,cellular_component,extrinsic component of cytoplasmic side of plasma membrane;GO:0016477,biological_process,cell migration","K11217,ko04550,Signaling pathways regulating pluripotency of stem cells;K11217,ko05160,Hepatitis C;K11217,ko05161,Hepatitis B;K11217,ko04151,PI3K-Akt signaling pathway;K11217,ko04380,Osteoclast differentiation;K11217,ko05169,Epstein-Barr virus infection;K11217,ko05140,Leishmaniasis;K11217,ko05162,Measles;K11217,ko05164,Influenza A;K11217,ko05152,Tuberculosis;K11217,ko04630,Jak-STAT signaling pathway;K11217,ko05166,HTLV-I infection;K11217,ko05200,Pathways in cancer;K11217,ko05168,Herpes simplex infection;K11217,ko01521,EGFR tyrosine kinase inhibitor resistance;K11217,ko05212,Pancreatic cancer;K11217,ko05145,Toxoplasmosis;K11217,ko05203,Viral carcinogenesis"]
["AC079305.10",72.33254926,17.07264443,2.078516423,4.541456577,{"v":3.25e-09,"d":"3.25E-09"},{"v":2.66E-8,"d":"2.66E-08"},"-","-","-","-","-","-","-","-"]
["UBE2Q1-AS1",288.5800377,68.26321772,2.078506523,6.288009228,1.31E-15,{"v":4.62e-14,"d":"4.62E-14"},"-","-","-","-","-","-","-","-"]
["AC027612.1",18.59764271,4.381364118,2.077431024,3.693909222,{"v":1.7E-6,"d":"1.70E-06"},{"v":7.69e-06,"d":"7.69E-06"},"ENSG00000232531","H9F7X8,Histone-lysine N-methyltransferase","-","PF00856,SET domain","IPR001214,SET domain;IPR016858,Class V SAM-dependent methyltransferases","COG2940,Proteins containing SET domain;KOG1085,Predicted methyltransferase (contains a SET domain)","GO:0032259,biological_process,methylation;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0034968,biological_process,histone lysine methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0016740,molecular_function,transferase activity","-"]
["SAMD4B",11.17008751,2.643431045,2.077378868,5.825159623,{"v":3.97e-14,"d":"3.97E-14"},{"v":9.91e-13,"d":"9.91E-13"},"ENSG00000179134","K7DRE0,Sterile alpha motif domain containing 4B","XP_016791400.1,-;XP_016791397.1,-;XP_016791398.1,-;XP_016791399.1,-;XP_016791402.1,-;XP_016791403.1,-;XP_016791401.1,-","PF00536,SAM domain (Sterile alpha motif)","IPR037634,Protein Smaug, SAM domain;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","ENOG410XSUP,-;KOG3791,Predicted RNA-binding protein involved in translational regulation","GO:0003723,molecular_function,RNA binding;GO:0005829,cellular_component,cytosol;GO:0043488,biological_process,regulation of mRNA stability;GO:0017148,biological_process,negative regulation of translation;GO:0030371,molecular_function,translation repressor activity","-"]
["RP11-507K12.1",37.67817803,8.928666116,2.076008883,6.377868735,{"v":6.99e-16,"d":"6.99E-16"},{"v":2.62e-14,"d":"2.62E-14"},"ENSG00000283321","A0A1B0GVI7,Uncharacterized protein","-","PF08447,PAS fold;PF00010,Helix-loop-helix DNA-binding domain;PF00989,PAS fold","IPR000014,PAS domain;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR035965,PAS domain superfamily;IPR013655,PAS fold-3;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR013767,PAS fold;IPR033348,Aryl hydrocarbon receptor;IPR001610,PAC motif","-","GO:0046983,molecular_function,protein dimerization activity;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:0034751,cellular_component,aryl hydrocarbon receptor complex;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0009410,biological_process,response to xenobiotic stimulus;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0004874,molecular_function,aryl hydrocarbon receptor activity;GO:0005634,cellular_component,nucleus","-"]
["ZSWIM8-AS1",7.644264951,1.795416137,2.075681358,2.950377626,{"v":9.87E-5,"d":"9.87E-05"},0.000298801,"ENSG00000272589","A0A096P4L8,Zinc finger SWIM-type containing 8","-","-","IPR007527,Zinc finger, SWIM-type","-","GO:0008270,molecular_function,zinc ion binding","-"]
["RAP2A",2.003703201,0.47061177,2.075681358,2.950377626,{"v":9.87E-5,"d":"9.87E-05"},0.000298801,"ENSG00000125249","G1PH24,RAP2A, member of RAS oncogene family","XP_006102004.1,-","PF00071,Ras family","IPR020849,Small GTPase superfamily, Ras type;IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1100,GTPase SAR1 and related small G proteins;KOG0395,Ras-related GTPase","GO:0048814,biological_process,regulation of dendrite morphogenesis;GO:0045184,biological_process,establishment of protein localization;GO:0019003,molecular_function,GDP binding;GO:0035690,biological_process,cellular response to drug;GO:0005525,molecular_function,GTP binding;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0055037,cellular_component,recycling endosome;GO:0055038,cellular_component,recycling endosome membrane;GO:0072659,biological_process,protein localization to plasma membrane;GO:0034613,biological_process,cellular protein localization;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0031954,biological_process,positive regulation of protein autophosphorylation;GO:0046328,biological_process,regulation of JNK cascade;GO:0000287,molecular_function,magnesium ion binding;GO:0000166,molecular_function,nucleotide binding;GO:0030033,biological_process,microvillus assembly;GO:0001934,biological_process,positive regulation of protein phosphorylation","-"]
["SLC22A23",1.254284876,0.294595141,2.075681358,2.950377626,{"v":9.87E-5,"d":"9.87E-05"},0.000298801,"ENSG00000137266","C9J4Z0,Solute carrier family 22 member 23","-","PF00083,Sugar (and other) transporter","IPR036259,MFS transporter superfamily;IPR020846,Major facilitator superfamily domain;IPR005829,Sugar transporter, conserved site;IPR005828,Major facilitator,  sugar transporter-like","KOG0255,Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily);ENOG410ZZ6M,-","GO:0055085,biological_process,transmembrane transport;GO:0022857,molecular_function,transmembrane transporter activity;GO:0005215,molecular_function,transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SESN2",11.62199958,2.751879498,2.074389491,4.689653043,6.29E-10,{"v":6.08e-09,"d":"6.08E-09"},"ENSG00000130766","K7C5U8,Sestrin 2","-","PF04636,PA26 p53-induced protein (sestrin)","IPR029032,AhpD-like;IPR006730,Sestrin","KOG3746,Uncharacterized conserved protein;ENOG410XP7Z,-","GO:1901031,biological_process,regulation of response to reactive oxygen species;GO:0005634,cellular_component,nucleus","-"]
["SCYL1",30.61139659,7.269506605,2.072923903,6.360486681,{"v":9.21e-16,"d":"9.21E-16"},{"v":3.35e-14,"d":"3.35E-14"},"ENSG00000142186","K7BMJ5,SCY1-like 1","XP_016776739.1,N-terminal kinase-like protein isoform X1","PF00069,Protein kinase domain","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","KOG1243,Protein kinase;ENOG410XQTG,-","GO:0005794,cellular_component,Golgi apparatus;GO:0030126,cellular_component,COPI vesicle coat;GO:0005737,cellular_component,cytoplasm;GO:0005793,cellular_component,endoplasmic reticulum-Golgi intermediate compartment;GO:0004672,molecular_function,protein kinase activity;GO:0006890,biological_process,retrograde vesicle-mediated transport, Golgi to ER;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0005801,cellular_component,cis-Golgi network;GO:0005524,molecular_function,ATP binding","-"]
["CAD",4.595820907,1.089358402,2.072723836,4.639612497,{"v":1.07E-9,"d":"1.07E-09"},{"v":9.8e-09,"d":"9.80E-09"},"ENSG00000084774","H2QHM0,Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase","XP_001155357.1,CAD protein isoform X4","PF02787,Carbamoyl-phosphate synthetase large chain, oligomerisation domain;PF00988,Carbamoyl-phosphate synthase small chain, CPSase domain;PF00117,lutamine amidotransferase class-I;PF02142,MGS-like domain;PF02729,Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;PF02786,Carbamoyl-phosphate synthase L chain, ATP binding domain;PF00185,Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;PF01979,Amidohydrolase family","IPR005479,Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain;IPR032466,Metal-dependent hydrolase;IPR016185,Pre-ATP-grasp domain superfamily;IPR006274,Carbamoyl-phosphate synthase, small subunit;IPR011059,Metal-dependent hydrolase, composite domain superfamily;IPR005483,Carbamoyl-phosphate synthase large subunit, CPSase domain;IPR035686,Carbamoyl-phosphate synthase small subunit, GATase1 domain;IPR036480,Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily;IPR002474,Carbamoyl-phosphate synthase small subunit, N-terminal domain;IPR029062,Class I glutamine amidotransferase-like;IPR006131,Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain;IPR036897,Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily;IPR006132,Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding;IPR005480,Carbamoyl-phosphate synthetase, large subunit oligomerisation domain;IPR017926,Glutamine amidotransferase;IPR002082,Aspartate carbamoyltransferase;IPR036914,Methylglyoxal synthase-like domain superfamily;IPR011761,ATP-grasp fold;IPR006130,Aspartate/ornithine carbamoyltransferase;IPR013815,ATP-grasp fold, subdomain 1;IPR006680,Amidohydrolase-related;IPR006275,Carbamoyl-phosphate synthase, large subunit;IPR002195,Dihydroorotase, conserved site;IPR036901,Aspartate/ornithine carbamoyltransferase superfamily;IPR011607,Methylglyoxal synthase-like domain","COG0458,Carbamoylphosphate synthase large subunit (split gene in MJ);KOG0370,Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase);COG0505,Carbamoylphosphate synthase small subunit;COG0540,Aspartate carbamoyltransferase, catalytic chain","GO:0016743,molecular_function,carboxyl- or carbamoyltransferase activity;GO:0016787,molecular_function,hydrolase activity;GO:0006520,biological_process,cellular amino acid metabolic process;GO:0004087,molecular_function,carbamoyl-phosphate synthase (ammonia) activity;GO:0006207,biological_process,'de novo' pyrimidine nucleobase biosynthetic process;GO:0005737,cellular_component,cytoplasm;GO:0016812,molecular_function,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0004088,molecular_function,carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0016810,molecular_function,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0004070,molecular_function,aspartate carbamoyltransferase activity;GO:0046872,molecular_function,metal ion binding;GO:0016597,molecular_function,amino acid binding;GO:0006807,biological_process,nitrogen compound metabolic process;GO:0000050,biological_process,urea cycle;GO:0006526,biological_process,arginine biosynthetic process;GO:0006541,biological_process,glutamine metabolic process;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004151,molecular_function,dihydroorotase activity","K11540,ko00250,Alanine, aspartate and glutamate metabolism;K11540,ko00240,Pyrimidine metabolism"]
["ITFG2",8.396590737,1.992193746,2.072408942,5.065099262,{"v":2.75e-11,"d":"2.75E-11"},{"v":3.6E-10,"d":"3.60E-10"},"ENSG00000111203","G2HGW5,Integrin alpha FG-GAP repeat containing 2","NP_001267257.1,-;XP_016778054.1,-","PF15907,Integrin-alpha FG-GAP repeat-containing protein 2","IPR031793,Integrin-alpha FG-GAP repeat-containing protein 2;IPR036322,WD40-repeat-containing domain superfamily","ENOG410XPME,-;ENOG410IEQ3,-","GO:0042149,biological_process,cellular response to glucose starvation;GO:0002314,biological_process,germinal center B cell differentiation;GO:0034198,biological_process,cellular response to amino acid starvation;GO:0140007,cellular_component,KICSTOR complex;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0005829,cellular_component,cytosol;GO:1904262,biological_process,negative regulation of TORC1 signaling;GO:0005765,cellular_component,lysosomal membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["ANO6",15.22513136,3.620810383,2.070801706,6.297558335,{"v":1.34e-15,"d":"1.34E-15"},{"v":4.73e-14,"d":"4.73E-14"},"ENSG00000177119","H2Q5R7,Anoctamin","XP_509014.3,anoctamin-6 isoform X2","PF16178,imerisation domain of Ca+-activated chloride-channel, anoctamin;PF04547,Calcium-activated chloride channel","IPR007632,Anoctamin;IPR032394,Anoctamin, dimerisation domain;IPR031295,Anoctamin-6","KOG2514,Uncharacterized conserved protein;ENOG410XS4S,-","GO:0046983,molecular_function,protein dimerization activity;GO:1902476,biological_process,chloride transmembrane transport;GO:0007596,biological_process,blood coagulation;GO:0030501,biological_process,positive regulation of bone mineralization;GO:0016020,cellular_component,membrane;GO:0061588,biological_process,calcium activated phospholipid scrambling;GO:0002407,biological_process,dendritic cell chemotaxis;GO:0016021,cellular_component,integral component of membrane;GO:0034767,biological_process,positive regulation of ion transmembrane transport","-"]
["EARS2",4.102714552,0.972125404,2.070587842,3.951691923,{"v":3.22E-7,"d":"3.22E-07"},{"v":1.68E-6,"d":"1.68E-06"},"ENSG00000103356","H3BTB7,Probable glutamate--tRNA ligase, mitochondrial","-","PF00749,tRNA synthetases class I (E and Q), catalytic domain","IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR020058,Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain;IPR008925,Aminoacyl-tRNA synthetase, class I, anticodon-binding;IPR004527,Glutamate-tRNA ligase, bacterial/mitochondrial;IPR000924,Glutamyl/glutaminyl-tRNA synthetase;IPR033910,Glutamyl-tRNA synthetase;IPR001412,Aminoacyl-tRNA synthetase, class I, conserved site","COG0008,Glutamyl- and glutaminyl-tRNA synthetases;KOG1149,Glutamyl-tRNA synthetase (mitochondrial)","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0006424,biological_process,glutamyl-tRNA aminoacylation;GO:0004818,molecular_function,glutamate-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0006412,biological_process,translation;GO:0016874,molecular_function,ligase activity;GO:0000049,molecular_function,tRNA binding;GO:0043039,biological_process,tRNA aminoacylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0008270,molecular_function,zinc ion binding","-"]
["XXYLT1",4.346192343,1.029816707,2.070587842,3.951691923,{"v":3.22E-7,"d":"3.22E-07"},{"v":1.68E-6,"d":"1.68E-06"},"ENSG00000173950","H2QP04,Chromosome 3 open reading frame 21","XP_516961.3,xyloside xylosyltransferase 1 isoform X1","PF01501,lycosyl transferase family 8","IPR029044,Nucleotide-diphospho-sugar transferases;IPR002495,Glycosyl transferase, family 8","ENOG410XRNY,-;KOG3765,Predicted glycosyltransferase","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016021,cellular_component,integral component of membrane;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0035252,molecular_function,UDP-xylosyltransferase activity;GO:0016266,biological_process,O-glycan processing;GO:0000287,molecular_function,magnesium ion binding;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane;GO:0030145,molecular_function,manganese ion binding","-"]
["HN1L",65.83941109,15.66847011,2.07058074,7.610300851,{"v":5.76e-19,"d":"5.76E-19"},{"v":3.84e-17,"d":"3.84E-17"},"ENSG00000206053","G3QTN5,Jupiter microtubule associated homolog 2","XP_004057006.1,hematological and neurological expressed 1-like protein isoform X2","-","IPR033335,Microtubule-associated protein Jupiter","-","GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane","-"]
["ELMO2",2.519280111,0.595932304,2.070201164,3.481310894,{"v":4.56e-06,"d":"4.56E-06"},{"v":1.87e-05,"d":"1.87E-05"},"ENSG00000062598","H2QKI4,Engulfment and cell motility 2","XP_016793523.1,-;XP_009435603.1,-;XP_009435605.1,-","PF16457,Pleckstrin homology domain;PF11841,omain of unknown function (DUF3361);PF04727,LMO/CED-12 family","IPR024574,Domain of unknown function DUF3361;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR006816,ELMO domain;IPR016024,Armadillo-type fold;IPR030713,Engulfment and cell motility protein 2;IPR011989,Armadillo-like helical","ENOG410XPKN,-;KOG2999,Regulator of Rac1, required for phagocytosis and cell migration","GO:0060326,biological_process,cell chemotaxis;GO:0098609,biological_process,cell-cell adhesion;GO:0007010,biological_process,cytoskeleton organization;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0030971,molecular_function,receptor tyrosine kinase binding;GO:0016477,biological_process,cell migration","-"]
["FAM83G",13.98952608,3.32822189,2.070081029,6.113815725,{"v":5.72e-15,"d":"5.72E-15"},{"v":1.74e-13,"d":"1.74E-13"},"ENSG00000188522","K7B029,Family with sequence similarity 83, member G","-","PF07894,Protein of unknown function (DUF1669)","IPR012461,FAM83","ENOG410YAC2,-;ENOG410IJIT,-","GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0030509,biological_process,BMP signaling pathway","-"]
["IRS1",4.294466608,1.02055328,2.069408258,4.778468564,{"v":4.98e-10,"d":"4.98E-10"},{"v":4.93e-09,"d":"4.93E-09"},"ENSG00000169047","A0A024R499,Insulin receptor substrate 1, isoform CRA_a","NP_005535.1,insulin receptor substrate 1","PF02174,PTB domain (IRS-1 type);PF00169,PH domain","IPR002404,IRS-type PTB domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","ENOG410Z9EP,-;ENOG410IXEK,-","GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane;GO:0005634,cellular_component,nucleus","K16172,ko04910,Insulin signaling pathway;K16172,ko04920,Adipocytokine signaling pathway;K16172,ko04213,Longevity regulating pathway - multiple species;K16172,ko04930,Type II diabetes mellitus;K16172,ko05206,MicroRNAs in cancer;K16172,ko04068,FoxO signaling pathway;K16172,ko04923,Regulation of lipolysis in adipocytes;K16172,ko04932,Non-alcoholic fatty liver disease (NAFLD);K16172,ko04722,Neurotrophin signaling pathway;K16172,ko04151,PI3K-Akt signaling pathway;K16172,ko04022,cGMP-PKG signaling pathway;K16172,ko04211,Longevity regulating pathway;K16172,ko04150,mTOR signaling pathway;K16172,ko04960,Aldosterone-regulated sodium reabsorption;K16172,ko04931,Insulin resistance;K16172,ko04152,AMPK signaling pathway;K16172,ko04212,Longevity regulating pathway - worm"]
["UBIAD1",1.915754812,0.451327059,2.069269831,2.772795485,0.000287197,7.86164E-4,"ENSG00000120942","G3QG04,UbiA prenyltransferase domain containing 1","XP_004024691.1,-","PF01040,UbiA prenyltransferase family","IPR000537,UbiA prenyltransferase family;IPR026046,UbiA prenyltransferase domain containing protein 1","-","GO:0009234,biological_process,menaquinone biosynthetic process;GO:0016209,molecular_function,antioxidant activity;GO:0006744,biological_process,ubiquinone biosynthetic process;GO:0030173,cellular_component,integral component of Golgi membrane;GO:0016765,molecular_function,transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0005737,cellular_component,cytoplasm;GO:0004659,molecular_function,prenyltransferase activity;GO:0042371,biological_process,vitamin K biosynthetic process;GO:0098869,biological_process,cellular oxidant detoxification;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","-"]
["STAMBPL1",1.539754224,0.362746183,2.069269831,2.772795485,0.000287197,7.86164E-4,"ENSG00000138134","G1RNN2,STAM binding protein like 1","-","PF01398,JAB1/Mov34/MPN/PAD-1 ubiquitin protease;PF08969,USP8 dimerisation domain","IPR037518,MPN domain;IPR015063,USP8 dimerisation domain;IPR000555,JAB1/MPN/MOV34 metalloenzyme domain","KOG2880,SMAD6 interacting protein AMSH, contains JAB/MPN/Mov34 domain;COG1310,Predicted metal-dependent protease of the PAD1/JAB1 superfamily","-","-"]
["ALG12",1.819788029,0.428718526,2.069269831,2.772795485,0.000287197,7.86164E-4,"ENSG00000182858","A0A024R4V6,Mannosyltransferase","NP_077010.1,Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase","PF03901,Alg9-like mannosyltransferase family","IPR005599,GPI mannosyltransferase","KOG2516,Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family);ENOG410XR38,-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane","K03847,ko00513,Various types of N-glycan biosynthesis;K03847,ko00510,N-Glycan biosynthesis"]
["DENND6A-AS1",26.7468845,6.301220098,2.069269831,2.772795485,0.000287197,7.86164E-4,"-","-","-","-","-","-","-","-"]
["ZNF488",10.25643076,2.436856285,2.069002751,4.533962739,{"v":3.25e-09,"d":"3.25E-09"},{"v":2.66E-8,"d":"2.66E-08"},"ENSG00000265763","G1RZR8,Zinc finger protein 488","-","-","-","-","-","-"]
["MBOAT2",6.261736043,1.489717868,2.068640834,5.133967752,1.45E-11,2.02E-10,"ENSG00000143797","K7D3A7,Membrane bound O-acyltransferase domain containing 2","XP_016802206.1,lysophospholipid acyltransferase 2 isoform X1","PF03062,MBOAT, membrane-bound O-acyltransferase family","IPR004299,Membrane bound O-acyl transferase, MBOAT","KOG2704,Predicted membrane protein;COG5202,Predicted membrane protein","GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016740,molecular_function,transferase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K13517,ko00564,Glycerophospholipid metabolism;K13517,ko00561,Glycerolipid metabolism"]
["BCAR3",9.560573085,2.274537996,2.068229779,4.946779387,{"v":7.3e-11,"d":"7.30E-11"},{"v":8.57e-10,"d":"8.57E-10"},"ENSG00000137936","B3KP06,cDNA FLJ30880 fis, clone FEBRA2004767, highly similar to Breast cancer anti-estrogen resistance protein 3","NP_001248338.1,-","PF00017,SH2 domain;PF00617,RasGEF domain","IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR028849,Breast cancer anti-estrogen resistance protein 3;IPR036860,SH2 domain superfamily;IPR000980,SH2 domain;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily","ENOG410IFQG,-;ENOG410XTJR,-","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0007165,biological_process,signal transduction;GO:0005622,cellular_component,intracellular","-"]
["SLC39A10",23.65332371,5.637118688,2.068043571,6.677676107,1.04E-16,{"v":4.5e-15,"d":"4.50E-15"},"ENSG00000196950","H2QJ63,Solute carrier family 39","-","PF02535,ZIP Zinc transporter","IPR003689,Zinc/iron permease","KOG2693,Putative zinc transporter;COG0428,Predicted divalent heavy-metal cations transporter","GO:0030001,biological_process,metal ion transport;GO:0055085,biological_process,transmembrane transport;GO:0071578,biological_process,zinc ion import across plasma membrane;GO:0006882,biological_process,cellular zinc ion homeostasis;GO:0016020,cellular_component,membrane;GO:0050861,biological_process,positive regulation of B cell receptor signaling pathway;GO:0005887,cellular_component,integral component of plasma membrane;GO:0005385,molecular_function,zinc ion transmembrane transporter activity;GO:0046873,molecular_function,metal ion transmembrane transporter activity","-"]
["CTDSPL",10.44726312,2.487438161,2.067772075,5.267036036,{"v":5.04e-12,"d":"5.04E-12"},{"v":7.7e-11,"d":"7.70E-11"},"ENSG00000144677","H2R387,CTD","-","PF03031,NLI interacting factor-like phosphatase","IPR004274,FCP1 homology domain;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR011948,Dullard phosphatase domain, eukaryotic","KOG1605,TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation);COG5190,TFIIF-interacting CTD phosphatases, including NLI-interacting factor","GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0016791,molecular_function,phosphatase activity","-"]
["RASAL2",13.70531629,3.267648418,2.067689879,7.100518126,{"v":9.22e-18,"d":"9.22E-18"},{"v":5e-16,"d":"5.00E-16"},"ENSG00000075391","K6ZKJ3,RAS protein activator like 2","XP_001154236.3,ras GTPase-activating protein nGAP isoform X4","PF12004,omain of unknown function (DUF3498);PF00616,TPase-activator protein for Ras-like GTPase;PF00168,C2 domain","IPR001936,Ras GTPase-activating domain;IPR001849,Pleckstrin homology domain;IPR021887,Domain of unknown function DUF3498;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR008936,Rho GTPase activation protein;IPR023152,Ras GTPase-activating protein, conserved site","KOG3508,GTPase-activating protein;ENOG410XPU1,-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0043087,biological_process,regulation of GTPase activity;GO:0007165,biological_process,signal transduction;GO:0005096,molecular_function,GTPase activator activity","-"]
["NT5DC2",8.755682407,2.083047966,2.067682002,4.731481808,{"v":4.67e-10,"d":"4.67E-10"},{"v":4.65e-09,"d":"4.65E-09"},"ENSG00000168268","K7CWR4,5'-nucleotidase domain containing 2","XP_009443870.2,5'-nucleotidase domain-containing protein 2 isoform X1","PF05761,5' nucleotidase family","IPR008380,HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR016695,Purine 5'-nucleotidase","KOG2470,Similar to IMP-GMP specific 5'-nucleotidase;ENOG410XT8W,-","GO:0046872,molecular_function,metal ion binding","-"]
["PSG1",4.451480248,1.056765797,2.0674353,3.866827375,{"v":3.47e-07,"d":"3.47E-07"},{"v":1.8e-06,"d":"1.80E-06"},"ENSG00000231924","Q96QL5,PSG4 protein","NP_998798.1,pregnancy-specific beta-1-glycoprotein 4 isoform 2 precursor;NP_001263424.1,pregnancy-specific beta-1-glycoprotein 4 isoform 3 precursor;NP_002771.2,pregnancy-specific beta-1-glycoprotein 4 isoform 1 precursor;NP_001303268.1,pregnancy-specific beta-1-glycoprotein 4 isoform 4","PF13927,Immunoglobulin domain;PF07686,Immunoglobulin V-set domain;PF13895,Immunoglobulin domain","IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain","ENOG410JG1N,-;ENOG410YTW2,-","-","-"]
["NUPL2",5.058129526,1.200782208,2.0674353,3.866827375,{"v":3.47e-07,"d":"3.47E-07"},{"v":1.8e-06,"d":"1.80E-06"},"ENSG00000136243","C9JYA1,Nucleoporin-like protein 2","-","-","IPR000571,Zinc finger, CCCH-type","-","GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["DGKA",8.345393261,1.988755124,2.067254462,5.7501972,{"v":1.16e-13,"d":"1.16E-13"},2.61E-12,"ENSG00000065357","H2Q668,Diacylglycerol kinase","XP_001169946.1,-;XP_001169972.1,-;XP_001169899.1,-;XP_001169923.1,-","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF00781,iacylglycerol kinase catalytic domain;PF00609,iacylglycerol kinase accessory domain;PF14513,iacylglycerol kinase N-terminus","IPR017438,Inorganic polyphosphate/ATP-NAD kinase, N-terminal;IPR018247,EF-Hand 1, calcium-binding site;IPR000756,Diacylglycerol kinase, accessory domain;IPR001206,Diacylglycerol kinase, catalytic domain;IPR011992,EF-hand domain pair;IPR029477,Diacylglycerol kinase type I, N-terminal;IPR002048,EF-hand domain;IPR038199,DGK type I, N-terminal domain superfamily;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR016064,NAD kinase/diacylglycerol kinase-like domain superfamily;IPR037607,Diacylglycerol kinase","ENOG410XQVB,-;KOG1169,Diacylglycerol kinase","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0004143,molecular_function,diacylglycerol kinase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0007205,biological_process,protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0016740,molecular_function,transferase activity;GO:0005509,molecular_function,calcium ion binding;GO:0007165,biological_process,signal transduction;GO:0008152,biological_process,metabolic process;GO:0005622,cellular_component,intracellular;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0003951,molecular_function,NAD+ kinase activity","K00901,ko00561,Glycerolipid metabolism;K00901,ko05231,Choline metabolism in cancer;K00901,ko04070,Phosphatidylinositol signaling system;K00901,ko04072,Phospholipase D signaling pathway;K00901,ko00564,Glycerophospholipid metabolism"]
["HUWE1",20.46693312,4.882901742,2.067038854,7.790372065,{"v":2.72e-19,"d":"2.72E-19"},{"v":1.98e-17,"d":"1.98E-17"},"ENSG00000086758","A0A024R9W5,HECT, UBA and WWE domain containing 1, isoform CRA_b","NP_113584.3,E3 ubiquitin-protein ligase HUWE1;XP_005262022.1,-","PF00627,UBA/TS-N domain;PF06012,omain of Unknown Function (DUF908);PF14377,omain of unknown function (DUF4414);PF06025,omain of Unknown Function (DUF913);PF00632,HECT-domain (ubiquitin-transferase);PF02825,WWE domain","IPR037197,WWE domain superfamily;IPR004170,WWE domain;IPR009060,UBA-like superfamily;IPR010309,E3 ubiquitin ligase, domain of unknown function DUF908;IPR015940,Ubiquitin-associated domain;IPR010314,E3 ubiquitin ligase, domain of unknown function DUF913;IPR016024,Armadillo-type fold;IPR025527,Domain of unknown function DUF4414;IPR035983,HECT, E3 ligase catalytic domain;IPR000569,HECT domain","KOG0939,E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein;COG5021,Ubiquitin-protein ligase","GO:0005829,cellular_component,cytosol;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016567,biological_process,protein ubiquitination;GO:0016740,molecular_function,transferase activity;GO:0005654,cellular_component,nucleoplasm","K10592,ko04120,Ubiquitin mediated proteolysis"]
["WHSC1",21.16920692,5.053466361,2.066243797,8.024477861,1.13E-19,{"v":8.85e-18,"d":"8.85E-18"},"ENSG00000109685","H2QP41,Histone-lysine N-methyltransferase","XP_016806630.1,-;XP_016806632.1,-;XP_009445510.1,-;XP_016806631.1,-;XP_009445509.1,-","PF00505,HMG (high mobility group) box;PF00856,SET domain;PF00855,PWWP domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR001214,SET domain;IPR009071,High mobility group box domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR006560,AWS domain;IPR001841,Zinc finger, RING-type;IPR019787,Zinc finger, PHD-finger;IPR000313,PWWP domain;IPR036910,High mobility group box domain superfamily;IPR003616,Post-SET domain;IPR019786,Zinc finger, PHD-type, conserved site","COG2940,Proteins containing SET domain;KOG1081,Transcription factor NSD1 and related SET domain proteins","GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0048298,biological_process,positive regulation of isotype switching to IgA isotypes;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003289,biological_process,atrial septum primum morphogenesis;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0010452,biological_process,histone H3-K36 methylation;GO:0070201,biological_process,regulation of establishment of protein localization;GO:0003149,biological_process,membranous septum morphogenesis;GO:0034770,biological_process,histone H4-K20 methylation;GO:0032259,biological_process,methylation;GO:0060348,biological_process,bone development;GO:0003290,biological_process,atrial septum secundum morphogenesis;GO:2001032,biological_process,regulation of double-strand break repair via nonhomologous end joining;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding;GO:0008168,molecular_function,methyltransferase activity","-"]
["KCTD11",4.972987336,1.179416851,2.065590788,3.361739773,{"v":1.13E-5,"d":"1.13E-05"},{"v":4.24e-05,"d":"4.24E-05"},"ENSG00000213859","G3RRD5,Uncharacterized protein","XP_004058524.1,-;XP_004058519.1,-","PF02214,BTB/POZ domain","IPR003131,Potassium channel tetramerisation-type BTB domain;IPR011333,SKP1/BTB/POZ domain superfamily","-","GO:0051260,biological_process,protein homooligomerization","-"]
["CAPN7",3.690430982,0.877983508,2.063857005,3.776584207,{"v":7.58e-07,"d":"7.58E-07"},{"v":3.67E-6,"d":"3.67E-06"},"ENSG00000131375","B2RAM2,cDNA, FLJ94999, highly similar to Homo sapiens calpain 7","-","PF04212,MIT (microtubule interacting and transport) domain;PF01067,Calpain large subunit, domain III;PF00648,Calpain family cysteine protease","IPR007330,MIT;IPR001300,Peptidase C2, calpain, catalytic domain;IPR022684,Peptidase C2, calpain family;IPR022683,Peptidase C2, calpain, domain III;IPR036213,Calpain large subunit, domain III superfamily;IPR022682,Peptidase C2, calpain, large subunit, domain III;IPR036181,MIT domain superfamily;IPR033883,Calpain subdomain III","KOG0045,Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily);ENOG410XP0B,-","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0005622,cellular_component,intracellular;GO:0004198,molecular_function,calcium-dependent cysteine-type endopeptidase activity;GO:0008233,molecular_function,peptidase activity","-"]
["RP11-363E6.3",29.47080262,7.011343333,2.063857005,3.776584207,{"v":7.58e-07,"d":"7.58E-07"},{"v":3.67E-6,"d":"3.67E-06"},"-","-","-","-","-","-","-","-"]
["NUTM2A-AS1",3.812672016,0.908714853,2.062848264,4.097434009,{"v":1e-07,"d":"1.00E-07"},{"v":5.86e-07,"d":"5.86E-07"},"ENSG00000223482","J9PA88,Uncharacterized protein","-","-","-","-","-","-"]
["MTMR4",4.955689989,1.183533514,2.061723134,4.580508171,{"v":2.33E-9,"d":"2.33E-09"},{"v":1.98e-08,"d":"1.98E-08"},"ENSG00000108389","H2QDJ2,Myotubularin related protein 4","XP_511909.3,myotubularin-related protein 4 isoform X2;XP_009431195.1,-;XP_009431194.1,-","PF06602,Myotubularin-like phosphatase domain;PF01363,YVE zinc finger","IPR017455,Zinc finger, FYVE-related;IPR029021,Protein-tyrosine phosphatase-like;IPR030590,Myotubularin-related protein 4;IPR000306,FYVE zinc finger;IPR035997,MTMR4, PH-GRAM domain;IPR016130,Protein-tyrosine phosphatase, active site;IPR010569,Myotubularin-like phosphatase domain;IPR011011,Zinc finger, FYVE/PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000387,Tyrosine specific protein phosphatases domain;IPR030564,Myotubularin family","ENOG410XPYG,-;ENOG410INM5,-","GO:0060304,biological_process,regulation of phosphatidylinositol dephosphorylation;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0005768,cellular_component,endosome;GO:0046872,molecular_function,metal ion binding;GO:0019903,molecular_function,protein phosphatase binding;GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0004722,molecular_function,protein serine/threonine phosphatase activity;GO:0016791,molecular_function,phosphatase activity","K18082,ko04070,Phosphatidylinositol signaling system;K18082,ko00562,Inositol phosphate metabolism"]
["QRICH1",24.39806912,5.839428554,2.061692335,6.395763685,{"v":7.42e-16,"d":"7.42E-16"},{"v":2.78e-14,"d":"2.78E-14"},"ENSG00000198218","H2R0N0,Glutamine-rich 1","XP_009443709.1,-;XP_016795377.1,-;XP_009443706.1,-;XP_009443711.1,-;XP_009443707.1,-;XP_009443710.1,-","PF12012,omain of unknown function (DUF3504)","IPR021893,Protein of unknown function DUF3504","ENOG410XQR6,-;ENOG410IE8I,-","GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0007010,biological_process,cytoskeleton organization;GO:0022604,biological_process,regulation of cell morphogenesis;GO:0007275,biological_process,multicellular organism development;GO:0005654,cellular_component,nucleoplasm","-"]
["TP53BP2",17.59844842,4.211331209,2.061604041,6.052763599,{"v":1.39e-14,"d":"1.39E-14"},{"v":3.85e-13,"d":"3.85E-13"},"ENSG00000143514","G1RSK7,Tumor protein p53 binding protein 2","XP_003275113.1,apoptosis-stimulating of p53 protein 2 isoform X1","PF12796,Ankyrin repeats (3 copies);PF00018,SH3 domain","IPR002110,Ankyrin repeat;IPR036028,SH3-like domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR001452,SH3 domain;IPR029071,Ubiquitin-like domain superfamily","KOG0515,p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains;ENOG410Y17W,-","-","K16823,ko04390,Hippo signaling pathway"]
["ANK3",1.659458343,0.396563083,2.061377424,4.772127859,{"v":4.98e-10,"d":"4.98E-10"},{"v":4.93e-09,"d":"4.93E-09"},"ENSG00000151150","G3QMX5,Ankyrin 3","XP_004049497.2,ankyrin-3 isoform X1","PF12796,Ankyrin repeats (3 copies);PF00791,ZU5 domain;PF13857,Ankyrin repeats (many copies);PF00531,eath domain;PF13637,Ankyrin repeats (many copies)","IPR000906,ZU5 domain;IPR002110,Ankyrin repeat;IPR011029,Death-like domain superfamily;IPR000488,Death domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR037971,Ankyrin-3, death domain","-","GO:0007165,biological_process,signal transduction","-"]
["PTPN23",8.933043419,2.136578224,2.060898041,5.092352167,{"v":2.64e-11,"d":"2.64E-11"},{"v":3.48e-10,"d":"3.48E-10"},"ENSG00000076201","H2PAW6,Protein tyrosine phosphatase, non-receptor type 23","-","PF13949,ALIX V-shaped domain binding to HIV;PF00102,Protein-tyrosine phosphatase;PF03097,BRO1-like domain","IPR029021,Protein-tyrosine phosphatase-like;IPR000242,PTP type protein phosphatase;IPR025304,ALIX V-shaped domain;IPR000387,Tyrosine specific protein phosphatases domain;IPR028770,Tyrosine-protein phosphatase non-receptor type 23;IPR038499,BRO1 domain superfamily;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR016130,Protein-tyrosine phosphatase, active site;IPR004328,BRO1 domain","KOG0789,Protein tyrosine phosphatase;ENOG410XQX6,-;KOG2220,Predicted signal transduction protein","GO:0019901,molecular_function,protein kinase binding;GO:0005769,cellular_component,early endosome;GO:0010633,biological_process,negative regulation of epithelial cell migration;GO:0016311,biological_process,dephosphorylation;GO:1903387,biological_process,positive regulation of homophilic cell adhesion;GO:0061357,biological_process,positive regulation of Wnt protein secretion;GO:0005634,cellular_component,nucleus;GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0005737,cellular_component,cytoplasm;GO:0016604,cellular_component,nuclear body;GO:0006470,biological_process,protein dephosphorylation;GO:2000643,biological_process,positive regulation of early endosome to late endosome transport;GO:0005829,cellular_component,cytosol;GO:0032456,biological_process,endocytic recycling;GO:0030334,biological_process,regulation of cell migration;GO:0036064,cellular_component,ciliary basal body;GO:0005768,cellular_component,endosome;GO:0045022,biological_process,early endosome to late endosome transport;GO:0060271,biological_process,cilium assembly;GO:0005654,cellular_component,nucleoplasm;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0043162,biological_process,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:1903393,biological_process,positive regulation of adherens junction organization;GO:0016791,molecular_function,phosphatase activity","-"]
["TMEM260",1.028984163,0.243404812,2.060713638,2.569547409,0.000877812,0.002140789,"ENSG00000070269","G3RHX4,Transmembrane protein 260","XP_004055258.2,transmembrane protein 260 isoform X1","PF11028,Protein of unknown function (DUF2723)","IPR021280,Protein of unknown function DUF2723","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CHST14",2.32543511,0.550078531,2.060713638,2.569547409,0.000877812,0.002140789,"ENSG00000169105","H2Q964,Carbohydrate sulfotransferase","XP_510310.2,carbohydrate sulfotransferase 14","PF03567,Sulfotransferase family","IPR018011,Carbohydrate sulfotransferase 8-10;IPR005331,Sulfotransferase","ENOG4111GJR,-;KOG4651,Chondroitin 6-sulfotransferase and related sulfotransferases","GO:0008146,molecular_function,sulfotransferase activity;GO:0005975,biological_process,carbohydrate metabolic process;GO:0005794,cellular_component,Golgi apparatus;GO:0016740,molecular_function,transferase activity;GO:0000139,cellular_component,Golgi membrane;GO:0016051,biological_process,carbohydrate biosynthetic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K08105,ko00532,Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate"]
["TYRO3",0.759351767,0.179623634,2.060713638,2.569547409,0.000877812,0.002140789,"ENSG00000092445","K7AIT8,TYRO3 protein tyrosine kinase","XP_016783467.1,tyrosine-protein kinase receptor TYRO3","PF07714,Protein tyrosine kinase;PF00041,ibronectin type III domain;PF07679,Immunoglobulin I-set domain","IPR013783,Immunoglobulin-like fold;IPR003961,Fibronectin type III;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR036116,Fibronectin type III superfamily;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR036179,Immunoglobulin-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR007110,Immunoglobulin-like domain;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;ENOG410IG6I,-","GO:0016301,molecular_function,kinase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0043548,molecular_function,phosphatidylinositol 3-kinase binding;GO:0016740,molecular_function,transferase activity;GO:0046777,biological_process,protein autophosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0016021,cellular_component,integral component of membrane","-"]
["MZF1",1.242131981,0.293824641,2.060713638,2.569547409,0.000877812,0.002140789,"ENSG00000099326","A0A024R4T5,Zinc finger protein 42","NP_932172.1,myeloid zinc finger 1 isoform 1;NP_003413.2,-","PF00096,Zinc finger, C2H2 type;PF02023,SCAN domain","IPR003309,SCAN domain;IPR013087,Zinc finger C2H2-type;IPR038269,SCAN domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["RPS6KA2",1.008262172,0.238503054,2.060713638,2.569547409,0.000877812,0.002140789,"ENSG00000071242","F2Z2J1,Ribosomal protein S6 kinase","-","PF00433,Protein kinase C terminal domain;PF00069,Protein kinase domain","IPR016239,Ribosomal protein S6 kinase II;IPR017892,Protein kinase, C-terminal;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XNPH,-;KOG0598,Ribosomal protein S6 kinase and related proteins","GO:0004672,molecular_function,protein kinase activity;GO:0045835,biological_process,negative regulation of meiotic nuclear division;GO:0005524,molecular_function,ATP binding;GO:0071322,biological_process,cellular response to carbohydrate stimulus;GO:0001556,biological_process,oocyte maturation;GO:0016301,molecular_function,kinase activity;GO:0007507,biological_process,heart development;GO:0060047,biological_process,heart contraction;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0016310,biological_process,phosphorylation;GO:0000287,molecular_function,magnesium ion binding;GO:0010628,biological_process,positive regulation of gene expression;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0070613,biological_process,regulation of protein processing;GO:0005819,cellular_component,spindle;GO:0004711,molecular_function,ribosomal protein S6 kinase activity;GO:0010659,biological_process,cardiac muscle cell apoptotic process;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0002035,biological_process,brain renin-angiotensin system","-"]
["LINC00346",2.198354098,0.523006297,2.060048455,3.231140838,{"v":4.05e-05,"d":"4.05E-05"},0.00013434,"ENSG00000255874","H2NKB8,Uncharacterized protein","XP_002824478.1,putative uncharacterized protein encoded by LINC00346","-","-","ENOG4110P0Y,-;ENOG410KCFE,-","-","-"]
["CTD-2196E14.5",21.4862534,5.111754213,2.060048455,3.231140838,{"v":4.05e-05,"d":"4.05E-05"},0.00013434,"ENSG00000261266","G2HFG8,Serine/threonine-protein kinase PLK","-","PF00069,Protein kinase domain;PF00659,POLO box duplicated region","IPR036947,POLO box domain superfamily;IPR033702,Polo-like kinase 1, catalytic domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR033701,First polo-box domain;IPR000959,POLO box domain;IPR033695,Second polo-box domain;IPR000719,Protein kinase domain","KOG0575,Polo-like serine/threonine protein kinase;ENOG410XQBP,-","GO:0016301,molecular_function,kinase activity;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["CTD-3193O13.12",2.906243601,0.69141896,2.060048455,3.231140838,{"v":4.05e-05,"d":"4.05E-05"},0.00013434,"ENSG00000214248","G3S403,Leucine rich repeat containing 8 family member E","XP_004059950.1,-;XP_004059949.1,volume-regulated anion channel subunit LRRC8E isoform X1","PF13855,Leucine rich repeat;PF12534,Pannexin-like TM region of LRRC8","IPR001611,Leucine-rich repeat;IPR021040,LRRC8, pannexin-like TM region;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","-","GO:0005225,molecular_function,volume-sensitive anion channel activity;GO:0005737,cellular_component,cytoplasm;GO:0098656,biological_process,anion transmembrane transport;GO:0015698,biological_process,inorganic anion transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["IAH1",2.331193031,0.554609758,2.060048455,3.231140838,{"v":4.05e-05,"d":"4.05E-05"},0.00013434,"ENSG00000134330","H2QHF0,Isoamyl acetate-hydrolyzing esterase 1 homolog","XP_001155422.3,-","PF13472,SL-like Lipase/Acylhydrolase family","IPR013830,SGNH hydrolase-type esterase domain;IPR036514,SGNH hydrolase superfamily","COG2755,Lysophospholipase L1 and related esterases;KOG3035,Isoamyl acetate-hydrolyzing esterase","-","-"]
["UTS2B",3.577321669,0.851073883,2.060048455,3.231140838,{"v":4.05e-05,"d":"4.05E-05"},0.00013434,"ENSG00000188958","F8WCV4,Urotensin-2B","XP_016861580.1,urotensin-2B isoform X1","-","-","ENOG410XXYD,-;ENOG410J14T,-","-","-"]
["C15orf41",3.953715373,0.945637648,2.059425926,4.526428778,{"v":4.11e-09,"d":"4.11E-09"},{"v":3.29e-08,"d":"3.29E-08"},"ENSG00000186073","H3BS01,Uncharacterized protein C15orf41","NP_001308690.1,uncharacterized protein C15orf41 isoform 7","PF14811,Protein of unknown function TPD sequence-motif","IPR029404,Protein of unknown function with TPD sequence-motif","ENOG410ZQKM,-;ENOG410IHV7,-","-","-"]
["DIP2B",6.073442573,1.454735882,2.059255326,5.322755786,{"v":5.55e-12,"d":"5.55E-12"},{"v":8.38e-11,"d":"8.38E-11"},"ENSG00000066084","F7H527,Disco-interacting protein 2 homolog B","XP_017831542.1,disco-interacting protein 2 homolog B isoform X3","PF06464,MAP1-binding Domain;PF00501,AMP-binding enzyme","IPR000873,AMP-dependent synthetase/ligase;IPR010506,DMAP1-binding domain","KOG3628,Predicted AMP-binding protein;COG0318,Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II","GO:0005737,cellular_component,cytoplasm;GO:0003824,molecular_function,catalytic activity;GO:0005634,cellular_component,nucleus;GO:0008152,biological_process,metabolic process","-"]
["TOM1L1",8.649750997,2.071823845,2.059255326,5.322755786,{"v":5.55e-12,"d":"5.55E-12"},{"v":8.38e-11,"d":"8.38E-11"},"ENSG00000141198","H2QDG7,Target of myb1","XP_009431131.1,TOM1-like protein 1 isoform X1","PF00790,VHS domain;PF03127,AT domain","IPR008942,ENTH/VHS;IPR038425,GAT domain superfamily;IPR002014,VHS domain;IPR014645,Target of Myb protein 1;IPR027428,TOM1-like protein 1;IPR004152,GAT domain","ENOG410Y26G,-;KOG1087,Cytosolic sorting protein GGA2/TOM1","GO:0019901,molecular_function,protein kinase binding;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0005622,cellular_component,intracellular;GO:0032147,biological_process,activation of protein kinase activity;GO:0005768,cellular_component,endosome;GO:0030295,molecular_function,protein kinase activator activity;GO:0007165,biological_process,signal transduction;GO:0031954,biological_process,positive regulation of protein autophosphorylation;GO:0005829,cellular_component,cytosol;GO:0045839,biological_process,negative regulation of mitotic nuclear division;GO:0030276,molecular_function,clathrin binding;GO:0006886,biological_process,intracellular protein transport","-"]
["DHTKD1",14.74851878,3.536606016,2.058113719,5.624052691,{"v":4.23e-13,"d":"4.23E-13"},{"v":8.41e-12,"d":"8.41E-12"},"ENSG00000181192","H2Q1M0,Dehydrogenase E1 and transketolase domain containing 1","-","PF02779,Transketolase, pyrimidine binding domain;PF16870,2-oxoglutarate dehydrogenase C-terminal;PF00676,ehydrogenase E1 component","IPR011603,2-oxoglutarate dehydrogenase E1 component;IPR001017,Dehydrogenase, E1 component;IPR029061,Thiamin diphosphate-binding fold;IPR005475,Transketolase-like, pyrimidine-binding domain;IPR031717,Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal","KOG0450,2-oxoglutarate dehydrogenase, E1 subunit;COG0567,2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes","GO:0004591,molecular_function,oxoglutarate dehydrogenase (succinyl-transferring) activity;GO:0030976,molecular_function,thiamine pyrophosphate binding;GO:0045252,cellular_component,oxoglutarate dehydrogenase complex;GO:0016624,molecular_function,oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0005829,cellular_component,cytosol;GO:0006099,biological_process,tricarboxylic acid cycle","-"]
["ZNF644",15.08327856,3.619638268,2.057662455,6.173214738,{"v":5.07e-15,"d":"5.07E-15"},{"v":1.56e-13,"d":"1.56E-13"},"ENSG00000122482","K7B3T0,Zinc finger protein 644","XP_016777788.1,zinc finger protein 644 isoform X2","PF13894,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["CLASP1",7.412572396,1.778846064,2.057114984,5.695742803,{"v":1.76e-13,"d":"1.76E-13"},{"v":3.79e-12,"d":"3.79E-12"},"ENSG00000074054","G3QZX5,Cytoplasmic linker associated protein 1","-","PF12348,CLASP N terminal","IPR028399,CLIP-associating protein 1;IPR011989,Armadillo-like helical;IPR021133,HEAT, type 2;IPR016024,Armadillo-type fold;IPR024395,CLASP N-terminal domain;IPR034085,TOG domain","-","GO:0005881,cellular_component,cytoplasmic microtubule;GO:0051010,molecular_function,microtubule plus-end binding;GO:0043515,molecular_function,kinetochore binding;GO:0005828,cellular_component,kinetochore microtubule","-"]
["LGALS8",7.31210952,1.754737296,2.056820332,5.493462828,{"v":1.3e-12,"d":"1.30E-12"},{"v":2.3e-11,"d":"2.30E-11"},"ENSG00000116977","A0A024R3X1,Galectin","-","PF00337,alactoside-binding lectin","IPR001079,Galectin, carbohydrate recognition domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR030638,Galectin-8","ENOG4111EA0,-;KOG3587,Galectin, galactose-binding lectin","GO:0030246,molecular_function,carbohydrate binding","-"]
["MBD1",3.45576095,0.827187194,2.055962589,3.940308211,{"v":4.27E-7,"d":"4.27E-07"},{"v":2.18e-06,"d":"2.18E-06"},"ENSG00000141644","K7CR55,Methyl-CpG binding domain protein 1","XP_003315950.1,methyl-CpG-binding domain protein 1 isoform X5","PF01429,Methyl-CpG binding domain;PF02008,CXXC zinc finger domain","IPR001739,Methyl-CpG DNA binding;IPR002857,Zinc finger, CXXC-type;IPR016177,DNA-binding domain superfamily","ENOG4111S3X,-;ENOG410IIBG,-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["LHFP",63.26828108,15.20741387,2.055642243,6.529378613,{"v":4.05e-16,"d":"4.05E-16"},1.59E-14,"ENSG00000183722","H2Q7G2,Lipoma HMGIC fusion partner","XP_016780705.1,-;XP_001147653.1,-","PF10242,Lipoma HMGIC fusion partner-like protein","IPR019372,Lipoma HMGIC fusion partner-like protein","KOG4026,Uncharacterized conserved protein;ENOG410XSUB,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP4-781K5.2",25.69914992,6.146644713,2.055024233,3.576863527,{"v":5.38e-06,"d":"5.38E-06"},{"v":2.17e-05,"d":"2.17E-05"},"ENSG00000228830","A0A087R6Y0,Interferon regulatory factor 2-binding protein 2","-","-","-","-","-","-"]
["CTC-326K19.6",30.97306243,7.408043106,2.055024233,3.576863527,{"v":5.38e-06,"d":"5.38E-06"},{"v":2.17e-05,"d":"2.17E-05"},"ENSG00000269179","H7BZU6,Uncharacterized protein","-","-","-","-","-","-"]
["AC011530.4",44.50649987,10.68053139,2.054928483,4.625592612,{"v":1.69E-9,"d":"1.69E-09"},{"v":1.48E-8,"d":"1.48E-08"},"ENSG00000268434","M0R0L4,Uncharacterized protein","-","-","IPR015943,WD40/YVTN repeat-like-containing domain superfamily","ENOG410IMGB,-;ENOG410Y8W3,-","-","-"]
["SETBP1",2.938705053,0.705221297,2.05424631,4.411727047,{"v":9.31e-09,"d":"9.31E-09"},{"v":6.91e-08,"d":"6.91E-08"},"ENSG00000152217","H2NW89,SET binding protein 1","XP_002828231.1,SET-binding protein isoform X1;XP_009250620.1,-","-","IPR017956,AT hook, DNA-binding motif","ENOG410ZICX,-;ENOG410ITIX,-","GO:0003677,molecular_function,DNA binding;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0005829,cellular_component,cytosol","-"]
["IL13RA1",10.91708353,2.623106262,2.053955796,4.935491772,1.09E-10,{"v":1.24e-09,"d":"1.24E-09"},"ENSG00000131724","Q96BB4,Interleukin 13 receptor, alpha 1","-","PF09240,Interleukin-6 receptor alpha chain, binding","IPR003532,Short hematopoietin receptor, family 2, conserved site;IPR015321,Type I cytokine receptor, cytokine-binding domain;IPR003961,Fibronectin type III;IPR036116,Fibronectin type III superfamily;IPR013783,Immunoglobulin-like fold","ENOG410IH4K,-;ENOG410YM7M,-","GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0004896,molecular_function,cytokine receptor activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ADAM9",63.58147388,15.30960404,2.053813337,8.096852469,{"v":1.52e-19,"d":"1.52E-19"},1.16E-17,"ENSG00000168615","H2QW21,ADAM metallopeptidase domain 9","-","PF00200,isintegrin;PF08516,ADAM cysteine-rich;PF01421,Reprolysin (M12B) family zinc metalloprotease;PF01562,Reprolysin family propeptide","IPR001590,Peptidase M12B, ADAM/reprolysin;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR001762,Disintegrin domain;IPR034027,Reprolysin domain, adamalysin-type;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR006586,ADAM, cysteine-rich;IPR018358,Disintegrin, conserved site;IPR036436,Disintegrin domain superfamily;IPR002870,Peptidase M12B, propeptide","ENOG410XX2M,-;KOG3607,Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family","GO:0008237,molecular_function,metallopeptidase activity;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0046872,molecular_function,metal ion binding;GO:0006508,biological_process,proteolysis","-"]
["HACD2",14.51120679,3.490341314,2.053710489,5.620549144,{"v":4.91e-13,"d":"4.91E-13"},{"v":9.54e-12,"d":"9.54E-12"},"ENSG00000206527","H2R830,Very-long-chain","XP_001168034.1,-","PF04387,Protein tyrosine phosphatase-like protein, PTPLA","IPR007482,Protein-tyrosine phosphatase-like, PTPLA","COG5198,Protein tyrosine phosphatase-like protein (contains Pro instead of catalytic Arg);KOG3187,Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg)","GO:0006631,biological_process,fatty acid metabolic process;GO:0006629,biological_process,lipid metabolic process;GO:0030148,biological_process,sphingolipid biosynthetic process;GO:0102343,molecular_function,3-hydroxy-arachidoyl-CoA dehydratase activity;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0019899,molecular_function,enzyme binding;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0042761,biological_process,very long-chain fatty acid biosynthetic process;GO:0030497,biological_process,fatty acid elongation;GO:0005783,cellular_component,endoplasmic reticulum;GO:0006633,biological_process,fatty acid biosynthetic process;GO:0102158,molecular_function,very-long-chain 3-hydroxyacyl-CoA dehydratase activity;GO:0016020,cellular_component,membrane;GO:0102344,molecular_function,3-hydroxy-behenoyl-CoA dehydratase activity;GO:0018812,molecular_function,3-hydroxyacyl-CoA dehydratase activity;GO:0102345,molecular_function,3-hydroxy-lignoceroyl-CoA dehydratase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016829,molecular_function,lyase activity","K10703,ko01212,Fatty acid metabolism;K10703,ko00062,Fatty acid elongation;K10703,ko01040,Biosynthesis of unsaturated fatty acids"]
["NR3C1",10.09697521,2.429253627,2.053647259,5.870129539,{"v":6.17e-14,"d":"6.17E-14"},1.47E-12,"ENSG00000113580","E5KQF6,Glucocorticoid receptor","XP_005268480.1,-;NP_001019265.1,glucocorticoid receptor isoform gamma;XP_005268479.1,-;XP_005268476.1,-;XP_005268477.1,-","PF00105,Zinc finger, C4 type (two domains);PF02155,lucocorticoid receptor;PF00104,Ligand-binding domain of nuclear hormone receptor","IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR001409,Glucocorticoid receptor;IPR013088,Zinc finger, NHR/GATA-type","KOG3575,FOG: Hormone receptors;ENOG410XRZC,-","GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0043402,biological_process,glucocorticoid mediated signaling pathway;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0042921,biological_process,glucocorticoid receptor signaling pathway;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005496,molecular_function,steroid binding;GO:0004883,molecular_function,glucocorticoid receptor activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0043401,biological_process,steroid hormone mediated signaling pathway;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["FOXN3",3.831043765,0.920653204,2.053301636,4.76575854,{"v":6.17e-10,"d":"6.17E-10"},{"v":5.99e-09,"d":"5.99E-09"},"ENSG00000053254","A0A024R6I1,Checkpoint suppressor 1, isoform CRA_a","NP_001078940.1,forkhead box protein N3 isoform 1","PF00250,orkhead domain","IPR018122,Fork head domain conserved site1;IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily","KOG2294,Transcription factor of the Forkhead/HNF3 family;COG5025,Transcription factor of the Forkhead/HNF3 family","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0097094,biological_process,craniofacial suture morphogenesis;GO:0005634,cellular_component,nucleus","-"]
["TBC1D9",2.203806453,0.526320008,2.053259755,3.087250262,1.08551E-4,0.000326036,"ENSG00000109436","K7BPQ8,TBC1 domain family, member 9","XP_001139147.3,-","PF00566,Rab-GTPase-TBC domain;PF02893,RAM domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR004182,GRAM domain;IPR000195,Rab-GTPase-TBC domain;IPR036017,TCB1D9/TCB1D9B, PH-GRAM domain 2;IPR011993,PH-like domain superfamily;IPR002048,EF-hand domain;IPR036014,TCB1D9/TCB1D9B, PH-GRAM domain 1;IPR011992,EF-hand domain pair","COG5210,GTPase-activating protein;KOG4347,GTPase-activating protein VRP","GO:0005509,molecular_function,calcium ion binding","-"]
["PCBP1",199.7379051,48.11971736,2.052960554,7.767926652,{"v":5.39e-19,"d":"5.39E-19"},{"v":3.62e-17,"d":"3.62E-17"},"ENSG00000169564","G3HXL1,Poly","XP_003508012.1,-","PF00013,KH domain","IPR004087,K Homology domain;IPR004088,K Homology domain, type 1;IPR036612,K Homology domain, type 1 superfamily","-","GO:0003697,molecular_function,single-stranded DNA binding;GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0039694,biological_process,viral RNA genome replication;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0098847,molecular_function,sequence-specific single stranded DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0003723,molecular_function,RNA binding;GO:0016607,cellular_component,nuclear speck;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0003729,molecular_function,mRNA binding;GO:0005654,cellular_component,nucleoplasm","K12889,ko03040,Spliceosome"]
["PATL1",21.31479565,5.131708934,2.05262826,5.848329704,{"v":7.98e-14,"d":"7.98E-14"},{"v":1.86e-12,"d":"1.86E-12"},"ENSG00000166889","G3QNX6,PAT1 homolog 1, processing body mRNA decay factor","XP_004051300.1,protein PAT1 homolog 1 isoform X3","PF09770,Topoisomerase II-associated protein PAT1","IPR019167,Topoisomerase II-associated protein PAT1","-","GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0033962,biological_process,cytoplasmic mRNA processing body assembly;GO:0000290,biological_process,deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0003723,molecular_function,RNA binding;GO:0008266,molecular_function,poly(U) RNA binding;GO:0000932,cellular_component,P-body;GO:0034046,molecular_function,poly(G) binding;GO:0030014,cellular_component,CCR4-NOT complex","K12617,ko03018,RNA degradation"]
["LIMK1",11.04385781,2.658526938,2.0524928,5.594585393,{"v":6.66e-13,"d":"6.66E-13"},1.26E-11,"ENSG00000106683","E9PC47,LIM domain kinase 1","-","PF07714,Protein tyrosine kinase;PF00595,PDZ domain (Also known as DHR or GLGF);PF00412,LIM domain","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR001781,Zinc finger, LIM-type;IPR000719,Protein kinase domain","ENOG410IEZ9,-;COG0515,Serine/threonine protein kinase","GO:0046872,molecular_function,metal ion binding;GO:0004672,molecular_function,protein kinase activity;GO:0016607,cellular_component,nuclear speck;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding","-"]
["RYBP",4.899670197,1.177704076,2.052453961,4.5732175,{"v":2.94e-09,"d":"2.94E-09"},{"v":2.43e-08,"d":"2.43E-08"},"ENSG00000163602","H2RE69,RING1 and YY1 binding protein","-","PF17219,Yaf2/RYBP C-terminal binding motif;PF00641,Zn-finger in Ran binding protein and others","-","-","-","-"]
["AGAP1",9.679360343,2.332040335,2.052157726,6.402596921,{"v":1.29e-15,"d":"1.29E-15"},{"v":4.57e-14,"d":"4.57E-14"},"ENSG00000157985","E7EUN2,Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1","-","PF12796,Ankyrin repeats (3 copies);PF01412,Putative GTPase activating protein for Arf;PF00071,Ras family","IPR037278,ARFGAP/RecO-like zinc finger;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR038508,ArfGAP domain superfamily;IPR001806,Small GTPase superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR001164,Arf GTPase activating protein;IPR002110,Ankyrin repeat","-","GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0046872,molecular_function,metal ion binding;GO:0005096,molecular_function,GTPase activator activity","-"]
["POM121",11.33870985,2.735532732,2.049961579,6.132821202,{"v":9.62e-15,"d":"9.62E-15"},{"v":2.77e-13,"d":"2.77E-13"},"ENSG00000196313","A0A075B7F8,Nuclear envelope pore membrane protein POM 121C","-","PF15229,POM121 family","IPR026090,Nuclear pore protein POM121;IPR026054,Nuclear pore complex protein","-","GO:0031965,cellular_component,nuclear membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["LEPR",0.605659122,0.144091225,2.048720298,2.331864209,1.887669E-3,0.004291487,"ENSG00000116678","H2RDQ7,Uncharacterized protein","XP_016775598.1,-;XP_001161937.1,leptin receptor isoform X1;XP_009458209.1,-;XP_016775608.1,-;XP_009458195.1,-","PF06328,Ig-like C2-type domain","IPR003529,Long hematopoietin receptor, Gp130 family 2, conserved site;IPR003531,Short hematopoietin receptor, family 1, conserved site;IPR010457,Immunoglobulin C2-set-like, ligand-binding;IPR036116,Fibronectin type III superfamily;IPR003961,Fibronectin type III;IPR013783,Immunoglobulin-like fold;IPR007110,Immunoglobulin-like domain;IPR015752,Leptin receptor","ENOG410IKH4,-;ENOG4110JZP,-","GO:0019953,biological_process,sexual reproduction;GO:0038021,molecular_function,leptin receptor activity;GO:0060259,biological_process,regulation of feeding behavior;GO:0033210,biological_process,leptin-mediated signaling pathway;GO:0010507,biological_process,negative regulation of autophagy;GO:0008203,biological_process,cholesterol metabolic process;GO:0042593,biological_process,glucose homeostasis;GO:0006909,biological_process,phagocytosis;GO:2000505,-,-;GO:0098868,biological_process,bone growth;GO:0046850,biological_process,regulation of bone remodeling;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0030217,biological_process,T cell differentiation;GO:0001525,biological_process,angiogenesis;GO:0016020,cellular_component,membrane;GO:0051346,biological_process,negative regulation of hydrolase activity;GO:0097009,biological_process,energy homeostasis;GO:0045721,biological_process,negative regulation of gluconeogenesis;GO:0043235,cellular_component,receptor complex;GO:0004896,molecular_function,cytokine receptor activity;GO:0044321,biological_process,response to leptin","K05062,ko04152,AMPK signaling pathway;K05062,ko04630,Jak-STAT signaling pathway;K05062,ko04080,Neuroactive ligand-receptor interaction;K05062,ko04920,Adipocytokine signaling pathway;K05062,ko04932,Non-alcoholic fatty liver disease (NAFLD);K05062,ko04060,Cytokine-cytokine receptor interaction"]
["RP11-186N15.3",2.743563432,0.652716026,2.048720298,2.331864209,1.887669E-3,0.004291487,"ENSG00000228302","G7N810,Uncharacterized protein","-","-","-","-","-","-"]
["ADPGK-AS1",2.194501024,0.522089619,2.048720298,2.331864209,1.887669E-3,0.004291487,"ENSG00000260898","F6UGS9,ADP dependent glucokinase","-","PF04587,ADP-specific Phosphofructokinase/Glucokinase conserved region","-","KOG4184,Predicted sugar kinase;ENOG410Z7J9,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CTB-55O6.12",2.161438862,0.514223862,2.048720298,2.331864209,1.887669E-3,0.004291487,"ENSG00000267169","H0VVN1,Adhesion G protein-coupled receptor L1","-","PF16489,PCR-Autoproteolysis INducing (GAIN) domain;PF00002,7 transmembrane receptor (Secretin family);PF02191,Olfactomedin-like domain;PF01825,PCR proteolysis site, GPS, motif;PF02793,Hormone receptor domain;PF02354,Latrophilin Cytoplasmic C-terminal region;PF02140,alactose binding lectin domain","IPR032471,GAIN domain, N-terminal;IPR036445,GPCR family 2, extracellular hormone receptor domain superfamily;IPR001879,GPCR, family 2, extracellular hormone receptor domain;IPR000832,GPCR, family 2, secretin-like;IPR017981,GPCR, family 2-like;IPR003334,GPCR, family 2, latrophilin, C-terminal;IPR000203,GPS motif;IPR003112,Olfactomedin-like domain;IPR017983,GPCR, family 2, secretin-like, conserved site;IPR003924,GPCR, family 2, latrophilin;IPR000922,D-galactoside/L-rhamnose binding SUEL lectin domain;IPR031234,Latrophilin-1","ENOG410XSD2,-;KOG4729,Galactoside-binding lectin;KOG3545,Olfactomedin and related extracellular matrix glycoproteins;KOG4193,G protein-coupled receptors","GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0030246,molecular_function,carbohydrate binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0007165,biological_process,signal transduction","-"]
["SULT2B1",2.44023537,0.580551816,2.048720298,2.331864209,1.887669E-3,0.004291487,"ENSG00000088002","H2R5X6,Sulfotransferase","XP_001171142.1,sulfotransferase family cytosolic 2B member 1","PF00685,Sulfotransferase domain","IPR000863,Sulfotransferase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG4111H56,-;KOG1584,Sulfotransferase","GO:0008146,molecular_function,sulfotransferase activity;GO:0008203,biological_process,cholesterol metabolic process;GO:0008202,biological_process,steroid metabolic process;GO:0045606,biological_process,positive regulation of epidermal cell differentiation;GO:0000103,biological_process,sulfate assimilation;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0016740,molecular_function,transferase activity;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0050294,molecular_function,steroid sulfotransferase activity;GO:0050427,biological_process,3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0003676,molecular_function,nucleic acid binding;GO:0005829,cellular_component,cytosol;GO:0015485,molecular_function,cholesterol binding;GO:1990239,molecular_function,steroid hormone binding","-"]
["TFAP2A-AS1",4.069943388,0.968272592,2.048720298,2.331864209,1.887669E-3,0.004291487,"ENSG00000229950","A0A024QZZ9,HCG1979341, isoform CRA_a","-","-","-","-","-","-"]
["AC004967.7",15.40569175,3.665139207,2.048720298,2.331864209,1.887669E-3,0.004291487,"ENSG00000243554","K7BL66,Chromosome 7 open reading frame 28A","-","PF08217,ungal domain of unknown function (DUF1712)","IPR013176,Protein of unknown function DUF1712, fungi","KOG2622,Putative myrosinase precursor;ENOG410XRE1,-","-","-"]
["MPZL2",22.83174551,5.515059038,2.04815729,6.096304093,1.15E-14,{"v":3.26e-13,"d":"3.26E-13"},"ENSG00000149573","G3RTC2,Myelin protein zero like 2","XP_004052261.1,-","PF07686,Immunoglobulin V-set domain","IPR013106,Immunoglobulin V-set domain;IPR000920,Myelin P0 protein-related;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR007110,Immunoglobulin-like domain;IPR003599,Immunoglobulin subtype;IPR029863,Myelin protein zero-like protein 2","-","GO:0098609,biological_process,cell-cell adhesion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["AMBRA1",6.901291854,1.665433906,2.04802508,5.082163672,{"v":3.86e-11,"d":"3.86E-11"},{"v":4.84e-10,"d":"4.84E-10"},"ENSG00000110497","H2Q3H6,Uncharacterized protein","XP_009458595.2,activating molecule in BECN1-regulated autophagy protein 1 isoform X2","-","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR019775,WD40 repeat, conserved site;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","ENOG410ZUDQ,-;KOG0266,WD40 repeat-containing protein","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0006914,biological_process,autophagy","-"]
["SESN3",5.390185838,1.30160453,2.047311037,5.185493244,{"v":1.87e-11,"d":"1.87E-11"},2.54E-10,"ENSG00000149212","G3QQF9,Sestrin 3","XP_004052041.1,sestrin-3 isoform X1","PF04636,PA26 p53-induced protein (sestrin)","IPR029032,AhpD-like;IPR006730,Sestrin","-","GO:0042149,biological_process,cellular response to glucose starvation;GO:0031932,cellular_component,TORC2 complex;GO:0042593,biological_process,glucose homeostasis;GO:0051896,biological_process,regulation of protein kinase B signaling;GO:0005737,cellular_component,cytoplasm;GO:0032868,biological_process,response to insulin;GO:1901031,biological_process,regulation of response to reactive oxygen species;GO:0046626,biological_process,regulation of insulin receptor signaling pathway;GO:0005634,cellular_component,nucleus;GO:0071230,biological_process,cellular response to amino acid stimulus;GO:0061700,cellular_component,GATOR2 complex;GO:1904262,biological_process,negative regulation of TORC1 signaling;GO:0038203,biological_process,TORC2 signaling;GO:0034198,biological_process,cellular response to amino acid starvation","K10141,ko04211,Longevity regulating pathway;K10141,ko04115,p53 signaling pathway"]
["ZNF526",7.950550404,1.917955075,2.046898078,4.462345108,{"v":5.1e-09,"d":"5.10E-09"},{"v":3.99E-8,"d":"3.99E-08"},"ENSG00000167625","H9ZYJ3,Zinc finger protein 526","NP_597701.1,zinc finger protein 526;NP_001300962.1,-","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["POGZ",8.044794642,1.945820692,2.045795299,5.710107318,{"v":3.1e-13,"d":"3.10E-13"},6.39E-12,"ENSG00000143442","H2PZZ1,Pogo transposable element with ZNF domain","XP_003308425.1,-","PF03184,superfamily endonuclease;PF03221,Tc5 transposase DNA-binding domain","IPR013087,Zinc finger C2H2-type;IPR006600,HTH CenpB-type DNA-binding domain;IPR009057,Homeobox-like domain superfamily;IPR004875,DDE superfamily endonuclease domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger;KOG3105,DNA-binding centromere protein B (CENP-B)","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["MLH1",6.924800386,1.669859007,2.045679985,4.010197309,{"v":2.7e-07,"d":"2.70E-07"},{"v":1.43e-06,"d":"1.43E-06"},"ENSG00000076242","B2R6K0,cDNA, FLJ92988, highly similar to Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2","-","PF13589,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase;PF16413,NA mismatch repair protein Mlh1 C-terminus;PF01119,NA mismatch repair protein, C-terminal domain","IPR011186,DNA mismatch repair protein Mlh1;IPR014762,DNA mismatch repair, conserved site;IPR013507,DNA mismatch repair protein, C-terminal;IPR014721,Ribosomal protein S5 domain 2-type fold, subgroup;IPR020568,Ribosomal protein S5 domain 2-type fold;IPR002099,DNA mismatch repair protein family;IPR032189,DNA mismatch repair protein Mlh1, C-terminal;IPR003594,Histidine kinase/HSP90-like ATPase;IPR036890,Histidine kinase/HSP90-like ATPase superfamily","COG0323,DNA mismatch repair enzyme (predicted ATPase);KOG1979,DNA mismatch repair protein - MLH1 family","GO:0006298,biological_process,mismatch repair;GO:0005524,molecular_function,ATP binding;GO:0030983,molecular_function,mismatched DNA binding;GO:0032300,cellular_component,mismatch repair complex","-"]
["RIMS2",1.795638717,0.433003598,2.045679985,4.010197309,{"v":2.7e-07,"d":"2.70E-07"},{"v":1.43e-06,"d":"1.43E-06"},"ENSG00000176406","D6RA03,Regulating synaptic membrane exocytosis protein 2","-","PF00168,C2 domain","IPR000008,C2 domain;IPR030631,Regulating synaptic membrane exocytosis protein 2;IPR001478,PDZ domain;IPR036034,PDZ superfamily;IPR035892,C2 domain superfamily","KOG2060,Rab3 effector RIM1 and related proteins, contain PDZ and C2 domains;ENOG410ZNB1,-;KOG3799,Rab3 effector RIM1 and related proteins, contain Rab3a binding domain","GO:0048791,biological_process,calcium ion-regulated exocytosis of neurotransmitter;GO:0048786,cellular_component,presynaptic active zone;GO:0017157,biological_process,regulation of exocytosis","-"]
["MT-TN",575.7595303,139.1447507,2.045180387,4.759360343,{"v":7.64e-10,"d":"7.64E-10"},{"v":7.2E-9,"d":"7.20E-09"},"-","-","-","-","-","-","-","-"]
["PITRM1-AS1",2.499580477,0.599841547,2.044750888,2.927024044,1.42624E-4,0.000418537,"ENSG00000237399","G2HGK9,Metalloprotease 1","NP_001267394.1,presequence protease, mitochondrial","PF05193,Peptidase M16 inactive domain;PF00675,Insulinase (Peptidase family M16);PF08367,Peptidase M16C associated","IPR011765,Peptidase M16, N-terminal;IPR013578,Peptidase M16C associated;IPR011249,Metalloenzyme, LuxS/M16 peptidase-like;IPR007863,Peptidase M16, C-terminal","KOG2019,Metalloendoprotease HMP1 (insulinase superfamily);COG1026,Predicted Zn-dependent peptidases, insulinase-like","GO:0006508,biological_process,proteolysis;GO:0003824,molecular_function,catalytic activity;GO:0008233,molecular_function,peptidase activity;GO:0046872,molecular_function,metal ion binding;GO:0008237,molecular_function,metallopeptidase activity","-"]
["FAM86C1",3.675358911,0.882001198,2.044750888,2.927024044,1.42624E-4,0.000418537,"ENSG00000158483","H2RAB5,Family with sequence similarity 86 member C1","-","PF14904,amily of unknown function","IPR029426,FAM86","KOG2497,Predicted methyltransferase;ENOG410ZQK4,-","-","-"]
["ZC3H12C",1.123898208,0.269709596,2.044750888,2.927024044,1.42624E-4,0.000418537,"ENSG00000149289","H2Q4Q5,Uncharacterized protein","-","PF11977,Zc3h12a-like Ribonuclease NYN domain","-","-","-","-"]
["NPIPP1",7.601368603,1.824152791,2.044750888,2.927024044,1.42624E-4,0.000418537,"ENSG00000188599","A0A0B4J1W7,Nuclear pore complex-interacting protein family member A5","-","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);ENOG410J0WZ,-","GO:0005654,cellular_component,nucleoplasm","-"]
["CTD-3032J10.2",22.0670034,5.29557083,2.044750888,2.927024044,1.42624E-4,0.000418537,"ENSG00000268056","A0A0D9R036,Myosin IXB","-","PF00788,Ras association (RalGDS/AF-6) domain;PF00620,RhoGAP domain;PF00063,Myosin head (motor domain);PF00612,IQ calmodulin-binding motif","IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR000159,Ras-associating (RA) domain;IPR000048,IQ motif, EF-hand binding site;IPR000198,Rho GTPase-activating protein domain;IPR028557,Unconventional myosin-IXb;IPR036961,Kinesin motor domain superfamily;IPR036023,Class IX myosin, motor domain;IPR008936,Rho GTPase activation protein;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR029071,Ubiquitin-like domain superfamily","-","GO:0005884,cellular_component,actin filament;GO:0035385,biological_process,Roundabout signaling pathway;GO:0008017,molecular_function,microtubule binding;GO:0003774,molecular_function,motor activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0016887,molecular_function,ATPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0000146,molecular_function,microfilament motor activity;GO:0005524,molecular_function,ATP binding;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0000166,molecular_function,nucleotide binding;GO:0005516,molecular_function,calmodulin binding;GO:0005938,cellular_component,cell cortex;GO:0030048,biological_process,actin filament-based movement;GO:0005829,cellular_component,cytosol;GO:0003779,molecular_function,actin binding;GO:0007018,biological_process,microtubule-based movement;GO:0016459,cellular_component,myosin complex;GO:0017048,molecular_function,Rho GTPase binding;GO:0003777,molecular_function,microtubule motor activity;GO:0007165,biological_process,signal transduction;GO:0043531,molecular_function,ADP binding;GO:0048495,molecular_function,Roundabout binding;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0046872,molecular_function,metal ion binding;GO:0035023,biological_process,regulation of Rho protein signal transduction","-"]
["ARMC9",1.130645553,0.271328802,2.044750888,2.927024044,1.42624E-4,0.000418537,"ENSG00000135931","A0A087X1I8,LisH domain-containing protein ARMC9","-","-","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR006594,LIS1 homology motif","-","-","-"]
["AP5S1",1.989647848,0.477469501,2.044750888,2.927024044,1.42624E-4,0.000418537,"ENSG00000125843","H2QJW4,Chromosome 20 open reading frame 29","XP_001163166.1,-;XP_514488.2,-;XP_016792870.1,-;XP_016792871.1,-","PF15001,AP-5 complex subunit sigma-1","IPR029392,AP-5 complex subunit sigma-1","ENOG410IYQV,-;ENOG4111NAX,-","GO:0005770,cellular_component,late endosome;GO:0005764,cellular_component,lysosome;GO:0016197,biological_process,endosomal transport;GO:0030119,cellular_component,AP-type membrane coat adaptor complex;GO:0005829,cellular_component,cytosol;GO:0000724,biological_process,double-strand break repair via homologous recombination;GO:0005654,cellular_component,nucleoplasm","-"]
["ZFAND5",9.023014169,2.183493821,2.044530183,5.34132503,{"v":5.41e-12,"d":"5.41E-12"},{"v":8.2e-11,"d":"8.20E-11"},"ENSG00000107372","H0V4L7,Uncharacterized protein","XP_013010522.1,-;XP_005004802.1,-","PF01754,A20-like zinc finger;PF01428,AN1-like Zinc finger","IPR002653,Zinc finger, A20-type;IPR000058,Zinc finger, AN1-type;IPR035896,AN1-like Zinc finger","KOG3173,Predicted Zn-finger protein;ENOG4111UWC,-","GO:0003677,molecular_function,DNA binding;GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding","-"]
["CES2",9.377520242,2.269052493,2.044017047,5.005312314,{"v":9.22e-11,"d":"9.22E-11"},{"v":1.06e-09,"d":"1.06E-09"},"ENSG00000172831","A0A024R6X1,Carboxylic ester hydrolase","NP_003860.2,cocaine esterase isoform 1","PF07859,alpha/beta hydrolase fold;PF00135,Carboxylesterase family","IPR019819,Carboxylesterase type B, conserved site;IPR019826,Carboxylesterase type B, active site;IPR029058,Alpha/Beta hydrolase fold;IPR002018,Carboxylesterase, type B","COG2272,Carboxylesterase type B;KOG1516,Carboxylesterase and related proteins","GO:0016787,molecular_function,hydrolase activity","-"]
["SLC25A12",9.693188364,2.34543383,2.044017047,5.005312314,{"v":9.22e-11,"d":"9.22E-11"},{"v":1.06e-09,"d":"1.06E-09"},"ENSG00000115840","B3KMV8,cDNA FLJ12766 fis, clone NT2RP2001520, highly similar to Calcium-binding mitochondrial carrier protein Aralar1","-","PF00153,Mitochondrial carrier protein","IPR023395,Mitochondrial carrier domain superfamily;IPR018247,EF-Hand 1, calcium-binding site;IPR002067,Mitochondrial carrier protein;IPR002048,EF-hand domain;IPR018108,Mitochondrial substrate/solute carrier;IPR011992,EF-hand domain pair","ENOG410XNRM,-;KOG0751,Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains)","GO:0055085,biological_process,transmembrane transport;GO:0005509,molecular_function,calcium ion binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TACC2",4.738113703,1.147621915,2.043927046,5.820104238,{"v":1.35e-13,"d":"1.35E-13"},2.99E-12,"ENSG00000138162","H2Q2P6,Uncharacterized protein","XP_009457662.2,transforming acidic coiled-coil-containing protein 2 isoform X17","PF05010,Transforming acidic coiled-coil-containing protein (TACC)","IPR007707,Transforming acidic coiled-coil-containing protein, C-terminal","ENOG410YMFS,-;ENOG410IIVK,-","GO:0005737,cellular_component,cytoplasm;GO:0008283,biological_process,cell proliferation;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0021987,biological_process,cerebral cortex development;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["NECTIN4",22.783155,5.520315037,2.043200894,5.660917432,{"v":3.62e-13,"d":"3.62E-13"},{"v":7.32e-12,"d":"7.32E-12"},"ENSG00000143217","K4PZ75,Ig superfamily receptor LNIR","NP_112178.2,nectin-4 precursor","PF13927,Immunoglobulin domain;PF08205,CD80-like C2-set immunoglobulin domain;PF07686,Immunoglobulin V-set domain","IPR007110,Immunoglobulin-like domain;IPR013162,CD80-like, immunoglobulin C2-set;IPR033320,Nectin-4;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain","ENOG410IFPI,-;ENOG4111HYP,-","GO:0007155,biological_process,cell adhesion;GO:0046718,biological_process,viral entry into host cell;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K06593,ko04520,Adherens junction"]
["TBC1D8",13.90106655,3.369010546,2.042948699,5.730841609,{"v":2.34e-13,"d":"2.34E-13"},{"v":4.96e-12,"d":"4.96E-12"},"ENSG00000204634","J3KQ40,TBC1 domain family member 8","NP_001317277.1,TBC1 domain family member 8 isoform 1","PF00566,Rab-GTPase-TBC domain;PF02893,RAM domain","IPR036009,TBC1D8, PH-GRAM domain 1;IPR035969,Rab-GTPase-TBC domain superfamily;IPR004182,GRAM domain;IPR000195,Rab-GTPase-TBC domain;IPR036016,TBC1D8, PH-GRAM domain 2;IPR011993,PH-like domain superfamily;IPR011992,EF-hand domain pair","COG5210,GTPase-activating protein;KOG4347,GTPase-activating protein VRP","-","-"]
["S1PR5",5.331428779,1.284496755,2.042922459,3.344380311,{"v":1.57e-05,"d":"1.57E-05"},{"v":5.72e-05,"d":"5.72E-05"},"ENSG00000180739","K7A2J1,Sphingosine-1-phosphate receptor 5","XP_016790483.1,-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR004061,Sphingosine 1-phosphate receptor;IPR017452,GPCR, rhodopsin-like, 7TM;IPR005386,EDG-8 sphingosine 1-phosphate receptor;IPR000276,G protein-coupled receptor, rhodopsin-like","-","GO:0003376,biological_process,sphingosine-1-phosphate signaling pathway;GO:0016020,cellular_component,membrane;GO:0004871,molecular_function,signal transducer activity;GO:0016021,cellular_component,integral component of membrane;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0038036,molecular_function,sphingosine-1-phosphate receptor activity;GO:0007165,biological_process,signal transduction","-"]
["SYNJ1",1.853778086,0.446629231,2.042922459,3.344380311,{"v":1.57e-05,"d":"1.57E-05"},{"v":5.72e-05,"d":"5.72E-05"},"ENSG00000159082","J3KQV8,Synaptojanin-1","NP_003886.3,synaptojanin-1 isoform a","PF03372,ndonuclease/Exonuclease/phosphatase family;PF02383,SacI homology domain;PF08952,omain of unknown function (DUF1866)","IPR034971,Synaptojanin-1, RNA recognition motif;IPR015047,Domain of unknown function DUF1866;IPR034972,Synaptojanin-1;IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR002013,SAC domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR000300,Inositol polyphosphate-related phosphatase;IPR035979,RNA-binding domain superfamily;IPR005135,Endonuclease/exonuclease/phosphatase","COG5329,Phosphoinositide polyphosphatase (Sac family);COG5411,Phosphatidylinositol 5-phosphate phosphatase;KOG0566,Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family","GO:0030132,cellular_component,clathrin coat of coated pit;GO:0046856,biological_process,phosphatidylinositol dephosphorylation;GO:0048260,biological_process,positive regulation of receptor-mediated endocytosis;GO:0042578,molecular_function,phosphoric ester hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0048488,biological_process,synaptic vesicle endocytosis;GO:0034097,biological_process,response to cytokine;GO:0032526,biological_process,response to retinoic acid;GO:0003723,molecular_function,RNA binding;GO:0016787,molecular_function,hydrolase activity;GO:0017124,molecular_function,SH3 domain binding;GO:0008022,molecular_function,protein C-terminus binding;GO:0034595,molecular_function,phosphatidylinositol phosphate 5-phosphatase activity;GO:0007420,biological_process,brain development;GO:0005874,cellular_component,microtubule;GO:0014015,biological_process,positive regulation of gliogenesis;GO:0097060,cellular_component,synaptic membrane;GO:0043005,cellular_component,neuron projection","K20279,ko04070,Phosphatidylinositol signaling system;K20279,ko00562,Inositol phosphate metabolism"]
["NME4",51.89183556,12.58870457,2.042564028,6.89957019,{"v":5.37e-17,"d":"5.37E-17"},{"v":2.51e-15,"d":"2.51E-15"},"ENSG00000103202","F2Z2X0,Nucleoside diphosphate kinase","-","PF00334,Nucleoside diphosphate kinase","IPR034907,Nucleoside diphosphate kinase-like domain;IPR036850,Nucleoside diphosphate kinase-like domain superfamily;IPR001564,Nucleoside diphosphate kinase;IPR023005,Nucleoside diphosphate kinase, active site","KOG0888,Nucleoside diphosphate kinase;COG0105,Nucleoside diphosphate kinase","GO:0006183,biological_process,GTP biosynthetic process;GO:0016301,molecular_function,kinase activity;GO:0006165,biological_process,nucleoside diphosphate phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0006241,biological_process,CTP biosynthetic process;GO:0016310,biological_process,phosphorylation;GO:0006228,biological_process,UTP biosynthetic process;GO:0004550,molecular_function,nucleoside diphosphate kinase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["TFAP2C",30.58138976,7.414680288,2.042510857,5.861261046,{"v":8.03e-14,"d":"8.03E-14"},{"v":1.87e-12,"d":"1.87E-12"},"ENSG00000087510","G3QDT6,Transcription factor AP-2 gamma","XP_004062458.1,-","PF03299,Transcription factor AP-2","IPR004979,Transcription factor AP-2;IPR013854,Transcription factor AP-2, C-terminal;IPR008123,Transcription factor AP-2 gamma","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0040029,biological_process,regulation of gene expression, epigenetic;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0008584,biological_process,male gonad development;GO:0005739,cellular_component,mitochondrion;GO:0001047,molecular_function,core promoter binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["MET",9.985538145,2.420585189,2.042279108,5.481915348,1.79E-12,{"v":3.06e-11,"d":"3.06E-11"},"ENSG00000105976","A0A024R728,Met proto-oncogene","NP_001120972.1,hepatocyte growth factor receptor isoform a preproprotein","PF01437,Plexin repeat;PF01403,Sema domain;PF01833,IPT/TIG domain;PF07714,Protein tyrosine kinase","IPR013783,Immunoglobulin-like fold;IPR001627,Sema domain;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR036352,Sema domain superfamily;IPR016201,PSI domain;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR002165,Plexin repeat;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR014756,Immunoglobulin E-set;IPR002909,IPT domain;IPR016244,Tyrosine-protein kinase, HGF/MSP receptor;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG3610,Plexins (functional semaphorin receptors);KOG1095,Protein tyrosine kinase","GO:0016301,molecular_function,kinase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0004714,molecular_function,transmembrane receptor protein tyrosine kinase activity;GO:0016310,biological_process,phosphorylation;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","-"]
["NUP54",10.99027753,2.661962995,2.042192125,4.844098074,{"v":3.47e-10,"d":"3.47E-10"},{"v":3.55e-09,"d":"3.55E-09"},"ENSG00000138750","Q53FD7,Nucleoporin 54kDa variant","-","PF13874,Nucleoporin complex subunit 54","IPR025712,Nucleoporin Nup54, alpha-helical domain;IPR024864,Nucleoporin Nup54/Nup57/Nup44","KOG3091,Nuclear pore complex, p54 component (sc Nup57);ENOG410XPU5,-","GO:0005643,cellular_component,nuclear pore","-"]
["BTBD11",2.39737653,0.57891068,2.041870757,3.666411367,{"v":3.14E-6,"d":"3.14E-06"},{"v":1.33E-5,"d":"1.33E-05"},"ENSG00000151136","G3QUY8,BTB domain containing 11","XP_004053870.1,ankyrin repeat and BTB/POZ domain-containing protein BTBD11 isoform X1","PF12796,Ankyrin repeats (3 copies);PF00651,BTB/POZ domain","IPR002110,Ankyrin repeat;IPR011333,SKP1/BTB/POZ domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR000210,BTB/POZ domain;IPR009072,Histone-fold","-","GO:0060395,biological_process,SMAD protein signal transduction;GO:0046982,molecular_function,protein heterodimerization activity","-"]
["ZFAT",2.134473216,0.515425644,2.041870757,3.666411367,{"v":3.14E-6,"d":"3.14E-06"},{"v":1.33E-5,"d":"1.33E-05"},"ENSG00000066827","K7CRU7,Zinc finger and AT hook domain containing","-","PF00096,Zinc finger, C2H2 type;PF13909,C2H2-type zinc-finger domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["PEAK1",3.574077608,0.867121257,2.04147364,5.774590204,1.54E-13,3.37E-12,"ENSG00000173517","G3QEM2,Pseudopodium enriched atypical kinase 1","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR008266,Tyrosine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["TP53I11",3.135961075,0.758376932,2.041187553,3.928830836,{"v":5.67e-07,"d":"5.67E-07"},{"v":2.83E-6,"d":"2.83E-06"},"ENSG00000175274","E9PPM1,Tumor protein p53-inducible protein 11","-","PF14936,Tumour protein p53-inducible protein 11","IPR028266,Tumor protein p53-inducible protein 11","ENOG410IV8J,-;ENOG4111H6J,-","-","-"]
["PPP1R10",19.67071577,4.775152795,2.04092192,6.017713022,{"v":2.18e-14,"d":"2.18E-14"},{"v":5.72e-13,"d":"5.72E-13"},"ENSG00000204569","Q2L6I0,FB19 protein","XP_006715193.1,-;NP_002705.2,serine/threonine-protein phosphatase 1 regulatory subunit 10;XP_016866484.1,-;XP_011513024.1,-","PF08711,TFIIS helical bundle-like domain;PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR003617,Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type;IPR036855,Zinc finger, CCCH-type superfamily;IPR035441,TFIIS/LEDGF domain superfamily;IPR000571,Zinc finger, CCCH-type;IPR017923,Transcription factor IIS, N-terminal","ENOG410XP4M,-;ENOG410IGTC,-","GO:0072357,cellular_component,PTW/PP1 phosphatase complex;GO:0000785,cellular_component,chromatin;GO:0046872,molecular_function,metal ion binding;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["TXNL1",6.80979705,1.653108193,2.040419585,5.609986474,{"v":6.6e-13,"d":"6.60E-13"},1.25E-11,"ENSG00000091164","F6S6V9,Thioredoxin like 1","XP_002757317.1,-","PF00085,Thioredoxin;PF06201,PITH domain","IPR036249,Thioredoxin-like superfamily;IPR037047,PITH domain superfamily;IPR017937,Thioredoxin, conserved site;IPR013766,Thioredoxin domain;IPR010400,PITH domain;IPR008979,Galactose-binding-like domain superfamily","ENOG410YQ2G,-;KOG0908,Thioredoxin-like protein","GO:0005737,cellular_component,cytoplasm;GO:0005829,cellular_component,cytosol;GO:0055114,biological_process,oxidation-reduction process;GO:0045454,biological_process,cell redox homeostasis;GO:0015036,molecular_function,disulfide oxidoreductase activity","-"]
["ANKRD27",6.529776115,1.585131879,2.039415774,5.038991935,{"v":7.19e-11,"d":"7.19E-11"},{"v":8.45e-10,"d":"8.45E-10"},"ENSG00000105186","H2QFZ0,Ankyrin repeat domain 27","XP_001151730.1,ankyrin repeat domain-containing protein 27 isoform X1","PF12796,Ankyrin repeats (3 copies);PF02204,Vacuolar sorting protein 9 (VPS9) domain","IPR037191,VPS9 domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR003123,VPS9 domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","ENOG410IQ81,-;COG0666,FOG: Ankyrin repeat","GO:0035646,biological_process,endosome to melanosome transport;GO:0000149,molecular_function,SNARE binding;GO:0005770,cellular_component,late endosome;GO:0017137,molecular_function,Rab GTPase binding;GO:0005764,cellular_component,lysosome;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0030133,cellular_component,transport vesicle;GO:0042470,cellular_component,melanosome;GO:0050775,biological_process,positive regulation of dendrite morphogenesis;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0045022,biological_process,early endosome to late endosome transport;GO:0005886,cellular_component,plasma membrane;GO:0005769,cellular_component,early endosome;GO:0035544,biological_process,negative regulation of SNARE complex assembly;GO:0097422,cellular_component,tubular endosome;GO:0005829,cellular_component,cytosol;GO:0048812,biological_process,neuron projection morphogenesis;GO:0043005,cellular_component,neuron projection;GO:1990126,biological_process,retrograde transport, endosome to plasma membrane","-"]
["ARHGAP27",5.170099077,1.257101266,2.037228168,5.109101191,{"v":3.06e-11,"d":"3.06E-11"},{"v":3.94e-10,"d":"3.94E-10"},"ENSG00000159314","A0A0G2JNY3,Rho GTPase-activating protein 27","-","PF00397,WW domain;PF00620,RhoGAP domain;PF00169,PH domain","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR001202,WW domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR008936,Rho GTPase activation protein;IPR001452,SH3 domain;IPR036020,WW domain superfamily;IPR000198,Rho GTPase-activating protein domain","-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0007165,biological_process,signal transduction;GO:0005096,molecular_function,GTPase activator activity","-"]
["WSCD1",4.157252048,1.0101934,2.036910883,4.611431791,{"v":2.66e-09,"d":"2.66E-09"},{"v":2.22E-8,"d":"2.22E-08"},"ENSG00000179314","G3QNF2,WSC domain containing 1","XP_018869172.1,-;XP_004058459.1,WSC domain-containing protein 1;XP_018869171.1,-","PF01822,WSC domain;PF00685,Sulfotransferase domain","IPR002889,Carbohydrate-binding WSC;IPR000863,Sulfotransferase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0008146,molecular_function,sulfotransferase activity","-"]
["DCBLD1",4.944909903,1.201288477,2.036784149,4.454419213,{"v":6.5e-09,"d":"6.50E-09"},{"v":5e-08,"d":"5.00E-08"},"ENSG00000164465","H2PK65,Discoidin, CUB and LCCL domain containing 1","XP_002817333.1,discoidin, CUB and LCCL domain-containing protein 1 isoform X1","PF00431,CUB domain;PF00754,5/8 type C domain;PF03815,LCCL domain","IPR000421,Coagulation factor 5/8 C-terminal domain;IPR035914,Spermadhesin, CUB domain superfamily;IPR004043,LCCL domain;IPR000859,CUB domain;IPR036609,LCCL domain superfamily;IPR008979,Galactose-binding-like domain superfamily","ENOG410II5Z,-;ENOG4110JCT,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CDRT4",9.147155057,2.221447085,2.036622999,4.278048857,{"v":4.21E-8,"d":"4.21E-08"},{"v":2.7e-07,"d":"2.70E-07"},"ENSG00000239704","D3DTT2,CMT1A duplicated region transcript 4 protein","NP_001191406.1,CMT1A duplicated region transcript 4 protein","PF15213,CMT1A duplicated region transcript 4 protein","IPR029185,CMT1A duplicated region transcript 4 protein","ENOG41117EI,-;ENOG410IZX3,-","GO:0005515,molecular_function,protein binding","-"]
["CTB-193M12.5",24.49985626,5.944008074,2.036120472,3.842534895,{"v":6.24e-07,"d":"6.24E-07"},{"v":3.08e-06,"d":"3.08E-06"},"-","-","-","-","-","-","-","-"]
["GTF2B",30.84313797,7.510487955,2.035725875,5.449349917,{"v":2.93e-12,"d":"2.93E-12"},{"v":4.76e-11,"d":"4.76E-11"},"ENSG00000137947","F2Z5J6,General transcription factor IIB","XP_001929441.3,-","PF00382,Transcription factor TFIIB repeat;PF08271,TFIIB zinc-binding","IPR013150,Transcription factor TFIIB, cyclin-like domain;IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR023486,Transcription factor TFIIB, conserved site;IPR013137,Zinc finger, TFIIB-type;IPR000812,Transcription factor TFIIB","COG1405,Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB;KOG1597,Transcription initiation factor TFIIB","GO:0050434,biological_process,positive regulation of viral transcription;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0017025,molecular_function,TBP-class protein binding;GO:0005634,cellular_component,nucleus;GO:1904798,biological_process,positive regulation of core promoter binding;GO:0051123,biological_process,RNA polymerase II transcriptional preinitiation complex assembly;GO:0006473,biological_process,protein acetylation;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0097550,cellular_component,transcriptional preinitiation complex;GO:0005669,cellular_component,transcription factor TFIID complex;GO:0003677,molecular_function,DNA binding;GO:0005694,cellular_component,chromosome;GO:0000993,molecular_function,RNA polymerase II core binding;GO:0060261,biological_process,positive regulation of transcription initiation from RNA polymerase II promoter;GO:0043923,biological_process,positive regulation by host of viral transcription;GO:0046966,molecular_function,thyroid hormone receptor binding;GO:0000979,molecular_function,RNA polymerase II core promoter sequence-specific DNA binding;GO:0006367,biological_process,transcription initiation from RNA polymerase II promoter;GO:0016604,cellular_component,nuclear body;GO:0016407,molecular_function,acetyltransferase activity;GO:0046872,molecular_function,metal ion binding;GO:0070897,biological_process,DNA-templated transcriptional preinitiation complex assembly","K03124,ko05169,Epstein-Barr virus infection;K03124,ko05203,Viral carcinogenesis;K03124,ko03022,Basal transcription factors"]
["SPATA5",2.130720353,0.516505976,2.035696515,3.561985527,{"v":7.35e-06,"d":"7.35E-06"},{"v":2.88e-05,"d":"2.88E-05"},"ENSG00000145375","H2QQ49,Spermatogenesis associated 5","XP_517427.2,spermatogenesis-associated protein 5 isoform X1","PF00004,ATPase family associated with various cellular activities (AAA)","IPR009010,Aspartate decarboxylase-like domain superfamily;IPR003959,ATPase, AAA-type, core;IPR003593,AAA+ ATPase domain;IPR003960,ATPase, AAA-type, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0730,AAA+-type ATPase;COG0464,ATPases of the AAA+ class","GO:0005737,cellular_component,cytoplasm;GO:0007420,biological_process,brain development;GO:0005524,molecular_function,ATP binding","-"]
["GAB1",1.736540246,0.420953136,2.035696515,3.561985527,{"v":7.35e-06,"d":"7.35E-06"},{"v":2.88e-05,"d":"2.88E-05"},"ENSG00000109458","G3QCS4,GRB2 associated binding protein 1","XP_004040476.1,GRB2-associated-binding protein 1 isoform X1","PF00169,PH domain","IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","-","GO:0090668,biological_process,endothelial cell chemotaxis to vascular endothelial growth factor;GO:0001525,biological_process,angiogenesis;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0038084,biological_process,vascular endothelial growth factor signaling pathway;GO:0045766,biological_process,positive regulation of angiogenesis","-"]
["CTD-3222D19.2",25.1613399,6.126936254,2.035585745,5.363863245,5.27E-12,8.01E-11,"ENSG00000141979","B8ZZF3,Uncharacterized protein","-","PF08711,TFIIS helical bundle-like domain;PF15694,Mediator complex subunit 26 middle domain","IPR031417,Mediator complex subunit 26, middle domain;IPR035441,TFIIS/LEDGF domain superfamily;IPR017923,Transcription factor IIS, N-terminal;IPR003617,Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type","COG1594,DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS;KOG1105,Transcription elongation factor TFIIS/Cofactor of enhancer-binding protein Sp1","GO:0005634,cellular_component,nucleus","-"]
["UBE2J1",12.23279536,2.978758592,2.03503622,5.071901355,{"v":4.66e-11,"d":"4.66E-11"},{"v":5.73e-10,"d":"5.73E-10"},"ENSG00000198833","G3RC25,Ubiquitin conjugating enzyme E2 J1","XP_004044450.1,-","PF00179,Ubiquitin-conjugating enzyme","IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR000608,Ubiquitin-conjugating enzyme E2","-","GO:0007286,biological_process,spermatid development;GO:1904153,biological_process,negative regulation of retrograde protein transport, ER to cytosol;GO:0061631,molecular_function,ubiquitin conjugating enzyme activity;GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0016567,biological_process,protein ubiquitination;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0042534,biological_process,regulation of tumor necrosis factor biosynthetic process;GO:0018279,biological_process,protein N-linked glycosylation via asparagine;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K10578,ko04120,Ubiquitin mediated proteolysis;K10578,ko04141,Protein processing in endoplasmic reticulum;K10578,ko05012,Parkinson's disease"]
["KIAA1211L",2.876775405,0.696415399,2.03502057,3.212070366,{"v":4.05e-05,"d":"4.05E-05"},0.00013434,"ENSG00000196872","H2R316,Uncharacterized protein","XP_515643.2,uncharacterized protein KIAA1211-like homolog isoform X6","PF15262,omain of unknown function (DUF4592)","IPR026713,Uncharacterised protein KIAA1211-like;IPR028030,Domain of unknown function DUF4592","ENOG410YAR8,-;ENOG410IIB6,-","-","-"]
["AL034550.1",6.625172923,1.603834778,2.03502057,3.212070366,{"v":4.05e-05,"d":"4.05E-05"},0.00013434,"ENSG00000283233","A0A087X0N3,Nucleolar protein 4-like","NP_001243727.1,nucleolar protein 4-like isoform 1","-","IPR026746,Nucleolar protein 4-like","ENOG410IHZD,-;ENOG410YIBB,-","GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm","-"]
["NXT2",4.417502703,1.069397667,2.03502057,3.212070366,{"v":4.05e-05,"d":"4.05E-05"},0.00013434,"ENSG00000101888","G3RCM5,Nuclear transport factor 2 like export factor 2","XP_004064745.1,NTF2-related export protein 2","PF02136,Nuclear transport factor 2 (NTF2) domain","IPR032710,NTF2-like domain superfamily;IPR018222,Nuclear transport factor 2, eukaryote;IPR002075,Nuclear transport factor 2","-","GO:0005737,cellular_component,cytoplasm;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0005654,cellular_component,nucleoplasm","K14285,ko03013,RNA transport;K14285,ko03015,mRNA surveillance pathway;K14285,ko03008,Ribosome biogenesis in eukaryotes;K14285,ko05164,Influenza A"]
["RANBP9",77.04861601,18.7963494,2.034719982,7.335151468,{"v":6.35e-18,"d":"6.35E-18"},{"v":3.51e-16,"d":"3.51E-16"},"ENSG00000010017","H2QSB6,RAN binding protein 9","XP_518246.4,ran-binding protein 9","PF10607,CTLH/CRA C-terminal to LisH motif domain;PF08513,LisH;PF00622,SPRY domain","IPR024964,CTLH/CRA C-terminal to LisH motif domain;IPR006594,LIS1 homology motif;IPR001870,B30.2/SPRY domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR006595,CTLH, C-terminal LisH motif;IPR035782,Ran binding protein 9/10, SPRY domain;IPR013144,CRA domain;IPR003877,SPRY domain","ENOG410XPCC,-;KOG1477,SPRY domain-containing proteins","GO:0005737,cellular_component,cytoplasm;GO:0019899,molecular_function,enzyme binding;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:0005634,cellular_component,nucleus","-"]
["RNF4",10.90944822,2.659166886,2.034591489,5.654080148,{"v":4.85e-13,"d":"4.85E-13"},{"v":9.45e-12,"d":"9.45E-12"},"ENSG00000063978","G3RGN2,Ring finger protein 4","-","PF13639,Ring finger domain","-","-","-","-"]
["GBAS",48.70223118,11.88656985,2.034096748,7.428540795,4.77E-18,2.73E-16,"ENSG00000146729","K7CE27,Glioblastoma amplified sequence","-","PF07978,NIPSNAP","IPR012577,NIPSNAP;IPR011008,Dimeric alpha-beta barrel","ENOG410XSWP,-;KOG2883,NIPSNAP1 protein","-","-"]
["AC007563.5",10.50708607,2.537216942,2.03377298,2.746232459,0.00041851,1.103749E-3,"ENSG00000236886","A0A096MXL3,Insulin like growth factor binding protein 5","XP_003907978.1,insulin-like growth factor-binding protein 5","PF00086,Thyroglobulin type-1 repeat;PF00219,Insulin-like growth factor binding protein","IPR022321,Insulin-like growth factor-binding protein family 1-6, chordata;IPR000716,Thyroglobulin type-1;IPR000867,Insulin-like growth factor-binding protein, IGFBP;IPR017891,Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR012213,Insulin-like growth factor binding protein 5;IPR036857,Thyroglobulin type-1 superfamily;IPR009168,Insulin-like growth factor binding protein","-","GO:0048662,biological_process,negative regulation of smooth muscle cell proliferation;GO:0043569,biological_process,negative regulation of insulin-like growth factor receptor signaling pathway;GO:0043568,biological_process,positive regulation of insulin-like growth factor receptor signaling pathway;GO:0014912,biological_process,negative regulation of smooth muscle cell migration;GO:0031994,molecular_function,insulin-like growth factor I binding;GO:0001649,biological_process,osteoblast differentiation;GO:0005520,molecular_function,insulin-like growth factor binding;GO:0005576,cellular_component,extracellular region;GO:0040008,biological_process,regulation of growth;GO:0051897,biological_process,positive regulation of protein kinase B signaling;GO:0060056,biological_process,mammary gland involution;GO:0042593,biological_process,glucose homeostasis;GO:1904205,biological_process,negative regulation of skeletal muscle hypertrophy;GO:0051146,biological_process,striated muscle cell differentiation;GO:0001968,molecular_function,fibronectin binding;GO:0030336,biological_process,negative regulation of cell migration;GO:0017148,biological_process,negative regulation of translation;GO:0006006,biological_process,glucose metabolic process;GO:1901862,biological_process,negative regulation of muscle tissue development;GO:0048286,biological_process,lung alveolus development;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0044342,biological_process,type B pancreatic cell proliferation;GO:0001558,biological_process,regulation of cell growth;GO:0042567,cellular_component,insulin-like growth factor ternary complex;GO:0045926,biological_process,negative regulation of growth;GO:0007565,biological_process,female pregnancy;GO:0031069,biological_process,hair follicle morphogenesis;GO:0010906,biological_process,regulation of glucose metabolic process;GO:0071320,biological_process,cellular response to cAMP;GO:0045668,biological_process,negative regulation of osteoblast differentiation","-"]
["EIF1B",4.967785466,1.199604663,2.03377298,2.746232459,0.00041851,1.103749E-3,"ENSG00000114784","A0A250XV20,Eukaryotic translation initiation factor 1b","XP_020033059.1,-","-","IPR036877,SUI1 domain superfamily;IPR005874,Eukaryotic translation initiation factor SUI1;IPR001950,SUI1 domain","-","GO:0006413,biological_process,translational initiation;GO:0003743,molecular_function,translation initiation factor activity","K03113,ko03013,RNA transport"]
["MEST",2.051048545,0.495280526,2.03377298,2.746232459,0.00041851,1.103749E-3,"ENSG00000106484","G1RQX4,Mesoderm specific transcript","XP_003261389.1,-;XP_003261388.1,-","PF12697,Alpha/beta hydrolase family;PF00561,alpha/beta hydrolase fold;PF06342,Alpha/beta hydrolase of unknown function (DUF1057)","IPR000639,Epoxide hydrolase-like;IPR000073,Alpha/beta hydrolase fold-1;IPR029058,Alpha/Beta hydrolase fold","ENOG410INNB,-;ENOG4111G38,-","GO:0003824,molecular_function,catalytic activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZMYND8",38.89675036,9.496868375,2.033607695,7.535896684,{"v":2.6E-18,"d":"2.60E-18"},1.58E-16,"ENSG00000101040","G3RD33,Zinc finger MYND-type containing 8","XP_018872739.1,protein kinase C-binding protein 1 isoform X2","PF12064,omain of unknown function (DUF3544);PF00439,Bromodomain;PF00855,PWWP domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000313,PWWP domain;IPR036427,Bromodomain-like superfamily;IPR021931,Protein kinase C-binding protein 1;IPR002893,Zinc finger, MYND-type;IPR001487,Bromodomain;IPR019787,Zinc finger, PHD-finger;IPR037967,RACK7, Bromo domain;IPR035505,ZMYND8/11, PWWP domain;IPR019786,Zinc finger, PHD-type, conserved site","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0046872,molecular_function,metal ion binding","-"]
["GOT2",28.87858379,7.047461246,2.033411174,6.102198907,{"v":1.48e-14,"d":"1.48E-14"},{"v":4.09e-13,"d":"4.09E-13"},"ENSG00000125166","H2QB89,Aspartate aminotransferase","XP_523381.2,aspartate aminotransferase, mitochondrial","PF00155,Aminotransferase class I and II","IPR015424,Pyridoxal phosphate-dependent transferase;IPR004839,Aminotransferase, class I/classII;IPR000796,Aspartate/other aminotransferase;IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR015422,Pyridoxal phosphate-dependent transferase domain 1;IPR004838,Aminotransferases, class-I, pyridoxal-phosphate-binding site","COG1448,Aspartate/tyrosine/aromatic aminotransferase;KOG1411,Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0015908,biological_process,fatty acid transport;GO:0006520,biological_process,cellular amino acid metabolic process;GO:0006533,biological_process,aspartate catabolic process;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0005886,cellular_component,plasma membrane;GO:0045471,biological_process,response to ethanol;GO:0009058,biological_process,biosynthetic process;GO:0004069,molecular_function,L-aspartate:2-oxoglutarate aminotransferase activity;GO:0008483,molecular_function,transaminase activity;GO:0005739,cellular_component,mitochondrion","K14455,ko00250,Alanine, aspartate and glutamate metabolism;K14455,ko01230,Biosynthesis of amino acids;K14455,ko04975,Fat digestion and absorption;K14455,ko00220,Arginine biosynthesis;K14455,ko00270,Cysteine and methionine metabolism;K14455,ko00950,Isoquinoline alkaloid biosynthesis;K14455,ko00710,Carbon fixation in photosynthetic organisms;K14455,ko00360,Phenylalanine metabolism;K14455,ko01200,Carbon metabolism;K14455,ko00400,Phenylalanine, tyrosine and tryptophan biosynthesis;K14455,ko00350,Tyrosine metabolism;K14455,ko00330,Arginine and proline metabolism;K14455,ko00960,Tropane, piperidine and pyridine alkaloid biosynthesis;K14455,ko01210,2-Oxocarboxylic acid metabolism"]
["C15orf39",4.861967875,1.18391816,2.032528486,4.210929783,{"v":4.33e-08,"d":"4.33E-08"},{"v":2.76e-07,"d":"2.76E-07"},"ENSG00000167173","G3RZ59,Chromosome 15 open reading frame 39","XP_018866751.1,-;XP_004056588.1,uncharacterized protein C15orf39 homolog","-","IPR037656,Uncharacterised protein C15orf39","-","GO:0005829,cellular_component,cytosol","-"]
["CTIF",2.990238867,0.728140989,2.031624676,3.999276089,{"v":3.56e-07,"d":"3.56E-07"},{"v":1.84E-6,"d":"1.84E-06"},"ENSG00000134030","K7D4L1,CBP80/20-dependent translation initiation factor","-","PF02854,MIF4G domain","IPR016024,Armadillo-type fold;IPR016021,MIF4G-like domain superfamily;IPR003890,MIF4G-like, type 3","ENOG410XQKW,-;KOG3942,MIF4G domain-containing protein","GO:0006413,biological_process,translational initiation;GO:0003743,molecular_function,translation initiation factor activity;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0003723,molecular_function,RNA binding;GO:0000184,biological_process,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006446,biological_process,regulation of translational initiation;GO:0005829,cellular_component,cytosol","-"]
["NUP43",5.465012369,1.330763089,2.031624676,3.999276089,{"v":3.56e-07,"d":"3.56E-07"},{"v":1.84E-6,"d":"1.84E-06"},"ENSG00000120253","H2QTW6,Nucleoporin 43kDa","-","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR037628,Nucleoporin Nup43","KOG4714,Nucleoporin;ENOG410ZTD5,-","GO:0031080,cellular_component,nuclear pore outer ring","K14305,ko03013,RNA transport"]
["GIT2",5.34820147,1.306588837,2.031130283,5.52629941,1.27E-12,{"v":2.26e-11,"d":"2.26E-11"},"ENSG00000139436","K7C3J8,G protein-coupled receptor kinase interacting ArfGAP 2","XP_016779649.1,-","PF12796,Ankyrin repeats (3 copies);PF01412,Putative GTPase activating protein for Arf;PF08518,Spa2 homology domain (SHD) of GIT;PF16559,IT coiled-coil Rho guanine nucleotide exchange factor;PF12205,protein-coupled receptor kinase-interacting protein 1 C term","IPR013724,GIT, Spa2 homology (SHD) domain;IPR037278,ARFGAP/RecO-like zinc finger;IPR038508,ArfGAP domain superfamily;IPR032352,Arf GTPase-activating protein GIT1/2, coiled-coil domain;IPR022018,ARF GTPase-activating protein GIT1, C-terminal;IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR001164,Arf GTPase activating protein;IPR002110,Ankyrin repeat","KOG0818,GTPase-activating proteins of the GIT family;ENOG410XR8U,-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0046872,molecular_function,metal ion binding;GO:0005096,molecular_function,GTPase activator activity","-"]
["RP11-467L13.7",2.615700834,0.627707749,2.030697287,2.045538816,0.006629955,0.013195135,"ENSG00000276900","A0A2B7UTA5,Uncharacterized protein","-","-","-","-","-","-"]
["CDAN1",1.006187056,0.24146164,2.030697287,2.045538816,0.006629955,0.013195135,"ENSG00000140326","K7ARJ7,Congenital dyserythropoietic anemia, type I","XP_016783546.1,codanin-1 isoform X3","PF15296,Codanin-1 C-terminus","IPR028171,Codanin-1, C-terminal domain","ENOG410XXWY,-;ENOG410IGHV,-","-","-"]
["RP4-681N20.5",8.163801706,1.959123737,2.030697287,2.045538816,0.006629955,0.013195135,"ENSG00000275582","G7NQ99,Uncharacterized protein","-","-","-","-","-","-"]
["MRAS",0.85806494,0.205915755,2.030697287,2.045538816,0.006629955,0.013195135,"ENSG00000158186","A0A0P6J237,Ras-related protein M-Ras isoform 1","XP_004834369.1,-;XP_004834373.1,-;XP_004834372.1,-;XP_004834374.1,-;XP_004834371.1,-;XP_004834370.1,-","PF00071,Ras family","IPR020849,Small GTPase superfamily, Ras type;IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005525,molecular_function,GTP binding;GO:0030742,molecular_function,GTP-dependent protein binding;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0007165,biological_process,signal transduction","K07831,ko04014,Ras signaling pathway;K07831,ko05166,HTLV-I infection;K07831,ko04072,Phospholipase D signaling pathway;K07831,ko05205,Proteoglycans in cancer;K07831,ko04810,Regulation of actin cytoskeleton;K07831,ko04010,MAPK signaling pathway;K07831,ko04015,Rap1 signaling pathway;K07831,ko04530,Tight junction"]
["CTC-351M12.1",1.765217628,0.423611435,2.030697287,2.045538816,0.006629955,0.013195135,"ENSG00000280187","F6UL03,Uncharacterized protein","-","-","-","-","GO:0070509,biological_process,calcium ion import;GO:0006851,biological_process,mitochondrial calcium ion transmembrane transport;GO:0051561,biological_process,positive regulation of mitochondrial calcium ion concentration;GO:0031305,cellular_component,integral component of mitochondrial inner membrane","-"]
["FBXL4",0.673023209,0.161510016,2.030697287,2.045538816,0.006629955,0.013195135,"ENSG00000112234","H2QTF8,F-box and leucine-rich repeat protein 4","XP_518648.2,-;XP_001136579.1,F-box/LRR-repeat protein 4 isoform X1","PF00646,-box domain","IPR006553,Leucine-rich repeat, cysteine-containing subtype;IPR036047,F-box-like domain superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR001810,F-box domain","KOG1947,Leucine rich repeat proteins, some proteins contain F-box;ENOG410XQ54,-","GO:0005758,cellular_component,mitochondrial intermembrane space;GO:0016607,cellular_component,nuclear speck","-"]
["THSD7A",0.499733127,0.119924401,2.030697287,2.045538816,0.006629955,0.013195135,"ENSG00000005108","A0A087WY08,Thrombospondin type-1 domain-containing protein 7A","-","PF00090,Thrombospondin type 1 domain","IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","ENOG410INDB,-;ENOG410XR0P,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CCDC86",31.48321887,7.694640589,2.030274781,5.359659494,{"v":6.22e-12,"d":"6.22E-12"},{"v":9.32e-11,"d":"9.32E-11"},"ENSG00000110104","G2HE85,Coiled-coil domain containing 86","NP_001233482.1,coiled-coil domain-containing protein 86","PF03879,Cgr1 family","IPR026570,Coiled-coil domain-containing protein 86;IPR005579,Cgr1-like","ENOG41129IK,-;KOG4538,Predicted coiled-coil protein","GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus","-"]
["TBC1D16",2.671555075,0.652207636,2.029310035,4.333526908,{"v":2.22E-8,"d":"2.22E-08"},{"v":1.51e-07,"d":"1.51E-07"},"ENSG00000167291","K7CY49,TBC1 domain family, member 16","XP_009431716.2,-;XP_009431717.2,-;XP_009431718.2,-;XP_001159856.2,TBC1 domain family member 16 isoform X1","PF00566,Rab-GTPase-TBC domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain","KOG2224,Uncharacterized conserved protein, contains TBC domain;COG5210,GTPase-activating protein","GO:0005829,cellular_component,cytosol;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0001919,biological_process,regulation of receptor recycling;GO:0005769,cellular_component,early endosome;GO:0005096,molecular_function,GTPase activator activity","-"]
["KDF1",9.005738918,2.19295111,2.02846867,3.449263743,{"v":8.76e-06,"d":"8.76E-06"},{"v":3.37e-05,"d":"3.37E-05"},"ENSG00000175707","H2PYE8,Uncharacterized protein","XP_016812533.1,-;XP_001146912.1,keratinocyte differentiation factor 1;XP_016812530.1,-","PF15551,omain of unknown function (DUF4656)","IPR028003,Keratinocyte differentiation factor 1","ENOG4111J7A,-;ENOG410IKUD,-","GO:0003334,biological_process,keratinocyte development;GO:0010482,biological_process,regulation of epidermal cell division;GO:0030054,cellular_component,cell junction;GO:0016331,biological_process,morphogenesis of embryonic epithelium;GO:0061436,biological_process,establishment of skin barrier;GO:0005737,cellular_component,cytoplasm;GO:0005938,cellular_component,cell cortex;GO:0031252,cellular_component,cell leading edge;GO:0045606,biological_process,positive regulation of epidermal cell differentiation;GO:0048589,biological_process,developmental growth;GO:0060887,biological_process,limb epidermis development;GO:0072686,cellular_component,mitotic spindle;GO:0010839,biological_process,negative regulation of keratinocyte proliferation;GO:2000647,biological_process,negative regulation of stem cell proliferation;GO:0005654,cellular_component,nucleoplasm","-"]
["USP30",3.144554991,0.765717885,2.02846867,3.449263743,{"v":8.76e-06,"d":"8.76E-06"},{"v":3.37e-05,"d":"3.37E-05"},"ENSG00000135093","H2Q6T9,Ubiquitin specific peptidase 30","XP_016802017.1,-;XP_001135207.1,-","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","KOG1867,Ubiquitin-specific protease;ENOG410XQQ0,-","GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016579,biological_process,protein deubiquitination;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MBD2",46.71548125,11.44848182,2.028181013,7.409754479,{"v":5.73e-18,"d":"5.73E-18"},{"v":3.21e-16,"d":"3.21E-16"},"ENSG00000134046","G3RC55,Methyl-CpG binding domain protein 2","XP_004059488.1,methyl-CpG-binding domain protein 2 isoform X1","PF16564,p55-binding region of Methyl-CpG-binding domain proteins MBD;PF14048,C-terminal domain of methyl-CpG binding protein 2 and 3;PF01429,Methyl-CpG binding domain","IPR032343,Methyl-CpG-binding domain protein 2/3, p55-binding region;IPR001739,Methyl-CpG DNA binding;IPR025884,Methyl-CpG binding protein 2/3, C-terminal domain;IPR016177,DNA-binding domain superfamily","-","GO:0042127,biological_process,regulation of cell proliferation;GO:0006346,biological_process,methylation-dependent chromatin silencing;GO:0000118,cellular_component,histone deacetylase complex;GO:0000785,cellular_component,chromatin;GO:0000792,cellular_component,heterochromatin;GO:0000790,cellular_component,nuclear chromatin;GO:0019904,molecular_function,protein domain specific binding;GO:0042711,biological_process,maternal behavior;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0070742,molecular_function,C2H2 zinc finger domain binding;GO:0030177,biological_process,positive regulation of Wnt signaling pathway;GO:0005737,cellular_component,cytoplasm;GO:0008327,molecular_function,methyl-CpG binding;GO:0005829,cellular_component,cytosol;GO:0003677,molecular_function,DNA binding;GO:0003729,molecular_function,mRNA binding;GO:0035197,molecular_function,siRNA binding;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","-"]
["DGKG",3.049907131,0.746182012,2.026598816,4.446448361,{"v":8.27e-09,"d":"8.27E-09"},{"v":6.19e-08,"d":"6.19E-08"},"ENSG00000058866","H2QNW8,Diacylglycerol kinase","XP_001152821.1,diacylglycerol kinase gamma isoform X1","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF00781,iacylglycerol kinase catalytic domain;PF00609,iacylglycerol kinase accessory domain;PF14513,iacylglycerol kinase N-terminus","IPR017438,Inorganic polyphosphate/ATP-NAD kinase, N-terminal;IPR018247,EF-Hand 1, calcium-binding site;IPR000756,Diacylglycerol kinase, accessory domain;IPR001206,Diacylglycerol kinase, catalytic domain;IPR011992,EF-hand domain pair;IPR029477,Diacylglycerol kinase type I, N-terminal;IPR002048,EF-hand domain;IPR038199,DGK type I, N-terminal domain superfamily;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR016064,NAD kinase/diacylglycerol kinase-like domain superfamily;IPR037607,Diacylglycerol kinase","ENOG410XQVB,-;KOG1169,Diacylglycerol kinase","GO:0016301,molecular_function,kinase activity;GO:0004143,molecular_function,diacylglycerol kinase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0007205,biological_process,protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0046486,biological_process,glycerolipid metabolic process;GO:0016740,molecular_function,transferase activity;GO:0005509,molecular_function,calcium ion binding;GO:0005524,molecular_function,ATP binding;GO:0007165,biological_process,signal transduction;GO:0008152,biological_process,metabolic process;GO:0005622,cellular_component,intracellular;GO:0046834,biological_process,lipid phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0003951,molecular_function,NAD+ kinase activity","-"]
["MXRA7",1.308249693,0.318566599,2.025324011,3.066093443,0.000153408,0.000446759,"ENSG00000182534","Q6ZR64,HBV PreS1-transactivated protein 1","XP_005257441.1,matrix-remodeling-associated protein 7 isoform X3;NP_001008529.1,matrix-remodeling-associated protein 7 isoform 2 precursor","-","IPR026622,Matrix-remodeling-associated protein 7","-","-","-"]
["CBLL1",15.33678005,3.766246495,2.023983324,5.738416215,{"v":3.54e-13,"d":"3.54E-13"},{"v":7.18e-12,"d":"7.18E-12"},"ENSG00000105879","H2QV82,Cas-Br-M","XP_001148913.2,-","-","IPR001841,Zinc finger, RING-type;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XQ6S,-;KOG2932,E3 ubiquitin ligase involved in ubiquitination of E-cadherin complex","GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0007162,biological_process,negative regulation of cell adhesion;GO:0098609,biological_process,cell-cell adhesion;GO:0016567,biological_process,protein ubiquitination;GO:0030155,biological_process,regulation of cell adhesion;GO:0045807,biological_process,positive regulation of endocytosis;GO:0016607,cellular_component,nuclear speck;GO:0042802,molecular_function,identical protein binding;GO:0030335,biological_process,positive regulation of cell migration","-"]
["KIAA1958",1.936750937,0.474548781,2.023008768,4.066414451,{"v":1.72E-7,"d":"1.72E-07"},{"v":9.6e-07,"d":"9.60E-07"},"ENSG00000165185","H2R0H1,KIAA1958","XP_003312263.1,uncharacterized protein KIAA1958 homolog isoform X2","PF12012,omain of unknown function (DUF3504)","IPR021893,Protein of unknown function DUF3504","ENOG410XWKQ,-;ENOG410IHMV,-","GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005654,cellular_component,nucleoplasm","-"]
["TFDP2",8.063705026,1.983001433,2.022171325,5.926105188,{"v":9.35e-14,"d":"9.35E-14"},{"v":2.15e-12,"d":"2.15E-12"},"ENSG00000114126","K7BZM2,Transcription factor Dp-2","XP_009444757.1,-","PF02319,2F/DP family winged-helix DNA-binding domain;PF08781,Transcription factor DP","IPR003316,E2F/DP family, winged-helix DNA-binding domain;IPR038168,Transcription factor DP, C-terminal domain superfamily;IPR028314,Transcription factor DP2;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR037241,E2F-DP heterodimerization region;IPR015648,Transcription factor DP;IPR036390,Winged helix DNA-binding domain superfamily;IPR014889,Transcription factor DP, C-terminal","ENOG410Y9QP,-;KOG2829,E2F-like protein","GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0003712,molecular_function,transcription cofactor activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0007049,biological_process,cell cycle;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0000278,biological_process,mitotic cell cycle;GO:0005634,cellular_component,nucleus","-"]
["COG1",14.02341276,3.451034968,2.020698578,5.569358598,{"v":1.64e-12,"d":"1.64E-12"},{"v":2.83e-11,"d":"2.83E-11"},"ENSG00000166685","K7CEZ8,Component of oligomeric golgi complex 1","-","PF08700,Vps51/Vps67","-","-","-","-"]
["MED25",10.01057475,2.462829816,2.020655431,5.292191562,{"v":1.55e-11,"d":"1.55E-11"},{"v":2.14e-10,"d":"2.14E-10"},"ENSG00000104973","G3SBH5,Mediator complex subunit 25","-","PF11244,Mediator complex subunit 25 C-terminal NR box-containing;PF11265,Mediator complex subunit 25 von Willebrand factor type A;PF11235,Mediator complex subunit 25 synapsin 1;PF11232,Mediator complex subunit 25 PTOV activation and synapsin 2","IPR021397,Mediator complex, subunit Med25, synapsin 1;IPR036465,von Willebrand factor A-like domain superfamily;IPR021394,Mediator complex, subunit Med25, PTOV domain;IPR021419,Mediator complex, subunit Med25, von Willebrand factor type A;IPR021406,Mediator complex, subunit Med25, NR box;IPR038196,PTOV domain superfamily","-","-","-"]
["ALCAM",5.755406781,1.414899958,2.020538686,4.739989794,{"v":1.45E-9,"d":"1.45E-09"},{"v":1.29E-8,"d":"1.29E-08"},"ENSG00000170017","H2R846,Activated leukocyte cell adhesion molecule","-","PF13927,Immunoglobulin domain;PF08205,CD80-like C2-set immunoglobulin domain","IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR007110,Immunoglobulin-like domain","ENOG410IFQ2,-;ENOG410ZWU9,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SLC46A1",1.87835277,0.459849183,2.01989226,3.326800095,{"v":2.19E-5,"d":"2.19E-05"},{"v":7.75E-5,"d":"7.75E-05"},"ENSG00000076351","A0A024QZ15,Heme carrier protein 1, isoform CRA_a","NP_542400.2,proton-coupled folate transporter isoform 1","-","IPR036259,MFS transporter superfamily;IPR011701,Major facilitator superfamily;IPR020846,Major facilitator superfamily domain;IPR005829,Sugar transporter, conserved site","ENOG410ZVCA,-;KOG2816,Predicted transporter ADD1 (major facilitator superfamily)","GO:0015232,molecular_function,heme transporter activity;GO:0008517,molecular_function,folic acid transmembrane transporter activity;GO:0031526,cellular_component,brush border membrane;GO:0005737,cellular_component,cytoplasm;GO:0015884,biological_process,folic acid transport;GO:0015886,biological_process,heme transport;GO:0055085,biological_process,transmembrane transport;GO:0016324,cellular_component,apical plasma membrane;GO:0016020,cellular_component,membrane;GO:0005215,molecular_function,transporter activity;GO:0051958,biological_process,methotrexate transport;GO:0016021,cellular_component,integral component of membrane;GO:0015350,molecular_function,methotrexate transmembrane transporter activity","-"]
["PTPRZ1",1.484574872,0.363446395,2.01989226,3.326800095,{"v":2.19E-5,"d":"2.19E-05"},{"v":7.75E-5,"d":"7.75E-05"},"ENSG00000106278","H2R4Z7,Uncharacterized protein","XP_001144786.1,receptor-type tyrosine-protein phosphatase zeta isoform X1","PF00102,Protein-tyrosine phosphatase;PF00041,ibronectin type III domain;PF00194,ukaryotic-type carbonic anhydrase","IPR003961,Fibronectin type III;IPR029021,Protein-tyrosine phosphatase-like;IPR000387,Tyrosine specific protein phosphatases domain;IPR000242,PTP type protein phosphatase;IPR036116,Fibronectin type III superfamily;IPR001148,Alpha carbonic anhydrase;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR036398,Alpha carbonic anhydrase superfamily;IPR013783,Immunoglobulin-like fold;IPR016130,Protein-tyrosine phosphatase, active site","COG3338,Carbonic anhydrase;COG5599,Protein tyrosine phosphatase;KOG4228,Protein tyrosine phosphatase","GO:0048709,biological_process,oligodendrocyte differentiation;GO:0016787,molecular_function,hydrolase activity;GO:0005578,,;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0006470,biological_process,protein dephosphorylation;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0072534,cellular_component,perineuronal net;GO:0070445,biological_process,regulation of oligodendrocyte progenitor proliferation;GO:0007409,biological_process,axonogenesis;GO:0007611,biological_process,learning or memory;GO:0016020,cellular_component,membrane;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0016311,biological_process,dephosphorylation;GO:0016021,cellular_component,integral component of membrane;GO:0016791,molecular_function,phosphatase activity","K08114,ko05120,Epithelial cell signaling in Helicobacter pylori infection"]
["RP11-688G15.3",9.081715343,2.211451823,2.019068459,2.538751558,1.289255E-3,0.003026694,"-","-","-","-","-","-","-","-"]
["LRRC24",4.556233036,1.109469904,2.019068459,2.538751558,1.289255E-3,0.003026694,"ENSG00000254402","G3V1D8,Leucine rich repeat containing 24","-","PF13927,Immunoglobulin domain;PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR000483,Cysteine-rich flanking region, C-terminal;IPR032675,Leucine-rich repeat domain superfamily;IPR000372,Leucine-rich repeat N-terminal domain;IPR036179,Immunoglobulin-like domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR007110,Immunoglobulin-like domain","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SOX12",15.79648483,3.892330341,2.018823434,5.542442952,1.46E-12,{"v":2.54e-11,"d":"2.54E-11"},"ENSG00000177732","K7A3P9,SRY","-","PF00505,HMG (high mobility group) box","IPR031267,Transcription factor SOX-12;IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily;IPR017386,Transcription factor SOX-11/4","-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0003677,molecular_function,DNA binding;GO:0045165,biological_process,cell fate commitment;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001105,molecular_function,RNA polymerase II transcription coactivator activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["ATR",2.451373139,0.603093729,2.018181934,4.324843939,{"v":2.85E-8,"d":"2.85E-08"},{"v":1.89e-07,"d":"1.89E-07"},"ENSG00000175054","K7DR10,Ataxia telangiectasia and Rad3 related","XP_016797579.1,serine/threonine-protein kinase ATR isoform X2","PF02259,AT domain;PF00454,Phosphatidylinositol 3- and 4-kinase;PF02260,ATC domain;PF08064,UME (NUC010) domain","IPR018936,Phosphatidylinositol 3/4-kinase, conserved site;IPR003151,PIK-related kinase, FAT;IPR003152,FATC domain;IPR012993,UME domain;IPR000403,Phosphatidylinositol 3-/4-kinase, catalytic domain;IPR014009,PIK-related kinase;IPR011989,Armadillo-like helical;IPR011009,Protein kinase-like domain superfamily;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR021133,HEAT, type 2;IPR016024,Armadillo-type fold;IPR036940,Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily","KOG0890,Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination;COG5032,Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family","GO:0034644,biological_process,cellular response to UV;GO:0070198,biological_process,protein localization to chromosome, telomeric region;GO:0004672,molecular_function,protein kinase activity;GO:0000077,biological_process,DNA damage checkpoint;GO:0016310,biological_process,phosphorylation;GO:0097694,biological_process,establishment of RNA localization to telomere;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0016301,molecular_function,kinase activity;GO:0005524,molecular_function,ATP binding;GO:0008156,biological_process,negative regulation of DNA replication;GO:0016605,cellular_component,PML body;GO:0090399,biological_process,replicative senescence;GO:1904884,biological_process,positive regulation of telomerase catalytic core complex assembly;GO:0016740,molecular_function,transferase activity;GO:0000166,molecular_function,nucleotide binding;GO:0071480,biological_process,cellular response to gamma radiation;GO:0005654,cellular_component,nucleoplasm;GO:0032405,molecular_function,MutLalpha complex binding;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0046777,biological_process,protein autophosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005794,cellular_component,Golgi apparatus;GO:0043517,biological_process,positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0032407,molecular_function,MutSalpha complex binding","-"]
["SNX13",4.208850181,1.037793833,2.017713218,5.462458673,{"v":3.36e-12,"d":"3.36E-12"},{"v":5.37e-11,"d":"5.37E-11"},"ENSG00000071189","A0A024R9Z9,Sorting nexin 13, isoform CRA_b","NP_055947.1,sorting nexin-13 isoform b","PF02194,PXA domain;PF00615,Regulator of G protein signaling domain;PF08628,Sorting nexin C terminal;PF00787,PX domain","IPR013937,Sorting nexin, C-terminal;IPR036305,RGS domain superfamily;IPR036871,PX domain superfamily;IPR003114,Phox-associated domain;IPR037896,SNX13, RGS domain;IPR037437,Sorting nexin-13, PX domain;IPR001683,Phox homologous domain;IPR016137,RGS domain","ENOG410IMHZ,-;ENOG410XRJ0,-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CASP3",8.273016445,2.03447465,2.017431087,3.988268751,{"v":3.56e-07,"d":"3.56E-07"},{"v":1.84E-6,"d":"1.84E-06"},"ENSG00000164305","K7D0A9,Caspase 3, apoptosis-related cysteine peptidase","XP_009446812.1,-;XP_016806492.1,-;XP_016806491.1,-;XP_009446814.1,-;NP_001012435.1,caspase-3;XP_016806493.1,-","PF00656,Caspase domain","IPR016129,Peptidase family C14A, His active site;IPR002138,Peptidase C14, caspase non-catalytic subunit p10;IPR001309,Peptidase C14,  p20 domain;IPR015917,Peptidase C14A, caspase catalytic domain;IPR029030,Caspase-like domain superfamily;IPR033139,Peptidase family C14A, cysteine active site","ENOG410ZQIE,-;KOG3573,Caspase, apoptotic cysteine protease","GO:0009411,biological_process,response to UV;GO:0048011,biological_process,neurotrophin TRK receptor signaling pathway;GO:0004190,molecular_function,aspartic-type endopeptidase activity;GO:0030218,biological_process,erythrocyte differentiation;GO:0010033,biological_process,response to organic substance;GO:0005634,cellular_component,nucleus;GO:0043029,biological_process,T cell homeostasis;GO:0016787,molecular_function,hydrolase activity;GO:0007507,biological_process,heart development;GO:0045786,biological_process,negative regulation of cell cycle;GO:0005737,cellular_component,cytoplasm;GO:0007605,biological_process,sensory perception of sound;GO:0071310,biological_process,cellular response to organic substance;GO:0034349,biological_process,glial cell apoptotic process;GO:0072734,biological_process,cellular response to staurosporine;GO:0008233,molecular_function,peptidase activity;GO:0051402,biological_process,neuron apoptotic process;GO:0006915,biological_process,apoptotic process;GO:0045165,biological_process,cell fate commitment;GO:0006508,biological_process,proteolysis;GO:0097194,biological_process,execution phase of apoptosis;GO:0016485,biological_process,protein processing;GO:0046007,biological_process,negative regulation of activated T cell proliferation;GO:0008627,biological_process,intrinsic apoptotic signaling pathway in response to osmotic stress;GO:0005829,cellular_component,cytosol;GO:0004861,molecular_function,cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0097153,molecular_function,cysteine-type endopeptidase activity involved in apoptotic process;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0045736,biological_process,negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0009611,biological_process,response to wounding;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0030889,biological_process,negative regulation of B cell proliferation;GO:0004197,molecular_function,cysteine-type endopeptidase activity;GO:0097200,molecular_function,cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:0030216,biological_process,keratinocyte differentiation;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0001782,biological_process,B cell homeostasis","K02187,ko05205,Proteoglycans in cancer;K02187,ko05200,Pathways in cancer;K02187,ko05206,MicroRNAs in cancer;K02187,ko04650,Natural killer cell mediated cytotoxicity;K02187,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K02187,ko05168,Herpes simplex infection;K02187,ko05016,Huntington's disease;K02187,ko04010,MAPK signaling pathway;K02187,ko05133,Pertussis;K02187,ko05146,Amoebiasis;K02187,ko05161,Hepatitis B;K02187,ko05210,Colorectal cancer;K02187,ko05012,Parkinson's disease;K02187,ko04215,Apoptosis - multiple species;K02187,ko04115,p53 signaling pathway;K02187,ko05152,Tuberculosis;K02187,ko05203,Viral carcinogenesis;K02187,ko04210,Apoptosis;K02187,ko04933,AGE-RAGE signaling pathway in diabetic complications;K02187,ko05134,Legionellosis;K02187,ko05014,Amyotrophic lateral sclerosis (ALS);K02187,ko05145,Toxoplasmosis;K02187,ko04726,Serotonergic synapse;K02187,ko01524,Platinum drug resistance;K02187,ko04932,Non-alcoholic fatty liver disease (NAFLD);K02187,ko05010,Alzheimer's disease;K02187,ko05416,Viral myocarditis;K02187,ko04668,TNF signaling pathway"]
["AGK",2.647715076,0.65062239,2.016106344,3.546946175,{"v":1e-05,"d":"1.00E-05"},{"v":3.81e-05,"d":"3.81E-05"},"ENSG00000006530","A4D1U5,Multiple substrate lipid kinase, isoform CRA_a","XP_011514699.1,-;NP_060708.1,acylglycerol kinase, mitochondrial precursor","PF00781,iacylglycerol kinase catalytic domain","IPR017438,Inorganic polyphosphate/ATP-NAD kinase, N-terminal;IPR001206,Diacylglycerol kinase, catalytic domain;IPR016064,NAD kinase/diacylglycerol kinase-like domain superfamily","KOG4435,Predicted lipid kinase;COG1597,Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase","GO:0001727,molecular_function,lipid kinase activity;GO:0016301,molecular_function,kinase activity;GO:0046513,biological_process,ceramide biosynthetic process;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0001729,molecular_function,ceramide kinase activity;GO:0046834,biological_process,lipid phosphorylation;GO:0016310,biological_process,phosphorylation;GO:0003951,molecular_function,NAD+ kinase activity","K09881,ko00561,Glycerolipid metabolism"]
["CTD-2369P2.12",14.37596555,3.542307514,2.01520567,4.130543828,{"v":1.12E-7,"d":"1.12E-07"},{"v":6.48e-07,"d":"6.48E-07"},"ENSG00000267303","H2QFB5,Ribonucleoprotein, PTB binding 1","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","-","-","-","-"]
["NOL4L",3.795139917,0.936379447,2.014770001,4.54367118,{"v":5.87e-09,"d":"5.87E-09"},{"v":4.55e-08,"d":"4.55E-08"},"ENSG00000197183","H2R925,Uncharacterized protein","XP_016793166.1,-","-","IPR026746,Nucleolar protein 4-like","ENOG410IHZD,-;ENOG410YIBB,-","GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm","-"]
["MADD",6.812148562,1.684141542,2.013447414,5.19176672,3.08E-11,{"v":3.96e-10,"d":"3.96E-10"},"ENSG00000110514","G3QZT3,MAP kinase activating death domain","XP_004051105.1,MAP kinase-activating death domain protein isoform X3","PF02141,NN (AEX-3) domain;PF03456,uDENN domain","IPR001194,cDENN domain;IPR005113,uDENN domain;IPR037516,Tripartite DENN domain;IPR005112,dDENN domain","-","GO:0000187,biological_process,activation of MAPK activity;GO:1902041,biological_process,regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0042981,biological_process,regulation of apoptotic process;GO:0097194,biological_process,execution phase of apoptosis;GO:2001236,biological_process,regulation of extrinsic apoptotic signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0032483,biological_process,regulation of Rab protein signal transduction;GO:0051726,biological_process,regulation of cell cycle;GO:0005829,cellular_component,cytosol;GO:0017112,molecular_function,Rab guanyl-nucleotide exchange factor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["ZIC1",1.570042101,0.385146571,2.013142732,2.903266978,0.000205848,0.000583223,"ENSG00000152977","H0XK46,Zic family member 1","XP_003789515.1,zinc finger protein ZIC 1","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0005634,cellular_component,nucleus;GO:0007420,biological_process,brain development","-"]
["EHHADH",2.273554582,0.557725013,2.013142732,2.903266978,0.000205848,0.000583223,"ENSG00000113790","H2QNW2,Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase","XP_517004.2,peroxisomal bifunctional enzyme isoform X1","PF02737,3-hydroxyacyl-CoA dehydrogenase, NAD binding domain;PF00725,3-hydroxyacyl-CoA dehydrogenase, C-terminal domain;PF00378,noyl-CoA hydratase/isomerase","IPR036291,NAD(P)-binding domain superfamily;IPR006108,3-hydroxyacyl-CoA dehydrogenase, C-terminal;IPR006180,3-hydroxyacyl-CoA dehydrogenase, conserved site;IPR018376,Enoyl-CoA hydratase/isomerase, conserved site;IPR001753,Enoyl-CoA hydratase/isomerase;IPR029045,ClpP/crotonase-like domain superfamily;IPR006176,3-hydroxyacyl-CoA dehydrogenase, NAD binding;IPR008927,6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily","COG1024,Enoyl-CoA hydratase/carnithine racemase;COG1250,3-hydroxyacyl-CoA dehydrogenase;KOG1683,Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase","GO:0006631,biological_process,fatty acid metabolic process;GO:0019899,molecular_function,enzyme binding;GO:0005777,cellular_component,peroxisome;GO:0003824,molecular_function,catalytic activity;GO:0005102,molecular_function,signaling receptor binding;GO:0006635,biological_process,fatty acid beta-oxidation;GO:0016491,molecular_function,oxidoreductase activity;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0006475,biological_process,internal protein amino acid acetylation;GO:0003857,molecular_function,3-hydroxyacyl-CoA dehydrogenase activity","-"]
["CDV3",140.7251788,34.88974169,2.011760581,8.586988785,1.43E-19,{"v":1.1E-17,"d":"1.10E-17"},"ENSG00000091527","D3DND1,CDV3 homolog","-","PF15359,Carnitine deficiency-associated protein 3","IPR026806,Protein CDV3","-","-","-"]
["RARA",7.277894962,1.800729142,2.010564353,4.488141495,{"v":7.36e-09,"d":"7.36E-09"},{"v":5.58e-08,"d":"5.58E-08"},"ENSG00000131759","A8MUP8,Retinoic acid receptor alpha","XP_005257609.1,retinoic acid receptor alpha isoform X4","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR003078,Retinoic acid receptor;IPR013088,Zinc finger, NHR/GATA-type","-","GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0003708,molecular_function,retinoic acid receptor activity;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0015629,cellular_component,actin cytoskeleton;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0048384,biological_process,retinoic acid receptor signaling pathway;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway","-"]
["DNAJC4",4.737359507,1.167308319,2.009550825,3.192732631,{"v":5.69e-05,"d":"5.69E-05"},1.8217E-4,"ENSG00000110011","J3KNJ8,DnaJ homolog subfamily C member 4","NP_001294909.1,dnaJ homolog subfamily C member 4 isoform 1","PF00226,naJ domain","IPR036869,Chaperone J-domain superfamily;IPR001623,DnaJ domain","ENOG410KDCY,-;COG0484,DnaJ-class molecular chaperone with C-terminal Zn finger domain","GO:0005739,cellular_component,mitochondrion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-840I19.3",18.27943021,4.52113686,2.009480649,4.055919679,{"v":2.26e-07,"d":"2.26E-07"},{"v":1.23e-06,"d":"1.23E-06"},"ENSG00000259118","H0XNX5,MYC associated factor X","-","PF00010,Helix-loop-helix DNA-binding domain","IPR037933,Protein max;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","ENOG4111V1C,-;KOG2483,Upstream transcription factor 2/L-myc-2 protein","GO:0070888,molecular_function,E-box binding;GO:0032993,cellular_component,protein-DNA complex;GO:0003677,molecular_function,DNA binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0046983,molecular_function,protein dimerization activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0071339,cellular_component,MLL1 complex;GO:0000790,cellular_component,nuclear chromatin;GO:0090575,cellular_component,RNA polymerase II transcription factor complex;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["OAS3",3.367208459,0.833951321,2.008105445,4.191923511,{"v":7.33e-08,"d":"7.33E-08"},{"v":4.43e-07,"d":"4.43E-07"},"ENSG00000111331","A8KA84,cDNA FLJ78682, highly similar to Homo sapiens 2'-5'-oligoadenylate synthetase 3, 100kDa","-","PF10421,2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus;PF01909,Nucleotidyltransferase domain","IPR006117,2-5-oligoadenylate synthetase, conserved site;IPR006116,2-5-oligoadenylate synthetase, N-terminal;IPR002934,Polymerase, nucleotidyl transferase domain;IPR026774,2'-5'-oligoadenylate synthase;IPR018952,2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal;IPR038121,2'-5'-oligoadenylate synthetase, domain 2 superfamily","COG5272,Ubiquitin;KOG0001,Ubiquitin and ubiquitin-like proteins","GO:0051607,biological_process,defense response to virus;GO:0016740,molecular_function,transferase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0003723,molecular_function,RNA binding;GO:0006955,biological_process,immune response;GO:0003725,molecular_function,double-stranded RNA binding;GO:0005524,molecular_function,ATP binding","-"]
["RLF",13.30628416,3.304962703,2.007595634,5.725433291,{"v":5.38e-13,"d":"5.38E-13"},{"v":1.03e-11,"d":"1.03E-11"},"ENSG00000117000","H2PYR7,Rearranged L-myc fusion","XP_524678.1,zinc finger protein Rlf","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0044030,biological_process,regulation of DNA methylation;GO:0015074,biological_process,DNA integration;GO:0097692,biological_process,histone H3-K4 monomethylation;GO:0051276,biological_process,chromosome organization","-"]
["MARVELD2",9.162916998,2.27451146,2.006905745,4.857986097,{"v":4.88e-10,"d":"4.88E-10"},{"v":4.84e-09,"d":"4.84E-09"},"ENSG00000152939","G3RHQ2,MARVEL domain containing 2","XP_018868973.1,MARVEL domain-containing protein 2 isoform X2","PF01284,Membrane-associating domain;PF07303,Occludin homology domain","IPR031176,ELL/occludin family;IPR010844,Occludin homology domain;IPR031177,MARVEL domain-containing protein 2;IPR008253,Marvel domain","-","GO:0070830,biological_process,bicellular tight junction assembly;GO:0030054,cellular_component,cell junction;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0005923,cellular_component,bicellular tight junction;GO:0045216,biological_process,cell-cell junction organization;GO:0005737,cellular_component,cytoplasm;GO:0007605,biological_process,sensory perception of sound;GO:0016324,cellular_component,apical plasma membrane;GO:0061689,cellular_component,tricellular tight junction;GO:0016323,cellular_component,basolateral plasma membrane;GO:0061028,biological_process,establishment of endothelial barrier;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["FAM127A",27.94831515,6.936144053,2.006009854,4.430369687,{"v":1.34e-08,"d":"1.34E-08"},{"v":9.62e-08,"d":"9.62E-08"},"ENSG00000134590","U3CRC1,Protein FAM127A","XP_002763335.1,-","PF16297,omain of unknown function (DUF4939)","IPR032567,LDOC1-related;IPR032549,Domain of unknown function DUF4939","-","-","-"]
["THADA",1.302524004,0.322594109,2.005411784,3.638358134,{"v":4.25E-6,"d":"4.25E-06"},{"v":1.76e-05,"d":"1.76E-05"},"ENSG00000115970","H2QHT7,Thyroid adenoma associated","-","PF10350,Putative death-receptor fusion protein (DUF2428)","IPR016024,Armadillo-type fold;IPR019442,Domain of unknown function DUF2428, death-receptor-like","COG5543,Uncharacterized conserved protein;KOG1810,Cell cycle-associated protein","-","-"]
["TECPR2",4.07407112,1.012600161,2.004488364,4.634725426,{"v":3.01e-09,"d":"3.01E-09"},{"v":2.48E-8,"d":"2.48E-08"},"ENSG00000196663","K7APF2,Tectonin beta-propeller repeat containing 2","-","PF06462,Propeller","IPR029772,Tectonin beta-propeller repeat-containing protein 2;IPR036322,WD40-repeat-containing domain superfamily;IPR009091,Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR006624,Beta-propeller repeat TECPR;IPR001680,WD40 repeat","KOG3621,WD40 repeat-containing protein;KOG3669,Uncharacterized conserved protein, contains dysferlin, TECPR and PH domains;ENOG4111FBT,-","-","-"]
["CPD",5.873974229,1.464183923,2.002210824,5.554739912,{"v":2.58e-12,"d":"2.58E-12"},{"v":4.21e-11,"d":"4.21E-11"},"ENSG00000108582","K7CU50,Carboxypeptidase D","XP_009430742.2,carboxypeptidase D","PF00246,Zinc carboxypeptidase;PF13620,Carboxypeptidase regulatory-like domain","IPR008969,Carboxypeptidase-like, regulatory domain superfamily;IPR033848,Carboxypeptidase D, carboxypeptidase-like domain 3;IPR015567,Peptidase M14B, caboxypeptidase D;IPR000834,Peptidase M14, carboxypeptidase A;IPR034224,Carboxypeptidase D,  carboxypeptidase-like domain 2;IPR034241,Carboxypeptidase D,  carboxypeptidase-like domain 1","ENOG410XX0H,-;KOG2649,Zinc carboxypeptidase","GO:0006508,biological_process,proteolysis;GO:0016021,cellular_component,integral component of membrane;GO:0004181,molecular_function,metallocarboxypeptidase activity;GO:0004180,molecular_function,carboxypeptidase activity;GO:0008270,molecular_function,zinc ion binding;GO:0016020,cellular_component,membrane;GO:0004185,molecular_function,serine-type carboxypeptidase activity","-"]
["LGALS3",39.42809254,9.84220611,2.000592263,5.90899675,{"v":1.76e-13,"d":"1.76E-13"},{"v":3.8E-12,"d":"3.80E-12"},"ENSG00000131981","A0A024R693,Galectin","NP_002297.2,galectin-3 isoform 1","PF00337,alactoside-binding lectin","IPR001079,Galectin, carbohydrate recognition domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR015534,Galectin-3","ENOG4111EA0,-;KOG3587,Galectin, galactose-binding lectin","GO:0030246,molecular_function,carbohydrate binding","-"]
["CCDC7",0.76296021,0.185785359,2.000567118,1.685248124,0.025042572,0.042691749,"ENSG00000216937","H2RCE0,Uncharacterized protein","XP_009456503.1,coiled-coil domain-containing protein 7 isoform X30","PF15368,Spermatogenesis family BioT2","IPR029272,Coiled-coil domain-containing protein 7","ENOG411157R,-;ENOG410II8P,-","-","-"]
["CTD-2033D15.3",7.674567433,1.868802919,2.000567118,1.685248124,0.025042572,0.042691749,"ENSG00000278621","H2NMT2,Thrombospondin 1","XP_002825327.1,thrombospondin-1","PF00093,von Willebrand factor type C domain;PF00090,Thrombospondin type 1 domain;PF02412,Thrombospondin type 3 repeat;PF05735,Thrombospondin C-terminal region","IPR028499,Thrombospondin-1;IPR008859,Thrombospondin, C-terminal;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR028974,TSP type-3 repeat;IPR003367,Thrombospondin, type 3-like repeat;IPR001791,Laminin G domain;IPR017897,Thrombospondin, type 3 repeat;IPR001881,EGF-like calcium-binding domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR037349,Thrombospondin;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR001007,VWFC domain;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","ENOG410IFQQ,-;ENOG410XQKE,-","GO:0000187,biological_process,activation of MAPK activity;GO:0030169,molecular_function,low-density lipoprotein particle binding;GO:0010757,biological_process,negative regulation of plasminogen activation;GO:2000379,biological_process,positive regulation of reactive oxygen species metabolic process;GO:0001937,biological_process,negative regulation of endothelial cell proliferation;GO:0043236,molecular_function,laminin binding;GO:0030511,biological_process,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0051592,biological_process,response to calcium ion;GO:0005509,molecular_function,calcium ion binding;GO:0051918,biological_process,negative regulation of fibrinolysis;GO:0048661,biological_process,positive regulation of smooth muscle cell proliferation;GO:0090051,biological_process,negative regulation of cell migration involved in sprouting angiogenesis;GO:0050840,molecular_function,extracellular matrix binding;GO:0010754,biological_process,negative regulation of cGMP-mediated signaling;GO:0043537,biological_process,negative regulation of blood vessel endothelial cell migration;GO:0042327,biological_process,positive regulation of phosphorylation;GO:0032695,biological_process,negative regulation of interleukin-12 production;GO:0009749,biological_process,response to glucose;GO:0005576,cellular_component,extracellular region;GO:1903588,biological_process,negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0005577,cellular_component,fibrinogen complex;GO:0009986,cellular_component,cell surface;GO:0051897,biological_process,positive regulation of protein kinase B signaling;GO:0007155,biological_process,cell adhesion;GO:0043032,biological_process,positive regulation of macrophage activation;GO:0031091,cellular_component,platelet alpha granule;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0050921,biological_process,positive regulation of chemotaxis;GO:0031012,cellular_component,extracellular matrix;GO:0017134,molecular_function,fibroblast growth factor binding;GO:0006955,biological_process,immune response;GO:0001968,molecular_function,fibronectin binding;GO:0030198,biological_process,extracellular matrix organization;GO:2001027,biological_process,negative regulation of endothelial cell chemotaxis;GO:0043652,biological_process,engulfment of apoptotic cell;GO:0008201,molecular_function,heparin binding;GO:0032026,biological_process,response to magnesium ion;GO:0005615,cellular_component,extracellular space;GO:0030141,cellular_component,secretory granule;GO:0042493,biological_process,response to drug;GO:0030335,biological_process,positive regulation of cell migration;GO:0040037,biological_process,negative regulation of fibroblast growth factor receptor signaling pathway;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0002581,biological_process,negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0002544,biological_process,chronic inflammatory response;GO:0009897,cellular_component,external side of plasma membrane;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0010763,biological_process,positive regulation of fibroblast migration;GO:0010748,biological_process,negative regulation of plasma membrane long-chain fatty acid transport;GO:0001786,molecular_function,phosphatidylserine binding;GO:0002040,biological_process,sprouting angiogenesis;GO:0030194,biological_process,positive regulation of blood coagulation;GO:2000353,biological_process,positive regulation of endothelial cell apoptotic process;GO:1902043,biological_process,positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0070052,molecular_function,collagen V binding;GO:0010596,biological_process,negative regulation of endothelial cell migration;GO:0030823,biological_process,regulation of cGMP metabolic process;GO:0006954,biological_process,inflammatory response;GO:0070051,molecular_function,fibrinogen binding;GO:0007050,biological_process,cell cycle arrest;GO:0010595,biological_process,positive regulation of endothelial cell migration;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0001953,biological_process,negative regulation of cell-matrix adhesion;GO:0010751,biological_process,negative regulation of nitric oxide mediated signal transduction;GO:0043536,biological_process,positive regulation of blood vessel endothelial cell migration;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0005178,molecular_function,integrin binding;GO:0018149,biological_process,peptide cross-linking;GO:0042535,biological_process,positive regulation of tumor necrosis factor biosynthetic process;GO:0002605,biological_process,negative regulation of dendritic cell antigen processing and presentation;GO:0045727,biological_process,positive regulation of translation;GO:0016477,biological_process,cell migration","K16857,ko04115,p53 signaling pathway;K16857,ko04015,Rap1 signaling pathway;K16857,ko05219,Bladder cancer;K16857,ko04510,Focal adhesion;K16857,ko05206,MicroRNAs in cancer;K16857,ko04512,ECM-receptor interaction;K16857,ko05205,Proteoglycans in cancer;K16857,ko04151,PI3K-Akt signaling pathway;K16857,ko05144,Malaria;K16857,ko04145,Phagosome;K16857,ko04350,TGF-beta signaling pathway"]
["SRCIN1",0.346270584,0.084318951,2.000567118,1.685248124,0.025042572,0.042691749,"ENSG00000277363","A0A087X165,SRC kinase-signaling inhibitor 1","-","PF03915,Actin interacting protein 3","IPR026727,SRC kinase signalling inhibitor 1;IPR022782,Actin interacting protein 3-like, C-terminal","ENOG410XTBA,-;ENOG410IHFG,-","GO:0030334,biological_process,regulation of cell migration;GO:0034446,biological_process,substrate adhesion-dependent cell spreading;GO:0061001,biological_process,regulation of dendritic spine morphogenesis","-"]
["WIPI1",1.186602725,0.288944837,2.000567118,1.685248124,0.025042572,0.042691749,"ENSG00000070540","H2QDR0,WD repeat domain, phosphoinositide interacting 1","XP_001165276.1,WD repeat domain phosphoinositide-interacting protein 1 isoform X1","-","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR032909,WD repeat domain phosphoinositide-interacting protein 1","ENOG410XP6Y,-;KOG2110,Uncharacterized conserved protein, contains WD40 repeats","GO:0000422,biological_process,autophagy of mitochondrion;GO:0034045,cellular_component,phagophore assembly site membrane;GO:0050681,molecular_function,androgen receptor binding;GO:0000407,cellular_component,phagophore assembly site;GO:0030331,molecular_function,estrogen receptor binding;GO:0005737,cellular_component,cytoplasm;GO:0048203,biological_process,vesicle targeting, trans-Golgi to endosome;GO:0006914,biological_process,autophagy;GO:0005102,molecular_function,signaling receptor binding;GO:0005802,cellular_component,trans-Golgi network;GO:0034497,biological_process,protein localization to phagophore assembly site;GO:0006497,biological_process,protein lipidation;GO:0080025,molecular_function,phosphatidylinositol-3,5-bisphosphate binding;GO:0032266,molecular_function,phosphatidylinositol-3-phosphate binding;GO:0019898,cellular_component,extrinsic component of membrane;GO:0044804,biological_process,autophagy of nucleus;GO:0005829,cellular_component,cytosol;GO:0010008,cellular_component,endosome membrane;GO:0000421,cellular_component,autophagosome membrane","-"]
["CTB-33G10.11",11.21339575,2.730528709,2.000567118,1.685248124,0.025042572,0.042691749,"-","-","-","-","-","-","-","-"]
["SCUBE3",0.548779564,0.133631095,2.000567118,1.685248124,0.025042572,0.042691749,"ENSG00000146197","K7C6I2,Signal peptide, CUB domain, EGF-like 3","XP_016810785.1,-","PF12662,Complement Clr-like EGF-like;PF07699,Putative ephrin-receptor like;PF00431,CUB domain;PF14670,Coagulation Factor Xa inhibitory site;PF12947,domain;PF07645,Calcium-binding EGF domain","IPR024731,EGF domain;IPR035914,Spermadhesin, CUB domain superfamily;IPR018097,EGF-like calcium-binding, conserved site;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR001881,EGF-like calcium-binding domain;IPR000859,CUB domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR011641,Tyrosine-protein kinase ephrin type A/B receptor-like;IPR026823,Complement Clr-like EGF domain","ENOG410XP6K,-;KOG1217,Fibrillins and related proteins containing Ca2+-binding EGF-like domains","GO:0009986,cellular_component,cell surface;GO:0051291,biological_process,protein heterooligomerization;GO:0005509,molecular_function,calcium ion binding;GO:0051260,biological_process,protein homooligomerization;GO:0045880,biological_process,positive regulation of smoothened signaling pathway;GO:0005886,cellular_component,plasma membrane","-"]
["CLCN4",0.594612236,0.144791624,2.000567118,1.685248124,0.025042572,0.042691749,"ENSG00000073464","F7BX81,Chloride channel protein","XP_008987182.1,-","PF00571,CBS domain;PF00654,Voltage gated chloride channel","IPR014743,Chloride channel, core;IPR002246,Chloride channel ClC-4;IPR001807,Chloride channel, voltage gated;IPR000644,CBS domain","KOG0475,Cl- channel CLC-3 and related proteins (CLC superfamily);COG0038,Chloride channel protein EriC","GO:1902476,biological_process,chloride transmembrane transport;GO:0006821,biological_process,chloride transport;GO:0055085,biological_process,transmembrane transport;GO:0005247,molecular_function,voltage-gated chloride channel activity;GO:0006811,biological_process,ion transport;GO:0005254,molecular_function,chloride channel activity;GO:0015297,molecular_function,antiporter activity;GO:0016020,cellular_component,membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["PALB2",9.404362189,2.346862678,1.999258054,4.851988897,5.99E-10,{"v":5.84e-09,"d":"5.84E-09"},"ENSG00000083093","H2QAS1,Partner and localizer of BRCA2","XP_510877.2,partner and localizer of BRCA2 isoform X1","PF16756,Partner and localizer of BRCA2 WD40 domain","IPR031920,Partner and localiser of BRCA2, WD40 domain;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR036322,WD40-repeat-containing domain superfamily","ENOG410IIBP,-;ENOG4111F80,-","GO:0001833,biological_process,inner cell mass cell proliferation;GO:0007498,biological_process,mesoderm development;GO:0003677,molecular_function,DNA binding;GO:0036342,biological_process,post-anal tail morphogenesis;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0001756,biological_process,somitogenesis;GO:0035264,biological_process,multicellular organism growth;GO:0048568,biological_process,embryonic organ development;GO:0001701,biological_process,in utero embryonic development;GO:0009887,biological_process,animal organ morphogenesis;GO:0000724,biological_process,double-strand break repair via homologous recombination;GO:0005654,cellular_component,nucleoplasm","-"]
["C1orf159",1.0517058,0.259145401,1.99835046,2.295232344,0.00285251,0.006181719,"ENSG00000131591","G3RE52,Chromosome 1 open reading frame 159","-","PF14946,omain of unknown function (DUF4501)","IPR027888,Protein of unknown function DUF4501","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF600",1.424048847,0.350892531,1.99835046,2.295232344,0.00285251,0.006181719,"ENSG00000189190","H2QH20,Zinc finger protein 600","XP_016789794.1,zinc finger protein 600 isoform X2","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity","-"]
["LARGE1",0.622146914,0.153300012,1.99835046,2.295232344,0.00285251,0.006181719,"ENSG00000133424","H2QZS2,LARGE xylosyl- and glucuronyltransferase 1","XP_001154669.1,-;XP_016794553.1,-;XP_016794552.1,-;XP_016794554.1,-","PF13896,lycosyl-transferase for dystroglycan;PF01501,lycosyl transferase family 8","IPR029044,Nucleotide-diphospho-sugar transferases;IPR002495,Glycosyl transferase, family 8","ENOG410XRNY,-;KOG3765,Predicted glycosyltransferase","GO:0005794,cellular_component,Golgi apparatus;GO:0035269,biological_process,protein O-linked mannosylation;GO:0042285,molecular_function,xylosyltransferase activity;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0030145,molecular_function,manganese ion binding;GO:0015020,molecular_function,glucuronosyltransferase activity","-"]
["PLCXD2",0.740905289,0.18256265,1.99835046,2.295232344,0.00285251,0.006181719,"ENSG00000240891","A0A1B0GW80,PI-PLC X domain-containing protein 2","-","-","IPR000909,Phosphatidylinositol-specific phospholipase C, X domain;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily","-","GO:0006629,biological_process,lipid metabolic process;GO:0008081,molecular_function,phosphoric diester hydrolase activity","-"]
["MOSPD1",2.485564138,0.612455038,1.99835046,2.295232344,0.00285251,0.006181719,"ENSG00000101928","G3QMM4,Motile sperm domain containing 1","XP_004064943.1,-","PF00635,MSP (Major sperm protein) domain","IPR008962,PapD-like superfamily;IPR013783,Immunoglobulin-like fold;IPR000535,Major sperm protein (MSP) domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["C5orf17",4.667815356,1.156070623,1.997380666,2.719145133,0.000608709,1.543885E-3,"ENSG00000248874","Q8WYX4,Uncharacterized protein pp11662","-","-","-","-","-","-"]
["ZBTB26",1.99374503,0.493787754,1.997380666,2.719145133,0.000608709,1.543885E-3,"ENSG00000171448","H2QXU9,Zinc finger and BTB domain containing 26","XP_016817098.1,-;XP_009455523.1,-;XP_520241.3,-","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0042802,molecular_function,identical protein binding","-"]
["FERMT2",1.395182992,0.346530083,1.996836633,3.044606519,2.16503E-4,0.000608167,"ENSG00000073712","H2Q8B8,Fermitin family member 2","XP_003314374.1,-","PF00373,RM central domain;PF00169,PH domain","IPR019748,FERM central domain;IPR037837,Kindlin/fermitin, PH domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR037843,Kindlin/fermitin","KOG3727,Mitogen inducible gene product (contains ERM and PH domains);ENOG410XS1B,-","GO:0007229,biological_process,integrin-mediated signaling pathway","-"]
["2020-03-08",2.614297925,0.651936819,1.996068584,3.724260322,{"v":2.51e-06,"d":"2.51E-06"},{"v":1.09e-05,"d":"1.09E-05"},"ENSG00000165406","F6YPJ3,Membrane associated ring-CH-type finger 8","XP_015002409.1,-;XP_015002410.1,-;XP_015002408.1,-;XP_001102718.2,E3 ubiquitin-protein ligase MARCH8 isoform X1;XP_015002407.1,-","PF12906,RING-variant domain","IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011016,Zinc finger, RING-CH-type;IPR033275,E3 ubiquitin-protein ligase MARCH-like","KOG1609,Protein involved in mRNA turnover and stability;COG5183,Protein involved in mRNA turnover and stability","GO:0000209,biological_process,protein polyubiquitination;GO:0005764,cellular_component,lysosome;GO:0005768,cellular_component,endosome;GO:0046872,molecular_function,metal ion binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016020,cellular_component,membrane;GO:0008270,molecular_function,zinc ion binding;GO:0016021,cellular_component,integral component of membrane","-"]
["PKD2",4.059886078,1.013146338,1.995932264,3.893820705,{"v":5.15e-07,"d":"5.15E-07"},{"v":2.59e-06,"d":"2.59E-06"},"ENSG00000118762","K7B7C7,Polycystic kidney disease 2","XP_016807339.1,polycystin-2","PF08016,Polycystin cation channel","IPR002048,EF-hand domain;IPR013122,Polycystin cation channel, PKD1/PKD2;IPR027359,Voltage-dependent channel domain superfamily;IPR011992,EF-hand domain pair;IPR003915,Polycystic kidney disease type 2 protein","ENOG410XTGE,-;KOG3599,Ca2+-modulated nonselective cation channel polycystin","GO:2000134,biological_process,negative regulation of G1/S transition of mitotic cell cycle;GO:0005886,cellular_component,plasma membrane;GO:0048763,molecular_function,calcium-induced calcium release activity;GO:0072001,biological_process,renal system development;GO:0072214,biological_process,metanephric cortex development;GO:0030027,cellular_component,lamellipodium;GO:0021510,biological_process,spinal cord development;GO:0036064,cellular_component,ciliary basal body;GO:0051117,molecular_function,ATPase binding;GO:0001822,biological_process,kidney development;GO:0006816,biological_process,calcium ion transport;GO:0061333,biological_process,renal tubule morphogenesis;GO:0001947,biological_process,heart looping;GO:0071470,biological_process,cellular response to osmotic stress;GO:0015267,molecular_function,channel activity;GO:0071498,biological_process,cellular response to fluid shear stress;GO:0005245,molecular_function,voltage-gated calcium channel activity;GO:0044325,molecular_function,ion channel binding;GO:0007050,biological_process,cell cycle arrest;GO:0042805,molecular_function,actinin binding;GO:0031587,biological_process,positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0071320,biological_process,cellular response to cAMP;GO:0015271,molecular_function,outward rectifier potassium channel activity;GO:0005102,molecular_function,signaling receptor binding;GO:0005783,cellular_component,endoplasmic reticulum;GO:0060674,biological_process,placenta blood vessel development;GO:0071556,cellular_component,integral component of lumenal side of endoplasmic reticulum membrane;GO:0072164,biological_process,mesonephric tubule development;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0072218,biological_process,metanephric ascending thin limb development;GO:0007259,biological_process,JAK-STAT cascade;GO:0051209,biological_process,release of sequestered calcium ion into cytosol;GO:0072075,biological_process,metanephric mesenchyme development;GO:0050982,biological_process,detection of mechanical stimulus;GO:0072177,biological_process,mesonephric duct development;GO:0071158,biological_process,positive regulation of cell cycle arrest;GO:0010628,biological_process,positive regulation of gene expression;GO:0009925,cellular_component,basal plasma membrane;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0072208,biological_process,metanephric smooth muscle tissue development;GO:0061441,biological_process,renal artery morphogenesis;GO:0021915,biological_process,neural tube development;GO:0071458,cellular_component,integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0007368,biological_process,determination of left/right symmetry;GO:0005262,molecular_function,calcium channel activity;GO:0001889,biological_process,liver development;GO:0031514,cellular_component,motile cilium;GO:0060170,cellular_component,ciliary membrane;GO:0035904,biological_process,aorta development;GO:0005248,molecular_function,voltage-gated sodium channel activity;GO:0043398,molecular_function,HLH domain binding;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0042803,molecular_function,protein homodimerization activity;GO:0045180,cellular_component,basal cortex;GO:0071910,biological_process,determination of liver left/right asymmetry;GO:0022843,molecular_function,voltage-gated cation channel activity;GO:0016021,cellular_component,integral component of membrane;GO:0042127,biological_process,regulation of cell proliferation;GO:0030814,biological_process,regulation of cAMP metabolic process;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0031659,biological_process,positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0072284,biological_process,metanephric S-shaped body morphogenesis;GO:0035502,biological_process,metanephric part of ureteric bud development;GO:0072686,cellular_component,mitotic spindle;GO:0045429,biological_process,positive regulation of nitric oxide biosynthetic process;GO:0072235,biological_process,metanephric distal tubule development;GO:0090279,biological_process,regulation of calcium ion import;GO:0005929,cellular_component,cilium;GO:0051289,biological_process,protein homotetramerization;GO:0035725,biological_process,sodium ion transmembrane transport;GO:0003127,biological_process,detection of nodal flow;GO:0051219,molecular_function,phosphoprotein binding;GO:0072219,biological_process,metanephric cortical collecting duct development;GO:0031941,cellular_component,filamentous actin;GO:0005267,molecular_function,potassium channel activity;GO:0097730,cellular_component,non-motile cilium;GO:0005509,molecular_function,calcium ion binding;GO:0060315,biological_process,negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0007507,biological_process,heart development;GO:0005737,cellular_component,cytoplasm;GO:0005249,molecular_function,voltage-gated potassium channel activity;GO:0001658,biological_process,branching involved in ureteric bud morphogenesis;GO:0042802,molecular_function,identical protein binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0002133,cellular_component,polycystin complex;GO:0016020,cellular_component,membrane;GO:0070588,biological_process,calcium ion transmembrane transport;GO:0005911,cellular_component,cell-cell junction;GO:0071277,biological_process,cellular response to calcium ion;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0042994,biological_process,cytoplasmic sequestering of transcription factor;GO:0001892,biological_process,embryonic placenta development;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0071464,biological_process,cellular response to hydrostatic pressure","-"]
["GTF2A2",9.412433973,2.352140835,1.995664865,4.307315032,{"v":4.69e-08,"d":"4.69E-08"},{"v":2.97e-07,"d":"2.97E-07"},"ENSG00000140307","G3RVY6,Transcription initiation factor IIA subunit 2","XP_018866446.1,-;XP_004056327.1,-;XP_004056328.1,-;XP_004056329.1,-","PF02268,Transcription initiation factor IIA, gamma subunit, helical domain;PF02751,Transcription initiation factor IIA, gamma subunit","IPR009083,Transcription factor IIA, helical;IPR015871,Transcription initiation factor IIA, gamma subunit, C-terminal;IPR015872,Transcription initiation factor IIA, gamma subunit, N-terminal;IPR003194,Transcription initiation factor IIA, gamma subunit;IPR009088,Transcription factor IIA, beta-barrel","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030054,cellular_component,cell junction;GO:0051123,biological_process,RNA polymerase II transcriptional preinitiation complex assembly;GO:0042803,molecular_function,protein homodimerization activity;GO:0003713,molecular_function,transcription coactivator activity;GO:0005672,cellular_component,transcription factor TFIIA complex;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0051091,biological_process,positive regulation of DNA binding transcription factor activity;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0046982,molecular_function,protein heterodimerization activity;GO:0006367,biological_process,transcription initiation from RNA polymerase II promoter;GO:0017025,molecular_function,TBP-class protein binding;GO:0005634,cellular_component,nucleus;GO:0005669,cellular_component,transcription factor TFIID complex;GO:0005654,cellular_component,nucleoplasm","K03123,ko03022,Basal transcription factors;K03123,ko05203,Viral carcinogenesis"]
["PER2",4.765086527,1.191156918,1.995604129,4.422260795,{"v":1.71e-08,"d":"1.71E-08"},{"v":1.2e-07,"d":"1.20E-07"},"ENSG00000132326","K7CE70,Period homolog 2","XP_016806318.1,period circadian protein homolog 2 isoform X2","PF08447,PAS fold;PF12114,Period protein 2/3C-terminal region","IPR000014,PAS domain;IPR035965,PAS domain superfamily;IPR013655,PAS fold-3;IPR022728,Period circadian-like, C-terminal","ENOG410Y118,-;KOG3753,Circadian clock protein period","GO:0005634,cellular_component,nucleus","-"]
["FBXO28",21.37298462,5.367088197,1.992431232,6.355046682,{"v":8.59e-15,"d":"8.59E-15"},{"v":2.51e-13,"d":"2.51E-13"},"ENSG00000143756","H2Q173,F-box protein 28","XP_001135277.1,-","PF00646,-box domain","IPR036047,F-box-like domain superfamily;IPR001810,F-box domain","ENOG410IJHM,-;ENOG410YPFN,-","GO:0000776,cellular_component,kinetochore","-"]
["ISG20L2",22.0672769,5.542008098,1.992153648,6.203299182,2.34E-14,{"v":6.09e-13,"d":"6.09E-13"},"ENSG00000143319","H2Q0A3,Interferon stimulated exonuclease gene 20kDa-like 2","XP_009432828.1,-;XP_009432810.1,interferon-stimulated 20 kDa exonuclease-like 2;XP_009432816.1,-;XP_009432824.1,-","PF00929,xonuclease","IPR036397,Ribonuclease H superfamily;IPR013520,Exonuclease, RNase T/DNA polymerase III;IPR037433,ISG20, DEDDh 3'-5' exonuclease domain;IPR034933,Interferon-stimulated 20kDa exonuclease-like 2;IPR012337,Ribonuclease H-like superfamily","KOG2249,3'-5' exonuclease;COG0847,DNA polymerase III, epsilon subunit and related 3'-5' exonucleases","GO:0003676,molecular_function,nucleic acid binding;GO:0090503,biological_process,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0000175,molecular_function,3'-5'-exoribonuclease activity;GO:0004527,molecular_function,exonuclease activity","-"]
["ZMYM3",5.665257948,1.421327842,1.991126219,4.671368013,{"v":2.18e-09,"d":"2.18E-09"},{"v":1.86e-08,"d":"1.86E-08"},"ENSG00000147130","G7Q2Z9,Uncharacterized protein","-","PF06467,MYM-type Zinc finger with FCS sequence motif;PF12012,omain of unknown function (DUF3504)","IPR021893,Protein of unknown function DUF3504;IPR011017,TRASH domain;IPR010507,Zinc finger, MYM-type","-","GO:0008270,molecular_function,zinc ion binding","-"]
["ARNT",22.37577182,5.63202975,1.989198627,6.528296098,{"v":2.87e-15,"d":"2.87E-15"},9.36E-14,"ENSG00000143437","K7CRV0,Aryl hydrocarbon receptor nuclear translocator","-","PF14598,PAS domain;PF00010,Helix-loop-helix DNA-binding domain;PF00989,PAS fold","-","-","-","-"]
["DOCK9",3.077237304,0.774042966,1.987915339,4.883551588,{"v":4.52e-10,"d":"4.52E-10"},{"v":4.52e-09,"d":"4.52E-09"},"ENSG00000088387","A0A0A0MSY4,Dedicator of cytokinesis protein 9","-","PF06920,ock homology region 2;PF14429,C2 domain in Dock180 and Zizimin proteins;PF11878,omain of unknown function (DUF3398);PF00169,PH domain","IPR026796,Dedicator of cytokinesis 9;IPR037809,Dedicator of cytokinesis D, C2 domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR010703,Dedicator of cytokinesis, C-terminal;IPR035892,C2 domain superfamily;IPR016024,Armadillo-type fold;IPR021816,Dedicator of cytokinesis C/D, N-terminal;IPR027007,DHR-1 domain;IPR027357,DHR-2 domain;IPR026791,Dedicator of cytokinesis","ENOG410XNVY,-;KOG1997,PH domain-containing protein","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005622,cellular_component,intracellular","-"]
["SMARCAL1",3.590815237,0.900881428,1.98683086,3.624116017,{"v":5.77e-06,"d":"5.77E-06"},{"v":2.31e-05,"d":"2.31E-05"},"ENSG00000138375","H2R0H8,SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1","XP_001153124.1,-;XP_009442517.1,-;XP_009442518.1,-;XP_001153008.1,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 isoform X1","PF00271,Helicase conserved C-terminal domain;PF07443,HepA-related protein (HARP);PF00176,SNF2 family N-terminal domain","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR030101,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1;IPR010003,HARP domain;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR001650,Helicase, C-terminal","COG0553,Superfamily II DNA/RNA helicases, SNF2 family;KOG1000,Chromatin remodeling protein HARP/SMARCAL1, DEAD-box superfamily","GO:0036310,molecular_function,annealing helicase activity;GO:0000733,biological_process,DNA strand renaturation;GO:0035861,cellular_component,site of double-strand break;GO:0008094,molecular_function,DNA-dependent ATPase activity;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0006259,biological_process,DNA metabolic process;GO:0005524,molecular_function,ATP binding;GO:0031297,biological_process,replication fork processing;GO:0005662,cellular_component,DNA replication factor A complex;GO:0006281,biological_process,DNA repair;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["SDR39U1",5.057234459,1.268783911,1.985492939,3.416457113,{"v":1.68e-05,"d":"1.68E-05"},{"v":6.09e-05,"d":"6.09E-05"},"ENSG00000100445","G1S018,Short chain dehydrogenase/reductase family 39U member 1","XP_003260749.1,epimerase family protein SDR39U1 isoform X1","PF08338,omain of unknown function (DUF1731);PF01370,NAD dependent epimerase/dehydratase family","IPR001509,NAD-dependent epimerase/dehydratase;IPR036291,NAD(P)-binding domain superfamily;IPR013549,Domain of unknown function DUF1731;IPR010099,Epimerase family protein SDR39U1","KOG3019,Predicted nucleoside-diphosphate sugar epimerase;COG1090,Predicted nucleoside-diphosphate sugar epimerase","GO:0050662,molecular_function,coenzyme binding;GO:0003824,molecular_function,catalytic activity","-"]
["PCNX2",2.354834593,0.592948688,1.985122804,4.414104802,{"v":1.71e-08,"d":"1.71E-08"},{"v":1.2e-07,"d":"1.20E-07"},"ENSG00000135749","G3SKS1,Pecanex homolog 2","XP_004028655.2,pecanex-like protein 2 isoform X1","PF05041,Pecanex protein (C-terminus)","IPR007735,Pecanex","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NUP214",8.544347595,2.157330905,1.984406569,6.148417902,3.93E-14,{"v":9.85e-13,"d":"9.85E-13"},"ENSG00000126883","A0A024R8B6,Nucleoporin 214kDa, isoform CRA_b","-","-","IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR026054,Nuclear pore complex protein","ENOG410YBVS,-;KOG3630,Nuclear pore complex, Nup214/CAN component","-","-"]
["BACE2",1.357761513,0.340641902,1.983623336,3.173119905,{"v":7.98e-05,"d":"7.98E-05"},0.000246735,"ENSG00000182240","H2R1L7,Beta-site APP-cleaving enzyme 2","XP_001171642.1,beta-secretase 2","PF00026,ukaryotic aspartyl protease","IPR033121,Peptidase family A1 domain;IPR001461,Aspartic peptidase A1 family;IPR033874,Memapsin-like;IPR021109,Aspartic peptidase domain superfamily;IPR009121,Beta-secretase BACE2;IPR001969,Aspartic peptidase, active site;IPR009119,Beta-secretase BACE","KOG1339,Aspartyl protease;ENOG410XNV7,-","GO:0006508,biological_process,proteolysis;GO:0005794,cellular_component,Golgi apparatus;GO:0016787,molecular_function,hydrolase activity;GO:0004190,molecular_function,aspartic-type endopeptidase activity;GO:0030163,biological_process,protein catabolic process;GO:0016020,cellular_component,membrane;GO:0050435,biological_process,amyloid-beta metabolic process;GO:0006509,biological_process,membrane protein ectodomain proteolysis;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0042985,biological_process,negative regulation of amyloid precursor protein biosynthetic process;GO:0001540,molecular_function,amyloid-beta binding;GO:0008233,molecular_function,peptidase activity","K07747,ko05010,Alzheimer's disease"]
["MAP4K3",11.54619134,2.916404489,1.983059226,5.488327901,5.12E-12,{"v":7.81e-11,"d":"7.81E-11"},"ENSG00000011566","A8K602,Mitogen-activated protein kinase kinase kinase kinase","NP_003609.2,mitogen-activated protein kinase kinase kinase kinase 3 isoform 1","PF00069,Protein kinase domain;PF00780,CNH domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR021160,Mitogen-activated protein (MAP) kinase kinase kinase kinase;IPR001180,Citron homology (CNH) domain;IPR000719,Protein kinase domain","ENOG410XP9G,-;KOG0576,Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0000165,biological_process,MAPK cascade;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0000185,biological_process,activation of MAPKKK activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005622,cellular_component,intracellular;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0008349,molecular_function,MAP kinase kinase kinase kinase activity","K04406,ko04010,MAPK signaling pathway"]
["NUP153",22.56462077,5.705582377,1.982538757,6.431021435,{"v":7.07e-15,"d":"7.07E-15"},{"v":2.11e-13,"d":"2.11E-13"},"ENSG00000124789","A0A024QZW7,Nucleoporin 153kDa, isoform CRA_a","-","PF10599,Retro-transposon transporting motif;PF00641,Zn-finger in Ran binding protein and others;PF08604,Nucleoporin Nup153-like","IPR018892,Retro-transposon transporting motif;IPR036443,Zinc finger, RanBP2-type superfamily;IPR037625,Nuclear pore complex protein Nup153;IPR026054,Nuclear pore complex protein;IPR013913,Nucleoporin Nup153, N-terminal;IPR001876,Zinc finger, RanBP2-type","KOG4719,Nuclear pore complex protein;ENOG41107SV,-","GO:0017056,molecular_function,structural constituent of nuclear pore;GO:0006913,biological_process,nucleocytoplasmic transport;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["SCYL2",15.23604728,3.854348772,1.98164409,6.178913249,{"v":4.02e-14,"d":"4.02E-14"},{"v":1e-12,"d":"1.00E-12"},"ENSG00000136021","A0A0U1RQQ9,SCY1-like protein 2","NP_001317183.1,-;NP_001317182.1,SCY1-like protein 2 isoform 2","PF00069,Protein kinase domain","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","-","GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["ZNF354A",3.545383913,0.889483393,1.980826528,2.879092024,0.000296643,0.0008079,"ENSG00000169131","V9HWI2,Epididymis luminal protein 104","XP_016865280.1,-;NP_005640.2,zinc finger protein 354A isoform 1;NP_001311268.1,zinc finger protein 354A isoform 2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF16622,zinc-finger C2H2-type","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0005730,cellular_component,nucleolus;GO:0003676,molecular_function,nucleic acid binding;GO:0051593,biological_process,response to folic acid;GO:0007576,biological_process,nucleolar fragmentation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001666,biological_process,response to hypoxia;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular;GO:0005829,cellular_component,cytosol;GO:0001822,biological_process,kidney development;GO:0005634,cellular_component,nucleus","-"]
["GPR158",2.858373481,0.720978329,1.980526108,3.881952437,{"v":6.87e-07,"d":"6.87E-07"},{"v":3.36E-6,"d":"3.36E-06"},"ENSG00000151025","H2Q1R0,Uncharacterized protein","XP_521427.2,probable G-protein coupled receptor 158","PF00003,7 transmembrane sweet-taste receptor of 3 GCPR","IPR017978,GPCR family 3, C-terminal","ENOG410XXEC,-;KOG4418,Predicted membrane protein","GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0072659,biological_process,protein localization to plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["ZNF480",11.24449406,2.845712302,1.979666058,5.132192465,1.15E-10,{"v":1.29e-09,"d":"1.29E-09"},"ENSG00000198464","G1R284,Zinc finger protein 480","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","-","-","-","-"]
["CXCL16",6.969123806,1.759109405,1.97861183,3.710865735,{"v":3.38e-06,"d":"3.38E-06"},{"v":1.43E-5,"d":"1.43E-05"},"ENSG00000161921","G3QRU8,C-X-C motif chemokine ligand 16","-","-","IPR026296,CXC chemokine 16","-","GO:0030307,biological_process,positive regulation of cell growth;GO:0006898,biological_process,receptor-mediated endocytosis;GO:0005044,molecular_function,scavenger receptor activity;GO:0034097,biological_process,response to cytokine;GO:0034612,biological_process,response to tumor necrosis factor;GO:0034341,biological_process,response to interferon-gamma;GO:0005041,molecular_function,low-density lipoprotein particle receptor activity;GO:0008009,molecular_function,chemokine activity;GO:0006935,biological_process,chemotaxis;GO:0016020,cellular_component,membrane;GO:0048247,biological_process,lymphocyte chemotaxis;GO:0030335,biological_process,positive regulation of cell migration;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space","-"]
["KSR2",0.428347261,0.107465872,1.976185317,2.507247444,1.888542E-3,0.004291487,"ENSG00000171435","H2Q6Z2,Kinase suppressor of ras 2","XP_009424622.1,-","PF13543,SAM like domain present in kinase suppressor RAS 1;PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR025561,Kinase suppressor of RAS, SAM-like domain;IPR000719,Protein kinase domain","ENOG410Y4UP,-;KOG0193,Serine/threonine protein kinase RAF","GO:0007265,biological_process,Ras protein signal transduction;GO:0019722,biological_process,calcium-mediated signaling;GO:0035556,biological_process,intracellular signal transduction;GO:0046872,molecular_function,metal ion binding;GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0004871,molecular_function,signal transducer activity;GO:0005524,molecular_function,ATP binding;GO:0043410,biological_process,positive regulation of MAPK cascade","K18529,ko04013,MAPK signaling pathway - fly;K18529,ko04014,Ras signaling pathway"]
["ELOVL7",1.712452971,0.429628643,1.976185317,2.507247444,1.888542E-3,0.004291487,"ENSG00000164181","G1QQV3,Elongation of very long chain fatty acids protein 7","-","PF01151,NS1/SUR4 family","-","-","-","-"]
["FAM214A",2.632542294,0.666524502,1.976086395,4.100241804,{"v":2.49e-07,"d":"2.49E-07"},{"v":1.33E-6,"d":"1.33E-06"},"ENSG00000047346","H2RDA4,Uncharacterized protein","XP_009427430.2,-;XP_009427429.2,protein FAM214A isoform X2;XP_510417.4,-;XP_009427431.2,-;XP_009427432.2,-;XP_016783745.1,-","PF13889,Chromosome segregation during meiosis;PF13915,omain of unknown function (DUF4210)","IPR025261,Domain of unknown function DUF4210;IPR033473,Protein FAM214/SPAC3H8.04, C-terminal","ENOG41115V6,-;KOG2306,Uncharacterized conserved protein","-","-"]
["SECISBP2L",12.31113065,3.126343941,1.976053692,6.09136131,{"v":8.6E-14,"d":"8.60E-14"},1.98E-12,"ENSG00000138593","G3QWI4,SECIS binding protein 2 like","XP_004056206.1,-","PF01248,Ribosomal protein L7Ae/L30e/S12e/Gadd45 family","IPR029064,50S ribosomal protein L30e-like;IPR004038,Ribosomal protein L7Ae/L30e/S12e/Gadd45","-","-","-"]
["MKL1",4.891635831,1.240773421,1.974564775,4.405901148,{"v":2.17e-08,"d":"2.17E-08"},{"v":1.48E-7,"d":"1.48E-07"},"ENSG00000196588","W0Z7M9,MKL/myocardin-like protein 1","NP_001305068.1,MKL/myocardin-like protein 1 isoform 4","PF02037,SAP domain;PF02755,RPEL repeat","IPR036361,SAP domain superfamily;IPR004018,RPEL repeat;IPR029992,MKL/myocardin-like protein 1;IPR003034,SAP domain","ENOG410IFJX,-;ENOG41101AM,-","GO:0010735,biological_process,positive regulation of transcription via serum response element binding;GO:0030036,biological_process,actin cytoskeleton organization;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:2001234,biological_process,negative regulation of apoptotic signaling pathway;GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003713,molecular_function,transcription coactivator activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0003785,molecular_function,actin monomer binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0001764,biological_process,neuron migration;GO:0030900,biological_process,forebrain development;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0031175,biological_process,neuron projection development;GO:0005634,cellular_component,nucleus;GO:0003779,molecular_function,actin binding","-"]
["YTHDF2",14.70665321,3.7359916,1.974340315,5.193291451,{"v":5.98e-11,"d":"5.98E-11"},{"v":7.17e-10,"d":"7.17E-10"},"ENSG00000198492","A0A0D9S805,YTH N6-methyladenosine RNA binding protein 2","XP_007977941.1,-","PF04146,YT521-B-like domain","IPR007275,YTH domain","-","GO:0003723,molecular_function,RNA binding;GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0061157,biological_process,mRNA destabilization;GO:1903679,biological_process,positive regulation of cap-independent translational initiation;GO:0005737,cellular_component,cytoplasm;GO:0001556,biological_process,oocyte maturation;GO:1990247,molecular_function,N6-methyladenosine-containing RNA binding;GO:0005815,cellular_component,microtubule organizing center;GO:0000932,cellular_component,P-body;GO:1903538,biological_process,regulation of meiotic cell cycle process involved in oocyte maturation;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0043488,biological_process,regulation of mRNA stability","-"]
["LAMP2",18.64960243,4.743589505,1.97368241,6.037205908,{"v":1.08e-13,"d":"1.08E-13"},{"v":2.45e-12,"d":"2.45E-12"},"ENSG00000005893","G7Q3L7,Uncharacterized protein","XP_005594542.1,lysosome-associated membrane glycoprotein 2 isoform X1","PF01299,Lysosome-associated membrane glycoprotein (Lamp)","IPR018134,Lysosome-associated membrane glycoprotein, conserved site;IPR002000,Lysosome-associated membrane glycoprotein","-","GO:0031088,cellular_component,platelet dense granule membrane;GO:0005770,cellular_component,late endosome;GO:0044754,cellular_component,autolysosome;GO:0009267,biological_process,cellular response to starvation;GO:0005764,cellular_component,lysosome;GO:0005615,cellular_component,extracellular space;GO:0019904,molecular_function,protein domain specific binding;GO:0050821,biological_process,protein stabilization;GO:0030670,cellular_component,phagocytic vesicle membrane;GO:0031647,biological_process,regulation of protein stability;GO:0097352,biological_process,autophagosome maturation;GO:0016021,cellular_component,integral component of membrane;GO:0097637,cellular_component,integral component of autophagosome membrane;GO:0006605,biological_process,protein targeting;GO:1905146,biological_process,lysosomal protein catabolic process;GO:0061740,biological_process,protein targeting to lysosome involved in chaperone-mediated autophagy;GO:0016020,cellular_component,membrane;GO:0031902,cellular_component,late endosome membrane;GO:0005765,cellular_component,lysosomal membrane;GO:0019899,molecular_function,enzyme binding;GO:0070062,cellular_component,extracellular exosome;GO:0006914,biological_process,autophagy;GO:0061684,biological_process,chaperone-mediated autophagy;GO:0046716,biological_process,muscle cell cellular homeostasis","K06528,ko04142,Lysosome;K06528,ko04145,Phagosome;K06528,ko05152,Tuberculosis"]
["SOCS3",5.211268733,1.318324029,1.97269871,3.290954015,{"v":4.26e-05,"d":"4.26E-05"},0.000140649,"ENSG00000184557","A0A096N6K0,Suppressor of cytokine signaling 3","XP_009189620.1,-","PF07525,SOCS box;PF00017,SH2 domain","IPR028414,Suppressor of cytokine signalling 3;IPR001496,SOCS box domain;IPR036860,SH2 domain superfamily;IPR036036,SOCS box-like domain superfamily;IPR000980,SH2 domain;IPR035863,SOCS3, SH2 domain","-","GO:0016567,biological_process,protein ubiquitination;GO:0009968,biological_process,negative regulation of signal transduction;GO:0042532,biological_process,negative regulation of tyrosine phosphorylation of STAT protein;GO:0007259,biological_process,JAK-STAT cascade;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0046426,biological_process,negative regulation of JAK-STAT cascade;GO:0035556,biological_process,intracellular signal transduction;GO:0060674,biological_process,placenta blood vessel development;GO:0045595,biological_process,regulation of cell differentiation;GO:0060670,biological_process,branching involved in labyrinthine layer morphogenesis;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0005622,cellular_component,intracellular;GO:0046627,biological_process,negative regulation of insulin receptor signaling pathway;GO:0060708,biological_process,spongiotrophoblast differentiation;GO:0060707,biological_process,trophoblast giant cell differentiation;GO:0050728,biological_process,negative regulation of inflammatory response;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0045597,biological_process,positive regulation of cell differentiation","-"]
["PAPD7",6.264608107,1.593646822,1.971474934,4.788643542,{"v":1.5E-9,"d":"1.50E-09"},{"v":1.32e-08,"d":"1.32E-08"},"ENSG00000112941","A0A0X1KG68,Non-canonical poly","XP_005248291.1,non-canonical poly(A) RNA polymerase PAPD7 isoform X1","PF03828,Cid1 family poly A polymerase;PF01909,Nucleotidyltransferase domain","IPR002934,Polymerase, nucleotidyl transferase domain;IPR002058,PAP/25A-associated","-","GO:0031965,cellular_component,nuclear membrane;GO:0005794,cellular_component,Golgi apparatus;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0005654,cellular_component,nucleoplasm","-"]
["DOCK1",20.21123565,5.151181647,1.971300423,6.704650287,{"v":1.57e-15,"d":"1.57E-15"},{"v":5.47e-14,"d":"5.47E-14"},"ENSG00000150760","A0A096LNH6,Dedicator of cytokinesis protein 1","-","PF16172,OCK N-terminus;PF06920,ock homology region 2;PF14604,Variant SH3 domain;PF14429,C2 domain in Dock180 and Zizimin proteins","IPR010703,Dedicator of cytokinesis, C-terminal;IPR036028,SH3-like domain superfamily;IPR035892,C2 domain superfamily;IPR016024,Armadillo-type fold;IPR001452,SH3 domain;IPR026791,Dedicator of cytokinesis;IPR030717,Dedicator of cytokinesis protein 1;IPR027007,DHR-1 domain;IPR027357,DHR-2 domain;IPR032376,Dedicator of cytokinesis, N-terminal domain","KOG1998,Signaling protein DOCK180;ENOG410XQH7,-","GO:0007010,biological_process,cytoskeleton organization;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0065009,biological_process,regulation of molecular function;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0016607,cellular_component,nuclear speck;GO:0005096,molecular_function,GTPase activator activity;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0016477,biological_process,cell migration","-"]
["RPAP2",2.327225785,0.592554358,1.9699555,4.700431706,{"v":2.46e-09,"d":"2.46E-09"},{"v":2.07E-8,"d":"2.07E-08"},"ENSG00000122484","H2PZE4,Uncharacterized protein","XP_001153375.1,putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 isoform X1","PF04181,Rtr1/RPAP2 family","IPR007308,Rtr1/RPAP2 domain;IPR038534,Rtr1/RPAP2 domain superfamily","KOG4780,Uncharacterized conserved protein;ENOG410ZZZC,-","GO:0005730,cellular_component,nucleolus;GO:0005737,cellular_component,cytoplasm;GO:0070940,biological_process,dephosphorylation of RNA polymerase II C-terminal domain;GO:0009301,biological_process,snRNA transcription;GO:0016591,cellular_component,DNA-directed RNA polymerase II, holoenzyme;GO:0008420,molecular_function,CTD phosphatase activity;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["UBE4B",12.92919503,3.302479946,1.967785091,6.231176257,3.32E-14,{"v":8.42e-13,"d":"8.42E-13"},"ENSG00000130939","H2PXZ4,Uncharacterized protein","-","PF04564,U-box domain;PF10408,Ubiquitin elongating factor core","IPR003613,U box domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR019474,Ubiquitin conjugation factor E4, core","KOG2042,Ubiquitin fusion degradation protein-2;COG5113,Ubiquitin fusion degradation protein 2","GO:0019899,molecular_function,enzyme binding;GO:0000209,biological_process,protein polyubiquitination;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0044257,biological_process,cellular protein catabolic process;GO:0005634,cellular_component,nucleus;GO:0034450,molecular_function,ubiquitin-ubiquitin ligase activity;GO:0000151,cellular_component,ubiquitin ligase complex;GO:0009411,biological_process,response to UV;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0051865,biological_process,protein autoubiquitination;GO:0008626,biological_process,granzyme-mediated apoptotic signaling pathway;GO:0031175,biological_process,neuron projection development;GO:0006513,biological_process,protein monoubiquitination;GO:0005524,molecular_function,ATP binding;GO:0003222,biological_process,ventricular trabecula myocardium morphogenesis","-"]
["RP11-982M15.2",17.54984482,4.447920069,1.967775394,3.022778855,2.16503E-4,0.000608167,"-","-","-","-","-","-","-","-"]
["ARHGEF5",11.46894136,2.928583559,1.967289757,5.422727594,1.41E-11,{"v":1.97e-10,"d":"1.97E-10"},"ENSG00000050327","B9EGR7,Rho guanine nucleotide exchange factor","-","PF14604,Variant SH3 domain;PF00621,RhoGEF domain;PF15441,Rho guanine nucleotide exchange factor 5/35","IPR029212,Rho guanine nucleotide exchange factor 5/35, N-terminal;IPR001331,Guanine-nucleotide dissociation stimulator, CDC24, conserved site;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR035899,Dbl homology (DH) domain superfamily;IPR001452,SH3 domain;IPR000219,Dbl homology (DH) domain","COG5422,RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases;KOG3523,Putative guanine nucleotide exchange factor TIM","GO:0035556,biological_process,intracellular signal transduction;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005622,cellular_component,intracellular;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","-"]
["SGMS1-AS1",0.420621835,0.10552768,1.966977587,2.000351027,0.010113281,0.019245475,"ENSG00000226200","A0A096NPD3,SHQ1, H/ACA ribonucleoprotein assembly factor","XP_003894232.1,protein SHQ1 homolog isoform X1","PF04925,SHQ1 protein","IPR007052,CS domain;IPR008978,HSP20-like chaperone;IPR007009,SHQ1 protein","-","GO:2000233,biological_process,negative regulation of rRNA processing;GO:0005737,cellular_component,cytoplasm;GO:0022618,biological_process,ribonucleoprotein complex assembly;GO:1904874,biological_process,positive regulation of telomerase RNA localization to Cajal body;GO:0005829,cellular_component,cytosol;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0005654,cellular_component,nucleoplasm","-"]
["HCN2",1.532899999,0.384581508,1.966977587,2.000351027,0.010113281,0.019245475,"ENSG00000099822","H0WXB3,Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2","-","PF00027,Cyclic nucleotide-binding domain;PF00520,Ion transport protein;PF08412,Ion transport protein N-terminal","IPR014710,RmlC-like jelly roll fold;IPR018488,Cyclic nucleotide-binding, conserved site;IPR000595,Cyclic nucleotide-binding domain;IPR018490,Cyclic nucleotide-binding-like;IPR005821,Ion transport domain;IPR013621,Ion transport N-terminal;IPR003938,Potassium channel, voltage-dependent, EAG/ELK/ERG","ENOG410XPSE,-;KOG0498,K+-channel ERG and related proteins, contain PAS/PAC sensor domain","GO:0005267,molecular_function,potassium channel activity;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0005886,cellular_component,plasma membrane;GO:0098855,cellular_component,HCN channel complex;GO:0005222,molecular_function,intracellular cAMP activated cation channel activity;GO:0005248,molecular_function,voltage-gated sodium channel activity;GO:0042391,biological_process,regulation of membrane potential;GO:1990573,biological_process,potassium ion import across plasma membrane;GO:0035725,biological_process,sodium ion transmembrane transport;GO:0042802,molecular_function,identical protein binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0071321,biological_process,cellular response to cGMP;GO:0006811,biological_process,ion transport;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0016020,cellular_component,membrane;GO:0005216,molecular_function,ion channel activity;GO:0055085,biological_process,transmembrane transport;GO:0005249,molecular_function,voltage-gated potassium channel activity;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0098719,biological_process,sodium ion import across plasma membrane;GO:0006813,biological_process,potassium ion transport;GO:0071320,biological_process,cellular response to cAMP","-"]
["CDK16",14.74116475,3.766823786,1.966927049,5.940290547,{"v":2.55e-13,"d":"2.55E-13"},{"v":5.37e-12,"d":"5.37E-12"},"ENSG00000102225","A0A0D9RMH9,Cyclin dependent kinase 16","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0007283,biological_process,spermatogenesis;GO:0031175,biological_process,neuron projection development;GO:0006887,biological_process,exocytosis;GO:0005737,cellular_component,cytoplasm;GO:0030252,biological_process,growth hormone secretion;GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0061178,biological_process,regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0008021,cellular_component,synaptic vesicle;GO:0005829,cellular_component,cytosol;GO:0031234,cellular_component,extrinsic component of cytoplasmic side of plasma membrane;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["RP11-373L24.1",4.955762415,1.264222342,1.965740729,4.222970926,{"v":1.5e-07,"d":"1.50E-07"},{"v":8.45e-07,"d":"8.45E-07"},"ENSG00000267520","A0A146LM53,LINE-1 reverse transcriptase","-","PF03372,ndonuclease/Exonuclease/phosphatase family;PF00078,Reverse transcriptase (RNA-dependent DNA polymerase)","IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR005135,Endonuclease/exonuclease/phosphatase;IPR000477,Reverse transcriptase domain","-","GO:0003964,molecular_function,RNA-directed DNA polymerase activity;GO:0006278,biological_process,RNA-dependent DNA biosynthetic process","-"]
["HERPUD2",8.7054089,2.220762721,1.965740729,4.222970926,{"v":1.5e-07,"d":"1.50E-07"},{"v":8.45e-07,"d":"8.45E-07"},"ENSG00000122557","A0A024RA77,Uncharacterized protein","NP_071768.3,homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein;XP_016867995.1,-","PF00240,Ubiquitin family","IPR000626,Ubiquitin domain;IPR029071,Ubiquitin-like domain superfamily","ENOG410ZJAF,-;KOG4583,Membrane-associated ER protein involved in stress response (contains ubiquitin-like domain)","GO:0007283,biological_process,spermatogenesis;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TANC2",9.232138072,2.364404288,1.964505067,7.062233083,{"v":2.3e-16,"d":"2.30E-16"},{"v":9.34e-15,"d":"9.34E-15"},"ENSG00000170921","G3QEM9,Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2","-","PF12796,Ankyrin repeats (3 copies);PF13181,Tetratricopeptide repeat","IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR002110,Ankyrin repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain","-","-","-"]
["SLC35G1",2.260200534,0.575774102,1.963515271,3.399757365,{"v":2.32e-05,"d":"2.32E-05"},{"v":8.13e-05,"d":"8.13E-05"},"ENSG00000176273","H2Q2A5,Transmembrane protein 20","XP_521566.2,solute carrier family 35 member G1 isoform X1","PF00892,amA-like transporter family","IPR000620,EamA domain","COG0697,Permeases of the drug/metabolite transporter (DMT) superfamily;KOG4510,Permease of the drug/metabolite transporter (DMT) superfamily","GO:1990034,biological_process,calcium ion export across plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0051480,biological_process,regulation of cytosolic calcium ion concentration;GO:0016020,cellular_component,membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["CCDC74BP1",13.74435391,3.501301283,1.963515271,3.399757365,{"v":2.32e-05,"d":"2.32E-05"},{"v":8.13e-05,"d":"8.13E-05"},"ENSG00000250261","G3RUL8,Uncharacterized protein","-","-","-","-","-","-"]
["PLXDC2",8.238451766,2.11193913,1.962414742,6.045955851,1.37E-13,{"v":3.02e-12,"d":"3.02E-12"},"ENSG00000120594","G1RQC8,Plexin domain containing 2","XP_003257746.1,plexin domain-containing protein 2 isoform X1","PF01437,Plexin repeat","IPR016201,PSI domain;IPR031154,Plexin domain-containing protein 2;IPR031152,Plexin domain-containing protein;IPR002165,Plexin repeat","ENOG410Y7ZQ,-;KOG3848,Extracellular protein TEM7, contains PSI domain (tumor endothelial marker in humans)","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NCOA1",10.50732949,2.694787976,1.961566749,5.858363723,4.97E-13,{"v":9.64e-12,"d":"9.64E-12"},"ENSG00000084676","H2QHJ2,Nuclear receptor coactivator 1","XP_016803632.1,-;XP_016803637.1,-;XP_016803633.1,-;XP_016803636.1,-;XP_016803635.1,-;XP_016803634.1,-;XP_016803631.1,-","PF07469,omain of unknown function (DUF1518);PF14598,PAS domain;PF00989,PAS fold;PF08815,Nuclear receptor coactivator;PF00010,Helix-loop-helix DNA-binding domain;PF08832,Steroid receptor coactivator;PF16665,Unstructured region on nuclear receptor coactivator protein","IPR014920,Nuclear receptor coactivator, Ncoa-type, interlocking;IPR000014,PAS domain;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR009110,Nuclear receptor coactivator, interlocking;IPR028819,Nuclear receptor coactivator 1;IPR035965,PAS domain superfamily;IPR037077,Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR013767,PAS fold;IPR017426,Nuclear receptor coactivator;IPR014935,Nuclear receptor coactivator, receptor-binding domain;IPR010011,Domain of unknown function DUF1518","ENOG410XPF9,-;ENOG410IQ5S,-","GO:0043967,biological_process,histone H4 acetylation;GO:0032991,cellular_component,protein-containing complex;GO:0017162,molecular_function,aryl hydrocarbon receptor binding;GO:0046983,molecular_function,protein dimerization activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0000435,biological_process,positive regulation of transcription from RNA polymerase II promoter by galactose;GO:0005634,cellular_component,nucleus;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity;GO:0030331,molecular_function,estrogen receptor binding;GO:1904017,biological_process,cellular response to Thyroglobulin triiodothyronine;GO:2001038,biological_process,regulation of cellular response to drug;GO:0060713,biological_process,labyrinthine layer morphogenesis;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:2001141,biological_process,regulation of RNA biosynthetic process;GO:0047485,molecular_function,protein N-terminus binding;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0000790,cellular_component,nuclear chromatin;GO:0003682,molecular_function,chromatin binding;GO:0003677,molecular_function,DNA binding;GO:0002155,biological_process,regulation of thyroid hormone mediated signaling pathway;GO:0032870,biological_process,cellular response to hormone stimulus;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0016922,molecular_function,ligand-dependent nuclear receptor binding;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0019899,molecular_function,enzyme binding;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:0003713,molecular_function,transcription coactivator activity;GO:0035257,molecular_function,nuclear hormone receptor binding;GO:0005886,cellular_component,plasma membrane;GO:0043065,biological_process,positive regulation of apoptotic process","-"]
["ATG7",2.1775469,0.556430621,1.960941257,3.697340738,{"v":4.55e-06,"d":"4.55E-06"},{"v":1.87e-05,"d":"1.87E-05"},"ENSG00000197548","B3KQM6,cDNA FLJ90740 fis, clone PLACE1011045, highly similar to Autophagy-related protein 7","NP_006386.1,ubiquitin-like modifier-activating enzyme ATG7 isoform a","PF00899,ThiF family;PF16420,Ubiquitin-like modifier-activating enzyme ATG7 N-terminus","IPR035985,Ubiquitin-activating enzyme;IPR006285,Ubiquitin-like modifier-activating enzyme Atg7;IPR000594,THIF-type NAD/FAD binding fold;IPR032197,Ubiquitin-like modifier-activating enzyme Atg7, N-terminal","KOG2337,Ubiquitin activating E1 enzyme-like protein;COG0476,Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2","GO:0005737,cellular_component,cytoplasm;GO:0008641,molecular_function,ubiquitin-like modifier activating enzyme activity;GO:0006914,biological_process,autophagy","K08337,ko04140,Regulation of autophagy"]
["PPP1R3C",3.575073503,0.908733802,1.960046539,2.691512104,0.000883481,0.002151613,"ENSG00000119938","K7CP68,Protein phosphatase 1 regulatory subunit","XP_507911.2,protein phosphatase 1 regulatory subunit 3C","PF03370,Carbohydrate/starch-binding module (family 21)","IPR030683,Protein phosphatase 1 regulatory subunit 3C;IPR005036,CBM21 (carbohydrate binding type-21) domain;IPR017434,Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa;IPR038175,CBM21 domain superfamily","-","GO:0005975,biological_process,carbohydrate metabolic process;GO:0019888,molecular_function,protein phosphatase regulator activity;GO:0005978,biological_process,glycogen biosynthetic process;GO:0005977,biological_process,glycogen metabolic process;GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0019903,molecular_function,protein phosphatase binding","K07189,ko04931,Insulin resistance;K07189,ko04910,Insulin signaling pathway"]
["NUDT12",2.09653474,0.532909878,1.960046539,2.691512104,0.000883481,0.002151613,"ENSG00000112874","H2QRA4,Nudix","XP_009447713.1,-;XP_003310821.1,peroxisomal NADH pyrophosphatase NUDT12 isoform X2","PF12796,Ankyrin repeats (3 copies);PF09296,NADH pyrophosphatase-like rudimentary NUDIX domain;PF00293,NUDIX domain;PF09297,NADH pyrophosphatase zinc ribbon domain","IPR015797,NUDIX hydrolase-like domain superfamily;IPR015375,NADH pyrophosphatase-like, N-terminal;IPR002110,Ankyrin repeat;IPR020084,NUDIX hydrolase, conserved site;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR000086,NUDIX hydrolase domain;IPR015376,Zinc ribbon, NADH pyrophosphatase","KOG0504,FOG: Ankyrin repeat;KOG3084,NADH pyrophosphatase I of the Nudix family of hydrolases;COG2816,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding","GO:0016787,molecular_function,hydrolase activity;GO:0046872,molecular_function,metal ion binding","K03426,ko00760,Nicotinate and nicotinamide metabolism;K03426,ko04146,Peroxisome"]
["CDR2L",10.47618288,2.687285042,1.959015298,4.599275105,{"v":7.38e-09,"d":"7.38E-09"},{"v":5.59e-08,"d":"5.59E-08"},"ENSG00000109089","A0A024R8R6,Cerebellar degeneration-related protein 2-like, isoform CRA_b","NP_055418.2,cerebellar degeneration-related protein 2-like","-","IPR026079,Cerebellar degeneration-related protein 2","ENOG410XNUZ,-;ENOG410IDY5,-","-","-"]
["ATP1B1",9.059080492,2.323069665,1.957982878,4.153118581,{"v":1.61E-7,"d":"1.61E-07"},{"v":9.02E-7,"d":"9.02E-07"},"ENSG00000143153","A3KLL5,Sodium/potassium-transporting ATPase subunit beta","NP_001668.1,sodium/potassium-transporting ATPase subunit beta-1","PF00287,Sodium / potassium ATPase beta chain","IPR038702,Sodium/potassium-transporting ATPase subunit beta superfamily;IPR015565,Sodium/potassium-transporting ATPase subunit beta, chordates;IPR000402,Sodium/potassium-transporting ATPase subunit beta","KOG3927,Na+/K+ ATPase, beta subunit;ENOG411150A,-","GO:0019901,molecular_function,protein kinase binding;GO:0014704,cellular_component,intercalated disc;GO:0030001,biological_process,metal ion transport;GO:0005890,cellular_component,sodium:potassium-exchanging ATPase complex;GO:0001666,biological_process,response to hypoxia;GO:0055119,biological_process,relaxation of cardiac muscle;GO:0050821,biological_process,protein stabilization;GO:0042383,cellular_component,sarcolemma;GO:1903281,biological_process,positive regulation of calcium:sodium antiporter activity;GO:0016323,cellular_component,basolateral plasma membrane;GO:0005391,molecular_function,sodium:potassium-exchanging ATPase activity;GO:0016021,cellular_component,integral component of membrane;GO:0006814,biological_process,sodium ion transport;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0010882,biological_process,regulation of cardiac muscle contraction by calcium ion signaling;GO:0006811,biological_process,ion transport;GO:0008022,molecular_function,protein C-terminus binding;GO:0016020,cellular_component,membrane;GO:0010468,biological_process,regulation of gene expression;GO:0043209,cellular_component,myelin sheath;GO:0005901,cellular_component,caveola;GO:0016324,cellular_component,apical plasma membrane;GO:0005622,cellular_component,intracellular;GO:0010248,biological_process,establishment or maintenance of transmembrane electrochemical gradient;GO:0005886,cellular_component,plasma membrane;GO:0060048,biological_process,cardiac muscle contraction;GO:0006813,biological_process,potassium ion transport;GO:1903169,biological_process,regulation of calcium ion transmembrane transport","K01540,ko04971,Gastric acid secretion;K01540,ko04024,cAMP signaling pathway;K01540,ko04911,Insulin secretion;K01540,ko04919,Thyroid hormone signaling pathway;K01540,ko04978,Mineral absorption;K01540,ko04260,Cardiac muscle contraction;K01540,ko04974,Protein digestion and absorption;K01540,ko04961,Endocrine and other factor-regulated calcium reabsorption;K01540,ko04970,Salivary secretion;K01540,ko04973,Carbohydrate digestion and absorption;K01540,ko04960,Aldosterone-regulated sodium reabsorption;K01540,ko04976,Bile secretion;K01540,ko04972,Pancreatic secretion;K01540,ko04918,Thyroid hormone synthesis;K01540,ko04964,Proximal tubule bicarbonate reclamation;K01540,ko04261,Adrenergic signaling in cardiomyocytes;K01540,ko04022,cGMP-PKG signaling pathway"]
["ARV1",13.504276,3.462975514,1.957982878,4.153118581,{"v":1.61E-7,"d":"1.61E-07"},{"v":9.02E-7,"d":"9.02E-07"},"ENSG00000173409","H7C0E7,Protein ARV1","-","PF04161,Arv1-like family","IPR007290,Arv1 protein","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-484D2.5",28.88028794,7.379807322,1.957221349,3.153224118,1.11871E-4,0.000334822,"-","-","-","-","-","-","-","-"]
["SLC1A4",1.847938874,0.47220557,1.957221349,3.153224118,1.11871E-4,0.000334822,"ENSG00000115902","H2QHZ6,Amino acid transporter","XP_001166088.1,-","PF00375,Sodium:dicarboxylate symporter family","IPR001991,Sodium:dicarboxylate symporter;IPR018107,Sodium:dicarboxylate symporter, conserved site;IPR036458,Sodium:dicarboxylate symporter superfamily","KOG3787,Glutamate/aspartate and neutral amino acid transporters;COG1301,Na+/H+-dicarboxylate symporters","GO:1902476,biological_process,chloride transmembrane transport;GO:0050890,biological_process,cognition;GO:0015195,molecular_function,L-threonine transmembrane transporter activity;GO:0005815,cellular_component,microtubule organizing center;GO:0015825,biological_process,L-serine transport;GO:0015193,molecular_function,L-proline transmembrane transporter activity;GO:0015180,molecular_function,L-alanine transmembrane transporter activity;GO:0015811,biological_process,L-cystine transport;GO:0005813,cellular_component,centrosome;GO:0034589,biological_process,hydroxyproline transport;GO:0016021,cellular_component,integral component of membrane;GO:0015824,biological_process,proline transport;GO:0015194,molecular_function,L-serine transmembrane transporter activity;GO:0005254,molecular_function,chloride channel activity;GO:0016020,cellular_component,membrane;GO:0035524,biological_process,proline transmembrane transport;GO:0005882,cellular_component,intermediate filament;GO:0015175,molecular_function,neutral amino acid transmembrane transporter activity;GO:0015826,biological_process,threonine transport;GO:0055085,biological_process,transmembrane transport;GO:0015808,biological_process,L-alanine transport;GO:0015184,molecular_function,L-cystine transmembrane transporter activity;GO:0034590,molecular_function,L-hydroxyproline transmembrane transporter activity;GO:0015293,molecular_function,symporter activity","-"]
["PRKACB",7.762441599,1.996166604,1.956536949,5.080303773,2.54E-10,{"v":2.65e-09,"d":"2.65E-09"},"ENSG00000142875","H2R1G3,Protein kinase cAMP-activated catalytic subunit beta","XP_001137476.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0616,cAMP-dependent protein kinase catalytic subunit (PKA);ENOG410XPQQ,-","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0070613,biological_process,regulation of protein processing;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0045171,cellular_component,intercellular bridge;GO:0001843,biological_process,neural tube closure;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0097546,cellular_component,ciliary base;GO:0004691,molecular_function,cAMP-dependent protein kinase activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005813,cellular_component,centrosome;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:1901621,biological_process,negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0000287,molecular_function,magnesium ion binding","-"]
["ABCC2",16.53685864,4.258783545,1.95578386,6.040731271,1.54E-13,{"v":3.36e-12,"d":"3.36E-12"},"ENSG00000023839","H2NB99,ATP binding cassette subfamily C member 2","XP_002821105.1,canalicular multispecific organic anion transporter 1","PF00005,ABC transporter;PF00664,ABC transporter transmembrane region","IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR011527,ABC transporter type 1, transmembrane domain;IPR036640,ABC transporter type 1, transmembrane domain superfamily;IPR005292,Multi drug resistance-associated protein;IPR003593,AAA+ ATPase domain;IPR017871,ABC transporter, conserved site;IPR030247,Canalicular multispecific organic anion transporter 1","COG1132,ABC-type multidrug transport system, ATPase and permease components;KOG0054,Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily","GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0009986,cellular_component,cell surface;GO:0005887,cellular_component,integral component of plasma membrane;GO:0055085,biological_process,transmembrane transport;GO:0008514,molecular_function,organic anion transmembrane transporter activity;GO:0022857,molecular_function,transmembrane transporter activity;GO:0046581,cellular_component,intercellular canaliculus;GO:0005524,molecular_function,ATP binding;GO:0016324,cellular_component,apical plasma membrane;GO:0016887,molecular_function,ATPase activity;GO:0016020,cellular_component,membrane;GO:0000166,molecular_function,nucleotide binding;GO:0015711,biological_process,organic anion transport;GO:0016021,cellular_component,integral component of membrane","K05666,ko04976,Bile secretion;K05666,ko01524,Platinum drug resistance;K05666,ko02010,ABC transporters"]
["PCDHA12",3.047709969,0.781009312,1.955687325,3.500823356,{"v":9.41e-06,"d":"9.41E-06"},{"v":3.6e-05,"d":"3.60E-05"},"ENSG00000251664","H2R5A1,Protocadherin alpha-C2","-","PF08266,Cadherin-like;PF00028,Cadherin domain;PF15974,Cadherin C-terminal cytoplasmic tail, catenin-binding region","-","-","-","-"]
["ZNF280D",1.140423996,0.292769036,1.954723975,3.77988188,{"v":2.02e-06,"d":"2.02E-06"},{"v":8.94e-06,"d":"8.94E-06"},"ENSG00000137871","H2Q9H8,Zinc finger protein 280D","-","PF13836,omain of unknown function (DUF4195)","IPR013087,Zinc finger C2H2-type;IPR025243,Domain of unknown function DUF4195;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["FSTL1",5.686853485,1.464291779,1.954547087,5.008714241,{"v":3.79e-10,"d":"3.79E-10"},{"v":3.84E-9,"d":"3.84E-09"},"ENSG00000163430","A0A1D5Q5V4,Follistatin like 1","NP_001231516.1,-","-","IPR002350,Kazal domain;IPR015369,Follistatin/Osteonectin EGF domain;IPR003645,Follistatin-like, N-terminal;IPR002048,EF-hand domain;IPR036058,Kazal domain superfamily;IPR011992,EF-hand domain pair;IPR036773,TGF-beta binding (TB) domain superfamily","ENOG410IIPU,-;ENOG410ZJ7W,-","GO:0005509,molecular_function,calcium ion binding","-"]
["ABHD17C",7.725474812,1.987481608,1.953580889,4.213576914,{"v":1.93e-07,"d":"1.93E-07"},{"v":1.06E-6,"d":"1.06E-06"},"ENSG00000136379","F6SZE2,Abhydrolase domain containing 17C","-","PF12146,Serine aminopeptidase, S33;PF00326,Prolyl oligopeptidase family","IPR022742,Serine aminopeptidase, S33;IPR029058,Alpha/Beta hydrolase fold","COG1073,Hydrolases of the alpha/beta superfamily;KOG1552,Predicted alpha/beta hydrolase","GO:0008474,molecular_function,palmitoyl-(protein) hydrolase activity;GO:0098734,biological_process,macromolecule depalmitoylation;GO:0018345,biological_process,protein palmitoylation","-"]
["SLC39A11",5.018860316,1.291168868,1.953580889,4.213576914,{"v":1.93e-07,"d":"1.93E-07"},{"v":1.06E-6,"d":"1.06E-06"},"ENSG00000133195","H2QDR7,Solute carrier family 39","XP_001167322.1,zinc transporter ZIP11 isoform X1;XP_009431452.1,-;XP_009431453.1,-","PF02535,ZIP Zinc transporter","IPR003689,Zinc/iron permease","KOG2474,Zinc transporter and related ZIP domain-containing proteins;COG0428,Predicted divalent heavy-metal cations transporter","GO:0005794,cellular_component,Golgi apparatus;GO:0055085,biological_process,transmembrane transport;GO:0071577,biological_process,zinc ion transmembrane transport;GO:0005737,cellular_component,cytoplasm;GO:0030001,biological_process,metal ion transport;GO:0005886,cellular_component,plasma membrane;GO:0005385,molecular_function,zinc ion transmembrane transporter activity;GO:0016020,cellular_component,membrane;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane;GO:0046873,molecular_function,metal ion transmembrane transporter activity","-"]
["JMJD1C",14.10718107,3.644326227,1.951792377,6.63234486,{"v":4.24e-15,"d":"4.24E-15"},{"v":1.32e-13,"d":"1.32E-13"},"ENSG00000171988","H2Q1Y6,Jumonji domain containing 1C","XP_009456814.1,-;XP_001166726.1,probable JmjC domain-containing histone demethylation protein 2C isoform X1;XP_016773869.1,-","PF02373,JmjC domain, hydroxylase","IPR003347,JmjC domain","KOG1356,Putative transcription factor 5qNCA, contains JmjC domain;ENOG410XTAA,-","GO:0000785,cellular_component,chromatin;GO:0031490,molecular_function,chromatin DNA binding;GO:0033169,biological_process,histone H3-K9 demethylation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0032454,molecular_function,histone demethylase activity (H3-K9 specific);GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["ADGRF1",13.07840329,3.38205959,1.950335066,6.688073134,{"v":3.31e-15,"d":"3.31E-15"},1.06E-13,"ENSG00000153292","H2R782,Uncharacterized protein","-","PF00002,7 transmembrane receptor (Secretin family);PF01390,SEA domain;PF01825,PCR proteolysis site, GPS, motif","IPR000832,GPCR, family 2, secretin-like;IPR000203,GPS motif;IPR017981,GPCR, family 2-like;IPR008078,GPCR family 2, Ig-hepta-like receptor","ENOG410XSD2,-;KOG4193,G protein-coupled receptors","GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["NOTCH2",2.868627082,0.740967086,1.949926147,4.968769108,{"v":6E-10,"d":"6.00E-10"},{"v":5.84e-09,"d":"5.84E-09"},"ENSG00000134250","K7C726,Notch 2","-","PF00066,LNR domain;PF11936,omain of unknown function (DUF3454);PF12796,Ankyrin repeats (3 copies);PF00008,-like domain;PF06816,NOTCH protein;PF07684,NOTCH protein;PF12661,Human growth factor-like EGF;PF07645,Calcium-binding EGF domain","IPR024600,Domain of unknown function DUF3454, notch;IPR010660,Notch, NOD domain;IPR018097,EGF-like calcium-binding, conserved site;IPR000800,Notch domain;IPR022336,Neurogenic locus Notch 2;IPR011656,Notch, NODP domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR001881,EGF-like calcium-binding domain;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR035993,Notch-like domain superfamily;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR002110,Ankyrin repeat;IPR008297,Notch","-","GO:0030154,biological_process,cell differentiation;GO:0046872,molecular_function,metal ion binding;GO:0005509,molecular_function,calcium ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0050793,biological_process,regulation of developmental process;GO:0007219,biological_process,Notch signaling pathway;GO:0004872,-,-;GO:0016020,cellular_component,membrane;GO:0007275,biological_process,multicellular organism development;GO:0016021,cellular_component,integral component of membrane","-"]
["LATS2",7.960747072,2.055973571,1.949876398,4.853848866,{"v":1.25E-9,"d":"1.25E-09"},{"v":1.12e-08,"d":"1.12E-08"},"ENSG00000150457","A0A024RDM3,LATS, large tumor suppressor, homolog 2","NP_055387.2,serine/threonine-protein kinase LATS2;XP_005266399.1,-","PF00069,Protein kinase domain","IPR009060,UBA-like superfamily;IPR015940,Ubiquitin-associated domain;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XQC0,-;KOG0605,NDR and related serine/threonine kinases","GO:0016301,molecular_function,kinase activity;GO:0035329,biological_process,hippo signaling;GO:0016310,biological_process,phosphorylation;GO:0046620,biological_process,regulation of organ growth;GO:0000922,cellular_component,spindle pole;GO:0001827,biological_process,inner cell mass cell fate commitment;GO:0016740,molecular_function,transferase activity;GO:0030216,biological_process,keratinocyte differentiation;GO:0000082,biological_process,G1/S transition of mitotic cell cycle;GO:0001828,biological_process,inner cell mass cellular morphogenesis;GO:0005815,cellular_component,microtubule organizing center;GO:0004672,molecular_function,protein kinase activity;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:0034613,biological_process,cellular protein localization;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","K08791,ko04392,Hippo signaling pathway -multiple species;K08791,ko04391,Hippo signaling pathway - fly;K08791,ko04214,Apoptosis - fly;K08791,ko04390,Hippo signaling pathway"]
["FBXO27",8.968667683,2.313190576,1.949404869,4.079669162,{"v":3.25e-07,"d":"3.25E-07"},{"v":1.69e-06,"d":"1.69E-06"},"ENSG00000161243","G3QQ72,F-box protein 27","XP_004060748.1,-;XP_018869880.1,-","PF04300,-box associated region;PF00646,-box domain","IPR036047,F-box-like domain superfamily;IPR008979,Galactose-binding-like domain superfamily;IPR007397,F-box associated (FBA) domain;IPR001810,F-box domain","-","GO:0019005,cellular_component,SCF ubiquitin ligase complex","-"]
["ZBTB37",1.110196939,0.28618365,1.949211279,3.857908102,{"v":1.22E-6,"d":"1.22E-06"},{"v":5.67e-06,"d":"5.67E-06"},"ENSG00000185278","H2R8E6,Uncharacterized protein","XP_009436790.1,-;XP_009436798.1,-;XP_514007.2,-;XP_016788374.1,-;XP_009436803.1,-","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["HEG1",10.33579675,2.674129879,1.949122359,6.035487501,1.95E-13,{"v":4.17e-12,"d":"4.17E-12"},"ENSG00000173706","H2QN94,Uncharacterized protein","-","PF00008,-like domain;PF07645,Calcium-binding EGF domain","IPR018097,EGF-like calcium-binding, conserved site;IPR028720,Protein HEG;IPR001881,EGF-like calcium-binding domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site","ENOG410IJZT,-;ENOG410Y1MK,-","GO:0001886,biological_process,endothelial cell morphogenesis;GO:0001570,biological_process,vasculogenesis;GO:0045216,biological_process,cell-cell junction organization;GO:0035264,biological_process,multicellular organism growth;GO:0005509,molecular_function,calcium ion binding;GO:0009791,biological_process,post-embryonic development;GO:0003281,biological_process,ventricular septum development;GO:0009986,cellular_component,cell surface;GO:0050878,biological_process,regulation of body fluid levels;GO:0001944,biological_process,vasculature development;GO:0048845,biological_process,venous blood vessel morphogenesis;GO:0055017,biological_process,cardiac muscle tissue growth;GO:0090271,biological_process,positive regulation of fibroblast growth factor production;GO:0016021,cellular_component,integral component of membrane;GO:0003209,biological_process,cardiac atrium morphogenesis;GO:0003017,biological_process,lymph circulation;GO:0009897,cellular_component,external side of plasma membrane;GO:0007043,biological_process,cell-cell junction assembly;GO:0016020,cellular_component,membrane;GO:0001885,biological_process,endothelial cell development;GO:0001945,biological_process,lymph vessel development;GO:0007507,biological_process,heart development;GO:0030324,biological_process,lung development;GO:0005911,cellular_component,cell-cell junction;GO:0060039,biological_process,pericardium development;GO:0001701,biological_process,in utero embryonic development;GO:0003222,biological_process,ventricular trabecula myocardium morphogenesis","-"]
["CAMSAP1",10.99098104,2.843642488,1.949011593,5.926186631,{"v":4.19e-13,"d":"4.19E-13"},{"v":8.35e-12,"d":"8.35E-12"},"ENSG00000130559","H2QY57,Uncharacterized protein","XP_520357.3,calmodulin-regulated spectrin-associated protein 1 isoform X4","PF17095,Spectrin-binding region of Ca2+-Calmodulin;PF08683,Microtubule-binding calmodulin-regulated spectrin-associated;PF11971,CAMSAP CH domain","IPR022613,Calmodulin-regulated spectrin-associated protein, CH domain;IPR011033,PRC-barrel-like superfamily;IPR036872,CH domain superfamily;IPR031372,CAMSAP, spectrin and Ca2+/calmodulin-binding region;IPR038209,CKK domain superfamily;IPR014797,CKK domain;IPR032940,Calmodulin-regulated spectrin-associated protein","KOG3654,Uncharacterized CH domain protein;ENOG4111D0B,-","GO:0005516,molecular_function,calmodulin binding;GO:0005874,cellular_component,microtubule;GO:0008017,molecular_function,microtubule binding;GO:0030507,molecular_function,spectrin binding;GO:0031175,biological_process,neuron projection development","-"]
["FAM120AOS",37.11712252,9.60864017,1.948650866,6.457520329,{"v":1.2e-14,"d":"1.20E-14"},{"v":3.37e-13,"d":"3.37E-13"},"ENSG00000188938","B3KPB1,cDNA FLJ31534 fis, clone NT2RI2000671","-","-","-","ENOG410IYU5,-;ENOG41113EZ,-","-","-"]
["RNF157",1.795712455,0.46197102,1.948510094,3.272675866,{"v":5.92e-05,"d":"5.92E-05"},0.000188811,"ENSG00000141576","G1QNY3,Ring finger protein 157","-","PF13920,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XRAE,-;KOG4265,Predicted E3 ubiquitin ligase","-","-"]
["ZNF28",8.903761725,2.303626497,1.947837563,5.107285663,{"v":2.37e-10,"d":"2.37E-10"},{"v":2.5e-09,"d":"2.50E-09"},"ENSG00000198538","A8K8T4,cDNA FLJ76364, highly similar to Homo sapiens zinc finger protein ZNF468","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;ENOG4110PUY,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["BRAF",4.026299188,1.041704594,1.947110673,4.769663605,{"v":2.8e-09,"d":"2.80E-09"},{"v":2.33E-8,"d":"2.33E-08"},"ENSG00000157764","H2QVI0,B-Raf proto-oncogene, serine/threonine kinase","-","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF02196,Raf-like Ras-binding domain;PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR020454,Diacylglycerol/phorbol-ester binding;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR003116,Raf-like Ras-binding;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR029071,Ubiquitin-like domain superfamily;IPR000719,Protein kinase domain","ENOG410Y4UP,-;KOG0193,Serine/threonine protein kinase RAF","GO:0031434,molecular_function,mitogen-activated protein kinase kinase binding;GO:0030154,biological_process,cell differentiation;GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:0000186,biological_process,activation of MAPKK activity;GO:0016310,biological_process,phosphorylation;GO:0016301,molecular_function,kinase activity;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005524,molecular_function,ATP binding;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0009968,biological_process,negative regulation of signal transduction;GO:0000165,biological_process,MAPK cascade;GO:0016740,molecular_function,transferase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0007165,biological_process,signal transduction;GO:0005057,molecular_function,signal transducer activity, downstream of receptor;GO:0035556,biological_process,intracellular signal transduction;GO:0046872,molecular_function,metal ion binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005622,cellular_component,intracellular;GO:0004709,molecular_function,MAP kinase kinase kinase activity;GO:0007275,biological_process,multicellular organism development","-"]
["DMXL1",2.499580477,0.646704168,1.946357519,4.490422786,{"v":2.35e-08,"d":"2.35E-08"},{"v":1.59e-07,"d":"1.59E-07"},"ENSG00000172869","F5H269,DmX-like protein 1","NP_001277250.1,dmX-like protein 1 isoform 1;XP_016864630.1,-","PF12234,RAVE protein 1 C terminal;PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR022033,RAVE complex protein Rav1 C-terminal;IPR017986,WD40-repeat-containing domain","ENOG410XPUM,-;KOG1064,RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily","-","-"]
["ARHGEF37",1.204249422,0.307722995,1.946158205,2.257592415,0.00285251,0.006181719,"ENSG00000183111","B4DUA3,cDNA FLJ50067, weakly similar to Dynamin-binding protein","-","PF07653,Variant SH3 domain;PF00621,RhoGEF domain;PF00018,SH3 domain","IPR035823,ARHGEF37, first C-terminal SH3 domain;IPR004148,BAR domain;IPR035636,ARHGEF37, SH3 domain 2;IPR027267,AH/BAR domain superfamily;IPR035899,Dbl homology (DH) domain superfamily;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain;IPR000219,Dbl homology (DH) domain","ENOG410YAZC,-;KOG3519,Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases","GO:0005737,cellular_component,cytoplasm;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function","-"]
["FAM69B",2.371088729,0.605886548,1.946158205,2.257592415,0.00285251,0.006181719,"ENSG00000165716","G3RJ05,Family with sequence similarity 69 member B","XP_004048941.1,protein FAM69B","PF12260,Protein-kinase domain of FAM69;PF14875,N-term cysteine-rich ER, FAM69","IPR029244,FAM69, N-terminal;IPR022049,FAM69, protein-kinase domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ITGB4",128.371074,33.34306319,1.944698552,9.097369508,{"v":6.03e-19,"d":"6.03E-19"},{"v":3.99e-17,"d":"3.99E-17"},"ENSG00000132470","A0A024R8T0,Integrin beta","NP_000204.3,integrin beta-4 isoform 1 precursor","PF03160,Calx-beta domain;PF00362,Integrin beta chain VWA domain;PF00041,ibronectin type III domain;PF07965,Integrin beta tail domain;PF17205,Integrin plexin domain;PF07974,-like domain","IPR003961,Fibronectin type III;IPR003644,Na-Ca exchanger/integrin-beta4;IPR015812,Integrin beta subunit;IPR036465,von Willebrand factor A-like domain superfamily;IPR038081,CalX-like domain superfamily;IPR002369,Integrin beta subunit, VWA domain;IPR036116,Fibronectin type III superfamily;IPR012896,Integrin beta subunit, tail;IPR013111,EGF-like domain, extracellular;IPR013783,Immunoglobulin-like fold;IPR016201,PSI domain;IPR013032,EGF-like, conserved site;IPR012013,Integrin beta-4 subunit;IPR033760,Integrin beta N-terminal;IPR036349,Integrin beta tail domain superfamily","KOG1226,Integrin beta subunit (N-terminal portion of extracellular region);ENOG410XP60,-","GO:0004872,-,-;GO:0008305,cellular_component,integrin complex;GO:0030054,cellular_component,cell junction;GO:0007155,biological_process,cell adhesion;GO:0007160,biological_process,cell-matrix adhesion;GO:0007154,biological_process,cell communication;GO:0005886,cellular_component,plasma membrane;GO:0048870,biological_process,cell motility;GO:0016020,cellular_component,membrane;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0031581,biological_process,hemidesmosome assembly;GO:0016021,cellular_component,integral component of membrane","K06525,ko05410,Hypertrophic cardiomyopathy (HCM);K06525,ko04512,ECM-receptor interaction;K06525,ko05414,Dilated cardiomyopathy;K06525,ko04151,PI3K-Akt signaling pathway;K06525,ko04810,Regulation of actin cytoskeleton;K06525,ko05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);K06525,ko04510,Focal adhesion"]
["SLC20A2",25.24421963,6.562150007,1.942869738,6.736900813,{"v":3.07e-15,"d":"3.07E-15"},{"v":9.99e-14,"d":"9.99E-14"},"ENSG00000168575","B2RBR4,Phosphate transporter","NP_001244110.1,-","PF01384,Phosphate transporter family","IPR001204,Phosphate transporter","KOG2493,Na+/Pi symporter;COG0306,Phosphate/sulphate permeases","GO:0055085,biological_process,transmembrane transport;GO:0006817,biological_process,phosphate ion transport;GO:0005315,molecular_function,inorganic phosphate transmembrane transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PTPRM",3.190121144,0.827432942,1.942419016,4.38099847,{"v":4.49e-08,"d":"4.49E-08"},{"v":2.85e-07,"d":"2.85E-07"},"ENSG00000173482","H2QE85,Uncharacterized protein","XP_003315855.1,receptor-type tyrosine-protein phosphatase mu isoform X10","PF00102,Protein-tyrosine phosphatase;PF00041,ibronectin type III domain;PF00629,MAM domain, meprin/A5/mu;PF00047,Immunoglobulin domain","IPR003961,Fibronectin type III;IPR029021,Protein-tyrosine phosphatase-like;IPR000387,Tyrosine specific protein phosphatases domain;IPR013151,Immunoglobulin;IPR000242,PTP type protein phosphatase;IPR036116,Fibronectin type III superfamily;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR000998,MAM domain;IPR016130,Protein-tyrosine phosphatase, active site;IPR003599,Immunoglobulin subtype;IPR007110,Immunoglobulin-like domain","COG5599,Protein tyrosine phosphatase;KOG4228,Protein tyrosine phosphatase","GO:0001937,biological_process,negative regulation of endothelial cell proliferation;GO:0005886,cellular_component,plasma membrane;GO:0016311,biological_process,dephosphorylation;GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0005737,cellular_component,cytoplasm;GO:0005913,cellular_component,cell-cell adherens junction;GO:0030027,cellular_component,lamellipodium;GO:0006470,biological_process,protein dephosphorylation;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0005001,molecular_function,transmembrane receptor protein tyrosine phosphatase activity;GO:0016020,cellular_component,membrane;GO:0007165,biological_process,signal transduction;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0010596,biological_process,negative regulation of endothelial cell migration;GO:0005911,cellular_component,cell-cell junction;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0010842,biological_process,retina layer formation;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031290,biological_process,retinal ganglion cell axon guidance;GO:0042493,biological_process,response to drug;GO:0045296,molecular_function,cadherin binding;GO:0031175,biological_process,neuron projection development;GO:0016791,molecular_function,phosphatase activity","-"]
["IDH1",8.550778373,2.220976539,1.941362958,4.722354322,{"v":4.73E-9,"d":"4.73E-09"},{"v":3.74e-08,"d":"3.74E-08"},"ENSG00000138413","V9HWJ2,Isocitrate dehydrogenase [NADP]","NP_001269315.1,-;NP_005887.2,isocitrate dehydrogenase;NP_001269316.1,-","PF00180,Isocitrate/isopropylmalate dehydrogenase","IPR024084,Isopropylmalate dehydrogenase-like domain;IPR019818,Isocitrate/isopropylmalate dehydrogenase, conserved site;IPR004790,Isocitrate dehydrogenase NADP-dependent","KOG1526,NADP-dependent isocitrate dehydrogenase;COG0538,Isocitrate dehydrogenases","GO:0051287,molecular_function,NAD binding;GO:0005829,cellular_component,cytosol;GO:0006979,biological_process,response to oxidative stress;GO:0004450,molecular_function,isocitrate dehydrogenase (NADP+) activity;GO:0071071,biological_process,regulation of phospholipid biosynthetic process;GO:0014070,biological_process,response to organic cyclic compound;GO:0050661,molecular_function,NADP binding;GO:0046872,molecular_function,metal ion binding;GO:0016616,molecular_function,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0004448,molecular_function,isocitrate dehydrogenase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0008585,biological_process,female gonad development;GO:0005739,cellular_component,mitochondrion;GO:0060696,biological_process,regulation of phospholipid catabolic process;GO:0048545,biological_process,response to steroid hormone;GO:0005777,cellular_component,peroxisome;GO:0055114,biological_process,oxidation-reduction process;GO:0006102,biological_process,isocitrate metabolic process;GO:0006099,biological_process,tricarboxylic acid cycle;GO:0006749,biological_process,glutathione metabolic process;GO:0000287,molecular_function,magnesium ion binding","K00031,ko04146,Peroxisome;K00031,ko01200,Carbon metabolism;K00031,ko00720,Carbon fixation pathways in prokaryotes;K00031,ko01210,2-Oxocarboxylic acid metabolism;K00031,ko01230,Biosynthesis of amino acids;K00031,ko00480,Glutathione metabolism;K00031,ko00020,Citrate cycle (TCA cycle)"]
["SBK1",3.044360837,0.787652512,1.941197615,3.382853444,{"v":2.32e-05,"d":"2.32E-05"},{"v":8.13e-05,"d":"8.13E-05"},"ENSG00000188322","G1RL98,Serine/threonine-protein kinase SBK1","XP_003261540.1,serine/threonine-protein kinase SBK1","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR016234,Serine/threonine-protein kinase, Sbk1;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG41112JR,-;KOG1345,Serine/threonine kinase","GO:0005737,cellular_component,cytoplasm;GO:0016740,molecular_function,transferase activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["MRPL35",9.550499445,2.481650537,1.940417013,4.584841109,{"v":1.16E-8,"d":"1.16E-08"},{"v":8.42E-8,"d":"8.42E-08"},"ENSG00000132313","G3SB05,Mitochondrial ribosomal protein L35","XP_004029611.1,-","PF01632,Ribosomal protein L35","IPR019338,Ribosomal protein L35, mitochondrial;IPR037229,Ribosomal protein L35 superfamily;IPR021137,Ribosomal protein L35","-","GO:0005840,cellular_component,ribosome;GO:0005762,cellular_component,mitochondrial large ribosomal subunit;GO:0006412,biological_process,translation;GO:0003735,molecular_function,structural constituent of ribosome;GO:0005622,cellular_component,intracellular","K02916,ko03010,Ribosome"]
["ATP8B1",8.710203766,2.265862669,1.940211993,5.229014178,1.21E-10,{"v":1.36e-09,"d":"1.36E-09"},"ENSG00000081923","K6ZES6,Phospholipid-transporting ATPase","XP_016789279.1,-;XP_016789278.1,-;XP_016789275.1,phospholipid-transporting ATPase IC isoform X1;XP_016789276.1,-;XP_016789277.1,-","PF13246,Cation transport ATPase (P-type);PF16209,Phospholipid-translocating ATPase N-terminal;PF00122,1-E2 ATPase;PF16212,Phospholipid-translocating P-type ATPase C-terminal","IPR032630,P-type ATPase, C-terminal;IPR036412,HAD-like superfamily;IPR023299,P-type ATPase, cytoplasmic domain N;IPR018303,P-type ATPase, phosphorylation site;IPR006539,P-type ATPase, subfamily IV;IPR023298,P-type ATPase, transmembrane domain superfamily;IPR032631,P-type ATPase, N-terminal;IPR030346,Phospholipid-transporting ATPase IC;IPR008250,P-type ATPase, A domain superfamily;IPR001757,P-type ATPase","ENOG410ITKD,-;ENOG410XPYK,-","GO:0045332,biological_process,phospholipid translocation;GO:0032534,biological_process,regulation of microvillus assembly;GO:0006855,biological_process,drug transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0004012,molecular_function,phospholipid-translocating ATPase activity;GO:0005524,molecular_function,ATP binding;GO:0005794,cellular_component,Golgi apparatus;GO:0016787,molecular_function,hydrolase activity;GO:0007605,biological_process,sensory perception of sound;GO:0060119,biological_process,inner ear receptor cell development;GO:0015914,biological_process,phospholipid transport;GO:0021650,biological_process,vestibulocochlear nerve formation;GO:0005319,molecular_function,lipid transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0008206,biological_process,bile acid metabolic process;GO:0015247,molecular_function,aminophospholipid transmembrane transporter activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0016324,cellular_component,apical plasma membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0000166,molecular_function,nucleotide binding;GO:0032420,cellular_component,stereocilium;GO:0015917,biological_process,aminophospholipid transport;GO:0000287,molecular_function,magnesium ion binding;GO:1901612,molecular_function,cardiolipin binding","-"]
["ZNF557",1.893999165,0.490025092,1.938116698,3.000599291,0.000148835,0.000435095,"ENSG00000130544","B2RD50,cDNA, FLJ96454, Homo sapiens zinc finger protein 557","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13465,Zinc-finger double domain","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["CHST12",0.706069936,0.182678003,1.938116698,3.000599291,0.000148835,0.000435095,"ENSG00000136213","G3RIC8,Carbohydrate sulfotransferase","XP_018886705.1,-","PF03567,Sulfotransferase family","IPR018011,Carbohydrate sulfotransferase 8-10;IPR005331,Sulfotransferase","-","GO:0008146,molecular_function,sulfotransferase activity;GO:0005975,biological_process,carbohydrate metabolic process;GO:0005794,cellular_component,Golgi apparatus;GO:0047756,molecular_function,chondroitin 4-sulfotransferase activity;GO:0016740,molecular_function,transferase activity;GO:0000139,cellular_component,Golgi membrane;GO:0030206,biological_process,chondroitin sulfate biosynthetic process;GO:0016051,biological_process,carbohydrate biosynthetic process;GO:0016020,cellular_component,membrane;GO:0030208,biological_process,dermatan sulfate biosynthetic process;GO:0016021,cellular_component,integral component of membrane","K04742,ko00532,Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate"]
["HS6ST2",15.7410929,4.105726272,1.937021464,5.647236804,{"v":5.23e-12,"d":"5.23E-12"},{"v":7.96e-11,"d":"7.96E-11"},"ENSG00000171004","G7NRL2,Heparan-sulfate 6-O-sulfotransferase","-","PF03567,Sulfotransferase family","IPR010635,Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase;IPR005331,Sulfotransferase;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0008146,molecular_function,sulfotransferase activity;GO:0016740,molecular_function,transferase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TANC1",4.710689833,1.229753564,1.935571675,5.502357768,{"v":1.04e-11,"d":"1.04E-11"},1.49E-10,"ENSG00000115183","K7AQ17,Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1","XP_016805357.1,protein TANC1 isoform X5;XP_016805358.1,-","PF12796,Ankyrin repeats (3 copies)","IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR002110,Ankyrin repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","GO:0097062,biological_process,dendritic spine maintenance;GO:0030425,cellular_component,dendrite;GO:0008542,biological_process,visual learning;GO:0043025,cellular_component,neuronal cell body;GO:0007520,biological_process,myoblast fusion;GO:0043679,cellular_component,axon terminus","-"]
["IRF2BP2",8.243747635,2.150204657,1.935220416,4.673428973,{"v":4.73E-9,"d":"4.73E-09"},{"v":3.74e-08,"d":"3.74E-08"},"ENSG00000168264","K7ARR5,Interferon regulatory factor 2 binding protein 2","XP_525097.3,interferon regulatory factor 2-binding protein 2 isoform X1","PF11261,Interferon regulatory factor 2-binding protein zinc finger","IPR022750,Interferon regulatory factor 2-binding protein 1 & 2, zinc finger","ENOG410IPPD,-;ENOG4110EVD,-","GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["GLCCI1",2.379774876,0.618681886,1.934971971,3.485101306,{"v":1.29E-5,"d":"1.29E-05"},{"v":4.8e-05,"d":"4.80E-05"},"ENSG00000106415","H2QU68,Uncharacterized protein","XP_518970.4,glucocorticoid-induced transcript 1 protein isoform X1","PF15388,Protein Family FAM117","IPR026639,Glucocorticoid-induced transcript 1 protein;IPR026642,Glucocorticoid-induced transcript 1/FAM117","ENOG4111PY2,-;ENOG410IEAU,-","-","-"]
["CLTC",16.83246552,4.401697175,1.934411096,6.985451262,8.98E-16,{"v":3.29e-14,"d":"3.29E-14"},"ENSG00000141367","A0A087WVQ6,Clathrin heavy chain","NP_001275582.1,clathrin heavy chain 1 isoform 2","PF09268,Clathrin, heavy-chain linker;PF00637,Region in Clathrin and VPS;PF01394,Clathrin propeller repeat;PF13838,Clathrin-H-link","IPR022365,Clathrin, heavy chain, propeller repeat;IPR016341,Clathrin, heavy chain;IPR015348,Clathrin, heavy chain, linker, core motif;IPR016025,Clathrin heavy chain, N-terminal;IPR000547,Clathrin, heavy chain/VPS, 7-fold repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR016024,Armadillo-type fold","KOG0985,Vesicle coat protein clathrin, heavy chain;ENOG410XPH1,-","GO:0030132,cellular_component,clathrin coat of coated pit;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0071439,cellular_component,clathrin complex;GO:0016020,cellular_component,membrane;GO:0005905,cellular_component,clathrin-coated pit;GO:0005768,cellular_component,endosome;GO:0072686,cellular_component,mitotic spindle;GO:0005198,molecular_function,structural molecule activity;GO:0032051,molecular_function,clathrin light chain binding;GO:0005764,cellular_component,lysosome;GO:0030659,cellular_component,cytoplasmic vesicle membrane;GO:0030130,cellular_component,clathrin coat of trans-Golgi network vesicle;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016192,biological_process,vesicle-mediated transport;GO:0048268,biological_process,clathrin coat assembly;GO:0006886,biological_process,intracellular protein transport","-"]
["SAMD9",17.18165311,4.493123827,1.933888322,6.235064388,{"v":8.75e-14,"d":"8.75E-14"},{"v":2.01e-12,"d":"2.01E-12"},"ENSG00000205413","H2R565,Sterile alpha motif domain containing 9","XP_009451888.1,-;XP_001167273.1,sterile alpha motif domain-containing protein 9","PF07647,SAM domain (Sterile alpha motif)","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","ENOG41124X3,-;ENOG410IETT,-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005829,cellular_component,cytosol;GO:0005737,cellular_component,cytoplasm;GO:0005769,cellular_component,early endosome;GO:0034058,biological_process,endosomal vesicle fusion","-"]
["C2CD5",5.199600755,1.357386664,1.933578955,4.530893248,{"v":2.06e-08,"d":"2.06E-08"},{"v":1.41e-07,"d":"1.41E-07"},"ENSG00000111731","A0A1D5QC36,C2 calcium dependent domain containing 5","XP_015006754.1,C2 domain-containing protein 5 isoform X11","-","IPR037785,C2CD5, C2 domain;IPR000008,C2 domain;IPR035892,C2 domain superfamily","-","-","-"]
["MTOR",7.857209197,2.054824806,1.933530254,5.932813273,{"v":6.03e-13,"d":"6.03E-13"},{"v":1.15e-11,"d":"1.15E-11"},"ENSG00000198793","K7B4P2,Serine/threonine-protein kinase mTOR","XP_016809442.1,-;XP_016809439.1,-","PF02259,AT domain;PF08771,KBP12-rapamycin binding domain;PF11865,omain of unknown function (DUF3385);PF02260,ATC domain;PF00454,Phosphatidylinositol 3- and 4-kinase","IPR009076,FKBP12-rapamycin binding domain;IPR018936,Phosphatidylinositol 3/4-kinase, conserved site;IPR026683,Serine/threonine-protein kinase TOR;IPR003152,FATC domain;IPR000403,Phosphatidylinositol 3-/4-kinase, catalytic domain;IPR036738,FKBP12-rapamycin binding domain superfamily;IPR014009,PIK-related kinase;IPR011989,Armadillo-like helical;IPR011009,Protein kinase-like domain superfamily;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR024585,Domain of unknown function DUF3385,  target of rapamycin protein;IPR016024,Armadillo-type fold;IPR003151,PIK-related kinase, FAT;IPR036940,Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily","COG5032,Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family;KOG0891,DNA-dependent protein kinase","GO:0031641,biological_process,regulation of myelination;GO:0016605,cellular_component,PML body;GO:0003007,biological_process,heart morphogenesis;GO:0055006,biological_process,cardiac cell development;GO:0051896,biological_process,regulation of protein kinase B signaling;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0010592,biological_process,positive regulation of lamellipodium assembly;GO:0006207,biological_process,'de novo' pyrimidine nucleobase biosynthetic process;GO:0038202,biological_process,TORC1 signaling;GO:0051549,biological_process,positive regulation of keratinocyte migration;GO:0032868,biological_process,response to insulin;GO:0035264,biological_process,multicellular organism growth;GO:0048714,biological_process,positive regulation of oligodendrocyte differentiation;GO:0031529,biological_process,ruffle organization;GO:0009267,biological_process,cellular response to starvation;GO:0030030,biological_process,cell projection organization;GO:0004672,molecular_function,protein kinase activity;GO:0018107,biological_process,peptidyl-threonine phosphorylation;GO:0001156,molecular_function,TFIIIC-class transcription factor binding;GO:0071233,biological_process,cellular response to leucine;GO:0003179,biological_process,heart valve morphogenesis;GO:0043200,biological_process,response to amino acid;GO:0010507,biological_process,negative regulation of autophagy;GO:0007281,biological_process,germ cell development;GO:0008361,biological_process,regulation of cell size;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0016301,molecular_function,kinase activity;GO:0045670,biological_process,regulation of osteoclast differentiation;GO:0001558,biological_process,regulation of cell growth;GO:0016020,cellular_component,membrane;GO:0005737,cellular_component,cytoplasm;GO:0045945,biological_process,positive regulation of transcription by RNA polymerase III;GO:0001030,molecular_function,RNA polymerase III type 1 promoter DNA binding;GO:0055013,biological_process,cardiac muscle cell development;GO:0044877,molecular_function,protein-containing complex binding;GO:0043022,molecular_function,ribosome binding;GO:0016310,biological_process,phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0043087,biological_process,regulation of GTPase activity;GO:0046889,biological_process,positive regulation of lipid biosynthetic process;GO:0005829,cellular_component,cytosol;GO:0006112,biological_process,energy reserve metabolic process;GO:0042802,molecular_function,identical protein binding;GO:1903691,biological_process,positive regulation of wound healing, spreading of epidermal cells;GO:0031929,biological_process,TOR signaling;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0010628,biological_process,positive regulation of gene expression;GO:0009791,biological_process,post-embryonic development;GO:0030425,cellular_component,dendrite;GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:0001032,molecular_function,RNA polymerase III type 3 promoter DNA binding;GO:0007584,biological_process,response to nutrient;GO:0090559,biological_process,regulation of membrane permeability;GO:0005634,cellular_component,nucleus;GO:0016740,molecular_function,transferase activity;GO:0045792,biological_process,negative regulation of cell size;GO:0031932,cellular_component,TORC2 complex;GO:0010831,biological_process,positive regulation of myotube differentiation;GO:0060048,biological_process,cardiac muscle contraction;GO:0071456,biological_process,cellular response to hypoxia;GO:0051219,molecular_function,phosphoprotein binding;GO:0031931,cellular_component,TORC1 complex;GO:0031669,biological_process,cellular response to nutrient levels;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0045859,biological_process,regulation of protein kinase activity;GO:0012505,cellular_component,endomembrane system;GO:0050882,biological_process,voluntary musculoskeletal movement;GO:0030838,biological_process,positive regulation of actin filament polymerization;GO:0051496,biological_process,positive regulation of stress fiber assembly;GO:0016242,biological_process,negative regulation of macroautophagy;GO:0001031,molecular_function,RNA polymerase III type 2 promoter DNA binding;GO:0048738,biological_process,cardiac muscle tissue development;GO:0005764,cellular_component,lysosome;GO:0046777,biological_process,protein autophosphorylation;GO:0071230,biological_process,cellular response to amino acid stimulus;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:1901838,biological_process,positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0051534,-,-;GO:0034198,biological_process,cellular response to amino acid starvation;GO:1990253,biological_process,cellular response to leucine starvation;GO:0045727,biological_process,positive regulation of translation;GO:0001934,biological_process,positive regulation of protein phosphorylation","K07203,ko01522,Endocrine resistance;K07203,ko04139,Regulation of mitophagy - yeast;K07203,ko05215,Prostate cancer;K07203,ko04072,Phospholipase D signaling pathway;K07203,ko04151,PI3K-Akt signaling pathway;K07203,ko01521,EGFR tyrosine kinase inhibitor resistance;K07203,ko05230,Central carbon metabolism in cancer;K07203,ko04920,Adipocytokine signaling pathway;K07203,ko04919,Thyroid hormone signaling pathway;K07203,ko04012,ErbB signaling pathway;K07203,ko05214,Glioma;K07203,ko04212,Longevity regulating pathway - worm;K07203,ko04213,Longevity regulating pathway - multiple species;K07203,ko04152,AMPK signaling pathway;K07203,ko04910,Insulin signaling pathway;K07203,ko04150,mTOR signaling pathway;K07203,ko05206,MicroRNAs in cancer;K07203,ko05221,Acute myeloid leukemia;K07203,ko04930,Type II diabetes mellitus;K07203,ko04630,Jak-STAT signaling pathway;K07203,ko05231,Choline metabolism in cancer;K07203,ko04066,HIF-1 signaling pathway;K07203,ko05205,Proteoglycans in cancer;K07203,ko04211,Longevity regulating pathway;K07203,ko04931,Insulin resistance;K07203,ko05200,Pathways in cancer"]
["RFFL",7.504320851,1.963209081,1.932316327,5.367985665,{"v":2.9E-11,"d":"2.90E-11"},{"v":3.77e-10,"d":"3.77E-10"},"ENSG00000092871","G3QNH3,Ring finger and FYVE like domain containing E3 ubiquitin protein ligase","XP_004041982.1,-;XP_018883181.1,-","PF13920,Zinc finger, C3HC4 type (RING finger)","IPR036361,SAP domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR001841,Zinc finger, RING-type","-","GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0019901,molecular_function,protein kinase binding;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1901797,biological_process,negative regulation of signal transduction by p53 class mediator;GO:0002039,molecular_function,p53 binding;GO:2001271,biological_process,negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:0002020,molecular_function,protease binding;GO:0046872,molecular_function,metal ion binding;GO:0070936,biological_process,protein K48-linked ubiquitination;GO:0002947,cellular_component,tumor necrosis factor receptor superfamily complex;GO:0005737,cellular_component,cytoplasm;GO:0005886,cellular_component,plasma membrane;GO:1902042,biological_process,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0010804,biological_process,negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010008,cellular_component,endosome membrane","-"]
["SAR1B",2.404275848,0.627650492,1.932253083,4.133304717,{"v":2.72E-7,"d":"2.72E-07"},{"v":1.44E-6,"d":"1.44E-06"},"ENSG00000152700","A0A1S3GEP1,GTP-binding protein SAR1b","XP_012886467.1,-;XP_012886466.1,-","-","IPR006689,Small GTPase superfamily, ARF/SAR type;IPR005225,Small GTP-binding protein domain;IPR006687,Small GTPase superfamily, SAR1-type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005794,cellular_component,Golgi apparatus;GO:0005525,molecular_function,GTP binding;GO:0015031,biological_process,protein transport;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005622,cellular_component,intracellular;GO:0016192,biological_process,vesicle-mediated transport;GO:0000166,molecular_function,nucleotide binding;GO:0006886,biological_process,intracellular protein transport","-"]
["TMEM182",1.557434853,0.402947463,1.93198835,2.475001338,0.002758242,6.013872E-3,"ENSG00000170417","G3RK48,Transmembrane protein 182","-","PF13903,PMP-22/EMP/MP20/Claudin tight junction","-","-","-","-"]
["GCNT4",1.36815352,0.353975634,1.93198835,2.475001338,0.002758242,6.013872E-3,"ENSG00000176928","H2REA9,Glucosaminyl","XP_009447290.1,-;XP_016808627.1,-;XP_016808630.1,-;XP_016808629.1,-;XP_016808632.1,-;XP_016808631.1,-","PF02485,Core-2/I-Branching enzyme","IPR003406,Glycosyl transferase, family 14","ENOG410XQ7M,-;KOG0799,Branching enzyme","GO:0008375,molecular_function,acetylglucosaminyltransferase activity;GO:0042403,biological_process,thyroid hormone metabolic process;GO:0048872,biological_process,homeostasis of number of cells;GO:0048729,biological_process,tissue morphogenesis;GO:0002121,biological_process,inter-male aggressive behavior;GO:0060993,biological_process,kidney morphogenesis;GO:0016020,cellular_component,membrane","K09663,ko00512,Mucin type O-Glycan biosynthesis"]
["AIM1L",2.14365316,0.558104999,1.930327173,3.133036837,0.000156542,0.000455064,"ENSG00000176092","G3QXJ2,Crystallin beta-gamma domain containing 2","XP_018868748.1,absent in melanoma 1-like protein","PF00030,Beta/Gamma crystallin","IPR035992,Ricin B-like lectins;IPR011024,Gamma-crystallin-like;IPR001064,Beta/gamma crystallin;IPR000772,Ricin B, lectin domain","-","-","-"]
["KCNK2",3.218769233,0.838013926,1.930327173,3.133036837,0.000156542,0.000455064,"ENSG00000082482","G7NTZ8,Uncharacterized protein","XP_005540898.1,-","PF07885,Ion channel","IPR003976,Two pore domain potassium channel, TREK;IPR013099,Potassium channel domain;IPR003280,Two pore domain potassium channel","-","GO:0005267,molecular_function,potassium channel activity;GO:0015271,molecular_function,outward rectifier potassium channel activity;GO:0022841,molecular_function,potassium ion leak channel activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0005249,molecular_function,voltage-gated potassium channel activity;GO:0006811,biological_process,ion transport;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0008076,cellular_component,voltage-gated potassium channel complex;GO:0006813,biological_process,potassium ion transport;GO:0016021,cellular_component,integral component of membrane;GO:0042391,biological_process,regulation of membrane potential","K04913,ko04971,Gastric acid secretion"]
["LMAN2L",4.645768808,1.209536527,1.930327173,3.133036837,0.000156542,0.000455064,"ENSG00000114988","H2QID3,Lectin, mannose binding 2 like","XP_515742.2,VIP36-like protein isoform X1","PF03388,Legume-like lectin family","IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR005052,Legume-like lectin","ENOG410YH8V,-;KOG3839,Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans","GO:0015031,biological_process,protein transport;GO:0005794,cellular_component,Golgi apparatus;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF800",3.033324832,0.791867466,1.929607576,3.580490685,{"v":1.43E-5,"d":"1.43E-05"},{"v":5.26e-05,"d":"5.26E-05"},"ENSG00000048405","H2R4Z3,Zinc finger protein 800","XP_001150842.2,-","PF00096,Zinc finger, C2H2 type;PF16624,Unstructured region upstream of a zinc-finger;PF16622,zinc-finger C2H2-type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["RP1-309K20.6",87.4136544,22.92141072,1.929331813,5.618234223,{"v":5.53e-12,"d":"5.53E-12"},{"v":8.37e-11,"d":"8.37E-11"},"ENSG00000272897","H0YGN5,Uncharacterized protein","-","PF00266,Aminotransferase class-V","IPR010240,Cysteine desulfurase IscS;IPR015422,Pyridoxal phosphate-dependent transferase domain 1;IPR000192,Aminotransferase class V domain;IPR015424,Pyridoxal phosphate-dependent transferase","COG1104,Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes;KOG1549,Cysteine desulfurase NFS1","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0031071,molecular_function,cysteine desulfurase activity;GO:0003824,molecular_function,catalytic activity;GO:0044571,biological_process,[2Fe-2S] cluster assembly","-"]
["HSD17B12",4.786769961,1.254134135,1.928640854,4.622772599,{"v":8.21e-09,"d":"8.21E-09"},{"v":6.15e-08,"d":"6.15E-08"},"ENSG00000149084","B3KQJ0,cDNA FLJ90530 fis, clone NT2RP4002187, highly similar to Homo sapiens hydroxysteroid","-","PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily;IPR020904,Short-chain dehydrogenase/reductase, conserved site;IPR002347,Short-chain dehydrogenase/reductase SDR","COG0300,Short-chain dehydrogenases of various substrate specificities;KOG1014,17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TSC1",10.44623382,2.744028447,1.927270341,6.052956738,{"v":3.86e-13,"d":"3.86E-13"},{"v":7.74e-12,"d":"7.74E-12"},"ENSG00000165699","X5D9D2,Tuberous sclerosis 1 isoform A","XP_005272268.1,-;XP_006717334.1,-;XP_016870585.1,-;XP_016870586.1,-;XP_011517281.1,-;NP_000359.1,hamartin isoform 1","PF04388,Hamartin protein","IPR007483,Hamartin","ENOG410IG36,-;ENOG411020J,-","GO:0045792,biological_process,negative regulation of cell size;GO:0010977,biological_process,negative regulation of neuron projection development;GO:0005856,cellular_component,cytoskeleton;GO:1901214,biological_process,regulation of neuron death;GO:0030030,biological_process,cell projection organization;GO:0050808,biological_process,synapse organization;GO:0043379,biological_process,memory T cell differentiation;GO:0046323,biological_process,glucose import;GO:0005634,cellular_component,nucleus;GO:0021987,biological_process,cerebral cortex development;GO:0005737,cellular_component,cytoplasm;GO:0047485,molecular_function,protein N-terminus binding;GO:0051291,biological_process,protein heterooligomerization;GO:0008344,biological_process,adult locomotory behavior;GO:0005829,cellular_component,cytosol;GO:1903204,biological_process,negative regulation of oxidative stress-induced neuron death;GO:0005811,cellular_component,lipid droplet;GO:0001822,biological_process,kidney development;GO:0055007,biological_process,cardiac muscle cell differentiation;GO:0002250,biological_process,adaptive immune response;GO:0042995,cellular_component,cell projection;GO:0042552,biological_process,myelination;GO:0051893,biological_process,regulation of focal adhesion assembly;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0007399,biological_process,nervous system development;GO:0030426,cellular_component,growth cone;GO:0001843,biological_process,neural tube closure;GO:0034260,biological_process,negative regulation of GTPase activity;GO:0045859,biological_process,regulation of protein kinase activity;GO:0090650,biological_process,cellular response to oxygen-glucose deprivation;GO:0051496,biological_process,positive regulation of stress fiber assembly;GO:0032007,biological_process,negative regulation of TOR signaling;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0016239,biological_process,positive regulation of macroautophagy;GO:0021766,biological_process,hippocampus development;GO:0006813,biological_process,potassium ion transport;GO:0016242,biological_process,negative regulation of macroautophagy;GO:0032794,molecular_function,GTPase activating protein binding","K07206,ko04910,Insulin signaling pathway;K07206,ko05231,Choline metabolism in cancer;K07206,ko04072,Phospholipase D signaling pathway;K07206,ko04151,PI3K-Akt signaling pathway;K07206,ko04211,Longevity regulating pathway;K07206,ko04150,mTOR signaling pathway;K07206,ko04152,AMPK signaling pathway"]
["TIMP2",25.8832823,6.805720411,1.926246603,6.540863568,1.58E-14,{"v":4.33e-13,"d":"4.33E-13"},"ENSG00000035862","H9YV73,Metalloproteinase inhibitor 2","-","PF00965,Tissue inhibitor of metalloproteinase","IPR008993,Tissue inhibitor of metalloproteinases-like, OB-fold;IPR015613,Metalloproteinase inhibitor 2;IPR027465,Proteinase inhibitor I35b (TIMP), C-terminal;IPR030490,Tissue inhibitor of metalloproteinase, conserved site;IPR001134,Netrin domain;IPR001820,Protease inhibitor I35 (TIMP)","ENOG41103NU,-;KOG4745,Metalloproteinase inhibitor TIMP and related proteins","GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0008191,molecular_function,metalloendopeptidase inhibitor activity;GO:0005576,cellular_component,extracellular region","-"]
["IGF2BP2",234.0499468,61.58827162,1.925963425,9.45325959,{"v":5.02e-19,"d":"5.02E-19"},{"v":3.4e-17,"d":"3.40E-17"},"ENSG00000073792","F8W930,Insulin-like growth factor 2 mRNA-binding protein 2","NP_001278798.1,insulin-like growth factor 2 mRNA-binding protein 2 isoform c","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF00013,KH domain","IPR004088,K Homology domain, type 1;IPR004087,K Homology domain;IPR028743,Insulin-like growth factor 2 mRNA-binding protein 2;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034843,IGF2BP2, RNA recognition motif 1;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR036612,K Homology domain, type 1 superfamily","ENOG410ZKB4,-;KOG2193,IGF-II mRNA-binding protein IMP, contains RRM and KH domains","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0003729,molecular_function,mRNA binding","-"]
["KIAA1109",3.955735688,1.040455492,1.925014222,5.70465923,3.65E-12,{"v":5.8E-11,"d":"5.80E-11"},"ENSG00000138688","H2QQ42,Uncharacterized protein","XP_517422.2,uncharacterized protein KIAA1109 homolog isoform X11","PF10479,ragile site-associated protein C-terminus","IPR033616,Protein KIAA1109;IPR018863,Fragile site-associated protein, C-terminal","ENOG410XT7P,-;KOG3596,Uncharacterized conserved protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["KMT2B",7.993113169,2.103880472,1.924014626,5.725478972,{"v":3.1e-12,"d":"3.10E-12"},5.01E-11,"ENSG00000272333","H2QG38,Histone-lysine N-methyltransferase","XP_016791193.1,histone-lysine N-methyltransferase 2B isoform X1","PF00628,PHD-finger;PF02008,CXXC zinc finger domain;PF13771,PHD-like zinc-binding domain;PF05964,/Y-rich N-terminus;PF00856,SET domain;PF05965,/Y rich C-terminus","IPR001965,Zinc finger, PHD-type;IPR016569,Methyltransferase, trithorax;IPR036427,Bromodomain-like superfamily;IPR003889,FY-rich, C-terminal;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR002857,Zinc finger, CXXC-type;IPR003888,FY-rich, N-terminal;IPR003616,Post-SET domain;IPR001214,SET domain;IPR011011,Zinc finger, FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger;IPR034732,Extended PHD (ePHD) domain","KOG1084,Transcription factor TCF20;COG2940,Proteins containing SET domain","GO:0001541,biological_process,ovarian follicle development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0042800,molecular_function,histone methyltransferase activity (H3-K4 specific);GO:0080182,biological_process,histone H3-K4 trimethylation;GO:0051569,biological_process,regulation of histone H3-K4 methylation;GO:0034968,biological_process,histone lysine methylation;GO:0009994,biological_process,oocyte differentiation;GO:0005634,cellular_component,nucleus;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0016458,biological_process,gene silencing;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0007613,biological_process,memory;GO:0008270,molecular_function,zinc ion binding;GO:0032259,biological_process,methylation;GO:0051568,biological_process,histone H3-K4 methylation;GO:0035097,cellular_component,histone methyltransferase complex;GO:0030728,biological_process,ovulation;GO:0008168,molecular_function,methyltransferase activity","-"]
["TMEM39A",2.582540489,0.675848096,1.923909,3.254152366,{"v":8.23e-05,"d":"8.23E-05"},0.00025344,"ENSG00000176142","G3R863,Transmembrane protein 39A","XP_004036159.1,-;XP_018880208.1,-","PF10271,Putative transmembrane protein","IPR019397,Uncharacterised protein family TMEM39","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF286B",6.981747983,1.837677377,1.92232787,4.750424713,{"v":5.25e-09,"d":"5.25E-09"},{"v":4.1e-08,"d":"4.10E-08"},"ENSG00000249459","G1RX43,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["HELZ2",0.72816388,0.190091506,1.921720553,2.663310629,0.001279284,0.003007857,"ENSG00000130589","K7D3T3,Peroxisomal proliferator-activated receptor A interacting complex 285","-","PF13087,AAA domain;PF13086,AAA domain;PF00773,RNB domain","IPR031191,Helicase with zinc finger domain 2;IPR022966,Ribonuclease II/R, conserved site;IPR012340,Nucleic acid-binding, OB-fold;IPR036236,Zinc finger C2H2 superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG2102,Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3;KOG1804,RNA helicase;COG1112,Superfamily I DNA and RNA helicases and helicase subunits;COG0557,Exoribonuclease R","GO:1903506,biological_process,regulation of nucleic acid-templated transcription;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity","-"]
["ELAC2",43.41272948,11.46434749,1.920461648,7.452477847,1.88E-16,{"v":7.73e-15,"d":"7.73E-15"},"ENSG00000006744","A0A0S2Z5M8,ElaC homolog 2","NP_060597.4,zinc phosphodiesterase ELAC protein 2 isoform 1","PF12706,Beta-lactamase superfamily domain;PF13691,tRNase Z endonuclease","IPR027794,tRNase Z endonuclease;IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR001279,Metallo-beta-lactamase","-","GO:0042645,cellular_component,mitochondrial nucleoid;GO:0008033,biological_process,tRNA processing;GO:0005739,cellular_component,mitochondrion;GO:0005654,cellular_component,nucleoplasm","K00784,ko03013,RNA transport"]
["GGA3",8.976279588,2.36865141,1.919730746,5.272859369,1.08E-10,{"v":1.22e-09,"d":"1.22E-09"},"ENSG00000125447","K7CPU6,Golgi-associated, gamma adaptin ear containing, ARF binding protein 3","XP_016788413.1,ADP-ribosylation factor-binding protein GGA3 isoform X1","PF00790,VHS domain;PF03127,AT domain;PF02883,Adaptin C-terminal domain","IPR013041,Clathrin adaptor, appendage, Ig-like subdomain superfamily;IPR008152,Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain;IPR008942,ENTH/VHS;IPR038425,GAT domain superfamily;IPR002014,VHS domain;IPR008153,Gamma-adaptin ear (GAE) domain;IPR027422,ADP-ribosylation factor-binding protein GGA3;IPR004152,GAT domain","ENOG410Y26G,-;KOG1087,Cytosolic sorting protein GGA2/TOM1","GO:0030306,molecular_function,ADP-ribosylation factor binding;GO:0005794,cellular_component,Golgi apparatus;GO:0045732,biological_process,positive regulation of protein catabolic process;GO:0005802,cellular_component,trans-Golgi network;GO:0030131,cellular_component,clathrin adaptor complex;GO:0005622,cellular_component,intracellular;GO:0016192,biological_process,vesicle-mediated transport;GO:0006886,biological_process,intracellular protein transport","K12404,ko04142,Lysosome"]
["MT1E",24.82948287,6.540810215,1.919214035,4.123291445,{"v":3.54e-07,"d":"3.54E-07"},{"v":1.83e-06,"d":"1.83E-06"},"ENSG00000169715","G3R2Y8,Uncharacterized protein","-","PF00131,Metallothionein","IPR000006,Metallothionein, vertebrate;IPR017854,Metallothionein domain superfamily;IPR018064,Metallothionein, vertebrate, metal binding site;IPR023587,Metallothionein domain superfamily, vertebrate;IPR003019,Metallothionein","-","GO:0046872,molecular_function,metal ion binding","-"]
["EIF4G3",15.76303799,4.165792028,1.918969447,6.594843079,{"v":1.39e-14,"d":"1.39E-14"},{"v":3.86e-13,"d":"3.86E-13"},"ENSG00000075151","A0A0U1RQK7,Eukaryotic translation initiation factor 4 gamma 3","-","PF02020,eIF4-gamma/eIF5/eIF2-epsilon;PF02854,MIF4G domain;PF02847,MA3 domain","IPR003307,W2 domain;IPR016021,MIF4G-like domain superfamily;IPR003890,MIF4G-like, type 3;IPR037585,Eukaryotic translation initiation factor 4 gamma 3;IPR016024,Armadillo-type fold;IPR003891,Initiation factor eIF-4 gamma, MA3","-","GO:0003743,molecular_function,translation initiation factor activity;GO:0003723,molecular_function,RNA binding;GO:0006413,biological_process,translational initiation;GO:0000339,molecular_function,RNA cap binding","-"]
["PCDHA1",2.673813968,0.702763421,1.918529286,3.365740202,{"v":3.21e-05,"d":"3.21E-05"},0.000108678,"ENSG00000204970","F7GSV9,Protocadherin alpha subfamily C, 2","XP_014996286.1,protocadherin alpha 5 isoform X9","PF08266,Cadherin-like;PF00028,Cadherin domain;PF15974,Cadherin C-terminal cytoplasmic tail, catenin-binding region;PF16492,Cadherin cytoplasmic C-terminal","IPR030740,Protocadherin alpha-1;IPR013164,Cadherin, N-terminal;IPR032455,Cadherin, cytoplasmic C-terminal domain;IPR031904,Cadherin, C-terminal catenin-binding domain;IPR002126,Cadherin;IPR015919,Cadherin-like;IPR020894,Cadherin conserved site","-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["LRCH4",5.625701014,1.48545873,1.917534143,4.659730949,{"v":7.32e-09,"d":"7.32E-09"},{"v":5.56e-08,"d":"5.56E-08"},"ENSG00000077454","H2QV32,Leucine rich repeats and calponin homology domain containing 4","XP_016801659.1,-;XP_009452074.1,leucine-rich repeat and calponin homology domain-containing protein 4 isoform X1","PF13855,Leucine rich repeat;PF00307,Calponin homology (CH) domain","IPR001611,Leucine-rich repeat;IPR001715,Calponin homology domain;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily;IPR036872,CH domain superfamily","COG4886,Leucine-rich repeat (LRR) protein;KOG0532,Leucine-rich repeat (LRR) protein, contains calponin homology domain","GO:0005737,cellular_component,cytoplasm;GO:0045199,biological_process,maintenance of epithelial cell apical/basal polarity;GO:0016323,cellular_component,basolateral plasma membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["KIAA0355",3.661069407,0.966429252,1.916474065,4.185010429,{"v":3.2e-07,"d":"3.20E-07"},{"v":1.67e-06,"d":"1.67E-06"},"ENSG00000166398","K7DPA5,KIAA0355","-","PF15923,omain of unknown function (DUF4745)","IPR031813,Domain of unknown function DUF4745","ENOG4110CME,-;ENOG410IFZG,-","-","-"]
["HDAC7",5.23809144,1.386166871,1.915291001,5.081932835,{"v":4.92e-10,"d":"4.92E-10"},{"v":4.88e-09,"d":"4.88E-09"},"ENSG00000061273","J3KPH8,Histone deacetylase","-","PF00850,Histone deacetylase domain","IPR037138,Histone deacetylase domain superfamily;IPR023696,Ureohydrolase domain superfamily;IPR023801,Histone deacetylase domain;IPR017320,Histone deacetylase class II, eukaryotic;IPR000286,Histone deacetylase superfamily","KOG1343,Histone deacetylase complex, catalytic component HDA1;COG0123,Deacetylases, including yeast histone deacetylase and acetoin utilization protein","GO:0032041,molecular_function,NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0016787,molecular_function,hydrolase activity;GO:0000118,cellular_component,histone deacetylase complex;GO:0070932,biological_process,histone H3 deacetylation;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0006325,biological_process,chromatin organization;GO:0016575,biological_process,histone deacetylation;GO:0005829,cellular_component,cytosol;GO:0004407,molecular_function,histone deacetylase activity;GO:0005634,cellular_component,nucleus","-"]
["THSD4",1.799281268,0.475864067,1.913966715,4.244177296,{"v":2.1E-7,"d":"2.10E-07"},{"v":1.15E-6,"d":"1.15E-06"},"ENSG00000187720","H2QZD1,Uncharacterized protein","XP_009427741.2,thrombospondin type-1 domain-containing protein 4 isoform X1","PF05986,ADAM-TS Spacer 1;PF00090,Thrombospondin type 1 domain;PF08686,PLAC (protease and lacunin) domain","IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR010909,PLAC;IPR010294,ADAM-TS Spacer 1;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","KOG4597,Serine proteinase inhibitor (KU family) with thrombospondin repeats;ENOG41102GD,-;KOG3538,Disintegrin metalloproteinases with thrombospondin repeats","GO:0006508,biological_process,proteolysis;GO:0048251,biological_process,elastic fiber assembly;GO:0005578,,;GO:0001527,cellular_component,microfibril;GO:0008233,molecular_function,peptidase activity","-"]
["IQCK",3.233985556,0.853119324,1.913954832,3.469198598,{"v":1.77E-5,"d":"1.77E-05"},{"v":6.38e-05,"d":"6.38E-05"},"ENSG00000174628","G2HGD3,IQ motif containing K","NP_001233405.1,IQ domain-containing protein K;XP_016783944.1,-","-","-","ENOG410IK7E,-;ENOG4111M9I,-","-","-"]
["RHOQ",2.159195952,0.567505426,1.913937894,2.829426844,0.000426762,1.118183E-3,"ENSG00000119729","I3LYG2,Ras homolog family member Q","XP_005324558.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR003578,Small GTPase superfamily, Rho type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1100,GTPase SAR1 and related small G proteins;KOG0393,Ras-related small GTPase, Rho type","GO:0032427,molecular_function,GBD domain binding;GO:0045121,cellular_component,membrane raft;GO:0046326,biological_process,positive regulation of glucose import;GO:0005884,cellular_component,actin filament;GO:0005525,molecular_function,GTP binding;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0046039,biological_process,GTP metabolic process;GO:0030866,biological_process,cortical actin cytoskeleton organization;GO:0008286,biological_process,insulin receptor signaling pathway;GO:0005522,molecular_function,profilin binding;GO:1903077,biological_process,negative regulation of protein localization to plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0005622,cellular_component,intracellular;GO:0003924,molecular_function,GTPase activity;GO:0051491,biological_process,positive regulation of filopodium assembly;GO:0008360,biological_process,regulation of cell shape;GO:0000166,molecular_function,nucleotide binding;GO:0032869,biological_process,cellular response to insulin stimulus","-"]
["CCSER1",0.956398744,0.251372033,1.913937894,2.829426844,0.000426762,1.118183E-3,"ENSG00000184305","F6VAY1,Coiled-coil serine rich protein 1","XP_014994281.1,serine-rich coiled-coil domain-containing protein 1 isoform X1","-","IPR029628,Serine-rich coiled-coil domain-containing protein 1;IPR029627,Serine-rich coiled-coil domain-containing protein","ENOG410IEYT,-;ENOG410YA7F,-","-","-"]
["RP11-324I22.4",2.690766519,0.696168793,1.913866405,1.626326423,0.03847433,0.062458283,"ENSG00000271335","A0A1B0GTR1,Propionyl-CoA carboxylase alpha chain, mitochondrial","-","PF00289,Biotin carboxylase, N-terminal domain","IPR005481,Biotin carboxylase-like, N-terminal domain;IPR016185,Pre-ATP-grasp domain superfamily;IPR011764,Biotin carboxylation domain","-","-","-"]
["HOXB-AS3",1.986075444,0.513847535,1.913866405,1.626326423,0.03847433,0.062458283,"ENSG00000233101","D3DTV8,HCG2042068, isoform CRA_d","-","-","-","-","-","-"]
["ZNF30",1.38410285,0.358102126,1.913866405,1.626326423,0.03847433,0.062458283,"ENSG00000168661","H2QG13,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ASTE1",1.108655478,0.286836981,1.913866405,1.626326423,0.03847433,0.062458283,"ENSG00000034533","D6RG30,Asteroid homolog 1","NP_001275879.1,protein asteroid homolog 1 isoform 1","PF12813,XPG domain containing;PF00752,XPG N-terminal domain","IPR006085,XPG N-terminal;IPR026832,Asteroid;IPR029060,PIN-like domain superfamily","ENOG410IFPJ,-;ENOG4111F5P,-","GO:0006281,biological_process,DNA repair;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0004518,molecular_function,nuclease activity","-"]
["PAXIP1-AS2",1.277526,0.330528021,1.913866405,1.626326423,0.03847433,0.062458283,"ENSG00000214106","H2RCF1,Uncharacterized protein","-","-","-","-","-","-"]
["E2F3",11.72585923,3.109122542,1.91284452,5.296496011,{"v":8.62e-11,"d":"8.62E-11"},{"v":9.96e-10,"d":"9.96E-10"},"ENSG00000112242","H2PI15,E2F transcription factor 3","-","PF02319,2F/DP family winged-helix DNA-binding domain;PF16421,2F transcription factor CC-MB domain","IPR003316,E2F/DP family, winged-helix DNA-binding domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR037241,E2F-DP heterodimerization region;IPR015633,E2F Family;IPR036390,Winged helix DNA-binding domain superfamily;IPR032198,E2F transcription factor, CC-MB domain","KOG2577,Transcription factor E2F/dimerization partner (TDP);ENOG410XNYI,-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0046983,molecular_function,protein dimerization activity;GO:1905461,biological_process,positive regulation of vascular associated smooth muscle cell apoptotic process;GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0070345,biological_process,negative regulation of fat cell proliferation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0006351,biological_process,transcription, DNA-templated;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0090575,cellular_component,RNA polymerase II transcription factor complex;GO:0001047,molecular_function,core promoter binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["ATPAF2",23.94233312,6.360110005,1.911410263,6.415098575,{"v":4.48e-14,"d":"4.48E-14"},{"v":1.1E-12,"d":"1.10E-12"},"ENSG00000171953","H2QCD7,ATP synthase mitochondrial F1 complex assembly factor 2","XP_001159122.1,ATP synthase mitochondrial F1 complex assembly factor 2 isoform X1","PF07542,ATP12 chaperone protein","IPR011419,ATP12, ATP synthase F1-assembly protein;IPR023335,ATP12 orthogonal Bundle domain superfamily","KOG3015,F1-ATP synthase assembly protein;COG5387,Chaperone required for the assembly of the mitochondrial F1-ATPase","GO:0005829,cellular_component,cytosol;GO:0043461,biological_process,proton-transporting ATP synthase complex assembly;GO:0016607,cellular_component,nuclear speck","-"]
["LINC00958",33.09549063,8.790970478,1.911096156,5.933781074,{"v":8.63e-13,"d":"8.63E-13"},{"v":1.6E-11,"d":"1.60E-11"},"ENSG00000251381","A0A1B0GTR1,Propionyl-CoA carboxylase alpha chain, mitochondrial","-","PF00289,Biotin carboxylase, N-terminal domain","IPR005481,Biotin carboxylase-like, N-terminal domain;IPR016185,Pre-ATP-grasp domain superfamily;IPR011764,Biotin carboxylation domain","-","-","-"]
["MAP4K5",11.65486802,3.096032552,1.910895807,5.838433753,1.79E-12,{"v":3.06e-11,"d":"3.06E-11"},"ENSG00000012983","A0A0A0MQR1,Mitogen-activated protein kinase kinase kinase kinase","-","PF00069,Protein kinase domain;PF00780,CNH domain","-","-","-","-"]
["ZBTB7B",20.91503487,5.558780267,1.910177247,5.85742003,{"v":1.96e-12,"d":"1.96E-12"},{"v":3.3e-11,"d":"3.30E-11"},"ENSG00000160685","H2Q062,Uncharacterized protein","XP_016783812.1,-;XP_003308469.1,-;XP_009431248.1,-","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:2000320,biological_process,negative regulation of T-helper 17 cell differentiation;GO:0043370,biological_process,regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043376,biological_process,regulation of CD8-positive, alpha-beta T cell differentiation;GO:0003676,molecular_function,nucleic acid binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0010629,biological_process,negative regulation of gene expression;GO:0010628,biological_process,positive regulation of gene expression;GO:0010468,biological_process,regulation of gene expression;GO:0003677,molecular_function,DNA binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["RALGPS1",1.649813515,0.436593531,1.910017405,3.565638386,{"v":1.94e-05,"d":"1.94E-05"},{"v":6.91e-05,"d":"6.91E-05"},"ENSG00000136828","F6TUP7,Ral GEF with PH domain and SH3 binding motif 1","XP_014972295.1,-","PF00617,RasGEF domain;PF00169,PH domain","IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR011993,PH-like domain superfamily;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR001849,Pleckstrin homology domain;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily","ENOG410IQ6R,-;ENOG410YV9P,-","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005622,cellular_component,intracellular","-"]
["RAP1GAP2",5.077169109,1.348946454,1.908609028,4.652831632,{"v":9.11e-09,"d":"9.11E-09"},{"v":6.77e-08,"d":"6.77E-08"},"ENSG00000132359","A0A1B0GV05,Rap1 GTPase-activating protein 2","XP_011522040.1,rap1 GTPase-activating protein 2 isoform X1","PF02145,Rap/ran-GAP","IPR035974,Rap/Ran-GAP superfamily;IPR000331,Rap GTPase activating protein domain","-","GO:0031965,cellular_component,nuclear membrane;GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0005829,cellular_component,cytosol","-"]
["NALCN",1.246858097,0.329457156,1.907835462,2.978056107,0.000212314,0.000598384,"ENSG00000102452","H2Q7R6,Sodium leak channel, non-selective","XP_001149573.1,-","PF00520,Ion transport protein","IPR005821,Ion transport domain;IPR028823,Sodium leak channel non-selective protein;IPR027359,Voltage-dependent channel domain superfamily","KOG2301,Voltage-gated Ca2+ channels, alpha1 subunits;ENOG410XNP6,-","GO:0005216,molecular_function,ion channel activity;GO:0098655,biological_process,cation transmembrane transport;GO:0055085,biological_process,transmembrane transport;GO:0086010,biological_process,membrane depolarization during action potential;GO:0006811,biological_process,ion transport;GO:0005261,molecular_function,cation channel activity;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0034220,biological_process,ion transmembrane transport;GO:0006816,biological_process,calcium ion transport;GO:0016021,cellular_component,integral component of membrane","-"]
["ST6GALNAC1",3.236840727,0.855270013,1.907835462,2.978056107,0.000212314,0.000598384,"ENSG00000070526","G3QCR6,ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1","XP_004040951.2,alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1","PF00777,lycosyltransferase family 29 (sialyltransferase)","IPR038578,GT29-like superfamiliy;IPR001675,Glycosyl transferase family 29","-","GO:0008373,molecular_function,sialyltransferase activity;GO:0006486,biological_process,protein glycosylation;GO:0097503,biological_process,sialylation","-"]
["FZD7",2.89210335,0.7641801,1.907835462,2.978056107,0.000212314,0.000598384,"ENSG00000155760","H2QJ90,Uncharacterized protein","-","PF01392,z domain;PF01534,rizzled/Smoothened family membrane region","-","-","-","-"]
["POC5",3.236840727,0.855270013,1.907835462,2.978056107,0.000212314,0.000598384,"ENSG00000152359","H2QR38,POC5 centriolar protein homolog","XP_001147458.1,centrosomal protein POC5 isoform X1","-","IPR033351,Centrosomal protein POC5","ENOG410XRU9,-;ENOG410IF7G,-","GO:0005829,cellular_component,cytosol;GO:0005813,cellular_component,centrosome;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["LRRC8C",1.579826965,0.419221399,1.90659259,3.655956758,{"v":8.25e-06,"d":"8.25E-06"},{"v":3.2e-05,"d":"3.20E-05"},"ENSG00000171488","H2PZD4,Leucine rich repeat containing 8 family member C","XP_016777645.1,-;XP_016777654.1,-","PF13855,Leucine rich repeat;PF12534,Pannexin-like TM region of LRRC8","IPR001611,Leucine-rich repeat;IPR021040,LRRC8, pannexin-like TM region;IPR026906,Leucine rich repeat 5;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0005225,molecular_function,volume-sensitive anion channel activity;GO:0034702,cellular_component,ion channel complex;GO:0005737,cellular_component,cytoplasm;GO:0098656,biological_process,anion transmembrane transport;GO:0005783,cellular_component,endoplasmic reticulum;GO:0015698,biological_process,inorganic anion transport;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0045444,biological_process,fat cell differentiation","-"]
["BTN3A2",6.811552023,1.814665487,1.905434087,4.970508082,{"v":1.19E-9,"d":"1.19E-09"},{"v":1.08e-08,"d":"1.08E-08"},"ENSG00000186470","A0A024QZZ1,Butyrophilin, subfamily 3, member A2, isoform CRA_a","-","PF07686,Immunoglobulin V-set domain","IPR003599,Immunoglobulin subtype;IPR013783,Immunoglobulin-like fold;IPR036179,Immunoglobulin-like domain superfamily;IPR013106,Immunoglobulin V-set domain;IPR007110,Immunoglobulin-like domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["WIZ",6.171280612,1.645516359,1.904255588,5.005023351,{"v":7.5E-10,"d":"7.50E-10"},{"v":7.08e-09,"d":"7.08E-09"},"ENSG00000011451","M0QXA7,Protein Wiz","XP_005260067.1,-;XP_005260066.1,protein Wiz isoform X7;XP_011526465.1,-","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0030496,cellular_component,midbody;GO:0003676,molecular_function,nucleic acid binding;GO:0005654,cellular_component,nucleoplasm","-"]
["TUBGCP4",2.423279613,0.645295479,1.90388996,4.175357122,{"v":2.29E-7,"d":"2.29E-07"},{"v":1.24E-6,"d":"1.24E-06"},"ENSG00000137822","G3QK70,Gamma-tubulin complex component","-","PF04130,Spc97 / Spc98 family","IPR007259,Gamma-tubulin complex component protein","-","GO:0005874,cellular_component,microtubule;GO:0007020,biological_process,microtubule nucleation;GO:0005737,cellular_component,cytoplasm;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0005813,cellular_component,centrosome;GO:0043015,molecular_function,gamma-tubulin binding;GO:0005856,cellular_component,cytoskeleton;GO:0005815,cellular_component,microtubule organizing center;GO:0000922,cellular_component,spindle pole;GO:0055037,cellular_component,recycling endosome","-"]
["RP11-490O6.2",4.754689085,1.261699827,1.902922106,3.112549245,2.18753E-4,0.000613202,"ENSG00000262420","Q9H6X1,cDNA: FLJ21777 fis, clone HEP00173","-","-","-","-","-","-"]
["TMEM214",13.49315286,3.603630557,1.902650026,5.425381182,{"v":4.57e-11,"d":"4.57E-11"},{"v":5.63e-10,"d":"5.63E-10"},"ENSG00000119777","H2QHL1,Transmembrane protein 214","XP_016803708.1,transmembrane protein 214 isoform X4","PF10151,TMEM214, C-terminal, caspase 4 activator","IPR019308,Transmembrane protein 214","ENOG410ZR2A,-;KOG4467,Uncharacterized conserved protein","GO:0005829,cellular_component,cytosol;GO:0005794,cellular_component,Golgi apparatus;GO:0005881,cellular_component,cytoplasmic microtubule;GO:0016021,cellular_component,integral component of membrane;GO:0005783,cellular_component,endoplasmic reticulum","-"]
["PDGFD",8.349512844,2.227435515,1.90248534,4.555520986,{"v":2.26e-08,"d":"2.26E-08"},{"v":1.54E-7,"d":"1.54E-07"},"ENSG00000170962","H2Q4N6,Platelet derived growth factor D","-","PF00431,CUB domain;PF00341,PDGF/VEGF domain","IPR000859,CUB domain;IPR035914,Spermadhesin, CUB domain superfamily;IPR000072,PDGF/VEGF domain;IPR027123,Platelet-derived growth factor D;IPR029034,Cystine-knot cytokine","ENOG410IGUN,-;ENOG41106HA,-","GO:0008083,molecular_function,growth factor activity;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0048008,biological_process,platelet-derived growth factor receptor signaling pathway;GO:0005161,molecular_function,platelet-derived growth factor receptor binding;GO:0043406,biological_process,positive regulation of MAP kinase activity;GO:0007596,biological_process,blood coagulation;GO:0016020,cellular_component,membrane;GO:0031954,biological_process,positive regulation of protein autophosphorylation;GO:0030335,biological_process,positive regulation of cell migration;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0005615,cellular_component,extracellular space","-"]
["RAVER1",10.58344755,2.828654515,1.90104329,5.103859529,{"v":5.47e-10,"d":"5.47E-10"},{"v":5.37e-09,"d":"5.37E-09"},"ENSG00000161847","K7DLH7,Ribonucleoprotein, PTB-binding 1","XP_016790472.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034633,Ribonucleoprotein PTB-binding 1, RNA recognition motif 1;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034635,Ribonucleoprotein PTB-binding 1;IPR035979,RNA-binding domain superfamily;IPR000504,RNA recognition motif domain","ENOG410ZP6I,-;ENOG410IJBP,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0030529,,","-"]
["NCKAP1",19.99220406,5.35435825,1.900350481,8.162198279,{"v":2.67e-17,"d":"2.67E-17"},1.31E-15,"ENSG00000061676","F7BW72,NCK associated protein 1","XP_014965990.1,-","PF09735,Membrane-associated apoptosis protein","IPR019137,Nck-associated protein 1","KOG1917,Membrane-associated hematopoietic protein;ENOG410XPQI,-","GO:0031209,cellular_component,SCAR complex;GO:2000601,biological_process,positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0044877,molecular_function,protein-containing complex binding;GO:0010592,biological_process,positive regulation of lamellipodium assembly;GO:0016601,biological_process,Rac protein signal transduction;GO:0048365,molecular_function,Rac GTPase binding","-"]
["FLJ37035",1.452990399,0.381892127,1.900313002,1.953618186,0.01534811,0.027975664,"ENSG00000224023","Q8N9J6,cDNA FLJ37035 fis, clone BRACE2011545","-","-","-","-","-","-"]
["RP11-328C8.4",1.786694035,0.469600065,1.900313002,1.953618186,0.01534811,0.027975664,"ENSG00000257225","H2Q5R0,Prickle homolog 1","-","PF06297,PET Domain;PF00412,LIM domain","IPR033723,PET prickle;IPR033726,LIM2 prickle;IPR001781,Zinc finger, LIM-type;IPR033727,LIM3 prickle;IPR010442,PET domain","KOG1704,FOG: LIM domain;ENOG410XP0W,-","GO:0008270,molecular_function,zinc ion binding","-"]
["RP11-74E22.5",7.965915417,2.093696135,1.900313002,1.953618186,0.01534811,0.027975664,"-","-","-","-","-","-","-","-"]
["SHISA5",16.80142537,4.496239384,1.900060382,5.663240936,{"v":8.66e-12,"d":"8.66E-12"},1.26E-10,"ENSG00000164054","K7AV59,Shisa homolog 5","-","PF13908,Wnt and FGF inhibitory regulator","IPR026910,Shisa family","ENOG410YNKU,-;ENOG410J1CW,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TPD52",46.81415088,12.5517045,1.89870823,7.932911836,{"v":5.99e-17,"d":"5.99E-17"},2.77E-15,"ENSG00000076554","H0XFQ6,Tumor protein D52","XP_012665925.1,tumor protein D52 isoform X1","PF04201,Tumour protein D52 family","IPR007327,Tumour protein D52","ENOG4111M9H,-;KOG4010,Coiled-coil protein TPD52","-","-"]
["FAM179B",2.149483503,0.574064825,1.898556258,3.896934928,{"v":2.46e-06,"d":"2.46E-06"},{"v":1.07e-05,"d":"1.07E-05"},"ENSG00000198718","G3XAE9,KIAA0423, isoform CRA_a","NP_001295049.1,TOG array regulator of axonemal microtubules protein 1 isoform 1","PF12348,CLASP N terminal","IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR028401,Crescerin-1;IPR024395,CLASP N-terminal domain;IPR034085,TOG domain","KOG2933,Uncharacterized conserved protein;ENOG410XSBP,-","GO:0005874,cellular_component,microtubule;GO:0036064,cellular_component,ciliary basal body;GO:0031116,biological_process,positive regulation of microtubule polymerization;GO:0005929,cellular_component,cilium","-"]
["COMMD2",13.46947978,3.61024812,1.897472482,5.421352836,{"v":5.35e-11,"d":"5.35E-11"},{"v":6.48e-10,"d":"6.48E-10"},"ENSG00000114744","H2PBQ6,COMM domain-containing protein 2","-","PF07258,COMM domain","IPR037354,COMM domain-containing protein 2;IPR017920,COMM domain","ENOG410IKFK,-;ENOG410XTIB,-","-","-"]
["ROR1",3.465538978,0.927119204,1.896430858,3.968993922,{"v":1.51e-06,"d":"1.51E-06"},{"v":6.91e-06,"d":"6.91E-06"},"ENSG00000185483","K7CHI3,Receptor tyrosine kinase-like orphan receptor 1","XP_016775314.1,-","PF01392,z domain;PF00051,Kringle domain;PF07714,Protein tyrosine kinase;PF07679,Immunoglobulin I-set domain","IPR000719,Protein kinase domain;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR000001,Kringle;IPR036790,Frizzled cysteine-rich domain superfamily;IPR038178,Kringle superfamily;IPR020067,Frizzled domain;IPR013806,Kringle-like fold;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR008266,Tyrosine-protein kinase, active site;IPR007110,Immunoglobulin-like domain;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set;IPR018056,Kringle, conserved site;IPR011009,Protein kinase-like domain superfamily;IPR016247,Tyrosine-protein kinase, receptor ROR","COG0515,Serine/threonine protein kinase;ENOG410IMMJ,-","GO:0016301,molecular_function,kinase activity;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016310,biological_process,phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","-"]
["SLC1A6",1.925520404,0.514250764,1.895499088,3.348412295,{"v":4.43e-05,"d":"4.43E-05"},0.000145626,"ENSG00000105143","U3EGZ4,Amino acid transporter","XP_017823663.1,-","PF00375,Sodium:dicarboxylate symporter family","IPR001991,Sodium:dicarboxylate symporter;IPR018107,Sodium:dicarboxylate symporter, conserved site;IPR036458,Sodium:dicarboxylate symporter superfamily","-","GO:0055085,biological_process,transmembrane transport;GO:0015293,molecular_function,symporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K05617,ko04724,Glutamatergic synapse"]
["ZDHHC2",2.185973127,0.583810147,1.895499088,3.348412295,{"v":4.43e-05,"d":"4.43E-05"},0.000145626,"ENSG00000104219","G3RL61,Palmitoyltransferase","XP_004046739.1,-","PF01529,HHC palmitoyltransferase","IPR001594,Palmitoyltransferase, DHHC domain","-","GO:0005794,cellular_component,Golgi apparatus;GO:0016409,molecular_function,palmitoyltransferase activity;GO:0019706,molecular_function,protein-cysteine S-palmitoyltransferase activity;GO:0055038,cellular_component,recycling endosome membrane;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0018345,biological_process,protein palmitoylation;GO:0016020,cellular_component,membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["RUBCN",10.33873847,2.777131254,1.894875877,5.845472365,3.27E-12,{"v":5.24e-11,"d":"5.24E-11"},"ENSG00000145016","K7BBI5,KIAA0226","-","PF13901,Putative zinc-RING and/or ribbon;PF02759,RUN domain","IPR004012,RUN domain;IPR025258,Putative zinc-RING and/or ribbon;IPR037213,RUN domain superfamily","KOG4381,RUN domain-containing protein;ENOG410XQ7T,-;KOG1829,Uncharacterized conserved protein, contains C1, PH and RUN domains","-","-"]
["RNF217",2.768726946,0.743582433,1.892844518,4.548094406,{"v":2.83e-08,"d":"2.83E-08"},{"v":1.89e-07,"d":"1.89E-07"},"ENSG00000146373","F7DGD2,Ring finger protein 217","XP_001107488.1,probable E3 ubiquitin-protein ligase RNF217","PF01485,IBR domain, a half RING-finger domain","IPR002867,IBR domain;IPR031127,E3 ubiquitin ligase RBR family;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XP9Y,-;KOG1815,Predicted E3 ubiquitin ligase","GO:0000209,biological_process,protein polyubiquitination;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0031624,molecular_function,ubiquitin conjugating enzyme binding;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0032436,biological_process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016020,cellular_component,membrane;GO:0000151,cellular_component,ubiquitin ligase complex;GO:0016021,cellular_component,integral component of membrane","-"]
["RP11-388P9.2",3.839529712,1.018853996,1.892006694,2.218886875,4.295849E-3,0.008967843,"ENSG00000232682","A0A087WZ65,Ankyrin-3","-","PF00531,eath domain","IPR037971,Ankyrin-3, death domain;IPR000488,Death domain;IPR000906,ZU5 domain;IPR011029,Death-like domain superfamily","COG0666,FOG: Ankyrin repeat;KOG4177,Ankyrin","GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction","-"]
["NAGPA",1.125813964,0.298744935,1.892006694,2.218886875,4.295849E-3,0.008967843,"ENSG00000103174","H2QAJ1,N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase","XP_510795.2,N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1","PF09992,Phosphodiester glycosidase","IPR013032,EGF-like, conserved site;IPR018711,Phosphodiester glycosidase;IPR000742,EGF-like domain","ENOG410IF19,-;ENOG410ZT6Y,-","GO:0033299,biological_process,secretion of lysosomal enzymes;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["C19orf66",1.422244593,0.377405488,1.892006694,2.218886875,4.295849E-3,0.008967843,"ENSG00000130813","H2NXI0,Chromosome 19 open reading frame 66","XP_002828690.1,-","PF15135,Uncharacterised protein UPF0515","IPR026795,Repressor of yield of DENV protein","ENOG410IPDV,-;ENOG4110MZD,-","GO:0051607,biological_process,defense response to virus;GO:0034341,biological_process,response to interferon-gamma;GO:0034342,biological_process,response to type III interferon;GO:0034340,biological_process,response to type I interferon;GO:0003723,molecular_function,RNA binding;GO:0005737,cellular_component,cytoplasm;GO:0045071,biological_process,negative regulation of viral genome replication;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["ZNF341",1.131384236,0.300223058,1.892006694,2.218886875,4.295849E-3,0.008967843,"ENSG00000131061","H2QK74,Uncharacterized protein","XP_003316912.1,zinc finger protein 341 isoform X2","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["GS1-358P8.4",1.247013488,0.330906327,1.892006694,2.218886875,4.295849E-3,0.008967843,"-","-","-","-","-","-","-","-"]
["RP11-275I14.4",31.9572532,8.574370525,1.890157556,3.550625125,{"v":2.62E-5,"d":"2.62E-05"},{"v":9.07e-05,"d":"9.07E-05"},"ENSG00000234478","H2N3J4,Uncharacterized protein","-","-","-","-","-","-"]
["ITGB8",1.927131029,0.518865313,1.888420954,4.283156151,{"v":2.27e-07,"d":"2.27E-07"},{"v":1.23e-06,"d":"1.23E-06"},"ENSG00000105855","H2QU86,Integrin beta","XP_518987.2,integrin beta-8 isoform X1;XP_016801012.1,-","PF00362,Integrin beta chain VWA domain;PF17205,Integrin plexin domain;PF07974,-like domain","IPR015812,Integrin beta subunit;IPR036465,von Willebrand factor A-like domain superfamily;IPR002369,Integrin beta subunit, VWA domain;IPR016201,PSI domain;IPR032695,Integrin domain superfamily;IPR013111,EGF-like domain, extracellular;IPR013032,EGF-like, conserved site;IPR015442,Integrin beta-8 subunit;IPR033760,Integrin beta N-terminal","KOG1226,Integrin beta subunit (N-terminal portion of extracellular region);ENOG410XP60,-","GO:0008305,cellular_component,integrin complex;GO:0007155,biological_process,cell adhesion;GO:0007160,biological_process,cell-matrix adhesion;GO:0004872,-,-;GO:0016020,cellular_component,membrane;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0016021,cellular_component,integral component of membrane","K06591,ko05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);K06591,ko05410,Hypertrophic cardiomyopathy (HCM);K06591,ko04514,Cell adhesion molecules (CAMs);K06591,ko05414,Dilated cardiomyopathy;K06591,ko04810,Regulation of actin cytoskeleton;K06591,ko04512,ECM-receptor interaction;K06591,ko04151,PI3K-Akt signaling pathway;K06591,ko04510,Focal adhesion"]
["MAPK3",20.84005636,5.626273382,1.887353334,5.63107936,1.58E-11,2.18E-10,"ENSG00000102882","K7CQE8,Mitogen-activated protein kinase","-","PF00069,Protein kinase domain","-","-","-","-"]
["RAB14",40.27553579,10.88658751,1.886579005,6.796233853,9.66E-15,{"v":2.78e-13,"d":"2.78E-13"},"ENSG00000119396","A0A091N1W1,Ras-related protein Rab-14","XP_009877698.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR030702,Ras-related protein Rab14;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0045335,cellular_component,phagocytic vesicle;GO:0005525,molecular_function,GTP binding;GO:0090382,biological_process,phagosome maturation;GO:0005802,cellular_component,trans-Golgi network;GO:0055037,cellular_component,recycling endosome;GO:0003924,molecular_function,GTPase activity;GO:0005829,cellular_component,cytosol;GO:0032456,biological_process,endocytic recycling;GO:0042742,biological_process,defense response to bacterium;GO:0006895,biological_process,Golgi to endosome transport","-"]
["RP5-892K4.1",1.754352837,0.468536861,1.886394503,2.441977045,0.004015236,0.008447797,"ENSG00000271806","I7G8L2,Macaca fascicularis brain cDNA clone: QmoA-11833, similar to human chemokine","-","-","-","-","-","-"]
["ELMO3",2.858743497,0.763487639,1.886394503,2.441977045,0.004015236,0.008447797,"ENSG00000102890","H2RBU5,Uncharacterized protein","XP_001162282.2,engulfment and cell motility protein 3","PF16457,Pleckstrin homology domain;PF11841,omain of unknown function (DUF3361);PF04727,LMO/CED-12 family","IPR024574,Domain of unknown function DUF3361;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR006816,ELMO domain;IPR016024,Armadillo-type fold;IPR030719,Engulfment and cell motility protein 3","ENOG410XPKN,-;KOG2999,Regulator of Rac1, required for phagocytosis and cell migration","GO:0016477,biological_process,cell migration","-"]
["RP1-152L7.5",2.422265385,0.64691697,1.886394503,2.441977045,0.004015236,0.008447797,"ENSG00000216775","H3AJJ3,Uncharacterized protein","-","PF05699,hAT family C-terminal dimerisation region","IPR008906,HAT, C-terminal dimerisation domain;IPR012337,Ribonuclease H-like superfamily","COG2801,Transposase and inactivated derivatives;ENOG410JFV0,-","GO:0046983,molecular_function,protein dimerization activity","-"]
["C3orf58",3.548702736,0.955461112,1.886129637,3.727644025,{"v":6.48e-06,"d":"6.48E-06"},{"v":2.57e-05,"d":"2.57E-05"},"ENSG00000181744","F7HNR0,Chromosome 3 open reading frame 58","NP_001247970.1,-","PF12260,Protein-kinase domain of FAM69","IPR020519,Uncharacterised protein family UPF0672;IPR022049,FAM69, protein-kinase domain","ENOG410XR52,-;ENOG410IKM0,-","GO:0060038,biological_process,cardiac muscle cell proliferation;GO:0030126,cellular_component,COPI vesicle coat;GO:0000139,cellular_component,Golgi membrane;GO:0014066,biological_process,regulation of phosphatidylinositol 3-kinase signaling;GO:0030137,cellular_component,COPI-coated vesicle;GO:0005615,cellular_component,extracellular space","-"]
["STIM1",6.128003749,1.654401686,1.886040053,4.843662011,{"v":3.13e-09,"d":"3.13E-09"},{"v":2.56e-08,"d":"2.56E-08"},"ENSG00000167323","G0XQ39,STIM1L","NP_001264890.1,stromal interaction molecule 1 isoform 1 precursor;NP_001264891.1,stromal interaction molecule 1 isoform 3 precursor","PF16533,STIM1 Orai1-activating region;PF07647,SAM domain (Sterile alpha motif)","IPR030463,Stromal interaction molecule 1;IPR037608,Stromal interaction molecule;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR032393,Stromal interaction molecule, Orai1-activating region;IPR037609,Stromal interaction molecule 1, SAM domain;IPR001660,Sterile alpha motif domain","KOG4403,Cell surface glycoprotein STIM, contains SAM domain;ENOG410XRM6,-","GO:0015279,molecular_function,store-operated calcium channel activity;GO:0051924,biological_process,regulation of calcium ion transport;GO:2001256,biological_process,regulation of store-operated calcium entry;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0030426,cellular_component,growth cone;GO:0005783,cellular_component,endoplasmic reticulum;GO:0002115,biological_process,store-operated calcium entry;GO:0006812,biological_process,cation transport;GO:0014902,biological_process,myotube differentiation;GO:0005886,cellular_component,plasma membrane;GO:0032237,biological_process,activation of store-operated calcium channel activity;GO:0005246,molecular_function,calcium channel regulator activity;GO:0016020,cellular_component,membrane;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0070588,biological_process,calcium ion transmembrane transport","-"]
["KIAA0586",3.217743524,0.868707091,1.88502005,4.443117869,{"v":9.38e-08,"d":"9.38E-08"},{"v":5.54e-07,"d":"5.54E-07"},"ENSG00000100578","H2Q8D9,Uncharacterized protein","-","PF15324,Hedgehog signalling target","IPR029246,Protein TALPID3","ENOG4112DEQ,-;ENOG410IHSG,-","GO:0007224,biological_process,smoothened signaling pathway;GO:0005814,cellular_component,centriole;GO:0070201,biological_process,regulation of establishment of protein localization;GO:0036064,cellular_component,ciliary basal body;GO:0005813,cellular_component,centrosome;GO:0060271,biological_process,cilium assembly","-"]
["RP11-597D13.9",6.021777048,1.626986427,1.884046282,4.492702004,{"v":5.12e-08,"d":"5.12E-08"},{"v":3.21e-07,"d":"3.21E-07"},"ENSG00000248429","H2QQC7,Uncharacterized protein","-","PF15051,AM198 protein","-","-","-","-"]
["PIP5K1C",6.957040017,1.882311906,1.883208818,4.988729524,{"v":1.32E-9,"d":"1.32E-09"},{"v":1.18E-8,"d":"1.18E-08"},"ENSG00000186111","K7CA55,Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma","XP_016792550.1,phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X4","PF01504,Phosphatidylinositol-4-phosphate 5-Kinase","IPR023610,Phosphatidylinositol-4-phosphate 5-kinase;IPR002498,Phosphatidylinositol-4-phosphate 5-kinase, core;IPR027484,Phosphatidylinositol-4-phosphate 5-kinase, N-terminal;IPR027483,Phosphatidylinositol-4-phosphate 5-kinase, C-terminal","COG5253,Phosphatidylinositol-4-phosphate 5-kinase;KOG0229,Phosphatidylinositol-4-phosphate 5-kinase","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0016307,molecular_function,phosphatidylinositol phosphate kinase activity;GO:0000166,molecular_function,nucleotide binding;GO:0046488,biological_process,phosphatidylinositol metabolic process;GO:0046854,biological_process,phosphatidylinositol phosphorylation","-"]
["STAM",15.2893316,4.138694162,1.882586363,5.022818364,{"v":1.01E-9,"d":"1.01E-09"},{"v":9.25e-09,"d":"9.25E-09"},"ENSG00000136738","G3QDI4,Signal transducing adaptor molecule","XP_018890987.1,-","PF02809,Ubiquitin interaction motif;PF00018,SH3 domain;PF00790,VHS domain","IPR008942,ENTH/VHS;IPR002014,VHS domain;IPR003903,Ubiquitin interacting motif;IPR036028,SH3-like domain superfamily;IPR035657,STAM1, SH3 domain;IPR001452,SH3 domain","-","GO:1903543,biological_process,positive regulation of exosomal secretion;GO:1903551,biological_process,regulation of extracellular exosome assembly;GO:0033565,cellular_component,ESCRT-0 complex;GO:0044389,molecular_function,ubiquitin-like protein ligase binding;GO:0006886,biological_process,intracellular protein transport","K04705,ko04630,Jak-STAT signaling pathway;K04705,ko04144,Endocytosis"]
["DNAJC24",1.125996474,0.302113292,1.882348566,2.634516514,0.001847602,0.004210344,"ENSG00000170946","H2Q3C7,DnaJ","XP_001141859.1,-","PF05207,CSL zinc finger;PF00226,naJ domain","IPR007872,Zinc finger, DPH-type;IPR036869,Chaperone J-domain superfamily;IPR036671,DPH Zinc finger superfamily;IPR001623,DnaJ domain","KOG0715,Molecular chaperone (DnaJ superfamily);COG0484,DnaJ-class molecular chaperone with C-terminal Zn finger domain","GO:0046872,molecular_function,metal ion binding","-"]
["ZNF138",2.999496572,0.804787409,1.882348566,2.634516514,0.001847602,0.004210344,"ENSG00000197008","J3QSS9,Zinc finger protein 138","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TRIM2",3.980764239,1.07772592,1.881497539,4.631928401,{"v":1.75e-08,"d":"1.75E-08"},{"v":1.22e-07,"d":"1.22E-07"},"ENSG00000109654","G3QWJ0,Tripartite motif containing 2","-","PF01436,NHL repeat;PF00630,ilamin/ABP280 repeat;PF00643,B-box zinc finger;PF13445,RING-type zinc-finger","IPR001258,NHL repeat;IPR017907,Zinc finger, RING-type, conserved site;IPR011042,Six-bladed beta-propeller, TolB-like;IPR000315,B-box-type zinc finger;IPR003649,B-box, C-terminal;IPR014756,Immunoglobulin E-set;IPR001298,Filamin/ABP280 repeat;IPR001841,Zinc finger, RING-type;IPR017868,Filamin/ABP280 repeat-like;IPR013017,NHL repeat, subgroup;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR027370,RING-type zinc-finger, LisH dimerisation motif;IPR013783,Immunoglobulin-like fold","-","GO:0005737,cellular_component,cytoplasm;GO:0046872,molecular_function,metal ion binding;GO:0008270,molecular_function,zinc ion binding;GO:0005622,cellular_component,intracellular","-"]
["MSL1",12.90509374,3.499447365,1.88134461,5.946937334,2.18E-12,{"v":3.62e-11,"d":"3.62E-11"},"ENSG00000188895","H2QCV9,Uncharacterized protein","XP_009430508.1,-","PF15275,PEHE domain;PF16801,imerisation domain of Male-specific-Lethal 1","IPR031840,Protein male-specific lethal-1, dimerisation domain;IPR026711,Protein male-specific lethal-1;IPR029332,PEHE domain","ENOG410XPFF,-;ENOG410IDXY,-","GO:0043984,biological_process,histone H4-K16 acetylation;GO:0072487,cellular_component,MSL complex","-"]
["COMMD3-BMI1",21.57594807,5.851132948,1.879393799,4.758831296,{"v":8.77e-09,"d":"8.77E-09"},{"v":6.53e-08,"d":"6.53E-08"},"ENSG00000269897","R4GMX3,COMMD3-BMI1 readthrough","NP_001190991.1,COMMD3-BMI1 read-through protein","PF16207,RAWUL domain RING finger- and  WD40-associated ubiquitin-like;PF13923,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR032443,RAWUL domain;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XPCN,-;KOG2660,Locus-specific chromosome binding proteins","GO:0005829,cellular_component,cytosol;GO:0016604,cellular_component,nuclear body","K11459,ko04550,Signaling pathways regulating pluripotency of stem cells;K11459,ko05202,Transcriptional misregulation in cancer;K11459,ko05206,MicroRNAs in cancer"]
["ZNF180",2.035514522,0.548046741,1.879293494,2.803903635,0.000612799,0.001551082,"ENSG00000167384","H2QGJ8,Zinc finger protein 180","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TICAM2",3.001191725,0.808047953,1.879293494,2.803903635,0.000612799,0.001551082,"ENSG00000243414","B3Y699,TIR domain-containing adaptor molecule 2","NP_001182133.1,TIR domain-containing adapter molecule 2","PF13676,TIR domain","IPR015720,TMP21-related;IPR035897,Toll/interleukin-1 receptor homology (TIR) domain superfamily;IPR000157,Toll/interleukin-1 receptor homology (TIR) domain","KOG1693,emp24/gp25L/p24 family of membrane trafficking proteins;ENOG4111JPD,-","GO:0051607,biological_process,defense response to virus;GO:0035669,biological_process,TRAM-dependent toll-like receptor 4 signaling pathway;GO:0034145,biological_process,positive regulation of toll-like receptor 4 signaling pathway;GO:2000494,biological_process,positive regulation of interleukin-18-mediated signaling pathway;GO:0070671,biological_process,response to interleukin-12;GO:0005768,cellular_component,endosome;GO:0032729,biological_process,positive regulation of interferon-gamma production;GO:0001817,biological_process,regulation of cytokine production;GO:0071651,biological_process,positive regulation of chemokine (C-C motif) ligand 5 production;GO:0032755,biological_process,positive regulation of interleukin-6 production;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0005886,cellular_component,plasma membrane;GO:0005543,molecular_function,phospholipid binding;GO:0007165,biological_process,signal transduction","K05409,ko04064,NF-kappa B signaling pathway;K05409,ko05161,Hepatitis B;K05409,ko05133,Pertussis;K05409,ko04620,Toll-like receptor signaling pathway"]
["MAN1A1",1.94173633,0.522797679,1.879293494,2.803903635,0.000612799,0.001551082,"ENSG00000111885","H2PK77,alpha-1,2-Mannosidase","-","PF01532,lycosyl hydrolase family 47","IPR012341,Six-hairpin glycosidase-like superfamily;IPR036026,Seven-hairpin glycosidases;IPR001382,Glycoside hydrolase family 47","ENOG410XP04,-;KOG2431,1, 2-alpha-mannosidase","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0016787,molecular_function,hydrolase activity;GO:0004571,molecular_function,mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0003824,molecular_function,catalytic activity;GO:0005509,molecular_function,calcium ion binding;GO:0000139,cellular_component,Golgi membrane;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["UBA1",9.554478426,2.596059608,1.877692251,5.325485487,1.26E-10,{"v":1.4e-09,"d":"1.40E-09"},"ENSG00000130985","A0A024R1A3,Testicular secretory protein Li 63","XP_016885270.1,-;NP_003325.2,ubiquitin-like modifier-activating enzyme 1;NP_695012.1,-;XP_016885269.1,-","PF16191,Ubiquitin-activating enzyme E1 four-helix bundle;PF16190,Ubiquitin-activating enzyme E1 FCCH domain;PF00899,ThiF family;PF09358,Ubiquitin fold domain;PF10585,Ubiquitin-activating enzyme active site","IPR032420,Ubiquitin-activating enzyme E1, four-helix bundle;IPR018074,Ubiquitin-activating enzyme E1, conserved site;IPR033127,Ubiquitin-activating enzyme E1, Cys active site;IPR000594,THIF-type NAD/FAD binding fold;IPR032418,Ubiquitin-activating enzyme E1, FCCH domain;IPR018075,Ubiquitin-activating enzyme E1;IPR018965,Ubiquitin-activating enzyme E1, C-terminal;IPR019572,Ubiquitin-activating enzyme, catalytic cysteine domain;IPR035985,Ubiquitin-activating enzyme;IPR000011,Ubiquitin/SUMO-activating enzyme E1;IPR038252,Ubiquitin-activating enzyme E1, C-terminal domain superfamily","COG0476,Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2;KOG2012,Ubiquitin activating enzyme UBA1","GO:0004839,molecular_function,ubiquitin activating enzyme activity;GO:0016567,biological_process,protein ubiquitination;GO:0016874,molecular_function,ligase activity;GO:0005654,cellular_component,nucleoplasm;GO:0005829,cellular_component,cytosol;GO:0008641,molecular_function,ubiquitin-like modifier activating enzyme activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0006464,biological_process,cellular protein modification process","K03178,ko05012,Parkinson's disease;K03178,ko04120,Ubiquitin mediated proteolysis"]
["DVL3",72.75872432,19.79969586,1.877342277,8.144122478,{"v":6.15e-17,"d":"6.15E-17"},{"v":2.81e-15,"d":"2.81E-15"},"ENSG00000161202","A0A0D9RM79,Dishevelled segment polarity protein 3","XP_007970124.1,-","PF02377,ishevelled specific domain;PF00610,omain found in Dishevelled, Egl-10, and Pleckstrin (DEP);PF00595,PDZ domain (Also known as DHR or GLGF);PF00778,IX domain;PF12316,Segment polarity protein dishevelled (Dsh) C terminal","IPR008342,Dishevelled-3;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR001158,DIX domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR024580,Dishevelled C-terminal;IPR038207,DIX domain superfamily;IPR015506,Dishevelled-related protein;IPR000591,DEP domain;IPR003351,Dishevelled protein domain;IPR029071,Ubiquitin-like domain superfamily;IPR036390,Winged helix DNA-binding domain superfamily;IPR008339,Dishevelled family","-","GO:0005109,molecular_function,frizzled binding;GO:0050821,biological_process,protein stabilization;GO:0035567,biological_process,non-canonical Wnt signaling pathway;GO:0035556,biological_process,intracellular signal transduction;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0016055,biological_process,Wnt signaling pathway;GO:0002020,molecular_function,protease binding;GO:0005102,molecular_function,signaling receptor binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0008013,molecular_function,beta-catenin binding;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0048365,molecular_function,Rac GTPase binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005829,cellular_component,cytosol;GO:0000790,cellular_component,nuclear chromatin;GO:0060071,biological_process,Wnt signaling pathway, planar cell polarity pathway;GO:0043507,biological_process,positive regulation of JUN kinase activity;GO:1903827,biological_process,regulation of cellular protein localization;GO:0001934,biological_process,positive regulation of protein phosphorylation","-"]
["ZFX",5.202734178,1.414061564,1.876600123,4.94820313,{"v":2.12e-09,"d":"2.12E-09"},{"v":1.82e-08,"d":"1.82E-08"},"ENSG00000005889","B7ZKJ5,ZFX protein","-","PF04704,Zfx / Zfy transcription activation region;PF00096,Zinc finger, C2H2 type;PF13909,C2H2-type zinc-finger domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR006794,Transcriptional activator, Zfx / Zfy domain","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding","-"]
["LA16c-431H6.6",16.49648024,4.491068624,1.875518086,5.830395533,{"v":5.45e-12,"d":"5.45E-12"},{"v":8.26e-11,"d":"8.26E-11"},"ENSG00000261732","J3QT63,Uncharacterized protein","-","-","-","-","GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["ANKRD40",35.69982386,9.730570446,1.874555438,6.796788567,{"v":1.67e-14,"d":"1.67E-14"},{"v":4.53e-13,"d":"4.53E-13"},"ENSG00000154945","A8IK34,Ankyrin repeat domain 40","NP_443087.1,ankyrin repeat domain-containing protein 40","PF13637,Ankyrin repeats (many copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","ENOG410IN88,-;ENOG410XSX1,-","-","-"]
["NCOR2",53.96589778,14.72433943,1.87366965,8.909987379,1.24E-17,{"v":6.57e-16,"d":"6.57E-16"},"ENSG00000196498","C9JFD3,Nuclear receptor corepressor 2","NP_006303.4,nuclear receptor corepressor 2 isoform 1","PF15784,-protein pathway suppressor 2-interacting domain;PF00249,Myb-like DNA-binding domain","IPR031557,N-CoR, GPS2-interacting domain;IPR009057,Homeobox-like domain superfamily;IPR001005,SANT/Myb domain;IPR017884,SANT domain","ENOG410YDXP,-;KOG1878,Nuclear receptor coregulator SMRT/SMRTER, contains Myb-like domains","GO:0003677,molecular_function,DNA binding;GO:0000785,cellular_component,chromatin;GO:0010243,biological_process,response to organonitrogen compound;GO:0044849,biological_process,estrous cycle;GO:0016922,molecular_function,ligand-dependent nuclear receptor binding;GO:0035259,molecular_function,glucocorticoid receptor binding;GO:0001012,molecular_function,RNA polymerase II regulatory region DNA binding;GO:0007595,biological_process,lactation;GO:0042974,molecular_function,retinoic acid receptor binding;GO:0005654,cellular_component,nucleoplasm;GO:0032355,biological_process,response to estradiol;GO:0005634,cellular_component,nucleus;GO:0046965,molecular_function,retinoid X receptor binding;GO:0003682,molecular_function,chromatin binding","K06065,ko05169,Epstein-Barr virus infection;K06065,ko04330,Notch signaling pathway"]
["CHD8",12.28451421,3.349999438,1.873506549,6.275850958,{"v":3.28e-13,"d":"3.28E-13"},{"v":6.67e-12,"d":"6.67E-12"},"ENSG00000100888","H2RDM3,Chromodomain-helicase-DNA-binding protein 8","XP_003314292.2,chromodomain-helicase-DNA-binding protein 8 isoform X2;XP_016781333.1,-","PF07533,BRK domain;PF00176,SNF2 family N-terminal domain;PF00385,Chromo (CHRromatin Organisation MOdifier) domain;PF00271,Helicase conserved C-terminal domain","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR023780,Chromo domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR016197,Chromo-like domain superfamily;IPR034724,Chromodomain-helicase-DNA-binding protein 8;IPR006576,BRK domain;IPR000953,Chromo/chromo shadow domain;IPR037259,BRK domain superfamily;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR001650,Helicase, C-terminal","COG0553,Superfamily II DNA/RNA helicases, SNF2 family;KOG0383,Predicted helicase","GO:0016055,biological_process,Wnt signaling pathway;GO:0042393,molecular_function,histone binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0032508,biological_process,DNA duplex unwinding;GO:0005634,cellular_component,nucleus;GO:0008013,molecular_function,beta-catenin binding;GO:0016787,molecular_function,hydrolase activity;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0016817,molecular_function,hydrolase activity, acting on acid anhydrides;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0005524,molecular_function,ATP binding;GO:0030178,biological_process,negative regulation of Wnt signaling pathway;GO:0071339,cellular_component,MLL1 complex;GO:0003678,molecular_function,DNA helicase activity;GO:0004386,molecular_function,helicase activity;GO:0003677,molecular_function,DNA binding;GO:0006325,biological_process,chromatin organization;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000166,molecular_function,nucleotide binding;GO:0008094,molecular_function,DNA-dependent ATPase activity;GO:0043044,biological_process,ATP-dependent chromatin remodeling;GO:0002039,molecular_function,p53 binding","-"]
["PRICKLE3",4.16335884,1.128458953,1.873411369,3.216341848,0.000114266,0.000341484,"ENSG00000012211","A0A024QYW5,LIM domain only 6, isoform CRA_a","NP_006141.2,prickle planar cell polarity protein 3 isoform 1","PF06297,PET Domain;PF00412,LIM domain","IPR033723,PET prickle;IPR033726,LIM2 prickle;IPR033727,LIM3 prickle;IPR033725,LIM1 prickle;IPR010442,PET domain;IPR001781,Zinc finger, LIM-type","KOG1704,FOG: LIM domain;ENOG410XP0W,-","GO:0008270,molecular_function,zinc ion binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0005813,cellular_component,centrosome","-"]
["PGAM1",39.76162869,10.84555796,1.872976961,6.044344071,{"v":1.34e-12,"d":"1.34E-12"},{"v":2.36e-11,"d":"2.36E-11"},"ENSG00000171314","I3NCB7,Phosphoglycerate mutase","XP_005335329.1,-","PF00300,Histidine phosphatase superfamily (branch 1)","IPR001345,Phosphoglycerate/bisphosphoglycerate mutase, active site;IPR005952,Phosphoglycerate mutase 1;IPR029033,Histidine phosphatase superfamily;IPR013078,Histidine phosphatase superfamily, clade-1","KOG0235,Phosphoglycerate mutase;COG0588,Phosphoglycerate mutase 1","GO:0043209,cellular_component,myelin sheath;GO:0006096,biological_process,glycolytic process;GO:0004619,molecular_function,phosphoglycerate mutase activity;GO:0016868,molecular_function,intramolecular transferase activity, phosphotransferases;GO:0003824,molecular_function,catalytic activity;GO:0004082,molecular_function,bisphosphoglycerate mutase activity;GO:0008152,biological_process,metabolic process;GO:0016853,molecular_function,isomerase activity","-"]
["TTC7A",5.364979538,1.461730723,1.872345962,4.624891073,{"v":1.75e-08,"d":"1.75E-08"},{"v":1.22e-07,"d":"1.22E-07"},"ENSG00000068724","G3R1M6,Tetratricopeptide repeat domain 7A","-","PF13181,Tetratricopeptide repeat","IPR026900,Tetratricopeptide repeat protein 7A;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","-","GO:0030097,biological_process,hemopoiesis;GO:0072659,biological_process,protein localization to plasma membrane;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0005623,cellular_component,cell","-"]
["NOL11",13.75485246,3.754259714,1.87130232,5.401037858,{"v":1E-10,"d":"1.00E-10"},{"v":1.14E-9,"d":"1.14E-09"},"ENSG00000130935","H2QDQ6,Nucleolar protein 11","XP_001164856.1,nucleolar protein 11 isoform X1","PF08168,NUC205 domain","IPR036322,WD40-repeat-containing domain superfamily;IPR012584,NUC205","ENOG410IESF,-;ENOG41118C1,-","GO:1901838,biological_process,positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0030490,biological_process,maturation of SSU-rRNA;GO:0005730,cellular_component,nucleolus;GO:0005634,cellular_component,nucleus;GO:0034455,cellular_component,t-UTP complex","-"]
["UBP1",11.92166713,3.256491206,1.87106093,6.230596079,{"v":4.17e-13,"d":"4.17E-13"},{"v":8.32e-12,"d":"8.32E-12"},"ENSG00000153560","A0A024R2L0,Upstream binding protein 1","NP_001121633.1,-;NP_055332.3,upstream-binding protein 1 isoform LBP-1b","PF04516,CP2 transcription factor","IPR037600,Upstream-binding protein 1, SAM domain;IPR007604,CP2 transcription factor;IPR013761,Sterile alpha motif/pointed domain superfamily","KOG4091,Transcription factor;ENOG410XNZ6,-","GO:0005829,cellular_component,cytosol;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001525,biological_process,angiogenesis;GO:0005654,cellular_component,nucleoplasm","-"]
["SKI",20.5043711,5.604769455,1.870146335,6.329074109,2.13E-13,4.56E-12,"ENSG00000157933","K7AV25,V-ski sarcoma viral oncogene homolog","-","PF02437,SKI/SNO/DAC family;PF08782,c-SKI Smad4 binding domain","IPR028760,Ski oncogene;IPR037000,Ski-like, DNA-binding domain superfamily;IPR009061,Putative DNA-binding domain superfamily;IPR014890,c-SKI SMAD4-binding domain;IPR003380,SKI/SNO/DAC domain;IPR010919,SAND-like domain superfamily;IPR023216,Transcription regulator SKI/SnoN","ENOG410Y8AU,-;ENOG410IFDK,-","GO:0046332,molecular_function,SMAD binding;GO:0006351,biological_process,transcription, DNA-templated","-"]
["CLDN1",59.51089636,16.28030221,1.869421687,7.127767359,{"v":3.27e-15,"d":"3.27E-15"},{"v":1.05e-13,"d":"1.05E-13"},"ENSG00000163347","H2QNY7,Claudin","XP_516949.2,-","PF00822,PMP-22/EMP/MP20/Claudin family","IPR006187,Claudin;IPR017974,Claudin, conserved site;IPR003548,Claudin-1;IPR004031,PMP-22/EMP/MP20/Claudin superfamily","ENOG410IG63,-;ENOG4111GMP,-","GO:0070830,biological_process,bicellular tight junction assembly;GO:0030054,cellular_component,cell junction;GO:0061436,biological_process,establishment of skin barrier;GO:0005923,cellular_component,bicellular tight junction;GO:0045216,biological_process,cell-cell junction organization;GO:0016338,biological_process,calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0016328,cellular_component,lateral plasma membrane;GO:0005198,molecular_function,structural molecule activity;GO:0046718,biological_process,viral entry into host cell;GO:0051260,biological_process,protein homooligomerization;GO:0016324,cellular_component,apical plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0051291,biological_process,protein heterooligomerization;GO:0016020,cellular_component,membrane;GO:0016323,cellular_component,basolateral plasma membrane;GO:0042802,molecular_function,identical protein binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0001618,molecular_function,virus receptor activity","K06087,ko04514,Cell adhesion molecules (CAMs);K06087,ko04670,Leukocyte transendothelial migration;K06087,ko04530,Tight junction;K06087,ko05160,Hepatitis C"]
["BMI1",10.92216872,2.983626981,1.86930068,4.942571426,{"v":2.57E-9,"d":"2.57E-09"},{"v":2.15e-08,"d":"2.15E-08"},"ENSG00000168283","I3LYZ3,Uncharacterized protein","XP_005325828.1,-","PF16207,RAWUL domain RING finger- and  WD40-associated ubiquitin-like;PF13923,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR032443,RAWUL domain;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XPCN,-;KOG2660,Locus-specific chromosome binding proteins","GO:2001234,biological_process,negative regulation of apoptotic signaling pathway;GO:0097027,molecular_function,ubiquitin-protein transferase activator activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0050790,biological_process,regulation of catalytic activity;GO:0031519,cellular_component,PcG protein complex;GO:0000151,cellular_component,ubiquitin ligase complex;GO:0001501,biological_process,skeletal system development;GO:0021903,biological_process,rostrocaudal neural tube patterning;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0048704,biological_process,embryonic skeletal system morphogenesis;GO:0007420,biological_process,brain development;GO:0003682,molecular_function,chromatin binding;GO:0048706,biological_process,embryonic skeletal system development;GO:0000792,cellular_component,heterochromatin;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0016574,biological_process,histone ubiquitination;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0016604,cellular_component,nuclear body;GO:0006959,biological_process,humoral immune response;GO:0033092,biological_process,positive regulation of immature T cell proliferation in thymus;GO:0048103,biological_process,somatic stem cell division;GO:0006306,biological_process,DNA methylation;GO:0030890,biological_process,positive regulation of B cell proliferation;GO:0001701,biological_process,in utero embryonic development;GO:0016573,biological_process,histone acetylation;GO:2000011,biological_process,regulation of adaxial/abaxial pattern formation","-"]
["ABL1",17.36682707,4.751015536,1.868817451,6.138032774,{"v":7.7e-13,"d":"7.70E-13"},1.44E-11,"ENSG00000097007","Q59FK4,Tyrosine-protein kinase","NP_005148.2,tyrosine-protein kinase ABL1 isoform a;NP_009297.2,tyrosine-protein kinase ABL1 isoform b","PF08919,-actin binding;PF00018,SH3 domain;PF00017,SH2 domain;PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR008266,Tyrosine-protein kinase, active site;IPR036860,SH2 domain superfamily;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR000980,SH2 domain;IPR011009,Protein kinase-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR015015,F-actin binding;IPR035837,Tyrosine-protein kinase ABL, SH2 domain;IPR001452,SH3 domain;IPR033221,Tyrosine-protein kinase ABL1/transforming protein Abl;IPR017441,Protein kinase, ATP binding site;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0197,Tyrosine kinases","GO:0016301,molecular_function,kinase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004715,molecular_function,non-membrane spanning protein tyrosine kinase activity;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation","K06619,ko05200,Pathways in cancer;K06619,ko04014,Ras signaling pathway;K06619,ko04012,ErbB signaling pathway;K06619,ko04360,Axon guidance;K06619,ko05131,Shigellosis;K06619,ko04110,Cell cycle;K06619,ko05206,MicroRNAs in cancer;K06619,ko04722,Neurotrophin signaling pathway;K06619,ko05220,Chronic myeloid leukemia;K06619,ko05130,Pathogenic Escherichia coli infection;K06619,ko05416,Viral myocarditis"]
["TMEM135",3.823910888,1.042269408,1.868459064,3.71427169,{"v":8.66e-06,"d":"8.66E-06"},{"v":3.34e-05,"d":"3.34E-05"},"ENSG00000166575","H2Q4I7,Transmembrane protein 135","XP_001175336.1,transmembrane protein 135 isoform X1","PF15982,N-terminal cysteine-rich region of Transmembrane protein 135;PF02466,Tim17/Tim22/Tim23/Pmp24 family","IPR031926,Transmembrane protein 135, N-terminal domain;IPR003397,Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24;IPR026749,Transmembrane protein 135","KOG1398,Uncharacterized conserved protein;ENOG410YP91,-","GO:0005777,cellular_component,peroxisome;GO:0009409,biological_process,response to cold;GO:0090140,biological_process,regulation of mitochondrial fission;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0032094,biological_process,response to food;GO:0005811,cellular_component,lipid droplet;GO:0016021,cellular_component,integral component of membrane","-"]
["STK40",37.46687802,10.25780016,1.868265726,7.070719467,{"v":4.43e-15,"d":"4.43E-15"},{"v":1.38e-13,"d":"1.38E-13"},"ENSG00000196182","G3R7H6,Serine/threonine kinase 40","XP_004025515.1,-;XP_018870942.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR024236,Serine/threonine-protein kinase 40;IPR008271,Serine/threonine-protein kinase, active site;IPR024104,Pseudokinase tribbles family/serine-threonine-protein kinase 40;IPR000719,Protein kinase domain","-","GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["SCARA3",38.87960702,10.64845232,1.867530271,6.656157592,{"v":3.73e-14,"d":"3.73E-14"},{"v":9.38e-13,"d":"9.38E-13"},"ENSG00000168077","H2PPX0,Scavenger receptor class A member 3","XP_002818982.1,scavenger receptor class A member 3","PF01391,Collagen triple helix repeat (20 copies)","IPR008160,Collagen triple helix repeat","ENOG410IER2,-;ENOG410Z17S,-","GO:0005783,cellular_component,endoplasmic reticulum;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["INPP5F",3.562458813,0.972902869,1.866727905,3.946388595,{"v":2.6e-06,"d":"2.60E-06"},{"v":1.13E-5,"d":"1.13E-05"},"ENSG00000198825","H2R382,Inositol polyphosphate-5-phosphatase F","XP_508074.2,phosphatidylinositide phosphatase SAC2 isoform X1","PF02383,SacI homology domain;PF12456,Inositol phosphatase","IPR002013,SAC domain;IPR034753,hSac2 domain;IPR022158,Inositol phosphatase","COG5329,Phosphoinositide polyphosphatase (Sac family);KOG1890,Phosphoinositide phosphatase SAC1","GO:0046856,biological_process,phosphatidylinositol dephosphorylation;GO:0042578,molecular_function,phosphoric ester hydrolase activity;GO:0072583,biological_process,clathrin-dependent endocytosis;GO:0034596,molecular_function,phosphatidylinositol phosphate 4-phosphatase activity;GO:0045334,cellular_component,clathrin-coated endocytic vesicle;GO:0001921,biological_process,positive regulation of receptor recycling;GO:0005769,cellular_component,early endosome;GO:0034595,molecular_function,phosphatidylinositol phosphate 5-phosphatase activity;GO:0031161,biological_process,phosphatidylinositol catabolic process;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0008344,biological_process,adult locomotory behavior;GO:0048015,biological_process,phosphatidylinositol-mediated signaling;GO:0030425,cellular_component,dendrite;GO:0030424,cellular_component,axon;GO:0005905,cellular_component,clathrin-coated pit;GO:0014898,biological_process,cardiac muscle hypertrophy in response to stress;GO:0043025,cellular_component,neuronal cell body;GO:0048681,biological_process,negative regulation of axon regeneration;GO:2000145,biological_process,regulation of cell motility;GO:0052833,molecular_function,inositol monophosphate 4-phosphatase activity;GO:0055037,cellular_component,recycling endosome;GO:2001135,biological_process,regulation of endocytic recycling;GO:0042532,biological_process,negative regulation of tyrosine phosphorylation of STAT protein","-"]
["KLHL20",5.637864286,1.540495746,1.866265307,4.016067237,{"v":1.61E-6,"d":"1.61E-06"},{"v":7.3e-06,"d":"7.30E-06"},"ENSG00000076321","I3MPF4,Kelch like family member 20","XP_005319848.1,-","PF01344,Kelch motif;PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch","IPR011705,BTB/Kelch-associated;IPR011333,SKP1/BTB/POZ domain superfamily;IPR015915,Kelch-type beta propeller;IPR017096,BTB-kelch protein;IPR006652,Kelch repeat type 1;IPR000210,BTB/POZ domain","KOG4441,Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes;ENOG410XNX8,-","GO:0005794,cellular_component,Golgi apparatus;GO:0006895,biological_process,Golgi to endosome transport;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0016567,biological_process,protein ubiquitination;GO:0016605,cellular_component,PML body;GO:0031463,cellular_component,Cul3-RING ubiquitin ligase complex;GO:0005802,cellular_component,trans-Golgi network;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0019964,molecular_function,interferon-gamma binding;GO:1990390,biological_process,protein K33-linked ubiquitination;GO:0005829,cellular_component,cytosol","-"]
["PIK3R1",6.770712789,1.856363904,1.865026866,5.568153956,{"v":3.16e-11,"d":"3.16E-11"},4.05E-10,"ENSG00000145675","H2QR04,Phosphoinositide-3-kinase regulatory subunit 1","XP_003950591.1,phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2","PF00017,SH2 domain;PF00620,RhoGAP domain;PF16454,Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain","IPR036860,SH2 domain superfamily;IPR032498,PI3K p85 subunit, inter-SH2 domain;IPR035022,PI3K p85 subunit, N-terminal SH2 domain;IPR035020,PI3K p85 subunit, C-terminal SH2 domain;IPR000980,SH2 domain;IPR001720,PI3K p85/p55 subunit","ENOG410XP6R,-;KOG4637,Adaptor for phosphoinositide 3-kinase","GO:0016301,molecular_function,kinase activity;GO:0046935,molecular_function,1-phosphatidylinositol-3-kinase regulator activity;GO:0008286,biological_process,insulin receptor signaling pathway;GO:0043551,biological_process,regulation of phosphatidylinositol 3-kinase activity;GO:2001275,biological_process,positive regulation of glucose import in response to insulin stimulus;GO:0005942,cellular_component,phosphatidylinositol 3-kinase complex;GO:0035014,molecular_function,phosphatidylinositol 3-kinase regulator activity;GO:0016310,biological_process,phosphorylation;GO:0046854,biological_process,phosphatidylinositol phosphorylation","K02649,ko04973,Carbohydrate digestion and absorption;K02649,ko04810,Regulation of actin cytoskeleton;K02649,ko01522,Endocrine resistance;K02649,ko05231,Choline metabolism in cancer;K02649,ko04211,Longevity regulating pathway;K02649,ko04015,Rap1 signaling pathway;K02649,ko04650,Natural killer cell mediated cytotoxicity;K02649,ko04917,Prolactin signaling pathway;K02649,ko05166,HTLV-I infection;K02649,ko04722,Neurotrophin signaling pathway;K02649,ko04070,Phosphatidylinositol signaling system;K02649,ko04910,Insulin signaling pathway;K02649,ko04066,HIF-1 signaling pathway;K02649,ko04024,cAMP signaling pathway;K02649,ko04611,Platelet activation;K02649,ko04930,Type II diabetes mellitus;K02649,ko04062,Chemokine signaling pathway;K02649,ko04510,Focal adhesion;K02649,ko04664,Fc epsilon RI signaling pathway;K02649,ko04370,VEGF signaling pathway;K02649,ko05223,Non-small cell lung cancer;K02649,ko05145,Toxoplasmosis;K02649,ko05220,Chronic myeloid leukemia;K02649,ko05161,Hepatitis B;K02649,ko05213,Endometrial cancer;K02649,ko04012,ErbB signaling pathway;K02649,ko04261,Adrenergic signaling in cardiomyocytes;K02649,ko05211,Renal cell carcinoma;K02649,ko05215,Prostate cancer;K02649,ko04933,AGE-RAGE signaling pathway in diabetic complications;K02649,ko04670,Leukocyte transendothelial migration;K02649,ko04630,Jak-STAT signaling pathway;K02649,ko04668,TNF signaling pathway;K02649,ko05100,Bacterial invasion of epithelial cells;K02649,ko04915,Estrogen signaling pathway;K02649,ko05169,Epstein-Barr virus infection;K02649,ko04068,FoxO signaling pathway;K02649,ko05162,Measles;K02649,ko04923,Regulation of lipolysis in adipocytes;K02649,ko04932,Non-alcoholic fatty liver disease (NAFLD);K02649,ko05164,Influenza A;K02649,ko05146,Amoebiasis;K02649,ko04210,Apoptosis;K02649,ko04151,PI3K-Akt signaling pathway;K02649,ko04360,Axon guidance;K02649,ko04150,mTOR signaling pathway;K02649,ko04960,Aldosterone-regulated sodium reabsorption;K02649,ko05218,Melanoma;K02649,ko04660,T cell receptor signaling pathway;K02649,ko04725,Cholinergic synapse;K02649,ko05200,Pathways in cancer;K02649,ko05221,Acute myeloid leukemia;K02649,ko04213,Longevity regulating pathway - multiple species;K02649,ko05214,Glioma;K02649,ko04921,Oxytocin signaling pathway;K02649,ko04914,Progesterone-mediated oocyte maturation;K02649,ko04750,Inflammatory mediator regulation of TRP channels;K02649,ko04072,Phospholipase D signaling pathway;K02649,ko05203,Viral carcinogenesis;K02649,ko04071,Sphingolipid signaling pathway;K02649,ko05210,Colorectal cancer;K02649,ko05142,Chagas disease (American trypanosomiasis);K02649,ko01524,Platinum drug resistance;K02649,ko04022,cGMP-PKG signaling pathway;K02649,ko04666,Fc gamma R-mediated phagocytosis;K02649,ko01521,EGFR tyrosine kinase inhibitor resistance;K02649,ko04931,Insulin resistance;K02649,ko05222,Small cell lung cancer;K02649,ko04152,AMPK signaling pathway;K02649,ko04550,Signaling pathways regulating pluripotency of stem cells;K02649,ko04919,Thyroid hormone signaling pathway;K02649,ko04662,B cell receptor signaling pathway;K02649,ko04620,Toll-like receptor signaling pathway;K02649,ko04014,Ras signaling pathway;K02649,ko05205,Proteoglycans in cancer;K02649,ko05230,Central carbon metabolism in cancer;K02649,ko05160,Hepatitis C;K02649,ko05212,Pancreatic cancer;K02649,ko04380,Osteoclast differentiation"]
["BMP5",7.270414367,1.989858978,1.864797755,4.265086385,{"v":2.9e-07,"d":"2.90E-07"},{"v":1.53E-6,"d":"1.53E-06"},"ENSG00000112175","G7P2W6,Uncharacterized protein","XP_005552747.1,-","PF00019,Transforming growth factor beta like domain;PF00688,TGF-beta propeptide","IPR001839,Transforming growth factor-beta, C-terminal;IPR015615,Transforming growth factor-beta-related;IPR017948,Transforming growth factor beta, conserved site;IPR029034,Cystine-knot cytokine;IPR001111,TGF-beta, propeptide","-","GO:0010469,biological_process,regulation of signaling receptor activity;GO:0003323,biological_process,type B pancreatic cell development;GO:1900006,biological_process,positive regulation of dendrite development;GO:0008083,molecular_function,growth factor activity;GO:0032348,biological_process,negative regulation of aldosterone biosynthetic process;GO:2000065,biological_process,negative regulation of cortisol biosynthetic process;GO:0043569,biological_process,negative regulation of insulin-like growth factor receptor signaling pathway;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0010894,biological_process,negative regulation of steroid biosynthetic process;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0070700,molecular_function,BMP receptor binding;GO:2000105,biological_process,positive regulation of DNA-dependent DNA replication;GO:0050679,biological_process,positive regulation of epithelial cell proliferation;GO:0010862,biological_process,positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0005576,cellular_component,extracellular region","K04663,ko04390,Hippo signaling pathway;K04663,ko04350,TGF-beta signaling pathway"]
["KDM5B",7.698013311,2.113608065,1.863369997,5.914882079,{"v":4.1e-12,"d":"4.10E-12"},6.43E-11,"ENSG00000117139","H2Q0X2,Uncharacterized protein","XP_514104.5,lysine-specific demethylase 5B isoform X1","PF00628,PHD-finger;PF02375,jmjN domain;PF08429,PLU-1-like protein;PF02373,JmjC domain, hydroxylase;PF02928,C5HC2 zinc finger;PF01388,ARID/BRIGHT DNA binding domain","IPR001606,ARID DNA-binding domain;IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR013637,Lysine-specific demethylase-like domain;IPR003349,JmjN domain;IPR036431,ARID DNA-binding domain superfamily;IPR019787,Zinc finger, PHD-finger;IPR004198,Zinc finger, C5HC2-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR019786,Zinc finger, PHD-type, conserved site;IPR003347,JmjC domain","KOG1246,DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain;ENOG410XR9J,-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding","-"]
["FAM175B",12.77776851,3.504421873,1.862957605,4.66180618,{"v":2.59E-8,"d":"2.59E-08"},{"v":1.74E-7,"d":"1.74E-07"},"ENSG00000165660","H2R3J2,Family with sequence similarity 175, member B","XP_003312863.1,BRISC complex subunit Abro1","-","IPR023240,FAM175 family, BRISC complex, Abro1 subunit;IPR037518,MPN domain;IPR023238,FAM175 family","ENOG410IPEG,-;ENOG410ZUYJ,-","GO:0008608,biological_process,attachment of spindle microtubules to kinetochore;GO:0002931,biological_process,response to ischemia;GO:0005737,cellular_component,cytoplasm;GO:0031616,cellular_component,spindle pole centrosome;GO:0008017,molecular_function,microtubule binding;GO:0005634,cellular_component,nucleus;GO:0070536,biological_process,protein K63-linked deubiquitination;GO:0030496,cellular_component,midbody;GO:0036449,cellular_component,microtubule minus-end;GO:0000278,biological_process,mitotic cell cycle;GO:0005813,cellular_component,centrosome;GO:0070552,cellular_component,BRISC complex;GO:0007059,biological_process,chromosome segregation;GO:0031593,molecular_function,polyubiquitin modification-dependent protein binding;GO:0090307,biological_process,mitotic spindle assembly","-"]
["SCAMP1",11.44050054,3.144439641,1.861035575,5.256312402,3.29E-10,{"v":3.38e-09,"d":"3.38E-09"},"ENSG00000085365","G7MUU1,Secretory carrier-associated membrane protein","XP_002804485.2,-","PF04144,SCAMP family","IPR007273,SCAMP","-","GO:0015031,biological_process,protein transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["KDM3B",25.11511648,6.914641223,1.860176192,7.005984351,{"v":8.56e-15,"d":"8.56E-15"},{"v":2.5e-13,"d":"2.50E-13"},"ENSG00000120733","G3SB43,Lysine demethylase 3B","-","PF02373,JmjC domain, hydroxylase","IPR003347,JmjC domain","-","GO:0005654,cellular_component,nucleoplasm","-"]
["SUZ12",21.4356111,5.905649384,1.858911967,6.500308478,1.24E-13,{"v":2.77e-12,"d":"2.77E-12"},"ENSG00000178691","A0A0D9R2N5,SUZ12 polycomb repressive complex 2 subunit","XP_008009158.1,-","PF09733,VEFS-Box of polycomb protein","IPR019135,Polycomb protein, VEFS-Box","-","GO:0003723,molecular_function,RNA binding;GO:0070734,biological_process,histone H3-K27 methylation;GO:0032993,cellular_component,protein-DNA complex;GO:0042054,molecular_function,histone methyltransferase activity;GO:0016574,biological_process,histone ubiquitination;GO:0045596,biological_process,negative regulation of cell differentiation;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0031490,molecular_function,chromatin DNA binding;GO:0046976,molecular_function,histone methyltransferase activity (H3-K27 specific);GO:0001739,cellular_component,sex chromatin;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0035064,molecular_function,methylated histone binding;GO:0035098,cellular_component,ESC/E(Z) complex;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0005730,cellular_component,nucleolus;GO:0016571,biological_process,histone methylation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["LIPH",27.36379646,7.551680563,1.856244545,6.189426567,{"v":8.02e-13,"d":"8.02E-13"},{"v":1.5E-11,"d":"1.50E-11"},"ENSG00000163898","H2R0M0,Uncharacterized protein","XP_516924.4,lipase member H isoform X1","PF00151,Lipase","IPR016272,Lipase, LIPH-type;IPR033906,Lipase, N-terminal;IPR000734,Triacylglycerol lipase family;IPR029058,Alpha/Beta hydrolase fold;IPR013818,Lipase/vitellogenin","ENOG410IKYJ,-;ENOG4111AHY,-","GO:0006629,biological_process,lipid metabolic process;GO:0005886,cellular_component,plasma membrane;GO:0008201,molecular_function,heparin binding;GO:0052689,molecular_function,carboxylic ester hydrolase activity;GO:0004620,molecular_function,phospholipase activity;GO:0016042,biological_process,lipid catabolic process;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space","-"]
["ZDHHC7",18.34946651,5.063965075,1.855601918,5.560853442,{"v":4.24e-11,"d":"4.24E-11"},{"v":5.25e-10,"d":"5.25E-10"},"ENSG00000153786","H2QBM8,Palmitoyltransferase","XP_016785789.1,-;XP_009429616.1,-","PF01529,HHC palmitoyltransferase","IPR001594,Palmitoyltransferase, DHHC domain","KOG1311,DHHC-type Zn-finger proteins;COG5273,Uncharacterized protein containing DHHC-type Zn finger","GO:0019706,molecular_function,protein-cysteine S-palmitoyltransferase activity;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016740,molecular_function,transferase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GNPTAB",5.924161629,1.63491116,1.855115952,5.222753514,{"v":4.94e-10,"d":"4.94E-10"},{"v":4.9E-9,"d":"4.90E-09"},"ENSG00000111670","H2Q6Q4,N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits","XP_001155334.3,N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1","PF06464,MAP1-binding Domain;PF00066,LNR domain;PF17103,Stealth protein CR4, conserved region 4;PF11380,Stealth protein CR2, conserved region 2;PF17101,Stealth protein CR1, conserved region 1;PF17102,Stealth protein CR3, conserved region 3","IPR018247,EF-Hand 1, calcium-binding site;IPR021520,Stealth protein CR2, conserved region 2;IPR031357,Stealth protein CR3, conserved region 3;IPR000800,Notch domain;IPR010506,DMAP1-binding domain;IPR031356,Stealth protein CR4, conserved region 4;IPR002048,EF-hand domain;IPR035993,Notch-like domain superfamily;IPR031358,Stealth protein CR1, conserved region 1","ENOG410XYNB,-;ENOG410IEF9,-","GO:0005794,cellular_component,Golgi apparatus;GO:0033299,biological_process,secretion of lysosomal enzymes;GO:0003976,molecular_function,UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity;GO:0009306,biological_process,protein secretion;GO:0016740,molecular_function,transferase activity;GO:0005509,molecular_function,calcium ion binding;GO:0016021,cellular_component,integral component of membrane;GO:0000139,cellular_component,Golgi membrane;GO:0016772,molecular_function,transferase activity, transferring phosphorus-containing groups;GO:0016020,cellular_component,membrane;GO:0046835,biological_process,carbohydrate phosphorylation;GO:0016256,biological_process,N-glycan processing to lysosome;GO:0007040,biological_process,lysosome organization","K08239,ko04142,Lysosome"]
["TAF5L",8.147416089,2.248470303,1.854908739,5.100423854,{"v":1.04e-09,"d":"1.04E-09"},{"v":9.51e-09,"d":"9.51E-09"},"ENSG00000135801","H2Q1B2,TAF5-like RNA polymerase II, p300/CBP-associated factor","XP_016796135.1,-;XP_016796136.1,-","PF00400,WD domain, G-beta repeat;PF04494,WD40 associated region in TFIID subunit, NTD2 domain","IPR019775,WD40 repeat, conserved site;IPR007582,TFIID subunit TAF5, NTD2 domain;IPR017986,WD40-repeat-containing domain;IPR037826,TAF5L;IPR036322,WD40-repeat-containing domain superfamily;IPR037264,TFIID subunit TAF5, NTD2 domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat","KOG0263,Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA);ENOG410XPM5,-","GO:0033276,cellular_component,transcription factor TFTC complex;GO:0030914,cellular_component,STAGA complex","K03130,ko05168,Herpes simplex infection;K03130,ko03022,Basal transcription factors"]
["PPRC1",7.791965391,2.150375357,1.854660154,4.966707997,{"v":2.82e-09,"d":"2.82E-09"},{"v":2.34e-08,"d":"2.34E-08"},"ENSG00000148840","K7CB08,Peroxisome proliferator-activated receptor gamma, coactivator-related 1","XP_016774683.1,peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034597,PGC-1-related coactivator;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR034605,PGC-1;IPR035979,RNA-binding domain superfamily;IPR034834,PGC-1-related coactivator, RNA recognition motif","ENOG4111HH9,-;ENOG410IK9Y,-","GO:0003712,molecular_function,transcription cofactor activity;GO:0003676,molecular_function,nucleic acid binding;GO:0003723,molecular_function,RNA binding;GO:0008134,molecular_function,transcription factor binding;GO:1903506,biological_process,regulation of nucleic acid-templated transcription;GO:0005654,cellular_component,nucleoplasm","-"]
["UNK",7.666874646,2.115853636,1.854356429,4.819258471,{"v":7e-09,"d":"7.00E-09"},{"v":5.34e-08,"d":"5.34E-08"},"ENSG00000132478","G3R1E1,Unkempt family zinc finger","XP_018882272.1,-","PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type","-","GO:0048667,biological_process,cell morphogenesis involved in neuron differentiation;GO:0046872,molecular_function,metal ion binding;GO:0005844,cellular_component,polysome;GO:1990715,molecular_function,mRNA CDS binding;GO:2000766,biological_process,negative regulation of cytoplasmic translation;GO:0001764,biological_process,neuron migration","-"]
["MYO1D",4.350149217,1.200525568,1.853749319,4.565098903,{"v":3.86e-08,"d":"3.86E-08"},{"v":2.5e-07,"d":"2.50E-07"},"ENSG00000176658","H2NTA9,Uncharacterized protein","XP_009249767.1,unconventional myosin-Id isoform X2","PF06017,Unconventional myosin tail, actin- and lipid-binding;PF00063,Myosin head (motor domain);PF00612,IQ calmodulin-binding motif","IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036072,Class I myosin, motor domain;IPR010926,Class I myosin tail homology domain;IPR000048,IQ motif, EF-hand binding site;IPR036961,Kinesin motor domain superfamily","COG5022,Myosin heavy chain;KOG0164,Myosin class I heavy chain","GO:0043209,cellular_component,myelin sheath;GO:0003777,molecular_function,microtubule motor activity;GO:0005903,cellular_component,brush border;GO:0030424,cellular_component,axon;GO:0043025,cellular_component,neuronal cell body;GO:0016459,cellular_component,myosin complex;GO:0010923,biological_process,negative regulation of phosphatase activity;GO:0051641,biological_process,cellular localization;GO:0019904,molecular_function,protein domain specific binding;GO:0003779,molecular_function,actin binding;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0003774,molecular_function,motor activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0043005,cellular_component,neuron projection","-"]
["FAM198B",3.766817025,1.039541387,1.853021382,4.312344514,{"v":2.44e-07,"d":"2.44E-07"},{"v":1.31E-6,"d":"1.31E-06"},"ENSG00000164125","H2QQC7,Uncharacterized protein","-","PF15051,AM198 protein","-","-","-","-"]
["AGL",3.378612454,0.932407242,1.852839498,4.255963253,{"v":3.7E-7,"d":"3.70E-07"},{"v":1.9E-6,"d":"1.90E-06"},"ENSG00000162688","A0A0S2A4E4,Amylo-1, 6-glucosidase, 4-alpha-glucanotransferase","XP_005270614.1,-;NP_000635.2,-;NP_000019.2,glycogen debranching enzyme isoform 1;NP_000633.2,-;NP_000634.2,-","PF14701,lycogen debranching enzyme, glucanotransferase domain;PF06202,Amylo-alpha-1,6-glucosidase;PF14699,N-terminal domain from the human glycogen debranching enzyme;PF14702,Central domain of human glycogen debranching enzyme","IPR008928,Six-hairpin glycosidase superfamily;IPR006421,Glycogen debranching enzyme, metazoa;IPR032790,Glycogen debranching enzyme, C-terminal;IPR017853,Glycoside hydrolase superfamily;IPR032792,Glycogen debranching enzyme, glucanotransferase domain;IPR032788,Glycogen debranching enzyme, central domain;IPR010401,Glycogen debranching enzyme;IPR029436,Eukaryotic glycogen debranching enzyme, N-terminal domain","-","GO:0005977,biological_process,glycogen metabolic process;GO:0005980,biological_process,glycogen catabolic process;GO:0009725,biological_process,response to hormone;GO:0004135,molecular_function,amylo-alpha-1,6-glucosidase activity;GO:0030247,molecular_function,polysaccharide binding;GO:0004133,molecular_function,glycogen debranching enzyme activity;GO:0005737,cellular_component,cytoplasm;GO:0004134,molecular_function,4-alpha-glucanotransferase activity;GO:0005978,biological_process,glycogen biosynthetic process;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0051384,biological_process,response to glucocorticoid;GO:0007584,biological_process,response to nutrient;GO:0030246,molecular_function,carbohydrate binding;GO:0005634,cellular_component,nucleus;GO:0016529,cellular_component,sarcoplasmic reticulum;GO:0031593,molecular_function,polyubiquitin modification-dependent protein binding;GO:0016234,cellular_component,inclusion body","K01196,ko00500,Starch and sucrose metabolism"]
["CNTNAP3",2.743474003,0.75712591,1.852426278,4.136063028,{"v":6.41e-07,"d":"6.41E-07"},{"v":3.16e-06,"d":"3.16E-06"},"ENSG00000106714","H2QXB1,Uncharacterized protein","-","PF00754,5/8 type C domain;PF02210,Laminin G domain","IPR000421,Coagulation factor 5/8 C-terminal domain;IPR001791,Laminin G domain;IPR036056,Fibrinogen-like, C-terminal;IPR028873,Contactin-associated protein-like 3;IPR002181,Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000742,EGF-like domain;IPR008979,Galactose-binding-like domain superfamily","KOG3516,Neurexin IV;ENOG410XPHG,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["REPS2",2.309310935,0.637308442,1.852426278,4.136063028,{"v":6.41e-07,"d":"6.41E-07"},{"v":3.16e-06,"d":"3.16E-06"},"ENSG00000169891","G1REP0,RALBP1 associated Eps domain containing 2","XP_003261146.2,ralBP1-associated Eps domain-containing protein 2 isoform X1","PF12763,Cytoskeletal-regulatory complex EF hand","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR000261,EH domain;IPR011992,EF-hand domain pair","KOG1955,Ral-GTPase effector RALBP1;ENOG410XTBP,-","GO:0005509,molecular_function,calcium ion binding","-"]
["ZBTB11",3.362097526,0.927849561,1.852190246,4.072119054,{"v":1.01e-06,"d":"1.01E-06"},{"v":4.75e-06,"d":"4.75E-06"},"ENSG00000066422","H2QN13,Zinc finger and BTB domain containing 11","XP_516629.2,zinc finger and BTB domain-containing protein 11","PF00096,Zinc finger, C2H2 type;PF13912,C2H2-type zinc finger;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["BBS1",3.864282267,1.066439203,1.85193069,4.005179149,{"v":1.61E-6,"d":"1.61E-06"},{"v":7.3e-06,"d":"7.30E-06"},"ENSG00000174483","K7BAJ5,Bardet-Biedl syndrome 1","XP_001171950.2,-","PF14779,Ciliary BBSome complex subunit 1","IPR032728,Bardet-Biedl syndrome 1, N-terminal;IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR028784,Bardet-Biedl syndrome 1 protein","ENOG410IG3X,-;ENOG410Y9JX,-","GO:0042445,biological_process,hormone metabolic process;GO:0007608,biological_process,sensory perception of smell;GO:0005102,molecular_function,signaling receptor binding;GO:0060296,biological_process,regulation of cilium beat frequency involved in ciliary motility;GO:0044255,biological_process,cellular lipid metabolic process;GO:0016358,biological_process,dendrite development;GO:0021987,biological_process,cerebral cortex development;GO:0001895,biological_process,retina homeostasis;GO:0021591,biological_process,ventricular system development;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0008594,biological_process,photoreceptor cell morphogenesis;GO:1905515,biological_process,non-motile cilium assembly;GO:0005813,cellular_component,centrosome;GO:0042048,biological_process,olfactory behavior;GO:0001764,biological_process,neuron migration;GO:0061351,biological_process,neural precursor cell proliferation;GO:0045444,biological_process,fat cell differentiation;GO:0034464,cellular_component,BBSome;GO:0008104,biological_process,protein localization;GO:0048854,biological_process,brain morphogenesis;GO:0060271,biological_process,cilium assembly;GO:0030534,biological_process,adult behavior;GO:0051216,biological_process,cartilage development;GO:0031514,cellular_component,motile cilium;GO:0021766,biological_process,hippocampus development;GO:0051219,molecular_function,phosphoprotein binding;GO:0021756,biological_process,striatum development;GO:0009566,biological_process,fertilization","-"]
["NUDT4",45.66360008,12.64745784,1.851915535,8.203980109,{"v":1.31e-16,"d":"1.31E-16"},{"v":5.59e-15,"d":"5.59E-15"},"ENSG00000173598","G1R122,Uncharacterized protein","XP_012355533.1,-","PF00293,NUDIX domain","IPR015797,NUDIX hydrolase-like domain superfamily;IPR000086,NUDIX hydrolase domain;IPR020084,NUDIX hydrolase, conserved site","ENOG410ISY6,-;ENOG4111I7R,-","GO:0030515,molecular_function,snoRNA binding;GO:0016787,molecular_function,hydrolase activity","-"]
["HAS3",4.040728507,1.115133676,1.851325379,3.861079232,{"v":5.61e-06,"d":"5.61E-06"},{"v":2.25e-05,"d":"2.25E-05"},"ENSG00000103044","G3QNI4,Hyaluronan synthase 3","XP_018867521.1,-","PF13641,lycosyltransferase like family 2","IPR026108,Hyaluronan synthase 3;IPR029044,Nucleotide-diphospho-sugar transferases","-","GO:0045226,biological_process,extracellular polysaccharide biosynthetic process;GO:0085029,biological_process,extracellular matrix assembly;GO:1900106,biological_process,positive regulation of hyaluranon cable assembly;GO:0005737,cellular_component,cytoplasm;GO:0036117,cellular_component,hyaluranon cable;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0016020,cellular_component,membrane;GO:0050501,molecular_function,hyaluronan synthase activity;GO:0030213,biological_process,hyaluronan biosynthetic process;GO:0016021,cellular_component,integral component of membrane","-"]
["RAPGEF5",1.738361239,0.479741501,1.850116101,3.613300046,{"v":2.01e-05,"d":"2.01E-05"},{"v":7.14e-05,"d":"7.14E-05"},"ENSG00000136237","A8MQ07,Rap guanine nucleotide exchange factor 5","XP_005249973.1,-;NP_036426.3,rap guanine nucleotide exchange factor 5","PF00618,RasGEF N-terminal motif;PF00617,RasGEF domain","IPR000651,Ras-like guanine nucleotide exchange factor, N-terminal;IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR019804,Ras guanine-nucleotide exchange factor, conserved site;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily;IPR029071,Ubiquitin-like domain superfamily;IPR036390,Winged helix DNA-binding domain superfamily","KOG2378,cAMP-regulated guanine nucleotide exchange factor;ENOG410XPX9,-","GO:0016604,cellular_component,nuclear body;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005654,cellular_component,nucleoplasm","K08019,ko04014,Ras signaling pathway;K08019,ko04015,Rap1 signaling pathway"]
["MICB",5.940747023,1.639488288,1.849598387,3.520101214,{"v":3.54E-5,"d":"3.54E-05"},0.000118939,"ENSG00000204516","X6R344,MHC class I polypeptide-related sequence B","NP_005922.2,MHC class I polypeptide-related sequence B isoform 1 precursor","PF07654,Immunoglobulin C1-set domain;PF00129,Class I Histocompatibility antigen, domains alpha 1 and 2","IPR037055,MHC class I-like antigen recognition-like superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR011161,MHC class I-like antigen recognition-like;IPR003597,Immunoglobulin C1-set;IPR007110,Immunoglobulin-like domain;IPR011162,MHC classes I/II-like antigen recognition protein","ENOG410J8TZ,-;ENOG41118IQ,-","GO:0016021,cellular_component,integral component of membrane","K07985,ko04650,Natural killer cell mediated cytotoxicity"]
["SFSWAP",13.84034715,3.838923891,1.849186484,6.504775695,1.48E-13,{"v":3.25e-12,"d":"3.25E-12"},"ENSG00000061936","G1RAN6,Splicing factor SWAP homolog","-","PF09750,Alternative splicing regulator;PF01805,Surp module","IPR019147,Suppressor of white apricot N-terminal domain;IPR000061,SWAP/Surp;IPR035967,SWAP/Surp superfamily","KOG1847,mRNA splicing factor;ENOG410ZQGI,-","GO:0003723,molecular_function,RNA binding;GO:0000380,biological_process,alternative mRNA splicing, via spliceosome;GO:0000395,biological_process,mRNA 5'-splice site recognition;GO:0006396,biological_process,RNA processing","-"]
["USP21",4.100666696,1.131675023,1.849001432,3.420362965,{"v":4.57E-5,"d":"4.57E-05"},0.000150058,"ENSG00000143258","G7ME91,Ubiquitin carboxyl-terminal hydrolase 21","XP_014969242.1,-","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","KOG1868,Ubiquitin C-terminal hydrolase;ENOG410XP8T,-","GO:0016787,molecular_function,hydrolase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0016579,biological_process,protein deubiquitination;GO:0005886,cellular_component,plasma membrane;GO:0019784,molecular_function,NEDD8-specific protease activity","-"]
["ATP6V1A",10.36863013,2.874240746,1.848541868,5.127046037,{"v":9.54e-10,"d":"9.54E-10"},{"v":8.81e-09,"d":"8.81E-09"},"ENSG00000114573","G1QXI7,ATPase H+ transporting V1 subunit A","XP_003261872.1,-","PF02874,ATP synthase alpha/beta family, beta-barrel domain;PF00006,ATP synthase alpha/beta family, nucleotide-binding domain;PF16886,ATPsynthase alpha/beta subunit N-term extension","IPR005725,ATPase, V1 complex, subunit A;IPR031686,ATPsynthase alpha/beta subunit, N-terminal extension;IPR000194,ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004100,ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain;IPR024034,ATPase, F1/V1 complex, beta/alpha subunit, C-terminal;IPR036121,ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily;IPR022878,V-type ATP synthase catalytic alpha chain;IPR020003,ATPase, alpha/beta subunit, nucleotide-binding domain, active site;IPR023366,ATP synthase subunit alpha, N-terminal domain-like superfamily","KOG1352,Vacuolar H+-ATPase V1 sector, subunit A;COG1155,Archaeal/vacuolar-type H+-ATPase subunit A","GO:0046034,biological_process,ATP metabolic process;GO:0015991,biological_process,ATP hydrolysis coupled proton transport;GO:0033180,cellular_component,proton-transporting V-type ATPase, V1 domain;GO:0043209,cellular_component,myelin sheath;GO:0036295,biological_process,cellular response to increased oxygen levels;GO:0005902,cellular_component,microvillus;GO:0016324,cellular_component,apical plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0005739,cellular_component,mitochondrion;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0005829,cellular_component,cytosol;GO:0046961,molecular_function,proton-transporting ATPase activity, rotational mechanism;GO:0005524,molecular_function,ATP binding","K02145,ko00190,Oxidative phosphorylation;K02145,ko05323,Rheumatoid arthritis;K02145,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K02145,ko04966,Collecting duct acid secretion;K02145,ko04721,Synaptic vesicle cycle;K02145,ko04150,mTOR signaling pathway;K02145,ko05110,Vibrio cholerae infection;K02145,ko04145,Phagosome"]
["PCDHA8",2.598980065,0.717249424,1.848305537,3.31309005,{"v":8.42E-5,"d":"8.42E-05"},0.000258549,"ENSG00000204962","Q3V7A9,Protocadherin alpha","-","PF08266,Cadherin-like;PF00028,Cadherin domain;PF15974,Cadherin C-terminal cytoplasmic tail, catenin-binding region","IPR031904,Cadherin, C-terminal catenin-binding domain;IPR002126,Cadherin;IPR013164,Cadherin, N-terminal;IPR015919,Cadherin-like;IPR020894,Cadherin conserved site","-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["TJP1",13.51193548,3.752204564,1.847575817,6.61865048,{"v":8.56e-14,"d":"8.56E-14"},1.98E-12,"ENSG00000104067","G3V1L9,Tight junction protein 1","NP_001317168.1,tight junction protein ZO-1 isoform e","PF07653,Variant SH3 domain;PF00791,ZU5 domain;PF00625,uanylate kinase;PF00595,PDZ domain (Also known as DHR or GLGF)","IPR005418,Tight junction protein ZO-1;IPR000906,ZU5 domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001478,PDZ domain;IPR005417,Tight junction protein ZO;IPR035597,ZO-1, SH3 domain;IPR036028,SH3-like domain superfamily;IPR008144,Guanylate kinase-like domain;IPR008145,Guanylate kinase/L-type calcium channel beta subunit;IPR001452,SH3 domain;IPR036034,PDZ superfamily","KOG3580,Tight junction proteins;ENOG410XQP3,-","GO:0007605,biological_process,sensory perception of sound;GO:0005912,cellular_component,adherens junction;GO:0071253,molecular_function,connexin binding;GO:0043116,biological_process,negative regulation of vascular permeability;GO:0014704,cellular_component,intercalated disc;GO:0005886,cellular_component,plasma membrane;GO:0045471,biological_process,response to ethanol;GO:0005634,cellular_component,nucleus;GO:0005923,cellular_component,bicellular tight junction;GO:0005737,cellular_component,cytoplasm;GO:0005913,cellular_component,cell-cell adherens junction;GO:0032991,cellular_component,protein-containing complex;GO:0005829,cellular_component,cytosol;GO:0032496,biological_process,response to lipopolysaccharide;GO:0016327,cellular_component,apicolateral plasma membrane;GO:0045177,cellular_component,apical part of cell;GO:0030054,cellular_component,cell junction;GO:0046581,cellular_component,intercellular canaliculus;GO:0016324,cellular_component,apical plasma membrane;GO:0008022,molecular_function,protein C-terminus binding;GO:0016020,cellular_component,membrane;GO:0071000,biological_process,response to magnetism;GO:0070160,cellular_component,occluding junction;GO:0071333,biological_process,cellular response to glucose stimulus;GO:0005911,cellular_component,cell-cell junction;GO:0019904,molecular_function,protein domain specific binding;GO:0042493,biological_process,response to drug;GO:0001825,biological_process,blastocyst formation","-"]
["CDK14",1.909122642,0.526867109,1.84748388,3.197040358,0.000158433,0.000459399,"ENSG00000058091","A0A0D9RJ97,Cyclin dependent kinase 14","XP_007980416.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0030332,molecular_function,cyclin binding;GO:0004693,molecular_function,cyclin-dependent protein serine/threonine kinase activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005737,cellular_component,cytoplasm;GO:0000308,cellular_component,cytoplasmic cyclin-dependent protein kinase holoenzyme complex;GO:0005524,molecular_function,ATP binding;GO:0060828,biological_process,regulation of canonical Wnt signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0000086,biological_process,G2/M transition of mitotic cell cycle;GO:0051726,biological_process,regulation of cell cycle;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0004672,molecular_function,protein kinase activity","-"]
["TTYH3",7.709996559,2.13844637,1.847433835,4.961148558,{"v":2.82e-09,"d":"2.82E-09"},{"v":2.34e-08,"d":"2.34E-08"},"ENSG00000136295","A0A024R816,Protein tweety homolog","NP_079526.1,protein tweety homolog 3","PF04906,Tweety","IPR006990,Tweety","KOG4433,Tweety transmembrane/cell surface protein;ENOG410ZNTN,-","GO:1902476,biological_process,chloride transmembrane transport;GO:0006821,biological_process,chloride transport;GO:0034707,cellular_component,chloride channel complex;GO:0005254,molecular_function,chloride channel activity;GO:0006811,biological_process,ion transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["BTBD8",1.725978669,0.476324241,1.846498984,3.0706358,0.000425204,1.115918E-3,"ENSG00000189195","A0A1B0GUL6,Uncharacterized protein","-","PF15363,omain of unknown function (DUF4596);PF00651,BTB/POZ domain","IPR027907,Domain of unknown function DUF4596;IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily","-","GO:0005654,cellular_component,nucleoplasm","-"]
["PTER",2.966027296,0.818544704,1.846498984,3.0706358,0.000425204,1.115918E-3,"ENSG00000165983","G3RFD4,Phosphotriesterase related","XP_018891098.1,phosphotriesterase-related protein","PF02126,Phosphotriesterase family","IPR001559,Phosphotriesterase;IPR032466,Metal-dependent hydrolase;IPR017947,Aryldialkylphosphatase, zinc-binding site","-","GO:0008270,molecular_function,zinc ion binding;GO:0009056,biological_process,catabolic process;GO:0016788,molecular_function,hydrolase activity, acting on ester bonds;GO:0046872,molecular_function,metal ion binding;GO:0030855,biological_process,epithelial cell differentiation","-"]
["CCZ1",6.240205964,1.732321122,1.845673594,4.732913424,{"v":1.63E-8,"d":"1.63E-08"},{"v":1.15E-7,"d":"1.15E-07"},"ENSG00000122674","H2QU52,Uncharacterized protein","XP_519566.2,vacuolar fusion protein CCZ1 homolog isoform X1","PF08217,ungal domain of unknown function (DUF1712)","IPR013176,Protein of unknown function DUF1712, fungi","KOG2622,Putative myrosinase precursor;ENOG410XRE1,-","GO:0016192,biological_process,vesicle-mediated transport;GO:0031982,cellular_component,vesicle","-"]
["RP3-510L9.1",15.17856042,4.188879269,1.845296837,2.931828978,0.000430003,1.126307E-3,"-","-","-","-","-","-","-","-"]
["NRIP1",27.69483394,7.712450161,1.843809166,7.242848277,{"v":5.08e-15,"d":"5.08E-15"},{"v":1.56e-13,"d":"1.56E-13"},"ENSG00000180530","A8K171,cDNA FLJ77253, highly similar to Homo sapiens nuclear receptor interacting protein 1","NP_003480.2,nuclear receptor-interacting protein 1","PF15688,Nuclear receptor-interacting protein 1 repression 2;PF15689,Nuclear receptor-interacting protein 1 repression 3;PF15687,Nuclear receptor-interacting protein 1 repression 1;PF15690,Nuclear receptor-interacting protein 1 repression 4","IPR031406,Nuclear receptor-interacting protein 1, repression domain 2;IPR031407,Nuclear receptor-interacting protein 1, repression domain 3;IPR031408,Nuclear receptor-interacting protein 1, repression domain 4;IPR026649,Nuclear receptor-interacting protein 1;IPR031405,Nuclear receptor-interacting protein 1, repression domain 1","ENOG410XPVS,-;ENOG410IFW7,-","GO:0003712,molecular_function,transcription cofactor activity;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0005102,molecular_function,signaling receptor binding;GO:0005634,cellular_component,nucleus","-"]
["AGAP2",1.411772564,0.389611706,1.843796643,2.777896439,0.000878105,0.002140789,"ENSG00000135439","F8VVT9,Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2","NP_001116244.1,arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform PIKE-L;XP_016874261.1,-","PF12796,Ankyrin repeats (3 copies);PF01412,Putative GTPase activating protein for Arf;PF00071,Ras family","IPR037278,ARFGAP/RecO-like zinc finger;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR038508,ArfGAP domain superfamily;IPR001806,Small GTPase superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR001164,Arf GTPase activating protein;IPR002110,Ankyrin repeat","COG5347,GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport;KOG0705,GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains)","GO:0046427,biological_process,positive regulation of JAK-STAT cascade;GO:0033601,biological_process,positive regulation of mammary gland epithelial cell proliferation;GO:0019901,molecular_function,protein kinase binding;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0005730,cellular_component,nucleolus;GO:0005525,molecular_function,GTP binding;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0032147,biological_process,activation of protein kinase activity;GO:0046872,molecular_function,metal ion binding;GO:0030295,molecular_function,protein kinase activator activity;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0005739,cellular_component,mitochondrion;GO:0005096,molecular_function,GTPase activator activity;GO:0003924,molecular_function,GTPase activity;GO:0060749,biological_process,mammary gland alveolus development;GO:0005634,cellular_component,nucleus;GO:2001240,biological_process,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand","K17848,ko04144,Endocytosis;K17848,ko04068,FoxO signaling pathway"]
["SLC17A5",2.635517706,0.727332841,1.843796643,2.777896439,0.000878105,0.002140789,"ENSG00000119899","H0UI05,Solute carrier family 17","-","-","IPR036259,MFS transporter superfamily;IPR020846,Major facilitator superfamily domain;IPR011701,Major facilitator superfamily","KOG2532,Permease of the major facilitator superfamily;ENOG410XPWC,-","GO:0055085,biological_process,transmembrane transport;GO:0016021,cellular_component,integral component of membrane;GO:0008643,biological_process,carbohydrate transport;GO:0016020,cellular_component,membrane","-"]
["SPAG5",15.05823655,4.191601088,1.843418624,5.746052261,{"v":1.76e-11,"d":"1.76E-11"},{"v":2.41e-10,"d":"2.41E-10"},"ENSG00000076382","A8K8N3,cDNA FLJ78740, highly similar to Homo sapiens sperm associated antigen 5","-","-","IPR028728,Sperm-associated antigen 5","ENOG410IIA9,-;ENOG410YG9P,-","GO:0051988,biological_process,regulation of attachment of spindle microtubules to kinetochore;GO:0051301,biological_process,cell division","-"]
["RP11-138I18.1",9.004447546,2.484988208,1.841871876,2.605103984,0.002660733,0.005829703,"ENSG00000271360","G1SF21,Uncharacterized protein","-","-","-","ENOG410JJ6G,-;ENOG41117N4,-","-","-"]
["SHANK2",0.446737534,0.123287686,1.841871876,2.605103984,0.002660733,0.005829703,"ENSG00000162105","G7NBN5,Uncharacterized protein","-","PF12796,Ankyrin repeats (3 copies);PF16511,N-terminal or F0 domain of Talin-head FERM;PF00595,PDZ domain (Also known as DHR or GLGF);PF07653,Variant SH3 domain;PF00536,SAM domain (Sterile alpha motif)","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001478,PDZ domain;IPR002110,Ankyrin repeat;IPR032425,Talin, N-terminal F0 domain;IPR036028,SH3-like domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR001452,SH3 domain;IPR001660,Sterile alpha motif domain;IPR036034,PDZ superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","-","-"]
["RP11-15L13.4",16.58903211,4.578131967,1.841871876,2.605103984,0.002660733,0.005829703,"ENSG00000272910","A0A226MHP7,Uncharacterized protein","-","-","IPR004000,Actin family;IPR029912,Actin-like protein 6A","-","GO:0043044,biological_process,ATP-dependent chromatin remodeling;GO:0071564,cellular_component,npBAF complex","-"]
["TIMM17B",3.243991056,0.895255314,1.841871876,2.605103984,0.002660733,0.005829703,"ENSG00000126768","G1R8V5,Translocase of inner mitochondrial membrane 17B","XP_003276888.1,mitochondrial import inner membrane translocase subunit Tim17-B isoform X1","PF02466,Tim17/Tim22/Tim23/Pmp24 family","IPR003397,Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24","COG5596,Mitochondrial import inner membrane translocase, subunit TIM22;KOG1652,Mitochondrial import inner membrane translocase, subunit TIM17","GO:0031305,cellular_component,integral component of mitochondrial inner membrane;GO:0005744,cellular_component,mitochondrial inner membrane presequence translocase complex;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CLIP4",6.505339028,1.81215796,1.841376819,5.057770393,{"v":1.94e-09,"d":"1.94E-09"},{"v":1.67e-08,"d":"1.67E-08"},"ENSG00000115295","A8K6D0,cDNA FLJ75496, highly similar to Homo sapiens restin-like 2","NP_001274457.1,CAP-Gly domain-containing linker protein 4 isoform 2","PF12796,Ankyrin repeats (3 copies);PF01302,CAP-Gly domain","IPR000938,CAP Gly-rich domain;IPR002110,Ankyrin repeat;IPR028397,CAP-Gly domain-containing linker protein 4;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR036859,CAP Gly-rich domain superfamily","KOG4568,Cytoskeleton-associated protein and related proteins;COG5244,Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B;KOG0241,Kinesin-like protein","-","-"]
["C2CD2",3.146995648,0.876105468,1.84005774,4.187695632,{"v":7.28e-07,"d":"7.28E-07"},{"v":3.54E-6,"d":"3.54E-06"},"ENSG00000157617","H2QL21,C2 calcium-dependent domain containing 2","XP_001135072.1,C2 domain-containing protein 2","PF00168,C2 domain","IPR000008,C2 domain;IPR035892,C2 domain superfamily","ENOG4112CMM,-;ENOG410IGE7,-","-","-"]
["CCDC107",4.882662343,1.347485038,1.839312586,2.408135653,0.005823769,0.011760812,"ENSG00000159884","H2QX84,Coiled-coil domain containing 107","XP_009454856.1,coiled-coil domain-containing protein 107 isoform X1","-","-","ENOG41118NC,-;ENOG410IW9E,-","-","-"]
["MAPKAP1",33.9228779,9.478470819,1.838972498,7.20281575,{"v":6.92e-15,"d":"6.92E-15"},2.07E-13,"ENSG00000119487","G3QT17,Mitogen-activated protein kinase associated protein 1","XP_004048654.1,-;XP_018889424.1,-","PF05422,Stress-activated map kinase interacting protein 1 (SIN1);PF16979,SAPK-interacting protein 1 (Sin1), Pleckstrin-homology;PF16978,SAPK-interacting protein 1 (Sin1), middle CRIM domain","IPR031313,SAPK-interacting protein 1, Pleckstrin-homology domain;IPR008828,TORC2 component Sin1/Avo1;IPR031567,Sin1, middle CRIM domain;IPR032679,Sin1, N-terminal;IPR011993,PH-like domain superfamily","-","GO:0005546,molecular_function,phosphatidylinositol-4,5-bisphosphate binding;GO:0005794,cellular_component,Golgi apparatus;GO:0019901,molecular_function,protein kinase binding;GO:0017016,molecular_function,Ras GTPase binding;GO:0005547,molecular_function,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0046580,biological_process,negative regulation of Ras protein signal transduction;GO:0031932,cellular_component,TORC2 complex;GO:0080025,molecular_function,phosphatidylinositol-3,5-bisphosphate binding;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0043325,molecular_function,phosphatidylinositol-3,4-bisphosphate binding;GO:0070300,molecular_function,phosphatidic acid binding;GO:0005654,cellular_component,nucleoplasm","K20410,ko04150,mTOR signaling pathway"]
["KIF18A",12.81918522,3.579870544,1.838186302,5.294959074,{"v":3.38e-10,"d":"3.38E-10"},{"v":3.46E-9,"d":"3.46E-09"},"ENSG00000121621","B2R6H3,Kinesin-like protein","-","PF00225,Kinesin motor domain","IPR027640,Kinesin-like protein;IPR019821,Kinesin motor domain, conserved site;IPR001752,Kinesin motor domain;IPR036961,Kinesin motor domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG5059,Kinesin-like protein;KOG0242,Kinesin-like protein","GO:0005874,cellular_component,microtubule;GO:0005524,molecular_function,ATP binding;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0003774,molecular_function,motor activity;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity","-"]
["UBE2D4",4.988023421,1.390466561,1.837452213,3.994205336,{"v":2.1e-06,"d":"2.10E-06"},{"v":9.28e-06,"d":"9.28E-06"},"ENSG00000078967","A0A1W4Z756,ubiquitin-conjugating enzyme E2 D4 isoform X1","XP_018599599.1,-","-","IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR023313,Ubiquitin-conjugating enzyme, active site;IPR000608,Ubiquitin-conjugating enzyme E2","-","GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","K06689,ko04120,Ubiquitin mediated proteolysis;K06689,ko04141,Protein processing in endoplasmic reticulum;K06689,ko04013,MAPK signaling pathway - fly"]
["SLC35F6",23.42956328,6.549909973,1.837384484,5.894735062,{"v":6.09e-12,"d":"6.09E-12"},{"v":9.14e-11,"d":"9.14E-11"},"ENSG00000213699","G3QN53,Solute carrier family 35 member F6","-","PF06027,Solute carrier family 35","-","-","-","-"]
["ZNF704",8.195919194,2.292421491,1.836994456,6.316927727,{"v":5.16e-13,"d":"5.16E-13"},{"v":9.98e-12,"d":"9.98E-12"},"ENSG00000164684","G3QZV4,Zinc finger protein 704","XP_018888127.1,-","-","IPR013087,Zinc finger C2H2-type","-","GO:0003676,molecular_function,nucleic acid binding;GO:0001158,molecular_function,enhancer sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0006357,biological_process,regulation of transcription by RNA polymerase II","-"]
["ZNF184",7.149664848,1.99410809,1.836400533,3.923410306,{"v":4.46e-06,"d":"4.46E-06"},{"v":1.84E-5,"d":"1.84E-05"},"ENSG00000096654","Q6ZND3,cDNA FLJ16197 fis, clone CTONG1000113, highly similar to ZINC FINGER PROTEIN 184","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["AVEN",3.283464398,0.906148908,1.835743072,2.179053117,0.00644454,0.012865895,"ENSG00000169857","H2Q934,Apoptosis, caspase activation inhibitor","XP_510277.3,cell death regulator Aven","-","IPR026187,Cell death regulator Aven","ENOG4111U7Z,-;ENOG410IKTA,-","GO:0043066,biological_process,negative regulation of apoptotic process;GO:0016020,cellular_component,membrane;GO:0005622,cellular_component,intracellular","-"]
["AC009121.1",76.10902092,21.00406699,1.835743072,2.179053117,0.00644454,0.012865895,"-","-","-","-","-","-","-","-"]
["IGFBP7",3.075908618,0.848869029,1.835743072,2.179053117,0.00644454,0.012865895,"ENSG00000163453","H2QPI9,Uncharacterized protein","XP_517274.3,-","PF13927,Immunoglobulin domain;PF07648,Kazal-type serine protease inhibitor domain;PF00219,Insulin-like growth factor binding protein","IPR000867,Insulin-like growth factor-binding protein, IGFBP;IPR002350,Kazal domain;IPR011390,Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR036058,Kazal domain superfamily;IPR003599,Immunoglobulin subtype;IPR007110,Immunoglobulin-like domain;IPR013783,Immunoglobulin-like fold","ENOG4111RFI,-;ENOG410IVG7,-","GO:0001558,biological_process,regulation of cell growth;GO:0031012,cellular_component,extracellular matrix;GO:0007155,biological_process,cell adhesion;GO:0005520,molecular_function,insulin-like growth factor binding;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space","-"]
["ZNF3",3.896377753,1.087378689,1.835231779,3.848918969,{"v":7.38e-06,"d":"7.38E-06"},{"v":2.89e-05,"d":"2.89E-05"},"ENSG00000166526","K7DF23,Zinc finger protein 3","XP_009452018.1,-;XP_003318679.1,zinc finger protein 3 isoform X2;XP_003318682.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["C5orf45",4.276294989,1.19557048,1.835147846,4.596384246,{"v":4.19e-08,"d":"4.19E-08"},{"v":2.69e-07,"d":"2.69E-07"},"ENSG00000161010","H2QS59,Uncharacterized protein","XP_001153552.2,UPF0544 protein C5orf45 homolog isoform X2","PF15749,MRN-interacting protein","IPR032739,MRN complex-interacting protein","ENOG410J2EG,-;ENOG411227Z,-","GO:1905168,biological_process,positive regulation of double-strand break repair via homologous recombination;GO:0045860,biological_process,positive regulation of protein kinase activity;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0007095,biological_process,mitotic G2 DNA damage checkpoint;GO:0071168,biological_process,protein localization to chromatin;GO:2001032,biological_process,regulation of double-strand break repair via nonhomologous end joining;GO:0010212,biological_process,response to ionizing radiation;GO:0030870,cellular_component,Mre11 complex;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","-"]
["XPNPEP3",2.083418864,0.581813094,1.833925248,3.770321154,{"v":6.8e-06,"d":"6.80E-06"},{"v":2.68e-05,"d":"2.68E-05"},"ENSG00000196236","H2QLR7,X-prolyl aminopeptidase","-","PF05195,Aminopeptidase P, N-terminal domain;PF00557,Metallopeptidase family M24","IPR036005,Creatinase/aminopeptidase-like;IPR007865,Aminopeptidase P, N-terminal;IPR000994,Peptidase M24;IPR029149,Creatinase/Aminopeptidase P/Spt16, N-terminal","KOG2414,Putative Xaa-Pro aminopeptidase;COG0006,Xaa-Pro aminopeptidase","GO:0016787,molecular_function,hydrolase activity;GO:0004177,molecular_function,aminopeptidase activity;GO:0016485,biological_process,protein processing;GO:0046872,molecular_function,metal ion binding;GO:0003094,biological_process,glomerular filtration;GO:0005739,cellular_component,mitochondrion;GO:0030145,molecular_function,manganese ion binding","-"]
["EPN2",13.85672094,3.885641418,1.833282194,6.258751031,{"v":9.92e-13,"d":"9.92E-13"},{"v":1.81e-11,"d":"1.81E-11"},"ENSG00000072134","H2NT01,Epsin 2","-","PF01417,NTH domain","IPR027319,Epsin-2, metazoa;IPR013809,ENTH  domain;IPR003903,Ubiquitin interacting motif;IPR008942,ENTH/VHS","ENOG410XSM0,-;KOG2056,Equilibrative nucleoside transporter protein","GO:0030128,cellular_component,clathrin coat of endocytic vesicle;GO:0045747,biological_process,positive regulation of Notch signaling pathway;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:1903671,biological_process,negative regulation of sprouting angiogenesis;GO:0030948,biological_process,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0045296,molecular_function,cadherin binding;GO:0006897,biological_process,endocytosis","-"]
["TTL",2.082983731,0.583179282,1.832752333,4.453442934,{"v":1.6E-7,"d":"1.60E-07"},{"v":8.95e-07,"d":"8.95E-07"},"ENSG00000114999","K7B4T7,Tubulin tyrosine ligase","XP_009441393.2,-","PF03133,Tubulin-tyrosine ligase family","IPR004344,Tubulin-tyrosine ligase/Tubulin polyglutamylase","ENOG410XQDM,-;KOG2157,Predicted tubulin-tyrosine ligase","GO:0004835,molecular_function,tubulin-tyrosine ligase activity;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0005623,cellular_component,cell;GO:0016874,molecular_function,ligase activity;GO:0018166,biological_process,C-terminal protein-tyrosinylation;GO:0090235,biological_process,regulation of metaphase plate congression;GO:0006464,biological_process,cellular protein modification process;GO:0045931,biological_process,positive regulation of mitotic cell cycle;GO:0030516,biological_process,regulation of axon extension","-"]
["TOX2",5.820462761,1.626625852,1.832455052,3.687134116,{"v":1.16e-05,"d":"1.16E-05"},{"v":4.34e-05,"d":"4.34E-05"},"ENSG00000124191","H2RE21,TOX high mobility group box family member 2","XP_016793436.1,-","PF00505,HMG (high mobility group) box","IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily","KOG0381,HMG box-containing protein;COG5648,Chromatin-associated proteins containing the HMG domain","GO:0003677,molecular_function,DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["KLF10",14.29625156,4.01086905,1.831428032,5.233485883,{"v":6.43e-10,"d":"6.43E-10"},{"v":6.19e-09,"d":"6.19E-09"},"ENSG00000155090","H2RBW8,Kruppel-like factor 10","XP_528205.2,Krueppel-like factor 10 isoform X1","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001046,molecular_function,core promoter sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0030282,biological_process,bone mineralization;GO:0035019,biological_process,somatic stem cell population maintenance;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0009267,biological_process,cellular response to starvation;GO:0045672,biological_process,positive regulation of osteoclast differentiation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0007623,biological_process,circadian rhythm","-"]
["CSPG4P10",2.448042735,0.684724391,1.830788382,3.598784302,{"v":2.69E-5,"d":"2.69E-05"},{"v":9.3e-05,"d":"9.30E-05"},"ENSG00000276710","K7BXA8,Chondroitin sulfate proteoglycan 4","-","PF00054,Laminin G domain;PF02210,Laminin G domain;PF16184,Cadherin-like","IPR001791,Laminin G domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily","KOG3597,Proteoglycan;ENOG410XQ29,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NFIX",2.788329221,0.779903471,1.830788382,3.598784302,{"v":2.69E-5,"d":"2.69E-05"},{"v":9.3e-05,"d":"9.30E-05"},"ENSG00000008441","A0A287B4C0,Nuclear factor 1","-","-","IPR020604,CTF transcription factor/nuclear factor 1, DNA-binding domain;IPR000647,CTF transcription factor/nuclear factor 1;IPR003619,MAD homology 1, Dwarfin-type;IPR019548,CTF transcription factor/nuclear factor 1, N-terminal;IPR019739,CTF transcription factor/nuclear factor 1, conserved site","-","GO:0003677,molecular_function,DNA binding;GO:0006260,biological_process,DNA replication;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","-"]
["RNPC3",0.691597918,0.190862645,1.830418085,1.905230356,0.023156585,0.039980573,"ENSG00000185946","H2QZU7,RNA-binding region","XP_009424947.1,-;XP_009424943.1,-;XP_003308296.1,RNA-binding protein 40 isoform X1","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR000504,RNA recognition motif domain;IPR034147,RBM40, RNA recognition motif 1;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily","KOG4206,Spliceosomal protein snRNP-U1A/U2B;ENOG410XQEY,-","GO:0005689,cellular_component,U12-type spliceosomal complex;GO:0097157,molecular_function,pre-mRNA intronic binding;GO:0003723,molecular_function,RNA binding;GO:0032502,biological_process,developmental process;GO:0003676,molecular_function,nucleic acid binding;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0030626,molecular_function,U12 snRNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["IFITM10",0.99272636,0.273966091,1.830418085,1.905230356,0.023156585,0.039980573,"ENSG00000244242","G3RA73,Interferon induced transmembrane protein 10","XP_018892224.1,interferon-induced transmembrane protein 10","PF04505,Interferon-induced transmembrane protein","IPR007593,CD225/Dispanin family","-","GO:0009607,biological_process,response to biotic stimulus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TREH",1.492521341,0.411896223,1.830418085,1.905230356,0.023156585,0.039980573,"ENSG00000118094","H2Q4W7,Trehalase","-","PF01204,Trehalase","IPR012341,Six-hairpin glycosidase-like superfamily;IPR008928,Six-hairpin glycosidase superfamily;IPR001661,Glycoside hydrolase, family 37;IPR018232,Glycoside hydrolase, family 37, conserved site","KOG0602,Neutral trehalase;COG1626,Neutral trehalase","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0016787,molecular_function,hydrolase activity;GO:0005991,biological_process,trehalose metabolic process;GO:0003824,molecular_function,catalytic activity;GO:0008152,biological_process,metabolic process;GO:0004555,molecular_function,alpha,alpha-trehalase activity","K01194,ko00500,Starch and sucrose metabolism"]
["ARL17A",0.957500586,0.264244714,1.830418085,1.905230356,0.023156585,0.039980573,"ENSG00000185829","A8K0M5,cDNA FLJ76374","NP_001107210.1,-;NP_001034172.3,ADP-ribosylation factor-like protein 17 isoform a","PF15840,ADP-ribosylation factor-like protein 17;PF00025,ADP-ribosylation factor family","IPR031687,ADP-ribosylation factor-like protein 17, C-terminal;IPR006689,Small GTPase superfamily, ARF/SAR type;IPR024156,Small GTPase superfamily, ARF type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1100,GTPase SAR1 and related small G proteins;KOG0070,GTP-binding ADP-ribosylation factor Arf1","GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular","-"]
["ZSCAN12",0.864277144,0.238517521,1.830418085,1.905230356,0.023156585,0.039980573,"ENSG00000158691","A8K187,cDNA FLJ75996, highly similar to Homo sapiens zinc finger protein 96","-","PF00096,Zinc finger, C2H2 type;PF02023,SCAN domain","IPR003309,SCAN domain;IPR013087,Zinc finger C2H2-type;IPR038269,SCAN domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["LURAP1L",2.2275811,0.61475318,1.830418085,1.905230356,0.023156585,0.039980573,"ENSG00000153714","H2QX05,Chromosome 9 open reading frame 150","XP_001145863.1,leucine rich adaptor protein 1-like","PF14854,Leucine rich adaptor protein","IPR037443,Leucine rich adaptor protein","ENOG410IR6S,-;ENOG411219V,-","GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling","-"]
["FGFR3",16.40705183,4.609249951,1.830111105,5.694736027,{"v":3.74e-11,"d":"3.74E-11"},{"v":4.72e-10,"d":"4.72E-10"},"ENSG00000068078","F7FZS3,Fibroblast growth factor receptor","-","PF07714,Protein tyrosine kinase;PF07679,Immunoglobulin I-set domain","IPR013783,Immunoglobulin-like fold;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR016248,Fibroblast growth factor receptor family;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR036179,Immunoglobulin-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR007110,Immunoglobulin-like domain;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0200,Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases","GO:0005783,cellular_component,endoplasmic reticulum;GO:0008543,biological_process,fibroblast growth factor receptor signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding;GO:1902178,biological_process,fibroblast growth factor receptor apoptotic signaling pathway;GO:0010518,biological_process,positive regulation of phospholipase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0017134,molecular_function,fibroblast growth factor binding;GO:0016310,biological_process,phosphorylation;GO:0042802,molecular_function,identical protein binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0042531,biological_process,positive regulation of tyrosine phosphorylation of STAT protein;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0016301,molecular_function,kinase activity;GO:0016740,molecular_function,transferase activity;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0043552,biological_process,positive regulation of phosphatidylinositol 3-kinase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0030133,cellular_component,transport vesicle;GO:0046777,biological_process,protein autophosphorylation;GO:0004714,molecular_function,transmembrane receptor protein tyrosine kinase activity;GO:0005007,molecular_function,fibroblast growth factor-activated receptor activity;GO:0005794,cellular_component,Golgi apparatus;GO:0043410,biological_process,positive regulation of MAPK cascade","-"]
["THAP7",14.18657346,3.98340416,1.82934414,4.760794004,{"v":1.77E-8,"d":"1.77E-08"},{"v":1.23E-7,"d":"1.23E-07"},"ENSG00000184436","G3SJI6,THAP domain containing 7","XP_004063122.1,-","PF05485,THAP domain","IPR038441,THAP-type zinc finger superfamily;IPR006612,THAP-type zinc finger;IPR026519,THAP domain-containing protein 7","-","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["PCDH1",33.14707093,9.325336062,1.829005721,6.981718191,{"v":2.35e-14,"d":"2.35E-14"},{"v":6.11e-13,"d":"6.11E-13"},"ENSG00000156453","H2RF32,Uncharacterized protein","XP_003310925.1,protocadherin-1 isoform X1","PF08374,Protocadherin;PF08266,Cadherin-like;PF00028,Cadherin domain","IPR013585,Protocadherin;IPR020894,Cadherin conserved site;IPR002126,Cadherin;IPR013164,Cadherin, N-terminal;IPR015919,Cadherin-like","ENOG410XPHP,-;ENOG410II7Q,-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["FRMD4B",2.803992509,0.786943128,1.828621453,4.237536538,{"v":6.04e-07,"d":"6.04E-07"},{"v":2.99e-06,"d":"2.99E-06"},"ENSG00000114541","G3QIE2,FERM domain containing 4B","XP_004035922.1,FERM domain-containing protein 4B","PF09379,RM N-terminal domain;PF09380,RM C-terminal PH-like domain;PF00373,RM central domain;PF11819,omain of unknown function (DUF3338)","IPR019748,FERM central domain;IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR019747,FERM conserved site;IPR011993,PH-like domain superfamily;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR021774,Domain of unknown function DUF3338;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR029071,Ubiquitin-like domain superfamily","-","GO:0090162,biological_process,establishment of epithelial cell polarity;GO:0001726,cellular_component,ruffle;GO:0005923,cellular_component,bicellular tight junction;GO:0005912,cellular_component,adherens junction;GO:0005737,cellular_component,cytoplasm;GO:0005856,cellular_component,cytoskeleton","-"]
["RP11-746M1.1",53.24007226,14.95289531,1.827362901,4.178056128,{"v":9.34e-07,"d":"9.34E-07"},{"v":4.43e-06,"d":"4.43E-06"},"-","-","-","-","-","-","-","-"]
["MBD5",1.536990551,0.432273674,1.826694539,4.634036585,{"v":4.89e-08,"d":"4.89E-08"},{"v":3.09e-07,"d":"3.09E-07"},"ENSG00000204406","E9PHH0,Methyl-CpG-binding domain protein 5","XP_016859971.1,methyl-CpG-binding domain protein 5 isoform X2","PF00855,PWWP domain","IPR001739,Methyl-CpG DNA binding;IPR000313,PWWP domain;IPR037385,Methyl-CpG-binding domain protein 5/6;IPR016177,DNA-binding domain superfamily","ENOG410XR1J,-;ENOG410IGJZ,-","GO:0030496,cellular_component,midbody;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["RSC1A1",13.83262982,3.888131495,1.825989226,4.115993534,{"v":1.07e-06,"d":"1.07E-06"},{"v":5.03e-06,"d":"5.03E-06"},"ENSG00000215695","H2RBH2,Regulator of solute carriers 1","-","-","-","-","-","-"]
["EGR1",11.12385002,3.132537716,1.824631398,4.542846244,{"v":7.5e-08,"d":"7.50E-08"},{"v":4.52e-07,"d":"4.52E-07"},"ENSG00000120738","G3QYK0,Early growth response protein","-","PF00096,Zinc finger, C2H2 type;PF11914,omain of unknown function (DUF3432);PF11928,omain of unknown function (DUF3446)","-","-","-","-"]
["SNRK",3.503566103,0.985665714,1.824483874,4.051112908,{"v":1.7E-6,"d":"1.70E-06"},{"v":7.69e-06,"d":"7.69E-06"},"ENSG00000163788","A0A024R2Y6,SNF related kinase, isoform CRA_a","NP_001094064.1,-;NP_060189.3,SNF-related serine/threonine-protein kinase isoform 1;XP_005265302.1,-","PF00069,Protein kinase domain","IPR015940,Ubiquitin-associated domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG4717,Serine/threonine protein kinase;ENOG410XR6N,-","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0000287,molecular_function,magnesium ion binding;GO:0005634,cellular_component,nucleus;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["CTD-2636A23.2",5.61079238,1.574674145,1.824116921,3.295083932,1.1585E-4,0.000345255,"-","-","-","-","-","-","-","-"]
["TRPC4AP",13.69113051,3.859643804,1.823843124,4.871337049,{"v":1.1e-08,"d":"1.10E-08"},{"v":8.07e-08,"d":"8.07E-08"},"ENSG00000100991","H2QK89,Transient receptor potential cation channel, subfamily C, member 4 associated protein","-","PF12463,Protein of unknown function (DUF3689)","IPR022162,Short transient receptor potential channel 4-associated protein","ENOG410ZAXR,-;ENOG410IH9D,-","GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0031464,cellular_component,Cul4A-RING E3 ubiquitin ligase complex","-"]
["RP11-793H13.10",8.650964401,2.436159443,1.82282696,3.983144412,{"v":2.74E-6,"d":"2.74E-06"},{"v":1.18e-05,"d":"1.18E-05"},"ENSG00000267281","K7ELQ4,Uncharacterized protein","-","PF00170,bZIP transcription factor","IPR013087,Zinc finger C2H2-type;IPR016378,Transcription factor cyclic AMP-dependent, CRE-BP1-type;IPR036236,Zinc finger C2H2 superfamily;IPR004827,Basic-leucine zipper domain","KOG1414,Transcriptional activator FOSB/c-Fos and related bZIP transcription factors;ENOG4111CH5,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity","-"]
["NCOA5",34.58658638,9.768848052,1.822820291,6.178406414,{"v":2.05e-12,"d":"2.05E-12"},3.43E-11,"ENSG00000124160","G3RCP3,Nuclear receptor coactivator 5","XP_004062341.1,-","-","IPR036621,Anticodon-binding domain superfamily","-","GO:0046627,biological_process,negative regulation of insulin receptor signaling pathway;GO:0015629,cellular_component,actin cytoskeleton;GO:0042593,biological_process,glucose homeostasis;GO:0003682,molecular_function,chromatin binding;GO:0005634,cellular_component,nucleus","-"]
["PSMC4",50.03873191,14.13880806,1.822329786,6.278184021,{"v":1.07e-12,"d":"1.07E-12"},{"v":1.93e-11,"d":"1.93E-11"},"ENSG00000013275","I3MJ99,Proteasome 26S subunit, ATPase 4","XP_005336482.1,-","PF00004,ATPase family associated with various cellular activities (AAA)","IPR035256,26S Proteasome regulatory subunit 6B;IPR003960,ATPase, AAA-type, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR005937,26S proteasome regulatory subunit P45-like;IPR003593,AAA+ ATPase domain;IPR003959,ATPase, AAA-type, core","KOG0727,26S proteasome regulatory complex, ATPase RPT3;COG1222,ATP-dependent 26S proteasome regulatory subunit","GO:0016787,molecular_function,hydrolase activity;GO:1901800,biological_process,positive regulation of proteasomal protein catabolic process;GO:0022624,cellular_component,proteasome accessory complex;GO:0000502,cellular_component,proteasome complex;GO:0030163,biological_process,protein catabolic process;GO:0005634,cellular_component,nucleus;GO:0005737,cellular_component,cytoplasm;GO:0036402,molecular_function,proteasome-activating ATPase activity;GO:0005829,cellular_component,cytosol;GO:0001824,biological_process,blastocyst development;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["MTDH",53.65239396,15.17577527,1.82150523,7.787773736,{"v":1.16e-15,"d":"1.16E-15"},{"v":4.16e-14,"d":"4.16E-14"},"ENSG00000147649","A0A024R9D2,Metadherin, isoform CRA_a","NP_848927.2,protein LYRIC","PF15686,Lysine-rich CEACAM1 co-isolated protein family","IPR031402,Protein LYRIC","ENOG410IIV9,-;ENOG410YF4D,-","GO:0070830,biological_process,bicellular tight junction assembly;GO:0005923,cellular_component,bicellular tight junction;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0005730,cellular_component,nucleolus;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0005783,cellular_component,endoplasmic reticulum;GO:0001650,cellular_component,fibrillar center;GO:0016324,cellular_component,apical plasma membrane;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0046581,cellular_component,intercellular canaliculus;GO:0016020,cellular_component,membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0016021,cellular_component,integral component of membrane","-"]
["GUSBP1",1.878805545,0.528102256,1.821081894,3.177464542,0.000219377,0.000614308,"ENSG00000283352","B3KTI7,cDNA FLJ38337 fis, clone FCBBF3026692, moderately similar to Homo sapiens WD repeat domain 70","-","PF02836,lycosyl hydrolases family 2, TIM barrel domain","IPR006103,Glycoside hydrolase family 2, catalytic domain","KOG0772,Uncharacterized conserved protein, contains WD40 repeat;ENOG410XP76,-","GO:0004553,molecular_function,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005975,biological_process,carbohydrate metabolic process","-"]
["LRRC14",2.089773117,0.587401874,1.821081894,3.177464542,0.000219377,0.000614308,"ENSG00000160959","H2PRI1,Leucine rich repeat containing 14","XP_009242470.1,-;XP_009242471.1,-","PF13516,Leucine Rich repeat","IPR001611,Leucine-rich repeat;IPR032675,Leucine-rich repeat domain superfamily;IPR026292,Leucine-rich repeat-containing protein 14","ENOG4111FCX,-;ENOG410IIBA,-","GO:0005737,cellular_component,cytoplasm;GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0034122,biological_process,negative regulation of toll-like receptor signaling pathway;GO:0019900,molecular_function,kinase binding","-"]
["IL17RD",2.309778633,0.651145848,1.820994377,3.91177734,{"v":4.46e-06,"d":"4.46E-06"},{"v":1.84E-5,"d":"1.84E-05"},"ENSG00000144730","A0A096NRW0,Interleukin 17 receptor D","XP_017810853.1,-;XP_017810854.1,-","PF08357,SEFIR domain;PF16742,N-terminus of interleukin 17 receptor D","IPR013568,SEFIR domain;IPR035897,Toll/interleukin-1 receptor homology (TIR) domain superfamily;IPR031951,Interleukin 17 receptor D, N-terminal","-","GO:0005794,cellular_component,Golgi apparatus;GO:0005654,cellular_component,nucleoplasm","-"]
["PRKAG2",3.100369849,0.87506558,1.818956624,3.836651405,{"v":9.7e-06,"d":"9.70E-06"},{"v":3.7e-05,"d":"3.70E-05"},"ENSG00000106617","H2R4U8,Protein kinase, AMP-activated, gamma 2 non-catalytic subunit","-","PF00571,CBS domain","IPR000644,CBS domain","KOG1764,5'-AMP-activated protein kinase, gamma subunit;COG0517,FOG: CBS domain","-","-"]
["MYLIP",9.551644485,2.700819692,1.818015525,4.285706233,{"v":3.95e-07,"d":"3.95E-07"},{"v":2.02e-06,"d":"2.02E-06"},"ENSG00000007944","H2R0D4,Myosin regulatory light chain interacting protein","-","PF09379,RM N-terminal domain;PF13920,Zinc finger, C3HC4 type (RING finger);PF00373,RM central domain;PF09380,RM C-terminal PH-like domain","IPR019748,FERM central domain;IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR018979,FERM, N-terminal;IPR011993,PH-like domain superfamily;IPR001841,Zinc finger, RING-type;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000798,Ezrin/radixin/moesin-like;IPR029071,Ubiquitin-like domain superfamily","ENOG410IG7I,-;ENOG410XRZN,-","GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0045732,biological_process,positive regulation of protein catabolic process;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016567,biological_process,protein ubiquitination;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0032803,biological_process,regulation of low-density lipoprotein particle receptor catabolic process;GO:0031032,biological_process,actomyosin structure organization;GO:0010989,biological_process,negative regulation of low-density lipoprotein particle clearance;GO:0031648,biological_process,protein destabilization;GO:0005856,cellular_component,cytoskeleton;GO:0007399,biological_process,nervous system development;GO:0010977,biological_process,negative regulation of neuron projection development;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0005622,cellular_component,intracellular;GO:0042632,biological_process,cholesterol homeostasis;GO:0005200,molecular_function,structural constituent of cytoskeleton","-"]
["F3",124.5530084,35.33066712,1.817416845,7.850951842,1.15E-15,{"v":4.11e-14,"d":"4.11E-14"},"ENSG00000117525","B2R6M5,Tissue factor","-","PF01108,Tissue factor;PF09294,Interferon-alpha/beta receptor, fibronectin type III","IPR003961,Fibronectin type III;IPR036116,Fibronectin type III superfamily;IPR001187,Tissue factor;IPR030472,Tissue factor, conserved site;IPR015373,Interferon/interleukin receptor domain;IPR013783,Immunoglobulin-like fold","ENOG4111MW4,-;ENOG410IYA1,-","GO:0016021,cellular_component,integral component of membrane;GO:0007596,biological_process,blood coagulation;GO:0016020,cellular_component,membrane","-"]
["PIP4K2C",8.421593513,2.383729215,1.816358252,4.228231328,{"v":7.71e-07,"d":"7.71E-07"},{"v":3.73e-06,"d":"3.73E-06"},"ENSG00000166908","G3RVX7,Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma","XP_004053495.1,phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1;XP_018894820.1,-","PF01504,Phosphatidylinositol-4-phosphate 5-Kinase","IPR023610,Phosphatidylinositol-4-phosphate 5-kinase;IPR002498,Phosphatidylinositol-4-phosphate 5-kinase, core;IPR027484,Phosphatidylinositol-4-phosphate 5-kinase, N-terminal;IPR027483,Phosphatidylinositol-4-phosphate 5-kinase, C-terminal","-","GO:0016301,molecular_function,kinase activity;GO:2000786,biological_process,positive regulation of autophagosome assembly;GO:0000166,molecular_function,nucleotide binding;GO:0010506,biological_process,regulation of autophagy;GO:0016310,biological_process,phosphorylation;GO:0016307,molecular_function,phosphatidylinositol phosphate kinase activity;GO:0046488,biological_process,phosphatidylinositol metabolic process;GO:0005776,cellular_component,autophagosome;GO:0016740,molecular_function,transferase activity;GO:0042802,molecular_function,identical protein binding;GO:0005524,molecular_function,ATP binding;GO:0046854,biological_process,phosphatidylinositol phosphorylation","K00920,ko04070,Phosphatidylinositol signaling system;K00920,ko00562,Inositol phosphate metabolism;K00920,ko04810,Regulation of actin cytoskeleton"]
["TOX4",8.472347589,2.402834458,1.815939329,5.305175024,{"v":6.6E-10,"d":"6.60E-10"},{"v":6.34E-9,"d":"6.34E-09"},"ENSG00000092203","G3RFD2,TOX high mobility group box family member 4","XP_018865028.1,-","PF00505,HMG (high mobility group) box","IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily;IPR037985,TOX high mobility group box family member 4","-","GO:0072357,cellular_component,PTW/PP1 phosphatase complex;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["FARP1",2.92990739,0.83209222,1.814861122,6.111735153,{"v":3.14e-12,"d":"3.14E-12"},5.05E-11,"ENSG00000152767","C9JME2,FERM, ARHGEF and pleckstrin domain-containing protein 1","NP_001273768.1,FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 3;XP_011519348.1,-","PF09380,RM C-terminal PH-like domain;PF00621,RhoGEF domain;PF09379,RM N-terminal domain;PF08736,RM adjacent (FA);PF00373,RM central domain;PF00169,PH domain","IPR019748,FERM central domain;IPR014847,FERM adjacent (FA);IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR019747,FERM conserved site;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR035899,Dbl homology (DH) domain superfamily;IPR000798,Ezrin/radixin/moesin-like;IPR029071,Ubiquitin-like domain superfamily;IPR000219,Dbl homology (DH) domain","KOG3531,Rho guanine nucleotide exchange factor CDEP;ENOG410XP7Q,-","GO:0030425,cellular_component,dendrite;GO:0048813,biological_process,dendrite morphogenesis;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0065009,biological_process,regulation of molecular function;GO:0048365,molecular_function,Rac GTPase binding;GO:0005856,cellular_component,cytoskeleton;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0030676,molecular_function,Rac guanyl-nucleotide exchange factor activity;GO:0005829,cellular_component,cytosol;GO:0031234,cellular_component,extrinsic component of cytoplasmic side of plasma membrane;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0007416,biological_process,synapse assembly","-"]
["STRIP1",7.848587501,2.228396661,1.814259443,5.248701938,{"v":8.31e-10,"d":"8.31E-10"},{"v":7.77e-09,"d":"7.77E-09"},"ENSG00000143093","H2PZL9,Family with sequence similarity 40, member A","-","PF07923,N1221-like protein;PF11882,omain of unknown function (DUF3402)","IPR021819,Far11/STRP, C-terminal;IPR012486,Far11/STRP, N-terminal","ENOG410XRAB,-;KOG3680,Uncharacterized conserved protein","GO:0019901,molecular_function,protein kinase binding;GO:0022604,biological_process,regulation of cell morphogenesis;GO:0030866,biological_process,cortical actin cytoskeleton organization;GO:0005829,cellular_component,cytosol;GO:0017048,molecular_function,Rho GTPase binding;GO:0005634,cellular_component,nucleus","-"]
["CCSER2",8.625689038,2.450474482,1.813858241,5.574213572,1.16E-10,{"v":1.3e-09,"d":"1.30E-09"},"ENSG00000107771","H2R1U7,Uncharacterized protein","-","-","-","-","-","-"]
["C19orf57",2.720897498,0.767961199,1.812980633,2.908118439,0.000610301,0.001546949,"ENSG00000132016","H2QFJ2,Uncharacterized protein","XP_001171304.3,uncharacterized protein C19orf57 homolog isoform X2","PF15710,omain of unknown function (DUF4671)","IPR031441,Protein of unknown function DUF4671","ENOG410IV9I,-;ENOG41119U1,-","-","-"]
["MAGI1",3.465381123,0.984481121,1.812484613,4.747909259,{"v":2.17e-08,"d":"2.17E-08"},{"v":1.48E-7,"d":"1.48E-07"},"ENSG00000151276","K7DRB4,Membrane associated guanylate kinase, WW and PDZ domain containing 1","-","PF00397,WW domain;PF00625,uanylate kinase;PF00595,PDZ domain (Also known as DHR or GLGF);PF16663,Unstructured region on MAGI;PF16666,Unstructured region on MAGI","IPR001202,WW domain;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR030033,Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1;IPR020590,Guanylate kinase, conserved site;IPR008144,Guanylate kinase-like domain;IPR008145,Guanylate kinase/L-type calcium channel beta subunit;IPR036020,WW domain superfamily","KOG3209,WW domain-containing protein;COG5021,Ubiquitin-protein ligase","GO:0016301,molecular_function,kinase activity;GO:0032947,molecular_function,protein-containing complex scaffold activity;GO:0005923,cellular_component,bicellular tight junction;GO:0016310,biological_process,phosphorylation","-"]
["ABAT",3.314304162,0.941561624,1.811712978,4.437426481,{"v":2e-07,"d":"2.00E-07"},{"v":1.1e-06,"d":"1.10E-06"},"ENSG00000183044","H3BNQ7,4-aminobutyrate aminotransferase, mitochondrial","-","PF00202,Aminotransferase class-III","IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR015422,Pyridoxal phosphate-dependent transferase domain 1;IPR004631,4-aminobutyrate aminotransferase, eukaryotic;IPR015424,Pyridoxal phosphate-dependent transferase;IPR005814,Aminotransferase class-III","KOG1405,4-aminobutyrate aminotransferase;COG0160,4-aminobutyrate aminotransferase and related aminotransferases","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0003824,molecular_function,catalytic activity;GO:0003867,molecular_function,4-aminobutyrate transaminase activity;GO:0009448,biological_process,gamma-aminobutyric acid metabolic process;GO:0005739,cellular_component,mitochondrion;GO:0008483,molecular_function,transaminase activity","-"]
["TCF19",11.07431429,3.148829037,1.811146343,4.706509619,{"v":3.73e-08,"d":"3.73E-08"},{"v":2.42e-07,"d":"2.42E-07"},"ENSG00000137310","A0A1U9X8M7,TCF19","NP_009040.2,-;NP_001070979.1,transcription factor 19;NP_001305837.1,-","-","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR000253,Forkhead-associated (FHA) domain;IPR008984,SMAD/FHA domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR019786,Zinc finger, PHD-type, conserved site","-","GO:0046872,molecular_function,metal ion binding","-"]
["GMEB2",9.786970084,2.78447797,1.810749121,4.933018241,{"v":7.29e-09,"d":"7.29E-09"},{"v":5.53e-08,"d":"5.53E-08"},"ENSG00000101216","K7DHI4,Glucocorticoid modulatory element binding protein 2","-","PF01342,SAND domain","IPR000770,SAND domain;IPR010919,SAND-like domain superfamily;IPR024830,Glucocorticoid modulatory element-binding protein 1/2","-","GO:0003677,molecular_function,DNA binding;GO:0003713,molecular_function,transcription coactivator activity;GO:0005634,cellular_component,nucleus;GO:1903506,biological_process,regulation of nucleic acid-templated transcription","-"]
["MYO1E",9.596456563,2.734726754,1.809680531,5.836512904,{"v":2e-11,"d":"2.00E-11"},{"v":2.7E-10,"d":"2.70E-10"},"ENSG00000157483","Q4KMR3,MYO1E variant protein","NP_004989.2,unconventional myosin-Ie","PF00018,SH3 domain;PF06017,Unconventional myosin tail, actin- and lipid-binding;PF00063,Myosin head (motor domain)","IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR010926,Class I myosin tail homology domain;IPR036072,Class I myosin, motor domain;IPR036028,SH3-like domain superfamily;IPR036961,Kinesin motor domain superfamily;IPR000048,IQ motif, EF-hand binding site;IPR001452,SH3 domain;IPR035507,Unconventional myosin-Ie/If, SH3 domain","COG5022,Myosin heavy chain;KOG0164,Myosin class I heavy chain","GO:0001570,biological_process,vasculogenesis;GO:0005912,cellular_component,adherens junction;GO:0016459,cellular_component,myosin complex;GO:0008017,molecular_function,microtubule binding;GO:0005524,molecular_function,ATP binding;GO:0035166,biological_process,post-embryonic hemopoiesis;GO:0005903,cellular_component,brush border;GO:0048008,biological_process,platelet-derived growth factor receptor signaling pathway;GO:0001822,biological_process,kidney development;GO:0030097,biological_process,hemopoiesis;GO:0003094,biological_process,glomerular filtration;GO:0003779,molecular_function,actin binding;GO:0007018,biological_process,microtubule-based movement;GO:0003774,molecular_function,motor activity;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity;GO:0005911,cellular_component,cell-cell junction;GO:0032836,biological_process,glomerular basement membrane development;GO:0001701,biological_process,in utero embryonic development;GO:0005737,cellular_component,cytoplasm;GO:0006807,biological_process,nitrogen compound metabolic process;GO:0072015,biological_process,glomerular visceral epithelial cell development","-"]
["MPZL1",11.21964755,3.198299294,1.80908174,5.699186425,{"v":5.35e-11,"d":"5.35E-11"},{"v":6.48e-10,"d":"6.48E-10"},"ENSG00000197965","A8K5D4,Myelin protein zero-like 1, isoform CRA_b","NP_003944.1,myelin protein zero-like protein 1 isoform a precursor","PF07686,Immunoglobulin V-set domain","IPR007110,Immunoglobulin-like domain;IPR000920,Myelin P0 protein-related;IPR029870,Myelin protein zero-like protein 1;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR013106,Immunoglobulin V-set domain","ENOG4111MDZ,-;ENOG410IVXC,-","GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0007165,biological_process,signal transduction;GO:0005887,cellular_component,integral component of plasma membrane","K06770,ko04514,Cell adhesion molecules (CAMs)"]
["FBXO5",9.602484351,2.735515325,1.808215366,4.619943428,{"v":7.48e-08,"d":"7.48E-08"},{"v":4.51E-7,"d":"4.51E-07"},"ENSG00000112029","B2RB17,cDNA, FLJ95258, highly similar to Homo sapiens F-box protein 5","-","PF00646,-box domain","IPR001810,F-box domain","ENOG410IJ4T,-;ENOG4111MJS,-","-","-"]
["GDA",2.914174354,0.829107908,1.808051924,3.971994954,{"v":3.57e-06,"d":"3.57E-06"},{"v":1.5E-5,"d":"1.50E-05"},"ENSG00000119125","G3QZN7,Guanine deaminase","XP_018889722.1,guanine deaminase isoform X2","PF01979,Amidohydrolase family","IPR014311,Guanine deaminase;IPR006680,Amidohydrolase-related;IPR032466,Metal-dependent hydrolase;IPR011059,Metal-dependent hydrolase, composite domain superfamily","-","GO:0008892,molecular_function,guanine deaminase activity;GO:0006147,biological_process,guanine catabolic process;GO:0016810,molecular_function,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0016787,molecular_function,hydrolase activity;GO:0008270,molecular_function,zinc ion binding","-"]
["ZNF689",3.882493359,1.102978656,1.807865893,3.488888692,{"v":6.44e-05,"d":"6.44E-05"},0.000203574,"ENSG00000156853","H2QAY2,Uncharacterized protein","XP_003315111.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["RMND1",6.804589077,1.93311767,1.807865893,3.488888692,{"v":6.44e-05,"d":"6.44E-05"},0.000203574,"ENSG00000155906","H2QTX1,Uncharacterized protein","-","PF02582,Uncharacterised ACR, YagE family COG1723","-","-","-","-"]
["RP5-1024G6.2",7.54763298,2.13635498,1.807404329,2.751386273,0.001255385,0.002969706,"ENSG00000236723","A0A1B0GTM0,Carnitine O-palmitoyltransferase 2, mitochondrial","-","PF00755,Choline/Carnitine o-acyltransferase","IPR000542,Acyltransferase ChoActase/COT/CPT","-","GO:0016746,molecular_function,transferase activity, transferring acyl groups","-"]
["PDSS2",2.358875615,0.667678951,1.807404329,2.751386273,0.001255385,0.002969706,"ENSG00000164494","B2RE48,cDNA, FLJ96928, highly similar to Homo sapiens candidate tumor suppressor protein","-","PF00348,Polyprenyl synthetase","IPR008949,Isoprenoid synthase domain superfamily;IPR000092,Polyprenyl synthetase","KOG0776,Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase;COG0142,Geranylgeranyl pyrophosphate synthase","GO:0008299,biological_process,isoprenoid biosynthetic process;GO:0016740,molecular_function,transferase activity","-"]
["TUG1_3",208.4038406,59.44948582,1.807130502,5.031500989,{"v":4.8E-9,"d":"4.80E-09"},{"v":3.78e-08,"d":"3.78E-08"},"ENSG00000276965","A0A024R1L7,HCG41307, isoform CRA_a","-","-","-","-","-","-"]
["TNFRSF21",85.47244172,24.42664904,1.806599593,7.633567592,3.13E-15,1.01E-13,"ENSG00000146072","A0A024RD71,Tumor necrosis factor receptor superfamily, member 21, isoform CRA_b","NP_055267.1,tumor necrosis factor receptor superfamily member 21 precursor","PF00531,eath domain;PF00020,TNFR/NGFR cysteine-rich region","IPR034034,Tumor necrosis factor receptor 21, N-terminal;IPR022330,Tumour necrosis factor receptor 21;IPR011029,Death-like domain superfamily;IPR000488,Death domain;IPR034037,Tumor necrosis factor receptor 21, death domain;IPR001368,TNFR/NGFR cysteine-rich region;IPR011641,Tyrosine-protein kinase ephrin type A/B receptor-like","ENOG410YYKW,-;ENOG410IHQ6,-","GO:0051402,biological_process,neuron apoptotic process;GO:0031226,cellular_component,intrinsic component of plasma membrane;GO:0006959,biological_process,humoral immune response;GO:0002250,biological_process,adaptive immune response;GO:0048713,biological_process,regulation of oligodendrocyte differentiation;GO:0030424,cellular_component,axon;GO:0016020,cellular_component,membrane;GO:0042552,biological_process,myelination;GO:2001180,biological_process,negative regulation of interleukin-10 secretion;GO:0016021,cellular_component,integral component of membrane;GO:0097252,biological_process,oligodendrocyte apoptotic process;GO:2000663,biological_process,negative regulation of interleukin-5 secretion;GO:0042130,biological_process,negative regulation of T cell proliferation;GO:2000666,biological_process,negative regulation of interleukin-13 secretion;GO:0030889,biological_process,negative regulation of B cell proliferation;GO:0001783,biological_process,B cell apoptotic process;GO:0007165,biological_process,signal transduction;GO:0050852,biological_process,T cell receptor signaling pathway","K05157,ko04060,Cytokine-cytokine receptor interaction"]
["KANK2",14.11454647,4.032516868,1.806279491,6.135688697,{"v":3e-12,"d":"3.00E-12"},{"v":4.87e-11,"d":"4.87E-11"},"ENSG00000197256","K7BNV2,KN motif and ankyrin repeat domains 2","XP_016790549.1,KN motif and ankyrin repeat domain-containing protein 2 isoform X1;XP_016790554.1,-;XP_016790551.1,-;XP_016790552.1,-;XP_016790553.1,-;XP_016790550.1,-","PF12796,Ankyrin repeats (3 copies);PF12075,KN motif;PF13637,Ankyrin repeats (many copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR021939,Kank N-terminal motif;IPR036770,Ankyrin repeat-containing domain superfamily","-","-","-"]
["CAMK2G",15.72560549,4.494498583,1.80572049,6.120050554,{"v":3.82e-12,"d":"3.82E-12"},{"v":6.04e-11,"d":"6.04E-11"},"ENSG00000148660","A0A0A0MT11,Calcium/calmodulin-dependent protein kinase type II subunit gamma","-","PF00069,Protein kinase domain;PF08332,Calcium/calmodulin dependent protein kinase II association domain","IPR008271,Serine/threonine-protein kinase, active site;IPR032710,NTF2-like domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR013543,Calcium/calmodulin-dependent protein kinase II, association-domain;IPR000719,Protein kinase domain","-","GO:0005516,molecular_function,calmodulin binding;GO:0006468,biological_process,protein phosphorylation;GO:0004683,molecular_function,calmodulin-dependent protein kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["AASDHPPT",3.53329021,1.006890742,1.805421925,3.900046296,{"v":5.84E-6,"d":"5.84E-06"},{"v":2.34E-5,"d":"2.34E-05"},"ENSG00000149313","H2Q4P2,Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase","XP_508734.3,-","PF01648,4'-phosphopantetheinyl transferase superfamily","IPR008278,4'-phosphopantetheinyl transferase domain;IPR037143,4'-phosphopantetheinyl transferase domain superfamily","COG2091,Phosphopantetheinyl transferase;KOG0945,Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase","GO:0019878,biological_process,lysine biosynthetic process via aminoadipic acid;GO:0000287,molecular_function,magnesium ion binding;GO:0008897,molecular_function,holo-[acyl-carrier-protein] synthase activity;GO:0016740,molecular_function,transferase activity","-"]
["ANXA7",45.21865101,12.93709619,1.804447234,6.396349349,{"v":8.96e-13,"d":"8.96E-13"},{"v":1.65e-11,"d":"1.65E-11"},"ENSG00000138279","B2R657,Annexin","NP_004025.1,annexin A7 isoform 2","PF00191,Annexin","IPR018502,Annexin repeat;IPR013286,Annexin A7;IPR001464,Annexin;IPR037104,Annexin superfamily;IPR018252,Annexin repeat, conserved site;IPR034309,Annexin A7, chordates","ENOG410XPUN,-;KOG0819,Annexin","GO:0005544,molecular_function,calcium-dependent phospholipid binding;GO:0005509,molecular_function,calcium ion binding","-"]
["PRELID2",2.783253796,0.792488332,1.804015447,3.386819869,{"v":6.25e-05,"d":"6.25E-05"},0.000198637,"ENSG00000186314","H2QRQ0,Uncharacterized protein","XP_001155985.1,-;XP_009448157.1,-","PF04707,PRELI-like family","IPR037365,Slowmo/Ups family;IPR006797,PRELI/MSF1 domain","ENOG4111WVY,-;ENOG410IIHT,-","GO:0015914,biological_process,phospholipid transport;GO:1990050,molecular_function,phosphatidic acid transporter activity;GO:0005739,cellular_component,mitochondrion;GO:0005758,cellular_component,mitochondrial intermembrane space","-"]
["NFAT5",8.513295862,2.437347741,1.803519581,6.504894866,{"v":4.22e-13,"d":"4.22E-13"},{"v":8.4e-12,"d":"8.40E-12"},"ENSG00000102908","K7DKR3,Nuclear factor of activated T-cells 5, tonicity-responsive","XP_016785572.1,nuclear factor of activated T-cells 5 isoform X1","PF00554,Rel homology DNA-binding domain;PF16179,Rel homology dimerisation domain","IPR015646,Nuclear factor of activated T-cells 5;IPR011539,Rel homology domain (RHD), DNA-binding domain;IPR008967,p53-like transcription factor, DNA-binding;IPR032397,Rel homology dimerisation domain;IPR008366,Nuclear factor of activated T cells (NFAT);IPR037059,Rel homology domain (RHD), DNA-binding domain superfamily;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set;IPR002909,IPT domain","ENOG41118Z9,-;ENOG410IGY4,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001816,biological_process,cytokine production;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005829,cellular_component,cytosol;GO:0010628,biological_process,positive regulation of gene expression;GO:0070884,biological_process,regulation of calcineurin-NFAT signaling cascade;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-512M8.5",52.45207721,15.02386975,1.80288563,6.550428927,{"v":3.7e-13,"d":"3.70E-13"},{"v":7.46e-12,"d":"7.46E-12"},"ENSG00000256861","H3BMM5,Uncharacterized protein","-","PF00995,Sec1 family","IPR027121,Vacuolar protein sorting-associated protein 33;IPR027482,Sec1-like, domain 2;IPR036045,Sec1-like superfamily;IPR001619,Sec1-like protein","COG5158,Proteins involved in synaptic transmission and general secretion, Sec1 family;KOG1302,Vacuolar sorting protein VPS33/slp1 (Sec1 family)","GO:0016192,biological_process,vesicle-mediated transport;GO:0006904,biological_process,vesicle docking involved in exocytosis","-"]
["CCNB1",72.40770654,20.75116423,1.802283851,6.908986141,{"v":7.54e-14,"d":"7.54E-14"},1.76E-12,"ENSG00000134057","H2QR05,Cyclin B1","XP_517728.3,G2/mitotic-specific cyclin-B1","PF02984,Cyclin, C-terminal domain;PF00134,Cyclin, N-terminal domain","IPR004367,Cyclin, C-terminal domain;IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","COG5024,Cyclin;KOG0653,Cyclin B and related kinase-activating proteins","GO:2000775,biological_process,histone H3-S10 phosphorylation involved in chromosome condensation;GO:0019901,molecular_function,protein kinase binding;GO:0045931,biological_process,positive regulation of mitotic cell cycle;GO:0005634,cellular_component,nucleus;GO:1905448,biological_process,positive regulation of mitochondrial ATP synthesis coupled electron transport;GO:0016301,molecular_function,kinase activity;GO:0048146,biological_process,positive regulation of fibroblast proliferation;GO:0005737,cellular_component,cytoplasm;GO:0097125,cellular_component,cyclin B1-CDK1 complex;GO:0090266,biological_process,regulation of mitotic cell cycle spindle assembly checkpoint;GO:0005759,cellular_component,mitochondrial matrix;GO:0010971,biological_process,positive regulation of G2/M transition of mitotic cell cycle;GO:0005813,cellular_component,centrosome;GO:0045787,biological_process,positive regulation of cell cycle;GO:0005829,cellular_component,cytosol;GO:0045737,biological_process,positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0005113,molecular_function,patched binding;GO:0044389,molecular_function,ubiquitin-like protein ligase binding;GO:0007080,biological_process,mitotic metaphase plate congression;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000942,cellular_component,condensed nuclear chromosome outer kinetochore;GO:0051987,biological_process,positive regulation of attachment of spindle microtubules to kinetochore;GO:0001701,biological_process,in utero embryonic development;GO:0000922,cellular_component,spindle pole;GO:0061575,molecular_function,cyclin-dependent protein serine/threonine kinase activator activity;GO:0007052,biological_process,mitotic spindle organization","K05868,ko04914,Progesterone-mediated oocyte maturation;K05868,ko04068,FoxO signaling pathway;K05868,ko04115,p53 signaling pathway;K05868,ko04110,Cell cycle"]
["ANKHD1-EIF4EBP3",15.6638181,4.489723095,1.802044813,6.854834287,{"v":9.44e-14,"d":"9.44E-14"},{"v":2.16e-12,"d":"2.16E-12"},"ENSG00000254996","G3QDG6,Uncharacterized protein","-","PF12796,Ankyrin repeats (3 copies);PF00013,KH domain;PF13606,Ankyrin repeat","IPR004088,K Homology domain, type 1;IPR004087,K Homology domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR036612,K Homology domain, type 1 superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["MCM6",13.60869215,3.898860808,1.801200118,5.210285509,{"v":1.49E-9,"d":"1.49E-09"},{"v":1.32e-08,"d":"1.32E-08"},"ENSG00000076003","K7BMV9,DNA helicase","XP_001154732.2,-","PF00493,MCM2/3/5 family;PF17207,MCM OB domain;PF14551,MCM N-terminal domain","IPR018525,Mini-chromosome maintenance, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR008049,DNA replication licensing factor Mcm6;IPR001208,MCM domain;IPR033762,MCM OB domain;IPR031327,Mini-chromosome maintenance protein;IPR027925,MCM N-terminal domain;IPR012340,Nucleic acid-binding, OB-fold","KOG0480,DNA replication licensing factor, MCM6 component;COG1241,Predicted ATPase involved in replication control, Cdc46/Mcm family","GO:0003697,molecular_function,single-stranded DNA binding;GO:0004386,molecular_function,helicase activity;GO:0003677,molecular_function,DNA binding;GO:0006270,biological_process,DNA replication initiation;GO:0042555,cellular_component,MCM complex;GO:0006260,biological_process,DNA replication;GO:0004003,molecular_function,ATP-dependent DNA helicase activity;GO:0005524,molecular_function,ATP binding;GO:0003678,molecular_function,DNA helicase activity;GO:0016787,molecular_function,hydrolase activity;GO:0006268,biological_process,DNA unwinding involved in DNA replication;GO:0042802,molecular_function,identical protein binding;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K02542,ko04113,Meiosis - yeast;K02542,ko04111,Cell cycle - yeast;K02542,ko04110,Cell cycle;K02542,ko03030,DNA replication"]
["C17orf53",2.686737085,0.763275912,1.800226698,2.575045544,0.002660733,0.005829703,"ENSG00000125319","H2QD64,Uncharacterized protein","-","PF15072,omain of unknown function (DUF4539)","IPR028045,Protein of unknown function DUF4539","ENOG410IFHD,-;ENOG4111NPV,-","-","-"]
["DIEXF",5.835807348,1.673685677,1.799866856,5.319660619,7.19E-10,{"v":6.85e-09,"d":"6.85E-09"},"ENSG00000117597","A8K0P8,cDNA FLJ78223","-","PF06862,Utp25, U3 small nucleolar RNA-associated SSU processome protein 25","IPR010678,Digestive organ expansion factor, predicted;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG2340,Uncharacterized conserved protein;ENOG410XP00,-","GO:0005634,cellular_component,nucleus","-"]
["DTX4",2.268229319,0.647556216,1.799515827,3.276839568,0.000159262,4.61228E-4,"ENSG00000110042","H2Q3Q7,Deltex E3 ubiquitin ligase 4","XP_009438753.1,E3 ubiquitin-protein ligase DTX4","PF02825,WWE domain;PF00097,Zinc finger, C3HC4 type (RING finger)","IPR037197,WWE domain superfamily;IPR004170,WWE domain;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR018957,Zinc finger, C3HC4 RING-type;IPR018123,WWE domain, subgroup","ENOG410IEMS,-;ENOG4111EY2,-","GO:0046872,molecular_function,metal ion binding;GO:0008270,molecular_function,zinc ion binding","K06058,ko04330,Notch signaling pathway"]
["RASSF5",4.425146056,1.268192806,1.798956559,4.377456543,{"v":2.79E-7,"d":"2.79E-07"},{"v":1.48E-6,"d":"1.48E-06"},"ENSG00000266094","A8K5F3,cDNA FLJ75466, highly similar to Homo sapiens Ras association","NP_872605.1,ras association domain-containing protein 5 isoform B;NP_872604.1,ras association domain-containing protein 5 isoform A","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF00788,Ras association (RalGDS/AF-6) domain;PF16517,Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain","IPR011524,SARAH domain;IPR000159,Ras-associating (RA) domain;IPR033614,C-terminal RASSF family;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR029071,Ubiquitin-like domain superfamily;IPR033623,Ras association domain-containing protein 5","ENOG410IPAE,-;ENOG4111HS2,-","GO:0017016,molecular_function,Ras GTPase binding;GO:0035556,biological_process,intracellular signal transduction;GO:0042981,biological_process,regulation of apoptotic process;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular;GO:0007165,biological_process,signal transduction","K08015,ko05223,Non-small cell lung cancer;K08015,ko04015,Rap1 signaling pathway;K08015,ko05200,Pathways in cancer;K08015,ko04014,Ras signaling pathway;K08015,ko04670,Leukocyte transendothelial migration"]
["MED21",11.34269925,3.252242631,1.798886254,4.612843514,{"v":9.25e-08,"d":"9.25E-08"},{"v":5.47e-07,"d":"5.47E-07"},"ENSG00000152944","F5H872,Mediator of RNA polymerase II transcription subunit 21","-","PF11221,Subunit 21 of Mediator complex","IPR021384,Mediator complex, subunit Med21;IPR037212,Mediator complex, subunit Med7/Med21-like","KOG1510,RNA polymerase II holoenzyme and mediator subcomplex, subunit SURB7/SRB7;ENOG4111I75,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0016592,cellular_component,mediator complex;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["KDM2B",3.413825339,0.980383949,1.797339956,4.957320393,{"v":6.55e-09,"d":"6.55E-09"},{"v":5.03E-8,"d":"5.03E-08"},"ENSG00000089094","H2Q729,Lysine","XP_001164996.1,lysine-specific demethylase 2B isoform X3","PF00646,-box domain;PF16866,PHD-finger;PF02008,CXXC zinc finger domain;PF13621,Cupin-like domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR002857,Zinc finger, CXXC-type;IPR032675,Leucine-rich repeat domain superfamily;IPR006553,Leucine-rich repeat, cysteine-containing subtype;IPR019787,Zinc finger, PHD-finger;IPR003347,JmjC domain;IPR001810,F-box domain","KOG1947,Leucine rich repeat proteins, some proteins contain F-box;ENOG410XQXU,-;KOG1633,F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains","GO:0007283,biological_process,spermatogenesis;GO:0021555,biological_process,midbrain-hindbrain boundary morphogenesis;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0030900,biological_process,forebrain development;GO:0070544,biological_process,histone H3-K36 demethylation;GO:0031519,cellular_component,PcG protein complex;GO:0005634,cellular_component,nucleus;GO:0021993,biological_process,initiation of neural tube closure;GO:1902459,biological_process,positive regulation of stem cell population maintenance;GO:0032259,biological_process,methylation;GO:0021670,biological_process,lateral ventricle development;GO:0030307,biological_process,positive regulation of cell growth;GO:0035518,biological_process,histone H2A monoubiquitination;GO:0003677,molecular_function,DNA binding;GO:0030901,biological_process,midbrain development;GO:0030902,biological_process,hindbrain development;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0008270,molecular_function,zinc ion binding;GO:0048596,biological_process,embryonic camera-type eye morphogenesis;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0046872,molecular_function,metal ion binding;GO:2000178,biological_process,negative regulation of neural precursor cell proliferation;GO:0021592,biological_process,fourth ventricle development;GO:0008168,molecular_function,methyltransferase activity;GO:0021678,biological_process,third ventricle development","-"]
["MPHOSPH9",3.98685997,1.144786881,1.797178531,4.775508628,{"v":2.35e-08,"d":"2.35E-08"},{"v":1.59e-07,"d":"1.59E-07"},"ENSG00000051825","A0A0A0MTP3,M-phase phosphoprotein 9","-","-","IPR026636,M-phase phosphoprotein 9","ENOG410XSEU,-;ENOG410IKA1,-","-","-"]
["PDPK1",3.238290467,0.929669302,1.796965182,4.567287302,{"v":8.07e-08,"d":"8.07E-08"},{"v":4.83e-07,"d":"4.83E-07"},"ENSG00000140992","K7B926,3-phosphoinositide dependent protein kinase-1","-","PF14593,PH domain;PF00069,Protein kinase domain","IPR011993,PH-like domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR033931,PDK1-type, PH domain;IPR000719,Protein kinase domain","ENOG410XRT8,-;KOG0592,3-phosphoinositide-dependent protein kinase (PDK1)","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0016310,biological_process,phosphorylation","-"]
["ADSS",27.3344739,7.865352746,1.795912543,6.033956119,{"v":7.8e-12,"d":"7.80E-12"},1.15E-10,"ENSG00000035687","A0A024R5Q7,Adenylosuccinate synthetase isozyme 2","NP_001117.2,adenylosuccinate synthetase isozyme 2","PF00709,Adenylosuccinate synthetase","IPR018220,Adenylosuccinate synthase, GTP-binding site;IPR033128,Adenylosuccinate synthase,  active site;IPR001114,Adenylosuccinate synthetase;IPR027529,Adenylosuccinate synthetase isozyme 2, chordates;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG0104,Adenylosuccinate synthase;KOG1355,Adenylosuccinate synthase","GO:0060359,biological_process,response to ammonium ion;GO:0006164,biological_process,purine nucleotide biosynthetic process;GO:0005525,molecular_function,GTP binding;GO:0006167,biological_process,AMP biosynthetic process;GO:0046872,molecular_function,metal ion binding;GO:0014074,biological_process,response to purine-containing compound;GO:0005737,cellular_component,cytoplasm;GO:0005886,cellular_component,plasma membrane;GO:0016874,molecular_function,ligase activity;GO:0046040,biological_process,IMP metabolic process;GO:0005829,cellular_component,cytosol;GO:0006531,biological_process,aspartate metabolic process;GO:0000287,molecular_function,magnesium ion binding;GO:0000166,molecular_function,nucleotide binding;GO:0044208,biological_process,'de novo' AMP biosynthetic process;GO:0071257,biological_process,cellular response to electrical stimulus;GO:0004019,molecular_function,adenylosuccinate synthase activity","K01939,ko00230,Purine metabolism;K01939,ko00250,Alanine, aspartate and glutamate metabolism"]
["KBTBD11-OT1",4.299001876,1.235844022,1.794913662,4.520235328,{"v":1.46e-07,"d":"1.46E-07"},{"v":8.24e-07,"d":"8.24E-07"},"ENSG00000253696","A0A1B0GTJ5,Uncharacterized protein","-","PF03798,TLC domain","IPR006634,TRAM/LAG1/CLN8 homology domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["FAM102A",13.43012297,3.867502958,1.794500881,5.748228097,{"v":4.67e-11,"d":"4.67E-11"},{"v":5.73e-10,"d":"5.73E-10"},"ENSG00000167106","G3RFH0,Family with sequence similarity 102 member A","XP_004048714.1,-","PF10358,N-terminal C2 in EEIG1 and EHBP1 proteins","IPR019448,EEIG1/EHBP1 N-terminal domain","-","-","-"]
["PLEKHA7",3.522891024,1.013976257,1.79356782,4.693119631,{"v":4.59e-08,"d":"4.59E-08"},{"v":2.91E-7,"d":"2.91E-07"},"ENSG00000166689","E9PKC0,Pleckstrin homology domain-containing family A member 7","NP_001316559.1,pleckstrin homology domain-containing family A member 7 isoform 1","PF00169,PH domain","IPR001202,WW domain;IPR036020,WW domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","ENOG4111YSB,-;ENOG410INUD,-","GO:0005829,cellular_component,cytosol;GO:0030054,cellular_component,cell junction;GO:0005634,cellular_component,nucleus","-"]
["NUP160",6.894540132,1.986765292,1.792960957,5.287557323,8.38E-10,{"v":7.83e-09,"d":"7.83E-09"},"ENSG00000030066","H2R5F5,Nucleoporin 160kDa","XP_001170076.2,nuclear pore complex protein Nup160 isoform X1","PF11715,Nucleoporin Nup120/160","IPR021717,Nucleoporin Nup120/160","KOG4521,Nuclear pore complex, Nup160 component;ENOG410YYM5,-","GO:0006406,biological_process,mRNA export from nucleus;GO:0005643,cellular_component,nuclear pore;GO:0000776,cellular_component,kinetochore;GO:0031080,cellular_component,nuclear pore outer ring;GO:0017056,molecular_function,structural constituent of nuclear pore","-"]
["KAT7",4.931506975,1.422319831,1.791670909,5.259247292,{"v":1.07E-9,"d":"1.07E-09"},{"v":9.77e-09,"d":"9.77E-09"},"ENSG00000136504","F6SN79,Histone acetyltransferase","XP_001502556.1,-","PF01530,Zinc finger, C2HC type;PF01853,MOZ/SAS family","IPR036060,Zinc finger, C2HC-type superfamily;IPR016181,Acyl-CoA N-acyltransferase;IPR002515,Zinc finger, C2HC-type;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR002717,Histone acetyltransferase domain, MYST-type","COG5027,Histone acetyltransferase (MYST family);KOG2747,Histone acetyltransferase (MYST family)","GO:0043966,biological_process,histone H3 acetylation;GO:0043983,biological_process,histone H4-K12 acetylation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0072739,biological_process,response to anisomycin;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0090240,biological_process,positive regulation of histone H4 acetylation;GO:0005634,cellular_component,nucleus;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0008270,molecular_function,zinc ion binding;GO:0005829,cellular_component,cytosol;GO:1900182,biological_process,positive regulation of protein localization to nucleus;GO:0072708,biological_process,response to sorbitol;GO:0031098,biological_process,stress-activated protein kinase signaling cascade;GO:0006260,biological_process,DNA replication;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0043982,biological_process,histone H4-K8 acetylation;GO:0005654,cellular_component,nucleoplasm;GO:0043981,biological_process,histone H4-K5 acetylation;GO:0072716,biological_process,response to actinomycin D;GO:0004402,molecular_function,histone acetyltransferase activity;GO:0072710,biological_process,response to hydroxyurea;GO:0003688,molecular_function,DNA replication origin binding;GO:0000123,cellular_component,histone acetyltransferase complex;GO:0016573,biological_process,histone acetylation;GO:0072720,biological_process,response to dithiothreitol","-"]
["ZNF431",1.209816761,0.347788825,1.791338362,3.569288207,{"v":4.85E-5,"d":"4.85E-05"},0.000157724,"ENSG00000196705","A0A024R7Q8,Zinc finger protein 431, isoform CRA_b","NP_597730.2,zinc finger protein 431 isoform 2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF507",4.64820998,1.341090709,1.790927808,5.113691874,{"v":2.52E-9,"d":"2.52E-09"},{"v":2.11E-8,"d":"2.11E-08"},"ENSG00000168813","B9EGE7,ZNF507 protein","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["PCDH9",0.222542148,0.063533502,1.79064218,2.373435266,0.008412736,0.016327323,"ENSG00000184226","X5D7N0,Protocadherin 9 isoform A","XP_016876108.1,-;NP_982354.1,protocadherin-9 isoform 1 precursor","PF08374,Protocadherin;PF08266,Cadherin-like;PF00028,Cadherin domain","IPR013585,Protocadherin;IPR020894,Cadherin conserved site;IPR002126,Cadherin;IPR013164,Cadherin, N-terminal;IPR015919,Cadherin-like","ENOG410XQHI,-;KOG3594,FOG: Cadherin repeats","GO:0007155,biological_process,cell adhesion;GO:0030426,cellular_component,growth cone;GO:0044291,cellular_component,cell-cell contact zone;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0030900,biological_process,forebrain development;GO:0016021,cellular_component,integral component of membrane","-"]
["CTC-428G20.6",7.294856158,2.082606642,1.79064218,2.373435266,0.008412736,0.016327323,"ENSG00000271797","G3QFM5,Protein geranylgeranyltransferase type I subunit beta","XP_004042418.1,-","PF00432,Prenyltransferase and squalene oxidase repeat","IPR001330,PFTB repeat;IPR008930,Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid","-","GO:0003824,molecular_function,catalytic activity","-"]
["ORMDL1",5.459543512,1.572916993,1.789679548,3.888215474,{"v":7.64e-06,"d":"7.64E-06"},{"v":2.98e-05,"d":"2.98E-05"},"ENSG00000128699","A0A250YAG0,ORM1-like protein 1","XP_020027993.1,-;XP_020027992.1,-","-","IPR029884,ORM1-like protein 1;IPR007203,ORMDL family","-","GO:0090155,biological_process,negative regulation of sphingolipid biosynthetic process;GO:0016021,cellular_component,integral component of membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0006672,biological_process,ceramide metabolic process;GO:0016020,cellular_component,membrane","-"]
["TP53BP1",9.157688614,2.648345911,1.788866656,6.279737609,{"v":2.07e-12,"d":"2.07E-12"},{"v":3.46e-11,"d":"3.46E-11"},"ENSG00000067369","H2Q9A7,Uncharacterized protein","-","PF09038,Tumour suppressor p53-binding protein-1 Tudor","IPR015125,Tumour suppressor p53-binding protein-1 Tudor domain;IPR036420,BRCT domain superfamily;IPR001357,BRCT domain;IPR014722,Ribosomal protein L2, domain 2","KOG3548,DNA damage checkpoint protein RHP9/CRB2/53BP1;ENOG411075K,-","GO:0000077,biological_process,DNA damage checkpoint;GO:0005634,cellular_component,nucleus;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0042393,molecular_function,histone binding","-"]
["PHF2",22.17261188,6.41323676,1.788666537,6.332830043,{"v":1.72e-12,"d":"1.72E-12"},{"v":2.94e-11,"d":"2.94E-11"},"ENSG00000197724","H9FVT7,Lysine-specific demethylase PHF2","-","PF00628,PHD-finger;PF02373,JmjC domain, hydroxylase","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR019786,Zinc finger, PHD-type, conserved site;IPR003347,JmjC domain","ENOG410Y2FD,-;KOG1633,F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains","GO:0032259,biological_process,methylation;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0008168,molecular_function,methyltransferase activity","-"]
["PDK2",9.098089858,2.630394378,1.787839777,5.048983014,{"v":5.19e-09,"d":"5.19E-09"},{"v":4.06E-8,"d":"4.06E-08"},"ENSG00000005882","G1RCC5,Pyruvate dehydrogenase kinase 2","XP_003281289.2,pyruvate dehydrogenase kinase, isozyme 2 isoform X1","PF10436,Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase;PF02518,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase","IPR003594,Histidine kinase/HSP90-like ATPase;IPR018955,Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal;IPR036784,Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily;IPR005467,Histidine kinase domain;IPR036890,Histidine kinase/HSP90-like ATPase superfamily","COG0642,Signal transduction histidine kinase;KOG0787,Dehydrogenase kinase","GO:0005967,cellular_component,mitochondrial pyruvate dehydrogenase complex;GO:0031670,biological_process,cellular response to nutrient;GO:0006468,biological_process,protein phosphorylation;GO:0042593,biological_process,glucose homeostasis;GO:0010565,biological_process,regulation of cellular ketone metabolic process;GO:0010510,biological_process,regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0008286,biological_process,insulin receptor signaling pathway;GO:0042803,molecular_function,protein homodimerization activity;GO:0034614,biological_process,cellular response to reactive oxygen species;GO:0005739,cellular_component,mitochondrion;GO:0010906,biological_process,regulation of glucose metabolic process;GO:0006885,biological_process,regulation of pH;GO:0005829,cellular_component,cytosol;GO:0004740,molecular_function,pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0006111,biological_process,regulation of gluconeogenesis;GO:0005524,molecular_function,ATP binding;GO:0072332,biological_process,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0005654,cellular_component,nucleoplasm","-"]
["C11orf80",3.027380338,0.870288035,1.787779049,3.027404612,0.000591283,1.503955E-3,"ENSG00000173715","G3REV1,Chromosome 11 open reading frame 80","-","PF15091,omain of unknown function (DUF4554)","IPR028040,Type 2 DNA topoisomerase 6 subunit B-like","-","GO:0042138,biological_process,meiotic DNA double-strand break formation","-"]
["DSG2",29.61538484,8.575359952,1.787413353,6.897498725,{"v":1.15e-13,"d":"1.15E-13"},{"v":2.58e-12,"d":"2.58E-12"},"ENSG00000046604","K7DKT8,Desmoglein 2","-","PF00028,Cadherin domain","IPR002126,Cadherin;IPR015919,Cadherin-like;IPR027397,Catenin binding domain superfamily;IPR009123,Desmoglein;IPR009122,Desmosomal cadherin;IPR020894,Cadherin conserved site","ENOG410XQHI,-;KOG3594,FOG: Cadherin repeats","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["STX17",11.22174526,3.248983527,1.785949098,5.140079263,{"v":3.51e-09,"d":"3.51E-09"},{"v":2.86e-08,"d":"2.86E-08"},"ENSG00000136874","G1S5D7,Syntaxin 17","-","-","-","-","-","-"]
["IFNAR2",4.426001841,1.278270917,1.785844932,3.811786531,{"v":7.1e-06,"d":"7.10E-06"},{"v":2.8E-5,"d":"2.80E-05"},"ENSG00000159110","H2RAJ3,Interferon","-","PF01108,Tissue factor;PF09294,Interferon-alpha/beta receptor, fibronectin type III","IPR003961,Fibronectin type III;IPR015373,Interferon/interleukin receptor domain;IPR013783,Immunoglobulin-like fold;IPR036116,Fibronectin type III superfamily","ENOG410IHB9,-;ENOG410YTXY,-","GO:0060337,biological_process,type I interferon signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0004905,molecular_function,type I interferon receptor activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K05131,ko04650,Natural killer cell mediated cytotoxicity;K05131,ko04630,Jak-STAT signaling pathway;K05131,ko04151,PI3K-Akt signaling pathway;K05131,ko05164,Influenza A;K05131,ko04620,Toll-like receptor signaling pathway;K05131,ko04060,Cytokine-cytokine receptor interaction;K05131,ko05168,Herpes simplex infection;K05131,ko05162,Measles;K05131,ko04380,Osteoclast differentiation;K05131,ko05160,Hepatitis C"]
["DNMBP",16.69882832,4.840790762,1.785571753,6.525704444,{"v":6.85e-13,"d":"6.85E-13"},1.29E-11,"ENSG00000107554","K7DM01,Dynamin binding protein","-","PF07653,Variant SH3 domain;PF00621,RhoGEF domain;PF14604,Variant SH3 domain;PF00018,SH3 domain;PF03114,BAR domain","IPR035820,Dynamin-binding protein, first C-terminal SH3 domain;IPR035818,Dynamin-binding protein, second N-terminal SH3 domain;IPR004148,BAR domain;IPR035817,Dynamin-binding protein, first N-terminal SH3 domain;IPR001331,Guanine-nucleotide dissociation stimulator, CDC24, conserved site;IPR027267,AH/BAR domain superfamily;IPR000219,Dbl homology (DH) domain;IPR035469,Dynamin-binding protein;IPR035899,Dbl homology (DH) domain superfamily;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain;IPR035819,Dynamin-binding protein, third N-terminal SH3 domain","-","GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","-"]
["RHOBTB2",12.19780078,3.535578207,1.785088593,5.721198514,7.26E-11,{"v":8.53e-10,"d":"8.53E-10"},"ENSG00000008853","I2CWQ8,Rho related BTB domain containing 2","XP_015000454.1,rho-related BTB domain-containing protein 2 isoform X1","PF00071,Ras family;PF00651,BTB/POZ domain","IPR000210,BTB/POZ domain;IPR001806,Small GTPase superfamily;IPR011333,SKP1/BTB/POZ domain superfamily;IPR003578,Small GTPase superfamily, Rho type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1100,GTPase SAR1 and related small G proteins;KOG0393,Ras-related small GTPase, Rho type","GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular","K07868,ko04120,Ubiquitin mediated proteolysis"]
["ALDH3A2",35.85622451,10.40281961,1.784724352,7.232401497,2.64E-14,{"v":6.8e-13,"d":"6.80E-13"},"ENSG00000072210","G3QXF5,Aldehyde dehydrogenase","XP_004042166.1,fatty aldehyde dehydrogenase isoform X2","PF00171,Aldehyde dehydrogenase family","IPR016163,Aldehyde dehydrogenase, C-terminal;IPR016161,Aldehyde/histidinol dehydrogenase;IPR016160,Aldehyde dehydrogenase, cysteine active site;IPR015590,Aldehyde dehydrogenase domain;IPR016162,Aldehyde dehydrogenase, N-terminal;IPR012394,Aldehyde dehydrogenase NAD(P)-dependent;IPR029510,Aldehyde dehydrogenase, glutamic acid active site","-","GO:0008544,biological_process,epidermis development;GO:0007422,biological_process,peripheral nervous system development;GO:0004030,molecular_function,aldehyde dehydrogenase [NAD(P)+] activity;GO:0006081,biological_process,cellular aldehyde metabolic process;GO:0033306,biological_process,phytol metabolic process;GO:0005783,cellular_component,endoplasmic reticulum;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016491,molecular_function,oxidoreductase activity;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0046577,molecular_function,long-chain-alcohol oxidase activity;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0016620,molecular_function,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0055114,biological_process,oxidation-reduction process;GO:0007417,biological_process,central nervous system development;GO:0004029,molecular_function,aldehyde dehydrogenase (NAD) activity;GO:0016021,cellular_component,integral component of membrane;GO:0005739,cellular_component,mitochondrion","-"]
["QARS",34.04536917,9.882797197,1.78371014,6.706304253,{"v":2.93e-13,"d":"2.93E-13"},{"v":6.08e-12,"d":"6.08E-12"},"ENSG00000172053","M0RDR7,Glutamine--tRNA ligase-like","XP_003752277.1,-","PF03950,tRNA synthetases class I (E and Q), anti-codon binding domain;PF04557,lutaminyl-tRNA synthetase, non-specific RNA binding region part 2;PF04558,lutaminyl-tRNA synthetase, non-specific RNA binding region part 1;PF00749,tRNA synthetases class I (E and Q), catalytic domain","IPR011035,Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily;IPR020056,Ribosomal protein L25/Gln-tRNA synthetase, N-terminal;IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR007639,Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal;IPR020058,Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain;IPR001412,Aminoacyl-tRNA synthetase, class I, conserved site;IPR020059,Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain;IPR004514,Glutamine-tRNA synthetase;IPR007638,Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2;IPR000924,Glutamyl/glutaminyl-tRNA synthetase","COG0008,Glutamyl- and glutaminyl-tRNA synthetases;KOG1148,Glutaminyl-tRNA synthetase","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0004819,molecular_function,glutamine-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0006412,biological_process,translation;GO:0016874,molecular_function,ligase activity;GO:0043039,biological_process,tRNA aminoacylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0006425,biological_process,glutaminyl-tRNA aminoacylation","K01886,ko00970,Aminoacyl-tRNA biosynthesis"]
["TNKS2",10.4517946,3.033428028,1.782844791,5.409147232,{"v":4.6e-10,"d":"4.60E-10"},{"v":4.6e-09,"d":"4.60E-09"},"ENSG00000107854","G3R2V0,Poly [ADP-ribose] polymerase","XP_004049837.1,-","PF12796,Ankyrin repeats (3 copies);PF13857,Ankyrin repeats (many copies);PF00644,Poly(ADP-ribose) polymerase catalytic domain;PF13637,Ankyrin repeats (many copies);PF07647,SAM domain (Sterile alpha motif)","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR002110,Ankyrin repeat;IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR012317,Poly(ADP-ribose) polymerase, catalytic domain;IPR001660,Sterile alpha motif domain","-","GO:0000209,biological_process,protein polyubiquitination;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0070213,biological_process,protein auto-ADP-ribosylation;GO:0019899,molecular_function,enzyme binding;GO:0005737,cellular_component,cytoplasm;GO:1904357,biological_process,negative regulation of telomere maintenance via telomere lengthening;GO:0070198,biological_process,protein localization to chromosome, telomeric region;GO:0016740,molecular_function,transferase activity;GO:0000242,cellular_component,pericentriolar material;GO:0035264,biological_process,multicellular organism growth;GO:0005634,cellular_component,nucleus;GO:0003950,molecular_function,NAD+ ADP-ribosyltransferase activity;GO:0006471,biological_process,protein ADP-ribosylation;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway;GO:0005635,cellular_component,nuclear envelope;GO:1904355,biological_process,positive regulation of telomere capping;GO:0040014,biological_process,regulation of multicellular organism growth","-"]
["CENPP",4.267202937,1.237854551,1.782546422,4.802591554,{"v":3.31e-08,"d":"3.31E-08"},{"v":2.17E-7,"d":"2.17E-07"},"ENSG00000188312","H2R6L4,Centromere protein P","-","PF13096,CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P","IPR027801,Centromere protein P","ENOG410YMCC,-;ENOG410IJM3,-","GO:0034080,biological_process,CENP-A containing nucleosome assembly;GO:0000775,cellular_component,chromosome, centromeric region","-"]
["C1orf21",14.99953338,4.360483364,1.781621724,6.744381701,{"v":2.83e-13,"d":"2.83E-13"},{"v":5.89e-12,"d":"5.89E-12"},"ENSG00000116667","F7FJY2,Uncharacterized protein C1orf21","XP_002760319.1,-","PF15389,omain of unknown function (DUF4612)","IPR027967,Protein of unknown function DUF4612","ENOG4111YV6,-;ENOG410IW2D,-","-","-"]
["BRD2",43.75713731,12.72782906,1.781154995,7.702142454,5.51E-15,{"v":1.69e-13,"d":"1.69E-13"},"ENSG00000204256","A0A0G2JK44,Bromodomain-containing protein 2","-","PF17035,Bromodomain extra-terminal - transcription regulation;PF00439,Bromodomain","IPR018359,Bromodomain, conserved site;IPR027353,NET domain;IPR001487,Bromodomain;IPR038336,NET domain superfamily;IPR036427,Bromodomain-like superfamily","-","-","-"]
["RP11-60I3.4",43.81705062,12.67745472,1.780985249,3.369737671,{"v":8.55e-05,"d":"8.55E-05"},0.000261856,"ENSG00000254571","A0A1V4J9H5,Syntaxin-17","-","-","IPR000727,Target SNARE coiled-coil homology domain;IPR010989,SNARE;IPR028676,Syntaxin-17","-","GO:0000149,molecular_function,SNARE binding;GO:0005737,cellular_component,cytoplasm;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0097352,biological_process,autophagosome maturation;GO:0097111,biological_process,endoplasmic reticulum-Golgi intermediate compartment organization;GO:0016021,cellular_component,integral component of membrane","-"]
["MARVELD1",22.34753661,6.49702599,1.780661695,5.635749013,{"v":1.23e-10,"d":"1.23E-10"},{"v":1.37E-9,"d":"1.37E-09"},"ENSG00000155254","H2Q2D6,MARVEL domain containing 1","XP_529337.2,-","PF01284,Membrane-associating domain","IPR008253,Marvel domain","KOG4788,Members of chemokine-like factor super family and related proteins;ENOG4111IAF,-","GO:0045121,cellular_component,membrane raft;GO:0019911,molecular_function,structural constituent of myelin sheath;GO:0001766,biological_process,membrane raft polarization;GO:0008104,biological_process,protein localization;GO:0042552,biological_process,myelination;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["TTN",0.085822235,0.024786268,1.779923931,2.883990998,0.000864433,0.002114503,"ENSG00000283186","A0A0A0MTS7,Titin","NP_001254479.2,titin isoform IC","PF00069,Protein kinase domain;PF00041,ibronectin type III domain;PF02818,PPAK motif;PF09042,Titin Z;PF07679,Immunoglobulin I-set domain","IPR007110,Immunoglobulin-like domain;IPR003961,Fibronectin type III;IPR013106,Immunoglobulin V-set domain;IPR036116,Fibronectin type III superfamily;IPR004168,PPAK motif;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR008266,Tyrosine-protein kinase, active site;IPR015129,Titin, Z repeat;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","ENOG410XQFD,-;KOG0613,Projectin/twitchin and related proteins","GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["RP5-1165K10.2",4.918490485,1.420506265,1.779923931,2.883990998,0.000864433,0.002114503,"ENSG00000273432","H2PLT9,Uncharacterized protein","-","PF00779,BTK motif;PF00616,TPase-activator protein for Ras-like GTPase;PF13656,RNA polymerase Rpb3/Rpb11 dimerisation domain;PF00168,C2 domain;PF00169,PH domain","IPR008193,DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site;IPR036603,RNA polymerase, RBP11-like subunit;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR009025,DNA-directed RNA polymerase, RBP11-like dimerisation domain;IPR001936,Ras GTPase-activating domain;IPR000008,C2 domain;IPR037685,RNA polymerase RBP11;IPR035892,C2 domain superfamily;IPR008936,Rho GTPase activation protein;IPR023152,Ras GTPase-activating protein, conserved site;IPR037777,RASA4, PH domain;IPR001562,Zinc finger, Btk motif","ENOG410Y128,-;KOG2059,Ras GTPase-activating protein;KOG4392,RNA polymerase, subunit L","GO:0046983,molecular_function,protein dimerization activity;GO:0071277,biological_process,cellular response to calcium ion;GO:0046580,biological_process,negative regulation of Ras protein signal transduction;GO:0035556,biological_process,intracellular signal transduction;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0005665,cellular_component,DNA-directed RNA polymerase II, core complex;GO:0043087,biological_process,regulation of GTPase activity;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0005096,molecular_function,GTPase activator activity;GO:0001055,molecular_function,RNA polymerase II activity;GO:0003677,molecular_function,DNA binding;GO:0005543,molecular_function,phospholipid binding;GO:0007165,biological_process,signal transduction","-"]
["ARF1",88.15192227,25.66580475,1.779726639,7.552643067,1.07E-14,{"v":3.06e-13,"d":"3.06E-13"},"ENSG00000143761","A0A250YB79,ADP-ribosylation factor 1","XP_020040914.1,-;XP_020040912.1,-;XP_020040913.1,-","-","IPR006689,Small GTPase superfamily, ARF/SAR type;IPR005225,Small GTP-binding protein domain;IPR024156,Small GTPase superfamily, ARF type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular","K07937,ko04144,Endocytosis;K07937,ko05110,Vibrio cholerae infection;K07937,ko04072,Phospholipase D signaling pathway;K07937,ko05134,Legionellosis"]
["CLIP2",7.239044757,2.105288027,1.779498259,5.135156109,{"v":2.73e-09,"d":"2.73E-09"},{"v":2.27e-08,"d":"2.27E-08"},"ENSG00000106665","A0A140VJG6,Cytoplasmic linker 2, isoform CRA_b","NP_003379.3,CAP-Gly domain-containing linker protein 2 isoform 1","PF01302,CAP-Gly domain","IPR000938,CAP Gly-rich domain;IPR036859,CAP Gly-rich domain superfamily;IPR028394,CAP-Gly domain-containing linker protein 2","-","-","-"]
["RMND5A",20.17224632,5.875211684,1.77877907,6.485822362,{"v":9.38e-13,"d":"9.38E-13"},{"v":1.71e-11,"d":"1.71E-11"},"ENSG00000153561","D3ZWU9,Required for meiotic nuclear division 5 homolog A","XP_232051.4,-","PF10607,CTLH/CRA C-terminal to LisH motif domain","IPR024964,CTLH/CRA C-terminal to LisH motif domain;IPR013144,CRA domain;IPR037680,Protein RMD5 homolog A, degenerated RING finger;IPR006594,LIS1 homology motif;IPR006595,CTLH, C-terminal LisH motif","KOG2817,Predicted E3 ubiquitin ligase;COG5109,Uncharacterized conserved protein, contains RING Zn-finger","GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0034657,cellular_component,GID complex;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0005634,cellular_component,nucleus","-"]
["LRRC45",6.255882918,1.8173236,1.778040009,3.949424576,{"v":6.05e-06,"d":"6.05E-06"},{"v":2.42e-05,"d":"2.42E-05"},"ENSG00000169683","H2QE40,Leucine rich repeat containing 45","XP_511754.2,leucine-rich repeat-containing protein 45 isoform X1","PF13516,Leucine Rich repeat","IPR001611,Leucine-rich repeat;IPR032675,Leucine-rich repeat domain superfamily","KOG4308,LRR-containing protein;ENOG410ZBX3,-","GO:0005829,cellular_component,cytosol;GO:0005813,cellular_component,centrosome;GO:0005886,cellular_component,plasma membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["BTBD3",7.58743881,2.209676412,1.777224465,4.975716523,{"v":1.11E-8,"d":"1.11E-08"},{"v":8.09e-08,"d":"8.09E-08"},"ENSG00000132640","H2QJZ1,BTB","XP_016792944.1,BTB/POZ domain-containing protein 3 isoform X2","PF08005,PHR domain;PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch","IPR011705,BTB/Kelch-associated;IPR000210,BTB/POZ domain;IPR038648,PHR domain superfamily;IPR011333,SKP1/BTB/POZ domain superfamily;IPR012983,PHR","KOG2075,Topoisomerase TOP1-interacting protein BTBD1;ENOG410XQ3X,-","GO:0019005,cellular_component,SCF ubiquitin ligase complex;GO:0021987,biological_process,cerebral cortex development;GO:0048813,biological_process,dendrite morphogenesis;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0005829,cellular_component,cytosol;GO:0030162,biological_process,regulation of proteolysis;GO:0005634,cellular_component,nucleus","-"]
["PGBD2",1.560954119,0.448731094,1.777195869,2.138022865,0.009625718,0.018410587,"ENSG00000185220","H2N335,PiggyBac transposable element derived 2","XP_009239806.1,piggyBac transposable element-derived protein 2 isoform X1","PF13843,Transposase IS4","IPR029526,PiggyBac transposable element-derived protein","ENOG410ZDPG,-;ENOG410IHMN,-","-","-"]
["RP11-599B13.6",12.38922497,3.561559186,1.777195869,2.138022865,0.009625718,0.018410587,"ENSG00000263620","L7N2F9,Uncharacterized protein","-","PF00957,Synaptobrevin","IPR016444,Synaptobrevin/Vesicle-associated membrane protein;IPR028717,Vesicle-associated membrane protein 2;IPR001388,Synaptobrevin","KOG0860,Synaptobrevin/VAMP-like protein;COG5143,Synaptobrevin/VAMP-like protein","GO:0006906,biological_process,vesicle fusion;GO:0031201,cellular_component,SNARE complex;GO:0005484,molecular_function,SNAP receptor activity;GO:0006887,biological_process,exocytosis;GO:0019905,molecular_function,syntaxin binding;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0016021,cellular_component,integral component of membrane","-"]
["ADRA1B",3.279081408,0.942645124,1.777195869,2.138022865,0.009625718,0.018410587,"ENSG00000170214","G3QHV1,Adrenoceptor alpha 1B","XP_004042970.2,alpha-1B adrenergic receptor","PF00001,7 transmembrane receptor (rhodopsin family)","IPR001115,Alpha 1B adrenoceptor;IPR017452,GPCR, rhodopsin-like, 7TM;IPR002233,Adrenoceptor family;IPR000276,G protein-coupled receptor, rhodopsin-like","-","GO:0071875,biological_process,adrenergic receptor signaling pathway;GO:0004937,molecular_function,alpha1-adrenergic receptor activity;GO:0006937,biological_process,regulation of muscle contraction;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0055117,biological_process,regulation of cardiac muscle contraction;GO:0004871,molecular_function,signal transducer activity;GO:0004935,molecular_function,adrenergic receptor activity;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0019229,biological_process,regulation of vasoconstriction;GO:0016021,cellular_component,integral component of membrane","-"]
["FAM20C",1.231160831,0.353924654,1.777195869,2.138022865,0.009625718,0.018410587,"ENSG00000177706","K7DIZ8,Family with sequence similarity 20, member C","-","PF06702,olgi casein kinase, C-terminal, Fam20","IPR024869,FAM20;IPR009581,FAM20, C-terminal","-","-","-"]
["USP36",10.82519991,3.157774403,1.776208469,6.034864299,{"v":1.19e-11,"d":"1.19E-11"},{"v":1.68e-10,"d":"1.68E-10"},"ENSG00000055483","A0A024R8V6,Ubiquitin specific peptidase 36, isoform CRA_b","XP_005257599.1,-;XP_005257600.1,-;NP_001308220.1,ubiquitin carboxyl-terminal hydrolase 36;XP_016880389.1,-","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","KOG1865,Ubiquitin carboxyl-terminal hydrolase;ENOG410XQ92,-","GO:0050821,biological_process,protein stabilization;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0005730,cellular_component,nucleolus;GO:0007000,biological_process,nucleolus organization;GO:2000232,biological_process,regulation of rRNA processing;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016607,cellular_component,nuclear speck;GO:0016579,biological_process,protein deubiquitination","-"]
["COASY",14.48789577,4.22581824,1.775483766,5.274198802,{"v":1.16e-09,"d":"1.16E-09"},{"v":1.06e-08,"d":"1.06E-08"},"ENSG00000068120","H2QD24,Uncharacterized protein","XP_009430422.1,bifunctional coenzyme A synthase isoform X1","PF01467,Cytidylyltransferase-like;PF01121,ephospho-CoA kinase","IPR004821,Cytidyltransferase-like domain;IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR001977,Dephospho-CoA kinase;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG3351,Predicted nucleotidyltransferase;COG1019,Predicted nucleotidyltransferase;KOG3220,Similar to bacterial dephospho-CoA kinase;COG0237,Dephospho-CoA kinase","GO:0004140,molecular_function,dephospho-CoA kinase activity;GO:0004595,molecular_function,pantetheine-phosphate adenylyltransferase activity;GO:0003824,molecular_function,catalytic activity;GO:0005524,molecular_function,ATP binding;GO:0005759,cellular_component,mitochondrial matrix;GO:0009058,biological_process,biosynthetic process;GO:0005829,cellular_component,cytosol;GO:0015937,biological_process,coenzyme A biosynthetic process;GO:0016310,biological_process,phosphorylation;GO:0005654,cellular_component,nucleoplasm","-"]
["TNKS",4.670194596,1.362762108,1.775131877,5.451890812,{"v":5.06e-10,"d":"5.06E-10"},{"v":4.99e-09,"d":"4.99E-09"},"ENSG00000173273","A0A091E1F5,Poly [ADP-ribose] polymerase","-","PF12796,Ankyrin repeats (3 copies);PF13857,Ankyrin repeats (many copies);PF00644,Poly(ADP-ribose) polymerase catalytic domain;PF13637,Ankyrin repeats (many copies);PF07647,SAM domain (Sterile alpha motif)","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR002110,Ankyrin repeat;IPR001660,Sterile alpha motif domain;IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR012317,Poly(ADP-ribose) polymerase, catalytic domain;IPR028731,Tankyrase-1","-","GO:0051225,biological_process,spindle assembly;GO:0016055,biological_process,Wnt signaling pathway;GO:0003950,molecular_function,NAD+ ADP-ribosyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0032212,biological_process,positive regulation of telomere maintenance via telomerase","-"]
["RP13-279N23.2",3.098015171,0.899968263,1.774487942,3.258350449,0.000218654,0.000613202,"ENSG00000255275","G7MHB7,Uncharacterized protein","-","PF00038,Intermediate filament protein","IPR001664,Intermediate filament protein","COG1012,NAD-dependent aldehyde dehydrogenases;KOG2455,Delta-1-pyrroline-5-carboxylate dehydrogenase","GO:0005882,cellular_component,intermediate filament;GO:0005198,molecular_function,structural molecule activity","-"]
["NFX1",5.183123361,1.512927618,1.773233472,4.636142896,{"v":9.86e-08,"d":"9.86E-08"},{"v":5.78e-07,"d":"5.78E-07"},"ENSG00000086102","H2R0P2,Nuclear transcription factor, X-box binding 1","XP_001159552.2,-","PF01424,R3H domain;PF01422,NF-X1 type zinc finger","IPR001374,R3H domain;IPR000967,Zinc finger, NF-X1-type;IPR019787,Zinc finger, PHD-finger;IPR036867,R3H domain superfamily;IPR001841,Zinc finger, RING-type;IPR034076,Transcriptional repressor NF-X1, R3H domain;IPR034078,Transcription factor NFX1 family;IPR019786,Zinc finger, PHD-type, conserved site","KOG1952,Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains;ENOG410XR02,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005730,cellular_component,nucleolus;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0005886,cellular_component,plasma membrane;GO:0045347,biological_process,negative regulation of MHC class II biosynthetic process;GO:0005829,cellular_component,cytosol;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["CASC4",24.02626398,7.026749182,1.772963693,6.766778488,{"v":2.77e-13,"d":"2.77E-13"},{"v":5.77e-12,"d":"5.77E-12"},"ENSG00000166734","H2Q9B8,Cancer susceptibility candidate 4","XP_009427239.1,protein CASC4 isoform X1","-","IPR026141,Cancer susceptibility candidate 4;IPR026139,GOLM1/CASC4 family","ENOG410IHYU,-;ENOG4111SUN,-","GO:0005794,cellular_component,Golgi apparatus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SERTAD2",14.64728662,4.282499601,1.772801668,5.915941098,2.82E-11,{"v":3.68e-10,"d":"3.68E-10"},"ENSG00000179833","H2R8S8,SERTA domain containing 2","XP_009440837.1,-;XP_016804124.1,-;XP_016804125.1,-","PF06031,SERTA motif","IPR009263,SERTA domain","ENOG4110A16,-;ENOG410IEG3,-","GO:0005737,cellular_component,cytoplasm;GO:0003713,molecular_function,transcription coactivator activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0030308,biological_process,negative regulation of cell growth;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["ULK1",5.306023225,1.550457942,1.771962553,4.756334637,{"v":3.51e-08,"d":"3.51E-08"},{"v":2.3e-07,"d":"2.30E-07"},"ENSG00000177169","K7C6S3,Unc-51-like kinase 1","-","PF12063,omain of unknown function (DUF3543);PF00069,Protein kinase domain","IPR022708,Serine/threonine-protein kinase, C-terminal;IPR016237,Serine/threonine-protein kinase, Ulk1/Ulk2;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0016301,molecular_function,kinase activity;GO:0007409,biological_process,axonogenesis;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0007165,biological_process,signal transduction;GO:0004672,molecular_function,protein kinase activity","-"]
["ATF6B",39.44693124,11.54879356,1.771340487,6.559696588,{"v":9.07e-13,"d":"9.07E-13"},1.66E-11,"ENSG00000213676","Q6AZW6,Activating transcription factor 6 beta","NP_004372.3,cyclic AMP-dependent transcription factor ATF-6 beta isoform a","PF00170,bZIP transcription factor","IPR029809,cAMP-dependent transcription factor ATF-6 beta;IPR004827,Basic-leucine zipper domain","ENOG410ZAAP,-;KOG4343,bZIP transcription factor ATF6","GO:0012505,cellular_component,endomembrane system;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0035497,molecular_function,cAMP response element binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0005634,cellular_component,nucleus","K09049,ko04668,TNF signaling pathway;K09049,ko04022,cGMP-PKG signaling pathway;K09049,ko05034,Alcoholism;K09049,ko04911,Insulin secretion;K09049,ko04141,Protein processing in endoplasmic reticulum;K09049,ko05030,Cocaine addiction;K09049,ko04915,Estrogen signaling pathway;K09049,ko04151,PI3K-Akt signaling pathway;K09049,ko04925,Aldosterone synthesis and secretion;K09049,ko04211,Longevity regulating pathway;K09049,ko04728,Dopaminergic synapse;K09049,ko05203,Viral carcinogenesis;K09049,ko04918,Thyroid hormone synthesis;K09049,ko05031,Amphetamine addiction;K09049,ko04261,Adrenergic signaling in cardiomyocytes;K09049,ko05161,Hepatitis B"]
["ZNF213-AS1",3.276903851,0.955287012,1.771201305,3.554301033,{"v":4.85E-5,"d":"4.85E-05"},0.000157724,"ENSG00000263072","G7MPF7,Uncharacterized protein","-","-","-","-","-","-"]
["VPS13B",4.41792924,1.293717838,1.770225157,5.606495852,{"v":1.97e-10,"d":"1.97E-10"},{"v":2.11E-9,"d":"2.11E-09"},"ENSG00000132549","H2QWI0,Vacuolar protein sorting 13 homolog B","-","PF06650,SHR-binding domain of vacuolar-sorting associated protein 13;PF12624,N-terminal region of Chorein or VPS13;PF16909,Vacuolar-sorting-associated 13 protein C-terminal","IPR026854,Vacuolar protein sorting-associated protein 13, N-terminal domain","COG5043,Vacuolar protein sorting-associated protein;KOG1809,Vacuolar protein sorting-associated protein","-","-"]
["ENPP5",2.116202045,0.61475318,1.770070202,2.724353013,0.00179023,0.004095262,"ENSG00000112796","G3RK49,Ectonucleotide pyrophosphatase/phosphodiesterase 5","XP_004044182.1,-;XP_004044181.1,ectonucleotide pyrophosphatase/phosphodiesterase family member 5","PF01663,Type I phosphodiesterase / nucleotide pyrophosphatase","IPR002591,Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase;IPR017850,Alkaline-phosphatase-like, core domain superfamily;IPR017849,Alkaline phosphatase-like, alpha/beta/alpha","-","GO:0003824,molecular_function,catalytic activity;GO:0008152,biological_process,metabolic process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SAMD9L",3.927161478,1.148084951,1.769979272,4.249380751,{"v":1.04E-6,"d":"1.04E-06"},{"v":4.88e-06,"d":"4.88E-06"},"ENSG00000177409","G3QQ52,Sterile alpha motif domain containing 9 like","-","-","-","-","-","-"]
["KIRREL",4.977251521,1.456836964,1.769453136,4.715171902,{"v":6.03e-08,"d":"6.03E-08"},{"v":3.72E-7,"d":"3.72E-07"},"ENSG00000183853","H2N599,Kirre like nephrin family adhesion molecule 1","XP_009240939.1,kin of IRRE-like protein 1 isoform X2","PF13927,Immunoglobulin domain;PF08205,CD80-like C2-set immunoglobulin domain;PF07679,Immunoglobulin I-set domain","IPR007110,Immunoglobulin-like domain;IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","ENOG410XPX0,-;KOG3510,FOG: Immunoglobulin C-2 Type/fibronectin type III domains","GO:0005911,cellular_component,cell-cell junction;GO:0030838,biological_process,positive regulation of actin filament polymerization;GO:0098609,biological_process,cell-cell adhesion;GO:0043198,cellular_component,dendritic shaft;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0005886,cellular_component,plasma membrane;GO:0017022,molecular_function,myosin binding;GO:0016020,cellular_component,membrane;GO:0007588,biological_process,excretion;GO:0016021,cellular_component,integral component of membrane","-"]
["AMOTL2",57.30154575,16.81027367,1.768882089,7.799420606,6.26E-15,1.89E-13,"ENSG00000114019","G1QUA3,Angiomotin like 2","XP_012364028.1,angiomotin-like protein 2 isoform X3","PF12240,Angiomotin C terminal","IPR009114,Angiomotin;IPR024646,Angiomotin, C-terminal","ENOG410IEF3,-;ENOG410ZEXZ,-","-","-"]
["PEX10",14.16362967,4.150922503,1.768458262,5.156306726,{"v":3.79e-09,"d":"3.79E-09"},{"v":3.06e-08,"d":"3.06E-08"},"ENSG00000157911","A0A024R0A4,Peroxisome biogenesis factor 10, isoform CRA_b","NP_722540.1,peroxisome biogenesis factor 10 isoform 1","PF04757,Pex2 / Pex12 amino terminal region;PF13920,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR006845,Pex, N-terminal;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR025654,Peroxisome biogenesis factor 10","COG5574,RING-finger-containing E3 ubiquitin ligase;KOG0317,Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein","GO:0007031,biological_process,peroxisome organization;GO:0005779,cellular_component,integral component of peroxisomal membrane;GO:0005778,cellular_component,peroxisomal membrane;GO:0016558,biological_process,protein import into peroxisome matrix;GO:0008270,molecular_function,zinc ion binding;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["NFIA",4.21539809,1.235669725,1.767767158,4.934794826,{"v":1.39E-8,"d":"1.39E-08"},{"v":9.9E-8,"d":"9.90E-08"},"ENSG00000162599","F7I543,Nuclear factor 1","XP_002750935.1,-","PF00859,CTF/NF-I family transcription modulation region;PF03165,MH1 domain;PF10524,Nuclear factor I protein pre-N-terminus","IPR020604,CTF transcription factor/nuclear factor 1, DNA-binding domain;IPR000647,CTF transcription factor/nuclear factor 1;IPR003619,MAD homology 1, Dwarfin-type;IPR019548,CTF transcription factor/nuclear factor 1, N-terminal;IPR019739,CTF transcription factor/nuclear factor 1, conserved site","KOG3663,Nuclear factor I;ENOG410Y16G,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030054,cellular_component,cell junction;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0006260,biological_process,DNA replication;GO:0072189,biological_process,ureter development;GO:0060074,biological_process,synapse maturation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","-"]
["ENAH",75.46509935,22.1723868,1.766940383,9.522516784,{"v":1.92e-16,"d":"1.92E-16"},{"v":7.87e-15,"d":"7.87E-15"},"ENSG00000154380","A0A0U1RRM6,Protein enabled homolog","-","PF00568,WH1 domain;PF08776,VASP tetramerisation domain","IPR038023,VASP tetramerisation domain superfamily;IPR014885,VASP tetramerisation;IPR011993,PH-like domain superfamily;IPR000697,WH1/EVH1 domain","-","GO:0005829,cellular_component,cytosol;GO:0030054,cellular_component,cell junction;GO:0005886,cellular_component,plasma membrane;GO:0005925,cellular_component,focal adhesion","-"]
["RP11-613D13.10",42.72639292,12.47161902,1.76678265,3.137457371,0.000418716,0.001103752,"-","-","-","-","-","-","-","-"]
["QSOX1",5.636203642,1.653977223,1.7665094,5.125258093,{"v":3.86e-09,"d":"3.86E-09"},{"v":3.11e-08,"d":"3.11E-08"},"ENSG00000116260","H2Q0P8,Sulfhydryl oxidase","XP_009437523.1,sulfhydryl oxidase 1 isoform X1","PF00085,Thioredoxin;PF04777,rv1 / Alr family","IPR017905,ERV/ALR sulfhydryl oxidase domain;IPR013766,Thioredoxin domain;IPR036249,Thioredoxin-like superfamily;IPR036774,ERV/ALR sulfhydryl oxidase domain superfamily","KOG1731,FAD-dependent sulfhydryl oxidase/quiescin and related proteins;ENOG410XVJT,-","GO:0005794,cellular_component,Golgi apparatus;GO:0003756,molecular_function,protein disulfide isomerase activity;GO:0070062,cellular_component,extracellular exosome;GO:0045171,cellular_component,intercellular bridge;GO:0045454,biological_process,cell redox homeostasis;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016491,molecular_function,oxidoreductase activity;GO:0030173,cellular_component,integral component of Golgi membrane;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0016971,molecular_function,flavin-linked sulfhydryl oxidase activity;GO:0016242,biological_process,negative regulation of macroautophagy;GO:0016972,molecular_function,thiol oxidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space","-"]
["COG7",6.178447252,1.810712107,1.766235685,4.190378323,{"v":1.6e-06,"d":"1.60E-06"},{"v":7.29e-06,"d":"7.29E-06"},"ENSG00000168434","A0A0S2Z652,Component of oligomeric golgi complex 7 isoform 1","NP_705831.1,conserved oligomeric Golgi complex subunit 7","PF10191,olgi complex component 7 (COG7)","IPR019335,Conserved oligomeric Golgi complex subunit 7","-","GO:0005794,cellular_component,Golgi apparatus;GO:0005730,cellular_component,nucleolus;GO:0017119,cellular_component,Golgi transport complex;GO:0006886,biological_process,intracellular protein transport","-"]
["MT-TS1",3455.217186,1016.231554,1.765047492,7.278794683,4.45E-14,{"v":1.1E-12,"d":"1.10E-12"},"-","-","-","-","-","-","-","-"]
["FBXL17",1.928907026,0.564589321,1.764890161,3.456955147,1.16767E-4,0.00034773,"ENSG00000145743","F6XQQ2,F-box and leucine rich repeat protein 17","-","PF12937,-box-like;PF13516,Leucine Rich repeat","IPR001611,Leucine-rich repeat;IPR006553,Leucine-rich repeat, cysteine-containing subtype;IPR036047,F-box-like domain superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR001810,F-box domain","KOG1947,Leucine rich repeat proteins, some proteins contain F-box;ENOG410XQ54,-","-","-"]
["FCHO2",8.371371206,2.460016072,1.764473188,5.093523648,{"v":5.07e-09,"d":"5.07E-09"},{"v":3.97e-08,"d":"3.97E-08"},"ENSG00000157107","K7CMX2,FCH domain only 2","XP_526898.2,F-BAR domain only protein 2 isoform X1","PF00611,es/CIP4, and EFC/F-BAR homology domain;PF10291,Muniscin C-terminal mu homology domain","IPR018808,Muniscin C-terminal;IPR028565,Mu homology domain;IPR031160,F-BAR domain;IPR001060,FCH domain;IPR027267,AH/BAR domain superfamily;IPR030122,F-BAR domain only protein 2","ENOG410Y7RY,-;KOG2398,Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP)","GO:0005546,molecular_function,phosphatidylinositol-4,5-bisphosphate binding;GO:0072583,biological_process,clathrin-dependent endocytosis;GO:0048488,biological_process,synaptic vesicle endocytosis;GO:0010324,biological_process,membrane invagination;GO:0005905,cellular_component,clathrin-coated pit;GO:0072659,biological_process,protein localization to plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0001786,molecular_function,phosphatidylserine binding;GO:0048268,biological_process,clathrin coat assembly;GO:0042802,molecular_function,identical protein binding;GO:0045202,cellular_component,synapse;GO:0030136,cellular_component,clathrin-coated vesicle","-"]
["TMEM63B",16.36730945,4.813135351,1.764124077,5.580249907,{"v":2.77e-10,"d":"2.77E-10"},{"v":2.88E-9,"d":"2.88E-09"},"ENSG00000137216","K7CJ87,Transmembrane protein 63B","XP_009449629.2,-;XP_016811091.1,-;XP_016811092.1,-;XP_016811093.1,-","PF14703,Cytosolic domain of 10TM putative phosphate transporter;PF02714,Calcium-dependent channel, 7TM region, putative phosphate;PF13967,Late exocytosis, associated with Golgi transport","IPR003864,Calcium-dependent channel, 7TM region, putative phosphate;IPR027815,10TM putative phosphate transporter, cytosolic domain;IPR032880,Calcium permeable stress-gated cation channel 1, N-terminal transmembrane domain","COG5594,Uncharacterized integral membrane protein;KOG1134,Uncharacterized conserved protein","GO:0015629,cellular_component,actin cytoskeleton;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["LAMA3",6.919042837,2.035477695,1.763932665,5.943346098,{"v":2.61e-11,"d":"2.61E-11"},3.45E-10,"ENSG00000053747","B0YJ32,Laminin alpha-3 chain variant 1","-","PF00053,Laminin EGF domain;PF06009,Laminin Domain II;PF00055,Laminin N-terminal (Domain VI);PF02210,Laminin G domain;PF00052,Laminin B (Domain IV);PF06008,Laminin Domain I","IPR010307,Laminin domain II;IPR000034,Laminin IV;IPR008211,Laminin, N-terminal;IPR009254,Laminin alpha, domain I;IPR001791,Laminin G domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR002049,Laminin EGF domain;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR038684,Laminin, N-terminal domain superfamily","KOG1836,Extracellular matrix glycoprotein Laminin subunits alpha and gamma;ENOG410XRDC,-","GO:0005102,molecular_function,signaling receptor binding;GO:0030334,biological_process,regulation of cell migration;GO:0007155,biological_process,cell adhesion;GO:0030155,biological_process,regulation of cell adhesion;GO:0045995,biological_process,regulation of embryonic development","-"]
["DEPDC5",2.317814986,0.679633793,1.763660177,3.7176746449999998,{"v":2.12E-5,"d":"2.12E-05"},{"v":7.51e-05,"d":"7.51E-05"},"ENSG00000100150","H2RCS7,Uncharacterized protein","XP_016794520.1,-;XP_016794521.1,-;XP_016802755.1,-;XP_016802754.1,DEP domain-containing protein 5 isoform X1","PF00610,omain found in Dishevelled, Egl-10, and Pleckstrin (DEP);PF12257,Vacuolar membrane-associated protein Iml1","IPR027244,Vacuolar membrane-associated protein Iml1;IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000591,DEP domain","ENOG410XQVG,-;KOG3572,Uncharacterized conserved protein, contains DEP domain","GO:0010506,biological_process,regulation of autophagy;GO:0035556,biological_process,intracellular signal transduction;GO:0032007,biological_process,negative regulation of TOR signaling;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005765,cellular_component,lysosomal membrane;GO:0005096,molecular_function,GTPase activator activity;GO:1990130,cellular_component,GATOR1 complex;GO:0034198,biological_process,cellular response to amino acid starvation","-"]
["RBM41",7.667537882,2.25567361,1.762662325,4.964642145,{"v":1.03E-8,"d":"1.03E-08"},{"v":7.56e-08,"d":"7.56E-08"},"ENSG00000089682","G3QUP0,RNA binding motif protein 41","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["EVI5L",12.98966246,3.825884755,1.762035394,5.742882533,{"v":8.56e-11,"d":"8.56E-11"},{"v":9.9e-10,"d":"9.90E-10"},"ENSG00000142459","H9FPL6,EVI5-like protein isoform 1","XP_014978193.1,-;XP_014978192.1,-","PF00566,Rab-GTPase-TBC domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain;IPR031214,Ecotropic viral integration site 5 protein","ENOG410YWJY,-;KOG4436,Predicted GTPase activator NB4S/EVI5 (contains TBC domain)/Calmodulin-binding protein Pollux (contains PTB and TBC domains)","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0043087,biological_process,regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity","-"]
["PLK1",28.73467304,8.46693356,1.762012568,6.484581419,{"v":1.69e-12,"d":"1.69E-12"},{"v":2.9100000000000002E-11,"d":"2.91E-11"},"ENSG00000166851","B2R841,Serine/threonine-protein kinase PLK","-","PF00069,Protein kinase domain;PF00659,POLO box duplicated region","IPR036947,POLO box domain superfamily;IPR033702,Polo-like kinase 1, catalytic domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR033701,First polo-box domain;IPR000959,POLO box domain;IPR033695,Second polo-box domain;IPR000719,Protein kinase domain","KOG0575,Polo-like serine/threonine protein kinase;ENOG410XQBP,-","GO:0016301,molecular_function,kinase activity;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["NCOA2",12.8606482,3.791039261,1.761377236,6.400547519,2.38E-12,{"v":3.92e-11,"d":"3.92E-11"},"ENSG00000140396","H2QWA2,Nuclear receptor coactivator 2","-","PF07469,omain of unknown function (DUF1518);PF16279,omain of unknown function (DUF4927);PF14598,PAS domain;PF00989,PAS fold;PF08815,Nuclear receptor coactivator;PF08832,Steroid receptor coactivator;PF16665,Unstructured region on nuclear receptor coactivator protein","IPR014920,Nuclear receptor coactivator, Ncoa-type, interlocking;IPR000014,PAS domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR009110,Nuclear receptor coactivator, interlocking;IPR035965,PAS domain superfamily;IPR028822,Nuclear receptor coactivator 2;IPR037077,Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily;IPR032565,Domain of unknown function DUF4927;IPR013767,PAS fold;IPR017426,Nuclear receptor coactivator;IPR014935,Nuclear receptor coactivator, receptor-binding domain;IPR010011,Domain of unknown function DUF1518","ENOG410XPF9,-;ENOG410IQ5S,-","GO:0046983,molecular_function,protein dimerization activity;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:0032870,biological_process,cellular response to hormone stimulus;GO:0003713,molecular_function,transcription coactivator activity;GO:0016922,molecular_function,ligand-dependent nuclear receptor binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0035257,molecular_function,nuclear hormone receptor binding;GO:0005634,cellular_component,nucleus;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity","K11255,ko04919,Thyroid hormone signaling pathway"]
["CRK",26.35865671,7.77099124,1.761005309,6.145561385,{"v":1.09e-11,"d":"1.09E-11"},{"v":1.55e-10,"d":"1.55E-10"},"ENSG00000167193","H9FQ57,Adapter molecule crk isoform a","XP_002808155.2,-","PF07653,Variant SH3 domain;PF00018,SH3 domain;PF00017,SH2 domain","IPR035457,CRK, N-terminal SH3 domain;IPR036860,SH2 domain superfamily;IPR000980,SH2 domain;IPR035458,CRK, C-terminal SH3 domain;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain","ENOG4110574,-;KOG4792,Crk family adapters","GO:0043393,biological_process,regulation of protein binding;GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:2000146,biological_process,negative regulation of cell motility;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:0043621,molecular_function,protein self-association;GO:0061045,biological_process,negative regulation of wound healing;GO:0032991,cellular_component,protein-containing complex;GO:0048013,biological_process,ephrin receptor signaling pathway;GO:0042169,molecular_function,SH2 domain binding;GO:0005070,molecular_function,SH3/SH2 adaptor activity;GO:0043087,biological_process,regulation of GTPase activity;GO:0046875,molecular_function,ephrin receptor binding;GO:0045309,molecular_function,protein phosphorylated amino acid binding;GO:0017124,molecular_function,SH3 domain binding;GO:0071538,biological_process,SH2 domain-mediated complex assembly;GO:0009967,biological_process,positive regulation of signal transduction;GO:1990782,molecular_function,protein tyrosine kinase binding;GO:0009966,biological_process,regulation of signal transduction;GO:0008360,biological_process,regulation of cell shape;GO:1900026,biological_process,positive regulation of substrate adhesion-dependent cell spreading;GO:0015629,cellular_component,actin cytoskeleton","K04438,ko04910,Insulin signaling pathway;K04438,ko05206,MicroRNAs in cancer;K04438,ko05200,Pathways in cancer;K04438,ko05100,Bacterial invasion of epithelial cells;K04438,ko04062,Chemokine signaling pathway;K04438,ko05220,Chronic myeloid leukemia;K04438,ko05131,Shigellosis;K04438,ko04510,Focal adhesion;K04438,ko04015,Rap1 signaling pathway;K04438,ko04722,Neurotrophin signaling pathway;K04438,ko04666,Fc gamma R-mediated phagocytosis;K04438,ko04012,ErbB signaling pathway;K04438,ko04810,Regulation of actin cytoskeleton;K04438,ko04010,MAPK signaling pathway;K04438,ko05211,Renal cell carcinoma"]
["ZNF740",6.131046452,1.807698583,1.759844738,5.20711303,{"v":2.66e-09,"d":"2.66E-09"},{"v":2.22E-8,"d":"2.22E-08"},"ENSG00000139651","G1S7L4,Zinc finger protein 740","XP_003252120.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["FGF12",7.554816315,2.22748773,1.759844738,5.20711303,{"v":2.66e-09,"d":"2.66E-09"},{"v":2.22E-8,"d":"2.22E-08"},"ENSG00000114279","G1R4X8,Fibroblast growth factor","XP_012366252.1,-","PF00167,ibroblast growth factor","IPR028254,Fibroblast growth factor 12;IPR008996,Cytokine IL1/FGF;IPR002209,Fibroblast growth factor family","ENOG4111IPH,-;KOG3885,Fibroblast growth factor","GO:0008543,biological_process,fibroblast growth factor receptor signaling pathway;GO:0008083,molecular_function,growth factor activity;GO:0010469,biological_process,regulation of signaling receptor activity","-"]
["FZD1",12.58405768,3.717566015,1.75781643,5.851598805,{"v":6.64e-11,"d":"6.64E-11"},{"v":7.88e-10,"d":"7.88E-10"},"ENSG00000157240","B2RC95,cDNA, FLJ95923, highly similar to Homo sapiens frizzled homolog 1","-","PF01392,z domain;PF01534,rizzled/Smoothened family membrane region","IPR015526,Frizzled/secreted frizzled-related protein;IPR017981,GPCR, family 2-like;IPR026548,Frizzled-1;IPR036790,Frizzled cysteine-rich domain superfamily;IPR000539,Frizzled/Smoothened, transmembrane domain;IPR020067,Frizzled domain","ENOG410XRC8,-;KOG3577,Smoothened and related G-protein-coupled receptors","GO:0042813,molecular_function,Wnt-activated receptor activity;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0016055,biological_process,Wnt signaling pathway;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0016020,cellular_component,membrane;GO:0007275,biological_process,multicellular organism development;GO:0016021,cellular_component,integral component of membrane","-"]
["STEAP3",6.818781024,2.011086467,1.757731764,4.396566044,{"v":6.23e-07,"d":"6.23E-07"},{"v":3.08e-06,"d":"3.08E-06"},"ENSG00000115107","K6ZGM4,STEAP family member 3","XP_016805070.1,metalloreductase STEAP3 isoform X1","PF03807,NADP oxidoreductase coenzyme F420-dependent;PF01794,erric reductase like transmembrane component","IPR036291,NAD(P)-binding domain superfamily;IPR013130,Ferric reductase transmembrane component-like domain;IPR028939,Pyrroline-5-carboxylate reductase, catalytic, N-terminal","COG2085,Predicted dinucleotide-binding enzymes;ENOG410IF4F,-","GO:0005737,cellular_component,cytoplasm;GO:0009306,biological_process,protein secretion;GO:0005771,cellular_component,multivesicular body;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K10142,ko04115,p53 signaling pathway"]
["RP11-611O2.5",31.15719104,9.182924575,1.757696118,4.064519432,{"v":2.99e-06,"d":"2.99E-06"},{"v":1.27E-5,"d":"1.27E-05"},"-","-","-","-","-","-","-","-"]
["THUMPD3",4.558880702,1.343633885,1.757696118,4.064519432,{"v":2.99e-06,"d":"2.99E-06"},{"v":1.27E-5,"d":"1.27E-05"},"ENSG00000134077","A0A024R2F4,THUMP domain containing 3, isoform CRA_a","NP_001107564.1,-;NP_056268.2,THUMP domain-containing protein 3;XP_005265078.1,-;XP_006713149.1,-;XP_005265081.1,-;XP_011531872.1,-;XP_005265079.1,-;XP_005265080.1,-","PF01170,Putative RNA methylase family UPF0020;PF02926,THUMP domain","IPR000241,Putative RNA methylase domain;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR004114,THUMP domain","ENOG410IEVP,-;COG0116,Predicted N6-adenine-specific DNA methylase","GO:0003723,molecular_function,RNA binding;GO:0005829,cellular_component,cytosol;GO:0005730,cellular_component,nucleolus","-"]
["SMTN",2.063459571,0.607850562,1.757669897,3.864247466,{"v":1.31E-5,"d":"1.31E-05"},{"v":4.84e-05,"d":"4.84E-05"},"ENSG00000183963","A0A087X1R1,Smoothelin","NP_001193946.1,smoothelin isoform d;XP_016884402.1,-","PF00307,Calponin homology (CH) domain;PF12510,Smoothelin cytoskeleton protein","IPR001715,Calponin homology domain;IPR022189,Smoothelin;IPR036872,CH domain superfamily","-","GO:0060452,biological_process,positive regulation of cardiac muscle contraction;GO:0003085,biological_process,negative regulation of systemic arterial blood pressure","-"]
["WDR92",4.366146334,1.285269704,1.757633908,3.631211527,{"v":3.67e-05,"d":"3.67E-05"},1.23125E-4,"ENSG00000243667","Q86YQ0,HZGJ","-","PF13499,-hand domain pair;PF00400,WD domain, G-beta repeat","IPR018247,EF-Hand 1, calcium-binding site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR002048,EF-hand domain;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR011992,EF-hand domain pair;IPR001680,WD40 repeat","ENOG410XPW4,-;ENOG410IFWY,-","GO:0043130,molecular_function,ubiquitin binding;GO:0005509,molecular_function,calcium ion binding","-"]
["NEURL4",1.808853619,0.531059068,1.757497814,3.005268001,0.000820646,0.002018131,"ENSG00000215041","G3QH38,Uncharacterized protein","XP_018868914.1,neuralized-like protein 4 isoform X1","PF07177,Neuralized","IPR006573,Neuralized homology repeat (NHR) domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR037962,Neuralized","-","-","-"]
["LDLRAD1",3.299446229,0.965744891,1.757343556,2.544311825,0.003819578,0.008075206,"ENSG00000203985","H2R926,Low density lipoprotein receptor class A domain containing 1","-","PF00057,Low-density lipoprotein receptor domain class A","-","-","-","-"]
["DEXI",4.550629962,1.331965224,1.757343556,2.544311825,0.003819578,0.008075206,"ENSG00000182108","H2QAK5,Uncharacterized protein","-","PF15198,examethasone-induced","-","-","-","-"]
["DCUN1D4",1.027696366,0.300805786,1.757343556,2.544311825,0.003819578,0.008075206,"ENSG00000109184","F7I655,DCN1-like protein","-","PF03556,Cullin binding","IPR005176,Potentiating neddylation domain;IPR014764,Defective-in-cullin neddylation protein","KOG3077,Uncharacterized conserved protein;ENOG410XTIJ,-","GO:0005634,cellular_component,nucleus","-"]
["RP11-304M2.5",7.860179025,2.283368955,1.756963761,1.855065481,0.023156585,0.039980573,"ENSG00000254559","A0A024R208,Blocked early in transport 1 homolog","-","-","-","-","-","-"]
["RP11-613D13.5",1.368853993,0.397649812,1.756963761,1.855065481,0.023156585,0.039980573,"-","-","-","-","-","-","-","-"]
["TMEM143",1.219060459,0.354135039,1.756963761,1.855065481,0.023156585,0.039980573,"ENSG00000161558","H2QGQ9,Transmembrane protein 143","XP_512792.2,transmembrane protein 143 isoform X1","PF12576,Protein of unknown function (DUF3754)","IPR022227,Protein of unknown function DUF3754","ENOG41105JD,-;ENOG410IJB5,-","GO:0005739,cellular_component,mitochondrion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ACTR5",1.758964039,0.510976133,1.756963761,1.855065481,0.023156585,0.039980573,"ENSG00000101442","H2QKC7,Uncharacterized protein","XP_001145158.2,actin-related protein 5","PF00022,Actin","IPR004001,Actin, conserved site;IPR004000,Actin family;IPR027664,Actin-related protein 5","KOG0681,Actin-related protein - Arp5p;ENOG410XQ7K,-","GO:0005737,cellular_component,cytoplasm;GO:0006302,biological_process,double-strand break repair;GO:0070914,biological_process,UV-damage excision repair;GO:0031011,cellular_component,Ino80 complex;GO:0005634,cellular_component,nucleus","-"]
["SHC3",0.45440052,0.132002596,1.756963761,1.855065481,0.023156585,0.039980573,"ENSG00000148082","H2QXF3,Uncharacterized protein","-","PF00640,Phosphotyrosine interaction domain (PTB/PID);PF00017,SH2 domain","-","-","-","-"]
["CD68",31.8927742,9.430240767,1.756170624,5.530019547,{"v":4.83e-10,"d":"4.83E-10"},{"v":4.79e-09,"d":"4.79E-09"},"ENSG00000129226","G3SB38,CD68 molecule","-","PF01299,Lysosome-associated membrane glycoprotein (Lamp)","IPR018134,Lysosome-associated membrane glycoprotein, conserved site;IPR002000,Lysosome-associated membrane glycoprotein","-","GO:0005765,cellular_component,lysosomal membrane;GO:0016021,cellular_component,integral component of membrane;GO:0071310,biological_process,cellular response to organic substance;GO:0005764,cellular_component,lysosome;GO:0016020,cellular_component,membrane","K06501,ko04142,Lysosome"]
["ACSL3",34.83186109,10.31868308,1.754681051,7.361645893,{"v":4.01e-14,"d":"4.01E-14"},{"v":1e-12,"d":"1.00E-12"},"ENSG00000123983","H2QJI4,Acyl-CoA synthetase long-chain family member 3","XP_001166511.1,-;XP_001166550.1,-;XP_009442680.1,-","PF00501,AMP-binding enzyme","IPR000873,AMP-dependent synthetase/ligase;IPR020845,AMP-binding, conserved site","KOG1256,Long-chain acyl-CoA synthetases (AMP-forming);COG1022,Long-chain acyl-CoA synthetases (AMP-forming)","GO:0044539,biological_process,long-chain fatty acid import;GO:0005794,cellular_component,Golgi apparatus;GO:0019901,molecular_function,protein kinase binding;GO:0001676,biological_process,long-chain fatty acid metabolic process;GO:0034379,biological_process,very-low-density lipoprotein particle assembly;GO:0003824,molecular_function,catalytic activity;GO:0004467,molecular_function,long-chain fatty acid-CoA ligase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0019904,molecular_function,protein domain specific binding;GO:0042998,biological_process,positive regulation of Golgi to plasma membrane protein transport;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:2001247,biological_process,positive regulation of phosphatidylcholine biosynthetic process;GO:0051047,biological_process,positive regulation of secretion;GO:0005811,cellular_component,lipid droplet;GO:0016021,cellular_component,integral component of membrane","K01897,ko00071,Fatty acid degradation;K01897,ko02024,Quorum sensing;K01897,ko00061,Fatty acid biosynthesis;K01897,ko01212,Fatty acid metabolism;K01897,ko04146,Peroxisome;K01897,ko03320,PPAR signaling pathway;K01897,ko04920,Adipocytokine signaling pathway"]
["CS",18.13777117,5.374049006,1.753900758,6.252890457,{"v":6.22e-12,"d":"6.22E-12"},{"v":9.32e-11,"d":"9.32E-11"},"ENSG00000062485","A0A024RB75,Citrate synthase","NP_004068.2,citrate synthase, mitochondrial precursor","PF00285,Citrate synthase, C-terminal domain","IPR010109,Citrate synthase, eukaryotic-type;IPR036969,Citrate synthase superfamily;IPR019810,Citrate synthase active site;IPR016142,Citrate synthase-like, large alpha subdomain;IPR016143,Citrate synthase-like, small alpha subdomain;IPR002020,Citrate synthase","KOG2617,Citrate synthase;COG0372,Citrate synthase","GO:0046912,molecular_function,transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer;GO:0004108,molecular_function,citrate (Si)-synthase activity;GO:0016740,molecular_function,transferase activity;GO:0005739,cellular_component,mitochondrion;GO:0006101,biological_process,citrate metabolic process;GO:0006099,biological_process,tricarboxylic acid cycle","K01647,ko01210,2-Oxocarboxylic acid metabolism;K01647,ko01230,Biosynthesis of amino acids;K01647,ko00630,Glyoxylate and dicarboxylate metabolism;K01647,ko00020,Citrate cycle (TCA cycle);K01647,ko01200,Carbon metabolism"]
["EFNA5",4.66342912,1.378909816,1.753428147,4.180752607,{"v":2.05e-06,"d":"2.05E-06"},{"v":9.07e-06,"d":"9.07E-06"},"ENSG00000184349","H2QRA5,Ephrin A5","XP_526972.2,-","PF00812,phrin","IPR001799,Ephrin receptor-binding domain;IPR008972,Cupredoxin;IPR034252,Ephrin-A ectodomain;IPR019765,Ephrin, conserved site;IPR031328,Ephrin","ENOG4111FMJ,-;KOG3858,Ephrin, ligand for Eph receptor tyrosine kinase","GO:0048013,biological_process,ephrin receptor signaling pathway;GO:0022604,biological_process,regulation of cell morphogenesis;GO:0005912,cellular_component,adherens junction;GO:0045499,molecular_function,chemorepellent activity;GO:0005886,cellular_component,plasma membrane;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0048668,biological_process,collateral sprouting;GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:1904322,biological_process,cellular response to forskolin;GO:0071372,biological_process,cellular response to follicle-stimulating hormone stimulus;GO:0043087,biological_process,regulation of GTPase activity;GO:0046875,molecular_function,ephrin receptor binding;GO:0050919,biological_process,negative chemotaxis;GO:0031362,cellular_component,anchored component of external side of plasma membrane;GO:0007411,biological_process,axon guidance;GO:0051893,biological_process,regulation of focal adhesion assembly;GO:0022407,biological_process,regulation of cell-cell adhesion;GO:1900025,biological_process,negative regulation of substrate adhesion-dependent cell spreading;GO:0005169,molecular_function,neurotrophin TRKB receptor binding;GO:0016020,cellular_component,membrane;GO:0048672,biological_process,positive regulation of collateral sprouting;GO:0070507,biological_process,regulation of microtubule cytoskeleton organization;GO:0005604,cellular_component,basement membrane;GO:0071944,cellular_component,cell periphery;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0031290,biological_process,retinal ganglion cell axon guidance;GO:0061178,biological_process,regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0046658,cellular_component,anchored component of plasma membrane","-"]
["SPEN",24.84632632,7.369593055,1.753019252,7.749294586,1.27E-14,3.55E-13,"ENSG00000065526","G3R8N9,Spen family transcriptional repressor","XP_004024776.2,msx2-interacting protein isoform X1","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF07744,SPOC domain","IPR016194,SPOC-like, C-terminal domain superfamily;IPR034174,SHARP, RNA recognition motif 3;IPR010912,Spen paralogue/orthologue C-terminal, metazoa;IPR012921,Spen paralogue and orthologue SPOC, C-terminal;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034173,SHARP, RNA recognition motif 2;IPR000504,RNA recognition motif domain;IPR034175,SHARP, RNA recognition motif 4;IPR035979,RNA-binding domain superfamily;IPR034172,SHARP, RNA recognition motif 1","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["BTN3A1",4.19525766,1.240478159,1.752796629,3.997169493,{"v":4.82e-06,"d":"4.82E-06"},{"v":1.97e-05,"d":"1.97E-05"},"ENSG00000026950","H2QSH4,Butyrophilin subfamily 3 member A3","XP_016810530.1,-;XP_009448928.1,butyrophilin subfamily 3 member A1 isoform X1","PF13765,SPRY-associated domain;PF07686,Immunoglobulin V-set domain;PF00622,SPRY domain","IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR003877,SPRY domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR013106,Immunoglobulin V-set domain;IPR006574,SPRY-associated;IPR037954,Butyrophilin subfamily 3, PRY/SPRY domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["FAM83F",1.217075612,0.359871988,1.751955398,3.786468366,{"v":1.24E-5,"d":"1.24E-05"},{"v":4.62e-05,"d":"4.62E-05"},"ENSG00000133477","G3QVF6,Family with sequence similarity 83 member F","XP_004063557.2,protein FAM83F","PF07894,Protein of unknown function (DUF1669)","IPR012461,FAM83","-","-","-"]
["MFN2",27.74267935,8.236060856,1.751228715,6.499318886,1.95E-12,{"v":3.29e-11,"d":"3.29E-11"},"ENSG00000116688","H2PY17,Mitofusin 2","XP_009446684.1,-;XP_514395.3,mitofusin-2 isoform X1;XP_003307856.1,-;XP_016809672.1,-","PF04799,fzo-like conserved region;PF00350,ynamin family","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR027094,Mitofusin family;IPR027089,Mitofusin-2;IPR030381,Dynamin-type guanine nucleotide-binding (G) domain;IPR022812,Dynamin superfamily;IPR006884,Fzo/mitofusin HR2 domain","KOG0448,Mitofusin 1 GTPase, involved in mitochondrila biogenesis;COG0699,Predicted GTPases (dynamin-related)","GO:0061734,biological_process,parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization;GO:1905461,biological_process,positive regulation of vascular associated smooth muscle cell apoptotic process;GO:0046580,biological_process,negative regulation of Ras protein signal transduction;GO:0048593,biological_process,camera-type eye morphogenesis;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0001825,biological_process,blastocyst formation;GO:0048662,biological_process,negative regulation of smooth muscle cell proliferation;GO:0008053,biological_process,mitochondrial fusion;GO:0051646,biological_process,mitochondrion localization;GO:0016021,cellular_component,integral component of membrane;GO:0005525,molecular_function,GTP binding;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0031306,cellular_component,intrinsic component of mitochondrial outer membrane;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0034497,biological_process,protein localization to phagophore assembly site;GO:1904707,biological_process,positive regulation of vascular smooth muscle cell proliferation;GO:0007006,biological_process,mitochondrial membrane organization;GO:0006626,biological_process,protein targeting to mitochondrion;GO:0015630,cellular_component,microtubule cytoskeleton","K06030,ko04214,Apoptosis - fly"]
["ELF1",21.85937417,6.489845412,1.750786132,5.999341908,{"v":2.73e-11,"d":"2.73E-11"},{"v":3.57e-10,"d":"3.57E-10"},"ENSG00000120690","A0A024RDU6,E74-like factor 1","XP_005266333.1,-;XP_016875899.1,-;XP_005266334.1,-;NP_758961.1,ETS-related transcription factor Elf-1 isoform a;XP_016875901.1,-;XP_016875902.1,-;XP_016875900.1,-;XP_016875898.1,-;XP_011533252.1,-","PF12310,Transcription factor protein N terminal;PF00178,ts-domain","IPR022084,Transcription factor Elf, N-terminal;IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000418,Ets domain","ENOG4111K4J,-;KOG3804,Transcription factor NERF and related proteins, contain ETS domain","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0050860,biological_process,negative regulation of T cell receptor signaling pathway;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001817,biological_process,regulation of cytokine production;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","K09428,ko04214,Apoptosis - fly"]
["SAP30L",7.030648269,2.085792471,1.750587161,4.988426854,{"v":1.71e-08,"d":"1.71E-08"},{"v":1.2e-07,"d":"1.20E-07"},"ENSG00000164576","G1S3M0,SAP30 like","XP_003276613.1,-","PF13867,Sin3 binding region of histone deacetylase complex subunit SAP30;PF13866,SAP30 zinc-finger","IPR024145,Histone deacetylase complex subunit SAP30/SAP30-like;IPR038291,SAP30, C-terminal domain superfamily;IPR025717,Histone deacetylase complex subunit SAP30 zinc-finger;IPR025718,Histone deacetylase complex subunit SAP30, Sin3 binding domain","ENOG4111GVC,-;ENOG410IHMG,-","GO:0003677,molecular_function,DNA binding;GO:0044378,molecular_function,non-sequence-specific DNA binding, bending;GO:0005730,cellular_component,nucleolus;GO:0010314,molecular_function,phosphatidylinositol-5-phosphate binding;GO:0042393,molecular_function,histone binding;GO:0005634,cellular_component,nucleus;GO:0031491,molecular_function,nucleosome binding;GO:0008270,molecular_function,zinc ion binding","-"]
["ZNF770",8.120534477,2.409733003,1.750041418,4.886809905,{"v":2.75e-08,"d":"2.75E-08"},{"v":1.84e-07,"d":"1.84E-07"},"ENSG00000198146","H2R3R5,Zinc finger protein 770","XP_001135452.1,zinc finger protein 770 isoform X1;XP_009427027.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["GNB5",0.999681863,0.295591741,1.749018197,3.239609799,0.000218654,0.000613202,"ENSG00000069966","A0A024R5V3,Guanine nucleotide binding protein","NP_057278.2,guanine nucleotide-binding protein subunit beta-5 isoform b","PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR016346,Guanine nucleotide-binding protein, beta subunit;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat;IPR001632,G-protein, beta subunit","ENOG410IU55,-;ENOG410YDDC,-","GO:0043209,cellular_component,myelin sheath;GO:0001750,cellular_component,photoreceptor outer segment;GO:0005886,cellular_component,plasma membrane;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0001917,cellular_component,photoreceptor inner segment;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction","K04539,ko04062,Chemokine signaling pathway;K04539,ko04724,Glutamatergic synapse;K04539,ko04727,GABAergic synapse;K04539,ko04723,Retrograde endocannabinoid signaling;K04539,ko04713,Circadian entrainment;K04539,ko04014,Ras signaling pathway;K04539,ko05032,Morphine addiction;K04539,ko04725,Cholinergic synapse;K04539,ko04726,Serotonergic synapse;K04539,ko05200,Pathways in cancer;K04539,ko04151,PI3K-Akt signaling pathway;K04539,ko04728,Dopaminergic synapse;K04539,ko05034,Alcoholism"]
["HCFC1",27.16392155,8.078774412,1.749003931,7.319057346,{"v":5.84e-14,"d":"5.84E-14"},{"v":1.4e-12,"d":"1.40E-12"},"ENSG00000172534","A6NEM2,Host cell factor 1","XP_006724878.1,host cell factor 1 isoform X1","PF13415,alactose oxidase, central domain;PF01344,Kelch motif","IPR003961,Fibronectin type III;IPR036116,Fibronectin type III superfamily;IPR015915,Kelch-type beta propeller;IPR013783,Immunoglobulin-like fold;IPR006652,Kelch repeat type 1;IPR037854,Host cell factor 1","KOG4152,Host cell transcription factor HCFC1;ENOG410Y5AC,-","GO:0071339,cellular_component,MLL1 complex;GO:0048188,cellular_component,Set1C/COMPASS complex","-"]
["LEF1",4.119342196,1.222396736,1.747390478,3.9264821,{"v":7.87e-06,"d":"7.87E-06"},{"v":3.06e-05,"d":"3.06E-05"},"ENSG00000138795","A0A024RDI7,Lymphoid enhancer-binding factor 1, isoform CRA_b","NP_057353.1,lymphoid enhancer-binding factor 1 isoform 1","PF08347,N-terminal CTNNB1 binding;PF00505,HMG (high mobility group) box","IPR027397,Catenin binding domain superfamily;IPR009071,High mobility group box domain;IPR028769,Lymphoid enhancer-binding factor 1;IPR036910,High mobility group box domain superfamily;IPR024940,Transcription factor TCF/LEF;IPR013558,CTNNB1 binding, N-teminal","ENOG41109RU,-;KOG3248,Transcription factor TCF-4","GO:0003705,molecular_function,transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0060033,biological_process,anatomical structure regression;GO:0016055,biological_process,Wnt signaling pathway;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0060325,biological_process,face morphogenesis;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0021943,biological_process,formation of radial glial scaffolds;GO:0001837,biological_process,epithelial to mesenchymal transition;GO:0033153,biological_process,T cell receptor V(D)J recombination;GO:0005634,cellular_component,nucleus;GO:0008013,molecular_function,beta-catenin binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0060561,biological_process,apoptotic process involved in morphogenesis;GO:0001944,biological_process,vasculature development;GO:0005737,cellular_component,cytoplasm;GO:0021861,biological_process,forebrain radial glial cell differentiation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0042475,biological_process,odontogenesis of dentin-containing tooth;GO:0030509,biological_process,BMP signaling pathway;GO:0045843,biological_process,negative regulation of striated muscle tissue development;GO:0030879,biological_process,mammary gland development;GO:0008301,molecular_function,DNA binding, bending;GO:0046632,biological_process,alpha-beta T cell differentiation;GO:0061153,biological_process,trachea gland development;GO:0003677,molecular_function,DNA binding;GO:0048468,biological_process,cell development;GO:0001569,biological_process,branching involved in blood vessel morphogenesis;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0042100,biological_process,B cell proliferation;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0022407,biological_process,regulation of cell-cell adhesion;GO:0060710,biological_process,chorio-allantoic fusion;GO:0002040,biological_process,sprouting angiogenesis;GO:1902262,biological_process,apoptotic process involved in blood vessel morphogenesis;GO:0003682,molecular_function,chromatin binding;GO:0021873,biological_process,forebrain neuroblast division;GO:0005667,cellular_component,transcription factor complex;GO:0001756,biological_process,somitogenesis;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0060021,biological_process,roof of mouth development;GO:0030111,biological_process,regulation of Wnt signaling pathway;GO:0048341,biological_process,paraxial mesoderm formation;GO:0045063,biological_process,T-helper 1 cell differentiation;GO:0021766,biological_process,hippocampus development;GO:0021542,biological_process,dentate gyrus development;GO:0008134,molecular_function,transcription factor binding;GO:0050909,biological_process,sensory perception of taste;GO:0043586,biological_process,tongue development","K04492,ko04310,Wnt signaling pathway;K04492,ko04520,Adherens junction;K04492,ko04916,Melanogenesis;K04492,ko05221,Acute myeloid leukemia;K04492,ko05215,Prostate cancer;K04492,ko04390,Hippo signaling pathway;K04492,ko05210,Colorectal cancer;K04492,ko05216,Thyroid cancer;K04492,ko05213,Endometrial cancer;K04492,ko05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);K04492,ko05200,Pathways in cancer;K04492,ko05217,Basal cell carcinoma"]
["C1orf210",6.578711149,1.945231534,1.746091999,2.8594315,0.000864433,0.002114503,"ENSG00000253313","H2REW9,Chromosome 1 open reading frame 210","-","PF15176,Leucine-rich repeat family 19 TM domain","-","-","-","-"]
["LACTB",2.510907881,0.74243983,1.746091999,2.8594315,0.000864433,0.002114503,"ENSG00000103642","K7CYM3,Lactamase, beta","XP_003314750.2,serine beta-lactamase-like protein LACTB, mitochondrial isoform X1","PF00144,Beta-lactamase","IPR001466,Beta-lactamase-related;IPR012338,Beta-lactamase/transpeptidase-like","ENOG410IHHD,-;COG1680,Beta-lactamase class C and other penicillin binding proteins","GO:0006508,biological_process,proteolysis;GO:0019216,biological_process,regulation of lipid metabolic process;GO:0005739,cellular_component,mitochondrion;GO:0008233,molecular_function,peptidase activity;GO:0005829,cellular_component,cytosol","-"]
["FOXO3",7.411979668,2.206773623,1.745876223,5.251650785,{"v":2.63e-09,"d":"2.63E-09"},{"v":2.19e-08,"d":"2.19E-08"},"ENSG00000118689","H2PJZ5,Forkhead box O3","XP_002817265.1,forkhead box protein O3;XP_009240402.1,-","PF00250,orkhead domain;PF16675,KIX-binding domain of forkhead box O, CR2;PF16676,Transactivation domain of FOXO protein family","IPR001766,Fork head domain;IPR032067,FOXO protein, transactivation domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036390,Winged helix DNA-binding domain superfamily;IPR032068,FOXO protein, KIX-binding domain","KOG2294,Transcription factor of the Forkhead/HNF3 family;COG5025,Transcription factor of the Forkhead/HNF3 family","GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0001547,biological_process,antral ovarian follicle growth;GO:0032991,cellular_component,protein-containing complex;GO:0006417,biological_process,regulation of translation;GO:0048854,biological_process,brain morphogenesis;GO:0006390,biological_process,mitochondrial transcription;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0019901,molecular_function,protein kinase binding;GO:2000177,biological_process,regulation of neural precursor cell proliferation;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:2000377,biological_process,regulation of reactive oxygen species metabolic process;GO:0005634,cellular_component,nucleus;GO:0034599,biological_process,cellular response to oxidative stress;GO:0008013,molecular_function,beta-catenin binding;GO:0033209,biological_process,tumor necrosis factor-mediated signaling pathway;GO:0042593,biological_process,glucose homeostasis;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0001142,-,-;GO:0030330,biological_process,DNA damage response, signal transduction by p53 class mediator;GO:0043525,biological_process,positive regulation of neuron apoptotic process;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0005759,cellular_component,mitochondrial matrix;GO:0005739,cellular_component,mitochondrion;GO:0005829,cellular_component,cytosol;GO:0001047,molecular_function,core promoter binding;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0003677,molecular_function,DNA binding;GO:0001556,biological_process,oocyte maturation;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0031490,molecular_function,chromatin DNA binding;GO:0001544,biological_process,initiation of primordial ovarian follicle growth;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0097150,biological_process,neuronal stem cell population maintenance;GO:0016020,cellular_component,membrane;GO:0045648,biological_process,positive regulation of erythrocyte differentiation;GO:0005654,cellular_component,nucleoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0001542,biological_process,ovulation from ovarian follicle;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0006351,biological_process,transcription, DNA-templated","K09408,ko04722,Neurotrophin signaling pathway;K09408,ko04068,FoxO signaling pathway;K09408,ko04151,PI3K-Akt signaling pathway;K09408,ko04211,Longevity regulating pathway;K09408,ko01521,EGFR tyrosine kinase inhibitor resistance;K09408,ko05223,Non-small cell lung cancer;K09408,ko04917,Prolactin signaling pathway;K09408,ko04152,AMPK signaling pathway;K09408,ko04213,Longevity regulating pathway - multiple species;K09408,ko04062,Chemokine signaling pathway;K09408,ko04212,Longevity regulating pathway - worm;K09408,ko05213,Endometrial cancer"]
["ATM",1.234277764,0.367055882,1.745347736,4.230857841,{"v":1.67e-06,"d":"1.67E-06"},{"v":7.57e-06,"d":"7.57E-06"},"ENSG00000149311","A0A024R3C7,Ataxia telangiectasia mutated","XP_005271619.2,-;NP_000042.3,serine-protein kinase ATM isoform a;XP_005271618.2,-;XP_016873278.1,-;XP_006718906.1,-;XP_011541142.1,-;XP_016873279.1,-","PF02259,AT domain;PF00454,Phosphatidylinositol 3- and 4-kinase;PF11640,Telomere-length maintenance and DNA damage repair;PF02260,ATC domain","IPR018936,Phosphatidylinositol 3/4-kinase, conserved site;IPR003151,PIK-related kinase, FAT;IPR003152,FATC domain;IPR000403,Phosphatidylinositol 3-/4-kinase, catalytic domain;IPR014009,PIK-related kinase;IPR021668,Telomere-length maintenance and DNA damage repair;IPR011009,Protein kinase-like domain superfamily;IPR016024,Armadillo-type fold;IPR036940,Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily;IPR015519,Serine/threonine-protein kinase ATM","KOG0892,Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair;ENOG410XNPY,-","GO:0001541,biological_process,ovarian follicle development;GO:0070192,biological_process,chromosome organization involved in meiotic cell cycle;GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:1901216,biological_process,positive regulation of neuron death;GO:0008340,biological_process,determination of adult lifespan;GO:0035264,biological_process,multicellular organism growth;GO:0001666,biological_process,response to hypoxia;GO:0004672,molecular_function,protein kinase activity;GO:0000077,biological_process,DNA damage checkpoint;GO:0007292,biological_process,female gamete generation;GO:1904262,biological_process,negative regulation of TORC1 signaling;GO:0010506,biological_process,regulation of autophagy;GO:0005524,molecular_function,ATP binding;GO:0048599,biological_process,oocyte development;GO:0045141,biological_process,meiotic telomere clustering;GO:0033151,biological_process,V(D)J recombination;GO:0016301,molecular_function,kinase activity;GO:0032212,biological_process,positive regulation of telomere maintenance via telomerase;GO:0007507,biological_process,heart development;GO:0042159,biological_process,lipoprotein catabolic process;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005737,cellular_component,cytoplasm;GO:1905843,biological_process,regulation of cellular response to gamma radiation;GO:0005634,cellular_component,nucleus;GO:0000724,biological_process,double-strand break repair via homologous recombination;GO:0010212,biological_process,response to ionizing radiation;GO:0007420,biological_process,brain development;GO:0000723,biological_process,telomere maintenance;GO:0033129,biological_process,positive regulation of histone phosphorylation;GO:0051402,biological_process,neuron apoptotic process;GO:0006915,biological_process,apoptotic process;GO:0016310,biological_process,phosphorylation;GO:0090399,biological_process,replicative senescence;GO:0008585,biological_process,female gonad development;GO:0016740,molecular_function,transferase activity;GO:0043525,biological_process,positive regulation of neuron apoptotic process;GO:1903626,biological_process,positive regulation of DNA catabolic process;GO:0002377,biological_process,immunoglobulin production;GO:0007143,biological_process,female meiotic nuclear division;GO:0009791,biological_process,post-embryonic development;GO:0005819,cellular_component,spindle;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0002331,biological_process,pre-B cell allelic exclusion;GO:0006281,biological_process,DNA repair;GO:1903978,biological_process,regulation of microglial cell activation;GO:0001756,biological_process,somitogenesis;GO:0016572,biological_process,histone phosphorylation;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:2001022,biological_process,positive regulation of response to DNA damage stimulus;GO:0007140,biological_process,male meiotic nuclear division;GO:0051726,biological_process,regulation of cell cycle;GO:0002376,biological_process,immune system process;GO:0048538,biological_process,thymus development","K04728,ko04210,Apoptosis;K04728,ko04064,NF-kappa B signaling pathway;K04728,ko04214,Apoptosis - fly;K04728,ko05206,MicroRNAs in cancer;K04728,ko01524,Platinum drug resistance;K04728,ko04068,FoxO signaling pathway;K04728,ko05202,Transcriptional misregulation in cancer;K04728,ko04110,Cell cycle;K04728,ko05166,HTLV-I infection;K04728,ko04115,p53 signaling pathway"]
["PGGT1B",2.737020752,0.813949337,1.745347736,4.230857841,{"v":1.67e-06,"d":"1.67E-06"},{"v":7.57e-06,"d":"7.57E-06"},"ENSG00000164219","G7MVK1,Geranylgeranyl transferase type-1 subunit beta","NP_001248139.1,-","PF00432,Prenyltransferase and squalene oxidase repeat","IPR001330,PFTB repeat;IPR008930,Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid","COG5029,Prenyltransferase, beta subunit;KOG0367,Protein geranylgeranyltransferase Type I, beta subunit","GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity","-"]
["SMIM10L1",11.24159603,3.34838557,1.745140666,5.167541983,{"v":4.83e-09,"d":"4.83E-09"},{"v":3.8e-08,"d":"3.80E-08"},"ENSG00000256537","A0A0G2JPJ8,Small integral membrane protein 10-like protein 1","-","PF15118,omain of unknown function (DUF4560)","IPR029367,Small integral membrane protein 10","-","-","-"]
["E2F4",39.57669088,11.80027482,1.745006431,6.539492974,{"v":2.12e-12,"d":"2.12E-12"},{"v":3.54e-11,"d":"3.54E-11"},"ENSG00000205250","G3R8D1,E2F transcription factor 4","-","PF02319,2F/DP family winged-helix DNA-binding domain;PF16421,2F transcription factor CC-MB domain","IPR003316,E2F/DP family, winged-helix DNA-binding domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR028312,Transcription factor E2F4;IPR037241,E2F-DP heterodimerization region;IPR015633,E2F Family;IPR036390,Winged helix DNA-binding domain superfamily;IPR032198,E2F transcription factor, CC-MB domain","-","GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0000278,biological_process,mitotic cell cycle;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["PDCD7",15.50076952,4.619221107,1.744308933,5.078206391,{"v":7.21e-09,"d":"7.21E-09"},{"v":5.48e-08,"d":"5.48E-08"},"ENSG00000090470","K7B1L5,Programmed cell death 7","XP_016783857.1,-","PF16021,Programmed cell death protein 7","IPR031974,Programmed cell death protein 7","ENOG41124DX,-;ENOG410IVC0,-","GO:0005689,cellular_component,U12-type spliceosomal complex","-"]
["PFKM",6.487447681,1.934311936,1.743360842,4.98294902,{"v":1.71e-08,"d":"1.71E-08"},{"v":1.2e-07,"d":"1.20E-07"},"ENSG00000152556","K7AUT0,ATP-dependent 6-phosphofructokinase","XP_016779017.1,-;XP_016779016.1,-;XP_016779019.1,-;XP_016779018.1,-","PF00365,Phosphofructokinase","IPR022953,ATP-dependent 6-phosphofructokinase;IPR035966,Phosphofructokinase superfamily;IPR009161,ATP-dependent 6-phosphofructokinase, eukaryotic-type;IPR015912,Phosphofructokinase, conserved site;IPR000023,Phosphofructokinase domain","COG0205,6-phosphofructokinase;KOG2440,Pyrophosphate-dependent phosphofructo-1-kinase","GO:0006096,biological_process,glycolytic process;GO:0046835,biological_process,carbohydrate phosphorylation;GO:0005634,cellular_component,nucleus;GO:0005980,biological_process,glycogen catabolic process;GO:0016301,molecular_function,kinase activity;GO:0042593,biological_process,glucose homeostasis;GO:0005737,cellular_component,cytoplasm;GO:0070061,molecular_function,fructose binding;GO:0003824,molecular_function,catalytic activity;GO:0005524,molecular_function,ATP binding;GO:0019900,molecular_function,kinase binding;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0005945,cellular_component,6-phosphofructokinase complex;GO:0016310,biological_process,phosphorylation;GO:0006002,biological_process,fructose 6-phosphate metabolic process;GO:0016740,molecular_function,transferase activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0093001,biological_process,glycolysis from storage polysaccharide through glucose-1-phosphate;GO:0016324,cellular_component,apical plasma membrane;GO:0008022,molecular_function,protein C-terminus binding;GO:0008152,biological_process,metabolic process;GO:0061615,biological_process,glycolytic process through fructose-6-phosphate;GO:0000166,molecular_function,nucleotide binding;GO:0061621,biological_process,canonical glycolysis;GO:0032024,biological_process,positive regulation of insulin secretion;GO:0051259,biological_process,protein complex oligomerization;GO:0046872,molecular_function,metal ion binding;GO:0003872,molecular_function,6-phosphofructokinase activity;GO:0046716,biological_process,muscle cell cellular homeostasis;GO:0008443,molecular_function,phosphofructokinase activity;GO:0097228,cellular_component,sperm principal piece;GO:0042803,molecular_function,protein homodimerization activity","-"]
["SGK1",8.460349452,2.52502855,1.743037988,5.803960545,{"v":9.81e-11,"d":"9.81E-11"},{"v":1.12e-09,"d":"1.12E-09"},"ENSG00000118515","G1RXA9,Serum/glucocorticoid regulated kinase 1","XP_003255794.1,serine/threonine-protein kinase Sgk1 isoform X1;XP_012361465.1,-","PF00433,Protein kinase C terminal domain;PF00069,Protein kinase domain","IPR036871,PX domain superfamily;IPR017892,Protein kinase, C-terminal;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XNPH,-;KOG0598,Ribosomal protein S6 kinase and related proteins","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0016607,cellular_component,nuclear speck;GO:0005829,cellular_component,cytosol;GO:0004712,molecular_function,protein serine/threonine/tyrosine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["RNF152",3.618185058,1.078651296,1.743004374,4.695157581,{"v":9.07e-08,"d":"9.07E-08"},{"v":5.38e-07,"d":"5.38E-07"},"ENSG00000176641","G3QXM6,Ring finger protein 152","-","PF14634,zinc-RING finger domain","-","-","-","-"]
["ZNF106",7.372001561,2.20088487,1.742677351,5.892903545,{"v":6.54e-11,"d":"6.54E-11"},{"v":7.77e-10,"d":"7.77E-10"},"ENSG00000103994","A0A024R9R5,Zinc finger protein 106 homolog","-","PF00400,WD domain, G-beta repeat","IPR013087,Zinc finger C2H2-type;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR036322,WD40-repeat-containing domain superfamily;IPR017986,WD40-repeat-containing domain","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["RP11-26J3.4",196.7171472,58.79488144,1.741972551,7.615480642,{"v":2.47e-14,"d":"2.47E-14"},{"v":6.41e-13,"d":"6.41E-13"},"ENSG00000276418","H0YC42,Uncharacterized protein","-","PF10246,Mitochondrial ribosomal protein MRP-S35;PF04201,Tumour protein D52 family","IPR007327,Tumour protein D52;IPR019375,Ribosomal protein S28, mitochondrial","ENOG4111M9H,-;KOG4010,Coiled-coil protein TPD52","-","-"]
["BCAT2",4.589609661,1.367363377,1.741394742,3.852106648,{"v":1.7E-5,"d":"1.70E-05"},{"v":6.18e-05,"d":"6.18E-05"},"ENSG00000105552","M0QXF9,Branched-chain-amino-acid aminotransferase","-","PF01063,Amino-transferase class IV","IPR033939,Branched-chain aminotransferase;IPR018300,Aminotransferase, class IV, conserved site;IPR001544,Aminotransferase class IV;IPR005786,Branched-chain amino acid aminotransferase II;IPR036038,Aminotransferase-like, PLP-dependent enzymes","COG0115,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase;KOG0975,Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily","GO:0052654,molecular_function,L-leucine transaminase activity;GO:0008652,biological_process,cellular amino acid biosynthetic process;GO:0004084,molecular_function,branched-chain-amino-acid transaminase activity;GO:0008152,biological_process,metabolic process;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0009081,biological_process,branched-chain amino acid metabolic process;GO:0008483,molecular_function,transaminase activity;GO:0052656,molecular_function,L-isoleucine transaminase activity;GO:0052655,molecular_function,L-valine transaminase activity;GO:0009082,biological_process,branched-chain amino acid biosynthetic process","-"]
["EFNB2",33.90766925,10.13619265,1.741326238,6.632942832,{"v":1.2e-12,"d":"1.20E-12"},2.15E-11,"ENSG00000125266","G3SE00,Ephrin B2","-","PF00812,phrin","IPR001799,Ephrin receptor-binding domain;IPR008972,Cupredoxin;IPR034255,Ephrin-B ectodomain;IPR019765,Ephrin, conserved site;IPR031328,Ephrin","-","GO:0046875,molecular_function,ephrin receptor binding;GO:0048013,biological_process,ephrin receptor signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K05463,ko04360,Axon guidance"]
["VARS",14.60452135,4.364535282,1.741204361,5.874372928,{"v":7.72e-11,"d":"7.72E-11"},{"v":9.03e-10,"d":"9.03E-10"},"ENSG00000204394","A0A024RCN6,VARS","NP_006286.1,valine--tRNA ligase","PF00043,lutathione S-transferase, C-terminal domain;PF08264,Anticodon-binding domain of tRNA;PF00133,tRNA synthetases class I (I, L, M and V)","IPR002303,Valine-tRNA ligase;IPR002300,Aminoacyl-tRNA synthetase, class Ia;IPR009008,Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain;IPR013155,Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding;IPR036282,Glutathione S-transferase, C-terminal domain superfamily;IPR010987,Glutathione S-transferase, C-terminal-like;IPR009080,Aminoacyl-tRNA synthetase, class Ia, anticodon-binding;IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR001412,Aminoacyl-tRNA synthetase, class I, conserved site;IPR037118,Valyl-tRNA synthetase, tRNA-binding arm superfamily;IPR004046,Glutathione S-transferase, C-terminal;IPR033705,Valyl tRNA synthetase, anticodon-binding domain","KOG0432,Valyl-tRNA synthetase;COG0525,Valyl-tRNA synthetase;KOG0867,Glutathione S-transferase","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0002161,molecular_function,aminoacyl-tRNA editing activity;GO:0006438,biological_process,valyl-tRNA aminoacylation;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0006412,biological_process,translation;GO:0016874,molecular_function,ligase activity;GO:0005829,cellular_component,cytosol;GO:0004832,molecular_function,valine-tRNA ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0106074,biological_process,aminoacyl-tRNA metabolism involved in translational fidelity;GO:0005739,cellular_component,mitochondrion","K01873,ko00970,Aminoacyl-tRNA biosynthesis"]
["ARSD-AS1",8.14814224,2.409290037,1.740272342,2.337830679,0.012098155,0.022562941,"-","-","-","-","-","-","-","-"]
["SEMA4B",8.91407625,2.665831626,1.739638199,5.376204343,{"v":1.35e-09,"d":"1.35E-09"},{"v":1.21e-08,"d":"1.21E-08"},"ENSG00000185033","J3KNP4,Semaphorin-4B","NP_064595.2,semaphorin-4B isoform 1 precursor;NP_945119.1,-","PF01437,Plexin repeat;PF01403,Sema domain","IPR001627,Sema domain;IPR036352,Sema domain superfamily;IPR016201,PSI domain;IPR002165,Plexin repeat;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR027231,Semaphorin","KOG3611,Semaphorins;ENOG410XQZC,-","GO:0045202,cellular_component,synapse;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K06521,ko04360,Axon guidance"]
["ERCC3",9.176273686,2.744917389,1.73943438,5.494676105,{"v":6.4e-10,"d":"6.40E-10"},{"v":6.17E-9,"d":"6.17E-09"},"ENSG00000163161","A8K359,cDNA FLJ76102, highly similar to Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 3","-","PF04851,Type III restriction enzyme, res subunit;PF13625,Helicase conserved C-terminal domain;PF16203,RCC3/RAD25/XPB C-terminal helicase","IPR006935,Helicase/UvrB, N-terminal;IPR001161,Helicase XPB/Ssl2;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR032438,ERCC3/RAD25/XPB helicase, C-terminal domain;IPR032830,Helicase XPB/Ssl2, N-terminal domain;IPR001650,Helicase, C-terminal","KOG1123,RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3'-5' helicase subunit SSL2;COG1061,DNA or RNA helicases of superfamily II","GO:0016787,molecular_function,hydrolase activity;GO:0003677,molecular_function,DNA binding;GO:0032508,biological_process,DNA duplex unwinding;GO:0006289,biological_process,nucleotide-excision repair;GO:0006367,biological_process,transcription initiation from RNA polymerase II promoter;GO:0005524,molecular_function,ATP binding;GO:0004003,molecular_function,ATP-dependent DNA helicase activity","-"]
["PLEKHA8P1",5.220029056,1.553576679,1.738846907,3.117008808,0.000577021,0.001471632,"ENSG00000134297","J3KQS5,Pleckstrin homology domain-containing family A member 8","-","PF08718,lycolipid transfer protein (GLTP);PF00169,PH domain","IPR011993,PH-like domain superfamily;IPR036497,Glycolipid transfer protein superfamily;IPR001849,Pleckstrin homology domain;IPR014830,Glycolipid transfer protein domain","KOG3221,Glycolipid transfer protein;ENOG410YFEA,-","GO:0005737,cellular_component,cytoplasm;GO:0005794,cellular_component,Golgi apparatus;GO:0120009,biological_process,intermembrane lipid transfer;GO:0120013,molecular_function,intermembrane lipid transfer activity;GO:0005654,cellular_component,nucleoplasm","-"]
["GBA2",2.521438145,0.750426378,1.738846907,3.117008808,0.000577021,0.001471632,"ENSG00000070610","H2QX87,Non-lysosomal glucosylceramidase","XP_520565.1,non-lysosomal glucosylceramidase isoform X4","PF04685,lycosyl-hydrolase family 116, catalytic region;PF12215,beta-glucosidase 2, glycosyl-hydrolase family 116 N-term","IPR014551,Beta-glucosidase GBA2-type;IPR012341,Six-hairpin glycosidase-like superfamily;IPR008928,Six-hairpin glycosidase superfamily;IPR006775,Glycosyl-hydrolase family 116, catalytic region;IPR024462,Glycosyl-hydrolase family 116, N-terminal","COG4354,Predicted bile acid beta-glucosidase;KOG2119,Predicted bile acid beta-glucosidase","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0006629,biological_process,lipid metabolic process;GO:0005794,cellular_component,Golgi apparatus;GO:0016787,molecular_function,hydrolase activity;GO:0016020,cellular_component,membrane;GO:0003824,molecular_function,catalytic activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0004348,molecular_function,glucosylceramidase activity;GO:0004553,molecular_function,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0000139,cellular_component,Golgi membrane;GO:0008422,molecular_function,beta-glucosidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0008152,biological_process,metabolic process;GO:0016139,biological_process,glycoside catabolic process;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0008206,biological_process,bile acid metabolic process;GO:0006680,biological_process,glucosylceramide catabolic process;GO:0021954,biological_process,central nervous system neuron development","-"]
["CDKN1B",33.87460628,10.14113117,1.738766074,5.973932741,{"v":4.49e-11,"d":"4.49E-11"},{"v":5.54e-10,"d":"5.54E-10"},"ENSG00000111276","G3RVM3,Cyclin dependent kinase inhibitor 1B","-","PF02234,Cyclin-dependent kinase inhibitor","-","-","-","-"]
["KLF13",2.448042735,0.731313885,1.738021594,3.986125511,{"v":6.25e-06,"d":"6.25E-06"},{"v":2.48E-5,"d":"2.48E-05"},"ENSG00000169926","X5DNR2,Kruppel-like factor 13","NP_057079.2,Krueppel-like factor 13 isoform 1","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003677,molecular_function,DNA binding;GO:0045647,biological_process,negative regulation of erythrocyte differentiation;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding","-"]
["KSR1",2.425124888,0.725042517,1.737845989,4.279273031,{"v":1.09e-06,"d":"1.09E-06"},{"v":5.08e-06,"d":"5.08E-06"},"ENSG00000141068","A0A0A0MQW1,Kinase suppressor of Ras 1","-","PF13543,SAM like domain present in kinase suppressor RAS 1;PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR025561,Kinase suppressor of RAS, SAM-like domain;IPR000719,Protein kinase domain","ENOG410Y4UP,-;KOG0193,Serine/threonine protein kinase RAF","GO:0035556,biological_process,intracellular signal transduction;GO:0046872,molecular_function,metal ion binding;GO:0004672,molecular_function,protein kinase activity;GO:0005622,cellular_component,intracellular;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding","-"]
["HK2",5.599736276,1.675060488,1.737726828,4.522479383,{"v":2.4e-07,"d":"2.40E-07"},{"v":1.29e-06,"d":"1.29E-06"},"ENSG00000159399","H2QI73,Hexokinase 2","XP_001162535.2,hexokinase-2 isoform X2","PF03727,Hexokinase;PF00349,Hexokinase","IPR022672,Hexokinase, N-terminal;IPR019807,Hexokinase, binding site;IPR022673,Hexokinase, C-terminal;IPR001312,Hexokinase","KOG1369,Hexokinase;COG5026,Hexokinase","GO:0006096,biological_process,glycolytic process;GO:0051156,biological_process,glucose 6-phosphate metabolic process;GO:0019158,molecular_function,mannokinase activity;GO:0046835,biological_process,carbohydrate phosphorylation;GO:0008865,molecular_function,fructokinase activity;GO:0016301,molecular_function,kinase activity;GO:0072655,biological_process,establishment of protein localization to mitochondrion;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0072656,biological_process,maintenance of protein location in mitochondrion;GO:0005524,molecular_function,ATP binding;GO:0008637,biological_process,apoptotic mitochondrial changes;GO:0005829,cellular_component,cytosol;GO:0005975,biological_process,carbohydrate metabolic process;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0016310,biological_process,phosphorylation;GO:0004396,molecular_function,hexokinase activity;GO:1904925,biological_process,positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization;GO:0001678,biological_process,cellular glucose homeostasis;GO:0016740,molecular_function,transferase activity;GO:0005536,molecular_function,glucose binding;GO:0000166,molecular_function,nucleotide binding;GO:0004340,molecular_function,glucokinase activity;GO:0016773,molecular_function,phosphotransferase activity, alcohol group as acceptor","K00844,ko00052,Galactose metabolism;K00844,ko00010,Glycolysis / Gluconeogenesis;K00844,ko04910,Insulin signaling pathway;K00844,ko00524,Neomycin, kanamycin and gentamicin biosynthesis;K00844,ko04930,Type II diabetes mellitus;K00844,ko00051,Fructose and mannose metabolism;K00844,ko00521,Streptomycin biosynthesis;K00844,ko04973,Carbohydrate digestion and absorption;K00844,ko00500,Starch and sucrose metabolism;K00844,ko04066,HIF-1 signaling pathway;K00844,ko01200,Carbon metabolism;K00844,ko00520,Amino sugar and nucleotide sugar metabolism;K00844,ko05230,Central carbon metabolism in cancer"]
["COA7",27.02427584,8.103081595,1.736683874,6.212350822,{"v":1.2e-11,"d":"1.20E-11"},{"v":1.69e-10,"d":"1.69E-10"},"ENSG00000162377","H2PZ14,Sel1 repeat containing 1","NP_001229523.1,-","PF08238,Sel1 repeat","IPR006597,Sel1-like repeat;IPR011990,Tetratricopeptide-like helical domain superfamily","KOG4014,Uncharacterized conserved protein (contains TPR repeat);COG0790,FOG: TPR repeat, SEL1 subfamily","GO:0005739,cellular_component,mitochondrion;GO:0005634,cellular_component,nucleus","-"]
["KIF1B",4.931452227,1.479293206,1.735779521,5.852617836,{"v":1.03e-10,"d":"1.03E-10"},{"v":1.18e-09,"d":"1.18E-09"},"ENSG00000054523","G7NU57,Uncharacterized protein","-","PF00225,Kinesin motor domain;PF12423,Kinesin protein 1B;PF12473,Kinesin protein;PF00498,HA domain;PF16183,Kinesin-associated;PF00169,PH domain","IPR022140,Kinesin-like KIF1-type;IPR019821,Kinesin motor domain, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR032405,Kinesin-associated;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR008984,SMAD/FHA domain superfamily;IPR000253,Forkhead-associated (FHA) domain;IPR001752,Kinesin motor domain;IPR036961,Kinesin motor domain superfamily;IPR027640,Kinesin-like protein;IPR022164,Kinesin-like","-","GO:0003777,molecular_function,microtubule motor activity;GO:0030705,biological_process,cytoskeleton-dependent intracellular transport;GO:0008017,molecular_function,microtubule binding;GO:0007270,biological_process,neuron-neuron synaptic transmission;GO:0003774,molecular_function,motor activity;GO:0047497,biological_process,mitochondrion transport along microtubule;GO:1904115,cellular_component,axon cytoplasm;GO:0005739,cellular_component,mitochondrion;GO:0030659,cellular_component,cytoplasmic vesicle membrane;GO:0008089,biological_process,anterograde axonal transport;GO:0016887,molecular_function,ATPase activity;GO:0007018,biological_process,microtubule-based movement;GO:0005875,cellular_component,microtubule associated complex;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0007274,biological_process,neuromuscular synaptic transmission","-"]
["WDR48",3.361481757,1.006444877,1.735226443,4.108649468,{"v":4.13e-06,"d":"4.13E-06"},{"v":1.71e-05,"d":"1.71E-05"},"ENSG00000114742","I3MXA5,WD repeat domain 48","XP_005317449.1,-","PF11816,omain of unknown function (DUF3337);PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR021772,Protein of unknown function DUF3337;IPR001680,WD40 repeat","ENOG410XRJ5,-;KOG0308,Conserved WD40 repeat-containing protein","GO:0007283,biological_process,spermatogenesis;GO:1902525,biological_process,regulation of protein monoubiquitination;GO:0035264,biological_process,multicellular organism growth;GO:0048568,biological_process,embryonic organ development;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0048872,biological_process,homeostasis of number of cells;GO:0072520,biological_process,seminiferous tubule development;GO:0007338,biological_process,single fertilization;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005634,cellular_component,nucleus;GO:0008584,biological_process,male gonad development;GO:0050679,biological_process,positive regulation of epithelial cell proliferation;GO:0043588,biological_process,skin development;GO:0048705,biological_process,skeletal system morphogenesis;GO:0016579,biological_process,protein deubiquitination;GO:0000724,biological_process,double-strand break repair via homologous recombination","-"]
["CENPBD1",7.182650167,2.149395777,1.734707349,3.773633969,{"v":1.64e-05,"d":"1.64E-05"},{"v":5.94E-5,"d":"5.94E-05"},"ENSG00000177946","W5PMZ4,Uncharacterized protein","XP_014955904.1,CENPB DNA-binding domain-containing protein 1 isoform X1","PF03184,superfamily endonuclease;PF03221,Tc5 transposase DNA-binding domain;PF04218,CENP-B N-terminal DNA-binding domain","IPR006600,HTH CenpB-type DNA-binding domain;IPR009057,Homeobox-like domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR004875,DDE superfamily endonuclease domain;IPR007889,DNA binding HTH domain, Psq-type","-","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["CDK12",8.626126001,2.590934624,1.734191064,6.182543875,{"v":1.74e-11,"d":"1.74E-11"},2.39E-10,"ENSG00000167258","K7CGF7,Cyclin-dependent kinase 12","XP_016786255.1,-;XP_016786254.1,cyclin-dependent kinase 12 isoform X1;XP_016786257.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0030332,molecular_function,cyclin binding;GO:0016301,molecular_function,kinase activity;GO:0008353,molecular_function,RNA polymerase II carboxy-terminal domain kinase activity;GO:0016310,biological_process,phosphorylation;GO:0005634,cellular_component,nucleus;GO:0001650,cellular_component,fibrillar center;GO:0043405,biological_process,regulation of MAP kinase activity;GO:2000737,biological_process,negative regulation of stem cell differentiation;GO:0070816,biological_process,phosphorylation of RNA polymerase II C-terminal domain;GO:0004672,molecular_function,protein kinase activity;GO:0016607,cellular_component,nuclear speck;GO:0046777,biological_process,protein autophosphorylation;GO:0019901,molecular_function,protein kinase binding;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0002944,cellular_component,cyclin K-CDK12 complex","-"]
["SYTL4",1.918094873,0.573455141,1.733791698,3.334925309,0.000159196,4.61228E-4,"ENSG00000102362","A0A024RCF8,Synaptotagmin-like 4","XP_016885460.1,-;NP_001167539.1,-;XP_011529370.1,-;NP_001123368.1,-;XP_005262286.1,-;NP_542775.2,synaptotagmin-like protein 4","PF02318,YVE-type zinc finger;PF00168,C2 domain","IPR001565,Synaptotagmin;IPR011011,Zinc finger, FYVE/PHD-type;IPR037303,Synaptotagmin-like protein 4/5, C2A domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR010911,Rab-binding domain;IPR028694,Synaptotagmin-like protein 4;IPR000008,C2 domain;IPR035892,C2 domain superfamily","ENOG410XRME,-;KOG1028,Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis","GO:0019898,cellular_component,extrinsic component of membrane;GO:0017137,molecular_function,Rab GTPase binding;GO:0046676,biological_process,negative regulation of insulin secretion;GO:0006887,biological_process,exocytosis;GO:0030141,cellular_component,secretory granule;GO:0005815,cellular_component,microtubule organizing center;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0042043,molecular_function,neurexin family protein binding;GO:0006886,biological_process,intracellular protein transport;GO:0005543,molecular_function,phospholipid binding;GO:0005654,cellular_component,nucleoplasm","-"]
["NSMAF",14.32849538,4.305067162,1.733471717,5.86847892,{"v":9.84e-11,"d":"9.84E-11"},{"v":1.12e-09,"d":"1.12E-09"},"ENSG00000035681","K7B3T1,Neutral sphingomyelinase","-","PF00400,WD domain, G-beta repeat;PF02893,RAM domain;PF02138,Beige/BEACH domain","IPR004182,GRAM domain;IPR017986,WD40-repeat-containing domain;IPR036372,BEACH domain superfamily;IPR000409,BEACH domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR023362,PH-BEACH domain;IPR001680,WD40 repeat","KOG1786,Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins;ENOG410XNQC,-","-","-"]
["CAMK4",2.902100985,0.87157063,1.73254764,4.764714341,{"v":5.61e-08,"d":"5.61E-08"},{"v":3.5e-07,"d":"3.50E-07"},"ENSG00000152495","B2R747,cDNA, FLJ93281, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase IV","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0032,Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily;ENOG410XRMJ,-","GO:0016301,molecular_function,kinase activity;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0004672,molecular_function,protein kinase activity","-"]
["SLC30A1",3.990926811,1.197162751,1.731818026,3.914867374,{"v":1.02e-05,"d":"1.02E-05"},{"v":3.89e-05,"d":"3.89E-05"},"ENSG00000170385","K7CV20,Solute carrier family 30","XP_016793699.1,zinc transporter 1","PF01545,Cation efflux family","IPR027469,Cation efflux transmembrane domain superfamily;IPR002524,Cation efflux protein;IPR036837,Cation efflux protein, cytoplasmic domain superfamily","COG1230,Co/Zn/Cd efflux system component;KOG1483,Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily)","GO:0031965,cellular_component,nuclear membrane;GO:0005794,cellular_component,Golgi apparatus;GO:0098655,biological_process,cation transmembrane transport;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0006882,biological_process,cellular zinc ion homeostasis;GO:0008324,molecular_function,cation transmembrane transporter activity;GO:0090281,biological_process,negative regulation of calcium ion import;GO:0005783,cellular_component,endoplasmic reticulum;GO:0065009,biological_process,regulation of molecular function;GO:0006812,biological_process,cation transport;GO:0055085,biological_process,transmembrane transport;GO:0001701,biological_process,in utero embryonic development;GO:0005737,cellular_component,cytoplasm;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0019855,molecular_function,calcium channel inhibitor activity;GO:0006829,biological_process,zinc ion transport;GO:0071584,biological_process,negative regulation of zinc ion transmembrane import","K14688,ko04978,Mineral absorption"]
["RP11-471B22.2",29.28675125,8.737691869,1.731744217,2.696775303,0.002545854,0.005608977,"-","-","-","-","-","-","-","-"]
["EMC3-AS1",2.365650343,0.705790943,1.731744217,2.696775303,0.002545854,0.005608977,"ENSG00000180385","A0A0L0G057,Non-specific serine/threonine protein kinase","XP_014156117.1,CAMK/CAMKL/MARK protein kinase","PF02149,Kinase associated domain 1;PF00069,Protein kinase domain","IPR028375,KA1 domain/Ssp2, C-terminal;IPR033624,Serine/threonine-protein kinase MARK/par1;IPR001772,Kinase associated domain 1 (KA1);IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0030010,biological_process,establishment of cell polarity;GO:0016301,molecular_function,kinase activity;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0004672,molecular_function,protein kinase activity","-"]
["SUN1",15.66179436,4.716178619,1.730936463,6.9230518,{"v":4.66e-13,"d":"4.66E-13"},{"v":9.13e-12,"d":"9.13E-12"},"ENSG00000164828","E9PHI4,SUN domain-containing protein 1","-","PF09387,Mitochondrial RNA binding protein MRP;PF07738,Sad1 / UNC-like C-terminal","IPR012919,SUN domain;IPR032680,SUN domain-containing protein 1, N-terminal;IPR008979,Galactose-binding-like domain superfamily;IPR018539,SUN domain-containing protein 1","ENOG410YM6S,-;KOG2687,Spindle pole body protein, contains UNC-84 domain","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0034993,cellular_component,meiotic nuclear membrane microtubule tethering complex;GO:0016020,cellular_component,membrane;GO:0031965,cellular_component,nuclear membrane;GO:0005639,cellular_component,integral component of nuclear inner membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["EIF2AK3",9.22048043,2.773742818,1.730707801,5.067901875,{"v":1.02E-8,"d":"1.02E-08"},{"v":7.54E-8,"d":"7.54E-08"},"ENSG00000172071","G1QS89,Eukaryotic translation initiation factor 2 alpha kinase 3","XP_003268838.1,eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1","PF00069,Protein kinase domain","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XS0B,-;KOG1033,eIF-2alpha kinase PEK/EIF2AK3","GO:0006983,biological_process,ER overload response;GO:0051260,biological_process,protein homooligomerization;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding;GO:0006468,biological_process,protein phosphorylation;GO:1902235,biological_process,regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0010575,biological_process,positive regulation of vascular endothelial growth factor production;GO:0004694,molecular_function,eukaryotic translation initiation factor 2alpha kinase activity;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0042149,biological_process,cellular response to glucose starvation;GO:0010628,biological_process,positive regulation of gene expression;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0070417,biological_process,cellular response to cold;GO:0019903,molecular_function,protein phosphatase binding;GO:0001525,biological_process,angiogenesis;GO:0031018,biological_process,endocrine pancreas development;GO:0036492,biological_process,eiF2alpha phosphorylation in response to endoplasmic reticulum stress;GO:0016020,cellular_component,membrane;GO:0045943,biological_process,positive regulation of transcription by RNA polymerase I;GO:0019899,molecular_function,enzyme binding;GO:0001503,biological_process,ossification;GO:0046777,biological_process,protein autophosphorylation;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0034198,biological_process,cellular response to amino acid starvation","K08860,ko05162,Measles;K08860,ko05164,Influenza A;K08860,ko05010,Alzheimer's disease;K08860,ko05160,Hepatitis C;K08860,ko05169,Epstein-Barr virus infection;K08860,ko05168,Herpes simplex infection;K08860,ko04214,Apoptosis - fly;K08860,ko04141,Protein processing in endoplasmic reticulum;K08860,ko04932,Non-alcoholic fatty liver disease (NAFLD);K08860,ko04210,Apoptosis"]
["RNF44",11.53737455,3.473464082,1.73010446,5.4413037,{"v":1.15E-9,"d":"1.15E-09"},{"v":1.05E-8,"d":"1.05E-08"},"ENSG00000146083","A0A024R7Q1,Ring finger protein 44, isoform CRA_b","NP_055716.1,RING finger protein 44;XP_005265898.1,-;XP_005265897.1,-;XP_011532768.1,-","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG0800,FOG: Predicted E3 ubiquitin ligase;ENOG41121N2,-","-","-"]
["PCDHA4",1.219103424,0.365695809,1.730063839,3.523830502,{"v":8.68e-05,"d":"8.68E-05"},0.000265058,"ENSG00000204967","Q3V7B3,Protocadherin alpha","-","PF08266,Cadherin-like;PF00028,Cadherin domain;PF15974,Cadherin C-terminal cytoplasmic tail, catenin-binding region","IPR031904,Cadherin, C-terminal catenin-binding domain;IPR002126,Cadherin;IPR013164,Cadherin, N-terminal;IPR015919,Cadherin-like;IPR020894,Cadherin conserved site","-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["MAP7D1",90.10060531,27.16541937,1.729523277,8.276491388,{"v":6.81e-15,"d":"6.81E-15"},{"v":2.04e-13,"d":"2.04E-13"},"ENSG00000116871","D3DPS3,Arginine/proline rich coiled-coil 1, isoform CRA_b","XP_006710822.1,MAP7 domain-containing protein 1 isoform X1","PF05672,MAP7 (E-MAP-115) family","IPR008604,Microtubule-associated protein 7 family","ENOG410XTH2,-;ENOG410IH56,-","GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["SPRY1",6.051848265,1.818974462,1.72944722,4.043385624,{"v":4.98e-06,"d":"4.98E-06"},{"v":2.03e-05,"d":"2.03E-05"},"ENSG00000164056","H2QQ50,Sprouty homolog 1, antagonist of FGF signaling","XP_001155923.1,-;XP_517428.1,protein sprouty homolog 1","PF05210,Sprouty protein (Spry)","IPR030783,Protein sprouty homologue 1;IPR007875,Sprouty","ENOG410IJJB,-;ENOG410Z8F4,-","GO:0040037,biological_process,negative regulation of fibroblast growth factor receptor signaling pathway;GO:0051387,biological_process,negative regulation of neurotrophin TRK receptor signaling pathway;GO:0005794,cellular_component,Golgi apparatus;GO:0060449,biological_process,bud elongation involved in lung branching;GO:0046580,biological_process,negative regulation of Ras protein signal transduction;GO:0001759,biological_process,organ induction;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0000132,biological_process,establishment of mitotic spindle orientation;GO:0001657,biological_process,ureteric bud development;GO:0034260,biological_process,negative regulation of GTPase activity;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0009966,biological_process,regulation of signal transduction;GO:0043407,biological_process,negative regulation of MAP kinase activity;GO:0007275,biological_process,multicellular organism development;GO:0001656,biological_process,metanephros development;GO:0005654,cellular_component,nucleoplasm","-"]
["TICRR",4.663285405,1.403937637,1.728931076,4.723785971,{"v":9.62e-08,"d":"9.62E-08"},{"v":5.65e-07,"d":"5.65E-07"},"ENSG00000140534","G3QZK0,TOPBP1 interacting checkpoint and replication regulator","-","PF15292,Treslin N-terminus","IPR032746,Treslin, N-terminal;IPR026153,Treslin","-","GO:0033314,biological_process,mitotic DNA replication checkpoint;GO:0006260,biological_process,DNA replication;GO:0010212,biological_process,response to ionizing radiation;GO:0030174,biological_process,regulation of DNA-dependent DNA replication initiation;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","-"]
["HCG18",2.96867835,0.894612079,1.727705285,4.798271251,{"v":7.7e-08,"d":"7.70E-08"},{"v":4.63E-7,"d":"4.63E-07"},"ENSG00000231074","A0A024RCK0,HCG2006649, isoform CRA_a","-","-","-","-","-","-"]
["MAPRE3",12.56293917,3.789111825,1.726600862,4.869083848,{"v":4.02e-08,"d":"4.02E-08"},{"v":2.59e-07,"d":"2.59E-07"},"ENSG00000084764","K7CLN8,Microtubule-associated protein, RP/EB family, member 3","XP_016799295.1,-;XP_016799302.1,-;XP_016799309.1,-","PF03271,B1-like C-terminal motif;PF00307,Calponin homology (CH) domain","IPR001715,Calponin homology domain;IPR027738,EB3;IPR036872,CH domain superfamily;IPR004953,EB1, C-terminal;IPR027328,Microtubule-associated protein RP/EB;IPR036133,EB1, C-terminal domain superfamily","COG5217,Microtubule-binding protein involved in cell cycle control;KOG3000,Microtubule-binding protein involved in cell cycle control","GO:0030496,cellular_component,midbody;GO:0019901,molecular_function,protein kinase binding;GO:0005737,cellular_component,cytoplasm;GO:0045860,biological_process,positive regulation of protein kinase activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:1903033,biological_process,positive regulation of microtubule plus-end binding;GO:0005874,cellular_component,microtubule;GO:0008022,molecular_function,protein C-terminus binding;GO:0008017,molecular_function,microtubule binding;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0042802,molecular_function,identical protein binding;GO:0045737,biological_process,positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0035371,cellular_component,microtubule plus-end","-"]
["CDH23",0.604859997,0.181440526,1.726567344,2.98276864,1.136595E-3,0.002716269,"ENSG00000107736","A0A0A0MQS6,Cadherin-23","-","PF00028,Cadherin domain","IPR020894,Cadherin conserved site;IPR002126,Cadherin;IPR015919,Cadherin-like;IPR033030,Cadherin-23","KOG1219,Uncharacterized conserved protein, contains laminin, cadherin and EGF domains;ENOG410XPEI,-","GO:0007155,biological_process,cell adhesion;GO:0007605,biological_process,sensory perception of sound;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0060122,biological_process,inner ear receptor cell stereocilium organization;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0007626,biological_process,locomotory behavior;GO:0032420,cellular_component,stereocilium;GO:0016021,cellular_component,integral component of membrane","-"]
["TTLL1",6.245378321,1.873433076,1.726567344,2.98276864,1.136595E-3,0.002716269,"ENSG00000100271","H2QLU6,Tubulin tyrosine ligase-like family, member 1","-","PF03133,Tubulin-tyrosine ligase family","IPR027750,Tubulin polyglutamylase TTLL1;IPR004344,Tubulin-tyrosine ligase/Tubulin polyglutamylase","ENOG410XQDM,-;KOG2157,Predicted tubulin-tyrosine ligase","GO:0018095,biological_process,protein polyglutamylation;GO:0035082,biological_process,axoneme assembly;GO:1905419,biological_process,sperm flagellum movement involved in flagellated sperm motility;GO:0003351,biological_process,epithelial cilium movement;GO:0007288,biological_process,sperm axoneme assembly;GO:0006464,biological_process,cellular protein modification process","-"]
["YAP1",15.50128966,4.683880251,1.725437944,6.011925931,{"v":5.35e-11,"d":"5.35E-11"},{"v":6.48e-10,"d":"6.48E-10"},"ENSG00000137693","A0A0D9S1T1,Yes associated protein 1","XP_008018831.1,-","PF00397,WW domain","IPR001202,WW domain;IPR036020,WW domain superfamily","-","GO:0072091,biological_process,regulation of stem cell proliferation;GO:0035329,biological_process,hippo signaling;GO:0001570,biological_process,vasculogenesis;GO:0070064,molecular_function,proline-rich region binding;GO:0033148,biological_process,positive regulation of intracellular estrogen receptor signaling pathway;GO:0003713,molecular_function,transcription coactivator activity;GO:0071148,cellular_component,TEAD-1-YAP complex;GO:0003714,molecular_function,transcription corepressor activity;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005634,cellular_component,nucleus;GO:0050847,biological_process,progesterone receptor signaling pathway;GO:0000902,biological_process,cell morphogenesis;GO:0072307,biological_process,regulation of metanephric nephron tubule epithelial cell differentiation;GO:0046622,biological_process,positive regulation of organ growth;GO:0065003,biological_process,protein-containing complex assembly;GO:0005737,cellular_component,cytoplasm;GO:0060487,biological_process,lung epithelial cell differentiation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:2000737,biological_process,negative regulation of stem cell differentiation;GO:0071480,biological_process,cellular response to gamma radiation;GO:0030857,biological_process,negative regulation of epithelial cell differentiation;GO:0005829,cellular_component,cytosol;GO:0048339,biological_process,paraxial mesoderm development;GO:0042127,biological_process,regulation of cell proliferation;GO:0033613,molecular_function,activating transcription factor binding;GO:0010837,biological_process,regulation of keratinocyte proliferation;GO:0060449,biological_process,bud elongation involved in lung branching;GO:0071300,biological_process,cellular response to retinoic acid;GO:0001076,molecular_function,transcription factor activity, RNA polymerase II transcription factor binding;GO:0035019,biological_process,somatic stem cell population maintenance;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0071149,cellular_component,TEAD-2-YAP complex;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0048368,biological_process,lateral mesoderm development;GO:0008022,molecular_function,protein C-terminus binding;GO:0016020,cellular_component,membrane;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0060242,biological_process,contact inhibition;GO:1902459,biological_process,positive regulation of stem cell population maintenance;GO:0050767,biological_process,regulation of neurogenesis;GO:0060828,biological_process,regulation of canonical Wnt signaling pathway;GO:0032570,biological_process,response to progesterone;GO:0005667,cellular_component,transcription factor complex;GO:0008283,biological_process,cell proliferation;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:1903507,biological_process,negative regulation of nucleic acid-templated transcription;GO:0003143,biological_process,embryonic heart tube morphogenesis;GO:2001237,biological_process,negative regulation of extrinsic apoptotic signaling pathway;GO:0003682,molecular_function,chromatin binding;GO:0030903,biological_process,notochord development;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway;GO:0030216,biological_process,keratinocyte differentiation","-"]
["TGFB1",31.46090251,9.512156837,1.724591675,6.073076164,{"v":3.28e-11,"d":"3.28E-11"},4.18E-10,"ENSG00000105329","G3SE85,Transforming growth factor beta 1","XP_004060838.1,-","PF00019,Transforming growth factor beta like domain;PF00688,TGF-beta propeptide","IPR017948,Transforming growth factor beta, conserved site;IPR001111,TGF-beta, propeptide;IPR029034,Cystine-knot cytokine;IPR003939,Transforming growth factor, beta 1;IPR016319,Transforming growth factor-beta;IPR015615,Transforming growth factor-beta-related;IPR001839,Transforming growth factor-beta, C-terminal","-","GO:0010469,biological_process,regulation of signaling receptor activity;GO:0003179,biological_process,heart valve morphogenesis;GO:0060389,biological_process,pathway-restricted SMAD protein phosphorylation;GO:0045216,biological_process,cell-cell junction organization;GO:0032967,biological_process,positive regulation of collagen biosynthetic process;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:0005114,molecular_function,type II transforming growth factor beta receptor binding;GO:0045599,biological_process,negative regulation of fat cell differentiation;GO:0007435,biological_process,salivary gland morphogenesis;GO:0017015,biological_process,regulation of transforming growth factor beta receptor signaling pathway;GO:1900126,biological_process,negative regulation of hyaluronan biosynthetic process;GO:0005634,cellular_component,nucleus;GO:0005576,cellular_component,extracellular region;GO:0032930,biological_process,positive regulation of superoxide anion generation;GO:0002028,biological_process,regulation of sodium ion transport;GO:0001657,biological_process,ureteric bud development;GO:0048642,biological_process,negative regulation of skeletal muscle tissue development;GO:0010629,biological_process,negative regulation of gene expression;GO:0006754,biological_process,ATP biosynthetic process;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0060390,biological_process,regulation of SMAD protein signal transduction;GO:0019049,biological_process,evasion or tolerance of host defenses by virus;GO:0072562,cellular_component,blood microparticle;GO:0030335,biological_process,positive regulation of cell migration;GO:0031334,biological_process,positive regulation of protein complex assembly;GO:0002513,biological_process,tolerance induction to self antigen;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0050714,biological_process,positive regulation of protein secretion;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0051098,biological_process,regulation of binding;GO:0005902,cellular_component,microvillus;GO:1903799,biological_process,negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:0060391,biological_process,positive regulation of SMAD protein signal transduction;GO:0043552,biological_process,positive regulation of phosphatidylinositol 3-kinase activity;GO:0043539,molecular_function,protein serine/threonine kinase activator activity;GO:0070306,biological_process,lens fiber cell differentiation;GO:0034713,molecular_function,type I transforming growth factor beta receptor binding;GO:0071560,biological_process,cellular response to transforming growth factor beta stimulus;GO:0048535,biological_process,lymph node development;GO:0019899,molecular_function,enzyme binding;GO:0007050,biological_process,cell cycle arrest;GO:0050868,biological_process,negative regulation of T cell activation;GO:0042110,biological_process,T cell activation;GO:0043536,biological_process,positive regulation of blood vessel endothelial cell migration;GO:0009611,biological_process,response to wounding;GO:0007183,biological_process,SMAD protein complex assembly;GO:0042130,biological_process,negative regulation of T cell proliferation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:1902895,biological_process,positive regulation of pri-miRNA transcription by RNA polymerase II;GO:0060325,biological_process,face morphogenesis;GO:1903077,biological_process,negative regulation of protein localization to plasma membrane;GO:0043537,biological_process,negative regulation of blood vessel endothelial cell migration;GO:0001837,biological_process,epithelial to mesenchymal transition;GO:0007182,biological_process,common-partner SMAD protein phosphorylation;GO:0005615,cellular_component,extracellular space;GO:0032700,biological_process,negative regulation of interleukin-17 production;GO:0045786,biological_process,negative regulation of cell cycle;GO:0045589,biological_process,regulation of regulatory T cell differentiation;GO:0043406,biological_process,positive regulation of MAP kinase activity;GO:0071158,biological_process,positive regulation of cell cycle arrest;GO:0030879,biological_process,mammary gland development;GO:0001843,biological_process,neural tube closure;GO:1900182,biological_process,positive regulation of protein localization to nucleus;GO:0016202,biological_process,regulation of striated muscle tissue development;GO:0035066,biological_process,positive regulation of histone acetylation;GO:0010628,biological_process,positive regulation of gene expression;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0034714,molecular_function,type III transforming growth factor beta receptor binding;GO:0030214,biological_process,hyaluronan catabolic process;GO:0042307,biological_process,positive regulation of protein import into nucleus;GO:0008284,biological_process,positive regulation of cell proliferation;GO:2000679,biological_process,positive regulation of transcription regulatory region DNA binding;GO:0010468,biological_process,regulation of gene expression;GO:0021915,biological_process,neural tube development;GO:0005515,molecular_function,protein binding;GO:0048298,biological_process,positive regulation of isotype switching to IgA isotypes;GO:2000249,biological_process,regulation of actin cytoskeleton reorganization;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0045591,biological_process,positive regulation of regulatory T cell differentiation;GO:0097191,biological_process,extrinsic apoptotic signaling pathway;GO:0042482,biological_process,positive regulation of odontogenesis;GO:0032740,biological_process,positive regulation of interleukin-17 production;GO:0022408,biological_process,negative regulation of cell-cell adhesion;GO:0008083,molecular_function,growth factor activity;GO:0045930,biological_process,negative regulation of mitotic cell cycle;GO:0005578,,;GO:0001775,biological_process,cell activation;GO:0007492,biological_process,endoderm development;GO:0031293,biological_process,membrane protein intracellular domain proteolysis;GO:0032667,biological_process,regulation of interleukin-23 production;GO:0008354,biological_process,germ cell migration;GO:0009986,cellular_component,cell surface;GO:0031663,biological_process,lipopolysaccharide-mediated signaling pathway;GO:0048146,biological_process,positive regulation of fibroblast proliferation;GO:1990402,biological_process,embryonic liver development;GO:0006796,biological_process,phosphate-containing compound metabolic process;GO:0060751,biological_process,branch elongation involved in mammary gland duct branching;GO:0006954,biological_process,inflammatory response;GO:1903911,biological_process,positive regulation of receptor clustering;GO:0032270,biological_process,positive regulation of cellular protein metabolic process;GO:0010862,biological_process,positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0043011,biological_process,myeloid dendritic cell differentiation;GO:0042127,biological_process,regulation of cell proliferation;GO:0045662,biological_process,negative regulation of myoblast differentiation;GO:0061035,biological_process,regulation of cartilage development;GO:0000165,biological_process,MAPK cascade;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030501,biological_process,positive regulation of bone mineralization;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0070723,biological_process,response to cholesterol;GO:0002062,biological_process,chondrocyte differentiation;GO:0006468,biological_process,protein phosphorylation;GO:0030279,biological_process,negative regulation of ossification;GO:0060762,biological_process,regulation of branching involved in mammary gland duct morphogenesis;GO:0000060,biological_process,protein import into nucleus, translocation;GO:0032355,biological_process,response to estradiol;GO:0042306,biological_process,regulation of protein import into nucleus;GO:2000727,biological_process,positive regulation of cardiac muscle cell differentiation;GO:0010800,biological_process,positive regulation of peptidyl-threonine phosphorylation;GO:0045596,biological_process,negative regulation of cell differentiation;GO:0001934,biological_process,positive regulation of protein phosphorylation;GO:0085029,biological_process,extracellular matrix assembly;GO:0045066,biological_process,regulatory T cell differentiation;GO:0001570,biological_process,vasculogenesis;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0010936,biological_process,negative regulation of macrophage cytokine production;GO:0006611,biological_process,protein export from nucleus;GO:0055010,biological_process,ventricular cardiac muscle tissue morphogenesis;GO:0060744,biological_process,mammary gland branching involved in thelarche;GO:1901666,biological_process,positive regulation of NAD+ ADP-ribosyltransferase activity;GO:0060965,biological_process,negative regulation of gene silencing by miRNA;GO:0031065,biological_process,positive regulation of histone deacetylation;GO:0008156,biological_process,negative regulation of DNA replication;GO:0051897,biological_process,positive regulation of protein kinase B signaling;GO:0007507,biological_process,heart development;GO:0043117,biological_process,positive regulation of vascular permeability;GO:1903800,biological_process,positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:0005737,cellular_component,cytoplasm;GO:0050921,biological_process,positive regulation of chemotaxis;GO:0051101,biological_process,regulation of DNA binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0043932,biological_process,ossification involved in bone remodeling;GO:0043029,biological_process,T cell homeostasis;GO:0007093,biological_process,mitotic cell cycle checkpoint;GO:0042802,molecular_function,identical protein binding;GO:0002460,biological_process,adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;GO:0030217,biological_process,T cell differentiation;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0003823,molecular_function,antigen binding;GO:0032943,biological_process,mononuclear cell proliferation;GO:0043491,biological_process,protein kinase B signaling;GO:0010763,biological_process,positive regulation of fibroblast migration;GO:0035307,biological_process,positive regulation of protein dephosphorylation;GO:0050680,biological_process,negative regulation of epithelial cell proliferation;GO:0032801,biological_process,receptor catabolic process;GO:0032570,biological_process,response to progesterone;GO:0030308,biological_process,negative regulation of cell growth;GO:0008283,biological_process,cell proliferation;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0071363,biological_process,cellular response to growth factor stimulus;GO:0014003,biological_process,oligodendrocyte development;GO:0005160,molecular_function,transforming growth factor beta receptor binding;GO:0007219,biological_process,Notch signaling pathway;GO:1905313,biological_process,transforming growth factor beta receptor signaling pathway involved in heart development;GO:0016477,biological_process,cell migration","K13375,ko05140,Leishmaniasis;K13375,ko04672,Intestinal immune network for IgA production;K13375,ko05161,Hepatitis B;K13375,ko05145,Toxoplasmosis;K13375,ko05321,Inflammatory bowel disease (IBD);K13375,ko04350,TGF-beta signaling pathway;K13375,ko05144,Malaria;K13375,ko05152,Tuberculosis;K13375,ko04068,FoxO signaling pathway;K13375,ko05146,Amoebiasis;K13375,ko04932,Non-alcoholic fatty liver disease (NAFLD);K13375,ko05323,Rheumatoid arthritis;K13375,ko05212,Pancreatic cancer;K13375,ko05414,Dilated cardiomyopathy;K13375,ko05200,Pathways in cancer;K13375,ko05410,Hypertrophic cardiomyopathy (HCM);K13375,ko04144,Endocytosis;K13375,ko05210,Colorectal cancer;K13375,ko05142,Chagas disease (American trypanosomiasis);K13375,ko04390,Hippo signaling pathway;K13375,ko04060,Cytokine-cytokine receptor interaction;K13375,ko04380,Osteoclast differentiation;K13375,ko04010,MAPK signaling pathway;K13375,ko05220,Chronic myeloid leukemia;K13375,ko04110,Cell cycle;K13375,ko05211,Renal cell carcinoma;K13375,ko05205,Proteoglycans in cancer;K13375,ko05166,HTLV-I infection;K13375,ko04933,AGE-RAGE signaling pathway in diabetic complications"]
["ENOX2",9.378538105,2.833266527,1.724043413,4.758301207,{"v":6.84e-08,"d":"6.84E-08"},{"v":4.17e-07,"d":"4.17E-07"},"ENSG00000165675","H2PWS2,Ecto-NOX disulfide-thiol exchanger 2","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR000504,RNA recognition motif domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR035979,RNA-binding domain superfamily;IPR034140,Ecto-NOX disulfide-thiol exchanger, RNA recognition motif","ENOG4110UUI,-;ENOG410ITYH,-","GO:0009897,cellular_component,external side of plasma membrane;GO:0003676,molecular_function,nucleic acid binding;GO:0003723,molecular_function,RNA binding;GO:0015035,molecular_function,protein disulfide oxidoreductase activity;GO:0007624,biological_process,ultradian rhythm;GO:0055114,biological_process,oxidation-reduction process","-"]
["DHX57",2.854874633,0.861732291,1.723093676,3.9749932,{"v":8.09e-06,"d":"8.09E-06"},{"v":3.14e-05,"d":"3.14E-05"},"ENSG00000163214","H2QHS5,Uncharacterized protein","XP_515423.2,putative ATP-dependent RNA helicase DHX57 isoform X1;XP_009440626.1,-;XP_009440625.1,-","PF00271,Helicase conserved C-terminal domain;PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar);PF00270,AD/DEAH box helicase;PF07717,Oligonucleotide/oligosaccharide-binding (OB)-fold;PF04408,Helicase associated domain (HA2);PF05773,RWD domain","IPR011709,Domain of unknown function DUF1605;IPR009060,UBA-like superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR007502,Helicase-associated domain;IPR036855,Zinc finger, CCCH-type superfamily;IPR006575,RWD domain;IPR011545,DEAD/DEAH box helicase domain;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR000571,Zinc finger, CCCH-type;IPR015940,Ubiquitin-associated domain;IPR001650,Helicase, C-terminal","KOG0920,ATP-dependent RNA helicase A;COG1643,HrpA-like helicases","GO:0004386,molecular_function,helicase activity;GO:0004004,molecular_function,ATP-dependent RNA helicase activity;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0003723,molecular_function,RNA binding;GO:0016787,molecular_function,hydrolase activity;GO:0005739,cellular_component,mitochondrion;GO:0006396,biological_process,RNA processing;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["TRAF7",54.43227656,16.49631067,1.721851754,7.323845844,{"v":1.3E-13,"d":"1.30E-13"},{"v":2.87e-12,"d":"2.87E-12"},"ENSG00000131653","G3RP85,TNF receptor associated factor 7","XP_004057038.2,E3 ubiquitin-protein ligase TRAF7 isoform X1","PF00400,WD domain, G-beta repeat;PF13445,RING-type zinc-finger","IPR019775,WD40 repeat, conserved site;IPR008974,TRAF-like;IPR027370,RING-type zinc-finger, LisH dimerisation motif;IPR036322,WD40-repeat-containing domain superfamily;IPR001293,Zinc finger, TRAF-type;IPR001841,Zinc finger, RING-type;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain;IPR017907,Zinc finger, RING-type, conserved site","-","GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding","-"]
["KLHL9",2.66154979,0.803377974,1.720594838,3.424265807,1.56954E-4,0.000455931,"ENSG00000198642","H2PS21,Kelch like family member 9","XP_009242662.1,-","PF01344,Kelch motif;PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch","IPR011705,BTB/Kelch-associated;IPR011333,SKP1/BTB/POZ domain superfamily;IPR015915,Kelch-type beta propeller;IPR017096,BTB-kelch protein;IPR006652,Kelch repeat type 1;IPR000210,BTB/POZ domain","KOG4441,Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes;ENOG410XNX8,-","GO:0030496,cellular_component,midbody;GO:0031463,cellular_component,Cul3-RING ubiquitin ligase complex;GO:0032465,biological_process,regulation of cytokinesis;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016567,biological_process,protein ubiquitination","K10447,ko04120,Ubiquitin mediated proteolysis"]
["FEM1B",8.282399043,2.510830997,1.720065095,5.385871564,{"v":2.46e-09,"d":"2.46E-09"},{"v":2.07E-8,"d":"2.07E-08"},"ENSG00000169018","G1RRY5,Fem-1 homolog B","-","PF12796,Ankyrin repeats (3 copies);PF00023,Ankyrin repeat","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0508,Ankyrin repeat protein;COG0666,FOG: Ankyrin repeat","-","-"]
["LRRC59",92.59386847,28.10592352,1.719773228,8.112804384,{"v":1.33e-14,"d":"1.33E-14"},{"v":3.72e-13,"d":"3.72E-13"},"ENSG00000108829","A0A096P4I0,Leucine rich repeat containing 59","XP_017806042.1,-;XP_003912782.1,-","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","-","GO:0042645,cellular_component,mitochondrial nucleoid;GO:0045296,molecular_function,cadherin binding;GO:0016021,cellular_component,integral component of membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane","-"]
["PTPN14",9.090231623,2.760227358,1.718862305,6.809141785,1.09E-12,1.97E-11,"ENSG00000152104","A8K6H6,Tyrosine-protein phosphatase non-receptor type","NP_005392.2,tyrosine-protein phosphatase non-receptor type 14","PF00102,Protein-tyrosine phosphatase;PF09379,RM N-terminal domain;PF00373,RM central domain;PF09380,RM C-terminal PH-like domain","IPR019747,FERM conserved site;IPR029021,Protein-tyrosine phosphatase-like;IPR014392,Protein-tyrosine phosphatase, non-receptor type-14, -21;IPR035963,FERM superfamily, second domain;IPR018979,FERM, N-terminal;IPR000387,Tyrosine specific protein phosphatases domain;IPR000299,FERM domain;IPR019748,FERM central domain;IPR000242,PTP type protein phosphatase;IPR011993,PH-like domain superfamily;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR016130,Protein-tyrosine phosphatase, active site;IPR029071,Ubiquitin-like domain superfamily;IPR018980,FERM, C-terminal PH-like domain","KOG0792,Protein tyrosine phosphatase PTPMEG, contains FERM domain;COG5599,Protein tyrosine phosphatase","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0005856,cellular_component,cytoskeleton;GO:0016791,molecular_function,phosphatase activity","-"]
["CCZ1B",5.90729175,1.791489585,1.718701937,4.863125277,{"v":4.86e-08,"d":"4.86E-08"},{"v":3.07e-07,"d":"3.07E-07"},"ENSG00000146574","H2QU52,Uncharacterized protein","XP_519566.2,vacuolar fusion protein CCZ1 homolog isoform X1","PF08217,ungal domain of unknown function (DUF1712)","IPR013176,Protein of unknown function DUF1712, fungi","KOG2622,Putative myrosinase precursor;ENOG410XRE1,-","GO:0016192,biological_process,vesicle-mediated transport;GO:0031982,cellular_component,vesicle","-"]
["MID1",3.602138836,1.09279901,1.717427565,4.507219745,{"v":3.71e-07,"d":"3.71E-07"},{"v":1.9E-6,"d":"1.90E-06"},"ENSG00000101871","A0A096MTA9,Midline 1","-","PF13445,RING-type zinc-finger;PF00643,B-box zinc finger;PF00041,ibronectin type III domain;PF13765,SPRY-associated domain;PF00622,SPRY domain","IPR017903,COS domain;IPR017907,Zinc finger, RING-type, conserved site;IPR000315,B-box-type zinc finger;IPR003649,B-box, C-terminal;IPR001841,Zinc finger, RING-type;IPR027727,Midline-1;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR027370,RING-type zinc-finger, LisH dimerisation motif;IPR013783,Immunoglobulin-like fold","-","GO:0046872,molecular_function,metal ion binding;GO:0008270,molecular_function,zinc ion binding;GO:0005622,cellular_component,intracellular","-"]
["PCBD1",12.06427008,3.654239164,1.717250595,3.760679732,{"v":2.16E-5,"d":"2.16E-05"},{"v":7.65e-05,"d":"7.65E-05"},"ENSG00000166228","A0A1U7QCB0,pterin-4-alpha-carbinolamine dehydratase","XP_005070899.1,-","-","IPR001533,Pterin 4 alpha carbinolamine dehydratase;IPR036428,Pterin 4 alpha carbinolamine dehydratase superfamily","-","GO:0006729,biological_process,tetrahydrobiopterin biosynthetic process;GO:0008124,molecular_function,4-alpha-hydroxytetrahydrobiopterin dehydratase activity","-"]
["VGLL3",1.531518949,0.463893504,1.717250595,3.760679732,{"v":2.16E-5,"d":"2.16E-05"},{"v":7.65e-05,"d":"7.65E-05"},"ENSG00000206538","H2PA03,Vestigial like family member 3","XP_002813454.1,-","PF07545,Vestigial/Tondu family","IPR011520,Vestigial familiy;IPR006627,TDU repeat","ENOG4111HDH,-;ENOG410II4C,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["ANKRD11",54.33184515,16.52913125,1.716663824,9.232510458,1.59E-15,{"v":5.52e-14,"d":"5.52E-14"},"ENSG00000167522","K7DIJ4,Ankyrin repeat domain 11","-","PF12796,Ankyrin repeats (3 copies);PF13637,Ankyrin repeats (many copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","ENOG410IJ47,-;ENOG4110UQU,-","-","-"]
["AP2A1",7.765104225,2.360255779,1.716389502,5.49977389,{"v":9.21e-10,"d":"9.21E-10"},{"v":8.53e-09,"d":"8.53E-09"},"ENSG00000196961","H9FQK8,AP-2 complex subunit alpha","XP_014979894.1,-","PF02883,Adaptin C-terminal domain;PF02296,Alpha adaptin AP2, C-terminal domain;PF01602,Adaptin N terminal region","IPR013041,Clathrin adaptor, appendage, Ig-like subdomain superfamily;IPR008152,Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain;IPR002553,Clathrin/coatomer adaptor, adaptin-like, N-terminal;IPR012295,TBP domain superfamily;IPR016024,Armadillo-type fold;IPR003164,Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain;IPR009028,Coatomer/calthrin adaptor appendage, C-terminal subdomain;IPR011989,Armadillo-like helical;IPR017104,Adaptor protein complex AP-2, alpha subunit","ENOG410XNQE,-;KOG1077,Vesicle coat complex AP-2, alpha subunit","GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0072583,biological_process,clathrin-dependent endocytosis;GO:0005905,cellular_component,clathrin-coated pit;GO:0030131,cellular_component,clathrin adaptor complex;GO:0035615,molecular_function,clathrin adaptor activity;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0030117,cellular_component,membrane coat;GO:0006897,biological_process,endocytosis;GO:0008565,molecular_function,protein transporter activity;GO:0006886,biological_process,intracellular protein transport","-"]
["RP11-770G2.5",5.231401668,1.569269373,1.716171844,2.095721467,0.014306174,0.026219024,"-","-","-","-","-","-","-","-"]
["CTD-3032J10.3",8.682962387,2.604637878,1.716171844,2.095721467,0.014306174,0.026219024,"ENSG00000269480","F7HJ82,Uncharacterized protein","-","-","-","-","GO:0048741,biological_process,skeletal muscle fiber development","-"]
["ABCG2",1.126564221,0.337936721,1.716171844,2.095721467,0.014306174,0.026219024,"ENSG00000118777","A0A024RDD4,ATP-binding cassette, sub-family G","XP_011530722.1,-;XP_005263412.1,-;NP_004818.2,ATP-binding cassette sub-family G member 2 isoform 1","PF01061,ABC-2 type transporter;PF00005,ABC transporter","IPR030256,ATP-binding cassette subfamily G member 2;IPR003593,AAA+ ATPase domain;IPR013525,ABC-2 type transporter;IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG0842,ABC-type multidrug transport system, permease component;ENOG410IN8P,-","GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0055085,biological_process,transmembrane transport;GO:0005634,cellular_component,nucleus;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016887,molecular_function,ATPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","K05681,ko02010,ABC transporters;K05681,ko04976,Bile secretion"]
["SLC16A10",0.486035716,0.145796674,1.716171844,2.095721467,0.014306174,0.026219024,"ENSG00000112394","H2QTK3,Uncharacterized protein","XP_001156832.1,monocarboxylate transporter 10 isoform X1","-","IPR036259,MFS transporter superfamily;IPR030762,Monocarboxylate transporter 10;IPR011701,Major facilitator superfamily;IPR020846,Major facilitator superfamily domain","COG0477,Permeases of the major facilitator superfamily;KOG2504,Monocarboxylate transporter","GO:0015718,biological_process,monocarboxylic acid transport;GO:0008028,molecular_function,monocarboxylic acid transmembrane transporter activity;GO:0015349,molecular_function,thyroid hormone transmembrane transporter activity;GO:0015173,molecular_function,aromatic amino acid transmembrane transporter activity;GO:0055085,biological_process,transmembrane transport;GO:0015801,biological_process,aromatic amino acid transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0070327,biological_process,thyroid hormone transport","K08187,ko04974,Protein digestion and absorption;K08187,ko04919,Thyroid hormone signaling pathway"]
["LEPROT",7.209502215,2.189845442,1.71606166,4.674854325,{"v":1.67E-7,"d":"1.67E-07"},{"v":9.33E-7,"d":"9.33E-07"},"ENSG00000213625","A0A087X0N2,Leptin receptor gene-related protein","NP_001185610.1,leptin receptor gene-related protein isoform 2","PF04133,Vacuolar protein sorting 55","IPR007262,Vacuolar protein sorting 55","ENOG4111UCZ,-;KOG2174,Leptin receptor gene-related protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["EEF2",1106.39799,337.0206083,1.71493628,11.50548933,{"v":4.57e-16,"d":"4.57E-16"},1.77E-14,"ENSG00000167658","G3RAS9,Uncharacterized protein","XP_004059791.1,-","PF00009,longation factor Tu GTP binding domain;PF00679,longation factor G C-terminus;PF03144,longation factor Tu domain 2;PF14492,longation Factor G, domain II;PF03764,longation factor G, domain IV","IPR035647,EF-G domain III/V-like;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004161,Translation elongation factor EFTu-like, domain 2;IPR005517,Translation elongation factor EFG/EF2, domain IV;IPR000795,Transcription factor, GTP-binding domain;IPR009000,Translation protein, beta-barrel domain superfamily;IPR020568,Ribosomal protein S5 domain 2-type fold;IPR031157,Tr-type G domain, conserved site;IPR000640,Elongation factor EFG, domain V-like;IPR014721,Ribosomal protein S5 domain 2-type fold, subgroup","-","GO:0019901,molecular_function,protein kinase binding;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0005525,molecular_function,GTP binding;GO:0005844,cellular_component,polysome;GO:0030529,,;GO:0005737,cellular_component,cytoplasm;GO:0005886,cellular_component,plasma membrane;GO:0006414,biological_process,translational elongation;GO:0045296,molecular_function,cadherin binding;GO:0003924,molecular_function,GTPase activity;GO:0005829,cellular_component,cytosol;GO:0016235,cellular_component,aggresome;GO:0045727,biological_process,positive regulation of translation","K03234,ko04921,Oxytocin signaling pathway;K03234,ko04152,AMPK signaling pathway"]
["MYO6",17.51555767,5.333622384,1.714712597,6.663439341,{"v":2.24e-12,"d":"2.24E-12"},{"v":3.7e-11,"d":"3.70E-11"},"ENSG00000196586","E7EW20,Unconventional myosin-VI","-","PF16521,Myosin VI cargo binding domain;PF00063,Myosin head (motor domain)","IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036114,Class VI myosin, motor domain;IPR036961,Kinesin motor domain superfamily;IPR008989,Myosin S1 fragment, N-terminal;IPR032412,Myosin VI, cargo binding domain","KOG0163,Myosin class VI heavy chain;COG5022,Myosin heavy chain","GO:0016459,cellular_component,myosin complex;GO:0005524,molecular_function,ATP binding;GO:0007018,biological_process,microtubule-based movement;GO:0003779,molecular_function,actin binding;GO:0008017,molecular_function,microtubule binding;GO:0051015,molecular_function,actin filament binding;GO:0003774,molecular_function,motor activity;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity","-"]
["LA16c-366D1.3",54.37637781,16.52084597,1.714308872,4.151470702,{"v":4.25E-6,"d":"4.25E-06"},{"v":1.76e-05,"d":"1.76E-05"},"ENSG00000261691","A0A1B0GVE3,Calpain-15","-","PF00641,Zn-finger in Ran binding protein and others","IPR001876,Zinc finger, RanBP2-type;IPR036443,Zinc finger, RanBP2-type superfamily","-","GO:0046872,molecular_function,metal ion binding","-"]
["TPCN1",3.210391515,0.976082673,1.713627944,4.261136256,{"v":1.74e-06,"d":"1.74E-06"},{"v":7.83e-06,"d":"7.83E-06"},"ENSG00000186815","G3R4J8,Two pore segment channel 1","XP_004053985.1,two pore calcium channel protein 1 isoform X1","PF00520,Ion transport protein","IPR005821,Ion transport domain;IPR027359,Voltage-dependent channel domain superfamily;IPR028801,Two pore calcium channel protein 1","-","GO:0005216,molecular_function,ion channel activity;GO:0055085,biological_process,transmembrane transport;GO:0034220,biological_process,ion transmembrane transport;GO:0005765,cellular_component,lysosomal membrane;GO:0005245,molecular_function,voltage-gated calcium channel activity;GO:0006811,biological_process,ion transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0010008,cellular_component,endosome membrane;GO:0072345,molecular_function,NAADP-sensitive calcium-release channel activity;GO:0042802,molecular_function,identical protein binding;GO:0051209,biological_process,release of sequestered calcium ion into cytosol;GO:0010508,biological_process,positive regulation of autophagy;GO:0070588,biological_process,calcium ion transmembrane transport","-"]
["HSD17B4",19.32915774,5.891652275,1.713323035,6.71147426,{"v":1.88e-12,"d":"1.88E-12"},{"v":3.2e-11,"d":"3.20E-11"},"ENSG00000133835","G3QHZ6,Hydroxysteroid 17-beta dehydrogenase 4","XP_004042441.2,peroxisomal multifunctional enzyme type 2 isoform X3","PF08659,KR domain;PF00106,short chain dehydrogenase;PF01575,MaoC like domain;PF02036,SCP-2 sterol transfer family;PF13452,N-terminal half of MaoC dehydratase;PF13561,noyl-(Acyl carrier protein) reductase","IPR002539,MaoC-like domain;IPR020904,Short-chain dehydrogenase/reductase, conserved site;IPR036291,NAD(P)-binding domain superfamily;IPR003033,SCP2 sterol-binding domain;IPR002347,Short-chain dehydrogenase/reductase SDR;IPR036527,SCP2 sterol-binding domain superfamily;IPR029069,HotDog domain superfamily","-","GO:0044594,molecular_function,17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0060009,biological_process,Sertoli cell development;GO:0008209,biological_process,androgen metabolic process;GO:0042803,molecular_function,protein homodimerization activity;GO:0016508,molecular_function,long-chain-enoyl-CoA hydratase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0006635,biological_process,fatty acid beta-oxidation;GO:0005102,molecular_function,signaling receptor binding;GO:0000038,biological_process,very long-chain fatty acid metabolic process;GO:0036112,biological_process,medium-chain fatty-acyl-CoA metabolic process;GO:0005739,cellular_component,mitochondrion;GO:0008210,biological_process,estrogen metabolic process;GO:0036111,biological_process,very long-chain fatty-acyl-CoA metabolic process;GO:0005777,cellular_component,peroxisome;GO:0003857,molecular_function,3-hydroxyacyl-CoA dehydrogenase activity","K12405,ko04146,Peroxisome;K12405,ko00120,Primary bile acid biosynthesis"]
["RAB38",5.186842764,1.565627383,1.713146589,2.512871406,0.005463975,0.011102495,"ENSG00000123892","H2Q4I8,RAB38, member RAS oncogene family","XP_508683.2,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR030697,Ras-related protein Rab29/Rab38/Rab32;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG4423,GTP-binding protein-like, RAS superfamily;ENOG410YITC,-","GO:0005525,molecular_function,GTP binding;GO:0007005,biological_process,mitochondrion organization;GO:0033162,cellular_component,melanosome membrane;GO:0005802,cellular_component,trans-Golgi network;GO:0005769,cellular_component,early endosome;GO:0036461,molecular_function,BLOC-2 complex binding;GO:0090383,biological_process,phagosome acidification;GO:0072657,biological_process,protein localization to membrane;GO:0005794,cellular_component,Golgi apparatus;GO:0035651,molecular_function,AP-3 adaptor complex binding;GO:1903232,biological_process,melanosome assembly;GO:0042470,cellular_component,melanosome;GO:0005739,cellular_component,mitochondrion;GO:0003924,molecular_function,GTPase activity;GO:0045335,cellular_component,phagocytic vesicle;GO:0030742,molecular_function,GTP-dependent protein binding;GO:0035646,biological_process,endosome to melanosome transport;GO:0016020,cellular_component,membrane;GO:0031982,cellular_component,vesicle;GO:0035650,molecular_function,AP-1 adaptor complex binding;GO:0005764,cellular_component,lysosome;GO:0016192,biological_process,vesicle-mediated transport;GO:0044233,cellular_component,ER-mitochondrion membrane contact site","-"]
["AC005037.3",7.809583401,2.357290972,1.713146589,2.512871406,0.005463975,0.011102495,"ENSG00000183308","G7PXF9,Uncharacterized protein","-","-","-","-","-","-"]
["ZSCAN21",3.550805911,1.071796316,1.713146589,2.512871406,0.005463975,0.011102495,"ENSG00000166529","K7CI01,Zinc finger and SCAN domain containing 21","NP_001129089.1,zinc finger and SCAN domain-containing protein 21;XP_009451518.1,-;XP_009451517.1,-;XP_009451515.1,-","PF00096,Zinc finger, C2H2 type;PF02023,SCAN domain","IPR003309,SCAN domain;IPR013087,Zinc finger C2H2-type;IPR038269,SCAN domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006351,biological_process,transcription, DNA-templated;GO:0046872,molecular_function,metal ion binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["ITFG1",3.88126621,1.180769171,1.713043672,4.362997272,{"v":1.23e-06,"d":"1.23E-06"},{"v":5.7e-06,"d":"5.70E-06"},"ENSG00000129636","H2QB19,Integrin alpha FG-GAP repeat containing 1","XP_520622.2,T-cell immunomodulatory protein","PF13517,Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella","IPR024881,T-cell immunomodulatory protein","ENOG410XPFB,-;KOG4550,Predicted membrane protein","GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TRAPPC9",4.274619199,1.300436068,1.713043672,4.362997272,{"v":1.23e-06,"d":"1.23E-06"},{"v":5.7e-06,"d":"5.70E-06"},"ENSG00000167632","H2QWR8,Uncharacterized protein","XP_001142596.2,trafficking protein particle complex subunit 9 isoform X2","PF08626,Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit","IPR013935,TRAPP II complex, Trs120","KOG1953,Targeting complex (TRAPP) subunit;ENOG410YEPC,-","GO:0021987,biological_process,cerebral cortex development;GO:0005737,cellular_component,cytoplasm;GO:0005802,cellular_component,trans-Golgi network;GO:0030008,cellular_component,TRAPP complex;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity;GO:0030182,biological_process,neuron differentiation","-"]
["CHSY1",6.198329625,1.887530197,1.712093007,4.547275971,{"v":3.14e-07,"d":"3.14E-07"},{"v":1.64E-6,"d":"1.64E-06"},"ENSG00000131873","G3R0R0,Hexosyltransferase","XP_004056885.1,chondroitin sulfate synthase 1","PF05679,Chondroitin N-acetylgalactosaminyltransferase","IPR008428,Chondroitin N-acetylgalactosaminyltransferase;IPR029044,Nucleotide-diphospho-sugar transferases","-","GO:0002063,biological_process,chondrocyte development;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0030279,biological_process,negative regulation of ossification;GO:0032580,cellular_component,Golgi cisterna membrane;GO:0008376,molecular_function,acetylgalactosaminyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0009954,biological_process,proximal/distal pattern formation;GO:0045880,biological_process,positive regulation of smoothened signaling pathway;GO:0030206,biological_process,chondroitin sulfate biosynthetic process;GO:0047238,molecular_function,glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0051923,biological_process,sulfation;GO:0060349,biological_process,bone morphogenesis;GO:0005794,cellular_component,Golgi apparatus;GO:0051216,biological_process,cartilage development;GO:0005576,cellular_component,extracellular region","K13499,ko00532,Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate"]
["PPFIA3",1.509202598,0.457133934,1.711447599,2.834423942,0.00122165,0.002897996,"ENSG00000177380","A0A0D9S351,PTPRF interacting protein alpha 3","XP_007995697.1,liprin-alpha-3 isoform X1","PF00536,SAM domain (Sterile alpha motif);PF07647,SAM domain (Sterile alpha motif)","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR029515,LAR-interacting protein, Liprin;IPR037622,Liprin-alpha, SAM domain repeat 3;IPR001660,Sterile alpha motif domain;IPR030440,Liprin-alpha-3;IPR037621,Liprin-alpha, SAM domain repeat 2;IPR037620,Liprin-alpha, SAM domain repeat 1","-","GO:0001669,cellular_component,acrosomal vesicle;GO:0007269,biological_process,neurotransmitter secretion;GO:0048786,cellular_component,presynaptic active zone","-"]
["XRCC4",4.436848753,1.346897569,1.710359529,3.096251458,0.000793692,0.001959933,"ENSG00000152422","A0A024RAQ8,X-ray repair complementing defective repair in Chinese hamster cells 4, isoform CRA_b","XP_011541928.1,-;NP_071801.1,DNA repair protein XRCC4 isoform 2;NP_001304941.1,-","PF06632,NA double-strand break repair and V(D)J recombination protein XRCC4","IPR010585,DNA repair protein XRCC4;IPR009089,XRCC4, N-terminal domain superfamily","ENOG410Y7Z3,-;ENOG410IJSN,-","GO:0003677,molecular_function,DNA binding;GO:0071285,biological_process,cellular response to lithium ion;GO:0006302,biological_process,double-strand break repair;GO:0005634,cellular_component,nucleus;GO:0006310,biological_process,DNA recombination;GO:0005654,cellular_component,nucleoplasm","K10886,ko03450,Non-homologous end-joining"]
["AKR7A2",7.86645063,2.391703979,1.709603082,3.317183844,2.16832E-4,6.08666E-4,"ENSG00000053371","V9HWA2,Aldo-keto reductase family 7, member A2","NP_003680.2,aflatoxin B1 aldehyde reductase member 2 isoform 1","PF00248,Aldo/keto reductase family","IPR036812,NADP-dependent oxidoreductase domain superfamily;IPR023210,NADP-dependent oxidoreductase domain","ENOG410IDYD,-;COG0667,Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)","GO:0005829,cellular_component,cytosol","K15303,ko00980,Metabolism of xenobiotics by cytochrome P450"]
["ONECUT3",1.684316972,0.512097233,1.709603082,3.317183844,2.16832E-4,6.08666E-4,"ENSG00000205922","A0A0D9RHQ5,One cut domain family member","-","PF02376,CUT domain;PF00046,Homeobox domain","IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR003350,CUT domain;IPR010982,Lambda repressor-like, DNA-binding domain superfamily","-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["DCLRE1A",3.974876345,1.210930123,1.70862028,3.676835162,{"v":3.72e-05,"d":"3.72E-05"},0.000124366,"ENSG00000198924","H2R4B0,DNA cross-link repair 1A","XP_009457548.1,DNA cross-link repair 1A protein","PF07522,NA repair metallo-beta-lactamase","IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR011084,DNA repair metallo-beta-lactamase","KOG1361,Predicted hydrolase involved in interstrand cross-link repair;COG1236,Predicted exonuclease of the beta-lactamase fold involved in RNA processing","GO:0035312,molecular_function,5'-3' exodeoxyribonuclease activity;GO:0031848,biological_process,protection from non-homologous end joining at telomere;GO:0003684,molecular_function,damaged DNA binding;GO:0000784,cellular_component,nuclear chromosome, telomeric region;GO:0001650,cellular_component,fibrillar center;GO:0006303,biological_process,double-strand break repair via nonhomologous end joining;GO:0036297,biological_process,interstrand cross-link repair;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0005654,cellular_component,nucleoplasm","-"]
["NMNAT2",2.850184577,0.868891201,1.708283051,3.827501924,{"v":2.9E-5,"d":"2.90E-05"},{"v":9.92e-05,"d":"9.92E-05"},"ENSG00000157064","G3R7X1,Nicotinamide nucleotide adenylyltransferase 2","-","PF01467,Cytidylyltransferase-like","IPR004821,Cytidyltransferase-like domain","-","GO:0005794,cellular_component,Golgi apparatus;GO:0005770,cellular_component,late endosome;GO:0003824,molecular_function,catalytic activity;GO:0005802,cellular_component,trans-Golgi network;GO:0009058,biological_process,biosynthetic process;GO:0004515,molecular_function,nicotinate-nucleotide adenylyltransferase activity;GO:0045202,cellular_component,synapse","K06210,ko00760,Nicotinate and nicotinamide metabolism"]
["TESK1",6.192108094,1.887691163,1.708283051,3.827501924,{"v":2.9E-5,"d":"2.90E-05"},{"v":9.92e-05,"d":"9.92E-05"},"ENSG00000107140","H2QX81,Testis-specific kinase 1","-","PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR015782,Dual specificity testis-specific protein kinase 1;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;ENOG410IF1S,-","GO:0016301,molecular_function,kinase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0004871,molecular_function,signal transducer activity;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0046872,molecular_function,metal ion binding;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["POLQ",2.627218629,0.801729706,1.707783594,4.088167813,{"v":6.75e-06,"d":"6.75E-06"},{"v":2.67e-05,"d":"2.67E-05"},"ENSG00000051341","A0A087WXL3,DNA polymerase theta","-","PF00271,Helicase conserved C-terminal domain;PF00476,NA polymerase family A;PF00270,AD/DEAH box helicase","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR011545,DEAD/DEAH box helicase domain;IPR002298,DNA polymerase A;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR019760,DNA-directed DNA polymerase, family A, conserved site;IPR036397,Ribonuclease H superfamily;IPR001098,DNA-directed DNA polymerase, family A, palm domain;IPR012337,Ribonuclease H-like superfamily;IPR001650,Helicase, C-terminal","COG1204,Superfamily II helicase;COG0749,DNA polymerase I - 3'-5' exonuclease and polymerase domains;KOG0950,DNA polymerase theta/eta, DEAD-box superfamily","GO:0003887,molecular_function,DNA-directed DNA polymerase activity;GO:0003677,molecular_function,DNA binding;GO:0071897,biological_process,DNA biosynthetic process;GO:0003676,molecular_function,nucleic acid binding;GO:0006260,biological_process,DNA replication;GO:0006261,biological_process,DNA-dependent DNA replication;GO:0005524,molecular_function,ATP binding","-"]
["HPS3",4.63077649,1.4141485,1.707431446,4.308565482,{"v":1.43e-06,"d":"1.43E-06"},{"v":6.57e-06,"d":"6.57E-06"},"ENSG00000163755","H2QNJ8,Hermansky-Pudlak syndrome 3","XP_001139589.1,Hermansky-Pudlak syndrome 3 protein isoform X1","PF14763,Hermansky-Pudlak syndrome 3, C-terminal;PF14761,Hermansky-Pudlak syndrome 3;PF14762,Hermansky-Pudlak syndrome 3, middle region","IPR017216,Hermansky-Pudlak syndrome 3 protein;IPR028167,Hermansky-Pudlak syndrome 3, central region;IPR029437,Hermansky-Pudlak syndrome 3 protein, N-terminal domain;IPR029438,Hermansky-Pudlak syndrome 3 protein, C-terminal domain","ENOG410XQDA,-;ENOG410IGMD,-","GO:0005737,cellular_component,cytoplasm;GO:0006996,biological_process,organelle organization;GO:0043473,biological_process,pigmentation;GO:0031084,cellular_component,BLOC-2 complex","-"]
["ERMAP",8.101641752,2.47640263,1.70696777,4.668020887,{"v":2.05E-7,"d":"2.05E-07"},{"v":1.12e-06,"d":"1.12E-06"},"ENSG00000164010","A0A1C9HIH9,Erythroblast membrane-associated protein","XP_011538872.1,-;NP_001017922.1,-;NP_061008.2,erythroid membrane-associated protein precursor;XP_006710376.1,-","-","IPR007110,Immunoglobulin-like domain;IPR036179,Immunoglobulin-like domain superfamily;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR003877,SPRY domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR013106,Immunoglobulin V-set domain;IPR006574,SPRY-associated","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MYO19",3.52330923,1.077592974,1.706676128,4.955236331,{"v":4.23e-08,"d":"4.23E-08"},{"v":2.7e-07,"d":"2.70E-07"},"ENSG00000278259","B4E218,cDNA FLJ61052, highly similar to Homo sapiens myosin head domain containing 1","NP_079385.2,unconventional myosin-XIX isoform 1;NP_001157207.1,unconventional myosin-XIX isoform 2","PF00063,Myosin head (motor domain)","IPR036961,Kinesin motor domain superfamily;IPR036035,Class XIX myosin, motor domain;IPR000048,IQ motif, EF-hand binding site;IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0160,Myosin class V heavy chain;COG5022,Myosin heavy chain","GO:0003777,molecular_function,microtubule motor activity;GO:0016459,cellular_component,myosin complex;GO:0003779,molecular_function,actin binding;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0003774,molecular_function,motor activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0005739,cellular_component,mitochondrion","-"]
["INO80",10.52895711,3.22337863,1.706194501,5.620628498,{"v":7.95e-10,"d":"7.95E-10"},{"v":7.46e-09,"d":"7.46E-09"},"ENSG00000128908","A0A024R9R7,INO80 complex homolog 1","NP_060023.1,DNA helicase INO80","PF00271,Helicase conserved C-terminal domain;PF00176,SNF2 family N-terminal domain;PF13892,NA-binding domain","IPR038718,SNF2-like, N-terminal domain superfamily;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR020838,DBINO domain;IPR001650,Helicase, C-terminal;IPR000330,SNF2-related, N-terminal domain;IPR031047,DNA helicase Ino80","KOG0388,SNF2 family DNA-dependent ATPase;ENOG410XP0A,-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0006338,biological_process,chromatin remodeling;GO:0045111,cellular_component,intermediate filament cytoskeleton;GO:0016887,molecular_function,ATPase activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0006281,biological_process,DNA repair;GO:0031011,cellular_component,Ino80 complex;GO:0016604,cellular_component,nuclear body;GO:0005524,molecular_function,ATP binding;GO:0005886,cellular_component,plasma membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["RNF216",11.37589618,3.483493772,1.706076337,5.847655636,{"v":2.04e-10,"d":"2.04E-10"},{"v":2.17e-09,"d":"2.17E-09"},"ENSG00000011275","H2QU50,Ring finger protein 216","XP_518955.2,E3 ubiquitin-protein ligase RNF216 isoform X1","-","IPR002867,IBR domain;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG1812,Predicted E3 ubiquitin ligase;ENOG410XS1H,-","-","-"]
["ST14",24.83778531,7.60781792,1.705941716,6.161034238,{"v":3.97e-11,"d":"3.97E-11"},{"v":4.96e-10,"d":"4.96E-10"},"ENSG00000149418","B2RAF9,Suppressor of tumorigenicity 14 protein homolog","-","PF01390,SEA domain;PF00089,Trypsin;PF00431,CUB domain;PF00057,Low-density lipoprotein receptor domain class A","IPR017051,Peptidase S1A, matripase;IPR035914,Spermadhesin, CUB domain superfamily;IPR018114,Serine proteases, trypsin family, histidine active site;IPR001254,Serine proteases, trypsin domain;IPR033116,Serine proteases, trypsin family, serine active site;IPR036364,SEA domain superfamily;IPR009003,Peptidase S1, PA clan;IPR000082,SEA domain;IPR000859,CUB domain;IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR036055,LDL receptor-like superfamily","KOG3627,Trypsin;COG5640,Secreted trypsin-like serine protease","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0008236,molecular_function,serine-type peptidase activity;GO:0008233,molecular_function,peptidase activity","-"]
["WDR26",12.75546816,3.907826604,1.705836978,6.464663284,7.91E-12,1.16E-10,"ENSG00000162923","I3NDX3,WD repeat domain 26","-","PF00400,WD domain, G-beta repeat","IPR017986,WD40-repeat-containing domain;IPR006594,LIS1 homology motif;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR006595,CTLH, C-terminal LisH motif;IPR001680,WD40 repeat","KOG0293,WD40 repeat-containing protein;ENOG410XQ2U,-","GO:0005737,cellular_component,cytoplasm;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm","-"]
["PPP1R13L",20.15013554,6.186014961,1.702602575,6.071401112,{"v":5.43e-11,"d":"5.43E-11"},{"v":6.55e-10,"d":"6.55E-10"},"ENSG00000104881","A0A024R0Q5,Protein phosphatase 1, regulatory","NP_001135974.1,-;NP_006654.2,relA-associated inhibitor;XP_016881666.1,-;XP_016881667.1,-","PF12796,Ankyrin repeats (3 copies);PF14604,Variant SH3 domain","IPR002110,Ankyrin repeat;IPR020683,Ankyrin repeat-containing domain;IPR036028,SH3-like domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR028320,RelA-associated inhibitor;IPR001452,SH3 domain","KOG0515,p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains;ENOG410Y17W,-","GO:0003229,biological_process,ventricular cardiac muscle tissue development;GO:0048871,biological_process,multicellular organismal homeostasis;GO:0045171,cellular_component,intercellular bridge;GO:0006915,biological_process,apoptotic process;GO:0003215,biological_process,cardiac right ventricle morphogenesis;GO:0035264,biological_process,multicellular organism growth;GO:0042633,biological_process,hair cycle;GO:0060048,biological_process,cardiac muscle contraction;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0031076,biological_process,embryonic camera-type eye development;GO:0009791,biological_process,post-embryonic development;GO:0005829,cellular_component,cytosol;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0030054,cellular_component,cell junction;GO:0045597,biological_process,positive regulation of cell differentiation","-"]
["THUMPD1",14.61068422,4.48577859,1.702414304,5.978556862,{"v":9.17e-11,"d":"9.17E-11"},{"v":1.06e-09,"d":"1.06E-09"},"ENSG00000066654","Q6MZT3,Uncharacterized protein DKFZp686C1054","NP_060206.2,THUMP domain-containing protein 1;NP_001291479.1,-","PF02926,THUMP domain","IPR004114,THUMP domain","COG1818,Predicted RNA-binding protein, contains THUMP domain;KOG3943,THUMP domain-containing proteins","GO:0003723,molecular_function,RNA binding","-"]
["BAIAP2L1",26.67591044,8.195000711,1.701847079,6.403418217,{"v":1.1e-11,"d":"1.10E-11"},1.57E-10,"ENSG00000006453","H2R0D5,BAI1-associated protein 2-like 1","XP_016800548.1,-;XP_519222.3,brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X1","PF14604,Variant SH3 domain;PF08397,IRSp53/MIM homology domain","IPR030060,I-BAR domain containing protein IRTKS;IPR027267,AH/BAR domain superfamily;IPR035592,IRTKS, SH3 domain;IPR013606,IMD/I-BAR domain;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain;IPR027681,I-BAR domain containing protein IRSp53/IRTKS/Pinkbar","ENOG410Y6FF,-;ENOG410IGQC,-","GO:0051764,biological_process,actin crosslink formation;GO:0030838,biological_process,positive regulation of actin filament polymerization;GO:0008286,biological_process,insulin receptor signaling pathway;GO:0015629,cellular_component,actin cytoskeleton;GO:0030833,biological_process,regulation of actin filament polymerization;GO:0046626,biological_process,regulation of insulin receptor signaling pathway;GO:2000251,biological_process,positive regulation of actin cytoskeleton reorganization;GO:0007009,biological_process,plasma membrane organization;GO:0051017,biological_process,actin filament bundle assembly;GO:0005829,cellular_component,cytosol","-"]
["SLC35A4",16.17302506,4.968299814,1.701046102,5.442617192,{"v":1.92E-9,"d":"1.92E-09"},{"v":1.66E-8,"d":"1.66E-08"},"ENSG00000176087","G3QNB1,Solute carrier family 35 member A4","-","PF04142,Nucleotide-sugar transporter","IPR027854,Short transmembrane mitochondrial protein 1","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["THAP12",7.867192596,2.417085074,1.700740939,5.346737752,{"v":3.41E-9,"d":"3.41E-09"},{"v":2.78e-08,"d":"2.78E-08"},"ENSG00000137492","K7DMS0,Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of","-","PF05485,THAP domain;PF05699,hAT family C-terminal dimerisation region;PF14291,omain of unknown function (DUF4371)","-","-","-","-"]
["ZNF143",5.048762834,1.548138177,1.700159599,3.891342681,{"v":1.73E-5,"d":"1.73E-05"},{"v":6.27e-05,"d":"6.27E-05"},"ENSG00000166478","K7B934,Zinc finger protein 143","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["HIVEP2",5.1262626,1.57562737,1.699750845,5.074701118,{"v":1.55E-8,"d":"1.55E-08"},{"v":1.1e-07,"d":"1.10E-07"},"ENSG00000010818","G3RQW1,Human immunodeficiency virus type I enhancer binding protein 2","XP_018885408.1,transcription factor HIVEP2","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0005654,cellular_component,nucleoplasm","-"]
["POLL",3.548758629,1.088181183,1.699580022,3.747603349,{"v":2.85e-05,"d":"2.85E-05"},{"v":9.78e-05,"d":"9.78E-05"},"ENSG00000166169","H2R0B4,Polymerase","XP_009457172.1,DNA polymerase lambda isoform X2;XP_009457173.1,-","PF10391,ingers domain of DNA polymerase lambda;PF14716,Helix-hairpin-helix domain;PF14792,NA polymerase beta palm;PF14791,NA polymerase beta thumb","IPR018944,DNA polymerase lambda, fingers domain;IPR037160,DNA polymerase, thumb domain superfamily;IPR001357,BRCT domain;IPR028207,DNA polymerase beta, palm domain;IPR010996,DNA polymerase beta-like, N-terminal domain;IPR022312,DNA polymerase family X;IPR019843,DNA polymerase family X, binding site;IPR036420,BRCT domain superfamily;IPR002054,DNA-directed DNA polymerase X;IPR029398,DNA polymerase beta, thumb domain;IPR002008,DNA polymerase family X, beta-like;IPR027421,DNA polymerase lambda lyase domain superfamily","COG1796,DNA polymerase IV (family X);KOG2534,DNA polymerase IV (family X)","GO:0006287,biological_process,base-excision repair, gap-filling;GO:0003887,molecular_function,DNA-directed DNA polymerase activity;GO:0034061,molecular_function,DNA polymerase activity;GO:0071897,biological_process,DNA biosynthetic process;GO:0051575,molecular_function,5'-deoxyribose-5-phosphate lyase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0006303,biological_process,double-strand break repair via nonhomologous end joining;GO:0006289,biological_process,nucleotide-excision repair;GO:0006281,biological_process,DNA repair;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0000724,biological_process,double-strand break repair via homologous recombination","-"]
["PPP2R2C",2.091136309,0.641220049,1.699580022,3.747603349,{"v":2.85e-05,"d":"2.85E-05"},{"v":9.78e-05,"d":"9.78E-05"},"ENSG00000074211","I3MIA7,Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B","XP_005319037.1,-","-","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR018067,Protein phosphatase 2A regulatory subunit PR55, conserved site;IPR000009,Protein phosphatase 2A regulatory subunit PR55","KOG1354,Serine/threonine protein phosphatase 2A, regulatory subunit;COG5170,Serine/threonine protein phosphatase 2A, regulatory subunit","GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0019888,molecular_function,protein phosphatase regulator activity;GO:0000159,cellular_component,protein phosphatase type 2A complex","-"]
["NGRN",23.23986085,7.15459563,1.699035174,6.88178377,{"v":1.53e-12,"d":"1.53E-12"},{"v":2.65e-11,"d":"2.65E-11"},"ENSG00000182768","G3RT32,Neugrin, neurite outgrowth associated","XP_004056806.1,neugrin","PF06413,Neugrin","IPR010487,Neugrin/Rrg9","-","-","-"]
["WDR72",1.994532252,0.611597658,1.698856169,3.587735879,{"v":8.66e-05,"d":"8.66E-05"},0.000264661,"ENSG00000166415","H0YKE0,WD repeat-containing protein 72","-","PF00400,WD domain, G-beta repeat","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR019775,WD40 repeat, conserved site;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","ENOG410ISIU,-;ENOG411264G,-","-","-"]
["VAMP7",24.75212613,7.617222945,1.698525147,5.463662982,{"v":1.78e-09,"d":"1.78E-09"},{"v":1.54e-08,"d":"1.54E-08"},"ENSG00000124333","K6ZLE4,Vesicle-associated membrane protein 7","XP_016800133.1,-","PF13774,Regulated-SNARE-like domain","IPR010908,Longin domain;IPR011012,Longin-like domain superfamily","-","GO:0006906,biological_process,vesicle fusion;GO:0030027,cellular_component,lamellipodium;GO:0031201,cellular_component,SNARE complex;GO:0031091,cellular_component,platelet alpha granule;GO:0005737,cellular_component,cytoplasm;GO:0005802,cellular_component,trans-Golgi network;GO:0043308,biological_process,eosinophil degranulation;GO:0031143,cellular_component,pseudopodium;GO:0043312,biological_process,neutrophil degranulation;GO:0030667,cellular_component,secretory granule membrane;GO:1903595,biological_process,positive regulation of histamine secretion by mast cell;GO:0005886,cellular_component,plasma membrane;GO:0043320,biological_process,natural killer cell degranulation;GO:0016020,cellular_component,membrane;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016192,biological_process,vesicle-mediated transport;GO:0030141,cellular_component,secretory granule;GO:0008333,biological_process,endosome to lysosome transport;GO:0035577,cellular_component,azurophil granule membrane","K08515,ko04130,SNARE interactions in vesicular transport"]
["TIGD7",3.564448214,1.092992192,1.697926509,3.407626143,0.000210713,0.000595019,"ENSG00000140993","H2QAG1,Tigger transposable element derived 7","XP_003952825.1,tigger transposable element-derived protein 7","PF03184,superfamily endonuclease;PF03221,Tc5 transposase DNA-binding domain;PF04218,CENP-B N-terminal DNA-binding domain","IPR006600,HTH CenpB-type DNA-binding domain;IPR009057,Homeobox-like domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR004875,DDE superfamily endonuclease domain;IPR007889,DNA binding HTH domain, Psq-type","ENOG4110CDI,-;KOG3105,DNA-binding centromere protein B (CENP-B)","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["GALNT2",25.27020014,7.786397248,1.697839584,7.01103383,{"v":7.74e-13,"d":"7.74E-13"},1.45E-11,"ENSG00000143641","A0A1L7NY50,Polypeptide N-acetylgalactosaminyltransferase","NP_004472.1,polypeptide N-acetylgalactosaminyltransferase 2 precursor","-","IPR035992,Ricin B-like lectins;IPR000772,Ricin B, lectin domain;IPR029044,Nucleotide-diphospho-sugar transferases;IPR001173,Glycosyltransferase 2-like","-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0006486,biological_process,protein glycosylation;GO:0016740,molecular_function,transferase activity;GO:0030246,molecular_function,carbohydrate binding;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0005794,cellular_component,Golgi apparatus;GO:0016021,cellular_component,integral component of membrane","K00710,ko00512,Mucin type O-Glycan biosynthesis"]
["YRDC",7.022370123,2.153319464,1.696688721,3.201345335,0.000410333,1.084673E-3,"ENSG00000196449","K7B8P6,YrdC domain containing","-","PF01300,Telomere recombination","IPR017945,DHBP synthase RibB-like alpha/beta domain superfamily;IPR006070,YrdC-like domain","COG0009,Putative translation factor (SUA5);KOG3051,RNA binding/translational regulation protein of the SUA5 family","GO:0003725,molecular_function,double-stranded RNA binding","-"]
["MESDC1",2.646614622,0.811550328,1.696688721,3.201345335,0.000410333,1.084673E-3,"ENSG00000140406","H2Q9Y2,Mesoderm development candidate 1","XP_003314880.1,mesoderm development candidate 1","-","-","KOG4261,Talin;ENOG410XQ0V,-","-","-"]
["EPB41L4A",11.75956208,3.627129723,1.69583165,6.066265037,{"v":6.05e-11,"d":"6.05E-11"},{"v":7.24e-10,"d":"7.24E-10"},"ENSG00000129595","H2QRB4,Erythrocyte membrane protein band 4.1 like 4A","XP_001143134.1,band 4.1-like protein 4A isoform X2","PF09379,RM N-terminal domain;PF00373,RM central domain;PF08736,RM adjacent (FA);PF09380,RM C-terminal PH-like domain","IPR019748,FERM central domain;IPR014847,FERM adjacent (FA);IPR030696,Band 4.1-like protein 4A;IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR019747,FERM conserved site;IPR011993,PH-like domain superfamily;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR000798,Ezrin/radixin/moesin-like;IPR029071,Ubiquitin-like domain superfamily","ENOG410IQ5Z,-;ENOG410XRF6,-","GO:0005856,cellular_component,cytoskeleton;GO:0031032,biological_process,actomyosin structure organization;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0005200,molecular_function,structural constituent of cytoskeleton","-"]
["LHFPL2",3.601940276,1.109052654,1.695571495,4.299710595,{"v":1.43e-06,"d":"1.43E-06"},{"v":6.57e-06,"d":"6.57E-06"},"ENSG00000145685","H2QR50,Lipoma HMGIC fusion partner-like 2","XP_009447250.1,-;XP_003310737.1,-","PF10242,Lipoma HMGIC fusion partner-like protein","IPR019372,Lipoma HMGIC fusion partner-like protein","KOG4026,Uncharacterized conserved protein;ENOG410XSUB,-","GO:0046546,biological_process,development of primary male sexual characteristics;GO:0046545,biological_process,development of primary female sexual characteristics;GO:1905516,biological_process,positive regulation of fertilization;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TSEN2",1.885602001,0.578195597,1.694959188,2.959894243,0.001570614,0.003633681,"ENSG00000154743","A0A024R2H2,tRNA-splicing endonuclease subunit Sen2","NP_001308206.1,-;NP_001138864.1,-;NP_079541.1,tRNA-splicing endonuclease subunit Sen2 isoform 1;XP_016862785.1,-","PF01974,tRNA intron endonuclease, catalytic C-terminal domain;PF02778,tRNA intron endonuclease, N-terminal domain","IPR011856,tRNA endonuclease-like domain superfamily;IPR006676,tRNA-splicing endonuclease;IPR006678,tRNA intron endonuclease, N-terminal;IPR016589,tRNA-splicing endonuclease, SEN2 subunit;IPR006677,tRNA intron endonuclease, catalytic domain-like;IPR036167,tRNA intron endonuclease, catalytic domain-like superfamily","COG1676,tRNA splicing endonuclease;KOG4685,tRNA splicing endonuclease SEN2","GO:0006388,biological_process,tRNA splicing, via endonucleolytic cleavage and ligation;GO:0003676,molecular_function,nucleic acid binding;GO:0016829,molecular_function,lyase activity;GO:0000213,molecular_function,tRNA-intron endonuclease activity;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0004518,molecular_function,nuclease activity;GO:0005813,cellular_component,centrosome;GO:0004519,molecular_function,endonuclease activity;GO:0005829,cellular_component,cytosol;GO:0000214,cellular_component,tRNA-intron endonuclease complex;GO:0008033,biological_process,tRNA processing;GO:0090501,biological_process,RNA phosphodiester bond hydrolysis;GO:0005634,cellular_component,nucleus;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0005654,cellular_component,nucleoplasm","-"]
["NEIL3",8.988014962,2.768363003,1.694785965,4.193058497,{"v":3.43e-06,"d":"3.43E-06"},{"v":1.45E-5,"d":"1.45E-05"},"ENSG00000109674","G3RKV9,Nei like DNA glycosylase 3","XP_004040711.1,endonuclease 8-like 3","PF06831,ormamidopyrimidine-DNA glycosylase H2TH domain;PF06839,RF zinc finger","IPR015887,DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site;IPR012319,Formamidopyrimidine-DNA glycosylase, catalytic domain;IPR000214,Zinc finger, DNA glycosylase/AP lyase-type;IPR010979,Ribosomal protein S13-like, H2TH;IPR035937,MutM-like, N-terminal;IPR015886,DNA glycosylase/AP lyase, H2TH DNA-binding;IPR010666,Zinc finger, GRF-type;IPR036443,Zinc finger, RanBP2-type superfamily;IPR001876,Zinc finger, RanBP2-type","-","GO:0003697,molecular_function,single-stranded DNA binding;GO:0046872,molecular_function,metal ion binding;GO:0003906,molecular_function,DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0016799,molecular_function,hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0003690,molecular_function,double-stranded DNA binding;GO:0006284,biological_process,base-excision repair;GO:0003684,molecular_function,damaged DNA binding;GO:0006289,biological_process,nucleotide-excision repair;GO:0000405,molecular_function,bubble DNA binding;GO:0006281,biological_process,DNA repair;GO:0019104,molecular_function,DNA N-glycosylase activity;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","K10569,ko03410,Base excision repair"]
["CYB5R3",12.4435,3.840020284,1.694711053,5.632293893,{"v":8.49e-10,"d":"8.49E-10"},{"v":7.93e-09,"d":"7.93E-09"},"ENSG00000100243","K7D4S0,NADH-cytochrome b5 reductase","-","PF00175,Oxidoreductase NAD-binding domain;PF00970,Oxidoreductase FAD-binding domain","IPR001709,Flavoprotein pyridine nucleotide cytochrome reductase;IPR017938,Riboflavin synthase-like beta-barrel;IPR017927,Ferredoxin reductase-type FAD-binding domain;IPR001834,NADH:cytochrome b5 reductase (CBR);IPR001433,Oxidoreductase FAD/NAD(P)-binding;IPR008333,Oxidoreductase, FAD-binding domain","KOG0534,NADH-cytochrome b-5 reductase;COG0543,2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases","GO:0005783,cellular_component,endoplasmic reticulum;GO:0016491,molecular_function,oxidoreductase activity;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0004128,molecular_function,cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0055114,biological_process,oxidation-reduction process;GO:0005811,cellular_component,lipid droplet","-"]
["MAP3K1",7.016707248,2.165738167,1.693883693,5.18500306,{"v":1.07E-8,"d":"1.07E-08"},{"v":7.88e-08,"d":"7.88E-08"},"ENSG00000095015","H2R5K3,Uncharacterized protein","XP_003310777.1,mitogen-activated protein kinase kinase kinase 1 isoform X1","PF00069,Protein kinase domain","IPR001841,Zinc finger, RING-type;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR007527,Zinc finger, SWIM-type;IPR000719,Protein kinase domain","KOG4279,Serine/threonine protein kinase;ENOG410XQGS,-","GO:0007346,biological_process,regulation of mitotic cell cycle;GO:0019901,molecular_function,protein kinase binding;GO:0031098,biological_process,stress-activated protein kinase signaling cascade;GO:0023014,biological_process,signal transduction by protein phosphorylation;GO:0042981,biological_process,regulation of apoptotic process;GO:0032147,biological_process,activation of protein kinase activity;GO:0071260,biological_process,cellular response to mechanical stimulus;GO:0005737,cellular_component,cytoplasm;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0008270,molecular_function,zinc ion binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","K04416,ko04120,Ubiquitin mediated proteolysis;K04416,ko05166,HTLV-I infection;K04416,ko04010,MAPK signaling pathway;K04416,ko04622,RIG-I-like receptor signaling pathway;K04416,ko04722,Neurotrophin signaling pathway;K04416,ko04912,GnRH signaling pathway;K04416,ko05161,Hepatitis B"]
["EREG",11.87923763,3.668088243,1.693706951,5.504854558,{"v":1.87E-9,"d":"1.87E-09"},{"v":1.62e-08,"d":"1.62E-08"},"ENSG00000124882","H2PDL6,Epiregulin","XP_002814919.1,proepiregulin","-","IPR013032,EGF-like, conserved site;IPR015497,Epidermal growth factor receptor ligand;IPR000742,EGF-like domain","ENOG410YNFA,-;ENOG410IXV0,-","GO:0008285,biological_process,negative regulation of cell proliferation;GO:0042327,biological_process,positive regulation of phosphorylation;GO:0005615,cellular_component,extracellular space;GO:0007267,biological_process,cell-cell signaling;GO:0048146,biological_process,positive regulation of fibroblast proliferation;GO:0051151,biological_process,negative regulation of smooth muscle cell differentiation;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:0009299,biological_process,mRNA transcription;GO:0016021,cellular_component,integral component of membrane;GO:0005154,molecular_function,epidermal growth factor receptor binding;GO:0045860,biological_process,positive regulation of protein kinase activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0001819,biological_process,positive regulation of cytokine production;GO:0016020,cellular_component,membrane;GO:0045410,biological_process,positive regulation of interleukin-6 biosynthetic process;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0045089,biological_process,positive regulation of innate immune response;GO:0045840,biological_process,positive regulation of mitotic nuclear division;GO:0045740,biological_process,positive regulation of DNA replication;GO:0042108,biological_process,positive regulation of cytokine biosynthetic process;GO:0043616,biological_process,keratinocyte proliferation","K09784,ko04012,ErbB signaling pathway"]
["EIF4G1",134.7342595,41.66726624,1.693030692,9.510359089,2.79E-15,9.13E-14,"ENSG00000114867","B2RU10,eIF4G1 protein","NP_001181876.1,-;NP_001181875.1,eukaryotic translation initiation factor 4 gamma 1 isoform 6","PF02020,eIF4-gamma/eIF5/eIF2-epsilon;PF02854,MIF4G domain;PF02847,MA3 domain","IPR003307,W2 domain;IPR037584,Eukaryotic translation initiation factor 4 gamma 1;IPR003890,MIF4G-like, type 3;IPR016024,Armadillo-type fold;IPR016021,MIF4G-like domain superfamily;IPR003891,Initiation factor eIF-4 gamma, MA3","KOG0401,Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G);ENOG410XS4P,-","GO:0006413,biological_process,translational initiation;GO:0003743,molecular_function,translation initiation factor activity;GO:0008190,molecular_function,eukaryotic initiation factor 4E binding;GO:0003723,molecular_function,RNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003729,molecular_function,mRNA binding","-"]
["SCAMP1-AS1",4.770404704,1.462783237,1.69237223,2.668630448,3.609386E-3,7.670123E-3,"ENSG00000245556","G7PXF9,Uncharacterized protein","-","-","-","-","-","-"]
["C5orf22",11.44043365,3.534241378,1.692345392,5.008141148,{"v":3.31e-08,"d":"3.31E-08"},{"v":2.17E-7,"d":"2.17E-07"},"ENSG00000082213","A0A024RE14,Uncharacterized protein","NP_060826.2,UPF0489 protein C5orf22","PF12640,UPF0489 domain","IPR024131,Uncharacterised protein family UPF0489","ENOG41109E9,-;ENOG410IGS7,-","-","-"]
["PLCB3",31.14152993,9.637160149,1.69144338,6.675388068,{"v":4.55e-12,"d":"4.55E-12"},{"v":7.04e-11,"d":"7.04E-11"},"ENSG00000149782","G3S3I2,Phosphoinositide phospholipase C","-","PF09279,Phosphoinositide-specific phospholipase C, efhand-like;PF08703,PLC-beta C terminal;PF00387,Phosphatidylinositol-specific phospholipase C, Y domain;PF00168,C2 domain;PF00388,Phosphatidylinositol-specific phospholipase C, X domain","-","-","-","-"]
["ZNF331",2.61181578,0.805590768,1.691437792,3.81503408,{"v":2.9E-5,"d":"2.90E-05"},{"v":9.92e-05,"d":"9.92E-05"},"ENSG00000130844","G3R635,Zinc finger protein 331","XP_004061421.2,zinc finger protein 331;XP_004061422.2,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["TBC1D4",2.710569396,0.836629403,1.689796921,3.662950001,{"v":4.93e-05,"d":"4.93E-05"},1.59896E-4,"ENSG00000136111","A0A024R637,TBC1 domain family, member 4, isoform CRA_b","-","PF00640,Phosphotyrosine interaction domain (PTB/PID);PF00566,Rab-GTPase-TBC domain;PF11830,omain of unknown function (DUF3350)","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain;IPR021785,Domain of unknown function DUF3350;IPR011993,PH-like domain superfamily;IPR033564,TBC1 domain family member 4;IPR006020,PTB/PI domain","ENOG410YWJY,-;KOG4436,Predicted GTPase activator NB4S/EVI5 (contains TBC domain)/Calmodulin-binding protein Pollux (contains PTB and TBC domains)","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity","-"]
["PPP2R3A",2.302790742,0.710766692,1.689796921,3.662950001,{"v":4.93e-05,"d":"4.93E-05"},1.59896E-4,"ENSG00000073711","B2RAL3,cDNA, FLJ94988, highly similar to Homo sapiens protein phosphatase 2","-","PF13499,-hand domain pair","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR011992,EF-hand domain pair","KOG2562,Protein phosphatase 2 regulatory subunit;ENOG410XRBK,-","GO:0005509,molecular_function,calcium ion binding","-"]
["NSUN6",1.832882768,0.562029923,1.688080088,2.301273031,0.017311675,0.030736627,"ENSG00000241058","G3R1M9,NOP2/Sun RNA methyltransferase family member 6","XP_004049161.1,putative methyltransferase NSUN6 isoform X2","PF13847,Methyltransferase domain;PF01189,16S rRNA methyltransferase RsmB/F;PF01728,tsJ-like methyltransferase","IPR015947,PUA-like superfamily;IPR023267,RNA (C5-cytosine) methyltransferase;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR018314,Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site;IPR001678,SAM-dependent methyltransferase RsmB/NOP2-type;IPR002478,PUA domain;IPR036974,PUA domain superfamily","-","GO:0016428,molecular_function,tRNA (cytosine-5-)-methyltransferase activity;GO:0030488,biological_process,tRNA methylation;GO:0016740,molecular_function,transferase activity;GO:0003723,molecular_function,RNA binding;GO:0005737,cellular_component,cytoplasm;GO:0008168,molecular_function,methyltransferase activity;GO:0000049,molecular_function,tRNA binding;GO:0032259,biological_process,methylation","-"]
["RP11-365N19.2",7.743265607,2.37437279,1.688080088,2.301273031,0.017311675,0.030736627,"-","-","-","-","-","-","-","-"]
["AC012613.2",1.414388688,0.433704097,1.688080088,2.301273031,0.017311675,0.030736627,"ENSG00000253406","A0A286XUS0,Actin binding LIM protein family member 3","-","-","IPR028449,Actin-binding LIM protein 3;IPR001781,Zinc finger, LIM-type;IPR003128,Villin headpiece;IPR036886,Villin headpiece domain superfamily;IPR032402,Putative adherens-junction anchoring domain","-","GO:0030036,biological_process,actin cytoskeleton organization;GO:0007010,biological_process,cytoskeleton organization;GO:0003779,molecular_function,actin binding;GO:0046872,molecular_function,metal ion binding;GO:0006351,biological_process,transcription, DNA-templated","-"]
["JAG1",7.429324911,2.303703621,1.687535356,5.409095657,{"v":3.26e-09,"d":"3.26E-09"},{"v":2.66E-8,"d":"2.66E-08"},"ENSG00000101384","H2P116,Delta-like protein","XP_002829998.1,protein jagged-1","PF07657,N terminus of Notch ligand;PF00008,-like domain;PF01414,elta serrate ligand;PF07645,Calcium-binding EGF domain;PF12661,Human growth factor-like EGF","IPR018097,EGF-like calcium-binding, conserved site;IPR026219,Jagged/Serrate protein;IPR001774,Delta/Serrate/lag-2 (DSL) protein;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011651,Notch ligand, N-terminal domain;IPR001881,EGF-like calcium-binding domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR001007,VWFC domain","ENOG410XP6K,-;KOG1217,Fibrillins and related proteins containing Ca2+-binding EGF-like domains","GO:0022408,biological_process,negative regulation of cell-cell adhesion;GO:0005912,cellular_component,adherens junction;GO:0045639,biological_process,positive regulation of myeloid cell differentiation;GO:0002456,biological_process,T cell mediated immunity;GO:0072070,biological_process,loop of Henle development;GO:0045669,biological_process,positive regulation of osteoblast differentiation;GO:0045665,biological_process,negative regulation of neuron differentiation;GO:0005886,cellular_component,plasma membrane;GO:0001953,biological_process,negative regulation of cell-matrix adhesion;GO:0009887,biological_process,animal organ morphogenesis;GO:0005112,molecular_function,Notch binding;GO:0030336,biological_process,negative regulation of cell migration;GO:0061309,biological_process,cardiac neural crest cell development involved in outflow tract morphogenesis;GO:0045747,biological_process,positive regulation of Notch signaling pathway;GO:0045599,biological_process,negative regulation of fat cell differentiation;GO:0003184,biological_process,pulmonary valve morphogenesis;GO:2000737,biological_process,negative regulation of stem cell differentiation;GO:0002011,biological_process,morphogenesis of an epithelial sheet;GO:0001974,biological_process,blood vessel remodeling;GO:0072017,biological_process,distal tubule development;GO:0045177,cellular_component,apical part of cell;GO:0061073,biological_process,ciliary body morphogenesis;GO:0042127,biological_process,regulation of cell proliferation;GO:0072006,biological_process,nephron development;GO:0045596,biological_process,negative regulation of cell differentiation;GO:0060411,biological_process,cardiac septum morphogenesis;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0035909,biological_process,aorta morphogenesis;GO:0016324,cellular_component,apical plasma membrane;GO:0032495,biological_process,response to muramyl dipeptide;GO:0097150,biological_process,neuronal stem cell population maintenance;GO:0016020,cellular_component,membrane;GO:0005509,molecular_function,calcium ion binding;GO:0016021,cellular_component,integral component of membrane;GO:0061156,biological_process,pulmonary artery morphogenesis;GO:0061444,biological_process,endocardial cushion cell development;GO:0043010,biological_process,camera-type eye development;GO:0007219,biological_process,Notch signaling pathway;GO:0003215,biological_process,cardiac right ventricle morphogenesis;GO:0005543,molecular_function,phospholipid binding;GO:0048839,biological_process,inner ear development;GO:0042491,biological_process,inner ear auditory receptor cell differentiation;GO:0007154,biological_process,cell communication;GO:0061314,biological_process,Notch signaling involved in heart development;GO:0045602,biological_process,negative regulation of endothelial cell differentiation;GO:0072015,biological_process,glomerular visceral epithelial cell development;GO:0007275,biological_process,multicellular organism development","K06052,ko01522,Endocrine resistance;K06052,ko04330,Notch signaling pathway"]
["ANKMY2",18.13816106,5.625616261,1.686814511,5.123466639,{"v":1.86e-08,"d":"1.86E-08"},{"v":1.29E-7,"d":"1.29E-07"},"ENSG00000106524","H2PMS0,Ankyrin repeat and MYND domain containing 2","XP_002818230.1,-","PF12796,Ankyrin repeats (3 copies);PF01753,MYND finger","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR002893,Zinc finger, MYND-type;IPR036770,Ankyrin repeat-containing domain superfamily","ENOG410XPNY,-;KOG1710,MYND Zn-finger and ankyrin repeat protein","GO:0019899,molecular_function,enzyme binding;GO:0046872,molecular_function,metal ion binding","-"]
["SLC25A13",11.39296654,3.532759516,1.686666528,4.83903577,{"v":8.59e-08,"d":"8.59E-08"},{"v":5.12e-07,"d":"5.12E-07"},"ENSG00000004864","G3QSP5,Solute carrier family 25 member 13","XP_018886797.1,calcium-binding mitochondrial carrier protein Aralar2","PF00153,Mitochondrial carrier protein","IPR018108,Mitochondrial substrate/solute carrier;IPR023395,Mitochondrial carrier domain superfamily;IPR002048,EF-hand domain;IPR002067,Mitochondrial carrier protein;IPR011992,EF-hand domain pair","-","GO:0055085,biological_process,transmembrane transport;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005509,molecular_function,calcium ion binding","-"]
["CPM",4.348971473,1.348051333,1.686432878,4.484014361,{"v":7.11e-07,"d":"7.11E-07"},{"v":3.47e-06,"d":"3.47E-06"},"ENSG00000135678","H2Q6F7,Carboxypeptidase M","XP_016779331.1,-;XP_009424079.1,-","PF00246,Zinc carboxypeptidase;PF13620,Carboxypeptidase regulatory-like domain","IPR000834,Peptidase M14, carboxypeptidase A;IPR008969,Carboxypeptidase-like, regulatory domain superfamily;IPR033842,Carboxypeptidase M N-terminal domain","ENOG410XX0H,-;KOG2649,Zinc carboxypeptidase","GO:0006508,biological_process,proteolysis;GO:0009986,cellular_component,cell surface;GO:0016485,biological_process,protein processing;GO:0004181,molecular_function,metallocarboxypeptidase activity;GO:0006518,biological_process,peptide metabolic process;GO:0004185,molecular_function,serine-type carboxypeptidase activity;GO:0008270,molecular_function,zinc ion binding;GO:0005615,cellular_component,extracellular space","-"]
["LANCL1",4.429214739,1.372020516,1.686008872,4.01107123,{"v":8.29e-06,"d":"8.29E-06"},{"v":3.21e-05,"d":"3.21E-05"},"ENSG00000115365","K7CEJ6,LanC lantibiotic synthetase component C-like 1","-","PF05147,Lanthionine synthetase C-like protein","IPR012341,Six-hairpin glycosidase-like superfamily;IPR020464,LanC-like protein, eukaryotic;IPR007822,Lanthionine synthetase C-like","ENOG410XQIA,-;KOG2787,Lanthionine synthetase C-like protein 1","GO:0003824,molecular_function,catalytic activity","-"]
["LRPPRC",19.34229667,6.009401298,1.685882548,6.962515045,1.57E-12,{"v":2.71e-11,"d":"2.71E-11"},"ENSG00000138095","E5KNY5,Leucine-rich PPR-motif containing","NP_573566.2,leucine-rich PPR motif-containing protein, mitochondrial precursor","PF17177,Pentacotripeptide-repeat region of PRORP;PF13812,Pentatricopeptide repeat domain;PF01535,PPR repeat","IPR033443,Pentacotripeptide-repeat region of PRORP;IPR002885,Pentatricopeptide repeat;IPR033490,Leucine-rich PPR motif-containing protein;IPR011990,Tetratricopeptide-like helical domain superfamily","KOG4318,Bicoid mRNA stability factor;ENOG410XSG9,-","GO:0003697,molecular_function,single-stranded DNA binding;GO:0000961,biological_process,negative regulation of mitochondrial RNA catabolic process;GO:0005737,cellular_component,cytoplasm;GO:0070129,biological_process,regulation of mitochondrial translation;GO:0003723,molecular_function,RNA binding;GO:0005739,cellular_component,mitochondrion;GO:0005634,cellular_component,nucleus;GO:0030529,,","-"]
["MCL1",57.15124064,17.76624033,1.685205857,7.364032891,{"v":3.49e-13,"d":"3.49E-13"},{"v":7.09e-12,"d":"7.09E-12"},"ENSG00000143384","I2CUN5,Induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1","-","PF00452,Apoptosis regulator proteins, Bcl-2 family","IPR020717,Apoptosis regulator, Bcl-2, BH1 motif, conserved site;IPR002475,Bcl2-like;IPR026298,Blc2 family;IPR020728,Apoptosis regulator, Bcl-2, BH3 motif, conserved site;IPR020726,Apoptosis regulator, Bcl-2, BH2 motif, conserved site;IPR013281,Apoptosis regulator, Mcl-1;IPR036834,Blc2-like superfamily","ENOG41123S0,-;KOG4728,Anti-apoptotic Bcl-2 family proteins, prevent opening of mitochondrial porin channel","GO:0042981,biological_process,regulation of apoptotic process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SH2B1",6.646890001,2.063660606,1.685155089,5.002737241,{"v":3.95e-08,"d":"3.95E-08"},{"v":2.55e-07,"d":"2.55E-07"},"ENSG00000178188","A0A024QZD2,SH2-B homolog, isoform CRA_c","XP_016878605.1,-;XP_016878604.1,-;NP_001139267.1,SH2B adapter protein 1 isoform 1;NP_001295222.1,-;XP_016878603.1,-","PF00017,SH2 domain;PF08916,Phenylalanine zipper;PF00169,PH domain","IPR035057,SH2B1, SH2 domain;IPR030521,SH2B adapter protein 1;IPR036860,SH2 domain superfamily;IPR030523,SH2B adapter protein;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR015012,Phenylalanine zipper;IPR036290,Phenylalanine zipper superfamily;IPR000980,SH2 domain","ENOG41102PH,-;ENOG410IMWK,-","GO:0035591,molecular_function,signaling adaptor activity;GO:0035556,biological_process,intracellular signal transduction;GO:0009967,biological_process,positive regulation of signal transduction;GO:0030032,biological_process,lamellipodium assembly;GO:0004871,molecular_function,signal transducer activity;GO:0005622,cellular_component,intracellular;GO:0045840,biological_process,positive regulation of mitotic nuclear division;GO:2000278,biological_process,regulation of DNA biosynthetic process;GO:0007165,biological_process,signal transduction","K12459,ko04722,Neurotrophin signaling pathway"]
["INPP1",3.746650823,1.158766264,1.685001988,3.299210949,0.000294925,0.000804037,"ENSG00000151689","Q6IBG4,INPP1 protein","XP_005246589.1,-;NP_001122400.1,-;NP_002185.1,inositol polyphosphate 1-phosphatase","PF00459,Inositol monophosphatase family","IPR020550,Inositol monophosphatase, conserved site;IPR000760,Inositol monophosphatase-like;IPR020583,Inositol monophosphatase, metal-binding site","KOG3099,Bisphosphate 3'-nucleotidase BPNT1/Inositol polyphosphate 1-phosphatase;ENOG410XNMV,-","GO:0046854,biological_process,phosphatidylinositol phosphorylation","K01107,ko00562,Inositol phosphate metabolism;K01107,ko04070,Phosphatidylinositol signaling system"]
["GALNT7",18.88612372,5.870736161,1.684864651,6.425734532,{"v":1.69e-11,"d":"1.69E-11"},2.32E-10,"ENSG00000109586","H2QQF5,Polypeptide N-acetylgalactosaminyltransferase","XP_003310650.1,N-acetylgalactosaminyltransferase 7 isoform X1","PF00535,lycosyl transferase family 2;PF00652,Ricin-type beta-trefoil lectin domain","IPR035992,Ricin B-like lectins;IPR000772,Ricin B, lectin domain;IPR029044,Nucleotide-diphospho-sugar transferases;IPR001173,Glycosyltransferase 2-like","ENOG410XPMK,-;KOG3736,Polypeptide N-acetylgalactosaminyltransferase","GO:0005794,cellular_component,Golgi apparatus;GO:0006486,biological_process,protein glycosylation;GO:0016740,molecular_function,transferase activity;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0030246,molecular_function,carbohydrate binding;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K00710,ko00512,Mucin type O-Glycan biosynthesis"]
["ZNF865",5.276892117,1.636271886,1.684065999,3.879429276,{"v":2.25e-05,"d":"2.25E-05"},{"v":7.91e-05,"d":"7.91E-05"},"ENSG00000261221","A0A1D5QLN5,Zinc finger protein 865","-","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["PTCD3",6.635053253,2.063209414,1.68358788,5.497217974,{"v":2.49e-09,"d":"2.49E-09"},{"v":2.09e-08,"d":"2.09E-08"},"ENSG00000132300","G2HI34,Pentatricopeptide repeat domain 3","NP_001267143.1,pentatricopeptide repeat domain-containing protein 3, mitochondrial","PF13041,PPR repeat family;PF13812,Pentatricopeptide repeat domain","IPR002885,Pentatricopeptide repeat;IPR037387,Pentatricopeptide repeat domain-containing protein 3;IPR011990,Tetratricopeptide-like helical domain superfamily","ENOG410XNQS,-;KOG4422,Uncharacterized conserved protein","GO:0019843,molecular_function,rRNA binding;GO:0043024,molecular_function,ribosomal small subunit binding;GO:0032543,biological_process,mitochondrial translation;GO:0005739,cellular_component,mitochondrion","-"]
["RPL15P3",106.1813658,33.03273755,1.682880085,5.451856036,{"v":2.38e-09,"d":"2.38E-09"},{"v":2.01e-08,"d":"2.01E-08"},"ENSG00000212802","A0A091D320,Ribosomal protein L15","XP_010638454.1,-","PF00827,Ribosomal L15","IPR024794,Ribosomal protein L15e core domain superfamily;IPR012678,Ribosomal protein L23/L15e core domain superfamily;IPR020925,Ribosomal protein L15e, conserved site;IPR000439,Ribosomal protein L15e","-","GO:0006412,biological_process,translation;GO:0005840,cellular_component,ribosome;GO:0030529,,;GO:0003735,molecular_function,structural constituent of ribosome;GO:0005622,cellular_component,intracellular","-"]
["CCNY",12.65241241,3.936753911,1.682822556,5.602960583,{"v":1.37E-9,"d":"1.37E-09"},{"v":1.22E-8,"d":"1.22E-08"},"ENSG00000108100","G3QP36,Cyclin Y","-","PF00134,Cyclin, N-terminal domain","IPR012399,Cyclin Y;IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","-","GO:0060828,biological_process,regulation of canonical Wnt signaling pathway;GO:0000079,biological_process,regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0016538,molecular_function,cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019901,molecular_function,protein kinase binding;GO:0005886,cellular_component,plasma membrane;GO:0000086,biological_process,G2/M transition of mitotic cell cycle;GO:0000308,cellular_component,cytoplasmic cyclin-dependent protein kinase holoenzyme complex;GO:0005634,cellular_component,nucleus;GO:0045737,biological_process,positive regulation of cyclin-dependent protein serine/threonine kinase activity","-"]
["CTD-2410N18.4",23.54189406,7.323137168,1.682024237,4.800191851,{"v":1.45e-07,"d":"1.45E-07"},{"v":8.2e-07,"d":"8.20E-07"},"ENSG00000273345","B7Z2C5,cDNA FLJ50492, highly similar to Cyclin-dependent kinase-like 3","-","PF00149,Calcineurin-like phosphoesterase","IPR029052,Metallo-dependent phosphatase-like;IPR004843,Calcineurin-like phosphoesterase domain, ApaH type;IPR011009,Protein kinase-like domain superfamily;IPR006186,Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase","ENOG410XNSW,-;KOG0593,Predicted protein kinase KKIAMRE","GO:0016301,molecular_function,kinase activity;GO:0016787,molecular_function,hydrolase activity;GO:0016310,biological_process,phosphorylation","-"]
["LRFN3",2.877237171,0.891270498,1.68129829,3.075175688,0.000793692,0.001959933,"ENSG00000126243","H2QG51,Leucine rich repeat and fibronectin type III domain containing 3","XP_524229.1,leucine-rich repeat and fibronectin type-III domain-containing protein 3","PF00041,ibronectin type III domain;PF13855,Leucine rich repeat;PF07679,Immunoglobulin I-set domain","IPR001611,Leucine-rich repeat;IPR003961,Fibronectin type III;IPR007110,Immunoglobulin-like domain;IPR000483,Cysteine-rich flanking region, C-terminal;IPR036116,Fibronectin type III superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0009986,cellular_component,cell surface;GO:0007409,biological_process,axonogenesis;GO:0005578,,;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space","-"]
["TIMP3",8.46045271,2.633836078,1.680753674,4.725789623,{"v":1.85E-7,"d":"1.85E-07"},{"v":1.02E-6,"d":"1.02E-06"},"ENSG00000100234","G3RBQ3,TIMP metallopeptidase inhibitor 3","XP_004063416.1,-","PF00965,Tissue inhibitor of metalloproteinase","IPR008993,Tissue inhibitor of metalloproteinases-like, OB-fold;IPR001134,Netrin domain;IPR027465,Proteinase inhibitor I35b (TIMP), C-terminal;IPR030490,Tissue inhibitor of metalloproteinase, conserved site;IPR001820,Protease inhibitor I35 (TIMP);IPR015612,Metalloproteinase inhibitor 3","-","GO:0008191,molecular_function,metalloendopeptidase inhibitor activity;GO:0005604,cellular_component,basement membrane;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:1903984,biological_process,positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1904684,biological_process,negative regulation of metalloendopeptidase activity;GO:0031012,cellular_component,extracellular matrix;GO:0071310,biological_process,cellular response to organic substance;GO:0051045,biological_process,negative regulation of membrane protein ectodomain proteolysis;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space","K16866,ko05206,MicroRNAs in cancer;K16866,ko05205,Proteoglycans in cancer"]
["LHPP",5.959875694,1.854394497,1.679808589,4.067380658,{"v":6.6e-06,"d":"6.60E-06"},{"v":2.61e-05,"d":"2.61E-05"},"ENSG00000107902","K7AM34,Phospholysine phosphohistidine inorganic pyrophosphate phosphatase","XP_016775052.1,phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X3","PF13242,HAD-hyrolase-like;PF13344,Haloacid dehalogenase-like hydrolase","IPR006355,HAD hydrolase, LHPP/HDHD2;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR006357,HAD-superfamily hydrolase, subfamily IIA","COG0647,Predicted sugar phosphatases of the HAD superfamily;KOG3040,Predicted sugar phosphatase (HAD superfamily)","-","-"]
["COLGALT2",0.598052696,0.183385166,1.679567959,1.802987548,0.034704071,0.056925146,"ENSG00000198756","H2R415,Glycosyltransferase 25 domain containing 2","XP_524994.3,procollagen galactosyltransferase 2 isoform X1","PF13704,lycosyl transferase family 2;PF01755,lycosyltransferase family 25 (LPS biosynthesis protein)","IPR002654,Glycosyl transferase, family 25;IPR029044,Nucleotide-diphospho-sugar transferases","ENOG410XQQN,-;KOG4179,Lysyl hydrolase/glycosyltransferase family 25","GO:0016740,molecular_function,transferase activity","-"]
["QTRT1",1.246146535,0.382114805,1.679567959,1.802987548,0.034704071,0.056925146,"ENSG00000213339","H2QFC4,Queuine tRNA-ribosyltransferase catalytic subunit 1","XP_512381.1,-","PF01702,Queuine tRNA-ribosyltransferase","IPR002616,tRNA-guanine(15) transglycosylase-like;IPR004803,tRNA-guanine transglycosylase;IPR036511,Queuine tRNA-ribosyltransferase-like","COG0343,Queuine/archaeosine tRNA-ribosyltransferase;KOG3908,Queuine-tRNA ribosyltransferase","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0008033,biological_process,tRNA processing;GO:0032991,cellular_component,protein-containing complex;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0101030,biological_process,tRNA-guanine transglycosylation;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0005634,cellular_component,nucleus;GO:0016763,molecular_function,transferase activity, transferring pentosyl groups;GO:0005739,cellular_component,mitochondrion;GO:0046982,molecular_function,protein heterodimerization activity;GO:0016020,cellular_component,membrane;GO:0008479,molecular_function,queuine tRNA-ribosyltransferase activity;GO:0006400,biological_process,tRNA modification","-"]
["ZNF14",1.449400683,0.444440075,1.679567959,1.802987548,0.034704071,0.056925146,"ENSG00000105708","H2QFV9,Uncharacterized protein","XP_003316272.2,zinc finger protein 14","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["KANK1",0.358942107,0.11006498,1.679567959,1.802987548,0.034704071,0.056925146,"ENSG00000107104","A8KAC4,cDNA FLJ78754, highly similar to Homo sapiens ankyrin repeat domain 15","-","PF12796,Ankyrin repeats (3 copies);PF12075,KN motif","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR021939,Kank N-terminal motif;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0514,Ankyrin repeat protein;COG0666,FOG: Ankyrin repeat","-","-"]
["OXSR1",10.20199143,3.182245804,1.678968227,5.378936176,{"v":4.8E-9,"d":"4.80E-09"},{"v":3.78e-08,"d":"3.78E-08"},"ENSG00000172939","A0A024R2M7,Oxidative-stress responsive 1, isoform CRA_a","NP_005100.1,serine/threonine-protein kinase OSR1","PF00069,Protein kinase domain;PF12202,Oxidative-stress-responsive kinase 1 C-terminal domain","IPR011009,Protein kinase-like domain superfamily;IPR024678,Serine/threonine-protein kinase OSR1/WNK, CCT domain;IPR017441,Protein kinase, ATP binding site;IPR028749,Serine/threonine-protein kinase OSR1;IPR000719,Protein kinase domain","ENOG410XSWS,-;KOG0582,Ste20-like serine/threonine protein kinase","GO:0023014,biological_process,signal transduction by protein phosphorylation;GO:0035556,biological_process,intracellular signal transduction;GO:0005524,molecular_function,ATP binding;GO:0004702,molecular_function,signal transducer, downstream of receptor, with serine/threonine kinase activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006979,biological_process,response to oxidative stress;GO:1901380,biological_process,negative regulation of potassium ion transmembrane transport;GO:0005829,cellular_component,cytosol;GO:0071476,biological_process,cellular hypotonic response;GO:0006468,biological_process,protein phosphorylation;GO:1901017,biological_process,negative regulation of potassium ion transmembrane transporter activity;GO:0018107,biological_process,peptidyl-threonine phosphorylation;GO:0004672,molecular_function,protein kinase activity","-"]
["AP1S3",3.935497272,1.223766368,1.678719112,3.572934973,{"v":8.66e-05,"d":"8.66E-05"},0.000264661,"ENSG00000152056","G7PK67,AP complex subunit sigma","-","PF01217,Clathrin adaptor complex small chain","IPR011012,Longin-like domain superfamily;IPR022775,AP complex, mu/sigma subunit;IPR000804,Clathrin adaptor complex, small chain;IPR016635,Adaptor protein complex, sigma subunit","-","GO:0015031,biological_process,protein transport;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0030117,cellular_component,membrane coat;GO:0008565,molecular_function,protein transporter activity;GO:0006886,biological_process,intracellular protein transport","-"]
["CAT",10.35828539,3.230622554,1.677747541,4.564306927,{"v":6.46e-07,"d":"6.46E-07"},{"v":3.18E-6,"d":"3.18E-06"},"ENSG00000121691","H2Q3E5,Catalase","XP_001147928.1,catalase","PF00199,Catalase;PF06628,Catalase-related immune-responsive","IPR018028,Catalase, mono-functional, haem-containing;IPR011614,Catalase core domain;IPR024708,Catalase active site;IPR010582,Catalase immune-responsive domain;IPR020835,Catalase superfamily;IPR037060,Catalase core domain superfamily;IPR002226,Catalase haem-binding site;IPR024711,Catalase, mono-functional, haem-containing, clades 1 and 3","COG0753,Catalase;KOG0047,Catalase","GO:0016209,molecular_function,antioxidant activity;GO:0005102,molecular_function,signaling receptor binding;GO:0009060,biological_process,aerobic respiration;GO:0000302,biological_process,response to reactive oxygen species;GO:0042542,biological_process,response to hydrogen peroxide;GO:0008203,biological_process,cholesterol metabolic process;GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0042803,molecular_function,protein homodimerization activity;GO:0004046,molecular_function,aminoacylase activity;GO:0009650,biological_process,UV protection;GO:0050661,molecular_function,NADP binding;GO:0004096,molecular_function,catalase activity;GO:0005739,cellular_component,mitochondrion;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity;GO:0016684,molecular_function,oxidoreductase activity, acting on peroxide as acceptor;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0005777,cellular_component,peroxisome;GO:0098869,biological_process,cellular oxidant detoxification;GO:0016491,molecular_function,oxidoreductase activity;GO:0006979,biological_process,response to oxidative stress;GO:0055114,biological_process,oxidation-reduction process;GO:0020037,molecular_function,heme binding;GO:0051262,biological_process,protein tetramerization;GO:0019899,molecular_function,enzyme binding;GO:0004601,molecular_function,peroxidase activity;GO:0020027,biological_process,hemoglobin metabolic process;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0046872,molecular_function,metal ion binding;GO:0005778,cellular_component,peroxisomal membrane;GO:0051289,biological_process,protein homotetramerization;GO:0042744,biological_process,hydrogen peroxide catabolic process;GO:0006641,biological_process,triglyceride metabolic process","K03781,ko05014,Amyotrophic lateral sclerosis (ALS);K03781,ko04212,Longevity regulating pathway - worm;K03781,ko00630,Glyoxylate and dicarboxylate metabolism;K03781,ko04213,Longevity regulating pathway - multiple species;K03781,ko04011,MAPK signaling pathway - yeast;K03781,ko00380,Tryptophan metabolism;K03781,ko04068,FoxO signaling pathway;K03781,ko04211,Longevity regulating pathway;K03781,ko04146,Peroxisome;K03781,ko01200,Carbon metabolism"]
["TANGO2",3.586778222,1.117578747,1.677360148,3.941051579,{"v":1.36E-5,"d":"1.36E-05"},{"v":5.01e-05,"d":"5.01E-05"},"ENSG00000183597","G3QQ73,Transport and golgi organization 2 homolog","-","PF05742,Transport and Golgi organisation 2","IPR008551,Transport and Golgi organisation protein 2","-","GO:0005794,cellular_component,Golgi apparatus","-"]
["AFAP1-AS1",5.870979309,1.832407787,1.677122099,4.760266075,{"v":2.03E-7,"d":"2.03E-07"},{"v":1.12e-06,"d":"1.12E-06"},"ENSG00000272620","A0A096NZB1,Actin filament associated protein 1","-","PF00169,PH domain","IPR030113,Actin-filament associated protein;IPR011993,PH-like domain superfamily;IPR001849,Pleckstrin homology domain;IPR029907,Actin filament-associated protein 1","-","GO:0009966,biological_process,regulation of signal transduction;GO:0051493,biological_process,regulation of cytoskeleton organization","-"]
["SAMD5",1.502912312,0.466609336,1.675950747,2.808951417,1.72226E-3,0.003949323,"ENSG00000203727","H2R6W4,Sterile alpha motif domain containing 5","-","PF00536,SAM domain (Sterile alpha motif)","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","ENOG4111JDA,-;ENOG410INAV,-","-","-"]
["TMEM2",4.465484291,1.395761169,1.675227788,4.864975879,{"v":9.05e-08,"d":"9.05E-08"},{"v":5.37E-7,"d":"5.37E-07"},"ENSG00000135048","A0A024R229,Transmembrane protein 2, isoform CRA_b","XP_005251926.1,-;NP_037522.1,cell surface hyaluronidase isoform a","PF10162,8 domain;PF15711,Interleukin-like EMT inducer","IPR011050,Pectin lyase fold/virulence factor;IPR019316,G8 domain","ENOG410XQ01,-;ENOG410IFCM,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ULK3",4.18729494,1.304689486,1.67489631,3.3907833,1.58383E-4,0.000459399,"ENSG00000140474","H2NNS8,Unc-51 like kinase 3","-","PF00069,Protein kinase domain;PF04212,MIT (microtubule interacting and transport) domain","IPR007330,MIT;IPR000719,Protein kinase domain;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR036181,MIT domain superfamily","KOG0595,Serine/threonine-protein kinase involved in autophagy;ENOG410XR01,-","GO:0045879,biological_process,negative regulation of smoothened signaling pathway;GO:0005737,cellular_component,cytoplasm;GO:0046777,biological_process,protein autophosphorylation;GO:0045880,biological_process,positive regulation of smoothened signaling pathway;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["EMB",2.800557163,0.872605713,1.67489631,3.3907833,1.58383E-4,0.000459399,"ENSG00000170571","H2QQV1,Embigin","-","PF00047,Immunoglobulin domain;PF07679,Immunoglobulin I-set domain","IPR007110,Immunoglobulin-like domain;IPR013151,Immunoglobulin;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR027114,Embigin;IPR003599,Immunoglobulin subtype;IPR013098,Immunoglobulin I-set","ENOG410IVBC,-;ENOG41120A3,-","-","-"]
["IFT140",7.18078549,2.246468282,1.67462562,5.302121021,{"v":6.95e-09,"d":"6.95E-09"},{"v":5.31e-08,"d":"5.31E-08"},"ENSG00000187535","K7ANH9,Intraflagellar transport 140 homolog","XP_016784643.1,intraflagellar transport protein 140 homolog isoform X2","-","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain;IPR011990,Tetratricopeptide-like helical domain superfamily","KOG3617,WD40 and TPR repeat-containing protein;ENOG410XSS4,-","GO:0031514,cellular_component,motile cilium","-"]
["POLRMT",4.912329313,1.534723396,1.674099227,4.121560988,{"v":6.89e-06,"d":"6.89E-06"},{"v":2.72E-5,"d":"2.72E-05"},"ENSG00000099821","Q4G0F4,DNA-directed RNA polymerase","NP_005026.3,DNA-directed RNA polymerase, mitochondrial precursor","PF00940,NA-dependent RNA polymerase;PF14700,NA-directed RNA polymerase N-terminal","IPR037159,DNA-directed RNA polymerase, N-terminal domain superfamily;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR029262,DNA-directed RNA polymerase, N-terminal;IPR002092,DNA-directed RNA polymerase, phage-type","KOG1038,Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation;COG5108,Mitochondrial DNA-directed RNA polymerase","GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0003677,molecular_function,DNA binding;GO:0016740,molecular_function,transferase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0006351,biological_process,transcription, DNA-templated","-"]
["NACC2",4.214489545,1.31755961,1.673906017,4.38230573,{"v":1.59E-6,"d":"1.59E-06"},{"v":7.24e-06,"d":"7.24E-06"},"ENSG00000148411","A0A024R8I0,BTB","XP_011516523.1,-;NP_653254.1,nucleus accumbens-associated protein 2","PF00651,BTB/POZ domain;PF10523,BEN domain","IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily;IPR018379,BEN domain","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0005739,cellular_component,mitochondrion;GO:0005730,cellular_component,nucleolus","-"]
["ZNF398",5.896212844,1.844157777,1.673769443,4.602831244,{"v":5.46e-07,"d":"5.46E-07"},{"v":2.73e-06,"d":"2.73E-06"},"ENSG00000197024","A0A090N7S8,Zinc finger protein 398","NP_733787.1,zinc finger protein 398 isoform a","PF12417,Zinc finger protein;PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR022137,Protein of unknown function DUF3669, zinc finger protein;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily;IPR001909,Krueppel-associated box","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["OSBPL2",4.63386223,1.451938572,1.672236118,5.196023583,{"v":1.34e-08,"d":"1.34E-08"},{"v":9.64e-08,"d":"9.64E-08"},"ENSG00000130703","H2QKQ4,Oxysterol-binding protein","XP_009435826.1,-;XP_001144767.1,oxysterol-binding protein-related protein 2","PF01237,Oxysterol-binding protein","IPR000648,Oxysterol-binding protein;IPR018494,Oxysterol-binding protein, conserved site;IPR037239,Oxysterol-binding protein superfamily","KOG1737,Oxysterol-binding protein;ENOG410XP9E,-","GO:0006869,biological_process,lipid transport;GO:0015485,molecular_function,cholesterol binding","-"]
["ITGBL1",16.92297764,5.307150066,1.671934661,6.12111601,{"v":8.91e-11,"d":"8.91E-11"},{"v":1.03E-9,"d":"1.03E-09"},"ENSG00000198542","A0A024RDW7,Integrin, beta-like 1","NP_004782.1,integrin beta-like protein 1 isoform 1 precursor;XP_005254157.1,-","PF07974,-like domain","IPR013111,EGF-like domain, extracellular;IPR027070,Integrin beta-like protein 1;IPR015812,Integrin beta subunit;IPR000742,EGF-like domain","KOG1226,Integrin beta subunit (N-terminal portion of extracellular region);ENOG410XP60,-","GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0005615,cellular_component,extracellular space","-"]
["FCHSD2",5.446753525,1.705264652,1.671555033,4.281830745,{"v":2.28e-06,"d":"2.28E-06"},{"v":1e-05,"d":"1.00E-05"},"ENSG00000137478","E9PG19,F-BAR and double SH3 domains protein 2","-","PF14604,Variant SH3 domain;PF00018,SH3 domain;PF00611,es/CIP4, and EFC/F-BAR homology domain","IPR034934,F-BAR and double SH3 domains protein 2;IPR035460,FCHSD, SH3 domain 1;IPR031160,F-BAR domain;IPR001060,FCH domain;IPR034936,F-BAR and double SH3 domains protein;IPR035556,FCHSD2, SH3 domain 2;IPR027267,AH/BAR domain superfamily;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain","ENOG410INNZ,-;ENOG410XSX6,-","-","-"]
["INSR",2.203964606,0.689751774,1.671233837,4.000130887,{"v":1.07e-05,"d":"1.07E-05"},{"v":4.04e-05,"d":"4.04E-05"},"ENSG00000171105","K7CJP0,Tyrosine-protein kinase receptor","XP_016790339.1,insulin receptor isoform X1;XP_016790340.1,-","PF00041,ibronectin type III domain;PF00757,urin-like cysteine rich region;PF01030,Receptor L domain;PF07714,Protein tyrosine kinase","IPR013783,Immunoglobulin-like fold;IPR003961,Fibronectin type III;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR006212,Furin-like repeat;IPR000494,Receptor L-domain;IPR036116,Fibronectin type III superfamily;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR002011,Tyrosine-protein kinase, receptor class II, conserved site;IPR008266,Tyrosine-protein kinase, active site;IPR006211,Furin-like cysteine-rich domain;IPR036941,Receptor L-domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR016246,Tyrosine-protein kinase, insulin-like receptor;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG4258,Insulin/growth factor receptor (contains protein kinase domain)","GO:0046777,biological_process,protein autophosphorylation;GO:0016301,molecular_function,kinase activity;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0043560,molecular_function,insulin receptor substrate binding;GO:0043548,molecular_function,phosphatidylinositol 3-kinase binding;GO:0016740,molecular_function,transferase activity;GO:0004714,molecular_function,transmembrane receptor protein tyrosine kinase activity;GO:0016310,biological_process,phosphorylation;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation","K04527,ko04152,AMPK signaling pathway;K04527,ko04213,Longevity regulating pathway - multiple species;K04527,ko04072,Phospholipase D signaling pathway;K04527,ko04212,Longevity regulating pathway - worm;K04527,ko04931,Insulin resistance;K04527,ko04014,Ras signaling pathway;K04527,ko04520,Adherens junction;K04527,ko04910,Insulin signaling pathway;K04527,ko04960,Aldosterone-regulated sodium reabsorption;K04527,ko04930,Type II diabetes mellitus;K04527,ko04015,Rap1 signaling pathway;K04527,ko04151,PI3K-Akt signaling pathway;K04527,ko04211,Longevity regulating pathway;K04527,ko04150,mTOR signaling pathway;K04527,ko04913,Ovarian steroidogenesis;K04527,ko04066,HIF-1 signaling pathway;K04527,ko04022,cGMP-PKG signaling pathway;K04527,ko04932,Non-alcoholic fatty liver disease (NAFLD);K04527,ko04923,Regulation of lipolysis in adipocytes;K04527,ko04068,FoxO signaling pathway"]
["RTN4",35.81202071,11.24432051,1.670791583,7.297589776,{"v":6.41e-13,"d":"6.41E-13"},{"v":1.22e-11,"d":"1.22E-11"},"ENSG00000115310","H2P670,Reticulon","-","PF02453,Reticulon","IPR003388,Reticulon","ENOG410XPKH,-;KOG1792,Reticulon","GO:0033601,biological_process,positive regulation of mammary gland epithelial cell proliferation;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0021801,biological_process,cerebral cortex radial glia guided migration;GO:0007413,biological_process,axonal fasciculation;GO:0071786,biological_process,endoplasmic reticulum tubular network organization;GO:0005783,cellular_component,endoplasmic reticulum;GO:1905943,biological_process,negative regulation of formation of growth cone in injured axon;GO:0071782,cellular_component,endoplasmic reticulum tubular network;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0005635,cellular_component,nuclear envelope;GO:1905580,biological_process,positive regulation of ERBB3 signaling pathway;GO:0044294,cellular_component,dendritic growth cone;GO:0060317,biological_process,cardiac epithelial to mesenchymal transition;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0030517,biological_process,negative regulation of axon extension;GO:1905552,biological_process,positive regulation of protein localization to endoplasmic reticulum;GO:0010634,biological_process,positive regulation of epithelial cell migration;GO:0042995,cellular_component,cell projection;GO:0016021,cellular_component,integral component of membrane;GO:0098826,cellular_component,endoplasmic reticulum tubular network membrane;GO:0048694,biological_process,positive regulation of collateral sprouting of injured axon;GO:0030424,cellular_component,axon;GO:0005622,cellular_component,intracellular;GO:0030308,biological_process,negative regulation of cell growth;GO:0007399,biological_process,nervous system development;GO:1990809,biological_process,endoplasmic reticulum tubular network membrane organization;GO:0051292,biological_process,nuclear pore complex assembly;GO:0016020,cellular_component,membrane;GO:0051960,biological_process,regulation of nervous system development;GO:0071787,biological_process,endoplasmic reticulum tubular network formation;GO:0043025,cellular_component,neuronal cell body;GO:0050821,biological_process,protein stabilization;GO:0001525,biological_process,angiogenesis;GO:1903860,biological_process,negative regulation of dendrite extension;GO:0045296,molecular_function,cadherin binding;GO:0014069,cellular_component,postsynaptic density;GO:0051897,biological_process,positive regulation of protein kinase B signaling;GO:2000172,biological_process,regulation of branching morphogenesis of a nerve","-"]
["CTC-435M10.3",17.8069815,5.584379124,1.670378055,4.82683474,{"v":1.25e-07,"d":"1.25E-07"},{"v":7.19e-07,"d":"7.19E-07"},"ENSG00000255730","F5H5P2,Uncharacterized protein","-","PF00676,ehydrogenase E1 component","IPR029061,Thiamin diphosphate-binding fold;IPR034616,2-oxoisovalerate dehydrogenase subunit alpha;IPR001017,Dehydrogenase, E1 component","COG1071,Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit;KOG1182,Branched chain alpha-keto acid dehydrogenase complex, alpha subunit","GO:0016624,molecular_function,oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;GO:0009083,biological_process,branched-chain amino acid catabolic process;GO:0003826,molecular_function,alpha-ketoacid dehydrogenase activity;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0003863,molecular_function,3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity","-"]
["SLC16A1-AS1",1.241407349,0.387843888,1.669794544,3.181806463,0.000560744,1.436023E-3,"ENSG00000226419","K7ET80,Uncharacterized protein","-","-","-","ENOG410YYVQ,-;ENOG410JFEK,-","-","-"]
["ILF3",48.60370965,15.28025864,1.669195342,8.463837679,{"v":3.27e-14,"d":"3.27E-14"},{"v":8.3E-13,"d":"8.30E-13"},"ENSG00000129351","G3QNF4,Interleukin enhancer binding factor 3","XP_004060054.1,interleukin enhancer-binding factor 3 isoform X1;XP_018870657.1,-;XP_018870656.1,-","PF07528,ZF domain;PF00035,ouble-stranded RNA binding motif","IPR033099,Interleukin enhancer-binding factor 3;IPR014720,Double-stranded RNA-binding domain;IPR006561,DZF domain","-","GO:0003677,molecular_function,DNA binding;GO:0005730,cellular_component,nucleolus;GO:0005737,cellular_component,cytoplasm;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0003723,molecular_function,RNA binding;GO:0030529,,;GO:0045071,biological_process,negative regulation of viral genome replication;GO:0005739,cellular_component,mitochondrion;GO:0017148,biological_process,negative regulation of translation;GO:0003725,molecular_function,double-stranded RNA binding;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0005576,cellular_component,extracellular region;GO:0005654,cellular_component,nucleoplasm","-"]
["AFF1",8.938218457,2.80863104,1.668991361,6.000361321,1.86E-10,{"v":2.01e-09,"d":"2.01E-09"},"ENSG00000172493","Q14C88,AF4/FMR2 family, member 1","NP_005926.1,AF4/FMR2 family member 1 isoform 2;NP_001160165.1,AF4/FMR2 family member 1 isoform 1;NP_001300889.1,AF4/FMR2 family member 1 isoform 4;NP_001300888.1,AF4/FMR2 family member 1 isoform 3","PF05110,AF-4 proto-oncoprotein","IPR007797,Transcription factor AF4/FMR2","ENOG410IGJB,-;ENOG410XRXU,-","-","K15184,ko05202,Transcriptional misregulation in cancer"]
["DLG5",29.40797437,9.251523617,1.668086425,7.640544331,{"v":2.4e-13,"d":"2.40E-13"},{"v":5.09e-12,"d":"5.09E-12"},"ENSG00000151208","K7BTH1,Discs, large homolog 5","XP_016774206.1,disks large homolog 5 isoform X1","PF04822,Takusan;PF00625,uanylate kinase;PF16610,Unstructured region between two PDZ domains on Dlg5;PF00595,PDZ domain (Also known as DHR or GLGF)","IPR035537,Disks large homologue 5, SH3 domain;IPR036034,PDZ superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001478,PDZ domain;IPR006907,Domain of unknown function DUF622;IPR036028,SH3-like domain superfamily;IPR011029,Death-like domain superfamily;IPR008144,Guanylate kinase-like domain;IPR008145,Guanylate kinase/L-type calcium channel beta subunit;IPR001452,SH3 domain;IPR001315,CARD domain","KOG0708,Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains);KOG3528,FOG: PDZ domain;ENOG410XP9M,-","GO:0071896,biological_process,protein localization to adherens junction;GO:0045197,biological_process,establishment or maintenance of epithelial cell apical/basal polarity;GO:0060999,biological_process,positive regulation of dendritic spine development;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0045186,biological_process,zonula adherens assembly;GO:0072205,biological_process,metanephric collecting duct development;GO:0042130,biological_process,negative regulation of T cell proliferation;GO:0001837,biological_process,epithelial to mesenchymal transition;GO:0030336,biological_process,negative regulation of cell migration;GO:0005913,cellular_component,cell-cell adherens junction;GO:0008013,molecular_function,beta-catenin binding;GO:0045880,biological_process,positive regulation of smoothened signaling pathway;GO:0030859,biological_process,polarized epithelial cell differentiation;GO:0035331,biological_process,negative regulation of hippo signaling;GO:0030901,biological_process,midbrain development;GO:0030054,cellular_component,cell junction;GO:0036064,cellular_component,ciliary basal body;GO:0042981,biological_process,regulation of apoptotic process;GO:0014069,cellular_component,postsynaptic density;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0045176,biological_process,apical protein localization;GO:0060441,biological_process,epithelial tube branching involved in lung morphogenesis;GO:0030011,biological_process,maintenance of cell polarity;GO:0035332,biological_process,positive regulation of hippo signaling","-"]
["MROH7-TTC4",4.856378148,1.525090788,1.66784194,4.556916946,{"v":7.96e-07,"d":"7.96E-07"},{"v":3.84e-06,"d":"3.84E-06"},"ENSG00000271723","A0A0A0MT08,MROH7-TTC4 readthrough","-","-","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","KOG2032,Uncharacterized conserved protein;ENOG410XQE8,-","-","-"]
["PPP1R12B",1.634236132,0.513213427,1.66784194,4.556916946,{"v":7.96e-07,"d":"7.96E-07"},{"v":3.84e-06,"d":"3.84E-06"},"ENSG00000077157","A0A0A0MS24,Protein phosphatase 1 regulatory subunit 12B","-","PF12796,Ankyrin repeats (3 copies);PF15898,cGMP-dependent protein kinase interacting domain;PF13637,Ankyrin repeats (many copies)","-","-","-","-"]
["THBS3",1.592313325,0.496137598,1.667552741,2.480690622,0.007786219,0.015275341,"ENSG00000169231","Q2HIZ0,Thrombospondin 3","-","PF05735,Thrombospondin C-terminal region;PF07645,Calcium-binding EGF domain;PF11598,Cartilage oligomeric matrix protein;PF02412,Thrombospondin type 3 repeat","IPR008859,Thrombospondin, C-terminal;IPR018097,EGF-like calcium-binding, conserved site;IPR003367,Thrombospondin, type 3-like repeat;IPR001791,Laminin G domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR017897,Thrombospondin, type 3 repeat;IPR001881,EGF-like calcium-binding domain;IPR024665,Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain;IPR037349,Thrombospondin;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR028507,Thrombospondin-3;IPR028974,TSP type-3 repeat","ENOG410IFQQ,-;ENOG410XQKE,-","GO:0007155,biological_process,cell adhesion;GO:0031012,cellular_component,extracellular matrix;GO:0005509,molecular_function,calcium ion binding;GO:0030198,biological_process,extracellular matrix organization;GO:0008201,molecular_function,heparin binding;GO:0005576,cellular_component,extracellular region","-"]
["DOCK8",0.534044146,0.166399022,1.667552741,2.480690622,0.007786219,0.015275341,"ENSG00000107099","A0A096P1P1,Dedicator of cytokinesis 8","XP_003911815.1,dedicator of cytokinesis protein 8 isoform X1","PF06920,ock homology region 2;PF14429,C2 domain in Dock180 and Zizimin proteins;PF11878,omain of unknown function (DUF3398)","IPR037808,Dedicator of cytokinesis C, C2 domain;IPR010703,Dedicator of cytokinesis, C-terminal;IPR035892,C2 domain superfamily;IPR016024,Armadillo-type fold;IPR021816,Dedicator of cytokinesis C/D, N-terminal;IPR027007,DHR-1 domain;IPR027357,DHR-2 domain;IPR026791,Dedicator of cytokinesis","-","GO:0005737,cellular_component,cytoplasm;GO:0036336,biological_process,dendritic cell migration;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0031256,cellular_component,leading edge membrane;GO:0031252,cellular_component,cell leading edge;GO:0070233,biological_process,negative regulation of T cell apoptotic process;GO:0043547,biological_process,positive regulation of GTPase activity;GO:1903905,biological_process,positive regulation of establishment of T cell polarity;GO:1990869,biological_process,cellular response to chemokine;GO:2000406,biological_process,positive regulation of T cell migration;GO:0061485,biological_process,memory T cell proliferation;GO:0001771,biological_process,immunological synapse formation","-"]
["RAB3GAP1",22.92570418,7.216603256,1.666863261,6.656755075,{"v":9.16e-12,"d":"9.16E-12"},{"v":1.33e-10,"d":"1.33E-10"},"ENSG00000115839","G3SA53,RAB3 GTPase activating protein catalytic subunit 1","XP_004032637.1,rab3 GTPase-activating protein catalytic subunit isoform X1","PF13890,Rab3 GTPase-activating protein catalytic subunit","IPR026147,Rab3 GTPase-activating protein catalytic subunit","-","GO:2000786,biological_process,positive regulation of autophagosome assembly;GO:0032991,cellular_component,protein-containing complex;GO:1903233,biological_process,regulation of calcium ion-dependent exocytosis of neurotransmitter;GO:0061646,biological_process,positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization;GO:0097051,biological_process,establishment of protein localization to endoplasmic reticulum membrane;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0071782,cellular_component,endoplasmic reticulum tubular network;GO:0005096,molecular_function,GTPase activator activity;GO:0048172,biological_process,regulation of short-term neuronal synaptic plasticity;GO:0005794,cellular_component,Golgi apparatus;GO:0017137,molecular_function,Rab GTPase binding;GO:0043087,biological_process,regulation of GTPase activity;GO:0007420,biological_process,brain development;GO:0005811,cellular_component,lipid droplet;GO:0021854,biological_process,hypothalamus development;GO:1903061,biological_process,positive regulation of protein lipidation;GO:0010628,biological_process,positive regulation of gene expression;GO:0034389,biological_process,lipid particle organization;GO:0017112,molecular_function,Rab guanyl-nucleotide exchange factor activity;GO:0098794,cellular_component,postsynapse;GO:0060325,biological_process,face morphogenesis;GO:0043010,biological_process,camera-type eye development;GO:1903373,biological_process,positive regulation of endoplasmic reticulum tubular network organization;GO:0060079,biological_process,excitatory postsynaptic potential","-"]
["ZNF512B",7.742829539,2.43574786,1.666138948,4.95699103,{"v":7.65e-08,"d":"7.65E-08"},{"v":4.61e-07,"d":"4.61E-07"},"ENSG00000196700","H2QKT7,Zinc finger protein 512B","XP_016793876.1,zinc finger protein 512B isoform X2","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["SEPN1",9.178500191,2.888533987,1.66526265,4.787651108,{"v":2.12e-07,"d":"2.12E-07"},{"v":1.16e-06,"d":"1.16E-06"},"ENSG00000162430","G3R759,Selenoprotein N","-","-","IPR002048,EF-hand domain","-","GO:0005509,molecular_function,calcium ion binding","-"]
["PLP2",31.7479944,9.991301296,1.66526265,4.787651108,{"v":2.12e-07,"d":"2.12E-07"},{"v":1.16e-06,"d":"1.16E-06"},"ENSG00000102007","A0A024QYW3,Proteolipid protein 2","NP_002659.1,proteolipid protein 2","PF01284,Membrane-associating domain","IPR008253,Marvel domain","KOG4788,Members of chemokine-like factor super family and related proteins;ENOG4111IAF,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RBM12",14.42051315,4.546806982,1.664081886,6.012018235,{"v":1.98e-10,"d":"1.98E-10"},{"v":2.12e-09,"d":"2.12E-09"},"ENSG00000244462","H2QK97,RNA binding motif protein 12","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR035979,RNA-binding domain superfamily;IPR034594,RBM12, RNA recognition motif 2;IPR034591,RBM12, RNA recognition motif 1;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR034856,RBM12, RNA recognition motif 4;IPR034855,RBM12, RNA recognition motif 3;IPR034854,RBM12, RNA recognition motif 5","KOG4307,RNA binding protein RBM12/SWAN;ENOG4111WZ9,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["OTULIN",3.142611628,0.989000415,1.663937014,4.224140727,{"v":3.53e-06,"d":"3.53E-06"},{"v":1.49E-5,"d":"1.49E-05"},"ENSG00000154124","K7BWK3,Family with sequence similarity 105, member B","XP_009447082.2,ubiquitin thioesterase otulin;XP_517640.3,-","PF16218,Peptidase family C101","IPR023237,Ubiquitin thioesterase otulin;IPR023235,FAM105","ENOG4111KB3,-;ENOG410IE61,-","GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0005737,cellular_component,cytoplasm;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0071797,cellular_component,LUBAC complex;GO:0070431,biological_process,nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0010803,biological_process,regulation of tumor necrosis factor-mediated signaling pathway;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0045087,biological_process,innate immune response;GO:1990108,biological_process,protein linear deubiquitination;GO:0002040,biological_process,sprouting angiogenesis;GO:0050728,biological_process,negative regulation of inflammatory response","-"]
["INF2",4.054441772,1.277776925,1.663067401,4.712571602,{"v":2.26e-07,"d":"2.26E-07"},{"v":1.22E-6,"d":"1.22E-06"},"ENSG00000203485","H2RC71,Uncharacterized protein","XP_016782301.1,inverted formin-2 isoform X3","PF02181,ormin Homology 2 Domain;PF06367,iaphanous FH3 Domain;PF06371,iaphanous GTPase-binding Domain;PF02205,WH2 motif","IPR027649,Inverted formin-2;IPR014768,Rho GTPase-binding/formin homology 3 (GBD/FH3) domain;IPR003124,WH2 domain;IPR011989,Armadillo-like helical;IPR010473,Formin, GTPase-binding domain;IPR010472,Formin, FH3 domain;IPR016024,Armadillo-type fold;IPR015425,Formin, FH2 domain","ENOG410XQR0,-;KOG1922,Rho GTPase effector BNI1 and related formins","GO:0030036,biological_process,actin cytoskeleton organization;GO:0016043,biological_process,cellular component organization;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0090140,biological_process,regulation of mitochondrial fission;GO:0003779,molecular_function,actin binding;GO:0017048,molecular_function,Rho GTPase binding","-"]
["PARP6",6.479551781,2.043638951,1.66259527,5.076337418,{"v":4.1e-08,"d":"4.10E-08"},{"v":2.63e-07,"d":"2.63E-07"},"ENSG00000137817","I3MB71,Poly [ADP-ribose] polymerase","XP_013214947.1,-","PF00644,Poly(ADP-ribose) polymerase catalytic domain","IPR012317,Poly(ADP-ribose) polymerase, catalytic domain","ENOG410IE5T,-;ENOG410ZI9J,-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0003950,molecular_function,NAD+ ADP-ribosyltransferase activity;GO:0016740,molecular_function,transferase activity","-"]
["TNPO1",9.100292785,2.872560886,1.662588389,6.183477668,{"v":7.69e-11,"d":"7.69E-11"},8.99E-10,"ENSG00000083312","G1QXD5,Transportin 1","XP_003266098.1,-","PF13513,HEAT-like repeat;PF03810,Importin-beta N-terminal domain","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR001494,Importin-beta, N-terminal domain","KOG2023,Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily);ENOG410XPK2,-","GO:0008536,molecular_function,Ran GTPase binding;GO:0005634,cellular_component,nucleus;GO:0006886,biological_process,intracellular protein transport","-"]
["SACM1L",2.971481687,0.935926598,1.661787696,3.929551052,{"v":1.75e-05,"d":"1.75E-05"},{"v":6.33e-05,"d":"6.33E-05"},"ENSG00000211456","K7BR19,SAC1 suppressor of actin mutations 1-like","XP_016796377.1,-","PF02383,SacI homology domain","IPR002013,SAC domain","COG5329,Phosphoinositide polyphosphatase (Sac family);KOG1889,Putative phosphoinositide phosphatase","GO:0005794,cellular_component,Golgi apparatus;GO:0046856,biological_process,phosphatidylinositol dephosphorylation;GO:0042578,molecular_function,phosphoric ester hydrolase activity;GO:0032281,cellular_component,AMPA glutamate receptor complex;GO:0016020,cellular_component,membrane;GO:0043812,molecular_function,phosphatidylinositol-4-phosphate phosphatase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["MBTPS1",14.07875642,4.448644156,1.661336883,6.582413914,1.23E-11,1.73E-10,"ENSG00000140943","H2QBL9,Membrane-bound transcription factor peptidase, site 1","XP_003315258.1,membrane-bound transcription factor site-1 protease","PF00082,Subtilase family","IPR000209,Peptidase S8/S53 domain;IPR023828,Peptidase S8, subtilisin, Ser-active site;IPR034185,Site-1 peptidase catalytic domain;IPR015500,Peptidase S8, subtilisin-related;IPR022398,Peptidase S8, subtilisin, His-active site;IPR036852,Peptidase S8/S53 domain superfamily","KOG4266,Subtilisin kexin isozyme-1/site 1 protease, subtilase superfamily;COG1404,Subtilisin-like serine proteases","GO:0006508,biological_process,proteolysis;GO:0006629,biological_process,lipid metabolic process;GO:0042990,biological_process,obsolete regulation of transcription factor import into nucleus;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0004175,molecular_function,endopeptidase activity;GO:0005795,cellular_component,Golgi stack;GO:0007040,biological_process,lysosome organization","K08653,ko04141,Protein processing in endoplasmic reticulum"]
["ATP5SL",10.89465629,3.440428777,1.660709577,5.01522056,{"v":4.97e-08,"d":"4.97E-08"},{"v":3.13e-07,"d":"3.13E-07"},"ENSG00000105341","H2QGE3,Uncharacterized protein","-","-","IPR026303,Distal membrane-arm assembly complex protein 2;IPR032675,Leucine-rich repeat domain superfamily","ENOG410IS4E,-;ENOG4111PMF,-","-","-"]
["PRKAB2",5.131922554,1.620313739,1.659395193,4.272804289,{"v":2.87e-06,"d":"2.87E-06"},{"v":1.23e-05,"d":"1.23E-05"},"ENSG00000131791","G3SCS5,Protein kinase AMP-activated non-catalytic subunit beta 2","XP_018877104.1,-;XP_018877100.1,-;XP_004026557.1,-","PF16561,lycogen recognition site of AMP-activated protein kinase;PF04739,5'-AMP-activated protein kinase beta subunit, interaction domain","IPR013783,Immunoglobulin-like fold;IPR032640,AMP-activated protein kinase, glycogen-binding domain;IPR006828,Association with the SNF1 complex (ASC) domain;IPR037256,ASC domain superfamily;IPR014756,Immunoglobulin E-set","-","GO:0006468,biological_process,protein phosphorylation;GO:0031588,cellular_component,nucleotide-activated protein kinase complex;GO:0042802,molecular_function,identical protein binding;GO:0004679,molecular_function,AMP-activated protein kinase activity","K07199,ko04211,Longevity regulating pathway;K07199,ko04068,FoxO signaling pathway;K07199,ko04910,Insulin signaling pathway;K07199,ko04931,Insulin resistance;K07199,ko04152,AMPK signaling pathway;K07199,ko04932,Non-alcoholic fatty liver disease (NAFLD);K07199,ko04921,Oxytocin signaling pathway;K07199,ko04213,Longevity regulating pathway - multiple species;K07199,ko04920,Adipocytokine signaling pathway;K07199,ko05410,Hypertrophic cardiomyopathy (HCM);K07199,ko04922,Glucagon signaling pathway;K07199,ko04710,Circadian rhythm"]
["GNA13",20.28460489,6.419738344,1.658763631,6.111176411,{"v":1.22e-10,"d":"1.22E-10"},{"v":1.36e-09,"d":"1.36E-09"},"ENSG00000120063","A0A0D9QVL0,G protein subunit alpha 13","XP_008010259.1,-","PF00503,-protein alpha subunit","IPR011025,G protein alpha subunit, helical insertion;IPR000469,G-protein alpha subunit, group 12/13;IPR001019,Guanine nucleotide binding protein (G-protein), alpha subunit;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0001664,molecular_function,G-protein coupled receptor binding;GO:0030334,biological_process,regulation of cell migration;GO:0001569,biological_process,branching involved in blood vessel morphogenesis;GO:0035556,biological_process,intracellular signal transduction;GO:0005525,molecular_function,GTP binding;GO:0007189,biological_process,adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0003924,molecular_function,GTPase activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0004871,molecular_function,signal transducer activity;GO:0030154,biological_process,cell differentiation;GO:0019001,molecular_function,guanyl nucleotide binding;GO:0001701,biological_process,in utero embryonic development;GO:0001525,biological_process,angiogenesis;GO:0030168,biological_process,platelet activation;GO:0007266,biological_process,Rho protein signal transduction;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0031683,molecular_function,G-protein beta/gamma-subunit complex binding;GO:0005829,cellular_component,cytosol;GO:0008360,biological_process,regulation of cell shape;GO:0000166,molecular_function,nucleotide binding;GO:0007165,biological_process,signal transduction","K04639,ko05200,Pathways in cancer;K04639,ko04270,Vascular smooth muscle contraction;K04639,ko04022,cGMP-PKG signaling pathway;K04639,ko04810,Regulation of actin cytoskeleton;K04639,ko04071,Sphingolipid signaling pathway;K04639,ko04072,Phospholipase D signaling pathway;K04639,ko04730,Long-term depression;K04639,ko04611,Platelet activation"]
["MED1",16.94292715,5.364203739,1.658384618,6.370501402,{"v":3.94e-11,"d":"3.94E-11"},{"v":4.92e-10,"d":"4.92E-10"},"ENSG00000125686","H2QCU3,Mediator of RNA polymerase II transcription subunit 1","XP_001172406.1,mediator of RNA polymerase II transcription subunit 1 isoform X1","PF10744,Mediator of RNA polymerase II transcription subunit 1","IPR019680,Mediator complex, subunit Med1","ENOG410XR2E,-;ENOG410IEFR,-","GO:0003712,molecular_function,transcription cofactor activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus;GO:0030331,molecular_function,estrogen receptor binding;GO:0042809,molecular_function,vitamin D receptor binding;GO:0007420,biological_process,brain development;GO:0001047,molecular_function,core promoter binding;GO:2000273,biological_process,positive regulation of signaling receptor activity;GO:0006590,biological_process,thyroid hormone generation;GO:0006367,biological_process,transcription initiation from RNA polymerase II promoter;GO:0030521,biological_process,androgen receptor signaling pathway;GO:0035257,molecular_function,nuclear hormone receptor binding;GO:0002088,biological_process,lens development in camera-type eye;GO:0002154,biological_process,thyroid hormone mediated signaling pathway;GO:0007275,biological_process,multicellular organism development;GO:0033601,biological_process,positive regulation of mammary gland epithelial cell proliferation;GO:0033160,biological_process,positive regulation of protein import into nucleus, translocation;GO:0016592,cellular_component,mediator complex;GO:0016922,molecular_function,ligand-dependent nuclear receptor binding;GO:0008134,molecular_function,transcription factor binding;GO:0033598,biological_process,mammary gland epithelial cell proliferation;GO:0009887,biological_process,animal organ morphogenesis;GO:0070562,biological_process,regulation of vitamin D receptor signaling pathway;GO:0030375,molecular_function,thyroid hormone receptor coactivator activity;GO:0042789,biological_process,mRNA transcription by RNA polymerase II;GO:0042975,molecular_function,peroxisome proliferator activated receptor binding;GO:0030224,biological_process,monocyte differentiation;GO:0003682,molecular_function,chromatin binding;GO:0045665,biological_process,negative regulation of neuron differentiation;GO:0010628,biological_process,positive regulation of gene expression;GO:0071383,biological_process,cellular response to steroid hormone stimulus;GO:0060335,biological_process,positive regulation of interferon-gamma-mediated signaling pathway;GO:0035357,biological_process,peroxisome proliferator activated receptor signaling pathway;GO:0035855,biological_process,megakaryocyte development;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0070318,biological_process,positive regulation of G0 to G1 transition;GO:0046966,molecular_function,thyroid hormone receptor binding;GO:0004872,-,-;GO:0001889,biological_process,liver development;GO:0001701,biological_process,in utero embryonic development;GO:0030216,biological_process,keratinocyte differentiation;GO:0033148,biological_process,positive regulation of intracellular estrogen receptor signaling pathway;GO:0003406,biological_process,retinal pigment epithelium development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0045444,biological_process,fat cell differentiation;GO:0031100,biological_process,animal organ regeneration;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0042974,molecular_function,retinoic acid receptor binding;GO:0000979,molecular_function,RNA polymerase II core promoter sequence-specific DNA binding;GO:0048822,biological_process,enucleate erythrocyte development;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005730,cellular_component,nucleolus;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003713,molecular_function,transcription coactivator activity;GO:0007595,biological_process,lactation;GO:0035116,biological_process,embryonic hindlimb morphogenesis;GO:0060745,biological_process,mammary gland branching involved in pregnancy;GO:0050693,molecular_function,LBD domain binding;GO:0070371,biological_process,ERK1 and ERK2 cascade;GO:0035729,biological_process,cellular response to hepatocyte growth factor stimulus;GO:0060744,biological_process,mammary gland branching involved in thelarche;GO:0006351,biological_process,transcription, DNA-templated;GO:2000347,biological_process,positive regulation of hepatocyte proliferation;GO:0010839,biological_process,negative regulation of keratinocyte proliferation;GO:2001141,biological_process,regulation of RNA biosynthetic process;GO:0035050,biological_process,embryonic heart tube development;GO:0000902,biological_process,cell morphogenesis;GO:0097067,biological_process,cellular response to thyroid hormone stimulus;GO:0006702,biological_process,androgen biosynthetic process;GO:0007507,biological_process,heart development;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0048821,biological_process,erythrocyte development;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006356,biological_process,regulation of transcription by RNA polymerase I;GO:0036033,molecular_function,mediator complex binding;GO:0003677,molecular_function,DNA binding;GO:0035162,biological_process,embryonic hemopoiesis;GO:0001525,biological_process,angiogenesis;GO:0045618,biological_process,positive regulation of keratinocyte differentiation;GO:0045648,biological_process,positive regulation of erythrocyte differentiation;GO:0005654,cellular_component,nucleoplasm;GO:0043010,biological_process,camera-type eye development;GO:0030518,biological_process,intracellular steroid hormone receptor signaling pathway;GO:0060750,biological_process,epithelial cell proliferation involved in mammary gland duct elongation;GO:0001892,biological_process,embryonic placenta development;GO:0003222,biological_process,ventricular trabecula myocardium morphogenesis","K15144,ko01522,Endocrine resistance;K15144,ko04919,Thyroid hormone signaling pathway"]
["AC008277.1",32.19532393,10.1853055,1.658160744,5.043475148,{"v":3.69E-8,"d":"3.69E-08"},{"v":2.4e-07,"d":"2.40E-07"},"-","-","-","-","-","-","-","-"]
["BCOR",4.00213728,1.265554036,1.657867857,4.549487829,{"v":9.8e-07,"d":"9.80E-07"},{"v":4.63e-06,"d":"4.63E-06"},"ENSG00000183337","H9A532,BCL6 corepressor-cyclin B3 fusion protein","-","PF12796,Ankyrin repeats (3 copies);PF15808,BCL-6 co-repressor, non-ankyrin-repeat region;PF02984,Cyclin, C-terminal domain;PF00134,Cyclin, N-terminal domain;PF16553,BCORL-PCGF1-binding domain","IPR032365,BCL-6 corepressor, PCGF1 binding domain;IPR038227,PCGF Ub-like fold discriminator superfamily;IPR036915,Cyclin-like superfamily;IPR002110,Ankyrin repeat;IPR013763,Cyclin-like;IPR006671,Cyclin, N-terminal;IPR031628,BCL-6 corepressor, non-ankyrin-repeat domain;IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR004367,Cyclin, C-terminal domain","ENOG410IHDH,-;ENOG410YT00,-","GO:0005634,cellular_component,nucleus","-"]
["DRAM2",6.280813275,1.983940553,1.657145468,3.789757162,{"v":4.93e-05,"d":"4.93E-05"},0.000160004,"ENSG00000156171","H2PZM9,DNA-damage regulated autophagy modulator 2","XP_009427815.1,-;XP_016781255.1,-;XP_016781247.1,-;XP_001162049.1,-","PF10277,rag1/DRAM/Sfk1 family","IPR019402,Frag1/DRAM/Sfk1;IPR032990,DNA damage-regulated autophagy modulator protein 2","ENOG4111KNB,-;KOG4320,Uncharacterized conserved protein","GO:0010506,biological_process,regulation of autophagy;GO:0005737,cellular_component,cytoplasm;GO:0005794,cellular_component,Golgi apparatus;GO:0005764,cellular_component,lysosome;GO:0045494,biological_process,photoreceptor cell maintenance;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016324,cellular_component,apical plasma membrane;GO:0016020,cellular_component,membrane;GO:0001917,cellular_component,photoreceptor inner segment;GO:0007601,biological_process,visual perception;GO:0016021,cellular_component,integral component of membrane","-"]
["PIK3C2B",4.288105449,1.35743301,1.656808259,4.781338578,{"v":2.12e-07,"d":"2.12E-07"},{"v":1.16e-06,"d":"1.16E-06"},"ENSG00000133056","A2RUF7,Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta","XP_005245314.1,-;XP_016856963.1,-;NP_002637.3,phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta;XP_011507932.1,-;XP_011507933.1,-;XP_016856962.1,-","PF00792,Phosphoinositide 3-kinase C2;PF00787,PX domain;PF00454,Phosphatidylinositol 3- and 4-kinase;PF00613,Phosphoinositide 3-kinase family, accessory domain (PIK domain);PF00168,C2 domain;PF00794,PI3-kinase family, ras-binding domain","IPR018936,Phosphatidylinositol 3/4-kinase, conserved site;IPR000341,Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain;IPR036871,PX domain superfamily;IPR000403,Phosphatidylinositol 3-/4-kinase, catalytic domain;IPR015433,Phosphatidylinositol kinase;IPR036940,Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily;IPR016024,Armadillo-type fold;IPR011009,Protein kinase-like domain superfamily;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR001683,Phox homologous domain;IPR029071,Ubiquitin-like domain superfamily;IPR001263,Phosphoinositide 3-kinase, accessory (PIK) domain;IPR002420,Phosphatidylinositol 3-kinase, C2 domain","KOG0905,Phosphoinositide 3-kinase;COG5032,Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family","GO:0001727,molecular_function,lipid kinase activity;GO:0016301,molecular_function,kinase activity;GO:0048015,biological_process,phosphatidylinositol-mediated signaling;GO:0016236,biological_process,macroautophagy;GO:1905037,biological_process,autophagosome organization;GO:0043491,biological_process,protein kinase B signaling;GO:0036092,biological_process,phosphatidylinositol-3-phosphate biosynthetic process;GO:0009267,biological_process,cellular response to starvation;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0016740,molecular_function,transferase activity;GO:0005829,cellular_component,cytosol;GO:0030139,cellular_component,endocytic vesicle;GO:0016310,biological_process,phosphorylation;GO:0046854,biological_process,phosphatidylinositol phosphorylation;GO:0005654,cellular_component,nucleoplasm","K00923,ko04070,Phosphatidylinositol signaling system;K00923,ko00562,Inositol phosphate metabolism"]
["CIAO1",10.01444423,3.170149928,1.656808259,4.781338578,{"v":2.12e-07,"d":"2.12E-07"},{"v":1.16e-06,"d":"1.16E-06"},"ENSG00000144021","A0A0D9RXR6,Probable cytosolic iron-sulfur protein assembly protein CIAO1","XP_008006159.1,-","PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR028608,Probable cytosolic iron-sulfur protein assembly protein, CIAO1/Cia1;IPR001680,WD40 repeat","-","GO:0097361,cellular_component,CIA complex;GO:0007059,biological_process,chromosome segregation;GO:0016226,biological_process,iron-sulfur cluster assembly;GO:0071817,cellular_component,MMXD complex","-"]
["RBM33",10.9399473,3.468262174,1.656576647,6.578818255,1.45E-11,2.02E-10,"ENSG00000184863","H2QVN7,Uncharacterized protein","XP_009442492.1,-","-","IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily","ENOG410IG08,-;ENOG410XTRH,-","GO:0003676,molecular_function,nucleic acid binding","-"]
["ZC3H7B",6.971514004,2.210366233,1.655730225,5.622981375,{"v":1.76e-09,"d":"1.76E-09"},{"v":1.53e-08,"d":"1.53E-08"},"ENSG00000100403","K7D838,Zinc finger CCCH-type containing 7B","-","PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar);PF13181,Tetratricopeptide repeat","IPR036236,Zinc finger C2H2 superfamily;IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR036855,Zinc finger, CCCH-type superfamily;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR000571,Zinc finger, CCCH-type","ENOG410IN1T,-;ENOG410YBKB,-","GO:0046872,molecular_function,metal ion binding","-"]
["PUM1",47.09034447,14.94553095,1.655374646,7.689110393,{"v":3.03e-13,"d":"3.03E-13"},{"v":6.27e-12,"d":"6.27E-12"},"ENSG00000134644","Q5T1Z8,Pumilio homolog 1","-","PF00806,Pumilio-family RNA binding repeat","IPR016024,Armadillo-type fold;IPR033712,Pumilio, RNA binding domain;IPR011989,Armadillo-like helical;IPR001313,Pumilio RNA-binding repeat;IPR033133,Pumilio homology domain","COG5099,RNA-binding protein of the Puf family, translational repressor;KOG1488,Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily)","GO:0003723,molecular_function,RNA binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0016607,cellular_component,nuclear speck;GO:0005654,cellular_component,nucleoplasm","-"]
["IL6R",4.967785466,1.574084425,1.654757658,4.460418302,{"v":1.1e-06,"d":"1.10E-06"},{"v":5.13E-6,"d":"5.13E-06"},"ENSG00000160712","A0N0L5,Interleukin 6 receptor","NP_000556.1,interleukin-6 receptor subunit alpha isoform 1 precursor","PF09240,Interleukin-6 receptor alpha chain, binding;PF00047,Immunoglobulin domain","IPR003961,Fibronectin type III;IPR013151,Immunoglobulin;IPR036116,Fibronectin type III superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003530,Long hematopoietin receptor, soluble alpha chain, conserved site;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR007110,Immunoglobulin-like domain;IPR015321,Type I cytokine receptor, cytokine-binding domain","ENOG4111XGC,-;ENOG410II5K,-","GO:0004896,molecular_function,cytokine receptor activity;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K05055,ko04060,Cytokine-cytokine receptor interaction;K05055,ko01521,EGFR tyrosine kinase inhibitor resistance;K05055,ko04640,Hematopoietic cell lineage;K05055,ko04630,Jak-STAT signaling pathway;K05055,ko04066,HIF-1 signaling pathway;K05055,ko04932,Non-alcoholic fatty liver disease (NAFLD);K05055,ko04151,PI3K-Akt signaling pathway"]
["MKNK2",42.47994172,13.49313172,1.654075715,7.2008013,1.52E-12,{"v":2.64e-11,"d":"2.64E-11"},"ENSG00000099875","A4CYL7,Putative map kinase interacting kinase [Homo sapiens]","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XQA9,-;KOG0607,MAP kinase-interacting kinase and related serine/threonine protein kinases","GO:0016301,molecular_function,kinase activity;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0004672,molecular_function,protein kinase activity","-"]
["BFAR",9.388335669,2.978081755,1.653903579,4.814527056,{"v":1.83e-07,"d":"1.83E-07"},{"v":1.02E-6,"d":"1.02E-06"},"ENSG00000103429","B2R9R6,cDNA, FLJ94525, highly similar to Homo sapiens bifunctional apoptosis regulator","-","PF15227,zinc finger of C3HC4-type, RING;PF00536,SAM domain (Sterile alpha motif)","IPR017907,Zinc finger, RING-type, conserved site;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","KOG4159,Predicted E3 ubiquitin ligase;COG2802,Uncharacterized protein, similar to the N-terminal domain of Lon protease","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CSNK1D",21.32488605,6.776783879,1.653412035,7.284428206,{"v":1.1E-12,"d":"1.10E-12"},{"v":1.98e-11,"d":"1.98E-11"},"ENSG00000141551","A0A096NTN2,Casein kinase 1 delta","XP_009189799.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:0061512,biological_process,protein localization to cilium;GO:0005524,molecular_function,ATP binding;GO:2000052,biological_process,positive regulation of non-canonical Wnt signaling pathway;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0005794,cellular_component,Golgi apparatus;GO:0032922,biological_process,circadian regulation of gene expression;GO:0032436,biological_process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034067,biological_process,protein localization to Golgi apparatus;GO:0030177,biological_process,positive regulation of Wnt signaling pathway;GO:1905515,biological_process,non-motile cilium assembly;GO:0005813,cellular_component,centrosome;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0071539,biological_process,protein localization to centrosome;GO:0005634,cellular_component,nucleus;GO:0051225,biological_process,spindle assembly;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0007020,biological_process,microtubule nucleation;GO:0005819,cellular_component,spindle;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0007030,biological_process,Golgi organization;GO:0005876,cellular_component,spindle microtubule;GO:0045296,molecular_function,cadherin binding;GO:0042752,biological_process,regulation of circadian rhythm;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway;GO:0001934,biological_process,positive regulation of protein phosphorylation","-"]
["ICE1",6.184142986,1.96341313,1.653223406,5.181768189,{"v":1.86e-08,"d":"1.86E-08"},{"v":1.29E-7,"d":"1.29E-07"},"ENSG00000164151","K7CR63,KIAA0947","-","-","-","ENOG410IE47,-;ENOG4111F6B,-","-","-"]
["RP11-359B12.2",1.423854782,0.446529634,1.652452144,2.052067084,0.021143814,0.036905358,"ENSG00000250132","G7MPF7,Uncharacterized protein","-","-","-","-","-","-"]
["C17orf97",1.927720737,0.604545102,1.652452144,2.052067084,0.021143814,0.036905358,"ENSG00000187624","A0A0H4IV28,CK20","NP_001013694.4,protein LIAT1","-","-","-","-","-"]
["DNAJC30",2.102262856,0.659282586,1.652452144,2.052067084,0.021143814,0.036905358,"ENSG00000176410","K7DIR8,DnaJ","-","PF00226,naJ domain","IPR036869,Chaperone J-domain superfamily;IPR001623,DnaJ domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["OTUD3",1.228181629,0.387366272,1.65189554,2.639894302,5.100126E-3,0.010435643,"ENSG00000169914","H2PY75,OTU deubiquitinase 3","-","PF02338,OTU-like cysteine protease","IPR003323,OTU domain","ENOG4110S6T,-;ENOG410IERN,-","GO:0071108,biological_process,protein K48-linked deubiquitination;GO:0050821,biological_process,protein stabilization;GO:0051898,biological_process,negative regulation of protein kinase B signaling;GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0035871,biological_process,protein K11-linked deubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0044313,biological_process,protein K6-linked deubiquitination;GO:1990167,biological_process,protein K27-linked deubiquitination","-"]
["NPIPA1",1.142105962,0.360218161,1.65189554,2.639894302,5.100126E-3,0.010435643,"ENSG00000183426","A0A067ZUL9,Nuclear pore complex-interacting protein A type","-","PF06409,Nuclear pore complex interacting protein (NPIP)","IPR009443,Nuclear pore complex interacting protein","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);ENOG410J0WZ,-","-","-"]
["PXK",1.552316975,0.489597975,1.65189554,2.639894302,5.100126E-3,0.010435643,"ENSG00000168297","H9ET08,PX domain containing serine/threonine kinase like","XP_014986092.1,PX domain-containing protein kinase-like protein isoform X1","PF00069,Protein kinase domain;PF02205,WH2 motif;PF00787,PX domain","IPR037903,MONaKA, PX domain;IPR036871,PX domain superfamily;IPR003124,WH2 domain;IPR011009,Protein kinase-like domain superfamily;IPR001683,Phox homologous domain;IPR000719,Protein kinase domain","-","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0003779,molecular_function,actin binding;GO:0005524,molecular_function,ATP binding;GO:0005815,cellular_component,microtubule organizing center;GO:0005886,cellular_component,plasma membrane;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0016310,biological_process,phosphorylation;GO:0006954,biological_process,inflammatory response","-"]
["FAM219A",2.197542328,0.693100889,1.65189554,2.639894302,5.100126E-3,0.010435643,"ENSG00000164970","G1QYD8,Family with sequence similarity 219 member A","-","PF15260,Protein family FAM219A","IPR029339,Protein FAM219","ENOG410Y14P,-;ENOG410IVPC,-","-","-"]
["YEATS2",14.02158907,4.459970512,1.651800653,6.575213535,{"v":1.71e-11,"d":"1.71E-11"},{"v":2.34e-10,"d":"2.34E-10"},"ENSG00000163872","H2QNT9,YEATS domain containing 2","XP_001135033.5,-","PF03366,YEATS family","IPR038704,YEATS superfamily;IPR005033,YEATS","KOG3149,Transcription initiation factor IIF, auxiliary subunit;COG5033,Transcription initiation factor IIF, auxiliary subunit","GO:0140030,molecular_function,modification-dependent protein binding;GO:0043966,biological_process,histone H3 acetylation;GO:0005671,cellular_component,Ada2/Gcn5/Ada3 transcription activator complex;GO:0042393,molecular_function,histone binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0017025,molecular_function,TBP-class protein binding;GO:0072686,cellular_component,mitotic spindle;GO:0005634,cellular_component,nucleus;GO:0045892,biological_process,negative regulation of transcription, DNA-templated","-"]
["BMP4",3.698276111,1.169467195,1.651639594,3.053771401,0.00108952,0.002610728,"ENSG00000125378","Q53XC5,Bone morphogenetic protein 4","NP_570912.2,-;NP_001334845.1,-;NP_570911.2,-;NP_001334843.1,-;NP_001193.2,bone morphogenetic protein 4 isoform a preproprotein","PF00019,Transforming growth factor beta like domain;PF00688,TGF-beta propeptide","IPR001839,Transforming growth factor-beta, C-terminal;IPR015615,Transforming growth factor-beta-related;IPR017948,Transforming growth factor beta, conserved site;IPR029034,Cystine-knot cytokine;IPR001111,TGF-beta, propeptide","ENOG410XT8Z,-;KOG3900,Transforming growth factor beta, bone morphogenetic protein and related proteins","GO:0021983,biological_process,pituitary gland development;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0010159,biological_process,specification of animal organ position;GO:0048646,biological_process,anatomical structure formation involved in morphogenesis;GO:0051145,biological_process,smooth muscle cell differentiation;GO:0030900,biological_process,forebrain development;GO:0005576,cellular_component,extracellular region;GO:0061626,biological_process,pharyngeal arch artery morphogenesis;GO:0072001,biological_process,renal system development;GO:0060449,biological_process,bud elongation involved in lung branching;GO:0060976,biological_process,coronary vasculature development;GO:0001759,biological_process,organ induction;GO:0001501,biological_process,skeletal system development;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0001657,biological_process,ureteric bud development;GO:0060235,biological_process,lens induction in camera-type eye;GO:0048704,biological_process,embryonic skeletal system morphogenesis;GO:0042475,biological_process,odontogenesis of dentin-containing tooth;GO:0001938,biological_process,positive regulation of endothelial cell proliferation;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0001822,biological_process,kidney development;GO:0055007,biological_process,cardiac muscle cell differentiation;GO:0030335,biological_process,positive regulation of cell migration;GO:0048706,biological_process,embryonic skeletal system development;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0072198,biological_process,mesenchymal cell proliferation involved in ureter development;GO:0060592,biological_process,mammary gland formation;GO:0060272,biological_process,embryonic skeletal joint morphogenesis;GO:0090191,biological_process,negative regulation of branching involved in ureteric bud morphogenesis;GO:0060348,biological_process,bone development;GO:0060440,biological_process,trachea formation;GO:0061151,biological_process,BMP signaling pathway involved in renal system segmentation;GO:0072161,biological_process,mesenchymal cell differentiation involved in kidney development;GO:0045603,biological_process,positive regulation of endothelial cell differentiation;GO:0060684,biological_process,epithelial-mesenchymal cell signaling;GO:0060687,biological_process,regulation of branching involved in prostate gland morphogenesis;GO:1902895,biological_process,positive regulation of pri-miRNA transcription by RNA polymerase II;GO:0051150,biological_process,regulation of smooth muscle cell differentiation;GO:0072205,biological_process,metanephric collecting duct development;GO:0035993,biological_process,deltoid tuberosity development;GO:0003014,biological_process,renal system process;GO:0005615,cellular_component,extracellular space;GO:0060686,biological_process,negative regulation of prostatic bud formation;GO:0021904,biological_process,dorsal/ventral neural tube patterning;GO:0010629,biological_process,negative regulation of gene expression;GO:0003148,biological_process,outflow tract septum morphogenesis;GO:0001843,biological_process,neural tube closure;GO:0001958,biological_process,endochondral ossification;GO:0060113,biological_process,inner ear receptor cell differentiation;GO:0048660,biological_process,regulation of smooth muscle cell proliferation;GO:0010628,biological_process,positive regulation of gene expression;GO:0060395,biological_process,SMAD protein signal transduction;GO:0045165,biological_process,cell fate commitment;GO:0021978,biological_process,telencephalon regionalization;GO:0060429,biological_process,epithelium development;GO:0007500,biological_process,mesodermal cell fate determination;GO:0072193,biological_process,ureter smooth muscle cell differentiation;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0042733,biological_process,embryonic digit morphogenesis;GO:0061149,biological_process,BMP signaling pathway involved in ureter morphogenesis;GO:0060363,biological_process,cranial suture morphogenesis;GO:0001944,biological_process,vasculature development;GO:0001525,biological_process,angiogenesis;GO:0003149,biological_process,membranous septum morphogenesis;GO:2001237,biological_process,negative regulation of extrinsic apoptotic signaling pathway;GO:0001934,biological_process,positive regulation of protein phosphorylation;GO:0035990,biological_process,tendon cell differentiation;GO:0008083,molecular_function,growth factor activity;GO:0009948,biological_process,anterior/posterior axis specification;GO:0003197,biological_process,endocardial cushion development;GO:0010468,biological_process,regulation of gene expression;GO:0048333,biological_process,mesodermal cell differentiation;GO:0001649,biological_process,osteoblast differentiation;GO:0007281,biological_process,germ cell development;GO:0032331,biological_process,negative regulation of chondrocyte differentiation;GO:0060197,biological_process,cloacal septation;GO:0060442,biological_process,branching involved in prostate gland morphogenesis;GO:0001707,biological_process,mesoderm formation;GO:0003184,biological_process,pulmonary valve morphogenesis;GO:0045778,biological_process,positive regulation of ossification;GO:0048598,biological_process,embryonic morphogenesis;GO:0001656,biological_process,metanephros development;GO:0030509,biological_process,BMP signaling pathway;GO:0061035,biological_process,regulation of cartilage development;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0002062,biological_process,chondrocyte differentiation;GO:0030324,biological_process,lung development;GO:0042487,biological_process,regulation of odontogenesis of dentin-containing tooth;GO:0003151,biological_process,outflow tract morphogenesis;GO:1901964,biological_process,positive regulation of cell proliferation involved in outflow tract morphogenesis;GO:0009888,biological_process,tissue development;GO:0048701,biological_process,embryonic cranial skeleton morphogenesis;GO:0035116,biological_process,embryonic hindlimb morphogenesis;GO:0072138,biological_process,mesenchymal cell proliferation involved in ureteric bud development;GO:0050680,biological_process,negative regulation of epithelial cell proliferation;GO:1905312,biological_process,positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis;GO:0048593,biological_process,camera-type eye morphogenesis;GO:0030218,biological_process,erythrocyte differentiation;GO:0060512,biological_process,prostate gland morphogenesis;GO:0007507,biological_process,heart development;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0008201,molecular_function,heparin binding;GO:0072104,biological_process,glomerular capillary formation;GO:0001658,biological_process,branching involved in ureteric bud morphogenesis;GO:0045597,biological_process,positive regulation of cell differentiation;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0072192,biological_process,ureter epithelial cell differentiation;GO:0045595,biological_process,regulation of cell differentiation;GO:0048745,biological_process,smooth muscle tissue development;GO:0003180,biological_process,aortic valve morphogenesis;GO:2001012,biological_process,mesenchymal cell differentiation involved in renal system development;GO:0007492,biological_process,endoderm development;GO:0009791,biological_process,post-embryonic development;GO:0061047,biological_process,positive regulation of branching involved in lung morphogenesis;GO:0061312,biological_process,BMP signaling pathway involved in heart development;GO:0043010,biological_process,camera-type eye development;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0071363,biological_process,cellular response to growth factor stimulus;GO:0048663,biological_process,neuron fate commitment;GO:0060688,biological_process,regulation of morphogenesis of a branching structure;GO:0001568,biological_process,blood vessel development;GO:0072015,biological_process,glomerular visceral epithelial cell development;GO:0030513,biological_process,positive regulation of BMP signaling pathway","K04662,ko04060,Cytokine-cytokine receptor interaction;K04662,ko04350,TGF-beta signaling pathway;K04662,ko04341,Hedgehog signaling pathway - fly;K04662,ko04013,MAPK signaling pathway - fly;K04662,ko05217,Basal cell carcinoma;K04662,ko05200,Pathways in cancer;K04662,ko04390,Hippo signaling pathway;K04662,ko04550,Signaling pathways regulating pluripotency of stem cells"]
["AC017101.10",19.96162342,6.312255509,1.651639594,3.053771401,0.00108952,0.002610728,"ENSG00000227227","G3QQK9,Integrin subunit alpha V","-","PF01839,-GAP repeat;PF08441,Integrin alpha;PF00357,Integrin alpha cytoplasmic region","IPR013517,FG-GAP repeat;IPR018184,Integrin alpha chain, C-terminal cytoplasmic region, conserved site;IPR032695,Integrin domain superfamily;IPR013649,Integrin alpha-2;IPR013519,Integrin alpha beta-propellor;IPR000413,Integrin alpha chain;IPR028994,Integrin alpha, N-terminal","-","GO:0008305,cellular_component,integrin complex;GO:0007155,biological_process,cell adhesion;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ABHD4",3.558984978,1.127097845,1.651492501,3.373732156,2.14124E-4,0.000602642,"ENSG00000100439","H2Q7Z0,Abhydrolase domain containing 4","XP_016781346.1,-","PF12697,Alpha/beta hydrolase family;PF00561,alpha/beta hydrolase fold;PF12146,Serine aminopeptidase, S33","IPR000073,Alpha/beta hydrolase fold-1;IPR029058,Alpha/Beta hydrolase fold","KOG4409,Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily);COG0596,Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)","GO:0016787,molecular_function,hydrolase activity","-"]
["RP11-57A1.1",21.09489886,6.687009083,1.651396997,3.634754717,{"v":8.61e-05,"d":"8.61E-05"},0.000263617,"-","-","-","-","-","-","-","-"]
["GAS2L3",3.038539879,0.963857759,1.651329991,3.855291411,{"v":3.79E-5,"d":"3.79E-05"},0.000126355,"ENSG00000139354","A0A024RBF4,Growth arrest-specific 2 like 3, isoform CRA_a","XP_016874695.1,-;NP_777602.1,GAS2-like protein 3 isoform a;XP_011536522.1,-;XP_011536521.1,-;NP_001290059.1,-;XP_005268861.1,-;XP_011536523.1,-","PF02187,rowth-Arrest-Specific Protein 2 Domain;PF00307,Calponin homology (CH) domain","IPR003108,GAR domain;IPR036534,GAR domain superfamily;IPR029932,GAS2-like protein 3;IPR036872,CH domain superfamily;IPR001715,Calponin homology domain","ENOG410IQBS,-;ENOG410Z7C5,-","GO:0005856,cellular_component,cytoskeleton;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0008017,molecular_function,microtubule binding;GO:0003779,molecular_function,actin binding;GO:0030036,biological_process,actin cytoskeleton organization","-"]
["SMAGP",6.673978226,2.118116705,1.651280383,4.046278562,{"v":8.47e-06,"d":"8.47E-06"},{"v":3.27e-05,"d":"3.27E-05"},"ENSG00000170545","G1S7U6,Small cell adhesion glycoprotein","XP_012363855.1,small cell adhesion glycoprotein","-","-","ENOG410J3FG,-;ENOG410ZCM8,-","GO:0030054,cellular_component,cell junction;GO:0016020,cellular_component,membrane;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["EXOC8",5.261371846,1.670441093,1.651242175,4.214736632,{"v":4.47e-06,"d":"4.47E-06"},{"v":1.84E-5,"d":"1.84E-05"},"ENSG00000116903","K7CAG4,Exocyst complex component 8","-","PF16528,xocyst component 84 C-terminal;PF08700,Vps51/Vps67","IPR033961,Exocyst complex component Exo84;IPR016159,Cullin repeat-like-containing domain superfamily;IPR032403,Exocyst component Exo84, C-terminal;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","ENOG410XT7U,-;KOG2215,Exocyst complex subunit","GO:0000145,cellular_component,exocyst;GO:0006887,biological_process,exocytosis","-"]
["ETHE1",18.65335306,5.924089718,1.651211844,4.365443256,{"v":2.48E-6,"d":"2.48E-06"},{"v":1.08E-5,"d":"1.08E-05"},"ENSG00000105755","M0QXB5,Persulfide dioxygenase ETHE1, mitochondrial","-","PF00753,Metallo-beta-lactamase superfamily","IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR001279,Metallo-beta-lactamase","KOG0814,Glyoxylase;COG0491,Zn-dependent hydrolases, including glyoxylases","GO:0005739,cellular_component,mitochondrion;GO:0005654,cellular_component,nucleoplasm","-"]
["LA16c-306E5.2",12.33559196,3.921614953,1.651110983,5.038203016,{"v":4.4e-08,"d":"4.40E-08"},{"v":2.8e-07,"d":"2.80E-07"},"ENSG00000262621","A0A0B4J2C4,Uncharacterized protein","-","-","-","-","-","-"]
["SRP68",27.34785079,8.705101342,1.65098571,7.116196714,{"v":2.29e-12,"d":"2.29E-12"},{"v":3.78e-11,"d":"3.78E-11"},"ENSG00000167881","A0A0D9QY64,Signal recognition particle subunit SRP68","-","PF16969,RNA-binding signal recognition particle 68","IPR034652,Signal recognition particle subunit SRP68, RNA-binding domain;IPR038253,SRP68, N-terminal domain superfamily;IPR026258,Signal recognition particle subunit SRP68","-","GO:0003723,molecular_function,RNA binding;GO:0006614,biological_process,SRP-dependent cotranslational protein targeting to membrane;GO:0005047,molecular_function,signal recognition particle binding;GO:0005786,cellular_component,signal recognition particle, endoplasmic reticulum targeting;GO:0030942,molecular_function,endoplasmic reticulum signal peptide binding;GO:0043022,molecular_function,ribosome binding;GO:0019904,molecular_function,protein domain specific binding;GO:0005737,cellular_component,cytoplasm;GO:0008312,molecular_function,7S RNA binding;GO:0030529,,;GO:0048500,cellular_component,signal recognition particle;GO:0005829,cellular_component,cytosol;GO:0005925,cellular_component,focal adhesion;GO:0042493,biological_process,response to drug","-"]
["LAMB2",7.194713797,2.29101899,1.648799039,5.06601537,{"v":5.76E-8,"d":"5.76E-08"},{"v":3.58E-7,"d":"3.58E-07"},"ENSG00000172037","A0A024R319,Laminin, beta 2","XP_005265184.1,-;NP_002283.3,laminin subunit beta-2 precursor","PF00055,Laminin N-terminal (Domain VI);PF00053,Laminin EGF domain","IPR008211,Laminin, N-terminal;IPR002049,Laminin EGF domain;IPR013015,Laminin IV type B;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR038684,Laminin, N-terminal domain superfamily","KOG0994,Extracellular matrix glycoprotein Laminin subunit beta;ENOG410XPEG,-","GO:0005178,molecular_function,integrin binding;GO:0072274,biological_process,metanephric glomerular basement membrane development;GO:0014044,biological_process,Schwann cell development;GO:0000904,biological_process,cell morphogenesis involved in differentiation;GO:0007528,biological_process,neuromuscular junction development;GO:0048677,biological_process,axon extension involved in regeneration;GO:0007411,biological_process,axon guidance;GO:0005604,cellular_component,basement membrane;GO:0005608,cellular_component,laminin-3 complex;GO:0043083,cellular_component,synaptic cleft;GO:0050808,biological_process,synapse organization;GO:0043256,cellular_component,laminin complex;GO:0014002,biological_process,astrocyte development;GO:0005605,cellular_component,basal lamina;GO:0045202,cellular_component,synapse;GO:0031175,biological_process,neuron projection development;GO:0007601,biological_process,visual perception;GO:0060041,biological_process,retina development in camera-type eye;GO:0072249,biological_process,metanephric glomerular visceral epithelial cell development;GO:0005615,cellular_component,extracellular space","K06243,ko05146,Amoebiasis;K06243,ko05222,Small cell lung cancer;K06243,ko05145,Toxoplasmosis;K06243,ko04512,ECM-receptor interaction;K06243,ko04510,Focal adhesion;K06243,ko04151,PI3K-Akt signaling pathway;K06243,ko05200,Pathways in cancer"]
["ZFYVE16",2.962813086,0.943451155,1.647824338,4.54201915,{"v":1.21e-06,"d":"1.21E-06"},{"v":5.61e-06,"d":"5.61E-06"},"ENSG00000039319","A0A024RAL3,Zinc finger, FYVE domain containing 16, isoform CRA_a","-","PF01363,YVE zinc finger;PF11979,omain of unknown function (DUF3480)","IPR017455,Zinc finger, FYVE-related;IPR011011,Zinc finger, FYVE/PHD-type;IPR000306,FYVE zinc finger;IPR022557,Domain of unknown function DUF3480;IPR017165,Zinc finger FYVE domain-containing protein, endofin;IPR035438,Zinc finger FYVE domain containing protein, SARA/endofin;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XSEQ,-;KOG1841,Smad anchor for receptor activation","GO:0046872,molecular_function,metal ion binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005769,cellular_component,early endosome;GO:0005829,cellular_component,cytosol;GO:0031901,cellular_component,early endosome membrane;GO:0005545,molecular_function,1-phosphatidylinositol binding","-"]
["LNPEP",6.859683222,2.189288052,1.646669249,6.130235932,1.79E-10,{"v":1.94e-09,"d":"1.94E-09"},"ENSG00000113441","B2RAK1,cDNA, FLJ94965, highly similar to Homo sapiens leucyl/cystinyl aminopeptidase","-","PF01433,Peptidase family M1 domain;PF11838,RAP1-like C-terminal domain","IPR014782,Peptidase M1, membrane alanine aminopeptidase, N-terminal;IPR001930,Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase;IPR034017,Cystinyl aminopeptidase;IPR034016,Aminopeptidase N-type;IPR024571,ERAP1-like C-terminal domain","KOG1046,Puromycin-sensitive aminopeptidase and related aminopeptidases;COG0308,Aminopeptidase N","GO:0006508,biological_process,proteolysis;GO:0008237,molecular_function,metallopeptidase activity;GO:0004177,molecular_function,aminopeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0008270,molecular_function,zinc ion binding","-"]
["NDUFB4",13.0735072,4.163008302,1.646656377,4.101258609,{"v":1.12e-05,"d":"1.12E-05"},{"v":4.21E-5,"d":"4.21E-05"},"ENSG00000065518","G3RDH1,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4","-","PF07225,NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)","-","-","-","-"]
["ZBTB33",8.894140582,2.836912944,1.646292955,5.004444206,{"v":7.06e-08,"d":"7.06E-08"},{"v":4.29e-07,"d":"4.29E-07"},"ENSG00000177485","H2R4K5,Zinc finger and BTB domain containing 33","XP_003317706.1,-;XP_521239.2,transcriptional regulator Kaiso","PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0005730,cellular_component,nucleolus;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0005886,cellular_component,plasma membrane;GO:0008327,molecular_function,methyl-CpG binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["SPATA20",4.048880124,1.289288429,1.646045319,3.917954553,{"v":2.27E-5,"d":"2.27E-05"},{"v":7.98e-05,"d":"7.98E-05"},"ENSG00000006282","K7AN05,Spermatogenesis associated 20","XP_511882.2,spermatogenesis-associated protein 20 isoform X1","PF07221,N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase);PF03190,Protein of unknown function, DUF255","IPR012341,Six-hairpin glycosidase-like superfamily;IPR004879,Domain of unknown function DUF255;IPR008928,Six-hairpin glycosidase superfamily;IPR024705,Spermatogenesis-associated protein 20;IPR036249,Thioredoxin-like superfamily","COG1331,Highly conserved protein containing a thioredoxin domain;KOG2244,Highly conserved protein containing a thioredoxin domain","GO:0003824,molecular_function,catalytic activity","-"]
["RNASEH2B",2.069022714,0.658840707,1.645231355,3.707617251,{"v":4.94e-05,"d":"4.94E-05"},0.000160102,"ENSG00000136104","G3QFF7,Ribonuclease H2 subunit B","XP_004054576.1,ribonuclease H2 subunit B isoform X1","PF09468,Ydr279p protein family (RNase H2 complex component)","IPR019024,Ribonuclease H2, subunit B","-","GO:0010389,biological_process,regulation of G2/M transition of mitotic cell cycle;GO:0048146,biological_process,positive regulation of fibroblast proliferation;GO:0004523,molecular_function,RNA-DNA hybrid ribonuclease activity;GO:0006401,biological_process,RNA catabolic process;GO:0032299,cellular_component,ribonuclease H2 complex;GO:0001701,biological_process,in utero embryonic development;GO:0010629,biological_process,negative regulation of gene expression;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0009259,biological_process,ribonucleotide metabolic process;GO:2000001,biological_process,regulation of DNA damage checkpoint;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K10744,ko03030,DNA replication"]
["HGS",17.75053424,5.676747352,1.644005484,6.609844037,{"v":1.9e-11,"d":"1.90E-11"},{"v":2.58e-10,"d":"2.58E-10"},"ENSG00000185359","A0A0S2Z4R4,Hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1","NP_004703.1,hepatocyte growth factor-regulated tyrosine kinase substrate","PF12210,Hepatocyte growth factor-regulated tyrosine kinase substrate;PF00790,VHS domain;PF01363,YVE zinc finger","IPR017455,Zinc finger, FYVE-related;IPR011011,Zinc finger, FYVE/PHD-type;IPR008942,ENTH/VHS;IPR000306,FYVE zinc finger;IPR002014,VHS domain;IPR003903,Ubiquitin interacting motif;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR024641,Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain;IPR017073,Ubiquitin binding protein, Hrs/VPS27","-","GO:0016301,molecular_function,kinase activity;GO:0005768,cellular_component,endosome;GO:0005764,cellular_component,lysosome;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0046872,molecular_function,metal ion binding;GO:0005829,cellular_component,cytosol;GO:0016310,biological_process,phosphorylation;GO:0006886,biological_process,intracellular protein transport","K12182,ko04145,Phagosome;K12182,ko04144,Endocytosis"]
["FAF2",38.52645286,12.32727775,1.643535174,7.251598705,1.52E-12,{"v":2.64e-11,"d":"2.64E-11"},"ENSG00000113194","H2PHG4,Fas associated factor family member 2","XP_002816290.1,-","PF00789,UBX domain;PF14555,UBA-like domain","IPR036249,Thioredoxin-like superfamily;IPR001012,UBX domain;IPR029071,Ubiquitin-like domain superfamily;IPR006577,UAS;IPR009060,UBA-like superfamily","KOG1363,Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains);ENOG410XSFS,-","GO:0005811,cellular_component,lipid droplet;GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0034098,cellular_component,VCP-NPL4-UFD1 AAA ATPase complex;GO:0005783,cellular_component,endoplasmic reticulum;GO:0043086,biological_process,negative regulation of catalytic activity;GO:0030970,biological_process,retrograde protein transport, ER to cytosol;GO:0055102,molecular_function,lipase inhibitor activity;GO:0043130,molecular_function,ubiquitin binding;GO:0035473,molecular_function,lipase binding;GO:0034389,biological_process,lipid particle organization","-"]
["SNX19",3.524616975,1.125438722,1.643303778,4.311084047,{"v":2.35e-06,"d":"2.35E-06"},{"v":1.03E-5,"d":"1.03E-05"},"ENSG00000120451","A8K8U2,cDNA FLJ76442","-","PF02194,PXA domain;PF08628,Sorting nexin C terminal;PF00787,PX domain","IPR013937,Sorting nexin, C-terminal;IPR034908,Sorting nexin-19;IPR036871,PX domain superfamily;IPR037909,SNX19, PX domain;IPR003114,Phox-associated domain;IPR001683,Phox homologous domain","ENOG410IH51,-;ENOG410XTBC,-","GO:0035091,molecular_function,phosphatidylinositol binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TRIM29",5.414779199,1.731633004,1.642862752,5.227104318,{"v":2.19e-08,"d":"2.19E-08"},{"v":1.49E-7,"d":"1.49E-07"},"ENSG00000137699","A0A024R3J1,Tripartite motif-containing 29, isoform CRA_a","NP_036233.2,tripartite motif-containing protein 29 isoform 1","PF00643,B-box zinc finger","IPR000315,B-box-type zinc finger","ENOG410YEFV,-;ENOG410IK88,-","GO:1900181,biological_process,negative regulation of protein localization to nucleus;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005737,cellular_component,cytoplasm;GO:0005622,cellular_component,intracellular;GO:0002039,molecular_function,p53 binding;GO:0008270,molecular_function,zinc ion binding","-"]
["RP11-472I20.4",4.156151987,1.323447102,1.642389478,3.161985902,0.000764908,0.001894669,"ENSG00000283341","G7Q268,Uncharacterized protein","-","-","-","-","-","-"]
["NEU3",1.634188401,0.520376038,1.642389478,3.161985902,0.000764908,0.001894669,"ENSG00000162139","A0A024R5N6,Sialidase 3","NP_006647.3,sialidase-3","PF13088,BNR repeat-like domain","IPR026856,Sialidase family;IPR026944,Sialidase-3;IPR036278,Sialidase superfamily;IPR011040,Sialidase","ENOG410Y74Z,-;ENOG410IFVF,-","GO:0004308,molecular_function,exo-alpha-sialidase activity","K12357,ko00511,Other glycan degradation;K12357,ko00600,Sphingolipid metabolism"]
["PDP1",18.81711663,6.023440093,1.642386292,6.140894254,1.71E-10,{"v":1.85E-9,"d":"1.85E-09"},"ENSG00000164951","G3RSN2,Pyruvate dehyrogenase phosphatase catalytic subunit 1","-","PF00481,Protein phosphatase 2C","-","-","-","-"]
["MYO1C",16.80747103,5.38602817,1.641040824,6.514813792,2.82E-11,{"v":3.67e-10,"d":"3.67E-10"},"ENSG00000197879","H2NS48,Myosin IC","-","PF06017,Unconventional myosin tail, actin- and lipid-binding;PF00063,Myosin head (motor domain);PF00612,IQ calmodulin-binding motif","IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036072,Class I myosin, motor domain;IPR010926,Class I myosin tail homology domain;IPR000048,IQ motif, EF-hand binding site;IPR036961,Kinesin motor domain superfamily","COG5022,Myosin heavy chain;KOG0164,Myosin class I heavy chain","GO:0030050,biological_process,vesicle transport along actin filament;GO:2000810,biological_process,regulation of bicellular tight junction assembly;GO:0031941,cellular_component,filamentous actin;GO:0030659,cellular_component,cytoplasmic vesicle membrane;GO:0017160,molecular_function,Ral GTPase binding;GO:0005102,molecular_function,signaling receptor binding;GO:0003774,molecular_function,motor activity;GO:0005886,cellular_component,plasma membrane;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0008017,molecular_function,microtubule binding;GO:0038089,biological_process,positive regulation of cell migration by vascular endothelial growth factor signaling pathway;GO:0005524,molecular_function,ATP binding;GO:0009925,cellular_component,basal plasma membrane;GO:0005737,cellular_component,cytoplasm;GO:0016604,cellular_component,nuclear body;GO:1900748,biological_process,positive regulation of vascular endothelial growth factor signaling pathway;GO:0003777,molecular_function,microtubule motor activity;GO:0030335,biological_process,positive regulation of cell migration;GO:0006605,biological_process,protein targeting;GO:0045335,cellular_component,phagocytic vesicle;GO:0016328,cellular_component,lateral plasma membrane;GO:0006612,biological_process,protein targeting to membrane;GO:0005902,cellular_component,microvillus;GO:0008022,molecular_function,protein C-terminus binding;GO:0016020,cellular_component,membrane;GO:0007018,biological_process,microtubule-based movement;GO:0016459,cellular_component,myosin complex;GO:0000166,molecular_function,nucleotide binding;GO:0032420,cellular_component,stereocilium;GO:0090314,biological_process,positive regulation of protein targeting to membrane;GO:0045121,cellular_component,membrane raft;GO:0005903,cellular_component,brush border;GO:1900078,biological_process,positive regulation of cellular response to insulin stimulus;GO:0003779,molecular_function,actin binding","-"]
["NUP62",22.24709667,7.130217825,1.640813328,6.482333909,{"v":3.66e-11,"d":"3.66E-11"},4.63E-10,"ENSG00000213024","A0A024QZF1,HCG19665, isoform CRA_a","NP_714940.1,-;NP_714941.1,-;NP_057637.2,-;NP_036478.2,nuclear pore glycoprotein p62;NP_001180286.1,-","PF05064,Nsp1-like C-terminal region","IPR026010,Nucleoporin NSP1/NUP62;IPR007758,Nucleoporin, NSP1-like, C-terminal;IPR033072,Nuclear pore glycoprotein p62, metazoa","KOG2196,Nuclear porin;ENOG410XT5X,-","GO:0007283,biological_process,spermatogenesis;GO:0051169,biological_process,nuclear transport;GO:0019894,molecular_function,kinesin binding;GO:0005642,cellular_component,annulate lamellae;GO:0046580,biological_process,negative regulation of Ras protein signal transduction;GO:0006606,biological_process,protein import into nucleus;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0030544,molecular_function,Hsp70 protein binding;GO:0051879,molecular_function,Hsp90 protein binding;GO:0051425,molecular_function,PTB domain binding;GO:0042059,biological_process,negative regulation of epidermal growth factor receptor signaling pathway;GO:0070208,biological_process,protein heterotrimerization;GO:0000278,biological_process,mitotic cell cycle;GO:0007569,biological_process,cell aging;GO:0005643,cellular_component,nuclear pore;GO:0031965,cellular_component,nuclear membrane;GO:0042306,biological_process,regulation of protein import into nucleus;GO:0043407,biological_process,negative regulation of MAP kinase activity;GO:0005634,cellular_component,nucleus;GO:0017056,molecular_function,structural constituent of nuclear pore","K14306,ko03013,RNA transport"]
["APC",5.096612443,1.633049324,1.640310981,5.419881664,{"v":6.62e-09,"d":"6.62E-09"},{"v":5.08e-08,"d":"5.08E-08"},"ENSG00000134982","Q4LE70,APC variant protein","NP_001120982.1,-;NP_000029.2,adenomatous polyposis coli protein isoform b;NP_001120983.2,adenomatous polyposis coli protein isoform a","PF16634,Unstructured region on APC between APC_crr and SAMP;PF11414,Adenomatous polyposis coli tumour suppressor protein;PF16629,Armadillo-associated region on APC;PF05937,B-1 Binding Domain;PF05956,APC basic domain;PF16633,Unstructured region on APC between 1st two creatine-rich regions;PF05924,SAMP Motif;PF05923,APC repeat;PF16635,Unstructured region on APC between SAMP and APC_crr;PF05972,APC 15 residue motif;PF16630,Unstructured region on APC between 1st and 2nd catenin-bdg motifs;PF16636,Unstructured region on APC between APC_crr regions 5 and 6;PF00514,Armadillo/beta-catenin-like repeat;PF16689,Coiled-coil N-terminus of APC, dimerisation domain","IPR009224,SAMP;IPR036149,APC, N-terminal coiled-coil domain superfamily;IPR009240,Adenomatous polyposis coli protein, 15 residue repeat;IPR000225,Armadillo;IPR032038,Adenomatous polyposis coli, N-terminal dimerisation domain;IPR016024,Armadillo-type fold;IPR026818,Adenomatous polyposis coli (APC)  family;IPR009232,EB-1 binding;IPR026836,Adenomatous polyposis coli;IPR009223,Adenomatous polyposis coli protein repeat;IPR009234,Adenomatous polyposis coli protein basic domain;IPR011989,Armadillo-like helical;IPR026831,Adenomatous polyposis coli protein","KOG2122,Beta-catenin-binding protein APC, contains ARM repeats;ENOG410XR2V,-","GO:0008013,molecular_function,beta-catenin binding;GO:0007026,biological_process,negative regulation of microtubule depolymerization;GO:0007050,biological_process,cell cycle arrest;GO:0016055,biological_process,Wnt signaling pathway;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0000281,biological_process,mitotic cytokinesis;GO:0030178,biological_process,negative regulation of Wnt signaling pathway;GO:0005737,cellular_component,cytoplasm;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0008017,molecular_function,microtubule binding;GO:0005634,cellular_component,nucleus;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0016477,biological_process,cell migration","K02085,ko05166,HTLV-I infection;K02085,ko05200,Pathways in cancer;K02085,ko05213,Endometrial cancer;K02085,ko04310,Wnt signaling pathway;K02085,ko04810,Regulation of actin cytoskeleton;K02085,ko05206,MicroRNAs in cancer;K02085,ko05217,Basal cell carcinoma;K02085,ko04550,Signaling pathways regulating pluripotency of stem cells;K02085,ko05210,Colorectal cancer;K02085,ko04390,Hippo signaling pathway"]
["FAM21A",9.711977254,3.112135842,1.639761178,5.088209635,{"v":5.1E-8,"d":"5.10E-08"},{"v":3.2e-07,"d":"3.20E-07"},"ENSG00000099290","A0A0A0MR88,WASH complex subunit 2C","-","PF15255,WASH complex subunit CAP-Z interacting, central region","IPR027308,WASH complex subunit 2;IPR029341,FAM21/CAPZIP domain","ENOG410IEJH,-;ENOG4110AMY,-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005829,cellular_component,cytosol;GO:0071203,cellular_component,WASH complex;GO:0005730,cellular_component,nucleolus","-"]
["EYA3",3.003506388,0.960297001,1.639688714,3.776943806,{"v":6.42e-05,"d":"6.42E-05"},0.000203073,"ENSG00000158161","K7D580,Eyes absent homolog","XP_016812816.1,-;XP_016812812.1,-","-","IPR028472,Eyes absent family;IPR038102,EYA domain superfamily;IPR006545,EYA domain;IPR028479,Eyes absent homologue 3","ENOG410XQHR,-;ENOG410IR14,-","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0005667,cellular_component,transcription factor complex;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0016576,biological_process,histone dephosphorylation;GO:0045739,biological_process,positive regulation of DNA repair;GO:0046872,molecular_function,metal ion binding;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006302,biological_process,double-strand break repair;GO:0010212,biological_process,response to ionizing radiation;GO:0005813,cellular_component,centrosome;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0007275,biological_process,multicellular organism development;GO:0005654,cellular_component,nucleoplasm","-"]
["FAM169A",2.838444885,0.907522661,1.639688714,3.776943806,{"v":6.42e-05,"d":"6.42E-05"},0.000203073,"ENSG00000198780","H2QR33,Uncharacterized protein","XP_009447295.1,-;XP_517703.5,-;XP_009447296.1,-","-","IPR029623,Soluble lamin-associated protein of 75kDa;IPR029625,Protein FAM169","ENOG410IK9K,-;ENOG410ZN43,-","-","-"]
["ARHGEF17",0.970850788,0.309148863,1.639558434,2.782996037,0.002421522,0.005369716,"ENSG00000110237","G3R426,Rho guanine nucleotide exchange factor 17","XP_004051828.2,rho guanine nucleotide exchange factor 17","PF00621,RhoGEF domain","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR035899,Dbl homology (DH) domain superfamily","-","GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function","-"]
["TMEM129",2.690571083,0.856760896,1.639558434,2.782996037,0.002421522,0.005369716,"ENSG00000168936","K7D040,Transmembrane protein 129","XP_016806612.1,-","PF10272,Putative transmembrane protein precursor","IPR018801,E3 ubiquitin-protein ligase TM129","ENOG410XT2B,-;KOG3899,Uncharacterized conserved protein","GO:0000209,biological_process,protein polyubiquitination;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0016567,biological_process,protein ubiquitination;GO:0005783,cellular_component,endoplasmic reticulum;GO:0030970,biological_process,retrograde protein transport, ER to cytosol;GO:0016020,cellular_component,membrane;GO:1904264,-,-;GO:0016021,cellular_component,integral component of membrane","-"]
["ZMYND19",31.43443744,10.08407736,1.63885813,5.649632213,{"v":1.98e-09,"d":"1.98E-09"},{"v":1.7E-8,"d":"1.70E-08"},"ENSG00000165724","A0A0D9RWB2,Zinc finger MYND-type containing 19","XP_008003630.1,-","PF13392,HNH endonuclease;PF01753,MYND finger","IPR003615,HNH nuclease;IPR002893,Zinc finger, MYND-type;IPR032978,Zinc finger MYND domain-containing protein 19","-","GO:0005737,cellular_component,cytoplasm;GO:0045202,cellular_component,synapse;GO:0046872,molecular_function,metal ion binding;GO:0016020,cellular_component,membrane","-"]
["PTPRK",10.21078625,3.276634451,1.638664659,5.946314343,{"v":4.28e-10,"d":"4.28E-10"},{"v":4.3e-09,"d":"4.30E-09"},"ENSG00000152894","E9PGC5,Receptor-type tyrosine-protein phosphatase kappa","-","PF00102,Protein-tyrosine phosphatase;PF00041,ibronectin type III domain;PF00629,MAM domain, meprin/A5/mu;PF07679,Immunoglobulin I-set domain","IPR003961,Fibronectin type III;IPR007110,Immunoglobulin-like domain;IPR029021,Protein-tyrosine phosphatase-like;IPR000387,Tyrosine specific protein phosphatases domain;IPR000242,PTP type protein phosphatase;IPR036116,Fibronectin type III superfamily;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR000998,MAM domain;IPR016130,Protein-tyrosine phosphatase, active site;IPR003599,Immunoglobulin subtype;IPR013098,Immunoglobulin I-set","COG5599,Protein tyrosine phosphatase;KOG4228,Protein tyrosine phosphatase","GO:0030054,cellular_component,cell junction;GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0006470,biological_process,protein dephosphorylation;GO:0016020,cellular_component,membrane;GO:0016311,biological_process,dephosphorylation;GO:0016021,cellular_component,integral component of membrane;GO:0016791,molecular_function,phosphatase activity","-"]
["NEDD4L",3.917990366,1.257717034,1.63777221,5.527512728,{"v":3.93e-09,"d":"3.93E-09"},{"v":3.16e-08,"d":"3.16E-08"},"ENSG00000049759","A0A1B0GVY1,E3 ubiquitin-protein ligase NEDD4-like","-","PF00397,WW domain;PF00632,HECT-domain (ubiquitin-transferase)","IPR000569,HECT domain;IPR001202,WW domain;IPR036020,WW domain superfamily;IPR035983,HECT, E3 ligase catalytic domain;IPR035892,C2 domain superfamily","-","GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016740,molecular_function,transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["ZNF365",3.716448874,1.191766085,1.637710409,4.534510479,{"v":1.21e-06,"d":"1.21E-06"},{"v":5.61e-06,"d":"5.61E-06"},"ENSG00000138311","H2R7P7,Zinc finger protein 365","-","-","-","ENOG410IH1N,-;ENOG4111IHT,-","-","-"]
["GPBP1",10.08985475,3.240182399,1.637152655,5.462335365,{"v":7.78e-09,"d":"7.78E-09"},{"v":5.86e-08,"d":"5.86E-08"},"ENSG00000062194","G3S8V2,GC-rich promoter binding protein 1","XP_018869014.1,-;XP_018869013.1,-;XP_018869012.1,-","PF15337,Vascular protein family Vasculin-like 1","IPR028128,Vasculin family","-","GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005886,cellular_component,plasma membrane;GO:0006351,biological_process,transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["RP11-66N24.3",7.249014611,2.32385422,1.636801906,4.035606339,{"v":1.09e-05,"d":"1.09E-05"},{"v":4.1E-5,"d":"4.10E-05"},"ENSG00000258727","F6XJX7,Adaptor related protein complex 1 gamma 2 subunit","-","PF02883,Adaptin C-terminal domain;PF01602,Adaptin N terminal region","IPR013041,Clathrin adaptor, appendage, Ig-like subdomain superfamily;IPR008152,Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain;IPR017107,Adaptor protein complex AP-1, gamma subunit;IPR002553,Clathrin/coatomer adaptor, adaptin-like, N-terminal;IPR008153,Gamma-adaptin ear (GAE) domain;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","ENOG410XPKK,-;KOG1062,Vesicle coat complex AP-1, gamma subunit","GO:0005794,cellular_component,Golgi apparatus;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0005798,cellular_component,Golgi-associated vesicle;GO:0030131,cellular_component,clathrin adaptor complex;GO:0030121,cellular_component,AP-1 adaptor complex;GO:0030133,cellular_component,transport vesicle;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0030117,cellular_component,membrane coat;GO:0006886,biological_process,intracellular protein transport","-"]
["TDP1",3.775261664,1.210255217,1.636801906,4.035606339,{"v":1.09e-05,"d":"1.09E-05"},{"v":4.1E-5,"d":"4.10E-05"},"ENSG00000042088","A0A024R6L5,Tyrosyl-DNA phosphodiesterase 1, isoform CRA_a","XP_011535245.1,-;XP_011535244.1,-;XP_006720260.1,-;XP_006720261.1,-;NP_001008744.1,-;XP_005267905.1,-;XP_016876928.1,-;XP_005267904.1,-;NP_060789.2,tyrosyl-DNA phosphodiesterase 1 isoform a","PF06087,Tyrosyl-DNA phosphodiesterase","IPR010347,Tyrosyl-DNA phosphodiesterase I;IPR027415,Tyrosyl-DNA phosphodiesterase, C-terminal","ENOG410XQPZ,-;KOG2031,Tyrosyl-DNA phosphodiesterase","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0006281,biological_process,DNA repair;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0005886,cellular_component,plasma membrane;GO:0005634,cellular_component,nucleus","-"]
["DIDO1",7.437950488,2.393144656,1.634938602,6.049941909,3.29E-10,{"v":3.38e-09,"d":"3.38E-09"},"ENSG00000101191","K7DQ90,Death inducer-obliterator 1","XP_016793764.1,-;XP_016793768.1,-;XP_016793767.1,-;XP_016793766.1,-;XP_016793762.1,death-inducer obliterator 1 isoform X1;XP_016793763.1,-","PF07500,Transcription factor S-II (TFIIS), central domain;PF00628,PHD-finger;PF07744,SPOC domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR036575,Transcription elongation factor S-II, central domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR012921,Spen paralogue and orthologue SPOC, C-terminal;IPR003618,Transcription elongation factor S-II, central domain;IPR019787,Zinc finger, PHD-finger;IPR019786,Zinc finger, PHD-type, conserved site;IPR033082,Death-inducer obliterator 1","ENOG411031H,-;KOG1632,Uncharacterized PHD Zn-finger protein;KOG1634,Predicted transcription factor DATF1, contains PHD and TFS2M domains","GO:0097190,biological_process,apoptotic signaling pathway;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0006351,biological_process,transcription, DNA-templated","-"]
["TBRG1",4.156537929,1.334980084,1.634763657,4.254574474,{"v":4.57e-06,"d":"4.57E-06"},{"v":1.87e-05,"d":"1.87E-05"},"ENSG00000154144","H2NFQ5,Transforming growth factor beta regulator 1","XP_002822686.1,transforming growth factor beta regulator 1 isoform X1","PF05965,/Y rich C-terminus;PF05964,/Y-rich N-terminus","IPR003889,FY-rich, C-terminal;IPR003888,FY-rich, N-terminal","ENOG410ITPM,-;ENOG410XTBM,-","GO:0050821,biological_process,protein stabilization;GO:0007050,biological_process,cell cycle arrest;GO:0006260,biological_process,DNA replication;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0005634,cellular_component,nucleus;GO:1990173,biological_process,protein localization to nucleoplasm","-"]
["CREG1",22.35022945,7.192017582,1.634081126,5.345266378,{"v":1.37E-8,"d":"1.37E-08"},{"v":9.81e-08,"d":"9.81E-08"},"ENSG00000143162","K7ADC2,Cellular repressor of E1A-stimulated genes 1","-","PF13883,Pyridoxamine 5'-phosphate oxidase","IPR014631,Cellular repressor of E1A-stimulated genes (CREG);IPR012349,FMN-binding split barrel","KOG3374,Cellular repressor of transcription;ENOG4111WS9,-","GO:0048037,molecular_function,cofactor binding","-"]
["TPP1",1.259735519,0.40113868,1.633928577,2.263709398,0.017311675,0.030736627,"ENSG00000166340","D3DQU2,Tripeptidyl peptidase I, isoform CRA_a","-","PF09286,Pro-kumamolisin, activation domain","IPR015366,Peptidase S53, activation domain;IPR036852,Peptidase S8/S53 domain superfamily;IPR030400,Sedolisin domain","ENOG410IICY,-;COG4934,Predicted protease","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0046872,molecular_function,metal ion binding;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0008236,molecular_function,serine-type peptidase activity;GO:0008233,molecular_function,peptidase activity","-"]
["ZNF432",1.031572895,0.328484657,1.633928577,2.263709398,0.017311675,0.030736627,"ENSG00000256087","A0A024R4I3,HCG2008146, isoform CRA_c","NP_001309214.1,-;NP_001309213.1,-;NP_055465.1,zinc finger protein 432","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0005654,cellular_component,nucleoplasm;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["VIL1",0.892191297,0.284101253,1.633928577,2.263709398,0.017311675,0.030736627,"ENSG00000127831","Q53F91,Villin 1 variant","NP_009058.2,villin-1","PF02209,Villin headpiece domain;PF00626,elsolin repeat","IPR007123,Gelsolin-like domain;IPR036180,Gelsolin-like domain superfamily;IPR003128,Villin headpiece;IPR036886,Villin headpiece domain superfamily;IPR029006,ADF-H/Gelsolin-like domain superfamily;IPR007122,Villin/Gelsolin;IPR030007,Villin","KOG0443,Actin regulatory proteins (gelsolin/villin family);ENOG410XR0A,-","GO:0045010,biological_process,actin nucleation;GO:0051014,biological_process,actin filament severing;GO:0051693,biological_process,actin filament capping;GO:0005546,molecular_function,phosphatidylinositol-4,5-bisphosphate binding;GO:0007010,biological_process,cytoskeleton organization;GO:0005509,molecular_function,calcium ion binding;GO:0003779,molecular_function,actin binding;GO:0051015,molecular_function,actin filament binding","-"]
["AAED1",2.00193378,0.63747752,1.633928577,2.263709398,0.017311675,0.030736627,"ENSG00000158122","H2R6K6,Chromosome 9 open reading frame 21","XP_520707.2,thioredoxin-like protein AAED1 isoform X1","PF13911,AhpC/TSA antioxidant enzyme","IPR032801,Peroxiredoxin-like FAM213/AAED1;IPR036249,Thioredoxin-like superfamily","ENOG410IT73,-;ENOG4111SUS,-","GO:0098869,biological_process,cellular oxidant detoxification;GO:0055114,biological_process,oxidation-reduction process;GO:0016209,molecular_function,antioxidant activity","-"]
["SPAST",8.791446008,2.828477849,1.633793832,4.96431904,{"v":1.14E-7,"d":"1.14E-07"},{"v":6.62e-07,"d":"6.62E-07"},"ENSG00000021574","H2QHQ4,Spastin","XP_001164367.1,-","PF09336,Vps4 C terminal oligomerisation domain;PF00004,ATPase family associated with various cellular activities (AAA)","IPR007330,MIT;IPR003960,ATPase, AAA-type, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR015415,Vps4 oligomerisation, C-terminal;IPR017179,Spastin;IPR035106,Spastin, chordate;IPR003593,AAA+ ATPase domain;IPR003959,ATPase, AAA-type, core","COG0464,ATPases of the AAA+ class;KOG0740,AAA+-type ATPase","GO:0007409,biological_process,axonogenesis;GO:0019896,biological_process,axonal transport of mitochondrion;GO:0090148,biological_process,membrane fission;GO:0008089,biological_process,anterograde axonal transport;GO:0005783,cellular_component,endoplasmic reticulum;GO:0010458,biological_process,exit from mitosis;GO:0030154,biological_process,cell differentiation;GO:0051260,biological_process,protein homooligomerization;GO:0043014,molecular_function,alpha-tubulin binding;GO:0005815,cellular_component,microtubule organizing center;GO:1904115,cellular_component,axon cytoplasm;GO:0051301,biological_process,cell division;GO:0008017,molecular_function,microtubule binding;GO:0031117,biological_process,positive regulation of microtubule depolymerization;GO:0005524,molecular_function,ATP binding;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0007049,biological_process,cell cycle;GO:0016787,molecular_function,hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0000166,molecular_function,nucleotide binding;GO:0003824,molecular_function,catalytic activity;GO:0031468,biological_process,nuclear envelope reassembly;GO:0034214,biological_process,protein hexamerization;GO:0048487,molecular_function,beta-tubulin binding;GO:0005813,cellular_component,centrosome;GO:0005829,cellular_component,cytosol;GO:0032467,biological_process,positive regulation of cytokinesis;GO:0016021,cellular_component,integral component of membrane;GO:0030496,cellular_component,midbody;GO:0051228,biological_process,mitotic spindle disassembly;GO:0005634,cellular_component,nucleus;GO:0005768,cellular_component,endosome;GO:0007399,biological_process,nervous system development;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0031965,cellular_component,nuclear membrane;GO:0001578,biological_process,microtubule bundle formation;GO:0032506,biological_process,cytokinetic process;GO:0005654,cellular_component,nucleoplasm;GO:0005874,cellular_component,microtubule;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0005856,cellular_component,cytoskeleton;GO:0005819,cellular_component,spindle;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0000281,biological_process,mitotic cytokinesis;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0051013,biological_process,microtubule severing;GO:0008568,molecular_function,microtubule-severing ATPase activity;GO:0016887,molecular_function,ATPase activity;GO:0007275,biological_process,multicellular organism development","-"]
["KCNJ2",8.941479381,2.878879112,1.632912223,5.083100308,{"v":6.03e-08,"d":"6.03E-08"},{"v":3.72E-7,"d":"3.72E-07"},"ENSG00000123700","G3QRH4,Potassium voltage-gated channel subfamily J member 2","-","PF01007,Inward rectifier potassium channel;PF08466,Inward rectifier potassium channel N-terminal","-","-","-","-"]
["HADHA",51.4673524,16.59381918,1.63247972,7.029903561,{"v":5.03e-12,"d":"5.03E-12"},{"v":7.69e-11,"d":"7.69E-11"},"ENSG00000084754","E9KL44,Epididymis tissue sperm binding protein Li 14m","NP_000173.2,trifunctional enzyme subunit alpha, mitochondrial precursor","PF02737,3-hydroxyacyl-CoA dehydrogenase, NAD binding domain;PF00725,3-hydroxyacyl-CoA dehydrogenase, C-terminal domain;PF00378,noyl-CoA hydratase/isomerase","IPR036291,NAD(P)-binding domain superfamily;IPR006108,3-hydroxyacyl-CoA dehydrogenase, C-terminal;IPR006180,3-hydroxyacyl-CoA dehydrogenase, conserved site;IPR018376,Enoyl-CoA hydratase/isomerase, conserved site;IPR012803,Fatty acid oxidation complex, alpha subunit, mitochondrial;IPR029045,ClpP/crotonase-like domain superfamily;IPR006176,3-hydroxyacyl-CoA dehydrogenase, NAD binding;IPR008927,6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily;IPR001753,Enoyl-CoA hydratase/isomerase","COG1024,Enoyl-CoA hydratase/carnithine racemase;COG1250,3-hydroxyacyl-CoA dehydrogenase;KOG1683,Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase","GO:0016509,molecular_function,long-chain-3-hydroxyacyl-CoA dehydrogenase activity;GO:0006631,biological_process,fatty acid metabolic process;GO:0032868,biological_process,response to insulin;GO:0003857,molecular_function,3-hydroxyacyl-CoA dehydrogenase activity;GO:0016507,cellular_component,mitochondrial fatty acid beta-oxidation multienzyme complex;GO:0000062,molecular_function,fatty-acyl-CoA binding;GO:0003824,molecular_function,catalytic activity;GO:0016508,molecular_function,long-chain-enoyl-CoA hydratase activity;GO:0004300,molecular_function,enoyl-CoA hydratase activity;GO:0006635,biological_process,fatty acid beta-oxidation;GO:0016491,molecular_function,oxidoreductase activity;GO:0051287,molecular_function,NAD binding;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0003988,molecular_function,acetyl-CoA C-acyltransferase activity;GO:0042493,biological_process,response to drug","K07515,ko00640,Propanoate metabolism;K07515,ko00930,Caprolactam degradation;K07515,ko00410,beta-Alanine metabolism;K07515,ko01212,Fatty acid metabolism;K07515,ko00627,Aminobenzoate degradation;K07515,ko01040,Biosynthesis of unsaturated fatty acids;K07515,ko00310,Lysine degradation;K07515,ko00650,Butanoate metabolism;K07515,ko00062,Fatty acid elongation;K07515,ko00280,Valine, leucine and isoleucine degradation;K07515,ko01200,Carbon metabolism;K07515,ko00071,Fatty acid degradation;K07515,ko00380,Tryptophan metabolism"]
["OLFML2A",6.934427605,2.234289723,1.631730815,4.993584908,{"v":8.41e-08,"d":"8.41E-08"},{"v":5.03e-07,"d":"5.03E-07"},"ENSG00000185585","K7C5H9,Olfactomedin-like 2A","XP_520250.3,olfactomedin-like protein 2A isoform X2","PF02191,Olfactomedin-like domain","IPR031231,Olfactomedin-like protein 2A;IPR003112,Olfactomedin-like domain","KOG3545,Olfactomedin and related extracellular matrix glycoproteins;ENOG410ZJ72,-","GO:0042803,molecular_function,protein homodimerization activity;GO:0005578,,;GO:0030198,biological_process,extracellular matrix organization;GO:0050840,molecular_function,extracellular matrix binding","-"]
["ACTN1",26.0790504,8.418230802,1.630926525,7.525757329,{"v":9.99e-13,"d":"9.99E-13"},{"v":1.82e-11,"d":"1.82E-11"},"ENSG00000072110","G3RK88,Actinin alpha 1","XP_004055392.1,alpha-actinin-1 isoform X3","PF00435,Spectrin repeat;PF08726,Ca2+ insensitive EF hand;PF00307,Calponin homology (CH) domain","IPR026921,Alpha-actinin 1;IPR001715,Calponin homology domain;IPR002017,Spectrin repeat;IPR018159,Spectrin/alpha-actinin;IPR036872,CH domain superfamily;IPR002048,EF-hand domain;IPR014837,EF-hand, Ca insensitive;IPR011992,EF-hand domain pair;IPR001589,Actinin-type actin-binding domain, conserved site","-","GO:0001725,cellular_component,stress fiber;GO:0005509,molecular_function,calcium ion binding;GO:0051017,biological_process,actin filament bundle assembly;GO:0048741,biological_process,skeletal muscle fiber development;GO:0005925,cellular_component,focal adhesion;GO:0051764,biological_process,actin crosslink formation;GO:0005923,cellular_component,bicellular tight junction;GO:0042383,cellular_component,sarcolemma;GO:0042803,molecular_function,protein homodimerization activity;GO:0030027,cellular_component,lamellipodium;GO:0051015,molecular_function,actin filament binding;GO:0097433,cellular_component,dense body;GO:0030486,cellular_component,smooth muscle dense body;GO:0005915,cellular_component,zonula adherens;GO:0016328,cellular_component,lateral plasma membrane;GO:1990357,cellular_component,terminal web;GO:0017166,molecular_function,vinculin binding;GO:0003779,molecular_function,actin binding;GO:0090637,cellular_component,inner dense plaque of desmosome;GO:0045214,biological_process,sarcomere organization;GO:0031252,cellular_component,cell leading edge;GO:0051393,molecular_function,alpha-actinin binding;GO:0090636,cellular_component,outer dense plaque of desmosome","-"]
["CAPZA1",40.53496427,13.09067032,1.630006288,6.803783325,1.25E-11,{"v":1.76e-10,"d":"1.76E-10"},"ENSG00000116489","G2HHJ5,F-actin capping protein alpha-1 subunit","NP_001267211.1,-","PF01267,-actin capping protein alpha subunit","IPR037282,F-actin-capping protein subunit alpha/beta;IPR002189,F-actin-capping protein subunit alpha;IPR017865,F-actin capping protein, alpha subunit, conserved site","KOG0836,F-actin capping protein, alpha subunit;ENOG410ZAWX,-","GO:0051016,biological_process,barbed-end actin filament capping;GO:0008290,cellular_component,F-actin capping protein complex;GO:0003779,molecular_function,actin binding;GO:0051693,biological_process,actin filament capping","K10364,ko04144,Endocytosis"]
["RAB4A",14.41978526,4.652622936,1.629752621,5.022267419,{"v":7.4e-08,"d":"7.40E-08"},{"v":4.47e-07,"d":"4.47E-07"},"ENSG00000168118","F7HBG0,Ras-related protein Rab-4A isoform 1","XP_002760619.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0086,GTPase Rab4, small G protein superfamily;ENOG410XQ9X,-","GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity","K07879,ko04144,Endocytosis"]
["RP11-732A19.8",25.59094298,8.212116418,1.629586283,2.912967957,0.002976471,0.006425265,"ENSG00000254400","Q59FP4,Integrin-linked kinase variant","-","-","IPR036770,Ankyrin repeat-containing domain superfamily","KOG0195,Integrin-linked kinase;COG0666,FOG: Ankyrin repeat","GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation","-"]
["LTBP2",1.123175255,0.360426185,1.629586283,2.912967957,0.002976471,0.006425265,"ENSG00000119681","Q6AZ94,Latent transforming growth factor beta binding protein 2","-","PF00008,-like domain;PF07645,Calcium-binding EGF domain;PF00683,TB domain","IPR018097,EGF-like calcium-binding, conserved site;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR001881,EGF-like calcium-binding domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR017878,TB domain;IPR036773,TGF-beta binding (TB) domain superfamily","ENOG410XSTY,-;ENOG410IR7H,-","GO:0005509,molecular_function,calcium ion binding","-"]
["ATOH8",1.680511232,0.539274926,1.629586283,2.912967957,0.002976471,0.006425265,"ENSG00000168874","D6W5L8,Atonal homolog 8","-","PF00010,Helix-loop-helix DNA-binding domain","IPR032660,Protein atonal homologue 8;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","ENOG410IQ4E,-;ENOG4111WSZ,-","GO:0030154,biological_process,cell differentiation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0046983,molecular_function,protein dimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity","-"]
["TTC4",11.51281113,3.716058351,1.628833665,4.795861355,{"v":3.23e-07,"d":"3.23E-07"},{"v":1.68E-6,"d":"1.68E-06"},"ENSG00000243725","K7A195,Tetratricopeptide repeat domain 4","XP_009456603.2,tetratricopeptide repeat protein 4 isoform X1","-","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","COG0457,FOG: TPR repeat;KOG0551,Hsp90 co-chaperone CNS1 (contains TPR repeats)","-","-"]
["PLEKHA8",2.785192775,0.898811947,1.628154969,4.348375009,{"v":3.87e-06,"d":"3.87E-06"},{"v":1.61e-05,"d":"1.61E-05"},"ENSG00000106086","J3KQS5,Pleckstrin homology domain-containing family A member 8","-","PF08718,lycolipid transfer protein (GLTP);PF00169,PH domain","IPR011993,PH-like domain superfamily;IPR036497,Glycolipid transfer protein superfamily;IPR001849,Pleckstrin homology domain;IPR014830,Glycolipid transfer protein domain","KOG3221,Glycolipid transfer protein;ENOG410YFEA,-","GO:0005737,cellular_component,cytoplasm;GO:0005794,cellular_component,Golgi apparatus;GO:0120009,biological_process,intermembrane lipid transfer;GO:0120013,molecular_function,intermembrane lipid transfer activity;GO:0005654,cellular_component,nucleoplasm","-"]
["SUFU",2.075398211,0.668213872,1.62770276,3.356467394,0.000289093,0.000790412,"ENSG00000107882","G7N110,Suppressor of fused homolog","-","PF05076,Suppressor of fused protein (SUFU);PF12470,Suppressor of Fused Gli/Ci N terminal binding domain","IPR037181,Suppressor of fused, N-terminal;IPR024314,Suppressor of fused C-terminal;IPR020941,Suppressor of fused-like domain;IPR007768,Suppressor of fused;IPR016591,Suppressor of fused, eukaryotic;IPR038489,Suppressor of fused, C-terminal domain superfamily","ENOG410XRUC,-;ENOG410IFRJ,-","GO:0005737,cellular_component,cytoplasm;GO:0008134,molecular_function,transcription factor binding;GO:0005634,cellular_component,nucleus;GO:0007275,biological_process,multicellular organism development","-"]
["NRP2",2.40946175,0.778129943,1.627525075,4.526961377,{"v":1.49e-06,"d":"1.49E-06"},{"v":6.8e-06,"d":"6.80E-06"},"ENSG00000118257","X5D2Q8,Neuropilin 2 isoform A","-","PF00754,5/8 type C domain;PF00431,CUB domain;PF11980,C-terminal domain of neuropilin glycoprotein;PF00629,MAM domain, meprin/A5/mu","IPR000421,Coagulation factor 5/8 C-terminal domain;IPR035914,Spermadhesin, CUB domain superfamily;IPR022579,Neuropilin, C-terminal;IPR027143,Neuropilin-2;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000859,CUB domain;IPR000998,MAM domain;IPR008979,Galactose-binding-like domain superfamily;IPR014648,Neuropilin","-","GO:0001755,biological_process,neural crest cell migration;GO:0097490,biological_process,sympathetic neuron projection extension;GO:0061551,biological_process,trigeminal ganglion development;GO:0005021,molecular_function,vascular endothelial growth factor-activated receptor activity;GO:0021828,biological_process,gonadotrophin-releasing hormone neuronal migration to the hypothalamus;GO:0007507,biological_process,heart development;GO:0007411,biological_process,axon guidance;GO:1904835,biological_process,dorsal root ganglion morphogenesis;GO:0021612,biological_process,facial nerve structural organization;GO:0021649,biological_process,vestibulocochlear nerve structural organization;GO:0097374,biological_process,sensory neuron axon guidance;GO:0048846,biological_process,axon extension involved in axon guidance;GO:0003148,biological_process,outflow tract septum morphogenesis;GO:0021675,biological_process,nerve development;GO:0016021,cellular_component,integral component of membrane;GO:0030424,cellular_component,axon;GO:0050919,biological_process,negative chemotaxis;GO:0017154,molecular_function,semaphorin receptor activity;GO:0038084,biological_process,vascular endothelial growth factor signaling pathway;GO:0001525,biological_process,angiogenesis;GO:0016020,cellular_component,membrane;GO:0001764,biological_process,neuron migration;GO:1903375,biological_process,facioacoustic ganglion development;GO:1902285,biological_process,semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:1901166,biological_process,neural crest cell migration involved in autonomic nervous system development;GO:0036486,biological_process,ventral trunk neural crest cell migration;GO:0046872,molecular_function,metal ion binding;GO:0061549,biological_process,sympathetic ganglion development;GO:0097491,biological_process,sympathetic neuron projection guidance;GO:1990830,biological_process,cellular response to leukemia inhibitory factor","-"]
["SMG9",4.733026738,1.529399201,1.627030797,4.685756714,{"v":4.99e-07,"d":"4.99E-07"},{"v":2.51e-06,"d":"2.51E-06"},"ENSG00000105771","G2HFB3,Chromosome 19 open reading frame 61","XP_016789560.1,-;XP_016789561.1,-;XP_009434027.1,-;NP_001233489.1,-","PF10220,Smg8_Smg9","IPR019354,Smg8/Smg9","KOG4181,Uncharacterized conserved protein;ENOG410XSTF,-","GO:0007507,biological_process,heart development;GO:0001654,biological_process,eye development;GO:0000184,biological_process,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0005622,cellular_component,intracellular;GO:0007420,biological_process,brain development;GO:0042802,molecular_function,identical protein binding","-"]
["CDYL",29.92490465,9.690333622,1.625964058,6.503475742,{"v":4.29e-11,"d":"4.29E-11"},{"v":5.3e-10,"d":"5.30E-10"},"ENSG00000153046","H2QS88,Chromodomain Y like","XP_016810341.1,chromodomain Y-like protein isoform X1","PF00385,Chromo (CHRromatin Organisation MOdifier) domain;PF00378,noyl-CoA hydratase/isomerase","IPR023780,Chromo domain;IPR016197,Chromo-like domain superfamily;IPR023779,Chromo domain, conserved site;IPR014748,Enoyl-CoA hydratase, C-terminal;IPR001753,Enoyl-CoA hydratase/isomerase;IPR029045,ClpP/crotonase-like domain superfamily;IPR000953,Chromo/chromo shadow domain","COG1024,Enoyl-CoA hydratase/carnithine racemase;KOG0016,Enoyl-CoA hydratase/isomerase;KOG1911,Heterochromatin-associated protein HP1 and related CHROMO domain proteins","GO:0120094,biological_process,negative regulation of peptidyl-lysine crotonylation;GO:0016607,cellular_component,nuclear speck;GO:0003824,molecular_function,catalytic activity;GO:0005634,cellular_component,nucleus;GO:0003714,molecular_function,transcription corepressor activity;GO:0008152,biological_process,metabolic process;GO:0120092,molecular_function,crotonyl-CoA hydratase activity;GO:1903507,biological_process,negative regulation of nucleic acid-templated transcription;GO:0035064,molecular_function,methylated histone binding;GO:0030674,molecular_function,protein binding, bridging","-"]
["ZNF598",24.75121702,8.015591615,1.625728026,6.285277166,{"v":1.25e-10,"d":"1.25E-10"},{"v":1.39E-9,"d":"1.39E-09"},"ENSG00000167962","H3BQQ2,E3 ubiquitin-protein ligase ZNF598","-","-","IPR013087,Zinc finger C2H2-type","COG5236,Uncharacterized conserved protein, contains RING Zn-finger;KOG2231,Predicted E3 ubiquitin ligase","GO:0003676,molecular_function,nucleic acid binding","-"]
["KCTD9",10.61879728,3.438858881,1.624394251,4.988123748,{"v":1e-07,"d":"1.00E-07"},{"v":5.87e-07,"d":"5.87E-07"},"ENSG00000104756","F6QPZ2,BTB/POZ domain-containing protein KCTD9","NP_001247831.1,-","PF02214,BTB/POZ domain;PF11834,KHA, dimerisation domain of potassium ion channel;PF00805,Pentapeptide repeats (8 copies)","IPR021789,KHA domain;IPR003131,Potassium channel tetramerisation-type BTB domain;IPR011333,SKP1/BTB/POZ domain superfamily;IPR036572,Doublecortin domain superfamily;IPR001646,Pentapeptide repeat;IPR000210,BTB/POZ domain","KOG1665,AFH1-interacting protein FIP2, contains BTB/POZ domain and pentapeptide repeats;COG1357,Uncharacterized low-complexity proteins","GO:0097602,molecular_function,cullin family protein binding;GO:0043621,molecular_function,protein self-association;GO:0035556,biological_process,intracellular signal transduction;GO:0051260,biological_process,protein homooligomerization;GO:0005622,cellular_component,intracellular;GO:0042802,molecular_function,identical protein binding","-"]
["NDE1",27.31308638,8.85737542,1.623954211,6.653460584,{"v":2.51e-11,"d":"2.51E-11"},{"v":3.32e-10,"d":"3.32E-10"},"ENSG00000072864","H2NQ82,NudE neurodevelopment protein 1","-","PF04880,NUDE protein, C-terminal conserved region","IPR033494,NUDE family;IPR006964,NUDE domain","ENOG410XPMP,-;KOG1853,LIS1-interacting protein NUDE","GO:0051303,biological_process,establishment of chromosome localization;GO:0007020,biological_process,microtubule nucleation;GO:0021987,biological_process,cerebral cortex development;GO:0005819,cellular_component,spindle;GO:0008017,molecular_function,microtubule binding;GO:0000132,biological_process,establishment of mitotic spindle orientation;GO:0000776,cellular_component,kinetochore;GO:2000574,biological_process,regulation of microtubule motor activity;GO:0007405,biological_process,neuroblast proliferation;GO:0045202,cellular_component,synapse;GO:0005815,cellular_component,microtubule organizing center;GO:0005813,cellular_component,centrosome;GO:0030900,biological_process,forebrain development;GO:0051298,biological_process,centrosome duplication;GO:0031023,biological_process,microtubule organizing center organization;GO:0047496,biological_process,vesicle transport along microtubule;GO:0042802,molecular_function,identical protein binding;GO:0031616,cellular_component,spindle pole centrosome;GO:0001764,biological_process,neuron migration","-"]
["MED29",20.55717555,6.664341256,1.623795956,5.73217529,{"v":1.88e-09,"d":"1.88E-09"},{"v":1.62e-08,"d":"1.62E-08"},"ENSG00000063322","G3QHI8,Mediator complex subunit 29","XP_004060760.1,-","PF11568,Mediator complex subunit 29","IPR021018,Mediator complex, subunit Med29, metazoa","-","GO:0016592,cellular_component,mediator complex;GO:0005654,cellular_component,nucleoplasm","-"]
["IMPAD1",14.22759627,4.616801241,1.622770268,6.180384447,{"v":2.48e-10,"d":"2.48E-10"},{"v":2.6e-09,"d":"2.60E-09"},"ENSG00000104331","K7CJG0,Inositol monophosphatase domain containing 1","-","PF00459,Inositol monophosphatase family","IPR020550,Inositol monophosphatase, conserved site;IPR000760,Inositol monophosphatase-like","KOG3853,Inositol monophosphatase;COG1218,3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase","GO:0046854,biological_process,phosphatidylinositol phosphorylation;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CEP97",2.436763795,0.789137093,1.622176652,4.024851636,{"v":1.39e-05,"d":"1.39E-05"},{"v":5.14e-05,"d":"5.14E-05"},"ENSG00000182504","K7B4R7,Centrosomal protein 97kDa","-","PF14580,Leucine-rich repeat","IPR001611,Leucine-rich repeat;IPR032675,Leucine-rich repeat domain superfamily;IPR000048,IQ motif, EF-hand binding site","KOG0531,Protein phosphatase 1, regulatory subunit, and related proteins;COG4886,Leucine-rich repeat (LRR) protein","-","-"]
["G2E3",2.082307217,0.673985651,1.622018141,3.764010895,{"v":8.35e-05,"d":"8.35E-05"},0.00025684,"ENSG00000092140","G3V483,G2/M phase-specific E3 ubiquitin-protein ligase","-","PF00632,HECT-domain (ubiquitin-transferase);PF13771,PHD-like zinc-binding domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR000569,HECT domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR034732,Extended PHD (ePHD) domain;IPR019786,Zinc finger, PHD-type, conserved site;IPR035983,HECT, E3 ligase catalytic domain","ENOG410IPTH,-;ENOG410ZNVY,-","GO:0016567,biological_process,protein ubiquitination;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0005829,cellular_component,cytosol","-"]
["ZMYM5",3.005824624,0.970723915,1.621358358,3.032028013,0.00149235,0.003463569,"ENSG00000132950","H2Q791,Zinc finger, MYM-type 5","-","PF06467,MYM-type Zinc finger with FCS sequence motif","IPR011017,TRASH domain;IPR010507,Zinc finger, MYM-type","ENOG410JNGQ,-;ENOG41113IZ,-","GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0007010,biological_process,cytoskeleton organization;GO:0022604,biological_process,regulation of cell morphogenesis;GO:0007275,biological_process,multicellular organism development;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["UBXN8",3.469265411,1.120391015,1.621358358,3.032028013,0.00149235,0.003463569,"ENSG00000104691","A0A087WT23,UBX domain-containing protein 8","-","PF00789,UBX domain","IPR017247,UBX domain-containing protein 8;IPR029071,Ubiquitin-like domain superfamily;IPR001012,UBX domain","-","GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0005730,cellular_component,nucleolus;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["FAM216A",2.58765142,0.833143522,1.620470825,2.447733345,0.011048418,0.020793146,"ENSG00000204856","H2R750,Uncharacterized protein","-","PF15107,AM216B protein family","IPR029373,FAM216","ENOG4111DX3,-;ENOG410IG55,-","-","-"]
["CTPS2",1.292886453,0.416269349,1.620470825,2.447733345,0.011048418,0.020793146,"ENSG00000047230","A0A024RC00,CTP synthase","XP_006724566.1,-;NP_062831.3,CTP synthase 2;NP_787055.1,-;XP_005274619.1,-;NP_001137474.1,-","PF00117,lutamine amidotransferase class-I;PF06418,CTP synthase N-terminus","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR017926,Glutamine amidotransferase;IPR017456,CTP synthase, N-terminal;IPR004468,CTP synthase;IPR029062,Class I glutamine amidotransferase-like;IPR033828,CTP synthase GATase domain","COG0504,CTP synthase (UTP-ammonia lyase);KOG2387,CTP synthase (UTP-ammonia lyase)","GO:0044210,biological_process,'de novo' CTP biosynthetic process;GO:0003883,molecular_function,CTP synthase activity;GO:0006221,biological_process,pyrimidine nucleotide biosynthetic process;GO:0006241,biological_process,CTP biosynthetic process;GO:0006541,biological_process,glutamine metabolic process;GO:0016874,molecular_function,ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0005739,cellular_component,mitochondrion","K01937,ko00240,Pyrimidine metabolism"]
["PLS1",7.62527856,2.475734379,1.620379274,4.789584021,{"v":3.23e-07,"d":"3.23E-07"},{"v":1.68E-6,"d":"1.68E-06"},"ENSG00000120756","H2QNI7,Plastin 1","XP_009444870.1,-;XP_001162294.1,-;XP_016797593.1,-","PF13499,-hand domain pair;PF00307,Calponin homology (CH) domain","IPR018247,EF-Hand 1, calcium-binding site;IPR036872,CH domain superfamily;IPR001715,Calponin homology domain;IPR002048,EF-hand domain;IPR030235,Plastin-1;IPR001589,Actinin-type actin-binding domain, conserved site;IPR011992,EF-hand domain pair","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);KOG0046,Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily","GO:0051639,biological_process,actin filament network formation;GO:0051764,biological_process,actin crosslink formation;GO:1903078,biological_process,positive regulation of protein localization to plasma membrane;GO:0005884,cellular_component,actin filament;GO:0005737,cellular_component,cytoplasm;GO:0040018,biological_process,positive regulation of multicellular organism growth;GO:1990357,cellular_component,terminal web;GO:1902896,biological_process,terminal web assembly;GO:0001951,biological_process,intestinal D-glucose absorption;GO:0005509,molecular_function,calcium ion binding;GO:0005903,cellular_component,brush border;GO:0032532,biological_process,regulation of microvillus length;GO:0051017,biological_process,actin filament bundle assembly;GO:0032432,cellular_component,actin filament bundle;GO:0051015,molecular_function,actin filament binding;GO:0003779,molecular_function,actin binding","-"]
["SH2D4A",37.89744845,12.32292609,1.620100551,6.716161222,2.03E-11,{"v":2.74e-10,"d":"2.74E-10"},"ENSG00000104611","K7BDW8,SH2 domain containing 4A","-","PF00017,SH2 domain","-","-","-","-"]
["KLF6",5.260560313,1.707970393,1.619742101,4.478493686,{"v":1.74e-06,"d":"1.74E-06"},{"v":7.83e-06,"d":"7.83E-06"},"ENSG00000067082","G3QI26,Kruppel like factor 6","XP_004049038.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["AL109923.1",81.15061185,26.39873705,1.619571455,6.936202141,{"v":1e-11,"d":"1.00E-11"},{"v":1.44e-10,"d":"1.44E-10"},"ENSG00000283472","K7BGN1,E3 ubiquitin-protein ligase","XP_003954476.3,-;XP_016793219.1,-","PF00397,WW domain;PF00632,HECT-domain (ubiquitin-transferase);PF00168,C2 domain","IPR001202,WW domain;IPR000569,HECT domain;IPR024928,E3 ubiquitin-protein ligase, SMURF1 type;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR036020,WW domain superfamily;IPR035983,HECT, E3 ligase catalytic domain","KOG0940,Ubiquitin protein ligase RSP5/NEDD4;COG5021,Ubiquitin-protein ligase","GO:0000209,biological_process,protein polyubiquitination;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0032991,cellular_component,protein-containing complex;GO:0005938,cellular_component,cell cortex;GO:0005886,cellular_component,plasma membrane;GO:0005769,cellular_component,early endosome;GO:0090085,biological_process,regulation of protein deubiquitination;GO:0046329,biological_process,negative regulation of JNK cascade;GO:0005634,cellular_component,nucleus;GO:0045732,biological_process,positive regulation of protein catabolic process;GO:0046642,biological_process,negative regulation of alpha-beta T cell proliferation;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0045236,molecular_function,CXCR chemokine receptor binding;GO:1990763,molecular_function,arrestin family protein binding;GO:2000646,biological_process,positive regulation of receptor catabolic process;GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0005654,cellular_component,nucleoplasm;GO:0016740,molecular_function,transferase activity;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0070936,biological_process,protein K48-linked ubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0051865,biological_process,protein autoubiquitination;GO:0016020,cellular_component,membrane;GO:0035519,biological_process,protein K29-linked ubiquitination;GO:0043021,molecular_function,ribonucleoprotein complex binding;GO:0002669,biological_process,positive regulation of T cell anergy;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0050687,biological_process,negative regulation of defense response to virus;GO:0016567,biological_process,protein ubiquitination;GO:0070534,biological_process,protein K63-linked ubiquitination;GO:0044389,molecular_function,ubiquitin-like protein ligase binding;GO:0016874,molecular_function,ligase activity","K05632,ko04668,TNF signaling pathway;K05632,ko04120,Ubiquitin mediated proteolysis;K05632,ko04144,Endocytosis;K05632,ko04932,Non-alcoholic fatty liver disease (NAFLD)"]
["RELA",31.33396134,10.19450689,1.619333985,6.838449732,1.45E-11,2.02E-10,"ENSG00000173039","G3SHV6,RELA proto-oncogene, NF-kB subunit","XP_018892402.1,-","PF00554,Rel homology DNA-binding domain;PF16179,Rel homology dimerisation domain","IPR011539,Rel homology domain (RHD), DNA-binding domain;IPR008967,p53-like transcription factor, DNA-binding;IPR032397,Rel homology dimerisation domain;IPR030492,Rel homology domain, conserved site;IPR037059,Rel homology domain (RHD), DNA-binding domain superfamily;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set;IPR002909,IPT domain;IPR030495,Transcription factor RelA (p65);IPR033926,NFkappaB IPT domain;IPR000451,NF-kappa-B/Dorsal","-","GO:0010033,biological_process,response to organic substance;GO:0003705,molecular_function,transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0071316,biological_process,cellular response to nicotine;GO:0019901,molecular_function,protein kinase binding;GO:0051059,molecular_function,NF-kappaB binding;GO:0071223,biological_process,cellular response to lipoteichoic acid;GO:0009617,biological_process,response to bacterium;GO:0035994,biological_process,response to muscle stretch;GO:0043620,biological_process,regulation of DNA-templated transcription in response to stress;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001205,molecular_function,transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0050862,biological_process,positive regulation of T cell receptor signaling pathway;GO:0046982,molecular_function,protein heterodimerization activity;GO:0001942,biological_process,hair follicle development;GO:0009887,biological_process,animal organ morphogenesis;GO:0033209,biological_process,tumor necrosis factor-mediated signaling pathway;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0005634,cellular_component,nucleus;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0042826,molecular_function,histone deacetylase binding;GO:0032495,biological_process,response to muramyl dipeptide;GO:0071224,biological_process,cellular response to peptidoglycan;GO:0071347,biological_process,cellular response to interleukin-1;GO:1901223,biological_process,negative regulation of NIK/NF-kappaB signaling;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0035525,cellular_component,NF-kappaB p50/p65 complex;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000980,molecular_function,RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0047485,molecular_function,protein N-terminus binding;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0070301,biological_process,cellular response to hydrogen peroxide;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0000790,cellular_component,nuclear chromatin;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity;GO:0042802,molecular_function,identical protein binding;GO:0003682,molecular_function,chromatin binding;GO:0033613,molecular_function,activating transcription factor binding;GO:1901224,biological_process,positive regulation of NIK/NF-kappaB signaling;GO:0008134,molecular_function,transcription factor binding;GO:0070555,biological_process,response to interleukin-1;GO:0003677,molecular_function,DNA binding;GO:1901522,biological_process,positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:2000630,biological_process,positive regulation of miRNA metabolic process;GO:0071532,molecular_function,ankyrin repeat binding;GO:0031490,molecular_function,chromatin DNA binding;GO:0045084,biological_process,positive regulation of interleukin-12 biosynthetic process;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0010224,biological_process,response to UV-B;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0035729,biological_process,cellular response to hepatocyte growth factor stimulus;GO:0000983,molecular_function,transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding;GO:0005829,cellular_component,cytosol;GO:0042301,molecular_function,phosphate ion binding;GO:1902895,biological_process,positive regulation of pri-miRNA transcription by RNA polymerase II;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0071354,biological_process,cellular response to interleukin-6;GO:0019899,molecular_function,enzyme binding;GO:0019221,biological_process,cytokine-mediated signaling pathway;GO:1904385,biological_process,cellular response to angiotensin;GO:0006954,biological_process,inflammatory response;GO:0042177,biological_process,negative regulation of protein catabolic process;GO:0061614,biological_process,pri-miRNA transcription by RNA polymerase II;GO:0050727,biological_process,regulation of inflammatory response;GO:1901222,biological_process,regulation of NIK/NF-kappaB signaling;GO:0001889,biological_process,liver development;GO:0006952,biological_process,defense response;GO:0070491,molecular_function,repressing transcription factor binding;GO:0070431,biological_process,nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:2001237,biological_process,negative regulation of extrinsic apoptotic signaling pathway;GO:0033234,biological_process,negative regulation of protein sumoylation;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0042805,molecular_function,actinin binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0071159,cellular_component,NF-kappaB complex;GO:0005667,cellular_component,transcription factor complex","K04735,ko05142,Chagas disease (American trypanosomiasis);K04735,ko04622,RIG-I-like receptor signaling pathway;K04735,ko05030,Cocaine addiction;K04735,ko05222,Small cell lung cancer;K04735,ko04722,Neurotrophin signaling pathway;K04735,ko04621,NOD-like receptor signaling pathway;K04735,ko05169,Epstein-Barr virus infection;K04735,ko05200,Pathways in cancer;K04735,ko04024,cAMP signaling pathway;K04735,ko04920,Adipocytokine signaling pathway;K04735,ko05140,Leishmaniasis;K04735,ko04014,Ras signaling pathway;K04735,ko05161,Hepatitis B;K04735,ko05160,Hepatitis C;K04735,ko05166,HTLV-I infection;K04735,ko04668,TNF signaling pathway;K04735,ko05134,Legionellosis;K04735,ko04662,B cell receptor signaling pathway;K04735,ko04151,PI3K-Akt signaling pathway;K04735,ko04062,Chemokine signaling pathway;K04735,ko05133,Pertussis;K04735,ko04380,Osteoclast differentiation;K04735,ko05221,Acute myeloid leukemia;K04735,ko05146,Amoebiasis;K04735,ko04066,HIF-1 signaling pathway;K04735,ko05132,Salmonella infection;K04735,ko05152,Tuberculosis;K04735,ko04623,Cytosolic DNA-sensing pathway;K04735,ko05168,Herpes simplex infection;K04735,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K04735,ko04620,Toll-like receptor signaling pathway;K04735,ko05164,Influenza A;K04735,ko04660,T cell receptor signaling pathway;K04735,ko04210,Apoptosis;K04735,ko04064,NF-kappa B signaling pathway;K04735,ko05162,Measles;K04735,ko05131,Shigellosis;K04735,ko05220,Chronic myeloid leukemia;K04735,ko05145,Toxoplasmosis;K04735,ko04932,Non-alcoholic fatty liver disease (NAFLD);K04735,ko05321,Inflammatory bowel disease (IBD);K04735,ko04010,MAPK signaling pathway;K04735,ko04071,Sphingolipid signaling pathway;K04735,ko05212,Pancreatic cancer;K04735,ko04917,Prolactin signaling pathway;K04735,ko05215,Prostate cancer;K04735,ko04931,Insulin resistance;K04735,ko04211,Longevity regulating pathway;K04735,ko04933,AGE-RAGE signaling pathway in diabetic complications;K04735,ko05203,Viral carcinogenesis;K04735,ko05202,Transcriptional misregulation in cancer"]
["COG8",7.299110506,2.375010206,1.617896063,5.208475663,{"v":4.12e-08,"d":"4.12E-08"},{"v":2.65E-7,"d":"2.65E-07"},"ENSG00000272617","B4DYU2,Conserved oligomeric Golgi complex subunit 8","-","PF04124,or1-like family","IPR007255,Conserved oligomeric Golgi complex subunit 8;IPR016632,Conserved oligomeric Golgi complex subunit 8, Metazoal and Viridiplantae;IPR016159,Cullin repeat-like-containing domain superfamily","ENOG410XNZ7,-;KOG2069,Golgi transport complex subunit","GO:0005794,cellular_component,Golgi apparatus;GO:0006891,biological_process,intra-Golgi vesicle-mediated transport;GO:0015031,biological_process,protein transport;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0017119,cellular_component,Golgi transport complex","-"]
["FAM8A1",4.315610936,1.401169318,1.617833893,3.830726314,{"v":4.91e-05,"d":"4.91E-05"},1.59612E-4,"ENSG00000137414","A0A024R006,Family with sequence similarity 8, member A1, isoform CRA_a","NP_057339.1,protein FAM8A1","PF06271,RDD family","IPR010432,RDD","ENOG4111F0T,-;KOG4647,Uncharacterized membrane protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["REPIN1",7.15087553,2.325853665,1.617267323,4.519371397,{"v":1.17E-6,"d":"1.17E-06"},{"v":5.46e-06,"d":"5.46E-06"},"ENSG00000214022","H2RDW5,Uncharacterized protein","XP_009452802.1,-;XP_003318942.1,replication initiator 1 isoform X1;XP_016813885.1,-;XP_003951233.2,-;XP_016813884.1,-;XP_009452803.1,-;XP_016813887.1,-;XP_016813886.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["NELFCD",12.29152229,4.006047201,1.616086745,5.708131603,{"v":2.6e-09,"d":"2.60E-09"},{"v":2.18E-8,"d":"2.18E-08"},"ENSG00000101158","H0UI80,Negative elongation factor C/D","NP_945327.2,negative elongation factor C/D","PF04858,TH1 protein","IPR006942,TH1 protein","ENOG410XSDJ,-;ENOG410IFGF,-","GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["LAMC2",51.71644613,16.87644521,1.615309192,7.816325176,{"v":7.07e-13,"d":"7.07E-13"},1.33E-11,"ENSG00000058085","H2Q0R2,Laminin, gamma 2","XP_009437688.2,laminin subunit gamma-2 isoform X2","PF00053,Laminin EGF domain;PF00052,Laminin B (Domain IV)","IPR031082,Laminin subunit gamma-2;IPR000034,Laminin IV;IPR002049,Laminin EGF domain;IPR000742,EGF-like domain","ENOG4110QI9,-;ENOG410IP6C,-","GO:0048731,biological_process,system development;GO:0005604,cellular_component,basement membrane;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0030335,biological_process,positive regulation of cell migration;GO:0070831,biological_process,basement membrane assembly","-"]
["ATP6V1C1",9.618536051,3.136071257,1.61503734,5.257535393,{"v":2.82e-08,"d":"2.82E-08"},{"v":1.88e-07,"d":"1.88E-07"},"ENSG00000155097","H2RD64,V-type proton ATPase subunit C","XP_009454031.1,-;XP_001155312.1,-","PF03223,V-ATPase subunit C","IPR004907,ATPase, V1 complex, subunit C;IPR036132,Vacuolar ATP synthase subunit C superfamily","COG5127,Vacuolar H+-ATPase V1 sector, subunit C;KOG2909,Vacuolar H+-ATPase V1 sector, subunit C","GO:0015991,biological_process,ATP hydrolysis coupled proton transport;GO:0000221,cellular_component,vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033180,cellular_component,proton-transporting V-type ATPase, V1 domain;GO:0015078,molecular_function,proton transmembrane transporter activity;GO:0006811,biological_process,ion transport;GO:0005886,cellular_component,plasma membrane;GO:0008553,molecular_function,proton-exporting ATPase activity, phosphorylative mechanism;GO:0046961,molecular_function,proton-transporting ATPase activity, rotational mechanism;GO:0005765,cellular_component,lysosomal membrane","K02148,ko04150,mTOR signaling pathway;K02148,ko04721,Synaptic vesicle cycle;K02148,ko05323,Rheumatoid arthritis;K02148,ko04145,Phagosome;K02148,ko04966,Collecting duct acid secretion;K02148,ko00190,Oxidative phosphorylation;K02148,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K02148,ko05110,Vibrio cholerae infection"]
["PRRT3",3.074503023,0.9982130849999999,1.614453735,3.141875261,1.04138E-3,0.00250657,"ENSG00000163704","G3R932,Proline rich transmembrane protein 3","XP_004033607.1,proline-rich transmembrane protein 3;XP_018879059.1,-;XP_018879060.1,-","-","-","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ABHD5",3.817927935,1.239584282,1.614453735,3.141875261,1.04138E-3,0.00250657,"ENSG00000011198","A0A0S2Z5D6,Abhydrolase domain containing 5 isoform 1","NP_057090.2,1-acylglycerol-3-phosphate O-acyltransferase ABHD5","PF12697,Alpha/beta hydrolase family;PF00561,alpha/beta hydrolase fold;PF12146,Serine aminopeptidase, S33","IPR000073,Alpha/beta hydrolase fold-1;IPR029058,Alpha/Beta hydrolase fold","-","GO:0006629,biological_process,lipid metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0010891,biological_process,negative regulation of sequestering of triglyceride;GO:0051006,biological_process,positive regulation of lipoprotein lipase activity;GO:0050996,biological_process,positive regulation of lipid catabolic process;GO:0005829,cellular_component,cytosol;GO:0005811,cellular_component,lipid droplet;GO:0010898,biological_process,positive regulation of triglyceride catabolic process","K13699,ko04923,Regulation of lipolysis in adipocytes"]
["KIFAP3",4.245470657,1.382268451,1.614035668,3.894467005,{"v":3.78e-05,"d":"3.78E-05"},1.26351E-4,"ENSG00000075945","H2Q0K8,Kinesin-associated protein 3","XP_513988.2,-","PF05804,Kinesin-associated protein (KAP)","IPR000225,Armadillo;IPR011989,Armadillo-like helical;IPR008658,Kinesin-associated protein 3;IPR016024,Armadillo-type fold","ENOG410XT8I,-;KOG1222,Kinesin associated protein KAP","GO:0005930,cellular_component,axoneme;GO:0000794,cellular_component,condensed nuclear chromosome;GO:0005794,cellular_component,Golgi apparatus;GO:0046587,biological_process,positive regulation of calcium-dependent cell-cell adhesion;GO:0005871,cellular_component,kinesin complex;GO:0005876,cellular_component,spindle microtubule;GO:1990075,cellular_component,periciliary membrane compartment;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0008104,biological_process,protein localization;GO:0030990,cellular_component,intraciliary transport particle;GO:0016939,cellular_component,kinesin II complex;GO:0005783,cellular_component,endoplasmic reticulum;GO:0007017,biological_process,microtubule-based process;GO:0032391,cellular_component,photoreceptor connecting cilium;GO:0036064,cellular_component,ciliary basal body;GO:0005813,cellular_component,centrosome;GO:0019894,molecular_function,kinesin binding;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["ZNF713",4.898869144,1.596800415,1.613867533,4.384726952,{"v":3.17e-06,"d":"3.17E-06"},{"v":1.34E-5,"d":"1.34E-05"},"ENSG00000178665","A0A0M3HEQ9,Zinc finger protein 713","NP_872439.2,zinc finger protein 713","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["PTOV1-AS1",4.067839748,1.325310151,1.611946976,3.605972757,0.000150034,4.37806E-4,"ENSG00000268006","M0QYH7,Prostate tumor-overexpressed gene 1 protein","-","PF11232,Mediator complex subunit 25 PTOV activation and synapsin 2","IPR038196,PTOV domain superfamily;IPR021394,Mediator complex, subunit Med25, PTOV domain","-","GO:0005634,cellular_component,nucleus","-"]
["SLC25A25",3.463762249,1.12850052,1.611946976,3.605972757,0.000150034,4.37806E-4,"ENSG00000148339","F6YJ93,Calcium-binding mitochondrial carrier protein SCaMC-2 isoform b","XP_009001655.1,calcium-binding mitochondrial carrier protein SCaMC-2 isoform X1","PF00153,Mitochondrial carrier protein;PF13499,-hand domain pair","IPR023395,Mitochondrial carrier domain superfamily;IPR002067,Mitochondrial carrier protein;IPR002048,EF-hand domain;IPR002167,Graves disease carrier protein;IPR018108,Mitochondrial substrate/solute carrier;IPR011992,EF-hand domain pair","ENOG410XQ4P,-;KOG0036,Predicted mitochondrial carrier protein","GO:0046034,biological_process,ATP metabolic process;GO:0014823,biological_process,response to activity;GO:0043010,biological_process,camera-type eye development;GO:0055085,biological_process,transmembrane transport;GO:0035264,biological_process,multicellular organism growth;GO:0005509,molecular_function,calcium ion binding;GO:0002021,biological_process,response to dietary excess;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0032094,biological_process,response to food;GO:0060612,biological_process,adipose tissue development;GO:0045333,biological_process,cellular respiration;GO:0016021,cellular_component,integral component of membrane;GO:0070588,biological_process,calcium ion transmembrane transport","-"]
["MCM3AP-AS1",4.090371996,1.335643234,1.61141231,4.428325489,{"v":2.6e-06,"d":"2.60E-06"},{"v":1.13E-5,"d":"1.13E-05"},"ENSG00000215424","B3KT88,cDNA FLJ37862 fis, clone BRSSN2015707, highly similar to 80 kDa MCM3-ASSOCIATED PROTEIN","-","PF16769,MCM3AP domain of GANP","IPR031907,Germinal-centre associated nuclear protein, MCM3AP domain","COG5079,Nuclear protein export factor;KOG1860,Nuclear protein export factor","-","-"]
["MTR",3.173372787,1.037091966,1.610644672,4.635455206,{"v":8.77e-07,"d":"8.77E-07"},{"v":4.19e-06,"d":"4.19E-06"},"ENSG00000116984","B7ZLW8,5-methyltetrahydrofolate-homocysteine methyltransferase","-","PF00809,Pterin binding enzyme;PF02574,Homocysteine S-methyltransferase;PF02607,B12 binding domain;PF02310,B12 binding domain;PF02965,Vitamin B12 dependent methionine synthase, activation domain","IPR004223,Vitamin B12-dependent methionine synthase, activation domain;IPR006158,Cobalamin (vitamin B12)-binding domain;IPR033706,Methionine synthase, B12-binding domain;IPR000489,Pterin-binding domain;IPR003726,Homocysteine-binding domain;IPR036724,Cobalamin-binding domain superfamily;IPR037010,Vitamin B12-dependent methionine synthase, activation domain superfamily;IPR003759,Cobalamin (vitamin B12)-binding module, cap domain;IPR011005,Dihydropteroate synthase-like;IPR011822,Cobalamin-dependent methionine synthase;IPR036589,Homocysteine-binding domain superfamily;IPR036594,Methionine synthase domain","COG1410,Methionine synthase I, cobalamin-binding domain;KOG1579,Homocysteine S-methyltransferase;COG0646,Methionine synthase I (cobalamin-dependent), methyltransferase domain","GO:0042558,biological_process,pteridine-containing compound metabolic process;GO:0008652,biological_process,cellular amino acid biosynthetic process;GO:0031419,molecular_function,cobalamin binding;GO:0008705,molecular_function,methionine synthase activity;GO:0044237,biological_process,cellular metabolic process;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0009086,biological_process,methionine biosynthetic process;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0008270,molecular_function,zinc ion binding","-"]
["CDC37L1",5.59224956,1.825423092,1.610572391,3.955488088,{"v":2.93e-05,"d":"2.93E-05"},{"v":9.98E-5,"d":"9.98E-05"},"ENSG00000106993","H2R6U4,Cell division cycle 37 homolog-like 1","XP_528531.2,hsp90 co-chaperone Cdc37-like 1","PF08565,Cdc37 Hsp90 binding domain","IPR038189,Cdc37, Hsp90-binding domain superfamily;IPR013874,Cdc37, Hsp90 binding;IPR004918,Cdc37","KOG2260,Cell division cycle 37 protein, CDC37;ENOG410XTCZ,-","GO:0050821,biological_process,protein stabilization;GO:0051087,molecular_function,chaperone binding;GO:0005737,cellular_component,cytoplasm;GO:0006457,biological_process,protein folding;GO:0051082,molecular_function,unfolded protein binding;GO:0051301,biological_process,cell division;GO:0005829,cellular_component,cytosol;GO:0031072,molecular_function,heat shock protein binding","-"]
["SRGAP2D",7.907585641,2.567392322,1.610250361,2.610541143,5.100126E-3,0.010435643,"ENSG00000270872","A0A286YEY3,SLIT-ROBO Rho GTPase-activating protein 2B","NP_001258799.2,SLIT-ROBO Rho GTPase-activating protein 2B isoform 1","-","IPR031160,F-BAR domain;IPR001060,FCH domain;IPR027267,AH/BAR domain superfamily;IPR030252,SLIT-ROBO Rho GTPase-activating protein 2","-","-","-"]
["ZNF26",0.386983892,0.125643846,1.610250361,2.610541143,5.100126E-3,0.010435643,"ENSG00000198393","V9HW07,Epididymis luminal protein 179","NP_001317442.1,-;NP_001317443.1,zinc finger protein 26 isoform 4;NP_062537.2,zinc finger protein 26 isoform 2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["THAP1",3.279303387,1.064706564,1.610250361,2.610541143,5.100126E-3,0.010435643,"ENSG00000131931","A0A0D9RR28,THAP domain containing 1","XP_007960538.1,-","PF05485,THAP domain","IPR038441,THAP-type zinc finger superfamily;IPR026516,THAP domain-containing protein 1;IPR006612,THAP-type zinc finger","-","GO:0007346,biological_process,regulation of mitotic cell cycle;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001650,cellular_component,fibrillar center;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0006351,biological_process,transcription, DNA-templated;GO:0001935,biological_process,endothelial cell proliferation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["YES1",34.12907578,11.17910577,1.609611098,6.864415923,{"v":1.82e-11,"d":"1.82E-11"},{"v":2.48e-10,"d":"2.48E-10"},"ENSG00000176105","J3QRU1,Tyrosine-protein kinase","-","PF00018,SH3 domain;PF00017,SH2 domain;PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR036860,SH2 domain superfamily;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR000980,SH2 domain;IPR011009,Protein kinase-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR001452,SH3 domain;IPR035751,Tyrosine-protein kinase Yes, SH3 domain;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0197,Tyrosine kinases","GO:0016301,molecular_function,kinase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004715,molecular_function,non-membrane spanning protein tyrosine kinase activity;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation","-"]
["CLPTM1",35.19441817,11.52994337,1.6094076,6.944211309,{"v":1.17e-11,"d":"1.17E-11"},1.65E-10,"ENSG00000104853","K7BI94,Cleft lip and palate associated transmembrane protein 1","XP_001162487.2,cleft lip and palate transmembrane protein 1 isoform X1","PF05602,Cleft lip and palate transmembrane protein 1 (CLPTM1)","IPR008429,Cleft lip and palate transmembrane 1","ENOG410XPEV,-;KOG2489,Transmembrane protein","GO:0009897,cellular_component,external side of plasma membrane;GO:0033081,biological_process,regulation of T cell differentiation in thymus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["FASN",41.10667402,13.47185245,1.609159818,8.002996408,{"v":5.84e-13,"d":"5.84E-13"},{"v":1.12e-11,"d":"1.12E-11"},"ENSG00000169710","A0A0U1RQF0,Fatty acid synthase","-","PF08659,KR domain;PF13602,Zinc-binding dehydrogenase;PF02801,Beta-ketoacyl synthase, C-terminal domain;PF00975,Thioesterase domain;PF16197,Ketoacyl-synthetase C-terminal extension;PF14765,Polyketide synthase dehydratase;PF00698,Acyl transferase domain;PF00109,Beta-ketoacyl synthase, N-terminal domain;PF00107,Zinc-binding dehydrogenase;PF00550,Phosphopantetheine attachment site","IPR020843,Polyketide synthase, enoylreductase domain;IPR013149,Alcohol dehydrogenase, C-terminal;IPR016036,Malonyl-CoA ACP transacylase, ACP-binding;IPR013968,Polyketide synthase, ketoreductase domain;IPR032821,Ketoacyl-synthetase, C-terminal extension;IPR011032,GroES-like superfamily;IPR014043,Acyl transferase;IPR020841,Polyketide synthase, beta-ketoacyl synthase domain;IPR016039,Thiolase-like;IPR016035,Acyl transferase/acyl hydrolase/lysophospholipase;IPR020807,Polyketide synthase, dehydratase domain;IPR020806,Polyketide synthase, phosphopantetheine-binding domain;IPR036736,ACP-like superfamily;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR023102,Fatty acid synthase, domain 2;IPR020801,Polyketide synthase, acyl transferase domain;IPR001227,Acyl transferase domain superfamily;IPR001031,Thioesterase;IPR014031,Beta-ketoacyl synthase, C-terminal;IPR014030,Beta-ketoacyl synthase, N-terminal;IPR036291,NAD(P)-binding domain superfamily;IPR018201,Beta-ketoacyl synthase, active site;IPR006162,Phosphopantetheine attachment site;IPR009081,Phosphopantetheine binding ACP domain;IPR029058,Alpha/Beta hydrolase fold","-","GO:0004320,molecular_function,oleoyl-[acyl-carrier-protein] hydrolase activity;GO:0016295,molecular_function,myristoyl-[acyl-carrier-protein] hydrolase activity;GO:0004315,molecular_function,3-oxoacyl-[acyl-carrier-protein] synthase activity;GO:0005886,cellular_component,plasma membrane;GO:0004314,molecular_function,[acyl-carrier-protein] S-malonyltransferase activity;GO:0004313,molecular_function,[acyl-carrier-protein] S-acetyltransferase activity;GO:0005794,cellular_component,Golgi apparatus;GO:0003824,molecular_function,catalytic activity;GO:0016296,molecular_function,palmitoyl-[acyl-carrier-protein] hydrolase activity;GO:0004312,molecular_function,fatty acid synthase activity;GO:0009058,biological_process,biosynthetic process;GO:0005829,cellular_component,cytosol;GO:0016297,molecular_function,acyl-[acyl-carrier-protein] hydrolase activity;GO:0004316,molecular_function,3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity;GO:0031177,molecular_function,phosphopantetheine binding;GO:0016740,molecular_function,transferase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0008152,biological_process,metabolic process;GO:0004319,molecular_function,enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity;GO:0016788,molecular_function,hydrolase activity, acting on ester bonds;GO:0055114,biological_process,oxidation-reduction process;GO:0004317,molecular_function,3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity","-"]
["DNAJC13",10.87717461,3.563794006,1.608838878,6.129484488,{"v":3.69e-10,"d":"3.69E-10"},{"v":3.75e-09,"d":"3.75E-09"},"ENSG00000138246","H2PBG0,DnaJ heat shock protein family","XP_002814100.1,dnaJ homolog subfamily C member 13 isoform X2;XP_009237597.1,-","PF14237,omain of unknown function (DUF4339);PF00226,naJ domain","IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR036869,Chaperone J-domain superfamily;IPR025640,Domain of unknown function DUF4339;IPR001623,DnaJ domain","ENOG410XRI2,-;KOG1789,Endocytosis protein RME-8, contains DnaJ domain","GO:2000641,biological_process,regulation of early endosome to late endosome transport;GO:0007032,biological_process,endosome organization;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:1902954,biological_process,regulation of early endosome to recycling endosome transport;GO:0005829,cellular_component,cytosol;GO:0010008,cellular_component,endosome membrane;GO:0031901,cellular_component,early endosome membrane;GO:0071203,cellular_component,WASH complex","-"]
["PCTP",2.221140815,0.724425984,1.608576869,3.24384004,0.000543102,0.001396412,"ENSG00000141179","I3L3H0,Phosphatidylcholine transfer protein","NP_001317307.1,phosphatidylcholine transfer protein isoform 4","PF01852,START domain","IPR023393,START-like domain superfamily;IPR002913,START domain","KOG2761,START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer;ENOG4111HC0,-","GO:0008289,molecular_function,lipid binding","-"]
["SLC35B2",5.527002958,1.802634273,1.608576869,3.24384004,0.000543102,0.001396412,"ENSG00000157593","K7DG79,Solute carrier family 35, member B2","XP_016811103.1,-","PF08449,UAA transporter family","IPR013657,UAA transporter","-","GO:0005794,cellular_component,Golgi apparatus;GO:0055085,biological_process,transmembrane transport;GO:1902559,biological_process,3'-phospho-5'-adenylyl sulfate transmembrane transport;GO:0046964,molecular_function,3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity;GO:0046963,biological_process,3'-phosphoadenosine 5'-phosphosulfate transport;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["DDX20",2.998333783,0.979887359,1.607827071,3.680303699,{"v":8.54e-05,"d":"8.54E-05"},0.000261856,"ENSG00000064703","Q8IYV2,DEAD","-","PF00271,Helicase conserved C-terminal domain;PF00270,AD/DEAH box helicase","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR014014,RNA helicase, DEAD-box type, Q motif;IPR011545,DEAD/DEAH box helicase domain;IPR000629,ATP-dependent RNA helicase DEAD-box, conserved site;IPR001650,Helicase, C-terminal","KOG4284,DEAD box protein;COG0513,Superfamily II DNA and RNA helicases","GO:0003676,molecular_function,nucleic acid binding;GO:0005524,molecular_function,ATP binding","-"]
["METTL13",4.71569664,1.541139799,1.607827071,3.680303699,{"v":8.54e-05,"d":"8.54E-05"},0.000261856,"ENSG00000010165","C4B4C6,Antiapoptotic protein FEAT","NP_057019.3,methyltransferase-like protein 13 isoform 1","PF08241,Methyltransferase domain;PF13649,Methyltransferase domain;PF13847,Methyltransferase domain;PF01564,Spermine/spermidine synthase domain","IPR013216,Methyltransferase type 11;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase","KOG2352,Predicted spermine/spermidine synthase;ENOG410XNZZ,-","GO:0032259,biological_process,methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0008152,biological_process,metabolic process","-"]
["TUSC3",11.94163736,3.91428393,1.607539041,5.39541851,{"v":1.59E-8,"d":"1.59E-08"},{"v":1.12E-7,"d":"1.12E-07"},"ENSG00000104723","H2RDL6,Tumor suppressor candidate 3","XP_016814608.1,-;XP_009453114.1,-","PF04756,OST3 / OST6 family, transporter family","IPR021149,Oligosaccharyl transferase complex, subunit OST3/OST6;IPR036249,Thioredoxin-like superfamily","KOG2603,Oligosaccharyltransferase, gamma subunit;ENOG410XR1F,-","GO:0015095,molecular_function,magnesium ion transmembrane transporter activity;GO:1903830,biological_process,magnesium ion transmembrane transport;GO:0008250,cellular_component,oligosaccharyltransferase complex;GO:0015693,biological_process,magnesium ion transport;GO:0050890,biological_process,cognition;GO:0018279,biological_process,protein N-linked glycosylation via asparagine;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0004579,molecular_function,dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["TNPO2",4.695825892,1.538326033,1.606936114,4.511740086,{"v":1.45e-06,"d":"1.45E-06"},{"v":6.63E-6,"d":"6.63E-06"},"ENSG00000105576","K7CG87,Transportin 2","XP_009433051.1,-;XP_003316182.1,-;XP_009433053.1,-","PF13513,HEAT-like repeat;PF03810,Importin-beta N-terminal domain","IPR016024,Armadillo-type fold;IPR001494,Importin-beta, N-terminal domain","KOG2023,Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily);ENOG410XPK2,-","GO:0008536,molecular_function,Ran GTPase binding;GO:0005634,cellular_component,nucleus;GO:0006886,biological_process,intracellular protein transport","-"]
["ZDHHC12",14.62981257,4.794459343,1.606794955,4.707940517,{"v":5.17e-07,"d":"5.17E-07"},{"v":2.6e-06,"d":"2.60E-06"},"ENSG00000160446","Q5T269,Palmitoyltransferase","-","PF01529,HHC palmitoyltransferase","IPR001594,Palmitoyltransferase, DHHC domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0019706,molecular_function,protein-cysteine S-palmitoyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane","-"]
["ERRFI1",18.83343723,6.183806059,1.605441988,5.736517071,{"v":2.55e-09,"d":"2.55E-09"},{"v":2.14E-8,"d":"2.14E-08"},"ENSG00000116285","I6S2Y9,ERBB receptor feedback inhibitor 1","NP_061821.1,ERBB receptor feedback inhibitor 1;XP_006710760.1,-","PF11555,R receptor inhibitor Mig-6","IPR021619,Mig-6 domain","ENOG410IEVS,-;ENOG4111HB5,-","GO:0050732,biological_process,negative regulation of peptidyl-tyrosine phosphorylation;GO:0061469,biological_process,regulation of type B pancreatic cell proliferation;GO:0007175,biological_process,negative regulation of epidermal growth factor-activated receptor activity;GO:0042536,biological_process,negative regulation of tumor necrosis factor biosynthetic process;GO:0005886,cellular_component,plasma membrane;GO:0045616,biological_process,regulation of keratinocyte differentiation;GO:0031267,molecular_function,small GTPase binding;GO:0005737,cellular_component,cytoplasm;GO:1903243,biological_process,negative regulation of cardiac muscle hypertrophy in response to stress;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0017124,molecular_function,SH3 domain binding;GO:0019900,molecular_function,kinase binding;GO:0071549,biological_process,cellular response to dexamethasone stimulus;GO:0005829,cellular_component,cytosol;GO:0032966,biological_process,negative regulation of collagen biosynthetic process;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:0032691,biological_process,negative regulation of interleukin-1 beta production;GO:0048286,biological_process,lung alveolus development;GO:0042059,biological_process,negative regulation of epidermal growth factor receptor signaling pathway;GO:0071474,biological_process,cellular hyperosmotic response;GO:0036120,biological_process,cellular response to platelet-derived growth factor stimulus;GO:0032869,biological_process,cellular response to insulin stimulus;GO:0060426,biological_process,lung vasculature development;GO:0043589,biological_process,skin morphogenesis;GO:0060428,biological_process,lung epithelium development;GO:0031234,cellular_component,extrinsic component of cytoplasmic side of plasma membrane","-"]
["RAD23B",107.3330147,35.28683255,1.60468741,8.366725716,{"v":3.15e-13,"d":"3.15E-13"},{"v":6.46e-12,"d":"6.46E-12"},"ENSG00000119318","G3QJ86,RAD23 homolog B, nucleotide excision repair protein","XP_018889482.1,-","PF09280,XPC-binding domain;PF00627,UBA/TS-N domain;PF00240,Ubiquitin family","IPR036353,XPC-binding domain superfamily;IPR006636,Heat shock chaperonin-binding;IPR009060,UBA-like superfamily;IPR015940,Ubiquitin-associated domain;IPR004806,UV excision repair protein Rad23;IPR000626,Ubiquitin domain;IPR015360,XPC-binding domain;IPR029071,Ubiquitin-like domain superfamily","-","GO:0007283,biological_process,spermatogenesis;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0071942,cellular_component,XPC complex;GO:0003684,molecular_function,damaged DNA binding;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0005634,cellular_component,nucleus;GO:0000715,biological_process,nucleotide-excision repair, DNA damage recognition;GO:0032434,biological_process,regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006289,biological_process,nucleotide-excision repair;GO:0005829,cellular_component,cytosol;GO:0031593,molecular_function,polyubiquitin modification-dependent protein binding;GO:0005654,cellular_component,nucleoplasm","-"]
["PLK2",41.18698409,13.53810794,1.604646115,7.038358026,{"v":1.09e-11,"d":"1.09E-11"},{"v":1.55e-10,"d":"1.55E-10"},"ENSG00000145632","G3RAD3,Serine/threonine-protein kinase PLK","XP_004058871.1,-","PF00069,Protein kinase domain;PF00659,POLO box duplicated region","IPR036947,POLO box domain superfamily;IPR033701,First polo-box domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000959,POLO box domain;IPR033695,Second polo-box domain;IPR000719,Protein kinase domain","-","GO:0090050,biological_process,positive regulation of cell migration involved in sprouting angiogenesis;GO:0000785,cellular_component,chromatin;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding;GO:0043008,molecular_function,ATP-dependent protein binding;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0016301,molecular_function,kinase activity;GO:0045732,biological_process,positive regulation of protein catabolic process;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0048167,biological_process,regulation of synaptic plasticity;GO:0016310,biological_process,phosphorylation;GO:0000082,biological_process,G1/S transition of mitotic cell cycle;GO:0046599,biological_process,regulation of centriole replication;GO:0005813,cellular_component,centrosome;GO:0000278,biological_process,mitotic cell cycle;GO:0007093,biological_process,mitotic cell cycle checkpoint;GO:0010508,biological_process,positive regulation of autophagy;GO:2000773,biological_process,negative regulation of cellular senescence;GO:0005814,cellular_component,centriole;GO:0016740,molecular_function,transferase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0071866,biological_process,negative regulation of apoptotic process in bone marrow;GO:0007613,biological_process,memory;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0007052,biological_process,mitotic spindle organization","K08861,ko04068,FoxO signaling pathway"]
["GRAMD1A",4.036262988,1.323447102,1.604487784,4.070239197,{"v":2.3E-5,"d":"2.30E-05"},{"v":8.05e-05,"d":"8.05E-05"},"ENSG00000089351","M0QZ12,GRAM domain-containing protein 1A","XP_016882524.1,GRAM domain-containing protein 1A isoform X3","PF02893,RAM domain;PF16016,omain of unknown function (DUF4782)","IPR004182,GRAM domain;IPR031968,VASt domain;IPR011993,PH-like domain superfamily","ENOG410XRQQ,-;KOG1032,Uncharacterized conserved protein, contains GRAM domain","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RBM4B",4.392326387,1.439446348,1.604128447,3.750956131,1.0848E-4,0.000325887,"ENSG00000173914","G7PP84,RNA-binding motif protein 4B","XP_005577198.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF00098,Zinc knuckle","IPR034898,RBM4, RNA recognition motif 2;IPR001878,Zinc finger, CCHC-type;IPR034897,RBM4, RNA recognition motif 1;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily","-","GO:0043153,biological_process,entrainment of circadian clock by photoperiod;GO:0010628,biological_process,positive regulation of gene expression;GO:0032922,biological_process,circadian regulation of gene expression;GO:0032991,cellular_component,protein-containing complex;GO:0003676,molecular_function,nucleic acid binding;GO:0003723,molecular_function,RNA binding;GO:0007623,biological_process,circadian rhythm;GO:0006417,biological_process,regulation of translation;GO:0005829,cellular_component,cytosol;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["TBCCD1",5.579092988,1.828371647,1.604128447,3.750956131,1.0848E-4,0.000325887,"ENSG00000113838","K7CU12,TBCC domain containing 1","XP_009445256.2,-;XP_003310207.2,-;XP_516930.3,-","PF07986,Tubulin binding cofactor C","IPR016098,Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal;IPR017901,C-CAP/cofactor C-like domain;IPR006599,CARP motif;IPR012945,Tubulin binding cofactor C-like domain;IPR036223,Adenylate cyclase-associated CAP, C-terminal  superfamily","KOG4416,Uncharacterized conserved protein;ENOG410XRXF,-","GO:0051684,biological_process,maintenance of Golgi location;GO:0051661,biological_process,maintenance of centrosome location;GO:0030334,biological_process,regulation of cell migration;GO:0008360,biological_process,regulation of cell shape;GO:0031616,cellular_component,spindle pole centrosome","-"]
["ASXL1",9.067390781,2.980649067,1.603878947,5.855742218,{"v":1.73E-9,"d":"1.73E-09"},{"v":1.51E-8,"d":"1.51E-08"},"ENSG00000171456","K7B6S8,Additional sex combs like 1","-","PF13919,Asx homology domain;PF05066,HB1, ASXL, restriction endonuclease HTH domain;PF13922,PHD domain of transcriptional enhancer, Asx","IPR028020,ASX homology domain;IPR026905,Protein ASX-like, PHD domain;IPR024815,ASX-like protein 1;IPR007759,HB1/Asxl, restriction endonuclease HTH domain;IPR024811,Polycomb protein ASX/ASX-like","ENOG410YF2J,-;ENOG410IGAP,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0006351,biological_process,transcription, DNA-templated","-"]
["CASP4",18.52293857,6.09627413,1.602560564,6.496542118,{"v":9.25e-11,"d":"9.25E-11"},{"v":1.06e-09,"d":"1.06E-09"},"ENSG00000196954","H2R132,Caspase 4","XP_009422361.1,caspase-4 isoform X2","PF00619,Caspase recruitment domain;PF00656,Caspase domain","IPR016129,Peptidase family C14A, His active site;IPR001315,CARD domain;IPR011029,Death-like domain superfamily;IPR002138,Peptidase C14, caspase non-catalytic subunit p10;IPR001309,Peptidase C14,  p20 domain;IPR015917,Peptidase C14A, caspase catalytic domain;IPR029030,Caspase-like domain superfamily;IPR033139,Peptidase family C14A, cysteine active site","ENOG410ZQIE,-;KOG3573,Caspase, apoptotic cysteine protease","GO:0032991,cellular_component,protein-containing complex;GO:0097169,cellular_component,AIM2 inflammasome complex;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005886,cellular_component,plasma membrane;GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:1904646,biological_process,cellular response to amyloid-beta;GO:0005739,cellular_component,mitochondrion;GO:0005829,cellular_component,cytosol;GO:0097193,biological_process,intrinsic apoptotic signaling pathway;GO:0050700,molecular_function,CARD domain binding;GO:0008233,molecular_function,peptidase activity;GO:0042981,biological_process,regulation of apoptotic process;GO:0097194,biological_process,execution phase of apoptosis;GO:0072557,cellular_component,IPAF inflammasome complex;GO:1903265,biological_process,positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0072559,cellular_component,NLRP3 inflammasome complex;GO:0050727,biological_process,regulation of inflammatory response;GO:0097153,molecular_function,cysteine-type endopeptidase activity involved in apoptotic process;GO:0070059,biological_process,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0004197,molecular_function,cysteine-type endopeptidase activity;GO:0097200,molecular_function,cysteine-type endopeptidase activity involved in execution phase of apoptosis","-"]
["FASTKD2",1.484370048,0.485107913,1.602224307,2.75653886,0.003394765,0.007241775,"ENSG00000118246","A0A024R419,KIAA0971, isoform CRA_b","NP_001129665.1,-;NP_055744.2,FAST kinase domain-containing protein 2, mitochondrial;NP_001129666.1,-","PF08373,RAP domain;PF06743,AST kinase-like protein, subdomain 1;PF08368,AST kinase-like protein, subdomain 2","IPR013579,FAST kinase-like protein, subdomain 2;IPR010622,FAST kinase leucine-rich;IPR013584,RAP domain","ENOG410IH1K,-;ENOG410ZQHV,-","GO:0004672,molecular_function,protein kinase activity;GO:0045171,cellular_component,intercellular bridge;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0005739,cellular_component,mitochondrion","-"]
["MVB12B",1.144531395,0.374045029,1.602224307,2.75653886,0.003394765,0.007241775,"ENSG00000196814","H2QXW5,Family with sequence similarity 125, member B","-","PF10240,Multivesicular body subunit 12","IPR023340,UMA domain;IPR018798,Multivesicular body subunit 12;IPR023341,MABP domain","KOG4000,Uncharacterized conserved protein;ENOG4110KHY,-","GO:0005770,cellular_component,late endosome;GO:0000813,cellular_component,ESCRT I complex;GO:0005634,cellular_component,nucleus;GO:0042058,biological_process,regulation of epidermal growth factor receptor signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0005769,cellular_component,early endosome;GO:0048524,biological_process,positive regulation of viral process;GO:0005829,cellular_component,cytosol;GO:0031982,cellular_component,vesicle;GO:0019075,biological_process,virus maturation;GO:0008289,molecular_function,lipid binding","-"]
["LRIF1",12.65667165,4.162529266,1.602158017,4.971612219,{"v":1.7e-07,"d":"1.70E-07"},{"v":9.45e-07,"d":"9.45E-07"},"ENSG00000121931","G3QWE2,Ligand dependent nuclear receptor interacting factor 1","XP_018872054.1,ligand-dependent nuclear receptor-interacting factor 1 isoform X3","PF15741,Ligand-dependent nuclear receptor-interacting factor 1","IPR026191,Ligand-dependent nuclear receptor-interacting factor 1","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0042974,molecular_function,retinoic acid receptor binding","-"]
["RUFY1",24.74631188,8.148625685,1.601893705,6.61761722,{"v":5.78e-11,"d":"5.78E-11"},{"v":6.94e-10,"d":"6.94E-10"},"ENSG00000176783","G1QLD6,RUN and FYVE domain containing 1","-","PF01363,YVE zinc finger;PF02759,RUN domain","IPR017455,Zinc finger, FYVE-related;IPR011011,Zinc finger, FYVE/PHD-type;IPR004012,RUN domain;IPR000306,FYVE zinc finger;IPR037213,RUN domain superfamily;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG1729,FYVE finger containing protein;KOG4381,RUN domain-containing protein;ENOG410XRAX,-","GO:0030100,biological_process,regulation of endocytosis;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0042169,molecular_function,SH2 domain binding;GO:0005768,cellular_component,endosome;GO:0046872,molecular_function,metal ion binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0017124,molecular_function,SH3 domain binding;GO:0016607,cellular_component,nuclear speck;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0008565,molecular_function,protein transporter activity","-"]
["ZYG11B",2.433112003,0.799374104,1.600789618,3.818278676,{"v":6.36e-05,"d":"6.36E-05"},0.000201414,"ENSG00000162378","H2N7D5,Zyg-11 family member B, cell cycle regulator","XP_009248536.1,-","-","IPR001611,Leucine-rich repeat;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR032675,Leucine-rich repeat domain superfamily","ENOG410XPSX,-;KOG3665,ZYG-1-like serine/threonine protein kinases","-","-"]
["EFNA1",12.15825872,4.000617092,1.600369387,4.420185986,{"v":3.23E-6,"d":"3.23E-06"},{"v":1.37e-05,"d":"1.37E-05"},"ENSG00000169242","H2Q067,Uncharacterized protein","XP_001141980.2,-","PF00812,phrin","IPR001799,Ephrin receptor-binding domain;IPR008972,Cupredoxin;IPR034252,Ephrin-A ectodomain;IPR019765,Ephrin, conserved site;IPR031328,Ephrin","ENOG4111FMJ,-;KOG3858,Ephrin, ligand for Eph receptor tyrosine kinase","GO:0050770,biological_process,regulation of axonogenesis;GO:0014028,biological_process,notochord formation;GO:0050730,biological_process,regulation of peptidyl-tyrosine phosphorylation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0070244,biological_process,negative regulation of thymocyte apoptotic process;GO:1903051,biological_process,negative regulation of proteolysis involved in cellular protein catabolic process;GO:0030182,biological_process,neuron differentiation;GO:0045765,biological_process,regulation of angiogenesis;GO:0043535,biological_process,regulation of blood vessel endothelial cell migration;GO:0061002,biological_process,negative regulation of dendritic spine morphogenesis;GO:0046875,molecular_function,ephrin receptor binding;GO:0061098,biological_process,positive regulation of protein tyrosine kinase activity;GO:0007411,biological_process,axon guidance;GO:0010719,biological_process,negative regulation of epithelial to mesenchymal transition;GO:1902961,biological_process,positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:1902004,biological_process,positive regulation of amyloid-beta formation;GO:0001525,biological_process,angiogenesis;GO:0016020,cellular_component,membrane;GO:0003199,biological_process,endocardial cushion to mesenchymal transition involved in heart valve formation;GO:0034446,biological_process,substrate adhesion-dependent cell spreading;GO:0048013,biological_process,ephrin receptor signaling pathway;GO:0050821,biological_process,protein stabilization;GO:0043409,biological_process,negative regulation of MAPK cascade;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0003180,biological_process,aortic valve morphogenesis;GO:0043410,biological_process,positive regulation of MAPK cascade;GO:0046658,cellular_component,anchored component of plasma membrane;GO:0016477,biological_process,cell migration;GO:0003183,biological_process,mitral valve morphogenesis;GO:0033628,biological_process,regulation of cell adhesion mediated by integrin;GO:0001934,biological_process,positive regulation of protein phosphorylation","K05462,ko04360,Axon guidance;K05462,ko04151,PI3K-Akt signaling pathway;K05462,ko04014,Ras signaling pathway;K05462,ko04015,Rap1 signaling pathway"]
["SAPCD2",32.02749881,10.55880124,1.600046281,6.373429041,1.65E-10,{"v":1.8E-9,"d":"1.80E-09"},"ENSG00000186193","A0A024R8I8,Chromosome 9 open reading frame 140, isoform CRA_a","-","PF11414,Adenomatous polyposis coli tumour suppressor protein","IPR026828,Suppressor APC domain-containing protein 1/2","ENOG410INQN,-;ENOG4110P7W,-","-","-"]
["CCT3",146.8021406,48.44004141,1.599430071,8.619261504,{"v":2.44e-13,"d":"2.44E-13"},{"v":5.16e-12,"d":"5.16E-12"},"ENSG00000163468","Q59H77,T-complex protein 1 subunit gamma","NP_005989.3,T-complex protein 1 subunit gamma isoform a","PF00118,TCP-1/cpn60 chaperonin family","IPR017998,Chaperone tailless complex polypeptide 1 (TCP-1);IPR027413,GroEL-like equatorial domain superfamily;IPR012719,T-complex protein 1, gamma subunit;IPR027409,GroEL-like apical domain superfamily;IPR027410,TCP-1-like chaperonin intermediate domain superfamily;IPR002423,Chaperonin Cpn60/TCP-1 family;IPR002194,Chaperonin TCP-1, conserved site","COG0459,Chaperonin GroEL (HSP60 family);KOG0364,Chaperonin complex component, TCP-1 gamma subunit (CCT3)","GO:0006457,biological_process,protein folding;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0051082,molecular_function,unfolded protein binding","-"]
["PLEKHG3",10.50726252,3.466464658,1.59904436,6.3954942,{"v":1.4e-10,"d":"1.40E-10"},{"v":1.54e-09,"d":"1.54E-09"},"ENSG00000126822","G3R1T3,Pleckstrin homology and RhoGEF domain containing G3","XP_004055347.2,pleckstrin homology domain-containing family G member 3 isoform X5","PF00621,RhoGEF domain;PF00169,PH domain","IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR001849,Pleckstrin homology domain;IPR035899,Dbl homology (DH) domain superfamily","-","GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0065009,biological_process,regulation of molecular function","-"]
["POLR3A",3.568426541,1.175869714,1.598391376,4.462739155,{"v":2.15e-06,"d":"2.15E-06"},{"v":9.48e-06,"d":"9.48E-06"},"ENSG00000148606","K7D6W6,DNA-directed RNA polymerase subunit","XP_016774210.1,DNA-directed RNA polymerase III subunit RPC1 isoform X1","PF04997,RNA polymerase Rpb1, domain 1;PF04983,RNA polymerase Rpb1, domain 3;PF04998,RNA polymerase Rpb1, domain 5;PF05000,RNA polymerase Rpb1, domain 4;PF00623,RNA polymerase Rpb1, domain 2","IPR007081,RNA polymerase Rpb1, domain 5;IPR007080,RNA polymerase Rpb1, domain 1;IPR038120,RNA polymerase Rpb1, funnel domain superfamily;IPR035697,DNA-directed RNA polymerase III subunit RPC1, N-terminal;IPR006592,RNA polymerase, N-terminal;IPR007066,RNA polymerase Rpb1, domain 3;IPR035698,DNA-directed RNA polymerase III subunit RPC1, C-terminal;IPR007083,RNA polymerase Rpb1, domain 4;IPR000722,RNA polymerase, alpha subunit","KOG0260,RNA polymerase II, large subunit;COG0086,DNA-directed RNA polymerase, beta' subunit/160 kD subunit","GO:0032728,biological_process,positive regulation of interferon-beta production;GO:0003677,molecular_function,DNA binding;GO:0045087,biological_process,innate immune response;GO:0016740,molecular_function,transferase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0005666,cellular_component,DNA-directed RNA polymerase III complex;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","K03018,ko03020,RNA polymerase;K03018,ko05169,Epstein-Barr virus infection;K03018,ko04623,Cytosolic DNA-sensing pathway;K03018,ko00230,Purine metabolism;K03018,ko00240,Pyrimidine metabolism"]
["DOCK7",1.957194025,0.645525443,1.598171076,5.057272589,{"v":1.18E-7,"d":"1.18E-07"},{"v":6.83e-07,"d":"6.83E-07"},"ENSG00000116641","U3D9V6,Dedicator of cytokinesis protein 7 isoform 1","-","PF06920,ock homology region 2;PF14429,C2 domain in Dock180 and Zizimin proteins;PF11878,omain of unknown function (DUF3398)","IPR037808,Dedicator of cytokinesis C, C2 domain;IPR010703,Dedicator of cytokinesis, C-terminal;IPR035892,C2 domain superfamily;IPR021816,Dedicator of cytokinesis C/D, N-terminal;IPR027007,DHR-1 domain;IPR027357,DHR-2 domain;IPR026791,Dedicator of cytokinesis","ENOG410XNVY,-;KOG1997,PH domain-containing protein","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005622,cellular_component,intracellular","-"]
["GCLC",6.453483802,2.12944458,1.597757076,5.219324298,{"v":5.04e-08,"d":"5.04E-08"},{"v":3.17e-07,"d":"3.17E-07"},"ENSG00000001084","Q14TF0,Glutamate-cysteine ligase","NP_001184044.1,glutamate--cysteine ligase catalytic subunit isoform b;NP_001489.1,glutamate--cysteine ligase catalytic subunit isoform a","PF03074,lutamate-cysteine ligase","IPR014746,Glutamine synthetase/guanido kinase, catalytic domain;IPR004308,Glutamate-cysteine ligase catalytic subunit","ENOG410XQIG,-;KOG3754,Gamma-glutamylcysteine synthetase","GO:0007584,biological_process,response to nutrient;GO:0044344,biological_process,cellular response to fibroblast growth factor stimulus;GO:0014823,biological_process,response to activity;GO:0031397,biological_process,negative regulation of protein ubiquitination;GO:0006749,biological_process,glutathione metabolic process;GO:0017109,cellular_component,glutamate-cysteine ligase complex;GO:0035729,biological_process,cellular response to hepatocyte growth factor stimulus;GO:0071260,biological_process,cellular response to mechanical stimulus;GO:0016874,molecular_function,ligase activity;GO:0046982,molecular_function,protein heterodimerization activity;GO:0071372,biological_process,cellular response to follicle-stimulating hormone stimulus;GO:0032436,biological_process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0051409,biological_process,response to nitrosative stress;GO:0003824,molecular_function,catalytic activity;GO:0008637,biological_process,apoptotic mitochondrial changes;GO:0046685,biological_process,response to arsenic-containing substance;GO:0019852,biological_process,L-ascorbic acid metabolic process;GO:0097069,biological_process,cellular response to thyroxine stimulus;GO:2000490,biological_process,negative regulation of hepatic stellate cell activation;GO:0006979,biological_process,response to oxidative stress;GO:0005829,cellular_component,cytosol;GO:0006750,biological_process,glutathione biosynthetic process;GO:0009410,biological_process,response to xenobiotic stimulus;GO:0032869,biological_process,cellular response to insulin stimulus;GO:0071333,biological_process,cellular response to glucose stimulus;GO:0004357,molecular_function,glutamate-cysteine ligase activity;GO:0051900,biological_process,regulation of mitochondrial depolarization;GO:0044752,biological_process,response to human chorionic gonadotropin;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0046686,biological_process,response to cadmium ion;GO:0070555,biological_process,response to interleukin-1;GO:2001237,biological_process,negative regulation of extrinsic apoptotic signaling pathway;GO:0007568,biological_process,aging","K11204,ko00480,Glutathione metabolism;K11204,ko00270,Cysteine and methionine metabolism;K11204,ko04212,Longevity regulating pathway - worm"]
["FAM20B",19.54258854,6.456689843,1.596902664,6.312413916,{"v":2.33e-10,"d":"2.33E-10"},{"v":2.47e-09,"d":"2.47E-09"},"ENSG00000116199","A0A024R918,Family with sequence similarity 20, member B, isoform CRA_a","NP_055679.1,glycosaminoglycan xylosylkinase;NP_001311240.1,-;NP_001311239.1,-","PF06702,olgi casein kinase, C-terminal, Fam20","IPR024869,FAM20;IPR009581,FAM20, C-terminal","ENOG410XQEJ,-;KOG3829,Uncharacterized conserved protein","GO:0005794,cellular_component,Golgi apparatus;GO:0005654,cellular_component,nucleoplasm;GO:0005615,cellular_component,extracellular space","-"]
["STK10",18.11734897,5.988344367,1.596531831,6.787309167,{"v":3.07e-11,"d":"3.07E-11"},{"v":3.96e-10,"d":"3.96E-10"},"ENSG00000072786","G3R9P8,Serine/threonine kinase 10","XP_018883536.1,serine/threonine-protein kinase 10","PF12474,Polo kinase kinase;PF00069,Protein kinase domain","IPR022165,Polo kinase kinase;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["USP25",39.6424581,13.10988857,1.596067003,7.695790951,1.79E-12,{"v":3.06e-11,"d":"3.06E-11"},"ENSG00000155313","F6Y2I3,Ubiquitin specific peptidase 25","XP_014988589.1,-","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR003903,Ubiquitin interacting motif;IPR009060,UBA-like superfamily;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","KOG1863,Ubiquitin carboxyl-terminal hydrolase;COG5077,Ubiquitin carboxyl-terminal hydrolase","GO:0071108,biological_process,protein K48-linked deubiquitination;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0070536,biological_process,protein K63-linked deubiquitination;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016579,biological_process,protein deubiquitination;GO:0005829,cellular_component,cytosol;GO:0051117,molecular_function,ATPase binding;GO:1904293,biological_process,negative regulation of ERAD pathway","-"]
["ANO10",1.886386628,0.619753064,1.59575435,2.88888812,0.00408027,0.008566705,"ENSG00000160746","A0A024R2S0,Anoctamin","NP_060545.3,anoctamin-10 isoform 1;NP_001333397.1,-","PF04547,Calcium-activated chloride channel","IPR007632,Anoctamin;IPR031291,Anoctamin-10","KOG2513,Protein required for meiotic chromosome segregation;ENOG410XPYE,-","GO:0016020,cellular_component,membrane;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005622,cellular_component,intracellular","-"]
["CD72",2.945459569,0.967700665,1.59575435,2.88888812,0.00408027,0.008566705,"ENSG00000137101","Q5TLG3,CD72 antigen","NP_001773.1,B-cell differentiation antigen CD72","PF00059,Lectin C-type domain","IPR016187,C-type lectin fold;IPR016186,C-type lectin-like/link domain superfamily;IPR001304,C-type lectin-like","KOG4297,C-type lectin;ENOG410XPJ1,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K06504,ko04662,B cell receptor signaling pathway"]
["SHC1",14.38323773,4.754213966,1.595501066,5.409044042,{"v":1.67e-08,"d":"1.67E-08"},{"v":1.17E-7,"d":"1.17E-07"},"ENSG00000160691","H2R8L2,SHC","XP_009431127.1,-","PF00640,Phosphotyrosine interaction domain (PTB/PID);PF00017,SH2 domain","IPR029586,SHC-transforming protein 1;IPR036860,SH2 domain superfamily;IPR000980,SH2 domain;IPR006019,Phosphotyrosine interaction  domain, Shc-like;IPR035676,SH2 adaptor protein C, SH2 domain;IPR011993,PH-like domain superfamily;IPR006020,PTB/PI domain","KOG3697,Adaptor protein SHC and related proteins;ENOG410XTJN,-","GO:0000187,biological_process,activation of MAPK activity;GO:0098609,biological_process,cell-cell adhesion;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0005158,molecular_function,insulin receptor binding;GO:0005886,cellular_component,plasma membrane;GO:0030971,molecular_function,receptor tyrosine kinase binding;GO:0007507,biological_process,heart development;GO:0035556,biological_process,intracellular signal transduction;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0048408,molecular_function,epidermal growth factor binding;GO:0046875,molecular_function,ephrin receptor binding;GO:0005168,molecular_function,neurotrophin TRKA receptor binding;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0042742,biological_process,defense response to bacterium;GO:0042127,biological_process,regulation of cell proliferation;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:0008286,biological_process,insulin receptor signaling pathway;GO:0000165,biological_process,MAPK cascade;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0001525,biological_process,angiogenesis;GO:0007165,biological_process,signal transduction;GO:0005159,molecular_function,insulin-like growth factor receptor binding;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0071363,biological_process,cellular response to growth factor stimulus;GO:0005622,cellular_component,intracellular;GO:0043410,biological_process,positive regulation of MAPK cascade","-"]
["PLEKHG5",2.299108343,0.757603341,1.595236658,3.51209314,0.000267908,0.000738009,"ENSG00000171680","F7GW00,Pleckstrin homology and RhoGEF domain containing G5","-","PF00621,RhoGEF domain","IPR029071,Ubiquitin-like domain superfamily;IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR001849,Pleckstrin homology domain;IPR035899,Dbl homology (DH) domain superfamily","KOG3521,Predicted guanine nucleotide exchange factor;ENOG410XRPT,-","GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0065009,biological_process,regulation of molecular function","-"]
["KMT5A",18.82464135,6.225533899,1.595187957,5.865667532,{"v":1.82e-09,"d":"1.82E-09"},{"v":1.58e-08,"d":"1.58E-08"},"ENSG00000183955","H2Q758,Histone-lysine N-methyltransferase","XP_016780030.1,N-lysine methyltransferase KMT5A","PF00856,SET domain","IPR001214,SET domain;IPR016858,Class V SAM-dependent methyltransferases","COG2940,Proteins containing SET domain;KOG1085,Predicted methyltransferase (contains a SET domain)","GO:0032259,biological_process,methylation;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0034968,biological_process,histone lysine methylation;GO:0016740,molecular_function,transferase activity;GO:0008168,molecular_function,methyltransferase activity","K11428,ko00310,Lysine degradation"]
["HMBOX1",4.187946488,1.382962988,1.594864275,4.275372109,{"v":5.85e-06,"d":"5.85E-06"},{"v":2.34E-5,"d":"2.34E-05"},"ENSG00000147421","G3SI28,Homeobox containing 1","-","PF00046,Homeobox domain;PF04814,Hepatocyte nuclear factor 1 (HNF-1), N terminus","IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR006899,Hepatocyte nuclear factor 1, N-terminal;IPR010982,Lambda repressor-like, DNA-binding domain superfamily;IPR001387,Cro/C1-type helix-turn-helix domain","-","GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0045893,biological_process,positive regulation of transcription, DNA-templated","-"]
["H6PD",4.254462425,1.406130008,1.594714709,4.770582158,{"v":5.7e-07,"d":"5.70E-07"},{"v":2.84e-06,"d":"2.84E-06"},"ENSG00000049239","R4GMU1,GDH/6PGL endoplasmic bifunctional protein","NP_001269516.1,GDH/6PGL endoplasmic bifunctional protein isoform 1 precursor","PF01182,lucosamine-6-phosphate isomerases/6-phosphogluconolactonase;PF02781,lucose-6-phosphate dehydrogenase, C-terminal domain;PF00479,lucose-6-phosphate dehydrogenase, NAD binding domain","IPR019796,Glucose-6-phosphate dehydrogenase, active site;IPR022675,Glucose-6-phosphate dehydrogenase, C-terminal;IPR037171,NagB/RpiA transferase-like;IPR005900,6-phosphogluconolactonase, DevB-type;IPR022674,Glucose-6-phosphate dehydrogenase, NAD-binding;IPR006148,Glucosamine/galactosamine-6-phosphate isomerase;IPR036291,NAD(P)-binding domain superfamily;IPR001282,Glucose-6-phosphate dehydrogenase","KOG3147,6-phosphogluconolactonase - like protein;COG0363,6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase;KOG0563,Glucose-6-phosphate 1-dehydrogenase;COG0364,Glucose-6-phosphate 1-dehydrogenase","GO:0005975,biological_process,carbohydrate metabolic process;GO:0006006,biological_process,glucose metabolic process;GO:0006739,biological_process,NADP metabolic process;GO:0005737,cellular_component,cytoplasm;GO:0004345,molecular_function,glucose-6-phosphate dehydrogenase activity;GO:0097305,biological_process,response to alcohol;GO:0030246,molecular_function,carbohydrate binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0050661,molecular_function,NADP binding;GO:0005739,cellular_component,mitochondrion;GO:0017057,molecular_function,6-phosphogluconolactonase activity;GO:0055114,biological_process,oxidation-reduction process;GO:0006098,biological_process,pentose-phosphate shunt","-"]
["SETD3",13.3651431,4.421056506,1.594564792,5.55719315,{"v":9.55e-09,"d":"9.55E-09"},{"v":7.07e-08,"d":"7.07E-08"},"ENSG00000183576","A0A024R6K3,Histone-lysine N-methyltransferase","XP_011535534.1,-;XP_016877188.1,-;XP_016877189.1,-;NP_115609.2,histone-lysine N-methyltransferase setd3 isoform a;XP_011535533.2,-","PF00856,SET domain;PF09273,Rubisco LSMT substrate-binding","IPR001214,SET domain;IPR036464,Rubisco LSMT, substrate-binding domain superfamily;IPR015353,Rubisco LSMT, substrate-binding domain;IPR025785,Histone-lysine N-methyltransferase, SETD3","KOG1337,N-methyltransferase;ENOG410Y7DR,-","GO:0018022,biological_process,peptidyl-lysine methylation;GO:0042800,molecular_function,histone methyltransferase activity (H3-K4 specific);GO:0051149,biological_process,positive regulation of muscle cell differentiation;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0018026,biological_process,peptidyl-lysine monomethylation;GO:0003713,molecular_function,transcription coactivator activity;GO:0016740,molecular_function,transferase activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0046975,molecular_function,histone methyltransferase activity (H3-K36 specific);GO:0010452,biological_process,histone H3-K36 methylation;GO:0018027,biological_process,peptidyl-lysine dimethylation;GO:0008168,molecular_function,methyltransferase activity;GO:0000790,cellular_component,nuclear chromatin;GO:0032259,biological_process,methylation;GO:0051568,biological_process,histone H3-K4 methylation;GO:0018023,biological_process,peptidyl-lysine trimethylation;GO:0001102,molecular_function,RNA polymerase II activating transcription factor binding","-"]
["OTUD4",5.776410799,1.911520373,1.593542068,5.164088621,{"v":6.11e-08,"d":"6.11E-08"},{"v":3.76e-07,"d":"3.76E-07"},"ENSG00000164164","A0A0D9S175,OTU deubiquitinase 4","XP_007998085.1,OTU domain-containing protein 4 isoform X1","PF02338,OTU-like cysteine protease","IPR003323,OTU domain","-","GO:0071108,biological_process,protein K48-linked deubiquitination;GO:1903093,biological_process,regulation of protein K48-linked deubiquitination;GO:0061578,molecular_function,Lys63-specific deubiquitinase activity;GO:2000660,biological_process,negative regulation of interleukin-1-mediated signaling pathway;GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0034122,biological_process,negative regulation of toll-like receptor signaling pathway;GO:0070536,biological_process,protein K63-linked deubiquitination;GO:1901537,biological_process,positive regulation of DNA demethylation;GO:0032947,molecular_function,protein-containing complex scaffold activity","-"]
["TRIB3",22.47365964,7.442559323,1.593065993,5.709246669,{"v":4e-09,"d":"4.00E-09"},{"v":3.21e-08,"d":"3.21E-08"},"ENSG00000101255","J3KR25,Tribbles homolog 3","XP_016883478.1,-;NP_001288130.1,tribbles homolog 3 isoform 2","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR024106,Pseudokinase tribbles, TRB3;IPR024104,Pseudokinase tribbles family/serine-threonine-protein kinase 40;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0583,Serine/threonine protein kinase","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0045717,biological_process,negative regulation of fatty acid biosynthetic process;GO:0010827,biological_process,regulation of glucose transmembrane transport;GO:0019901,molecular_function,protein kinase binding;GO:0005730,cellular_component,nucleolus;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0032092,biological_process,positive regulation of protein binding;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0045599,biological_process,negative regulation of fat cell differentiation;GO:1903507,biological_process,negative regulation of nucleic acid-templated transcription;GO:0003714,molecular_function,transcription corepressor activity;GO:0004672,molecular_function,protein kinase activity;GO:0055106,molecular_function,ubiquitin-protein transferase regulator activity;GO:0031965,cellular_component,nuclear membrane;GO:0051443,biological_process,positive regulation of ubiquitin-protein transferase activity;GO:0019899,molecular_function,enzyme binding;GO:0005524,molecular_function,ATP binding;GO:0032869,biological_process,cellular response to insulin stimulus","-"]
["C2orf68",27.11985344,8.984200511,1.593050262,6.333290841,{"v":2.14e-10,"d":"2.14E-10"},{"v":2.28E-9,"d":"2.28E-09"},"ENSG00000168887","L7T9J5,HCRCN81 protein","NP_001013671.2,UPF0561 protein C2orf68","PF10573,Uncharacterised protein family UPF0561","IPR018888,Uncharacterised protein family UPF0561","ENOG4111P0A,-;ENOG410IZ82,-","-","-"]
["CLSTN1",49.25194235,16.32717652,1.59253964,7.517784688,{"v":3.28e-12,"d":"3.28E-12"},{"v":5.26e-11,"d":"5.26E-11"},"ENSG00000171603","H2PXY9,Calsyntenin 1","XP_003307846.2,calsyntenin-1 isoform X4","PF13385,Concanavalin A-like lectin/glucanases superfamily;PF00028,Cadherin domain","IPR002126,Cadherin;IPR015919,Cadherin-like;IPR026914,Calsyntenin;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily","ENOG410XT2J,-;KOG1834,Calsyntenin","GO:0009986,cellular_component,cell surface;GO:0045211,cellular_component,postsynaptic membrane;GO:0019894,molecular_function,kinesin binding;GO:0050806,biological_process,positive regulation of synaptic transmission;GO:0001540,molecular_function,amyloid-beta binding;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0014069,cellular_component,postsynaptic density;GO:0005576,cellular_component,extracellular region;GO:0016020,cellular_component,membrane;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0001558,biological_process,regulation of cell growth;GO:0042988,molecular_function,X11-like protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space","-"]
["CANT1",24.60003315,8.15267563,1.592394175,6.197030815,3.88E-10,{"v":3.93e-09,"d":"3.93E-09"},"ENSG00000171302","A0A024R8U8,Calcium activated nucleotidase 1, isoform CRA_b","XP_005257078.1,-;XP_005257079.1,-;XP_011522595.1,-;XP_006721746.1,-;XP_011522596.1,-;XP_011522593.1,-;XP_011522597.1,-;NP_620148.1,soluble calcium-activated nucleotidase 1;NP_001153244.1,-;NP_001153245.1,-","PF06079,Apyrase","IPR036258,Apyrase superfamily;IPR009283,Apyrase","KOG4494,Cell surface ATP diphosphohydrolase Apyrase;ENOG410XS4T,-","GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0017110,molecular_function,nucleoside-diphosphatase activity;GO:0005509,molecular_function,calcium ion binding","K12304,ko00230,Purine metabolism;K12304,ko00240,Pyrimidine metabolism"]
["BLM",2.573602552,0.850294393,1.59180992,3.591353884,0.000150034,4.37806E-4,"ENSG00000197299","B2RAN0,cDNA, FLJ95010, highly similar to Homo sapiens Bloom syndrome","-","PF08072,BDHCT (NUC031) domain;PF00271,Helicase conserved C-terminal domain;PF00270,AD/DEAH box helicase;PF16124,RecQ zinc-binding;PF00570,HRDC domain;PF09382,RQC domain;PF16202,N-terminal region of Bloom syndrome protein;PF16204,BDHCT-box associated domain on Bloom syndrome protein","IPR036390,Winged helix DNA-binding domain superfamily;IPR004589,DNA helicase, ATP-dependent, RecQ type;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR032439,Bloom syndrome protein, BDHCT-box associated domain;IPR018982,RQC domain;IPR010997,HRDC-like superfamily;IPR002121,HRDC domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR012532,BDHCT;IPR011545,DEAD/DEAH box helicase domain;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR001650,Helicase, C-terminal;IPR032437,Bloom syndrome protein, N-terminal domain;IPR032284,ATP-dependent DNA helicase RecQ, zinc-binding domain","COG0514,Superfamily II DNA helicase;KOG0351,ATP-dependent DNA helicase","GO:0003677,molecular_function,DNA binding;GO:0043140,molecular_function,ATP-dependent 3'-5' DNA helicase activity;GO:0044237,biological_process,cellular metabolic process;GO:0003676,molecular_function,nucleic acid binding;GO:0006260,biological_process,DNA replication;GO:0005622,cellular_component,intracellular;GO:0003824,molecular_function,catalytic activity;GO:0005634,cellular_component,nucleus;GO:0008026,molecular_function,ATP-dependent helicase activity;GO:0016818,molecular_function,hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0032508,biological_process,DNA duplex unwinding;GO:0006281,biological_process,DNA repair;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0006310,biological_process,DNA recombination","-"]
["ASAH1",3.536114792,1.171900733,1.591474781,5.214663754,{"v":5.9e-08,"d":"5.90E-08"},{"v":3.66e-07,"d":"3.66E-07"},"ENSG00000104763","G3RF26,N-acylsphingosine amidohydrolase 1","-","PF15508,beta subunit of N-acylethanolamine-hydrolyzing acid amidase;PF02275,Linear amide C-N hydrolases, choloylglycine hydrolase family","IPR029132,Choloylglycine hydrolase/NAAA C-terminal;IPR029130,Acid ceramidase, N-terminal;IPR016699,Acid ceramidase-like","-","GO:0006629,biological_process,lipid metabolic process;GO:0005764,cellular_component,lysosome;GO:0005615,cellular_component,extracellular space","-"]
["WDR78",1.629350639,0.537633934,1.590427888,3.009934416,2.039309E-3,0.004596443,"ENSG00000152763","A0AVI9,WD repeat domain 78","NP_079039.4,WD repeat-containing protein 78 isoform 1","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","ENOG410IU36,-;ENOG410YJ9J,-","-","-"]
["AMACR",2.25778559,0.744997498,1.590427888,3.009934416,2.039309E-3,0.004596443,"ENSG00000242110","Q53GV0,Alpha-methylacyl-CoA racemase isoform 1 variant","-","PF02515,CoA-transferase family III","IPR023606,CoA-transferase family III domain superfamily;IPR003673,CoA-transferase family III","COG1804,Predicted acyl-CoA transferases/carnitine dehydratase;KOG3957,Predicted L-carnitine dehydratase/alpha-methylacyl-CoA racemase","GO:0003824,molecular_function,catalytic activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MCC",1.016486756,0.335408328,1.590427888,3.009934416,2.039309E-3,0.004596443,"ENSG00000171444","H2R2A3,Uncharacterized protein","-","PF13499,-hand domain pair;PF10506,PDZ domain of MCC-2 bdg protein for Usher syndrome","IPR019536,Usher syndrome type-1C protein-binding protein 1, PDZ domain","ENOG410IESN,-;ENOG410XQHM,-","-","-"]
["MANEA",2.105873662,0.694871389,1.590427888,3.009934416,2.039309E-3,0.004596443,"ENSG00000172469","K7AFP6,Mannosidase, endo-alpha","-","PF16317,lycosyl hydrolase family 99","IPR017853,Glycoside hydrolase superfamily;IPR026071,Glycosyl hydrolase family 99","ENOG410XT8Q,-;ENOG410IG22,-","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds","-"]
["LNX2",5.132054145,1.699572657,1.590153166,4.059743875,{"v":2.92e-05,"d":"2.92E-05"},{"v":9.94e-05,"d":"9.94E-05"},"ENSG00000139517","G3SH54,Ligand of numb-protein X 2","-","PF00595,PDZ domain (Also known as DHR or GLGF);PF13923,Zinc finger, C3HC4 type (RING finger)","-","-","-","-"]
["RITA1",15.83753243,5.250561918,1.590070936,4.658420009,{"v":9.03e-07,"d":"9.03E-07"},{"v":4.3e-06,"d":"4.30E-06"},"ENSG00000139405","A0A024RBL1,Chromosome 12 open reading frame 52, isoform CRA_a","NP_116237.1,RBPJ-interacting and tubulin-associated protein 1 isoform 1;XP_005254029.1,-","PF17066,RBPJ-interacting and tubulin associated protein","IPR031418,RBPJ-interacting and tubulin-associated protein 1","ENOG411251C,-;ENOG410IKKU,-","GO:0051168,biological_process,nuclear export;GO:0007219,biological_process,Notch signaling pathway;GO:0005634,cellular_component,nucleus;GO:0015631,molecular_function,tubulin binding","-"]
["ARHGAP35",25.25587672,8.391913934,1.589196051,7.571160908,{"v":3.1e-12,"d":"3.10E-12"},{"v":5e-11,"d":"5.00E-11"},"ENSG00000160007","K7EV13,Rho GTPase activating protein 35","-","PF00071,Ras family;PF01846,domain;PF00620,RhoGAP domain;PF16512,p190-A and -B Rho GAPs FF domain","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001806,Small GTPase superfamily;IPR002713,FF domain;IPR036517,FF domain superfamily;IPR000198,Rho GTPase-activating protein domain;IPR032835,Rho GTPase-activating protein, FF domain;IPR008936,Rho GTPase activation protein","ENOG410XR4E,-;KOG4271,Rho-GTPase activating protein","GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding;GO:0007165,biological_process,signal transduction","-"]
["ZNF18",5.912852223,1.958148078,1.588754866,3.666442059,1.12166E-4,0.000335642,"ENSG00000154957","B3KXT5,cDNA FLJ46015 fis, clone SPLEN2012571, highly similar to Zinc finger protein 18","NP_001290210.1,-","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF01352,KRAB box;PF02023,SCAN domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR003309,SCAN domain;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR038269,SCAN domain superfamily;IPR027764,Zinc finger protein 18/446","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","-"]
["ETFDH",5.496517941,1.823188544,1.588014196,4.114241445,{"v":1.81e-05,"d":"1.81E-05"},{"v":6.5e-05,"d":"6.50E-05"},"ENSG00000171503","Q547S8,Electron transfer flavoprotein ubiquinone oxidoreductase","-","PF01946,Thi4 family;PF13450,NAD(P)-binding Rossmann-like domain;PF00890,AD binding domain;PF05187,lectron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S","IPR000103,Pyridine nucleotide-disulphide oxidoreductase, class-II;IPR036188,FAD/NAD(P)-binding domain superfamily;IPR017896,4Fe-4S ferredoxin-type, iron-sulphur binding domain","KOG2415,Electron transfer flavoprotein ubiquinone oxidoreductase;COG0644,Dehydrogenases (flavoproteins)","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity","-"]
["AMOTL1",33.74371372,11.23230943,1.586670326,7.824362146,{"v":1.84e-12,"d":"1.84E-12"},{"v":3.14e-11,"d":"3.14E-11"},"ENSG00000166025","A0A024R3A6,Angiomotin like 1, isoform CRA_a","NP_570899.1,angiomotin-like protein 1 isoform 1","PF12240,Angiomotin C terminal","IPR009114,Angiomotin;IPR024646,Angiomotin, C-terminal","ENOG410XSY2,-;ENOG410IJU5,-","GO:0043536,biological_process,positive regulation of blood vessel endothelial cell migration;GO:0035329,biological_process,hippo signaling;GO:0003365,biological_process,establishment of cell polarity involved in ameboidal cell migration;GO:0005923,cellular_component,bicellular tight junction;GO:0030027,cellular_component,lamellipodium;GO:0016324,cellular_component,apical plasma membrane;GO:0031410,cellular_component,cytoplasmic vesicle","K06104,ko04530,Tight junction"]
["ARRDC3",6.593441407,2.191506625,1.586049064,4.496351617,{"v":2.2e-06,"d":"2.20E-06"},{"v":9.69e-06,"d":"9.69E-06"},"ENSG00000113369","G3QNT9,Arrestin domain containing 3","XP_004042314.1,-","PF00339,Arrestin (or S-antigen), N-terminal domain;PF02752,Arrestin (or S-antigen), C-terminal domain","IPR011022,Arrestin C-terminal-like domain;IPR014752,Arrestin, C-terminal;IPR011021,Arrestin-like, N-terminal;IPR014756,Immunoglobulin E-set","-","GO:0031651,biological_process,negative regulation of heat generation;GO:0001659,biological_process,temperature homeostasis;GO:0071879,biological_process,positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0005768,cellular_component,endosome;GO:0060613,biological_process,fat pad development;GO:0031699,molecular_function,beta-3 adrenergic receptor binding;GO:0005886,cellular_component,plasma membrane;GO:0007165,biological_process,signal transduction;GO:0044252,-,-;GO:0090327,biological_process,negative regulation of locomotion involved in locomotory behavior;GO:0051443,biological_process,positive regulation of ubiquitin-protein transferase activity;GO:0043588,biological_process,skin development","-"]
["RAD51L3-RFFL",9.370305433,3.109693035,1.586014129,3.737777148,0.000140823,0.000414006,"ENSG00000267618","K7EN88,HCG2039718, isoform CRA_g","-","PF13920,Zinc finger, C3HC4 type (RING finger);PF08423,Rad51","IPR013632,DNA recombination and repair protein Rad51-like, C-terminal;IPR036361,SAP domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR020588,DNA recombination and repair protein RecA-like, ATP-binding domain","KOG1433,DNA repair protein RAD51/RHP55;KOG4275,Predicted E3 ubiquitin ligase;ENOG41101VR,-","GO:0008094,molecular_function,DNA-dependent ATPase activity;GO:0006281,biological_process,DNA repair;GO:0003677,molecular_function,DNA binding;GO:0005524,molecular_function,ATP binding","-"]
["PGAP2",3.140176478,1.0399263,1.585966356,3.121465767,0.001414816,3.295503E-3,"ENSG00000148985","A0A024RCC6,FGF receptor activating protein 1, isoform CRA_d","XP_011518305.1,-;NP_055304.1,post-GPI attachment to proteins factor 2 isoform 1;XP_011518306.1,-","PF10277,rag1/DRAM/Sfk1 family","IPR019402,Frag1/DRAM/Sfk1","ENOG410XT2T,-;KOG3979,FGF receptor activating protein 1","GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0042770,biological_process,signal transduction in response to DNA damage;GO:1902230,biological_process,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0016020,cellular_component,membrane;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane;GO:0042771,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator","-"]
["CCNJ",1.202184921,0.39496558,1.58578756,2.006969738,0.031052599,0.051855294,"ENSG00000107443","G1RSA6,Cyclin J","-","PF02984,Cyclin, C-terminal domain;PF00134,Cyclin, N-terminal domain","IPR004367,Cyclin, C-terminal domain;IPR013763,Cyclin-like;IPR028859,Cyclin-J;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","ENOG410Y1BM,-;ENOG410IEPY,-","GO:0005634,cellular_component,nucleus","-"]
["METRN",1.350667132,0.443747894,1.58578756,2.006969738,0.031052599,0.051855294,"ENSG00000103260","H2QA83,Meteorin, glial cell differentiation regulator","-","-","-","ENOG4111FCI,-;ENOG410IKV7,-","-","-"]
["LNP1",2.217280147,0.728464751,1.58578756,2.006969738,0.031052599,0.051855294,"ENSG00000206535","C9J587,Leukemia NUP98 fusion partner 1","-","PF15419,Leukemia NUP98 fusion partner 1","IPR029280,Leukemia NUP98 fusion partner 1","-","-","-"]
["RAC1P9",12.72107921,4.179380677,1.58578756,2.006969738,0.031052599,0.051855294,"-","-","-","-","-","-","-","-"]
["KRT23",66.03388602,22.01735761,1.584047344,7.008334652,{"v":1.9e-11,"d":"1.90E-11"},{"v":2.58e-10,"d":"2.58E-10"},"ENSG00000108244","A0A024R1X9,Keratin 23","NP_056330.3,keratin, type I cytoskeletal 23 isoform 1","PF00038,Intermediate filament protein","IPR018039,Intermediate filament protein, conserved site;IPR001664,Intermediate filament protein;IPR002957,Keratin, type I","ENOG410IK9C,-;ENOG4111DWD,-","GO:0005882,cellular_component,intermediate filament;GO:0005198,molecular_function,structural molecule activity","-"]
["PUS7L",1.404088627,0.4668568,1.58354157,3.805718266,{"v":8.23e-05,"d":"8.23E-05"},0.00025344,"ENSG00000129317","K7B4W4,Pseudouridylate synthase 7 homolog-like","-","PF01142,tRNA pseudouridine synthase D (TruD)","IPR001656,Pseudouridine synthase, TruD;IPR020103,Pseudouridine synthase, catalytic domain superfamily;IPR011760,Pseudouridine synthase, TruD, insertion domain","COG0585,Uncharacterized conserved protein;KOG2339,Uncharacterized conserved protein","GO:0003723,molecular_function,RNA binding;GO:0001522,biological_process,pseudouridine synthesis;GO:0009451,biological_process,RNA modification;GO:0009982,molecular_function,pseudouridine synthase activity","-"]
["NUFIP1",5.644098528,1.876652034,1.58354157,3.805718266,{"v":8.23e-05,"d":"8.23E-05"},0.00025344,"ENSG00000083635","H2Q7I5,Nuclear fragile X mental retardation protein interacting protein 1","XP_522669.1,nuclear fragile X mental retardation-interacting protein 1","PF12171,Zinc-finger double-stranded RNA-binding;PF10453,Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)","IPR013087,Zinc finger C2H2-type;IPR019496,Nuclear fragile X mental retardation-interacting protein 1, conserved domain;IPR022755,Zinc finger, double-stranded RNA binding","ENOG410IJ6R,-;ENOG4111GKG,-","GO:0030515,molecular_function,snoRNA binding;GO:0000492,biological_process,box C/D snoRNP assembly;GO:0005634,cellular_component,nucleus;GO:0003676,molecular_function,nucleic acid binding","-"]
["TSPAN13",15.48188897,5.156574001,1.583214662,4.576021199,{"v":1.91e-06,"d":"1.91E-06"},{"v":8.53e-06,"d":"8.53E-06"},"ENSG00000106537","H2QU77,Tetraspanin 13","XP_001150657.2,-","PF00335,Tetraspanin family","IPR018499,Tetraspanin/Peripherin;IPR000301,Tetraspanin","KOG3882,Tetraspanin family integral membrane protein;ENOG4111IRY,-","GO:1903169,biological_process,regulation of calcium ion transmembrane transport;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0005246,molecular_function,calcium channel regulator activity;GO:0016020,cellular_component,membrane;GO:0065009,biological_process,regulation of molecular function;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["RAB35",19.77850539,6.598890863,1.582392255,5.754791972,{"v":4.27e-09,"d":"4.27E-09"},{"v":3.41e-08,"d":"3.41E-08"},"ENSG00000111737","A0A1U7R1E1,ras-related protein Rab-35 isoform X1","XP_005079039.1,-","-","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding","-"]
["ADPRHL1",1.173823494,0.389932697,1.582174882,3.224876443,0.000735123,0.001828207,"ENSG00000153531","A0A0U1RQK4,[Protein ADP-ribosylarginine] hydrolase-like protein 1","-","PF03747,ADP-ribosylglycohydrolase","IPR036705,ADP-ribosylation/Crystallin J1 superfamily;IPR005502,ADP-ribosylation/Crystallin J1","-","-","-"]
["TOR1B",4.40496319,1.463285739,1.582174882,3.224876443,0.000735123,0.001828207,"ENSG00000136816","H2PTM9,Torsin family 1 member B","XP_002820342.1,-","PF06309,Torsin","IPR030550,Torsin-1B;IPR010448,Torsin;IPR017378,Torsin 1/2;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG2170,ATPase of the AAA+ superfamily;ENOG410XR06,-","GO:0071763,biological_process,nuclear membrane organization;GO:0005737,cellular_component,cytoplasm;GO:0005788,cellular_component,endoplasmic reticulum lumen;GO:0005783,cellular_component,endoplasmic reticulum;GO:0051260,biological_process,protein homooligomerization;GO:0051085,biological_process,chaperone cofactor-dependent protein refolding;GO:0016887,molecular_function,ATPase activity;GO:0007029,biological_process,endoplasmic reticulum organization;GO:0005635,cellular_component,nuclear envelope;GO:0005524,molecular_function,ATP binding","-"]
["SIRT2",3.319253316,1.105548256,1.58129966,3.870575221,{"v":6.29e-05,"d":"6.29E-05"},0.000199399,"ENSG00000068903","A0A087WYM3,NAD-dependent protein deacetylase","-","PF02146,Sir2 family","IPR017328,Sirtuin, class I;IPR026591,Sirtuin, catalytic core small domain superfamily;IPR003000,Sirtuin family;IPR026590,Sirtuin family, catalytic core domain;IPR029035,DHS-like NAD/FAD-binding domain superfamily","COG0846,NAD-dependent protein deacetylases, SIR2 family;KOG2682,NAD-dependent histone deacetylases and class I sirtuins (SIR2 family)","GO:0016787,molecular_function,hydrolase activity;GO:0070403,molecular_function,NAD+ binding;GO:0005730,cellular_component,nucleolus;GO:0046872,molecular_function,metal ion binding;GO:0005886,cellular_component,plasma membrane;GO:0017136,molecular_function,NAD-dependent histone deacetylase activity;GO:0016575,biological_process,histone deacetylation;GO:0005829,cellular_component,cytosol;GO:0008270,molecular_function,zinc ion binding","-"]
["ADGRG6",6.950326452,2.320288765,1.581095706,5.329533943,{"v":4.09e-08,"d":"4.09E-08"},{"v":2.63e-07,"d":"2.63E-07"},"ENSG00000112414","G3SC49,Adhesion G protein-coupled receptor G6","XP_004044817.2,G-protein coupled receptor 126 isoform X1","PF00002,7 transmembrane receptor (Secretin family);PF00431,CUB domain;PF01825,PCR proteolysis site, GPS, motif;PF00354,Pentaxin family","IPR035914,Spermadhesin, CUB domain superfamily;IPR000832,GPCR, family 2, secretin-like;IPR017981,GPCR, family 2-like;IPR000203,GPS motif;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000859,CUB domain;IPR017983,GPCR, family 2, secretin-like, conserved site;IPR001759,Pentraxin-related","-","GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0016020,cellular_component,membrane;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["WNK1",16.37599193,5.472458373,1.580900992,7.303448133,{"v":7.99e-12,"d":"7.99E-12"},{"v":1.17e-10,"d":"1.17E-10"},"ENSG00000060237","A0A0D9RGY6,WNK lysine deficient protein kinase 1","-","PF00069,Protein kinase domain;PF12202,Oxidative-stress-responsive kinase 1 C-terminal domain","IPR011009,Protein kinase-like domain superfamily;IPR024678,Serine/threonine-protein kinase OSR1/WNK, CCT domain;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway;GO:0005524,molecular_function,ATP binding;GO:0035556,biological_process,intracellular signal transduction;GO:0003084,biological_process,positive regulation of systemic arterial blood pressure;GO:0090188,biological_process,negative regulation of pancreatic juice secretion;GO:0032147,biological_process,activation of protein kinase activity;GO:0010923,biological_process,negative regulation of phosphatase activity;GO:0019869,molecular_function,chloride channel inhibitor activity;GO:0019902,molecular_function,phosphatase binding;GO:0030295,molecular_function,protein kinase activator activity;GO:0005737,cellular_component,cytoplasm;GO:0006811,biological_process,ion transport;GO:0019901,molecular_function,protein kinase binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0050794,biological_process,regulation of cellular process;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0023016,biological_process,signal transduction by trans-phosphorylation;GO:0004672,molecular_function,protein kinase activity","-"]
["METAP1",23.82099587,7.958791476,1.58060398,6.052638759,{"v":9.97e-10,"d":"9.97E-10"},{"v":9.19e-09,"d":"9.19E-09"},"ENSG00000164024","H2QPX3,Methionine aminopeptidase","XP_517355.2,-","PF00557,Metallopeptidase family M24;PF15801,zf-MYND-like zinc finger, mRNA-binding","IPR036005,Creatinase/aminopeptidase-like;IPR031615,MYND-like zinc finger, mRNA-binding;IPR001714,Peptidase M24, methionine aminopeptidase;IPR000994,Peptidase M24;IPR002467,Peptidase M24A, methionine aminopeptidase, subfamily 1","KOG2738,Putative methionine aminopeptidase;COG0024,Methionine aminopeptidase","GO:0006508,biological_process,proteolysis;GO:0070084,biological_process,protein initiator methionine removal;GO:0008235,molecular_function,metalloexopeptidase activity;GO:0070006,molecular_function,metalloaminopeptidase activity;GO:0004177,molecular_function,aminopeptidase activity;GO:0046872,molecular_function,metal ion binding;GO:0016787,molecular_function,hydrolase activity;GO:0008233,molecular_function,peptidase activity","-"]
["PLA2G12A",10.12884705,3.384434972,1.579616729,5.180064236,{"v":9.11e-08,"d":"9.11E-08"},{"v":5.4e-07,"d":"5.40E-07"},"ENSG00000123739","K7BN83,Phospholipase A2, group XIIA","XP_003310492.2,-","PF06951,roup XII secretory phospholipase A2 precursor (PLA2G12)","IPR033113,Phospholipase A2, histidine active site;IPR036444,Phospholipase A2 domain superfamily;IPR010711,Group XII secretory phospholipase A2 precursor","ENOG410IIHB,-;ENOG4111HAE,-","GO:0006644,biological_process,phospholipid metabolic process;GO:0004623,molecular_function,phospholipase A2 activity;GO:0005794,cellular_component,Golgi apparatus;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005509,molecular_function,calcium ion binding;GO:0050482,biological_process,arachidonic acid secretion;GO:0005622,cellular_component,intracellular;GO:0016042,biological_process,lipid catabolic process;GO:0005576,cellular_component,extracellular region","K01047,ko00591,Linoleic acid metabolism;K01047,ko00564,Glycerophospholipid metabolism;K01047,ko04014,Ras signaling pathway;K01047,ko04975,Fat digestion and absorption;K01047,ko00592,alpha-Linolenic acid metabolism;K01047,ko04270,Vascular smooth muscle contraction;K01047,ko04972,Pancreatic secretion;K01047,ko00565,Ether lipid metabolism;K01047,ko00590,Arachidonic acid metabolism"]
["SDC1",87.71824004,29.34843653,1.579280098,7.723926059,2.84E-12,{"v":4.62e-11,"d":"4.62E-11"},"ENSG00000115884","K7BMB3,Syndecan","XP_016803275.1,syndecan-1 isoform X2","PF01034,Syndecan domain","IPR031190,Syndecan-1;IPR030479,Syndecan, conserved site;IPR001050,Syndecan;IPR003585,Neurexin/syndecan/glycophorin C;IPR027789,Syndecan/Neurexin domain","-","GO:0042060,biological_process,wound healing;GO:0009986,cellular_component,cell surface;GO:1903553,biological_process,positive regulation of extracellular exosome assembly;GO:0055002,biological_process,striated muscle cell development;GO:0009897,cellular_component,external side of plasma membrane;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:0048627,biological_process,myoblast development;GO:1903543,biological_process,positive regulation of exosomal secretion;GO:0008022,molecular_function,protein C-terminus binding;GO:0016020,cellular_component,membrane;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane","-"]
["MAP3K4",8.207875269,2.744322925,1.578959059,5.396769809,{"v":2.23e-08,"d":"2.23E-08"},{"v":1.51e-07,"d":"1.51E-07"},"ENSG00000085511","G3RYN0,Mitogen-activated protein kinase kinase kinase 4","XP_004044969.1,mitogen-activated protein kinase kinase kinase 4 isoform X1","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0010225,biological_process,response to UV-C;GO:0032212,biological_process,positive regulation of telomere maintenance via telomerase;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0060718,biological_process,chorionic trophoblast cell differentiation;GO:0051973,biological_process,positive regulation of telomerase activity;GO:0000186,biological_process,activation of MAPKK activity;GO:0005524,molecular_function,ATP binding;GO:0010468,biological_process,regulation of gene expression;GO:0004672,molecular_function,protein kinase activity;GO:0000165,biological_process,MAPK cascade;GO:1900745,biological_process,positive regulation of p38MAPK cascade;GO:0004709,molecular_function,MAP kinase kinase kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0043507,biological_process,positive regulation of JUN kinase activity;GO:1904355,biological_process,positive regulation of telomere capping;GO:0001890,biological_process,placenta development;GO:0019100,biological_process,male germ-line sex determination","K04428,ko04010,MAPK signaling pathway;K04428,ko04912,GnRH signaling pathway;K04428,ko04013,MAPK signaling pathway - fly"]
["CRTC1",5.489028484,1.834727115,1.578402905,4.723213356,{"v":9.78E-7,"d":"9.78E-07"},{"v":4.62e-06,"d":"4.62E-06"},"ENSG00000105662","H2QFU0,Uncharacterized protein","-","PF12886,Transducer of regulated CREB activity, C terminus;PF12885,Transducer of regulated CREB activity middle domain;PF12884,Transducer of regulated CREB activity, N terminus","IPR024785,Transducer of regulated CREB activity, C-terminal;IPR024784,Transducer of regulated CREB activity, middle domain;IPR024786,CREB-regulated transcription coactivator;IPR024783,Transducer of regulated CREB activity, N-terminal","ENOG410XPDQ,-;ENOG410IGNT,-","GO:0043153,biological_process,entrainment of circadian clock by photoperiod;GO:0032793,biological_process,positive regulation of CREB transcription factor activity;GO:0005737,cellular_component,cytoplasm;GO:0097009,biological_process,energy homeostasis;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0008140,molecular_function,cAMP response element binding protein binding;GO:0051289,biological_process,protein homotetramerization;GO:0007613,biological_process,memory;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:1902631,biological_process,negative regulation of membrane hyperpolarization;GO:0005654,cellular_component,nucleoplasm","-"]
["GALNT3",10.03352727,3.356347709,1.577766683,5.013241599,{"v":1.54E-7,"d":"1.54E-07"},{"v":8.66e-07,"d":"8.66E-07"},"ENSG00000115339","B2R8J0,Polypeptide N-acetylgalactosaminyltransferase","-","PF00535,lycosyl transferase family 2;PF00652,Ricin-type beta-trefoil lectin domain","IPR035992,Ricin B-like lectins;IPR000772,Ricin B, lectin domain;IPR029044,Nucleotide-diphospho-sugar transferases;IPR001173,Glycosyltransferase 2-like","ENOG410XPMK,-;KOG3736,Polypeptide N-acetylgalactosaminyltransferase","GO:0005794,cellular_component,Golgi apparatus;GO:0006486,biological_process,protein glycosylation;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity;GO:0030246,molecular_function,carbohydrate binding;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ANKRD16",1.940668072,0.642687372,1.577664955,2.225082328,0.024635692,0.042100689,"ENSG00000134461","G3RBX6,Ankyrin repeat domain 16","XP_004049073.1,-","PF12796,Ankyrin repeats (3 copies);PF13637,Ankyrin repeats (many copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","-","-","-"]
["ATP6V1B1",2.237656853,0.741040584,1.577664955,2.225082328,0.024635692,0.042100689,"ENSG00000116039","A0A096N0R0,ATPase H+ transporting V1 subunit B1","XP_003908841.1,-","PF02874,ATP synthase alpha/beta family, beta-barrel domain;PF00006,ATP synthase alpha/beta family, nucleotide-binding domain","IPR020003,ATPase, alpha/beta subunit, nucleotide-binding domain, active site;IPR000194,ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004100,ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain;IPR022879,V-type ATP synthase regulatory subunit B/beta;IPR005723,ATPase, V1 complex, subunit B","-","GO:0046034,biological_process,ATP metabolic process;GO:0015991,biological_process,ATP hydrolysis coupled proton transport;GO:0001503,biological_process,ossification;GO:0005902,cellular_component,microvillus;GO:1902600,biological_process,proton transmembrane transport;GO:0016328,cellular_component,lateral plasma membrane;GO:0007605,biological_process,sensory perception of sound;GO:0033180,cellular_component,proton-transporting V-type ATPase, V1 domain;GO:0016323,cellular_component,basolateral plasma membrane;GO:0016471,cellular_component,vacuolar proton-transporting V-type ATPase complex;GO:0045851,biological_process,pH reduction;GO:0016324,cellular_component,apical plasma membrane;GO:0005737,cellular_component,cytoplasm;GO:0007588,biological_process,excretion;GO:0015078,molecular_function,proton transmembrane transporter activity;GO:0016020,cellular_component,membrane;GO:0006885,biological_process,regulation of pH;GO:0005829,cellular_component,cytosol;GO:0042472,biological_process,inner ear morphogenesis;GO:0005524,molecular_function,ATP binding;GO:0055074,biological_process,calcium ion homeostasis","-"]
["AC012512.1",8.268110908,2.738134639,1.577664955,2.225082328,0.024635692,0.042100689,"ENSG00000226539","Q5R6H5,Uncharacterized protein DKFZp468J1719","NP_001127572.1,-","PF00010,Helix-loop-helix DNA-binding domain","IPR032647,Max-like protein X;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","KOG1319,bHLHZip transcription factor BIGMAX;ENOG410ZWIP,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0008134,molecular_function,transcription factor binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K09113,ko04931,Insulin resistance;K09113,ko04932,Non-alcoholic fatty liver disease (NAFLD)"]
["RP5-972B16.2",6.222750138,2.060776384,1.577664955,2.225082328,0.024635692,0.042100689,"ENSG00000250349","B4E171,Tetraspanin","-","PF00335,Tetraspanin family;PF00594,Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain","IPR017857,Coagulation factor-like, Gla domain superfamily;IPR018499,Tetraspanin/Peripherin;IPR008952,Tetraspanin, EC2 domain superfamily;IPR000294,Gamma-carboxyglutamic acid-rich (GLA) domain;IPR018503,Tetraspanin, conserved site;IPR000301,Tetraspanin;IPR035972,Gamma-carboxyglutamic acid-rich (GLA) domain superfamily","KOG3882,Tetraspanin family integral membrane protein;ENOG4111IRY,-","GO:0005509,molecular_function,calcium ion binding;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0005576,cellular_component,extracellular region","-"]
["NPEPPS",8.579418138,2.874240746,1.576701773,6.06388553,{"v":9.42e-10,"d":"9.42E-10"},{"v":8.7e-09,"d":"8.70E-09"},"ENSG00000141279","H2QDA2,Aminopeptidase","-","PF01433,Peptidase family M1 domain;PF11838,RAP1-like C-terminal domain","IPR014782,Peptidase M1, membrane alanine aminopeptidase, N-terminal;IPR001930,Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase;IPR034016,Aminopeptidase N-type;IPR024571,ERAP1-like C-terminal domain","KOG1046,Puromycin-sensitive aminopeptidase and related aminopeptidases;COG0308,Aminopeptidase N","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0043171,biological_process,peptide catabolic process;GO:0005737,cellular_component,cytoplasm;GO:0070006,molecular_function,metalloaminopeptidase activity;GO:0004177,molecular_function,aminopeptidase activity;GO:0042277,molecular_function,peptide binding;GO:0046872,molecular_function,metal ion binding;GO:0008233,molecular_function,peptidase activity;GO:0008237,molecular_function,metallopeptidase activity;GO:0008270,molecular_function,zinc ion binding","-"]
["RABGAP1",25.91793771,8.6904843,1.576028015,7.317618066,{"v":9.22e-12,"d":"9.22E-12"},1.34E-10,"ENSG00000011454","G3QMT1,RAB GTPase activating protein 1","XP_018889483.1,-","PF00640,Phosphotyrosine interaction domain (PTB/PID);PF00566,Rab-GTPase-TBC domain;PF12473,Kinesin protein","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain;IPR033185,Rab GTPase-activating protein 1;IPR011993,PH-like domain superfamily;IPR022164,Kinesin-like;IPR006020,PTB/PI domain","-","GO:0017137,molecular_function,Rab GTPase binding;GO:0007049,biological_process,cell cycle;GO:0043087,biological_process,regulation of GTPase activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0005829,cellular_component,cytosol","-"]
["LYSMD3",5.272158417,1.763606791,1.575674689,4.049168785,{"v":2.92e-05,"d":"2.92E-05"},{"v":9.94e-05,"d":"9.94E-05"},"ENSG00000176018","A8K613,HCG37164, isoform CRA_b","NP_938014.1,lysM and putative peptidoglycan-binding domain-containing protein 3 isoform 1;XP_005248478.1,-","PF01476,LysM domain","IPR018392,LysM domain;IPR036779,LysM domain superfamily","KOG2850,Predicted peptidoglycan-binding protein, contains LysM domain;ENOG4112BYV,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SMAD2",4.054962059,1.360534021,1.574848787,6.635770319,{"v":8.74e-11,"d":"8.74E-11"},{"v":1.01E-9,"d":"1.01E-09"},"ENSG00000175387","H2NWB2,Mothers against decapentaplegic homolog","-","PF03165,MH1 domain;PF03166,MH2 domain","IPR003619,MAD homology 1, Dwarfin-type;IPR001132,SMAD domain, Dwarfin-type;IPR013790,Dwarfin;IPR017855,SMAD-like domain superfamily;IPR008984,SMAD/FHA domain superfamily;IPR036578,SMAD MH1 domain superfamily;IPR013019,MAD homology, MH1","ENOG410XQKU,-;KOG3701,TGFbeta receptor signaling protein SMAD and related proteins","GO:0060021,biological_process,roof of mouth development;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046982,molecular_function,protein heterodimerization activity;GO:0032991,cellular_component,protein-containing complex;GO:0035265,biological_process,organ growth;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0003677,molecular_function,DNA binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0048617,biological_process,embryonic foregut morphogenesis;GO:0017015,biological_process,regulation of transforming growth factor beta receptor signaling pathway;GO:0007352,biological_process,zygotic specification of dorsal/ventral axis;GO:0070412,molecular_function,R-SMAD binding;GO:0009749,biological_process,response to glucose;GO:0005634,cellular_component,nucleus;GO:0007182,biological_process,common-partner SMAD protein phosphorylation;GO:0071144,cellular_component,heteromeric SMAD protein complex;GO:1900224,biological_process,positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry;GO:0006468,biological_process,protein phosphorylation;GO:0007507,biological_process,heart development;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0030618,molecular_function,transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity;GO:0001657,biological_process,ureteric bud development;GO:0019902,molecular_function,phosphatase binding;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0010629,biological_process,negative regulation of gene expression;GO:0046332,molecular_function,SMAD binding;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0070723,biological_process,response to cholesterol;GO:0000790,cellular_component,nuclear chromatin;GO:0031016,biological_process,pancreas development;GO:0003682,molecular_function,chromatin binding;GO:0033613,molecular_function,activating transcription factor binding;GO:0032924,biological_process,activin receptor signaling pathway;GO:0070878,molecular_function,primary miRNA binding;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0010628,biological_process,positive regulation of gene expression;GO:0060395,biological_process,SMAD protein signal transduction;GO:0045165,biological_process,cell fate commitment;GO:0001706,biological_process,endoderm formation;GO:0005622,cellular_component,intracellular;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0030073,biological_process,insulin secretion;GO:0001707,biological_process,mesoderm formation;GO:0097718,molecular_function,disordered domain specific binding;GO:0009880,biological_process,embryonic pattern specification;GO:0007369,biological_process,gastrulation;GO:0048340,biological_process,paraxial mesoderm morphogenesis;GO:0051098,biological_process,regulation of binding;GO:0007492,biological_process,endoderm development;GO:0009791,biological_process,post-embryonic development;GO:0032444,cellular_component,activin responsive factor complex;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0030324,biological_process,lung development;GO:0005667,cellular_component,transcription factor complex;GO:0060039,biological_process,pericardium development;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0038092,biological_process,nodal signaling pathway;GO:0003690,molecular_function,double-stranded DNA binding;GO:0048701,biological_process,embryonic cranial skeleton morphogenesis;GO:0030513,biological_process,positive regulation of BMP signaling pathway;GO:0001701,biological_process,in utero embryonic development;GO:0005160,molecular_function,transforming growth factor beta receptor binding;GO:0070410,molecular_function,co-SMAD binding;GO:0034713,molecular_function,type I transforming growth factor beta receptor binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0048589,biological_process,developmental growth;GO:0007389,biological_process,pattern specification process;GO:0071141,cellular_component,SMAD protein complex;GO:0007183,biological_process,SMAD protein complex assembly;GO:0070411,molecular_function,I-SMAD binding","-"]
["MLLT1",14.42795819,4.838911636,1.574675176,5.542426545,{"v":1.43e-08,"d":"1.43E-08"},{"v":1.02E-7,"d":"1.02E-07"},"ENSG00000130382","K7C716,Myeloid/lymphoid or mixed-lineage leukemia translocated to, 1","XP_016790293.1,protein ENL isoform X3","PF03366,YEATS family","IPR038704,YEATS superfamily;IPR005033,YEATS","KOG3149,Transcription initiation factor IIF, auxiliary subunit;COG5033,Transcription initiation factor IIF, auxiliary subunit","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0001650,cellular_component,fibrillar center;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008023,cellular_component,transcription elongation factor complex;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["SP140L",10.54911442,3.537605336,1.574627471,5.348050991,{"v":3.67e-08,"d":"3.67E-08"},{"v":2.39e-07,"d":"2.39E-07"},"ENSG00000185404","H2QJK4,Uncharacterized protein","XP_003309552.1,nuclear body protein SP140-like protein isoform X1","PF03172,HSR domain;PF00439,Bromodomain;PF01342,SAND domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR036427,Bromodomain-like superfamily;IPR010919,SAND-like domain superfamily;IPR030411,Nuclear body protein SP140;IPR004865,HSR domain;IPR001487,Bromodomain;IPR019787,Zinc finger, PHD-finger;IPR000770,SAND domain;IPR019786,Zinc finger, PHD-type, conserved site","ENOG41112UW,-;KOG2177,Predicted E3 ubiquitin ligase","GO:0016604,cellular_component,nuclear body;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding","-"]
["PDE9A",6.313030828,2.115563451,1.574333252,4.529199316,{"v":2.81e-06,"d":"2.81E-06"},{"v":1.21e-05,"d":"1.21E-05"},"ENSG00000160191","A0A0S2Z4T6,Phosphodiesterase","NP_002597.1,high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a","PF00233,3'5'-cyclic nucleotide phosphodiesterase","IPR003607,HD/PDEase domain;IPR023088,3'5'-cyclic nucleotide phosphodiesterase;IPR023174,3'5'-cyclic nucleotide phosphodiesterase, conserved site;IPR002073,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain;IPR036971,3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily","-","GO:0016787,molecular_function,hydrolase activity;GO:0004114,molecular_function,3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0046069,biological_process,cGMP catabolic process;GO:0019934,biological_process,cGMP-mediated signaling;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0010613,biological_process,positive regulation of cardiac muscle hypertrophy;GO:0047555,molecular_function,3',5'-cyclic-GMP phosphodiesterase activity;GO:0043204,cellular_component,perikaryon;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular;GO:0007165,biological_process,signal transduction","K13761,ko00230,Purine metabolism"]
["RRN3",10.34174357,3.469006637,1.573599579,4.88824279,{"v":4.58E-7,"d":"4.58E-07"},{"v":2.32e-06,"d":"2.32E-06"},"ENSG00000085721","H2QAM4,RRN3 RNA polymerase I transcription factor homolog","XP_001143837.3,RNA polymerase I-specific transcription initiation factor RRN3 isoform X1","PF05327,RNA polymerase I specific transcription initiation factor RRN3","IPR007991,RNA polymerase I specific transcription initiation factor RRN3","ENOG410XRJJ,-;KOG2434,RNA polymerase I transcription factor","GO:0001181,molecular_function,transcription factor activity, core RNA polymerase I binding;GO:0042254,biological_process,ribosome biogenesis;GO:0007028,biological_process,cytoplasm organization;GO:0001042,molecular_function,RNA polymerase I core binding;GO:1902254,biological_process,negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0008283,biological_process,cell proliferation;GO:0005730,cellular_component,nucleolus;GO:0048872,biological_process,homeostasis of number of cells;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0001164,molecular_function,RNA polymerase I CORE element sequence-specific DNA binding;GO:0001188,biological_process,RNA polymerase I transcriptional preinitiation complex assembly;GO:0001701,biological_process,in utero embryonic development;GO:0006352,biological_process,DNA-templated transcription, initiation;GO:0070063,molecular_function,RNA polymerase binding;GO:0007000,biological_process,nucleolus organization;GO:0006361,biological_process,transcription initiation from RNA polymerase I promoter;GO:0006356,biological_process,regulation of transcription by RNA polymerase I;GO:2000142,biological_process,regulation of DNA-templated transcription, initiation;GO:0005634,cellular_component,nucleus","-"]
["FLOT1",140.7916555,47.30859533,1.573168877,8.231857995,{"v":1.1E-12,"d":"1.10E-12"},1.99E-11,"ENSG00000137312","G1R0A3,Flotillin 1","XP_003272093.1,-","PF15975,lotillin;PF01145,SPFH domain / Band 7 family","IPR031905,Flotillin, C-terminal domain;IPR027705,Flotillin family;IPR001107,Band 7 domain;IPR036013,Band 7/SPFH domain superfamily","COG2268,Uncharacterized protein conserved in bacteria;KOG2668,Flotillins","GO:0007409,biological_process,axonogenesis;GO:0034451,cellular_component,centriolar satellite;GO:0032226,biological_process,positive regulation of synaptic transmission, dopaminergic;GO:2000049,biological_process,positive regulation of cell-cell adhesion mediated by cadherin;GO:0016020,cellular_component,membrane;GO:0044291,cellular_component,cell-cell contact zone;GO:0051260,biological_process,protein homooligomerization;GO:0044854,biological_process,plasma membrane raft assembly;GO:0005815,cellular_component,microtubule organizing center;GO:0005886,cellular_component,plasma membrane;GO:0071360,biological_process,cellular response to exogenous dsRNA;GO:0046982,molecular_function,protein heterodimerization activity;GO:0050821,biological_process,protein stabilization;GO:0034141,biological_process,positive regulation of toll-like receptor 3 signaling pathway;GO:0005913,cellular_component,cell-cell adherens junction;GO:0002020,molecular_function,protease binding;GO:0016323,cellular_component,basolateral plasma membrane;GO:0016600,cellular_component,flotillin complex;GO:0030027,cellular_component,lamellipodium;GO:0045807,biological_process,positive regulation of endocytosis;GO:0033227,biological_process,dsRNA transport;GO:0001931,cellular_component,uropod;GO:0034116,biological_process,positive regulation of heterotypic cell-cell adhesion;GO:0060355,biological_process,positive regulation of cell adhesion molecule production;GO:0008180,cellular_component,COP9 signalosome;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0032728,biological_process,positive regulation of interferon-beta production;GO:0005768,cellular_component,endosome;GO:0030864,cellular_component,cortical actin cytoskeleton;GO:1903044,biological_process,protein localization to membrane raft;GO:0001819,biological_process,positive regulation of cytokine production;GO:0002090,biological_process,regulation of receptor internalization;GO:0048643,biological_process,positive regulation of skeletal muscle tissue development;GO:1901890,biological_process,positive regulation of cell junction assembly;GO:0032092,biological_process,positive regulation of protein binding;GO:0022617,biological_process,extracellular matrix disassembly;GO:0045121,cellular_component,membrane raft;GO:0005911,cellular_component,cell-cell junction;GO:0005901,cellular_component,caveola;GO:0001765,biological_process,membrane raft assembly;GO:0072659,biological_process,protein localization to plasma membrane;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0070528,biological_process,protein kinase C signaling;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0042383,cellular_component,sarcolemma;GO:1901741,biological_process,positive regulation of myoblast fusion;GO:0044853,cellular_component,plasma membrane raft;GO:0005769,cellular_component,early endosome;GO:0001934,biological_process,positive regulation of protein phosphorylation","K07192,ko04910,Insulin signaling pathway"]
["STK38",36.25649869,12.18658786,1.572189286,6.452583007,2.03E-10,{"v":2.17e-09,"d":"2.17E-09"},"ENSG00000112079","I3MIC6,Serine/threonine kinase 38","XP_005318814.1,-;XP_005318815.1,-","PF00433,Protein kinase C terminal domain;PF00069,Protein kinase domain","IPR017892,Protein kinase, C-terminal;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XQC0,-;KOG0605,NDR and related serine/threonine kinases","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0000166,molecular_function,nucleotide binding;GO:0016740,molecular_function,transferase activity;GO:0000287,molecular_function,magnesium ion binding;GO:0043407,biological_process,negative regulation of MAP kinase activity;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0031435,molecular_function,mitogen-activated protein kinase kinase kinase binding;GO:0005634,cellular_component,nucleus;GO:0006464,biological_process,cellular protein modification process","-"]
["ATP23",5.015545676,1.67053468,1.571800418,2.413960738,0.015604312,0.028362345,"ENSG00000166896","G3R572,Mitochondrial inner membrane protease ATP23","XP_004053530.2,mitochondrial inner membrane protease ATP23 homolog isoform X1","PF09768,Peptidase M76 family","IPR019165,Peptidase M76, ATP23","-","GO:0006508,biological_process,proteolysis;GO:0030054,cellular_component,cell junction;GO:0016787,molecular_function,hydrolase activity;GO:0008237,molecular_function,metallopeptidase activity;GO:0046872,molecular_function,metal ion binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005886,cellular_component,plasma membrane;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0005829,cellular_component,cytosol;GO:0008233,molecular_function,peptidase activity","-"]
["VCL",18.03765515,6.066627036,1.571501808,6.923627007,{"v":3.45e-11,"d":"3.45E-11"},{"v":4.39e-10,"d":"4.39E-10"},"ENSG00000035403","G3R689,Vinculin","XP_004049661.1,-","PF01044,Vinculin family","IPR017997,Vinculin;IPR006077,Vinculin/alpha-catenin;IPR036723,Alpha-catenin/vinculin-like superfamily;IPR000633,Vinculin, conserved site","-","GO:0002102,cellular_component,podosome;GO:0032991,cellular_component,protein-containing complex;GO:0002162,molecular_function,dystroglycan binding;GO:0005886,cellular_component,plasma membrane;GO:0005198,molecular_function,structural molecule activity;GO:0005925,cellular_component,focal adhesion;GO:0005916,cellular_component,fascia adherens;GO:0007155,biological_process,cell adhesion;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0005913,cellular_component,cell-cell adherens junction;GO:0005912,cellular_component,adherens junction;GO:0090136,biological_process,epithelial cell-cell adhesion;GO:0043297,biological_process,apical junction assembly;GO:0043034,cellular_component,costamere;GO:0051015,molecular_function,actin filament binding;GO:0030334,biological_process,regulation of cell migration;GO:0015629,cellular_component,actin cytoskeleton;GO:0045296,molecular_function,cadherin binding;GO:0030032,biological_process,lamellipodium assembly;GO:0003779,molecular_function,actin binding;GO:0034333,biological_process,adherens junction assembly;GO:0002009,biological_process,morphogenesis of an epithelium;GO:0045294,molecular_function,alpha-catenin binding;GO:0005911,cellular_component,cell-cell junction;GO:0005737,cellular_component,cytoplasm;GO:0034394,biological_process,protein localization to cell surface;GO:0048675,biological_process,axon extension;GO:0042383,cellular_component,sarcolemma","-"]
["SCRN3",6.360539606,2.134872832,1.57127963,4.207930275,{"v":1.15E-5,"d":"1.15E-05"},{"v":4.31e-05,"d":"4.31E-05"},"ENSG00000144306","H2QJ02,Secernin 3","XP_001149171.2,secernin-3 isoform X4","PF03577,Peptidase family C69","IPR005322,Peptidase C69, dipeptidase A","COG4690,Dipeptidase;ENOG410IGQK,-","GO:0006508,biological_process,proteolysis;GO:0016805,molecular_function,dipeptidase activity;GO:0006887,biological_process,exocytosis","-"]
["CTC-338M12.7",46.56903909,15.63058837,1.57127963,4.207930275,{"v":1.15E-5,"d":"1.15E-05"},{"v":4.31e-05,"d":"4.31E-05"},"ENSG00000247049","A0A1D5Q0T3,Tripartite motif containing 41","-","-","IPR001841,Zinc finger, RING-type;IPR000315,B-box-type zinc finger;IPR017907,Zinc finger, RING-type, conserved site;IPR020457,Zinc finger, B-box, chordata;IPR013083,Zinc finger, RING/FYVE/PHD-type","-","GO:0046872,molecular_function,metal ion binding;GO:0008270,molecular_function,zinc ion binding;GO:0005622,cellular_component,intracellular","-"]
["KIAA1715",1.926337508,0.646562378,1.569427147,3.652440084,1.47133E-4,0.000430433,"ENSG00000144320","A0A1D5R5A2,Lunapark, ER junction formation factor","-","-","IPR019273,Lunapark domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-290L1.3",251.2319991,84.6511888,1.568734734,6.59287204,{"v":1.48e-10,"d":"1.48E-10"},{"v":1.62E-9,"d":"1.62E-09"},"ENSG00000257453","G3QNV7,Pleckstrin homology like domain family A member 1","-","-","-","-","-","-"]
["NFATC2IP",6.952475498,2.341268952,1.567788653,4.78521685,{"v":7.07e-07,"d":"7.07E-07"},{"v":3.45E-6,"d":"3.45E-06"},"ENSG00000176953","H2NQI0,Nuclear factor of activated T-cells 2 interacting protein","XP_002826318.1,NFATC2-interacting protein","PF11976,Ubiquitin-2 like Rad60 SUMO-like","IPR000626,Ubiquitin domain;IPR029071,Ubiquitin-like domain superfamily;IPR022617,Rad60/SUMO-like domain","KOG1769,Ubiquitin-like proteins;COG5227,Ubiquitin-like protein (sentrin)","GO:0001816,biological_process,cytokine production;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II","-"]
["ZNF468",3.507269709,1.178868672,1.567669474,3.72447151,0.000140823,0.000414006,"ENSG00000204604","A8K8T4,cDNA FLJ76364, highly similar to Homo sapiens zinc finger protein ZNF468","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;ENOG4110PUY,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["RP4-665N4.8",11.89102397,3.977704948,1.567367219,2.580543532,0.007180229,0.014178089,"-","-","-","-","-","-","-","-"]
["TTC39A",0.83702038,0.279994399,1.567367219,2.580543532,0.007180229,0.014178089,"ENSG00000085831","G3RB17,Tetratricopeptide repeat domain 39A","XP_018873833.1,tetratricopeptide repeat protein 39A isoform X1","PF10300,Protein of unknown function (DUF3808)","IPR030416,Tetratricopeptide repeat protein 39A;IPR019412,Inclusion body clearance protein Iml2/Tetratricopeptide repeat protein 39","-","-","-"]
["ZNF628",2.034844143,0.680682306,1.567367219,2.580543532,0.007180229,0.014178089,"ENSG00000197483","A0A087WSX5,Zinc finger protein 628","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["ATG4B",1.180503886,0.394894179,1.567367219,2.580543532,0.007180229,0.014178089,"ENSG00000168397","B4DZK0,Cysteine protease","-","PF03416,Peptidase family C54","IPR032916,Cysteine protease ATG4B, metazoa;IPR005078,Peptidase C54","KOG2674,Cysteine protease required for autophagy - Apg4p/Aut2p;ENOG410XPQ0,-","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0006914,biological_process,autophagy;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0004197,molecular_function,cysteine-type endopeptidase activity;GO:0008233,molecular_function,peptidase activity","-"]
["SUGP2",4.823233938,1.625161159,1.567029431,4.818332581,{"v":6.04e-07,"d":"6.04E-07"},{"v":2.99e-06,"d":"2.99E-06"},"ENSG00000064607","M0R2Z9,SURP and G-patch domain-containing protein 2","NP_001308627.1,SURP and G-patch domain-containing protein 2 isoform 2;NP_001308628.1,-","PF01805,Surp module;PF01585,-patch domain","IPR000467,G-patch domain;IPR000061,SWAP/Surp;IPR035967,SWAP/Surp superfamily","ENOG4111IFE,-;KOG0965,Predicted RNA-binding protein, contains SWAP and G-patch domains","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0016604,cellular_component,nuclear body;GO:0006396,biological_process,RNA processing;GO:0005654,cellular_component,nucleoplasm","-"]
["UBALD2",116.6818633,39.3852555,1.566388142,7.141631714,{"v":2.04e-11,"d":"2.04E-11"},{"v":2.75e-10,"d":"2.75E-10"},"ENSG00000185262","H2QDX7,Family with sequence similarity 100, member B","XP_001151089.1,-","PF14555,UBA-like domain","IPR009060,UBA-like superfamily","ENOG4111XJX,-;ENOG410J092,-","-","-"]
["TSPAN2",9.122369218,3.074847578,1.565760887,4.438769847,{"v":4.07E-6,"d":"4.07E-06"},{"v":1.69e-05,"d":"1.69E-05"},"ENSG00000134198","G1QYJ8,Tetraspanin","XP_003268074.1,-","PF00335,Tetraspanin family","IPR018503,Tetraspanin, conserved site;IPR018499,Tetraspanin/Peripherin;IPR008952,Tetraspanin, EC2 domain superfamily;IPR000301,Tetraspanin","KOG3882,Tetraspanin family integral membrane protein;ENOG4111IRY,-","GO:0014005,biological_process,microglia development;GO:0043209,cellular_component,myelin sheath;GO:0014002,biological_process,astrocyte development;GO:0042552,biological_process,myelination;GO:0005886,cellular_component,plasma membrane;GO:0006954,biological_process,inflammatory response;GO:0016020,cellular_component,membrane;GO:0061564,biological_process,axon development;GO:0016021,cellular_component,integral component of membrane;GO:0048709,biological_process,oligodendrocyte differentiation","-"]
["PACS2",4.475306467,1.51070261,1.565007673,5.245361698,{"v":7.46e-08,"d":"7.46E-08"},{"v":4.5e-07,"d":"4.50E-07"},"ENSG00000179364","H2Q909,Uncharacterized protein","-","PF10254,PACS-1 cytosolic sorting protein","IPR019381,Phosphofurin acidic cluster sorting protein 1","ENOG410XQNV,-;KOG3709,PACS-1 cytosolic sorting protein","GO:0044325,molecular_function,ion channel binding","-"]
["SNIP1",16.46869666,5.563843278,1.564364668,5.775996139,{"v":5.28E-9,"d":"5.28E-09"},{"v":4.12e-08,"d":"4.12E-08"},"ENSG00000163877","B1AK66,Smad nuclear interacting protein 1","NP_078976.2,smad nuclear-interacting protein 1","PF00498,HA domain","IPR008984,SMAD/FHA domain superfamily;IPR000253,Forkhead-associated (FHA) domain","ENOG4111F4H,-;KOG1882,Transcriptional regulator SNIP1, contains FHA domain","GO:0007249,biological_process,I-kappaB kinase/NF-kappaB signaling;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005654,cellular_component,nucleoplasm","-"]
["PAPD5",4.052917509,1.367946603,1.564002043,4.521618863,{"v":3.45E-6,"d":"3.45E-06"},{"v":1.45E-5,"d":"1.45E-05"},"ENSG00000121274","G1QJ43,Poly","-","PF03828,Cid1 family poly A polymerase;PF01909,Nucleotidyltransferase domain","IPR002934,Polymerase, nucleotidyl transferase domain;IPR002058,PAP/25A-associated","COG5260,DNA polymerase sigma;KOG1906,DNA polymerase sigma","GO:0032211,biological_process,negative regulation of telomere maintenance via telomerase;GO:0071044,biological_process,histone mRNA catabolic process;GO:0043630,biological_process,ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process;GO:0016779,molecular_function,nucleotidyltransferase activity","K03514,ko03018,RNA degradation"]
["AC009133.21",15.66136431,5.256632809,1.563898321,2.729559808,0.004744033,0.009780389,"ENSG00000275857","Q14984,OriP binding protein","-","PF12836,Helix-hairpin-helix motif","IPR003583,Helix-hairpin-helix DNA-binding motif, class 1;IPR026986,Kinesin-like protein KIF22  (Kid);IPR010994,RuvA domain 2-like;IPR027640,Kinesin-like protein","COG5059,Kinesin-like protein;KOG0242,Kinesin-like protein","GO:0006281,biological_process,DNA repair;GO:0007018,biological_process,microtubule-based movement;GO:0003677,molecular_function,DNA binding;GO:0003777,molecular_function,microtubule motor activity","-"]
["RFX1",1.607689913,0.539610431,1.563898321,2.729559808,0.004744033,0.009780389,"ENSG00000132005","H2QFJ5,Uncharacterized protein","XP_524133.2,MHC class II regulatory factor RFX1 isoform X5","PF04589,RFX1 transcription activation region;PF02257,RFX DNA-binding domain","IPR007668,RFX1 transcription activation region;IPR003150,DNA-binding RFX-type winged-helix domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR036390,Winged helix DNA-binding domain superfamily","ENOG410XSHE,-;KOG3712,RFX family transcription factor","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006955,biological_process,immune response;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["FBXW11",12.51807113,4.230189716,1.563825775,5.574233233,{"v":1.36e-08,"d":"1.36E-08"},{"v":9.76E-8,"d":"9.76E-08"},"ENSG00000072803","H9FRX5,F-box and WD repeat domain containing 11","XP_014996884.1,-","PF12937,-box-like;PF00400,WD domain, G-beta repeat;PF12125,domain of beta-TrCP","IPR021977,D domain of beta-TrCP;IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat;IPR036047,F-box-like domain superfamily;IPR001810,F-box domain","KOG0281,Beta-TrCP (transducin repeats containing)/Slimb proteins;ENOG410XTA8,-","GO:0046983,molecular_function,protein dimerization activity","-"]
["PNPLA6",3.0292577,1.021771197,1.563341512,3.921038869,{"v":4.84e-05,"d":"4.84E-05"},0.000157724,"ENSG00000032444","G3QXS8,Patatin like phospholipase domain containing 6","-","PF00027,Cyclic nucleotide-binding domain;PF01734,Patatin-like phospholipase","IPR014710,RmlC-like jelly roll fold;IPR001423,Lysophospholipase patatin, conserved site;IPR000595,Cyclic nucleotide-binding domain;IPR016035,Acyl transferase/acyl hydrolase/lysophospholipase;IPR018490,Cyclic nucleotide-binding-like;IPR002641,Patatin-like phospholipase domain","-","GO:0006629,biological_process,lipid metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0004622,molecular_function,lysophospholipase activity;GO:0046470,biological_process,phosphatidylcholine metabolic process;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0016042,biological_process,lipid catabolic process;GO:0016021,cellular_component,integral component of membrane","-"]
["ATP5B",162.9087043,55.17502456,1.561720139,7.989706023,{"v":2.55e-12,"d":"2.55E-12"},{"v":4.17e-11,"d":"4.17E-11"},"ENSG00000110955","V9HW31,ATP synthase subunit beta","NP_001677.2,ATP synthase subunit beta, mitochondrial precursor","PF02874,ATP synthase alpha/beta family, beta-barrel domain;PF00006,ATP synthase alpha/beta family, nucleotide-binding domain","IPR020003,ATPase, alpha/beta subunit, nucleotide-binding domain, active site;IPR000194,ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004100,ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain;IPR005722,ATP synthase, F1 complex, beta subunit;IPR024034,ATPase, F1/V1 complex, beta/alpha subunit, C-terminal;IPR036121,ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily;IPR003593,AAA+ ATPase domain","KOG1350,F0F1-type ATP synthase, beta subunit;COG0055,F0F1-type ATP synthase, beta subunit","GO:0046034,biological_process,ATP metabolic process;GO:0043209,cellular_component,myelin sheath;GO:0006629,biological_process,lipid metabolic process;GO:0005515,molecular_function,protein binding;GO:0000166,molecular_function,nucleotide binding;GO:0045261,cellular_component,proton-transporting ATP synthase complex, catalytic core F(1);GO:0006754,biological_process,ATP biosynthetic process;GO:0015986,biological_process,ATP synthesis coupled proton transport;GO:0046933,molecular_function,proton-transporting ATP synthase activity, rotational mechanism;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0006933,biological_process,negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0099132,biological_process,ATP hydrolysis coupled cation transmembrane transport;GO:0005524,molecular_function,ATP binding","K02133,ko05012,Parkinson's disease;K02133,ko05010,Alzheimer's disease;K02133,ko00190,Oxidative phosphorylation;K02133,ko05016,Huntington's disease"]
["SF3A1",50.27596693,17.03290779,1.561239657,7.741342067,4.56E-12,{"v":7.05e-11,"d":"7.05E-11"},"ENSG00000099995","K7CBX7,Splicing factor 3a, subunit 1, 120kDa","-","PF12230,Pre-mRNA splicing factor PRP21 like protein;PF00240,Ubiquitin family;PF01805,Surp module","-","-","-","-"]
["SNRNP200",24.34151224,8.247066392,1.561101583,7.483907821,{"v":8.17e-12,"d":"8.17E-12"},1.19E-10,"ENSG00000144028","H2QIC8,Small nuclear ribonucleoprotein 200kDa","XP_001147672.1,-","PF00271,Helicase conserved C-terminal domain;PF00270,AD/DEAH box helicase;PF02889,Sec63 Brl domain","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004179,Sec63 domain;IPR014756,Immunoglobulin E-set;IPR035892,C2 domain superfamily;IPR011545,DEAD/DEAH box helicase domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR001650,Helicase, C-terminal","COG1204,Superfamily II helicase;KOG0952,DNA/RNA helicase MER3/SLH1, DEAD-box superfamily","GO:0004004,molecular_function,ATP-dependent RNA helicase activity;GO:0003676,molecular_function,nucleic acid binding;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0005634,cellular_component,nucleus;GO:0005681,cellular_component,spliceosomal complex;GO:0008026,molecular_function,ATP-dependent helicase activity;GO:0071013,cellular_component,catalytic step 2 spliceosome;GO:0005682,cellular_component,U5 snRNP;GO:0046540,cellular_component,U4/U6 x U5 tri-snRNP complex;GO:0042802,molecular_function,identical protein binding;GO:0005524,molecular_function,ATP binding;GO:0030529,,;GO:0005654,cellular_component,nucleoplasm","K12854,ko03040,Spliceosome"]
["HECTD1",14.01273932,4.749123756,1.560455481,6.892009879,{"v":5.51e-11,"d":"5.51E-11"},{"v":6.65e-10,"d":"6.65E-10"},"ENSG00000092148","A0A087X2H1,E3 ubiquitin-protein ligase HECTD1","-","PF00632,HECT-domain (ubiquitin-transferase);PF13857,Ankyrin repeats (many copies);PF06701,Mib_herc2;PF07738,Sad1 / UNC-like C-terminal","IPR002110,Ankyrin repeat;IPR020683,Ankyrin repeat-containing domain;IPR000569,HECT domain;IPR010606,Mib-herc2;IPR008979,Galactose-binding-like domain superfamily;IPR012919,SUN domain;IPR036770,Ankyrin repeat-containing domain superfamily;IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR037252,Mib/herc2 domain superfamily;IPR035983,HECT, E3 ligase catalytic domain","KOG4276,Predicted hormone receptor interactor;COG5021,Ubiquitin-protein ligase","GO:0046872,molecular_function,metal ion binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016740,molecular_function,transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["ATP13A2",4.610876607,1.559411027,1.560039192,4.093820303,{"v":2.9E-5,"d":"2.90E-05"},{"v":9.92e-05,"d":"9.92E-05"},"ENSG00000159363","K7DQ11,Cation-transporting ATPase","-","PF12409,P5-type ATPase cation transporter;PF00122,1-E2 ATPase;PF00702,haloacid dehalogenase-like hydrolase","-","-","-","-"]
["SORL1",1.245356307,0.421182895,1.560039192,4.093820303,{"v":2.9E-5,"d":"2.90E-05"},{"v":9.92e-05,"d":"9.92E-05"},"ENSG00000137642","A0A024R3H2,Sortilin-related receptor, L","NP_003096.1,sortilin-related receptor preproprotein","PF00057,Low-density lipoprotein receptor domain class A;PF00041,ibronectin type III domain;PF15902,Sortilin, neurotensin receptor 3,;PF15901,Sortilin, neurotensin receptor 3, C-terminal;PF00058,Low-density lipoprotein receptor repeat class B","IPR003961,Fibronectin type III;IPR000033,LDLR class B repeat;IPR006581,VPS10;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR031777,Sortilin, C-terminal;IPR036116,Fibronectin type III superfamily;IPR031778,Sortilin, N-terminal;IPR011042,Six-bladed beta-propeller, TolB-like;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR013783,Immunoglobulin-like fold;IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR036055,LDL receptor-like superfamily","KOG3511,Sortilin and related receptors;ENOG410Y3W5,-;KOG1215,Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains","GO:0005794,cellular_component,Golgi apparatus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TJAP1",12.47009219,4.228856212,1.55898241,5.838773116,{"v":4.6e-09,"d":"4.60E-09"},{"v":3.65e-08,"d":"3.65E-08"},"ENSG00000137221","G3RGQ9,Tight junction associated protein 1","XP_004044122.1,-;XP_004044119.1,-;XP_004044116.1,tight junction-associated protein 1 isoform X2;XP_004044120.1,-","PF15453,Protein incorporated later into Tight Junctions","IPR028179,Tight junction-associated protein 1","-","GO:0005794,cellular_component,Golgi apparatus;GO:0005923,cellular_component,bicellular tight junction","-"]
["MKRN3",1.86454485,0.628912563,1.558819732,2.987478946,0.002779664,0.006052379,"ENSG00000179455","G3RZ99,Makorin ring finger protein 3","-","PF15815,3 ubiquitin-protein ligase makorin-1, C-terminal;PF00097,Zinc finger, C3HC4 type (RING finger)","-","-","-","-"]
["TBL2",5.155045585,1.745986386,1.558240582,4.198411292,{"v":1.44e-05,"d":"1.44E-05"},{"v":5.3e-05,"d":"5.30E-05"},"ENSG00000106638","A0A0S2Z5F3,Transducin-like 2 isoform 1","-","PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat","-","-","-"]
["ZHX1-C8orf76",20.43053325,6.924208651,1.557436546,4.247975631,{"v":1.15E-5,"d":"1.15E-05"},{"v":4.33e-05,"d":"4.33E-05"},"ENSG00000259305","F6WB42,Uncharacterized protein","-","-","IPR011990,Tetratricopeptide-like helical domain superfamily","-","-","-"]
["NFYC",20.61423632,7.0018232,1.557057063,6.386680565,{"v":4.02e-10,"d":"4.02E-10"},{"v":4.05e-09,"d":"4.05E-09"},"ENSG00000066136","G3QWP0,Nuclear transcription factor Y subunit gamma","-","PF00808,Histone-like transcription factor (CBF/NF-Y) and archaeal histone","IPR027170,Transcriptional activator NFYC/HAP5 subunit;IPR003958,Transcription factor CBF/NF-Y/archaeal histone domain;IPR009072,Histone-fold","-","GO:0032993,cellular_component,protein-DNA complex;GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0000980,molecular_function,RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0046982,molecular_function,protein heterodimerization activity;GO:0090575,cellular_component,RNA polymerase II transcription factor complex;GO:0016602,cellular_component,CCAAT-binding factor complex;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["C1orf50",7.644906123,2.583417438,1.556905117,3.10074824,0.001414816,3.295503E-3,"ENSG00000164008","H2PYT8,Chromosome 1 open reading frame 50","-","PF10504,Protein of unknown function (DUF2452)","IPR019534,Protein of unknown function DUF2452","ENOG410IE7Q,-;ENOG4111ERT,-","GO:0042802,molecular_function,identical protein binding","-"]
["ACD",3.610160446,1.219969389,1.556905117,3.10074824,0.001414816,3.295503E-3,"ENSG00000102977","G3QMR3,ACD, shelterin complex subunit and telomerase recruitment factor","-","PF10341,Shelterin complex subunit, TPP1/ACD","IPR028631,Adrenocortical dysplasia protein","-","GO:0000783,cellular_component,nuclear telomere cap complex;GO:0070187,cellular_component,shelterin complex;GO:0000723,biological_process,telomere maintenance;GO:0016233,biological_process,telomere capping","-"]
["HOXA4",6.660301728,2.250693383,1.556905117,3.10074824,0.001414816,3.295503E-3,"ENSG00000197576","A0A0D9RP69,Homeobox A4","XP_007980003.1,homeobox protein Hox-A4","PF00046,Homeobox domain","IPR009057,Homeobox-like domain superfamily;IPR017995,Homeobox protein, antennapedia type;IPR017970,Homeobox, conserved site;IPR020479,Homeobox domain, metazoa;IPR001827,Homeobox protein, antennapedia type, conserved site;IPR001356,Homeobox domain","-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0007275,biological_process,multicellular organism development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus","-"]
["CCDC102A",10.85216775,3.680185867,1.556687358,4.29588277,{"v":1.16e-05,"d":"1.16E-05"},{"v":4.36e-05,"d":"4.36E-05"},"ENSG00000135736","F6U8Y3,Coiled-coil domain containing 102A","XP_014981736.1,-","PF01576,Myosin tail","IPR002928,Myosin tail","ENOG410XRGB,-;ENOG410II1J,-","GO:0003774,molecular_function,motor activity;GO:0016459,cellular_component,myosin complex","-"]
["AC006460.2",25.75123353,8.737691869,1.55598759,4.342240375,{"v":9.4e-06,"d":"9.40E-06"},{"v":3.6e-05,"d":"3.60E-05"},"ENSG00000228509","H2QJ58,NGFI-A binding protein 1","XP_001166903.1,-;XP_515992.4,-;XP_016805703.1,-;XP_009442163.1,-;XP_016805700.1,-;XP_016805699.1,-;XP_016805701.1,-;XP_016805704.1,-;XP_016805702.1,-","PF04904,NAB conserved region 1 (NCD1);PF04905,NAB conserved region 2 (NCD2);PF04902,Conserved region in Nab1","IPR006986,Nab1, C-terminal;IPR006989,NAB co-repressor, domain;IPR038398,NAB co-repressor domain 2 superfamily;IPR006988,Nab, N-terminal","KOG3835,Transcriptional corepressor NAB1;ENOG410YKFH,-","GO:0005634,cellular_component,nucleus;GO:0045892,biological_process,negative regulation of transcription, DNA-templated","-"]
["ZNF281",6.112355119,2.075090255,1.555332508,4.387145925,{"v":6.15e-06,"d":"6.15E-06"},{"v":2.46e-05,"d":"2.46E-05"},"ENSG00000162702","G1S8W3,Zinc finger protein 281","XP_012357537.1,zinc finger protein 281 isoform X2","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0001047,molecular_function,core promoter binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0048863,biological_process,stem cell differentiation;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003714,molecular_function,transcription corepressor activity;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0010629,biological_process,negative regulation of gene expression;GO:0010172,biological_process,embryonic body morphogenesis;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["ISCA2",4.111528161,1.391579479,1.555280706,3.20564753,9.93175E-4,0.002400234,"ENSG00000165898","H2R991,Iron-sulfur cluster assembly 2","XP_001143075.2,iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X1","PF01521,Iron-sulphur cluster biosynthesis","IPR017870,FeS cluster insertion, C-terminal, conserved site;IPR000361,FeS cluster biogenesis;IPR016092,FeS cluster insertion protein;IPR035903,HesB-like domain superfamily","COG0316,Uncharacterized conserved protein;KOG1119,Mitochondrial Fe-S cluster biosynthesis protein ISA2 (contains a HesB-like domain)","GO:0097428,biological_process,protein maturation by iron-sulfur cluster transfer;GO:0016226,biological_process,iron-sulfur cluster assembly;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0005198,molecular_function,structural molecule activity;GO:0051539,molecular_function,4 iron, 4 sulfur cluster binding;GO:0051537,molecular_function,2 iron, 2 sulfur cluster binding;GO:0005506,molecular_function,iron ion binding;GO:0051604,biological_process,protein maturation;GO:0005739,cellular_component,mitochondrion","-"]
["INTS1",9.145176639,3.10958467,1.555127056,5.819516377,{"v":5.57e-09,"d":"5.57E-09"},{"v":4.33e-08,"d":"4.33E-08"},"ENSG00000164880","K7ATZ5,Integrator complex subunit 1","XP_016812479.1,integrator complex subunit 1 isoform X1","PF12432,Protein of unknown function (DUF3677)","IPR016024,Armadillo-type fold;IPR022145,Domain of unknown function DUF3677","-","GO:0032039,cellular_component,integrator complex;GO:0016180,biological_process,snRNA processing","-"]
["PELI1",7.483592457,2.541873998,1.554717964,4.430687959,{"v":5.03e-06,"d":"5.03E-06"},{"v":2.04e-05,"d":"2.04E-05"},"ENSG00000197329","I3MW04,Pellino E3 ubiquitin protein ligase 1","XP_013212674.1,-","PF04710,Pellino","IPR006800,Pellino family","KOG3842,Adaptor protein Pellino;ENOG410XP3S,-","GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0030890,biological_process,positive regulation of B cell proliferation;GO:0008063,biological_process,Toll signaling pathway;GO:0034145,biological_process,positive regulation of toll-like receptor 4 signaling pathway;GO:0034141,biological_process,positive regulation of toll-like receptor 3 signaling pathway;GO:0042130,biological_process,negative regulation of T cell proliferation;GO:0070936,biological_process,protein K48-linked ubiquitination;GO:0050871,biological_process,positive regulation of B cell activation;GO:0000209,biological_process,protein polyubiquitination;GO:0031398,biological_process,positive regulation of protein ubiquitination;GO:0001819,biological_process,positive regulation of cytokine production;GO:0050868,biological_process,negative regulation of T cell activation;GO:0043331,biological_process,response to dsRNA;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0005634,cellular_component,nucleus;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0032496,biological_process,response to lipopolysaccharide","-"]
["TMED7-TICAM2",8.535316381,2.900454315,1.554140309,4.47294714,{"v":3.35e-06,"d":"3.35E-06"},{"v":1.41e-05,"d":"1.41E-05"},"ENSG00000251201","G7P829,Uncharacterized protein","-","PF13676,TIR domain;PF01105,emp24/gp25L/p24 family/GOLD","IPR015720,TMP21-related;IPR009038,GOLD domain;IPR035897,Toll/interleukin-1 receptor homology (TIR) domain superfamily;IPR036598,GOLD domain superfamily;IPR015718,Transmembrane emp24 domain-containing protein 7;IPR000157,Toll/interleukin-1 receptor homology (TIR) domain","-","GO:0007165,biological_process,signal transduction;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["EIF2AK4",7.328158703,2.493716944,1.554055197,5.898930649,{"v":3.09e-09,"d":"3.09E-09"},{"v":2.54e-08,"d":"2.54E-08"},"ENSG00000128829","H2Q956,Eukaryotic translation initiation factor 2 alpha kinase 4","XP_001140245.1,eIF-2-alpha kinase GCN2 isoform X1","PF00069,Protein kinase domain;PF13393,Histidyl-tRNA synthetase;PF05773,RWD domain;PF12745,Anticodon binding domain of tRNAs","IPR036621,Anticodon-binding domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR006575,RWD domain;IPR016255,eIF-2-alpha kinase Gcn2;IPR024435,Histidyl tRNA synthetase-related domain;IPR000719,Protein kinase domain","COG0124,Histidyl-tRNA synthetase;KOG1035,eIF-2alpha kinase GCN2","GO:0016301,molecular_function,kinase activity;GO:0036492,biological_process,eiF2alpha phosphorylation in response to endoplasmic reticulum stress;GO:0010998,biological_process,regulation of translational initiation by eIF2 alpha phosphorylation;GO:0060733,biological_process,regulation of eIF2 alpha phosphorylation by amino acid starvation;GO:0003743,molecular_function,translation initiation factor activity;GO:0070417,biological_process,cellular response to cold;GO:0016310,biological_process,phosphorylation;GO:0006413,biological_process,translational initiation;GO:0004672,molecular_function,protein kinase activity;GO:0004694,molecular_function,eukaryotic translation initiation factor 2alpha kinase activity;GO:0000077,biological_process,DNA damage checkpoint;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0034198,biological_process,cellular response to amino acid starvation","K16196,ko05162,Measles;K16196,ko05168,Herpes simplex infection;K16196,ko05160,Hepatitis C;K16196,ko04141,Protein processing in endoplasmic reticulum;K16196,ko05169,Epstein-Barr virus infection;K16196,ko05164,Influenza A"]
["AK4",1.786121441,0.605342865,1.553885165,3.303335036,0.000704966,0.001758918,"ENSG00000162433","G3SGF3,Adenylate kinase 4, mitochondrial","XP_004025966.2,-;XP_004025967.2,adenylate kinase 4, mitochondrial isoform X1","PF00406,Adenylate kinase;PF05191,Adenylate kinase, active site lid","IPR007862,Adenylate kinase, active site lid domain;IPR006259,Adenylate kinase subfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR000850,Adenylate kinase/UMP-CMP kinase;IPR028585,Adenylate kinase 4, mitochondrial;IPR036193,Adenylate kinase, active site lid domain superfamily;IPR028586,Adenylate kinase 3/4, mitochondrial;IPR033690,Adenylate kinase, conserved site","-","GO:0046034,biological_process,ATP metabolic process;GO:0016301,molecular_function,kinase activity;GO:0006172,biological_process,ADP biosynthetic process;GO:0046039,biological_process,GTP metabolic process;GO:0016776,molecular_function,phosphotransferase activity, phosphate group as acceptor;GO:0046939,biological_process,nucleotide phosphorylation;GO:0006165,biological_process,nucleoside diphosphate phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0004017,molecular_function,adenylate kinase activity;GO:0005524,molecular_function,ATP binding;GO:0046033,biological_process,AMP metabolic process;GO:0005525,molecular_function,GTP binding;GO:0019205,molecular_function,nucleobase-containing compound kinase activity;GO:0005759,cellular_component,mitochondrial matrix;GO:0004550,molecular_function,nucleoside diphosphate kinase activity;GO:0006139,biological_process,nucleobase-containing compound metabolic process;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0046899,molecular_function,nucleoside triphosphate adenylate kinase activity;GO:0005739,cellular_component,mitochondrion","-"]
["SPATA21",7.272414569,2.472382852,1.553596317,4.513997163,{"v":4.23e-06,"d":"4.23E-06"},{"v":1.75e-05,"d":"1.75E-05"},"ENSG00000187144","A0A096NH21,Spermatogenesis associated 21","-","-","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR011992,EF-hand domain pair","-","GO:0005509,molecular_function,calcium ion binding","-"]
["TACC3",20.62498505,7.027095942,1.552679238,6.511283016,{"v":2.43e-10,"d":"2.43E-10"},{"v":2.56e-09,"d":"2.56E-09"},"ENSG00000013810","H2PCP4,Transforming acidic coiled-coil containing protein 3","-","PF05010,Transforming acidic coiled-coil-containing protein (TACC)","IPR007707,Transforming acidic coiled-coil-containing protein, C-terminal","ENOG410YMFS,-;ENOG410IIVK,-","GO:1902850,biological_process,microtubule cytoskeleton organization involved in mitosis;GO:0007091,biological_process,metaphase/anaphase transition of mitotic cell cycle;GO:0005815,cellular_component,microtubule organizing center;GO:0072686,cellular_component,mitotic spindle;GO:0005829,cellular_component,cytosol;GO:0060236,biological_process,regulation of mitotic spindle organization","-"]
["SLC35B3",6.778225953,2.299930593,1.552673307,3.394743714,0.000645307,1.627105E-3,"ENSG00000124786","A0A024R008,Solute carrier family 35, member B3, isoform CRA_c","XP_016866400.1,-;XP_006715165.1,-;NP_057032.2,adenosine 3'-phospho 5'-phosphosulfate transporter 2;NP_001136013.1,-;XP_005249214.1,-;XP_016866399.1,-","PF08449,UAA transporter family","IPR013657,UAA transporter","COG0697,Permeases of the drug/metabolite transporter (DMT) superfamily;KOG1582,UDP-galactose transporter related protein","GO:0055085,biological_process,transmembrane transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ARHGEF18",9.254661637,3.153136601,1.55172924,5.307831854,{"v":7.41e-08,"d":"7.41E-08"},{"v":4.48e-07,"d":"4.48E-07"},"ENSG00000104880","H2R291,Uncharacterized protein","XP_001145436.2,rho guanine nucleotide exchange factor 18 isoform X6;XP_016790350.1,-;XP_016790351.1,-","PF00621,RhoGEF domain;PF00169,PH domain","IPR000219,Dbl homology (DH) domain;IPR011993,PH-like domain superfamily;IPR037744,ARHGEF18, PH domain;IPR001849,Pleckstrin homology domain;IPR035899,Dbl homology (DH) domain superfamily","ENOG410IR0X,-;ENOG410ZR3G,-","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005622,cellular_component,intracellular;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","-"]
["DCLRE1B",3.917489706,1.330612975,1.551611107,3.480636144,0.000467602,0.00121628,"ENSG00000118655","H2PZQ0,DNA cross-link repair 1B","XP_524804.1,5' exonuclease Apollo isoform X1","PF07522,NA repair metallo-beta-lactamase","IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR011084,DNA repair metallo-beta-lactamase","KOG1361,Predicted hydrolase involved in interstrand cross-link repair;COG1236,Predicted exonuclease of the beta-lactamase fold involved in RNA processing","GO:0035312,molecular_function,5'-3' exodeoxyribonuclease activity;GO:0031848,biological_process,protection from non-homologous end joining at telomere;GO:0000781,cellular_component,chromosome, telomeric region;GO:0010833,biological_process,telomere maintenance via telomere lengthening;GO:0000075,biological_process,cell cycle checkpoint;GO:0016604,cellular_component,nuclear body;GO:0042803,molecular_function,protein homodimerization activity;GO:0008409,molecular_function,5'-3' exonuclease activity;GO:0000784,cellular_component,nuclear chromosome, telomeric region;GO:0044877,molecular_function,protein-containing complex binding;GO:0006303,biological_process,double-strand break repair via nonhomologous end joining;GO:0003684,molecular_function,damaged DNA binding;GO:0031627,biological_process,telomeric loop formation;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0005813,cellular_component,centrosome;GO:0016233,biological_process,telomere capping;GO:0031860,biological_process,telomeric 3' overhang formation;GO:0000723,biological_process,telomere maintenance;GO:0036297,biological_process,interstrand cross-link repair;GO:0005654,cellular_component,nucleoplasm","-"]
["GLB1",3.536872008,1.201332521,1.551611107,3.480636144,0.000467602,0.00121628,"ENSG00000170266","Q53H18,Beta-galactosidase","-","PF13364,Beta-galactosidase jelly roll domain;PF01301,lycosyl hydrolases family 35","IPR001944,Glycoside hydrolase, family 35;IPR031330,Glycoside hydrolase 35, catalytic domain;IPR025300,Beta-galactosidase jelly roll domain;IPR017853,Glycoside hydrolase superfamily;IPR026283,Beta-galactosidase 1-like;IPR019801,Glycoside hydrolase, family 35, conserved site;IPR008979,Galactose-binding-like domain superfamily","KOG0496,Beta-galactosidase;COG1874,Beta-galactosidase","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0005975,biological_process,carbohydrate metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0004565,molecular_function,beta-galactosidase activity;GO:0004553,molecular_function,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0008152,biological_process,metabolic process","-"]
["NRBP1",54.05125844,18.44605621,1.550683114,7.601012411,{"v":8.81e-12,"d":"8.81E-12"},1.28E-10,"ENSG00000115216","G3QFH0,Nuclear receptor binding protein 1","-","PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","-","GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["MROH6",3.717048554,1.263674811,1.550672454,3.561643659,0.000260181,0.00071869,"ENSG00000204839","G3S0R6,Maestro heat like repeat family member 6","-","-","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","-","-","-"]
["BAG4",18.36871991,6.268462663,1.5499832,5.911436912,{"v":4.21e-09,"d":"4.21E-09"},{"v":3.37e-08,"d":"3.37E-08"},"ENSG00000156735","H2QW14,BCL2-associated athanogene 4","-","PF02179,BAG domain","IPR036533,BAG domain superfamily;IPR003103,BAG domain","KOG4361,BCL2-associated athanogene-like proteins and related BAG family chaperone regulators;ENOG4111WNH,-","GO:0051087,molecular_function,chaperone binding;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:1903215,biological_process,negative regulation of protein targeting to mitochondrion;GO:0005634,cellular_component,nucleus","-"]
["ARMCX5",3.529747629,1.20096559,1.549836976,3.638294844,0.000192791,0.000550007,"ENSG00000125962","G3SAY1,Armadillo repeat containing, X-linked 5","XP_018874868.1,armadillo repeat-containing X-linked protein 5;XP_018874869.1,-","PF04826,Armadillo-like","IPR011989,Armadillo-like helical;IPR006911,Armadillo repeat-containing domain;IPR016024,Armadillo-type fold","-","-","-"]
["MGA",6.632363697,2.264740825,1.549359587,6.312528348,{"v":6.67e-10,"d":"6.67E-10"},{"v":6.39e-09,"d":"6.39E-09"},"ENSG00000174197","H2Q985,MAX gene associated","XP_001150813.2,MAX gene-associated protein isoform X3","PF16059,omain of unknown function (DUF4801);PF00907,T-box;PF00010,Helix-loop-helix DNA-binding domain","IPR032060,Domain of unknown function DUF4801;IPR001699,Transcription factor, T-box;IPR036960,T-box superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR018186,Transcription factor, T-box, conserved site;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR037935,MAX gene-associated protein;IPR036638,Helix-loop-helix DNA-binding domain superfamily","KOG3585,TBX2 and related T-box transcription factors;ENOG410XSTS,-","GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0071339,cellular_component,MLL1 complex;GO:0005634,cellular_component,nucleus","-"]
["BCKDHB",4.491385701,1.529257051,1.54908855,3.711036706,1.104E-4,0.000331159,"ENSG00000083123","H2QTB5,Branched chain keto acid dehydrogenase E1 subunit beta","-","PF02779,Transketolase, pyrimidine binding domain;PF02780,Transketolase, C-terminal domain","IPR033248,Transketolase, C-terminal domain;IPR029061,Thiamin diphosphate-binding fold;IPR009014,Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II;IPR005475,Transketolase-like, pyrimidine-binding domain","COG0022,Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit;KOG0525,Branched chain alpha-keto acid dehydrogenase E1, beta subunit","GO:0009083,biological_process,branched-chain amino acid catabolic process;GO:0003824,molecular_function,catalytic activity;GO:0003826,molecular_function,alpha-ketoacid dehydrogenase activity;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0005947,cellular_component,mitochondrial alpha-ketoglutarate dehydrogenase complex","-"]
["CPNE1",50.74328493,17.34581985,1.548106847,6.951904173,5.84E-11,{"v":7e-10,"d":"7.00E-10"},"ENSG00000214078","B0QZ18,Copine-1","NP_003906.2,copine-1 isoform b","PF07002,Copine;PF00168,C2 domain","IPR036465,von Willebrand factor A-like domain superfamily;IPR037768,Copine, C2B domain;IPR010734,Copine;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR002035,von Willebrand factor, type A","ENOG410XPC8,-;KOG1327,Copine","GO:0031965,cellular_component,nuclear membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["ADAM15",7.285381128,2.488331144,1.54783298,5.048471978,{"v":2.82e-07,"d":"2.82E-07"},{"v":1.49e-06,"d":"1.49E-06"},"ENSG00000143537","G3RDF4,ADAM metallopeptidase domain 15","XP_004026898.1,disintegrin and metalloproteinase domain-containing protein 15 isoform X3","PF00200,isintegrin;PF08516,ADAM cysteine-rich;PF01421,Reprolysin (M12B) family zinc metalloprotease;PF01562,Reprolysin family propeptide","IPR033605,ADAM15 peptidase;IPR001590,Peptidase M12B, ADAM/reprolysin;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR001762,Disintegrin domain;IPR034027,Reprolysin domain, adamalysin-type;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR006586,ADAM, cysteine-rich;IPR036436,Disintegrin domain superfamily;IPR002870,Peptidase M12B, propeptide","-","GO:0002418,biological_process,immune response to tumor cell;GO:0006508,biological_process,proteolysis;GO:0009986,cellular_component,cell surface;GO:0060317,biological_process,cardiac epithelial to mesenchymal transition;GO:0045087,biological_process,innate immune response;GO:0070062,cellular_component,extracellular exosome;GO:0008237,molecular_function,metallopeptidase activity;GO:0030336,biological_process,negative regulation of cell migration;GO:0016020,cellular_component,membrane;GO:0046872,molecular_function,metal ion binding;GO:0030308,biological_process,negative regulation of cell growth;GO:0070528,biological_process,protein kinase C signaling;GO:0017124,molecular_function,SH3 domain binding;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0005622,cellular_component,intracellular;GO:1900121,biological_process,negative regulation of receptor binding;GO:0005178,molecular_function,integrin binding;GO:0001953,biological_process,negative regulation of cell-matrix adhesion;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space","-"]
["RRNAD1",6.369237093,2.17132608,1.547803563,3.846264741,{"v":8.1e-05,"d":"8.10E-05"},0.000249966,"ENSG00000143303","K7AQ21,Ribosomal RNA adenine dimethylase domain containing 1","XP_016784816.1,protein RRNAD1 isoform X1","PF13679,Methyltransferase domain","IPR020596,Ribosomal RNA adenine methylase transferase, conserved site;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR025714,Methyltransferase domain","KOG2651,rRNA adenine N-6-methyltransferase;ENOG410XPIU,-","GO:0008649,molecular_function,rRNA methyltransferase activity;GO:0031167,biological_process,rRNA methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0000179,molecular_function,rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0032259,biological_process,methylation;GO:0000154,biological_process,rRNA modification","-"]
["STT3B",21.60451442,7.387463945,1.547299698,6.201829979,{"v":9.69e-10,"d":"9.69E-10"},{"v":8.94e-09,"d":"8.94E-09"},"ENSG00000163527","H2QM84,STT3, subunit of the oligosaccharyltransferase complex, homolog B","-","PF02516,Oligosaccharyl transferase STT3 subunit","IPR003674,Oligosaccharyl transferase, STT3 subunit","KOG2292,Oligosaccharyltransferase, STT3 subunit;COG1287,Uncharacterized membrane protein, required for N-linked glycosylation","GO:0008250,cellular_component,oligosaccharyltransferase complex;GO:0006486,biological_process,protein glycosylation;GO:0043687,biological_process,post-translational protein modification;GO:0004576,molecular_function,oligosaccharyl transferase activity;GO:0018279,biological_process,protein N-linked glycosylation via asparagine;GO:0016020,cellular_component,membrane;GO:0004579,molecular_function,dolichyl-diphosphooligosaccharide-protein glycotransferase activity","K07151,ko04141,Protein processing in endoplasmic reticulum;K07151,ko00513,Various types of N-glycan biosynthesis;K07151,ko00510,N-Glycan biosynthesis"]
["NFS1",3.665968378,1.25103905,1.546740171,3.969793883,{"v":4.8e-05,"d":"4.80E-05"},0.000156564,"ENSG00000244005","Q53FP3,NFS1 nitrogen fixation 1 isoform a variant","NP_001185918.1,cysteine desulfurase, mitochondrial isoform b precursor;NP_066923.3,cysteine desulfurase, mitochondrial isoform a precursor","PF00266,Aminotransferase class-V","IPR010240,Cysteine desulfurase IscS;IPR015424,Pyridoxal phosphate-dependent transferase;IPR016454,Cysteine desulfurase;IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR015422,Pyridoxal phosphate-dependent transferase domain 1;IPR000192,Aminotransferase class V domain;IPR020578,Aminotransferase class-V, pyridoxal-phosphate binding site","COG1104,Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes;KOG1549,Cysteine desulfurase NFS1","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0031071,molecular_function,cysteine desulfurase activity;GO:0003824,molecular_function,catalytic activity;GO:0044571,biological_process,[2Fe-2S] cluster assembly","K04487,ko00730,Thiamine metabolism;K04487,ko04122,Sulfur relay system"]
["C21orf91",3.694247649,1.26125464,1.5462744,4.027774287,{"v":4.69e-05,"d":"4.69E-05"},0.000153551,"ENSG00000154642","G3RN64,Chromosome 21 open reading frame 91","XP_004062658.1,-","PF06937,URL protein","IPR009704,EURL protein","-","-","-"]
["ITGAV",14.80691687,5.067988981,1.54600153,6.367300119,{"v":5.48e-10,"d":"5.48E-10"},{"v":5.38E-9,"d":"5.38E-09"},"ENSG00000138448","L7RXH0,Integrin, alpha V","-","PF01839,-GAP repeat;PF08441,Integrin alpha;PF00357,Integrin alpha cytoplasmic region","IPR013517,FG-GAP repeat;IPR018184,Integrin alpha chain, C-terminal cytoplasmic region, conserved site;IPR032695,Integrin domain superfamily;IPR013649,Integrin alpha-2;IPR013519,Integrin alpha beta-propellor;IPR000413,Integrin alpha chain;IPR028994,Integrin alpha, N-terminal","ENOG410IPB5,-;ENOG410YR19,-","GO:0008305,cellular_component,integrin complex;GO:0070371,biological_process,ERK1 and ERK2 cascade;GO:0001570,biological_process,vasculogenesis;GO:0005102,molecular_function,signaling receptor binding;GO:0005886,cellular_component,plasma membrane;GO:0038044,biological_process,transforming growth factor-beta secretion;GO:0005925,cellular_component,focal adhesion;GO:0007155,biological_process,cell adhesion;GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0001846,molecular_function,opsonin binding;GO:0042277,molecular_function,peptide binding;GO:0033690,biological_process,positive regulation of osteoblast proliferation;GO:0034685,cellular_component,integrin alphav-beta6 complex;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0005829,cellular_component,cytosol;GO:0016021,cellular_component,integral component of membrane;GO:0030335,biological_process,positive regulation of cell migration;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0009897,cellular_component,external side of plasma membrane;GO:0043277,biological_process,apoptotic cell clearance;GO:0001525,biological_process,angiogenesis;GO:0007204,biological_process,positive regulation of cytosolic calcium ion concentration;GO:0016020,cellular_component,membrane;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0005178,molecular_function,integrin binding;GO:0001568,biological_process,blood vessel development;GO:0043410,biological_process,positive regulation of MAPK cascade;GO:0016477,biological_process,cell migration;GO:0034684,cellular_component,integrin alphav-beta5 complex;GO:0033627,biological_process,cell adhesion mediated by integrin;GO:0005080,molecular_function,protein kinase C binding","-"]
["LCOR",4.850963724,1.660839212,1.545604348,6.422077474,{"v":4.55e-10,"d":"4.55E-10"},{"v":4.55e-09,"d":"4.55E-09"},"ENSG00000196233","H2NB58,Ligand dependent nuclear receptor corepressor","-","PF15090,omain of unknown function (DUF4553)","IPR028104,Protein of unknown function DUF4553","ENOG4111MRK,-;ENOG410IHUE,-","-","-"]
["RIN3",2.980900131,1.018877464,1.545082612,4.188826857,{"v":1.81e-05,"d":"1.81E-05"},{"v":6.5e-05,"d":"6.50E-05"},"ENSG00000100599","G3QYN9,Ras and Rab interactor 3","-","PF02204,Vacuolar sorting protein 9 (VPS9) domain","IPR036860,SH2 domain superfamily;IPR037191,VPS9 domain superfamily;IPR000159,Ras-associating (RA) domain;IPR035869,Ras and Rab interactor 3, SH2 domain;IPR000980,SH2 domain;IPR003123,VPS9 domain","-","GO:0007165,biological_process,signal transduction","-"]
["SNX18",3.890448795,1.329762967,1.545082612,4.188826857,{"v":1.81e-05,"d":"1.81E-05"},{"v":6.5e-05,"d":"6.50E-05"},"ENSG00000178996","G1SB44,Sorting nexin 18","-","PF14604,Variant SH3 domain;PF00787,PX domain;PF10456,WASP-binding domain of Sorting nexin protein","-","-","-","-"]
["PPP4R1",12.70386954,4.352189407,1.544532834,6.135356967,{"v":1.72e-09,"d":"1.72E-09"},{"v":1.5e-08,"d":"1.50E-08"},"ENSG00000154845","K7CDT6,Protein phosphatase 4, regulatory subunit 1","XP_016788784.1,serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X3","PF02985,HEAT repeat;PF15017,Putative WW-binding domain and destruction box","IPR031087,Serine/threonine-protein phosphatase 4 regulatory subunit 1;IPR011989,Armadillo-like helical;IPR000357,HEAT repeat;IPR021133,HEAT, type 2;IPR016024,Armadillo-type fold;IPR033461,Putative WW-binding domain and destruction box","ENOG410XQII,-;ENOG410IUDJ,-","GO:0050790,biological_process,regulation of catalytic activity;GO:0030289,cellular_component,protein phosphatase 4 complex;GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0019888,molecular_function,protein phosphatase regulator activity;GO:0007165,biological_process,signal transduction","-"]
["CCNJL",6.267423598,2.144756503,1.543850131,4.378762458,{"v":7.62e-06,"d":"7.62E-06"},{"v":2.98e-05,"d":"2.98E-05"},"ENSG00000135083","H2QRX7,Uncharacterized protein","-","PF02984,Cyclin, C-terminal domain;PF00134,Cyclin, N-terminal domain","IPR004367,Cyclin, C-terminal domain;IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","ENOG410Y1BM,-;ENOG410IEPY,-","GO:0005634,cellular_component,nucleus","-"]
["NRAS",16.118895,5.523658885,1.543729722,5.617150259,{"v":1.54e-08,"d":"1.54E-08"},{"v":1.09E-7,"d":"1.09E-07"},"ENSG00000213281","I3MT44,NRAS proto-oncogene, GTPase","XP_005334962.1,-","PF00071,Ras family","IPR020849,Small GTPase superfamily, Ras type;IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1100,GTPase SAR1 and related small G proteins;KOG0395,Ras-related GTPase","GO:0005794,cellular_component,Golgi apparatus;GO:0005525,molecular_function,GTP binding;GO:0001938,biological_process,positive regulation of endothelial cell proliferation;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0007165,biological_process,signal transduction","-"]
["PICALM",12.4571926,4.269230555,1.543621507,5.635820871,{"v":1.67e-08,"d":"1.67E-08"},{"v":1.17E-7,"d":"1.17E-07"},"ENSG00000073921","A0A024R5P1,Phosphatidylinositol binding clathrin assembly protein, isoform CRA_i","NP_009097.2,phosphatidylinositol-binding clathrin assembly protein isoform 1","PF07651,ANTH domain","IPR011417,AP180 N-terminal homology (ANTH) domain;IPR013809,ENTH  domain;IPR030412,Phosphatidylinositol-binding clathrin assembly protein;IPR014712,Phosphoinositide-binding clathrin adaptor, domain 2;IPR008942,ENTH/VHS","ENOG410XQ90,-;KOG0251,Clathrin assembly protein AP180 and related proteins, contain ENTH domain","GO:0007409,biological_process,axonogenesis;GO:0016188,biological_process,synaptic vesicle maturation;GO:0072583,biological_process,clathrin-dependent endocytosis;GO:0030276,molecular_function,clathrin binding;GO:0048813,biological_process,dendrite morphogenesis;GO:0090647,biological_process,modulation of age-related behavioral decline;GO:1902963,biological_process,negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:0035459,biological_process,cargo loading into vesicle;GO:1900223,biological_process,positive regulation of amyloid-beta clearance;GO:0048268,biological_process,clathrin coat assembly;GO:0005545,molecular_function,1-phosphatidylinositol binding;GO:0006898,biological_process,receptor-mediated endocytosis;GO:0030097,biological_process,hemopoiesis;GO:1902961,biological_process,positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:1902004,biological_process,positive regulation of amyloid-beta formation;GO:0005905,cellular_component,clathrin-coated pit;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0031982,cellular_component,vesicle;GO:0030136,cellular_component,clathrin-coated vesicle;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0005543,molecular_function,phospholipid binding;GO:0007611,biological_process,learning or memory;GO:0005622,cellular_component,intracellular;GO:0006897,biological_process,endocytosis","-"]
["GOLGA1",12.86127386,4.409493114,1.54312035,5.725707699,{"v":1.13E-8,"d":"1.13E-08"},{"v":8.28E-8,"d":"8.28E-08"},"ENSG00000136935","A0A024R869,Golgi autoantigen, golgin subfamily a, 1, isoform CRA_a","NP_002068.1,golgin subfamily A member 1","PF01465,RIP domain","IPR000237,GRIP domain","ENOG410IG17,-;ENOG410ZJU1,-","-","-"]
["ZDBF2",3.329953681,1.140801163,1.542692602,4.585485839,{"v":2.9e-06,"d":"2.90E-06"},{"v":1.24E-5,"d":"1.24E-05"},"ENSG00000204186","N0DVB2,Zinc finger DBF-type containing 2 vesion 1","XP_011509837.1,-;XP_005246769.1,-;XP_011509834.1,-;NP_065974.1,DBF4-type zinc finger-containing protein 2 isoform 1;XP_006712719.1,-;XP_011509835.1,-;XP_005246770.1,-;XP_011509836.1,-;XP_005246768.1,-","PF07535,BF zinc finger","IPR038545,DBF-type zinc finger superfamily;IPR006572,Zinc finger, DBF-type","ENOG410J2NC,-;ENOG410YJEQ,-","GO:0003676,molecular_function,nucleic acid binding;GO:0008270,molecular_function,zinc ion binding","-"]
["CDC42SE1",54.54091769,18.71691285,1.542580099,7.268928057,{"v":2.7E-11,"d":"2.70E-11"},{"v":3.54e-10,"d":"3.54E-10"},"ENSG00000197622","A0A287D6U6,CDC42 small effector 1","XP_005331247.1,-","-","IPR036936,CRIB domain superfamily;IPR000095,CRIB domain","-","-","-"]
["ELF2",4.133360006,1.416302274,1.54249844,4.623483041,{"v":1.99E-6,"d":"1.99E-06"},{"v":8.83e-06,"d":"8.83E-06"},"ENSG00000109381","G1RUX8,E74 like ETS transcription factor 2","XP_012363281.1,ETS-related transcription factor Elf-2 isoform X1","PF12310,Transcription factor protein N terminal;PF00178,ts-domain","IPR022084,Transcription factor Elf, N-terminal;IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000418,Ets domain","ENOG4111K4J,-;KOG3804,Transcription factor NERF and related proteins, contain ETS domain","GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["FNBP4",25.13401222,8.627262904,1.542168682,7.013409527,{"v":5.65e-11,"d":"5.65E-11"},{"v":6.78e-10,"d":"6.78E-10"},"ENSG00000109920","H2Q3J5,Formin binding protein 4","XP_016776353.1,formin-binding protein 4 isoform X1","PF00397,WW domain","IPR001202,WW domain;IPR036020,WW domain superfamily","ENOG4111F8J,-;ENOG410IIQY,-","GO:0016607,cellular_component,nuclear speck","-"]
["WDTC1",6.819489564,2.338899093,1.541522258,4.832500039,{"v":7.44e-07,"d":"7.44E-07"},{"v":3.61e-06,"d":"3.61E-06"},"ENSG00000142784","G1REB6,WD and tetratricopeptide repeats 1","XP_012353966.1,WD and tetratricopeptide repeats protein 1 isoform X1;XP_012353967.1,-","PF00400,WD domain, G-beta repeat","IPR017986,WD40-repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR001680,WD40 repeat;IPR013026,Tetratricopeptide repeat-containing domain","KOG1334,WD40 repeat protein;KOG1310,WD40 repeat protein;ENOG410XWAR,-","GO:0045717,biological_process,negative regulation of fatty acid biosynthetic process;GO:0006006,biological_process,glucose metabolic process;GO:0042826,molecular_function,histone deacetylase binding;GO:0008361,biological_process,regulation of cell size;GO:0042393,molecular_function,histone binding;GO:0035264,biological_process,multicellular organism growth;GO:0001701,biological_process,in utero embryonic development;GO:0043086,biological_process,negative regulation of catalytic activity;GO:0005829,cellular_component,cytosol;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0055082,biological_process,cellular chemical homeostasis;GO:0005634,cellular_component,nucleus;GO:0004857,molecular_function,enzyme inhibitor activity;GO:0032869,biological_process,cellular response to insulin stimulus","-"]
["TPM4",158.5736686,54.49272023,1.540937143,9.627212699,{"v":4.68e-13,"d":"4.68E-13"},{"v":9.16e-12,"d":"9.16E-12"},"ENSG00000167460","A0A146WGE6,Uncharacterized protein","-","-","-","-","-","-"]
["PAM",13.47558139,4.630107465,1.540434543,6.34054779,{"v":7.86e-10,"d":"7.86E-10"},{"v":7.38e-09,"d":"7.38E-09"},"ENSG00000145730","G3R1M8,Peptidylglycine alpha-amidating monooxygenase","XP_018883338.1,-;XP_004042365.1,peptidyl-glycine alpha-amidating monooxygenase isoform X2","PF01436,NHL repeat;PF01082,Copper type II ascorbate-dependent monooxygenase, N-terminal domain;PF03712,Copper type II ascorbate-dependent monooxygenase, C-terminal domain","IPR036939,Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily;IPR001258,NHL repeat;IPR020611,Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site;IPR014784,Copper type II, ascorbate-dependent monooxygenase-like, C-terminal;IPR000720,Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase;IPR008977,PHM/PNGase F domain superfamily;IPR000323,Copper type II, ascorbate-dependent monooxygenase, N-terminal;IPR011042,Six-bladed beta-propeller, TolB-like;IPR024548,Copper type II ascorbate-dependent monooxygenase, C-terminal;IPR013017,NHL repeat, subgroup;IPR014783,Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site","-","GO:0003824,molecular_function,catalytic activity;GO:0001519,biological_process,peptide amidation;GO:0016715,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen;GO:0004497,molecular_function,monooxygenase activity;GO:0006518,biological_process,peptide metabolic process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0008270,molecular_function,zinc ion binding;GO:0005507,molecular_function,copper ion binding;GO:0055114,biological_process,oxidation-reduction process;GO:0004504,molecular_function,peptidylglycine monooxygenase activity;GO:0004598,molecular_function,peptidylamidoglycolate lyase activity","-"]
["FXYD5",107.7416897,37.11256528,1.537303962,7.766539829,{"v":9e-12,"d":"9.00E-12"},{"v":1.31e-10,"d":"1.31E-10"},"ENSG00000089327","F5H4X8,FXYD domain-containing ion transport regulator","NP_001307841.1,FXYD domain-containing ion transport regulator 5 isoform 2 precursor","PF02038,ATP1G1/PLM/MAT8 family","IPR000272,Ion-transport regulator, FXYD motif","-","GO:0005216,molecular_function,ion channel activity;GO:0006811,biological_process,ion transport;GO:0034220,biological_process,ion transmembrane transport;GO:0016020,cellular_component,membrane","-"]
["ZC3H14",3.894088286,1.34333109,1.53431729,5.804145651,{"v":9.99e-09,"d":"9.99E-09"},{"v":7.38e-08,"d":"7.38E-08"},"ENSG00000100722","H2Q8R5,Zinc finger CCCH-type containing 14","XP_009426555.1,-","PF14608,RNA-binding, Nab2-type zinc finger","IPR000571,Zinc finger, CCCH-type","KOG3702,Nuclear polyadenylated RNA binding protein;ENOG410YE77,-","GO:1900364,biological_process,negative regulation of mRNA polyadenylation;GO:0005730,cellular_component,nucleolus;GO:0005737,cellular_component,cytoplasm;GO:0046872,molecular_function,metal ion binding;GO:0032839,cellular_component,dendrite cytoplasm;GO:0008143,molecular_function,poly(A) binding;GO:0016607,cellular_component,nuclear speck;GO:1904115,cellular_component,axon cytoplasm;GO:0005634,cellular_component,nucleus;GO:0030529,,;GO:0043488,biological_process,regulation of mRNA stability","-"]
["STK35",9.962891992,3.436866752,1.534130435,5.591077912,{"v":2.19e-08,"d":"2.19E-08"},{"v":1.49E-7,"d":"1.49E-07"},"ENSG00000125834","H2QJU0,Serine/threonine kinase 35","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0595,Serine/threonine-protein kinase involved in autophagy;ENOG410XR01,-","GO:0005634,cellular_component,nucleus;GO:0006468,biological_process,protein phosphorylation;GO:0016604,cellular_component,nuclear body;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["NECTIN2",13.94214891,4.80957819,1.53366804,5.172012528,{"v":2.07e-07,"d":"2.07E-07"},{"v":1.13E-6,"d":"1.13E-06"},"ENSG00000130202","H2R608,Uncharacterized protein","-","PF08205,CD80-like C2-set immunoglobulin domain;PF07686,Immunoglobulin V-set domain","IPR007110,Immunoglobulin-like domain;IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR033318,Nectin-2;IPR013106,Immunoglobulin V-set domain","ENOG410IIB8,-;ENOG4111FZM,-","GO:0007286,biological_process,spermatid development;GO:0060370,biological_process,susceptibility to T cell mediated cytotoxicity;GO:0005911,cellular_component,cell-cell junction;GO:0050839,molecular_function,cell adhesion molecule binding;GO:0007155,biological_process,cell adhesion;GO:0007157,biological_process,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0005913,cellular_component,cell-cell adherens junction;GO:0042803,molecular_function,protein homodimerization activity;GO:0008037,biological_process,cell recognition;GO:0005102,molecular_function,signaling receptor binding;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0046718,biological_process,viral entry into host cell;GO:0042271,biological_process,susceptibility to natural killer cell mediated cytotoxicity;GO:0004872,-,-;GO:0046982,molecular_function,protein heterodimerization activity;GO:0016020,cellular_component,membrane;GO:0002860,biological_process,positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["TOMM70",9.521327526,3.284541681,1.533634702,5.146179042,{"v":2.35E-7,"d":"2.35E-07"},{"v":1.27e-06,"d":"1.27E-06"},"ENSG00000154174","H2P9W6,Translocase of outer mitochondrial membrane 70","XP_002813404.1,mitochondrial import receptor subunit TOM70","PF00515,Tetratricopeptide repeat;PF13181,Tetratricopeptide repeat","IPR001440,Tetratricopeptide repeat 1;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","ENOG410YVNZ,-;KOG0547,Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72","GO:0005739,cellular_component,mitochondrion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["OTUD5",10.84172156,3.740033755,1.533053569,4.759737107,{"v":1.49e-06,"d":"1.49E-06"},{"v":6.8e-06,"d":"6.80E-06"},"ENSG00000068308","A0A024QZ09,OTU domain containing 5, isoform CRA_d","NP_060072.1,OTU domain-containing protein 5 isoform a;XP_006724600.1,-","PF02338,OTU-like cysteine protease","IPR003323,OTU domain;IPR031084,OTU domain-containing protein 5/Otubain-like deubiquitinase 1","ENOG410XNYW,-;KOG2605,OTU (ovarian tumor)-like cysteine protease","GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0016579,biological_process,protein deubiquitination","K12655,ko04622,RIG-I-like receptor signaling pathway"]
["TMEM237",4.720013349,1.628247798,1.5328631,4.653590535,{"v":2.02e-06,"d":"2.02E-06"},{"v":8.97e-06,"d":"8.97E-06"},"ENSG00000155755","H2RDU7,Amyotrophic lateral sclerosis 2","XP_001156617.2,transmembrane protein 237 isoform X1","PF15383,Transmembrane protein 237","IPR029409,Transmembrane protein 237","ENOG41124J8,-;ENOG410IHCQ,-","GO:0030111,biological_process,regulation of Wnt signaling pathway;GO:0060271,biological_process,cilium assembly;GO:0035869,cellular_component,ciliary transition zone;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SLC25A32",9.098089858,3.138538746,1.532640044,4.538965445,{"v":4.28e-06,"d":"4.28E-06"},{"v":1.77E-5,"d":"1.77E-05"},"ENSG00000164933","A0A024R9D0,Solute carrier family 25, member 32, isoform CRA_a","NP_110407.2,mitochondrial folate transporter/carrier","PF00153,Mitochondrial carrier protein","IPR018108,Mitochondrial substrate/solute carrier;IPR023395,Mitochondrial carrier domain superfamily;IPR002030,Mitochondrial carrier UCP-like","KOG0764,Mitochondrial FAD carrier protein;ENOG410XPAJ,-","GO:0031966,cellular_component,mitochondrial membrane;GO:0016020,cellular_component,membrane;GO:0005739,cellular_component,mitochondrion;GO:0016021,cellular_component,integral component of membrane;GO:0006839,biological_process,mitochondrial transport","-"]
["PCIF1",10.03248828,3.460875158,1.532556963,4.498628175,{"v":6.35e-06,"d":"6.35E-06"},{"v":2.52e-05,"d":"2.52E-05"},"ENSG00000100982","H2P253,Uncharacterized protein","XP_009231936.1,phosphorylated CTD-interacting factor 1 isoform X1","PF00397,WW domain;PF12237,Phosphorylated CTD interacting factor 1 WW domain","IPR022035,Phosphorylated CTD interacting factor 1, WW domain;IPR001202,WW domain;IPR036020,WW domain superfamily","ENOG410IFAY,-;ENOG410XPH2,-","GO:0045171,cellular_component,intercellular bridge;GO:0005654,cellular_component,nucleoplasm;GO:0010923,biological_process,negative regulation of phosphatase activity;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["PRDM11",1.837874136,0.634005519,1.53180353,4.179176046,{"v":2.28e-05,"d":"2.28E-05"},{"v":8.01e-05,"d":"8.01E-05"},"ENSG00000019485","A0A087WWZ6,PR domain-containing protein 11","XP_011518527.1,-;XP_011518525.1,-;XP_011518524.1,-;NP_001243624.1,PR domain-containing protein 11 isoform 1;XP_011518526.1,-","-","IPR001214,SET domain","ENOG410IN44,-;ENOG410ZHQ1,-","-","-"]
["DHX34",4.00213728,1.380604403,1.531346483,4.016952295,{"v":5.95e-05,"d":"5.95E-05"},0.000189621,"ENSG00000134815","H2QZD9,DEAH","XP_016791821.1,probable ATP-dependent RNA helicase DHX34","PF00271,Helicase conserved C-terminal domain;PF07717,Oligonucleotide/oligosaccharide-binding (OB)-fold;PF04408,Helicase associated domain (HA2)","IPR011709,Domain of unknown function DUF1605;IPR007502,Helicase-associated domain;IPR001650,Helicase, C-terminal;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0922,DEAH-box RNA helicase;COG1643,HrpA-like helicases","GO:0004386,molecular_function,helicase activity;GO:0004004,molecular_function,ATP-dependent RNA helicase activity;GO:0005737,cellular_component,cytoplasm;GO:2000623,biological_process,negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function,RNA binding;GO:0016787,molecular_function,hydrolase activity;GO:0006396,biological_process,RNA processing;GO:0000956,biological_process,nuclear-transcribed mRNA catabolic process;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["ZNF654",3.219324103,1.110559864,1.531167719,3.958515609,{"v":4.8e-05,"d":"4.80E-05"},0.000156564,"ENSG00000175105","A0A1B0GWA0,Zinc finger protein 654","XP_016862279.1,-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["ZBTB4",15.31125651,5.295246664,1.530822195,6.001471632,{"v":3.77E-9,"d":"3.77E-09"},{"v":3.05e-08,"d":"3.05E-08"},"ENSG00000174282","H2QC42,Zinc finger and BTB domain containing 4","XP_016786946.1,-;XP_511299.3,-;XP_009430022.1,-;XP_009430020.1,-;XP_003315402.1,zinc finger and BTB domain-containing protein 4;XP_009430021.1,-","PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0019901,molecular_function,protein kinase binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0016604,cellular_component,nuclear body;GO:0008327,molecular_function,methyl-CpG binding;GO:0010428,molecular_function,methyl-CpNpG binding;GO:0005829,cellular_component,cytosol;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["C6orf106",49.30780868,17.06355449,1.530479892,7.247912425,{"v":4.06e-11,"d":"4.06E-11"},{"v":5.05e-10,"d":"5.05E-10"},"ENSG00000196821","A0A0D9RBS3,Chromosome 6 open reading frame 106","XP_007971074.1,-","PF14555,UBA-like domain;PF16158,Ig-like domain from next to BRCA1 gene","IPR032350,Next to BRCA1, central domain;IPR009060,UBA-like superfamily;IPR013783,Immunoglobulin-like fold","-","-","-"]
["TYK2",2.664546145,0.919179899,1.53026519,3.697470153,1.44046E-4,0.000422091,"ENSG00000105397","A0A024R7E4,Tyrosine-protein kinase","XP_011526547.1,-;NP_003322.3,non-receptor tyrosine-protein kinase TYK2","PF07714,Protein tyrosine kinase","IPR016045,Tyrosine-protein kinase, non-receptor, TYK2, N-terminal;IPR036860,SH2 domain superfamily;IPR016251,Tyrosine-protein kinase, non-receptor Jak/Tyk2;IPR000299,FERM domain;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR000980,SH2 domain;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0197,Tyrosine kinases","GO:0016301,molecular_function,kinase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0035556,biological_process,intracellular signal transduction;GO:0016740,molecular_function,transferase activity;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0016310,biological_process,phosphorylation;GO:0004715,molecular_function,non-membrane spanning protein tyrosine kinase activity;GO:0005856,cellular_component,cytoskeleton;GO:0004672,molecular_function,protein kinase activity;GO:0016020,cellular_component,membrane;GO:0031702,molecular_function,type 1 angiotensin receptor binding;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","K11219,ko04630,Jak-STAT signaling pathway;K11219,ko05169,Epstein-Barr virus infection;K11219,ko05145,Toxoplasmosis;K11219,ko05164,Influenza A;K11219,ko05160,Hepatitis C;K11219,ko05168,Herpes simplex infection;K11219,ko05162,Measles;K11219,ko04380,Osteoclast differentiation"]
["RP4-758J18.2",6.771140776,2.335818618,1.529977127,3.624003316,0.000252326,0.000699636,"ENSG00000224870","G2HJ44,Uncharacterized protein","-","-","-","-","-","-"]
["VAMP4",3.129926319,1.079720598,1.529655314,3.54654529,0.000341983,0.000918175,"ENSG00000117533","A0A286Y0P0,Vesicle associated membrane protein 4","XP_003474699.2,vesicle-associated membrane protein 4","-","IPR016444,Synaptobrevin/Vesicle-associated membrane protein;IPR001388,Synaptobrevin","-","GO:0016192,biological_process,vesicle-mediated transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GNAQ",10.71060242,3.707159207,1.529333602,5.60654369,{"v":2E-8,"d":"2.00E-08"},{"v":1.37E-7,"d":"1.37E-07"},"ENSG00000156052","H0X055,G protein subunit alpha q","XP_003783014.1,-","PF00503,-protein alpha subunit","IPR011025,G protein alpha subunit, helical insertion;IPR000654,G-protein alpha subunit, group Q;IPR001019,Guanine nucleotide binding protein (G-protein), alpha subunit;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410XNVQ,-;KOG0085,G protein subunit Galphaq/Galphay, small G protein superfamily","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0007213,biological_process,G-protein coupled acetylcholine receptor signaling pathway;GO:0007189,biological_process,adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0016020,cellular_component,membrane;GO:0009791,biological_process,post-embryonic development;GO:0060158,biological_process,phospholipase C-activating dopamine receptor signaling pathway;GO:0007603,biological_process,phototransduction, visible light;GO:0005096,molecular_function,GTPase activator activity;GO:0016322,biological_process,neuron remodeling;GO:0035412,-,-;GO:0050821,biological_process,protein stabilization;GO:0007507,biological_process,heart development;GO:0001501,biological_process,skeletal system development;GO:0042711,biological_process,maternal behavior;GO:0005525,molecular_function,GTP binding;GO:0001508,biological_process,action potential;GO:0003924,molecular_function,GTPase activity;GO:0007215,biological_process,glutamate receptor signaling pathway;GO:0030425,cellular_component,dendrite;GO:0004871,molecular_function,signal transducer activity;GO:0019001,molecular_function,guanyl nucleotide binding;GO:0001750,cellular_component,photoreceptor outer segment;GO:0042733,biological_process,embryonic digit morphogenesis;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0031683,molecular_function,G-protein beta/gamma-subunit complex binding;GO:0000166,molecular_function,nucleotide binding;GO:0045634,biological_process,regulation of melanocyte differentiation;GO:0007165,biological_process,signal transduction;GO:0001664,molecular_function,G-protein coupled receptor binding;GO:0048066,biological_process,developmental pigmentation;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0009649,biological_process,entrainment of circadian clock;GO:0021884,biological_process,forebrain neuron development;GO:0005622,cellular_component,intracellular;GO:0044297,cellular_component,cell body","-"]
["POLR2J4",2.040199933,0.703801198,1.529293451,3.464634392,0.000616405,0.001558738,"ENSG00000272655","B4DJG3,cDNA FLJ58900, weakly similar to Uroplakin-3B","-","-","IPR024831,Uroplakin-3;IPR024827,Uroplakin-3b-like 1/2","ENOG41123W4,-;ENOG410IW5D,-","-","-"]
["POLR3B",2.932813651,1.011723276,1.528883566,3.377723633,0.000854382,0.002094376,"ENSG00000013503","G7PI40,DNA-directed RNA polymerase subunit beta","XP_005572164.1,-","PF04565,RNA polymerase Rpb2, domain 3;PF04560,RNA polymerase Rpb2, domain 7;PF04567,RNA polymerase Rpb2, domain 5;PF00562,RNA polymerase Rpb2, domain 6;PF04566,RNA polymerase Rpb2, domain 4;PF04561,RNA polymerase Rpb2, domain 2;PF04563,RNA polymerase beta subunit","IPR014724,RNA polymerase Rpb2, OB-fold;IPR037033,DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily;IPR037034,RNA polymerase Rpb2, domain 2 superfamily;IPR007641,RNA polymerase Rpb2, domain 7;IPR015712,DNA-directed RNA polymerase, subunit 2;IPR007646,RNA polymerase Rpb2, domain 4;IPR007120,DNA-directed RNA polymerase, subunit 2, hybrid-binding domain;IPR007645,RNA polymerase Rpb2, domain 3;IPR007647,RNA polymerase Rpb2, domain 5;IPR007644,RNA polymerase, beta subunit, protrusion;IPR007121,RNA polymerase, beta subunit, conserved site;IPR007642,RNA polymerase Rpb2, domain 2","-","GO:0032728,biological_process,positive regulation of interferon-beta production;GO:0003677,molecular_function,DNA binding;GO:0045089,biological_process,positive regulation of innate immune response;GO:0016740,molecular_function,transferase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0032549,molecular_function,ribonucleoside binding;GO:0005666,cellular_component,DNA-directed RNA polymerase III complex","K03021,ko05169,Epstein-Barr virus infection;K03021,ko00230,Purine metabolism;K03021,ko04623,Cytosolic DNA-sensing pathway;K03021,ko00240,Pyrimidine metabolism;K03021,ko03020,RNA polymerase"]
["MBD6",11.56598299,4.004388542,1.528799522,5.488220543,{"v":3.91e-08,"d":"3.91E-08"},{"v":2.53E-7,"d":"2.53E-07"},"ENSG00000166987","A0A024RBA3,Methyl-CpG binding domain protein 6, isoform CRA_a","NP_443129.3,methyl-CpG-binding domain protein 6","-","IPR001739,Methyl-CpG DNA binding;IPR037385,Methyl-CpG-binding domain protein 5/6;IPR016177,DNA-binding domain superfamily","ENOG4111KTI,-;ENOG410IJ20,-","GO:0001650,cellular_component,fibrillar center;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["IP6K1",2.557263103,0.882170814,1.528415419,3.285158297,0.000704966,0.001758918,"ENSG00000176095","A0A024R2X2,Kinase","NP_001229758.1,-;NP_695005.1,inositol hexakisphosphate kinase 1 isoform 1","PF03770,Inositol polyphosphate kinase","IPR005522,Inositol polyphosphate kinase;IPR038286,Inositol polyphosphate kinase superfamily","KOG1620,Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex;ENOG410YB60,-","GO:0016301,molecular_function,kinase activity;GO:0032958,biological_process,inositol phosphate biosynthetic process;GO:0005737,cellular_component,cytoplasm;GO:0005634,cellular_component,nucleus;GO:0016740,molecular_function,transferase activity;GO:0001650,cellular_component,fibrillar center;GO:0005829,cellular_component,cytosol;GO:0016310,biological_process,phosphorylation","K07756,ko04070,Phosphatidylinositol signaling system"]
["FOXA1",3.100936101,1.069719936,1.527875639,3.186145632,0.001339119,0.003132788,"ENSG00000129514","H2Q874,Forkhead box A1","-","PF00250,orkhead domain;PF08430,orkhead N-terminal region;PF09354,HNF3 C-terminal domain","IPR018533,Forkhead box protein, C-terminal;IPR013638,Fork-head N-terminal;IPR018122,Fork head domain conserved site1;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR001766,Fork head domain;IPR030456,Fork head domain conserved site 2;IPR036390,Winged helix DNA-binding domain superfamily","COG5025,Transcription factor of the Forkhead/HNF3 family;KOG3563,Forkhead/HNF-3-related transcription factor","GO:0019904,molecular_function,protein domain specific binding;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0030154,biological_process,cell differentiation;GO:0008134,molecular_function,transcription factor binding;GO:0009653,biological_process,anatomical structure morphogenesis;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated","-"]
["WNT7A",2.696642838,0.930252192,1.527875639,3.186145632,0.001339119,0.003132788,"ENSG00000154764","Q1KYK8,Protein Wnt","-","PF00110,wnt family","IPR013300,Wnt-7 protein;IPR018161,Wnt protein, conserved site;IPR005817,Wnt","-","GO:0016055,biological_process,Wnt signaling pathway;GO:0005578,,;GO:0007275,biological_process,multicellular organism development;GO:0005576,cellular_component,extracellular region;GO:0005102,molecular_function,signaling receptor binding","-"]
["TPBG",7.807568508,2.70521674,1.527393723,5.217676095,{"v":1.61E-7,"d":"1.61E-07"},{"v":9.02E-7,"d":"9.02E-07"},"ENSG00000146242","H2QTB7,Trophoblast glycoprotein","XP_016811400.1,trophoblast glycoprotein;XP_016811401.1,-","PF01463,Leucine rich repeat C-terminal domain;PF13855,Leucine rich repeat;PF01462,Leucine rich repeat N-terminal domain","IPR001611,Leucine-rich repeat;IPR000372,Leucine-rich repeat N-terminal domain;IPR003591,Leucine-rich repeat, typical subtype;IPR000483,Cysteine-rich flanking region, C-terminal;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0005737,cellular_component,cytoplasm;GO:0051965,biological_process,positive regulation of synapse assembly;GO:0016021,cellular_component,integral component of membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane","-"]
["DPH3",3.199912121,1.103863375,1.527246421,3.079713067,1.917839E-3,0.004351301,"ENSG00000154813","F7GSP1,DPH3 homolog isoform 1","NP_001247449.1,-","PF05207,CSL zinc finger","IPR007872,Zinc finger, DPH-type;IPR036671,DPH Zinc finger superfamily","COG5216,Uncharacterized conserved protein;KOG2923,Uncharacterized conserved protein","GO:0005737,cellular_component,cytoplasm;GO:0051099,biological_process,positive regulation of binding;GO:0046872,molecular_function,metal ion binding;GO:0050709,biological_process,negative regulation of protein secretion;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["WSB2",11.06021041,3.833151221,1.52694455,5.141271245,{"v":2.76e-07,"d":"2.76E-07"},{"v":1.46E-6,"d":"1.46E-06"},"ENSG00000176871","G3QJE7,WD repeat and SOCS box containing 2","-","PF00400,WD domain, G-beta repeat;PF07525,SOCS box","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036036,SOCS box-like domain superfamily;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat;IPR001496,SOCS box domain","-","GO:0016567,biological_process,protein ubiquitination;GO:0005622,cellular_component,intracellular;GO:0035556,biological_process,intracellular signal transduction","-"]
["TMEM80",2.566506115,0.885359346,1.526503529,2.964649343,0.003778445,0.007998753,"ENSG00000177042","E9PQJ9,Transmembrane protein 80","-","PF09799,Predicted membrane protein","IPR019184,Uncharacterised protein family, transmembrane-17","ENOG4112C55,-;ENOG410J0JJ,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ARSB",1.453365752,0.501362901,1.526503529,2.964649343,0.003778445,0.007998753,"ENSG00000113273","A0A024RAJ9,Arylsulfatase B, isoform CRA_a","NP_000037.2,arylsulfatase B isoform 1 precursor;XP_011541692.1,-","PF00884,Sulfatase","IPR024607,Sulfatase, conserved site;IPR000917,Sulfatase, N-terminal;IPR017850,Alkaline-phosphatase-like, core domain superfamily;IPR017849,Alkaline phosphatase-like, alpha/beta/alpha","KOG3867,Sulfatase;COG3119,Arylsulfatase A and related enzymes","GO:0051597,biological_process,response to methylmercury;GO:0005794,cellular_component,Golgi apparatus;GO:0009268,biological_process,response to pH;GO:0006914,biological_process,autophagy;GO:0003824,molecular_function,catalytic activity;GO:0009986,cellular_component,cell surface;GO:0005764,cellular_component,lysosome;GO:0007584,biological_process,response to nutrient;GO:0010976,biological_process,positive regulation of neuron projection development;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0008484,molecular_function,sulfuric ester hydrolase activity;GO:0007417,biological_process,central nervous system development;GO:0043627,biological_process,response to estrogen;GO:0005791,cellular_component,rough endoplasmic reticulum","K01135,ko00531,Glycosaminoglycan degradation;K01135,ko04142,Lysosome"]
["RP11-571M6.15",13.98881563,4.825676658,1.525613099,2.839419391,0.003182373,6.831256E-3,"ENSG00000257921","H0YIG0,Uncharacterized protein","-","PF10294,Lysine methyltransferase","IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR019410,Lysine methyltransferase","-","-","-"]
["ZNF789",1.421278739,0.490293947,1.525613099,2.839419391,0.003182373,6.831256E-3,"ENSG00000198556","H2R3J8,Uncharacterized protein","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005654,cellular_component,nucleoplasm","-"]
["KITLG",1.415325369,0.488240233,1.524526334,2.702037567,0.006606612,0.013163329,"ENSG00000049130","H2Q6K8,Kit ligand","XP_509255.2,-","PF02404,Stem cell factor","IPR009079,Four-helical cytokine-like, core;IPR003452,Stem cell factor","ENOG410IF3Y,-;ENOG410XYQR,-","GO:0001755,biological_process,neural crest cell migration;GO:0008083,molecular_function,growth factor activity;GO:0002763,biological_process,positive regulation of myeloid leukocyte differentiation;GO:0070668,biological_process,positive regulation of mast cell proliferation;GO:0005886,cellular_component,plasma membrane;GO:0005615,cellular_component,extracellular space;GO:0007155,biological_process,cell adhesion;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0045636,biological_process,positive regulation of melanocyte differentiation;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0030027,cellular_component,lamellipodium;GO:0008584,biological_process,male gonad development;GO:0043406,biological_process,positive regulation of MAP kinase activity;GO:0016021,cellular_component,integral component of membrane;GO:0033026,biological_process,negative regulation of mast cell apoptotic process;GO:0035234,biological_process,ectopic germ cell programmed cell death;GO:0030175,cellular_component,filopodium;GO:0005173,molecular_function,stem cell factor receptor binding;GO:0035162,biological_process,embryonic hemopoiesis;GO:0008284,biological_process,positive regulation of cell proliferation;GO:1902035,biological_process,positive regulation of hematopoietic stem cell proliferation;GO:0016020,cellular_component,membrane;GO:0046579,biological_process,positive regulation of Ras protein signal transduction;GO:0005125,molecular_function,cytokine activity;GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0045740,biological_process,positive regulation of DNA replication;GO:0002687,biological_process,positive regulation of leukocyte migration","-"]
["KAT6B",7.318734328,2.543059574,1.524078681,6.066559048,{"v":3.49e-09,"d":"3.49E-09"},{"v":2.84E-8,"d":"2.84E-08"},"ENSG00000156650","B2RWN8,Histone acetyltransferase","NP_001243397.1,histone acetyltransferase KAT6B isoform 2;NP_001243398.1,histone acetyltransferase KAT6B isoform 3;NP_036462.2,histone acetyltransferase KAT6B isoform 1","PF00628,PHD-finger;PF01853,MOZ/SAS family","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR005818,Linker histone H1/H5, domain H15;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR036390,Winged helix DNA-binding domain superfamily;IPR016181,Acyl-CoA N-acyltransferase;IPR002717,Histone acetyltransferase domain, MYST-type","COG5027,Histone acetyltransferase (MYST family);KOG2747,Histone acetyltransferase (MYST family)","GO:0000786,cellular_component,nucleosome;GO:0003677,molecular_function,DNA binding;GO:0004402,molecular_function,histone acetyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0006334,biological_process,nucleosome assembly;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0016573,biological_process,histone acetylation;GO:0005634,cellular_component,nucleus","-"]
["SOS1",10.48485366,3.643456207,1.52396775,6.052735427,{"v":3.72E-9,"d":"3.72E-09"},{"v":3.02e-08,"d":"3.02E-08"},"ENSG00000115904","A0A0D9RIV8,SOS Ras/Rac guanine nucleotide exchange factor 1","XP_007969062.1,-","PF00618,RasGEF N-terminal motif;PF00621,RhoGEF domain;PF00125,Core histone H2A/H2B/H3/H4;PF00617,RasGEF domain;PF00169,PH domain","IPR000651,Ras-like guanine nucleotide exchange factor, N-terminal;IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR035899,Dbl homology (DH) domain superfamily;IPR007125,Histone H2A/H2B/H3;IPR011993,PH-like domain superfamily;IPR001849,Pleckstrin homology domain;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily;IPR019804,Ras guanine-nucleotide exchange factor, conserved site;IPR009072,Histone-fold;IPR000219,Dbl homology (DH) domain;IPR023578,Ras guanine nucleotide exchange factor domain superfamily","-","GO:0003007,biological_process,heart morphogenesis;GO:0005088,molecular_function,Ras guanyl-nucleotide exchange factor activity;GO:0001942,biological_process,hair follicle development;GO:0035264,biological_process,multicellular organism growth;GO:0046982,molecular_function,protein heterodimerization activity;GO:0048514,biological_process,blood vessel morphogenesis;GO:1904693,biological_process,midbrain morphogenesis;GO:0002260,biological_process,lymphocyte homeostasis;GO:0060021,biological_process,roof of mouth development;GO:0005737,cellular_component,cytoplasm;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0065009,biological_process,regulation of molecular function;GO:0061029,biological_process,eyelid development in camera-type eye;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0003209,biological_process,cardiac atrium morphogenesis;GO:0003677,molecular_function,DNA binding;GO:0003344,biological_process,pericardium morphogenesis;GO:0042129,biological_process,regulation of T cell proliferation;GO:0033081,biological_process,regulation of T cell differentiation in thymus;GO:0007296,biological_process,vitellogenesis;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0061384,biological_process,heart trabecula morphogenesis;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:2000973,biological_process,regulation of pro-B cell differentiation;GO:0001782,biological_process,B cell homeostasis","K03099,ko04917,Prolactin signaling pathway;K03099,ko04062,Chemokine signaling pathway;K03099,ko05200,Pathways in cancer;K03099,ko04540,Gap junction;K03099,ko04012,ErbB signaling pathway;K03099,ko05213,Endometrial cancer;K03099,ko04510,Focal adhesion;K03099,ko05220,Chronic myeloid leukemia;K03099,ko04910,Insulin signaling pathway;K03099,ko04915,Estrogen signaling pathway;K03099,ko04013,MAPK signaling pathway - fly;K03099,ko04664,Fc epsilon RI signaling pathway;K03099,ko04662,B cell receptor signaling pathway;K03099,ko05160,Hepatitis C;K03099,ko05215,Prostate cancer;K03099,ko04630,Jak-STAT signaling pathway;K03099,ko05205,Proteoglycans in cancer;K03099,ko05221,Acute myeloid leukemia;K03099,ko01522,Endocrine resistance;K03099,ko04320,Dorso-ventral axis formation;K03099,ko05034,Alcoholism;K03099,ko04151,PI3K-Akt signaling pathway;K03099,ko01521,EGFR tyrosine kinase inhibitor resistance;K03099,ko04150,mTOR signaling pathway;K03099,ko04912,GnRH signaling pathway;K03099,ko05214,Glioma;K03099,ko04660,T cell receptor signaling pathway;K03099,ko04072,Phospholipase D signaling pathway;K03099,ko05223,Non-small cell lung cancer;K03099,ko04722,Neurotrophin signaling pathway;K03099,ko04068,FoxO signaling pathway;K03099,ko05211,Renal cell carcinoma;K03099,ko04650,Natural killer cell mediated cytotoxicity;K03099,ko04810,Regulation of actin cytoskeleton;K03099,ko04010,MAPK signaling pathway;K03099,ko05231,Choline metabolism in cancer;K03099,ko04014,Ras signaling pathway;K03099,ko05206,MicroRNAs in cancer"]
["CARM1",15.03114724,5.222021235,1.523883314,5.524999309,{"v":4.34e-08,"d":"4.34E-08"},{"v":2.77e-07,"d":"2.77E-07"},"ENSG00000142453","F7FM77,Coactivator associated arginine methyltransferase 1","-","PF06325,Ribosomal protein L11 methyltransferase (PrmA);PF11531,Coactivator-associated arginine methyltransferase 1 N terminal","IPR020989,Histone-arginine methyltransferase CARM1, N-terminal;IPR025799,Protein arginine N-methyltransferase;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR011993,PH-like domain superfamily","ENOG410XPDD,-;KOG1500,Protein arginine N-methyltransferase CARM1","GO:0008469,molecular_function,histone-arginine N-methyltransferase activity;GO:0003420,biological_process,regulation of growth plate cartilage chondrocyte proliferation;GO:0034969,biological_process,histone arginine methylation;GO:0070577,molecular_function,lysine-acetylated histone binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0035246,biological_process,peptidyl-arginine N-methylation;GO:0060350,biological_process,endochondral bone morphogenesis;GO:0034970,biological_process,histone H3-R2 methylation;GO:0005634,cellular_component,nucleus;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity;GO:0071168,biological_process,protein localization to chromatin;GO:0045600,biological_process,positive regulation of fat cell differentiation;GO:0042054,molecular_function,histone methyltransferase activity;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0019919,biological_process,peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0008276,molecular_function,protein methyltransferase activity;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0006479,biological_process,protein methylation;GO:0032259,biological_process,methylation;GO:0005829,cellular_component,cytosol;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity;GO:0016571,biological_process,histone methylation;GO:0034971,biological_process,histone H3-R17 methylation;GO:0016740,molecular_function,transferase activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0090575,cellular_component,RNA polymerase II transcription factor complex;GO:0005654,cellular_component,nucleoplasm;GO:0033146,biological_process,regulation of intracellular estrogen receptor signaling pathway;GO:0035642,molecular_function,histone methyltransferase activity (H3-R17 specific);GO:0030518,biological_process,intracellular steroid hormone receptor signaling pathway;GO:0003713,molecular_function,transcription coactivator activity;GO:0035242,molecular_function,protein-arginine omega-N asymmetric methyltransferase activity;GO:0032091,biological_process,negative regulation of protein binding;GO:0001105,molecular_function,RNA polymerase II transcription coactivator activity;GO:0030520,biological_process,intracellular estrogen receptor signaling pathway;GO:0008168,molecular_function,methyltransferase activity;GO:0016274,molecular_function,protein-arginine N-methyltransferase activity","-"]
["DIS3L",6.596115147,2.290509734,1.523349428,4.646646387,{"v":2.46e-06,"d":"2.46E-06"},{"v":1.07e-05,"d":"1.07E-05"},"ENSG00000166938","H2Q9N0,DIS3 mitotic control homolog-like","XP_001174669.1,DIS3-like exonuclease 1 isoform X1","PF17215,S1 domain;PF17216,Rrp44-like cold shock domain;PF00773,RNB domain","IPR033771,Rrp44-like cold shock domain;IPR033770,Exosome complex exonuclease RRP44, S1 domain;IPR022966,Ribonuclease II/R, conserved site;IPR031192,DIS3-like exonuclease 1;IPR012340,Nucleic acid-binding, OB-fold","KOG2102,Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3;COG0557,Exoribonuclease R","GO:0019899,molecular_function,enzyme binding;GO:0090503,biological_process,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0000177,cellular_component,cytoplasmic exosome (RNase complex);GO:0006401,biological_process,RNA catabolic process;GO:0005886,cellular_component,plasma membrane;GO:0000175,molecular_function,3'-5'-exoribonuclease activity;GO:0005813,cellular_component,centrosome;GO:0000178,cellular_component,exosome (RNase complex);GO:0005829,cellular_component,cytosol;GO:0016075,biological_process,rRNA catabolic process;GO:0006364,biological_process,rRNA processing","-"]
["OXCT1",8.096519021,2.81256176,1.522674999,4.570875586,{"v":4.32e-06,"d":"4.32E-06"},{"v":1.79e-05,"d":"1.79E-05"},"ENSG00000083720","A0A024R040,Succinyl-CoA:3-ketoacid-coenzyme A transferase","NP_000427.1,3-ketoacid coenzyme A transferase 1, mitochondrial precursor","PF01144,Coenzyme A transferase","IPR012791,3-oxoacid CoA-transferase, subunit B;IPR014388,3-oxoacid CoA-transferase;IPR037171,NagB/RpiA transferase-like;IPR004164,Coenzyme A transferase active site;IPR012792,3-oxoacid CoA-transferase, subunit A;IPR004165,Coenzyme A transferase family I;IPR004163,Coenzyme A transferase binding site","COG1788,Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit;KOG3822,Succinyl-CoA:alpha-ketoacid-CoA transferase;COG2057,Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit","GO:0045471,biological_process,response to ethanol;GO:0009725,biological_process,response to hormone;GO:0014823,biological_process,response to activity;GO:0007507,biological_process,heart development;GO:0046952,biological_process,ketone body catabolic process;GO:0007584,biological_process,response to nutrient;GO:0042803,molecular_function,protein homodimerization activity;GO:0042594,biological_process,response to starvation;GO:0042182,biological_process,ketone catabolic process;GO:0016740,molecular_function,transferase activity;GO:0035774,biological_process,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0046950,biological_process,cellular ketone body metabolic process;GO:0008410,molecular_function,CoA-transferase activity;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0007420,biological_process,brain development;GO:0060612,biological_process,adipose tissue development;GO:0008260,molecular_function,3-oxoacid CoA-transferase activity;GO:0042493,biological_process,response to drug;GO:0005654,cellular_component,nucleoplasm","K01027,ko00280,Valine, leucine and isoleucine degradation;K01027,ko00650,Butanoate metabolism;K01027,ko00072,Synthesis and degradation of ketone bodies"]
["RP4-635E18.6",12.40463446,4.279186783,1.521430581,2.379330978,0.02192594,0.038134027,"ENSG00000230337","H2N947,Exosome component 10","-","PF08066,PMC2NT (NUC016) domain;PF01612,3'-5' exonuclease;PF00570,HRDC domain","IPR012588,Exosome-associated factor Rrp6, N-terminal;IPR012337,Ribonuclease H-like superfamily;IPR010997,HRDC-like superfamily;IPR002121,HRDC domain;IPR002562,3'-5' exonuclease domain","COG0349,Ribonuclease D;KOG2206,Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6)","GO:0008408,molecular_function,3'-5' exonuclease activity;GO:0071034,biological_process,CUT catabolic process;GO:0009048,biological_process,dosage compensation by inactivation of X chromosome;GO:0003676,molecular_function,nucleic acid binding;GO:0005634,cellular_component,nucleus;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0004532,molecular_function,exoribonuclease activity;GO:0000460,biological_process,maturation of 5.8S rRNA;GO:0005737,cellular_component,cytoplasm;GO:0003824,molecular_function,catalytic activity;GO:0005829,cellular_component,cytosol;GO:0006396,biological_process,RNA processing;GO:0000176,cellular_component,nuclear exosome (RNase complex);GO:0071028,biological_process,nuclear mRNA surveillance;GO:0071044,biological_process,histone mRNA catabolic process;GO:0000956,biological_process,nuclear-transcribed mRNA catabolic process;GO:0000166,molecular_function,nucleotide binding;GO:0032211,biological_process,negative regulation of telomere maintenance via telomerase;GO:0090503,biological_process,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0071048,biological_process,nuclear retention of unspliced pre-mRNA at the site of transcription;GO:0005730,cellular_component,nucleolus;GO:1904872,biological_process,regulation of telomerase RNA localization to Cajal body;GO:0044237,biological_process,cellular metabolic process;GO:0035327,cellular_component,transcriptionally active chromatin;GO:0071035,biological_process,nuclear polyadenylation-dependent rRNA catabolic process;GO:0000175,molecular_function,3'-5'-exoribonuclease activity;GO:0005622,cellular_component,intracellular;GO:0000178,cellular_component,exosome (RNase complex);GO:0006139,biological_process,nucleobase-containing compound metabolic process","-"]
["CPNE8",1.284064131,0.442959466,1.521430581,2.379330978,0.02192594,0.038134027,"ENSG00000139117","G1S8J3,Copine 8","-","PF07002,Copine;PF00168,C2 domain","-","-","-","-"]
["MERTK",1.414656185,0.488009386,1.521430581,2.379330978,0.02192594,0.038134027,"ENSG00000153208","B2RE75,cDNA, FLJ95000, highly similar to Homo sapiens c-mer proto-oncogene tyrosine kinase","-","PF13927,Immunoglobulin domain;PF07714,Protein tyrosine kinase;PF00041,ibronectin type III domain;PF00047,Immunoglobulin domain","IPR013783,Immunoglobulin-like fold;IPR003961,Fibronectin type III;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR013151,Immunoglobulin;IPR036116,Fibronectin type III superfamily;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR036179,Immunoglobulin-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR003599,Immunoglobulin subtype;IPR007110,Immunoglobulin-like domain;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;ENOG410IG6I,-","GO:0016301,molecular_function,kinase activity;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","-"]
["CDC27",11.44847418,3.985355501,1.521185721,5.744122483,{"v":1.56e-08,"d":"1.56E-08"},{"v":1.1e-07,"d":"1.10E-07"},"ENSG00000004897","G1QXR9,Cell division cycle 27","XP_003270750.1,cell division cycle protein 27 homolog isoform X1","PF00515,Tetratricopeptide repeat;PF12895,Anaphase-promoting complex, cyclosome, subunit 3;PF13181,Tetratricopeptide repeat","IPR001440,Tetratricopeptide repeat 1;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","COG0457,FOG: TPR repeat;KOG1126,DNA-binding cell division cycle control protein","GO:0019903,molecular_function,protein phosphatase binding;GO:0070979,biological_process,protein K11-linked ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0007091,biological_process,metaphase/anaphase transition of mitotic cell cycle;GO:0005876,cellular_component,spindle microtubule;GO:0005813,cellular_component,centrosome;GO:0005680,cellular_component,anaphase-promoting complex;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["LETM1",11.95424974,4.163856096,1.520582465,6.063983311,{"v":3.86e-09,"d":"3.86E-09"},{"v":3.11e-08,"d":"3.11E-08"},"ENSG00000168924","K7CEE6,Leucine zipper-EF-hand containing transmembrane protein 1","XP_016806627.1,LETM1 and EF-hand domain-containing protein 1, mitochondrial isoform X1","PF07766,LETM1-like protein","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR011685,LETM1-like;IPR033122,Letm1 ribosome-binding domain;IPR011992,EF-hand domain pair","ENOG410XRSP,-;KOG1043,Ca2+-binding transmembrane protein LETM1/MRS7","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0005739,cellular_component,mitochondrion;GO:0043022,molecular_function,ribosome binding;GO:0005509,molecular_function,calcium ion binding","K17800,ko04139,Regulation of mitophagy - yeast"]
["CTPS1",9.477537838,3.299430516,1.520501367,5.162357043,{"v":2.42e-07,"d":"2.42E-07"},{"v":1.3E-6,"d":"1.30E-06"},"ENSG00000171793","K6ZWB2,CTP synthase","XP_524681.3,-;XP_009453494.2,-;XP_009453492.2,-","PF00117,lutamine amidotransferase class-I;PF06418,CTP synthase N-terminus","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR017926,Glutamine amidotransferase;IPR017456,CTP synthase, N-terminal;IPR004468,CTP synthase;IPR029062,Class I glutamine amidotransferase-like;IPR033828,CTP synthase GATase domain","COG0504,CTP synthase (UTP-ammonia lyase);KOG2387,CTP synthase (UTP-ammonia lyase)","GO:0044210,biological_process,'de novo' CTP biosynthetic process;GO:0003883,molecular_function,CTP synthase activity;GO:0006221,biological_process,pyrimidine nucleotide biosynthetic process;GO:0006241,biological_process,CTP biosynthetic process;GO:0006541,biological_process,glutamine metabolic process;GO:0016874,molecular_function,ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","K01937,ko00240,Pyrimidine metabolism"]
["STAU1",64.4982124,22.48984564,1.519634233,7.484098446,{"v":2.65e-11,"d":"2.65E-11"},{"v":3.48e-10,"d":"3.48E-10"},"ENSG00000124214","Q59F99,Staufen isoform b variant","NP_001306064.1,-","PF16482,Staufen C-terminal domain;PF00035,ouble-stranded RNA binding motif","IPR032478,Staufen, C-terminal;IPR014720,Double-stranded RNA-binding domain","ENOG410XSCK,-;KOG3732,Staufen and related double-stranded-RNA-binding proteins","GO:0003723,molecular_function,RNA binding","-"]
["TRMT2A",6.890718321,2.397739063,1.519580534,4.268877601,{"v":2.24e-05,"d":"2.24E-05"},{"v":7.9e-05,"d":"7.90E-05"},"ENSG00000099899","F2Z2W7,tRNA","NP_001317968.1,tRNA (uracil-5-)-methyltransferase homolog A isoform c;XP_011528441.1,-","PF13649,Methyltransferase domain;PF13847,Methyltransferase domain;PF05958,tRNA (Uracil-5-)-methyltransferase","IPR034262,TRMT2A, RNA recognition motif;IPR010280,(Uracil-5)-methyltransferase family;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR025714,Methyltransferase domain","COG2265,SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase;KOG2187,tRNA uracil-5-methyltransferase and related tRNA-modifying enzymes","GO:0008173,molecular_function,RNA methyltransferase activity;GO:0001510,biological_process,RNA methylation;GO:0003676,molecular_function,nucleic acid binding;GO:0016740,molecular_function,transferase activity;GO:0003723,molecular_function,RNA binding;GO:0008168,molecular_function,methyltransferase activity;GO:0006396,biological_process,RNA processing;GO:0032259,biological_process,methylation","-"]
["FAM171A1",1.440971804,0.497087401,1.519117751,2.185329316,0.034844927,0.057057327,"ENSG00000148468","K7BFR3,Family with sequence similarity 171, member A1","XP_016818206.1,protein FAM171A1 isoform X1","PF10577,Uncharacterised protein family UPF0560","IPR018890,Uncharacterised protein family FAM171","ENOG410ZV9V,-;ENOG410IKM3,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["LLNLF-65H9.1",6.167795981,2.127684708,1.519117751,2.185329316,0.034844927,0.057057327,"ENSG00000272635","G3RBY9,Uncharacterized protein","-","PF08613,Cyclin","-","-","-","-"]
["KPNA5",0.499171716,0.172197659,1.519117751,2.185329316,0.034844927,0.057057327,"ENSG00000196911","G3R8B6,Importin subunit alpha","XP_004044631.1,-","PF01749,Importin beta binding domain;PF16186,Atypical Arm repeat;PF00514,Armadillo/beta-catenin-like repeat","IPR002652,Importin-alpha, importin-beta-binding domain;IPR024931,Importin subunit alpha;IPR036975,Importin-alpha, importin-beta-binding domain superfamily;IPR032413,Atypical Arm repeat;IPR000225,Armadillo;IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical","-","GO:0061608,molecular_function,nuclear import signal receptor activity;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0006606,biological_process,protein import into nucleus;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0008565,molecular_function,protein transporter activity","-"]
["RNF217-AS1",1.264487128,0.436206051,1.519117751,2.185329316,0.034844927,0.057057327,"ENSG00000236548","W5NPE7,Uncharacterized protein","-","PF03372,ndonuclease/Exonuclease/phosphatase family;PF00078,Reverse transcriptase (RNA-dependent DNA polymerase)","IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR005135,Endonuclease/exonuclease/phosphatase;IPR000477,Reverse transcriptase domain","-","-","-"]
["LINC00221",8.541178265,2.972967097,1.519011913,4.220030301,{"v":1.81e-05,"d":"1.81E-05"},{"v":6.5e-05,"d":"6.50E-05"},"ENSG00000270816","H2NMJ2,Uncharacterized protein","-","-","-","-","-","-"]
["EDC3",5.165211861,1.797878985,1.519011913,4.220030301,{"v":1.81e-05,"d":"1.81E-05"},{"v":6.5e-05,"d":"6.50E-05"},"ENSG00000179151","K7C295,Enhancer of mRNA decapping 3 homolog","XP_016782681.1,-;XP_016782682.1,-","PF16598,Linker region of enhancer of mRNA-decapping protein 3;PF03853,YjeF-related protein N-terminus;PF12701,Scd6-like Sm domain;PF09532,domain","IPR004443,YjeF N-terminal domain;IPR025762,DFDF domain;IPR034107,Lsm16, N-terminal;IPR025609,Lsm14-like, N-terminal;IPR019050,FDF domain;IPR036652,YjeF N-terminal domain superfamily","COG0062,Uncharacterized conserved protein;KOG2585,Uncharacterized conserved protein","GO:1990174,molecular_function,phosphodiesterase decapping endonuclease activity;GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0031087,biological_process,deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0042802,molecular_function,identical protein binding;GO:0003729,molecular_function,mRNA binding","K12615,ko03018,RNA degradation"]
["EEF2K",5.388746439,1.879366393,1.517561057,4.909358946,{"v":8.16E-7,"d":"8.16E-07"},{"v":3.92e-06,"d":"3.92E-06"},"ENSG00000103319","H2NQD5,Eukaryotic elongation factor 2 kinase","XP_002826262.1,eukaryotic elongation factor 2 kinase","PF08238,Sel1 repeat;PF02816,Alpha-kinase family","IPR004166,MHCK/EF2 kinase;IPR006597,Sel1-like repeat;IPR011009,Protein kinase-like domain superfamily;IPR017400,Eukaryotic elongation factor 2 kinase;IPR011990,Tetratricopeptide-like helical domain superfamily","ENOG410YE3S,-;ENOG410IFRY,-","GO:0016301,molecular_function,kinase activity;GO:0004686,molecular_function,elongation factor-2 kinase activity;GO:0016310,biological_process,phosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0005516,molecular_function,calmodulin binding;GO:0016740,molecular_function,transferase activity;GO:0031952,biological_process,regulation of protein autophosphorylation;GO:0006468,biological_process,protein phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005509,molecular_function,calcium ion binding;GO:0046777,biological_process,protein autophosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","K08292,ko04152,AMPK signaling pathway;K08292,ko04921,Oxytocin signaling pathway"]
["RP5-864K19.6",7.231176371,2.519712743,1.517032508,4.062615461,{"v":4.63e-05,"d":"4.63E-05"},0.000151943,"ENSG00000274944","C9IYK1,Gap junction protein","-","PF00029,Connexin","IPR013092,Connexin, N-terminal;IPR038359,Connexin, N-terminal domain superfamily;IPR017990,Connexin, conserved site;IPR000500,Connexin;IPR019570,Gap junction protein, cysteine-rich domain","ENOG410IGQJ,-;ENOG4110KSA,-","GO:0030054,cellular_component,cell junction;GO:0005921,cellular_component,gap junction;GO:0005922,cellular_component,connexin complex;GO:0007154,biological_process,cell communication;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["RAB5B",20.36505496,7.112306109,1.517017049,6.515171807,{"v":6.39e-10,"d":"6.39E-10"},{"v":6.17E-9,"d":"6.17E-09"},"ENSG00000111540","A0A091D0Q5,Ras-related protein Rab-5B","XP_010643066.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding","-"]
["SENP6",6.74058937,2.353986551,1.516566942,5.723544549,{"v":1.91e-08,"d":"1.91E-08"},{"v":1.32e-07,"d":"1.32E-07"},"ENSG00000112701","G3QUC6,SUMO1/sentrin specific peptidase 6","-","PF02902,Ulp1 protease family, C-terminal catalytic domain","IPR003653,Ulp1 protease family, C-terminal catalytic domain","-","GO:0006508,biological_process,proteolysis;GO:0008234,molecular_function,cysteine-type peptidase activity","-"]
["DAZAP1",17.62691873,6.160827736,1.516014596,6.786546095,{"v":2.42e-10,"d":"2.42E-10"},{"v":2.54e-09,"d":"2.54E-09"},"ENSG00000071626","A0A0A0MUA7,DAZ associated protein 1","XP_003914631.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034134,DAZ-associated protein 1, RNA recognition motif 1;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR035979,RNA-binding domain superfamily;IPR034131,DAZ-associated protein 1, RNA recognition motif 2;IPR000504,RNA recognition motif domain","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["TAS2R14",2.020937407,0.697156266,1.515892643,1.960330199,0.045280597,0.071892328,"ENSG00000212127","J7M477,Taste receptor type 2","-","PF05296,Taste receptor protein (TAS2R)","-","-","-","-"]
["SERAC1",0.535242072,0.184640733,1.515892643,1.960330199,0.045280597,0.071892328,"ENSG00000122335","K7BCH1,Serine active site containing 1","XP_016812027.1,-;XP_016812025.1,-","-","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR029058,Alpha/Beta hydrolase fold","ENOG410YIPC,-;KOG2029,Uncharacterized conserved protein","-","-"]
["CLDN3",3.72778878,1.285963285,1.515892643,1.960330199,0.045280597,0.071892328,"ENSG00000165215","G3S2W1,Claudin","XP_004045615.1,-","PF00822,PMP-22/EMP/MP20/Claudin family","IPR006187,Claudin;IPR017974,Claudin, conserved site;IPR003549,Claudin-3;IPR004031,PMP-22/EMP/MP20/Claudin superfamily","-","GO:0070830,biological_process,bicellular tight junction assembly;GO:0030054,cellular_component,cell junction;GO:0016338,biological_process,calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0005923,cellular_component,bicellular tight junction;GO:0051260,biological_process,protein homooligomerization;GO:0042802,molecular_function,identical protein binding;GO:0016328,cellular_component,lateral plasma membrane;GO:0016020,cellular_component,membrane;GO:0051291,biological_process,protein heterooligomerization;GO:0005886,cellular_component,plasma membrane;GO:0003382,biological_process,epithelial cell morphogenesis;GO:0005198,molecular_function,structural molecule activity;GO:0001666,biological_process,response to hypoxia;GO:0016327,cellular_component,apicolateral plasma membrane;GO:0016021,cellular_component,integral component of membrane","K06087,ko04514,Cell adhesion molecules (CAMs);K06087,ko04670,Leukocyte transendothelial migration;K06087,ko04530,Tight junction;K06087,ko05160,Hepatitis C"]
["CTD-2555O16.4",11.55554718,4.030085153,1.515425342,3.947144968,{"v":6.13e-05,"d":"6.13E-05"},1.95086E-4,"ENSG00000272909","Q9P147,PRO2822","-","-","-","-","-","-"]
["PPP2CB",15.98491678,5.586821362,1.515332506,5.633508996,{"v":2.88E-8,"d":"2.88E-08"},{"v":1.91E-7,"d":"1.91E-07"},"ENSG00000104695","A0A250YF46,Serine/threonine-protein phosphatase","XP_020028211.1,-","-","IPR029052,Metallo-dependent phosphatase-like;IPR004843,Calcineurin-like phosphoesterase domain, ApaH type;IPR006186,Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase","-","GO:0006470,biological_process,protein dephosphorylation;GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity","K04382,ko04390,Hippo signaling pathway;K04382,ko04261,Adrenergic signaling in cardiomyocytes;K04382,ko03015,mRNA surveillance pathway;K04382,ko04530,Tight junction;K04382,ko04391,Hippo signaling pathway - fly;K04382,ko04114,Oocyte meiosis;K04382,ko04152,AMPK signaling pathway;K04382,ko04350,TGF-beta signaling pathway;K04382,ko05160,Hepatitis C;K04382,ko05142,Chagas disease (American trypanosomiasis);K04382,ko04113,Meiosis - yeast;K04382,ko04730,Long-term depression;K04382,ko04728,Dopaminergic synapse;K04382,ko04013,MAPK signaling pathway - fly;K04382,ko04071,Sphingolipid signaling pathway;K04382,ko04111,Cell cycle - yeast;K04382,ko04151,PI3K-Akt signaling pathway"]
["TMEM87B",3.930561766,1.371498438,1.514511903,3.885712877,1.02124E-4,0.000308462,"ENSG00000153214","K7BPI1,Transmembrane protein 87B","XP_016804739.1,transmembrane protein 87B isoform X1","PF06814,Lung seven transmembrane receptor","IPR009637,Lung seven transmembrane receptor-like","ENOG410XS1Q,-;KOG2568,Predicted membrane protein","GO:0005829,cellular_component,cytosol;GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MICU1",17.78172695,6.21930096,1.514222478,5.55719451,{"v":4.07E-8,"d":"4.07E-08"},{"v":2.61e-07,"d":"2.61E-07"},"ENSG00000107745","A0A0U1RRK1,Calcium uptake protein 1, mitochondrial","-","PF13833,-hand domain pair;PF13202,hand","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR011992,EF-hand domain pair","-","GO:0005739,cellular_component,mitochondrion;GO:0005509,molecular_function,calcium ion binding","-"]
["STAT3",9.242944829,3.23498862,1.513460563,5.805196197,{"v":1.47e-08,"d":"1.47E-08"},{"v":1.04E-7,"d":"1.04E-07"},"ENSG00000168610","H2QD20,Signal transducer and activator of transcription","-","PF02865,STAT protein, protein interaction domain;PF01017,STAT protein, all-alpha domain;PF00017,SH2 domain;PF02864,STAT protein, DNA binding domain","IPR035855,STAT3, SH2 domain;IPR036860,SH2 domain superfamily;IPR015988,STAT transcription factor, coiled coil;IPR036535,STAT transcription factor, N-terminal domain superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR013801,STAT transcription factor, DNA-binding;IPR000980,SH2 domain;IPR012345,STAT transcription factor, DNA-binding, N-terminal;IPR013800,STAT transcription factor, all-alpha domain;IPR013799,STAT transcription factor, protein interaction;IPR001217,Transcription factor STAT","KOG3667,STAT protein;ENOG410XPN8,-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0004871,molecular_function,signal transducer activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction","-"]
["DMTF1",3.580688184,1.25261591,1.51256107,4.563512935,{"v":5.27e-06,"d":"5.27E-06"},{"v":2.13e-05,"d":"2.13E-05"},"ENSG00000135164","K7C0Q0,Cyclin D binding myb-like transcription factor 1","-","PF00249,Myb-like DNA-binding domain","IPR017877,Myb-like domain;IPR009057,Homeobox-like domain superfamily;IPR001005,SANT/Myb domain;IPR017930,Myb domain","KOG0051,RNA polymerase I termination factor, Myb superfamily;COG5147,Myb superfamily proteins, including transcription factors and mRNA splicing factors","GO:0003677,molecular_function,DNA binding","-"]
["DCAF10",2.209061644,0.771699117,1.51241023,3.754305902,0.000228795,0.000638793,"ENSG00000122741","H2QXA6,DDB1 and CUL4 associated factor 10","XP_001170070.1,DDB1- and CUL4-associated factor 10 isoform X1","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR019775,WD40 repeat, conserved site;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","ENOG410ZF1A,-;ENOG410ISIZ,-","GO:0080008,cellular_component,Cul4-RING E3 ubiquitin ligase complex","-"]
["ARRB2",17.76062843,6.220509136,1.512392659,5.737661057,{"v":1.76e-08,"d":"1.76E-08"},{"v":1.22e-07,"d":"1.22E-07"},"ENSG00000141480","G3QRU2,Arrestin beta 2","XP_004058369.1,-","PF00339,Arrestin (or S-antigen), N-terminal domain;PF02752,Arrestin (or S-antigen), C-terminal domain","IPR011022,Arrestin C-terminal-like domain;IPR014753,Arrestin, N-terminal;IPR011021,Arrestin-like, N-terminal;IPR014752,Arrestin, C-terminal;IPR000698,Arrestin;IPR017864,Arrestin, conserved site;IPR014756,Immunoglobulin E-set","-","GO:0007165,biological_process,signal transduction","-"]
["AMMECR1",4.883311766,1.709723317,1.511206238,4.483088576,{"v":7.78e-06,"d":"7.78E-06"},{"v":3.03e-05,"d":"3.03E-05"},"ENSG00000101935","K7BQ20,Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1","XP_016798429.1,-","PF01871,AMMECR1","IPR002733,AMMECR1 domain;IPR023473,AMMECR1;IPR027485,AMMECR1, N-terminal;IPR036071,AMMECR1 domain superfamily","COG2078,Uncharacterized conserved protein;KOG3274,Uncharacterized conserved protein, AMMECR1","GO:0005634,cellular_component,nucleus","-"]
["MAP2K1",11.93933691,4.184050376,1.510702743,4.963995454,{"v":6.04e-07,"d":"6.04E-07"},{"v":2.99e-06,"d":"2.99E-06"},"ENSG00000169032","H2Q9N2,Dual-specificity mitogen-activated protein kinase kinase 1","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0581,Mitogen-activated protein kinase kinase (MAP2K);ENOG410XQ5A,-","GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["NUP155",4.860821776,1.70343825,1.510702743,4.963995454,{"v":6.04e-07,"d":"6.04E-07"},{"v":2.99e-06,"d":"2.99E-06"},"ENSG00000113569","A0A024R071,Nucleoporin 155kDa, isoform CRA_a","NP_705618.1,nuclear pore complex protein Nup155 isoform 1","PF08801,Nup133 N terminal like;PF03177,Non-repetitive/WGA-negative nucleoporin C-terminal","IPR004870,Nucleoporin, Nup155-like;IPR014908,Nucleoporin, Nup133/Nup155-like, N-terminal;IPR007187,Nucleoporin, Nup133/Nup155-like, C-terminal","COG5308,Nuclear pore complex subunit;KOG1900,Nuclear pore complex, Nup155 component (D Nup154, sc Nup157/Nup170)","GO:0005643,cellular_component,nuclear pore;GO:0006606,biological_process,protein import into nucleus;GO:0086014,biological_process,atrial cardiac muscle cell action potential;GO:0006913,biological_process,nucleocytoplasmic transport;GO:0031965,cellular_component,nuclear membrane;GO:0006406,biological_process,mRNA export from nucleus;GO:0017056,molecular_function,structural constituent of nuclear pore","K14312,ko03013,RNA transport"]
["COL4A1",3.770129322,1.320578125,1.510466898,4.441119596,{"v":7.72e-06,"d":"7.72E-06"},{"v":3.01E-5,"d":"3.01E-05"},"ENSG00000187498","K7C8P4,Collagen, type IV, alpha 1","XP_016781016.1,-","PF01391,Collagen triple helix repeat (20 copies);PF01413,C-terminal tandem repeated domain in type 4 procollagen","IPR008160,Collagen triple helix repeat;IPR016187,C-type lectin fold;IPR036954,Collagen IV, non-collagenous domain superfamily;IPR001442,Collagen IV, non-collagenous","-","GO:0005604,cellular_component,basement membrane;GO:0005578,,;GO:0005581,cellular_component,collagen trimer;GO:0001569,biological_process,branching involved in blood vessel morphogenesis;GO:0005201,molecular_function,extracellular matrix structural constituent;GO:0007528,biological_process,neuromuscular junction development;GO:0031012,cellular_component,extracellular matrix;GO:0005587,cellular_component,collagen type IV trimer;GO:0048407,molecular_function,platelet-derived growth factor binding;GO:0071230,biological_process,cellular response to amino acid stimulus;GO:0071711,biological_process,basement membrane organization;GO:0061333,biological_process,renal tubule morphogenesis;GO:0007420,biological_process,brain development;GO:0038063,biological_process,collagen-activated tyrosine kinase receptor signaling pathway;GO:0048514,biological_process,blood vessel morphogenesis;GO:0061304,biological_process,retinal blood vessel morphogenesis;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space","K06237,ko04974,Protein digestion and absorption;K06237,ko04510,Focal adhesion;K06237,ko04933,AGE-RAGE signaling pathway in diabetic complications;K06237,ko05200,Pathways in cancer;K06237,ko05222,Small cell lung cancer;K06237,ko04151,PI3K-Akt signaling pathway;K06237,ko04512,ECM-receptor interaction;K06237,ko05146,Amoebiasis"]
["ANKRD50",14.23032711,4.99282484,1.510306844,6.417462362,{"v":1.06e-09,"d":"1.06E-09"},{"v":9.68e-09,"d":"9.68E-09"},"ENSG00000151458","H2QQ51,Ankyrin repeat domain 50","XP_517429.1,ankyrin repeat domain-containing protein 50","PF12796,Ankyrin repeats (3 copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","GO:1990126,biological_process,retrograde transport, endosome to plasma membrane;GO:0005622,cellular_component,intracellular","-"]
["EVPL",14.67130591,5.148373704,1.509975465,6.23594992,{"v":1.98e-09,"d":"1.98E-09"},{"v":1.7E-8,"d":"1.70E-08"},"ENSG00000167880","K7EKI0,Envoplakin","NP_001307676.1,envoplakin isoform 1","PF00681,Plectin repeat","IPR035915,Plakin repeat superfamily;IPR030460,Envoplakin;IPR018159,Spectrin/alpha-actinin;IPR001101,Plectin repeat","ENOG410XRFQ,-;ENOG410IQBQ,-","GO:0008544,biological_process,epidermis development;GO:0001533,cellular_component,cornified envelope;GO:0019215,molecular_function,intermediate filament binding;GO:0005856,cellular_component,cytoskeleton;GO:0045111,cellular_component,intermediate filament cytoskeleton;GO:0005198,molecular_function,structural molecule activity;GO:0005829,cellular_component,cytosol","-"]
["RP11-574K11.31",2.897846393,1.013740463,1.50984007,3.609562379,0.000329839,0.000889428,"ENSG00000272916","S4R438,Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2","NP_001317036.1,bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 2","PF12062,heparan sulfate-N-deacetylase;PF00685,Sulfotransferase domain","IPR037359,Heparan sulfate sulfotransferase;IPR000863,Sulfotransferase domain;IPR021930,Heparan sulphate-N-deacetylase;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410XQN4,-;KOG3703,Heparan sulfate N-deacetylase/N-sulfotransferase","GO:0008146,molecular_function,sulfotransferase activity;GO:0015016,molecular_function,[heparan sulfate]-glucosamine N-sulfotransferase activity;GO:0016787,molecular_function,hydrolase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CDC25A",4.095134883,1.432582466,1.50984007,3.609562379,0.000329839,0.000889428,"ENSG00000164045","A0A024R2S4,Cell division cycle 25A, isoform CRA_a","NP_001780.2,M-phase inducer phosphatase 1 isoform a;XP_011532618.1,-","PF00581,Rhodanese-like domain;PF06617,M-phase inducer phosphatase","IPR001763,Rhodanese-like domain;IPR036873,Rhodanese-like domain superfamily;IPR000751,M-phase inducer phosphatase","KOG3772,M-phase inducer phosphatase;COG5105,Mitotic inducer, protein phosphatase","GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0006470,biological_process,protein dephosphorylation;GO:0051301,biological_process,cell division;GO:0005622,cellular_component,intracellular;GO:1902751,biological_process,positive regulation of cell cycle G2/M phase transition;GO:0005634,cellular_component,nucleus","K06645,ko05206,MicroRNAs in cancer;K06645,ko04914,Progesterone-mediated oocyte maturation;K06645,ko04110,Cell cycle"]
["SCAF8",14.99018615,5.260788755,1.509550389,5.818539732,{"v":1.36e-08,"d":"1.36E-08"},{"v":9.72e-08,"d":"9.72E-08"},"ENSG00000213079","A0A0A0MT33,Protein SCAF8","NP_001273117.1,protein SCAF8 isoform a","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF04818,RNA polymerase II-binding domain.","IPR006903,RNA polymerase II-binding domain;IPR008942,ENTH/VHS;IPR034370,SCAF8, RNA recognition motif;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR006569,CID domain","ENOG410XT48,-;KOG0132,RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005654,cellular_component,nucleoplasm","-"]
["LA16c-306E5.3",54.76396545,19.20144952,1.508844274,4.353305977,{"v":1.45E-5,"d":"1.45E-05"},{"v":5.3e-05,"d":"5.30E-05"},"ENSG00000263212","H9FRN0,Clusterin-associated protein 1 isoform 1","-","PF10234,Clusterin-associated protein-1","IPR019366,Clusterin-associated protein-1","ENOG410XRVS,-;KOG3647,Predicted coiled-coil protein","-","-"]
["CENPL",3.237653589,1.133552822,1.508327465,3.531279875,0.000448896,1.170272E-3,"ENSG00000120334","H2QXJ0,Uncharacterized protein","-","PF13092,Kinetochore complex Sim4 subunit Fta1","IPR025204,Centromere subunit  L","ENOG410XZDF,-;ENOG410IIZ1,-","-","-"]
["GGT6",5.033163472,1.762188727,1.508327465,3.531279875,0.000448896,1.170272E-3,"ENSG00000167741","J3KPJ0,Glutathione hydrolase 6","NP_001275631.1,glutathione hydrolase 6 isoform c","PF01019,amma-glutamyltranspeptidase","IPR000101,Gamma-glutamyltranspeptidase;IPR029055,Nucleophile aminohydrolases, N-terminal","KOG2410,Gamma-glutamyltransferase;COG0405,Gamma-glutamyltransferase","GO:0006508,biological_process,proteolysis;GO:0036374,molecular_function,glutathione hydrolase activity;GO:0006751,biological_process,glutathione catabolic process","-"]
["TUSC2",11.64600879,4.085579116,1.507951337,4.307295572,{"v":1.8E-5,"d":"1.80E-05"},{"v":6.45e-05,"d":"6.45E-05"},"ENSG00000114383","F7DQ08,Tumor suppressor candidate 2","NP_001248595.1,tumor suppressor candidate 2","PF15000,Tumour suppressor candidate 2","IPR029393,Tumour suppressor candidate 2","ENOG410IYM4,-;ENOG4111PVZ,-","-","-"]
["RCC1L",6.451491078,2.26459483,1.506996428,4.259758452,{"v":2.79e-05,"d":"2.79E-05"},{"v":9.6e-05,"d":"9.60E-05"},"ENSG00000274523","H2QUR9,Williams-Beuren syndrome chromosome region 16","XP_001153683.1,Williams-Beuren syndrome chromosomal region 16 protein isoform X3;XP_016800753.1,-","PF00415,Regulator of chromosome condensation (RCC1) repeat;PF13540,Regulator of chromosome condensation (RCC1) repeat","IPR000408,Regulator of chromosome condensation, RCC1;IPR009091,Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II","KOG1426,FOG: RCC1 domain;COG5184,Alpha-tubulin suppressor and related RCC1 domain-containing proteins","-","-"]
["PHB2",77.53800662,27.27250763,1.50698411,7.043553636,{"v":1.24e-10,"d":"1.24E-10"},{"v":1.38E-9,"d":"1.38E-09"},"ENSG00000215021","A0A250YF22,Prohibitin-2","XP_020013811.1,-","-","IPR000163,Prohibitin;IPR001107,Band 7 domain;IPR036013,Band 7/SPFH domain superfamily","-","GO:0016020,cellular_component,membrane","-"]
["GORAB",3.965011702,1.389508381,1.506625122,3.448444656,0.000616405,0.001558738,"ENSG00000120370","K7DKA5,Golgin, RAB6-interacting","-","PF04949,Transcriptional activator","IPR007033,RAB6-interacting golgin","ENOG4111VTM,-;ENOG410IJC7,-","-","-"]
["NUBPL",1.971013064,0.69072663,1.506625122,3.448444656,0.000616405,0.001558738,"ENSG00000151413","X5D2R5,Nucleotide binding protein-like isoform A","NP_079428.2,iron-sulfur protein NUBPL isoform 1 precursor","PF10609,NUBPL iron-transfer P-loop NTPase","IPR000808,Mrp, conserved site;IPR033756,Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35;IPR019591,Mrp/NBP35 ATP-binding protein;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG3022,Predicted ATPase, nucleotide-binding;COG0489,ATPases involved in chromosome partitioning","GO:0005886,cellular_component,plasma membrane;GO:0005524,molecular_function,ATP binding;GO:0005739,cellular_component,mitochondrion","-"]
["MYO10",6.870579295,2.417054705,1.506228525,6.039684035,{"v":6.22e-09,"d":"6.22E-09"},{"v":4.8E-8,"d":"4.80E-08"},"ENSG00000145555","A0A0A0MQX1,Unconventional myosin-X","-","PF16735,Unconventional myosin-X coiled coil domain;PF00063,Myosin head (motor domain);PF00612,IQ calmodulin-binding motif;PF00784,MyTH4 domain;PF00788,Ras association (RalGDS/AF-6) domain;PF00373,RM central domain;PF00169,PH domain","IPR019748,FERM central domain;IPR038185,MyTH4 domain superfamily;IPR001609,Myosin head, motor domain;IPR031971,Unconventional myosin-X, coiled coil domain;IPR000159,Ras-associating (RA) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR000299,FERM domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR036124,Class X myosin, motor domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR000048,IQ motif, EF-hand binding site;IPR036961,Kinesin motor domain superfamily;IPR000857,MyTH4 domain","KOG4229,Myosin VII, myosin IXB and related myosins;COG5022,Myosin heavy chain","GO:0005730,cellular_component,nucleolus;GO:0003774,molecular_function,motor activity;GO:0005524,molecular_function,ATP binding;GO:0005856,cellular_component,cytoskeleton;GO:0005886,cellular_component,plasma membrane;GO:0003779,molecular_function,actin binding;GO:0008017,molecular_function,microtubule binding;GO:0005829,cellular_component,cytosol;GO:0007018,biological_process,microtubule-based movement;GO:0016459,cellular_component,myosin complex;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity;GO:0007165,biological_process,signal transduction","-"]
["APLP2",115.0491376,40.50168205,1.506089825,9.181107703,{"v":2.07e-12,"d":"2.07E-12"},{"v":3.45e-11,"d":"3.45E-11"},"ENSG00000084234","H2NFW1,Amyloid beta precursor like protein 2","XP_002822747.1,amyloid-like protein 2 isoform X1","PF00014,Kunitz/Bovine pancreatic trypsin inhibitor domain;PF12924,Copper-binding of amyloid precursor, CuBD;PF10515,beta-amyloid precursor protein C-terminus;PF02177,Amyloid A4 N-terminal heparin-binding;PF12925,2 domain of amyloid precursor protein","IPR036454,Amyloidogenic glycoprotein, heparin-binding domain superfamily;IPR011993,PH-like domain superfamily;IPR011178,Amyloidogenic glycoprotein, copper-binding;IPR019744,Amyloidogenic glycoprotein, extracellular domain conserved site;IPR019543,Beta-amyloid precursor protein C-terminal;IPR020901,Proteinase inhibitor I2, Kunitz, conserved site;IPR036669,Amyloidogenic glycoprotein, copper-binding domain superfamily;IPR036880,Pancreatic trypsin inhibitor Kunitz domain superfamily;IPR036176,E2 domain superfamily;IPR019745,Amyloidogenic glycoprotein, intracellular domain, conserved site;IPR002223,Pancreatic trypsin inhibitor Kunitz domain;IPR008155,Amyloidogenic glycoprotein;IPR024329,Amyloidogenic glycoprotein, E2 domain;IPR008154,Amyloidogenic glycoprotein, extracellular;IPR015849,Amyloidogenic glycoprotein, heparin-binding","KOG3540,Beta amyloid precursor protein;ENOG410ZW2A,-","GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0046914,molecular_function,transition metal ion binding;GO:0004867,molecular_function,serine-type endopeptidase inhibitor activity;GO:0008201,molecular_function,heparin binding;GO:0016020,cellular_component,membrane;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","-"]
["MLX",19.45846225,6.847158162,1.50571771,5.831761171,{"v":1.25e-08,"d":"1.25E-08"},{"v":9.05e-08,"d":"9.05E-08"},"ENSG00000108788","G3R5L7,MLX, MAX dimerization protein","XP_004041660.2,max-like protein X isoform X1","PF00010,Helix-loop-helix DNA-binding domain","IPR032647,Max-like protein X;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0046983,molecular_function,protein dimerization activity;GO:0008134,molecular_function,transcription factor binding","-"]
["CBR1",19.38450166,6.820749265,1.504978189,5.044883643,{"v":5.59e-07,"d":"5.59E-07"},{"v":2.79E-6,"d":"2.79E-06"},"ENSG00000159228","G3QKD3,Carbonyl reductase 1","XP_004062803.1,-","PF08659,KR domain;PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily;IPR020904,Short-chain dehydrogenase/reductase, conserved site;IPR002347,Short-chain dehydrogenase/reductase SDR","-","GO:0042373,biological_process,vitamin K metabolic process;GO:0030855,biological_process,epithelial cell differentiation;GO:0004090,molecular_function,carbonyl reductase (NADPH) activity;GO:0017144,biological_process,drug metabolic process;GO:0016491,molecular_function,oxidoreductase activity;GO:0016655,molecular_function,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0055114,biological_process,oxidation-reduction process","K00079,ko00980,Metabolism of xenobiotics by cytochrome P450;K00079,ko05204,Chemical carcinogenesis;K00079,ko00590,Arachidonic acid metabolism"]
["NREP",1.500497866,0.526395167,1.50469495,3.36049046,0.001129198,0.002700977,"ENSG00000134986","G3QMC4,Neuronal regeneration related protein","-","PF11092,Neuronal protein 3.1 (p311)","IPR024417,Neuronal protein 3.1","-","-","-"]
["NGFR",13.90429284,4.895212914,1.504504864,5.319386787,{"v":1.42E-7,"d":"1.42E-07"},{"v":8.08e-07,"d":"8.08E-07"},"ENSG00000064300","K7CYQ2,Nerve growth factor receptor","-","PF00531,eath domain;PF00020,TNFR/NGFR cysteine-rich region","-","-","-","-"]
["HIPK1",6.115622276,2.153822214,1.503992532,5.296085593,{"v":1.6E-7,"d":"1.60E-07"},{"v":8.98e-07,"d":"8.98E-07"},"ENSG00000163349","K7AWU8,Homeodomain interacting protein kinase 1","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XPET,-;KOG0667,Dual-specificity tyrosine-phosphorylation regulated kinase","GO:0016301,molecular_function,kinase activity;GO:0003677,molecular_function,DNA binding;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0016310,biological_process,phosphorylation","-"]
["TRMT10B",4.556981155,1.600589055,1.50248793,3.266738005,0.000945626,2.289793E-3,"ENSG00000165275","H2QXA4,RNA","-","PF01746,tRNA (Guanine-1)-methyltransferase","IPR016009,tRNA methyltransferase TRMD/TRM10-type domain;IPR007356,tRNA (guanine-N1-)-methyltransferase, eukaryotic;IPR038459,tRNA methyltransferase TRM10-type domain superfamily;IPR028564,tRNA methyltransferase TRM10-type domain","ENOG4111JE4,-;KOG2967,Uncharacterized conserved protein","-","-"]
["GFPT1",11.73105613,4.139217894,1.50202766,6.155791429,{"v":3.61e-09,"d":"3.61E-09"},{"v":2.94e-08,"d":"2.94E-08"},"ENSG00000198380","G3QR66,Glutamine--fructose-6-phosphate transaminase 1","XP_004029406.1,-","PF13522,lutamine amidotransferase domain;PF01380,SIS domain","IPR035490,GlmS/FrlB, SIS domain 2;IPR017932,Glutamine amidotransferase type 2 domain;IPR001347,Sugar isomerase (SIS);IPR005855,Glucosamine-fructose-6-phosphate aminotransferase, isomerising;IPR035466,GlmS/AgaS, SIS domain 1;IPR029055,Nucleophile aminohydrolases, N-terminal","-","GO:0097367,molecular_function,carbohydrate derivative binding;GO:0032922,biological_process,circadian regulation of gene expression;GO:1901135,biological_process,carbohydrate derivative metabolic process;GO:0004360,molecular_function,glutamine-fructose-6-phosphate transaminase (isomerizing) activity;GO:1901137,biological_process,carbohydrate derivative biosynthetic process","-"]
["ACO2",15.16078136,5.351593015,1.500819704,5.404911104,{"v":1.07e-07,"d":"1.07E-07"},{"v":6.23e-07,"d":"6.23E-07"},"ENSG00000100412","A2A274,Aconitate hydratase, mitochondrial","-","PF00694,Aconitase C-terminal domain;PF00330,Aconitase family (aconitate hydratase)","IPR015928,Aconitase/3-isopropylmalate dehydratase, swivel;IPR015931,Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3;IPR001030,Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain;IPR015932,Aconitase, domain 2;IPR036008,Aconitase, iron-sulfur domain;IPR018136,Aconitase family, 4Fe-4S cluster binding site;IPR000573,Aconitase A/isopropylmalate dehydratase small subunit, swivel domain","COG1048,Aconitase A;KOG0453,Aconitase/homoaconitase (aconitase superfamily)","GO:0008152,biological_process,metabolic process","-"]
["KIAA0100",18.97624117,6.70583553,1.500186941,6.901419666,{"v":2.52e-10,"d":"2.52E-10"},{"v":2.63e-09,"d":"2.63E-09"},"ENSG00000007202","G3RKK6,KIAA0100","XP_004042048.1,protein KIAA0100 homolog isoform X1","PF10344,Mitochondrial protein from FMP27;PF10351,olgi-body localisation protein domain;PF10347,RNA pol II promoter Fmp27 protein domain","IPR019439,FMP27, N-terminal;IPR019441,FMP27, GFWDK domain;IPR019443,FMP27,  C-terminal","-","-","-"]
["SIAH1",1.800812998,0.633401455,1.499939896,3.166362735,1.801679E-3,4.117356E-3,"ENSG00000196470","F6WEY4,E3 ubiquitin-protein ligase","NP_001247767.1,-","PF03145,Seven in absentia protein family","IPR018121,Seven-in-absentia protein, TRAF-like domain;IPR008974,TRAF-like;IPR004162,E3 ubiquitin-protein ligase SIN-like;IPR013010,Zinc finger, SIAH-type;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG3002,Zn finger protein;ENOG410XVP0,-","GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0008022,molecular_function,protein C-terminus binding;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0030877,cellular_component,beta-catenin destruction complex;GO:0016567,biological_process,protein ubiquitination;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0030163,biological_process,protein catabolic process;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0007275,biological_process,multicellular organism development;GO:2001244,biological_process,positive regulation of intrinsic apoptotic signaling pathway;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0016874,molecular_function,ligase activity","K04506,ko04115,p53 signaling pathway;K04506,ko04013,MAPK signaling pathway - fly;K04506,ko04120,Ubiquitin mediated proteolysis;K04506,ko04310,Wnt signaling pathway"]
["BMT2",2.926647513,1.029392167,1.499939896,3.166362735,1.801679E-3,4.117356E-3,"ENSG00000164603","K7CX06,Probable methyltransferase BMT2 homolog","XP_009452493.2,-","PF11968,25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2","IPR021867,S-adenosylmethionine-dependent methyltransferase Bmt2-like;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase","ENOG410IH2N,-;ENOG410XT5Y,-","GO:1904047,molecular_function,S-adenosyl-L-methionine binding;GO:0140007,cellular_component,KICSTOR complex;GO:0016740,molecular_function,transferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:1904262,biological_process,negative regulation of TORC1 signaling;GO:1990130,cellular_component,GATOR1 complex;GO:0034198,biological_process,cellular response to amino acid starvation","-"]
["APPBP2",2.163974592,0.763088218,1.499509292,3.935680404,{"v":7.83e-05,"d":"7.83E-05"},0.000242536,"ENSG00000062725","A0A024QZ47,Amyloid beta protein","NP_006371.2,amyloid protein-binding protein 2 isoform 1","PF13374,Tetratricopeptide repeat;PF13424,Tetratricopeptide repeat","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","KOG1840,Kinesin light chain;COG0457,FOG: TPR repeat","-","-"]
["KARS",65.42567349,23.13392589,1.499505499,7.499554161,{"v":4.41e-11,"d":"4.41E-11"},{"v":5.44e-10,"d":"5.44E-10"},"ENSG00000065427","H2QBJ3,Lysine--tRNA ligase","XP_003315273.1,lysine--tRNA ligase isoform X1;XP_009429550.1,-","PF00152,tRNA synthetases class II (D, K and N);PF01336,OB-fold nucleic acid binding domain","IPR004364,Aminoacyl-tRNA synthetase, class II (D/K/N);IPR004365,OB-fold nucleic acid binding domain, AA-tRNA synthetase-type;IPR002313,Lysine-tRNA ligase, class II;IPR006195,Aminoacyl-tRNA synthetase, class II;IPR018149,Lysyl-tRNA synthetase, class II, C-terminal;IPR012340,Nucleic acid-binding, OB-fold;IPR034762,Bacterial/eukaryotic lysine-tRNA ligase, class II","KOG1885,Lysyl-tRNA synthetase (class II);COG1190,Lysyl-tRNA synthetase (class II)","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0006430,biological_process,lysyl-tRNA aminoacylation;GO:0004824,molecular_function,lysine-tRNA ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","K04567,ko00970,Aminoacyl-tRNA biosynthesis"]
["GTF3C3",10.82858368,3.827736234,1.499101755,5.727913479,{"v":2.52e-08,"d":"2.52E-08"},{"v":1.69e-07,"d":"1.69E-07"},"ENSG00000119041","H2QJ67,General transcription factor IIIC, polypeptide 3, 102kDa","-","PF13181,Tetratricopeptide repeat","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","KOG2076,RNA polymerase III transcription factor TFIIIC;ENOG410XNW8,-","GO:0005730,cellular_component,nucleolus;GO:0000995,molecular_function,transcription factor activity, core RNA polymerase III binding;GO:0006359,biological_process,regulation of transcription by RNA polymerase III;GO:0031965,cellular_component,nuclear membrane;GO:0000127,cellular_component,transcription factor TFIIIC complex;GO:0005634,cellular_component,nucleus;GO:0006383,biological_process,transcription by RNA polymerase III","-"]
["NABP2",21.30503558,7.534191028,1.49775187,5.039612725,{"v":6.59e-07,"d":"6.59E-07"},{"v":3.23E-6,"d":"3.23E-06"},"ENSG00000139579","G3R0Z9,Nucleic acid binding protein 2","XP_004053414.1,-;XP_018893766.1,-;XP_018893765.1,-;XP_018893767.1,-","PF01336,OB-fold nucleic acid binding domain","IPR004365,OB-fold nucleic acid binding domain, AA-tRNA synthetase-type;IPR012340,Nucleic acid-binding, OB-fold","-","GO:0003697,molecular_function,single-stranded DNA binding;GO:0098505,molecular_function,G-rich strand telomeric DNA binding;GO:0070876,cellular_component,SOSS complex;GO:0000784,cellular_component,nuclear chromosome, telomeric region;GO:0003676,molecular_function,nucleic acid binding;GO:0070182,molecular_function,DNA polymerase binding;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:1904355,biological_process,positive regulation of telomere capping;GO:0010212,biological_process,response to ionizing radiation;GO:0006281,biological_process,DNA repair;GO:0005829,cellular_component,cytosol;GO:0007093,biological_process,mitotic cell cycle checkpoint;GO:0070200,biological_process,establishment of protein localization to telomere;GO:0005634,cellular_component,nucleus;GO:0000724,biological_process,double-strand break repair via homologous recombination;GO:0005654,cellular_component,nucleoplasm","-"]
["DLG3",18.28479446,6.474736612,1.497119761,6.615598132,{"v":7.1e-10,"d":"7.10E-10"},{"v":6.77e-09,"d":"6.77E-09"},"ENSG00000082458","Q5JUW8,Discs, large homolog 3","-","PF10600,PDZ-associated domain of NMDA receptors;PF00625,uanylate kinase;PF00595,PDZ domain (Also known as DHR or GLGF);PF00018,SH3 domain;PF10608,Polyubiquitination (PEST) N-terminal domain of MAGUK","IPR036034,PDZ superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR019583,PDZ-associated domain of NMDA receptors;IPR001478,PDZ domain;IPR019590,Disks large homologue 1, N-terminal PEST domain;IPR016313,Disks large 1-like;IPR035763,Disks Large homologue 3, SH3 domain;IPR036028,SH3-like domain superfamily;IPR020590,Guanylate kinase, conserved site;IPR008144,Guanylate kinase-like domain;IPR008145,Guanylate kinase/L-type calcium channel beta subunit;IPR001452,SH3 domain","COG0194,Guanylate kinase;KOG0708,Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains)","-","-"]
["GAA",5.572668266,1.970047866,1.496984324,4.344716326,{"v":1.79e-05,"d":"1.79E-05"},{"v":6.42e-05,"d":"6.42E-05"},"ENSG00000171298","A0A024R8Q1,Glucosidase, alpha acid","-","PF16863,N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase;PF13802,alactose mutarotase-like;PF01055,lycosyl hydrolases family 31;PF00088,Trefoil (P-type) domain","IPR030458,Glycosyl hydrolases family 31, active site;IPR011013,Galactose mutarotase-like domain superfamily;IPR031727,Galactose mutarotase, N-terminal barrel;IPR017957,P-type trefoil, conserved site;IPR017853,Glycoside hydrolase superfamily;IPR013780,Glycosyl hydrolase, all-beta;IPR030459,Glycosyl hydrolases family 31, conserved site;IPR000519,P-type trefoil domain;IPR000322,Glycoside hydrolase family 31;IPR025887,Glycoside hydrolase family 31, N-terminal domain","KOG1065,Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31;COG1501,Alpha-glucosidases, family 31 of glycosyl hydrolases","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0005975,biological_process,carbohydrate metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0003824,molecular_function,catalytic activity;GO:0004553,molecular_function,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0030246,molecular_function,carbohydrate binding;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["CDK19",4.944445097,1.749404405,1.496500854,4.698624392,{"v":3.72E-6,"d":"3.72E-06"},{"v":1.56E-5,"d":"1.56E-05"},"ENSG00000155111","K7DDU7,Cyclin-dependent kinase 19","XP_001146708.3,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XPPA,-;KOG0666,Cyclin C-dependent kinase CDK8","GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0016310,biological_process,phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["CAMSAP3",4.018933315,1.420213075,1.496054485,3.808980362,0.000172321,0.000495119,"ENSG00000076826","D6W648,HCG2004001, isoform CRA_b","-","PF17095,Spectrin-binding region of Ca2+-Calmodulin;PF08683,Microtubule-binding calmodulin-regulated spectrin-associated;PF11971,CAMSAP CH domain","IPR022613,Calmodulin-regulated spectrin-associated protein, CH domain;IPR011033,PRC-barrel-like superfamily;IPR036872,CH domain superfamily;IPR031372,CAMSAP, spectrin and Ca2+/calmodulin-binding region;IPR038209,CKK domain superfamily;IPR014797,CKK domain;IPR032940,Calmodulin-regulated spectrin-associated protein","KOG3654,Uncharacterized CH domain protein;ENOG4111D0B,-","GO:0005874,cellular_component,microtubule;GO:0030507,molecular_function,spectrin binding;GO:0031175,biological_process,neuron projection development;GO:0005516,molecular_function,calmodulin binding;GO:0008017,molecular_function,microtubule binding","-"]
["NECAP2",9.653893296,3.418686781,1.495983049,5.219180566,{"v":2.62e-07,"d":"2.62E-07"},{"v":1.4e-06,"d":"1.40E-06"},"ENSG00000157191","G3RDX4,NECAP endocytosis associated 2","XP_004024801.1,-","PF07933,Protein of unknown function (DUF1681)","IPR012466,NECAP, PHear domain;IPR011993,PH-like domain superfamily","-","GO:0006897,biological_process,endocytosis;GO:0016020,cellular_component,membrane","-"]
["ZBTB39",4.502890924,1.593177205,1.495688135,4.29842095,{"v":2.23E-5,"d":"2.23E-05"},{"v":7.86E-5,"d":"7.86E-05"},"ENSG00000166860","G3SH86,Zinc finger and BTB domain containing 39","XP_018893633.1,zinc finger and BTB domain-containing protein 39","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["KDM4A",16.43672313,5.828506757,1.494662141,5.870714728,{"v":1.61e-08,"d":"1.61E-08"},{"v":1.13e-07,"d":"1.13E-07"},"ENSG00000066135","K7ARH9,Lysine","-","PF13832,PHD-zinc-finger like domain;PF02375,jmjN domain;PF13831,PHD-finger;PF02373,JmjC domain, hydroxylase","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR003349,JmjN domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR034732,Extended PHD (ePHD) domain;IPR002999,Tudor domain;IPR003347,JmjC domain","-","GO:0032259,biological_process,methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0046872,molecular_function,metal ion binding;GO:0005634,cellular_component,nucleus","-"]
["HMGN4",53.68015843,19.03225662,1.494621686,5.562085225,{"v":5.46e-08,"d":"5.46E-08"},{"v":3.41E-7,"d":"3.41E-07"},"ENSG00000182952","K7C6V4,High mobility group nucleosomal binding domain 4","-","-","-","-","-","-"]
["RP11-697E2.12",51.80115138,18.34409249,1.494301589,4.250579278,{"v":2.79e-05,"d":"2.79E-05"},{"v":9.6e-05,"d":"9.60E-05"},"ENSG00000275674","A0A087WVE0,Uncharacterized protein","-","PF06413,Neugrin","IPR010487,Neugrin/Rrg9","-","GO:0005634,cellular_component,nucleus","-"]
["UNC5B",1.492586792,0.526867109,1.493446827,2.941432713,0.005120995,0.01047568,"ENSG00000107731","G3RY67,Unc-5 netrin receptor B","XP_004049602.1,netrin receptor UNC5B isoform X3","PF00791,ZU5 domain;PF00090,Thrombospondin type 1 domain;PF00531,eath domain;PF17217,UPA domain;PF07679,Immunoglobulin I-set domain","IPR007110,Immunoglobulin-like domain;IPR000906,ZU5 domain;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR011029,Death-like domain superfamily;IPR000488,Death domain;IPR037936,Netrin receptor UNC5;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR033772,UPA domain;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily","-","GO:0016021,cellular_component,integral component of membrane;GO:0038007,biological_process,netrin-activated signaling pathway;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0005042,molecular_function,netrin receptor activity;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0033564,biological_process,anterior/posterior axon guidance;GO:2001240,biological_process,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand","K07521,ko04360,Axon guidance"]
["RCAN1",4.891882821,1.734413086,1.493303605,4.58765349,{"v":5.3e-06,"d":"5.30E-06"},{"v":2.14e-05,"d":"2.14E-05"},"ENSG00000159200","E9PDJ2,Calcipressin-1","XP_016883772.1,-;NP_001272320.2,calcipressin-1 isoform e","PF04847,Calcipressin","IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR006931,Calcipressin;IPR035979,RNA-binding domain superfamily;IPR031271,Calcipressin-1","ENOG4111I50,-;KOG4019,Calcineurin-mediated signaling pathway inhibitor DSCR1","GO:0019722,biological_process,calcium-mediated signaling;GO:0003676,molecular_function,nucleic acid binding;GO:0051151,biological_process,negative regulation of smooth muscle cell differentiation;GO:0033173,biological_process,calcineurin-NFAT signaling cascade;GO:0007519,biological_process,skeletal muscle tissue development;GO:0009612,biological_process,response to mechanical stimulus;GO:0005622,cellular_component,intracellular;GO:0043627,biological_process,response to estrogen","-"]
["NPLOC4",15.99768056,5.681233746,1.492998091,6.710546659,{"v":5.66e-10,"d":"5.66E-10"},{"v":5.54e-09,"d":"5.54E-09"},"ENSG00000182446","H2QE26,Uncharacterized protein","-","PF05021,NPL4 family;PF11543,Nuclear pore localisation protein NPL4;PF05020,NPL4 family, putative zinc binding region","IPR037518,MPN domain;IPR007716,NPL4, zinc-binding putative;IPR036443,Zinc finger, RanBP2-type superfamily;IPR024682,Nuclear pore localisation protein Npl4, ubiquitin-like domain;IPR016563,Nuclear protein localization protein 4;IPR029071,Ubiquitin-like domain superfamily;IPR007717,Nuclear pore localisation protein NPL4, C-terminal;IPR001876,Zinc finger, RanBP2-type","KOG2834,Nuclear pore complex, rNpl4 component (sc Npl4);COG5100,Nuclear pore protein","GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0043130,molecular_function,ubiquitin binding;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0005634,cellular_component,nucleus","-"]
["ENTPD6",15.06692869,5.351364693,1.492284248,5.789667814,{"v":2.34e-08,"d":"2.34E-08"},{"v":1.58e-07,"d":"1.58E-07"},"ENSG00000197586","H2QZG6,Ectonucleoside triphosphate diphosphohydrolase 6","XP_009435225.1,-;XP_009435226.1,-","PF01150,A1/CD39 (nucleoside phosphatase) family","IPR000407,Nucleoside phosphatase GDA1/CD39","KOG1385,Nucleoside phosphatase;COG5371,Golgi nucleoside diphosphatase","GO:0016787,molecular_function,hydrolase activity","K01511,ko00230,Purine metabolism;K01511,ko00240,Pyrimidine metabolism"]
["CBFB",17.42562946,6.189815625,1.491990766,5.634677293,{"v":4.34e-08,"d":"4.34E-08"},{"v":2.77e-07,"d":"2.77E-07"},"ENSG00000067955","K7BM48,Core-binding factor, beta subunit","XP_016785487.1,-","PF02312,Core binding factor beta subunit","IPR003417,Core-binding factor, beta subunit;IPR036552,Core-binding factor, beta subunit superfamily","ENOG410Z04Q,-;KOG4785,Transcription factor CBF, beta subunit","GO:0003713,molecular_function,transcription coactivator activity;GO:0005634,cellular_component,nucleus;GO:1903506,biological_process,regulation of nucleic acid-templated transcription","-"]
["PLXNB1",1.805409509,0.639638904,1.491865266,3.669931057,0.000244433,0.000679271,"ENSG00000164050","H2QMJ0,Plexin B1","XP_016796518.1,-;XP_003309830.1,-;XP_003309829.1,plexin-B1 isoform X1","PF01437,Plexin repeat;PF01403,Sema domain;PF01833,IPT/TIG domain;PF08337,Plexin cytoplasmic RasGAP domain","IPR031148,Plexin family;IPR001627,Sema domain;IPR016201,PSI domain;IPR036352,Sema domain superfamily;IPR013548,Plexin, cytoplasmic RasGAP domain;IPR002165,Plexin repeat;IPR008936,Rho GTPase activation protein;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set;IPR002909,IPT domain","KOG3610,Plexins (functional semaphorin receptors);ENOG410XR88,-","GO:0043931,biological_process,ossification involved in bone maturation;GO:0016021,cellular_component,integral component of membrane;GO:1900220,biological_process,semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0071526,biological_process,semaphorin-plexin signaling pathway;GO:0007162,biological_process,negative regulation of cell adhesion;GO:0050772,biological_process,positive regulation of axonogenesis;GO:0002116,cellular_component,semaphorin receptor complex;GO:0043087,biological_process,regulation of GTPase activity;GO:0033689,biological_process,negative regulation of osteoblast proliferation;GO:0017154,molecular_function,semaphorin receptor activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0051493,biological_process,regulation of cytoskeleton organization;GO:0048675,biological_process,axon extension;GO:0032794,molecular_function,GTPase activating protein binding;GO:0016020,cellular_component,membrane;GO:0008360,biological_process,regulation of cell shape;GO:0005887,cellular_component,integral component of plasma membrane;GO:0007165,biological_process,signal transduction;GO:0048812,biological_process,neuron projection morphogenesis","K06821,ko04360,Axon guidance"]
["TRIOBP",16.93926351,6.024209441,1.491093433,7.144388541,{"v":1.45e-10,"d":"1.45E-10"},{"v":1.59e-09,"d":"1.59E-09"},"ENSG00000100106","A0A1S5UZ31,TRIO and F-actin-binding protein","-","-","IPR029908,TRIO and F-actin-binding protein;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","-","GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:0051015,molecular_function,actin filament binding","-"]
["ZMAT3",4.012648111,1.426691343,1.489559903,4.761702434,{"v":2.62e-06,"d":"2.62E-06"},{"v":1.13E-5,"d":"1.13E-05"},"ENSG00000172667","H2QNS0,Zinc finger matrin-type 3","-","PF12171,Zinc-finger double-stranded RNA-binding;PF12874,Zinc-finger of C2H2 type","IPR013087,Zinc finger C2H2-type;IPR003604,Matrin/U1-C-like, C2H2-type zinc finger;IPR036236,Zinc finger C2H2 superfamily;IPR022755,Zinc finger, double-stranded RNA binding","ENOG4110YZS,-;ENOG410IHBJ,-","GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0003723,molecular_function,RNA binding;GO:0072332,biological_process,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0005622,cellular_component,intracellular;GO:0002039,molecular_function,p53 binding;GO:0008270,molecular_function,zinc ion binding","-"]
["C20orf194",1.084292901,0.383635927,1.489220785,2.813997661,0.004402766,0.009166567,"ENSG00000088854","K6ZE24,Chromosome 20 open reading frame 194","XP_016792844.1,uncharacterized protein C20orf194 homolog isoform X1","-","-","ENOG410XS7X,-;ENOG410IFVP,-","-","-"]
["INSIG1",2.537245388,0.897708069,1.489220785,2.813997661,0.004402766,0.009166567,"ENSG00000186480","A0A024RD68,Insulin-induced gene protein","XP_016867666.1,-;NP_005533.2,insulin-induced gene 1 protein isoform 1;NP_001333521.1,-","PF07281,Insulin-induced protein (INSIG)","IPR025929,Insulin-induced protein family;IPR009904,Insulin-induced gene 1 protein","ENOG410XQ2M,-;KOG4363,Putative growth response protein","GO:0042472,biological_process,inner ear morphogenesis;GO:0045717,biological_process,negative regulation of fatty acid biosynthetic process;GO:0008202,biological_process,steroid metabolic process;GO:0006629,biological_process,lipid metabolic process;GO:0006695,biological_process,cholesterol biosynthetic process;GO:0008203,biological_process,cholesterol metabolic process;GO:0042474,biological_process,middle ear morphogenesis;GO:0060021,biological_process,roof of mouth development;GO:0006991,biological_process,response to sterol depletion;GO:0005783,cellular_component,endoplasmic reticulum;GO:0045599,biological_process,negative regulation of fat cell differentiation;GO:0016126,biological_process,sterol biosynthetic process;GO:0016020,cellular_component,membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0010894,biological_process,negative regulation of steroid biosynthetic process;GO:0006641,biological_process,triglyceride metabolic process;GO:0016021,cellular_component,integral component of membrane;GO:0060363,biological_process,cranial suture morphogenesis","-"]
["SH3GLB1",13.76930649,4.904713682,1.488268463,6.026511944,{"v":9.39E-9,"d":"9.39E-09"},{"v":6.95e-08,"d":"6.95E-08"},"ENSG00000097033","A0A087WW40,Endophilin-B1","NP_001193580.1,endophilin-B1 isoform 2","PF14604,Variant SH3 domain;PF03114,BAR domain","IPR004148,BAR domain;IPR028503,Endophilin-B1;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain;IPR027267,AH/BAR domain superfamily;IPR035695,Endophilin-B1, BAR domain","ENOG410XPA6,-;KOG3725,SH3 domain protein SH3GLB","GO:0008654,biological_process,phospholipid biosynthetic process;GO:0005504,molecular_function,fatty acid binding;GO:2000786,biological_process,positive regulation of autophagosome assembly;GO:0048102,biological_process,autophagic cell death;GO:0006654,biological_process,phosphatidic acid biosynthetic process;GO:0042171,molecular_function,lysophosphatidic acid acyltransferase activity;GO:0051084,biological_process,'de novo' posttranslational protein folding;GO:1903778,biological_process,protein localization to vacuolar membrane;GO:1900740,biological_process,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0005737,cellular_component,cytoplasm;GO:0005739,cellular_component,mitochondrion;GO:0043552,biological_process,positive regulation of phosphatidylinositol 3-kinase activity;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0010508,biological_process,positive regulation of autophagy","-"]
["IFITM3",32.76527227,11.66754107,1.487636962,4.947189996,{"v":1.01e-06,"d":"1.01E-06"},{"v":4.75e-06,"d":"4.75E-06"},"ENSG00000142089","G3RSJ4,Uncharacterized protein","XP_004050385.1,-","PF04505,Interferon-induced transmembrane protein","IPR007593,CD225/Dispanin family","-","GO:0009607,biological_process,response to biotic stimulus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GNG5",20.71369972,7.366534287,1.487632219,4.041416291,{"v":7.38e-05,"d":"7.38E-05"},0.000230336,"ENSG00000174021","M3Z5X6,Guanine nucleotide-binding protein subunit gamma","XP_004752749.1,-","PF00631,L domain","IPR001770,G-protein, gamma subunit;IPR036284,G-protein gamma-like domain superfamily;IPR015898,G-protein gamma-like domain","ENOG41122JF,-;KOG4119,G protein gamma subunit","GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0005834,cellular_component,heterotrimeric G-protein complex;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0007165,biological_process,signal transduction","-"]
["RBBP6",19.33706968,6.895139541,1.487264138,7.076447304,2.18E-10,{"v":2.32e-09,"d":"2.32E-09"},"ENSG00000122257","G3QW38,RB binding protein 6, ubiquitin ligase","XP_004057415.1,E3 ubiquitin-protein ligase RBBP6 isoform X2","PF04564,U-box domain;PF08783,WNN domain;PF13696,Zinc knuckle","IPR003613,U box domain;IPR033489,E3 ubiquitin-protein ligase RBBP6;IPR014891,DWNN domain;IPR036875,Zinc finger, CCHC-type superfamily;IPR001841,Zinc finger, RING-type;IPR001878,Zinc finger, CCHC-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR025829,Zinc knuckle CX2CX3GHX4C","-","GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0019901,molecular_function,protein kinase binding;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016567,biological_process,protein ubiquitination;GO:0003676,molecular_function,nucleic acid binding;GO:0032991,cellular_component,protein-containing complex;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0035264,biological_process,multicellular organism growth;GO:0048568,biological_process,embryonic organ development;GO:0006397,biological_process,mRNA processing;GO:0001701,biological_process,in utero embryonic development;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016607,cellular_component,nuclear speck;GO:0005813,cellular_component,centrosome;GO:0005634,cellular_component,nucleus;GO:0006275,biological_process,regulation of DNA replication;GO:0061053,biological_process,somite development;GO:0008270,molecular_function,zinc ion binding","-"]
["RALGPS2",15.42016197,5.497948414,1.487219708,6.599082084,{"v":1e-09,"d":"1.00E-09"},{"v":9.22e-09,"d":"9.22E-09"},"ENSG00000116191","H2N4J9,Ral GEF with PH domain and SH3 binding motif 2","XP_002809803.1,ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1","PF00617,RasGEF domain;PF00169,PH domain","IPR030708,Ras-specific guanine nucleotide-releasing factor RalGPS1/2;IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR036964,Ras guanine-nucleotide exchange factor catalytic domain superfamily","ENOG410IQ6R,-;ENOG410YV9P,-","GO:0032485,biological_process,regulation of Ral protein signal transduction;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005622,cellular_component,intracellular","-"]
["RP11-84G21.1",4.846125414,1.722411431,1.486679582,3.515843597,0.000588384,0.001498476,"ENSG00000257557","G1RAE7,Uncharacterized protein","-","-","-","-","-","-"]
["C8orf44-SGK3",5.276892117,1.875514669,1.486679582,3.515843597,0.000588384,0.001498476,"ENSG00000270024","G1RIT6,Uncharacterized protein","-","PF00433,Protein kinase C terminal domain;PF00069,Protein kinase domain;PF00787,PX domain","IPR036871,PX domain superfamily;IPR037709,Serine/threonine-protein kinase Sgk3, catalytic domain;IPR017892,Protein kinase, C-terminal;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR001683,Phox homologous domain;IPR000719,Protein kinase domain","KOG2101,Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s);ENOG410XNPH,-;KOG0598,Ribosomal protein S6 kinase and related proteins","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:2001240,biological_process,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0035091,molecular_function,phosphatidylinositol binding","K13304,ko04151,PI3K-Akt signaling pathway;K13304,ko04068,FoxO signaling pathway"]
["PCF11",7.015705227,2.502504454,1.485933889,5.593475588,{"v":5.97e-08,"d":"5.97E-08"},{"v":3.69e-07,"d":"3.69E-07"},"ENSG00000165494","K7DP94,PCF11, cleavage and polyadenylation factor subunit, homolog","XP_016777944.1,pre-mRNA cleavage complex 2 protein Pcf11 isoform X7","PF04818,RNA polymerase II-binding domain.","IPR006903,RNA polymerase II-binding domain;IPR008942,ENTH/VHS;IPR006569,CID domain","ENOG410Y266,-;KOG2071,mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11","-","-"]
["FOXK1",8.415298817,3.003101918,1.485749305,6.242108828,{"v":3.84E-9,"d":"3.84E-09"},{"v":3.1E-8,"d":"3.10E-08"},"ENSG00000164916","H2R3X7,Forkhead box K1","XP_003318328.1,forkhead box protein K1","PF00250,orkhead domain;PF00498,HA domain","IPR001766,Fork head domain;IPR018122,Fork head domain conserved site1;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR000253,Forkhead-associated (FHA) domain;IPR008984,SMAD/FHA domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036390,Winged helix DNA-binding domain superfamily","KOG2294,Transcription factor of the Forkhead/HNF3 family;COG5025,Transcription factor of the Forkhead/HNF3 family","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0030154,biological_process,cell differentiation;GO:0009653,biological_process,anatomical structure morphogenesis;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["UHMK1",4.571480193,1.630166393,1.485525648,4.886021198,{"v":1.63e-06,"d":"1.63E-06"},{"v":7.4e-06,"d":"7.40E-06"},"ENSG00000152332","H0XEN7,U2AF homology motif kinase 1","XP_003785804.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034371,UHMK1, RNA recognition motif;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR034372,Serine/threonine-protein kinase Kist;IPR000719,Protein kinase domain","KOG0032,Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily;ENOG410XRMJ,-","GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0005794,cellular_component,Golgi apparatus;GO:0046825,biological_process,regulation of protein export from nucleus;GO:0046777,biological_process,protein autophosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0007050,biological_process,cell cycle arrest;GO:0003676,molecular_function,nucleic acid binding;GO:0030424,cellular_component,axon;GO:0005634,cellular_component,nucleus;GO:0071598,cellular_component,neuronal ribonucleoprotein granule;GO:0043021,molecular_function,ribonucleoprotein complex binding;GO:0003723,molecular_function,RNA binding;GO:0032839,cellular_component,dendrite cytoplasm;GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0045948,biological_process,positive regulation of translational initiation;GO:0031175,biological_process,neuron projection development;GO:0005524,molecular_function,ATP binding;GO:0005654,cellular_component,nucleoplasm","-"]
["ARHGAP29",6.149122546,2.195117128,1.485146251,6.037966504,{"v":8.76e-09,"d":"8.76E-09"},{"v":6.52e-08,"d":"6.52E-08"},"ENSG00000137962","G3QIM1,Rho GTPase activating protein 29","XP_004026209.1,rho GTPase-activating protein 29","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR000198,Rho GTPase-activating protein domain;IPR027267,AH/BAR domain superfamily;IPR031160,F-BAR domain","-","GO:0035556,biological_process,intracellular signal transduction;GO:0030165,molecular_function,PDZ domain binding;GO:0046872,molecular_function,metal ion binding;GO:0005737,cellular_component,cytoplasm;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0007165,biological_process,signal transduction","-"]
["2020-09-08",25.09791446,8.966020868,1.484566215,7.04756891,{"v":2.38e-10,"d":"2.38E-10"},{"v":2.5e-09,"d":"2.50E-09"},"ENSG00000164402","A0A096N4P0,Septin 8","-","PF00735,Septin","IPR030379,Septin-type guanine nucleotide-binding (G) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR030646,Septin 8;IPR016491,Septin","-","GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding","-"]
["CREM",1.458344461,0.517454116,1.484049644,2.673949491,0.009165782,0.01761884,"ENSG00000095794","J3KQC0,cAMP-responsive element modulator","-","PF00170,bZIP transcription factor;PF02173,pKID domain","IPR003102,Coactivator CBP, pKID;IPR001630,cAMP response element binding (CREB) protein;IPR004827,Basic-leucine zipper domain","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["RP11-37B2.1",1.110961781,0.394194761,1.484049644,2.673949491,0.009165782,0.01761884,"-","-","-","-","-","-","-","-"]
["SNUPN",6.010794349,2.143418441,1.483415692,3.924120318,{"v":9.99e-05,"d":"9.99E-05"},3.01947E-4,"ENSG00000169371","G2HET3,Snurportin-1","XP_016782713.1,-;XP_016782716.1,-;NP_001315246.1,snurportin 1;XP_016782712.1,-;XP_016782717.1,-;XP_016782715.1,-","PF11538,Snurportin1","IPR002652,Importin-alpha, importin-beta-binding domain;IPR017336,Snurportin-1;IPR024721,Snurportin-1, N-terminal","KOG3132,m3G-cap-specific nuclear import receptor (Snurportin1);ENOG410ZRBH,-","GO:0061608,molecular_function,nuclear import signal receptor activity;GO:0005737,cellular_component,cytoplasm;GO:0006606,biological_process,protein import into nucleus;GO:0003723,molecular_function,RNA binding;GO:0061015,biological_process,snRNA import into nucleus;GO:0005634,cellular_component,nucleus;GO:0008565,molecular_function,protein transporter activity","K13151,ko03013,RNA transport"]
["PPIP5K2",3.024970004,1.081460126,1.482234243,5.184675381,{"v":4.05e-07,"d":"4.05E-07"},{"v":2.07e-06,"d":"2.07E-06"},"ENSG00000145725","A0A087WZV0,Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2","NP_001268400.1,inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 3","PF00328,Histidine phosphatase superfamily (branch 2)","IPR037446,Histidine acid phosphatase, VIP1 family;IPR029033,Histidine phosphatase superfamily;IPR000560,Histidine phosphatase superfamily, clade-2;IPR033379,Histidine acid phosphatase active site","KOG1057,Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton;ENOG410XNSN,-","GO:0000828,molecular_function,inositol hexakisphosphate kinase activity;GO:0000829,molecular_function,inositol heptakisphosphate kinase activity;GO:0016310,biological_process,phosphorylation;GO:0033857,molecular_function,diphosphoinositol-pentakisphosphate kinase activity","-"]
["PIGS",6.580698517,2.352174981,1.481984392,4.789088439,{"v":2.21E-6,"d":"2.21E-06"},{"v":9.73E-6,"d":"9.73E-06"},"ENSG00000087111","Q8NBL9,cDNA PSEC0119 fis, clone PLACE1002376, highly similar to GPI transamidase component PIG-S","NP_149975.1,GPI transamidase component PIG-S","PF10510,Phosphatidylinositol-glycan biosynthesis class S protein","IPR019540,Phosphatidylinositol-glycan biosynthesis class S protein","ENOG410XR9U,-;KOG2459,GPI transamidase complex, GPI17/PIG-S component, involved in glycosylphosphatidylinositol anchor biosynthesis","GO:0042765,cellular_component,GPI-anchor transamidase complex;GO:0016255,biological_process,attachment of GPI anchor to protein;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K05291,ko00563,Glycosylphosphatidylinositol(GPI)-anchor biosynthesis"]
["BTBD9",2.788669002,0.996355238,1.481494051,4.241339265,{"v":3.47e-05,"d":"3.47E-05"},1.16691E-4,"ENSG00000183826","K7B4N3,BTB","XP_009449460.1,-;XP_009449461.1,-","PF00754,5/8 type C domain;PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch","IPR000421,Coagulation factor 5/8 C-terminal domain;IPR011705,BTB/Kelch-associated;IPR011333,SKP1/BTB/POZ domain superfamily;IPR034091,BTBD9, BACK-like domain;IPR000210,BTB/POZ domain;IPR008979,Galactose-binding-like domain superfamily","KOG4350,Uncharacterized conserved protein, contains BTB/POZ domain;ENOG410Z7D9,-","GO:0007616,biological_process,long-term memory;GO:0042428,biological_process,serotonin metabolic process;GO:0008344,biological_process,adult locomotory behavior;GO:1900242,biological_process,regulation of synaptic vesicle endocytosis;GO:0050951,biological_process,sensory perception of temperature stimulus;GO:0060586,biological_process,multicellular organismal iron ion homeostasis;GO:0042748,biological_process,circadian sleep/wake cycle, non-REM sleep;GO:0048512,biological_process,circadian behavior","-"]
["VSIG10",7.56459864,2.707638049,1.480819864,5.453092701,{"v":1.02E-7,"d":"1.02E-07"},{"v":5.94e-07,"d":"5.94E-07"},"ENSG00000176834","A0A024RBM1,Uncharacterized protein","-","PF13927,Immunoglobulin domain;PF07686,Immunoglobulin V-set domain;PF00047,Immunoglobulin domain","IPR007110,Immunoglobulin-like domain;IPR013151,Immunoglobulin;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain","ENOG4111I6E,-;ENOG410IIKX,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["FGD6",5.012101832,1.794254229,1.480264627,5.132987985,{"v":6.18e-07,"d":"6.18E-07"},{"v":3.05E-6,"d":"3.05E-06"},"ENSG00000180263","H2Q6M5,FYVE, RhoGEF and PH domain containing 6","-","PF00621,RhoGEF domain;PF01363,YVE zinc finger;PF00169,PH domain","IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR001849,Pleckstrin homology domain;IPR035899,Dbl homology (DH) domain superfamily","ENOG410IUBB,-;ENOG410XRXV,-","GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0046872,molecular_function,metal ion binding;GO:0065009,biological_process,regulation of molecular function","-"]
["LDAH",3.106855048,1.108719079,1.480093856,3.343038682,1.489598E-3,3.459677E-3,"ENSG00000118961","B5MDU6,Lipid droplet-associated hydrolase","-","PF10230,Lipid-droplet associated hydrolase","IPR019363,Lipid droplet-associated hydrolase;IPR029058,Alpha/Beta hydrolase fold","KOG3975,Uncharacterized conserved protein;ENOG410ZTV7,-","-","-"]
["MRPS10",42.87787457,15.37378249,1.478779986,5.963262106,{"v":1.35E-8,"d":"1.35E-08"},{"v":9.65e-08,"d":"9.65E-08"},"ENSG00000048544","A0A024RD03,Mitochondrial ribosomal protein S10, isoform CRA_a","NP_060611.2,28S ribosomal protein S10, mitochondrial","PF00338,Ribosomal protein S10p/S20e","IPR027486,Ribosomal protein S10 domain;IPR036838,Ribosomal protein S10 domain superfamily","KOG3321,Mitochondrial ribosomal protein S10;COG0051,Ribosomal protein S10","GO:0005840,cellular_component,ribosome","K02946,ko03010,Ribosome"]
["CYB5D1",7.815899254,2.799134958,1.478575749,4.459450697,{"v":1.43E-5,"d":"1.43E-05"},{"v":5.25e-05,"d":"5.25E-05"},"ENSG00000182224","G3RH33,Cytochrome b5 domain containing 1","XP_004058572.1,-","PF00173,Cytochrome b5-like Heme/Steroid binding domain","IPR001199,Cytochrome b5-like heme/steroid binding domain;IPR036400,Cytochrome b5-like heme/steroid binding domain superfamily","-","-","-"]
["MANBA",2.279752491,0.815566238,1.478383912,3.796325813,0.000221149,0.000618948,"ENSG00000109323","A8K6D3,cDNA FLJ75873, highly similar to Homo sapiens mannosidase, beta A, lysosomal","-","PF02836,lycosyl hydrolases family 2, TIM barrel domain","IPR017853,Glycoside hydrolase superfamily;IPR008979,Galactose-binding-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR036156,Beta-Galactosidase/glucuronidase domain superfamily;IPR006103,Glycoside hydrolase family 2, catalytic domain","COG3250,Beta-galactosidase/beta-glucuronidase;KOG2230,Predicted beta-mannosidase","GO:0004553,molecular_function,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005975,biological_process,carbohydrate metabolic process","-"]
["TAF9B",6.891534134,2.465400339,1.478383912,3.796325813,0.000221149,0.000618948,"ENSG00000187325","A0A0A0MXT0,Transcription initiation factor TFIID subunit 9B","-","PF02291,Transcription initiation factor IID, 31kD subunit","IPR003162,Transcription initiation factor TAFII31;IPR009072,Histone-fold","KOG3334,Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA);COG5094,Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA)","GO:0030307,biological_process,positive regulation of cell growth;GO:0050821,biological_process,protein stabilization;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0033276,cellular_component,transcription factor TFTC complex;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006352,biological_process,DNA-templated transcription, initiation;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005669,cellular_component,transcription factor TFIID complex","-"]
["ANKRD49",2.087709729,0.743422451,1.477576405,2.51849566,0.014056276,0.025822792,"ENSG00000168876","G3QYS9,Ankyrin repeat domain 49","XP_018892974.1,-;XP_004052031.1,-","PF12796,Ankyrin repeats (3 copies);PF13857,Ankyrin repeats (many copies);PF13637,Ankyrin repeats (many copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","-","GO:0045893,biological_process,positive regulation of transcription, DNA-templated","-"]
["ZNF594",1.385258657,0.49328332,1.477576405,2.51849566,0.014056276,0.025822792,"ENSG00000180626","D3DTM0,HCG1775942, isoform CRA_a","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR003656,Zinc finger, BED-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["CTD-2545M3.2",19.63003868,6.990153495,1.477576405,2.51849566,0.014056276,0.025822792,"ENSG00000268854","K7C9H8,Chromosome 19 open reading frame 63","XP_016792141.1,ER membrane protein complex subunit 10 isoform X1","-","IPR029615,ER membrane protein complex subunit 10","ENOG4111PEN,-;KOG4827,Uncharacterized conserved protein","-","-"]
["SENP7",1.150916902,0.409835454,1.477576405,2.51849566,0.014056276,0.025822792,"ENSG00000138468","H2QN10,SUMO1/sentrin specific peptidase 7","XP_001146607.1,sentrin-specific protease 7 isoform X2","PF02902,Ulp1 protease family, C-terminal catalytic domain","IPR003653,Ulp1 protease family, C-terminal catalytic domain","COG5160,Protease, Ulp1 family;KOG0779,Protease, Ulp1 family","GO:0006508,biological_process,proteolysis;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0005622,cellular_component,intracellular;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0007188,biological_process,adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0005634,cellular_component,nucleus;GO:0005886,cellular_component,plasma membrane","-"]
["ZNF513",10.44222203,3.740766603,1.477430117,4.139889828,{"v":4.51e-05,"d":"4.51E-05"},0.00014817,"ENSG00000163795","G3R5Y3,Zinc finger protein 513","XP_004029066.1,zinc finger protein 513 isoform X1","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003677,molecular_function,DNA binding;GO:0060041,biological_process,retina development in camera-type eye;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0005634,cellular_component,nucleus;GO:0003676,molecular_function,nucleic acid binding","-"]
["ABHD12",20.49816361,7.357855139,1.476876941,5.605370693,{"v":6.98e-08,"d":"6.98E-08"},{"v":4.24e-07,"d":"4.24E-07"},"ENSG00000100997","K7AWG2,Abhydrolase domain containing 12","XP_016793074.1,-","PF12697,Alpha/beta hydrolase family;PF00561,alpha/beta hydrolase fold;PF12146,Serine aminopeptidase, S33","IPR026605,Monoacylglycerol lipase protein ABHD12;IPR022742,Serine aminopeptidase, S33;IPR029058,Alpha/Beta hydrolase fold","COG1073,Hydrolases of the alpha/beta superfamily;KOG1552,Predicted alpha/beta hydrolase","GO:0007628,biological_process,adult walking behavior;GO:0016787,molecular_function,hydrolase activity;GO:0006660,biological_process,phosphatidylserine catabolic process;GO:0004622,molecular_function,lysophospholipase activity;GO:0005737,cellular_component,cytoplasm;GO:0046464,biological_process,acylglycerol catabolic process;GO:0010996,biological_process,response to auditory stimulus;GO:0052651,biological_process,monoacylglycerol catabolic process;GO:0002084,biological_process,protein depalmitoylation;GO:0032839,cellular_component,dendrite cytoplasm;GO:0016021,cellular_component,integral component of membrane;GO:0046475,biological_process,glycerophospholipid catabolic process;GO:0016020,cellular_component,membrane;GO:0008474,molecular_function,palmitoyl-(protein) hydrolase activity;GO:0032281,cellular_component,AMPA glutamate receptor complex;GO:0047372,molecular_function,acylglycerol lipase activity","-"]
["TAOK3",29.94648757,10.75678481,1.476860065,7.755420817,{"v":4.96e-11,"d":"4.96E-11"},{"v":6.06e-10,"d":"6.06E-10"},"ENSG00000135090","G1QHM6,TAO kinase 3","XP_003274500.1,serine/threonine-protein kinase TAO3;XP_003274501.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410Y259,-;KOG0577,Serine/threonine protein kinase","GO:0006468,biological_process,protein phosphorylation;GO:0046777,biological_process,protein autophosphorylation;GO:0032874,biological_process,positive regulation of stress-activated MAPK cascade;GO:0000165,biological_process,MAPK cascade;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0007095,biological_process,mitotic G2 DNA damage checkpoint;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005622,cellular_component,intracellular;GO:0046329,biological_process,negative regulation of JNK cascade;GO:0043507,biological_process,positive regulation of JUN kinase activity;GO:0046330,biological_process,positive regulation of JNK cascade;GO:0004672,molecular_function,protein kinase activity","K04429,ko04010,MAPK signaling pathway"]
["MARK1",5.567184503,1.99610369,1.476821728,4.416764375,{"v":1.17E-5,"d":"1.17E-05"},{"v":4.37e-05,"d":"4.37E-05"},"ENSG00000116141","A0A087X0I6,Non-specific serine/threonine protein kinase","NP_001273053.1,serine/threonine-protein kinase MARK1 isoform 1","PF02149,Kinase associated domain 1;PF00627,UBA/TS-N domain;PF00069,Protein kinase domain","IPR033627,Serine/threonine-protein kinase MARK1;IPR028375,KA1 domain/Ssp2, C-terminal;IPR033624,Serine/threonine-protein kinase MARK/par1;IPR015940,Ubiquitin-associated domain;IPR001772,Kinase associated domain 1 (KA1);IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0586,Serine/threonine protein kinase;ENOG410XNQ0,-","GO:0030010,biological_process,establishment of cell polarity;GO:0016301,molecular_function,kinase activity;GO:0050321,molecular_function,tau-protein kinase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0007010,biological_process,cytoskeleton organization;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0016740,molecular_function,transferase activity;GO:0000287,molecular_function,magnesium ion binding;GO:0005524,molecular_function,ATP binding;GO:0005856,cellular_component,cytoskeleton;GO:0004672,molecular_function,protein kinase activity;GO:0001764,biological_process,neuron migration;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["CABIN1",4.37586335,1.570606629,1.476090187,4.848403384,{"v":2.29e-06,"d":"2.29E-06"},{"v":1.01E-5,"d":"1.01E-05"},"ENSG00000099991","A0A024R1E5,Calcineurin binding protein 1, isoform CRA_a","NP_036427.1,calcineurin-binding protein cabin-1 isoform a;NP_001186210.1,-","PF09047,MEF2 binding","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR033053,Histone transcription regulator 3/CABIN1;IPR015134,Calcineurin-binding protein cabin-1, MEF2-binding domain;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","ENOG410IFFG,-;ENOG410XY91,-","GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0016235,cellular_component,aggresome;GO:0006336,biological_process,DNA replication-independent nucleosome assembly","-"]
["TMEM199",2.775508192,0.992919531,1.476085944,3.248067413,1.266002E-3,0.002986634,"ENSG00000244045","H2QCH1,Transmembrane protein 199","NP_001229551.1,-","PF11712,ndoplasmic reticulum-based factor for assembly of V-ATPase","IPR021013,ATPase, vacuolar ER assembly factor, Vma12","ENOG410IX23,-;ENOG4111IQS,-","GO:0036295,biological_process,cellular response to increased oxygen levels;GO:0005764,cellular_component,lysosome;GO:0016020,cellular_component,membrane;GO:1905146,biological_process,lysosomal protein catabolic process;GO:0030663,cellular_component,COPI-coated vesicle membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016471,cellular_component,vacuolar proton-transporting V-type ATPase complex;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0070072,biological_process,vacuolar proton-transporting V-type ATPase complex assembly;GO:0033116,cellular_component,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0007042,biological_process,lysosomal lumen acidification;GO:0016021,cellular_component,integral component of membrane","-"]
["MAP3K3",2.994011984,1.07307498,1.475484651,3.727865398,0.000294643,0.000804037,"ENSG00000198909","A0A0D9QV48,Mitogen-activated protein kinase kinase kinase 3","XP_008010347.1,-","PF00069,Protein kinase domain;PF00564,PB1 domain","IPR034879,Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain;IPR000270,PB1 domain;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","-","GO:0090050,biological_process,positive regulation of cell migration involved in sprouting angiogenesis;GO:2000773,biological_process,negative regulation of cellular senescence;GO:0035556,biological_process,intracellular signal transduction;GO:0046777,biological_process,protein autophosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0005622,cellular_component,intracellular;GO:1900745,biological_process,positive regulation of p38MAPK cascade;GO:0071864,biological_process,positive regulation of cell proliferation in bone marrow;GO:0006468,biological_process,protein phosphorylation;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0005524,molecular_function,ATP binding;GO:0001568,biological_process,blood vessel development","K04421,ko04722,Neurotrophin signaling pathway;K04421,ko04912,GnRH signaling pathway;K04421,ko04010,MAPK signaling pathway;K04421,ko05166,HTLV-I infection"]
["FAM107B",47.12665371,16.94569462,1.475357146,7.81906229,{"v":4.63e-11,"d":"4.63E-11"},{"v":5.7E-10,"d":"5.70E-10"},"ENSG00000065809","H2Q1N0,Family with sequence similarity 107 member B","XP_009456259.1,-","PF06625,Protein of unknown function (DUF1151)","IPR009533,Protein of unknown function DUF1151","ENOG410IVZ4,-;ENOG4111QFW,-","-","-"]
["CTA-797E19.2",79.58473534,28.57010965,1.4749561,4.372767556,{"v":1.78e-05,"d":"1.78E-05"},{"v":6.4e-05,"d":"6.40E-05"},"ENSG00000255539","A0A218U8G5,Liprin-alpha-3","-","-","IPR030440,Liprin-alpha-3;IPR029515,LAR-interacting protein, Liprin","-","GO:0007269,biological_process,neurotransmitter secretion;GO:0048786,cellular_component,presynaptic active zone","-"]
["PMPCA",8.575950619,3.082721335,1.474528193,5.297521125,{"v":2.55e-07,"d":"2.55E-07"},{"v":1.36e-06,"d":"1.36E-06"},"ENSG00000165688","G2HF22,Mitochondrial-processing peptidase alpha subunit, mitochondrial","NP_001267399.1,mitochondrial-processing peptidase subunit alpha","PF05193,Peptidase M16 inactive domain;PF00675,Insulinase (Peptidase family M16)","IPR001431,Peptidase M16, zinc-binding site;IPR011765,Peptidase M16, N-terminal;IPR037715,Mitochondrial-processing peptidase subunit alpha;IPR011249,Metalloenzyme, LuxS/M16 peptidase-like;IPR007863,Peptidase M16, C-terminal","COG0612,Predicted Zn-dependent peptidases;KOG2067,Mitochondrial processing peptidase, alpha subunit","GO:0006508,biological_process,proteolysis;GO:0003824,molecular_function,catalytic activity;GO:0046872,molecular_function,metal ion binding;GO:0006627,biological_process,protein processing involved in protein targeting to mitochondrion;GO:0005739,cellular_component,mitochondrion;GO:0004222,molecular_function,metalloendopeptidase activity","-"]
["ERCC2",5.227804749,1.879619762,1.473146157,4.573061179,{"v":7.83e-06,"d":"7.83E-06"},{"v":3.05e-05,"d":"3.05E-05"},"ENSG00000104884","G3RIG3,ERCC excision repair 2, TFIIH core complex helicase subunit","-","PF13307,Helicase C-terminal domain;PF06777,Helical and beta-bridge domain;PF06733,AD_2","IPR013020,ATP-dependent helicase Rad3/Chl1-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR006554,Helicase-like, DEXD box c2 type;IPR010643,Helical and beta-bridge domain;IPR014013,Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type;IPR010614,DEAD2;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR006555,ATP-dependent helicase, C-terminal;IPR001945,RAD3/XPD family","-","GO:0004386,molecular_function,helicase activity;GO:0003677,molecular_function,DNA binding;GO:0016787,molecular_function,hydrolase activity;GO:0016818,molecular_function,hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0005634,cellular_component,nucleus;GO:0008026,molecular_function,ATP-dependent helicase activity;GO:0006289,biological_process,nucleotide-excision repair;GO:0003676,molecular_function,nucleic acid binding;GO:0032508,biological_process,DNA duplex unwinding;GO:0004003,molecular_function,ATP-dependent DNA helicase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0006139,biological_process,nucleobase-containing compound metabolic process","K10844,ko03022,Basal transcription factors;K10844,ko03420,Nucleotide excision repair"]
["AP3D1",40.72244091,14.66694877,1.47300345,7.901864815,4.22E-11,{"v":5.23e-10,"d":"5.23E-10"},"ENSG00000065000","G3QUN8,AP-3 complex subunit delta","XP_004059738.1,AP-3 complex subunit delta-1 isoform X1","PF06375,AP-3 complex subunit delta-1;PF01602,Adaptin N terminal region","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR002553,Clathrin/coatomer adaptor, adaptin-like, N-terminal;IPR017105,Adaptor protein complex AP-3, delta subunit","-","GO:0048007,biological_process,antigen processing and presentation, exogenous lipid antigen via MHC class Ib;GO:1904115,cellular_component,axon cytoplasm;GO:0019882,biological_process,antigen processing and presentation;GO:0008089,biological_process,anterograde axonal transport;GO:0005886,cellular_component,plasma membrane;GO:0048490,biological_process,anterograde synaptic vesicle transport;GO:0072657,biological_process,protein localization to membrane;GO:0005794,cellular_component,Golgi apparatus;GO:0033365,biological_process,protein localization to organelle;GO:0051138,biological_process,positive regulation of NK T cell differentiation;GO:0048499,biological_process,synaptic vesicle membrane organization;GO:0098943,biological_process,neurotransmitter receptor transport, postsynaptic endosome to lysosome;GO:0030117,cellular_component,membrane coat;GO:0030123,cellular_component,AP-3 adaptor complex;GO:0030424,cellular_component,axon;GO:0098830,cellular_component,presynaptic endosome;GO:0035646,biological_process,endosome to melanosome transport;GO:0016020,cellular_component,membrane;GO:0015031,biological_process,protein transport;GO:0016192,biological_process,vesicle-mediated transport;GO:0061088,biological_process,regulation of sequestering of zinc ion;GO:0010008,cellular_component,endosome membrane;GO:0006886,biological_process,intracellular protein transport;GO:0043195,cellular_component,terminal bouton","K12396,ko04142,Lysosome"]
["RP11-661O13.1",77.02232918,27.72536843,1.472602033,5.384326317,{"v":2.15e-07,"d":"2.15E-07"},{"v":1.17E-6,"d":"1.17E-06"},"ENSG00000266708","A0A1A6GY27,Uncharacterized protein","-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding","-"]
["NUMB",8.540620467,3.075651297,1.472489467,5.987095925,{"v":1.29E-8,"d":"1.29E-08"},{"v":9.28e-08,"d":"9.28E-08"},"ENSG00000133961","A0A024R6F4,Numb homolog","NP_001005743.1,protein numb homolog isoform 1","PF00640,Phosphotyrosine interaction domain (PTB/PID);PF06311,NUMB domain","IPR016698,Numb/numb-like;IPR006020,PTB/PI domain;IPR010449,NUMB domain;IPR011993,PH-like domain superfamily","KOG3537,Adaptor protein NUMB;ENOG410XT15,-","GO:0034332,biological_process,adherens junction organization;GO:0007409,biological_process,axonogenesis;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0005737,cellular_component,cytoplasm;GO:0050769,biological_process,positive regulation of neurogenesis;GO:0016323,cellular_component,basolateral plasma membrane;GO:0007405,biological_process,neuroblast proliferation;GO:0008013,molecular_function,beta-catenin binding;GO:0021670,biological_process,lateral ventricle development;GO:0007399,biological_process,nervous system development;GO:0005769,cellular_component,early endosome;GO:0045296,molecular_function,cadherin binding;GO:0030900,biological_process,forebrain development;GO:0019897,cellular_component,extrinsic component of plasma membrane;GO:0021849,biological_process,neuroblast division in subventricular zone;GO:0005634,cellular_component,nucleus;GO:0045177,cellular_component,apical part of cell;GO:0045294,molecular_function,alpha-catenin binding","K06057,ko04330,Notch signaling pathway"]
["RP11-56B16.4",33.98939334,12.20706952,1.472275095,3.655952934,0.000317855,0.000859561,"-","-","-","-","-","-","-","-"]
["TINAGL1",23.24690307,8.376172143,1.4719578,6.399931433,{"v":2.54e-09,"d":"2.54E-09"},{"v":2.13e-08,"d":"2.13E-08"},"ENSG00000142910","K7D3X3,Tubulointerstitial nephritis antigen-like 1","XP_016813428.1,-","PF00112,Papain family cysteine protease","IPR025660,Cysteine peptidase, histidine active site;IPR001212,Somatomedin B domain;IPR013128,Peptidase C1A;IPR000668,Peptidase C1A, papain C-terminal","ENOG410YN9K,-;KOG1544,Predicted cysteine proteinase TIN-ag","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0006508,biological_process,proteolysis;GO:0005044,molecular_function,scavenger receptor activity;GO:0030247,molecular_function,polysaccharide binding;GO:0043236,molecular_function,laminin binding;GO:0031012,cellular_component,extracellular matrix;GO:0006955,biological_process,immune response;GO:0005737,cellular_component,cytoplasm;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0005615,cellular_component,extracellular space","-"]
["CTB-58E17.9",21.08882285,7.565941005,1.471452517,3.146290471,0.002418425,0.005369716,"ENSG00000275665","A0A0D9S3G7,MLLT6, PHD finger containing","XP_008011103.1,protein AF-17 isoform X1","PF13832,PHD-zinc-finger like domain;PF13831,PHD-finger","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR034732,Extended PHD (ePHD) domain;IPR019786,Zinc finger, PHD-type, conserved site","-","GO:0003014,biological_process,renal system process;GO:0010765,biological_process,positive regulation of sodium ion transport;GO:0046872,molecular_function,metal ion binding;GO:0035811,biological_process,negative regulation of urine volume;GO:0007588,biological_process,excretion;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0036359,biological_process,renal potassium excretion;GO:2001161,biological_process,negative regulation of histone H3-K79 methylation;GO:0035812,biological_process,renal sodium excretion","-"]
["PIK3R2",38.36944434,13.83371309,1.471262232,6.89524982,{"v":5.07e-10,"d":"5.07E-10"},{"v":5e-09,"d":"5.00E-09"},"ENSG00000105647","A0A024R7N6,Phosphoinositide-3-kinase, regulatory subunit 2","-","PF00017,SH2 domain;PF00620,RhoGAP domain;PF16454,Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain","IPR036860,SH2 domain superfamily;IPR001720,PI3K p85/p55 subunit;IPR000980,SH2 domain;IPR035022,PI3K p85 subunit, N-terminal SH2 domain;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain;IPR008936,Rho GTPase activation protein;IPR035020,PI3K p85 subunit, C-terminal SH2 domain;IPR032498,PI3K p85 subunit, inter-SH2 domain;IPR035586,Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain;IPR000198,Rho GTPase-activating protein domain","ENOG410XP6R,-;KOG4637,Adaptor for phosphoinositide 3-kinase","GO:0016301,molecular_function,kinase activity;GO:2001275,biological_process,positive regulation of glucose import in response to insulin stimulus;GO:0043551,biological_process,regulation of phosphatidylinositol 3-kinase activity;GO:0005942,cellular_component,phosphatidylinositol 3-kinase complex;GO:0035014,molecular_function,phosphatidylinositol 3-kinase regulator activity;GO:0016310,biological_process,phosphorylation;GO:0007165,biological_process,signal transduction","-"]
["SLC8A1",1.700631457,0.61281823,1.470179115,4.714004329,{"v":4.51E-6,"d":"4.51E-06"},{"v":1.86e-05,"d":"1.86E-05"},"ENSG00000183023","H2P6E9,Solute carrier family 8 member A1","-","PF01699,Sodium/calcium exchanger protein;PF16494,C-terminal extension of sodium/calcium exchanger domain;PF03160,Calx-beta domain","IPR004837,Sodium/calcium exchanger membrane region;IPR038081,CalX-like domain superfamily;IPR032452,Sodium/calcium exchanger domain, C-terminal extension;IPR001623,DnaJ domain;IPR002987,Sodium/calcium exchanger, isoform 1;IPR004836,Sodium/calcium exchanger protein;IPR003644,Na-Ca exchanger/integrin-beta4","KOG1306,Ca2+/Na+ exchanger NCX1 and related proteins;ENOG410XPJP,-","GO:0006883,biological_process,cellular sodium ion homeostasis;GO:0098735,biological_process,positive regulation of the force of heart contraction;GO:0030506,molecular_function,ankyrin binding;GO:0005432,molecular_function,calcium:sodium antiporter activity;GO:0055085,biological_process,transmembrane transport;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0035994,biological_process,response to muscle stretch;GO:0006816,biological_process,calcium ion transport;GO:0030501,biological_process,positive regulation of bone mineralization;GO:0007154,biological_process,cell communication;GO:0035725,biological_process,sodium ion transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0070509,biological_process,calcium ion import;GO:0098719,biological_process,sodium ion import across plasma membrane;GO:0070588,biological_process,calcium ion transmembrane transport;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["TOB2",20.49491725,7.393063492,1.470081995,6.013216873,{"v":1.42E-8,"d":"1.42E-08"},{"v":1.01E-7,"d":"1.01E-07"},"ENSG00000183864","G3QEI1,Transducer of ERBB2, 2","-","PF07145,Ataxin-2 C-terminal region;PF07742,BTG family","-","-","-","-"]
["GPR107",15.09621889,5.449703868,1.469300685,6.567285639,{"v":1.55E-9,"d":"1.55E-09"},{"v":1.37E-8,"d":"1.37E-08"},"ENSG00000148358","H2R663,G protein-coupled receptor 107","-","PF06814,Lung seven transmembrane receptor","-","-","-","-"]
["CIITA",0.442075703,0.158149632,1.469238326,2.343798945,0.030635115,0.051243208,"ENSG00000179583","A0A087X2I7,MHC class II transactivator","XP_011520794.1,-;NP_001273331.1,MHC class II transactivator isoform 1","PF13516,Leucine Rich repeat;PF05729,NACHT domain","IPR001611,Leucine-rich repeat;IPR007111,NACHT nucleoside triphosphatase;IPR008095,MHC class II transactivator;IPR032675,Leucine-rich repeat domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG4308,LRR-containing protein;ENOG410ZBX3,-","GO:0009986,cellular_component,cell surface;GO:0034341,biological_process,response to interferon-gamma;GO:0071257,biological_process,cellular response to electrical stimulus;GO:0045348,biological_process,positive regulation of MHC class II biosynthetic process;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0071360,biological_process,cellular response to exogenous dsRNA;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0007568,biological_process,aging;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0006954,biological_process,inflammatory response","-"]
["FUZ",2.173364042,0.77750648,1.469238326,2.343798945,0.030635115,0.051243208,"ENSG00000010361","H2QGW3,Uncharacterized protein","XP_001173283.1,-","-","IPR026069,Fuzzy protein","ENOG410ZQFB,-;ENOG410II7D,-","GO:0001843,biological_process,neural tube closure;GO:1905515,biological_process,non-motile cilium assembly;GO:0030336,biological_process,negative regulation of cell migration;GO:0045724,biological_process,positive regulation of cilium assembly","-"]
["ECE2",0.978544555,0.350067783,1.469238326,2.343798945,0.030635115,0.051243208,"ENSG00000145194","F6U0L7,Endothelin converting enzyme 2","-","PF01431,Peptidase family M13;PF05649,Peptidase family M13","IPR008753,Peptidase M13, N-terminal domain;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR018497,Peptidase M13, C-terminal domain;IPR013216,Methyltransferase type 11;IPR000718,Peptidase M13;IPR029733,Endothelin-converting enzyme","KOG3624,M13 family peptidase;COG3590,Predicted metalloendopeptidase","GO:0006508,biological_process,proteolysis;GO:0008152,biological_process,metabolic process;GO:0016486,biological_process,peptide hormone processing;GO:0008237,molecular_function,metallopeptidase activity;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0030659,cellular_component,cytoplasmic vesicle membrane;GO:0016020,cellular_component,membrane;GO:0032259,biological_process,methylation;GO:0016021,cellular_component,integral component of membrane;GO:0008168,molecular_function,methyltransferase activity","-"]
["RAB11FIP3",8.194762019,2.956595911,1.469067569,5.175103223,{"v":4.72e-07,"d":"4.72E-07"},{"v":2.38e-06,"d":"2.38E-06"},"ENSG00000090565","K7D0I6,RAB11 family interacting protein 3","-","PF09457,IP domain","IPR002048,EF-hand domain;IPR032920,Rab11 family-interacting protein 3;IPR019018,Rab-binding domain FIP-RBD;IPR037245,FIP-RBD, C-terminal domain superfamily;IPR011992,EF-hand domain pair","ENOG4111K32,-;KOG0982,Centrosomal protein Nuf","GO:0030306,molecular_function,ADP-ribosylation factor binding;GO:0017137,molecular_function,Rab GTPase binding;GO:0005509,molecular_function,calcium ion binding;GO:0000910,biological_process,cytokinesis;GO:0005622,cellular_component,intracellular;GO:0016192,biological_process,vesicle-mediated transport;GO:0032456,biological_process,endocytic recycling","-"]
["PCDHAC1",2.359894862,0.849480342,1.468702604,3.580219278,0.000430601,0.001127324,"ENSG00000248383","G3S177,Protocadherin alpha subfamily C, 2","XP_018882530.1,protocadherin alpha-C1 isoform X3","PF08266,Cadherin-like;PF00028,Cadherin domain;PF15974,Cadherin C-terminal cytoplasmic tail, catenin-binding region;PF16492,Cadherin cytoplasmic C-terminal","IPR002126,Cadherin;IPR013164,Cadherin, N-terminal;IPR032455,Cadherin, cytoplasmic C-terminal domain;IPR031904,Cadherin, C-terminal catenin-binding domain;IPR015919,Cadherin-like;IPR030742,Protocadherin alpha-C1;IPR020894,Cadherin conserved site","-","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["LZTR1",3.488363701,1.257575424,1.468571795,4.232037586,{"v":4.31e-05,"d":"4.31E-05"},0.000142043,"ENSG00000099949","H2QLA3,Leucine-zipper-like transcription regulator 1","XP_003317159.1,leucine-zipper-like transcriptional regulator 1 isoform X1;XP_016795234.1,-","PF13418,alactose oxidase, central domain;PF07646,Kelch motif;PF00651,BTB/POZ domain;PF01344,Kelch motif","IPR006652,Kelch repeat type 1;IPR000210,BTB/POZ domain;IPR015915,Kelch-type beta propeller;IPR011333,SKP1/BTB/POZ domain superfamily;IPR011498,Kelch repeat type 2","ENOG410Y2DF,-;ENOG410IEDY,-","-","-"]
["TBCE",18.03143627,6.507334774,1.468479104,5.018329717,{"v":1.08E-6,"d":"1.08E-06"},{"v":5.04E-6,"d":"5.04E-06"},"ENSG00000116957","H2RET5,Uncharacterized protein","-","PF01249,Ribosomal protein S21e;PF14560,Ubiquitin-like domain;PF01302,CAP-Gly domain","IPR032675,Leucine-rich repeat domain superfamily;IPR000626,Ubiquitin domain;IPR038579,Ribosomal protein S21e superfamily;IPR000938,CAP Gly-rich domain;IPR036859,CAP Gly-rich domain superfamily;IPR029071,Ubiquitin-like domain superfamily;IPR001931,Ribosomal protein S21e","ENOG410YS3M,-;KOG3207,Beta-tubulin folding cofactor E","GO:0007409,biological_process,axonogenesis;GO:0014889,biological_process,muscle atrophy;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0003735,molecular_function,structural constituent of ribosome;GO:0005622,cellular_component,intracellular;GO:0005840,cellular_component,ribosome;GO:0008344,biological_process,adult locomotory behavior;GO:0048936,biological_process,peripheral nervous system neuron axonogenesis;GO:0007052,biological_process,mitotic spindle organization;GO:0009791,biological_process,post-embryonic development;GO:0048589,biological_process,developmental growth;GO:0006412,biological_process,translation;GO:0007023,biological_process,post-chaperonin tubulin folding pathway","-"]
["APEH",6.611655362,2.386069208,1.467532826,4.451481777,{"v":1.74e-05,"d":"1.74E-05"},{"v":6.3E-5,"d":"6.30E-05"},"ENSG00000164062","C9JIF9,Acylamino-acid-releasing enzyme","-","PF00561,alpha/beta hydrolase fold;PF01738,ienelactone hydrolase family;PF12146,Serine aminopeptidase, S33;PF00326,Prolyl oligopeptidase family","IPR002471,Peptidase S9, serine active site;IPR001375,Peptidase S9, prolyl oligopeptidase, catalytic domain;IPR029058,Alpha/Beta hydrolase fold;IPR011042,Six-bladed beta-propeller, TolB-like","COG1506,Dipeptidyl aminopeptidases/acylaminoacyl-peptidases;KOG2100,Dipeptidyl aminopeptidase","GO:0008236,molecular_function,serine-type peptidase activity;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0006508,biological_process,proteolysis","-"]
["POLDIP3",5.725066516,2.064728558,1.467140536,3.91246307,1.27341E-4,0.000376431,"ENSG00000100227","F6VRR5,Polymerase delta-interacting protein 3","NP_001265586.1,polymerase delta-interacting protein 3 isoform 3","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034784,PDIP3, RNA recognition motif;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034785,Polymerase delta-interacting protein 3;IPR035979,RNA-binding domain superfamily;IPR000504,RNA recognition motif domain","ENOG4111JAW,-;KOG0533,RRM motif-containing protein","GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0016973,biological_process,poly(A)+ mRNA export from nucleus;GO:0003676,molecular_function,nucleic acid binding;GO:0003723,molecular_function,RNA binding;GO:0016607,cellular_component,nuclear speck;GO:0006406,biological_process,mRNA export from nucleus","-"]
["ZBED6",12.79491136,4.625836872,1.466173104,5.245232434,{"v":4.39E-7,"d":"4.39E-07"},{"v":2.23e-06,"d":"2.23E-06"},"ENSG00000257315","K7DIV5,Zinc finger, BED-type containing 6","XP_009439388.1,-","PF02892,BED zinc finger;PF05699,hAT family C-terminal dimerisation region","IPR008906,HAT, C-terminal dimerisation domain;IPR037220,Zinc finger BED domain;IPR003656,Zinc finger, BED-type;IPR036236,Zinc finger C2H2 superfamily;IPR012337,Ribonuclease H-like superfamily","-","GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding","-"]
["RP11-656D10.5",25.28510806,9.101762363,1.466034715,3.036649013,3.497867E-3,0.007447893,"ENSG00000227278","G1SB63,Exonuclease 5","-","PF09810,xonuclease V - a 5' deoxyribonuclease","-","-","-","-"]
["ARPP19",31.27456879,11.32160812,1.465506664,7.212120245,{"v":2.45e-10,"d":"2.45E-10"},{"v":2.57E-9,"d":"2.57E-09"},"ENSG00000128989","H3BMD8,cAMP-regulated phosphoprotein 19","NP_001293125.1,cAMP-regulated phosphoprotein 19 isoform 1;NP_001293120.1,-","PF04667,cAMP-regulated phosphoprotein/endosulfine conserved region","IPR006760,Endosulphine","-","GO:0005737,cellular_component,cytoplasm;GO:0004864,molecular_function,protein phosphatase inhibitor activity;GO:0007212,biological_process,dopamine receptor signaling pathway;GO:0007049,biological_process,cell cycle;GO:0051301,biological_process,cell division;GO:0046579,biological_process,positive regulation of Ras protein signal transduction;GO:0032515,biological_process,negative regulation of phosphoprotein phosphatase activity","-"]
["PDHX",18.06212807,6.535839995,1.46523504,5.559642909,{"v":8.29e-08,"d":"8.29E-08"},{"v":4.96e-07,"d":"4.96E-07"},"ENSG00000110435","G3QFV7,Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex","XP_004050982.1,pyruvate dehydrogenase protein X component, mitochondrial isoform X1","PF00364,Biotin-requiring enzyme;PF02817,e3 binding domain;PF00198,2-oxoacid dehydrogenases acyltransferase (catalytic domain)","IPR036625,E3-binding domain superfamily;IPR011053,Single hybrid motif;IPR004167,Peripheral subunit-binding domain;IPR023213,Chloramphenicol acetyltransferase-like domain superfamily;IPR001078,2-oxoacid dehydrogenase acyltransferase, catalytic domain;IPR000089,Biotin/lipoyl attachment;IPR003016,2-oxo acid dehydrogenase, lipoyl-binding site","-","GO:0045254,cellular_component,pyruvate dehydrogenase complex;GO:0006086,biological_process,acetyl-CoA biosynthetic process from pyruvate;GO:0016740,molecular_function,transferase activity;GO:0034604,molecular_function,pyruvate dehydrogenase (NAD+) activity;GO:0008152,biological_process,metabolic process;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0005739,cellular_component,mitochondrion","K13997,ko00020,Citrate cycle (TCA cycle);K13997,ko00620,Pyruvate metabolism;K13997,ko00010,Glycolysis / Gluconeogenesis"]
["CCDC88C",2.77094166,1.002028884,1.464911029,4.604243468,{"v":6.47e-06,"d":"6.47E-06"},{"v":2.56e-05,"d":"2.56E-05"},"ENSG00000015133","H2Q8S5,Uncharacterized protein","XP_016782089.1,protein Daple isoform X1","PF05622,HOOK protein","IPR008636,Hook-like protein family;IPR027719,Protein Daple;IPR036872,CH domain superfamily","ENOG410YFRJ,-;KOG4643,Uncharacterized coiled-coil protein","GO:0016055,biological_process,Wnt signaling pathway;GO:0031098,biological_process,stress-activated protein kinase signaling cascade;GO:0051959,molecular_function,dynein light intermediate chain binding;GO:0043621,molecular_function,protein self-association;GO:0005737,cellular_component,cytoplasm;GO:0008017,molecular_function,microtubule binding;GO:0030165,molecular_function,PDZ domain binding;GO:0031648,biological_process,protein destabilization;GO:0051260,biological_process,protein homooligomerization;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0031122,biological_process,cytoplasmic microtubule organization;GO:0005813,cellular_component,centrosome;GO:0030705,biological_process,cytoskeleton-dependent intracellular transport","-"]
["ESCO2",1.935897334,0.69864274,1.464701915,3.500232509,0.000770035,1.905608E-3,"ENSG00000171320","H2QVY3,Establishment of cohesion 1 homolog 2","XP_528296.2,N-acetyltransferase ESCO2 isoform X1","PF13878,zinc-finger of acetyl-transferase ESCO;PF13880,SCO1/2 acetyl-transferase","IPR028005,N-acetyltransferase ESCO, zinc-finger;IPR028009,N-acetyltransferase ESCO, acetyl-transferase domain","KOG3014,Protein involved in establishing cohesion between sister chromatids during DNA replication;ENOG410XTJX,-","GO:0005794,cellular_component,Golgi apparatus;GO:0004468,molecular_function,lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0000785,cellular_component,chromatin;GO:0001741,cellular_component,XY body;GO:0034421,biological_process,post-translational protein acetylation;GO:0006275,biological_process,regulation of DNA replication;GO:0030054,cellular_component,cell junction;GO:0031618,cellular_component,nuclear pericentric heterochromatin;GO:0071168,biological_process,protein localization to chromatin;GO:0006302,biological_process,double-strand break repair;GO:0035861,cellular_component,site of double-strand break;GO:0010369,cellular_component,chromocenter;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0007059,biological_process,chromosome segregation;GO:0005634,cellular_component,nucleus","-"]
["SPA17",3.832209837,1.384936752,1.463971531,3.84946331,1.67219E-4,0.000481491,"ENSG00000064199","H2Q513,Sperm surface protein Sp17","XP_003313445.1,-","PF02197,Regulatory subunit of type II PKA R-subunit;PF00612,IQ calmodulin-binding motif","IPR003117,cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain;IPR012105,Sperm surface protein Sp17;IPR000048,IQ motif, EF-hand binding site","ENOG410IX7J,-;ENOG410XXA6,-","GO:0031514,cellular_component,motile cilium;GO:0009897,cellular_component,external side of plasma membrane;GO:0007339,biological_process,binding of sperm to zona pellucida;GO:0005929,cellular_component,cilium;GO:0035686,cellular_component,sperm fibrous sheath;GO:0005737,cellular_component,cytoplasm;GO:0016020,cellular_component,membrane;GO:0097228,cellular_component,sperm principal piece","-"]
["PKD1",1.071939607,0.387392293,1.463971531,3.84946331,1.67219E-4,0.000481491,"ENSG00000008710","F7HI29,Polycystin 1, transient receptor potential channel interacting","-","PF00801,PKD domain","IPR016187,C-type lectin fold;IPR000601,PKD domain;IPR035986,PKD domain superfamily;IPR016186,C-type lectin-like/link domain superfamily;IPR001024,PLAT/LH2 domain;IPR001611,Leucine-rich repeat;IPR036392,PLAT/LH2 domain superfamily;IPR000483,Cysteine-rich flanking region, C-terminal;IPR006228,Polycystin cation channel;IPR000203,GPS motif;IPR013122,Polycystin cation channel, PKD1/PKD2;IPR014010,REJ domain;IPR002859,PKD/REJ-like domain;IPR000372,Leucine-rich repeat N-terminal domain;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily;IPR001304,C-type lectin-like;IPR002889,Carbohydrate-binding WSC;IPR022409,PKD/Chitinase domain;IPR000434,Polycystic kidney disease type 1 protein;IPR013783,Immunoglobulin-like fold","ENOG410XTGE,-;KOG3599,Ca2+-modulated nonselective cation channel polycystin","GO:0030010,biological_process,establishment of cell polarity;GO:0019901,molecular_function,protein kinase binding;GO:0048565,biological_process,digestive tract development;GO:0098609,biological_process,cell-cell adhesion;GO:0060674,biological_process,placenta blood vessel development;GO:0061136,biological_process,regulation of proteasomal protein catabolic process;GO:0005886,cellular_component,plasma membrane;GO:0072164,biological_process,mesonephric tubule development;GO:0009986,cellular_component,cell surface;GO:0048754,biological_process,branching morphogenesis of an epithelial tube;GO:0005634,cellular_component,nucleus;GO:0043588,biological_process,skin development;GO:0072218,biological_process,metanephric ascending thin limb development;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0072001,biological_process,renal system development;GO:0007259,biological_process,JAK-STAT cascade;GO:0007507,biological_process,heart development;GO:0001502,biological_process,cartilage condensation;GO:0005737,cellular_component,cytoplasm;GO:0036303,biological_process,lymph vessel morphogenesis;GO:0006611,biological_process,protein export from nucleus;GO:0042994,biological_process,cytoplasmic sequestering of transcription factor;GO:0072177,biological_process,mesonephric duct development;GO:0072287,biological_process,metanephric distal tubule morphogenesis;GO:0050982,biological_process,detection of mechanical stimulus;GO:0016323,cellular_component,basolateral plasma membrane;GO:0021510,biological_process,spinal cord development;GO:0060236,biological_process,regulation of mitotic spindle organization;GO:0001822,biological_process,kidney development;GO:0006816,biological_process,calcium ion transport;GO:0016021,cellular_component,integral component of membrane;GO:0072237,biological_process,metanephric proximal tubule development;GO:0002133,cellular_component,polycystin complex;GO:0030155,biological_process,regulation of cell adhesion;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0031659,biological_process,positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0016020,cellular_component,membrane;GO:0021915,biological_process,neural tube development;GO:0032092,biological_process,positive regulation of protein binding;GO:0034405,biological_process,response to fluid shear stress;GO:0070588,biological_process,calcium ion transmembrane transport;GO:0070062,cellular_component,extracellular exosome;GO:0005262,molecular_function,calcium channel activity;GO:0007050,biological_process,cell cycle arrest;GO:0001889,biological_process,liver development;GO:0044325,molecular_function,ion channel binding;GO:0005929,cellular_component,cilium;GO:0001892,biological_process,embryonic placenta development;GO:0019904,molecular_function,protein domain specific binding;GO:0031514,cellular_component,motile cilium;GO:0001701,biological_process,in utero embryonic development;GO:0006807,biological_process,nitrogen compound metabolic process;GO:0001568,biological_process,blood vessel development;GO:0060428,biological_process,lung epithelium development;GO:0072205,biological_process,metanephric collecting duct development;GO:0051216,biological_process,cartilage development;GO:0048806,biological_process,genitalia development","-"]
["PBX2",38.92072363,14.10521736,1.463793104,6.85949998,{"v":7.55e-10,"d":"7.55E-10"},{"v":7.12e-09,"d":"7.12E-09"},"ENSG00000204304","H2QSR2,PBX homeobox 2","XP_001163141.1,-","PF03792,PBC domain;PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR005542,PBX","ENOG410XRVF,-;KOG0774,Transcription factor PBX and related HOX domain proteins","GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0009954,biological_process,proximal/distal pattern formation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0008134,molecular_function,transcription factor binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["AC006486.9",38.57791004,13.95412148,1.463510421,4.129892541,{"v":5.65e-05,"d":"5.65E-05"},1.81051E-4,"ENSG00000268643","A0A1D5R791,Uncharacterized protein","-","-","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["ATAD1",9.279082054,3.362640447,1.462531827,5.041284774,{"v":1.09e-06,"d":"1.09E-06"},{"v":5.11e-06,"d":"5.11E-06"},"ENSG00000138138","I3M856,ATPase family, AAA domain containing 1","XP_005339248.1,-","PF00004,ATPase family associated with various cellular activities (AAA)","IPR003959,ATPase, AAA-type, core;IPR003593,AAA+ ATPase domain;IPR003960,ATPase, AAA-type, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0737,AAA+-type ATPase;COG0464,ATPases of the AAA+ class","GO:0045211,cellular_component,postsynaptic membrane;GO:0007612,biological_process,learning;GO:0051967,biological_process,negative regulation of synaptic transmission, glutamatergic;GO:0007613,biological_process,memory;GO:0016887,molecular_function,ATPase activity;GO:0005739,cellular_component,mitochondrion;GO:0002092,biological_process,positive regulation of receptor internalization;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["PHF19",12.34383645,4.477207329,1.462070822,5.846910518,{"v":3.51e-08,"d":"3.51E-08"},{"v":2.3e-07,"d":"2.30E-07"},"ENSG00000119403","A0A087X169,PHD finger protein 19","NP_001273769.1,PHD finger protein 19 isoform c","PF14061,Polycomb-like MTF2 factor 2;PF00628,PHD-finger","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger;IPR025894,Polycomb-like MTF2 factor 2, C-terminal domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR002999,Tudor domain","KOG4323,Polycomb-like PHD Zn-finger protein;ENOG410XQ6E,-","GO:0019827,biological_process,stem cell population maintenance;GO:0048863,biological_process,stem cell differentiation;GO:0046872,molecular_function,metal ion binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0035098,cellular_component,ESC/E(Z) complex;GO:0035064,molecular_function,methylated histone binding;GO:0061087,biological_process,positive regulation of histone H3-K27 methylation","-"]
["MISP",15.53178293,5.634132063,1.461067156,5.01295836,{"v":1.27e-06,"d":"1.27E-06"},{"v":5.87e-06,"d":"5.87E-06"},"ENSG00000099812","H2QET3,Uncharacterized protein","XP_001146667.2,mitotic interactor and substrate of PLK1 isoform X1","PF15304,A-kinase anchor protein 2 C-terminus","IPR029304,A-kinase anchor protein 2, C-terminal domain","ENOG410IP6Q,-;ENOG41127B9,-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005925,cellular_component,focal adhesion;GO:0005886,cellular_component,plasma membrane","-"]
["AACS",1.460703019,0.529343207,1.46068118,4.075948206,{"v":7.23e-05,"d":"7.23E-05"},0.000226237,"ENSG00000081760","A0A024RBV2,Acetoacetyl-CoA synthetase, isoform CRA_b","NP_076417.2,acetoacetyl-CoA synthetase isoform 1","PF00501,AMP-binding enzyme;PF16177,Acetyl-coenzyme A synthetase N-terminus","IPR000873,AMP-dependent synthetase/ligase;IPR005914,Acetoacetyl-CoA synthase;IPR032387,Acetyl-coenzyme A synthetase, N-terminal domain;IPR020845,AMP-binding, conserved site","KOG1175,Acyl-CoA synthetase;COG0365,Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases","GO:0071333,biological_process,cellular response to glucose stimulus;GO:0006629,biological_process,lipid metabolic process;GO:0030729,molecular_function,acetoacetate-CoA ligase activity;GO:0071394,biological_process,cellular response to testosterone stimulus;GO:0032024,biological_process,positive regulation of insulin secretion;GO:0014070,biological_process,response to organic cyclic compound;GO:0042594,biological_process,response to starvation;GO:0003824,molecular_function,catalytic activity;GO:0071397,biological_process,cellular response to cholesterol;GO:0047760,molecular_function,butyrate-CoA ligase activity;GO:0014074,biological_process,response to purine-containing compound;GO:0007584,biological_process,response to nutrient;GO:0010243,biological_process,response to organonitrogen compound;GO:0008152,biological_process,metabolic process;GO:0050872,biological_process,white fat cell differentiation;GO:0005829,cellular_component,cytosol;GO:0060612,biological_process,adipose tissue development;GO:0045471,biological_process,response to ethanol;GO:0001889,biological_process,liver development;GO:0042493,biological_process,response to drug;GO:0034201,biological_process,response to oleic acid","K01907,ko00280,Valine, leucine and isoleucine degradation;K01907,ko00650,Butanoate metabolism"]
["RHPN2",3.954373777,1.432333961,1.460494218,3.783554503,0.000283508,7.77171E-4,"ENSG00000131941","H2QFZ6,Rhophilin, Rho GTPase binding protein 2","XP_016791114.1,rhophilin-2","PF02185,Hr1 repeat;PF03097,BRO1-like domain","IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR038499,BRO1 domain superfamily;IPR036274,HR1 repeat superfamily;IPR004328,BRO1 domain;IPR011072,HR1 rho-binding domain","ENOG410XQX6,-;KOG2220,Predicted signal transduction protein","GO:0007165,biological_process,signal transduction","-"]
["CNOT8",17.22039222,6.253119181,1.460184376,5.555970086,{"v":9.43e-08,"d":"9.43E-08"},{"v":5.56e-07,"d":"5.56E-07"},"ENSG00000155508","A0A091D659,CCR4-NOT transcription complex subunit 8","-","PF04857,CAF1 family ribonuclease","IPR036397,Ribonuclease H superfamily;IPR012337,Ribonuclease H-like superfamily;IPR027212,CCR4-NOT transcription complex subunit 8;IPR006941,Ribonuclease CAF1","-","GO:0003676,molecular_function,nucleic acid binding;GO:0006351,biological_process,transcription, DNA-templated","-"]
["ANKFY1",4.153870813,1.508365717,1.459986793,5.353608278,{"v":3.21e-07,"d":"3.21E-07"},{"v":1.67e-06,"d":"1.67E-06"},"ENSG00000185722","A0A1D5QTD3,Ankyrin repeat and FYVE domain containing 1","-","-","IPR017455,Zinc finger, FYVE-related;IPR011011,Zinc finger, FYVE/PHD-type;IPR000306,FYVE zinc finger;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily;IPR011333,SKP1/BTB/POZ domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR020683,Ankyrin repeat-containing domain;IPR000210,BTB/POZ domain","-","GO:0046872,molecular_function,metal ion binding","-"]
["C11orf95",1.676752875,0.605968039,1.459614894,2.917815479,0.006918611,0.013698475,"ENSG00000188070","A0A096NGZ6,Chromosome 11 open reading frame 95","XP_003909695.1,uncharacterized protein C11orf95 homolog isoform X1","-","IPR013087,Zinc finger C2H2-type","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["LACTB2-AS1",1.829968092,0.661339063,1.459614894,2.917815479,0.006918611,0.013698475,"ENSG00000246366","H2QWA4,Lactamase beta 2","XP_016815054.1,-","PF00753,Metallo-beta-lactamase superfamily","IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR001279,Metallo-beta-lactamase;IPR036388,Winged helix-like DNA-binding domain superfamily","KOG0813,Glyoxylase;COG0491,Zn-dependent hydrolases, including glyoxylases","GO:0003727,molecular_function,single-stranded RNA binding;GO:0004521,molecular_function,endoribonuclease activity;GO:0005759,cellular_component,mitochondrial matrix;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0008270,molecular_function,zinc ion binding;GO:0005739,cellular_component,mitochondrion","-"]
["ADPRM",25.06523756,9.101762363,1.4593286,4.836268869,{"v":3.25e-06,"d":"3.25E-06"},{"v":1.37e-05,"d":"1.37E-05"},"ENSG00000170222","W0NWJ0,Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase","NP_064618.3,manganese-dependent ADP-ribose/CDP-alcohol diphosphatase","PF00149,Calcineurin-like phosphoesterase","IPR029052,Metallo-dependent phosphatase-like;IPR004843,Calcineurin-like phosphoesterase domain, ApaH type","ENOG410IJ2N,-;COG1409,Predicted phosphohydrolases","GO:0016787,molecular_function,hydrolase activity","K01517,ko00230,Purine metabolism;K01517,ko00564,Glycerophospholipid metabolism"]
["RP11-48C7.8",153.5912429,55.77250129,1.459061393,4.671515717,{"v":6.51e-06,"d":"6.51E-06"},{"v":2.58E-5,"d":"2.58E-05"},"ENSG00000283411","U3D174,Arrestin domain-containing protein 1","-","PF00339,Arrestin (or S-antigen), N-terminal domain;PF02752,Arrestin (or S-antigen), C-terminal domain","IPR011022,Arrestin C-terminal-like domain;IPR014752,Arrestin, C-terminal;IPR011021,Arrestin-like, N-terminal;IPR014756,Immunoglobulin E-set","KOG3780,Thioredoxin binding protein TBP-2/VDUP1;ENOG41102NY,-","GO:0007165,biological_process,signal transduction","-"]
["CHD5",0.552232896,0.198784699,1.458093727,2.144382194,0.027678904,0.046701259,"ENSG00000116254","H9ETJ8,Chromodomain-helicase-DNA-binding protein 5","-","PF08074,CHDCT2 (NUC038) domain;PF00628,PHD-finger;PF00271,Helicase conserved C-terminal domain;PF08073,CHDNT (NUC034) domain;PF00176,SNF2 family N-terminal domain;PF06465,omain of Unknown Function (DUF1087);PF06461,omain of Unknown Function (DUF1086);PF00385,Chromo (CHRromatin Organisation MOdifier) domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR023780,Chromo domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR009463,Domain of unknown function DUF1087;IPR016197,Chromo-like domain superfamily;IPR012957,CHD, C-terminal 2;IPR009462,Domain of unknown function DUF1086;IPR012958,CHD, N-terminal;IPR028727,Chromodomain-helicase-DNA-binding protein 5;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger;IPR000953,Chromo/chromo shadow domain;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR019786,Zinc finger, PHD-type, conserved site;IPR001650,Helicase, C-terminal","COG0553,Superfamily II DNA/RNA helicases, SNF2 family;KOG0383,Predicted helicase","GO:0004386,molecular_function,helicase activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0005524,molecular_function,ATP binding","-"]
["SYDE2",0.846625847,0.304755956,1.458093727,2.144382194,0.027678904,0.046701259,"ENSG00000097096","G3QK10,Synapse defective Rho GTPase homolog 2","XP_004026111.2,rho GTPase-activating protein SYDE2","PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain;IPR035892,C2 domain superfamily","-","GO:0007165,biological_process,signal transduction","-"]
["SORCS2",0.864584984,0.311220622,1.458093727,2.144382194,0.027678904,0.046701259,"ENSG00000184985","G3RID4,Sortilin related VPS10 domain containing receptor 2","XP_018880544.1,VPS10 domain-containing receptor SorCS2, partial","PF00801,PKD domain;PF15902,Sortilin, neurotensin receptor 3,;PF15901,Sortilin, neurotensin receptor 3, C-terminal","IPR000601,PKD domain;IPR035986,PKD domain superfamily;IPR006581,VPS10;IPR031777,Sortilin, C-terminal;IPR031778,Sortilin, N-terminal;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR013783,Immunoglobulin-like fold;IPR022409,PKD/Chitinase domain","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MAP7D3",17.84227213,6.491139424,1.458067362,6.441675302,{"v":3.07e-09,"d":"3.07E-09"},{"v":2.53e-08,"d":"2.53E-08"},"ENSG00000129680","K7BDY9,MAP7 domain containing 3","XP_016799745.1,MAP7 domain-containing protein 3 isoform X1;XP_016799746.1,-","PF05672,MAP7 (E-MAP-115) family","IPR008604,Microtubule-associated protein 7 family","-","GO:0046785,biological_process,microtubule polymerization;GO:0008017,molecular_function,microtubule binding;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0015631,molecular_function,tubulin binding","-"]
["ARHGEF12",7.745380907,2.819592012,1.457390963,7.020862798,{"v":5.25e-10,"d":"5.25E-10"},{"v":5.17e-09,"d":"5.17E-09"},"ENSG00000196914","H2RD37,Rho guanine nucleotide exchange factor","XP_016777644.1,rho guanine nucleotide exchange factor 12 isoform X1","PF00621,RhoGEF domain;PF00595,PDZ domain (Also known as DHR or GLGF);PF09128,Regulator of G protein signalling-like domain","IPR001331,Guanine-nucleotide dissociation stimulator, CDC24, conserved site;IPR015212,Regulator of G protein signalling-like domain;IPR001478,PDZ domain;IPR036305,RGS domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR035899,Dbl homology (DH) domain superfamily;IPR036034,PDZ superfamily;IPR037884,LARG, RGS domain;IPR000219,Dbl homology (DH) domain;IPR037801,ARHGEF12, PH domain","COG5422,RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases;KOG3520,Predicted guanine nucleotide exchange factor","GO:0001664,molecular_function,G-protein coupled receptor binding;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0065009,biological_process,regulation of molecular function;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0007266,biological_process,Rho protein signal transduction;GO:0005096,molecular_function,GTPase activator activity;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","K07532,ko05205,Proteoglycans in cancer;K07532,ko04810,Regulation of actin cytoskeleton;K07532,ko04360,Axon guidance;K07532,ko05152,Tuberculosis;K07532,ko04611,Platelet activation;K07532,ko04270,Vascular smooth muscle contraction;K07532,ko05200,Pathways in cancer"]
["FAM234A",10.15737161,3.695714533,1.456785289,5.063880558,{"v":9.43e-07,"d":"9.43E-07"},{"v":4.47e-06,"d":"4.47E-06"},"ENSG00000167930","K6ZVX1,Integrin alpha FG-GAP repeat containing 3","-","-","-","-","-","-"]
["SEPP1",6.804852968,2.477061909,1.45569628,4.770064924,{"v":3.8E-6,"d":"3.80E-06"},{"v":1.59E-5,"d":"1.59E-05"},"ENSG00000250722","A0A182DWH7,Selenoprotein P","-","PF04593,Selenoprotein P, C terminal region;PF04592,Selenoprotein P, N terminal region","IPR007671,Selenoprotein P, N-terminal;IPR007672,Selenoprotein P, C-terminal;IPR037941,Selenoprotein P","-","GO:0008430,molecular_function,selenium binding","-"]
["ITSN1",12.52376249,4.565110532,1.455628581,7.545200776,1.36E-10,{"v":1.5E-9,"d":"1.50E-09"},"ENSG00000205726","H2RAJ0,Uncharacterized protein","-","PF16652,Pleckstrin homology domain;PF00621,RhoGEF domain;PF12763,Cytoskeletal-regulatory complex EF hand;PF14604,Variant SH3 domain;PF00018,SH3 domain;PF16617,Intersectin and clathrin adaptor AP2 binding region;PF00168,C2 domain","IPR018247,EF-Hand 1, calcium-binding site;IPR001331,Guanine-nucleotide dissociation stimulator, CDC24, conserved site;IPR035899,Dbl homology (DH) domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR002048,EF-hand domain;IPR036028,SH3-like domain superfamily;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR011992,EF-hand domain pair;IPR001452,SH3 domain;IPR000261,EH domain;IPR000219,Dbl homology (DH) domain","COG5422,RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases;KOG1029,Endocytic adaptor protein intersectin;KOG4305,RhoGEF GTPase","GO:0005509,molecular_function,calcium ion binding;GO:0035556,biological_process,intracellular signal transduction;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005622,cellular_component,intracellular;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","-"]
["SORT1",3.732997917,1.359302501,1.454936946,4.597049892,{"v":7.84e-06,"d":"7.84E-06"},{"v":3.05e-05,"d":"3.05E-05"},"ENSG00000134243","K7D492,Sortilin","XP_016779462.1,sortilin isoform X1","PF15902,Sortilin, neurotensin receptor 3,;PF15901,Sortilin, neurotensin receptor 3, C-terminal","IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR031778,Sortilin, N-terminal;IPR031777,Sortilin, C-terminal;IPR006581,VPS10","ENOG410ISX8,-;ENOG410ZJ6Q,-","GO:0016020,cellular_component,membrane;GO:0032868,biological_process,response to insulin;GO:0038180,biological_process,nerve growth factor signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0005769,cellular_component,early endosome;GO:0030659,cellular_component,cytoplasmic vesicle membrane;GO:0051005,biological_process,negative regulation of lipoprotein lipase activity;GO:0046323,biological_process,glucose import;GO:0032509,biological_process,endosome transport via multivesicular body sorting pathway;GO:0005794,cellular_component,Golgi apparatus;GO:0010465,molecular_function,nerve growth factor receptor activity;GO:0045599,biological_process,negative regulation of fat cell differentiation;GO:0007218,biological_process,neuropeptide signaling pathway;GO:0008333,biological_process,endosome to lysosome transport;GO:0005829,cellular_component,cytosol;GO:0048406,molecular_function,nerve growth factor binding;GO:0016021,cellular_component,integral component of membrane;GO:0048011,biological_process,neurotrophin TRK receptor signaling pathway;GO:0006895,biological_process,Golgi to endosome transport;GO:0016050,biological_process,vesicle organization;GO:0005905,cellular_component,clathrin-coated pit;GO:0009986,cellular_component,cell surface;GO:0014902,biological_process,myotube differentiation;GO:0048227,biological_process,plasma membrane to endosome transport;GO:0010468,biological_process,regulation of gene expression;GO:0030136,cellular_component,clathrin-coated vesicle;GO:0019899,molecular_function,enzyme binding;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0008625,biological_process,extrinsic apoptotic signaling pathway via death domain receptors;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0030379,molecular_function,neurotensin receptor activity, non-G-protein coupled;GO:0030140,cellular_component,trans-Golgi network transport vesicle;GO:0006897,biological_process,endocytosis","K12388,ko04142,Lysosome;K12388,ko04722,Neurotrophin signaling pathway"]
["KLC4",3.365343906,1.224719309,1.454298126,3.961540298,{"v":9.76e-05,"d":"9.76E-05"},0.000295962,"ENSG00000137171","H2QT19,Uncharacterized protein","XP_001135427.2,-;XP_016811033.1,-;XP_009449556.1,-","PF13374,Tetratricopeptide repeat;PF13424,Tetratricopeptide repeat","IPR015792,Kinesin light chain repeat;IPR002151,Kinesin light chain;IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR011990,Tetratricopeptide-like helical domain superfamily","KOG1840,Kinesin light chain;COG0457,FOG: TPR repeat","GO:0005871,cellular_component,kinesin complex;GO:0003777,molecular_function,microtubule motor activity","-"]
["ACOT7",13.0706724,4.767169424,1.453525844,5.236058977,{"v":5.9e-07,"d":"5.90E-07"},{"v":2.93e-06,"d":"2.93E-06"},"ENSG00000097021","H2PXW7,Acyl-CoA thioesterase 7","XP_001156114.1,cytosolic acyl coenzyme A thioester hydrolase isoform X1","PF03061,Thioesterase superfamily","IPR033120,Hotdog acyl-CoA thioesterase (ACOT)-type domain;IPR006683,Thioesterase domain;IPR029069,HotDog domain superfamily","COG1607,Acyl-CoA hydrolase;KOG2763,Acyl-CoA thioesterase","GO:0006631,biological_process,fatty acid metabolic process;GO:0006637,biological_process,acyl-CoA metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0005829,cellular_component,cytosol;GO:0047617,molecular_function,acyl-CoA hydrolase activity","-"]
["USP32",7.410103824,2.704121275,1.452831722,5.326542206,{"v":3.08e-07,"d":"3.08E-07"},{"v":1.62e-06,"d":"1.62E-06"},"ENSG00000170832","H2QDL0,Ubiquitin specific peptidase 32","-","PF14836,Ubiquitin-like domain;PF06337,USP domain;PF00443,Ubiquitin carboxyl-terminal hydrolase;PF13202,hand","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","COG5560,Ubiquitin C-terminal hydrolase;KOG1870,Ubiquitin C-terminal hydrolase;KOG0044,Ca2+ sensor (EF-Hand superfamily)","GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016579,biological_process,protein deubiquitination","-"]
["RP1-317E23.6",11.3932898,4.137164711,1.451886658,2.788094216,0.006071182,0.012203788,"ENSG00000255054","H3BT81,Uncharacterized protein","-","-","-","-","-","-"]
["AC000068.10",19.61627287,7.123118371,1.451886658,2.788094216,0.006071182,0.012203788,"-","-","-","-","-","-","-","-"]
["MTMR9",1.024930205,0.372175653,1.451886658,2.788094216,0.006071182,0.012203788,"ENSG00000104643","H2R5W3,Myotubularin related protein 9","XP_001138621.1,-","PF06602,Myotubularin-like phosphatase domain","IPR030564,Myotubularin family;IPR029021,Protein-tyrosine phosphatase-like;IPR011993,PH-like domain superfamily;IPR010569,Myotubularin-like phosphatase domain","ENOG410XPTU,-;KOG1089,Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6","GO:0050821,biological_process,protein stabilization;GO:0060304,biological_process,regulation of phosphatidylinositol dephosphorylation;GO:0010922,biological_process,positive regulation of phosphatase activity;GO:0032991,cellular_component,protein-containing complex;GO:0005737,cellular_component,cytoplasm;GO:0030234,molecular_function,enzyme regulator activity;GO:0019903,molecular_function,protein phosphatase binding;GO:0010507,biological_process,negative regulation of autophagy","-"]
["DCTD",10.61925058,3.875995744,1.451699942,4.700659411,{"v":5.42e-06,"d":"5.42E-06"},{"v":2.19E-5,"d":"2.19E-05"},"ENSG00000129187","K6ZVZ8,dCMP deaminase","XP_016808038.1,-","PF00383,Cytidine and deoxycytidylate deaminase zinc-binding region","IPR016193,Cytidine deaminase-like;IPR035105,Deoxycytidylate deaminase domain;IPR002125,Cytidine and deoxycytidylate deaminase domain;IPR016192,APOBEC/CMP deaminase, zinc-binding;IPR016473,Deoxycytidylate deaminase;IPR015517,Deoxycytidylate deaminase-related","COG2131,Deoxycytidylate deaminase;KOG3127,Deoxycytidylate deaminase","GO:0016787,molecular_function,hydrolase activity;GO:0006220,biological_process,pyrimidine nucleotide metabolic process;GO:0003824,molecular_function,catalytic activity;GO:0046872,molecular_function,metal ion binding;GO:0042802,molecular_function,identical protein binding;GO:0008270,molecular_function,zinc ion binding;GO:0004132,molecular_function,dCMP deaminase activity","-"]
["TMEM8A",6.461137301,2.357821057,1.4513329,4.355768007,{"v":2.7e-05,"d":"2.70E-05"},{"v":9.32e-05,"d":"9.32E-05"},"ENSG00000129925","K7B2S0,Transmembrane protein 8A","XP_016784488.1,transmembrane protein 8A isoform X1","PF12036,Protein of unknown function (DUF3522)","IPR013032,EGF-like, conserved site;IPR021910,NGX6/PGAP6/MYMK;IPR000742,EGF-like domain","ENOG4111FA8,-;ENOG410IHJ3,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZXDC",2.80807838,1.024365806,1.450679683,3.900706978,0.000162185,4.68758E-4,"ENSG00000070476","K7CDL2,ZXD family zinc finger C","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["TBC1D9B",19.82801527,7.254119677,1.450289558,7.28825655,{"v":2.77e-10,"d":"2.77E-10"},{"v":2.88E-9,"d":"2.88E-09"},"ENSG00000197226","B9A6K8,TBC1 domain family, member 9B","-","PF00566,Rab-GTPase-TBC domain;PF02893,RAM domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR004182,GRAM domain;IPR000195,Rab-GTPase-TBC domain;IPR036017,TCB1D9/TCB1D9B, PH-GRAM domain 2;IPR011993,PH-like domain superfamily;IPR002048,EF-hand domain;IPR036014,TCB1D9/TCB1D9B, PH-GRAM domain 1;IPR011992,EF-hand domain pair","COG5210,GTPase-activating protein;KOG4347,GTPase-activating protein VRP","GO:0005509,molecular_function,calcium ion binding","-"]
["DDR1",19.13321714,7.004425761,1.449248301,6.908824967,{"v":8.53e-10,"d":"8.53E-10"},{"v":7.96e-09,"d":"7.96E-09"},"ENSG00000204580","A0A024RCJ0,Discoidin domain receptor family, member 1, isoform CRA_b","XP_011513189.1,-;XP_011513185.1,-;XP_011513188.1,-;XP_016866757.1,-;XP_011513186.1,-;XP_011513187.1,-;NP_054700.2,epithelial discoidin domain-containing receptor 1 isoform 3 precursor","PF00754,5/8 type C domain;PF07714,Protein tyrosine kinase","IPR000421,Coagulation factor 5/8 C-terminal domain;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR029553,Epithelial discoidin domain-containing receptor 1;IPR011009,Protein kinase-like domain superfamily;IPR002011,Tyrosine-protein kinase, receptor class II, conserved site;IPR008266,Tyrosine-protein kinase, active site;IPR008979,Galactose-binding-like domain superfamily;IPR000719,Protein kinase domain","KOG1094,Discoidin domain receptor DDR1;ENOG410XQAI,-","GO:0038083,biological_process,peptidyl-tyrosine autophosphorylation;GO:0005518,molecular_function,collagen binding;GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding;GO:0001558,biological_process,regulation of cell growth;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0044319,biological_process,wound healing, spreading of cells;GO:0014909,biological_process,smooth muscle cell migration;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:1990138,biological_process,neuron projection extension;GO:0060444,biological_process,branching involved in mammary gland duct morphogenesis;GO:0038062,molecular_function,protein tyrosine kinase collagen receptor activity;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0061302,biological_process,smooth muscle cell-matrix adhesion;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0016020,cellular_component,membrane;GO:0060749,biological_process,mammary gland alveolus development;GO:0006468,biological_process,protein phosphorylation;GO:0001952,biological_process,regulation of cell-matrix adhesion;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0004714,molecular_function,transmembrane receptor protein tyrosine kinase activity;GO:0046777,biological_process,protein autophosphorylation;GO:0007566,biological_process,embryo implantation;GO:0043583,biological_process,ear development;GO:0038063,biological_process,collagen-activated tyrosine kinase receptor signaling pathway;GO:0061564,biological_process,axon development;GO:0010715,biological_process,regulation of extracellular matrix disassembly","-"]
["LETMD1",2.086436953,0.760492081,1.449191767,3.229139492,1.691433E-3,0.003889716,"ENSG00000050426","G7PIB1,Uncharacterized protein","-","PF07766,LETM1-like protein","IPR033122,Letm1 ribosome-binding domain;IPR011685,LETM1-like","-","GO:0043022,molecular_function,ribosome binding;GO:0005739,cellular_component,mitochondrion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GRB7",8.714133772,3.188273722,1.447841579,4.4775579,{"v":1.73E-5,"d":"1.73E-05"},{"v":6.27e-05,"d":"6.27E-05"},"ENSG00000141738","H2QCV3,Uncharacterized protein","XP_009430535.2,-;XP_016787370.1,-","PF00788,Ras association (RalGDS/AF-6) domain;PF08947,BPS (Between PH and SH2);PF00017,SH2 domain;PF00169,PH domain","IPR036860,SH2 domain superfamily;IPR000159,Ras-associating (RA) domain;IPR035032,Growth factor receptor-bound protein 7;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR015042,BPS (Between PH and SH2) domain;IPR029071,Ubiquitin-like domain superfamily;IPR000980,SH2 domain","ENOG410XXC8,-;KOG3751,Growth factor receptor-bound proteins (GRB7, GRB10, GRB14)","GO:0007165,biological_process,signal transduction;GO:0005070,molecular_function,SH3/SH2 adaptor activity;GO:0009967,biological_process,positive regulation of signal transduction","-"]
["SERPINB1",5.218904292,1.906251458,1.447685464,3.565310344,0.000561363,1.436023E-3,"ENSG00000021355","V9HWH1,Epididymis luminal protein 57","XP_011512635.1,-;NP_109591.1,leukocyte elastase inhibitor;XP_011512636.1,-","PF00079,Serpin (serine protease inhibitor)","IPR023795,Serpin, conserved site;IPR023796,Serpin domain;IPR015557,Leukocyte elastase inhibitor (serpin B1);IPR036186,Serpin superfamily;IPR000215,Serpin family","KOG2392,Serpin;COG4826,Serine protease inhibitor","GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0004867,molecular_function,serine-type endopeptidase inhibitor activity;GO:0005615,cellular_component,extracellular space","K13963,ko05146,Amoebiasis"]
["THAP5",3.254845773,1.188861522,1.447685464,3.565310344,0.000561363,1.436023E-3,"ENSG00000177683","H2QV87,THAP domain containing 5","-","PF05485,THAP domain","IPR038441,THAP-type zinc finger superfamily;IPR006612,THAP-type zinc finger","ENOG4111Z0Y,-;ENOG410IE4G,-","GO:0003676,molecular_function,nucleic acid binding;GO:0003677,molecular_function,DNA binding","-"]
["ZNF652",13.3958788,4.909372843,1.447451628,6.349999861,{"v":5.91e-09,"d":"5.91E-09"},{"v":4.58E-8,"d":"4.58E-08"},"ENSG00000198740","H2NVK7,Zinc finger protein 652","XP_009234861.1,zinc finger protein 652","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["ORC3",5.342692344,1.954078556,1.446723482,3.837166241,0.000213665,0.000601875,"ENSG00000135336","H2QTD6,Origin recognition complex, subunit 3","XP_009449896.1,origin recognition complex subunit 3 isoform X1","PF07034,Origin recognition complex (ORC) subunit 3 N-terminus","IPR020795,Origin recognition complex, subunit 3","ENOG410XT1W,-;KOG2538,Origin recognition complex, subunit 3","GO:0003677,molecular_function,DNA binding;GO:0005664,cellular_component,nuclear origin of replication recognition complex;GO:0006270,biological_process,DNA replication initiation;GO:0005656,cellular_component,nuclear pre-replicative complex;GO:0006260,biological_process,DNA replication;GO:0000784,cellular_component,nuclear chromosome, telomeric region;GO:0031261,cellular_component,DNA replication preinitiation complex;GO:0006267,biological_process,pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0000808,cellular_component,origin recognition complex;GO:0003688,molecular_function,DNA replication origin binding;GO:0016604,cellular_component,nuclear body;GO:0005654,cellular_component,nucleoplasm","K02605,ko04111,Cell cycle - yeast;K02605,ko04113,Meiosis - yeast;K02605,ko04110,Cell cycle"]
["DOCK6",3.380011718,1.238454517,1.446447444,4.88784979,{"v":2.77e-06,"d":"2.77E-06"},{"v":1.19E-5,"d":"1.19E-05"},"ENSG00000130158","G3R274,Dedicator of cytokinesis 6","-","PF06920,ock homology region 2;PF14429,C2 domain in Dock180 and Zizimin proteins;PF11878,omain of unknown function (DUF3398)","IPR027007,DHR-1 domain;IPR010703,Dedicator of cytokinesis, C-terminal;IPR026798,Dedicator of cytokinesis 6;IPR035892,C2 domain superfamily;IPR021816,Dedicator of cytokinesis C/D, N-terminal;IPR037808,Dedicator of cytokinesis C, C2 domain;IPR027357,DHR-2 domain;IPR026791,Dedicator of cytokinesis","-","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component,intracellular;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0065009,biological_process,regulation of molecular function","-"]
["ARFGEF3",1.564232993,0.572645666,1.446055927,4.065484339,{"v":9.09E-5,"d":"9.09E-05"},0.000276482,"ENSG00000112379","H2QTT7,Uncharacterized protein","XP_518767.2,brefeldin A-inhibited guanine nucleotide-exchange protein 3 isoform X1","PF09324,omain of unknown function (DUF1981);PF16213,imerisation and cyclophilin-binding domain of Mon2","IPR016024,Armadillo-type fold;IPR032629,Mon2, dimerisation and cyclophilin-binding domain;IPR015403,Sec7, C-terminal;IPR000904,Sec7 domain","KOG1846,Uncharacterized conserved protein, contains Sec7 domain;ENOG410XNND,-","GO:0032012,biological_process,regulation of ARF protein signal transduction;GO:0005086,molecular_function,ARF guanyl-nucleotide exchange factor activity;GO:0010923,biological_process,negative regulation of phosphatase activity","-"]
["ARAF",8.598274002,3.151501311,1.44519012,4.435406344,{"v":1.76e-05,"d":"1.76E-05"},{"v":6.34e-05,"d":"6.34E-05"},"ENSG00000078061","G3R027,A-Raf proto-oncogene, serine/threonine kinase","XP_004064129.2,-","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF02196,Raf-like Ras-binding domain;PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR020454,Diacylglycerol/phorbol-ester binding;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR003116,Raf-like Ras-binding;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR029071,Ubiquitin-like domain superfamily;IPR000719,Protein kinase domain","-","GO:0016301,molecular_function,kinase activity;GO:0005057,molecular_function,signal transducer activity, downstream of receptor;GO:0035556,biological_process,intracellular signal transduction;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0016310,biological_process,phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005622,cellular_component,intracellular;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0007165,biological_process,signal transduction;GO:0004672,molecular_function,protein kinase activity","-"]
["RNF34",7.950562186,2.916267153,1.44465306,4.729225997,{"v":5.44e-06,"d":"5.44E-06"},{"v":2.19E-5,"d":"2.19E-05"},"ENSG00000170633","H7BYJ1,E3 ubiquitin-protein ligase RNF34","-","PF13920,Zinc finger, C3HC4 type (RING finger)","IPR036361,SAP domain superfamily;IPR011011,Zinc finger, FYVE/PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410IMEF,-;ENOG410Y1GP,-","GO:0016604,cellular_component,nuclear body;GO:0046872,molecular_function,metal ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["EPS15L1",5.295042974,1.943206293,1.444287385,4.97303518,{"v":2.05e-06,"d":"2.05E-06"},{"v":9.07e-06,"d":"9.07E-06"},"ENSG00000127527","H2NXY2,Epidermal growth factor receptor pathway substrate 15 like 1","XP_002828907.1,epidermal growth factor receptor substrate 15-like 1 isoform X2","PF12763,Cytoskeletal-regulatory complex EF hand","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR003903,Ubiquitin interacting motif;IPR000261,EH domain;IPR011992,EF-hand domain pair","KOG0998,Synaptic vesicle protein EHS-1 and related EH domain proteins;ENOG410XTDR,-","GO:0005509,molecular_function,calcium ion binding","K12472,ko04144,Endocytosis"]
["DUSP3",12.46049845,4.576305099,1.44373815,5.446478576,{"v":2.05E-7,"d":"2.05E-07"},{"v":1.13E-6,"d":"1.13E-06"},"ENSG00000108861","A0A0D9S155,Dual specificity phosphatase 3","XP_008010705.1,-","PF00782,ual specificity phosphatase, catalytic domain","IPR029021,Protein-tyrosine phosphatase-like;IPR016130,Protein-tyrosine phosphatase, active site;IPR000340,Dual specificity phosphatase, catalytic domain;IPR020405,Atypical dual specificity phosphatase, subfamily A;IPR020422,Dual specificity protein phosphatase domain;IPR000387,Tyrosine specific protein phosphatases domain;IPR020417,Atypical dual specificity phosphatase;IPR024950,Dual specificity phosphatase","-","GO:0046329,biological_process,negative regulation of JNK cascade;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:0050868,biological_process,negative regulation of T cell activation;GO:0000188,biological_process,inactivation of MAPK activity;GO:0001772,cellular_component,immunological synapse;GO:0033549,molecular_function,MAP kinase phosphatase activity;GO:0043409,biological_process,negative regulation of MAPK cascade;GO:0006470,biological_process,protein dephosphorylation;GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0005654,cellular_component,nucleoplasm;GO:0005829,cellular_component,cytosol;GO:0019901,molecular_function,protein kinase binding;GO:0016311,biological_process,dephosphorylation;GO:0050860,biological_process,negative regulation of T cell receptor signaling pathway;GO:0045931,biological_process,positive regulation of mitotic cell cycle;GO:0005634,cellular_component,nucleus;GO:0016791,molecular_function,phosphatase activity","K17614,ko04010,MAPK signaling pathway"]
["ACTR6",1.183252756,0.429666201,1.442438318,1.91203868,0.045280597,0.071892328,"ENSG00000075089","I3M525,ARP6 actin related protein 6 homolog","XP_005322436.1,-","PF00022,Actin","IPR030054,Actin-related protein 6;IPR004000,Actin family","ENOG410XPT5,-;KOG0680,Actin-related protein - Arp6p","GO:0005634,cellular_component,nucleus;GO:0006338,biological_process,chromatin remodeling","-"]
["ZNF2",1.129064755,0.409989296,1.442438318,1.91203868,0.045280597,0.071892328,"ENSG00000275111","A0A087WYR5,Zinc finger protein 2","NP_001278534.1,zinc finger protein 2 isoform e","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["DPYSL3",0.629779838,0.228687497,1.442438318,1.91203868,0.045280597,0.071892328,"ENSG00000113657","K7B2Z5,Dihydropyrimidinase-like 3","XP_016809498.1,-","PF01979,Amidohydrolase family","IPR011778,Hydantoinase/dihydropyrimidinase;IPR006680,Amidohydrolase-related;IPR032466,Metal-dependent hydrolase;IPR011059,Metal-dependent hydrolase, composite domain superfamily;IPR030628,Dihydropyrimidinase-related protein 3","KOG2584,Dihydroorotase and related enzymes;COG0044,Dihydroorotase and related cyclic amidohydrolases","GO:0030334,biological_process,regulation of cell migration;GO:0016787,molecular_function,hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0010975,biological_process,regulation of neuron projection development;GO:0016810,molecular_function,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0051017,biological_process,actin filament bundle assembly;GO:0051491,biological_process,positive regulation of filopodium assembly;GO:0048678,biological_process,response to axon injury;GO:0031005,molecular_function,filamin binding","-"]
["PTPRE",0.718615482,0.26248073,1.442404466,2.645271485,0.009165782,0.01761884,"ENSG00000132334","H2R3E7,Receptor-type tyrosine-protein phosphatase","XP_016775112.1,-;XP_009457783.1,-;XP_003312873.1,receptor-type tyrosine-protein phosphatase epsilon isoform X1;XP_016775114.1,-;XP_016775115.1,-;XP_016775113.1,-","PF00102,Protein-tyrosine phosphatase","IPR016336,Receptor tyrosine-protein phosphatase, alpha/epsilon-type;IPR000242,PTP type protein phosphatase;IPR029021,Protein-tyrosine phosphatase-like;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR000387,Tyrosine specific protein phosphatases domain;IPR016130,Protein-tyrosine phosphatase, active site","COG5599,Protein tyrosine phosphatase;KOG4228,Protein tyrosine phosphatase","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0006470,biological_process,protein dephosphorylation;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016311,biological_process,dephosphorylation;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane;GO:0016791,molecular_function,phosphatase activity","-"]
["NOD1",1.183818906,0.432400441,1.442404466,2.645271485,0.009165782,0.01761884,"ENSG00000106100","A0A024RA73,Caspase recruitment domain family, member 4","XP_011513382.1,-;XP_005249625.1,-;XP_006715696.1,-;XP_005249629.1,-;XP_011513381.1,-;NP_006083.1,nucleotide-binding oligomerization domain-containing protein 1 isoform 1;XP_011513383.1,-","PF00619,Caspase recruitment domain;PF13516,Leucine Rich repeat;PF05729,NACHT domain","IPR001611,Leucine-rich repeat;IPR007111,NACHT nucleoside triphosphatase;IPR001315,CARD domain;IPR011029,Death-like domain superfamily;IPR032675,Leucine-rich repeat domain superfamily","KOG4308,LRR-containing protein;ENOG410ZBX3,-","GO:0050830,biological_process,defense response to Gram-positive bacterium;GO:0010942,biological_process,positive regulation of cell death;GO:0032874,biological_process,positive regulation of stress-activated MAPK cascade;GO:0042981,biological_process,regulation of apoptotic process;GO:0000166,molecular_function,nucleotide binding;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:1904417,biological_process,positive regulation of xenophagy;GO:0002606,biological_process,positive regulation of dendritic cell antigen processing and presentation;GO:0032760,biological_process,positive regulation of tumor necrosis factor production;GO:0005524,molecular_function,ATP binding;GO:0032731,biological_process,positive regulation of interleukin-1 beta production;GO:0032755,biological_process,positive regulation of interleukin-6 production;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0051000,biological_process,positive regulation of nitric-oxide synthase activity;GO:0046330,biological_process,positive regulation of JNK cascade","K08727,ko04621,NOD-like receptor signaling pathway;K08727,ko05133,Pertussis;K08727,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K08727,ko05131,Shigellosis"]
["RP11-136L23.2",35.47422902,12.98666093,1.442391278,3.125920087,0.003238274,0.006933681,"-","-","-","-","-","-","-","-"]
["GRTP1",3.990242496,1.460776676,1.442391278,3.125920087,0.003238274,0.006933681,"ENSG00000139835","B4DV24,cDNA FLJ55860, highly similar to Homo sapiens growth hormone regulated TBC protein 1","-","PF00566,Rab-GTPase-TBC domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain","COG5210,GTPase-activating protein;KOG2058,Ypt/Rab GTPase activating protein","-","-"]
["DARS2",5.085213195,1.865256803,1.4423799,3.770664211,0.00036304,0.000970016,"ENSG00000117593","A0A024R8Z9,Aspartyl-tRNA synthetase 2","NP_060592.2,aspartate--tRNA ligase, mitochondrial","PF02938,AD domain;PF00152,tRNA synthetases class II (D, K and N);PF01336,OB-fold nucleic acid binding domain","IPR004364,Aminoacyl-tRNA synthetase, class II (D/K/N);IPR004365,OB-fold nucleic acid binding domain, AA-tRNA synthetase-type;IPR004524,Aspartate-tRNA ligase, type 1;IPR004115,GAD-like domain superfamily;IPR029351,GAD domain;IPR006195,Aminoacyl-tRNA synthetase, class II;IPR002312,Aspartyl/Asparaginyl-tRNA synthetase, class IIb;IPR012340,Nucleic acid-binding, OB-fold","COG0173,Aspartyl-tRNA synthetase;KOG2411,Aspartyl-tRNA synthetase, mitochondrial","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0005524,molecular_function,ATP binding;GO:0016874,molecular_function,ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0005739,cellular_component,mitochondrion","K01876,ko00970,Aminoacyl-tRNA biosynthesis"]
["L3MBTL2",2.907975737,1.066645845,1.4423799,3.770664211,0.00036304,0.000970016,"ENSG00000100395","B3KPJ8,cDNA FLJ31881 fis, clone NT2RP7002829, highly similar to Lethal","-","PF02820,mbt repeat","IPR038603,FCS-type zinc finger superfamily;IPR038038,Lethal(3)malignant brain tumor-like protein 2;IPR012313,Zinc finger, FCS-type;IPR004092,Mbt repeat","ENOG410ZYE4,-;ENOG410IMEW,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0035064,molecular_function,methylated histone binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["PLAT",4.449238141,1.63386124,1.442373143,4.391977122,{"v":2.17e-05,"d":"2.17E-05"},{"v":7.69e-05,"d":"7.69E-05"},"ENSG00000104368","H2QW33,Plasminogen activator","-","PF00089,Trypsin;PF00008,-like domain;PF00051,Kringle domain;PF00039,ibronectin type I domain","IPR018114,Serine proteases, trypsin family, histidine active site;IPR000001,Kringle;IPR001254,Serine proteases, trypsin domain;IPR000083,Fibronectin, type I;IPR033116,Serine proteases, trypsin family, serine active site;IPR009003,Peptidase S1, PA clan;IPR013806,Kringle-like fold;IPR038178,Kringle superfamily;IPR034811,Tissue-type plasminogen activator;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR026280,Tissue plasminogen activator;IPR018056,Kringle, conserved site;IPR001314,Peptidase S1A, chymotrypsin family","KOG3627,Trypsin;COG5640,Secreted trypsin-like serine protease","GO:0031639,biological_process,plasminogen activation;GO:0009986,cellular_component,cell surface;GO:0016787,molecular_function,hydrolase activity;GO:0045177,cellular_component,apical part of cell;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0006508,biological_process,proteolysis;GO:0005737,cellular_component,cytoplasm;GO:0005102,molecular_function,signaling receptor binding;GO:0048008,biological_process,platelet-derived growth factor receptor signaling pathway;GO:0045861,biological_process,negative regulation of proteolysis;GO:0014909,biological_process,smooth muscle cell migration;GO:0001666,biological_process,response to hypoxia;GO:0005576,cellular_component,extracellular region;GO:0008236,molecular_function,serine-type peptidase activity;GO:0051219,molecular_function,phosphoprotein binding;GO:0030141,cellular_component,secretory granule;GO:0008233,molecular_function,peptidase activity;GO:0005615,cellular_component,extracellular space","-"]
["NOTCH1",3.70130186,1.359736968,1.44237083,4.693939046,{"v":6.52e-06,"d":"6.52E-06"},{"v":2.58E-5,"d":"2.58E-05"},"ENSG00000148400","H2QY65,Uncharacterized protein","XP_520371.3,neurogenic locus notch homolog protein 1 isoform X1","PF00066,LNR domain;PF11936,omain of unknown function (DUF3454);PF12796,Ankyrin repeats (3 copies);PF00008,-like domain;PF06816,NOTCH protein;PF07684,NOTCH protein;PF12661,Human growth factor-like EGF;PF07645,Calcium-binding EGF domain","IPR024600,Domain of unknown function DUF3454, notch;IPR010660,Notch, NOD domain;IPR018097,EGF-like calcium-binding, conserved site;IPR000800,Notch domain;IPR002110,Ankyrin repeat;IPR011656,Notch, NODP domain;IPR022362,Neurogenic locus Notch 1;IPR036770,Ankyrin repeat-containing domain superfamily;IPR001881,EGF-like calcium-binding domain;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR035993,Notch-like domain superfamily;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR008297,Notch","ENOG410IR7G,-;COG0666,FOG: Ankyrin repeat","GO:0045607,biological_process,regulation of inner ear auditory receptor cell differentiation;GO:0005912,cellular_component,adherens junction;GO:0014031,biological_process,mesenchymal cell development;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0060982,biological_process,coronary artery morphogenesis;GO:0005886,cellular_component,plasma membrane;GO:0046982,molecular_function,protein heterodimerization activity;GO:0030900,biological_process,forebrain development;GO:0005634,cellular_component,nucleus;GO:0060317,biological_process,cardiac epithelial to mesenchymal transition;GO:0003192,biological_process,mitral valve formation;GO:0010001,biological_process,glial cell differentiation;GO:0060979,biological_process,vasculogenesis involved in coronary vascular morphogenesis;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0009912,biological_process,auditory receptor cell fate commitment;GO:0001047,molecular_function,core promoter binding;GO:0003181,biological_process,atrioventricular valve morphogenesis;GO:0030335,biological_process,positive regulation of cell migration;GO:0046427,biological_process,positive regulation of JAK-STAT cascade;GO:2001027,biological_process,negative regulation of endothelial cell chemotaxis;GO:0001947,biological_process,heart looping;GO:0002193,cellular_component,MAML1-RBP-Jkappa- ICN1 complex;GO:0030324,biological_process,lung development;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0050793,biological_process,regulation of developmental process;GO:0097150,biological_process,neuronal stem cell population maintenance;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0007386,biological_process,compartment pattern specification;GO:0003273,biological_process,cell migration involved in endocardial cushion formation;GO:0003157,biological_process,endocardium development;GO:0019899,molecular_function,enzyme binding;GO:0060843,biological_process,venous endothelial cell differentiation;GO:0007050,biological_process,cell cycle arrest;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0007221,biological_process,positive regulation of transcription of Notch receptor target;GO:0007275,biological_process,multicellular organism development;GO:0007409,biological_process,axonogenesis;GO:0061419,biological_process,positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0005783,cellular_component,endoplasmic reticulum;GO:0030154,biological_process,cell differentiation;GO:0072602,biological_process,interleukin-4 secretion;GO:0030279,biological_process,negative regulation of ossification;GO:0003208,biological_process,cardiac ventricle morphogenesis;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:0001837,biological_process,epithelial to mesenchymal transition;GO:2000811,biological_process,negative regulation of anoikis;GO:0048754,biological_process,branching morphogenesis of an epithelial tube;GO:0003219,biological_process,cardiac right ventricle formation;GO:0050767,biological_process,regulation of neurogenesis;GO:0072044,biological_process,collecting duct development;GO:0060956,biological_process,endocardial cell differentiation;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0010629,biological_process,negative regulation of gene expression;GO:0010832,biological_process,negative regulation of myotube differentiation;GO:0003241,biological_process,growth involved in heart morphogenesis;GO:0003682,molecular_function,chromatin binding;GO:0060412,biological_process,ventricular septum morphogenesis;GO:0001708,biological_process,cell fate specification;GO:0045665,biological_process,negative regulation of neuron differentiation;GO:0048663,biological_process,neuron fate commitment;GO:0045165,biological_process,cell fate commitment;GO:0031490,molecular_function,chromatin DNA binding;GO:0060411,biological_process,cardiac septum morphogenesis;GO:0048711,biological_process,positive regulation of astrocyte differentiation;GO:0060948,biological_process,cardiac vascular smooth muscle cell development;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0016324,cellular_component,apical plasma membrane;GO:0010812,biological_process,negative regulation of cell-substrate adhesion;GO:0050679,biological_process,positive regulation of epithelial cell proliferation;GO:0003214,biological_process,cardiac left ventricle morphogenesis;GO:0010468,biological_process,regulation of gene expression;GO:0021915,biological_process,neural tube development;GO:0004872,-,-;GO:0055008,biological_process,cardiac muscle tissue morphogenesis;GO:0007368,biological_process,determination of left/right symmetry;GO:0035924,biological_process,cellular response to vascular endothelial growth factor stimulus;GO:0003169,biological_process,coronary vein morphogenesis;GO:0001889,biological_process,liver development;GO:0045070,biological_process,positive regulation of viral genome replication;GO:0071372,biological_process,cellular response to follicle-stimulating hormone stimulus;GO:0001701,biological_process,in utero embryonic development;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0046533,biological_process,negative regulation of photoreceptor cell differentiation;GO:0030216,biological_process,keratinocyte differentiation;GO:0060528,biological_process,secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0060038,biological_process,cardiac muscle cell proliferation;GO:0050678,biological_process,regulation of epithelial cell proliferation;GO:0003197,biological_process,endocardial cushion development;GO:1903849,biological_process,positive regulation of aorta morphogenesis;GO:0003198,biological_process,epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0007440,biological_process,foregut morphogenesis;GO:0030182,biological_process,neuron differentiation;GO:0009986,cellular_component,cell surface;GO:0032495,biological_process,response to muramyl dipeptide;GO:0003256,biological_process,regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0060548,biological_process,negative regulation of cell death;GO:0003184,biological_process,pulmonary valve morphogenesis;GO:0048845,biological_process,venous blood vessel morphogenesis;GO:0060253,biological_process,negative regulation of glial cell proliferation;GO:0045955,biological_process,negative regulation of calcium ion-dependent exocytosis;GO:0043235,cellular_component,receptor complex;GO:0048715,biological_process,negative regulation of oligodendrocyte differentiation;GO:0016021,cellular_component,integral component of membrane;GO:0042127,biological_process,regulation of cell proliferation;GO:0003209,biological_process,cardiac atrium morphogenesis;GO:0060045,biological_process,positive regulation of cardiac muscle cell proliferation;GO:0045662,biological_process,negative regulation of myoblast differentiation;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0045967,biological_process,negative regulation of growth rate;GO:0060842,biological_process,arterial endothelial cell differentiation;GO:0070986,biological_process,left/right axis specification;GO:0002040,biological_process,sprouting angiogenesis;GO:0004857,molecular_function,enzyme inhibitor activity;GO:0008593,biological_process,regulation of Notch signaling pathway;GO:0014807,biological_process,regulation of somitogenesis;GO:0060740,biological_process,prostate gland epithelium morphogenesis;GO:0006959,biological_process,humoral immune response;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0030514,biological_process,negative regulation of BMP signaling pathway;GO:0048103,biological_process,somatic stem cell division;GO:0003207,biological_process,cardiac chamber formation;GO:1902263,biological_process,apoptotic process involved in embryonic digit morphogenesis;GO:0061314,biological_process,Notch signaling involved in heart development;GO:0035116,biological_process,embryonic hindlimb morphogenesis;GO:0090051,biological_process,negative regulation of cell migration involved in sprouting angiogenesis;GO:0045596,biological_process,negative regulation of cell differentiation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0061384,biological_process,heart trabecula morphogenesis;GO:0003270,biological_process,Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation;GO:0003213,biological_process,cardiac right atrium morphogenesis;GO:0005509,molecular_function,calcium ion binding;GO:0031069,biological_process,hair follicle morphogenesis;GO:0005112,molecular_function,Notch binding;GO:0008544,biological_process,epidermis development;GO:0072144,biological_process,glomerular mesangial cell development;GO:0002437,biological_process,inflammatory response to antigenic stimulus;GO:0007507,biological_process,heart development;GO:0005737,cellular_component,cytoplasm;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0060768,biological_process,regulation of epithelial cell proliferation involved in prostate gland development;GO:2000737,biological_process,negative regulation of stem cell differentiation;GO:0003162,biological_process,atrioventricular node development;GO:0072017,biological_process,distal tubule development;GO:0050768,biological_process,negative regulation of neurogenesis;GO:0030334,biological_process,regulation of cell migration;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0035148,biological_process,tube formation;GO:0045608,biological_process,negative regulation of inner ear auditory receptor cell differentiation;GO:0003180,biological_process,aortic valve morphogenesis;GO:0003344,biological_process,pericardium morphogenesis;GO:0007492,biological_process,endoderm development;GO:0045618,biological_process,positive regulation of keratinocyte differentiation;GO:0046579,biological_process,positive regulation of Ras protein signal transduction;GO:0001190,molecular_function,transcriptional activator activity, RNA polymerase II transcription factor binding;GO:1901201,biological_process,regulation of extracellular matrix assembly;GO:0003160,biological_process,endocardium morphogenesis;GO:0045747,biological_process,positive regulation of Notch signaling pathway;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0046872,molecular_function,metal ion binding;GO:0003203,biological_process,endocardial cushion morphogenesis;GO:0071944,cellular_component,cell periphery;GO:0007219,biological_process,Notch signaling pathway;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0043086,biological_process,negative regulation of catalytic activity;GO:2000974,biological_process,negative regulation of pro-B cell differentiation;GO:0030513,biological_process,positive regulation of BMP signaling pathway;GO:0003222,biological_process,ventricular trabecula myocardium morphogenesis;GO:0045668,biological_process,negative regulation of osteoblast differentiation","-"]
["PRKAA1",13.71284398,5.042512259,1.442365151,5.965162899,{"v":2.69e-08,"d":"2.69E-08"},{"v":1.8E-7,"d":"1.80E-07"},"ENSG00000132356","H2R5J1,Non-specific serine/threonine protein kinase","XP_009447514.1,-","PF00069,Protein kinase domain;PF16579,Adenylate sensor of SNF1-like protein kinase","IPR028375,KA1 domain/Ssp2, C-terminal;IPR032270,AMPK, C-terminal adenylate sensor domain;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain","KOG0586,Serine/threonine protein kinase;ENOG410XNQ0,-","GO:1903109,biological_process,positive regulation of mitochondrial transcription;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0009411,biological_process,response to UV;GO:0035404,biological_process,histone-serine phosphorylation;GO:0035174,molecular_function,histone serine kinase activity;GO:0033135,biological_process,regulation of peptidyl-serine phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0016607,cellular_component,nuclear speck;GO:0008610,biological_process,lipid biosynthetic process;GO:0005634,cellular_component,nucleus;GO:0042542,biological_process,response to hydrogen peroxide;GO:0016301,molecular_function,kinase activity;GO:0042593,biological_process,glucose homeostasis;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0004679,molecular_function,AMP-activated protein kinase activity;GO:0016310,biological_process,phosphorylation;GO:0005524,molecular_function,ATP binding;GO:1903955,biological_process,positive regulation of protein targeting to mitochondrion;GO:0005829,cellular_component,cytosol;GO:0010508,biological_process,positive regulation of autophagy;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0042149,biological_process,cellular response to glucose starvation;GO:0006006,biological_process,glucose metabolic process;GO:0010628,biological_process,positive regulation of gene expression;GO:0019395,biological_process,fatty acid oxidation;GO:0050995,biological_process,negative regulation of lipid catabolic process;GO:0016740,molecular_function,transferase activity;GO:0048643,biological_process,positive regulation of skeletal muscle tissue development;GO:0031669,biological_process,cellular response to nutrient levels;GO:1901563,biological_process,response to camptothecin;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0071380,biological_process,cellular response to prostaglandin E stimulus;GO:0032007,biological_process,negative regulation of TOR signaling;GO:0061762,biological_process,CAMKK-AMPK signaling cascade;GO:0003682,molecular_function,chromatin binding;GO:0005622,cellular_component,intracellular;GO:0042752,biological_process,regulation of circadian rhythm;GO:0010332,biological_process,response to gamma radiation","K07198,ko04068,FoxO signaling pathway;K07198,ko04151,PI3K-Akt signaling pathway;K07198,ko04931,Insulin resistance;K07198,ko04211,Longevity regulating pathway;K07198,ko04150,mTOR signaling pathway;K07198,ko04922,Glucagon signaling pathway;K07198,ko04910,Insulin signaling pathway;K07198,ko04140,Regulation of autophagy;K07198,ko05410,Hypertrophic cardiomyopathy (HCM);K07198,ko04152,AMPK signaling pathway;K07198,ko04921,Oxytocin signaling pathway;K07198,ko04213,Longevity regulating pathway - multiple species;K07198,ko04710,Circadian rhythm;K07198,ko04920,Adipocytokine signaling pathway;K07198,ko04932,Non-alcoholic fatty liver disease (NAFLD)"]
["MAGEF1",105.0862746,38.65467292,1.442363297,6.889052806,{"v":1.18e-09,"d":"1.18E-09"},{"v":1.07E-8,"d":"1.07E-08"},"ENSG00000177383","G1SBB2,MAGE family member F1","XP_003256626.1,melanoma-associated antigen F1","PF01454,MAGE family","IPR037445,Melanoma-associated antigen;IPR002190,MAGE homology domain","ENOG4111S70,-;KOG4562,Uncharacterized conserved protein (tumor-rejection antigen MAGE in humans)","GO:2000042,biological_process,negative regulation of double-strand break repair via homologous recombination;GO:0097428,biological_process,protein maturation by iron-sulfur cluster transfer;GO:2000060,biological_process,positive regulation of ubiquitin-dependent protein catabolic process;GO:0016567,biological_process,protein ubiquitination","-"]
["HSF1",14.58677357,5.371531887,1.440155731,5.751692378,{"v":7.46e-08,"d":"7.46E-08"},{"v":4.5e-07,"d":"4.50E-07"},"ENSG00000185122","Q53HT3,Heat shock transcription factor 1 variant","-","PF00447,HSF-type DNA-binding;PF06546,Vertebrate heat shock transcription factor","IPR000232,Heat shock factor (HSF)-type, DNA-binding;IPR027725,Heat shock transcription factor family;IPR036390,Winged helix DNA-binding domain superfamily;IPR010542,Vertebrate heat shock transcription factor, C-terminal domain;IPR036388,Winged helix-like DNA-binding domain superfamily","COG5169,Heat shock transcription factor;KOG0627,Heat shock transcription factor","GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["UBAC2",6.964397048,2.562651319,1.439705829,4.510861084,{"v":1.72e-05,"d":"1.72E-05"},{"v":6.22e-05,"d":"6.22E-05"},"ENSG00000134882","G2HEI7,Phosphoglycerate dehydrogenase-like protein 1","NP_001233420.1,-","PF00627,UBA/TS-N domain","IPR015940,Ubiquitin-associated domain;IPR009060,UBA-like superfamily","KOG4463,Uncharacterized conserved protein;ENOG4111CBK,-","GO:1904153,biological_process,negative regulation of retrograde protein transport, ER to cytosol;GO:0005783,cellular_component,endoplasmic reticulum;GO:0070972,biological_process,protein localization to endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0043130,molecular_function,ubiquitin binding;GO:0016021,cellular_component,integral component of membrane","-"]
["TTF2",2.449004543,0.901146888,1.438949076,4.162399936,{"v":5.55e-05,"d":"5.55E-05"},0.000178167,"ENSG00000116830","A0A024R0F1,Transcription termination factor, RNA polymerase II, isoform CRA_a","XP_016858044.1,-;NP_003585.3,transcription termination factor 2","PF00271,Helicase conserved C-terminal domain;PF00176,SNF2 family N-terminal domain;PF06839,RF zinc finger","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR010666,Zinc finger, GRF-type;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR001650,Helicase, C-terminal","ENOG410INU3,-;ENOG410XPDU,-","GO:0005829,cellular_component,cytosol;GO:0005524,molecular_function,ATP binding;GO:0008270,molecular_function,zinc ion binding","K15173,ko04918,Thyroid hormone synthesis"]
["ATP5F1",38.32493034,14.14095861,1.437748548,6.486774378,{"v":4.41e-09,"d":"4.41E-09"},{"v":3.51e-08,"d":"3.51E-08"},"ENSG00000116459","Q08ET0,Cell proliferation-inducing protein 47","NP_001679.2,ATP synthase F(0) complex subunit B1, mitochondrial precursor","PF05405,Mitochondrial ATP synthase B chain precursor (ATP-synt_B)","IPR008688,ATP synthase, F0 complex, subunit B/MI25;IPR013837,ATP synthase, F0 complex, subunit B","ENOG4111WYE,-;ENOG410INNH,-","GO:0015986,biological_process,ATP synthesis coupled proton transport;GO:0043209,cellular_component,myelin sheath;GO:0015078,molecular_function,proton transmembrane transporter activity;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0000276,cellular_component,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005654,cellular_component,nucleoplasm","K02127,ko00190,Oxidative phosphorylation;K02127,ko05016,Huntington's disease;K02127,ko05012,Parkinson's disease;K02127,ko05010,Alzheimer's disease"]
["JMJD6",2.983667431,1.097883884,1.437589086,3.700909408,0.000486893,0.001263395,"ENSG00000070495","H2QDY5,Jumonji domain containing 6","-","PF02373,JmjC domain, hydroxylase","IPR003347,JmjC domain","KOG2130,Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain;ENOG410XQCR,-","GO:0005886,cellular_component,plasma membrane;GO:0005506,molecular_function,iron ion binding;GO:0005634,cellular_component,nucleus;GO:0070815,molecular_function,peptidyl-lysine 5-dioxygenase activity;GO:0007507,biological_process,heart development;GO:0003727,molecular_function,single-stranded RNA binding;GO:0060041,biological_process,retina development in camera-type eye;GO:0048821,biological_process,erythrocyte development;GO:0033749,molecular_function,histone demethylase activity (H4-R3 specific);GO:0070078,biological_process,histone H3-R2 demethylation;GO:0005829,cellular_component,cytosol;GO:0001822,biological_process,kidney development;GO:0018395,biological_process,peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine;GO:0048024,biological_process,regulation of mRNA splicing, via spliceosome;GO:0030324,biological_process,lung development;GO:0033746,molecular_function,histone demethylase activity (H3-R2 specific);GO:0042116,biological_process,macrophage activation;GO:0043277,biological_process,apoptotic cell clearance;GO:0002040,biological_process,sprouting angiogenesis;GO:0004872,-,-;GO:0005654,cellular_component,nucleoplasm;GO:0033077,biological_process,T cell differentiation in thymus;GO:0005730,cellular_component,nucleolus;GO:0042802,molecular_function,identical protein binding;GO:0070079,biological_process,histone H4-R3 demethylation;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0003723,molecular_function,RNA binding;GO:0043654,biological_process,recognition of apoptotic cell;GO:0001568,biological_process,blood vessel development;GO:0055114,biological_process,oxidation-reduction process;GO:0042803,molecular_function,protein homodimerization activity;GO:0030529,,","-"]
["IPO9-AS1",27.21285809,10.03051362,1.437443908,4.620649604,{"v":7.85e-06,"d":"7.85E-06"},{"v":3.05e-05,"d":"3.05E-05"},"ENSG00000231871","G1ST56,Importin 9","-","PF03810,Importin-beta N-terminal domain","IPR016024,Armadillo-type fold;IPR001494,Importin-beta, N-terminal domain","COG5657,CAS/CSE protein involved in chromosome segregation;KOG2274,Predicted importin 9","GO:0005737,cellular_component,cytoplasm;GO:0008536,molecular_function,Ran GTPase binding;GO:0005634,cellular_component,nucleus;GO:0008565,molecular_function,protein transporter activity;GO:0006886,biological_process,intracellular protein transport","-"]
["OIP5-AS1",4.834271087,1.784011498,1.436789048,5.421119358,{"v":2.64e-07,"d":"2.64E-07"},{"v":1.4e-06,"d":"1.40E-06"},"ENSG00000247556","A0A024R9P8,HCG1998670, isoform CRA_a","-","-","-","-","-","-"]
["MSANTD3-TMEFF1",6.886229443,2.53388841,1.436401373,3.398701088,0.001397979,0.003261478,"ENSG00000251349","A0A0A6YYJ0,Protein MSANTD3-TMEFF1","-","PF07648,Kazal-type serine protease inhibitor domain","IPR013032,EGF-like, conserved site;IPR002350,Kazal domain;IPR036058,Kazal domain superfamily;IPR000742,EGF-like domain","ENOG410XQG4,-;ENOG410IP0E,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["LITAF",70.06482152,25.90224862,1.435374155,7.929265815,1.12E-10,{"v":1.26E-9,"d":"1.26E-09"},"ENSG00000189067","G3RN15,Lipopolysaccharide induced TNF factor","-","PF10601,LITAF-like zinc ribbon domain","IPR037519,LITAF domain containing protein","-","-","-"]
["BRD3",18.82137568,6.957368089,1.435104529,6.484852864,{"v":4.41e-09,"d":"4.41E-09"},{"v":3.51e-08,"d":"3.51E-08"},"ENSG00000169925","A0A024R8H6,Bromodomain containing 3, isoform CRA_a","XP_006717354.1,-;XP_011517354.1,-;NP_031397.1,bromodomain-containing protein 3","PF17035,Bromodomain extra-terminal - transcription regulation;PF00439,Bromodomain","IPR018359,Bromodomain, conserved site;IPR027353,NET domain;IPR001487,Bromodomain;IPR038336,NET domain superfamily;IPR036427,Bromodomain-like superfamily","KOG1474,Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins;COG5076,Transcription factor involved in chromatin remodeling, contains bromodomain","-","-"]
["TOR1AIP1",6.915116035,2.555877107,1.43466238,5.537461858,{"v":1.58e-07,"d":"1.58E-07"},{"v":8.87e-07,"d":"8.87E-07"},"ENSG00000143337","J3KN66,Torsin-1A-interacting protein 1","XP_011507705.1,torsin-1A-interacting protein 1 isoform X1","PF05609,Lamina-associated polypeptide 1C (LAP1C)","IPR038599,LAP1C-like, C-terminal domain superfamily;IPR008662,Lamina-associated polypeptide 1C","ENOG410IJUB,-;ENOG4111IZJ,-","GO:0031965,cellular_component,nuclear membrane","-"]
["HELB",0.774551068,0.285007346,1.43442656,3.014598492,0.004704587,0.009714001,"ENSG00000127311","H2Q6F0,Uncharacterized protein","XP_009423254.1,DNA helicase B isoform X1","PF13604,AAA domain;PF13538,UvrD-like helicase C-terminal domain","IPR027785,UvrD-like helicase C-terminal domain;IPR027044,DNA helicase B;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410IK73,-;COG0507,ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member","GO:2000042,biological_process,negative regulation of double-strand break repair via homologous recombination;GO:0043141,molecular_function,ATP-dependent 5'-3' DNA helicase activity;GO:0004004,molecular_function,ATP-dependent RNA helicase activity;GO:0035861,cellular_component,site of double-strand break;GO:0005658,cellular_component,alpha DNA polymerase:primase complex;GO:0006260,biological_process,DNA replication;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0017116,molecular_function,single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0003723,molecular_function,RNA binding;GO:0005737,cellular_component,cytoplasm;GO:0005662,cellular_component,DNA replication factor A complex;GO:0006396,biological_process,RNA processing;GO:0032508,biological_process,DNA duplex unwinding;GO:0006269,biological_process,DNA replication, synthesis of RNA primer;GO:0006261,biological_process,DNA-dependent DNA replication;GO:0005634,cellular_component,nucleus;GO:1903775,biological_process,regulation of DNA double-strand break processing;GO:0004003,molecular_function,ATP-dependent DNA helicase activity","-"]
["RP11-156P1.3",9.007598104,3.327526025,1.433887656,4.427298745,{"v":1.76e-05,"d":"1.76E-05"},{"v":6.34e-05,"d":"6.34E-05"},"ENSG00000262879","G3R2S1,Uncharacterized protein","-","PF14914,LRRC37A/B like protein 1 C-terminal domain;PF15779,Leucine-rich repeat-containing protein 37 family","IPR015753,Leucine-rich repeat-containing protein 37;IPR029423,LRRC37A/B like protein 1, C-terminal","-","-","-"]
["EFR3A",13.14326768,4.864456503,1.432936664,5.825749778,{"v":5.35e-08,"d":"5.35E-08"},{"v":3.35e-07,"d":"3.35E-07"},"ENSG00000132294","A0A1B0GUZ7,Protein EFR3 homolog A","-","-","IPR016024,Armadillo-type fold","-","GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane","-"]
["DTX3L",11.61401869,4.299605534,1.432352646,5.573033244,{"v":1.91E-7,"d":"1.91E-07"},{"v":1.06E-6,"d":"1.06E-06"},"ENSG00000163840","K7CYW6,Deltex 3-like","-","PF13923,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG4111QEI,-;ENOG410IEH5,-","-","-"]
["DPY19L1",2.685516138,0.991654262,1.432278189,3.627564925,0.000535418,1.378858E-3,"ENSG00000173852","A0A1B0GW05,Probable C-mannosyltransferase DPY19L1","XP_011513547.1,probable C-mannosyltransferase DPY19L1 isoform X1","PF10034,Q-cell neuroblast polarisation","IPR018732,Dpy-19/Dpy-19-like;IPR030041,Probable C-mannosyltransferase DPY19L1","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TAPBP",13.29138076,4.925320773,1.430947421,5.553516312,{"v":2.13e-07,"d":"2.13E-07"},{"v":1.16e-06,"d":"1.16E-06"},"ENSG00000231925","A0A0A0MSV9,Tapasin","NP_757345.2,tapasin isoform 2 precursor","PF07654,Immunoglobulin C1-set domain","IPR007110,Immunoglobulin-like domain;IPR003597,Immunoglobulin C1-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR008056,Tapasin","ENOG4111QPK,-;ENOG410II43,-","GO:0042824,cellular_component,MHC class I peptide loading complex;GO:0002397,biological_process,MHC class I protein complex assembly;GO:0019885,biological_process,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SETD8P1",24.75220158,9.163469227,1.430705033,4.383615969,{"v":2.67e-05,"d":"2.67E-05"},{"v":9.23e-05,"d":"9.23E-05"},"ENSG00000279730","A0A096N875,Histone-lysine N-methyltransferase","XP_003907384.1,N-lysine methyltransferase KMT5A isoform X2","PF00856,SET domain","IPR001214,SET domain;IPR016858,Class V SAM-dependent methyltransferases","-","GO:0016279,molecular_function,protein-lysine N-methyltransferase activity;GO:0018026,biological_process,peptidyl-lysine monomethylation;GO:0034968,biological_process,histone lysine methylation;GO:0043516,biological_process,regulation of DNA damage response, signal transduction by p53 class mediator;GO:0016740,molecular_function,transferase activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0002039,molecular_function,p53 binding;GO:0003714,molecular_function,transcription corepressor activity;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0045892,biological_process,negative regulation of transcription, DNA-templated","-"]
["NRP1",0.618278455,0.227504562,1.430494488,2.486380441,0.019530136,0.034357071,"ENSG00000099250","G3QGL8,Neuropilin","XP_004049296.1,neuropilin-1 isoform X1","PF00754,5/8 type C domain;PF00431,CUB domain;PF11980,C-terminal domain of neuropilin glycoprotein;PF00629,MAM domain, meprin/A5/mu","IPR000421,Coagulation factor 5/8 C-terminal domain;IPR035914,Spermadhesin, CUB domain superfamily;IPR027146,Neuropilin-1;IPR022579,Neuropilin, C-terminal;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000859,CUB domain;IPR000998,MAM domain;IPR008979,Galactose-binding-like domain superfamily;IPR014648,Neuropilin","-","GO:0060982,biological_process,coronary artery morphogenesis;GO:0005886,cellular_component,plasma membrane;GO:0005769,cellular_component,early endosome;GO:0042327,biological_process,positive regulation of phosphorylation;GO:0060385,biological_process,axonogenesis involved in innervation;GO:0021828,biological_process,gonadotrophin-releasing hormone neuronal migration to the hypothalamus;GO:0060978,biological_process,angiogenesis involved in coronary vascular morphogenesis;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0050918,biological_process,positive chemotaxis;GO:0048846,biological_process,axon extension involved in axon guidance;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0038084,biological_process,vascular endothelial growth factor signaling pathway;GO:1903375,biological_process,facioacoustic ganglion development;GO:0038085,molecular_function,vascular endothelial growth factor binding;GO:1901166,biological_process,neural crest cell migration involved in autonomic nervous system development;GO:0002042,biological_process,cell migration involved in sprouting angiogenesis;GO:0021636,biological_process,trigeminal nerve morphogenesis;GO:0061549,biological_process,sympathetic ganglion development;GO:0031290,biological_process,retinal ganglion cell axon guidance;GO:0007275,biological_process,multicellular organism development;GO:0090050,biological_process,positive regulation of cell migration involved in sprouting angiogenesis;GO:0030154,biological_process,cell differentiation;GO:0048485,biological_process,sympathetic nervous system development;GO:0009887,biological_process,animal organ morphogenesis;GO:0060666,biological_process,dichotomous subdivision of terminal units involved in salivary gland branching;GO:0097443,cellular_component,sorting endosome;GO:0048843,biological_process,negative regulation of axon extension involved in axon guidance;GO:0097490,biological_process,sympathetic neuron projection extension;GO:0061551,biological_process,trigeminal ganglion development;GO:0003148,biological_process,outflow tract septum morphogenesis;GO:0007507,biological_process,heart development;GO:0007411,biological_process,axon guidance;GO:0001569,biological_process,branching involved in blood vessel morphogenesis;GO:0030424,cellular_component,axon;GO:0007399,biological_process,nervous system development;GO:0090259,biological_process,regulation of retinal ganglion cell axon guidance;GO:0061441,biological_process,renal artery morphogenesis;GO:1902336,biological_process,positive regulation of retinal ganglion cell axon guidance;GO:0008045,biological_process,motor neuron axon guidance;GO:1902285,biological_process,semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:0035924,biological_process,cellular response to vascular endothelial growth factor stimulus;GO:0005925,cellular_component,focal adhesion;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:2001237,biological_process,negative regulation of extrinsic apoptotic signaling pathway;GO:0097475,biological_process,motor neuron migration;GO:0051491,biological_process,positive regulation of filopodium assembly;GO:0038189,biological_process,neuropilin signaling pathway;GO:0019901,molecular_function,protein kinase binding;GO:0032489,biological_process,regulation of Cdc42 protein signal transduction;GO:0007413,biological_process,axonal fasciculation;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0071679,biological_process,commissural neuron axon guidance;GO:0048012,biological_process,hepatocyte growth factor receptor signaling pathway;GO:0048844,biological_process,artery morphogenesis;GO:0021612,biological_process,facial nerve structural organization;GO:0021649,biological_process,vestibulocochlear nerve structural organization;GO:2000251,biological_process,positive regulation of actin cytoskeleton reorganization;GO:0150018,biological_process,basal dendrite development;GO:1900026,biological_process,positive regulation of substrate adhesion-dependent cell spreading;GO:0001764,biological_process,neuron migration;GO:0016021,cellular_component,integral component of membrane;GO:0021785,biological_process,branchiomotor neuron axon guidance;GO:1905040,biological_process,otic placode development;GO:0150020,biological_process,basal dendrite arborization;GO:0017154,molecular_function,semaphorin receptor activity;GO:0002040,biological_process,sprouting angiogenesis;GO:0034446,biological_process,substrate adhesion-dependent cell spreading;GO:0021637,biological_process,trigeminal nerve structural organization;GO:0051496,biological_process,positive regulation of stress fiber assembly;GO:0036486,biological_process,ventral trunk neural crest cell migration;GO:0048010,biological_process,vascular endothelial growth factor receptor signaling pathway;GO:0097491,biological_process,sympathetic neuron projection guidance;GO:0035767,biological_process,endothelial cell chemotaxis;GO:0038190,biological_process,VEGF-activated neuropilin signaling pathway;GO:0006930,biological_process,substrate-dependent cell migration, cell extension;GO:0061299,biological_process,retina vasculature morphogenesis in camera-type eye;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0035729,biological_process,cellular response to hepatocyte growth factor stimulus;GO:0010595,biological_process,positive regulation of endothelial cell migration;GO:0005096,molecular_function,GTPase activator activity;GO:0048841,biological_process,regulation of axon extension involved in axon guidance;GO:0043005,cellular_component,neuron projection;GO:0043542,biological_process,endothelial cell migration;GO:0016358,biological_process,dendrite development;GO:1902287,biological_process,semaphorin-plexin signaling pathway involved in axon guidance;GO:0048008,biological_process,platelet-derived growth factor receptor signaling pathway;GO:0030517,biological_process,negative regulation of axon extension;GO:0097374,biological_process,sensory neuron axon guidance;GO:0005829,cellular_component,cytosol;GO:0005021,molecular_function,vascular endothelial growth factor-activated receptor activity;GO:0021675,biological_process,nerve development;GO:0048842,biological_process,positive regulation of axon extension involved in axon guidance;GO:0019838,molecular_function,growth factor binding;GO:0001525,biological_process,angiogenesis;GO:0016020,cellular_component,membrane;GO:0005883,cellular_component,neurofilament;GO:1902946,biological_process,protein localization to early endosome;GO:0048666,biological_process,neuron development;GO:1904835,biological_process,dorsal root ganglion morphogenesis;GO:0071526,biological_process,semaphorin-plexin signaling pathway;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0051894,biological_process,positive regulation of focal adhesion assembly;GO:0046872,molecular_function,metal ion binding;GO:1902378,biological_process,VEGF-activated neuropilin signaling pathway involved in axon guidance;GO:1901998,biological_process,toxin transport;GO:0016477,biological_process,cell migration","K06724,ko05166,HTLV-I infection;K06724,ko04360,Axon guidance"]
["RP11-626G11.3",6.26543919,2.305459596,1.430494488,2.486380441,0.019530136,0.034357071,"ENSG00000261759","I7GEV6,Macaca fascicularis brain cDNA clone: QtrA-17464, similar to human FLJ41327 protein","-","-","-","-","-","-"]
["ADAT3",3.184534805,1.171795959,1.430494488,2.486380441,0.019530136,0.034357071,"ENSG00000213638","D6W601,HCG22695, isoform CRA_a","NP_612431.2,probable inactive tRNA-specific adenosine deaminase-like protein 3 isoform 1","PF00383,Cytidine and deoxycytidylate deaminase zinc-binding region","IPR016193,Cytidine deaminase-like;IPR002125,Cytidine and deoxycytidylate deaminase domain","COG0590,Cytosine/adenosine deaminases;KOG2771,Subunit of tRNA-specific adenosine-34 deaminase","GO:0003824,molecular_function,catalytic activity","-"]
["RP3-508I15.18",15.45293787,5.686133537,1.430494488,2.486380441,0.019530136,0.034357071,"ENSG00000244491","A0A1U7SLM8,SUN domain-containing protein 2-like","XP_008046440.1,-","-","IPR012919,SUN domain;IPR008979,Galactose-binding-like domain superfamily;IPR030272,SUN domain-containing protein 2","-","GO:0005639,cellular_component,integral component of nuclear inner membrane;GO:0034993,cellular_component,meiotic nuclear membrane microtubule tethering complex","-"]
["GLA",3.449784193,1.269398334,1.430494488,2.486380441,0.019530136,0.034357071,"ENSG00000102393","Q53Y83,Galactosidase, alpha","NP_000160.1,alpha-galactosidase A precursor","PF17450,Alpha galactosidase A C-terminal beta sandwich domain;PF16499,Alpha galactosidase A","IPR035373,Alpha galactosidase A, C-terminal beta-sandwich domain;IPR017853,Glycoside hydrolase superfamily;IPR002241,Glycoside hydrolase, family 27;IPR013785,Aldolase-type TIM barrel;IPR013780,Glycosyl hydrolase, all-beta;IPR000111,Glycoside hydrolase family 27/36, conserved site","ENOG410XPF1,-;KOG2366,Alpha-D-galactosidase (melibiase)","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0005975,biological_process,carbohydrate metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0004557,molecular_function,alpha-galactosidase activity;GO:0003824,molecular_function,catalytic activity;GO:0005764,cellular_component,lysosome;GO:0004553,molecular_function,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0008152,biological_process,metabolic process;GO:0016936,molecular_function,galactoside binding","K01189,ko00600,Sphingolipid metabolism;K01189,ko00052,Galactose metabolism;K01189,ko04142,Lysosome;K01189,ko00561,Glycerolipid metabolism;K01189,ko00603,Glycosphingolipid biosynthesis - globo series"]
["CARD10",7.352357648,2.724731408,1.430066497,4.876046802,{"v":3.28e-06,"d":"3.28E-06"},{"v":1.39e-05,"d":"1.39E-05"},"ENSG00000100065","Q17RA1,Caspase recruitment domain family, member 10","-","PF00619,Caspase recruitment domain","IPR001315,CARD domain;IPR011029,Death-like domain superfamily","COG0194,Guanylate kinase;KOG0708,Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains)","GO:0042981,biological_process,regulation of apoptotic process;GO:0005515,molecular_function,protein binding","-"]
["P2RX4",2.386534123,0.883514621,1.429266728,3.824758975,2.7273E-4,0.000749878,"ENSG00000135124","A0A1D5R6U8,p2X purinoceptor","-","-","IPR003047,P2X4 purinoceptor;IPR027309,P2X purinoreceptor extracellular domain superfamily;IPR001429,P2X purinoreceptor","-","GO:0005216,molecular_function,ion channel activity;GO:0004931,molecular_function,extracellularly ATP-gated cation channel activity;GO:0098655,biological_process,cation transmembrane transport;GO:0033198,biological_process,response to ATP;GO:0005524,molecular_function,ATP binding;GO:0006811,biological_process,ion transport;GO:0035590,biological_process,purinergic nucleotide receptor signaling pathway;GO:0098794,cellular_component,postsynapse;GO:0016020,cellular_component,membrane;GO:0001614,molecular_function,purinergic nucleotide receptor activity;GO:0060079,biological_process,excitatory postsynaptic potential;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["COPG2",4.704453229,1.741627396,1.429266728,3.824758975,2.7273E-4,0.000749878,"ENSG00000158623","K7DFG0,Coatomer subunit gamma","XP_519383.3,-","PF16381,Coatomer subunit gamma-1 C-terminal appendage platform;PF08752,Coatomer gamma subunit appendage platform subdomain;PF01602,Adaptin N terminal region","IPR013041,Clathrin adaptor, appendage, Ig-like subdomain superfamily;IPR032154,Coatomer subunit gamma, C-terminal;IPR013040,Coatomer, gamma subunit, appendage, Ig-like subdomain;IPR002553,Clathrin/coatomer adaptor, adaptin-like, N-terminal;IPR017106,Coatomer gamma subunit;IPR012295,TBP domain superfamily;IPR016024,Armadillo-type fold;IPR009028,Coatomer/calthrin adaptor appendage, C-terminal subdomain;IPR011989,Armadillo-like helical;IPR037067,Coatomer, gamma subunit, appendage domain superfamily","COG5240,Vesicle coat complex COPI, gamma subunit;KOG1078,Vesicle coat complex COPI, gamma subunit","GO:0005794,cellular_component,Golgi apparatus;GO:0030126,cellular_component,COPI vesicle coat;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0006891,biological_process,intra-Golgi vesicle-mediated transport;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0005198,molecular_function,structural molecule activity;GO:0030663,cellular_component,COPI-coated vesicle membrane;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0030117,cellular_component,membrane coat;GO:0006886,biological_process,intracellular protein transport","-"]
["ESYT2",21.51125295,7.986161736,1.428966798,6.72282166,{"v":2.53e-09,"d":"2.53E-09"},{"v":2.12e-08,"d":"2.12E-08"},"ENSG00000117868","A0A087WXU3,Extended synaptotagmin-2","-","PF17047,Synaptotagmin-like mitochondrial-lipid-binding domain;PF00168,C2 domain","IPR031468,Synaptotagmin-like mitochondrial-lipid-binding domain;IPR037733,Extended synaptotagmin, C2A domain;IPR037749,Extended synaptotagmin, C2B domain;IPR037752,Extended synaptotagmin, C-terminal C2 domain;IPR000008,C2 domain;IPR035892,C2 domain superfamily","ENOG410XPR4,-;ENOG410ISCC,-","GO:0006869,biological_process,lipid transport;GO:0061817,biological_process,endoplasmic reticulum-plasma membrane tethering;GO:0008289,molecular_function,lipid binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PHC2",11.6783678,4.33605586,1.427962808,5.37320184,{"v":4.39E-7,"d":"4.39E-07"},{"v":2.24e-06,"d":"2.24E-06"},"ENSG00000134686","H2PYL7,Uncharacterized protein","XP_009451544.1,polyhomeotic-like protein 2 isoform X2;XP_009451553.1,-","PF00536,SAM domain (Sterile alpha motif);PF16616,Unstructured region on Polyhomeotic-like protein 1 and 2","IPR038603,FCS-type zinc finger superfamily;IPR012313,Zinc finger, FCS-type;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","ENOG4111F0Y,-;ENOG410IDZN,-","GO:0007283,biological_process,spermatogenesis;GO:0000792,cellular_component,heterochromatin;GO:0031519,cellular_component,PcG protein complex;GO:0035102,cellular_component,PRC1 complex;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["DGCR2",5.041526724,1.870692282,1.427316438,4.338558855,{"v":3.33e-05,"d":"3.33E-05"},0.000112375,"ENSG00000070413","F6SYP7,Integral membrane protein DGCR2/IDD","-","PF00057,Low-density lipoprotein receptor domain class A;PF00059,Lectin C-type domain","IPR016187,C-type lectin fold;IPR001304,C-type lectin-like;IPR016186,C-type lectin-like/link domain superfamily;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR001007,VWFC domain;IPR036055,LDL receptor-like superfamily;IPR034010,DGCR2-like, C-type lectin-like domain","ENOG4110Q97,-;ENOG410IPT1,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SLC37A2",3.466299405,1.285761439,1.426970774,3.998022081,0.000185746,5.31482E-4,"ENSG00000134955","G3RHQ0,Solute carrier family 37 member 2","XP_004052406.1,glucose-6-phosphate exchanger SLC37A2 isoform X1","-","IPR036259,MFS transporter superfamily;IPR000849,Sugar phosphate transporter;IPR020846,Major facilitator superfamily domain;IPR011701,Major facilitator superfamily","-","GO:0022857,molecular_function,transmembrane transporter activity;GO:0055085,biological_process,transmembrane transport;GO:0015760,biological_process,glucose-6-phosphate transport;GO:0061513,molecular_function,glucose 6-phosphate:inorganic phosphate antiporter activity;GO:0035435,biological_process,phosphate ion transmembrane transport;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["PPT1",50.63805276,18.83123248,1.426593677,6.855166282,{"v":1.77e-09,"d":"1.77E-09"},{"v":1.54e-08,"d":"1.54E-08"},"ENSG00000131238","H2PYR6,Palmitoyl-protein thioesterase 1","XP_001172215.1,palmitoyl-protein thioesterase 1","PF02089,Palmitoyl protein thioesterase","IPR002472,Palmitoyl protein thioesterase;IPR030294,Palmitoyl-protein thioesterase 1;IPR029058,Alpha/Beta hydrolase fold","COG1075,Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold;KOG2541,Palmitoyl protein thioesterase","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0007268,biological_process,chemical synaptic transmission;GO:0002084,biological_process,protein depalmitoylation;GO:0005764,cellular_component,lysosome;GO:0007399,biological_process,nervous system development;GO:0008474,molecular_function,palmitoyl-(protein) hydrolase activity;GO:0098599,molecular_function,palmitoyl hydrolase activity","K01074,ko01212,Fatty acid metabolism;K01074,ko04142,Lysosome;K01074,ko00062,Fatty acid elongation"]
["CCDC85A",7.752340253,2.880015213,1.425839619,4.461775369,{"v":2.57e-05,"d":"2.57E-05"},{"v":8.93e-05,"d":"8.93E-05"},"ENSG00000055813","H2P656,Coiled-coil domain containing 85A","-","PF10226,CCDC85 family","IPR019359,CCDC85 family","KOG3819,Uncharacterized conserved proteins (Hepatitis delta antigen-interacting protein A);ENOG410YXPD,-","-","-"]
["RND3",41.16240137,15.31648825,1.42567541,6.678505767,{"v":3.08e-09,"d":"3.08E-09"},{"v":2.53e-08,"d":"2.53E-08"},"ENSG00000115963","A0A061I240,Rho-related GTP-binding protein RhoE-like protein","XP_003512197.1,-;XP_007614663.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR003578,Small GTPase superfamily, Rho type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005525,molecular_function,GTP binding;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular","-"]
["RARG",11.8567968,4.409747944,1.425568121,5.413011902,{"v":3.46E-7,"d":"3.46E-07"},{"v":1.79E-6,"d":"1.79E-06"},"ENSG00000172819","G7N741,Retinoic acid receptor gamma","-","-","IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR003078,Retinoic acid receptor;IPR013088,Zinc finger, NHR/GATA-type","KOG3575,FOG: Hormone receptors;ENOG410XRZC,-","GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0003708,molecular_function,retinoic acid receptor activity;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0048384,biological_process,retinoic acid receptor signaling pathway;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway","-"]
["RP11-110G21.1",4.737647667,1.753916251,1.424970495,2.893783337,0.006918611,0.013698475,"ENSG00000228801","B4DRW2,cDNA FLJ58935","-","-","-","-","-","-"]
["GTF2I",5.482649455,2.040441074,1.424529963,5.327951956,{"v":4.8e-07,"d":"4.80E-07"},{"v":2.43E-6,"d":"2.43E-06"},"ENSG00000263001","H2QUR5,Uncharacterized protein","XP_016800725.1,-;XP_016813068.1,-;XP_001151627.2,-;XP_016813069.1,-;XP_016800732.1,-","PF02946,TF2I-like repeat","IPR016659,Transcription factor II-I;IPR004212,GTF2I-like repeat;IPR036647,GTF2I-like repeat superfamily","ENOG410IEPZ,-;ENOG41100H8,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0005634,cellular_component,nucleus;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0006351,biological_process,transcription, DNA-templated;GO:0007275,biological_process,multicellular organism development;GO:0005654,cellular_component,nucleoplasm","K03121,ko04022,cGMP-PKG signaling pathway;K03121,ko05168,Herpes simplex infection;K03121,ko03022,Basal transcription factors"]
["USP19",3.231877741,1.200651256,1.424035245,3.757652651,4.64327E-4,1.208345E-3,"ENSG00000172046","G3RG07,Ubiquitin specific peptidase 19","-","PF04969,CS domain;PF16602,Linker region of USP19 deubiquitinase;PF00443,Ubiquitin carboxyl-terminal hydrolase;PF01753,MYND finger","IPR018200,Ubiquitin specific protease, conserved site;IPR002893,Zinc finger, MYND-type;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase;IPR028889,Ubiquitin specific protease domain;IPR007052,CS domain;IPR008978,HSP20-like chaperone","-","GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function,metal ion binding;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016020,cellular_component,membrane;GO:0016579,biological_process,protein deubiquitination;GO:0016021,cellular_component,integral component of membrane","-"]
["PHKB",5.282694824,1.967865387,1.423304496,5.451751555,{"v":3.65E-7,"d":"3.65E-07"},{"v":1.88E-6,"d":"1.88E-06"},"ENSG00000102893","K7CZU8,Phosphorylase b kinase regulatory subunit","XP_009429015.1,phosphorylase b kinase regulatory subunit beta isoform X1","PF00723,lycosyl hydrolases family 15","IPR008928,Six-hairpin glycosidase superfamily;IPR008734,Phosphorylase kinase alpha/beta subunit;IPR011613,Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family","KOG3635,Phosphorylase kinase;ENOG410XPJZ,-","GO:0005975,biological_process,carbohydrate metabolic process;GO:0016301,molecular_function,kinase activity;GO:0005977,biological_process,glycogen metabolic process;GO:0005516,molecular_function,calmodulin binding;GO:0003824,molecular_function,catalytic activity;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016310,biological_process,phosphorylation","-"]
["ZNF75A",2.621102931,0.975309771,1.422288475,3.938740793,0.000157241,0.0004566,"ENSG00000162086","H2QAG2,Zinc finger protein 75a","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["STT3A",9.569530702,3.568832622,1.421809096,5.619529167,{"v":1.59e-07,"d":"1.59E-07"},{"v":8.9e-07,"d":"8.90E-07"},"ENSG00000134910","H9EPJ5,Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A","NP_001244350.1,-","-","IPR003674,Oligosaccharyl transferase, STT3 subunit","KOG2292,Oligosaccharyltransferase, STT3 subunit;COG1287,Uncharacterized membrane protein, required for N-linked glycosylation","GO:0004576,molecular_function,oligosaccharyl transferase activity;GO:0006486,biological_process,protein glycosylation;GO:0016740,molecular_function,transferase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K07151,ko04141,Protein processing in endoplasmic reticulum;K07151,ko00513,Various types of N-glycan biosynthesis;K07151,ko00510,N-Glycan biosynthesis"]
["SRGAP3",0.652500928,0.242405846,1.4217867,3.20994691,2.254856E-3,0.005045522,"ENSG00000196220","G3R6F6,SLIT-ROBO Rho GTPase activating protein 3","-","PF00018,SH3 domain;PF00611,es/CIP4, and EFC/F-BAR homology domain;PF00620,RhoGAP domain","IPR035648,srGAP1/2/3, SH3 domain;IPR031160,F-BAR domain;IPR001060,FCH domain;IPR027267,AH/BAR domain superfamily;IPR008936,Rho GTPase activation protein;IPR001452,SH3 domain;IPR000198,Rho GTPase-activating protein domain;IPR036028,SH3-like domain superfamily","-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0007165,biological_process,signal transduction;GO:0005096,molecular_function,GTPase activator activity","K07526,ko04360,Axon guidance"]
["DBR1",3.907572011,1.451673491,1.4217867,3.20994691,2.254856E-3,0.005045522,"ENSG00000138231","H2QNG1,Debranching enzyme homolog 1","XP_526319.2,lariat debranching enzyme isoform X1","PF00149,Calcineurin-like phosphoesterase;PF05011,Lariat debranching enzyme, C-terminal domain","IPR004843,Calcineurin-like phosphoesterase domain, ApaH type;IPR007708,Lariat debranching enzyme, C-terminal","KOG2863,RNA lariat debranching enzyme;ENOG410XP0F,-","GO:0008419,molecular_function,RNA lariat debranching enzyme activity;GO:0016787,molecular_function,hydrolase activity;GO:0000375,biological_process,RNA splicing, via transesterification reactions;GO:0006397,biological_process,mRNA processing;GO:0016788,molecular_function,hydrolase activity, acting on ester bonds;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["FANCE",9.297578124,3.463944016,1.420926906,4.09946214,0.000110891,0.000332447,"ENSG00000112039","K7AR42,Fanconi anemia, complementation group E","-","PF11510,anconi Anaemia group E protein FANCE","-","-","-","-"]
["MIS18BP1",14.74152582,5.504745877,1.42023423,6.004345021,{"v":3.75e-08,"d":"3.75E-08"},{"v":2.43e-07,"d":"2.43E-07"},"ENSG00000129534","K7DLG2,MIS18 binding protein 1","-","PF09133,SANTA (SANT Associated);PF00249,Myb-like DNA-binding domain","IPR009057,Homeobox-like domain superfamily;IPR015216,SANT associated;IPR017884,SANT domain;IPR001005,SANT/Myb domain","ENOG410II9U,-;ENOG41120B5,-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["CAPN1",37.38118797,13.96896986,1.419792074,7.606383837,3.15E-10,{"v":3.25e-09,"d":"3.25E-09"},"ENSG00000014216","K7CEN7,Calpain 1,","XP_016776713.1,-;XP_016776712.1,-;XP_016776714.1,-;XP_016776711.1,-;XP_016776715.1,-;XP_016776710.1,-","PF00648,Calpain family cysteine protease;PF01067,Calpain large subunit, domain III;PF13833,-hand domain pair","IPR018247,EF-Hand 1, calcium-binding site;IPR000169,Cysteine peptidase, cysteine active site;IPR001300,Peptidase C2, calpain, catalytic domain;IPR022684,Peptidase C2, calpain family;IPR022683,Peptidase C2, calpain, domain III;IPR036213,Calpain large subunit, domain III superfamily;IPR029643,Calpain-1;IPR022682,Peptidase C2, calpain, large subunit, domain III;IPR002048,EF-hand domain;IPR033883,Calpain subdomain III;IPR011992,EF-hand domain pair","KOG0045,Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily);ENOG410XP0B,-","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0005509,molecular_function,calcium ion binding;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0005622,cellular_component,intracellular;GO:0004198,molecular_function,calcium-dependent cysteine-type endopeptidase activity;GO:0008233,molecular_function,peptidase activity","K01367,ko04141,Protein processing in endoplasmic reticulum;K01367,ko05010,Alzheimer's disease;K01367,ko04210,Apoptosis"]
["TADA2A",2.645912478,0.98519253,1.419715929,3.468469405,0.001006127,0.0024268,"ENSG00000276234","G7PUJ2,Transcriptional adapter","XP_005584001.1,-;XP_005584002.1,-","PF04433,SWIRM domain;PF00249,Myb-like DNA-binding domain","IPR016827,Transcriptional adaptor 2;IPR009057,Homeobox-like domain superfamily;IPR007526,SWIRM domain;IPR017884,SANT domain;IPR001005,SANT/Myb domain","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0031063,biological_process,regulation of histone deacetylation;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0090043,biological_process,regulation of tubulin deacetylation;GO:0005671,cellular_component,Ada2/Gcn5/Ada3 transcription activator complex;GO:0003713,molecular_function,transcription coactivator activity;GO:0072686,cellular_component,mitotic spindle;GO:0035065,biological_process,regulation of histone acetylation;GO:0000278,biological_process,mitotic cell cycle;GO:0006351,biological_process,transcription, DNA-templated;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0031647,biological_process,regulation of protein stability;GO:0005634,cellular_component,nucleus","-"]
["EAPP",19.88582497,7.424885948,1.419238394,4.838150876,{"v":5.48E-6,"d":"5.48E-06"},{"v":2.2e-05,"d":"2.20E-05"},"ENSG00000129518","G3QXQ7,E2F associated phosphoprotein","XP_004055116.1,E2F-associated phosphoprotein isoform X1","PF10238,2F-associated phosphoprotein","IPR019370,E2F-associated phosphoprotein","-","GO:0008284,biological_process,positive regulation of cell proliferation;GO:0034244,biological_process,negative regulation of transcription elongation from RNA polymerase II promoter;GO:0005634,cellular_component,nucleus;GO:0032968,biological_process,positive regulation of transcription elongation from RNA polymerase II promoter","-"]
["ARIH1",4.099508627,1.53234216,1.418826166,6.030162239,{"v":3.22e-08,"d":"3.22E-08"},{"v":2.12e-07,"d":"2.12E-07"},"ENSG00000166233","G1RUS6,Ariadne RBR E3 ubiquitin protein ligase 1","XP_003267228.1,E3 ubiquitin-protein ligase ARIH1","PF01485,IBR domain, a half RING-finger domain","IPR001841,Zinc finger, RING-type;IPR002867,IBR domain;IPR031127,E3 ubiquitin ligase RBR family;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XP9Y,-;KOG1815,Predicted E3 ubiquitin ligase","GO:0019005,cellular_component,SCF ubiquitin ligase complex;GO:0031464,cellular_component,Cul4A-RING E3 ubiquitin ligase complex;GO:0031624,molecular_function,ubiquitin conjugating enzyme binding;GO:0031462,cellular_component,Cul2-RING ubiquitin ligase complex;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0097413,cellular_component,Lewy body;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0031463,cellular_component,Cul3-RING ubiquitin ligase complex;GO:0005737,cellular_component,cytoplasm;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016567,biological_process,protein ubiquitination;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016604,cellular_component,nuclear body;GO:0008270,molecular_function,zinc ion binding","-"]
["PHLDB1",3.793327981,1.417934069,1.41866484,5.845956101,{"v":7.17E-8,"d":"7.17E-08"},{"v":4.35e-07,"d":"4.35E-07"},"ENSG00000019144","A0A024R3H6,Pleckstrin homology-like domain, family B, member 1, isoform CRA_b","NP_001138230.1,-;NP_055972.1,pleckstrin homology-like domain family B member 1 isoform a","PF00169,PH domain","IPR037810,PHLDB1/2/3, PH domain;IPR008984,SMAD/FHA domain superfamily;IPR001849,Pleckstrin homology domain;IPR000253,Forkhead-associated (FHA) domain;IPR011993,PH-like domain superfamily","ENOG41101DY,-;ENOG410ISGZ,-","-","-"]
["GLTP",35.75994769,13.36905748,1.418584765,6.069326765,{"v":3.21e-08,"d":"3.21E-08"},{"v":2.12e-07,"d":"2.12E-07"},"ENSG00000139433","K7B1F7,Glycolipid transfer protein","NP_001108230.1,-","PF08718,lycolipid transfer protein (GLTP)","IPR036497,Glycolipid transfer protein superfamily;IPR014830,Glycolipid transfer protein domain","KOG3221,Glycolipid transfer protein;ENOG410YFEA,-","GO:0005737,cellular_component,cytoplasm;GO:0120009,biological_process,intermembrane lipid transfer;GO:0120013,molecular_function,intermembrane lipid transfer activity","-"]
["CH17-360D5.2",7.122841812,2.656371667,1.418261368,3.687231609,0.00062469,1.577457E-3,"ENSG00000276850","Q8N8J2,cDNA FLJ39396 fis, clone PLACE6008640","XP_005276442.1,uncharacterized protein LOC107984085 isoform X1;XP_016854939.1,-","-","-","ENOG4110NV2,-;ENOG410KCKS,-","-","-"]
["PRRC2B",26.92747438,10.07539106,1.417992218,7.835341834,2.11E-10,{"v":2.25e-09,"d":"2.25E-09"},"ENSG00000130723","G3RXY1,Proline rich coiled-coil 2B","-","PF07001,BAT2 N-terminus","IPR009738,BAT2, N-terminal;IPR033184,Protein PRRC2","-","-","-"]
["FLII",116.2875205,43.53641134,1.417291516,9.015655987,{"v":3.81e-11,"d":"3.81E-11"},4.79E-10,"ENSG00000177731","K7AVA8,Flightless I homolog","-","PF13855,Leucine rich repeat;PF00626,elsolin repeat;PF12799,Leucine Rich repeats (2 copies)","IPR001611,Leucine-rich repeat;IPR007123,Gelsolin-like domain;IPR032675,Leucine-rich repeat domain superfamily;IPR029006,ADF-H/Gelsolin-like domain superfamily;IPR003591,Leucine-rich repeat, typical subtype;IPR025875,Leucine rich repeat 4;IPR007122,Villin/Gelsolin;IPR029919,Protein flightless-1","COG4886,Leucine-rich repeat (LRR) protein;KOG0444,Cytoskeletal regulator Flightless-I (contains leucine-rich and gelsolin repeats)","GO:0030036,biological_process,actin cytoskeleton organization;GO:0051015,molecular_function,actin filament binding;GO:0051014,biological_process,actin filament severing","-"]
["PLEK2",12.59146123,4.701346997,1.417183586,3.876891308,0.000262323,0.000723863,"ENSG00000100558","H2Q8H5,Pleckstrin 2","XP_510017.3,pleckstrin-2 isoform X1","PF00610,omain found in Dishevelled, Egl-10, and Pleckstrin (DEP);PF00169,PH domain","IPR036388,Winged helix-like DNA-binding domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR037370,Pleckstrin;IPR036390,Winged helix DNA-binding domain superfamily;IPR037369,Pleckstrin-2, DEP domain;IPR000591,DEP domain","ENOG410IGI2,-;ENOG410ZHY3,-","GO:0030036,biological_process,actin cytoskeleton organization;GO:0043325,molecular_function,phosphatidylinositol-3,4-bisphosphate binding;GO:0031346,biological_process,positive regulation of cell projection organization;GO:0035556,biological_process,intracellular signal transduction;GO:0005622,cellular_component,intracellular;GO:0080025,molecular_function,phosphatidylinositol-3,5-bisphosphate binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane","-"]
["IRGQ",4.523508695,1.693265346,1.415777542,4.980292828,{"v":2.86e-06,"d":"2.86E-06"},{"v":1.22E-5,"d":"1.22E-05"},"ENSG00000167378","B7ZMD6,IRGQ protein","-","-","IPR030385,IRG-type guanine nucleotide-binding (G) domain","ENOG410IH4F,-;ENOG41114NV,-","GO:0005525,molecular_function,GTP binding","-"]
["PRPF40B",2.966994615,1.110253096,1.415156598,4.329874015,{"v":4.1E-5,"d":"4.10E-05"},1.35582E-4,"ENSG00000110844","F8VU11,PRP40 pre-mRNA processing factor 40 homolog B","NP_001026868.2,pre-mRNA-processing factor 40 homolog B isoform 1","PF00397,WW domain;PF01846,domain","IPR002713,FF domain;IPR036020,WW domain superfamily;IPR036517,FF domain superfamily;IPR001202,WW domain","COG5104,Splicing factor;KOG0152,Spliceosomal protein FBP11/Splicing factor PRP40","-","-"]
["C11orf54",0.98484029,0.365870811,1.415086815,2.307315861,0.030635115,0.051243208,"ENSG00000182919","A0A024R396,Chromosome 11 open reading frame 54, isoform CRA_a","NP_001272997.1,-;XP_011541084.1,-;NP_001272996.1,-;XP_016873104.1,-;XP_016873103.1,-;XP_011541083.1,-;XP_016873102.1,-;XP_006718887.1,-;NP_001272998.1,ester hydrolase C11orf54 isoform a","PF08925,omain of Unknown Function (DUF1907)","IPR015021,Domain of unknown function DUF1907","-","GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["STXBP4",0.341953131,0.127036506,1.415086815,2.307315861,0.030635115,0.051243208,"ENSG00000166263","G3R8M4,Syntaxin binding protein 4","XP_004041357.2,syntaxin-binding protein 4","PF00397,WW domain;PF00595,PDZ domain (Also known as DHR or GLGF)","IPR001202,WW domain;IPR036020,WW domain superfamily;IPR036034,PDZ superfamily;IPR001478,PDZ domain","-","-","-"]
["LINC01547",2.324534555,0.863570827,1.415086815,2.307315861,0.030635115,0.051243208,"ENSG00000183250","G3REW6,Uncharacterized protein","-","-","-","-","-","-"]
["PTP4A3",2.145972811,0.79723466,1.415086815,2.307315861,0.030635115,0.051243208,"ENSG00000184489","A0A096MTG4,Protein tyrosine phosphatase type IVA, member 3","-","PF00782,ual specificity phosphatase, catalytic domain","-","-","-","-"]
["SENP3",20.2630931,7.593073291,1.414984676,5.70050724,{"v":1.25e-07,"d":"1.25E-07"},{"v":7.19e-07,"d":"7.19E-07"},"ENSG00000161956","G3R7B9,Uncharacterized protein","XP_018868596.1,sentrin-specific protease 3","PF02902,Ulp1 protease family, C-terminal catalytic domain","IPR003653,Ulp1 protease family, C-terminal catalytic domain;IPR037945,Sentrin-specific protease 3","-","GO:0006508,biological_process,proteolysis;GO:0005730,cellular_component,nucleolus;GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0016926,biological_process,protein desumoylation;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0071339,cellular_component,MLL1 complex;GO:0019538,biological_process,protein metabolic process","-"]
["ITGB1BP1",4.978200111,1.864511967,1.414336412,4.567900304,{"v":1.39e-05,"d":"1.39E-05"},{"v":5.14e-05,"d":"5.14E-05"},"ENSG00000119185","H2QHE8,Integrin beta 1 binding protein 1","XP_003308925.1,-","PF10480,Beta-1 integrin binding protein","IPR019517,Integrin binding protein, ICAP-1;IPR011993,PH-like domain superfamily","ENOG4111GWT,-;ENOG410IFN6,-","GO:0007229,biological_process,integrin-mediated signaling pathway","-"]
["ACTR1A",14.08229482,5.280352037,1.413914639,5.52247925,{"v":2.64e-07,"d":"2.64E-07"},{"v":1.41e-06,"d":"1.41E-06"},"ENSG00000138107","A0A091DPY8,Alpha-centractin","XP_010624734.1,-","PF00022,Actin","IPR004001,Actin, conserved site;IPR029909,Actin-related protein 1 family;IPR004000,Actin family;IPR020902,Actin/actin-like conserved site","-","GO:0005869,cellular_component,dynactin complex;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["NHLRC2",3.427652458,1.284611208,1.413739086,4.7720196,{"v":5.46e-06,"d":"5.46E-06"},{"v":2.2e-05,"d":"2.20E-05"},"ENSG00000196865","H2Q2L4,NHL repeat containing 2","XP_508046.2,NHL repeat-containing protein 2 isoform X1","PF01436,NHL repeat;PF13905,Thioredoxin-like","IPR001258,NHL repeat;IPR036249,Thioredoxin-like superfamily;IPR011042,Six-bladed beta-propeller, TolB-like;IPR013766,Thioredoxin domain;IPR013017,NHL repeat, subgroup;IPR012336,Thioredoxin-like fold","ENOG410XTIR,-;ENOG410ITFZ,-","GO:0045454,biological_process,cell redox homeostasis;GO:0005623,cellular_component,cell","-"]
["RP11-123K3.9",12.53355974,4.674228888,1.413560673,2.761690158,0.008342081,0.016217577,"ENSG00000276727","B4DWA7,Serine hydroxymethyltransferase","-","PF00464,Serine hydroxymethyltransferase","IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR015422,Pyridoxal phosphate-dependent transferase domain 1;IPR019798,Serine hydroxymethyltransferase, pyridoxal phosphate binding site;IPR015424,Pyridoxal phosphate-dependent transferase;IPR001085,Serine hydroxymethyltransferase","COG0112,Glycine/serine hydroxymethyltransferase;KOG2467,Glycine/serine hydroxymethyltransferase","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0004372,molecular_function,glycine hydroxymethyltransferase activity;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0035999,biological_process,tetrahydrofolate interconversion;GO:0006730,biological_process,one-carbon metabolic process;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0019264,biological_process,glycine biosynthetic process from serine","-"]
["FOXJ2",6.524873751,2.446026353,1.413497416,4.864143887,{"v":4.62e-06,"d":"4.62E-06"},{"v":1.89e-05,"d":"1.89E-05"},"ENSG00000065970","H2Q5D1,Forkhead box J2","XP_001166729.1,forkhead box protein J2 isoform X1","PF00250,orkhead domain","IPR030456,Fork head domain conserved site 2;IPR036390,Winged helix DNA-binding domain superfamily;IPR001766,Fork head domain;IPR036388,Winged helix-like DNA-binding domain superfamily","KOG2294,Transcription factor of the Forkhead/HNF3 family;COG5025,Transcription factor of the Forkhead/HNF3 family","GO:0016525,biological_process,negative regulation of angiogenesis;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0009653,biological_process,anatomical structure morphogenesis;GO:0003677,molecular_function,DNA binding;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:1904707,biological_process,positive regulation of vascular smooth muscle cell proliferation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0001650,cellular_component,fibrillar center;GO:0030154,biological_process,cell differentiation;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0110059,biological_process,negative regulation of blood vessel endothelial cell differentiation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated","-"]
["ACAT1",2.041204687,0.762826788,1.412732582,3.105242425,0.003238274,0.006933681,"ENSG00000075239","H2Q4P9,Acetyl-CoA acetyltransferase 1","XP_508738.2,-","PF00108,Thiolase, N-terminal domain;PF02803,Thiolase, C-terminal domain","IPR016039,Thiolase-like;IPR020610,Thiolase, active site;IPR020615,Thiolase, acyl-enzyme intermediate active site;IPR020613,Thiolase, conserved site;IPR020617,Thiolase, C-terminal;IPR002155,Thiolase;IPR020616,Thiolase, N-terminal","COG0183,Acetyl-CoA acetyltransferase;KOG1390,Acetyl-CoA acetyltransferase","GO:0016747,molecular_function,transferase activity, transferring acyl groups other than amino-acyl groups;GO:0016830,molecular_function,carbon-carbon lyase activity;GO:0016885,molecular_function,ligase activity, forming carbon-carbon bonds;GO:0046952,biological_process,ketone body catabolic process;GO:0006550,biological_process,isoleucine catabolic process;GO:0015936,biological_process,coenzyme A metabolic process;GO:0006085,biological_process,acetyl-CoA biosynthetic process;GO:0046356,biological_process,acetyl-CoA catabolic process;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0006635,biological_process,fatty acid beta-oxidation;GO:1902860,biological_process,propionyl-CoA biosynthetic process;GO:0003985,molecular_function,acetyl-CoA C-acetyltransferase activity;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0015937,biological_process,coenzyme A biosynthetic process","K00626,ko00640,Propanoate metabolism;K00626,ko00630,Glyoxylate and dicarboxylate metabolism;K00626,ko00900,Terpenoid backbone biosynthesis;K00626,ko00362,Benzoate degradation;K00626,ko00072,Synthesis and degradation of ketone bodies;K00626,ko00620,Pyruvate metabolism;K00626,ko01212,Fatty acid metabolism;K00626,ko00720,Carbon fixation pathways in prokaryotes;K00626,ko00310,Lysine degradation;K00626,ko00650,Butanoate metabolism;K00626,ko02020,Two-component system;K00626,ko00280,Valine, leucine and isoleucine degradation;K00626,ko01200,Carbon metabolism;K00626,ko00071,Fatty acid degradation;K00626,ko00380,Tryptophan metabolism"]
["CCDC109B",3.196322763,1.194510596,1.412732582,3.105242425,0.003238274,0.006933681,"ENSG00000005059","H2QQ08,Coiled-coil domain containing 109B","XP_517392.2,calcium uniporter regulatory subunit MCUb, mitochondrial isoform X1","PF04678,Mitochondrial calcium uniporter","IPR006769,Coiled-coil domain containing protein 109, C-terminal","ENOG410Y3YU,-;KOG2966,Uncharacterized conserved protein","GO:0006851,biological_process,mitochondrial calcium ion transmembrane transport;GO:0031305,cellular_component,integral component of mitochondrial inner membrane;GO:0016021,cellular_component,integral component of membrane;GO:0051560,biological_process,mitochondrial calcium ion homeostasis;GO:0005262,molecular_function,calcium channel activity;GO:0036444,biological_process,calcium import into the mitochondrion;GO:1990246,cellular_component,uniplex complex;GO:0065009,biological_process,regulation of molecular function;GO:0015292,molecular_function,uniporter activity;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0019855,molecular_function,calcium channel inhibitor activity;GO:0034704,cellular_component,calcium channel complex;GO:0031224,cellular_component,intrinsic component of membrane","-"]
["RP11-442H21.2",186.4356513,70.02016949,1.412312681,6.775388999,{"v":2.96e-09,"d":"2.96E-09"},{"v":2.44E-8,"d":"2.44E-08"},"ENSG00000269926","F6X5P2,DNA damage inducible transcript 4","XP_002756301.1,DNA damage-inducible transcript 4 protein","PF07809,RTP801 C-terminal region","IPR038281,RTP801-like, C-terminal domain superfamily;IPR012918,RTP801-like","ENOG4111N0W,-;ENOG410IIEE,-","GO:0045820,biological_process,negative regulation of glycolytic process;GO:0051607,biological_process,defense response to virus;GO:0009968,biological_process,negative regulation of signal transduction;GO:0032007,biological_process,negative regulation of TOR signaling;GO:0005737,cellular_component,cytoplasm;GO:0071549,biological_process,cellular response to dexamethasone stimulus;GO:0071889,molecular_function,14-3-3 protein binding;GO:0005739,cellular_component,mitochondrion;GO:0005622,cellular_component,intracellular;GO:0005829,cellular_component,cytosol;GO:0072593,biological_process,reactive oxygen species metabolic process;GO:0001666,biological_process,response to hypoxia;GO:0042771,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator","K08270,ko04150,mTOR signaling pathway;K08270,ko04151,PI3K-Akt signaling pathway;K08270,ko05206,MicroRNAs in cancer"]
["WDR47",3.758130267,1.407552669,1.411856077,3.613148911,0.000535418,1.378858E-3,"ENSG00000085433","G3QLX8,WD repeat domain 47","XP_018865295.1,WD repeat-containing protein 47 isoform X3","PF12894,Anaphase-promoting complex subunit 4 WD40 domain;PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR006594,LIS1 homology motif;IPR024977,Anaphase-promoting complex subunit 4, WD40 domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR006595,CTLH, C-terminal LisH motif;IPR001680,WD40 repeat","-","-","-"]
["THAP4",5.28192252,1.978266748,1.411856077,3.613148911,0.000535418,1.378858E-3,"ENSG00000176946","H2QJR7,THAP domain containing 4","-","PF08768,omain of unknown function (DUF1794);PF05485,THAP domain","IPR038441,THAP-type zinc finger superfamily;IPR014878,Domain of unknown function DUF1794;IPR006612,THAP-type zinc finger;IPR012674,Calycin","KOG3371,Uncharacterized conserved protein;ENOG4111TBC,-","GO:0003676,molecular_function,nucleic acid binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0003677,molecular_function,DNA binding;GO:0020037,molecular_function,heme binding","-"]
["ADAM22",1.576708892,0.590916943,1.411596155,3.812239476,0.00034774,0.000932853,"ENSG00000008277","H2RBY3,Uncharacterized protein","XP_001164271.1,disintegrin and metalloproteinase domain-containing protein 22 isoform X17;XP_016813181.1,-","PF00200,isintegrin;PF08516,ADAM cysteine-rich;PF01562,Reprolysin family propeptide;PF01421,Reprolysin (M12B) family zinc metalloprotease;PF07974,-like domain","IPR001590,Peptidase M12B, ADAM/reprolysin;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR001762,Disintegrin domain;IPR034027,Reprolysin domain, adamalysin-type;IPR013032,EGF-like, conserved site;IPR006586,ADAM, cysteine-rich;IPR013111,EGF-like domain, extracellular;IPR018358,Disintegrin, conserved site;IPR036436,Disintegrin domain superfamily;IPR002870,Peptidase M12B, propeptide","ENOG410XX2M,-;KOG3607,Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family","GO:0008237,molecular_function,metallopeptidase activity;GO:0006508,biological_process,proteolysis;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["AK3",4.290491137,1.607984785,1.411596155,3.812239476,0.00034774,0.000932853,"ENSG00000147853","G3S5H3,GTP:AMP phosphotransferase AK3, mitochondrial","XP_004047811.1,-","PF00406,Adenylate kinase;PF05191,Adenylate kinase, active site lid","IPR007862,Adenylate kinase, active site lid domain;IPR006259,Adenylate kinase subfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR000850,Adenylate kinase/UMP-CMP kinase;IPR036193,Adenylate kinase, active site lid domain superfamily;IPR028586,Adenylate kinase 3/4, mitochondrial;IPR033690,Adenylate kinase, conserved site","-","GO:0016301,molecular_function,kinase activity;GO:0006172,biological_process,ADP biosynthetic process;GO:0016310,biological_process,phosphorylation;GO:0046039,biological_process,GTP metabolic process;GO:0046939,biological_process,nucleotide phosphorylation;GO:0046899,molecular_function,nucleoside triphosphate adenylate kinase activity;GO:0046041,biological_process,ITP metabolic process;GO:0016740,molecular_function,transferase activity;GO:0004017,molecular_function,adenylate kinase activity;GO:0005524,molecular_function,ATP binding;GO:0046033,biological_process,AMP metabolic process;GO:0005525,molecular_function,GTP binding;GO:0019205,molecular_function,nucleobase-containing compound kinase activity;GO:0005759,cellular_component,mitochondrial matrix;GO:0005739,cellular_component,mitochondrion;GO:0006139,biological_process,nucleobase-containing compound metabolic process;GO:0000166,molecular_function,nucleotide binding;GO:0046051,biological_process,UTP metabolic process;GO:0016776,molecular_function,phosphotransferase activity, phosphate group as acceptor","K00944,ko00230,Purine metabolism"]
["MID1IP1",5.764204054,2.161368371,1.411398322,3.986958212,0.000233414,6.50897E-4,"ENSG00000165175","G1QKZ2,MID1 interacting protein 1","-","PF07084,Thyroid hormone-inducible hepatic protein Spot 14","-","-","-","-"]
["ASAP3",4.903447266,1.839329684,1.411242704,4.142647107,{"v":8.65e-05,"d":"8.65E-05"},0.000264501,"ENSG00000088280","A0A024RAB1,Development and differentiation enhancing factor-like 1, isoform CRA_a","NP_060177.2,arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform a","PF12796,Ankyrin repeats (3 copies);PF01412,Putative GTPase activating protein for Arf;PF16746,BAR domain of APPL family;PF00169,PH domain","IPR037278,ARFGAP/RecO-like zinc finger;IPR038508,ArfGAP domain superfamily;IPR028775,Arf GTPase activating protein, ASAP3;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR027267,AH/BAR domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR001164,Arf GTPase activating protein;IPR002110,Ankyrin repeat;IPR037844,ASAP, PH domain","COG5347,GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport;KOG0521,Putative GTPase activating proteins (GAPs)","GO:0046872,molecular_function,metal ion binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0005829,cellular_component,cytosol;GO:0016477,biological_process,cell migration;GO:0005925,cellular_component,focal adhesion;GO:0005654,cellular_component,nucleoplasm","K12488,ko04144,Endocytosis;K12488,ko04666,Fc gamma R-mediated phagocytosis"]
["CCNG1",9.587376667,3.598371167,1.41101357,4.410940996,{"v":2.64e-05,"d":"2.64E-05"},{"v":9.13e-05,"d":"9.13E-05"},"ENSG00000113328","G1QXI2,Cyclin G1","XP_003268672.1,-","PF00134,Cyclin, N-terminal domain","IPR028860,Cyclin-G1;IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","COG5024,Cyclin;KOG0653,Cyclin B and related kinase-activating proteins","GO:0051726,biological_process,regulation of cell cycle","K10145,ko05206,MicroRNAs in cancer;K10145,ko04115,p53 signaling pathway"]
["PDXDC1",36.94385257,13.8934872,1.410688622,7.907720849,{"v":2.37e-10,"d":"2.37E-10"},{"v":2.5e-09,"d":"2.50E-09"},"ENSG00000179889","H3BND4,Pyridoxal-dependent decarboxylase domain-containing protein 1","XP_005255230.1,pyridoxal-dependent decarboxylase domain-containing protein 1 isoform X2;XP_006725286.1,-;XP_006726658.1,-","PF00282,Pyridoxal-dependent decarboxylase conserved domain","IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR002129,Pyridoxal phosphate-dependent decarboxylase;IPR015424,Pyridoxal phosphate-dependent transferase","KOG0630,Predicted pyridoxal-dependent decarboxylase;ENOG410XYFU,-","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0005794,cellular_component,Golgi apparatus;GO:0016831,molecular_function,carboxy-lyase activity;GO:0003824,molecular_function,catalytic activity;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0019752,biological_process,carboxylic acid metabolic process","-"]
["SPRR3",65.9153769,24.78509057,1.410275522,6.050327591,{"v":4.22e-08,"d":"4.22E-08"},{"v":2.7e-07,"d":"2.70E-07"},"-","-","-","-","-","-","-","-"]
["TUBB6",32.5880452,12.25653887,1.410177491,6.542953457,{"v":7.19e-09,"d":"7.19E-09"},{"v":5.47E-8,"d":"5.47E-08"},"ENSG00000176014","G3QLA2,Tubulin beta chain","XP_004059247.1,-","PF03953,Tubulin C-terminal domain;PF00091,Tubulin/FtsZ family, GTPase domain","IPR017975,Tubulin, conserved site;IPR018316,Tubulin/FtsZ, 2-layer sandwich domain;IPR003008,Tubulin/FtsZ, GTPase domain;IPR008280,Tubulin/FtsZ, C-terminal;IPR036525,Tubulin/FtsZ, GTPase domain superfamily;IPR037103,Tubulin/FtsZ, C-terminal domain superfamily;IPR013838,Beta tubulin, autoregulation binding site;IPR000217,Tubulin;IPR023123,Tubulin, C-terminal;IPR002453,Beta tubulin","-","GO:0005874,cellular_component,microtubule;GO:0005737,cellular_component,cytoplasm;GO:0007010,biological_process,cytoskeleton organization;GO:0007017,biological_process,microtubule-based process;GO:0005856,cellular_component,cytoskeleton;GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005200,molecular_function,structural constituent of cytoskeleton","K07375,ko04540,Gap junction;K07375,ko05130,Pathogenic Escherichia coli infection;K07375,ko04145,Phagosome"]
["NR2C2",5.303229706,1.995750617,1.408628337,5.460943095,{"v":4.23e-07,"d":"4.23E-07"},{"v":2.16e-06,"d":"2.16E-06"},"ENSG00000177463","G7N7T5,Nuclear receptor subfamily 2 group C member 2","XP_014985665.1,-","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR001628,Zinc finger, nuclear hormone receptor-type;IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR013088,Zinc finger, NHR/GATA-type","KOG3575,FOG: Hormone receptors;ENOG410XRZC,-","GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway","-"]
["CASC3",39.67594277,14.94515086,1.408262501,7.452738234,{"v":6.33e-10,"d":"6.33E-10"},{"v":6.11e-09,"d":"6.11E-09"},"ENSG00000108349","K7CMY7,Cancer susceptibility candidate 3","-","PF09405,CASC3/Barentsz eIF4AIII binding","IPR028544,Protein CASC3;IPR018545,Btz domain","ENOG410ZW5Y,-;KOG4264,Nucleo-cytoplasmic protein MLN51","GO:0003723,molecular_function,RNA binding;GO:0035145,cellular_component,exon-exon junction complex;GO:0006397,biological_process,mRNA processing","-"]
["CTSA",5.798634012,2.182184829,1.407520705,4.599204794,{"v":1.39e-05,"d":"1.39E-05"},{"v":5.11e-05,"d":"5.11E-05"},"ENSG00000064601","X6R8A1,Carboxypeptidase","NP_000299.2,lysosomal protective protein isoform a precursor","PF00450,Serine carboxypeptidase","IPR018202,Serine carboxypeptidase, serine active site;IPR001563,Peptidase S10, serine carboxypeptidase;IPR029058,Alpha/Beta hydrolase fold;IPR033124,Serine carboxypeptidases, histidine active site","KOG1282,Serine carboxypeptidases (lysosomal cathepsin A);COG2939,Carboxypeptidase C (cathepsin A)","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0004185,molecular_function,serine-type carboxypeptidase activity;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0004180,molecular_function,carboxypeptidase activity;GO:0008233,molecular_function,peptidase activity;GO:0005765,cellular_component,lysosomal membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["CALHM2",8.404316596,3.162774566,1.406796726,4.234664911,{"v":8.01e-05,"d":"8.01E-05"},0.000247444,"ENSG00000138172","K7CBV8,Calcium homeostasis modulator 2","-","PF14798,Calcium homeostasis modulator","IPR029570,Calcium homeostasis modulator protein 2;IPR029569,Calcium homeostasis modulator family","ENOG410IJ7Y,-;ENOG410XQ8H,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TMEM57",5.908156417,2.22340111,1.406448429,4.089168818,0.000110891,0.000332447,"ENSG00000204178","H9FWL6,Macoilin","-","PF09726,Macoilin family","IPR019130,Macoilin","KOG1821,Uncharacterized conserved protein;ENOG410XRFG,-","GO:0030867,cellular_component,rough endoplasmic reticulum membrane;GO:0030424,cellular_component,axon;GO:0044306,cellular_component,neuron projection terminus;GO:0023041,biological_process,neuronal signal transduction;GO:0043005,cellular_component,neuron projection;GO:0016020,cellular_component,membrane;GO:0031965,cellular_component,nuclear membrane;GO:0007420,biological_process,brain development;GO:0045202,cellular_component,synapse;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","-"]
["MEGF8",1.837538936,0.69151624,1.40601332,3.927198891,0.000199275,0.000565995,"ENSG00000105429","H2QGG4,Uncharacterized protein","XP_003953558.2,multiple epidermal growth factor-like domains protein 8 isoform X4","PF00053,Laminin EGF domain;PF01437,Plexin repeat;PF00431,CUB domain;PF13418,alactose oxidase, central domain;PF12947,domain;PF07645,Calcium-binding EGF domain","IPR024731,EGF domain;IPR035914,Spermadhesin, CUB domain superfamily;IPR018097,EGF-like calcium-binding, conserved site;IPR016201,PSI domain;IPR002165,Plexin repeat;IPR015915,Kelch-type beta propeller;IPR001881,EGF-like calcium-binding domain;IPR000859,CUB domain;IPR002049,Laminin EGF domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site","KOG1388,Attractin and platelet-activating factor acetylhydrolase;ENOG410YF0N,-","GO:0097094,biological_process,craniofacial suture morphogenesis;GO:0005509,molecular_function,calcium ion binding;GO:0005634,cellular_component,nucleus;GO:0060971,biological_process,embryonic heart tube left/right pattern formation;GO:0060976,biological_process,coronary vasculature development;GO:0071907,biological_process,determination of digestive tract left/right asymmetry;GO:0048704,biological_process,embryonic skeletal system morphogenesis;GO:0030509,biological_process,BMP signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0060972,biological_process,left/right pattern formation;GO:0061371,biological_process,determination of heart left/right asymmetry;GO:0097155,biological_process,fasciculation of sensory neuron axon;GO:0048842,biological_process,positive regulation of axon extension involved in axon guidance;GO:0035108,biological_process,limb morphogenesis;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0016020,cellular_component,membrane;GO:0010468,biological_process,regulation of gene expression;GO:0007368,biological_process,determination of left/right symmetry;GO:0045879,biological_process,negative regulation of smoothened signaling pathway;GO:0042074,biological_process,cell migration involved in gastrulation;GO:0003143,biological_process,embryonic heart tube morphogenesis;GO:0055113,biological_process,epiboly involved in gastrulation with mouth forming second","-"]
["MOB3B",2.579995934,0.970923148,1.405454321,3.744517469,4.64327E-4,1.208345E-3,"ENSG00000120162","A0A0P6JV62,MOB kinase activator 3B","XP_004838428.1,-","PF03637,Mob1/phocein family","IPR036703,MOB kinase activator superfamily;IPR005301,MOB kinase activator family","-","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation","-"]
["SLC4A2",4.692888247,1.769986989,1.404439157,4.666730814,{"v":1.36E-5,"d":"1.36E-05"},{"v":5.01e-05,"d":"5.01E-05"},"ENSG00000164889","Q59GF1,Anion exchange protein","NP_001186622.1,anion exchange protein 2 isoform 2;NP_001186623.1,anion exchange protein 2 isoform 3;NP_001186621.1,-","PF07565,Band 3 cytoplasmic domain;PF00955,HCO3- transporter family","IPR016152,Phosphotransferase/anion transporter;IPR003020,Bicarbonate transporter, eukaryotic;IPR001717,Anion exchange protein;IPR011531,Bicarbonate transporter, C-terminal;IPR002978,Anion exchange protein 2;IPR013769,Band 3 cytoplasmic domain;IPR018241,Anion exchange, conserved site","KOG1172,Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family);ENOG410XPHD,-","GO:0008509,molecular_function,anion transmembrane transporter activity;GO:0005452,molecular_function,inorganic anion exchanger activity;GO:0015698,biological_process,inorganic anion transport;GO:0098656,biological_process,anion transmembrane transport;GO:0006811,biological_process,ion transport;GO:0016020,cellular_component,membrane;GO:0006820,biological_process,anion transport;GO:0016021,cellular_component,integral component of membrane","K13855,ko04971,Gastric acid secretion;K13855,ko04970,Salivary secretion;K13855,ko04972,Pancreatic secretion;K13855,ko04976,Bile secretion"]
["RP11-196H14.2",19.46394633,7.324816209,1.403668737,3.289313268,2.576311E-3,0.005667883,"ENSG00000255886","A0A1A6H2Y6,Uncharacterized protein","-","PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR031160,F-BAR domain;IPR000198,Rho GTPase-activating protein domain;IPR027267,AH/BAR domain superfamily;IPR036028,SH3-like domain superfamily","-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0007165,biological_process,signal transduction;GO:0005096,molecular_function,GTPase activator activity","-"]
["CDYL2",1.526271823,0.574377898,1.403668737,3.289313268,2.576311E-3,0.005667883,"ENSG00000166446","A0A0B4J291,Chromodomain Y-like protein 2","-","PF00385,Chromo (CHRromatin Organisation MOdifier) domain;PF00378,noyl-CoA hydratase/isomerase","IPR023780,Chromo domain;IPR016197,Chromo-like domain superfamily;IPR023779,Chromo domain, conserved site;IPR014748,Enoyl-CoA hydratase, C-terminal;IPR001753,Enoyl-CoA hydratase/isomerase;IPR029045,ClpP/crotonase-like domain superfamily;IPR000953,Chromo/chromo shadow domain","COG1024,Enoyl-CoA hydratase/carnithine racemase;KOG0016,Enoyl-CoA hydratase/isomerase;KOG1911,Heterochromatin-associated protein HP1 and related CHROMO domain proteins","GO:0003824,molecular_function,catalytic activity;GO:0005634,cellular_component,nucleus;GO:0008152,biological_process,metabolic process","-"]
["CTB-39G8.3",28.57835447,10.75481767,1.403668737,3.289313268,2.576311E-3,0.005667883,"ENSG00000267344","A0A0G2JRG8,Rho GTPase-activating protein 27","-","PF00397,WW domain;PF00620,RhoGAP domain;PF00169,PH domain","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR001202,WW domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR008936,Rho GTPase activation protein;IPR001452,SH3 domain;IPR036020,WW domain superfamily;IPR000198,Rho GTPase-activating protein domain","-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0007165,biological_process,signal transduction;GO:0005096,molecular_function,GTPase activator activity","-"]
["WDR6",5.730561575,2.162183367,1.403496912,4.445812576,{"v":3.82E-5,"d":"3.82E-05"},0.000127177,"ENSG00000178252","A0A087X295,WD repeat-containing protein 6","NP_060501.3,WD repeat-containing protein 6 isoform 1","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","KOG0974,WD-repeat protein WDR6, WD repeat superfamily;ENOG410ZJ6J,-","GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane;GO:0043560,molecular_function,insulin receptor substrate binding","-"]
["SHMT1",10.59944338,4.005225465,1.402974621,5.757062853,{"v":1.39e-07,"d":"1.39E-07"},{"v":7.88e-07,"d":"7.88E-07"},"ENSG00000176974","H2QCE4,Serine hydroxymethyltransferase","XP_016785996.1,serine hydroxymethyltransferase, cytosolic isoform X2","PF00464,Serine hydroxymethyltransferase","IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR015422,Pyridoxal phosphate-dependent transferase domain 1;IPR019798,Serine hydroxymethyltransferase, pyridoxal phosphate binding site;IPR015424,Pyridoxal phosphate-dependent transferase;IPR001085,Serine hydroxymethyltransferase","COG0112,Glycine/serine hydroxymethyltransferase;KOG2467,Glycine/serine hydroxymethyltransferase","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0004372,molecular_function,glycine hydroxymethyltransferase activity;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0006730,biological_process,one-carbon metabolic process;GO:0019264,biological_process,glycine biosynthetic process from serine;GO:0035999,biological_process,tetrahydrofolate interconversion","-"]
["SOGA1",3.782912151,1.429520583,1.402538927,5.333665499,{"v":8.65e-07,"d":"8.65E-07"},{"v":4.14e-06,"d":"4.14E-06"},"ENSG00000149639","G3REI8,Suppressor of glucose, autophagy associated 1","-","PF14818,omain of unknown function (DUF4482);PF11365,Protein SOGA","IPR027881,Protein SOGA;IPR027882,Domain of unknown function DUF4482","-","GO:0010506,biological_process,regulation of autophagy;GO:0005615,cellular_component,extracellular space","-"]
["HECA",7.10603926,2.684809133,1.402179512,4.825924135,{"v":6.5e-06,"d":"6.50E-06"},{"v":2.58E-5,"d":"2.58E-05"},"ENSG00000112406","H2QTU3,Uncharacterized protein","-","PF15353,Headcase protein family homologue;PF16002,Headcase protein","IPR026066,Headcase protein;IPR031947,Headcase, middle domain","KOG3816,Cell differentiation regulator of the Headcase family;ENOG410XREE,-","GO:0005737,cellular_component,cytoplasm;GO:0045930,biological_process,negative regulation of mitotic cell cycle;GO:0005634,cellular_component,nucleus","-"]
["RP11-498C9.12",18.55816411,6.983945543,1.402110356,2.992186977,0.00630869,0.012640158,"ENSG00000264769","T0M314,Transcription factor MafG-like protein","-","PF03131,bZIP Maf transcription factor","IPR024874,Transcription factor Maf family;IPR028551,Transcription factor MafG;IPR008917,Transcription factor, Skn-1-like, DNA-binding domain superfamily;IPR004826,Basic leucine zipper domain, Maf-type;IPR004827,Basic-leucine zipper domain","-","GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005634,cellular_component,nucleus","-"]
["NT5C2",21.00112999,7.943741395,1.401823014,6.239254502,{"v":2.07E-8,"d":"2.07E-08"},{"v":1.41e-07,"d":"1.41E-07"},"ENSG00000076685","F6RKD1,5'-nucleotidase, cytosolic II","XP_017834766.1,-;XP_009008460.1,cytosolic purine 5'-nucleotidase isoform X2","PF05761,5' nucleotidase family","IPR008380,HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR016695,Purine 5'-nucleotidase","KOG2469,IMP-GMP specific 5'-nucleotidase;ENOG410XQAV,-","GO:0046872,molecular_function,metal ion binding","-"]
["EIF2D",4.623169991,1.747213311,1.401637861,4.731226701,{"v":9.34e-06,"d":"9.34E-06"},{"v":3.58e-05,"d":"3.58E-05"},"ENSG00000143486","K7C945,Eukaryotic translation initiation factor 2D","-","PF01253,Translation initiation factor SUI1","IPR015947,PUA-like superfamily;IPR036885,SWIB/MDM2 domain superfamily;IPR001950,SUI1 domain;IPR002478,PUA domain;IPR036877,SUI1 domain superfamily;IPR036974,PUA domain superfamily","KOG2522,Filamentous baseplate protein Ligatin, contains PUA domain;ENOG410XSAV,-","GO:0003723,molecular_function,RNA binding;GO:0003743,molecular_function,translation initiation factor activity;GO:0006413,biological_process,translational initiation","-"]
["TWF1",24.8813784,9.416574083,1.400959171,6.094891057,{"v":3.79e-08,"d":"3.79E-08"},{"v":2.46e-07,"d":"2.46E-07"},"ENSG00000151239","F6PNP1,Twinfilin actin binding protein 1","-","PF00241,Cofilin/tropomyosin-type actin-binding protein","IPR002108,Actin-depolymerising factor homology domain;IPR028458,Twinfilin;IPR029006,ADF-H/Gelsolin-like domain superfamily","ENOG410XS1J,-;KOG1747,Protein tyrosine kinase 9/actin monomer-binding protein","GO:0005546,molecular_function,phosphatidylinositol-4,5-bisphosphate binding;GO:0005911,cellular_component,cell-cell junction;GO:0030016,cellular_component,myofibril;GO:0030175,cellular_component,filopodium;GO:0042989,biological_process,sequestering of actin monomers;GO:0015629,cellular_component,actin cytoskeleton;GO:0005622,cellular_component,intracellular;GO:0051016,biological_process,barbed-end actin filament capping;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0032587,cellular_component,ruffle membrane;GO:0005524,molecular_function,ATP binding;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0010613,biological_process,positive regulation of cardiac muscle hypertrophy;GO:0003785,molecular_function,actin monomer binding;GO:0003779,molecular_function,actin binding;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol;GO:0030837,biological_process,negative regulation of actin filament polymerization;GO:0043538,biological_process,regulation of actin phosphorylation;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation","-"]
["DSTYK",3.84424027,1.453837087,1.400290916,4.520756026,{"v":2.51E-5,"d":"2.51E-05"},{"v":8.72e-05,"d":"8.72E-05"},"ENSG00000133059","H2N406,Dual serine/threonine and tyrosine protein kinase","-","PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR017441,Protein kinase, ATP binding site;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0192,Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs","GO:0044344,biological_process,cellular response to fibroblast growth factor stimulus;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0016324,cellular_component,apical plasma membrane;GO:0016323,cellular_component,basolateral plasma membrane;GO:0033674,biological_process,positive regulation of kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0045743,biological_process,positive regulation of fibroblast growth factor receptor signaling pathway;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding","-"]
["MMP14",12.0219518,4.550881182,1.399936017,5.243620852,{"v":1.26E-6,"d":"1.26E-06"},{"v":5.82e-06,"d":"5.82E-06"},"ENSG00000157227","K4RH61,Matrix metalloproteinase 14","-","PF00413,Matrixin;PF01471,Putative peptidoglycan binding domain;PF11857,omain of unknown function (DUF3377);PF00045,Hemopexin","IPR001818,Peptidase M10, metallopeptidase;IPR018486,Hemopexin, conserved site;IPR036375,Hemopexin-like domain superfamily;IPR036365,PGBD-like superfamily;IPR021190,Peptidase M10A;IPR000585,Hemopexin-like domain;IPR036366,PGBD superfamily;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR006026,Peptidase, metallopeptidase;IPR021805,Peptidase M10A, matrix metallopeptidase, C-terminal;IPR018487,Hemopexin-like repeats;IPR028693,Matrix metalloproteinase-14;IPR033739,Peptidase M10A, catalytic domain;IPR021158,Peptidase M10A, cysteine switch, zinc binding site;IPR002477,Peptidoglycan binding-like","KOG1565,Gelatinase A and related matrix metalloproteases;ENOG410XQ5D,-","GO:0030307,biological_process,positive regulation of cell growth;GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0008237,molecular_function,metallopeptidase activity;GO:0031012,cellular_component,extracellular matrix;GO:0046872,molecular_function,metal ion binding;GO:0016021,cellular_component,integral component of membrane;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0016020,cellular_component,membrane;GO:0008270,molecular_function,zinc ion binding;GO:0008233,molecular_function,peptidase activity;GO:0030335,biological_process,positive regulation of cell migration","-"]
["AVPI1",5.378301163,2.024002063,1.399521324,2.61597788,0.012664137,0.023547539,"ENSG00000119986","G3RMY3,Uncharacterized protein","XP_004049950.1,arginine vasopressin-induced protein 1","PF15063,Thyroid cancer protein 1","IPR020282,Arginine vasopressin-induced protein 1/transcriptional and immune response regulator","-","GO:0000187,biological_process,activation of MAPK activity","-"]
["PRR7",4.422226182,1.664204856,1.399521324,2.61597788,0.012664137,0.023547539,"ENSG00000131188","K7CQ48,Proline rich 7","XP_016809852.1,-","-","-","ENOG410YRB8,-;ENOG410IWCG,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NFKB1",4.705938631,1.780494987,1.399439072,4.402689702,{"v":3.23e-05,"d":"3.23E-05"},1.09456E-4,"ENSG00000109320","H2QPY8,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1","XP_001168718.1,-","PF12796,Ankyrin repeats (3 copies);PF00531,eath domain;PF00554,Rel homology DNA-binding domain;PF16179,Rel homology dimerisation domain","IPR030503,Nuclear factor NF-kappa-B, p105 subunit;IPR011539,Rel homology domain (RHD), DNA-binding domain;IPR020683,Ankyrin repeat-containing domain;IPR008967,p53-like transcription factor, DNA-binding;IPR032397,Rel homology dimerisation domain;IPR011029,Death-like domain superfamily;IPR030492,Rel homology domain, conserved site;IPR037059,Rel homology domain (RHD), DNA-binding domain superfamily;IPR000488,Death domain;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set;IPR002909,IPT domain;IPR002110,Ankyrin repeat;IPR033926,NFkappaB IPT domain;IPR000451,NF-kappa-B/Dorsal;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","GO:0010956,biological_process,negative regulation of calcidiol 1-monooxygenase activity;GO:0001205,molecular_function,transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0034097,biological_process,response to cytokine;GO:0035994,biological_process,response to muscle stretch;GO:0038061,biological_process,NIK/NF-kappaB signaling;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0071260,biological_process,cellular response to mechanical stimulus;GO:0008134,molecular_function,transcription factor binding;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0046982,molecular_function,protein heterodimerization activity;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0071347,biological_process,cellular response to interleukin-1;GO:0007249,biological_process,I-kappaB kinase/NF-kappaB signaling;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0001818,biological_process,negative regulation of cytokine production;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000980,molecular_function,RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0010629,biological_process,negative regulation of gene expression;GO:0006954,biological_process,inflammatory response;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0005829,cellular_component,cytosol;GO:0033256,cellular_component,I-kappaB/NF-kappaB complex;GO:1904385,biological_process,cellular response to angiotensin;GO:0050728,biological_process,negative regulation of inflammatory response;GO:0003682,molecular_function,chromatin binding;GO:0005739,cellular_component,mitochondrion;GO:0071316,biological_process,cellular response to nicotine;GO:2000630,biological_process,positive regulation of miRNA metabolic process;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0071359,biological_process,cellular response to dsRNA;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:1900127,biological_process,positive regulation of hyaluronan biosynthetic process;GO:0042802,molecular_function,identical protein binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0007165,biological_process,signal transduction;GO:0071354,biological_process,cellular response to interleukin-6;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0045087,biological_process,innate immune response;GO:0045083,biological_process,negative regulation of interleukin-12 biosynthetic process;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0005654,cellular_component,nucleoplasm;GO:0042805,molecular_function,actinin binding;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway","K02580,ko05140,Leishmaniasis;K02580,ko05030,Cocaine addiction;K02580,ko04211,Longevity regulating pathway;K02580,ko05161,Hepatitis B;K02580,ko04662,B cell receptor signaling pathway;K02580,ko05321,Inflammatory bowel disease (IBD);K02580,ko04210,Apoptosis;K02580,ko05160,Hepatitis C;K02580,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K02580,ko04062,Chemokine signaling pathway;K02580,ko04722,Neurotrophin signaling pathway;K02580,ko05212,Pancreatic cancer;K02580,ko05168,Herpes simplex infection;K02580,ko04931,Insulin resistance;K02580,ko05222,Small cell lung cancer;K02580,ko04151,PI3K-Akt signaling pathway;K02580,ko05220,Chronic myeloid leukemia;K02580,ko04066,HIF-1 signaling pathway;K02580,ko05202,Transcriptional misregulation in cancer;K02580,ko05134,Legionellosis;K02580,ko05215,Prostate cancer;K02580,ko05152,Tuberculosis;K02580,ko04933,AGE-RAGE signaling pathway in diabetic complications;K02580,ko04932,Non-alcoholic fatty liver disease (NAFLD);K02580,ko05164,Influenza A;K02580,ko05133,Pertussis;K02580,ko04917,Prolactin signaling pathway;K02580,ko04024,cAMP signaling pathway;K02580,ko05131,Shigellosis;K02580,ko05200,Pathways in cancer;K02580,ko05169,Epstein-Barr virus infection;K02580,ko04622,RIG-I-like receptor signaling pathway;K02580,ko04668,TNF signaling pathway;K02580,ko04620,Toll-like receptor signaling pathway;K02580,ko05221,Acute myeloid leukemia;K02580,ko05132,Salmonella infection;K02580,ko05145,Toxoplasmosis;K02580,ko04920,Adipocytokine signaling pathway;K02580,ko05142,Chagas disease (American trypanosomiasis);K02580,ko05203,Viral carcinogenesis;K02580,ko04071,Sphingolipid signaling pathway;K02580,ko05162,Measles;K02580,ko04380,Osteoclast differentiation;K02580,ko04010,MAPK signaling pathway;K02580,ko04660,T cell receptor signaling pathway;K02580,ko04623,Cytosolic DNA-sensing pathway;K02580,ko04014,Ras signaling pathway;K02580,ko05206,MicroRNAs in cancer;K02580,ko05166,HTLV-I infection;K02580,ko05146,Amoebiasis;K02580,ko04064,NF-kappa B signaling pathway;K02580,ko04621,NOD-like receptor signaling pathway"]
["GMFB",6.081078287,2.303433709,1.398862075,5.099549359,{"v":2.16e-06,"d":"2.16E-06"},{"v":9.51e-06,"d":"9.51E-06"},"ENSG00000197045","G3V4P8,Glia maturation factor beta","-","PF00241,Cofilin/tropomyosin-type actin-binding protein","IPR002108,Actin-depolymerising factor homology domain;IPR011171,Glia maturation factor;IPR029006,ADF-H/Gelsolin-like domain superfamily","ENOG4111RK6,-;KOG1736,Glia maturation factor beta","GO:0034316,biological_process,negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0071933,molecular_function,Arp2/3 complex binding;GO:0003779,molecular_function,actin binding;GO:0005622,cellular_component,intracellular","-"]
["ZNF227",3.419725904,1.292812961,1.398671197,3.673416983,8.00376E-4,0.001973713,"ENSG00000131115","H2QGJ4,Zinc finger protein 227","XP_016791617.1,-;XP_016791622.1,-;XP_009434077.2,zinc finger protein 227 isoform X1;XP_016791621.1,-;XP_016791615.1,-;XP_016791616.1,-;XP_016791619.1,-;XP_016791618.1,-;XP_016791620.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["RALGAPB",5.676637685,2.152779699,1.397703488,5.654310157,{"v":2.46e-07,"d":"2.46E-07"},{"v":1.32e-06,"d":"1.32E-06"},"ENSG00000170471","K7CD71,Ral GTPase activating protein, beta subunit","XP_514640.4,-","-","IPR035974,Rap/Ran-GAP superfamily;IPR000331,Rap GTPase activating protein domain","ENOG411027C,-;KOG3652,Uncharacterized conserved protein","GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity","-"]
["FAM35A",11.81143108,4.480075392,1.396969012,5.147561837,{"v":1.88E-6,"d":"1.88E-06"},{"v":8.39e-06,"d":"8.39E-06"},"ENSG00000122376","H2NC60,Protein FAM35A","XP_009234308.1,-;XP_009234307.1,-;XP_009234306.1,-;XP_009234309.1,-;XP_009234304.1,protein FAM35A isoform X1","PF15793,Protein family FAM35, C-terminal","IPR031589,Protein FAM35A, C-terminal domain;IPR029715,Protein FAM35A","ENOG410IJB7,-;ENOG4111M58,-","-","-"]
["TPM3P9",13.90605645,5.274034904,1.396735829,4.852139307,{"v":6.49e-06,"d":"6.49E-06"},{"v":2.57e-05,"d":"2.57E-05"},"ENSG00000241015","Q6ZNT3,cDNA FLJ27206 fis, clone SYN03441","-","-","-","-","-","-"]
["SNX5",20.72140586,7.869196279,1.396341737,6.840770559,{"v":3.66e-09,"d":"3.66E-09"},{"v":2.98e-08,"d":"2.98E-08"},"ENSG00000089006","H2P136,Sorting nexin","XP_002830028.1,-;XP_009231607.1,-;XP_009231606.1,-","PF09325,Vps5 C terminal like;PF00787,PX domain","IPR015404,Sorting nexin Vps5-like, C-terminal;IPR014637,Sorting nexin-5/6/32;IPR036871,PX domain superfamily;IPR027267,AH/BAR domain superfamily;IPR028654,Sorting nexin-5;IPR001683,Phox homologous domain","ENOG410XPZY,-;KOG1660,Sorting nexin SNX6/TFAF2, contains PX domain","GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0015031,biological_process,protein transport;GO:0030904,cellular_component,retromer complex;GO:0031313,cellular_component,extrinsic component of endosome membrane;GO:0070685,cellular_component,macropinocytic cup;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0045296,molecular_function,cadherin binding;GO:0097422,cellular_component,tubular endosome;GO:0005829,cellular_component,cytosol;GO:0031234,cellular_component,extrinsic component of cytoplasmic side of plasma membrane;GO:0006886,biological_process,intracellular protein transport;GO:0031901,cellular_component,early endosome membrane;GO:0006907,biological_process,pinocytosis;GO:0034452,molecular_function,dynactin binding","K17920,ko04144,Endocytosis"]
["DCP2",5.202121563,1.975661411,1.395199689,5.194024678,{"v":1.41e-06,"d":"1.41E-06"},{"v":6.5e-06,"d":"6.50E-06"},"ENSG00000172795","H2QRB9,DCP2 decapping enzyme homolog","XP_016803526.1,-;XP_016809120.1,-","PF05026,cp2, box A domain;PF00293,NUDIX domain","IPR015797,NUDIX hydrolase-like domain superfamily;IPR036189,mRNA decapping protein 2, Box A domain superfamily;IPR000086,NUDIX hydrolase domain;IPR007722,mRNA decapping protein 2, Box A domain;IPR020084,NUDIX hydrolase, conserved site","KOG2937,Decapping enzyme complex, predicted pyrophosphatase DCP2;COG0494,NTP pyrophosphohydrolases including oxidative damage repair enzymes","GO:0030054,cellular_component,cell junction;GO:0090503,biological_process,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0016787,molecular_function,hydrolase activity;GO:0000290,biological_process,deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:1904872,biological_process,regulation of telomerase RNA localization to Cajal body;GO:0016442,cellular_component,RISC complex;GO:0006402,biological_process,mRNA catabolic process;GO:0032211,biological_process,negative regulation of telomere maintenance via telomerase;GO:0003723,molecular_function,RNA binding;GO:0004534,molecular_function,5'-3' exoribonuclease activity;GO:0071044,biological_process,histone mRNA catabolic process;GO:0000932,cellular_component,P-body;GO:0050072,molecular_function,m7G(5')pppN diphosphatase activity;GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0030145,molecular_function,manganese ion binding;GO:0005654,cellular_component,nucleoplasm","K12613,ko03018,RNA degradation"]
["IQGAP1",31.51725032,11.9873406,1.394407545,7.97646526,{"v":3.3E-10,"d":"3.30E-10"},{"v":3.39e-09,"d":"3.39E-09"},"ENSG00000140575","A0A024RC65,HCG1991735, isoform CRA_a","NP_003861.1,ras GTPase-activating-like protein IQGAP1","PF00616,TPase-activator protein for Ras-like GTPase;PF03836,RasGAP C-terminus;PF00307,Calponin homology (CH) domain;PF00612,IQ calmodulin-binding motif","IPR001715,Calponin homology domain;IPR001202,WW domain;IPR036872,CH domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001936,Ras GTPase-activating domain;IPR000048,IQ motif, EF-hand binding site;IPR008936,Rho GTPase activation protein;IPR023152,Ras GTPase-activating protein, conserved site;IPR000593,RasGAP protein, C-terminal","COG5261,Protein involved in regulation of cellular morphogenesis/cytokinesis;KOG2128,Ras GTPase-activating protein family - IQGAP","GO:0044344,biological_process,cellular response to fibroblast growth factor stimulus;GO:1900006,biological_process,positive regulation of dendrite development;GO:1904754,biological_process,positive regulation of vascular associated smooth muscle cell migration;GO:0008543,biological_process,fibroblast growth factor receptor signaling pathway;GO:0048365,molecular_function,Rac GTPase binding;GO:0051019,molecular_function,mitogen-activated protein kinase binding;GO:0005634,cellular_component,nucleus;GO:0043005,cellular_component,neuron projection;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0005737,cellular_component,cytoplasm;GO:1900086,biological_process,positive regulation of peptidyl-tyrosine autophosphorylation;GO:1903829,biological_process,positive regulation of cellular protein localization;GO:0048008,biological_process,platelet-derived growth factor receptor signaling pathway;GO:0043087,biological_process,regulation of GTPase activity;GO:0043406,biological_process,positive regulation of MAP kinase activity;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:1990776,biological_process,response to angiotensin;GO:0030424,cellular_component,axon;GO:0015629,cellular_component,actin cytoskeleton;GO:0016328,cellular_component,lateral plasma membrane;GO:0045860,biological_process,positive regulation of protein kinase activity;GO:0016020,cellular_component,membrane;GO:0036120,biological_process,cellular response to platelet-derived growth factor stimulus;GO:0017048,molecular_function,Rho GTPase binding;GO:0007165,biological_process,signal transduction;GO:0045121,cellular_component,membrane raft;GO:0005911,cellular_component,cell-cell junction;GO:0005925,cellular_component,focal adhesion;GO:0030426,cellular_component,growth cone;GO:0051894,biological_process,positive regulation of focal adhesion assembly;GO:0031252,cellular_component,cell leading edge;GO:0035305,biological_process,negative regulation of dephosphorylation;GO:0001817,biological_process,regulation of cytokine production;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0030529,,","K16848,ko05205,Proteoglycans in cancer;K16848,ko04810,Regulation of actin cytoskeleton;K16848,ko04520,Adherens junction"]
["MPP7",0.847109323,0.318790444,1.394374026,2.102166429,0.039703125,0.064286385,"ENSG00000150054","B3KQ45,cDNA FLJ32798 fis, clone TESTI2002498, highly similar to Homo sapiens membrane protein, palmitoylated 7","-","PF07653,Variant SH3 domain;PF02828,L27 domain;PF00625,uanylate kinase;PF00595,PDZ domain (Also known as DHR or GLGF)","IPR014775,L27 domain, C-terminal;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036892,L27 domain superfamily;IPR035599,MPP7, SH3 domain;IPR036028,SH3-like domain superfamily;IPR020590,Guanylate kinase, conserved site;IPR008144,Guanylate kinase-like domain;IPR008145,Guanylate kinase/L-type calcium channel beta subunit;IPR001452,SH3 domain;IPR004172,L27 domain","COG0194,Guanylate kinase;KOG0609,Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase","-","-"]
["TXNL4B",1.64798839,0.620183177,1.394374026,2.102166429,0.039703125,0.064286385,"ENSG00000140830","H2QBH7,Thioredoxin-like 4B","XP_016785630.1,-;XP_511098.2,-;XP_003315248.1,-","PF02966,Mitosis protein DIM1","IPR004123,Dim1 family;IPR036249,Thioredoxin-like superfamily","ENOG4111FE6,-;KOG3414,Component of the U4/U6.U5 snRNP/mitosis protein DIM1","GO:0005682,cellular_component,U5 snRNP;GO:0005681,cellular_component,spliceosomal complex;GO:0005829,cellular_component,cytosol;GO:0000245,biological_process,spliceosomal complex assembly;GO:0046540,cellular_component,U4/U6 x U5 tri-snRNP complex;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0005654,cellular_component,nucleoplasm","-"]
["ZNF446",1.061166605,0.399346063,1.394374026,2.102166429,0.039703125,0.064286385,"ENSG00000083838","A0A087WUM8,Zinc finger protein 446","-","PF01352,KRAB box;PF02023,SCAN domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR003309,SCAN domain;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR038269,SCAN domain superfamily;IPR027764,Zinc finger protein 18/446","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0005515,molecular_function,protein binding;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","-"]
["HEMK1",0.268938131,0.101208786,1.394374026,2.102166429,0.039703125,0.064286385,"ENSG00000114735","A0A140VK98,HemK methyltransferase family member 1, isoform CRA_a","NP_001304780.1,-;NP_057257.1,hemK methyltransferase family member 1","PF13649,Methyltransferase domain;PF03602,Conserved hypothetical protein 95;PF05175,Methyltransferase small domain;PF13847,Methyltransferase domain;PF06325,Ribosomal protein L11 methyltransferase (PrmA);PF08241,Methyltransferase domain","IPR002295,N6 adenine-specific DNA methyltransferase, D21 class;IPR019874,Protein-(glutamine-N5) methyltransferase, release factor-specific;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR002052,DNA methylase, N-6 adenine-specific, conserved site;IPR004556,Modification methylase HemK;IPR007848,Methyltransferase small domain","-","GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0016740,molecular_function,transferase activity;GO:0008276,molecular_function,protein methyltransferase activity;GO:0006306,biological_process,DNA methylation;GO:0006479,biological_process,protein methylation;GO:0008170,molecular_function,N-methyltransferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0005739,cellular_component,mitochondrion","-"]
["MYH10",18.26211083,6.945257797,1.394261861,6.839268978,{"v":3.9e-09,"d":"3.90E-09"},{"v":3.15e-08,"d":"3.15E-08"},"ENSG00000133026","G7PTL5,Uncharacterized protein","-","PF02736,Myosin N-terminal SH3-like domain;PF01576,Myosin tail;PF00063,Myosin head (motor domain);PF00612,IQ calmodulin-binding motif","IPR004009,Myosin, N-terminal, SH3-like;IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR002928,Myosin tail;IPR000048,IQ motif, EF-hand binding site;IPR008989,Myosin S1 fragment, N-terminal;IPR027401,Myosin IQ motif-containing domain superfamily","-","GO:0001725,cellular_component,stress fiber;GO:0005844,cellular_component,polysome;GO:0016459,cellular_component,myosin complex;GO:0016887,molecular_function,ATPase activity;GO:0000146,molecular_function,microfilament motor activity;GO:0005524,molecular_function,ATP binding;GO:0016460,cellular_component,myosin II complex;GO:0005737,cellular_component,cytoplasm;GO:0005938,cellular_component,cell cortex;GO:0030048,biological_process,actin filament-based movement;GO:0031032,biological_process,actomyosin structure organization;GO:0005829,cellular_component,cytosol;GO:0051015,molecular_function,actin filament binding;GO:0003774,molecular_function,motor activity;GO:0030496,cellular_component,midbody;GO:0030898,molecular_function,actin-dependent ATPase activity;GO:0050714,biological_process,positive regulation of protein secretion;GO:0032154,cellular_component,cleavage furrow;GO:0003779,molecular_function,actin binding;GO:0042641,cellular_component,actomyosin;GO:0048027,molecular_function,mRNA 5'-UTR binding;GO:0000166,molecular_function,nucleotide binding;GO:0035613,molecular_function,RNA stem-loop binding;GO:0043531,molecular_function,ADP binding;GO:0000281,biological_process,mitotic cytokinesis;GO:0097513,cellular_component,myosin II filament","-"]
["IL10RB",4.17695946,1.585003472,1.393706461,3.799605651,0.000442871,1.156813E-3,"ENSG00000243646","K7AI61,Interleukin 10 receptor, beta","XP_016802672.1,-;XP_531433.2,interleukin-10 receptor subunit beta isoform X2","PF01108,Tissue factor;PF09294,Interferon-alpha/beta receptor, fibronectin type III","IPR003961,Fibronectin type III;IPR015373,Interferon/interleukin receptor domain;IPR013783,Immunoglobulin-like fold;IPR036116,Fibronectin type III superfamily","ENOG410IER7,-;ENOG410YTBJ,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SAYSD1",6.494636452,2.464477194,1.393706461,3.799605651,0.000442871,1.156813E-3,"ENSG00000112167","A0A024RCY7,Chromosome 6 open reading frame 64, isoform CRA_a","-","PF10260,Uncharacterized conserved domain (SAYSvFN)","IPR019387,Uncharacterised domain SAYSvFN","ENOG41127HA,-;KOG3249,Uncharacterized conserved protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SMG6",3.757423182,1.428133265,1.393573829,4.819770623,{"v":7.72e-06,"d":"7.72E-06"},{"v":3.01E-5,"d":"3.01E-05"},"ENSG00000070366","K7DHL1,Smg-6 homolog, nonsense mediated mRNA decay factor","-","PF10374,Telomerase activating protein Est1;PF13638,PIN domain;PF10373,st1 DNA/RNA binding domain","IPR018834,DNA/RNA-binding domain, Est1-type;IPR002716,PIN domain;IPR019458,Telomerase activating protein Est1;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR029060,PIN-like domain superfamily","ENOG410XR9Z,-;KOG2162,Nonsense-mediated mRNA decay protein","-","-"]
["PPP2R1A",10.88798031,4.14150381,1.393511516,5.827822753,{"v":1.24E-7,"d":"1.24E-07"},{"v":7.14e-07,"d":"7.14E-07"},"ENSG00000105568","A0A1U7R3I2,serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform","XP_005086759.1,-","-","IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR000357,HEAT repeat;IPR031090,Serine/threonine-protein phosphatase 2A subunit A, metazoa;IPR021133,HEAT, type 2","-","GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0019888,molecular_function,protein phosphatase regulator activity","-"]
["SORBS3",11.29464362,4.299339939,1.39227943,5.598261656,{"v":2.93e-07,"d":"2.93E-07"},{"v":1.55E-6,"d":"1.55E-06"},"ENSG00000120896","K7CKV0,Sorbin and SH3 domain containing 3","-","PF14604,Variant SH3 domain;PF00018,SH3 domain;PF02208,Sorbin homologous domain","-","-","-","-"]
["MBTD1",7.65043101,2.91215949,1.391986705,5.282680821,{"v":1.11E-6,"d":"1.11E-06"},{"v":5.19e-06,"d":"5.19E-06"},"ENSG00000011258","K7CZ08,Mbt domain containing 1","-","PF02820,mbt repeat","IPR038603,FCS-type zinc finger superfamily;IPR012313,Zinc finger, FCS-type;IPR004092,Mbt repeat","ENOG410Y4AQ,-;KOG3766,Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans)","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["PAK4",13.78370204,5.249983519,1.391756089,6.100801889,{"v":4.27e-08,"d":"4.27E-08"},{"v":2.73e-07,"d":"2.73E-07"},"ENSG00000130669","A0A024R0J1,p21","NP_001014831.1,-;XP_011524620.1,-;XP_011524619.1,-;NP_005875.1,serine/threonine-protein kinase PAK 4 isoform 1;XP_011524621.1,-;NP_001014832.1,-;XP_011524618.1,-","PF00069,Protein kinase domain;PF00786,P21-Rho-binding domain","IPR000095,CRIB domain;IPR036936,CRIB domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR033923,p21 activated kinase binding domain;IPR017441,Protein kinase, ATP binding site;IPR000719,Protein kinase domain","ENOG410XP4K,-;KOG0578,p21-activated serine/threonine protein kinase","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0060996,biological_process,dendritic spine development","K05734,ko05211,Renal cell carcinoma;K05734,ko04014,Ras signaling pathway;K05734,ko04360,Axon guidance;K05734,ko04012,ErbB signaling pathway;K05734,ko05206,MicroRNAs in cancer;K05734,ko04510,Focal adhesion;K05734,ko04660,T cell receptor signaling pathway;K05734,ko04810,Regulation of actin cytoskeleton"]
["CELSR2",1.326807841,0.504138429,1.391140723,3.598580638,0.000693457,0.001736393,"ENSG00000143126","H2N6I9,Cadherin EGF LAG seven-pass G-type receptor 2","-","PF16489,PCR-Autoproteolysis INducing (GAIN) domain;PF00053,Laminin EGF domain;PF00002,7 transmembrane receptor (Secretin family);PF00008,-like domain;PF02210,Laminin G domain;PF01825,PCR proteolysis site, GPS, motif;PF12661,Human growth factor-like EGF;PF00028,Cadherin domain","IPR001879,GPCR, family 2, extracellular hormone receptor domain;IPR002126,Cadherin;IPR015919,Cadherin-like;IPR036445,GPCR family 2, extracellular hormone receptor domain superfamily;IPR032471,GAIN domain, N-terminal;IPR000832,GPCR, family 2, secretin-like;IPR000203,GPS motif;IPR017981,GPCR, family 2-like;IPR001791,Laminin G domain;IPR001881,EGF-like calcium-binding domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR002049,Laminin EGF domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR020894,Cadherin conserved site","ENOG410XTGH,-;KOG4289,Cadherin EGF LAG seven-pass G-type receptor","GO:0016021,cellular_component,integral component of membrane;GO:0007155,biological_process,cell adhesion;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0005509,molecular_function,calcium ion binding;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0007165,biological_process,signal transduction","-"]
["CMTR1",6.528578132,2.48512283,1.391109322,4.622776533,{"v":1.97e-05,"d":"1.97E-05"},{"v":7.04e-05,"d":"7.04E-05"},"ENSG00000137200","G3QSA2,Cap methyltransferase 1","XP_004043993.1,-","PF01728,tsJ-like methyltransferase;PF01585,-patch domain","IPR001202,WW domain;IPR000467,G-patch domain;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR002877,Ribosomal RNA methyltransferase FtsJ domain;IPR030376,Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1;IPR025816,RrmJ-type ribose 2-O-methyltransferase domain","-","GO:0004483,molecular_function,mRNA (nucleoside-2'-O-)-methyltransferase activity;GO:0006370,biological_process,7-methylguanosine mRNA capping;GO:0003676,molecular_function,nucleic acid binding;GO:0080009,biological_process,mRNA methylation;GO:0097309,biological_process,cap1 mRNA methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["DNAJB12",16.43599165,6.264409996,1.39074012,6.023134714,{"v":6e-08,"d":"6.00E-08"},{"v":3.71e-07,"d":"3.71E-07"},"ENSG00000148719","J3KPS0,DnaJ","XP_005269989.1,-;NP_060096.3,-;NP_001002762.2,dnaJ homolog subfamily B member 12","PF00226,naJ domain;PF09320,omain of unknown function (DUF1977)","IPR018253,DnaJ domain, conserved site;IPR036869,Chaperone J-domain superfamily;IPR015399,Domain of unknown function DUF1977, DnaJ-like;IPR001623,DnaJ domain","COG0484,DnaJ-class molecular chaperone with C-terminal Zn finger domain;KOG0714,Molecular chaperone (DnaJ superfamily)","-","K09518,ko04141,Protein processing in endoplasmic reticulum"]
["PREPL",3.3785572,1.286057923,1.390525062,4.312340374,{"v":6.19E-5,"d":"6.19E-05"},0.000196953,"ENSG00000138078","H2QHU5,Prolyl endopeptidase-like","-","PF02897,Prolyl oligopeptidase, N-terminal beta-propeller domain;PF00326,Prolyl oligopeptidase family","IPR002470,Peptidase S9A, prolyl oligopeptidase;IPR001375,Peptidase S9, prolyl oligopeptidase, catalytic domain;IPR029058,Alpha/Beta hydrolase fold;IPR023302,Peptidase S9A, N-terminal domain","ENOG410IU1B,-;COG1770,Protease II","GO:0006508,biological_process,proteolysis;GO:0005794,cellular_component,Golgi apparatus;GO:0070008,molecular_function,serine-type exopeptidase activity;GO:0005856,cellular_component,cytoskeleton;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0008236,molecular_function,serine-type peptidase activity","-"]
["TCOF1",20.94988868,7.98966549,1.390394735,7.35868614,{"v":1.2E-9,"d":"1.20E-09"},{"v":1.08e-08,"d":"1.08E-08"},"ENSG00000070814","J3KQ96,Treacle protein","-","PF03546,Treacher Collins syndrome protein Treacle","IPR003993,Treacher Collins syndrome, treacle;IPR017859,Treacle-like, Treacher Collins Syndrome;IPR006594,LIS1 homology motif","ENOG410IF55,-;ENOG411183W,-","GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0001650,cellular_component,fibrillar center","-"]
["PPP1R37",4.947718737,1.884808261,1.390264208,4.786654904,{"v":1.09e-05,"d":"1.09E-05"},{"v":4.13e-05,"d":"4.13E-05"},"ENSG00000104866","A0A0D9S1T5,Protein phosphatase 1 regulatory subunit 37","XP_007995364.1,protein phosphatase 1 regulatory subunit 37 isoform X2","PF13516,Leucine Rich repeat","IPR001611,Leucine-rich repeat;IPR032675,Leucine-rich repeat domain superfamily","-","GO:0010923,biological_process,negative regulation of phosphatase activity","-"]
["AL513523.2",17.41908317,6.630626207,1.389552467,3.915560058,0.0002523,0.000699636,"ENSG00000279767","Q9H3A6,PRO2179","-","-","-","-","-","-"]
["ANAPC4",1.267468083,0.480957819,1.389473643,2.869321197,0.009315432,0.017883006,"ENSG00000053900","H2QPA9,Anaphase promoting complex subunit 4","XP_009445720.1,-","PF12894,Anaphase-promoting complex subunit 4 WD40 domain;PF12896,Anaphase-promoting complex, cyclosome, subunit 4","IPR024790,Anaphase-promoting complex subunit 4 long domain;IPR017169,Anaphase-promoting complex subunit 4, metazoa;IPR024977,Anaphase-promoting complex subunit 4, WD40 domain;IPR036322,WD40-repeat-containing domain superfamily;IPR024789,Anaphase-promoting complex subunit 4;IPR015943,WD40/YVTN repeat-like-containing domain superfamily","KOG4640,Anaphase-promoting complex (APC), subunit 4;ENOG410XPXK,-","GO:0031145,biological_process,anaphase-promoting complex-dependent catabolic process;GO:0070979,biological_process,protein K11-linked ubiquitination;GO:0030071,biological_process,regulation of mitotic metaphase/anaphase transition;GO:0019903,molecular_function,protein phosphatase binding;GO:0005680,cellular_component,anaphase-promoting complex;GO:0005634,cellular_component,nucleus","K03351,ko05166,HTLV-I infection;K03351,ko04110,Cell cycle;K03351,ko04114,Oocyte meiosis;K03351,ko04113,Meiosis - yeast;K03351,ko04111,Cell cycle - yeast;K03351,ko04120,Ubiquitin mediated proteolysis;K03351,ko04914,Progesterone-mediated oocyte maturation"]
["IPO4",10.2913624,3.926464291,1.388571015,5.189275993,{"v":1.41e-06,"d":"1.41E-06"},{"v":6.5e-06,"d":"6.50E-06"},"ENSG00000196497","B3KQ33,cDNA FLJ32715 fis, clone TESTI2000784, highly similar to Importin-4","-","PF02985,HEAT repeat;PF03810,Importin-beta N-terminal domain","IPR016024,Armadillo-type fold;IPR000357,HEAT repeat;IPR001494,Importin-beta, N-terminal domain;IPR021133,HEAT, type 2;IPR034085,TOG domain","ENOG410IQKY,-;ENOG410XP2Z,-","GO:0008536,molecular_function,Ran GTPase binding;GO:0005622,cellular_component,intracellular;GO:0006886,biological_process,intracellular protein transport","-"]
["B3GNT2",8.714895231,3.321300212,1.388508958,4.174883859,{"v":8.43e-05,"d":"8.43E-05"},0.000258747,"ENSG00000170340","H2QHZ0,Hexosyltransferase","XP_001152203.2,-","PF01762,alactosyltransferase","IPR002659,Glycosyl transferase, family 31","ENOG410ZZ1B,-;KOG2287,Galactosyltransferases","GO:0005794,cellular_component,Golgi apparatus;GO:0008378,molecular_function,galactosyltransferase activity;GO:0008532,molecular_function,N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0030311,biological_process,poly-N-acetyllactosamine biosynthetic process;GO:0007411,biological_process,axon guidance;GO:0006486,biological_process,protein glycosylation;GO:0016740,molecular_function,transferase activity;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0007608,biological_process,sensory perception of smell;GO:0000139,cellular_component,Golgi membrane;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K00741,ko00533,Glycosaminoglycan biosynthesis - keratan sulfate;K00741,ko00601,Glycosphingolipid biosynthesis - lacto and neolacto series"]
["CTD-2292M16.7",18.41268506,7.008843745,1.387611663,3.364510503,0.002390599,0.005331473,"-","-","-","-","-","-","-","-"]
["HERC1",3.773629237,1.44108124,1.387553195,5.503525379,{"v":4.42e-07,"d":"4.42E-07"},{"v":2.25e-06,"d":"2.25E-06"},"ENSG00000103657","A0A024R5W0,Hect","NP_003913.3,probable E3 ubiquitin-protein ligase HERC1","PF00632,HECT-domain (ubiquitin-transferase);PF00415,Regulator of chromosome condensation (RCC1) repeat;PF00400,WD domain, G-beta repeat;PF00622,SPRY domain","IPR019775,WD40 repeat, conserved site;IPR035983,HECT, E3 ligase catalytic domain;IPR035768,HERC1, SPRY domain;IPR001870,B30.2/SPRY domain;IPR000569,HECT domain;IPR009091,Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II;IPR036322,WD40-repeat-containing domain superfamily;IPR000408,Regulator of chromosome condensation, RCC1;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR001680,WD40 repeat;IPR003877,SPRY domain;IPR017986,WD40-repeat-containing domain","KOG1426,FOG: RCC1 domain;COG5021,Ubiquitin-protein ligase;COG5184,Alpha-tubulin suppressor and related RCC1 domain-containing proteins","GO:0031175,biological_process,neuron projection development;GO:0016567,biological_process,protein ubiquitination;GO:0016740,molecular_function,transferase activity;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0021702,biological_process,cerebellar Purkinje cell differentiation;GO:0050885,biological_process,neuromuscular process controlling balance;GO:0010507,biological_process,negative regulation of autophagy","K10594,ko04120,Ubiquitin mediated proteolysis"]
["KIAA0907",5.94177116,2.267768298,1.387221442,4.584723598,{"v":1.67e-05,"d":"1.67E-05"},{"v":6.07e-05,"d":"6.07E-05"},"ENSG00000132680","G7NV70,Uncharacterized protein","XP_005541554.1,-","-","IPR031121,KH domain containing protein RIK/BLOM7;IPR036612,K Homology domain, type 1 superfamily","-","GO:0005737,cellular_component,cytoplasm;GO:0003723,molecular_function,RNA binding;GO:0005681,cellular_component,spliceosomal complex;GO:0005634,cellular_component,nucleus;GO:0006376,biological_process,mRNA splice site selection","-"]
["ESPL1",2.030030488,0.774008138,1.386630961,3.731256243,0.000593123,1.50768E-3,"ENSG00000135476","K7C9C2,Extra spindle pole bodies homolog 1","-","PF03568,Peptidase family C50","-","-","-","-"]
["CTNNAL1",23.814272,9.104669346,1.386072829,5.712673544,{"v":2.08e-07,"d":"2.08E-07"},{"v":1.14e-06,"d":"1.14E-06"},"ENSG00000119326","B3KMX6,cDNA FLJ12864 fis, clone NT2RP2003604, highly similar to Alpha-catulin","NP_003789.1,alpha-catulin isoform a;NP_001273903.1,alpha-catulin isoform b","PF01044,Vinculin family","IPR006077,Vinculin/alpha-catenin;IPR001033,Alpha-catenin;IPR036723,Alpha-catenin/vinculin-like superfamily;IPR030045,Alpha-catulin 1","KOG3681,Alpha-catenin;ENOG410XSRU,-","GO:0051015,molecular_function,actin filament binding;GO:0045296,molecular_function,cadherin binding;GO:0007155,biological_process,cell adhesion;GO:0007266,biological_process,Rho protein signal transduction;GO:0005622,cellular_component,intracellular","-"]
["RP11-474G23.1",41.60186413,15.91426967,1.385492251,6.07110425,{"v":6.02e-08,"d":"6.02E-08"},{"v":3.72E-7,"d":"3.72E-07"},"ENSG00000273398","H7BYZ3,Uncharacterized protein","-","PF13499,-hand domain pair;PF13833,-hand domain pair","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR011992,EF-hand domain pair","KOG0034,Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein;COG5126,Ca2+-binding protein (EF-Hand superfamily)","GO:0005509,molecular_function,calcium ion binding","-"]
["NIP7",14.6508703,5.604506086,1.384658358,5.089381419,{"v":2.93e-06,"d":"2.93E-06"},{"v":1.25e-05,"d":"1.25E-05"},"ENSG00000132603","G3RX93,60S ribosome subunit biogenesis protein NIP7 homolog","XP_004057927.1,-","PF03657,Uncharacterised protein family (UPF0113)","IPR005155,Ribosome biogenesis factor NIP7-like;IPR036974,PUA domain superfamily;IPR015947,PUA-like superfamily;IPR002478,PUA domain;IPR016686,Ribosome biogenesis factor, NIP7","-","GO:0042254,biological_process,ribosome biogenesis;GO:0005730,cellular_component,nucleolus;GO:0042255,biological_process,ribosome assembly;GO:0003723,molecular_function,RNA binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["RP1-20B21.4",324.503414,124.3224647,1.383354845,6.143858174,{"v":4.74e-08,"d":"4.74E-08"},{"v":3e-07,"d":"3.00E-07"},"-","-","-","-","-","-","-","-"]
["SGK223",4.890594346,1.870835331,1.382993807,4.12260965,0.000134283,3.95864E-4,"ENSG00000275342","H2QZR5,PEAK1 related kinase activating pseudokinase 1","XP_009438503.2,-;XP_001136236.2,tyrosine-protein kinase SgK223;XP_016814548.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR008266,Tyrosine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410IJMD,-;ENOG4110SRP,-","GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["TRIM21",10.21731055,3.906821792,1.382891262,3.852658928,3.33099E-4,0.000896865,"ENSG00000132109","H2Q2Y1,Tripartite motif containing 21","XP_508239.2,-","PF00643,B-box zinc finger;PF00097,Zinc finger, C3HC4 type (RING finger);PF13765,SPRY-associated domain;PF00622,SPRY domain","IPR003613,U box domain;IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR035831,TRIM21, PRY/SPRY domain;IPR003877,SPRY domain;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR020457,Zinc finger, B-box, chordata;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000315,B-box-type zinc finger;IPR006574,SPRY-associated","ENOG410ITFV,-;ENOG410YDPJ,-","GO:0000209,biological_process,protein polyubiquitination;GO:0090086,biological_process,negative regulation of protein deubiquitination;GO:0019005,cellular_component,SCF ubiquitin ligase complex;GO:0005634,cellular_component,nucleus;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0070206,biological_process,protein trimerization;GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0045787,biological_process,positive regulation of cell cycle;GO:0042802,molecular_function,identical protein binding;GO:0010508,biological_process,positive regulation of autophagy;GO:0051091,biological_process,positive regulation of DNA binding transcription factor activity;GO:1902187,biological_process,negative regulation of viral release from host cell;GO:0046598,biological_process,positive regulation of viral entry into host cell;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0051865,biological_process,protein autoubiquitination;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm;GO:0032897,biological_process,negative regulation of viral transcription;GO:0045087,biological_process,innate immune response;GO:0034341,biological_process,response to interferon-gamma;GO:0046872,molecular_function,metal ion binding;GO:0031648,biological_process,protein destabilization;GO:0005622,cellular_component,intracellular;GO:0006513,biological_process,protein monoubiquitination","K10651,ko05322,Systemic lupus erythematosus"]
["KCNN4",5.9924573,2.291352763,1.382891262,3.852658928,3.33099E-4,0.000896865,"ENSG00000104783","K7BT53,Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4","XP_016791575.1,intermediate conductance calcium-activated potassium channel protein 4 isoform X1","PF07885,Ion channel;PF02888,Calmodulin binding domain;PF03530,Calcium-activated SK potassium channel","IPR015449,Potassium channel, calcium-activated, SK;IPR004178,Calmodulin-binding domain;IPR013099,Potassium channel domain;IPR036122,SK, calmodulin-binding domain superfamily","KOG3684,Ca2+-activated K+ channel proteins (intermediate/small conductance classes);ENOG410XT9D,-","GO:0046541,biological_process,saliva secretion;GO:0005267,molecular_function,potassium channel activity;GO:0030322,biological_process,stabilization of membrane potential;GO:0015269,molecular_function,calcium-activated potassium channel activity;GO:0045332,biological_process,phospholipid translocation;GO:0005516,molecular_function,calmodulin binding;GO:0006816,biological_process,calcium ion transport;GO:0019903,molecular_function,protein phosphatase binding;GO:0006884,biological_process,cell volume homeostasis;GO:0016286,molecular_function,small conductance calcium-activated potassium channel activity;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0050862,biological_process,positive regulation of T cell receptor signaling pathway;GO:0016020,cellular_component,membrane;GO:0006813,biological_process,potassium ion transport;GO:0031982,cellular_component,vesicle;GO:0050714,biological_process,positive regulation of protein secretion;GO:0016021,cellular_component,integral component of membrane","K04945,ko04974,Protein digestion and absorption;K04945,ko04911,Insulin secretion;K04945,ko04970,Salivary secretion"]
["PCSK7",0.692055304,0.264446129,1.382732065,3.519590955,0.001232418,0.002920528,"ENSG00000160613","H2R3M8,Proprotein convertase subtilisin/kexin type 7","-","PF00082,Subtilase family;PF16470,Peptidase S8 pro-domain;PF01483,Proprotein convertase P-domain","IPR000209,Peptidase S8/S53 domain;IPR032815,Peptidase S8, pro-domain;IPR023828,Peptidase S8, subtilisin, Ser-active site;IPR008979,Galactose-binding-like domain superfamily;IPR015500,Peptidase S8, subtilisin-related;IPR038466,Peptidase S8, pro-domain superfamily;IPR022398,Peptidase S8, subtilisin, His-active site;IPR002884,P domain;IPR036852,Peptidase S8/S53 domain superfamily;IPR034182,Kexin/furin catalytic domain","KOG3525,Subtilisin-like proprotein convertase;COG4935,Regulatory P domain of the subtilisin-like proprotein convertases and other proteases;COG1404,Subtilisin-like serine proteases","GO:0006508,biological_process,proteolysis;GO:0004252,molecular_function,serine-type endopeptidase activity","-"]
["TMEM189-UBE2V1",145.0427583,55.62078067,1.382582751,8.116644024,{"v":3.56e-10,"d":"3.56E-10"},{"v":3.63e-09,"d":"3.63E-09"},"ENSG00000124208","I3L0A0,HCG2044781","-","PF10520,B domain of TMEM189, localisation domain;PF00179,Ubiquitin-conjugating enzyme","IPR019547,B domain of TMEM189, localisation domain;IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR000608,Ubiquitin-conjugating enzyme E2","KOG0896,Ubiquitin-conjugating enzyme E2;ENOG410XRWR,-;KOG3011,Ubiquitin-conjugating enzyme","GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0006301,biological_process,postreplication repair;GO:0005737,cellular_component,cytoplasm;GO:0070534,biological_process,protein K63-linked ubiquitination;GO:0016020,cellular_component,membrane;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["MYH14",11.81906629,4.532043612,1.382200742,6.35581485,{"v":2.63e-08,"d":"2.63E-08"},{"v":1.77e-07,"d":"1.77E-07"},"ENSG00000105357","H2R5W8,Myosin heavy chain 14","XP_003316591.1,myosin-14 isoform X3","PF01576,Myosin tail;PF00063,Myosin head (motor domain);PF02736,Myosin N-terminal SH3-like domain","IPR002928,Myosin tail;IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004009,Myosin, N-terminal, SH3-like;IPR000048,IQ motif, EF-hand binding site;IPR036961,Kinesin motor domain superfamily;IPR008989,Myosin S1 fragment, N-terminal;IPR027401,Myosin IQ motif-containing domain superfamily","COG5022,Myosin heavy chain;KOG0161,Myosin class II heavy chain","GO:0003777,molecular_function,microtubule motor activity;GO:0016459,cellular_component,myosin complex;GO:0007018,biological_process,microtubule-based movement;GO:0003779,molecular_function,actin binding;GO:0008017,molecular_function,microtubule binding;GO:0051015,molecular_function,actin filament binding;GO:0003774,molecular_function,motor activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["USP12",10.69599114,4.099735116,1.382031288,5.297418985,{"v":1.12e-06,"d":"1.12E-06"},{"v":5.23e-06,"d":"5.23E-06"},"ENSG00000152484","H9FR75,Ubiquitin carboxyl-terminal hydrolase 12","-","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase","ENOG410XQ81,-;KOG1864,Ubiquitin-specific protease","GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016787,molecular_function,hydrolase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016579,biological_process,protein deubiquitination","-"]
["RAB4B",1.751804684,0.666829703,1.381824082,2.453490441,0.026994048,0.045636644,"ENSG00000167578","I3ND19,Uncharacterized protein","XP_005336504.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0086,GTPase Rab4, small G protein superfamily;ENOG410XQ9X,-","GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity","-"]
["VEZT",5.369088588,2.057952436,1.381770491,5.061984677,{"v":2.91e-06,"d":"2.91E-06"},{"v":1.24E-5,"d":"1.24E-05"},"ENSG00000028203","H2Q6M6,Vezatin, adherens junctions transmembrane protein","-","PF12632,Mysoin-binding motif of peroxisomes","IPR026858,Vezatin;IPR026859,Myosin-binding domain","ENOG410YQJU,-;ENOG410IHYP,-","GO:0098609,biological_process,cell-cell adhesion;GO:0017022,molecular_function,myosin binding","-"]
["GDF11",4.937371624,1.892476869,1.381601029,4.928041859,{"v":6.43e-06,"d":"6.43E-06"},{"v":2.55E-5,"d":"2.55E-05"},"ENSG00000135414","H2Q663,Uncharacterized protein","XP_016778746.1,-;XP_003313658.1,-","PF00019,Transforming growth factor beta like domain;PF00688,TGF-beta propeptide","IPR001839,Transforming growth factor-beta, C-terminal;IPR015615,Transforming growth factor-beta-related;IPR017948,Transforming growth factor beta, conserved site;IPR029034,Cystine-knot cytokine;IPR001111,TGF-beta, propeptide","ENOG410XT8Z,-;KOG3900,Transforming growth factor beta, bone morphogenetic protein and related proteins","GO:0008083,molecular_function,growth factor activity;GO:0048593,biological_process,camera-type eye morphogenesis;GO:0009887,biological_process,animal organ morphogenesis;GO:0005576,cellular_component,extracellular region;GO:0060395,biological_process,SMAD protein signal transduction;GO:0060021,biological_process,roof of mouth development;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0001657,biological_process,ureteric bud development;GO:0005615,cellular_component,extracellular space;GO:0010862,biological_process,positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0031016,biological_process,pancreas development;GO:0001656,biological_process,metanephros development;GO:0048468,biological_process,cell development;GO:0042981,biological_process,regulation of apoptotic process;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005654,cellular_component,nucleoplasm;GO:0048469,biological_process,cell maturation;GO:0021512,biological_process,spinal cord anterior/posterior patterning;GO:0005125,molecular_function,cytokine activity;GO:0001501,biological_process,skeletal system development;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0043408,biological_process,regulation of MAPK cascade;GO:0005160,molecular_function,transforming growth factor beta receptor binding;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0045596,biological_process,negative regulation of cell differentiation","-"]
["TBC1D15",3.636803003,1.393973572,1.380802739,4.429665268,{"v":4.65e-05,"d":"4.65E-05"},1.52227E-4,"ENSG00000121749","H2Q6H3,Uncharacterized protein","-","PF12068,omain of unknown function (DUF3548);PF00566,Rab-GTPase-TBC domain","-","-","-","-"]
["DDX11",4.792305296,1.83904728,1.379777211,4.840031279,{"v":7.69e-06,"d":"7.69E-06"},{"v":3e-05,"d":"3.00E-05"},"ENSG00000013573","H2R1L2,DEAD/H-box helicase 11","-","PF13307,Helicase C-terminal domain;PF06733,AD_2","IPR028331,Probable ATP-dependent RNA helicase DDX11/DDX12;IPR013020,ATP-dependent helicase Rad3/Chl1-like;IPR006554,Helicase-like, DEXD box c2 type;IPR014013,Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type;IPR010614,DEAD2;IPR006555,ATP-dependent helicase, C-terminal","COG1199,Rad3-related DNA helicases;KOG1133,Helicase of the DEAD superfamily","GO:0004386,molecular_function,helicase activity;GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005634,cellular_component,nucleus;GO:0016787,molecular_function,hydrolase activity;GO:0016818,molecular_function,hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0032508,biological_process,DNA duplex unwinding;GO:0004003,molecular_function,ATP-dependent DNA helicase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0008026,molecular_function,ATP-dependent helicase activity;GO:0006139,biological_process,nucleobase-containing compound metabolic process","-"]
["NOC4L",10.53297835,4.037252896,1.379739894,3.964562151,0.000293035,0.000800375,"ENSG00000184967","K7BST0,Nucleolar complex associated 4 homolog","-","PF03914,CBF/Mak21 family","IPR027193,Nucleolar complex protein 4;IPR016024,Armadillo-type fold;IPR005612,CCAAT-binding factor","-","GO:0042254,biological_process,ribosome biogenesis","-"]
["POLR3D",10.79171931,4.14616015,1.378763875,5.419739778,{"v":9.2e-07,"d":"9.20E-07"},{"v":4.38e-06,"d":"4.38E-06"},"ENSG00000168495","H2QVU9,Polymerase","XP_001155075.1,-","PF05132,RNA polymerase III RPC4","IPR007811,DNA-directed RNA polymerase III subunit RPC4","KOG3122,DNA-directed RNA polymerase III subunit;ENOG410XPDH,-","GO:0032728,biological_process,positive regulation of interferon-beta production;GO:0003677,molecular_function,DNA binding;GO:0045089,biological_process,positive regulation of innate immune response;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0001056,molecular_function,RNA polymerase III activity;GO:0016607,cellular_component,nuclear speck;GO:0005829,cellular_component,cytosol;GO:0000790,cellular_component,nuclear chromatin;GO:0005666,cellular_component,DNA-directed RNA polymerase III complex;GO:0005654,cellular_component,nucleoplasm;GO:0003682,molecular_function,chromatin binding;GO:0006383,biological_process,transcription by RNA polymerase III","K03026,ko03020,RNA polymerase;K03026,ko00240,Pyrimidine metabolism;K03026,ko00230,Purine metabolism;K03026,ko04623,Cytosolic DNA-sensing pathway;K03026,ko05169,Epstein-Barr virus infection"]
["SPAG9",16.59422231,6.381809137,1.378243484,7.112328056,{"v":3E-9,"d":"3.00E-09"},{"v":2.48E-8,"d":"2.48E-08"},"ENSG00000008294","H2R0E7,Sperm associated antigen 9","XP_003953191.1,C-Jun-amino-terminal kinase-interacting protein 4 isoform X14","PF09744,JNK_SAPK-associated protein-1;PF16471,JNK-interacting protein  leucine zipper II","IPR034744,RH2 domain;IPR032486,JNK-interacting protein, leucine zipper II;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR034743,RH1 domain;IPR019143,JNK/Rab-associated protein-1, N-terminal","ENOG410XQ19,-;KOG2077,JNK/SAPK-associated protein-1","GO:0007257,biological_process,activation of JUN kinase activity;GO:0019894,molecular_function,kinesin binding;GO:0030159,molecular_function,receptor signaling complex scaffold activity;GO:0005737,cellular_component,cytoplasm;GO:0008432,molecular_function,JUN kinase binding;GO:0005078,molecular_function,MAP-kinase scaffold activity;GO:0016192,biological_process,vesicle-mediated transport","-"]
["CDC123",31.90500288,12.2669343,1.377972283,5.75494814,{"v":2.22E-7,"d":"2.22E-07"},{"v":1.21e-06,"d":"1.21E-06"},"ENSG00000151465","H2Q1M2,Cell division cycle protein 123 homolog","-","PF07065,123","IPR009772,Cell division cycle protein 123","ENOG410XSVC,-;KOG2983,Uncharacterized conserved protein","GO:0005737,cellular_component,cytoplasm;GO:0006417,biological_process,regulation of translation;GO:0007049,biological_process,cell cycle;GO:0007050,biological_process,cell cycle arrest;GO:0051301,biological_process,cell division","-"]
["C6orf62",18.55336887,7.133456714,1.377972283,5.75494814,{"v":2.22E-7,"d":"2.22E-07"},{"v":1.21e-06,"d":"1.21E-06"},"ENSG00000112308","G7P4J9,HBV X-transactivated gene 12 protein","XP_005553959.1,-","PF15130,omain of unknown function (DUF4566)","IPR027903,Protein of unknown function DUF4566","-","GO:0005622,cellular_component,intracellular","-"]
["BCKDK",12.32364813,4.737710541,1.377503713,5.084269807,{"v":3.41E-6,"d":"3.41E-06"},{"v":1.44e-05,"d":"1.44E-05"},"ENSG00000103507","A0A024QZA9,Branched chain ketoacid dehydrogenase kinase, isoform CRA_b","NP_005872.2,","PF10436,Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase;PF02518,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase","IPR005467,Histidine kinase domain;IPR018955,Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal;IPR036784,Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily;IPR036890,Histidine kinase/HSP90-like ATPase superfamily;IPR004358,Signal transduction histidine kinase-related protein, C-terminal;IPR003594,Histidine kinase/HSP90-like ATPase","COG0642,Signal transduction histidine kinase;KOG0787,Dehydrogenase kinase","GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0047323,molecular_function,[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity;GO:0009083,biological_process,branched-chain amino acid catabolic process;GO:0016310,biological_process,phosphorylation;GO:0005739,cellular_component,mitochondrion;GO:0005947,cellular_component,mitochondrial alpha-ketoglutarate dehydrogenase complex;GO:0005524,molecular_function,ATP binding;GO:0016772,molecular_function,transferase activity, transferring phosphorus-containing groups;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["C15orf40",1.657930907,0.636789248,1.37704814,4.068350506,0.000173128,0.000497171,"ENSG00000169609","A0A1D5R8V3,Chromosome 15 open reading frame 40","-","-","IPR036591,YggU-like superfamily;IPR003746,Protein of unknown function DUF167","-","-","-"]
["CACTIN",5.585420084,2.146988299,1.37696369,4.577426427,{"v":2.02E-5,"d":"2.02E-05"},{"v":7.19e-05,"d":"7.19E-05"},"ENSG00000105298","G3R9X4,Cactin, spliceosome C complex subunit","XP_004059785.2,cactin;XP_018870968.1,-","PF10312,Conserved mid region of cactin;PF09732,Cactus-binding C-terminus of cactin protein","IPR019134,Cactin, C-terminal;IPR018816,Cactin, central domain","-","-","-"]
["NFYB",12.02633101,4.628014761,1.376400708,5.398007762,{"v":7.89e-07,"d":"7.89E-07"},{"v":3.81e-06,"d":"3.81E-06"},"ENSG00000120837","G1R437,Nuclear transcription factor Y subunit beta","-","PF00808,Histone-like transcription factor (CBF/NF-Y) and archaeal histone","-","-","-","-"]
["PCNX1",3.31009356,1.274192278,1.375856547,5.293002775,{"v":1.29e-06,"d":"1.29E-06"},{"v":5.97e-06,"d":"5.97E-06"},"ENSG00000100731","K7D0I2,Pecanex homolog","XP_016781768.1,pecanex-like protein 1 isoform X2","PF05041,Pecanex protein (C-terminus)","IPR007735,Pecanex","KOG3604,Pecanex;ENOG410XPRI,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["AC013461.1",4.439794006,1.709672298,1.375479884,5.437155822,{"v":8.15e-07,"d":"8.15E-07"},{"v":3.92e-06,"d":"3.92E-06"},"ENSG00000091436","K7DQ37,Sterile alpha motif and leucine zipper containing kinase AZK","XP_016805540.1,-;XP_003309476.2,-","PF00536,SAM domain (Sterile alpha motif);PF07714,Protein tyrosine kinase","IPR032938,Mitogen-activated protein kinase kinase kinase MLT;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR001660,Sterile alpha motif domain;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0192,Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs","GO:0016301,molecular_function,kinase activity;GO:0000165,biological_process,MAPK cascade;GO:0004709,molecular_function,MAP kinase kinase kinase activity;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity;GO:0005622,cellular_component,intracellular;GO:0000186,biological_process,activation of MAPKK activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation","K04424,ko04530,Tight junction;K04424,ko04010,MAPK signaling pathway"]
["AL513122.2",38.13850696,14.70001997,1.374499547,5.902054561,{"v":1.41e-07,"d":"1.41E-07"},{"v":8e-07,"d":"8.00E-07"},"ENSG00000283430","K7DBX7,Gelsolin","XP_009455478.1,-;XP_009455479.1,-;XP_001160857.1,gelsolin isoform X4;XP_009455481.1,-;XP_009455477.1,-;XP_009455480.1,-;XP_009455476.1,-;XP_009455475.1,-","PF00626,elsolin repeat","IPR007123,Gelsolin-like domain;IPR007122,Villin/Gelsolin;IPR029006,ADF-H/Gelsolin-like domain superfamily;IPR030004,Gelsolin","KOG0443,Actin regulatory proteins (gelsolin/villin family);ENOG410XR0A,-","GO:0045010,biological_process,actin nucleation;GO:0051015,molecular_function,actin filament binding;GO:0051016,biological_process,barbed-end actin filament capping;GO:0051014,biological_process,actin filament severing;GO:0005509,molecular_function,calcium ion binding","K05768,ko04810,Regulation of actin cytoskeleton;K05768,ko04666,Fc gamma R-mediated phagocytosis;K05768,ko05203,Viral carcinogenesis"]
["NBL1",2.467118393,0.945637648,1.374188686,2.734765449,0.011418275,0.021381696,"ENSG00000158747","G1R8Q8,Uncharacterized protein","XP_003271591.1,neuroblastoma suppressor of tumorigenicity 1 isoform X1","PF03045,AN domain","IPR004133,DAN;IPR006207,Cystine knot, C-terminal;IPR016728,Neuroblastoma suppressor of tumourigenicity 1;IPR029034,Cystine-knot cytokine","ENOG4111SRK,-;ENOG410IWXT,-","GO:0048263,biological_process,determination of dorsal identity;GO:0036122,molecular_function,BMP binding;GO:0016015,molecular_function,morphogen activity;GO:0030514,biological_process,negative regulation of BMP signaling pathway;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0007399,biological_process,nervous system development;GO:0090027,biological_process,negative regulation of monocyte chemotaxis;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0035582,biological_process,sequestering of BMP in extracellular matrix;GO:0005576,cellular_component,extracellular region;GO:0048812,biological_process,neuron projection morphogenesis","K19558,ko04350,TGF-beta signaling pathway"]
["DYNC2H1",0.598471383,0.229391939,1.374188686,2.734765449,0.011418275,0.021381696,"ENSG00000187240","B0I1S0,DYNC2H1 variant protein","-","PF12774,Hydrolytic ATP binding site of dynein motor region D1;PF12777,Microtubule-binding stalk of dynein motor;PF07728,AAA domain (dynein-related subfamily);PF03028,ynein heavy chain and region D6 of dynein motor;PF12780,P-loop containing dynein motor region D4;PF08393,ynein heavy chain, N-terminal region 2;PF08385,ynein heavy chain, N-terminal region 1;PF12781,ATP-binding dynein motor region D5;PF12775,P-loop containing dynein motor region D3","IPR035699,Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;IPR024743,Dynein heavy chain, coiled coil stalk;IPR026983,Dynein heavy chain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004273,Dynein heavy chain domain;IPR013602,Dynein heavy chain, domain-2;IPR026815,Cytoplasmic dynein 2 heavy chain 1;IPR011704,ATPase, dynein-related, AAA domain;IPR035706,Dynein heavy chain, ATP-binding dynein motor region D5;IPR003593,AAA+ ATPase domain;IPR013594,Dynein heavy chain, domain-1;IPR024317,Dynein heavy chain, AAA module D4","COG5245,Dynein, heavy chain;KOG3595,Dyneins, heavy chain","GO:0007018,biological_process,microtubule-based movement;GO:0030286,cellular_component,dynein complex;GO:0016887,molecular_function,ATPase activity;GO:0003777,molecular_function,microtubule motor activity;GO:0005524,molecular_function,ATP binding","-"]
["RP11-449J21.5",3.744443815,1.43523191,1.374188686,2.734765449,0.011418275,0.021381696,"-","-","-","-","-","-","-","-"]
["PSMB5",20.71890219,7.982735489,1.373829576,4.711396834,{"v":1.33E-5,"d":"1.33E-05"},{"v":4.94e-05,"d":"4.94E-05"},"ENSG00000100804","K7CQQ2,Proteasome subunit beta type","XP_016781359.1,-","PF00227,Proteasome subunit","IPR023333,Proteasome B-type subunit;IPR037558,Proteasome subunit beta 5;IPR016050,Proteasome beta-type subunit, conserved site;IPR000243,Peptidase T1A, proteasome beta-subunit;IPR029055,Nucleophile aminohydrolases, N-terminal;IPR001353,Proteasome, subunit alpha/beta","KOG0175,20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2;ENOG410XQRP,-","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0051603,biological_process,proteolysis involved in cellular protein catabolic process;GO:0005737,cellular_component,cytoplasm;GO:0000502,cellular_component,proteasome complex;GO:0005839,cellular_component,proteasome core complex;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006979,biological_process,response to oxidative stress;GO:0005813,cellular_component,centrosome;GO:0004298,molecular_function,threonine-type endopeptidase activity;GO:0004175,molecular_function,endopeptidase activity;GO:0005634,cellular_component,nucleus;GO:0008233,molecular_function,peptidase activity;GO:0005654,cellular_component,nucleoplasm","K02737,ko03050,Proteasome"]
["SDHAP2",7.238914974,2.783747409,1.373281922,3.435956061,1.708609E-3,0.00392193,"ENSG00000215837","H2PF44,Uncharacterized protein","-","PF02910,umarate reductase flavoprotein C-term","IPR015939,Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal;IPR037099,Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily","COG1053,Succinate dehydrogenase/fumarate reductase, flavoprotein subunit;KOG2403,Succinate dehydrogenase, flavoprotein subunit","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity","-"]
["SRPK2",11.38430597,4.392271382,1.372913113,5.670267003,{"v":3.22E-7,"d":"3.22E-07"},{"v":1.68E-6,"d":"1.68E-06"},"ENSG00000135250","H2R3P3,Uncharacterized protein","-","PF00069,Protein kinase domain","-","-","-","-"]
["ARHGAP11B",2.223603277,0.856263358,1.372901629,3.903822614,3.1911E-4,0.000862228,"ENSG00000187951","H0XX99,Rho GTPase activating protein 11B","-","PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain","KOG2710,Rho GTPase-activating protein;ENOG410YVI5,-","GO:0007165,biological_process,signal transduction","-"]
["C22orf39",8.071524454,3.114761252,1.372311013,5.31200912,{"v":1.5E-6,"d":"1.50E-06"},{"v":6.88e-06,"d":"6.88E-06"},"ENSG00000242259","G3QNB3,Chromosome 22 open reading frame 39","XP_004063066.1,UPF0545 protein C22orf39 homolog isoform X1","PF11326,Protein of unknown function (DUF3128)","IPR021475,Protein of unknown function DUF3128","-","-","-"]
["CCNG2",4.53907242,1.751976715,1.37109172,4.608533818,{"v":2.85e-05,"d":"2.85E-05"},{"v":9.78e-05,"d":"9.78E-05"},"ENSG00000138764","H2QPR4,Cyclin G2","XP_009445965.1,-;XP_001147453.1,-","PF00134,Cyclin, N-terminal domain","IPR028895,Cyclin-G2;IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","COG5024,Cyclin;KOG0653,Cyclin B and related kinase-activating proteins","GO:0051726,biological_process,regulation of cell cycle","K10146,ko04115,p53 signaling pathway;K10146,ko04068,FoxO signaling pathway"]
["DYNC2LI1",4.782112064,1.844792025,1.370619445,4.01194873,2.80914E-4,0.000770801,"ENSG00000138036","G3SFZ5,Dynein cytoplasmic 2 light intermediate chain 1","XP_004029201.1,cytoplasmic dynein 2 light intermediate chain 1 isoform X1","PF05783,ynein light intermediate chain (DLIC)","IPR022780,Dynein family light intermediate chain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","-","-"]
["PRUNE1",5.271723761,2.032518921,1.370123583,3.583856786,0.000896798,0.002182394,"ENSG00000143363","K7C1K7,Prune homolog","-","PF01368,HH family;PF02833,HHA2 domain","IPR004097,DHHA2 domain;IPR038222,DHHA2 domain superfamily;IPR001667,DDH domain","-","GO:0016462,molecular_function,pyrophosphatase activity;GO:0050767,biological_process,regulation of neurogenesis;GO:0031113,biological_process,regulation of microtubule polymerization;GO:0005737,cellular_component,cytoplasm;GO:0015631,molecular_function,tubulin binding;GO:0016311,biological_process,dephosphorylation;GO:0005829,cellular_component,cytosol;GO:0016791,molecular_function,phosphatase activity","-"]
["FARSB",14.59016031,5.640985401,1.36937592,5.127833258,{"v":2.95e-06,"d":"2.95E-06"},{"v":1.26E-5,"d":"1.26E-05"},"ENSG00000116120","G1REX9,Phenylalanyl-tRNA synthetase beta subunit","-","PF03483,B3/4 domain;PF03484,tRNA synthetase B5 domain","IPR004531,Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic;IPR009061,Putative DNA-binding domain superfamily;IPR005146,B3/B4 tRNA-binding domain;IPR020825,Phenylalanyl-tRNA synthetase, B3/B4;IPR005147,tRNA synthetase, B5-domain","KOG2472,Phenylalanyl-tRNA synthetase beta subunit;COG0072,Phenylalanyl-tRNA synthetase beta subunit","GO:0006432,biological_process,phenylalanyl-tRNA aminoacylation;GO:0005737,cellular_component,cytoplasm;GO:0004826,molecular_function,phenylalanine-tRNA ligase activity;GO:0003723,molecular_function,RNA binding;GO:0000287,molecular_function,magnesium ion binding;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","K01890,ko00970,Aminoacyl-tRNA biosynthesis"]
["TMEM19",1.573795661,0.606035965,1.369053655,2.969402239,0.008432619,0.016354077,"ENSG00000139291","A0A024RBA1,Transmembrane protein 19, isoform CRA_a","NP_060749.2,transmembrane protein 19","PF01940,Integral membrane protein DUF92","IPR002794,Protein of unknown function DUF92, TMEM19","ENOG410XQMT,-;KOG4491,Predicted membrane protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["FTH1P8",19.86534289,7.649730235,1.369053655,2.969402239,0.008432619,0.016354077,"ENSG00000219507","L9LCY6,Ferritin","-","PF00210,erritin-like domain","IPR009040,Ferritin-like diiron domain;IPR001519,Ferritin;IPR012347,Ferritin-like;IPR009078,Ferritin-like superfamily;IPR008331,Ferritin/DPS protein domain","-","GO:0046872,molecular_function,metal ion binding;GO:0008199,molecular_function,ferric iron binding;GO:0005623,cellular_component,cell;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0006826,biological_process,iron ion transport","-"]
["LRP6",8.269870591,3.201509911,1.368193319,5.911675387,{"v":1.43E-7,"d":"1.43E-07"},{"v":8.12e-07,"d":"8.12E-07"},"ENSG00000070018","H2Q5G9,Low-density lipoprotein receptor-related protein","XP_001152103.1,low-density lipoprotein receptor-related protein 6 isoform X1","PF14670,Coagulation Factor Xa inhibitory site;PF00057,Low-density lipoprotein receptor domain class A;PF00058,Low-density lipoprotein receptor repeat class B","IPR017049,Low density lipoprotein receptor-related protein 5/6;IPR000033,LDLR class B repeat;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR011042,Six-bladed beta-propeller, TolB-like;IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR000742,EGF-like domain;IPR036055,LDL receptor-like superfamily","ENOG410XSY5,-;ENOG410IPT4,-","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0019210,molecular_function,kinase inhibitor activity;GO:0021794,biological_process,thalamus development;GO:0014029,biological_process,neural crest formation;GO:0016055,biological_process,Wnt signaling pathway;GO:0005102,molecular_function,signaling receptor binding;GO:0060026,biological_process,convergent extension;GO:0005041,molecular_function,low-density lipoprotein particle receptor activity;GO:0060325,biological_process,face morphogenesis;GO:0044332,biological_process,Wnt signaling pathway involved in dorsal/ventral axis specification;GO:0060535,biological_process,trachea cartilage morphogenesis;GO:0071901,biological_process,negative regulation of protein serine/threonine kinase activity;GO:0005769,cellular_component,early endosome;GO:0045202,cellular_component,synapse;GO:0071936,molecular_function,coreceptor activity involved in Wnt signaling pathway;GO:0009986,cellular_component,cell surface;GO:0016021,cellular_component,integral component of membrane;GO:0007268,biological_process,chemical synaptic transmission;GO:0021987,biological_process,cerebral cortex development;GO:0060021,biological_process,roof of mouth development;GO:0051091,biological_process,positive regulation of DNA binding transcription factor activity;GO:0034392,biological_process,negative regulation of smooth muscle cell apoptotic process;GO:0042803,molecular_function,protein homodimerization activity;GO:0019534,molecular_function,toxin transmembrane transporter activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0090245,biological_process,axis elongation involved in somitogenesis;GO:0042475,biological_process,odontogenesis of dentin-containing tooth;GO:0072659,biological_process,protein localization to plasma membrane;GO:0045787,biological_process,positive regulation of cell cycle;GO:0030901,biological_process,midbrain development;GO:0001843,biological_process,neural tube closure;GO:0090244,biological_process,Wnt signaling pathway involved in somitogenesis;GO:1990851,cellular_component,Wnt-Frizzled-LRP5/6 complex;GO:0005109,molecular_function,frizzled binding;GO:2000055,biological_process,positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification;GO:0035261,biological_process,external genitalia morphogenesis;GO:0060070,biological_process,canonical Wnt signaling pathway;GO:1990909,cellular_component,Wnt signalosome;GO:0005794,cellular_component,Golgi apparatus;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0060059,biological_process,embryonic retina morphogenesis in camera-type eye;GO:0034185,molecular_function,apolipoprotein binding;GO:0003344,biological_process,pericardium morphogenesis;GO:0016020,cellular_component,membrane;GO:0005901,cellular_component,caveola;GO:0042802,molecular_function,identical protein binding;GO:1901998,biological_process,toxin transport;GO:0009880,biological_process,embryonic pattern specification;GO:0060828,biological_process,regulation of canonical Wnt signaling pathway;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0042813,molecular_function,Wnt-activated receptor activity;GO:0017147,molecular_function,Wnt-protein binding;GO:0043235,cellular_component,receptor complex;GO:0043025,cellular_component,neuronal cell body;GO:0071397,biological_process,cellular response to cholesterol;GO:0090009,biological_process,primitive streak formation;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0090118,biological_process,receptor-mediated endocytosis involved in cholesterol transport;GO:0014033,biological_process,neural crest cell differentiation;GO:0030917,biological_process,midbrain-hindbrain boundary development;GO:0005886,cellular_component,plasma membrane;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway;GO:0007275,biological_process,multicellular organism development;GO:0021587,biological_process,cerebellum morphogenesis","K03068,ko04150,mTOR signaling pathway;K03068,ko04310,Wnt signaling pathway"]
["XXbac-BPG32J3.20",7.637011534,2.950657095,1.367558756,3.717866476,0.000756638,0.001877073,"ENSG00000204422","B7ZCA4,Lymphocyte antigen 6 family member G6E","-","-","-","ENOG41118E3,-;ENOG410JD5T,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CUL9",1.453718953,0.561662913,1.367558756,3.717866476,0.000756638,0.001877073,"ENSG00000112659","H2QT22,Uncharacterized protein","XP_518908.2,cullin-9 isoform X2","PF01485,IBR domain, a half RING-finger domain;PF03256,Anaphase-promoting complex, subunit 10 (APC10);PF00888,Cullin family;PF11515,Mouse development and cellular proliferation protein Cullin-7","IPR019559,Cullin protein, neddylation domain;IPR008979,Galactose-binding-like domain superfamily;IPR002867,IBR domain;IPR017907,Zinc finger, RING-type, conserved site;IPR016158,Cullin homology domain;IPR031222,Cullin-9;IPR004939,APC10/DOC domain;IPR001373,Cullin, N-terminal;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR016024,Armadillo-type fold;IPR016157,Cullin, conserved site;IPR036317,Cullin homology domain superfamily;IPR014722,Ribosomal protein L2, domain 2;IPR021097,CPH domain","ENOG410XP9Y,-;KOG1815,Predicted E3 ubiquitin ligase","GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016567,biological_process,protein ubiquitination;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0046872,molecular_function,metal ion binding;GO:0007088,biological_process,regulation of mitotic nuclear division;GO:0005829,cellular_component,cytosol;GO:0031461,cellular_component,cullin-RING ubiquitin ligase complex","-"]
["KLC2",7.107768539,2.750961576,1.367444428,4.801146621,{"v":1.29E-5,"d":"1.29E-05"},{"v":4.79e-05,"d":"4.79E-05"},"ENSG00000174996","H2Q459,Kinesin light chain 2","XP_009421780.1,-;XP_001170851.1,-;XP_001170884.1,-;XP_001170836.2,-;XP_522069.2,kinesin light chain 2 isoform X1;XP_009421781.1,-;XP_009421779.1,-","PF13424,Tetratricopeptide repeat","IPR015792,Kinesin light chain repeat;IPR002151,Kinesin light chain;IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR011990,Tetratricopeptide-like helical domain superfamily","KOG1840,Kinesin light chain;COG0457,FOG: TPR repeat","GO:0005871,cellular_component,kinesin complex;GO:0032991,cellular_component,protein-containing complex;GO:0005886,cellular_component,plasma membrane;GO:0005739,cellular_component,mitochondrion;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol;GO:0003777,molecular_function,microtubule motor activity;GO:0005654,cellular_component,nucleoplasm","K10407,ko05132,Salmonella infection"]
["CREB3L2",3.75591263,1.454127715,1.366632481,4.570091004,{"v":2.44E-5,"d":"2.44E-05"},{"v":8.5e-05,"d":"8.50E-05"},"ENSG00000182158","G3QNM1,cAMP responsive element binding protein 3 like 2","XP_018887030.1,cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1","PF00170,bZIP transcription factor","IPR029804,cAMP-responsive element-binding protein 3-like protein 2;IPR004827,Basic-leucine zipper domain","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0035497,molecular_function,cAMP response element binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0051216,biological_process,cartilage development;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0002062,biological_process,chondrocyte differentiation;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005654,cellular_component,nucleoplasm","K09048,ko04915,Estrogen signaling pathway;K09048,ko04668,TNF signaling pathway;K09048,ko05031,Amphetamine addiction;K09048,ko04728,Dopaminergic synapse;K09048,ko05030,Cocaine addiction;K09048,ko04931,Insulin resistance;K09048,ko04922,Glucagon signaling pathway;K09048,ko04911,Insulin secretion;K09048,ko05215,Prostate cancer;K09048,ko05161,Hepatitis B;K09048,ko04916,Melanogenesis;K09048,ko05203,Viral carcinogenesis;K09048,ko05034,Alcoholism;K09048,ko04918,Thyroid hormone synthesis;K09048,ko04151,PI3K-Akt signaling pathway;K09048,ko04211,Longevity regulating pathway;K09048,ko04022,cGMP-PKG signaling pathway;K09048,ko04962,Vasopressin-regulated water reabsorption;K09048,ko04152,AMPK signaling pathway;K09048,ko05016,Huntington's disease;K09048,ko04261,Adrenergic signaling in cardiomyocytes;K09048,ko04024,cAMP signaling pathway;K09048,ko04925,Aldosterone synthesis and secretion;K09048,ko04725,Cholinergic synapse"]
["DLST",18.57929928,7.201394397,1.366420481,5.896266736,{"v":1.74E-7,"d":"1.74E-07"},{"v":9.66e-07,"d":"9.66E-07"},"ENSG00000119689","K7BEL6,Dihydrolipoamide S-succinyltransferase","XP_510068.3,-","PF00364,Biotin-requiring enzyme;PF00198,2-oxoacid dehydrogenases acyltransferase (catalytic domain)","IPR006255,Dihydrolipoamide succinyltransferase;IPR011053,Single hybrid motif;IPR023213,Chloramphenicol acetyltransferase-like domain superfamily;IPR001078,2-oxoacid dehydrogenase acyltransferase, catalytic domain;IPR000089,Biotin/lipoyl attachment;IPR003016,2-oxo acid dehydrogenase, lipoyl-binding site","KOG0559,Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit);COG0508,Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes","GO:0016740,molecular_function,transferase activity;GO:0045252,cellular_component,oxoglutarate dehydrogenase complex;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0004149,molecular_function,dihydrolipoyllysine-residue succinyltransferase activity;GO:0106077,biological_process,histone succinylation;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0006099,biological_process,tricarboxylic acid cycle;GO:0005634,cellular_component,nucleus","-"]
["P2RY2",4.14995011,1.603386309,1.365363579,3.170736817,0.003978429,0.008383509,"ENSG00000175591","H2Q4D2,Uncharacterized protein","XP_001174775.1,-;XP_522101.1,-;XP_016777053.1,-;XP_016777057.1,-;XP_016777054.1,-;XP_016777058.1,-;XP_009421998.1,-;XP_016777056.1,-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR000356,P2Y2 purinoceptor;IPR000276,G protein-coupled receptor, rhodopsin-like;IPR017452,GPCR, rhodopsin-like, 7TM","ENOG410XQNZ,-;ENOG410IIAQ,-","GO:0070257,biological_process,positive regulation of mucus secretion;GO:0035589,biological_process,G-protein coupled purinergic nucleotide receptor signaling pathway;GO:0097746,biological_process,regulation of blood vessel diameter;GO:0045028,molecular_function,G-protein coupled purinergic nucleotide receptor activity;GO:0016020,cellular_component,membrane;GO:0004871,molecular_function,signal transducer activity;GO:0016021,cellular_component,integral component of membrane;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0007200,biological_process,phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007165,biological_process,signal transduction","K04269,ko04750,Inflammatory mediator regulation of TRP channels;K04269,ko04080,Neuroactive ligand-receptor interaction"]
["SMIM13",2.532638068,0.978517114,1.365363579,3.170736817,0.003978429,0.008383509,"ENSG00000224531","H9ES99,UPF0766 protein C6orf228","NP_001248648.1,small integral membrane protein 13","PF15938,omain of unknown function (DUF4750)","IPR031851,Protein of unknown function DUF4750","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RBMS2",11.03023276,4.279533922,1.365131613,6.094116582,{"v":8.65E-8,"d":"8.65E-08"},{"v":5.16e-07,"d":"5.16E-07"},"ENSG00000076067","H2Q693,RNA binding motif, single stranded interacting protein 2","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR002343,Paraneoplastic encephalomyelitis antigen","ENOG410XRB5,-;KOG4733,FOG: RRM domain","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["CTC-432M15.3",4.494396618,1.74261804,1.364147763,4.377639043,{"v":5.92e-05,"d":"5.92E-05"},1.88729E-4,"ENSG00000273217","E9PCH4,Uncharacterized protein","-","PF00595,PDZ domain (Also known as DHR or GLGF);PF00617,RasGEF domain;PF00788,Ras association (RalGDS/AF-6) domain;PF00027,Cyclic nucleotide-binding domain;PF00618,RasGEF N-terminal motif;PF14636,olliculin-interacting protein N-terminus","IPR000651,Ras-like guanine nucleotide exchange factor, N-terminal;IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR036034,PDZ superfamily;IPR014710,RmlC-like jelly roll fold;IPR000159,Ras-associating (RA) domain;IPR000595,Cyclic nucleotide-binding domain;IPR001478,PDZ domain;IPR018490,Cyclic nucleotide-binding-like;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR028084,Folliculin-interacting protein, N-terminal domain","KOG3542,cAMP-regulated guanine nucleotide exchange factor;ENOG410XS6B,-","GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0065009,biological_process,regulation of molecular function;GO:0005813,cellular_component,centrosome;GO:0005829,cellular_component,cytosol;GO:0007165,biological_process,signal transduction","-"]
["EXO5",6.835042992,2.649284,1.363646294,3.953226975,3.67518E-4,0.000980352,"ENSG00000164002","G3S9X2,Exonuclease 5","XP_004025592.1,exonuclease V;XP_018871862.1,-;XP_018871851.1,-;XP_018871856.1,-","PF09810,xonuclease V - a 5' deoxyribonuclease","IPR019190,Exonuclease V","-","GO:0051539,molecular_function,4 iron, 4 sulfur cluster binding;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0045145,molecular_function,single-stranded DNA 5'-3' exodeoxyribonuclease activity;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0036297,biological_process,interstrand cross-link repair;GO:0005654,cellular_component,nucleoplasm","-"]
["MORN4",8.413197823,3.260981738,1.363646294,3.953226975,3.67518E-4,0.000980352,"ENSG00000171160","G3RM33,MORN repeat containing 4","-","PF02493,MORN repeat","IPR003409,MORN motif","-","GO:0005737,cellular_component,cytoplasm;GO:0032426,cellular_component,stereocilium tip;GO:0048678,biological_process,response to axon injury;GO:0032433,cellular_component,filopodium tip","-"]
["MAP1B",8.949408484,3.476397596,1.363507959,6.31081669,{"v":4.03e-08,"d":"4.03E-08"},{"v":2.59e-07,"d":"2.59E-07"},"ENSG00000131711","A0A024RAM4,Microtubule-associated protein 1B, isoform CRA_b","-","PF00414,Neuraxin and MAP1B repeat","IPR000102,Neuraxin/MAP1B repeat;IPR027321,Microtubule-associated protein 1B;IPR026074,Microtubule associated protein 1","ENOG410XRYM,-;KOG3592,Microtubule-associated proteins","GO:0007399,biological_process,nervous system development;GO:0005874,cellular_component,microtubule;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0008017,molecular_function,microtubule binding","-"]
["ACAD9",9.164743301,3.559089882,1.362616874,4.827817967,{"v":1.08E-5,"d":"1.08E-05"},{"v":4.08e-05,"d":"4.08E-05"},"ENSG00000177646","H2QNB4,Acyl-CoA dehydrogenase family member 9","XP_001140269.1,-","PF00441,Acyl-CoA dehydrogenase, C-terminal domain;PF02771,Acyl-CoA dehydrogenase, N-terminal domain;PF02770,Acyl-CoA dehydrogenase, middle domain","IPR036250,Acyl-CoA dehydrogenase-like, C-terminal;IPR013786,Acyl-CoA dehydrogenase/oxidase, N-terminal;IPR009100,Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily;IPR037069,Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily;IPR009075,Acyl-CoA dehydrogenase/oxidase C-terminal;IPR006091,Acyl-CoA oxidase/dehydrogenase, central domain;IPR006089,Acyl-CoA dehydrogenase, conserved site","COG1960,Acyl-CoA dehydrogenases;KOG0137,Very-long-chain acyl-CoA dehydrogenase","GO:0001676,biological_process,long-chain fatty acid metabolic process;GO:0016627,molecular_function,oxidoreductase activity, acting on the CH-CH group of donors;GO:0030425,cellular_component,dendrite;GO:0004466,molecular_function,long-chain-acyl-CoA dehydrogenase activity;GO:0032981,biological_process,mitochondrial respiratory chain complex I assembly;GO:0051791,biological_process,medium-chain fatty acid metabolic process;GO:0070991,molecular_function,medium-chain-acyl-CoA dehydrogenase activity;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0031966,cellular_component,mitochondrial membrane;GO:0016491,molecular_function,oxidoreductase activity;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0005634,cellular_component,nucleus;GO:0003995,molecular_function,acyl-CoA dehydrogenase activity","-"]
["ZNF575",4.200877803,1.627130702,1.362583778,3.347090865,3.116237E-3,0.00670539,"ENSG00000176472","B3KQ07,Zinc finger protein 575","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["MTAP",1.559565844,0.605248205,1.362120223,4.057823127,0.000216051,0.000607214,"ENSG00000099810","A0A1D5QT52,S-methyl-5'-thioadenosine phosphorylase","-","-","IPR018099,Purine phosphorylase, family 2, conserved site;IPR035994,Nucleoside phosphorylase superfamily;IPR000845,Nucleoside phosphorylase domain;IPR010044,Methylthioadenosine phosphorylase  (MTAP)","-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0009116,biological_process,nucleoside metabolic process;GO:0005737,cellular_component,cytoplasm;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0016763,molecular_function,transferase activity, transferring pentosyl groups;GO:0019509,biological_process,L-methionine salvage from methylthioadenosine;GO:0006166,biological_process,purine ribonucleoside salvage;GO:0017061,molecular_function,S-methyl-5-thioadenosine phosphorylase activity;GO:0005634,cellular_component,nucleus","-"]
["NUDT21",16.83039659,6.548866302,1.360974569,6.139821697,{"v":7.01e-08,"d":"7.01E-08"},{"v":4.26e-07,"d":"4.26E-07"},"ENSG00000167005","I3M6R7,Nudix hydrolase 21","XP_005318251.1,-","PF13869,Nucleotide hydrolase","IPR015797,NUDIX hydrolase-like domain superfamily;IPR016706,Cleavage/polyadenylation specificity factor subunit 5;IPR000086,NUDIX hydrolase domain","KOG1689,mRNA cleavage factor I subunit;ENOG410XS8Z,-","GO:1900365,biological_process,positive regulation of mRNA polyadenylation;GO:0005849,cellular_component,mRNA cleavage factor complex;GO:0005815,cellular_component,microtubule organizing center;GO:0051290,biological_process,protein heterotetramerization;GO:0005634,cellular_component,nucleus;GO:0003729,molecular_function,mRNA binding;GO:0042826,molecular_function,histone deacetylase binding;GO:0016787,molecular_function,hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0006378,biological_process,mRNA polyadenylation;GO:0005813,cellular_component,centrosome;GO:0042802,molecular_function,identical protein binding;GO:0003682,molecular_function,chromatin binding;GO:0017091,molecular_function,AU-rich element binding;GO:0016604,cellular_component,nuclear body;GO:0006397,biological_process,mRNA processing;GO:0051262,biological_process,protein tetramerization;GO:0005847,cellular_component,mRNA cleavage and polyadenylation specificity factor complex;GO:0031442,biological_process,positive regulation of mRNA 3'-end processing;GO:0003723,molecular_function,RNA binding;GO:0042382,cellular_component,paraspeckles;GO:0031439,biological_process,positive regulation of mRNA cleavage;GO:0098789,biological_process,pre-mRNA cleavage required for polyadenylation","-"]
["DCLRE1C",2.40237896,0.932333546,1.360414409,3.504007606,1.596358E-3,0.003685957,"ENSG00000152457","E5FGH4,Artemis","NP_001266677.1,protein artemis","PF12706,Beta-lactamase superfamily domain;PF07522,NA repair metallo-beta-lactamase","IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR001279,Metallo-beta-lactamase;IPR011084,DNA repair metallo-beta-lactamase","KOG1361,Predicted hydrolase involved in interstrand cross-link repair;COG1236,Predicted exonuclease of the beta-lactamase fold involved in RNA processing","-","-"]
["LPCAT4",3.166795019,1.228993959,1.360414409,3.504007606,1.596358E-3,0.003685957,"ENSG00000176454","H2Q941,Lysophosphatidylcholine acyltransferase 4","XP_510281.2,lysophospholipid acyltransferase LPCAT4","PF01553,Acyltransferase","IPR002123,Phospholipid/glycerol acyltransferase","KOG4666,Predicted phosphate acyltransferase, contains PlsC domain;ENOG410XSIQ,-","GO:0071617,molecular_function,lysophospholipid acyltransferase activity;GO:0006644,biological_process,phospholipid metabolic process;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016021,cellular_component,integral component of membrane","K13512,ko00565,Ether lipid metabolism;K13512,ko00564,Glycerophospholipid metabolism"]
["C2orf69",3.537581308,1.37289153,1.360414409,3.504007606,1.596358E-3,0.003685957,"ENSG00000178074","G3QSA0,Chromosome 2 open reading frame 69","XP_018878363.1,-","PF10561,Uncharacterised protein family UPF0565","IPR018881,Uncharacterised protein family UPF0565","-","-","-"]
["GRAMD1C",1.944900089,0.754791657,1.360414409,3.504007606,1.596358E-3,0.003685957,"ENSG00000178075","G1QXN3,GRAM domain containing 1C","XP_003261874.1,GRAM domain-containing protein 1C isoform X1","PF02893,RAM domain;PF16016,omain of unknown function (DUF4782)","IPR004182,GRAM domain;IPR031968,VASt domain;IPR011993,PH-like domain superfamily","ENOG410XRQQ,-;KOG1032,Uncharacterized conserved protein, contains GRAM domain","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["FAM83H-AS1",7.101879094,2.762317281,1.360120704,4.668803899,{"v":2.31e-05,"d":"2.31E-05"},{"v":8.09e-05,"d":"8.09E-05"},"ENSG00000203499","A0A1B0GTG1,IQ motif and ankyrin repeat-containing 1","-","-","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily;IPR000048,IQ motif, EF-hand binding site","-","-","-"]
["GDI2",86.5525449,33.71691785,1.359880691,7.92753871,{"v":9.38e-10,"d":"9.38E-10"},{"v":8.67e-09,"d":"8.67E-09"},"ENSG00000057608","G1RL94,Rab GDP dissociation inhibitor","-","PF00996,P dissociation inhibitor","-","-","-","-"]
["BCAN",5.2972249,2.059940539,1.359653411,4.246565178,1.18334E-4,0.000351875,"ENSG00000132692","A8K144,cDNA FLJ76746, highly similar to Homo sapiens brevican","-","PF00084,Sushi repeat (SCR repeat);PF00008,-like domain;PF00193,xtracellular link domain;PF07686,Immunoglobulin V-set domain;PF00059,Lectin C-type domain","IPR016187,C-type lectin fold;IPR003006,Immunoglobulin/major histocompatibility complex, conserved site;IPR018378,C-type lectin, conserved site;IPR016186,C-type lectin-like/link domain superfamily;IPR000538,Link domain;IPR035976,Sushi/SCR/CCP superfamily;IPR003599,Immunoglobulin subtype;IPR000436,Sushi/SCR/CCP domain;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR001304,C-type lectin-like;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR013106,Immunoglobulin V-set domain;IPR007110,Immunoglobulin-like domain","ENOG410IMD6,-;ENOG410XW3U,-","GO:0005540,molecular_function,hyaluronic acid binding;GO:0007155,biological_process,cell adhesion","-"]
["CASP8AP2",8.340602337,3.248162899,1.35938625,5.592300919,{"v":5.49e-07,"d":"5.49E-07"},{"v":2.74E-6,"d":"2.74E-06"},"ENSG00000118412","A0A087WTW5,CASP8-associated protein 2","-","-","-","-","GO:0006919,biological_process,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0042802,molecular_function,identical protein binding;GO:0002020,molecular_function,protease binding;GO:0008656,molecular_function,cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0008625,biological_process,extrinsic apoptotic signaling pathway via death domain receptors","-"]
["CLEC16A",4.754187134,1.851654247,1.359063537,5.385626069,{"v":1.18e-06,"d":"1.18E-06"},{"v":5.5e-06,"d":"5.50E-06"},"ENSG00000038532","H2RAD6,Uncharacterized protein","XP_009428579.1,protein CLEC16A isoform X1","PF09758,Uncharacterised conserved protein","IPR019155,CLEC16A/TT9, N-terminal","ENOG410Y0P3,-;KOG2219,Uncharacterized conserved protein","GO:0005794,cellular_component,Golgi apparatus;GO:1904263,biological_process,positive regulation of TORC1 signaling;GO:1901097,biological_process,negative regulation of autophagosome maturation;GO:0032435,biological_process,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0009267,biological_process,cellular response to starvation;GO:1901098,biological_process,positive regulation of autophagosome maturation;GO:0005829,cellular_component,cytosol;GO:0036020,cellular_component,endolysosome membrane;GO:0031982,cellular_component,vesicle;GO:1904766,biological_process,negative regulation of macroautophagy by TORC1 signaling;GO:1901525,biological_process,negative regulation of mitophagy","-"]
["ZSWIM5",0.981889453,0.37936555,1.358823193,2.269828895,0.042538843,0.068430389,"ENSG00000162415","H2PYW9,Uncharacterized protein","-","-","IPR007527,Zinc finger, SWIM-type","KOG3615,Uncharacterized conserved protein;ENOG410XPZG,-","GO:0008270,molecular_function,zinc ion binding","-"]
["DPF1",1.23677159,0.477842524,1.358823193,2.269828895,0.042538843,0.068430389,"ENSG00000011332","A0A0A0MV96,Double PHD fingers 1","XP_003915508.1,-","PF00628,PHD-finger;PF14051,N-terminal domain of DPF2/REQ.","IPR013087,Zinc finger C2H2-type;IPR001965,Zinc finger, PHD-type;IPR036236,Zinc finger C2H2 superfamily;IPR038046,Zinc finger protein neuro-d4;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger;IPR025750,Requiem/DPF N-terminal domain","-","GO:0003676,molecular_function,nucleic acid binding;GO:0007399,biological_process,nervous system development;GO:0071565,cellular_component,nBAF complex;GO:0046872,molecular_function,metal ion binding;GO:0008270,molecular_function,zinc ion binding","-"]
["TEF",1.259067578,0.486456864,1.358823193,2.269828895,0.042538843,0.068430389,"ENSG00000167074","H2QLS2,Thyrotrophic embryonic factor","XP_525607.3,-","PF07716,Basic region leucine zipper","IPR029832,Thyrotroph embryonic factor;IPR004827,Basic-leucine zipper domain","KOG3119,Basic region leucine zipper transcription factor;ENOG410YJ8G,-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0007275,biological_process,multicellular organism development","-"]
["CARD8",2.277795159,0.887152516,1.357745864,4.413329039,{"v":6.87e-05,"d":"6.87E-05"},2.15603E-4,"ENSG00000105483","K7B4Y0,Caspase recruitment domain family, member 8","-","PF00619,Caspase recruitment domain;PF13553,unction to find","IPR001315,CARD domain;IPR025307,FIIND domain;IPR011029,Death-like domain superfamily","ENOG410ZQIE,-;KOG3573,Caspase, apoptotic cysteine protease","GO:0042981,biological_process,regulation of apoptotic process","-"]
["BCL3",5.713106518,2.223502712,1.357247488,3.773986345,0.000715667,0.001783681,"ENSG00000069399","K7DP79,B-cell CLL/lymphoma 3","-","PF12796,Ankyrin repeats (3 copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","GO:0033257,cellular_component,Bcl3/NF-kappaB2 complex;GO:0002268,biological_process,follicular dendritic cell differentiation;GO:0032991,cellular_component,protein-containing complex;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0019730,biological_process,antimicrobial humoral response;GO:0005886,cellular_component,plasma membrane;GO:0045064,biological_process,T-helper 2 cell differentiation;GO:0032996,cellular_component,Bcl3-Bcl10 complex;GO:0005634,cellular_component,nucleus;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0007249,biological_process,I-kappaB kinase/NF-kappaB signaling;GO:0046426,biological_process,negative regulation of JAK-STAT cascade;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0030330,biological_process,DNA damage response, signal transduction by p53 class mediator;GO:0030198,biological_process,extracellular matrix organization;GO:0005829,cellular_component,cytosol;GO:0042345,-,-;GO:0042742,biological_process,defense response to bacterium;GO:0042771,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0030496,cellular_component,midbody;GO:0003677,molecular_function,DNA binding;GO:0002467,biological_process,germinal center formation;GO:0042981,biological_process,regulation of apoptotic process;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0002455,biological_process,humoral immune response mediated by circulating immunoglobulin;GO:0006351,biological_process,transcription, DNA-templated;GO:0045082,biological_process,positive regulation of interleukin-10 biosynthetic process;GO:0042832,biological_process,defense response to protozoan;GO:0005654,cellular_component,nucleoplasm;GO:0045415,biological_process,negative regulation of interleukin-8 biosynthetic process;GO:0000060,biological_process,protein import into nucleus, translocation;GO:0042536,biological_process,negative regulation of tumor necrosis factor biosynthetic process;GO:0002315,biological_process,marginal zone B cell differentiation;GO:0048536,biological_process,spleen development;GO:0009615,biological_process,response to virus;GO:0051101,biological_process,regulation of DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0032729,biological_process,positive regulation of interferon-gamma production;GO:0008134,molecular_function,transcription factor binding;GO:0042088,biological_process,T-helper 1 type immune response;GO:0045727,biological_process,positive regulation of translation;GO:0010225,biological_process,response to UV-C","-"]
["SH3PXD2A",4.64578372,1.811681178,1.357172152,5.279670699,{"v":1.71e-06,"d":"1.71E-06"},{"v":7.71e-06,"d":"7.71E-06"},"ENSG00000107957","G3R7Q3,SH3 and PX domains 2A","-","PF00018,SH3 domain;PF00787,PX domain","-","-","-","-"]
["CENPO",10.198995,3.978515915,1.356746623,5.322126694,{"v":1.74e-06,"d":"1.74E-06"},{"v":7.83e-06,"d":"7.83E-06"},"ENSG00000138092","H2QHJ4,Centromere protein O","XP_003309008.1,centromere protein O isoform X1;XP_016803643.1,-","PF09496,Cenp-O kinetochore centromere component","IPR018464,Centromere protein O","ENOG4111RC4,-;ENOG410IJSQ,-","GO:0034508,biological_process,centromere complex assembly;GO:0000776,cellular_component,kinetochore","-"]
["TTC37",9.126310576,3.563319719,1.355760921,5.707182315,{"v":4.28e-07,"d":"4.28E-07"},{"v":2.18e-06,"d":"2.18E-06"},"ENSG00000198677","K7DTG0,Tetratricopeptide repeat domain 37","XP_016808482.1,tetratricopeptide repeat protein 37 isoform X1","PF13181,Tetratricopeptide repeat;PF13432,Tetratricopeptide repeat","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","KOG1127,TPR repeat-containing protein;ENOG410ZG1H,-","GO:0055087,cellular_component,Ski complex;GO:0005737,cellular_component,cytoplasm;GO:0035327,cellular_component,transcriptionally active chromatin;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K12600,ko03018,RNA degradation"]
["TMEM184A",4.411495332,1.721230141,1.355577583,4.631960431,{"v":2.8E-5,"d":"2.80E-05"},{"v":9.65e-05,"d":"9.65E-05"},"ENSG00000164855","A0A096NSI6,Transmembrane protein 184A","XP_009200753.1,-;XP_009200755.1,-;XP_009200754.1,-;XP_003895699.1,transmembrane protein 184A","PF03619,Organic solute transporter Ostalpha","IPR005178,Organic solute transporter subunit alpha/Transmembrane protein 184","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ACOT2",3.175396845,1.232332221,1.355324357,2.586041293,0.017419713,0.030890958,"ENSG00000119673","H2Q8K3,Acyl-CoA thioesterase 1","XP_016781865.1,acyl-coenzyme A thioesterase 2, mitochondrial isoform X2","PF04775,Acyl-CoA thioester hydrolase/BAAT N-terminal region;PF08840,BAAT / Acyl-CoA thioester hydrolase C terminal","IPR016662,Acyl-CoA thioesterase, long chain;IPR006862,Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase;IPR029058,Alpha/Beta hydrolase fold;IPR014940,BAAT/Acyl-CoA thioester hydrolase C-terminal","COG1073,Hydrolases of the alpha/beta superfamily;ENOG410II3X,-","GO:0005737,cellular_component,cytoplasm;GO:0006637,biological_process,acyl-CoA metabolic process;GO:0006631,biological_process,fatty acid metabolic process;GO:0016790,molecular_function,thiolester hydrolase activity;GO:0047617,molecular_function,acyl-CoA hydrolase activity","-"]
["CTD-2510F5.4",23.67203941,9.186825563,1.355324357,2.586041293,0.017419713,0.030890958,"-","-","-","-","-","-","-","-"]
["XAB2",7.723933679,3.01509269,1.3549884,4.698019379,{"v":1.9e-05,"d":"1.90E-05"},{"v":6.8e-05,"d":"6.80E-05"},"ENSG00000076924","K7BVP4,XPA binding protein 2","XP_016790371.1,-","PF13181,Tetratricopeptide repeat","IPR003107,HAT (Half-A-TPR) repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","ENOG410XPD9,-;KOG2047,mRNA splicing factor","GO:0071007,cellular_component,U2-type catalytic step 2 spliceosome;GO:0005634,cellular_component,nucleus;GO:0071013,cellular_component,catalytic step 2 spliceosome;GO:0006351,biological_process,transcription, DNA-templated;GO:0006396,biological_process,RNA processing;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0001824,biological_process,blastocyst development;GO:0006283,biological_process,transcription-coupled nucleotide-excision repair","K12867,ko03040,Spliceosome"]
["UBXN4",37.85798482,14.80638807,1.35397852,7.082544467,{"v":5.45E-9,"d":"5.45E-09"},{"v":4.24e-08,"d":"4.24E-08"},"ENSG00000144224","G2HEJ3,UBX domain protein 4","NP_001233439.1,-","PF00789,UBX domain","IPR029071,Ubiquitin-like domain superfamily;IPR001012,UBX domain;IPR036249,Thioredoxin-like superfamily","KOG2507,Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains;ENOG410ZR21,-","GO:0005829,cellular_component,cytosol;GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0005783,cellular_component,endoplasmic reticulum","-"]
["YWHAZ",118.0222721,46.19077905,1.353305875,9.458123959,1.88E-10,{"v":2.02e-09,"d":"2.02E-09"},"ENSG00000164924","E7EX29,14-3-3 protein zeta/delta","-","PF00244,14-3-3 protein","IPR023410,14-3-3 domain;IPR000308,14-3-3 protein;IPR036815,14-3-3 domain superfamily;IPR023409,14-3-3 protein, conserved site","KOG0841,Multifunctional chaperone (14-3-3 family);COG5040,14-3-3 family protein","GO:0019904,molecular_function,protein domain specific binding","-"]
["TCTA",3.371294382,1.312085146,1.353081329,2.844413131,0.012496713,0.023266794,"ENSG00000145022","G1T562,T-cell leukemia translocation-altered gene protein homolog","XP_002713475.1,T-cell leukemia translocation-altered gene protein","PF15128,T-cell leukemia translocation-altered","IPR016560,T-cell leukemia translocation-altered gene protein","-","GO:0045671,biological_process,negative regulation of osteoclast differentiation;GO:0016020,cellular_component,membrane;GO:0072675,biological_process,osteoclast fusion;GO:0016021,cellular_component,integral component of membrane;GO:0005622,cellular_component,intracellular","-"]
["HR",1.054297093,0.410325352,1.353081329,2.844413131,0.012496713,0.023266794,"ENSG00000168453","H2QVU4,Uncharacterized protein","XP_009453248.2,lysine-specific demethylase hairless isoform X4","PF02373,JmjC domain, hydroxylase","IPR003347,JmjC domain","KOG1356,Putative transcription factor 5qNCA, contains JmjC domain;ENOG410XTAA,-","GO:0000785,cellular_component,chromatin;GO:0031490,molecular_function,chromatin DNA binding;GO:0033169,biological_process,histone H3-K9 demethylation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0032454,molecular_function,histone demethylase activity (H3-K9 specific);GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["KIFC2",2.082515329,0.810500989,1.353081329,2.844413131,0.012496713,0.023266794,"ENSG00000167702","H2PRH4,Kinesin-like protein","-","PF00225,Kinesin motor domain","IPR027640,Kinesin-like protein;IPR019821,Kinesin motor domain, conserved site;IPR001752,Kinesin motor domain;IPR036961,Kinesin motor domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG5059,Kinesin-like protein;KOG0239,Kinesin (KAR3 subfamily)","GO:0005874,cellular_component,microtubule;GO:0003774,molecular_function,motor activity;GO:0005524,molecular_function,ATP binding;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity","-"]
["SNX29",2.522147056,0.986064536,1.352189506,4.369187863,{"v":5.92e-05,"d":"5.92E-05"},1.88729E-4,"ENSG00000048471","K7D7Y9,Sorting nexin 29","XP_009428599.1,sorting nexin-29","PF02759,RUN domain;PF00787,PX domain","IPR001683,Phox homologous domain;IPR004012,RUN domain;IPR036871,PX domain superfamily;IPR037916,SNX29, PX domain;IPR037213,RUN domain superfamily","KOG4381,RUN domain-containing protein;ENOG410XRAX,-","GO:0035091,molecular_function,phosphatidylinositol binding","-"]
["NEMP2",4.624664691,1.808907226,1.351672389,4.448155808,{"v":5.52E-5,"d":"5.52E-05"},1.77324E-4,"ENSG00000189362","B7Z482,cDNA FLJ52654","-","PF10225,NEMP family","IPR019358,NEMP family","KOG3817,Uncharacterized conserved protein;ENOG410ZZKM,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-66B24.4",7.516774328,2.942795958,1.351416184,5.186046879,{"v":3.44e-06,"d":"3.44E-06"},{"v":1.45E-5,"d":"1.45E-05"},"ENSG00000259583","H2NY63,Uncharacterized protein","-","-","-","ENOG410KIGR,-;ENOG4110Q8Z,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SLC23A2",4.455340051,1.744050273,1.350792457,4.594144703,{"v":3.42e-05,"d":"3.42E-05"},1.15309E-4,"ENSG00000089057","G7PGW8,Sodium-dependent vitamin C transporter 2","-","PF00860,Permease family","IPR006043,Xanthine/uracil/vitamin C permease;IPR029956,Solute carrier family 23 member 2;IPR006042,Xanthine/uracil permease","-","GO:0022857,molecular_function,transmembrane transporter activity;GO:0070890,molecular_function,sodium-dependent L-ascorbate transmembrane transporter activity;GO:0055085,biological_process,transmembrane transport;GO:0016020,cellular_component,membrane;GO:0015882,biological_process,L-ascorbic acid transmembrane transport;GO:0005215,molecular_function,transporter activity;GO:0016021,cellular_component,integral component of membrane","-"]
["MTMR6",2.177779495,0.850484803,1.350372573,3.252291888,0.002778646,0.006052379,"ENSG00000139505","H2Q7B1,Myotubularin related protein 6","-","PF06602,Myotubularin-like phosphatase domain","IPR029021,Protein-tyrosine phosphatase-like;IPR010569,Myotubularin-like phosphatase domain;IPR030581,Myotubularin-related protein 6;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR016130,Protein-tyrosine phosphatase, active site;IPR030564,Myotubularin family;IPR011993,PH-like domain superfamily","ENOG410XPTU,-;KOG1089,Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6","GO:0046856,biological_process,phosphatidylinositol dephosphorylation;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0106018,molecular_function,phosphatidylinositol-3,5-bisphosphate phosphatase activity;GO:0015269,molecular_function,calcium-activated potassium channel activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0004438,molecular_function,phosphatidylinositol-3-phosphatase activity;GO:0016311,biological_process,dephosphorylation;GO:0052866,molecular_function,phosphatidylinositol phosphate phosphatase activity;GO:0005635,cellular_component,nuclear envelope","-"]
["NT5C3A",3.603031119,1.40708608,1.350372573,3.252291888,0.002778646,0.006052379,"ENSG00000122643","G1RZN2,5'-nucleotidase","-","PF05822,Pyrimidine 5'-nucleotidase (UMPH-1)","IPR006434,Pyrimidine 5'-nucleotidase, eukaryotic;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily","ENOG410ZQJ8,-;KOG3128,Uncharacterized conserved protein","GO:0051607,biological_process,defense response to virus;GO:0016787,molecular_function,hydrolase activity;GO:0008253,molecular_function,5'-nucleotidase activity;GO:0005737,cellular_component,cytoplasm;GO:0005783,cellular_component,endoplasmic reticulum;GO:0009117,biological_process,nucleotide metabolic process;GO:0000287,molecular_function,magnesium ion binding;GO:0016311,biological_process,dephosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005739,cellular_component,mitochondrion","-"]
["GAK",2.538340055,0.994557471,1.349758155,4.788591916,{"v":1.53e-05,"d":"1.53E-05"},{"v":5.59e-05,"d":"5.59E-05"},"ENSG00000178950","H2QP29,Cyclin G associated kinase","-","PF00069,Protein kinase domain;PF10409,C2 domain of PTEN tumour-suppressor protein","IPR014020,Tensin phosphatase, C2 domain;IPR029021,Protein-tyrosine phosphatase-like;IPR001623,DnaJ domain;IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR029023,Tensin-type phosphatase domain;IPR036869,Chaperone J-domain superfamily;IPR000719,Protein kinase domain","KOG2283,Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases;KOG1989,ARK protein kinase family;ENOG410Y515,-;KOG0431,Auxilin-like protein and related proteins containing DnaJ domain","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0006468,biological_process,protein phosphorylation;GO:0031982,cellular_component,vesicle;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding","-"]
["TCHP",12.82505092,5.030397489,1.349557944,6.353084028,{"v":4.88E-8,"d":"4.88E-08"},{"v":3.08e-07,"d":"3.08E-07"},"ENSG00000139437","A0A024RBM9,Trichoplein, keratin filament binding, isoform CRA_a","XP_011537139.1,-;XP_011537138.1,-;NP_115676.1,trichoplein keratin filament-binding protein;NP_001137324.1,-","PF13868,Trichohyalin-plectin-homology domain","IPR026773,Trichoplein keratin filament-binding protein","ENOG410IIAX,-;ENOG410ZEPV,-","GO:0005829,cellular_component,cytosol;GO:0030057,cellular_component,desmosome;GO:0097539,cellular_component,ciliary transition fiber;GO:0045095,cellular_component,keratin filament;GO:0005813,cellular_component,centrosome;GO:0005886,cellular_component,plasma membrane;GO:0005882,cellular_component,intermediate filament","-"]
["POLDIP2",36.60983852,14.36713833,1.34846938,5.780383107,{"v":3.67e-07,"d":"3.67E-07"},{"v":1.89e-06,"d":"1.89E-06"},"ENSG00000004142","G1QNH8,DNA polymerase delta interacting protein 2","-","PF04379,ApaG domain;PF08755,Hemimethylated DNA-binding protein YccV like","-","-","-","-"]
["PLCE1",1.359013979,0.532168008,1.348231037,3.704345598,0.00096388,0.00233224,"ENSG00000138193","B7ZM61,Phosphoinositide phospholipase C","NP_001275918.1,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 3","PF00617,RasGEF domain;PF00388,Phosphatidylinositol-specific phospholipase C, X domain;PF00788,Ras association (RalGDS/AF-6) domain;PF09279,Phosphoinositide-specific phospholipase C, efhand-like;PF00387,Phosphatidylinositol-specific phospholipase C, Y domain;PF00168,C2 domain","IPR000909,Phosphatidylinositol-specific phospholipase C, X domain;IPR001192,Phosphoinositide phospholipase C family;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily;IPR001895,Ras guanine-nucleotide exchange factors catalytic domain;IPR000159,Ras-associating (RA) domain;IPR028398,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;IPR023578,Ras guanine nucleotide exchange factor domain superfamily;IPR035892,C2 domain superfamily;IPR011992,EF-hand domain pair;IPR029071,Ubiquitin-like domain superfamily;IPR001711,Phospholipase C, phosphatidylinositol-specific, Y domain;IPR015359,Phosphoinositide-specific phospholipase C, EF-hand-like domain;IPR000008,C2 domain","KOG0169,Phosphoinositide-specific phospholipase C;ENOG410XPSW,-","GO:0006629,biological_process,lipid metabolic process;GO:0004435,molecular_function,phosphatidylinositol phospholipase C activity;GO:0016787,molecular_function,hydrolase activity;GO:0035556,biological_process,intracellular signal transduction;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0004871,molecular_function,signal transducer activity;GO:0065009,biological_process,regulation of molecular function;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0005622,cellular_component,intracellular;GO:0016042,biological_process,lipid catabolic process;GO:0007165,biological_process,signal transduction","-"]
["RNF135",5.372701611,2.105100345,1.347763935,3.827994663,0.000535268,1.378858E-3,"ENSG00000181481","H2QCL9,Ring finger protein 135","XP_001174802.1,E3 ubiquitin-protein ligase RNF135 isoform X1","PF15227,zinc finger of C3HC4-type, RING;PF00622,SPRY domain","IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR003877,SPRY domain;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR006574,SPRY-associated","ENOG4111G04,-;KOG2177,Predicted E3 ubiquitin ligase","GO:0032728,biological_process,positive regulation of interferon-beta production;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0046872,molecular_function,metal ion binding;GO:0045088,biological_process,regulation of innate immune response;GO:0042802,molecular_function,identical protein binding;GO:0043021,molecular_function,ribonucleoprotein complex binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity","-"]
["UBR2",6.608053817,2.59462004,1.347388584,5.377310963,{"v":1.54e-06,"d":"1.54E-06"},{"v":7.03e-06,"d":"7.03E-06"},"ENSG00000024048","K7ADR9,Ubiquitin protein ligase E3 component n-recognin 2","XP_016811008.1,-;XP_016810992.1,E3 ubiquitin-protein ligase UBR2 isoform X1","PF02207,Putative zinc finger in N-recognin (UBR box);PF02617,ATP-dependent Clp protease adaptor protein ClpS","IPR003769,Adaptor protein ClpS, core;IPR036390,Winged helix DNA-binding domain superfamily;IPR014719,Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like;IPR003126,Zinc finger, UBR-type","KOG1140,N-end rule pathway, recognition component UBR1;ENOG410XPQU,-","GO:0030163,biological_process,protein catabolic process;GO:0016874,molecular_function,ligase activity;GO:0008270,molecular_function,zinc ion binding","-"]
["FAM166A",12.52566008,4.912222664,1.347036225,4.047215292,0.000269375,0.00074161,"ENSG00000188163","H2R0T3,Uncharacterized protein","XP_016817748.1,protein FAM166A isoform X7","PF10629,Protein of unknown function (DUF2475)","IPR018902,Uncharacterised protein family UPF0573/UPF0605","ENOG410YQTM,-;ENOG410IED4,-","-","-"]
["DAP",18.86398655,7.409229939,1.347029368,5.493305386,{"v":9.62e-07,"d":"9.62E-07"},{"v":4.55e-06,"d":"4.55E-06"},"ENSG00000112977","B4DQ75,Death-associated protein 1","NP_001278892.1,death-associated protein 1 isoform 1","PF15228,eath-associated protein","IPR024130,DAP1/DAPL1","ENOG41122SE,-;ENOG410IZ5N,-","-","-"]
["ANAPC2",4.446655924,1.744490528,1.346747278,4.145401773,0.000161425,4.66813E-4,"ENSG00000176248","K7CRJ8,Anaphase promoting complex subunit 2","-","PF08672,Anaphase promoting complex (APC) subunit 2;PF00888,Cullin family","-","-","-","-"]
["ZKSCAN8",3.421435008,1.342705459,1.34649544,4.237289751,1.45525E-4,0.000426039,"ENSG00000198315","A0A024RCK7,Zinc finger protein 192, isoform CRA_a","NP_001265048.1,-;XP_016866755.1,-;XP_011513172.1,-;NP_006289.2,zinc finger protein with KRAB and SCAN domains 8 isoform 1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF02023,SCAN domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR003309,SCAN domain;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR038269,SCAN domain superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","-"]
["ZBTB41",3.605444859,1.41597144,1.345902646,4.48216017,{"v":5.4e-05,"d":"5.40E-05"},0.000173758,"ENSG00000177888","G3QQ84,Zinc finger and BTB domain containing 41","XP_004028143.1,zinc finger and BTB domain-containing protein 41","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["LIMCH1",15.56542289,6.123704599,1.345415489,6.891372564,{"v":1.08e-08,"d":"1.08E-08"},{"v":7.94e-08,"d":"7.94E-08"},"ENSG00000064042","G5EA03,LIM and calponin homology domains-containing protein 1","NP_001317601.1,LIM and calponin homology domains-containing protein 1 isoform h","PF15949,omain of unknown function (DUF4757);PF00412,LIM domain","IPR031865,Domain of unknown function DUF4757;IPR029980,LIM and calponin homology domains-containing protein 1;IPR001781,Zinc finger, LIM-type","ENOG410INGA,-;ENOG410XQB9,-","GO:0046872,molecular_function,metal ion binding","-"]
["ZC3H7A",6.476795935,2.546847015,1.344898249,5.035733709,{"v":5.42e-06,"d":"5.42E-06"},{"v":2.19E-5,"d":"2.19E-05"},"ENSG00000122299","G1RGS2,Zinc finger CCCH-type containing 7A","XP_012352846.1,zinc finger CCCH domain-containing protein 7A;XP_012352847.1,-","PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)","IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type;IPR036236,Zinc finger C2H2 superfamily;IPR011990,Tetratricopeptide-like helical domain superfamily","ENOG41100XQ,-;ENOG410IDY2,-","GO:0010608,biological_process,posttranscriptional regulation of gene expression;GO:0035198,molecular_function,miRNA binding;GO:0035196,biological_process,production of miRNAs involved in gene silencing by miRNA;GO:0046872,molecular_function,metal ion binding","-"]
["SAMD1",26.86248219,10.56978855,1.344388192,5.434474103,{"v":1.38e-06,"d":"1.38E-06"},{"v":6.37E-6,"d":"6.37E-06"},"ENSG00000141858","E9PIW9,Atherin","-","PF00536,SAM domain (Sterile alpha motif)","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain","ENOG410IX26,-;ENOG4111QIZ,-","-","-"]
["BBX",12.11592557,4.772735202,1.343485706,6.661236784,{"v":2.31e-08,"d":"2.31E-08"},{"v":1.57e-07,"d":"1.57E-07"},"ENSG00000114439","A8K6U2,cDNA FLJ78675, highly similar to Homo sapiens stroma HMG-box containing protein","NP_001136040.1,HMG box transcription factor BBX isoform 1","PF09667,omain of unknown function (DUF2028);PF00505,HMG (high mobility group) box","IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily;IPR019102,HMG box transcription factor BBX, domain of unknown function DUF2028","ENOG410Y941,-;ENOG410ITBH,-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["RB1CC1",21.26694932,8.3905938,1.341297896,6.83088644,{"v":1.52E-8,"d":"1.52E-08"},{"v":1.08E-7,"d":"1.08E-07"},"ENSG00000023287","H2QW57,RB1-inducible coiled-coil 1","XP_009453658.1,-;XP_001149383.2,RB1-inducible coiled-coil protein 1 isoform X1","PF10377,Autophagy-related protein 11","IPR019460,Autophagy-related protein 11","ENOG410XSY4,-;KOG4572,Predicted DNA-binding transcription factor, interacts with stathmin","GO:0000422,biological_process,autophagy of mitochondrion;GO:0034045,cellular_component,phagophore assembly site membrane;GO:0019901,molecular_function,protein kinase binding;GO:0000407,cellular_component,phagophore assembly site;GO:0007507,biological_process,heart development;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0045793,biological_process,positive regulation of cell size;GO:0001889,biological_process,liver development;GO:0006914,biological_process,autophagy;GO:0030242,biological_process,autophagy of peroxisome;GO:0005634,cellular_component,nucleus;GO:0061709,biological_process,reticulophagy;GO:0061723,biological_process,glycophagy;GO:2001237,biological_process,negative regulation of extrinsic apoptotic signaling pathway;GO:1990316,cellular_component,Atg1/ULK1 kinase complex;GO:0000045,biological_process,autophagosome assembly;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol;GO:0032947,molecular_function,protein-containing complex scaffold activity;GO:0046330,biological_process,positive regulation of JNK cascade;GO:0001934,biological_process,positive regulation of protein phosphorylation","K17589,ko04211,Longevity regulating pathway"]
["FBXO38",4.573871177,1.803238404,1.340915937,4.841910078,{"v":1.27E-5,"d":"1.27E-05"},{"v":4.71E-5,"d":"4.71E-05"},"ENSG00000145868","H2QRR2,F-box protein 38","XP_001161504.2,F-box only protein 38 isoform X1","PF00646,-box domain","IPR036047,F-box-like domain superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR001810,F-box domain","ENOG410IFU5,-;ENOG410XS1U,-","GO:0005737,cellular_component,cytoplasm;GO:0010976,biological_process,positive regulation of neuron projection development;GO:0005634,cellular_component,nucleus","-"]
["PRELID1",116.0071963,45.78550539,1.340901404,7.253672104,{"v":5.41e-09,"d":"5.41E-09"},{"v":4.21E-8,"d":"4.21E-08"},"ENSG00000169230","B5XEN4,PRELI domain-containing protein 1, mitochondrial","-","PF04707,PRELI-like family","IPR037365,Slowmo/Ups family;IPR006797,PRELI/MSF1 domain","-","GO:0005758,cellular_component,mitochondrial intermembrane space","-"]
["CNST",5.333029268,2.102534771,1.340414364,4.515380118,{"v":4.37e-05,"d":"4.37E-05"},1.43938E-4,"ENSG00000162852","A0A024R5U9,Chromosome 1 open reading frame 71, isoform CRA_d","-","PF15281,Consortin C-terminus","IPR028129,Consortin, C-terminal domain","ENOG411023R,-;ENOG410IHAY,-","GO:0005802,cellular_component,trans-Golgi network;GO:0071253,molecular_function,connexin binding;GO:0042998,biological_process,positive regulation of Golgi to plasma membrane protein transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NFU1",11.34880075,4.474239123,1.339772937,4.187269063,0.000185617,0.000531235,"ENSG00000169599","H2QI15,NFU1 iron-sulfur cluster scaffold homolog","XP_016804161.1,-","PF01106,NifU-like domain;PF08712,Scaffold protein Nfu/NifU N terminal","IPR001075,NIF system FeS cluster assembly, NifU, C-terminal;IPR035433,NFU1-like;IPR014824,Scaffold protein Nfu/NifU, N-terminal;IPR036498,Scaffold protein Nfu/NifU, N-terminal domain superfamily;IPR034904,Fe-S cluster assembly domain superfamily","KOG2358,NifU-like domain-containing proteins;COG0694,Thioredoxin-like proteins and domains","GO:0016226,biological_process,iron-sulfur cluster assembly;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0005506,molecular_function,iron ion binding","-"]
["ADGRG1",8.144781516,3.216467587,1.339320926,5.646292874,{"v":6.51e-07,"d":"6.51E-07"},{"v":3.2e-06,"d":"3.20E-06"},"ENSG00000205336","A0A024R6U7,G protein-coupled receptor 56 isoform 1","XP_011521767.1,-;XP_011521766.1,-;XP_005256311.1,-;XP_011521770.1,-;XP_005256308.1,-;XP_005256303.1,-;NP_001139243.1,-;XP_011521765.1,-;XP_005256306.1,-;XP_006721409.1,-;XP_011521768.1,-;XP_006721405.1,-;XP_006721408.1,-;XP_005256309.1,-;XP_011521769.1,-;XP_005256305.1,-;XP_005256304.1,-;XP_006721406.1,-;NP_005673.3,adhesion G-protein coupled receptor G1 isoform a precursor;XP_006721407.1,-","PF00002,7 transmembrane receptor (Secretin family);PF01825,PCR proteolysis site, GPS, motif","IPR000832,GPCR, family 2, secretin-like;IPR000203,GPS motif;IPR017981,GPCR, family 2-like;IPR003910,GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5","ENOG410XSD2,-;KOG4193,G protein-coupled receptors","GO:0097451,cellular_component,glial limiting end-foot;GO:0004888,molecular_function,transmembrane signaling receptor activity;GO:2000179,biological_process,positive regulation of neural precursor cell proliferation;GO:0021801,biological_process,cerebral cortex radial glia guided migration;GO:0016020,cellular_component,membrane;GO:0005518,molecular_function,collagen binding;GO:0072520,biological_process,seminiferous tubule development;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0021819,biological_process,layer formation in cerebral cortex;GO:0008201,molecular_function,heparin binding;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0021796,biological_process,cerebral cortex regionalization;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0035025,biological_process,positive regulation of Rho protein signal transduction;GO:2001223,biological_process,negative regulation of neuron migration;GO:0016021,cellular_component,integral component of membrane;GO:0050840,molecular_function,extracellular matrix binding","-"]
["NEMP1",3.494508095,1.377701941,1.339012095,3.880044959,0.000403177,0.001067687,"ENSG00000166881","H2Q6A2,Transmembrane protein 194A","XP_009423360.1,-","PF10225,NEMP family","IPR019358,NEMP family","KOG3817,Uncharacterized conserved protein;ENOG410ZZKM,-","GO:0005635,cellular_component,nuclear envelope;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CAV1",66.20030508,26.16812423,1.338746294,7.565690352,{"v":2.94e-09,"d":"2.94E-09"},{"v":2.43e-08,"d":"2.43E-08"},"ENSG00000105974","I7GJT1,Caveolin","NP_001271690.1,-;XP_015302748.1,-","PF01146,Caveolin","IPR001612,Caveolin;IPR018361,Caveolin, conserved site;IPR015504,Caveolin-1","-","GO:0031397,biological_process,negative regulation of protein ubiquitination;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:2000286,biological_process,receptor internalization involved in canonical Wnt signaling pathway;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001960,biological_process,negative regulation of cytokine-mediated signaling pathway;GO:0019901,molecular_function,protein kinase binding;GO:0001666,biological_process,response to hypoxia;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005938,cellular_component,cell cortex;GO:0070320,molecular_function,inward rectifier potassium channel inhibitor activity;GO:0051117,molecular_function,ATPase binding;GO:0006816,biological_process,calcium ion transport;GO:1901380,biological_process,negative regulation of potassium ion transmembrane transport;GO:0009968,biological_process,negative regulation of signal transduction;GO:0045907,biological_process,positive regulation of vasoconstriction;GO:0005768,cellular_component,endosome;GO:0055074,biological_process,calcium ion homeostasis;GO:0098911,biological_process,regulation of ventricular cardiac muscle cell action potential;GO:0002931,biological_process,response to ischemia;GO:0019899,molecular_function,enzyme binding;GO:0051260,biological_process,protein homooligomerization;GO:0042802,molecular_function,identical protein binding;GO:0044325,molecular_function,ion channel binding;GO:0006940,biological_process,regulation of smooth muscle contraction;GO:0048365,molecular_function,Rac GTPase binding;GO:1903609,biological_process,negative regulation of inward rectifier potassium channel activity;GO:0005886,cellular_component,plasma membrane;GO:0001937,biological_process,negative regulation of endothelial cell proliferation;GO:0032991,cellular_component,protein-containing complex;GO:0009617,biological_process,response to bacterium;GO:0005102,molecular_function,signaling receptor binding;GO:0005783,cellular_component,endoplasmic reticulum;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:2000811,biological_process,negative regulation of anoikis;GO:1903598,biological_process,positive regulation of gap junction assembly;GO:0071455,biological_process,cellular response to hyperoxia;GO:0034141,biological_process,positive regulation of toll-like receptor 3 signaling pathway;GO:0000188,biological_process,inactivation of MAPK activity;GO:0051480,biological_process,regulation of cytosolic calcium ion concentration;GO:0030879,biological_process,mammary gland development;GO:0060355,biological_process,positive regulation of cell adhesion molecule production;GO:0010628,biological_process,positive regulation of gene expression;GO:0006874,biological_process,cellular calcium ion homeostasis;GO:0019217,biological_process,regulation of fatty acid metabolic process;GO:0008104,biological_process,protein localization;GO:0005794,cellular_component,Golgi apparatus;GO:0000139,cellular_component,Golgi membrane;GO:2001244,biological_process,positive regulation of intrinsic apoptotic signaling pathway;GO:0042532,biological_process,negative regulation of tyrosine phosphorylation of STAT protein;GO:0097190,biological_process,apoptotic signaling pathway;GO:0031295,biological_process,T cell costimulation;GO:0031410,cellular_component,cytoplasmic vesicle;GO:2000535,biological_process,regulation of entry of bacterium into host cell;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0043409,biological_process,negative regulation of MAPK cascade;GO:0032091,biological_process,negative regulation of protein binding;GO:0007519,biological_process,skeletal muscle tissue development;GO:0031398,biological_process,positive regulation of protein ubiquitination;GO:0005622,cellular_component,intracellular;GO:0033484,biological_process,nitric oxide homeostasis;GO:0006641,biological_process,triglyceride metabolic process;GO:0042632,biological_process,cholesterol homeostasis;GO:0070836,biological_process,caveola assembly;GO:0003057,biological_process,regulation of the force of heart contraction by chemical signal;GO:0033137,biological_process,negative regulation of peptidyl-serine phosphorylation;GO:0030857,biological_process,negative regulation of epithelial cell differentiation;GO:0051592,biological_process,response to calcium ion;GO:0010524,biological_process,positive regulation of calcium ion transport into cytosol;GO:0005198,molecular_function,structural molecule activity;GO:0032947,molecular_function,protein-containing complex scaffold activity;GO:0005925,cellular_component,focal adhesion;GO:0010952,biological_process,positive regulation of peptidase activity;GO:0002080,cellular_component,acrosomal membrane;GO:0002026,biological_process,regulation of the force of heart contraction;GO:0034098,cellular_component,VCP-NPL4-UFD1 AAA ATPase complex;GO:0001570,biological_process,vasculogenesis;GO:2001238,biological_process,positive regulation of extrinsic apoptotic signaling pathway;GO:0030193,biological_process,regulation of blood coagulation;GO:0071375,biological_process,cellular response to peptide hormone stimulus;GO:0010608,biological_process,posttranscriptional regulation of gene expression;GO:0051259,biological_process,protein complex oligomerization;GO:0016021,cellular_component,integral component of membrane;GO:0043627,biological_process,response to estrogen;GO:0043085,biological_process,positive regulation of catalytic activity;GO:0045019,biological_process,negative regulation of nitric oxide biosynthetic process;GO:0060546,biological_process,negative regulation of necroptotic process;GO:0016504,molecular_function,peptidase activator activity;GO:0005901,cellular_component,caveola;GO:0032092,biological_process,positive regulation of protein binding;GO:0045121,cellular_component,membrane raft;GO:1900085,biological_process,negative regulation of peptidyl-tyrosine autophosphorylation;GO:0019065,biological_process,receptor-mediated endocytosis of virus by host cell;GO:0052547,biological_process,regulation of peptidase activity;GO:0005929,cellular_component,cilium;GO:1900027,biological_process,regulation of ruffle assembly;GO:0086091,biological_process,regulation of heart rate by cardiac conduction;GO:0043407,biological_process,negative regulation of MAP kinase activity;GO:0030674,molecular_function,protein binding, bridging;GO:0061099,biological_process,negative regulation of protein tyrosine kinase activity;GO:0042310,biological_process,vasoconstriction;GO:0051001,biological_process,negative regulation of nitric-oxide synthase activity;GO:0007595,biological_process,lactation;GO:0072584,biological_process,caveolin-mediated endocytosis;GO:0031623,biological_process,receptor internalization;GO:0071360,biological_process,cellular response to exogenous dsRNA;GO:0048550,biological_process,negative regulation of pinocytosis;GO:1901844,biological_process,regulation of cell communication by electrical coupling involved in cardiac conduction;GO:0030512,biological_process,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0005887,cellular_component,integral component of plasma membrane;GO:0051899,biological_process,membrane depolarization;GO:0086098,biological_process,angiotensin-activated signaling pathway involved in heart process;GO:0001525,biological_process,angiogenesis;GO:0016020,cellular_component,membrane;GO:0060056,biological_process,mammary gland involution;GO:0098903,biological_process,regulation of membrane repolarization during action potential;GO:0019915,biological_process,lipid storage;GO:0032570,biological_process,response to progesterone;GO:0050998,molecular_function,nitric-oxide synthase binding;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0071560,biological_process,cellular response to transforming growth factor beta stimulus;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway;GO:0046426,biological_process,negative regulation of JAK-STAT cascade","K06278,ko04510,Focal adhesion;K06278,ko05416,Viral myocarditis;K06278,ko04144,Endocytosis;K06278,ko05205,Proteoglycans in cancer;K06278,ko05100,Bacterial invasion of epithelial cells"]
["PURB",9.504689904,3.757525448,1.337976166,5.931698465,{"v":2.81e-07,"d":"2.81E-07"},{"v":1.49e-06,"d":"1.49E-06"},"ENSG00000146676","I2CY42,Purine rich element binding protein B","XP_002803334.2,-","PF04845,PurA ssDNA and RNA-binding protein","IPR006628,Purine-rich element binding protein family;IPR030499,Purine-rich element-binding protein beta","-","GO:0003697,molecular_function,single-stranded DNA binding;GO:0046332,molecular_function,SMAD binding;GO:0003677,molecular_function,DNA binding;GO:0008283,biological_process,cell proliferation;GO:0030154,biological_process,cell differentiation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0003690,molecular_function,double-stranded DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003723,molecular_function,RNA binding;GO:0005662,cellular_component,DNA replication factor A complex;GO:0008134,molecular_function,transcription factor binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0003729,molecular_function,mRNA binding","-"]
["FAM13B",6.452721339,2.550846444,1.337204972,4.978247753,{"v":8.74e-06,"d":"8.74E-06"},{"v":3.37e-05,"d":"3.37E-05"},"ENSG00000031003","B2RAJ9,cDNA, FLJ94962","-","PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain","ENOG410XRR2,-;KOG4270,GTPase-activator protein","GO:0007165,biological_process,signal transduction","-"]
["GOPC",9.492248677,3.752411968,1.337204972,4.978247753,{"v":8.74e-06,"d":"8.74E-06"},{"v":3.37e-05,"d":"3.37E-05"},"ENSG00000047932","H2QTM9,Golgi-associated PDZ and coiled-coil motif containing","XP_518712.2,Golgi-associated PDZ and coiled-coil motif-containing protein isoform X1","PF00595,PDZ domain (Also known as DHR or GLGF)","IPR036034,PDZ superfamily;IPR001478,PDZ domain","ENOG410XT8J,-;ENOG410ITAF,-","GO:0030695,molecular_function,GTPase regulator activity;GO:0005794,cellular_component,Golgi apparatus;GO:0030140,cellular_component,trans-Golgi network transport vesicle;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0044325,molecular_function,ion channel binding;GO:0007289,biological_process,spermatid nucleus differentiation;GO:0051260,biological_process,protein homooligomerization;GO:0005109,molecular_function,frizzled binding;GO:0050790,biological_process,regulation of catalytic activity;GO:0005886,cellular_component,plasma membrane;GO:0008022,molecular_function,protein C-terminus binding;GO:0010360,biological_process,negative regulation of anion channel activity;GO:0016020,cellular_component,membrane;GO:0045202,cellular_component,synapse;GO:2000009,biological_process,negative regulation of protein localization to cell surface;GO:0043004,biological_process,cytoplasmic sequestering of CFTR protein","-"]
["SEL1L",10.48312389,4.147638545,1.336950127,6.146400326,{"v":1.28e-07,"d":"1.28E-07"},{"v":7.3E-7,"d":"7.30E-07"},"ENSG00000071537","H2Q8Q7,Sel-1 suppressor of lin-12-like","XP_510102.3,protein sel-1 homolog 1 isoform X1","PF08238,Sel1 repeat;PF00040,ibronectin type II domain","IPR036943,Fibronectin type II domain superfamily;IPR000562,Fibronectin type II domain;IPR006597,Sel1-like repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR013806,Kringle-like fold","KOG1550,Extracellular protein SEL-1 and related proteins;COG0790,FOG: TPR repeat, SEL1 subfamily","GO:0036503,biological_process,ERAD pathway;GO:0036513,cellular_component,Derlin-1 retrotranslocation complex;GO:0009306,biological_process,protein secretion;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0000839,cellular_component,Hrd1p ubiquitin ligase ERAD-L complex;GO:0005783,cellular_component,endoplasmic reticulum;GO:0030970,biological_process,retrograde protein transport, ER to cytosol;GO:0016020,cellular_component,membrane;GO:0006641,biological_process,triglyceride metabolic process;GO:0016021,cellular_component,integral component of membrane","-"]
["SKP2",10.5826648,4.184391141,1.336746162,4.867847429,{"v":1.26E-5,"d":"1.26E-05"},{"v":4.67e-05,"d":"4.67E-05"},"ENSG00000145604","A0A0A0MTL5,S-phase kinase-associated protein 2","-","PF12937,-box-like","IPR006553,Leucine-rich repeat, cysteine-containing subtype;IPR036047,F-box-like domain superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR001810,F-box domain","ENOG410Z2W2,-;KOG2120,SCF ubiquitin ligase, Skp2 component","GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus","-"]
["GOLPH3L",27.60500938,10.92539574,1.336420131,6.023228351,{"v":1.9e-07,"d":"1.90E-07"},{"v":1.05e-06,"d":"1.05E-06"},"ENSG00000143457","H2R8P1,Golgi phosphoprotein 3-like","XP_001169746.1,-","PF05719,olgi phosphoprotein 3 (GPP34)","IPR008628,Golgi phosphoprotein 3-like;IPR038261,Golgi phosphoprotein 3-like domain superfamily","ENOG410XRT6,-;KOG3983,Golgi protein","GO:0031985,cellular_component,Golgi cisterna;GO:0070273,molecular_function,phosphatidylinositol-4-phosphate binding;GO:0050714,biological_process,positive regulation of protein secretion;GO:0005802,cellular_component,trans-Golgi network;GO:0000139,cellular_component,Golgi membrane;GO:0007030,biological_process,Golgi organization;GO:0006890,biological_process,retrograde vesicle-mediated transport, Golgi to ER;GO:0005829,cellular_component,cytosol;GO:0048194,biological_process,Golgi vesicle budding;GO:0043001,biological_process,Golgi to plasma membrane protein transport","K15620,ko05202,Transcriptional misregulation in cancer"]
["MRPS36",7.604932757,2.998227602,1.33630234,3.150702965,5.263785E-3,0.010730946,"ENSG00000134056","H2QR07,Mitochondrial ribosomal protein S36","XP_001145508.1,-","-","-","ENOG410XTRG,-;ENOG410IZ0U,-","GO:0009353,cellular_component,mitochondrial oxoglutarate dehydrogenase complex;GO:0005840,cellular_component,ribosome;GO:0005739,cellular_component,mitochondrion;GO:0005763,cellular_component,mitochondrial small ribosomal subunit","-"]
["DCUN1D1",16.23152443,6.427064722,1.336012035,6.58823186,{"v":2.99e-08,"d":"2.99E-08"},{"v":1.98E-7,"d":"1.98E-07"},"ENSG00000043093","A0A1S3GKH6,DCN1-like protein","XP_012888513.1,-;XP_012888512.1,-","-","IPR005176,Potentiating neddylation domain;IPR009060,UBA-like superfamily;IPR014764,Defective-in-cullin neddylation protein","-","-","-"]
["MAP2K7",10.93839736,4.330634454,1.335406185,5.32786456,{"v":2.29e-06,"d":"2.29E-06"},{"v":1.01E-5,"d":"1.01E-05"},"ENSG00000076984","H2RBC8,Uncharacterized protein","XP_009432815.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG0983,Mitogen-activated protein kinase (MAPK) kinase MKK7/JNKK2;ENOG410XTNQ,-","GO:0007346,biological_process,regulation of mitotic cell cycle;GO:0031098,biological_process,stress-activated protein kinase signaling cascade;GO:0023014,biological_process,signal transduction by protein phosphorylation;GO:0042981,biological_process,regulation of apoptotic process;GO:0032147,biological_process,activation of protein kinase activity;GO:0005737,cellular_component,cytoplasm;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["NBPF10",0.750438382,0.295858641,1.335221722,2.946231413,0.011232888,0.021098374,"ENSG00000271425","A0A075B762,Neuroblastoma breakpoint family member 10","NP_001289300.1,neuroblastoma breakpoint family member 10 isoform a","PF06758,Repeat of unknown function (DUF1220)","IPR010630,Neuroblastoma breakpoint family (NBPF) domain","-","-","-"]
["NSMCE3",2.061456408,0.812724543,1.335221722,2.946231413,0.011232888,0.021098374,"ENSG00000185115","K7AY23,Necdin-like 2","XP_009426973.1,non-structural maintenance of chromosomes element 3 homolog","PF01454,MAGE family","IPR037445,Melanoma-associated antigen;IPR002190,MAGE homology domain","-","-","-"]
["RFK",2.572433867,1.014176255,1.335221722,2.946231413,0.011232888,0.021098374,"ENSG00000135002","K7BEG2,Riboflavin kinase","XP_016816462.1,-","PF01687,Riboflavin kinase","IPR023465,Riboflavin kinase domain superfamily;IPR015865,Riboflavin kinase domain, bacterial/eukaryotic;IPR023468,Riboflavin kinase","KOG3110,Riboflavin kinase;COG0196,FAD synthase","GO:0016301,molecular_function,kinase activity;GO:0009231,biological_process,riboflavin biosynthetic process;GO:0006915,biological_process,apoptotic process;GO:0008531,molecular_function,riboflavin kinase activity;GO:0033864,biological_process,positive regulation of NAD(P)H oxidase activity;GO:0016310,biological_process,phosphorylation","K00861,ko00740,Riboflavin metabolism"]
["TSC2",8.327439678,3.299910606,1.334629656,6.034714338,{"v":1.92E-7,"d":"1.92E-07"},{"v":1.06E-6,"d":"1.06E-06"},"ENSG00000103197","A0A1V1FWL6,Tuberin","-","-","IPR003913,Tuberin;IPR024584,Tuberin, N-terminal;IPR035974,Rap/Ran-GAP superfamily;IPR016024,Armadillo-type fold;IPR027107,Tuberin/Ral GTPase-activating protein subunit alpha;IPR018515,Tuberin-type domain;IPR000331,Rap GTPase activating protein domain","-","GO:0033596,cellular_component,TSC1-TSC2 complex;GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0032007,biological_process,negative regulation of TOR signaling;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0005634,cellular_component,nucleus","-"]
["PGK1",19.07574574,7.563791438,1.333826722,6.190506233,{"v":1.03E-7,"d":"1.03E-07"},{"v":6.03e-07,"d":"6.03E-07"},"ENSG00000102144","K7CCI1,Phosphoglycerate kinase","NP_001129210.1,-","PF00162,Phosphoglycerate kinase","IPR001576,Phosphoglycerate kinase;IPR015824,Phosphoglycerate kinase, N-terminal;IPR015911,Phosphoglycerate kinase, conserved site;IPR036043,Phosphoglycerate kinase superfamily","KOG1367,3-phosphoglycerate kinase;COG0126,3-phosphoglycerate kinase","GO:0016301,molecular_function,kinase activity;GO:0006096,biological_process,glycolytic process;GO:0004618,molecular_function,phosphoglycerate kinase activity;GO:0016310,biological_process,phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding","K00927,ko00010,Glycolysis / Gluconeogenesis;K00927,ko01200,Carbon metabolism;K00927,ko00710,Carbon fixation in photosynthetic organisms;K00927,ko01230,Biosynthesis of amino acids"]
["NCBP1",8.346201934,3.307345516,1.333814325,5.053204429,{"v":7.32e-06,"d":"7.32E-06"},{"v":2.87E-5,"d":"2.87E-05"},"ENSG00000136937","H2PSU5,Nuclear cap binding protein subunit 1","XP_002820061.1,-","PF09090,MIF4G like;PF09088,MIF4G like;PF02854,MIF4G domain","IPR016021,MIF4G-like domain superfamily;IPR003890,MIF4G-like, type 3;IPR027159,Nuclear cap-binding protein subunit 1;IPR015174,MIF4G-like, type 2;IPR016024,Armadillo-type fold;IPR015172,MIF4G-like, type 1","KOG1104,Nuclear cap-binding complex, subunit NCBP1/CBP80;ENOG410XR7H,-","GO:0048026,biological_process,positive regulation of mRNA splicing, via spliceosome;GO:0006446,biological_process,regulation of translational initiation;GO:0000340,molecular_function,RNA 7-methylguanosine cap binding;GO:0005634,cellular_component,nucleus;GO:0005845,cellular_component,mRNA cap binding complex;GO:0016070,biological_process,RNA metabolic process;GO:0005846,cellular_component,nuclear cap binding complex;GO:0005739,cellular_component,mitochondrion;GO:0000245,biological_process,spliceosomal complex assembly;GO:0030307,biological_process,positive regulation of cell growth;GO:0000339,molecular_function,RNA cap binding;GO:0051028,biological_process,mRNA transport;GO:0034518,cellular_component,RNA cap binding complex;GO:0005654,cellular_component,nucleoplasm;GO:0005829,cellular_component,cytosol;GO:0045292,biological_process,mRNA cis splicing, via spliceosome;GO:0006370,biological_process,7-methylguanosine mRNA capping;GO:0031442,biological_process,positive regulation of mRNA 3'-end processing;GO:0003723,molecular_function,RNA binding;GO:0000184,biological_process,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:1905216,biological_process,positive regulation of RNA binding;GO:0006406,biological_process,mRNA export from nucleus;GO:0030529,,;GO:0098789,biological_process,pre-mRNA cleavage required for polyadenylation","K12882,ko03013,RNA transport;K12882,ko03015,mRNA surveillance pathway;K12882,ko03040,Spliceosome"]
["SYT14",0.596804903,0.235288988,1.333711996,2.707298824,0.015563707,0.028310923,"ENSG00000143469","A0A1B0GTZ1,Synaptotagmin-14","XP_006711325.1,synaptotagmin-14 isoform X1","PF00168,C2 domain","IPR028696,Synaptotagmin-14;IPR000008,C2 domain;IPR035892,C2 domain superfamily","-","-","-"]
["GCNT2",0.918151247,0.36197906,1.333711996,2.707298824,0.015563707,0.028310923,"ENSG00000111846","Q08M29,Beta-1,6-N-acetylglucosaminyltransferase 2","-","PF02485,Core-2/I-Branching enzyme","IPR003406,Glycosyl transferase, family 14","-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0008375,molecular_function,acetylglucosaminyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane","-"]
["IRAK1BP1",1.101976277,0.434451664,1.333711996,2.707298824,0.015563707,0.028310923,"ENSG00000146243","H2QTA8,Interleukin-1 receptor-associated kinase 1-binding protein 1","XP_016811376.1,interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X1","PF04402,Protein of unknown function (DUF541)","IPR007497,Protein of unknown function DUF541;IPR030312,Interleukin-1 receptor-associated kinase 1-binding protein 1","ENOG4111TM2,-;ENOG410II1K,-","GO:0006955,biological_process,immune response;GO:0007249,biological_process,I-kappaB kinase/NF-kappaB signaling;GO:0005622,cellular_component,intracellular","-"]
["MFSD14C",2.382770953,0.939402079,1.333711996,2.707298824,0.015563707,0.028310923,"ENSG00000196312","R4GN14,Hippocampus abundant transcript-like protein 2","-","-","IPR036259,MFS transporter superfamily;IPR011701,Major facilitator superfamily;IPR020846,Major facilitator superfamily domain;IPR005829,Sugar transporter, conserved site","ENOG410ZVCA,-;KOG2816,Predicted transporter ADD1 (major facilitator superfamily)","GO:0055085,biological_process,transmembrane transport;GO:0005215,molecular_function,transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GFM1",4.94270453,1.959015283,1.333480141,5.001861481,{"v":7.43E-6,"d":"7.43E-06"},{"v":2.91e-05,"d":"2.91E-05"},"ENSG00000168827","G3S1S5,Elongation factor G, mitochondrial","XP_018879806.1,elongation factor G, mitochondrial isoform X1","PF00009,longation factor Tu GTP binding domain;PF00679,longation factor G C-terminus;PF03144,longation factor Tu domain 2;PF14492,longation Factor G, domain II;PF03764,longation factor G, domain IV","IPR035647,EF-G domain III/V-like;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004161,Translation elongation factor EFTu-like, domain 2;IPR005517,Translation elongation factor EFG/EF2, domain IV;IPR000795,Transcription factor, GTP-binding domain;IPR009000,Translation protein, beta-barrel domain superfamily;IPR020568,Ribosomal protein S5 domain 2-type fold;IPR031157,Tr-type G domain, conserved site;IPR014721,Ribosomal protein S5 domain 2-type fold, subgroup;IPR004540,Translation elongation factor EFG/EF2;IPR009022,Elongation factor G, domain III;IPR035649,EFG, domain V;IPR000640,Elongation factor EFG, domain V-like","-","GO:0003746,molecular_function,translation elongation factor activity;GO:0005525,molecular_function,GTP binding;GO:0006414,biological_process,translational elongation;GO:0070125,biological_process,mitochondrial translational elongation;GO:0005622,cellular_component,intracellular;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0006412,biological_process,translation;GO:0005739,cellular_component,mitochondrion","-"]
["RP11-582J16.5",28.23617,11.2001323,1.333056656,5.784589159,{"v":4.62e-07,"d":"4.62E-07"},{"v":2.34E-6,"d":"2.34E-06"},"ENSG00000253200","H2QVV3,KIAA1967","XP_519650.3,cell cycle and apoptosis regulator protein 2 isoform X1;XP_003311685.1,-","PF14444,S1-like;PF14443,BC1","IPR011992,EF-hand domain pair;IPR025223,S1-like RNA binding domain;IPR028811,Cell cycle and apoptosis regulator protein 2;IPR025224,Cell cycle and apoptosis regulator protein;IPR025954,DBC1/CARP1 catalytically inactive NUDIX hydrolase domain","KOG4246,Predicted DNA-binding protein, contains SAP domain;ENOG4111FW4,-","GO:0009411,biological_process,response to UV;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:1902230,biological_process,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0043653,biological_process,mitochondrial fragmentation involved in apoptotic process;GO:0005634,cellular_component,nucleus;GO:0044609,cellular_component,DBIRD complex;GO:0005737,cellular_component,cytoplasm;GO:0005759,cellular_component,mitochondrial matrix;GO:0000790,cellular_component,nuclear chromatin;GO:0032784,biological_process,regulation of DNA-templated transcription, elongation;GO:0000993,molecular_function,RNA polymerase II core binding;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:2000003,biological_process,positive regulation of DNA damage checkpoint;GO:0030308,biological_process,negative regulation of cell growth;GO:0043086,biological_process,negative regulation of catalytic activity;GO:0031647,biological_process,regulation of protein stability;GO:0004857,molecular_function,enzyme inhibitor activity;GO:0005654,cellular_component,nucleoplasm;GO:0019899,molecular_function,enzyme binding;GO:0090311,biological_process,regulation of protein deacetylation;GO:0032435,biological_process,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0008380,biological_process,RNA splicing;GO:0005681,cellular_component,spliceosomal complex;GO:0042752,biological_process,regulation of circadian rhythm;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway;GO:0043065,biological_process,positive regulation of apoptotic process","-"]
["DDIT4",98.65326736,39.16676749,1.332365401,7.157240563,{"v":8.14e-09,"d":"8.14E-09"},{"v":6.1e-08,"d":"6.10E-08"},"ENSG00000168209","A0A024QZQ6,DNA-damage-inducible transcript 4, isoform CRA_a","NP_061931.1,DNA damage-inducible transcript 4 protein","PF07809,RTP801 C-terminal region","IPR038281,RTP801-like, C-terminal domain superfamily;IPR012918,RTP801-like","ENOG4111N0W,-;ENOG410IIEE,-","GO:0045820,biological_process,negative regulation of glycolytic process;GO:0009968,biological_process,negative regulation of signal transduction;GO:0071889,molecular_function,14-3-3 protein binding;GO:0005737,cellular_component,cytoplasm;GO:0032007,biological_process,negative regulation of TOR signaling;GO:0001666,biological_process,response to hypoxia;GO:0005739,cellular_component,mitochondrion;GO:0071549,biological_process,cellular response to dexamethasone stimulus;GO:0005829,cellular_component,cytosol;GO:0072593,biological_process,reactive oxygen species metabolic process;GO:0042771,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator","K08270,ko04150,mTOR signaling pathway;K08270,ko04151,PI3K-Akt signaling pathway;K08270,ko05206,MicroRNAs in cancer"]
["GNAI3",4.797439455,1.905160239,1.331774247,6.523278325,{"v":4.06E-8,"d":"4.06E-08"},{"v":2.61e-07,"d":"2.61E-07"},"ENSG00000065135","G1QRM5,G protein subunit alpha i3","-","PF00503,-protein alpha subunit","-","-","-","-"]
["NDST2",1.428638605,0.563237551,1.331454244,2.419786898,0.037097846,0.060500165,"ENSG00000166507","G3QTP6,N-deacetylase and N-sulfotransferase 2","XP_004049653.1,bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2","PF12062,heparan sulfate-N-deacetylase;PF00685,Sulfotransferase domain","IPR037359,Heparan sulfate sulfotransferase;IPR000863,Sulfotransferase domain;IPR021930,Heparan sulphate-N-deacetylase;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0008146,molecular_function,sulfotransferase activity;GO:0015016,molecular_function,[heparan sulfate]-glucosamine N-sulfotransferase activity;GO:0016787,molecular_function,hydrolase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K02577,ko00534,Glycosaminoglycan biosynthesis - heparan sulfate / heparin"]
["CACNB1",0.937254591,0.36951051,1.331454244,2.419786898,0.037097846,0.060500165,"ENSG00000067191","F7A9T0,Calcium voltage-gated channel auxiliary subunit beta 1","XP_001086857.2,-","PF12052,Voltage gated calcium channel subunit beta domain 4Aa N terminal;PF00625,uanylate kinase","IPR005443,Voltage-dependent calcium channel, L-type, beta-1 subunit;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036028,SH3-like domain superfamily;IPR000584,Voltage-dependent calcium channel, L-type, beta subunit;IPR001452,SH3 domain;IPR008145,Guanylate kinase/L-type calcium channel beta subunit","ENOG410XRDI,-;KOG3812,L-type voltage-dependent Ca2+ channel, beta subunit","GO:0007268,biological_process,chemical synaptic transmission;GO:0005245,molecular_function,voltage-gated calcium channel activity;GO:0007528,biological_process,neuromuscular junction development;GO:0005891,cellular_component,voltage-gated calcium channel complex;GO:0008331,molecular_function,high voltage-gated calcium channel activity;GO:1901385,biological_process,regulation of voltage-gated calcium channel activity;GO:0070588,biological_process,calcium ion transmembrane transport","K04862,ko05410,Hypertrophic cardiomyopathy (HCM);K04862,ko04921,Oxytocin signaling pathway;K04862,ko04260,Cardiac muscle contraction;K04862,ko04261,Adrenergic signaling in cardiomyocytes;K04862,ko05414,Dilated cardiomyopathy;K04862,ko04010,MAPK signaling pathway;K04862,ko05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC)"]
["TMEM161A",2.026480972,0.798935556,1.331454244,2.419786898,0.037097846,0.060500165,"ENSG00000064545","H2R692,Transmembrane protein 161A","XP_512520.3,transmembrane protein 161A isoform X3","PF10268,Predicted transmembrane protein 161AB","IPR019395,Transmembrane protein 161A/B","ENOG410XPZC,-;KOG3978,Predicted membrane protein","GO:0034644,biological_process,cellular response to UV;GO:0045739,biological_process,positive regulation of DNA repair;GO:0032526,biological_process,response to retinoic acid;GO:1902230,biological_process,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0034599,biological_process,cellular response to oxidative stress","-"]
["ALS2CL",0.734115498,0.289423381,1.331454244,2.419786898,0.037097846,0.060500165,"ENSG00000178038","A0A024R2U1,ALS2 C-terminal like, isoform CRA_c","NP_667340.2,ALS2 C-terminal-like protein isoform 1;NP_001177636.1,-","PF02493,MORN repeat;PF02204,Vacuolar sorting protein 9 (VPS9) domain","IPR037191,VPS9 domain superfamily;IPR003123,VPS9 domain;IPR003409,MORN motif;IPR035899,Dbl homology (DH) domain superfamily","KOG0231,Junctional membrane complex protein Junctophilin and related MORN repeat proteins;COG4642,Uncharacterized protein conserved in bacteria","-","-"]
["SVEP1",0.468561245,0.184729215,1.331454244,2.419786898,0.037097846,0.060500165,"ENSG00000165124","A0A0A0MSD0,Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1","-","PF07699,Putative ephrin-receptor like;PF00008,-like domain;PF00092,von Willebrand factor type A domain;PF02494,HYR domain;PF00084,Sushi repeat (SCR repeat);PF00354,Pentaxin family;PF12661,Human growth factor-like EGF;PF07645,Calcium-binding EGF domain","IPR018097,EGF-like calcium-binding, conserved site;IPR036465,von Willebrand factor A-like domain superfamily;IPR001759,Pentraxin-related;IPR000436,Sushi/SCR/CCP domain;IPR035976,Sushi/SCR/CCP superfamily;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR003410,HYR domain;IPR001881,EGF-like calcium-binding domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR011641,Tyrosine-protein kinase ephrin type A/B receptor-like;IPR002035,von Willebrand factor, type A","KOG4297,C-type lectin;KOG1217,Fibrillins and related proteins containing Ca2+-binding EGF-like domains;ENOG410XPJ1,-","GO:0005509,molecular_function,calcium ion binding","-"]
["ZNF703",6.168716823,2.445979733,1.330910286,3.930274585,0.000576244,0.001470583,"ENSG00000183779","H2QW06,Zinc finger protein 703","XP_519705.3,zinc finger protein 703","PF12402,NocA-like zinc-finger protein 1","IPR013087,Zinc finger C2H2-type;IPR022129,Transcriptional repressor NocA-like","ENOG410IH04,-;ENOG4111EZY,-","GO:0034111,biological_process,negative regulation of homotypic cell-cell adhesion;GO:0033601,biological_process,positive regulation of mammary gland epithelial cell proliferation;GO:0060828,biological_process,regulation of canonical Wnt signaling pathway;GO:0060644,biological_process,mammary gland epithelial cell differentiation;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0032991,cellular_component,protein-containing complex;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0070491,molecular_function,repressing transcription factor binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0071392,biological_process,cellular response to estradiol stimulus;GO:0016363,cellular_component,nuclear matrix;GO:0051726,biological_process,regulation of cell cycle;GO:0017015,biological_process,regulation of transforming growth factor beta receptor signaling pathway;GO:0034333,biological_process,adherens junction assembly;GO:0005634,cellular_component,nucleus;GO:0030335,biological_process,positive regulation of cell migration","-"]
["RICTOR",3.469897326,1.378362832,1.330336693,5.075630332,{"v":7.28e-06,"d":"7.28E-06"},{"v":2.86e-05,"d":"2.86E-05"},"ENSG00000164327","F7HVJ0,RPTOR independent companion of MTOR complex 2","XP_002745077.1,rapamycin-insensitive companion of mTOR isoform X1","PF14663,Rapamycin-insensitive companion of mTOR RasGEF_N domain;PF14664,Rapamycin-insensitive companion of mTOR, N-term;PF14668,Rapamycin-insensitive companion of mTOR, domain 5;PF14666,Rapamycin-insensitive companion of mTOR, middle domain;PF14665,Rapamycin-insensitive companion of mTOR, phosphorylation-site","IPR029453,Rapamycin-insensitive companion of mTOR, domain 4;IPR028268,Pianissimo family;IPR029451,Rapamycin-insensitive companion of mTOR, middle domain;IPR029452,Rapamycin-insensitive companion of mTOR, domain 5;IPR028267,Rapamycin-insensitive companion of mTOR, N-terminal domain;IPR029259,Rapamycin-insensitive companion of mTOR, phosphorylation-site;IPR016024,Armadillo-type fold","KOG3694,Protein required for meiosis;ENOG410XQ5Z,-","GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:0031929,biological_process,TOR signaling;GO:0019901,molecular_function,protein kinase binding;GO:0030838,biological_process,positive regulation of actin filament polymerization;GO:0051896,biological_process,regulation of protein kinase B signaling;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0050727,biological_process,regulation of inflammatory response;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0043022,molecular_function,ribosome binding;GO:0043087,biological_process,regulation of GTPase activity;GO:0031932,cellular_component,TORC2 complex;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0033135,biological_process,regulation of peptidyl-serine phosphorylation;GO:0032008,biological_process,positive regulation of TOR signaling;GO:0010468,biological_process,regulation of gene expression;GO:0009792,biological_process,embryo development ending in birth or egg hatching;GO:2000114,biological_process,regulation of establishment of cell polarity","K08267,ko04150,mTOR signaling pathway"]
["FOXN2",3.465938993,1.374978879,1.329874241,3.8154956,0.0006773,1.698052E-3,"ENSG00000170802","H2QHW2,Forkhead box N2","XP_016803992.1,-;XP_009440712.1,-;XP_001150448.1,-;XP_009440714.1,-;XP_016803994.1,-;XP_009440711.1,-;XP_016803993.1,-","PF00250,orkhead domain","IPR018122,Fork head domain conserved site1;IPR001766,Fork head domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR030456,Fork head domain conserved site 2;IPR036388,Winged helix-like DNA-binding domain superfamily","KOG2294,Transcription factor of the Forkhead/HNF3 family;COG5025,Transcription factor of the Forkhead/HNF3 family","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0030154,biological_process,cell differentiation;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005634,cellular_component,nucleus","-"]
["MPI",1.906995666,0.756978256,1.328640866,3.690690959,0.001226077,0.002907213,"ENSG00000178802","G3RFM0,Mannose-6-phosphate isomerase","XP_004056572.1,-","PF01238,Phosphomannose isomerase type I","IPR014710,RmlC-like jelly roll fold;IPR018050,Phosphomannose isomerase, type I, conserved site;IPR016305,Mannose-6-phosphate isomerase;IPR001250,Mannose-6-phosphate isomerase, type I;IPR011051,RmlC-like cupin domain superfamily","-","GO:0005975,biological_process,carbohydrate metabolic process;GO:0009298,biological_process,GDP-mannose biosynthetic process;GO:0046872,molecular_function,metal ion binding;GO:0061611,biological_process,mannose to fructose-6-phosphate metabolic process;GO:0016853,molecular_function,isomerase activity;GO:0004476,molecular_function,mannose-6-phosphate isomerase activity;GO:0008270,molecular_function,zinc ion binding","K01809,ko00051,Fructose and mannose metabolism;K01809,ko00520,Amino sugar and nucleotide sugar metabolism"]
["PITPNA",23.22979682,9.246355578,1.328344387,6.296305868,{"v":8.75e-08,"d":"8.75E-08"},{"v":5.2E-7,"d":"5.20E-07"},"ENSG00000174238","K7B5P5,Phosphatidylinositol transfer protein, alpha","XP_009429805.1,-","PF02121,Phosphatidylinositol transfer protein","IPR023393,START-like domain superfamily;IPR001666,Phosphatidylinositol transfer protein","COG5083,Uncharacterized protein involved in plasmid maintenance;KOG3668,Phosphatidylinositol transfer protein","GO:0015914,biological_process,phospholipid transport;GO:0005548,molecular_function,phospholipid transporter activity;GO:0005622,cellular_component,intracellular","-"]
["DCK",8.683079375,3.452295362,1.327971461,4.352130278,{"v":8.83e-05,"d":"8.83E-05"},0.000269143,"ENSG00000156136","D6RFG8,Deoxycytidine kinase","-","PF01712,eoxynucleoside kinase","IPR031314,Deoxynucleoside kinase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1428,Deoxynucleoside kinases;KOG4235,Mitochondrial thymidine kinase 2/deoxyguanosine kinase","GO:0005634,cellular_component,nucleus","-"]
["ARHGEF2",7.74637365,3.084735225,1.327314852,5.654338977,{"v":7.39e-07,"d":"7.39E-07"},{"v":3.59e-06,"d":"3.59E-06"},"ENSG00000116584","V9GYM8,Rho guanine nucleotide exchange factor 2","-","PF00621,RhoGEF domain","IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR037806,ARHGEF2, PH domain;IPR035899,Dbl homology (DH) domain superfamily;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR000219,Dbl homology (DH) domain","ENOG410XT68,-;ENOG410IR0Y,-","GO:0035556,biological_process,intracellular signal transduction;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0046872,molecular_function,metal ion binding;GO:0065009,biological_process,regulation of molecular function;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005622,cellular_component,intracellular;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity","-"]
["ANXA2",115.4738762,46.04518041,1.326370964,9.478883259,{"v":4.09e-10,"d":"4.09E-10"},{"v":4.12e-09,"d":"4.12E-09"},"ENSG00000182718","G3R2Q2,Annexin","-","PF00191,Annexin","IPR018502,Annexin repeat;IPR002389,Annexin A2;IPR001464,Annexin;IPR018252,Annexin repeat, conserved site;IPR037104,Annexin superfamily","-","GO:0098609,biological_process,cell-cell adhesion;GO:1905602,biological_process,positive regulation of receptor-mediated endocytosis involved in cholesterol transport;GO:0006900,biological_process,vesicle budding from membrane;GO:0001921,biological_process,positive regulation of receptor recycling;GO:0005886,cellular_component,plasma membrane;GO:0098772,molecular_function,molecular function regulator;GO:0044147,biological_process,negative regulation of development of symbiont involved in interaction with host;GO:0005576,cellular_component,extracellular region;GO:0009986,cellular_component,cell surface;GO:0005737,cellular_component,cytoplasm;GO:0005913,cellular_component,cell-cell adherens junction;GO:0031012,cellular_component,extracellular matrix;GO:0002020,molecular_function,protease binding;GO:0098641,molecular_function,cadherin binding involved in cell-cell adhesion;GO:0005544,molecular_function,calcium-dependent phospholipid binding;GO:0048306,molecular_function,calcium-dependent protein binding;GO:0005811,cellular_component,lipid droplet;GO:0042802,molecular_function,identical protein binding;GO:0030496,cellular_component,midbody;GO:0005546,molecular_function,phosphatidylinositol-4,5-bisphosphate binding;GO:1905599,biological_process,positive regulation of low-density lipoprotein receptor activity;GO:1905581,biological_process,positive regulation of low-density lipoprotein particle clearance;GO:0044090,biological_process,positive regulation of vacuole organization;GO:0005768,cellular_component,endosome;GO:0052362,biological_process,catabolism by host of symbiont protein;GO:1905597,biological_process,positive regulation of low-density lipoprotein particle receptor binding;GO:0043086,biological_process,negative regulation of catalytic activity;GO:1990667,cellular_component,PCSK9-AnxA2 complex;GO:0019834,molecular_function,phospholipase A2 inhibitor activity;GO:0031902,cellular_component,late endosome membrane;GO:0005509,molecular_function,calcium ion binding;GO:0005765,cellular_component,lysosomal membrane;GO:0070062,cellular_component,extracellular exosome;GO:0045121,cellular_component,membrane raft;GO:0032804,biological_process,negative regulation of low-density lipoprotein particle receptor catabolic process;GO:0001765,biological_process,membrane raft assembly;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0051290,biological_process,protein heterotetramerization;GO:0031340,biological_process,positive regulation of vesicle fusion;GO:0052405,biological_process,negative regulation by host of symbiont molecular function;GO:0001525,biological_process,angiogenesis;GO:0036035,biological_process,osteoclast development;GO:0004859,molecular_function,phospholipase inhibitor activity;GO:0044548,molecular_function,S100 protein binding","-"]
["ANKEF1",5.798682825,2.310266767,1.325446051,4.610676094,{"v":4.82e-05,"d":"4.82E-05"},1.57145E-4,"ENSG00000132623","Q8TCA8,Ankyrin repeat domain 5","-","PF12796,Ankyrin repeats (3 copies);PF13637,Ankyrin repeats (many copies)","IPR002048,EF-hand domain;IPR011992,EF-hand domain pair;IPR002110,Ankyrin repeat;IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily","COG0666,FOG: Ankyrin repeat;KOG4177,Ankyrin","GO:0005509,molecular_function,calcium ion binding","-"]
["MINPP1",4.645274725,1.846909339,1.325303565,3.402655398,0.002879112,0.006231816,"ENSG00000107789","B2R7D2,cDNA, FLJ93389, highly similar to Homo sapiens multiple inositol polyphosphate histidine phosphatase, 1","-","PF00328,Histidine phosphatase superfamily (branch 2)","IPR000560,Histidine phosphatase superfamily, clade-2;IPR029033,Histidine phosphatase superfamily;IPR016274,Histidine acid phosphatase, eukaryotic","ENOG4111FS8,-;KOG1382,Multiple inositol polyphosphate phosphatase","GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","-"]
["AC073333.8",21.62059965,8.596108899,1.325303565,3.402655398,0.002879112,0.006231816,"ENSG00000235837","Q3V199,Uncharacterized protein","-","-","IPR003307,W2 domain;IPR016024,Armadillo-type fold;IPR016021,MIF4G-like domain superfamily","KOG2297,Predicted translation factor, contains W2 domain;ENOG410XR08,-","-","-"]
["AMPD2",3.375880711,1.344654325,1.324780423,4.081646429,0.000258396,7.14564E-4,"ENSG00000116337","A0A024R098,AMP deaminase","NP_004028.3,AMP deaminase 2 isoform 1;NP_001244289.1,-","PF00962,Adenosine/AMP deaminase","IPR006329,AMP deaminase;IPR006650,Adenosine/AMP deaminase active site;IPR032466,Metal-dependent hydrolase;IPR029749,AMP deaminase 2;IPR001365,Adenosine/AMP deaminase domain","COG1816,Adenosine deaminase;KOG1096,Adenosine monophosphate deaminase","GO:0019239,molecular_function,deaminase activity;GO:0016787,molecular_function,hydrolase activity;GO:0003876,molecular_function,AMP deaminase activity;GO:0032264,biological_process,IMP salvage;GO:0009168,biological_process,purine ribonucleoside monophosphate biosynthetic process;GO:0046872,molecular_function,metal ion binding;GO:0005829,cellular_component,cytosol","K01490,ko00230,Purine metabolism"]
["BZW2",30.4768619,12.16882265,1.323855717,6.303636952,{"v":8.88e-08,"d":"8.88E-08"},{"v":5.28e-07,"d":"5.28E-07"},"ENSG00000136261","A0A096N1I7,Basic leucine zipper and W2 domains 2","XP_003896294.1,-;XP_003896293.1,-;XP_009201566.1,-;XP_009201565.1,-;XP_009201564.1,-","PF02020,eIF4-gamma/eIF5/eIF2-epsilon","IPR003307,W2 domain;IPR016024,Armadillo-type fold;IPR016021,MIF4G-like domain superfamily","-","GO:0005737,cellular_component,cytoplasm;GO:0045296,molecular_function,cadherin binding","-"]
["DSC2",3.186353902,1.27134794,1.32365293,4.829710179,{"v":1.77E-5,"d":"1.77E-05"},{"v":6.37e-05,"d":"6.37E-05"},"ENSG00000134755","A9X9K9,Desmocollin 2","-","PF08758,Cadherin prodomain like;PF00028,Cadherin domain;PF01049,Cadherin cytoplasmic region","IPR002126,Cadherin;IPR014868,Cadherin prodomain;IPR027397,Catenin binding domain superfamily;IPR000233,Cadherin, cytoplasmic domain;IPR009122,Desmosomal cadherin;IPR015919,Cadherin-like;IPR020894,Cadherin conserved site","ENOG410XQHI,-;KOG3594,FOG: Cadherin repeats","GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["TBC1D10B",15.06501892,6.016211934,1.323535552,6.160204599,{"v":1.57e-07,"d":"1.57E-07"},{"v":8.83e-07,"d":"8.83E-07"},"ENSG00000169221","H2R0A3,Uncharacterized protein","XP_016784237.1,TBC1 domain family member 10B isoform X1","PF00566,Rab-GTPase-TBC domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain","KOG2221,PDZ-domain interacting protein EPI64, contains TBC domain;ENOG410XPSR,-","GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0012505,cellular_component,endomembrane system;GO:0090630,biological_process,activation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity;GO:0031338,biological_process,regulation of vesicle fusion;GO:0017137,molecular_function,Rab GTPase binding;GO:0043087,biological_process,regulation of GTPase activity;GO:0005886,cellular_component,plasma membrane;GO:0005622,cellular_component,intracellular;GO:0005829,cellular_component,cytosol;GO:0006886,biological_process,intracellular protein transport","-"]
["ZNF8",1.3527528,0.538447817,1.322967506,3.233399668,3.663412E-3,0.007772615,"ENSG00000278129","B3KS94,cDNA FLJ35791 fis, clone TESTI2005743, highly similar to ZINC FINGER PROTEIN 8","NP_066575.2,zinc finger protein 8","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["MPZL3",7.24109818,2.890176557,1.322454555,4.388460426,0.000123038,0.000364919,"ENSG00000160588","G3QNN4,Myelin protein zero like 3","XP_004052258.1,myelin protein zero-like protein 3 isoform X2","PF07686,Immunoglobulin V-set domain","IPR007110,Immunoglobulin-like domain;IPR000920,Myelin P0 protein-related;IPR029862,Myelin protein zero-like protein 3;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR013106,Immunoglobulin V-set domain","-","GO:0042633,biological_process,hair cycle;GO:0030198,biological_process,extracellular matrix organization;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PBX1",5.051154674,2.020043828,1.321532787,6.248576799,{"v":1.14E-7,"d":"1.14E-07"},{"v":6.62e-07,"d":"6.62E-07"},"ENSG00000185630","G3R6Q4,PBX homeobox 1","XP_018881599.1,-","PF03792,PBC domain;PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR005542,PBX","-","GO:0030278,biological_process,regulation of ossification;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0048706,biological_process,embryonic skeletal system development;GO:0046982,molecular_function,protein heterodimerization activity;GO:0009887,biological_process,animal organ morphogenesis;GO:0005634,cellular_component,nucleus;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0010971,biological_process,positive regulation of G2/M transition of mitotic cell cycle;GO:0001658,biological_process,branching involved in ureteric bud morphogenesis;GO:0042127,biological_process,regulation of cell proliferation;GO:0045665,biological_process,negative regulation of neuron differentiation;GO:0003677,molecular_function,DNA binding;GO:0001655,biological_process,urogenital system development;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0035162,biological_process,embryonic hemopoiesis;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0090575,cellular_component,RNA polymerase II transcription factor complex;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0030325,biological_process,adrenal gland development;GO:0005654,cellular_component,nucleoplasm;GO:0048538,biological_process,thymus development;GO:0005667,cellular_component,transcription factor complex;GO:0048536,biological_process,spleen development;GO:0009954,biological_process,proximal/distal pattern formation;GO:0048568,biological_process,embryonic organ development;GO:0009952,biological_process,anterior/posterior pattern specification","K09355,ko05202,Transcriptional misregulation in cancer"]
["TLN1",9.372810155,3.750637421,1.320562676,6.074653738,{"v":2.25e-07,"d":"2.25E-07"},{"v":1.22E-6,"d":"1.22E-06"},"ENSG00000137076","K7DQB8,Talin 1","-","PF01608,I/LWEQ domain;PF08913,Vinculin Binding Site;PF16511,N-terminal or F0 domain of Talin-head FERM;PF09379,RM N-terminal domain;PF09141,Talin, middle domain;PF00373,RM central domain","IPR019747,FERM conserved site;IPR019748,FERM central domain;IPR035964,I/LWEQ domain superfamily;IPR015224,Talin, central;IPR018979,FERM, N-terminal;IPR000299,FERM domain;IPR015009,Vinculin-binding site-containing domain;IPR036723,Alpha-catenin/vinculin-like superfamily;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR032425,Talin, N-terminal F0 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR036476,Talin, central domain superfamily;IPR029071,Ubiquitin-like domain superfamily;IPR011993,PH-like domain superfamily;IPR037438,Talin-1/2, rod-segment;IPR002558,I/LWEQ domain","KOG4261,Talin;ENOG410XQ0V,-","GO:0007155,biological_process,cell adhesion;GO:0001726,cellular_component,ruffle;GO:0005856,cellular_component,cytoskeleton;GO:0003779,molecular_function,actin binding;GO:0007016,biological_process,cytoskeletal anchoring at plasma membrane;GO:0051015,molecular_function,actin filament binding;GO:0005925,cellular_component,focal adhesion;GO:0005200,molecular_function,structural constituent of cytoskeleton","-"]
["TMEM33",1.296809046,0.516944756,1.319912721,3.041267569,0.007645969,0.015025837,"ENSG00000109133","G3R183,Transmembrane protein 33","XP_018881318.1,-;XP_018881317.1,-;XP_018881319.1,-;XP_004038661.1,-;XP_018881316.1,-;XP_018881315.1,-","PF03661,Uncharacterised protein family (UPF0121)","IPR005344,TMEM33/Pom33 family","-","GO:1903899,biological_process,positive regulation of PERK-mediated unfolded protein response;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:1903896,biological_process,positive regulation of IRE1-mediated unfolded protein response;GO:0005783,cellular_component,endoplasmic reticulum;GO:0042470,cellular_component,melanosome;GO:1903371,biological_process,regulation of endoplasmic reticulum tubular network organization;GO:0016020,cellular_component,membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0005635,cellular_component,nuclear envelope;GO:0016021,cellular_component,integral component of membrane","-"]
["HGH1",3.797337078,1.513725937,1.319912721,3.041267569,0.007645969,0.015025837,"ENSG00000235173","H2PRG0,HGH1 homolog","XP_002819599.1,protein FAM203A","PF04064,omain of unknown function (DUF384);PF04063,omain of unknown function (DUF383)","IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR007205,Protein HGH1 N-terminal;IPR007206,Protein HGH1 C-terminal","ENOG410YNU7,-;KOG2973,Uncharacterized conserved protein","-","-"]
["PDPR",1.737792108,0.694135368,1.319843204,3.74788307,0.000907958,0.002205882,"ENSG00000090857","K7AIK2,Pyruvate dehydrogenase phosphatase regulatory subunit","-","PF01571,Aminomethyltransferase folate-binding domain;PF16350,AD dependent oxidoreductase central domain;PF00890,AD binding domain;PF01266,AD dependent oxidoreductase;PF08669,lycine cleavage T-protein C-terminal barrel domain","IPR036188,FAD/NAD(P)-binding domain superfamily;IPR006222,Aminomethyltransferase, folate-binding domain;IPR006076,FAD dependent oxidoreductase;IPR032503,FAD dependent oxidoreductase, central domain;IPR013977,Glycine cleavage T-protein, C-terminal barrel domain;IPR029043,Glycine cleavage T-protein/YgfZ, C-terminal;IPR027266,GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1","COG0404,Glycine cleavage system T protein (aminomethyltransferase);KOG2844,Dimethylglycine dehydrogenase precursor","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity","-"]
["POLR3C",11.73272469,4.692637953,1.31979777,4.572279713,{"v":5.91E-5,"d":"5.91E-05"},0.000188632,"ENSG00000186141","H2PZU3,Polymerase","XP_001161607.1,-","PF05645,RNA polymerase III subunit RPC82;PF08221,RNA polymerase III subunit RPC82 helix-turn-helix domain","IPR036388,Winged helix-like DNA-binding domain superfamily;IPR008806,RNA polymerase III Rpc82, C -terminal;IPR013197,RNA polymerase III subunit RPC82-related, helix-turn-helix","KOG2587,RNA polymerase III (C) subunit;ENOG410XPVH,-","GO:0003697,molecular_function,single-stranded DNA binding;GO:0032728,biological_process,positive regulation of interferon-beta production;GO:0003677,molecular_function,DNA binding;GO:0045089,biological_process,positive regulation of innate immune response;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0001056,molecular_function,RNA polymerase III activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0005666,cellular_component,DNA-directed RNA polymerase III complex;GO:0005654,cellular_component,nucleoplasm;GO:0006383,biological_process,transcription by RNA polymerase III","K03023,ko00240,Pyrimidine metabolism;K03023,ko05169,Epstein-Barr virus infection;K03023,ko04623,Cytosolic DNA-sensing pathway;K03023,ko03020,RNA polymerase;K03023,ko00230,Purine metabolism"]
["COQ10B",16.83681412,6.741055446,1.318952153,5.042695129,{"v":9.91E-6,"d":"9.91E-06"},{"v":3.77e-05,"d":"3.77E-05"},"ENSG00000115520","G3SBK5,Coenzyme Q10B","-","PF03364,Polyketide cyclase / dehydrase and lipid transport","IPR023393,START-like domain superfamily;IPR005031,Coenzyme Q-binding protein COQ10, START domain","-","-","-"]
["AGGF1",14.57387548,5.838390429,1.318733472,5.71271646,{"v":7.69e-07,"d":"7.69E-07"},{"v":3.72E-6,"d":"3.72E-06"},"ENSG00000164252","Q6PIK7,Angiogenic factor with G patch and FHA domains 1","-","PF01585,-patch domain;PF00498,HA domain","IPR000467,G-patch domain;IPR035624,AGGF1, OCRE domain;IPR008984,SMAD/FHA domain superfamily;IPR000253,Forkhead-associated (FHA) domain","ENOG410ZKVJ,-;ENOG410IQDU,-","GO:0005515,molecular_function,protein binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["TRMT1L",4.802025183,1.921585421,1.318219071,4.12539377,0.000247954,0.000688698,"ENSG00000121486","B2R713,cDNA, FLJ93224","-","PF02475,Met-10+ like-protein;PF02005,N2,N2-dimethylguanosine tRNA methyltransferase","IPR013087,Zinc finger C2H2-type;IPR002905,tRNA methyltransferase, Trm1;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase","COG1867,N2,N2-dimethylguanosine tRNA methyltransferase;KOG1253,tRNA methyltransferase","GO:0004809,molecular_function,tRNA (guanine-N2-)-methyltransferase activity;GO:0003676,molecular_function,nucleic acid binding;GO:0030488,biological_process,tRNA methylation;GO:0016740,molecular_function,transferase activity;GO:0003723,molecular_function,RNA binding;GO:0008168,molecular_function,methyltransferase activity;GO:0000049,molecular_function,tRNA binding;GO:0032259,biological_process,methylation;GO:0008033,biological_process,tRNA processing","-"]
["CLIP1",15.94435641,6.395198891,1.317699372,7.515004711,{"v":5.35e-09,"d":"5.35E-09"},{"v":4.17e-08,"d":"4.17E-08"},"ENSG00000130779","G3QI01,CAP-Gly domain containing linker protein 1","-","PF16641,CLIP1 zinc knuckle;PF01302,CAP-Gly domain","IPR000938,CAP Gly-rich domain;IPR032108,CLIP1, zinc knuckle;IPR036859,CAP Gly-rich domain superfamily","-","GO:0044861,biological_process,protein transport into plasma membrane raft;GO:0005813,cellular_component,centrosome;GO:0001578,biological_process,microtubule bundle formation;GO:0031116,biological_process,positive regulation of microtubule polymerization;GO:0016020,cellular_component,membrane;GO:0051010,molecular_function,microtubule plus-end binding;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0044354,cellular_component,macropinosome;GO:0008017,molecular_function,microtubule binding;GO:0005874,cellular_component,microtubule;GO:0005881,cellular_component,cytoplasmic microtubule;GO:0005635,cellular_component,nuclear envelope;GO:0015631,molecular_function,tubulin binding;GO:0008270,molecular_function,zinc ion binding;GO:0035371,cellular_component,microtubule plus-end","-"]
["EXOC2",3.288129646,1.315125206,1.317536824,3.61673234,0.001088553,0.002610728,"ENSG00000112685","A0A024QZT2,Exocyst complex component 2, isoform CRA_a","XP_016866509.1,-;XP_016866512.1,-;XP_016866508.1,-;XP_016866511.1,-;XP_016866510.1,-;NP_060773.3,exocyst complex component 2;XP_016866507.1,-;XP_016866513.1,-","PF01833,IPT/TIG domain;PF15469,xocyst complex component Sec5","IPR002909,IPT domain;IPR029175,Exocyst complex component EXOC2/Sec5;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set","KOG2347,Sec5 subunit of exocyst complex;ENOG410XSY3,-","GO:0047485,molecular_function,protein N-terminus binding;GO:0017160,molecular_function,Ral GTPase binding;GO:0000145,cellular_component,exocyst;GO:0006893,biological_process,Golgi to plasma membrane transport","K17637,ko04014,Ras signaling pathway"]
["CENPA",17.72269365,7.105157911,1.3165514,4.670875137,{"v":3.87e-05,"d":"3.87E-05"},1.28684E-4,"ENSG00000115163","G3S1D8,Centromere protein A","-","PF00125,Core histone H2A/H2B/H3/H4","-","-","-","-"]
["AMMECR1L",4.638477948,1.858204793,1.316386695,4.025753159,0.000417566,0.001101801,"ENSG00000144233","I3M6A7,AMMECR1 like","XP_013220105.1,-;XP_005315922.1,-;XP_013220126.1,-","PF01871,AMMECR1","IPR002733,AMMECR1 domain;IPR023473,AMMECR1;IPR027485,AMMECR1, N-terminal;IPR036071,AMMECR1 domain superfamily","COG2078,Uncharacterized conserved protein;KOG3274,Uncharacterized conserved protein, AMMECR1","-","-"]
["CINP",1.688526482,0.674456942,1.315747202,2.819042306,0.016698556,0.03001227,"ENSG00000100865","A0A1D5Q7U3,Cyclin dependent kinase 2 interacting protein","-","-","IPR023250,Cyclin-dependent kinase 2-interacting protein","-","-","-"]
["LL0XNC01-237H1.2",7.964241413,3.181198496,1.315747202,2.819042306,0.016698556,0.03001227,"-","-","-","-","-","-","-","-"]
["SLMAP",6.344803486,2.547747152,1.315529412,5.995505893,{"v":3.36e-07,"d":"3.36E-07"},{"v":1.74e-06,"d":"1.74E-06"},"ENSG00000163681","G3SKN0,Sarcolemma associated protein","XP_018879915.1,-","PF00498,HA domain","IPR008984,SMAD/FHA domain superfamily;IPR030498,Sarcolemmal membrane-associated protein;IPR000253,Forkhead-associated (FHA) domain","-","GO:1905150,biological_process,regulation of voltage-gated sodium channel activity;GO:0016020,cellular_component,membrane;GO:0072659,biological_process,protein localization to plasma membrane;GO:1902305,biological_process,regulation of sodium ion transmembrane transport;GO:0006936,biological_process,muscle contraction;GO:1900825,biological_process,regulation of membrane depolarization during cardiac muscle cell action potential;GO:0016021,cellular_component,integral component of membrane","-"]
["TMED4",18.39701842,7.389597461,1.314838415,5.628916864,{"v":1.04E-6,"d":"1.04E-06"},{"v":4.9e-06,"d":"4.90E-06"},"ENSG00000158604","G3R8N7,Transmembrane p24 trafficking protein 4","XP_004045432.1,-","PF01105,emp24/gp25L/p24 family/GOLD","IPR009038,GOLD domain;IPR015720,TMP21-related","-","GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF224",2.07242807,0.830228324,1.314715881,3.472301318,0.002063944,0.004643514,"ENSG00000267680","A0A024R0Q3,Zinc finger protein 224, isoform CRA_a","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["GAS2L1",3.285545416,1.316211116,1.314715881,3.472301318,0.002063944,0.004643514,"ENSG00000185340","A0A5E8,GAS2-like protein 1","NP_006469.2,GAS2-like protein 1 isoform a;NP_689422.1,-;XP_011528126.1,-;XP_011528127.1,-;XP_016884022.1,-","PF02187,rowth-Arrest-Specific Protein 2 Domain;PF00307,Calponin homology (CH) domain","IPR003108,GAR domain;IPR036534,GAR domain superfamily;IPR029931,GAS2-like protein 1;IPR036872,CH domain superfamily;IPR001715,Calponin homology domain","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);KOG0516,Dystonin, GAS (Growth-arrest-specific protein), and related proteins","GO:0005856,cellular_component,cytoskeleton;GO:0008093,molecular_function,cytoskeletal adaptor activity;GO:0008017,molecular_function,microtubule binding","-"]
["TRABD",4.669371712,1.870581038,1.314715881,3.472301318,0.002063944,0.004643514,"ENSG00000170638","J3KPT4,TraB domain-containing protein","XP_006724485.1,-;XP_006724486.1,-;NP_001307417.1,traB domain-containing protein isoform c","PF01963,TraB family","IPR002816,Pheromone shutdown, TraB","KOG2860,Uncharacterized conserved protein, contains TraB domain;COG1916,Uncharacterized homolog of PrgY (pheromone shutdown protein)","-","-"]
["RP11-522I20.3",12.98282981,5.201007065,1.314715881,3.472301318,0.002063944,0.004643514,"ENSG00000254473","U3CZH8,Histone-lysine N-methyltransferase SETMAR isoform 1","-","PF00856,SET domain;PF01359,Transposase (partial DDE domain);PF05033,Pre-SET motif","IPR003616,Post-SET domain;IPR001214,SET domain;IPR001888,Transposase, type 1;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR007728,Pre-SET domain","COG2940,Proteins containing SET domain;KOG1082,Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing","GO:0005694,cellular_component,chromosome;GO:0034968,biological_process,histone lysine methylation;GO:0016740,molecular_function,transferase activity;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["RXRB",5.20958482,2.089690339,1.314259448,3.918654151,0.000720329,0.001794189,"ENSG00000204231","H2QSS5,Retinoid X receptor beta","XP_009449278.1,-","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR000003,Retinoid X receptor/HNF4;IPR013088,Zinc finger, NHR/GATA-type","KOG3575,FOG: Hormone receptors;ENOG410XRZC,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0004879,molecular_function,nuclear receptor activity;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006351,biological_process,transcription, DNA-templated;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway","-"]
["RNF167",15.7499076,6.328776454,1.31363677,4.961594996,{"v":1.2E-5,"d":"1.20E-05"},{"v":4.48e-05,"d":"4.48E-05"},"ENSG00000108523","A0A1U7U208,E3 ubiquitin-protein ligase RNF167","XP_008064115.1,E3 ubiquitin-protein ligase RNF167 isoform X2","-","IPR001841,Zinc finger, RING-type;IPR011016,Zinc finger, RING-CH-type;IPR003137,PA domain;IPR013083,Zinc finger, RING/FYVE/PHD-type","-","GO:0000209,biological_process,protein polyubiquitination;GO:0016021,cellular_component,integral component of membrane;GO:0045786,biological_process,negative regulation of cell cycle;GO:0005737,cellular_component,cytoplasm;GO:0046872,molecular_function,metal ion binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016020,cellular_component,membrane;GO:0008270,molecular_function,zinc ion binding;GO:0016874,molecular_function,ligase activity","-"]
["RP5-1052I5.2",17.81245998,7.162042515,1.312387773,4.70005684,{"v":3.18E-5,"d":"3.18E-05"},1.07858E-4,"ENSG00000267561","F7HU07,Heparan sulfate 2-O-sulfotransferase 1","-","PF03567,Sulfotransferase family","IPR005331,Sulfotransferase;IPR007734,Heparan sulphate 2-O-sulfotransferase;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0008146,molecular_function,sulfotransferase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["CBLC",15.48980048,6.225397943,1.312066565,4.167849066,2.81255E-4,0.000771475,"ENSG00000142273","F7FKP6,Uncharacterized protein","XP_001109370.1,E3 ubiquitin-protein ligase CBL-C isoform X2","PF02761,CBL proto-oncogene N-terminus, EF hand-like domain;PF02262,CBL proto-oncogene N-terminal domain 1;PF02762,CBL proto-oncogene N-terminus, SH2-like domain;PF14447,Prokaryotic RING finger family 4","IPR017907,Zinc finger, RING-type, conserved site;IPR036537,Adaptor protein Cbl, N-terminal domain superfamily;IPR003153,Adaptor protein Cbl, N-terminal helical;IPR036860,SH2 domain superfamily;IPR001841,Zinc finger, RING-type;IPR024162,Adaptor protein Cbl;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011992,EF-hand domain pair;IPR014741,Adaptor protein Cbl, EF hand-like;IPR024159,Adaptor protein Cbl, PTB domain;IPR014742,Adaptor protein Cbl, SH2-like domain","ENOG410YDNH,-;KOG1785,Tyrosine kinase negative regulator CBL","GO:0006508,biological_process,proteolysis;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:0016567,biological_process,protein ubiquitination;GO:0023051,biological_process,regulation of signaling;GO:0007175,biological_process,negative regulation of epidermal growth factor-activated receptor activity;GO:0004871,molecular_function,signal transducer activity;GO:0005509,molecular_function,calcium ion binding;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:0045121,cellular_component,membrane raft;GO:0017124,molecular_function,SH3 domain binding;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0007173,biological_process,epidermal growth factor receptor signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0030971,molecular_function,receptor tyrosine kinase binding;GO:0005634,cellular_component,nucleus","K04707,ko05100,Bacterial invasion of epithelial cells;K04707,ko05220,Chronic myeloid leukemia;K04707,ko05200,Pathways in cancer;K04707,ko04012,ErbB signaling pathway;K04707,ko04144,Endocytosis;K04707,ko04120,Ubiquitin mediated proteolysis;K04707,ko05205,Proteoglycans in cancer;K04707,ko04660,T cell receptor signaling pathway;K04707,ko04910,Insulin signaling pathway"]
["MSX2",24.37366249,9.815468839,1.310864219,5.310489658,{"v":3.93e-06,"d":"3.93E-06"},{"v":1.64e-05,"d":"1.64E-05"},"ENSG00000120149","G1QI88,Msh homeobox 2","XP_003273299.1,homeobox protein MSX-2","PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR020479,Homeobox domain, metazoa;IPR009057,Homeobox-like domain superfamily","KOG0492,Transcription factor MSH, contains HOX domain;ENOG410YT2J,-","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0016607,cellular_component,nuclear speck;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","K09341,ko05166,HTLV-I infection"]
["RBFOX2",18.99396608,7.656605367,1.310377916,7.069913933,{"v":1.71e-08,"d":"1.71E-08"},{"v":1.2e-07,"d":"1.20E-07"},"ENSG00000100320","H9ENR7,RNA binding protein fox-1 homolog 2 isoform 5","NP_001248445.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF12414,Calcitonin gene-related peptide regulator C terminal","IPR034237,FOX1, RNA recognition motif;IPR017325,RNA binding protein Fox-1;IPR025670,Fox-1 C-terminal domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily","KOG0125,Ataxin 2-binding protein (RRM superfamily);ENOG4111WJT,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0043484,biological_process,regulation of RNA splicing","-"]
["PRR4",2.43267168,0.974544285,1.309730509,2.555432472,0.023844974,0.040975672,"ENSG00000111215","A0A087WY73,Proline-rich protein 4","-","PF15240,Proline-rich","IPR026086,Proline-rich protein","-","-","-"]
["SULF1",0.782780147,0.313586879,1.309730509,2.555432472,0.023844974,0.040975672,"ENSG00000137573","A0A024R809,Sulfatase 1, isoform CRA_a","NP_001121676.1,-;NP_001121677.1,-;NP_001121678.1,-;NP_055985.2,extracellular sulfatase Sulf-1 precursor","PF12548,Sulfatase protein;PF00884,Sulfatase","IPR017850,Alkaline-phosphatase-like, core domain superfamily;IPR024607,Sulfatase, conserved site;IPR017849,Alkaline phosphatase-like, alpha/beta/alpha;IPR024609,Extracellular sulfatase, C-terminal;IPR000917,Sulfatase, N-terminal;IPR014615,Extracellular sulfatase","KOG3731,Sulfatases;COG3119,Arylsulfatase A and related enzymes","GO:0005783,cellular_component,endoplasmic reticulum;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0060384,biological_process,innervation;GO:0060686,biological_process,negative regulation of prostatic bud formation;GO:0005794,cellular_component,Golgi apparatus;GO:0003824,molecular_function,catalytic activity;GO:0010575,biological_process,positive regulation of vascular endothelial growth factor production;GO:0001822,biological_process,kidney development;GO:0040037,biological_process,negative regulation of fibroblast growth factor receptor signaling pathway;GO:0048706,biological_process,embryonic skeletal system development;GO:0014846,biological_process,esophagus smooth muscle contraction;GO:0002063,biological_process,chondrocyte development;GO:0009986,cellular_component,cell surface;GO:0003094,biological_process,glomerular filtration;GO:0008152,biological_process,metabolic process;GO:0008484,molecular_function,sulfuric ester hydrolase activity;GO:0060348,biological_process,bone development;GO:0046872,molecular_function,metal ion binding;GO:0032836,biological_process,glomerular basement membrane development;GO:0030201,biological_process,heparan sulfate proteoglycan metabolic process;GO:0008449,molecular_function,N-acetylglucosamine-6-sulfatase activity;GO:0035860,biological_process,glial cell-derived neurotrophic factor receptor signaling pathway;GO:0051216,biological_process,cartilage development","-"]
["LYNX1",1.218954215,0.488321081,1.309730509,2.555432472,0.023844974,0.040975672,"ENSG00000180155","G3RFI8,Uncharacterized protein","XP_004047640.1,ly-6/neurotoxin-like protein 1","PF00021,u-PAR/Ly-6 domain","IPR016054,Ly-6 antigen/uPA receptor-like","-","-","-"]
["DNAJC8",54.26720772,21.89717621,1.308867627,6.793034234,{"v":3.3e-08,"d":"3.30E-08"},{"v":2.17E-7,"d":"2.17E-07"},"ENSG00000126698","F7IH53,DnaJ homolog subfamily C member 8","XP_002750556.1,-","PF00226,naJ domain","IPR036869,Chaperone J-domain superfamily;IPR001623,DnaJ domain","ENOG4110ZJ4,-;KOG1150,Predicted molecular chaperone (DnaJ superfamily)","GO:0005829,cellular_component,cytosol;GO:0045171,cellular_component,intercellular bridge;GO:0005654,cellular_component,nucleoplasm;GO:0030544,molecular_function,Hsp70 protein binding;GO:0005634,cellular_component,nucleus","-"]
["MTERF3",9.493131849,3.820617627,1.308781017,3.676899826,1.557178E-3,3.604669E-3,"ENSG00000156469","H2QWG6,mTERF domain containing 1","XP_519867.1,-","PF02536,mTERF","IPR003690,Transcription termination factor, mitochondrial/chloroplastic;IPR038538,MTERF superfamily, mitochondrial/chloroplastic","KOG1267,Mitochondrial transcription termination factor, mTERF;ENOG410XT49,-","GO:0003727,molecular_function,single-stranded RNA binding;GO:0019843,molecular_function,rRNA binding;GO:0008380,biological_process,RNA splicing;GO:0003690,molecular_function,double-stranded DNA binding;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0032502,biological_process,developmental process;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0005739,cellular_component,mitochondrion;GO:0042255,biological_process,ribosome assembly;GO:0005654,cellular_component,nucleoplasm","-"]
["CCAR2",20.49701897,8.274329421,1.308152333,6.56840945,{"v":5.7e-08,"d":"5.70E-08"},{"v":3.55e-07,"d":"3.55E-07"},"ENSG00000158941","G3QJ10,Cell cycle and apoptosis regulator 2","XP_004046802.1,-;XP_004046801.1,cell cycle and apoptosis regulator protein 2","PF14444,S1-like;PF14443,BC1","IPR011992,EF-hand domain pair;IPR025223,S1-like RNA binding domain;IPR028811,Cell cycle and apoptosis regulator protein 2;IPR025224,Cell cycle and apoptosis regulator protein;IPR025954,DBC1/CARP1 catalytically inactive NUDIX hydrolase domain","-","GO:0009411,biological_process,response to UV;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:1902230,biological_process,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0043653,biological_process,mitochondrial fragmentation involved in apoptotic process;GO:0005634,cellular_component,nucleus;GO:0044609,cellular_component,DBIRD complex;GO:0005737,cellular_component,cytoplasm;GO:0005759,cellular_component,mitochondrial matrix;GO:0000790,cellular_component,nuclear chromatin;GO:0032784,biological_process,regulation of DNA-templated transcription, elongation;GO:0000993,molecular_function,RNA polymerase II core binding;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:2000003,biological_process,positive regulation of DNA damage checkpoint;GO:0030308,biological_process,negative regulation of cell growth;GO:0043086,biological_process,negative regulation of catalytic activity;GO:0031647,biological_process,regulation of protein stability;GO:0004857,molecular_function,enzyme inhibitor activity;GO:0005654,cellular_component,nucleoplasm;GO:0019899,molecular_function,enzyme binding;GO:0090311,biological_process,regulation of protein deacetylation;GO:0032435,biological_process,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0008380,biological_process,RNA splicing;GO:0005681,cellular_component,spliceosomal complex;GO:0042752,biological_process,regulation of circadian rhythm;GO:0090263,biological_process,positive regulation of canonical Wnt signaling pathway;GO:0043065,biological_process,positive regulation of apoptotic process","-"]
["NRG1",2.725089944,1.099153506,1.307535986,4.492253035,{"v":7.68e-05,"d":"7.68E-05"},2.38354E-4,"ENSG00000157168","H0YBA3,Pro-neuregulin-1, membrane-bound isoform","-","PF02158,Neuregulin family;PF07679,Immunoglobulin I-set domain","IPR007110,Immunoglobulin-like domain;IPR002154,Neuregulin, C-terminal;IPR003599,Immunoglobulin subtype;IPR036179,Immunoglobulin-like domain superfamily;IPR018250,Neuregulin-1;IPR013783,Immunoglobulin-like fold;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set","ENOG4110ST7,-;ENOG410IEU9,-","GO:0005102,molecular_function,signaling receptor binding;GO:0009790,biological_process,embryo development;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CNOT3",23.68910377,9.570756709,1.307055699,6.806498633,{"v":3.44e-08,"d":"3.44E-08"},{"v":2.25e-07,"d":"2.25E-07"},"ENSG00000088038","H2R0F5,CCR4-NOT transcription complex subunit 3","XP_016792263.1,-;XP_512885.3,-","PF04065,Not1 N-terminal domain, CCR4-Not complex component;PF04153,NOT2 / NOT3 / NOT5 family","IPR007207,CCR4-Not complex component, Not N-terminal domain;IPR012270,CCR4-NOT complex, subunit 3/ 5;IPR038635,CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily;IPR007282,NOT2/NOT3/NOT5","KOG2150,CCR4-NOT transcriptional regulation complex, NOT5 subunit;COG5665,CCR4-NOT transcriptional regulation complex, NOT5 subunit","GO:0000932,cellular_component,P-body;GO:2000036,biological_process,regulation of stem cell population maintenance;GO:0030015,cellular_component,CCR4-NOT core complex;GO:0000288,biological_process,nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0017148,biological_process,negative regulation of translation;GO:0005634,cellular_component,nucleus","-"]
["PPA1",15.84292209,6.399924184,1.30681802,5.867979377,{"v":5.54e-07,"d":"5.54E-07"},{"v":2.77e-06,"d":"2.77E-06"},"ENSG00000180817","V9HWB5,Epididymis secretory sperm binding protein Li 66p","NP_066952.1,inorganic pyrophosphatase","PF00719,Inorganic pyrophosphatase","IPR008162,Inorganic pyrophosphatase;IPR036649,Inorganic pyrophosphatase superfamily","KOG1626,Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38;COG0221,Inorganic pyrophosphatase","GO:0005737,cellular_component,cytoplasm;GO:0016462,molecular_function,pyrophosphatase activity;GO:0006796,biological_process,phosphate-containing compound metabolic process;GO:0004427,molecular_function,inorganic diphosphatase activity;GO:0000287,molecular_function,magnesium ion binding","K01507,ko00190,Oxidative phosphorylation"]
["WLS",2.550478177,1.026468613,1.306643644,3.130371728,5.263785E-3,0.010730946,"ENSG00000116729","K7CQ82,Wntless homolog","XP_016776078.1,-","PF06664,Wnt-binding factor required for Wnt secretion","IPR009551,Protein wntless","ENOG410IG2W,-;ENOG410XQ06,-","GO:0017147,molecular_function,Wnt-protein binding;GO:0016055,biological_process,Wnt signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["BSCL2",2.874675151,1.156945329,1.306643644,3.130371728,5.263785E-3,0.010730946,"ENSG00000168000","G3QL04,BSCL2, seipin lipid droplet biogenesis associated","-","PF06775,Putative adipose-regulatory protein (Seipin)","IPR009617,Seipin family","-","GO:0019915,biological_process,lipid storage;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF343",2.454897044,0.988000911,1.306643644,3.130371728,5.263785E-3,0.010730946,"ENSG00000088876","A0A087WZQ2,Zinc finger protein 343","NP_001308730.1,-;NP_001269426.1,zinc finger protein 343 isoform 2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["IFT22",6.09166878,2.458268828,1.306285795,4.209086602,0.000269446,0.00074161,"ENSG00000128581","H2QV55,RAB, member RAS oncogene family-like 5","XP_016801536.1,-;XP_003318735.1,-","PF08477,Ras of Complex, Roc, domain of DAPkinase","IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410IVWX,-;ENOG4111FYS,-","-","-"]
["RP11-574F21.3",30.72527793,12.42271844,1.30561748,5.975492383,{"v":3.63e-07,"d":"3.63E-07"},{"v":1.87e-06,"d":"1.87E-06"},"ENSG00000258465","G3V3G9,Uncharacterized protein","-","PF00400,WD domain, G-beta repeat;PF04614,Pex19 protein family","IPR038322,Pex19, C-terminal domain superfamily;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR006708,Pex19 protein;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat","ENOG410XQZP,-;KOG1334,WD40 repeat protein;KOG3133,40 kDa farnesylated protein associated with peroxisomes","GO:0005829,cellular_component,cytosol;GO:0005777,cellular_component,peroxisome;GO:0005739,cellular_component,mitochondrion;GO:0005654,cellular_component,nucleoplasm","-"]
["IFT172",1.837270497,0.741055286,1.305170184,3.538716861,1.920569E-3,0.004356268,"ENSG00000138002","K7B8Z3,Intraflagellar transport 172 homolog","XP_003308981.2,intraflagellar transport protein 172 homolog isoform X1","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR011990,Tetratricopeptide-like helical domain superfamily","KOG3616,Selective LIM binding factor;ENOG410XR2C,-","GO:0031514,cellular_component,motile cilium","-"]
["ADIPOR2",17.77517249,7.190980676,1.304903976,6.214848014,{"v":1.87e-07,"d":"1.87E-07"},{"v":1.04E-6,"d":"1.04E-06"},"ENSG00000006831","H2R337,Adiponectin receptor 2","XP_016778212.1,-;XP_016778213.1,-;XP_508922.2,-;XP_009422876.1,-;XP_009422877.1,-","PF03006,Haemolysin-III related","IPR004254,AdipoR/Haemolysin-III-related","COG1272,Predicted membrane protein, hemolysin III homolog;KOG0748,Predicted membrane proteins, contain hemolysin III domain","GO:0033211,biological_process,adiponectin-activated signaling pathway;GO:0031226,cellular_component,intrinsic component of plasma membrane;GO:0042593,biological_process,glucose homeostasis;GO:0042562,molecular_function,hormone binding;GO:0097003,molecular_function,adipokinetic hormone receptor activity;GO:0055100,molecular_function,adiponectin binding;GO:0005886,cellular_component,plasma membrane;GO:0004872,-,-;GO:0046982,molecular_function,protein heterodimerization activity;GO:0016020,cellular_component,membrane;GO:0042802,molecular_function,identical protein binding;GO:0061042,biological_process,vascular wound healing;GO:0016021,cellular_component,integral component of membrane","K07297,ko04932,Non-alcoholic fatty liver disease (NAFLD);K07297,ko04211,Longevity regulating pathway;K07297,ko04152,AMPK signaling pathway;K07297,ko04920,Adipocytokine signaling pathway"]
["TOMM40",21.31221249,8.622722239,1.304515948,5.779372525,{"v":8.03e-07,"d":"8.03E-07"},{"v":3.87e-06,"d":"3.87E-06"},"ENSG00000130204","I0FI46,Mitochondrial import receptor subunit TOM40 homolog","NP_001247724.1,mitochondrial import receptor subunit TOM40 homolog","-","IPR037930,Tom40;IPR027246,Eukaryotic porin/Tom40;IPR023614,Porin domain superfamily","ENOG410XS2U,-;KOG3296,Translocase of outer mitochondrial membrane complex, subunit TOM40","GO:0055085,biological_process,transmembrane transport;GO:0030150,biological_process,protein import into mitochondrial matrix;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0008320,molecular_function,protein transmembrane transporter activity","K11518,ko05014,Amyotrophic lateral sclerosis (ALS)"]
["CEP78",1.637656174,0.661946354,1.303740594,4.115280638,0.000306909,0.000832476,"ENSG00000148019","K7AP23,Centrosomal protein 78kDa","-","PF13516,Leucine Rich repeat","IPR001611,Leucine-rich repeat;IPR026212,Centrosomal protein of 78kDa;IPR032675,Leucine-rich repeat domain superfamily","KOG4308,LRR-containing protein;ENOG410ZBX3,-","-","-"]
["LSS",3.80566135,1.539176172,1.303339924,4.334861359,0.000131472,3.87931E-4,"ENSG00000160285","B2R694,Terpene cyclase/mutase family member","NP_001001438.1,-;NP_002331.3,lanosterol synthase isoform 1","PF13243,Squalene-hopene cyclase C-terminal domain;PF13249,Squalene-hopene cyclase N-terminal domain","IPR002365,Terpene synthase, conserved site;IPR032697,Squalene cyclase, N-terminal;IPR032696,Squalene cyclase, C-terminal;IPR008930,Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid;IPR018333,Squalene cyclase","COG1657,Squalene cyclase;KOG0497,Oxidosqualene-lanosterol cyclase and related proteins","GO:0016853,molecular_function,isomerase activity;GO:0016866,molecular_function,intramolecular transferase activity","K01852,ko00100,Steroid biosynthesis"]
["DRG1",16.85708556,6.823091142,1.302810948,4.693327811,{"v":3.79E-5,"d":"3.79E-05"},0.000126355,"ENSG00000185721","I3MMF8,Uncharacterized protein","XP_005339923.1,-","PF01926,50S ribosome-binding GTPase;PF02824,TGS domain;PF16897,C-terminal region of MMR_HSR1 domain","IPR004095,TGS;IPR006074,GTP1/OBG, conserved site;IPR005225,Small GTP-binding protein domain;IPR031167,OBG-type guanine nucleotide-binding (G) domain;IPR012675,Beta-grasp domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR006073,GTP binding domain;IPR031662,GTP binding protein, second domain;IPR012676,TGS-like","COG1163,Predicted GTPase;KOG1487,GTP-binding protein DRG1 (ODN superfamily)","GO:0005525,molecular_function,GTP binding;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0016604,cellular_component,nuclear body;GO:0005844,cellular_component,polysome","-"]
["SF1",62.94363864,25.51297756,1.302635515,8.05014423,{"v":3.32e-09,"d":"3.32E-09"},{"v":2.71e-08,"d":"2.71E-08"},"ENSG00000168066","G3RAF9,Splicing factor 1","XP_018892050.1,-","PF16275,Splicing factor 1 helix-hairpin domain;PF00013,KH domain;PF00098,Zinc knuckle","IPR031150,BBP/SF1 family;IPR004088,K Homology domain, type 1;IPR004087,K Homology domain;IPR032570,Splicing factor 1, helix-hairpin domain;IPR001878,Zinc finger, CCHC-type;IPR036612,K Homology domain, type 1 superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0045131,molecular_function,pre-mRNA branch point binding;GO:0008270,molecular_function,zinc ion binding","-"]
["KCTD20",9.5912737,3.88637521,1.302080283,5.423735325,{"v":3.01E-6,"d":"3.01E-06"},{"v":1.28e-05,"d":"1.28E-05"},"ENSG00000112078","H2QSW6,Potassium channel tetramerisation domain containing 20","XP_016810839.1,-;XP_527371.1,BTB/POZ domain-containing protein KCTD20 isoform X1","PF16017,BTB/POZ domain","IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily","ENOG410ISJ3,-;ENOG410YA9I,-","GO:0005737,cellular_component,cytoplasm;GO:0042327,biological_process,positive regulation of phosphorylation","-"]
["BSPRY",32.48706562,13.16817607,1.301851909,5.762468468,{"v":8.89e-07,"d":"8.89E-07"},{"v":4.24e-06,"d":"4.24E-06"},"ENSG00000119411","H2QXQ7,Uncharacterized protein","XP_528397.2,B box and SPRY domain-containing protein isoform X1","PF13765,SPRY-associated domain;PF00622,SPRY domain","IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR003877,SPRY domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000315,B-box-type zinc finger;IPR006574,SPRY-associated","ENOG410ITF8,-;ENOG4111EI7,-","GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0008270,molecular_function,zinc ion binding;GO:0005622,cellular_component,intracellular","-"]
["GULP1",4.856643759,1.969427168,1.300933552,5.384202222,{"v":3.9e-06,"d":"3.90E-06"},{"v":1.63E-5,"d":"1.63E-05"},"ENSG00000144366","H2R2G7,GULP, engulfment adaptor PTB domain containing 1","XP_001162585.1,-;XP_001163056.1,-","PF00640,Phosphotyrosine interaction domain (PTB/PID)","IPR006020,PTB/PI domain;IPR011993,PH-like domain superfamily","KOG3536,Adaptor protein CED-6, contains PTB domain;ENOG410ZHJT,-","GO:0006911,biological_process,phagocytosis, engulfment","-"]
["ZNF503",7.733240465,3.132724901,1.300844017,4.249174429,0.000211063,0.000595901,"ENSG00000165655","A8K2P6,cDNA FLJ76083, highly similar to Homo sapiens zinc finger protein 503","-","PF12402,NocA-like zinc-finger protein 1","IPR013087,Zinc finger C2H2-type;IPR022129,Transcriptional repressor NocA-like","ENOG410IH04,-;ENOG4111EZY,-","GO:0003676,molecular_function,nucleic acid binding","-"]
["FAM92A1",2.399233584,0.971116232,1.300770999,3.734644034,1.150285E-3,0.002746927,"ENSG00000188343","K7DI16,Family with sequence similarity 92, member A1","XP_528189.3,protein FAM92A1 isoform X4","PF06730,AM92 protein","IPR027267,AH/BAR domain superfamily;IPR035590,FAM92, BAR domain;IPR009602,FAM92 protein","ENOG410IHVX,-;ENOG410Z4I5,-","-","-"]
["SAAL1",3.171291843,1.280769166,1.300577322,2.922660955,0.011232888,0.021098374,"ENSG00000166788","E9PRZ1,Protein SAAL1","-","-","IPR016024,Armadillo-type fold","ENOG4110KPS,-;ENOG410IMST,-","-","-"]
["C9orf40",4.183870201,1.689712652,1.300577322,2.922660955,0.011232888,0.021098374,"ENSG00000135045","H2QXC8,Chromosome 9 open reading frame 40","XP_520076.2,uncharacterized protein C9orf40 homolog","PF15017,Putative WW-binding domain and destruction box","IPR033461,Putative WW-binding domain and destruction box;IPR020521,Uncharacterised protein family C9orf40","ENOG410IWV7,-;ENOG41116VB,-","-","-"]
["ATP2B1",6.378630259,2.588724153,1.299805982,5.441109297,{"v":2.65E-6,"d":"2.65E-06"},{"v":1.14e-05,"d":"1.14E-05"},"ENSG00000070961","K6ZJR8,Calcium-transporting ATPase","XP_016779447.1,-","PF00122,1-E2 ATPase;PF00690,Cation transporter/ATPase, N-terminus;PF13246,Cation transport ATPase (P-type);PF00702,haloacid dehalogenase-like hydrolase;PF12424,Plasma membrane calcium transporter ATPase C terminal;PF00689,Cation transporting ATPase, C-terminus","IPR006408,P-type ATPase, subfamily IIB;IPR004014,Cation-transporting P-type ATPase, N-terminal;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR023299,P-type ATPase, cytoplasmic domain N;IPR018303,P-type ATPase, phosphorylation site;IPR023298,P-type ATPase, transmembrane domain superfamily;IPR030320,Plasma membrane calcium-transporting ATPase 1;IPR022141,Plasma membrane calcium transporting P-type ATPase, C-terminal;IPR006068,Cation-transporting P-type ATPase, C-terminal;IPR008250,P-type ATPase, A domain superfamily;IPR001757,P-type ATPase","KOG0204,Calcium transporting ATPase;ENOG410XNNC,-","GO:0016787,molecular_function,hydrolase activity;GO:0099132,biological_process,ATP hydrolysis coupled cation transmembrane transport;GO:0005388,molecular_function,calcium-transporting ATPase activity;GO:0006816,biological_process,calcium ion transport;GO:0006811,biological_process,ion transport;GO:0016020,cellular_component,membrane;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane;GO:0070588,biological_process,calcium ion transmembrane transport","-"]
["RNF10",17.87679997,7.261700441,1.299022626,6.232612977,{"v":1.92E-7,"d":"1.92E-07"},{"v":1.06E-6,"d":"1.06E-06"},"ENSG00000022840","A0A024RBP0,Ring finger protein 10, isoform CRA_a","NP_055683.3,RING finger protein 10 isoform 1","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XTFS,-;KOG2164,Predicted E3 ubiquitin ligase","-","-"]
["ESCO1",6.870537486,2.78836139,1.299007673,4.722064566,{"v":3.13e-05,"d":"3.13E-05"},1.06055E-4,"ENSG00000141446","A0A024RC19,Establishment of cohesion 1 homolog 1","XP_011524100.1,-;NP_443143.2,N-acetyltransferase ESCO1","PF13878,zinc-finger of acetyl-transferase ESCO;PF13880,SCO1/2 acetyl-transferase","IPR028005,N-acetyltransferase ESCO, zinc-finger;IPR026656,N-acetyltransferase ESCO1;IPR028009,N-acetyltransferase ESCO, acetyl-transferase domain","KOG3014,Protein involved in establishing cohesion between sister chromatids during DNA replication;ENOG410XTJX,-","GO:0034421,biological_process,post-translational protein acetylation;GO:0000785,cellular_component,chromatin;GO:0007062,biological_process,sister chromatid cohesion;GO:0006275,biological_process,regulation of DNA replication","-"]
["ENTPD7",6.623170582,2.687969197,1.298011257,4.158036348,0.000345775,0.000928046,"ENSG00000198018","F7HAL5,Ectonucleoside triphosphate diphosphohydrolase 7","XP_001106407.2,-","PF01150,A1/CD39 (nucleoside phosphatase) family","IPR000407,Nucleoside phosphatase GDA1/CD39","KOG1386,Nucleoside phosphatase;COG5371,Golgi nucleoside diphosphatase","GO:0016787,molecular_function,hydrolase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SCFD1",9.323499845,3.789746131,1.297587999,5.458276503,{"v":2.33e-06,"d":"2.33E-06"},{"v":1.02e-05,"d":"1.02E-05"},"ENSG00000092108","I0FQ93,Sec1 family domain-containing protein 1 isoform a","NP_001253452.1,sec1 family domain-containing protein 1","PF00995,Sec1 family","IPR027482,Sec1-like, domain 2;IPR036045,Sec1-like superfamily;IPR001619,Sec1-like protein","KOG1301,Vesicle trafficking protein Sly1 (Sec1 family);COG5158,Proteins involved in synaptic transmission and general secretion, Sec1 family","GO:0016192,biological_process,vesicle-mediated transport;GO:0006904,biological_process,vesicle docking involved in exocytosis","-"]
["UPK3B",7.588012161,3.079543657,1.297414189,3.90693534,0.000899355,0.002187293,"ENSG00000243566","H2QUT7,Uroplakin 3B","-","-","IPR024831,Uroplakin-3;IPR024828,Uroplakin-3b","ENOG41123W4,-;ENOG410IS9T,-","-","-"]
["HTATIP2",17.57391851,7.146038666,1.296747857,5.147374571,{"v":9.43e-06,"d":"9.43E-06"},{"v":3.6e-05,"d":"3.60E-05"},"ENSG00000109854","H2Q3A7,HIV-1 Tat interactive protein 2, 30kDa","XP_508329.2,oxidoreductase HTATIP2 isoform X1","PF13460,NAD(P)H-binding","IPR036291,NAD(P)-binding domain superfamily;IPR000534,Semialdehyde dehydrogenase, NAD-binding;IPR016040,NAD(P)-binding domain","KOG4039,Serine/threonine kinase TIP30/CC3;COG0702,Predicted nucleoside-diphosphate-sugar epimerases","GO:0051287,molecular_function,NAD binding;GO:0005737,cellular_component,cytoplasm;GO:0045765,biological_process,regulation of angiogenesis;GO:0051170,biological_process,import into nucleus;GO:0005829,cellular_component,cytosol;GO:0016620,molecular_function,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0055114,biological_process,oxidation-reduction process;GO:0005635,cellular_component,nuclear envelope","-"]
["TEX9",1.947803363,0.790502883,1.296519684,3.602189357,0.001396679,0.003260809,"ENSG00000151575","A0A0S2Z669,Testis expressed 9 isoform 1","NP_940926.1,testis-expressed protein 9 isoform 1;XP_011519832.1,-;XP_016877649.1,-;XP_005254416.1,-","-","-","-","-","-"]
["DROSHA",17.48903127,7.117624964,1.296450991,6.594344472,{"v":7.54E-8,"d":"7.54E-08"},{"v":4.54e-07,"d":"4.54E-07"},"ENSG00000113360","G3R605,Drosha ribonuclease III","XP_004059047.1,-;XP_018868890.1,-;XP_018868891.1,-","PF00636,Ribonuclease III domain;PF14622,Ribonuclease-III-like;PF00035,ouble-stranded RNA binding motif","IPR036389,Ribonuclease III, endonuclease domain superfamily;IPR000999,Ribonuclease III domain;IPR014720,Double-stranded RNA-binding domain;IPR011907,Ribonuclease III","-","GO:0003723,molecular_function,RNA binding;GO:0004525,molecular_function,ribonuclease III activity;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0006396,biological_process,RNA processing;GO:0090501,biological_process,RNA phosphodiester bond hydrolysis;GO:0016075,biological_process,rRNA catabolic process","-"]
["SND1",16.22035454,6.603678662,1.295778025,6.230317761,{"v":2.09e-07,"d":"2.09E-07"},{"v":1.14e-06,"d":"1.14E-06"},"ENSG00000197157","A0A140VK49,Staphylococcal nuclease domain containing 1, isoform CRA_b","NP_055205.2,staphylococcal nuclease domain-containing protein 1","PF00565,Staphylococcal nuclease homologue;PF00567,Tudor domain","IPR002999,Tudor domain;IPR035437,SNase-like, OB-fold superfamily;IPR016071,Staphylococcal nuclease (SNase-like), OB-fold;IPR016685,RNA-induced silencing complex, nuclease component Tudor-SN;IPR002071,Thermonuclease active site","-","GO:0005737,cellular_component,cytoplasm;GO:0016442,cellular_component,RISC complex;GO:0031047,biological_process,gene silencing by RNA;GO:0005739,cellular_component,mitochondrion;GO:0004518,molecular_function,nuclease activity;GO:0003676,molecular_function,nucleic acid binding;GO:0005829,cellular_component,cytosol;GO:0097433,cellular_component,dense body;GO:0005634,cellular_component,nucleus;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis","K15979,ko05203,Viral carcinogenesis;K15979,ko05169,Epstein-Barr virus infection"]
["IER3IP1",13.47291604,5.48429596,1.295162639,5.09933006,{"v":9.67e-06,"d":"9.67E-06"},{"v":3.69e-05,"d":"3.69E-05"},"ENSG00000134049","A0A286XD71,Uncharacterized protein","XP_003474106.1,-","-","IPR013880,Yos1-like","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["FAM46A",2.000738049,0.811986069,1.295031763,3.214243443,0.004817645,0.009921982,"ENSG00000112773","Q5TF85,Family with sequence similarity 46, member A, isoform CRA_a","-","PF07984,Nucleotidyltransferase","IPR012937,FAM46 family","KOG3852,Uncharacterized conserved protein;ENOG410XTG4,-","-","-"]
["CHD4",69.38894264,28.2770835,1.294933258,8.515310525,{"v":2.42e-09,"d":"2.42E-09"},{"v":2.04e-08,"d":"2.04E-08"},"ENSG00000111642","A0A0C4DGG9,Chromodomain-helicase-DNA-binding protein 4","-","PF08074,CHDCT2 (NUC038) domain;PF00628,PHD-finger;PF00271,Helicase conserved C-terminal domain;PF08073,CHDNT (NUC034) domain;PF00176,SNF2 family N-terminal domain;PF06465,omain of Unknown Function (DUF1087);PF06461,omain of Unknown Function (DUF1086);PF00385,Chromo (CHRromatin Organisation MOdifier) domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR023780,Chromo domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR016197,Chromo-like domain superfamily;IPR012957,CHD, C-terminal 2;IPR009462,Domain of unknown function DUF1086;IPR012958,CHD, N-terminal;IPR009463,Domain of unknown function DUF1087;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger;IPR000953,Chromo/chromo shadow domain;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR019786,Zinc finger, PHD-type, conserved site;IPR001650,Helicase, C-terminal","COG0553,Superfamily II DNA/RNA helicases, SNF2 family;KOG0383,Predicted helicase","GO:0005524,molecular_function,ATP binding;GO:0046872,molecular_function,metal ion binding;GO:0005634,cellular_component,nucleus","-"]
["PRMT3",4.126342382,1.678173854,1.294768508,4.060702452,3.97981E-4,0.00105549,"ENSG00000185238","H2Q3A8,Protein arginine methyltransferase 3","XP_003313006.1,protein arginine N-methyltransferase 3 isoform X1","PF13649,Methyltransferase domain;PF05175,Methyltransferase small domain;PF13847,Methyltransferase domain;PF08003,Protein of unknown function (DUF1698);PF06325,Ribosomal protein L11 methyltransferase (PrmA);PF08241,Methyltransferase domain","IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR025799,Protein arginine N-methyltransferase;IPR036236,Zinc finger C2H2 superfamily","KOG1499,Protein arginine N-methyltransferase PRMT1 and related enzymes;ENOG410XQYH,-","GO:0008469,molecular_function,histone-arginine N-methyltransferase activity;GO:0031397,biological_process,negative regulation of protein ubiquitination;GO:0034969,biological_process,histone arginine methylation;GO:0019919,biological_process,peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0006479,biological_process,protein methylation;GO:0035242,molecular_function,protein-arginine omega-N asymmetric methyltransferase activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005840,cellular_component,ribosome;GO:0008168,molecular_function,methyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0032259,biological_process,methylation;GO:0005829,cellular_component,cytosol;GO:0016274,molecular_function,protein-arginine N-methyltransferase activity;GO:0035246,biological_process,peptidyl-arginine N-methylation","-"]
["CD99L2",3.214489992,1.307924199,1.293415268,3.790153172,0.00108016,0.002592158,"ENSG00000102181","G3QQP8,CD99 molecule like 2","-","PF12301,CD99 antigen like protein 2","IPR022078,CD99 antigen-like protein 2","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RBM26",15.15503397,6.182939934,1.292962624,6.76685558,{"v":5.34e-08,"d":"5.34E-08"},{"v":3.35e-07,"d":"3.35E-07"},"ENSG00000139746","A0A087X0H9,RNA-binding protein 26","NP_001273560.1,RNA-binding protein 26 isoform 1;XP_011533489.1,-","PF01480,PWI domain","IPR002483,PWI domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034861,RNA-binding protein 26;IPR000504,RNA recognition motif domain;IPR000571,Zinc finger, CCCH-type;IPR035979,RNA-binding domain superfamily;IPR034859,RBM26, RNA recognition motif 1","KOG2135,Proteins containing the RNA recognition motif;ENOG41119BA,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0006397,biological_process,mRNA processing;GO:0046872,molecular_function,metal ion binding","-"]
["TMEM50A",7.311822655,2.978758592,1.292629622,4.199557005,0.000269446,0.00074161,"ENSG00000183726","Q7RU07,Cervical cancer oncogene 9","XP_011539461.1,-;NP_055128.1,transmembrane protein 50A","PF05255,Uncharacterised protein family (UPF0220)","IPR007919,Uncharacterised protein family UPF0220","KOG3393,Predicted membrane protein;ENOG410YCSG,-","GO:0005737,cellular_component,cytoplasm;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CHMP4C",50.77524007,20.72041078,1.292312802,6.078981046,{"v":3.67e-07,"d":"3.67E-07"},{"v":1.89e-06,"d":"1.89E-06"},"ENSG00000164695","H2PQP0,Charged multivesicular body protein 4C","XP_002819264.1,charged multivesicular body protein 4c","PF03357,Snf7","IPR005024,Snf7 family","ENOG410YE9I,-;KOG1656,Protein involved in glucose derepression and pre-vacuolar endosome protein sorting","GO:0030496,cellular_component,midbody;GO:0010824,biological_process,regulation of centrosome duplication;GO:0009838,biological_process,abscission;GO:0007080,biological_process,mitotic metaphase plate congression;GO:1902188,biological_process,positive regulation of viral release from host cell;GO:0090543,cellular_component,Flemming body;GO:1901673,biological_process,regulation of mitotic spindle assembly;GO:0032466,biological_process,negative regulation of cytokinesis;GO:0006997,biological_process,nucleus organization;GO:0044878,biological_process,mitotic cytokinesis checkpoint;GO:0050792,biological_process,regulation of viral process;GO:0000920,biological_process,cell separation after cytokinesis;GO:0090611,biological_process,ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:0007034,biological_process,vacuolar transport;GO:0042803,molecular_function,protein homodimerization activity","K12194,ko04144,Endocytosis"]
["HCFC2",1.192033802,0.483778894,1.292066817,2.679267685,0.021118495,0.036905358,"ENSG00000111727","Q53FE7,Host cell factor C2 variant","-","PF13415,alactose oxidase, central domain;PF13854,Kelch motif;PF01344,Kelch motif","IPR003961,Fibronectin type III;IPR036116,Fibronectin type III superfamily;IPR015915,Kelch-type beta propeller;IPR037932,Host cell factor 2;IPR013783,Immunoglobulin-like fold;IPR006652,Kelch repeat type 1","KOG4152,Host cell transcription factor HCFC1;ENOG410Y5AC,-","GO:0071339,cellular_component,MLL1 complex","-"]
["LINC01232",1.302410863,0.528574682,1.292066817,2.679267685,0.021118495,0.036905358,"ENSG00000280734","U5EQK6,Putative line-1 reverse transcriptase","-","PF08333,Protein of unknown function (DUF1725);PF00078,Reverse transcriptase (RNA-dependent DNA polymerase)","IPR013544,Domain of unknown function DUF1725;IPR000477,Reverse transcriptase domain","-","GO:0003964,molecular_function,RNA-directed DNA polymerase activity;GO:0005739,cellular_component,mitochondrion;GO:0006278,biological_process,RNA-dependent DNA biosynthetic process","-"]
["C7orf73",1.637656174,0.664631734,1.292066817,2.679267685,0.021118495,0.036905358,"ENSG00000243317","H9FYI2,Chromosome 7 open reading frame 73","-","PF15054,omain of unknown function (DUF4535)","IPR027854,Short transmembrane mitochondrial protein 1","-","-","-"]
["PADI2",2.420633165,0.985618652,1.291312072,3.45616978,0.002663264,0.005832074,"ENSG00000117115","H2PY57,Uncharacterized protein","XP_513113.3,-","PF08526,Protein-arginine deiminase (PAD) N-terminal domain;PF08527,Protein-arginine deiminase (PAD) middle domain;PF03068,Protein-arginine deiminase (PAD)","IPR013733,Protein-arginine deiminase (PAD), central domain;IPR036556,Protein-arginine deiminase, central domain superfamily;IPR038685,PAD, N-terminal domain superfamily;IPR008972,Cupredoxin;IPR004303,Protein-arginine deiminase;IPR013732,Protein-arginine deiminase (PAD) N-terminal;IPR013530,Protein-arginine deiminase, C-terminal","ENOG410ZKF3,-;ENOG410IF3F,-","GO:0030331,molecular_function,estrogen receptor binding;GO:0048096,biological_process,chromatin-mediated maintenance of transcription;GO:0036414,biological_process,histone citrullination;GO:0005737,cellular_component,cytoplasm;GO:0036413,biological_process,histone H3-R26 citrullination;GO:0035327,cellular_component,transcriptionally active chromatin;GO:0005509,molecular_function,calcium ion binding;GO:1901624,biological_process,negative regulation of lymphocyte chemotaxis;GO:0018101,biological_process,protein citrullination;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0070100,biological_process,negative regulation of chemokine-mediated signaling pathway;GO:0010848,biological_process,regulation of chromatin disassembly;GO:0030520,biological_process,intracellular estrogen receptor signaling pathway;GO:0004668,molecular_function,protein-arginine deiminase activity;GO:0005634,cellular_component,nucleus","-"]
["POLR1D",11.1633806,4.559812438,1.291153197,6.476247886,{"v":1.21e-07,"d":"1.21E-07"},{"v":6.98e-07,"d":"6.98E-07"},"ENSG00000186184","H2RA83,Polymerase","XP_003952423.1,-","PF13656,RNA polymerase Rpb3/Rpb11 dimerisation domain","IPR009025,DNA-directed RNA polymerase, RBP11-like dimerisation domain;IPR036603,RNA polymerase, RBP11-like subunit;IPR008193,DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site;IPR033898,DNA-directed RNA polymerases I and III subunit AC19","KOG3438,DNA-directed RNA polymerase, subunit L;COG1761,DNA-directed RNA polymerase, subunit L","GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding;GO:0005736,cellular_component,DNA-directed RNA polymerase I complex;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0001054,molecular_function,RNA polymerase I activity;GO:0001056,molecular_function,RNA polymerase III activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0006360,biological_process,transcription by RNA polymerase I;GO:0005666,cellular_component,DNA-directed RNA polymerase III complex;GO:0006383,biological_process,transcription by RNA polymerase III","K03020,ko00240,Pyrimidine metabolism;K03020,ko00230,Purine metabolism;K03020,ko03020,RNA polymerase;K03020,ko04623,Cytosolic DNA-sensing pathway;K03020,ko05169,Epstein-Barr virus infection"]
["RERE",14.2232496,5.810948691,1.290966267,6.859667059,{"v":4.17e-08,"d":"4.17E-08"},{"v":2.68e-07,"d":"2.68E-07"},"ENSG00000142599","A0A024R4E9,Arginine-glutamic acid dipeptide","NP_036234.3,arginine-glutamic acid dipeptide repeats protein isoform a;NP_001036146.1,-;XP_005263521.1,-;XP_016856848.1,-;XP_016856847.1,-","PF00320,ATA zinc finger;PF01448,LM2 domain;PF03154,Atrophin-1 family;PF01426,BAH domain","IPR009057,Homeobox-like domain superfamily;IPR001005,SANT/Myb domain;IPR000679,Zinc finger, GATA-type;IPR001025,Bromo adjacent homology (BAH) domain;IPR002951,Atrophin-like;IPR000949,ELM2 domain;IPR017884,SANT domain","ENOG410ZIND,-;KOG2133,Transcriptional corepressor Atrophin-1/DRPLA","GO:0048755,biological_process,branching morphogenesis of a nerve;GO:0021691,biological_process,cerebellar Purkinje cell layer maturation;GO:0006338,biological_process,chromatin remodeling;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0021942,biological_process,radial glia guided migration of Purkinje cell;GO:0048813,biological_process,dendrite morphogenesis;GO:0021549,biological_process,cerebellum development;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0001105,molecular_function,RNA polymerase II transcription coactivator activity;GO:0008270,molecular_function,zinc ion binding;GO:0000118,cellular_component,histone deacetylase complex;GO:0021930,biological_process,cerebellar granule cell precursor proliferation;GO:1903507,biological_process,negative regulation of nucleic acid-templated transcription;GO:0001106,molecular_function,RNA polymerase II transcription corepressor activity;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","K05628,ko04391,Hippo signaling pathway - fly"]
["PSD3",4.745144558,1.938454615,1.290549888,5.692792672,{"v":1.35E-6,"d":"1.35E-06"},{"v":6.23e-06,"d":"6.23E-06"},"ENSG00000156011","B3KRC4,cDNA FLJ33998 fis, clone FCBBF1000023, moderately similar to Mus musculus pleckstrin and Sec7 domain containing 3","NP_056125.3,PH and SEC7 domain-containing protein 3 isoform a;NP_996792.1,PH and SEC7 domain-containing protein 3 isoform b","PF01369,Sec7 domain;PF15410,Pleckstrin homology domain","IPR035999,Sec7 domain superfamily;IPR011993,PH-like domain superfamily;IPR001849,Pleckstrin homology domain;IPR023394,Sec7, C-terminal domain superfamily;IPR000904,Sec7 domain","COG5307,SEC7 domain proteins;KOG0932,Guanine nucleotide exchange factor EFA6","GO:0032012,biological_process,regulation of ARF protein signal transduction;GO:0005086,molecular_function,ARF guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function","K12494,ko04144,Endocytosis"]
["CFL2",4.134631308,1.688751563,1.289383389,4.44246753,0.000115286,0.000343764,"ENSG00000165410","A0A250XVI3,Cofilin-2","XP_020031164.1,-","-","IPR017904,ADF/Cofilin;IPR029006,ADF-H/Gelsolin-like domain superfamily;IPR002108,Actin-depolymerising factor homology domain","-","GO:0030042,biological_process,actin filament depolymerization;GO:0015629,cellular_component,actin cytoskeleton;GO:0003779,molecular_function,actin binding;GO:0005622,cellular_component,intracellular","K05765,ko04360,Axon guidance;K05765,ko04666,Fc gamma R-mediated phagocytosis;K05765,ko04810,Regulation of actin cytoskeleton;K05765,ko05133,Pertussis"]
["CTD-3138B18.4",14.61570803,5.975625138,1.289115137,5.375876564,{"v":4.44e-06,"d":"4.44E-06"},{"v":1.83e-05,"d":"1.83E-05"},"ENSG00000283515","A0A1B0GV72,Uncharacterized protein","-","PF01352,KRAB box","IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0005622,cellular_component,intracellular","-"]
["DPP3",9.672754221,3.954700871,1.288494579,4.804987553,{"v":3.43E-5,"d":"3.43E-05"},1.1555E-4,"ENSG00000254986","G3V180,Dipeptidyl peptidase 3","-","PF03571,Peptidase family M49","IPR005317,Dipeptidyl-peptidase 3","ENOG410XRK4,-;KOG3675,Dipeptidyl peptidase III","GO:0006508,biological_process,proteolysis;GO:0008239,molecular_function,dipeptidyl-peptidase activity;GO:0016787,molecular_function,hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0008237,molecular_function,metallopeptidase activity;GO:0004177,molecular_function,aminopeptidase activity;GO:0046872,molecular_function,metal ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016607,cellular_component,nuclear speck;GO:0005829,cellular_component,cytosol;GO:0008233,molecular_function,peptidase activity","-"]
["KIF15",7.278816185,2.975940466,1.288494579,4.804987553,{"v":3.43E-5,"d":"3.43E-05"},1.1555E-4,"ENSG00000163808","K7AKU5,Kinesin family member 15","-","PF15908,Hyaluronan mediated motility receptor C-terminal;PF00225,Kinesin motor domain","-","-","-","-"]
["RP11-106M3.5",5.493294633,2.239550361,1.287596517,3.019260182,0.010118434,0.019245475,"ENSG00000273025","G3RHG6,Uncharacterized protein","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0005737,cellular_component,cytoplasm;GO:0071625,biological_process,vocalization behavior;GO:0001505,biological_process,regulation of neurotransmitter levels;GO:0003676,molecular_function,nucleic acid binding","-"]
["HARS2",7.525145449,3.076652066,1.287564935,4.239912106,0.000258264,7.14564E-4,"ENSG00000112855","H2QRM9,Histidyl-tRNA synthetase 2, mitochondrial","XP_517980.3,-;XP_009448091.1,-","PF03129,Anticodon binding domain;PF13393,Histidyl-tRNA synthetase","IPR015807,Histidine-tRNA ligase;IPR004154,Anticodon-binding;IPR006195,Aminoacyl-tRNA synthetase, class II;IPR036621,Anticodon-binding domain superfamily;IPR033656,Histidyl-anticodon-binding;IPR004516,Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit","KOG1936,Histidyl-tRNA synthetase;COG0124,Histidyl-tRNA synthetase","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0004821,molecular_function,histidine-tRNA ligase activity;GO:0006427,biological_process,histidyl-tRNA aminoacylation;GO:0032543,biological_process,mitochondrial translation;GO:0005739,cellular_component,mitochondrion;GO:0005524,molecular_function,ATP binding","-"]
["POFUT1",17.55268737,7.189627413,1.287068767,6.329065068,{"v":1.85E-7,"d":"1.85E-07"},{"v":1.02E-6,"d":"1.02E-06"},"ENSG00000101346","K7BC39,Protein O-fucosyltransferase 1","NP_001008982.1,-","PF10250,P-fucose protein O-fucosyltransferase","IPR019378,GDP-fucose protein O-fucosyltransferase","KOG3849,GDP-fucose protein O-fucosyltransferase;ENOG410Y3JQ,-","GO:0005975,biological_process,carbohydrate metabolic process;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0007507,biological_process,heart development;GO:0007399,biological_process,nervous system development;GO:0001756,biological_process,somitogenesis;GO:0036066,biological_process,protein O-linked fucosylation;GO:0016020,cellular_component,membrane;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0046922,molecular_function,peptide-O-fucosyltransferase activity;GO:0001525,biological_process,angiogenesis;GO:0006004,biological_process,fucose metabolic process;GO:0008417,molecular_function,fucosyltransferase activity;GO:0006493,biological_process,protein O-linked glycosylation;GO:0007219,biological_process,Notch signaling pathway;GO:0008593,biological_process,regulation of Notch signaling pathway","K03691,ko00514,Other types of O-glycan biosynthesis"]
["ZNF510",3.248483663,1.32814097,1.286636719,3.84359431,0.000807467,0.001989675,"ENSG00000081386","Q6NUI8,ZNF510 protein","NP_001300988.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["RSBN1L",7.875794438,3.228435276,1.285332115,5.353457156,{"v":4.46e-06,"d":"4.46E-06"},{"v":1.84E-5,"d":"1.84E-05"},"ENSG00000187257","G3QVW6,Round spermatid basic protein 1 like","XP_004045688.1,round spermatid basic protein 1-like protein","-","IPR026306,RSBN1/Dpy-21","-","GO:0005634,cellular_component,nucleus","-"]
["RP11-426L16.10",128.202045,52.58420779,1.285201293,6.619822641,{"v":9.21e-08,"d":"9.21E-08"},{"v":5.44E-7,"d":"5.44E-07"},"ENSG00000271810","U3KQV3,Uncharacterized protein","-","PF00481,Protein phosphatase 2C;PF00071,Ras family","IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001806,Small GTPase superfamily;IPR001932,PPM-type phosphatase domain;IPR036457,PPM-type phosphatase domain superfamily;IPR003578,Small GTPase superfamily, Rho type","ENOG410XP4B,-;KOG1323,Serine/threonine phosphatase","GO:0005525,molecular_function,GTP binding;GO:0003824,molecular_function,catalytic activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005622,cellular_component,intracellular;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding","-"]
["AP006621.8",16.19046445,6.619463537,1.284784557,3.293465272,0.00525818,0.010730946,"ENSG00000255108","H2Q2V9,Uncharacterized protein","-","PF01734,Patatin-like phospholipase","IPR033562,Patatin-like phospholipase domain-containing protein;IPR033903,Patatin-like phospholipase domain-containing protein 2;IPR002641,Patatin-like phospholipase domain;IPR016035,Acyl transferase/acyl hydrolase/lysophospholipase","ENOG410XSQS,-;KOG3773,Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase","GO:0006629,biological_process,lipid metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0034389,biological_process,lipid particle organization;GO:0019433,biological_process,triglyceride catabolic process;GO:0010891,biological_process,negative regulation of sequestering of triglyceride;GO:0005737,cellular_component,cytoplasm;GO:0005811,cellular_component,lipid droplet;GO:0004806,molecular_function,triglyceride lipase activity;GO:0055088,biological_process,lipid homeostasis;GO:0044242,biological_process,cellular lipid catabolic process;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0019915,biological_process,lipid storage;GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0016042,biological_process,lipid catabolic process;GO:0010898,biological_process,positive regulation of triglyceride catabolic process","-"]
["MAP2K3",24.48042735,10.04730627,1.284050201,6.048815543,{"v":5.23e-07,"d":"5.23E-07"},{"v":2.63e-06,"d":"2.63E-06"},"ENSG00000034152","A0A0D9R5N3,Mitogen-activated protein kinase kinase 3","XP_008008875.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","-","GO:0000187,biological_process,activation of MAPK activity;GO:0019901,molecular_function,protein kinase binding;GO:0004708,molecular_function,MAP kinase kinase activity;GO:0035924,biological_process,cellular response to vascular endothelial growth factor stimulus;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0000165,biological_process,MAPK cascade;GO:0045860,biological_process,positive regulation of protein kinase activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0038066,biological_process,p38MAPK cascade;GO:0043536,biological_process,positive regulation of blood vessel endothelial cell migration;GO:0060048,biological_process,cardiac muscle contraction;GO:0042035,biological_process,regulation of cytokine biosynthetic process;GO:0004672,molecular_function,protein kinase activity;GO:0005622,cellular_component,intracellular;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0006954,biological_process,inflammatory response","K04432,ko05169,Epstein-Barr virus infection;K04432,ko04668,TNF signaling pathway;K04432,ko04620,Toll-like receptor signaling pathway;K04432,ko05014,Amyotrophic lateral sclerosis (ALS);K04432,ko04013,MAPK signaling pathway - fly;K04432,ko05164,Influenza A;K04432,ko04664,Fc epsilon RI signaling pathway;K04432,ko04750,Inflammatory mediator regulation of TRP channels;K04432,ko04015,Rap1 signaling pathway;K04432,ko04912,GnRH signaling pathway;K04432,ko04010,MAPK signaling pathway;K04432,ko05145,Toxoplasmosis"]
["RACGAP1",9.790534183,4.016378311,1.283869492,4.992686518,{"v":1.6e-05,"d":"1.60E-05"},{"v":5.81e-05,"d":"5.81E-05"},"ENSG00000161800","A0A024R136,Rac GTPase activating protein 1, isoform CRA_a","NP_001306931.1,-;NP_037409.2,rac GTPase-activating protein 1 isoform a;NP_001306928.1,-;XP_016874709.1,-;NP_001306932.1,-;NP_001306933.1,-;XP_006719422.1,-;NP_001306929.1,-;NP_001119576.1,-;XP_011536540.1,-;NP_001306930.1,-;NP_001119575.1,-","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR000198,Rho GTPase-activating protein domain","ENOG410XPK0,-;KOG3564,GTPase-activating protein","GO:0035556,biological_process,intracellular signal transduction;GO:0045995,biological_process,regulation of embryonic development;GO:0046872,molecular_function,metal ion binding;GO:0007405,biological_process,neuroblast proliferation;GO:0007165,biological_process,signal transduction;GO:0005654,cellular_component,nucleoplasm","-"]
["ABHD13",4.937818682,2.025645127,1.282789969,4.27916544,0.000202944,0.000575401,"ENSG00000139826","F7H550,Abhydrolase domain containing 13","NP_001177833.1,-;XP_014976825.1,-","PF00561,alpha/beta hydrolase fold;PF12146,Serine aminopeptidase, S33;PF05448,Acetyl xylan esterase (AXE1)","IPR022742,Serine aminopeptidase, S33;IPR029058,Alpha/Beta hydrolase fold","COG1073,Hydrolases of the alpha/beta superfamily;KOG4391,Predicted alpha/beta hydrolase BEM46","GO:0016787,molecular_function,hydrolase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["BRWD3",10.1763289,4.181619513,1.282532663,6.524061672,{"v":1.22e-07,"d":"1.22E-07"},{"v":7e-07,"d":"7.00E-07"},"ENSG00000165288","K7CWG3,Bromodomain and WD repeat domain containing 3","XP_016798758.1,-","PF00439,Bromodomain;PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR036427,Bromodomain-like superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001487,Bromodomain;IPR001680,WD40 repeat","COG2319,FOG: WD40 repeat;ENOG410IRXR,-","GO:0007010,biological_process,cytoskeleton organization;GO:0008360,biological_process,regulation of cell shape","-"]
["MFF",4.671980094,1.918029922,1.281932495,4.399207041,1.74236E-4,0.000500087,"ENSG00000168958","A0A024R491,Chromosome 2 open reading frame 33, isoform CRA_a","XP_011509802.1,-;NP_064579.3,mitochondrial fission factor isoform a;NP_001263990.1,-","PF05644,Mitochondrial and peroxisomal fission factor Mff","IPR008518,FATE/Miff/Tango-11","ENOG410XSQR,-;ENOG410III7,-","GO:0005741,cellular_component,mitochondrial outer membrane;GO:0005777,cellular_component,peroxisome;GO:0000266,biological_process,mitochondrial fission;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["HDAC1",57.10308313,23.48130669,1.281741832,7.327238325,{"v":1.85E-8,"d":"1.85E-08"},{"v":1.29E-7,"d":"1.29E-07"},"ENSG00000116478","G3R7V7,Histone deacetylase","XP_004025419.1,histone deacetylase 1 isoform X1","PF00850,Histone deacetylase domain","IPR023696,Ureohydrolase domain superfamily;IPR003084,Histone deacetylase;IPR037138,Histone deacetylase domain superfamily;IPR000286,Histone deacetylase superfamily;IPR023801,Histone deacetylase domain","-","GO:0032041,molecular_function,NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0051059,molecular_function,NF-kappaB binding;GO:0042733,biological_process,embryonic digit morphogenesis;GO:0032991,cellular_component,protein-containing complex;GO:0001103,molecular_function,RNA polymerase II repressing transcription factor binding;GO:0048714,biological_process,positive regulation of oligodendrocyte differentiation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003714,molecular_function,transcription corepressor activity;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0090090,biological_process,negative regulation of canonical Wnt signaling pathway;GO:0000118,cellular_component,histone deacetylase complex;GO:0001046,molecular_function,core promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0060789,biological_process,hair follicle placode formation;GO:0000785,cellular_component,chromatin;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0042826,molecular_function,histone deacetylase binding;GO:0016787,molecular_function,hydrolase activity;GO:0032922,biological_process,circadian regulation of gene expression;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0070932,biological_process,histone H3 deacetylation;GO:0005829,cellular_component,cytosol;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0033558,molecular_function,protein deacetylase activity;GO:0006476,biological_process,protein deacetylation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0047485,molecular_function,protein N-terminus binding;GO:0035851,molecular_function,Krueppel-associated box domain binding;GO:0061029,biological_process,eyelid development in camera-type eye;GO:0010629,biological_process,negative regulation of gene expression;GO:0030182,biological_process,neuron differentiation;GO:0006325,biological_process,chromatin organization;GO:0016575,biological_process,histone deacetylation;GO:0000790,cellular_component,nuclear chromatin;GO:0070933,biological_process,histone H4 deacetylation;GO:0001047,molecular_function,core promoter binding;GO:0019213,molecular_function,deacetylase activity;GO:0007623,biological_process,circadian rhythm;GO:0033613,molecular_function,activating transcription factor binding;GO:0070491,molecular_function,repressing transcription factor binding;GO:0060766,biological_process,negative regulation of androgen receptor signaling pathway;GO:0003677,molecular_function,DNA binding;GO:0043124,biological_process,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0000792,cellular_component,heterochromatin;GO:0043922,biological_process,negative regulation by host of viral transcription;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0061198,biological_process,fungiform papilla formation;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0001085,molecular_function,RNA polymerase II transcription factor binding;GO:0007492,biological_process,endoderm development;GO:0016581,cellular_component,NuRD complex;GO:0001106,molecular_function,RNA polymerase II transcription corepressor activity;GO:0042475,biological_process,odontogenesis of dentin-containing tooth;GO:0005654,cellular_component,nucleoplasm;GO:0016580,cellular_component,Sin3 complex;GO:0019899,molecular_function,enzyme binding;GO:0005667,cellular_component,transcription factor complex;GO:0004407,molecular_function,histone deacetylase activity;GO:0017053,cellular_component,transcriptional repressor complex;GO:0043025,cellular_component,neuronal cell body;GO:0003682,molecular_function,chromatin binding;GO:0046872,molecular_function,metal ion binding;GO:0006346,biological_process,methylation-dependent chromatin silencing;GO:2001243,biological_process,negative regulation of intrinsic apoptotic signaling pathway;GO:0021766,biological_process,hippocampus development;GO:0002039,molecular_function,p53 binding;GO:0008134,molecular_function,transcription factor binding;GO:0010870,biological_process,positive regulation of receptor biosynthetic process;GO:0009913,biological_process,epidermal cell differentiation","K06067,ko04213,Longevity regulating pathway - multiple species;K06067,ko05200,Pathways in cancer;K06067,ko05220,Chronic myeloid leukemia;K06067,ko05169,Epstein-Barr virus infection;K06067,ko04919,Thyroid hormone signaling pathway;K06067,ko04330,Notch signaling pathway;K06067,ko05034,Alcoholism;K06067,ko04110,Cell cycle;K06067,ko05016,Huntington's disease;K06067,ko05203,Viral carcinogenesis;K06067,ko05202,Transcriptional misregulation in cancer"]
["SQSTM1",15.29498976,6.292987513,1.280635677,6.383986421,{"v":1.84e-07,"d":"1.84E-07"},{"v":1.02E-6,"d":"1.02E-06"},"ENSG00000161011","H2R540,Sequestosome 1","XP_001153075.1,sequestosome-1 isoform X1","PF00569,Zinc finger, ZZ type;PF16577,UBA domain;PF00564,PB1 domain","IPR033741,Sequestosome-1, UBA domain;IPR009060,UBA-like superfamily;IPR000270,PB1 domain;IPR015940,Ubiquitin-associated domain;IPR034866,Sequestosome-1, PB1 domain;IPR000433,Zinc finger, ZZ-type","ENOG410XYAV,-;KOG4582,Uncharacterized conserved protein, contains ZZ-type Zn-finger","GO:0019901,molecular_function,protein kinase binding;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0097225,cellular_component,sperm midpiece;GO:1903078,biological_process,positive regulation of protein localization to plasma membrane;GO:0044754,cellular_component,autolysosome;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0000423,biological_process,mitophagy;GO:0044130,biological_process,negative regulation of growth of symbiont in host;GO:0016236,biological_process,macroautophagy;GO:0000407,cellular_component,phagophore assembly site;GO:0035973,biological_process,aggrephagy;GO:0005737,cellular_component,cytoplasm;GO:0035255,molecular_function,ionotropic glutamate receptor binding;GO:0042169,molecular_function,SH2 domain binding;GO:0007032,biological_process,endosome organization;GO:0005776,cellular_component,autophagosome;GO:0000932,cellular_component,P-body;GO:0044753,cellular_component,amphisome;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0016605,cellular_component,PML body;GO:0016234,cellular_component,inclusion body;GO:0070530,molecular_function,K63-linked polyubiquitin modification-dependent protein binding;GO:0098780,biological_process,response to mitochondrial depolarisation;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:1905719,biological_process,protein localization to perinuclear region of cytoplasm;GO:0061635,biological_process,regulation of protein complex stability;GO:0043130,molecular_function,ubiquitin binding;GO:0016235,cellular_component,aggresome;GO:0008270,molecular_function,zinc ion binding;GO:1900273,biological_process,positive regulation of long-term synaptic potentiation;GO:0019899,molecular_function,enzyme binding;GO:0006914,biological_process,autophagy;GO:0046872,molecular_function,metal ion binding;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0043122,biological_process,regulation of I-kappaB kinase/NF-kappaB signaling;GO:0005080,molecular_function,protein kinase C binding","K14381,ko04380,Osteoclast differentiation"]
["RBAK",5.151793382,2.118513654,1.280042656,4.708781544,{"v":4.41e-05,"d":"4.41E-05"},1.45239E-4,"ENSG00000146587","H2RE22,Uncharacterized protein","XP_009450822.1,-;XP_016812537.1,-;XP_009450821.1,-;XP_016812539.1,-;XP_009450820.1,-;XP_009450819.1,RB-associated KRAB zinc finger protein;XP_016812536.1,-;XP_016812538.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["DHFR",22.56652322,9.289619105,1.279779917,6.152211926,{"v":3.59e-07,"d":"3.59E-07"},{"v":1.85e-06,"d":"1.85E-06"},"ENSG00000228716","S5WD14,Trimethoprim resistant protein","-","PF00186,ihydrofolate reductase","IPR017925,Dihydrofolate reductase conserved site;IPR001796,Dihydrofolate reductase domain;IPR024072,Dihydrofolate reductase-like domain superfamily","-","GO:0055114,biological_process,oxidation-reduction process;GO:0004146,molecular_function,dihydrofolate reductase activity;GO:0046654,biological_process,tetrahydrofolate biosynthetic process","-"]
["AHNAK",13.07769205,5.386709603,1.2793533,7.496796257,{"v":1.55E-8,"d":"1.55E-08"},{"v":1.1e-07,"d":"1.10E-07"},"ENSG00000124942","H2QPH0,Uncharacterized protein","XP_003313140.1,-;XP_003313139.1,neuroblast differentiation-associated protein AHNAK isoform X1;XP_003313141.1,-;XP_016776545.1,-","-","IPR036034,PDZ superfamily;IPR001478,PDZ domain","ENOG410IGIF,-;ENOG410XQS3,-","GO:0045121,cellular_component,membrane raft;GO:0070062,cellular_component,extracellular exosome;GO:1901385,biological_process,regulation of voltage-gated calcium channel activity;GO:0015629,cellular_component,actin cytoskeleton;GO:0045296,molecular_function,cadherin binding;GO:0044291,cellular_component,cell-cell contact zone;GO:0097493,molecular_function,structural molecule activity conferring elasticity;GO:0005737,cellular_component,cytoplasm;GO:0051259,biological_process,protein complex oligomerization;GO:0005886,cellular_component,plasma membrane;GO:0042383,cellular_component,sarcolemma;GO:0005829,cellular_component,cytosol;GO:0043034,cellular_component,costamere;GO:0044548,molecular_function,S100 protein binding;GO:0031982,cellular_component,vesicle;GO:0005634,cellular_component,nucleus;GO:0043484,biological_process,regulation of RNA splicing","-"]
["PTDSS1",21.72788621,8.952837578,1.278613076,6.606885167,{"v":1.12E-7,"d":"1.12E-07"},{"v":6.49e-07,"d":"6.49E-07"},"ENSG00000156471","H2QWG7,Phosphatidylserine synthase 1","XP_519868.2,-","PF03034,Phosphatidyl serine synthase","IPR004277,Phosphatidyl serine synthase","KOG2735,Phosphatidylserine synthase;ENOG410XS7H,-","GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0006659,biological_process,phosphatidylserine biosynthetic process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K08729,ko00564,Glycerophospholipid metabolism"]
["PPP1R15B",13.53799948,5.579117393,1.277905506,5.668044182,{"v":1.89e-06,"d":"1.89E-06"},{"v":8.43e-06,"d":"8.43E-06"},"ENSG00000158615","H2Q0Y9,Protein phosphatase 1, regulatory","XP_001159260.1,protein phosphatase 1 regulatory subunit 15B isoform X1","PF10488,Phosphatase-1 catalytic subunit binding region;PF10472,eIF2-alpha phosphatase phosphorylation constitutive repressor","IPR019523,Protein phosphatase 1, regulatory subunit 15A/B, C-terminal;IPR019512,Protein phosphatase 1, regulatory subunit 15B, N-terminal","ENOG410IJ9C,-;ENOG4111TVA,-","GO:0006983,biological_process,ER overload response;GO:0019888,molecular_function,protein phosphatase regulator activity;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0070262,biological_process,peptidyl-serine dephosphorylation;GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0000164,cellular_component,protein phosphatase type 1 complex;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0006979,biological_process,response to oxidative stress;GO:1903912,biological_process,negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0042542,biological_process,response to hydrogen peroxide","-"]
["TNK1",2.276172377,0.933755932,1.277421217,2.793190915,0.022219062,0.038602113,"ENSG00000174292","G1RE00,Tyrosine kinase non receptor 1","XP_003274658.1,non-receptor tyrosine-protein kinase TNK1 isoform X2","PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR011009,Protein kinase-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XPRC,-;KOG0199,ACK and related non-receptor tyrosine kinases","GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0046580,biological_process,negative regulation of Ras protein signal transduction;GO:0030308,biological_process,negative regulation of cell growth;GO:0005737,cellular_component,cytoplasm;GO:0046777,biological_process,protein autophosphorylation;GO:0004715,molecular_function,non-membrane spanning protein tyrosine kinase activity;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding","-"]
["SLC10A7",1.313896422,0.539000732,1.277421217,2.793190915,0.022219062,0.038602113,"ENSG00000120519","G7MS31,Solute carrier family 10 member 7","XP_001098117.2,-","PF13593,SBF-like CPA transporter family (DUF4137)","IPR016833,Putative sodium bile acid cotransporter","KOG4821,Predicted Na+-dependent cotransporter;COG0385,Predicted Na+-dependent transporter","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["VPS37B",24.01327187,9.907512198,1.276742871,6.670558059,{"v":9.4e-08,"d":"9.40E-08"},{"v":5.55e-07,"d":"5.55E-07"},"ENSG00000139722","G3QQI9,VPS37B, ESCRT-I subunit","XP_004054120.1,-","PF07200,Modifier of rudimentary (Mod(r)) protein","IPR029012,Helix hairpin bin domain superfamily;IPR009851,Modifier of rudimentary, Modr;IPR037859,Vacuolar protein sorting-associated protein 37;IPR037202,ESCRT assembly domain","-","GO:0030496,cellular_component,midbody;GO:1903774,biological_process,positive regulation of viral budding via host ESCRT complex;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0000813,cellular_component,ESCRT I complex;GO:0005768,cellular_component,endosome;GO:1902188,biological_process,positive regulation of viral release from host cell;GO:0005886,cellular_component,plasma membrane;GO:0048306,molecular_function,calcium-dependent protein binding;GO:0010008,cellular_component,endosome membrane;GO:0032509,biological_process,endosome transport via multivesicular body sorting pathway","K12185,ko04144,Endocytosis"]
["PCGF6",4.271192816,1.755563808,1.276362408,3.109733973,0.006944527,0.013746406,"ENSG00000156374","H2NBH2,Polycomb group ring finger 6","XP_002821159.1,polycomb group RING finger protein 6","PF13923,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR029071,Ubiquitin-like domain superfamily;IPR017907,Zinc finger, RING-type, conserved site;IPR038037,Polycomb group RING finger protein 6;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XPCN,-;KOG2660,Locus-specific chromosome binding proteins","GO:0003677,molecular_function,DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0035102,cellular_component,PRC1 complex;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0031519,cellular_component,PcG protein complex;GO:0005634,cellular_component,nucleus;GO:0036353,biological_process,histone H2A-K119 monoubiquitination","K11470,ko04550,Signaling pathways regulating pluripotency of stem cells"]
["ERCC6L",2.557430529,1.051165956,1.276362408,3.109733973,0.006944527,0.013746406,"ENSG00000186871","K7BS39,Excision repair cross-complementing rodent repair deficiency, complementation group 6-like","XP_003317563.2,DNA excision repair protein ERCC-6-like","PF00271,Helicase conserved C-terminal domain;PF00176,SNF2 family N-terminal domain","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR013026,Tetratricopeptide repeat-containing domain;IPR001650,Helicase, C-terminal","KOG0387,Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain);ENOG410XP4Z,-","GO:0005524,molecular_function,ATP binding;GO:0015616,molecular_function,DNA translocase activity","-"]
["RGMB",2.028965415,0.834999036,1.275674585,3.368527499,0.004809394,0.009908792,"ENSG00000174136","J3KNF6,RGM domain family member B","XP_016864879.1,-;NP_001012779.2,RGM domain family member B;XP_016864880.1,-;XP_011541647.1,-","PF06534,Repulsive guidance molecule (RGM) C-terminus;PF06535,Repulsive guidance molecule (RGM) N-terminus","IPR010536,Repulsive guidance molecule, N-terminal;IPR009496,Repulsive guidance molecule, C-terminal;IPR033608,RGM domain family member B;IPR016123,Mog1/PsbP, alpha/beta/alpha sandwich","ENOG410ZT7E,-;ENOG410IFAH,-","GO:0007155,biological_process,cell adhesion;GO:0005793,cellular_component,endoplasmic reticulum-Golgi intermediate compartment;GO:0030509,biological_process,BMP signaling pathway;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0046658,cellular_component,anchored component of plasma membrane;GO:0042802,molecular_function,identical protein binding;GO:0007165,biological_process,signal transduction","-"]
["TRIM35",3.726828235,1.5350829,1.275191836,3.587491178,0.00178899,0.004094755,"ENSG00000104228","H2QVX7,Tripartite motif containing 35","XP_519674.2,-","PF00643,B-box zinc finger;PF13920,Zinc finger, C3HC4 type (RING finger);PF13765,SPRY-associated domain;PF00622,SPRY domain","IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR003877,SPRY domain;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000315,B-box-type zinc finger;IPR006574,SPRY-associated","ENOG410YB4K,-;ENOG410ITFW,-","GO:0045087,biological_process,innate immune response;GO:0045930,biological_process,negative regulation of mitotic cell cycle;GO:0046872,molecular_function,metal ion binding;GO:1902187,biological_process,negative regulation of viral release from host cell;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0005622,cellular_component,intracellular;GO:0008270,molecular_function,zinc ion binding","-"]
["PSMC2",28.45763188,11.76180258,1.274006729,6.170760974,{"v":4.39E-7,"d":"4.39E-07"},{"v":2.23e-06,"d":"2.23E-06"},"ENSG00000161057","A0A091EPH4,26S protease regulatory subunit 7","XP_010635339.1,-","PF00004,ATPase family associated with various cellular activities (AAA)","IPR035245,26S Proteasome regulatory subunit 7;IPR003960,ATPase, AAA-type, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR005937,26S proteasome regulatory subunit P45-like;IPR003593,AAA+ ATPase domain;IPR003959,ATPase, AAA-type, core","-","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:1901800,biological_process,positive regulation of proteasomal protein catabolic process;GO:0005737,cellular_component,cytoplasm;GO:0030163,biological_process,protein catabolic process;GO:0036402,molecular_function,proteasome-activating ATPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0008233,molecular_function,peptidase activity","-"]
["ERVK3-1",6.94936121,2.870235235,1.273693026,4.672944531,{"v":5.36e-05,"d":"5.36E-05"},0.000172675,"ENSG00000142396","A0A0U1RQV1,Uncharacterized protein","-","PF15695,Rec (regulator of expression encoded by corf) of HERV-K-113","-","-","-","-"]
["LDLRAP1",9.987669627,4.128425841,1.27325027,5.284019777,{"v":7.71e-06,"d":"7.71E-06"},{"v":3.01E-5,"d":"3.01E-05"},"ENSG00000157978","B3KR97,cDNA FLJ33900 fis, clone CTONG2008262, highly similar to Low density lipoprotein receptor adapter protein 1","NP_056442.2,low density lipoprotein receptor adapter protein 1","PF00640,Phosphotyrosine interaction domain (PTB/PID)","IPR006020,PTB/PI domain;IPR011993,PH-like domain superfamily","KOG3536,Adaptor protein CED-6, contains PTB domain;ENOG410ZHJT,-","-","K12474,ko04144,Endocytosis"]
["PIK3CA",7.493960594,3.098719223,1.273058468,5.664637442,{"v":2.11e-06,"d":"2.11E-06"},{"v":9.32e-06,"d":"9.32E-06"},"ENSG00000121879","A0A096MY63,Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha","XP_009199592.1,-;XP_003894855.1,-;XP_009199591.1,-","PF00454,Phosphatidylinositol 3- and 4-kinase;PF00792,Phosphoinositide 3-kinase C2;PF02192,PI3-kinase family, p85-binding domain;PF00794,PI3-kinase family, ras-binding domain;PF00613,Phosphoinositide 3-kinase family, accessory domain (PIK domain)","IPR003113,Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain;IPR018936,Phosphatidylinositol 3/4-kinase, conserved site;IPR000341,Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain;IPR037704,PI3Kalpha, catalytic domain;IPR036940,Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily;IPR000403,Phosphatidylinositol 3-/4-kinase, catalytic domain;IPR015433,Phosphatidylinositol kinase;IPR011009,Protein kinase-like domain superfamily;IPR008290,Phosphatidylinositol 3-kinase, Vps34 type;IPR016024,Armadillo-type fold;IPR029071,Ubiquitin-like domain superfamily;IPR001263,Phosphoinositide 3-kinase, accessory (PIK) domain;IPR002420,Phosphatidylinositol 3-kinase, C2 domain","-","GO:2000270,biological_process,negative regulation of fibroblast apoptotic process;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:0036092,biological_process,phosphatidylinositol-3-phosphate biosynthetic process;GO:2000653,biological_process,regulation of genetic imprinting;GO:0044029,biological_process,hypomethylation of CpG island;GO:0016310,biological_process,phosphorylation;GO:2000811,biological_process,negative regulation of anoikis;GO:0016301,molecular_function,kinase activity;GO:0030027,cellular_component,lamellipodium;GO:0005942,cellular_component,phosphatidylinositol 3-kinase complex;GO:0046854,biological_process,phosphatidylinositol phosphorylation;GO:0014065,biological_process,phosphatidylinositol 3-kinase signaling;GO:0048015,biological_process,phosphatidylinositol-mediated signaling;GO:0043457,biological_process,regulation of cellular respiration;GO:0006006,biological_process,glucose metabolic process;GO:0043560,molecular_function,insulin receptor substrate binding;GO:0016303,molecular_function,1-phosphatidylinositol-3-kinase activity;GO:0032147,biological_process,activation of protein kinase activity;GO:0016740,molecular_function,transferase activity;GO:0043491,biological_process,protein kinase B signaling;GO:0010468,biological_process,regulation of gene expression;GO:0006468,biological_process,protein phosphorylation;GO:0097009,biological_process,energy homeostasis;GO:0071333,biological_process,cellular response to glucose stimulus;GO:0030295,molecular_function,protein kinase activator activity;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0001889,biological_process,liver development;GO:0035004,molecular_function,phosphatidylinositol 3-kinase activity;GO:0005622,cellular_component,intracellular;GO:0060612,biological_process,adipose tissue development;GO:0005943,cellular_component,phosphatidylinositol 3-kinase complex, class IA;GO:0040014,biological_process,regulation of multicellular organism growth","-"]
["YWHAG",106.0022089,43.86321318,1.272833976,8.139109019,{"v":6.77e-09,"d":"6.77E-09"},{"v":5.18e-08,"d":"5.18E-08"},"ENSG00000170027","A8IP69,14-3-3 protein gamma subtype","NP_061359.2,-","PF00244,14-3-3 protein","IPR023410,14-3-3 domain;IPR000308,14-3-3 protein;IPR036815,14-3-3 domain superfamily;IPR023409,14-3-3 protein, conserved site","KOG0841,Multifunctional chaperone (14-3-3 family);COG5040,14-3-3 family protein","GO:0043209,cellular_component,myelin sheath;GO:0006605,biological_process,protein targeting;GO:0030971,molecular_function,receptor tyrosine kinase binding;GO:0031982,cellular_component,vesicle;GO:0005159,molecular_function,insulin-like growth factor receptor binding;GO:0048167,biological_process,regulation of synaptic plasticity;GO:0004497,molecular_function,monooxygenase activity;GO:0019904,molecular_function,protein domain specific binding;GO:0045664,biological_process,regulation of neuron differentiation;GO:0005622,cellular_component,intracellular;GO:0055114,biological_process,oxidation-reduction process;GO:0032869,biological_process,cellular response to insulin stimulus;GO:0042802,molecular_function,identical protein binding;GO:0005080,molecular_function,protein kinase C binding","K16198,ko04114,Oocyte meiosis;K16198,ko05203,Viral carcinogenesis;K16198,ko04151,PI3K-Akt signaling pathway;K16198,ko04390,Hippo signaling pathway;K16198,ko05169,Epstein-Barr virus infection;K16198,ko04110,Cell cycle"]
["DCTN2",25.3395934,10.48958148,1.271778727,6.256265456,{"v":3.35e-07,"d":"3.35E-07"},{"v":1.74e-06,"d":"1.74E-06"},"ENSG00000175203","V9HW58,Epididymis secretory protein Li 77","NP_006391.1,dynactin subunit 2 isoform 1","PF04912,ynamitin","IPR028133,Dynamitin","KOG3958,Putative dynamitin;ENOG410XSZK,-","GO:0005869,cellular_component,dynactin complex;GO:0032402,biological_process,melanosome transport;GO:0030426,cellular_component,growth cone;GO:0007017,biological_process,microtubule-based process;GO:0005813,cellular_component,centrosome;GO:0005829,cellular_component,cytosol","-"]
["LRRC37A16P",7.469257519,3.091974842,1.269974238,4.390879258,0.000210555,0.000594988,"ENSG00000267023","A0A096P686,Uncharacterized protein","-","PF14914,LRRC37A/B like protein 1 C-terminal domain;PF13855,Leucine rich repeat;PF15779,Leucine-rich repeat-containing protein 37 family","IPR015753,Leucine-rich repeat-containing protein 37;IPR029423,LRRC37A/B like protein 1, C-terminal","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZNF639",4.154427385,1.719767316,1.269974238,4.390879258,0.000210555,0.000594988,"ENSG00000121864","H9FVB6,Zinc finger protein 639","XP_014987055.1,-","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["PRNP",72.87885904,30.22640689,1.269353729,7.208325379,{"v":3.33E-8,"d":"3.33E-08"},{"v":2.19e-07,"d":"2.19E-07"},"ENSG00000171867","Q53YK7,Major prion protein","NP_001073592.1,-;NP_001073590.1,-;NP_898902.1,-;NP_001073591.1,-;NP_000302.1,major prion protein Prp preproprotein","PF00377,Prion/Doppel alpha-helical domain;PF11587,Major prion protein bPrPp - N terminal","IPR025860,Major prion protein N-terminal domain;IPR022416,Prion/Doppel protein, beta-ribbon domain;IPR000817,Prion protein;IPR036924,Prion/Doppel beta-ribbon domain superfamily","ENOG410YXUU,-;ENOG410IJMM,-","GO:0090314,biological_process,positive regulation of protein targeting to membrane;GO:1901216,biological_process,positive regulation of neuron death;GO:0050730,biological_process,regulation of peptidyl-tyrosine phosphorylation;GO:0005783,cellular_component,endoplasmic reticulum;GO:0051260,biological_process,protein homooligomerization;GO:0005886,cellular_component,plasma membrane;GO:1901379,biological_process,regulation of potassium ion transmembrane transport;GO:0043433,biological_process,negative regulation of DNA binding transcription factor activity;GO:1903078,biological_process,positive regulation of protein localization to plasma membrane;GO:0046688,biological_process,response to copper ion;GO:0009986,cellular_component,cell surface;GO:1990535,biological_process,neuron projection maintenance;GO:0032700,biological_process,negative regulation of interleukin-17 production;GO:0050860,biological_process,negative regulation of T cell receptor signaling pathway;GO:0030425,cellular_component,dendrite;GO:0016020,cellular_component,membrane;GO:1904646,biological_process,cellular response to amyloid-beta;GO:0005737,cellular_component,cytoplasm;GO:0090647,biological_process,modulation of age-related behavioral decline;GO:1904645,biological_process,response to amyloid-beta;GO:0002020,molecular_function,protease binding;GO:0044877,molecular_function,protein-containing complex binding;GO:1902430,biological_process,negative regulation of amyloid-beta formation;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0007611,biological_process,learning or memory;GO:1905664,biological_process,regulation of calcium ion import across plasma membrane;GO:0010942,biological_process,positive regulation of cell death;GO:0051087,molecular_function,chaperone binding;GO:0043008,molecular_function,ATP-dependent protein binding;GO:0035690,biological_process,cellular response to drug;GO:1903135,molecular_function,cupric ion binding;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0032147,biological_process,activation of protein kinase activity;GO:0031802,molecular_function,type 5 metabotropic glutamate receptor binding;GO:0032703,biological_process,negative regulation of interleukin-2 production;GO:0046007,biological_process,negative regulation of activated T cell proliferation;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0035584,biological_process,calcium-mediated signaling using intracellular calcium source;GO:0014069,cellular_component,postsynaptic density;GO:0004871,molecular_function,signal transducer activity;GO:0006979,biological_process,response to oxidative stress;GO:0001540,molecular_function,amyloid-beta binding;GO:0031965,cellular_component,nuclear membrane;GO:0005507,molecular_function,copper ion binding;GO:1902951,biological_process,negative regulation of dendritic spine maintenance;GO:0004872,-,-;GO:1900272,biological_process,negative regulation of long-term synaptic potentiation;GO:0045121,cellular_component,membrane raft;GO:0005521,molecular_function,lamin binding;GO:0005539,molecular_function,glycosaminoglycan binding;GO:0032880,biological_process,regulation of protein localization;GO:1902992,biological_process,negative regulation of amyloid precursor protein catabolic process;GO:0044325,molecular_function,ion channel binding;GO:0046872,molecular_function,metal ion binding;GO:0046686,biological_process,response to cadmium ion;GO:0050731,biological_process,positive regulation of peptidyl-tyrosine phosphorylation;GO:0043086,biological_process,negative regulation of catalytic activity;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0032689,biological_process,negative regulation of interferon-gamma production;GO:0005794,cellular_component,Golgi apparatus;GO:0070885,biological_process,negative regulation of calcineurin-NFAT signaling cascade","K05634,ko05020,Prion diseases"]
["TBRG4",3.273619097,1.3551478,1.268747025,3.831227364,0.00101524,0.002446946,"ENSG00000136270","B4DU42,cDNA FLJ56153, highly similar to Homo sapiens transforming growth factor beta regulator 4","NP_001248763.1,protein TBRG4 isoform 3","PF08373,RAP domain;PF06743,AST kinase-like protein, subdomain 1;PF08368,AST kinase-like protein, subdomain 2","IPR013579,FAST kinase-like protein, subdomain 2;IPR010622,FAST kinase leucine-rich;IPR013584,RAP domain","ENOG410IEJA,-;ENOG4111EYX,-","GO:0006468,biological_process,protein phosphorylation;GO:0004672,molecular_function,protein kinase activity;GO:0005739,cellular_component,mitochondrion","-"]
["RNF40",38.84255328,16.12447737,1.268109567,7.493336287,{"v":2E-8,"d":"2.00E-08"},{"v":1.38e-07,"d":"1.38E-07"},"ENSG00000103549","A0A024QZG0,Ring finger protein 40, isoform CRA_a","NP_001273501.1,-;NP_055586.1,E3 ubiquitin-protein ligase BRE1B isoform 1","PF13920,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR013956,E3 ubiquitin ligase Bre1;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG0978,E3 ubiquitin ligase involved in syntaxin degradation;ENOG410Y5C6,-","GO:1901800,biological_process,positive regulation of proteasomal protein catabolic process;GO:0031624,molecular_function,ubiquitin conjugating enzyme binding;GO:1902916,biological_process,positive regulation of protein polyubiquitination;GO:0017075,molecular_function,syntaxin-1 binding;GO:2001168,biological_process,positive regulation of histone H2B ubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0019898,cellular_component,extrinsic component of membrane;GO:0010390,biological_process,histone monoubiquitination;GO:0005829,cellular_component,cytosol;GO:0043434,biological_process,response to peptide hormone;GO:0043679,cellular_component,axon terminus;GO:0043005,cellular_component,neuron projection;GO:0005654,cellular_component,nucleoplasm","-"]
["PFN1",244.2720367,101.4157115,1.268063446,8.427760761,{"v":5.24e-09,"d":"5.24E-09"},{"v":4.09e-08,"d":"4.09E-08"},"ENSG00000108518","I3L3D5,Profilin","-","PF00235,Profilin","IPR005455,Profilin;IPR036140,Profilin superfamily;IPR005454,Profilin1/2/3, vertebrate","KOG1755,Profilin;ENOG41126PD,-","GO:0030036,biological_process,actin cytoskeleton organization;GO:0003779,molecular_function,actin binding","-"]
["C12orf4",2.88471527,1.194157119,1.267522331,3.439846651,0.003429501,0.00731006,"ENSG00000047621","H2Q588,Chromosome 12 open reading frame 4","-","PF10154,Uncharacterized conserved protein (DUF2362)","IPR019311,Protein of unknown function DUF2362","ENOG410XS4V,-;KOG4506,Uncharacterized conserved protein","-","-"]
["KDM4C",1.398469642,0.57891068,1.267522331,3.439846651,0.003429501,0.00731006,"ENSG00000107077","K7ANB6,Lysine","-","PF13832,PHD-zinc-finger like domain;PF02375,jmjN domain;PF13831,PHD-finger;PF02373,JmjC domain, hydroxylase","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR003349,JmjN domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR034732,Extended PHD (ePHD) domain;IPR002999,Tudor domain;IPR003347,JmjC domain","COG5141,PHD zinc finger-containing protein;ENOG410IT40,-","GO:0032259,biological_process,methylation;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0008168,molecular_function,methyltransferase activity","-"]
["SLC51A",2.243152704,0.928575794,1.266544385,3.194815581,0.006318435,0.012653382,"ENSG00000163959","H2QP07,Uncharacterized protein","XP_516971.2,organic solute transporter subunit alpha","PF03619,Organic solute transporter Ostalpha","IPR005178,Organic solute transporter subunit alpha/Transmembrane protein 184","ENOG410IKZG,-;ENOG410XW07,-","GO:0032782,biological_process,bile acid secretion;GO:0032991,cellular_component,protein-containing complex;GO:0055085,biological_process,transmembrane transport;GO:0042803,molecular_function,protein homodimerization activity;GO:0071702,biological_process,organic substance transport;GO:0015721,biological_process,bile acid and bile salt transport;GO:0022857,molecular_function,transmembrane transporter activity;GO:0005886,cellular_component,plasma membrane;GO:0046982,molecular_function,protein heterodimerization activity;GO:0016020,cellular_component,membrane;GO:0015125,molecular_function,bile acid transmembrane transporter activity;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016323,cellular_component,basolateral plasma membrane;GO:0005215,molecular_function,transporter activity;GO:0016021,cellular_component,integral component of membrane","K14360,ko04976,Bile secretion"]
["CFAP97",6.414113712,2.664704171,1.265694674,5.00528197,{"v":2.45e-05,"d":"2.45E-05"},{"v":8.53E-5,"d":"8.53E-05"},"ENSG00000164323","H2PEV8,Cilia- and flagella-associated protein 97","XP_009238779.1,UPF0501 protein KIAA1430 homolog isoform X1","PF13879,KIAA1430 homologue","IPR029488,Hemingway/KIAA1430","ENOG4112B5C,-;ENOG410IFS8,-","-","-"]
["RP11-449H3.3",58.30718759,24.24570947,1.265583019,7.10404344,{"v":4.64e-08,"d":"4.64E-08"},{"v":2.94e-07,"d":"2.94E-07"},"ENSG00000275740","U3KPZ7,Uncharacterized protein","-","PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar);PF01480,PWI domain","IPR034451,Putative RNA-binding protein 27, RNA recognition motif;IPR002483,PWI domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR000571,Zinc finger, CCCH-type;IPR035979,RNA-binding domain superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0006397,biological_process,mRNA processing;GO:0046872,molecular_function,metal ion binding","-"]
["GGACT",2.731781942,1.130848818,1.265080471,2.898676593,0.014908014,0.027259932,"ENSG00000134864","H2RA08,AIG2-like domain 1","XP_003314249.1,-;XP_003314246.1,gamma-glutamylaminecyclotransferase;XP_003314248.1,-","PF06094,amma-glutamyl cyclotransferase, AIG2-like","IPR036568,Gamma-glutamyl cyclotransferase-like superfamily;IPR009288,Gamma-glutamylcyclotransferase, AIG2-like;IPR013024,Gamma-glutamyl cyclotransferase-like","ENOG4111N8W,-;KOG4450,Uncharacterized conserved protein","GO:0003839,molecular_function,gamma-glutamylcyclotransferase activity;GO:0042219,biological_process,cellular modified amino acid catabolic process","-"]
["F2RL1",3.211090538,1.329263469,1.265080471,2.898676593,0.014908014,0.027259932,"ENSG00000164251","H2QR42,F2R like trypsin receptor 1","XP_001145175.1,proteinase-activated receptor 2","PF00001,7 transmembrane receptor (rhodopsin family)","IPR017452,GPCR, rhodopsin-like, 7TM;IPR002281,Protease-activated receptor 2;IPR003912,Protease-activated receptor;IPR000276,G protein-coupled receptor, rhodopsin-like","ENOG410IGEM,-;ENOG4111CWR,-","GO:0051607,biological_process,defense response to virus;GO:0032930,biological_process,positive regulation of superoxide anion generation;GO:2000778,biological_process,positive regulation of interleukin-6 secretion;GO:0016020,cellular_component,membrane;GO:0097755,biological_process,positive regulation of blood vessel diameter;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030836,biological_process,positive regulation of actin filament depolymerization;GO:0005886,cellular_component,plasma membrane;GO:0005769,cellular_component,early endosome;GO:0031274,biological_process,positive regulation of pseudopodium assembly;GO:0035926,biological_process,chemokine (C-C motif) ligand 2 secretion;GO:0050927,biological_process,positive regulation of positive chemotaxis;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0090198,biological_process,negative regulation of chemokine secretion;GO:0097029,biological_process,mature conventional dendritic cell differentiation;GO:0050900,biological_process,leukocyte migration;GO:0046329,biological_process,negative regulation of JNK cascade;GO:0070661,biological_process,leukocyte proliferation;GO:0002286,biological_process,T cell activation involved in immune response;GO:0035025,biological_process,positive regulation of Rho protein signal transduction;GO:0034141,biological_process,positive regulation of toll-like receptor 3 signaling pathway;GO:0050921,biological_process,positive regulation of chemotaxis;GO:0031143,cellular_component,pseudopodium;GO:0030193,biological_process,regulation of blood coagulation;GO:0060100,biological_process,positive regulation of phagocytosis, engulfment;GO:0061028,biological_process,establishment of endothelial barrier;GO:0042119,biological_process,neutrophil activation;GO:0046330,biological_process,positive regulation of JNK cascade;GO:0016021,cellular_component,integral component of membrane;GO:0030335,biological_process,positive regulation of cell migration;GO:0031681,molecular_function,G-protein beta-subunit binding;GO:0002741,biological_process,positive regulation of cytokine secretion involved in immune response;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0051482,biological_process,positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0043311,biological_process,positive regulation of eosinophil degranulation;GO:0001965,molecular_function,G-protein alpha-subunit binding;GO:0072608,biological_process,interleukin-10 secretion;GO:0050702,biological_process,interleukin-1 beta secretion;GO:2000484,biological_process,positive regulation of interleukin-8 secretion;GO:0072643,biological_process,interferon-gamma secretion;GO:0045217,biological_process,cell-cell junction maintenance;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0010804,biological_process,negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0015057,molecular_function,thrombin-activated receptor activity;GO:0090195,biological_process,chemokine secretion;GO:0034137,biological_process,positive regulation of toll-like receptor 2 signaling pathway;GO:0034140,biological_process,negative regulation of toll-like receptor 3 signaling pathway;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0007596,biological_process,blood coagulation;GO:0005887,cellular_component,integral component of plasma membrane;GO:0070963,biological_process,positive regulation of neutrophil mediated killing of gram-negative bacterium;GO:1900135,biological_process,positive regulation of renin secretion into blood stream;GO:0034145,biological_process,positive regulation of toll-like receptor 4 signaling pathway;GO:0002690,biological_process,positive regulation of leukocyte chemotaxis;GO:0043122,biological_process,regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046328,biological_process,regulation of JNK cascade;GO:0007204,biological_process,positive regulation of cytosolic calcium ion concentration;GO:0070493,biological_process,thrombin-activated receptor signaling pathway","K04234,ko05143,African trypanosomiasis;K04234,ko04750,Inflammatory mediator regulation of TRP channels;K04234,ko04080,Neuroactive ligand-receptor interaction"]
["MCM9",0.760115702,0.314657598,1.265080471,2.898676593,0.014908014,0.027259932,"ENSG00000111877","K7D293,Minichromosome maintenance complex component 9","-","PF00493,MCM2/3/5 family;PF17207,MCM OB domain","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001208,MCM domain;IPR033762,MCM OB domain;IPR031327,Mini-chromosome maintenance protein;IPR003593,AAA+ ATPase domain;IPR012340,Nucleic acid-binding, OB-fold","KOG0477,DNA replication licensing factor, MCM2 component;COG1241,Predicted ATPase involved in replication control, Cdc46/Mcm family","GO:0006270,biological_process,DNA replication initiation;GO:0003677,molecular_function,DNA binding;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["CDCA2",12.69937829,5.282189621,1.264146523,5.169946702,{"v":1.23e-05,"d":"1.23E-05"},{"v":4.59e-05,"d":"4.59E-05"},"ENSG00000184661","K7DDS0,Cell division cycle associated 2","-","PF15276,Protein phosphatase 1 binding","IPR033064,Cell division cycle-associated protein 2;IPR029334,Protein phosphatase 1 binding domain","ENOG410IU6S,-;ENOG410YZZ3,-","GO:0035307,biological_process,positive regulation of protein dephosphorylation;GO:0051301,biological_process,cell division","-"]
["TP53",7.05738194,2.935795727,1.263226677,4.567110595,1.17675E-4,3.50193E-4,"ENSG00000141510","A0A0U1RQC9,Cellular tumor antigen p53","-","PF00870,P53 DNA-binding domain;PF07710,P53 tetramerisation motif","IPR002117,p53 tumour suppressor family;IPR011615,p53, DNA-binding domain;IPR008967,p53-like transcription factor, DNA-binding;IPR012346,p53/RUNT-type transcription factor, DNA-binding domain superfamily;IPR010991,p53, tetramerisation domain;IPR036674,p53-like tetramerisation domain superfamily","-","GO:0051262,biological_process,protein tetramerization;GO:0006915,biological_process,apoptotic process;GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0007049,biological_process,cell cycle;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0016020,cellular_component,membrane;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","-"]
["PERP",21.64263795,9.0126542,1.263103383,6.05840899,{"v":7.01e-07,"d":"7.01E-07"},{"v":3.42e-06,"d":"3.42E-06"},"ENSG00000112378","I7G804,Macaca fascicularis brain cDNA clone: QmoA-11464, similar to human PERP, TP53 apoptosis effector","NP_001271930.1,p53 apoptosis effector related to PMP-22","PF00822,PMP-22/EMP/MP20/Claudin family","IPR004031,PMP-22/EMP/MP20/Claudin superfamily;IPR015664,P53-induced protein","-","GO:0045862,biological_process,positive regulation of proteolysis;GO:0097202,biological_process,activation of cysteine-type endopeptidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K10136,ko04115,p53 signaling pathway"]
["TCTN3",2.210302314,0.914977042,1.262648593,2.524120121,0.03246835,0.054051221,"ENSG00000119977","A0A0C4DFN5,Chromosome 10 open reading frame 61","-","PF07773,Protein of unknown function (DUF1619)","IPR011677,Domain of unknown function DUF1619","ENOG410IFR0,-;ENOG4111GX2,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["WDR7",0.453918973,0.187904359,1.262648593,2.524120121,0.03246835,0.054051221,"ENSG00000091157","H2QEK6,Uncharacterized protein","XP_523934.2,WD repeat-containing protein 7 isoform X2","PF00400,WD domain, G-beta repeat","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily;IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat","ENOG410ISJ1,-;ENOG410Y2AE,-","GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0005737,cellular_component,cytoplasm","-"]
["COPS7A",12.89134743,5.368080854,1.262193082,4.871544701,{"v":4.36e-05,"d":"4.36E-05"},1.437E-4,"ENSG00000111652","A0A250YE84,COP9 signalosome complex subunit 7a","XP_020013895.1,-;XP_020013894.1,-;XP_020013893.1,-;XP_020013892.1,-;XP_020013891.1,-","-","IPR000717,Proteasome component (PCI) domain;IPR037757,COP9 Signalosome complex subunit 7A","-","GO:0008180,cellular_component,COP9 signalosome","-"]
["PELO",3.985879652,1.657529499,1.261853109,3.707778713,1.837869E-3,0.004191132,"ENSG00000152684","A0A024QZR3,Protein pelota homolog","-","PF03465,eRF1 domain 3;PF03463,eRF1 domain 1;PF03464,eRF1 domain 2","IPR005142,eRF1 domain 3;IPR004405,Translation release factor  pelota;IPR038069,Pelota/DOM34, N-terminal domain;IPR029064,50S ribosomal protein L30e-like;IPR005140,eRF1 domain 1/Pelota-like;IPR005141,eRF1 domain 2","KOG2869,Meiotic cell division protein Pelota/DOM34;COG1537,Predicted RNA-binding proteins","GO:0016787,molecular_function,hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0046872,molecular_function,metal ion binding;GO:0004518,molecular_function,nuclease activity;GO:0070481,biological_process,nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0071025,biological_process,RNA surveillance;GO:0070966,biological_process,nuclear-transcribed mRNA catabolic process, no-go decay;GO:0005634,cellular_component,nucleus;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0004519,molecular_function,endonuclease activity","-"]
["CCDC125",2.185399723,0.908799268,1.261853109,3.707778713,1.837869E-3,0.004191132,"ENSG00000183323","K7BTT6,Coiled-coil domain containing 125","-","-","-","-","-","-"]
["PIEZO1",6.048000036,2.521642637,1.26104329,5.574259503,{"v":3.35e-06,"d":"3.35E-06"},{"v":1.41e-05,"d":"1.41E-05"},"ENSG00000103335","M4QHP2,Piezo-type mechanosensitive ion channel component","-","PF12166,Piezo non-specific cation channel, R-Ras-binding domain;PF15917,Piezo","IPR031805,Piezo domain;IPR027272,Piezo family;IPR031334,Piezo non-specific cation channel, R-Ras-binding domain","KOG1893,Uncharacterized conserved protein;ENOG410YVF6,-","GO:0055085,biological_process,transmembrane transport;GO:0008381,molecular_function,mechanosensitive ion channel activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SMAD4",1.91806564,0.798996437,1.260634372,4.221200313,3.85752E-4,1.025593E-3,"ENSG00000141646","G7PWS9,Mothers against decapentaplegic homolog","XP_005586732.1,-","PF03165,MH1 domain;PF03166,MH2 domain","IPR003619,MAD homology 1, Dwarfin-type;IPR001132,SMAD domain, Dwarfin-type;IPR013790,Dwarfin;IPR017855,SMAD-like domain superfamily;IPR008984,SMAD/FHA domain superfamily;IPR036578,SMAD MH1 domain superfamily;IPR013019,MAD homology, MH1","-","GO:0007283,biological_process,spermatogenesis;GO:2000617,biological_process,positive regulation of histone H3-K9 acetylation;GO:0071141,cellular_component,SMAD protein complex;GO:0005518,molecular_function,collagen binding;GO:0060391,biological_process,positive regulation of SMAD protein signal transduction;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001666,biological_process,response to hypoxia;GO:0046982,molecular_function,protein heterodimerization activity;GO:0017015,biological_process,regulation of transforming growth factor beta receptor signaling pathway;GO:0005634,cellular_component,nucleus;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0033686,biological_process,positive regulation of luteinizing hormone secretion;GO:0032525,biological_process,somite rostral/caudal axis specification;GO:0003279,biological_process,cardiac septum development;GO:0001822,biological_process,kidney development;GO:0008585,biological_process,female gonad development;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0032909,biological_process,regulation of transforming growth factor beta2 production;GO:0007338,biological_process,single fertilization;GO:0030308,biological_process,negative regulation of cell growth;GO:0005829,cellular_component,cytosol;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005667,cellular_component,transcription factor complex;GO:0061614,biological_process,pri-miRNA transcription by RNA polymerase II;GO:0042802,molecular_function,identical protein binding;GO:0008584,biological_process,male gonad development;GO:0007183,biological_process,SMAD protein complex assembly;GO:0001541,biological_process,ovarian follicle development;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0070102,biological_process,interleukin-6-mediated signaling pathway;GO:1905305,biological_process,negative regulation of cardiac myofibril assembly;GO:0048859,biological_process,formation of anatomical boundary;GO:0060395,biological_process,SMAD protein signal transduction;GO:0035556,biological_process,intracellular signal transduction;GO:0060956,biological_process,endocardial cell differentiation;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0003148,biological_process,outflow tract septum morphogenesis;GO:0003682,molecular_function,chromatin binding;GO:0048663,biological_process,neuron fate commitment;GO:0010614,biological_process,negative regulation of cardiac muscle hypertrophy;GO:0007411,biological_process,axon guidance;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0032444,cellular_component,activin responsive factor complex;GO:0042733,biological_process,embryonic digit morphogenesis;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0048733,biological_process,sebaceous gland development;GO:0001701,biological_process,in utero embryonic development;GO:0014033,biological_process,neural crest cell differentiation;GO:0005622,cellular_component,intracellular;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0003190,biological_process,atrioventricular valve formation;GO:0030511,biological_process,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0072520,biological_process,seminiferous tubule development;GO:0003198,biological_process,epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0070411,molecular_function,I-SMAD binding;GO:0060021,biological_process,roof of mouth development;GO:0042803,molecular_function,protein homodimerization activity;GO:0060548,biological_process,negative regulation of cell death;GO:0000989,molecular_function,transcription factor activity, transcription factor binding;GO:0048729,biological_process,tissue morphogenesis;GO:0030509,biological_process,BMP signaling pathway;GO:0005813,cellular_component,centrosome;GO:0000790,cellular_component,nuclear chromatin;GO:0010862,biological_process,positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042127,biological_process,regulation of cell proliferation;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0007369,biological_process,gastrulation;GO:0001085,molecular_function,RNA polymerase II transcription factor binding;GO:0090575,cellular_component,RNA polymerase II transcription factor complex;GO:0003220,biological_process,left ventricular cardiac muscle tissue morphogenesis;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0060412,biological_process,ventricular septum morphogenesis;GO:0001702,biological_process,gastrulation with mouth forming second;GO:0070207,biological_process,protein homotrimerization;GO:0051571,biological_process,positive regulation of histone H3-K4 methylation;GO:0046881,biological_process,positive regulation of follicle-stimulating hormone secretion;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0070412,molecular_function,R-SMAD binding;GO:0007498,biological_process,mesoderm development;GO:0051797,biological_process,regulation of hair follicle development;GO:0005737,cellular_component,cytoplasm;GO:0042118,biological_process,endothelial cell activation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0030616,molecular_function,transforming growth factor beta receptor, common-partner cytoplasmic mediator activity;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0072134,biological_process,nephrogenic mesenchyme morphogenesis;GO:0072133,biological_process,metanephric mesenchyme morphogenesis;GO:0001658,biological_process,branching involved in ureteric bud morphogenesis;GO:0060065,biological_process,uterus development;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0003677,molecular_function,DNA binding;GO:0001076,molecular_function,transcription factor activity, RNA polymerase II transcription factor binding;GO:0043199,molecular_function,sulfate binding;GO:0003360,biological_process,brainstem development;GO:0003251,biological_process,positive regulation of cell proliferation involved in heart valve morphogenesis;GO:0051098,biological_process,regulation of binding;GO:0071559,biological_process,response to transforming growth factor beta;GO:0007492,biological_process,endoderm development;GO:0005654,cellular_component,nucleoplasm;GO:0036302,biological_process,atrioventricular canal development;GO:0008283,biological_process,cell proliferation;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0000987,molecular_function,proximal promoter sequence-specific DNA binding;GO:0061040,biological_process,female gonad morphogenesis;GO:0048589,biological_process,developmental growth;GO:0030513,biological_process,positive regulation of BMP signaling pathway","K04501,ko05220,Chronic myeloid leukemia;K04501,ko05166,HTLV-I infection;K04501,ko05210,Colorectal cancer;K04501,ko04550,Signaling pathways regulating pluripotency of stem cells;K04501,ko04390,Hippo signaling pathway;K04501,ko05212,Pancreatic cancer;K04501,ko04350,TGF-beta signaling pathway;K04501,ko05200,Pathways in cancer;K04501,ko04110,Cell cycle;K04501,ko05161,Hepatitis B;K04501,ko04310,Wnt signaling pathway;K04501,ko04068,FoxO signaling pathway;K04501,ko04933,AGE-RAGE signaling pathway in diabetic complications;K04501,ko04520,Adherens junction"]
["GGA1",1.596754099,0.664489856,1.260184199,3.507779586,0.003161754,0.006791525,"ENSG00000100083","G3RF82,Golgi associated, gamma adaptin ear containing, ARF binding protein 1","XP_018873776.1,ADP-ribosylation factor-binding protein GGA1 isoform X1","PF00790,VHS domain;PF03127,AT domain;PF02883,Adaptin C-terminal domain","IPR013041,Clathrin adaptor, appendage, Ig-like subdomain superfamily;IPR008152,Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain;IPR008942,ENTH/VHS;IPR038425,GAT domain superfamily;IPR002014,VHS domain;IPR008153,Gamma-adaptin ear (GAE) domain;IPR004152,GAT domain","-","GO:0016192,biological_process,vesicle-mediated transport;GO:0030131,cellular_component,clathrin adaptor complex;GO:0005622,cellular_component,intracellular;GO:0006886,biological_process,intracellular protein transport","-"]
["SHCBP1",5.112396041,2.131024873,1.259412387,4.084491487,4.68899E-4,0.001219455,"ENSG00000171241","A0A024R6R1,SHC SH2-domain binding protein 1, isoform CRA_a","NP_079021.3,SHC SH2 domain-binding protein 1 isoform 1","PF13229,Right handed beta helix region","IPR011050,Pectin lyase fold/virulence factor;IPR006626,Parallel beta-helix repeat;IPR012334,Pectin lyase fold","ENOG410IIV2,-;ENOG410XXTE,-","-","-"]
["CCNA2",34.20172929,14.28696937,1.258646479,6.102747077,{"v":7.2e-07,"d":"7.20E-07"},{"v":3.5e-06,"d":"3.50E-06"},"ENSG00000145386","G3QIC8,Cyclin A2","XP_004040395.1,cyclin-A2","PF02984,Cyclin, C-terminal domain;PF16500,N-terminal region of cyclin_N;PF00134,Cyclin, N-terminal domain","IPR032447,Cyclin-A, N-terminal;IPR004367,Cyclin, C-terminal domain;IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","-","GO:0019904,molecular_function,protein domain specific binding;GO:0019901,molecular_function,protein kinase binding;GO:0097124,cellular_component,cyclin A2-CDK2 complex;GO:0007265,biological_process,Ras protein signal transduction;GO:0097472,molecular_function,cyclin-dependent protein kinase activity;GO:0001940,cellular_component,male pronucleus;GO:0016572,biological_process,histone phosphorylation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0001939,cellular_component,female pronucleus;GO:0005737,cellular_component,cytoplasm;GO:0044843,biological_process,cell cycle G1/S phase transition;GO:0000086,biological_process,G2/M transition of mitotic cell cycle;GO:0005829,cellular_component,cytosol;GO:0051726,biological_process,regulation of cell cycle;GO:0000307,cellular_component,cyclin-dependent protein kinase holoenzyme complex;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","K06627,ko05169,Epstein-Barr virus infection;K06627,ko04110,Cell cycle;K06627,ko04914,Progesterone-mediated oocyte maturation;K06627,ko05203,Viral carcinogenesis;K06627,ko05161,Hepatitis B;K06627,ko04152,AMPK signaling pathway"]
["RAB4B-EGLN2",19.99471289,8.352949933,1.257925407,5.231175669,{"v":1.04E-5,"d":"1.04E-05"},{"v":3.94e-05,"d":"3.94E-05"},"ENSG00000171570","A0A0P6K3Y0,Ras-related protein Rab-4B","XP_004874290.1,-;XP_004874291.1,-;XP_004874292.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0003924,molecular_function,GTPase activity;GO:0005525,molecular_function,GTP binding;GO:0005739,cellular_component,mitochondrion","-"]
["RBPJ",3.900782674,1.628933154,1.257920513,4.724075193,{"v":6.98e-05,"d":"6.98E-05"},0.000219016,"ENSG00000168214","H2R2Q6,Uncharacterized protein","-","PF09271,LAG1, DNA binding;PF09270,Beta-trefoil DNA-binding domain","IPR015350,Beta-trefoil DNA-binding domain;IPR015351,RBP-J/Cbf11/Cbf12, DNA binding;IPR037095,RBP-J/Cbf11/Cbf12, DNA binding domain superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR036358,Beta-trefoil domain superfamily;IPR038007,RBP-Jkappa, IPT domain;IPR013783,Immunoglobulin-like fold;IPR014756,Immunoglobulin E-set","ENOG410XV7K,-;KOG3743,Recombination signal binding protein-J kappa(CBF1, Su(H), HS2NF5)","GO:0000982,molecular_function,transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","K06053,ko05169,Epstein-Barr virus infection;K06053,ko04330,Notch signaling pathway;K06053,ko05203,Viral carcinogenesis"]
["AC004754.3",12.60381681,5.261322044,1.257916032,4.382501419,0.000210555,0.000594988,"ENSG00000269881","B4DGG1,cDNA FLJ60496","-","-","IPR011047,Quinoprotein alcohol dehydrogenase-like superfamily","ENOG4111VVF,-;ENOG410IF25,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TMUB2",3.584559299,1.493197129,1.25789038,3.275113882,0.006804463,0.013499042,"ENSG00000168591","H2QD66,Transmembrane and ubiquitin-like domain containing 2","XP_003953053.1,-;XP_009430310.2,-;XP_016787182.1,-;XP_016787183.1,-;XP_003953054.1,-;XP_003953051.1,-;XP_016787181.1,-;XP_016787180.1,-","PF00240,Ubiquitin family","IPR000626,Ubiquitin domain;IPR029071,Ubiquitin-like domain superfamily","ENOG410IG1T,-;ENOG4111WH7,-","-","-"]
["AC084219.4",3.608196015,1.503043326,1.25789038,3.275113882,0.006804463,0.013499042,"ENSG00000186019","A0A024R0Q3,Zinc finger protein 224, isoform CRA_a","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["MDM4",3.775029563,1.577594712,1.257099165,4.921953806,{"v":3.06e-05,"d":"3.06E-05"},1.03905E-4,"ENSG00000198625","A0A024R990,Mdm4, transformed 3T3 cell double minute 4, p53 binding protein","NP_002384.2,protein Mdm4 isoform 1","PF13920,Zinc finger, C3HC4 type (RING finger);PF00641,Zn-finger in Ran binding protein and others;PF02201,SWIB/MDM2 domain","IPR003121,SWIB/MDM2 domain;IPR036885,SWIB/MDM2 domain superfamily;IPR036443,Zinc finger, RanBP2-type superfamily;IPR015458,MDM4;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR016495,p53 negative regulator Mdm2/Mdm4;IPR001876,Zinc finger, RanBP2-type","ENOG410XSWN,-;ENOG410IE9V,-","GO:0071157,biological_process,negative regulation of cell cycle arrest;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0043066,biological_process,negative regulation of apoptotic process","K10127,ko04115,p53 signaling pathway;K10127,ko05206,MicroRNAs in cancer"]
["PBRM1",3.492784403,1.459449776,1.256904797,4.629145857,{"v":9.27e-05,"d":"9.27E-05"},0.000281775,"ENSG00000163939","G1R6B7,Polybromo 1","-","PF00505,HMG (high mobility group) box;PF00439,Bromodomain;PF01426,BAH domain","IPR009071,High mobility group box domain;IPR001025,Bromo adjacent homology (BAH) domain;IPR037382,Remodelling complex subunit Rsc/polybromo;IPR036427,Bromodomain-like superfamily;IPR001487,Bromodomain;IPR037968,Protein polybromo-1, Bromodomain 5;IPR018359,Bromodomain, conserved site;IPR036910,High mobility group box domain superfamily","KOG1827,Chromatin remodeling complex RSC, subunit RSC1/Polybromo and related proteins;COG5076,Transcription factor involved in chromatin remodeling, contains bromodomain","GO:0003677,molecular_function,DNA binding;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0006338,biological_process,chromatin remodeling;GO:0016586,cellular_component,RSC-type complex;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","-"]
["RAB25",32.28563482,13.49996537,1.256678287,5.313337428,{"v":8.68e-06,"d":"8.68E-06"},{"v":3.34e-05,"d":"3.34E-05"},"ENSG00000132698","A0A0D9S4Z9,RAB25, member RAS oncogene family","XP_007974985.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0031410,cellular_component,cytoplasmic vesicle;GO:0060627,biological_process,regulation of vesicle-mediated transport;GO:0005525,molecular_function,GTP binding;GO:0031143,cellular_component,pseudopodium;GO:0031268,biological_process,pseudopodium organization;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0003382,biological_process,epithelial cell morphogenesis;GO:0010634,biological_process,positive regulation of epithelial cell migration;GO:0003924,molecular_function,GTPase activity;GO:0031489,molecular_function,myosin V binding","-"]
["DNAAF2",8.735455901,3.649306003,1.25659295,4.260969318,0.000302024,0.000821302,"ENSG00000165506","H2Q890,Protein kintoun","XP_509930.3,protein kintoun isoform X1","PF08190,pre-RNA processing PIH1/Nop17","IPR012981,PIH1 domain;IPR034727,Kintoun","KOG4356,Uncharacterized conserved protein;ENOG410XQ8C,-","GO:0005737,cellular_component,cytoplasm;GO:0005829,cellular_component,cytosol;GO:0060285,biological_process,cilium-dependent cell motility;GO:0070286,biological_process,axonemal dynein complex assembly","-"]
["SLC7A6OS",7.493005158,3.133136786,1.256175675,4.83958951,{"v":3.88e-05,"d":"3.88E-05"},0.000129089,"ENSG00000103061","G3QGT0,Solute carrier family 7 member 6 opposite strand","-","PF08574,Transcription factor Iwr1","-","-","GO:0002244,biological_process,hematopoietic progenitor cell differentiation","-"]
["TUBE1",5.618947938,2.349515596,1.256175675,4.83958951,{"v":3.88e-05,"d":"3.88E-05"},0.000129089,"ENSG00000074935","G2HJS7,Tubulin epsilon chain","NP_001233321.1,tubulin epsilon chain","PF03953,Tubulin C-terminal domain;PF00091,Tubulin/FtsZ family, GTPase domain","IPR017975,Tubulin, conserved site;IPR004057,Epsilon tubulin;IPR003008,Tubulin/FtsZ, GTPase domain;IPR008280,Tubulin/FtsZ, C-terminal;IPR036525,Tubulin/FtsZ, GTPase domain superfamily;IPR018316,Tubulin/FtsZ, 2-layer sandwich domain;IPR000217,Tubulin;IPR023123,Tubulin, C-terminal","KOG1375,Beta tubulin;COG5023,Tubulin;ENOG4110BH0,-;ENOG410IJZE,-","GO:0005525,molecular_function,GTP binding;GO:0007017,biological_process,microtubule-based process;GO:0003924,molecular_function,GTPase activity;GO:0005874,cellular_component,microtubule;GO:0000166,molecular_function,nucleotide binding","-"]
["MCM7",32.64670944,13.67132021,1.255303862,6.679102978,{"v":1.56e-07,"d":"1.56E-07"},{"v":8.75e-07,"d":"8.75E-07"},"ENSG00000166508","A0A0S2Z4A5,DNA helicase","NP_005907.3,DNA replication licensing factor MCM7 isoform 1","PF00493,MCM2/3/5 family;PF17207,MCM OB domain;PF14551,MCM N-terminal domain","IPR008050,DNA replication licensing factor Mcm7;IPR018525,Mini-chromosome maintenance, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001208,MCM domain;IPR033762,MCM OB domain;IPR031327,Mini-chromosome maintenance protein;IPR003593,AAA+ ATPase domain;IPR027925,MCM N-terminal domain;IPR012340,Nucleic acid-binding, OB-fold","-","GO:0003697,molecular_function,single-stranded DNA binding;GO:0016787,molecular_function,hydrolase activity;GO:0003677,molecular_function,DNA binding;GO:0006270,biological_process,DNA replication initiation;GO:0008283,biological_process,cell proliferation;GO:0006260,biological_process,DNA replication;GO:0006268,biological_process,DNA unwinding involved in DNA replication;GO:0071310,biological_process,cellular response to organic substance;GO:0071466,biological_process,cellular response to xenobiotic stimulus;GO:0005524,molecular_function,ATP binding;GO:0042555,cellular_component,MCM complex;GO:0004386,molecular_function,helicase activity;GO:0071364,biological_process,cellular response to epidermal growth factor stimulus;GO:0005829,cellular_component,cytosol;GO:0003678,molecular_function,DNA helicase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0042493,biological_process,response to drug;GO:0005654,cellular_component,nucleoplasm","K02210,ko04110,Cell cycle;K02210,ko04113,Meiosis - yeast;K02210,ko03030,DNA replication;K02210,ko04111,Cell cycle - yeast"]
["KIF1C",31.6336767,13.25165681,1.255034763,7.595935018,{"v":2.19e-08,"d":"2.19E-08"},{"v":1.49E-7,"d":"1.49E-07"},"ENSG00000129250","K7BP32,Kinesin family member 1C","XP_016786804.1,-;XP_016786803.1,kinesin-like protein KIF1C","PF16183,Kinesin-associated;PF00225,Kinesin motor domain;PF00498,HA domain","IPR019821,Kinesin motor domain, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR032405,Kinesin-associated;IPR000253,Forkhead-associated (FHA) domain;IPR008984,SMAD/FHA domain superfamily;IPR001752,Kinesin motor domain;IPR036961,Kinesin motor domain superfamily;IPR027640,Kinesin-like protein","COG5059,Kinesin-like protein;KOG0245,Kinesin-like protein","GO:0005794,cellular_component,Golgi apparatus;GO:0003777,molecular_function,microtubule motor activity;GO:0003774,molecular_function,motor activity;GO:0006890,biological_process,retrograde vesicle-mediated transport, Golgi to ER;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["SLC5A10",1.582822236,0.660304571,1.254539816,2.996892687,0.013344203,0.024714957,"ENSG00000154025","G3RAD5,Solute carrier family 5 member 10","XP_004042189.1,sodium/glucose cotransporter 5 isoform X1","PF00474,Sodium:solute symporter family","IPR038377,Sodium/glucose symporter superfamily;IPR001734,Sodium/solute symporter;IPR018212,Sodium/solute symporter, conserved site","-","GO:0055085,biological_process,transmembrane transport;GO:0022857,molecular_function,transmembrane transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CLDN4",18.13019825,7.595771058,1.254319051,5.939362046,{"v":1.07e-06,"d":"1.07E-06"},{"v":5.03e-06,"d":"5.03E-06"},"ENSG00000189143","H2PLX4,Claudin","XP_002817903.1,-;XP_002817902.1,-","PF00822,PMP-22/EMP/MP20/Claudin family","IPR017974,Claudin, conserved site;IPR006187,Claudin;IPR003550,Claudin-4;IPR004031,PMP-22/EMP/MP20/Claudin superfamily","ENOG410YA61,-;ENOG410IIJR,-","GO:0030054,cellular_component,cell junction;GO:1902476,biological_process,chloride transmembrane transport;GO:0005923,cellular_component,bicellular tight junction;GO:0070293,biological_process,renal absorption;GO:0016020,cellular_component,membrane;GO:0005254,molecular_function,chloride channel activity;GO:0005886,cellular_component,plasma membrane;GO:0005198,molecular_function,structural molecule activity;GO:0016327,cellular_component,apicolateral plasma membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0061436,biological_process,establishment of skin barrier","K06087,ko04514,Cell adhesion molecules (CAMs);K06087,ko04670,Leukocyte transendothelial migration;K06087,ko04530,Tight junction;K06087,ko05160,Hepatitis C"]
["TFB1M",5.728205259,2.395200622,1.253543953,3.572634382,0.00228741,0.005116231,"ENSG00000029639","G3R924,rRNA adenine N","XP_004044918.1,-","PF00398,Ribosomal RNA adenine dimethylase","IPR020596,Ribosomal RNA adenine methylase transferase, conserved site;IPR023165,rRNA adenine dimethylase-like;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR001737,Ribosomal RNA adenine methyltransferase KsgA/Erm;IPR020598,Ribosomal RNA adenine methylase transferase, N-terminal;IPR011530,Ribosomal RNA adenine dimethylase","-","GO:0008649,molecular_function,rRNA methyltransferase activity;GO:0042645,cellular_component,mitochondrial nucleoid;GO:0031167,biological_process,rRNA methylation;GO:0016740,molecular_function,transferase activity;GO:0003723,molecular_function,RNA binding;GO:0008168,molecular_function,methyltransferase activity;GO:0000179,molecular_function,rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0032259,biological_process,methylation;GO:0000154,biological_process,rRNA modification;GO:0006364,biological_process,rRNA processing;GO:0005739,cellular_component,mitochondrion","-"]
["SPAG1",10.05271436,4.21327872,1.253217023,5.206358236,{"v":1.2E-5,"d":"1.20E-05"},{"v":4.49E-5,"d":"4.49E-05"},"ENSG00000104450","A0A024R9D8,Sperm associated antigen 1, isoform CRA_b","-","PF13877,Potential Monad-binding region of RPAP3;PF00515,Tetratricopeptide repeat;PF13181,Tetratricopeptide repeat","IPR001440,Tetratricopeptide repeat 1;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR025986,RNA-polymerase II-associated protein 3-like, C-terminal domain","KOG1124,FOG: TPR repeat;COG0457,FOG: TPR repeat","-","-"]
["ICA1",4.320988127,1.808814765,1.253062215,3.981805595,0.000799628,0.001972473,"ENSG00000003147","G7P1A4,Uncharacterized protein","-","PF06456,Arfaptin-like domain;PF04629,Islet cell autoantigen ICA69, C-terminal domain","IPR010504,Arfaptin homology (AH) domain;IPR027267,AH/BAR domain superfamily;IPR024114,Islet cell autoantigen 1/Ica1-like;IPR006723,Islet cell autoantigen Ica1, C-terminal;IPR030796,Islet cell autoantigen 1","-","GO:0019904,molecular_function,protein domain specific binding;GO:0030667,cellular_component,secretory granule membrane;GO:0000139,cellular_component,Golgi membrane;GO:0050796,biological_process,regulation of insulin secretion","-"]
["ETF1",75.19657285,31.548556,1.252894396,7.945308429,{"v":1.41e-08,"d":"1.41E-08"},{"v":1e-07,"d":"1.00E-07"},"ENSG00000120705","A0A250YI86,Eukaryotic peptide chain release factor subunit 1","-","-","IPR005142,eRF1 domain 3;IPR024049,Peptide Chain Release Factor eRF1/aRF1, N-terminal;IPR029064,50S ribosomal protein L30e-like;IPR005140,eRF1 domain 1/Pelota-like;IPR005141,eRF1 domain 2;IPR004403,Peptide chain release factor eRF1/aRF1","-","GO:0005737,cellular_component,cytoplasm;GO:0006415,biological_process,translational termination;GO:0003747,molecular_function,translation release factor activity","-"]
["KPNA3",19.37258673,8.129334467,1.252015586,5.963608434,{"v":1.19E-6,"d":"1.19E-06"},{"v":5.55e-06,"d":"5.55E-06"},"ENSG00000102753","H2Q7K7,Importin subunit alpha","XP_016780781.1,-","PF01749,Importin beta binding domain;PF16186,Atypical Arm repeat;PF00514,Armadillo/beta-catenin-like repeat","IPR002652,Importin-alpha, importin-beta-binding domain;IPR024931,Importin subunit alpha;IPR036975,Importin-alpha, importin-beta-binding domain superfamily;IPR032413,Atypical Arm repeat;IPR000225,Armadillo;IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical","COG5064,Karyopherin (importin) alpha;KOG0166,Karyopherin (importin) alpha","GO:0005643,cellular_component,nuclear pore;GO:0061608,molecular_function,nuclear import signal receptor activity;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0006606,biological_process,protein import into nucleus;GO:0008139,molecular_function,nuclear localization sequence binding;GO:0008022,molecular_function,protein C-terminus binding;GO:0006607,biological_process,NLS-bearing protein import into nucleus;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0008565,molecular_function,protein transporter activity;GO:0005654,cellular_component,nucleoplasm","-"]
["PPIF",9.057941219,3.798641286,1.250867941,4.170569751,0.00049519,1.281822E-3,"ENSG00000108179","A0A024QZS4,Peptidyl-prolyl cis-trans isomerase","NP_005720.1,peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor","PF00160,Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD","IPR024936,Cyclophilin-type peptidyl-prolyl cis-trans isomerase;IPR029000,Cyclophilin-like domain superfamily;IPR020892,Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site;IPR002130,Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain","COG0652,Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family;KOG0865,Cyclophilin type peptidyl-prolyl cis-trans isomerase","GO:0071243,biological_process,cellular response to arsenic-containing substance;GO:0006457,biological_process,protein folding;GO:2000276,biological_process,negative regulation of oxidative phosphorylation uncoupler activity;GO:0003755,molecular_function,peptidyl-prolyl cis-trans isomerase activity;GO:0090200,biological_process,positive regulation of release of cytochrome c from mitochondria;GO:0000413,biological_process,protein peptidyl-prolyl isomerization;GO:0032780,biological_process,negative regulation of ATPase activity;GO:0042277,molecular_function,peptide binding;GO:0070266,biological_process,necroptotic process;GO:0008637,biological_process,apoptotic mitochondrial changes;GO:1902445,biological_process,regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;GO:0005759,cellular_component,mitochondrial matrix;GO:0005739,cellular_component,mitochondrion;GO:0046902,biological_process,regulation of mitochondrial membrane permeability;GO:0070301,biological_process,cellular response to hydrogen peroxide;GO:0042981,biological_process,regulation of apoptotic process;GO:0006979,biological_process,response to oxidative stress;GO:0010849,biological_process,regulation of proton-transporting ATPase activity, rotational mechanism;GO:0002931,biological_process,response to ischemia;GO:0071277,biological_process,cellular response to calcium ion;GO:0090324,biological_process,negative regulation of oxidative phosphorylation;GO:0016018,molecular_function,cyclosporin A binding;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0016853,molecular_function,isomerase activity;GO:0010939,biological_process,regulation of necrotic cell death","K09565,ko04020,Calcium signaling pathway;K09565,ko05016,Huntington's disease;K09565,ko04022,cGMP-PKG signaling pathway;K09565,ko05145,Toxoplasmosis;K09565,ko05012,Parkinson's disease"]
["MAD2L2",5.643607544,2.365801048,1.250632706,3.818748724,0.001274729,0.003000032,"ENSG00000116670","G3R1V9,Mitotic arrest deficient 2 like 2","XP_018866713.1,-;XP_018866705.1,-;XP_004024700.1,-;XP_004024699.1,-","PF02301,HORMA domain","IPR003511,HORMA domain;IPR036570,HORMA domain superfamily","-","-","-"]
["SNAP47",8.300278635,3.485781331,1.25042323,5.308967706,{"v":8.68e-06,"d":"8.68E-06"},{"v":3.34e-05,"d":"3.34E-05"},"ENSG00000143740","H2Q192,Synaptosome associated protein 47","XP_003308840.2,synaptosomal-associated protein 47 isoform X1","-","IPR000727,Target SNARE coiled-coil homology domain;IPR011993,PH-like domain superfamily","ENOG410Y3Y0,-;KOG3065,SNAP-25 (synaptosome-associated protein) component of SNARE complex","GO:0031201,cellular_component,SNARE complex;GO:0005484,molecular_function,SNAP receptor activity;GO:0060291,biological_process,long-term synaptic potentiation;GO:0030425,cellular_component,dendrite;GO:0043025,cellular_component,neuronal cell body;GO:0031083,cellular_component,BLOC-1 complex;GO:0031629,biological_process,synaptic vesicle fusion to presynaptic active zone membrane;GO:0019905,molecular_function,syntaxin binding;GO:0016082,biological_process,synaptic vesicle priming;GO:0005886,cellular_component,plasma membrane;GO:0030672,cellular_component,synaptic vesicle membrane;GO:0016020,cellular_component,membrane;GO:0098967,biological_process,exocytic insertion of neurotransmitter receptor to postsynaptic membrane","-"]
["RIC8A",10.72744411,4.509354816,1.249359372,5.695046193,{"v":2.64e-06,"d":"2.64E-06"},{"v":1.14e-05,"d":"1.14E-05"},"ENSG00000177963","H2Q2U3,Resistance to inhibitors of cholinesterase 8 homolog A","XP_001143336.1,synembryn-A isoform X2","PF10165,uanine nucleotide exchange factor synembryn","IPR011989,Armadillo-like helical;IPR008376,Synembryn;IPR019318,Guanine nucleotide exchange factor, Ric8;IPR016024,Armadillo-type fold","ENOG410XSCJ,-;KOG4464,Signaling protein RIC-8/synembryn (regulates neurotransmitter secretion)","GO:0070586,biological_process,cell-cell adhesion involved in gastrulation;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0005096,molecular_function,GTPase activator activity;GO:0009416,biological_process,response to light stimulus;GO:0001944,biological_process,vasculature development;GO:0005737,cellular_component,cytoplasm;GO:0001965,molecular_function,G-protein alpha-subunit binding;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0007193,biological_process,adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007369,biological_process,gastrulation;GO:0065009,biological_process,regulation of molecular function;GO:0042074,biological_process,cell migration involved in gastrulation;GO:0008542,biological_process,visual learning;GO:0001701,biological_process,in utero embryonic development;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0071711,biological_process,basement membrane organization;GO:0043547,biological_process,positive regulation of GTPase activity","-"]
["CTD-2619J13.14",2.293293765,0.958921408,1.249183675,2.650647987,0.021118495,0.036905358,"ENSG00000232098","Q9BZ57,FKSG67","-","-","-","-","-","-"]
["CARHSP1",7.408654344,3.113889652,1.248838411,4.91619836,{"v":3.57E-5,"d":"3.57E-05"},1.20096E-4,"ENSG00000153048","H2QAJ7,Calcium regulated heat stable protein 1","XP_009428547.1,-;XP_016784879.1,-;XP_009428548.1,-;XP_001138086.1,-;XP_016784878.1,-;XP_001138007.1,-","PF00313,'Cold-shock' DNA-binding domain","IPR019844,Cold-shock conserved site;IPR002059,Cold-shock protein, DNA-binding;IPR011129,Cold shock domain;IPR012340,Nucleic acid-binding, OB-fold","KOG3070,Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing;COG1278,Cold shock proteins","GO:0003677,molecular_function,DNA binding;GO:0000177,cellular_component,cytoplasmic exosome (RNase complex);GO:0003730,molecular_function,mRNA 3'-UTR binding;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0043186,cellular_component,P granule;GO:0043488,biological_process,regulation of mRNA stability","-"]
["HIP1R",9.763216337,4.10617384,1.248575957,5.647479813,{"v":3.31e-06,"d":"3.31E-06"},{"v":1.4E-5,"d":"1.40E-05"},"ENSG00000130787","K7CDK7,Huntingtin interacting protein 1 related","XP_016779954.1,huntingtin-interacting protein 1-related protein isoform X2","PF01608,I/LWEQ domain;PF16515,Clathrin-binding domain of Huntingtin-interacting protein 1;PF07651,ANTH domain","IPR035964,I/LWEQ domain superfamily;IPR008942,ENTH/VHS;IPR030224,Sla2 family;IPR030555,Huntingtin-interacting protein 1-related protein;IPR011417,AP180 N-terminal homology (ANTH) domain;IPR032422,Huntingtin-interacting protein 1, clathrin-binding domain;IPR013809,ENTH  domain;IPR002558,I/LWEQ domain","ENOG410XRXQ,-;KOG0980,Actin-binding protein SLA2/Huntingtin-interacting protein Hip1","GO:0072583,biological_process,clathrin-dependent endocytosis;GO:0006915,biological_process,apoptotic process;GO:1901030,biological_process,positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0005856,cellular_component,cytoskeleton;GO:0080025,molecular_function,phosphatidylinositol-3,5-bisphosphate binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0006919,biological_process,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0030276,molecular_function,clathrin binding;GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:0055123,biological_process,digestive system development;GO:0050821,biological_process,protein stabilization;GO:0043325,molecular_function,phosphatidylinositol-3,4-bisphosphate binding;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0032092,biological_process,positive regulation of protein binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0005938,cellular_component,cell cortex;GO:0032587,cellular_component,ruffle membrane;GO:0045742,biological_process,positive regulation of epidermal growth factor receptor signaling pathway;GO:0035615,molecular_function,clathrin adaptor activity;GO:0017124,molecular_function,SH3 domain binding;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0005829,cellular_component,cytosol;GO:0051015,molecular_function,actin filament binding;GO:0042802,molecular_function,identical protein binding;GO:0005739,cellular_component,mitochondrion;GO:0006898,biological_process,receptor-mediated endocytosis;GO:0005546,molecular_function,phosphatidylinositol-4,5-bisphosphate binding;GO:0030100,biological_process,regulation of endocytosis;GO:0034316,biological_process,negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0005905,cellular_component,clathrin-coated pit;GO:0060453,biological_process,regulation of gastric acid secretion;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016324,cellular_component,apical plasma membrane;GO:0003779,molecular_function,actin binding;GO:2000588,biological_process,positive regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0048268,biological_process,clathrin coat assembly;GO:0030136,cellular_component,clathrin-coated vesicle;GO:1905445,biological_process,positive regulation of clathrin coat assembly;GO:0005547,molecular_function,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0061024,biological_process,membrane organization;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0005543,molecular_function,phospholipid binding;GO:0032051,molecular_function,clathrin light chain binding;GO:0030837,biological_process,negative regulation of actin filament polymerization;GO:0006897,biological_process,endocytosis;GO:0043065,biological_process,positive regulation of apoptotic process","-"]
["MTFR1",16.82586469,7.078493089,1.248289179,5.812659515,{"v":2.12E-6,"d":"2.12E-06"},{"v":9.37e-06,"d":"9.37E-06"},"ENSG00000066855","A0A024R7W1,Mitochondrial fission regulator 1, isoform CRA_a","NP_055452.3,mitochondrial fission regulator 1 isoform 1","PF05308,Mitochondrial fission regulator","IPR007972,Mitochondrial fission regulator 1","ENOG410IEID,-;ENOG4111K5H,-","GO:0005829,cellular_component,cytosol;GO:0009060,biological_process,aerobic respiration;GO:0005739,cellular_component,mitochondrion","-"]
["PPFIA1",49.887729,21.00527101,1.24780285,8.538887079,{"v":8.09E-9,"d":"8.09E-09"},{"v":6.07e-08,"d":"6.07E-08"},"ENSG00000131626","G3RBT5,PTPRF interacting protein alpha 1","XP_004051749.1,liprin-alpha-1 isoform X7","PF00536,SAM domain (Sterile alpha motif);PF07647,SAM domain (Sterile alpha motif)","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR029515,LAR-interacting protein, Liprin;IPR037622,Liprin-alpha, SAM domain repeat 3;IPR001660,Sterile alpha motif domain;IPR030438,Liprin-alpha-1;IPR037621,Liprin-alpha, SAM domain repeat 2;IPR037620,Liprin-alpha, SAM domain repeat 1","-","-","-"]
["DDX47",18.37489219,7.736498009,1.247246339,6.059304596,{"v":9.28e-07,"d":"9.28E-07"},{"v":4.41e-06,"d":"4.41E-06"},"ENSG00000213782","A0A024RAS3,HCG27698, isoform CRA_a","NP_057439.2,probable ATP-dependent RNA helicase DDX47 isoform 1","PF00271,Helicase conserved C-terminal domain;PF00270,AD/DEAH box helicase","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR014014,RNA helicase, DEAD-box type, Q motif;IPR011545,DEAD/DEAH box helicase domain;IPR000629,ATP-dependent RNA helicase DEAD-box, conserved site;IPR001650,Helicase, C-terminal","ENOG410XQU7,-;KOG0330,ATP-dependent RNA helicase","GO:0016787,molecular_function,hydrolase activity;GO:0005730,cellular_component,nucleolus;GO:0003676,molecular_function,nucleic acid binding;GO:0004386,molecular_function,helicase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["FAM60A",10.8236879,4.560381977,1.245870366,5.494560523,{"v":5.48E-6,"d":"5.48E-06"},{"v":2.21e-05,"d":"2.21E-05"},"ENSG00000139146","H9Z1J6,Family with sequence similarity 60, member A","XP_015006873.1,-;XP_015006870.1,-;XP_015006871.1,-;XP_015006874.1,-;XP_015006872.1,-;XP_015006869.1,-","-","IPR026065,SIN3-HDAC complex-associated factor","ENOG4111PRH,-;ENOG410IKPK,-","-","-"]
["GPR39",3.225027069,1.354380936,1.245431938,3.088780135,0.009134047,0.017578834,"ENSG00000183840","B3KV24,cDNA FLJ16071 fis, clone HSYRA2001003, highly similar to Probable G-protein coupled receptor 39","-","PF00001,7 transmembrane receptor (rhodopsin family)","IPR017452,GPCR, rhodopsin-like, 7TM;IPR000276,G protein-coupled receptor, rhodopsin-like","ENOG410XRW9,-;KOG3656,FOG: 7 transmembrane receptor","GO:0016020,cellular_component,membrane;GO:0004871,molecular_function,signal transducer activity;GO:0007165,biological_process,signal transduction;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016021,cellular_component,integral component of membrane","-"]
["RP11-360L9.8",14.98376774,6.292576449,1.245431938,3.088780135,0.009134047,0.017578834,"ENSG00000264578","A0A0C5CQS7,LPAAT-zeta protein","-","PF01553,Acyltransferase","IPR002123,Phospholipid/glycerol acyltransferase","-","GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016021,cellular_component,integral component of membrane;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane","-"]
["HIF1AN",6.962093148,2.936052375,1.244942714,6.127744228,{"v":7.98e-07,"d":"7.98E-07"},{"v":3.85e-06,"d":"3.85E-06"},"ENSG00000166135","F7H440,Hypoxia inducible factor 1 alpha subunit inhibitor","XP_015003440.1,-","PF13621,Cupin-like domain","IPR027445,Hypoxia-inducible factor 1-alpha inhibitor;IPR027452,Hypoxia-inducible factor 1-alpha inhibitor, domain II;IPR003347,JmjC domain","KOG2132,Uncharacterized conserved protein, contains JmjC domain;ENOG410XQDR,-","GO:0045663,biological_process,positive regulation of myoblast differentiation;GO:0051059,molecular_function,NF-kappaB binding;GO:0042265,biological_process,peptidyl-asparagine hydroxylation;GO:0036138,biological_process,peptidyl-histidine hydroxylation;GO:0005506,molecular_function,iron ion binding;GO:0005112,molecular_function,Notch binding;GO:0005634,cellular_component,nucleus;GO:0048037,molecular_function,cofactor binding;GO:0061428,biological_process,negative regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0042264,biological_process,peptidyl-aspartic acid hydroxylation;GO:0036139,molecular_function,peptidyl-histidine dioxygenase activity;GO:0031406,molecular_function,carboxylic acid binding;GO:0071532,molecular_function,ankyrin repeat binding;GO:0005829,cellular_component,cytosol;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm;GO:0036140,molecular_function,peptidyl-asparagine 3-dioxygenase activity;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0045746,biological_process,negative regulation of Notch signaling pathway;GO:0055114,biological_process,oxidation-reduction process","-"]
["ITPK1",4.58606502,1.932262687,1.244777202,4.51989086,1.25699E-4,0.000372124,"ENSG00000100605","A0A024R6H3,Inositol 1,3,4-triphosphate 5/6 kinase, isoform CRA_a","NP_001136065.1,-;NP_055031.2,inositol-tetrakisphosphate 1-kinase isoform a","PF05770,Inositol 1, 3, 4-trisphosphate 5/6-kinase","IPR008656,Inositol-tetrakisphosphate 1-kinase;IPR011761,ATP-grasp fold","ENOG410IHA6,-;ENOG4110KIK,-","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0052725,molecular_function,inositol-1,3,4-trisphosphate 6-kinase activity;GO:0032957,biological_process,inositol trisphosphate metabolic process;GO:0046872,molecular_function,metal ion binding;GO:0047325,molecular_function,inositol tetrakisphosphate 1-kinase activity;GO:0016324,cellular_component,apical plasma membrane;GO:0000287,molecular_function,magnesium ion binding;GO:0005622,cellular_component,intracellular;GO:0052726,molecular_function,inositol-1,3,4-trisphosphate 5-kinase activity;GO:0021915,biological_process,neural tube development;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","K00913,ko00562,Inositol phosphate metabolism;K00913,ko04070,Phosphatidylinositol signaling system"]
["ANKRD18B",2.392034928,1.00699027,1.243333715,3.423327226,4.406531E-3,0.009171534,"ENSG00000230453","H2R1Q8,Uncharacterized protein","-","PF12796,Ankyrin repeats (3 copies);PF13857,Ankyrin repeats (many copies);PF12001,omain of unknown function (DUF3496);PF14915,CCDC144C protein coiled-coil region","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR021885,Protein of unknown function DUF3496;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","-","-"]
["RP11-473I1.9",4.84379946,2.044456341,1.242739963,4.885229866,{"v":4.99E-5,"d":"4.99E-05"},0.000161496,"ENSG00000263244","F7I4T2,Latent transforming growth factor beta binding protein 4","-","-","-","-","-","-"]
["MTERF4",1.720379398,0.725356791,1.24199326,3.694147222,2.317483E-3,0.00517702,"ENSG00000122085","H2QJR2,Mitochondrial transcription termination factor 4","-","PF02536,mTERF","IPR038538,MTERF superfamily, mitochondrial/chloroplastic","ENOG410Y0Q1,-;ENOG410IK50,-","GO:0019843,molecular_function,rRNA binding;GO:0032502,biological_process,developmental process;GO:0042255,biological_process,ribosome assembly;GO:0003727,molecular_function,single-stranded RNA binding;GO:0008380,biological_process,RNA splicing","-"]
["PSMD2",89.66265159,37.91594239,1.241563987,8.446059646,{"v":1.04E-8,"d":"1.04E-08"},{"v":7.65e-08,"d":"7.65E-08"},"ENSG00000175166","H2QNV3,Proteasome","XP_001147451.2,-","PF01851,Proteasome/cyclosome repeat","IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR002015,Proteasome/cyclosome repeat;IPR016643,26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit","COG5110,26S proteasome regulatory complex component;KOG2005,26S proteasome regulatory complex, subunit RPN1/PSMD2","GO:0004175,molecular_function,endopeptidase activity;GO:0000502,cellular_component,proteasome complex;GO:0034515,cellular_component,proteasome storage granule;GO:0042176,biological_process,regulation of protein catabolic process;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050790,biological_process,regulation of catalytic activity;GO:0030234,molecular_function,enzyme regulator activity;GO:0008540,cellular_component,proteasome regulatory particle, base subcomplex;GO:0005634,cellular_component,nucleus","K03028,ko03050,Proteasome;K03028,ko05169,Epstein-Barr virus infection"]
["CYB5RL",2.261271829,0.954430828,1.24106286,3.921745343,0.001307757,3.066549E-3,"ENSG00000215883","H2PZ31,Cytochrome b5 reductase-like","XP_513422.3,NADH-cytochrome b5 reductase-like isoform X2","PF00175,Oxidoreductase NAD-binding domain;PF09791,Oxidoreductase-like protein, N-terminal;PF00970,Oxidoreductase FAD-binding domain","IPR017927,Ferredoxin reductase-type FAD-binding domain;IPR017938,Riboflavin synthase-like beta-barrel;IPR019180,Oxidoreductase-like, N-terminal;IPR001834,NADH:cytochrome b5 reductase (CBR);IPR001433,Oxidoreductase FAD/NAD(P)-binding;IPR008333,Oxidoreductase, FAD-binding domain","KOG0534,NADH-cytochrome b-5 reductase;COG0543,2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["TRIM44",15.87062529,6.715133691,1.240544811,7.215073461,{"v":6.59e-08,"d":"6.59E-08"},{"v":4.03E-7,"d":"4.03E-07"},"ENSG00000166326","H2Q3F0,Tripartite motif containing 44","XP_508888.2,-","PF00643,B-box zinc finger","IPR000315,B-box-type zinc finger","ENOG410IPQC,-;ENOG4111H1M,-","GO:1901224,biological_process,positive regulation of NIK/NF-kappaB signaling;GO:0001961,biological_process,positive regulation of cytokine-mediated signaling pathway;GO:0050821,biological_process,protein stabilization;GO:0061944,biological_process,negative regulation of protein K48-linked ubiquitination;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0002230,biological_process,positive regulation of defense response to virus by host;GO:0005622,cellular_component,intracellular;GO:0010468,biological_process,regulation of gene expression;GO:0008270,molecular_function,zinc ion binding","-"]
["GALE",5.849948275,2.471066705,1.24037932,4.118077074,0.000446108,1.164513E-3,"ENSG00000117308","H2PYB2,UDP-galactose-4-epimerase","XP_016811766.1,-;XP_016811762.1,-;XP_016811759.1,-","PF08659,KR domain;PF07993,Male sterility protein;PF01370,NAD dependent epimerase/dehydratase family;PF02719,Polysaccharide biosynthesis protein;PF01073,3-beta hydroxysteroid dehydrogenase/isomerase family;PF04321,RmlD substrate binding domain;PF16363,P-mannose 4,6 dehydratase","IPR005886,UDP-glucose 4-epimerase;IPR036291,NAD(P)-binding domain superfamily;IPR008089,Nucleotide sugar epimerase;IPR016040,NAD(P)-binding domain","COG1087,UDP-glucose 4-epimerase;KOG1371,UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase","GO:0005975,biological_process,carbohydrate metabolic process;GO:0006012,biological_process,galactose metabolic process;GO:0019388,biological_process,galactose catabolic process;GO:0042803,molecular_function,protein homodimerization activity;GO:0003978,molecular_function,UDP-glucose 4-epimerase activity;GO:0016853,molecular_function,isomerase activity;GO:0042802,molecular_function,identical protein binding;GO:0016857,molecular_function,racemase and epimerase activity, acting on carbohydrates and derivatives","K01784,ko00520,Amino sugar and nucleotide sugar metabolism;K01784,ko00052,Galactose metabolism"]
["ZNF460",7.520135842,3.178475644,1.239855898,4.290728384,0.000289049,0.000790412,"ENSG00000197714","G3SJ89,Zinc finger protein 460","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","-","-","-","-"]
["FEM1C",5.062767884,2.140854696,1.239442232,4.444816888,0.000194734,0.00055496,"ENSG00000145780","A0A0D9RQR9,Fem-1 homolog C","XP_008012373.1,-","PF12796,Ankyrin repeats (3 copies);PF13857,Ankyrin repeats (many copies);PF13637,Ankyrin repeats (many copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily","-","GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm","-"]
["TAF9",25.5244316,10.80768057,1.238794784,5.575472557,{"v":4.73e-06,"d":"4.73E-06"},{"v":1.94e-05,"d":"1.94E-05"},"ENSG00000273841","A0A0D9SC11,TATA-box binding protein associated factor 9","XP_007970119.1,transcription initiation factor TFIID subunit 9","PF02291,Transcription initiation factor IID, 31kD subunit","IPR003162,Transcription initiation factor TAFII31;IPR009072,Histone-fold","-","GO:0006352,biological_process,DNA-templated transcription, initiation;GO:0046982,molecular_function,protein heterodimerization activity","K14535,ko03022,Basal transcription factors"]
["MSANTD3",13.79648554,5.842139506,1.23822753,5.035467723,{"v":2.74e-05,"d":"2.74E-05"},{"v":9.46e-05,"d":"9.46E-05"},"ENSG00000066697","G3RV78,Uncharacterized protein","XP_018889466.1,-;XP_004048410.2,-;XP_004048409.2,myb/SANT-like DNA-binding domain-containing protein 3 isoform X2","PF13873,Myb/SANT-like DNA-binding domain","IPR028002,Myb/SANT-like DNA-binding domain;IPR026709,Myb/SANT-like DNA-binding domain-containing protein 3","-","-","-"]
["CLSTN3",1.245238926,0.525025185,1.23804923,2.7668401,0.029430716,0.049511657,"ENSG00000139182","B4DRB1,cDNA FLJ50735, highly similar to Calsyntenin-3","-","PF00028,Cadherin domain","IPR002126,Cadherin;IPR015919,Cadherin-like;IPR026914,Calsyntenin;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily","ENOG410XT2J,-;KOG1834,Calsyntenin","GO:0005509,molecular_function,calcium ion binding;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["LYRM4",0.905280656,0.381689918,1.23804923,2.7668401,0.029430716,0.049511657,"ENSG00000214113","F5H189,LYR motif-containing protein 4","NP_001158312.1,LYR motif-containing protein 4 isoform 2","PF05347,Complex 1 protein (LYR family)","IPR008011,Complex 1 LYR protein","KOG3801,Uncharacterized conserved protein BCN92;ENOG41124X5,-","-","-"]
["CRLS1",2.166768551,0.91526102,1.237483146,3.175108111,0.008262948,0.016075389,"ENSG00000088766","G3RD74,Cardiolipin synthase 1","XP_004061837.1,-","PF01066,CDP-alcohol phosphatidyltransferase","IPR000462,CDP-alcohol phosphatidyltransferase","-","GO:0008654,biological_process,phospholipid biosynthetic process;GO:0016780,molecular_function,phosphotransferase activity, for other substituted phosphate groups;GO:0005739,cellular_component,mitochondrion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K08744,ko00564,Glycerophospholipid metabolism"]
["RPP14",1.389484968,0.586929983,1.237483146,3.175108111,0.008262948,0.016075389,"ENSG00000163684","H2QMU9,Ribonuclease P/MRP subunit p14","-","PF01900,Rpp14/Pop5 family","-","-","-","-"]
["ARPC5L",19.27308104,8.168894753,1.237405042,5.655522277,{"v":4.13e-06,"d":"4.13E-06"},{"v":1.71e-05,"d":"1.71E-05"},"ENSG00000136950","F7EX37,Actin-related protein 2/3 complex subunit 5","XP_002743354.3,-","PF04699,ARP2/3 complex 16 kDa subunit (p16-Arc)","IPR006789,Actin-related protein 2/3 complex subunit 5;IPR030075,Actin-related protein 2/3 complex subunit 5-like protein;IPR036743,Actin-related protein 2/3 complex subunit 5 superfamily","KOG3380,Actin-related protein Arp2/3 complex, subunit ARPC5;ENOG4111FGV,-","GO:0005856,cellular_component,cytoskeleton;GO:0015629,cellular_component,actin cytoskeleton;GO:0030833,biological_process,regulation of actin filament polymerization;GO:0034314,biological_process,Arp2/3 complex-mediated actin nucleation;GO:0005885,cellular_component,Arp2/3 protein complex","K05754,ko04810,Regulation of actin cytoskeleton;K05754,ko05132,Salmonella infection;K05754,ko05100,Bacterial invasion of epithelial cells;K05754,ko04144,Endocytosis;K05754,ko05130,Pathogenic Escherichia coli infection;K05754,ko05131,Shigellosis;K05754,ko04666,Fc gamma R-mediated phagocytosis"]
["DPYSL2",2.015404382,0.85223894,1.237154,3.492045962,0.003161754,0.006791525,"ENSG00000092964","K6ZQM1,Dihydropyrimidinase-like 2","XP_001161598.2,-","PF01979,Amidohydrolase family","IPR011778,Hydantoinase/dihydropyrimidinase;IPR006680,Amidohydrolase-related;IPR032466,Metal-dependent hydrolase;IPR011059,Metal-dependent hydrolase, composite domain superfamily;IPR030615,Dihydropyrimidinase-related protein 2","KOG2584,Dihydroorotase and related enzymes;COG0044,Dihydroorotase and related cyclic amidohydrolases","GO:0005829,cellular_component,cytosol;GO:0019901,molecular_function,protein kinase binding;GO:0007010,biological_process,cytoskeleton organization;GO:0010975,biological_process,regulation of neuron projection development;GO:0030425,cellular_component,dendrite;GO:0043209,cellular_component,myelin sheath;GO:0005737,cellular_component,cytoplasm;GO:0007411,biological_process,axon guidance;GO:0043025,cellular_component,neuronal cell body;GO:0016810,molecular_function,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0016787,molecular_function,hydrolase activity;GO:0005886,cellular_component,plasma membrane;GO:0005739,cellular_component,mitochondrion;GO:0045664,biological_process,regulation of neuron differentiation;GO:0008017,molecular_function,microtubule binding;GO:0007420,biological_process,brain development;GO:0030424,cellular_component,axon;GO:0030516,biological_process,regulation of axon extension","K07528,ko04360,Axon guidance"]
["CBX8",4.277019908,1.809860528,1.236938779,3.751245619,0.001712831,3.9305E-3,"ENSG00000141570","G3QPR3,Chromobox 8","XP_004040899.1,chromobox protein homolog 8","PF00385,Chromo (CHRromatin Organisation MOdifier) domain;PF17218,CBX family C-terminal motif","IPR000953,Chromo/chromo shadow domain;IPR016197,Chromo-like domain superfamily;IPR023779,Chromo domain, conserved site;IPR023780,Chromo domain;IPR033773,CBX family C-terminal motif","-","GO:0000792,cellular_component,heterochromatin;GO:0003727,molecular_function,single-stranded RNA binding;GO:0035064,molecular_function,methylated histone binding;GO:0035102,cellular_component,PRC1 complex;GO:0097027,molecular_function,ubiquitin-protein transferase activator activity;GO:0000151,cellular_component,ubiquitin ligase complex;GO:0050790,biological_process,regulation of catalytic activity;GO:0016574,biological_process,histone ubiquitination;GO:0000790,cellular_component,nuclear chromatin;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0031519,cellular_component,PcG protein complex;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["DGUOK",14.36185071,6.080352589,1.23678706,3.970597326,0.000990729,0.002396124,"ENSG00000114956","E5KSL5,Deoxyguanosine kinase isoform 1","NP_550438.1,deoxyguanosine kinase, mitochondrial isoform a precursor","PF01712,eoxynucleoside kinase","IPR002624,Deoxynucleoside kinase;IPR031314,Deoxynucleoside kinase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1428,Deoxynucleoside kinases;KOG4235,Mitochondrial thymidine kinase 2/deoxyguanosine kinase","GO:0016301,molecular_function,kinase activity;GO:0010977,biological_process,negative regulation of neuron projection development;GO:0009157,biological_process,deoxyribonucleoside monophosphate biosynthetic process;GO:0005737,cellular_component,cytoplasm;GO:0019206,molecular_function,nucleoside kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0009165,biological_process,nucleotide biosynthetic process;GO:0016310,biological_process,phosphorylation;GO:0005739,cellular_component,mitochondrion;GO:0005829,cellular_component,cytosol;GO:0004138,molecular_function,deoxyguanosine kinase activity;GO:0046070,biological_process,dGTP metabolic process;GO:0005524,molecular_function,ATP binding;GO:0006139,biological_process,nucleobase-containing compound metabolic process","K00904,ko00230,Purine metabolism"]
["SMN1",11.73115991,4.972612825,1.236414903,4.739211985,{"v":8.02e-05,"d":"8.02E-05"},0.000247606,"ENSG00000172062","H2QR14,Survival of motor neuron 1, telomeric","-","PF06003,Survival motor neuron protein (SMN)","IPR002999,Tudor domain;IPR010304,Survival motor neuron","KOG4327,mRNA splicing protein SMN (survival motor neuron);ENOG4111ME8,-","GO:0005737,cellular_component,cytoplasm;GO:0003723,molecular_function,RNA binding;GO:0006397,biological_process,mRNA processing;GO:0005634,cellular_component,nucleus","-"]
["ZFC3H1",6.630221223,2.812416333,1.236196373,5.539932733,{"v":6.04e-06,"d":"6.04E-06"},{"v":2.42e-05,"d":"2.42E-05"},"ENSG00000133858","H2R788,Zinc finger, C3H1-type containing","XP_509222.2,zinc finger C3H1 domain-containing protein","PF10650,Putative zinc-finger domain","IPR019607,Putative zinc-finger domain;IPR003107,HAT (Half-A-TPR) repeat;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR013026,Tetratricopeptide repeat-containing domain","KOG4839,Uncharacterized conserved protein;ENOG410XQ07,-","GO:0000178,cellular_component,exosome (RNase complex);GO:0005634,cellular_component,nucleus;GO:0006396,biological_process,RNA processing","-"]
["PCYT1A",20.50765105,8.707025615,1.235499174,6.875693055,{"v":1.51e-07,"d":"1.51E-07"},{"v":8.51e-07,"d":"8.51E-07"},"ENSG00000161217","C9JEJ2,Choline-phosphate cytidylyltransferase A","-","PF01467,Cytidylyltransferase-like","IPR004821,Cytidyltransferase-like domain;IPR014729,Rossmann-like alpha/beta/alpha sandwich fold","COG0615,Cytidylyltransferase;KOG2804,Phosphorylcholine transferase/cholinephosphate cytidylyltransferase","GO:0003824,molecular_function,catalytic activity;GO:0009058,biological_process,biosynthetic process","-"]
["2020-09-09",19.04266192,8.086990976,1.23528527,7.452267802,{"v":4.54e-08,"d":"4.54E-08"},{"v":2.88e-07,"d":"2.88E-07"},"ENSG00000184640","G7NGZ3,Uncharacterized protein","-","PF00735,Septin","IPR030379,Septin-type guanine nucleotide-binding (G) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR030645,Septin 9;IPR016491,Septin","-","GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding","-"]
["KIAA1671",5.821305344,2.471577784,1.235207525,6.109496077,{"v":1.04E-6,"d":"1.04E-06"},{"v":4.88e-06,"d":"4.88E-06"},"ENSG00000197077","G3R710,KIAA1671","XP_018874198.1,uncharacterized protein KIAA1671 homolog","PF15327,Tankyrase binding protein C terminal domain","IPR032764,Tankyrase 1-binding protein, C-terminal","-","-","-"]
["SEPHS2",21.78191846,9.248047058,1.234700432,5.337791739,{"v":9.72e-06,"d":"9.72E-06"},{"v":3.7e-05,"d":"3.70E-05"},"ENSG00000179918","F7HQM6,Uncharacterized protein","-","PF02769,AIR synthase related protein, C-terminal domain;PF00586,AIR synthase related protein, N-terminal domain","IPR036676,PurM-like, C-terminal domain superfamily;IPR004536,Selenophosphate synthetase;IPR036921,PurM-like, N-terminal domain superfamily;IPR010918,PurM-like, C-terminal domain;IPR016188,PurM-like, N-terminal domain;IPR023061,Selenophosphate synthetase, class I","COG0709,Selenophosphate synthase;KOG3939,Selenophosphate synthetase","GO:0004756,molecular_function,selenide, water dikinase activity;GO:0001887,biological_process,selenium compound metabolic process;GO:0016310,biological_process,phosphorylation;GO:0016260,biological_process,selenocysteine biosynthetic process;GO:0005524,molecular_function,ATP binding","-"]
["PPHLN1",3.047616838,1.293940384,1.234096399,4.767066789,{"v":7.8e-05,"d":"7.80E-05"},0.000241718,"ENSG00000134283","G3RPG7,Periphilin 1","-","PF11488,Transcriptional regulatory protein LGE1","IPR028851,Periphilin-1","-","GO:0005829,cellular_component,cytosol;GO:0005794,cellular_component,Golgi apparatus;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0005654,cellular_component,nucleoplasm","-"]
["ARHGEF16",4.994218407,2.120417764,1.233492992,4.365593088,0.00030684,0.000832476,"ENSG00000130762","B3KTS4,cDNA FLJ38665 fis, clone HLUNG2003378, highly similar to Rho guanine nucleotide exchange factor 16","NP_055263.2,rho guanine nucleotide exchange factor 16","PF14604,Variant SH3 domain;PF00621,RhoGEF domain;PF00169,PH domain","IPR035797,ARHGEF16/ARHGEF26, SH3 domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR036028,SH3-like domain superfamily;IPR035899,Dbl homology (DH) domain superfamily;IPR001452,SH3 domain;IPR000219,Dbl homology (DH) domain","COG5422,RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases;KOG3523,Putative guanine nucleotide exchange factor TIM","GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function","-"]
["OSBP2",20.23727507,8.607278557,1.232891338,6.607633691,{"v":2.83e-07,"d":"2.83E-07"},{"v":1.49e-06,"d":"1.49E-06"},"ENSG00000184792","G3RRY3,Oxysterol-binding protein","XP_018874105.1,-;XP_018874104.1,oxysterol-binding protein 2 isoform X6","PF01237,Oxysterol-binding protein;PF00169,PH domain","IPR000648,Oxysterol-binding protein;IPR018494,Oxysterol-binding protein, conserved site;IPR037239,Oxysterol-binding protein superfamily","-","GO:0006869,biological_process,lipid transport","-"]
["BDNF",2.393009216,1.016010682,1.232288052,3.806156308,1.598246E-3,0.003688066,"ENSG00000176697","G3S0L4,Brain-derived neurotrophic factor","-","PF00243,Nerve growth factor family","-","-","-","-"]
["HNRNPL",21.89743899,9.319265261,1.232025473,6.746280331,{"v":1.95e-07,"d":"1.95E-07"},{"v":1.07e-06,"d":"1.07E-06"},"ENSG00000104824","H2QG92,Heterogeneous nuclear ribonucleoprotein L","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF13893,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034816,hnRNP-L, RNA recognition motif 3;IPR034817,hnRNP-L, RNA recognition motif 4;IPR035005,hnRNP-L, RNA recognition motif 1;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR035008,hnRNP-L, RNA recognition motif 2;IPR006536,HnRNP-L/PTB","KOG1456,Heterogeneous nuclear ribonucleoprotein L (contains RRM repeats);ENOG410XQHN,-","GO:0000381,biological_process,regulation of alternative mRNA splicing, via spliceosome;GO:0097157,molecular_function,pre-mRNA intronic binding;GO:0006397,biological_process,mRNA processing;GO:0003723,molecular_function,RNA binding;GO:0035770,cellular_component,ribonucleoprotein granule;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005634,cellular_component,nucleus;GO:0030529,,;GO:0005654,cellular_component,nucleoplasm","-"]
["ATF7",4.731348759,2.011968522,1.231868818,4.794392902,{"v":6.45e-05,"d":"6.45E-05"},2.0384E-4,"ENSG00000170653","G3RGS2,Activating transcription factor 7","XP_018894489.1,-;XP_004053287.1,-","PF00170,bZIP transcription factor","IPR013087,Zinc finger C2H2-type;IPR016378,Transcription factor cyclic AMP-dependent, CRE-BP1-type;IPR036236,Zinc finger C2H2 superfamily;IPR004827,Basic-leucine zipper domain","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity","-"]
["ZNF710",3.127007586,1.327647671,1.231566285,3.557615431,0.00291919,0.006316016,"ENSG00000140548","H2QA28,Zinc finger protein 710","-","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["SLC3A2",33.56910513,14.30126276,1.230606769,6.96384195,{"v":1.29E-7,"d":"1.29E-07"},{"v":7.36e-07,"d":"7.36E-07"},"ENSG00000168003","J3KPF3,4F2 cell-surface antigen heavy chain","NP_001012680.1,4F2 cell-surface antigen heavy chain isoform b","PF16028,Solute carrier family 3 member 2 N-terminus;PF00128,Alpha amylase, catalytic domain","IPR017853,Glycoside hydrolase superfamily;IPR006047,Glycosyl hydrolase, family 13, catalytic domain;IPR031984,Solute carrier family 3 member 2, N-terminal domain;IPR013780,Glycosyl hydrolase, all-beta","COG0366,Glycosidases;KOG0471,Alpha-amylase","GO:0005975,biological_process,carbohydrate metabolic process;GO:0003824,molecular_function,catalytic activity;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane","-"]
["SEC14L2",2.06314579,0.875959085,1.230485314,3.256513436,0.008781508,0.016997933,"ENSG00000100003","A0A024R1I5,SEC14-like 2","NP_036561.1,SEC14-like protein 2 isoform 1","PF00650,CRAL/TRIO domain","IPR009038,GOLD domain;IPR001251,CRAL-TRIO lipid binding domain;IPR036273,CRAL/TRIO, N-terminal domain superfamily;IPR036598,GOLD domain superfamily;IPR011074,CRAL/TRIO, N-terminal domain;IPR036865,CRAL-TRIO lipid binding domain superfamily","KOG1471,Phosphatidylinositol transfer protein SEC14 and related proteins;ENOG410XRSQ,-","GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["PDS5A",9.767698536,4.161572762,1.230328906,6.424320028,{"v":4.26e-07,"d":"4.26E-07"},{"v":2.17E-6,"d":"2.17E-06"},"ENSG00000121892","G1UI16,SCC-112 protein, isoform CRA_b","NP_001093869.1,sister chromatid cohesion protein PDS5 homolog A isoform 1;XP_016863417.1,-;XP_011511974.1,-","-","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","KOG1525,Sister chromatid cohesion complex Cohesin, subunit PDS5;ENOG410XQW7,-","GO:0005886,cellular_component,plasma membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["CPEB4",2.47354318,1.052657096,1.229911424,4.242531974,0.000448026,0.00116857,"ENSG00000113742","H2PHE6,Cytoplasmic polyadenylation element binding protein 4","-","PF16366,Cytoplasmic polyadenylation element-binding protein ZZ domain;PF16367,RNA recognition motif","IPR038446,CEBP, ZZ domain superfamily;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR032296,Cytoplasmic polyadenylation element-binding protein, ZZ domain;IPR000504,RNA recognition motif domain;IPR034819,Cytoplasmic polyadenylation element-binding protein","KOG0129,Predicted RNA-binding protein (RRM superfamily);ENOG410Y1XZ,-","GO:0002931,biological_process,response to ischemia;GO:0003723,molecular_function,RNA binding;GO:0030425,cellular_component,dendrite;GO:0003730,molecular_function,mRNA 3'-UTR binding;GO:0005737,cellular_component,cytoplasm;GO:0006417,biological_process,regulation of translation;GO:0005783,cellular_component,endoplasmic reticulum;GO:0071230,biological_process,cellular response to amino acid stimulus;GO:0014069,cellular_component,postsynaptic density;GO:0045182,molecular_function,translation regulator activity;GO:0003676,molecular_function,nucleic acid binding;GO:0045202,cellular_component,synapse;GO:0005634,cellular_component,nucleus","-"]
["VPS26A",13.58818223,5.790405902,1.22923724,5.145614306,{"v":2.47e-05,"d":"2.47E-05"},{"v":8.61e-05,"d":"8.61E-05"},"ENSG00000122958","H2Q203,Vacuolar protein sorting 26 homolog A","NP_001316541.1,-","PF03643,Vacuolar protein sorting-associated protein 26","IPR014752,Arrestin, C-terminal;IPR028934,Vacuolar protein sorting protein 26 related","ENOG410XSI1,-;KOG3063,Membrane coat complex Retromer, subunit VPS26","GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0005768,cellular_component,endosome;GO:0030904,cellular_component,retromer complex;GO:0008565,molecular_function,protein transporter activity;GO:0005829,cellular_component,cytosol;GO:0007165,biological_process,signal transduction;GO:0006886,biological_process,intracellular protein transport","K18466,ko04144,Endocytosis"]
["RP11-49K24.6",75.84429389,32.32799876,1.228784511,5.052951669,{"v":3.12e-05,"d":"3.12E-05"},1.05857E-4,"ENSG00000267228","A0A286XD71,Uncharacterized protein","XP_003474106.1,-","-","IPR013880,Yos1-like","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TGFB2",1.797892772,0.763339418,1.228688157,2.874263273,0.019707618,0.034616316,"ENSG00000092969","G1RVC4,Transforming growth factor beta 2","XP_012362112.1,-;XP_003265140.1,-","PF00019,Transforming growth factor beta like domain;PF00688,TGF-beta propeptide","IPR017948,Transforming growth factor beta, conserved site;IPR001111,TGF-beta, propeptide;IPR029034,Cystine-knot cytokine;IPR016319,Transforming growth factor-beta;IPR015615,Transforming growth factor-beta-related;IPR001839,Transforming growth factor-beta, C-terminal;IPR003940,Transforming growth factor, beta 2","ENOG410XT8Z,-;KOG3900,Transforming growth factor beta, bone morphogenetic protein and related proteins","GO:0045778,biological_process,positive regulation of ossification;GO:0008083,molecular_function,growth factor activity;GO:0031012,cellular_component,extracellular matrix;GO:0001942,biological_process,hair follicle development;GO:0060389,biological_process,pathway-restricted SMAD protein phosphorylation;GO:0045216,biological_process,cell-cell junction organization;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0051891,biological_process,positive regulation of cardioblast differentiation;GO:0030199,biological_process,collagen fibril organization;GO:0003007,biological_process,heart morphogenesis;GO:0005114,molecular_function,type II transforming growth factor beta receptor binding;GO:1902895,biological_process,positive regulation of pri-miRNA transcription by RNA polymerase II;GO:0051794,biological_process,regulation of timing of catagen;GO:0007435,biological_process,salivary gland morphogenesis;GO:0048566,biological_process,embryonic digestive tract development;GO:0001666,biological_process,response to hypoxia;GO:0010634,biological_process,positive regulation of epithelial cell migration;GO:0001837,biological_process,epithelial to mesenchymal transition;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:0000902,biological_process,cell morphogenesis;GO:0060317,biological_process,cardiac epithelial to mesenchymal transition;GO:0045726,biological_process,positive regulation of integrin biosynthetic process;GO:0045747,biological_process,positive regulation of Notch signaling pathway;GO:0008219,biological_process,cell death;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0043525,biological_process,positive regulation of neuron apoptotic process;GO:0001654,biological_process,eye development;GO:0010629,biological_process,negative regulation of gene expression;GO:0045823,biological_process,positive regulation of heart contraction;GO:0010002,biological_process,cardioblast differentiation;GO:0034714,molecular_function,type III transforming growth factor beta receptor binding;GO:0042493,biological_process,response to drug;GO:0030307,biological_process,positive regulation of cell growth;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0060395,biological_process,SMAD protein signal transduction;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0033630,biological_process,positive regulation of cell adhesion mediated by integrin;GO:0050714,biological_process,positive regulation of protein secretion;GO:0032147,biological_process,activation of protein kinase activity;GO:0032909,biological_process,regulation of transforming growth factor beta2 production;GO:0005102,molecular_function,signaling receptor binding;GO:0030308,biological_process,negative regulation of cell growth;GO:0032874,biological_process,positive regulation of stress-activated MAPK cascade;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0010936,biological_process,negative regulation of macrophage cytokine production;GO:0001540,molecular_function,amyloid-beta binding;GO:0050680,biological_process,negative regulation of epithelial cell proliferation;GO:0060038,biological_process,cardiac muscle cell proliferation;GO:0006468,biological_process,protein phosphorylation;GO:0007507,biological_process,heart development;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0010693,biological_process,negative regulation of alkaline phosphatase activity;GO:0032570,biological_process,response to progesterone;GO:0023014,biological_process,signal transduction by protein phosphorylation;GO:0007050,biological_process,cell cycle arrest;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0051795,biological_process,positive regulation of timing of catagen;GO:0009611,biological_process,response to wounding;GO:0005160,molecular_function,transforming growth factor beta receptor binding;GO:0008347,biological_process,glial cell migration;GO:0042803,molecular_function,protein homodimerization activity;GO:0097191,biological_process,extrinsic apoptotic signaling pathway;GO:0016477,biological_process,cell migration","-"]
["CCDC130",2.800406914,1.188981355,1.228688157,2.874263273,0.019707618,0.034616316,"ENSG00000104957","B3KUZ1,cDNA FLJ40943 fis, clone UTERU2008561","-","PF04502,amily of unknown function (DUF572)","IPR007590,CWC16 protein","KOG2990,C2C2-type Zn-finger protein;COG5134,Uncharacterized conserved protein","-","-"]
["EPN1",12.3340164,5.263893901,1.228133464,7.284483183,{"v":7.22e-08,"d":"7.22E-08"},{"v":4.38e-07,"d":"4.38E-07"},"ENSG00000063245","H2QH77,Uncharacterized protein","-","PF01417,NTH domain","IPR013809,ENTH  domain;IPR003903,Ubiquitin interacting motif;IPR008942,ENTH/VHS","ENOG410XSM0,-;KOG2056,Equilibrative nucleoside transporter protein","GO:0007565,biological_process,female pregnancy;GO:1903671,biological_process,negative regulation of sprouting angiogenesis;GO:0048568,biological_process,embryonic organ development;GO:0001701,biological_process,in utero embryonic development;GO:0007219,biological_process,Notch signaling pathway;GO:0005829,cellular_component,cytosol","-"]
["ADAT1",4.287621883,1.826033466,1.227994538,3.85904128,0.001195009,0.002837309,"ENSG00000065457","B2RBG6,cDNA, FLJ95496, highly similar to Homo sapiens adenosine deaminase, tRNA-specific 1","-","PF02137,Adenosine-deaminase (editase) domain","IPR002466,Adenosine deaminase/editase","KOG2777,tRNA-specific adenosine deaminase 1;ENOG410XT0Z,-","GO:0003723,molecular_function,RNA binding;GO:0004000,molecular_function,adenosine deaminase activity;GO:0006396,biological_process,RNA processing","-"]
["ZFPM2-AS1",8.691491987,3.701575295,1.227994538,3.85904128,0.001195009,0.002837309,"ENSG00000251003","G7PEQ3,Uncharacterized protein","-","-","-","-","-","-"]
["PARP4",8.201748439,3.50298091,1.226014155,5.187418823,{"v":2.09E-5,"d":"2.09E-05"},{"v":7.41e-05,"d":"7.41E-05"},"ENSG00000102699","K7BD72,Poly [ADP-ribose] polymerase","-","PF08487,Vault protein inter-alpha-trypsin domain;PF00092,von Willebrand factor type A domain;PF00644,Poly(ADP-ribose) polymerase catalytic domain;PF00533,BRCA1 C Terminus (BRCT) domain","IPR031273,Poly [ADP-ribose] polymerase 4;IPR036616,Poly(ADP-ribose) polymerase, regulatory domain superfamily;IPR001357,BRCT domain;IPR036465,von Willebrand factor A-like domain superfamily;IPR004102,Poly(ADP-ribose) polymerase, regulatory domain;IPR013694,VIT domain;IPR012317,Poly(ADP-ribose) polymerase, catalytic domain;IPR036420,BRCT domain superfamily;IPR002035,von Willebrand factor, type A","ENOG410XP18,-;KOG1037,NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins","GO:0006471,biological_process,protein ADP-ribosylation;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0003950,molecular_function,NAD+ ADP-ribosyltransferase activity;GO:0016740,molecular_function,transferase activity","-"]
["BNIPL",13.79436529,5.891597214,1.225681081,4.873390989,{"v":5.83e-05,"d":"5.83E-05"},1.8614E-4,"ENSG00000163141","H2R2V1,BCL2 interacting protein like","XP_001170701.1,bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein","PF13716,ivergent CRAL/TRIO domain;PF12496,Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2","IPR022181,Bcl2-/adenovirus E1B 19kDa-interacting protein 2;IPR001251,CRAL-TRIO lipid binding domain;IPR036865,CRAL-TRIO lipid binding domain superfamily","ENOG410IE6U,-;ENOG4111F6D,-","GO:0006915,biological_process,apoptotic process;GO:0040009,biological_process,regulation of growth rate;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus","-"]
["TMEM173",12.15055808,5.191550688,1.225363964,5.097492178,{"v":2.6e-05,"d":"2.60E-05"},{"v":9.02e-05,"d":"9.02E-05"},"ENSG00000184584","H2R3B4,Transmembrane protein 173","XP_001135484.1,stimulator of interferon genes protein isoform X1;XP_016809410.1,-","PF15009,Transmembrane protein 173","IPR029158,Stimulator of interferon genes protein;IPR033952,Stimulator of interferon genes protein, C-terminal;IPR038623,Stimulator of interferon genes protein, C-terminal domain superfamily","ENOG410IH2R,-;ENOG4111M85,-","GO:0051607,biological_process,defense response to virus;GO:0035458,biological_process,cellular response to interferon-beta;GO:0019901,molecular_function,protein kinase binding;GO:0032481,biological_process,positive regulation of type I interferon production;GO:0033160,biological_process,positive regulation of protein import into nucleus, translocation;GO:0005783,cellular_component,endoplasmic reticulum;GO:0002218,biological_process,activation of innate immune response;GO:0008134,molecular_function,transcription factor binding;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0005794,cellular_component,Golgi apparatus;GO:0032608,biological_process,interferon-beta production;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0071360,biological_process,cellular response to exogenous dsRNA;GO:0042993,biological_process,obsolete positive regulation of transcription factor import into nucleus;GO:0002230,biological_process,positive regulation of defense response to virus by host;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0005777,cellular_component,peroxisome;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0071407,biological_process,cellular response to organic cyclic compound;GO:0032092,biological_process,positive regulation of protein binding;GO:0045087,biological_process,innate immune response;GO:0035438,molecular_function,cyclic-di-GMP binding;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0061507,molecular_function,cyclic-GMP-AMP binding","K12654,ko04622,RIG-I-like receptor signaling pathway;K12654,ko04623,Cytosolic DNA-sensing pathway"]
["RAP1GAP",6.395538231,2.732901019,1.224827226,4.760645704,{"v":9.18e-05,"d":"9.18E-05"},0.000279118,"ENSG00000076864","X6R8W7,Rap1 GTPase-activating protein 1","XP_006710867.2,-;XP_016857454.1,-;NP_001317312.1,rap1 GTPase-activating protein 1 isoform d","PF02188,oLoco motif;PF02145,Rap/ran-GAP","IPR003109,GoLoco motif;IPR035974,Rap/Ran-GAP superfamily;IPR000331,Rap GTPase activating protein domain","ENOG410XTIX,-;KOG3686,Rap1-GTPase-activating protein (Rap1GAP)","GO:0030695,molecular_function,GTPase regulator activity;GO:0045665,biological_process,negative regulation of neuron differentiation;GO:0005096,molecular_function,GTPase activator activity;GO:0030425,cellular_component,dendrite;GO:0051056,biological_process,regulation of small GTPase mediated signal transduction;GO:0030424,cellular_component,axon;GO:0043025,cellular_component,neuronal cell body;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0050790,biological_process,regulation of catalytic activity;GO:0005769,cellular_component,early endosome;GO:1904442,biological_process,negative regulation of thyroid gland epithelial cell proliferation;GO:1990792,biological_process,cellular response to glial cell derived neurotrophic factor;GO:0005829,cellular_component,cytosol;GO:0016020,cellular_component,membrane;GO:1904425,biological_process,negative regulation of GTP binding","-"]
["EPHB4",30.59121374,13.08617022,1.224737066,7.143923726,{"v":1.12E-7,"d":"1.12E-07"},{"v":6.49e-07,"d":"6.49E-07"},"ENSG00000196411","H2QV43,EPH receptor B4","XP_016801693.1,-;XP_519269.3,-","PF00536,SAM domain (Sterile alpha motif);PF07714,Protein tyrosine kinase;PF07699,Putative ephrin-receptor like;PF01404,phrin receptor ligand binding domain;PF00041,ibronectin type III domain;PF14575,phrin type-A receptor 2 transmembrane domain","IPR013783,Immunoglobulin-like fold;IPR016257,Ephrin receptor type-A /type-B;IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001090,Ephrin receptor ligand binding domain;IPR036116,Fibronectin type III superfamily;IPR034290,Ephrin type-B receptor 4, ligand binding domain;IPR003961,Fibronectin type III;IPR008979,Galactose-binding-like domain superfamily;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR037636,EPH-B4, SAM domain;IPR020635,Tyrosine-protein kinase, catalytic domain;IPR011641,Tyrosine-protein kinase ephrin type A/B receptor-like;IPR001426,Tyrosine-protein kinase, receptor class V, conserved site;IPR001660,Sterile alpha motif domain;IPR027936,Ephrin receptor, transmembrane domain;IPR000719,Protein kinase domain","COG0515,Serine/threonine protein kinase;KOG0196,Tyrosine kinase, EPH (ephrin) receptor family","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation;GO:0018108,biological_process,peptidyl-tyrosine phosphorylation;GO:0005003,molecular_function,ephrin receptor activity;GO:0048013,biological_process,ephrin receptor signaling pathway;GO:0016740,molecular_function,transferase activity;GO:0007169,biological_process,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0005524,molecular_function,ATP binding;GO:0004713,molecular_function,protein tyrosine kinase activity;GO:0004672,molecular_function,protein kinase activity;GO:0016020,cellular_component,membrane;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["GNG10",13.37803635,5.713782409,1.224018586,3.910045151,0.001307757,3.066549E-3,"ENSG00000242616","K7AE17,Guanine nucleotide-binding protein subunit gamma","NP_001316664.1,-","PF00631,L domain","IPR001770,G-protein, gamma subunit;IPR036284,G-protein gamma-like domain superfamily;IPR015898,G-protein gamma-like domain","ENOG41122JF,-;KOG4119,G protein gamma subunit","GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004871,molecular_function,signal transducer activity;GO:0005834,cellular_component,heterotrimeric G-protein complex;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0007165,biological_process,signal transduction","K04545,ko04713,Circadian entrainment;K04545,ko04014,Ras signaling pathway;K04545,ko04723,Retrograde endocannabinoid signaling;K04545,ko05032,Morphine addiction;K04545,ko04727,GABAergic synapse;K04545,ko04151,PI3K-Akt signaling pathway;K04545,ko04724,Glutamatergic synapse;K04545,ko04062,Chemokine signaling pathway;K04545,ko05200,Pathways in cancer;K04545,ko04725,Cholinergic synapse;K04545,ko04728,Dopaminergic synapse;K04545,ko05034,Alcoholism;K04545,ko04726,Serotonergic synapse"]
["SCNN1A",31.64249383,13.55041136,1.223170174,7.062547854,{"v":1.27e-07,"d":"1.27E-07"},{"v":7.29e-07,"d":"7.29E-07"},"ENSG00000111319","C5HTY8,Amiloride-sensitive sodium channel subunit alpha 1","-","PF00858,Amiloride-sensitive sodium channel","IPR020903,Epithelial sodium channel, conserved site;IPR004724,Epithelial sodium channel, chordates;IPR001873,Epithelial sodium channel","ENOG410ZNFK,-;KOG4294,Non voltage-gated ion channels (DEG/ENaC family)","GO:0006814,biological_process,sodium ion transport;GO:0005272,molecular_function,sodium channel activity;GO:0015280,molecular_function,ligand-gated sodium channel activity;GO:0006811,biological_process,ion transport;GO:0035725,biological_process,sodium ion transmembrane transport;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["LCORL",2.061674434,0.882119922,1.222606178,4.504554466,1.80466E-4,0.000517413,"ENSG00000178177","A0A1B0GVP4,Ligand-dependent nuclear receptor corepressor-like protein","XP_011512124.1,ligand-dependent nuclear receptor corepressor-like protein isoform X2","PF15090,omain of unknown function (DUF4553)","IPR028104,Protein of unknown function DUF4553","-","-","-"]
["ATF2",4.129023566,1.766226186,1.222339735,4.150903258,7.39546E-4,1.838073E-3,"ENSG00000115966","G1R1Z2,Activating transcription factor 2","-","PF00170,bZIP transcription factor","IPR013087,Zinc finger C2H2-type;IPR016378,Transcription factor cyclic AMP-dependent, CRE-BP1-type;IPR036236,Zinc finger C2H2 superfamily;IPR029836,cAMP-dependent transcription factor ATF-2;IPR004827,Basic-leucine zipper domain","KOG1414,Transcriptional activator FOSB/c-Fos and related bZIP transcription factors;ENOG4111CH5,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0005634,cellular_component,nucleus;GO:0003676,molecular_function,nucleic acid binding","K04450,ko04918,Thyroid hormone synthesis;K04450,ko05164,Influenza A;K04450,ko05166,HTLV-I infection;K04450,ko04151,PI3K-Akt signaling pathway;K04450,ko05203,Viral carcinogenesis;K04450,ko04211,Longevity regulating pathway;K04450,ko04922,Glucagon signaling pathway;K04450,ko04010,MAPK signaling pathway;K04450,ko04925,Aldosterone synthesis and secretion;K04450,ko04261,Adrenergic signaling in cardiomyocytes;K04450,ko04728,Dopaminergic synapse;K04450,ko04013,MAPK signaling pathway - fly;K04450,ko05161,Hepatitis B;K04450,ko05169,Epstein-Barr virus infection;K04450,ko05031,Amphetamine addiction;K04450,ko04915,Estrogen signaling pathway;K04450,ko04668,TNF signaling pathway;K04450,ko05034,Alcoholism;K04450,ko04022,cGMP-PKG signaling pathway;K04450,ko05030,Cocaine addiction;K04450,ko04911,Insulin secretion"]
["CCT2",20.16378374,8.642673008,1.221457812,5.980206595,{"v":1.75E-6,"d":"1.75E-06"},{"v":7.89e-06,"d":"7.89E-06"},"ENSG00000166226","H2NI08,Chaperonin containing TCP1 subunit 2","XP_002823555.1,-","PF00118,TCP-1/cpn60 chaperonin family","IPR017998,Chaperone tailless complex polypeptide 1 (TCP-1);IPR012716,T-complex protein 1, beta subunit;IPR027413,GroEL-like equatorial domain superfamily;IPR027409,GroEL-like apical domain superfamily;IPR027410,TCP-1-like chaperonin intermediate domain superfamily;IPR002423,Chaperonin Cpn60/TCP-1 family;IPR002194,Chaperonin TCP-1, conserved site","KOG0363,Chaperonin complex component, TCP-1 beta subunit (CCT2);COG0459,Chaperonin GroEL (HSP60 family)","GO:0051086,biological_process,chaperone mediated protein folding independent of cofactor;GO:0090666,biological_process,scaRNA localization to Cajal body;GO:0051082,molecular_function,unfolded protein binding;GO:0032212,biological_process,positive regulation of telomere maintenance via telomerase;GO:0005524,molecular_function,ATP binding;GO:0051131,biological_process,chaperone-mediated protein complex assembly;GO:0050821,biological_process,protein stabilization;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0006457,biological_process,protein folding;GO:0005829,cellular_component,cytosol;GO:1904851,biological_process,positive regulation of establishment of protein localization to telomere;GO:0007339,biological_process,binding of sperm to zona pellucida;GO:0002199,cellular_component,zona pellucida receptor complex;GO:0044183,molecular_function,protein binding involved in protein folding;GO:0000166,molecular_function,nucleotide binding;GO:0043209,cellular_component,myelin sheath;GO:0005874,cellular_component,microtubule;GO:1904871,biological_process,positive regulation of protein localization to Cajal body;GO:0005832,cellular_component,chaperonin-containing T-complex;GO:0005737,cellular_component,cytoplasm;GO:1904874,biological_process,positive regulation of telomerase RNA localization to Cajal body;GO:0051973,biological_process,positive regulation of telomerase activity;GO:1901998,biological_process,toxin transport;GO:0044297,cellular_component,cell body","-"]
["GTF3C5",29.15365369,12.49718596,1.221441752,6.2419794,{"v":8.44e-07,"d":"8.44E-07"},{"v":4.04e-06,"d":"4.04E-06"},"ENSG00000148308","K7D7A7,General transcription factor IIIC, polypeptide 5, 63kDa","XP_016815838.1,-","PF09734,RNA polymerase III transcription factor (TF)IIIC subunit","IPR019136,Transcription factor IIIC, subunit 5","ENOG4111DXH,-;KOG2473,RNA polymerase III transcription factor (TF)IIIC subunit","-","-"]
["EPB41",3.560022664,1.525577079,1.220801799,4.815029639,{"v":6.29e-05,"d":"6.29E-05"},0.000199305,"ENSG00000159023","H2R0C4,Uncharacterized protein","XP_009450462.1,-;XP_003307976.1,protein 4.1 isoform X14","PF04382,SAB domain;PF05902,4.1 protein C-terminal domain (CTD);PF09380,RM C-terminal PH-like domain;PF09379,RM N-terminal domain;PF08736,RM adjacent (FA);PF00373,RM central domain","IPR019748,FERM central domain;IPR014847,FERM adjacent (FA);IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR019747,FERM conserved site;IPR011993,PH-like domain superfamily;IPR008379,Band 4.1, C-terminal;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR029071,Ubiquitin-like domain superfamily;IPR000798,Ezrin/radixin/moesin-like;IPR007477,SAB domain","ENOG410XS0M,-;ENOG410IU7N,-","GO:0030866,biological_process,cortical actin cytoskeleton organization;GO:1904778,biological_process,positive regulation of protein localization to cell cortex;GO:0008022,molecular_function,protein C-terminus binding;GO:0032991,cellular_component,protein-containing complex;GO:0099738,cellular_component,cell cortex region;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0005198,molecular_function,structural molecule activity;GO:0030054,cellular_component,cell junction;GO:0047485,molecular_function,protein N-terminus binding;GO:0005856,cellular_component,cytoskeleton;GO:0031032,biological_process,actomyosin structure organization;GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane;GO:0003779,molecular_function,actin binding;GO:0016020,cellular_component,membrane;GO:0030863,cellular_component,cortical cytoskeleton;GO:0051219,molecular_function,phosphoprotein binding;GO:0008360,biological_process,regulation of cell shape;GO:0032092,biological_process,positive regulation of protein binding;GO:0005545,molecular_function,1-phosphatidylinositol binding;GO:0005200,molecular_function,structural constituent of cytoskeleton","K06107,ko04530,Tight junction"]
["CCDC53",3.846249943,1.642739987,1.220707883,2.974152882,0.017533495,0.031068767,"ENSG00000120860","G1R3G5,WASH complex subunit 3","XP_003269974.1,-","PF10152,Subunit CCDC53 of WASH complex","IPR019309,WASH complex subunit 3","KOG4496,Predicted coiled-coil protein;ENOG4111KKV,-","GO:0071203,cellular_component,WASH complex","K18463,ko04144,Endocytosis;K18463,ko04212,Longevity regulating pathway - worm"]
["RP1-179P9.3",10.72400656,4.580241705,1.220707883,2.974152882,0.017533495,0.031068767,"ENSG00000282218","A0A0J9YVX5,Uncharacterized protein","-","PF00595,PDZ domain (Also known as DHR or GLGF);PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR000719,Protein kinase domain","-","GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["CHFR",1.206225996,0.516547733,1.220326207,3.959297556,0.001226002,0.002907213,"ENSG00000072609","K7B2A2,Checkpoint with forkhead and ring finger domains","XP_016780212.1,E3 ubiquitin-protein ligase CHFR isoform X19","PF13923,Zinc finger, C3HC4 type (RING finger);PF00498,HA domain","IPR001841,Zinc finger, RING-type;IPR008984,SMAD/FHA domain superfamily;IPR017907,Zinc finger, RING-type, conserved site;IPR000253,Forkhead-associated (FHA) domain;IPR013083,Zinc finger, RING/FYVE/PHD-type","COG5243,HRD ubiquitin ligase complex, ER membrane component;KOG0802,E3 ubiquitin ligase","-","-"]
["PDXDC2P",1.932737641,0.827665171,1.218732621,3.406606624,0.005648832,0.011453527,"ENSG00000255185","Q86XE2,PDXDC1 protein","NP_001272378.1,pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 6;XP_016855156.1,-;XP_016885698.1,-","PF00282,Pyridoxal-dependent decarboxylase conserved domain","IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR002129,Pyridoxal phosphate-dependent decarboxylase;IPR015424,Pyridoxal phosphate-dependent transferase","KOG0630,Predicted pyridoxal-dependent decarboxylase;ENOG410XYFU,-","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0005794,cellular_component,Golgi apparatus;GO:0016831,molecular_function,carboxy-lyase activity;GO:0003824,molecular_function,catalytic activity;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0019752,biological_process,carboxylic acid metabolic process;GO:0016829,molecular_function,lyase activity","-"]
["ZNF316",5.51662702,2.368243795,1.21791318,4.569304434,1.92299E-4,0.000548991,"ENSG00000205903","A0A096NQ82,Zinc finger protein 316","XP_009200849.1,zinc finger protein 316 isoform X2;XP_009200850.1,-;XP_017812078.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["NUMA1",24.97199767,10.73988827,1.217159185,8.091384198,{"v":2.89e-08,"d":"2.89E-08"},{"v":1.92E-7,"d":"1.92E-07"},"ENSG00000137497","Q4LE64,NUMA1 variant protein","NP_001273490.1,nuclear mitotic apparatus protein 1 isoform 2;NP_006176.2,nuclear mitotic apparatus protein 1 isoform 1;XP_006718627.1,-","-","IPR026650,Nuclear mitotic apparatus protein 1","ENOG410IFJ8,-;ENOG41125FF,-","GO:0000139,cellular_component,Golgi membrane","-"]
["PLS3",44.6070534,19.18497849,1.216934936,7.040395901,{"v":1.62e-07,"d":"1.62E-07"},{"v":9.06e-07,"d":"9.06E-07"},"ENSG00000102024","G1RXB0,Plastin 3","-","PF13499,-hand domain pair;PF00307,Calponin homology (CH) domain","IPR018247,EF-Hand 1, calcium-binding site;IPR036872,CH domain superfamily;IPR001715,Calponin homology domain;IPR002048,EF-hand domain;IPR001589,Actinin-type actin-binding domain, conserved site;IPR011992,EF-hand domain pair","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);KOG0046,Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily","GO:0005829,cellular_component,cytosol;GO:0060348,biological_process,bone development;GO:0005886,cellular_component,plasma membrane;GO:0003779,molecular_function,actin binding;GO:0005509,molecular_function,calcium ion binding","-"]
["RFWD3",8.484654843,3.649152057,1.216096353,5.324865071,{"v":1.43E-5,"d":"1.43E-05"},{"v":5.26e-05,"d":"5.26E-05"},"ENSG00000168411","K7APE2,Ring finger and WD repeat domain 3","XP_016785652.1,-;XP_001137409.2,-;XP_009429520.2,-","PF13639,Ring finger domain","IPR037381,E3 ubiquitin-protein ligase RFWD3;IPR036322,WD40-repeat-containing domain superfamily;IPR001841,Zinc finger, RING-type;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001680,WD40 repeat","ENOG410XPPE,-;KOG1645,RING-finger-containing E3 ubiquitin ligase","GO:0097371,molecular_function,MDM2/MDM4 family protein binding;GO:0035861,cellular_component,site of double-strand break;GO:0016567,biological_process,protein ubiquitination;GO:0031571,biological_process,mitotic G1 DNA damage checkpoint;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0090734,cellular_component,site of DNA damage;GO:0031297,biological_process,replication fork processing;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0010212,biological_process,response to ionizing radiation;GO:0002039,molecular_function,p53 binding;GO:0000724,biological_process,double-strand break repair via homologous recombination;GO:2000001,biological_process,regulation of DNA damage checkpoint;GO:0005634,cellular_component,nucleus;GO:0036297,biological_process,interstrand cross-link repair;GO:0005654,cellular_component,nucleoplasm","-"]
["STIP1",57.2107114,24.6257689,1.215869943,7.580853909,{"v":6.06E-8,"d":"6.06E-08"},{"v":3.74e-07,"d":"3.74E-07"},"ENSG00000168439","H2R1G1,Uncharacterized protein","-","PF13414,TPR repeat;PF13181,Tetratricopeptide repeat;PF07719,Tetratricopeptide repeat;PF13424,Tetratricopeptide repeat","-","-","-","-"]
["SMPD1",2.504125168,1.072353093,1.213978186,2.492070708,0.043957484,0.070130642,"ENSG00000166311","Q59EN6,Sphingomyelin phosphodiesterase 1, acid lysosomal isoform 1 variant","NP_000534.3,sphingomyelin phosphodiesterase isoform 1 precursor;NP_001305017.1,sphingomyelin phosphodiesterase isoform 4;NP_001007594.2,sphingomyelin phosphodiesterase isoform 2 precursor","PF00149,Calcineurin-like phosphoesterase","IPR008139,Saposin B type domain;IPR029052,Metallo-dependent phosphatase-like;IPR004843,Calcineurin-like phosphoesterase domain, ApaH type;IPR011001,Saposin-like;IPR011160,Sphingomyelin phosphodiesterase","KOG3770,Acid sphingomyelinase and PHM5 phosphate metabolism protein;ENOG410YYPB,-","GO:0016787,molecular_function,hydrolase activity;GO:0004767,molecular_function,sphingomyelin phosphodiesterase activity;GO:0046872,molecular_function,metal ion binding;GO:0006685,biological_process,sphingomyelin catabolic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K12350,ko00600,Sphingolipid metabolism;K12350,ko04142,Lysosome;K12350,ko04071,Sphingolipid signaling pathway"]
["RP1-71H24.1",11.97625081,5.128645227,1.213978186,2.492070708,0.043957484,0.070130642,"ENSG00000257452","S4R3V1,Calcium uptake protein 1, mitochondrial","-","PF13202,hand","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR011992,EF-hand domain pair","KOG2643,Ca2+ binding protein, contains EF-hand motifs;ENOG410ZSC1,-","GO:0005509,molecular_function,calcium ion binding","-"]
["FBXO41",0.859611061,0.368115217,1.213978186,2.492070708,0.043957484,0.070130642,"ENSG00000163013","A0A0D9RSD7,F-box protein 41","XP_007968410.1,F-box only protein 41 isoform X1","PF12937,-box-like","IPR036047,F-box-like domain superfamily;IPR001810,F-box domain","-","-","-"]
["DIRC2",2.971553542,1.275664135,1.213823782,3.067500193,0.011974922,0.022351244,"ENSG00000138463","G3QDW1,Disrupted in renal carcinoma 2","XP_004036230.1,disrupted in renal carcinoma protein 2","-","IPR036259,MFS transporter superfamily;IPR020846,Major facilitator superfamily domain","-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ST8SIA4",1.858489718,0.798768983,1.213750191,3.476130113,0.004044307,0.008504512,"ENSG00000113532","F7IRK5,CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase isoform a","XP_002744789.1,-","PF00777,lycosyltransferase family 29 (sialyltransferase)","IPR012163,Sialyltransferase;IPR038578,GT29-like superfamiliy;IPR001675,Glycosyl transferase family 29","KOG2692,Sialyltransferase;ENOG410XT8P,-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0097503,biological_process,sialylation;GO:0001574,biological_process,ganglioside biosynthetic process;GO:0006486,biological_process,protein glycosylation;GO:0003828,molecular_function,alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0005794,cellular_component,Golgi apparatus;GO:0009311,biological_process,oligosaccharide metabolic process;GO:0016020,cellular_component,membrane;GO:0008373,molecular_function,sialyltransferase activity;GO:0006491,biological_process,N-glycan processing;GO:0016021,cellular_component,integral component of membrane","-"]
["POLR1C",5.052343517,2.171470337,1.213750191,3.476130113,0.004044307,0.008504512,"ENSG00000171453","G3R5P7,RNA polymerase I subunit C","XP_004044127.1,-","PF01193,RNA polymerase Rpb3/Rpb11 dimerisation domain;PF01000,RNA polymerase Rpb3/RpoA insert domain","IPR033901,DNA-directed RNA polymerases I and III subunit AC40;IPR001514,DNA-directed RNA polymerase, 30-40kDa subunit, conserved site;IPR011262,DNA-directed RNA polymerase, insert domain;IPR036603,RNA polymerase, RBP11-like subunit;IPR036643,DNA-directed RNA polymerase, insert domain superfamily;IPR011263,DNA-directed RNA polymerase, RpoA/D/Rpb3-type","-","GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0006351,biological_process,transcription, DNA-templated","-"]
["PRKCE",1.845420992,0.793694255,1.213707128,3.793447973,0.002000856,0.004527526,"ENSG00000171132","H2P6C3,Protein kinase C epsilon type","XP_002812114.1,-","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF00433,Protein kinase C terminal domain;PF00069,Protein kinase domain;PF00168,C2 domain","IPR027274,Protein kinase C, epsilon;IPR008271,Serine/threonine-protein kinase, active site;IPR014376,Protein kinase C, delta/epsilon/eta/theta types;IPR020454,Diacylglycerol/phorbol-ester binding;IPR017892,Protein kinase, C-terminal;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR000008,C2 domain;IPR034669,Novel protein kinase C epsilon, catalytic domain;IPR035892,C2 domain superfamily;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR017441,Protein kinase, ATP binding site;IPR000719,Protein kinase domain","KOG0694,Serine/threonine protein kinase;ENOG410XNPH,-","GO:0031397,biological_process,negative regulation of protein ubiquitination;GO:0051209,biological_process,release of sequestered calcium ion into cytosol;GO:0035669,biological_process,TRAM-dependent toll-like receptor 4 signaling pathway;GO:0032230,biological_process,positive regulation of synaptic transmission, GABAergic;GO:0050730,biological_process,regulation of peptidyl-tyrosine phosphorylation;GO:0035276,molecular_function,ethanol binding;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005856,cellular_component,cytoskeleton;GO:0003785,molecular_function,actin monomer binding;GO:0005886,cellular_component,plasma membrane;GO:0004672,molecular_function,protein kinase activity;GO:0051301,biological_process,cell division;GO:0005634,cellular_component,nucleus;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0005524,molecular_function,ATP binding;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0007155,biological_process,cell adhesion;GO:0031663,biological_process,lipopolysaccharide-mediated signaling pathway;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0090303,biological_process,positive regulation of wound healing;GO:0030546,molecular_function,receptor activator activity;GO:0016310,biological_process,phosphorylation;GO:0002281,biological_process,macrophage activation involved in immune response;GO:0071380,biological_process,cellular response to prostaglandin E stimulus;GO:0071889,molecular_function,14-3-3 protein binding;GO:0005739,cellular_component,mitochondrion;GO:0010634,biological_process,positive regulation of epithelial cell migration;GO:0032467,biological_process,positive regulation of cytokinesis;GO:0070257,biological_process,positive regulation of mucus secretion;GO:0010811,biological_process,positive regulation of cell-substrate adhesion;GO:0032024,biological_process,positive regulation of insulin secretion;GO:0043085,biological_process,positive regulation of catalytic activity;GO:0061178,biological_process,regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0019216,biological_process,regulation of lipid metabolic process;GO:2000273,biological_process,positive regulation of signaling receptor activity;GO:0016740,molecular_function,transferase activity;GO:0007049,biological_process,cell cycle;GO:0010763,biological_process,positive regulation of fibroblast migration;GO:0016020,cellular_component,membrane;GO:0035641,biological_process,locomotory exploration behavior;GO:0071456,biological_process,cellular response to hypoxia;GO:0000166,molecular_function,nucleotide binding;GO:0051279,biological_process,regulation of release of sequestered calcium ion into cytosol;GO:0071361,biological_process,cellular response to ethanol;GO:0019899,molecular_function,enzyme binding;GO:0030838,biological_process,positive regulation of actin filament polymerization;GO:0004699,molecular_function,calcium-independent protein kinase C activity;GO:0043278,biological_process,response to morphine;GO:0004697,molecular_function,protein kinase C activity;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0046872,molecular_function,metal ion binding;GO:0071944,cellular_component,cell periphery;GO:0005829,cellular_component,cytosol;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:2001031,biological_process,positive regulation of cellular glucuronidation;GO:0050996,biological_process,positive regulation of lipid catabolic process;GO:0008047,molecular_function,enzyme activator activity;GO:0005794,cellular_component,Golgi apparatus;GO:0043410,biological_process,positive regulation of MAPK cascade","K18050,ko04666,Fc gamma R-mediated phagocytosis;K18050,ko04530,Tight junction;K18050,ko04270,Vascular smooth muscle contraction;K18050,ko04022,cGMP-PKG signaling pathway;K18050,ko05206,MicroRNAs in cancer;K18050,ko04931,Insulin resistance;K18050,ko04750,Inflammatory mediator regulation of TRP channels;K18050,ko04933,AGE-RAGE signaling pathway in diabetic complications;K18050,ko04071,Sphingolipid signaling pathway;K18050,ko04930,Type II diabetes mellitus;K18050,ko04925,Aldosterone synthesis and secretion"]
["TIA1",3.917535316,1.686174835,1.213658879,4.272675689,0.000426635,1.118183E-3,"ENSG00000116001","H2R1C4,TIA1 cytotoxic granule-associated RNA binding protein","XP_009440903.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034827,TIA-1, RNA recognition motif 1;IPR034830,TIA-1, RNA recognition motif 2;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034832,TIA-1, RNA recognition motif 3;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR003954,RNA recognition motif domain, eukaryote","KOG0148,Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily);ENOG410XQ8U,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["GPC4",7.516379599,3.236997744,1.213623351,4.781767565,{"v":8.91e-05,"d":"8.91E-05"},0.000271434,"ENSG00000076716","H2QZ47,Glypican 4","XP_529161.3,-","PF01153,lypican","IPR001863,Glypican;IPR031180,Glypican-4;IPR019803,Glypican, conserved site","ENOG410XST2,-;KOG3821,Heparin sulfate cell surface proteoglycan","GO:0043395,molecular_function,heparan sulfate proteoglycan binding;GO:0005578,,;GO:0009897,cellular_component,external side of plasma membrane;GO:0031225,cellular_component,anchored component of membrane;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0046658,cellular_component,anchored component of plasma membrane;GO:0009966,biological_process,regulation of signal transduction;GO:0005615,cellular_component,extracellular space","K08110,ko04310,Wnt signaling pathway"]
["RDX",73.05357625,31.5137476,1.212837663,8.432775278,{"v":2.3e-08,"d":"2.30E-08"},{"v":1.56e-07,"d":"1.56E-07"},"ENSG00000137710","G3S0P8,Radixin","XP_004052139.1,-","PF09379,RM N-terminal domain;PF09380,RM C-terminal PH-like domain;PF00373,RM central domain;PF00769,zrin/radixin/moesin family","IPR019747,FERM conserved site;IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR019748,FERM central domain;IPR011259,Ezrin/radixin/moesin, C-terminal;IPR011993,PH-like domain superfamily;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR000798,Ezrin/radixin/moesin-like;IPR011174,Ezrin/radixin/moesin;IPR029071,Ubiquitin-like domain superfamily;IPR008954,Moesin tail domain superfamily","-","GO:0034111,biological_process,negative regulation of homotypic cell-cell adhesion;GO:0045792,biological_process,negative regulation of cell size;GO:0005856,cellular_component,cytoskeleton;GO:0005886,cellular_component,plasma membrane;GO:1903392,biological_process,negative regulation of adherens junction organization;GO:0005925,cellular_component,focal adhesion;GO:0008361,biological_process,regulation of cell size;GO:1902115,biological_process,regulation of organelle assembly;GO:1902966,biological_process,positive regulation of protein localization to early endosome;GO:0043087,biological_process,regulation of GTPase activity;GO:2000643,biological_process,positive regulation of early endosome to late endosome transport;GO:0061028,biological_process,establishment of endothelial barrier;GO:1903364,biological_process,positive regulation of cellular protein catabolic process;GO:0051117,molecular_function,ATPase binding;GO:0030335,biological_process,positive regulation of cell migration;GO:0010628,biological_process,positive regulation of gene expression;GO:0032231,biological_process,regulation of actin filament bundle assembly;GO:0016324,cellular_component,apical plasma membrane;GO:0003779,molecular_function,actin binding;GO:0008360,biological_process,regulation of cell shape;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0072659,biological_process,protein localization to plasma membrane;GO:1900027,biological_process,regulation of ruffle assembly;GO:0071944,cellular_component,cell periphery;GO:0045296,molecular_function,cadherin binding;GO:0034260,biological_process,negative regulation of GTPase activity","K05762,ko04810,Regulation of actin cytoskeleton;K05762,ko05206,MicroRNAs in cancer;K05762,ko05205,Proteoglycans in cancer"]
["TOR1AIP2",9.045022487,3.905714937,1.211154847,6.94391457,{"v":2.1E-7,"d":"2.10E-07"},{"v":1.15E-6,"d":"1.15E-06"},"ENSG00000169905","A0A024R957,Torsin A interacting protein 2, isoform CRA_b","XP_016855964.1,-;NP_001186189.1,-;XP_005244996.1,-;NP_659471.1,torsin-1A-interacting protein 2 isoform b;XP_016855963.1,-","PF05609,Lamina-associated polypeptide 1C (LAP1C)","IPR038599,LAP1C-like, C-terminal domain superfamily;IPR008662,Lamina-associated polypeptide 1C","ENOG410IJUB,-;ENOG4111IZJ,-","GO:0005783,cellular_component,endoplasmic reticulum;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-463O12.5",1.425117151,0.61452259,1.211084946,4.311076066,0.000335594,9.02074E-4,"ENSG00000280138","G7PXF9,Uncharacterized protein","-","-","-","-","-","-"]
["PHF10",4.805843201,2.072320307,1.211084946,4.311076066,0.000335594,9.02074E-4,"ENSG00000130024","A0A096NY21,PHD finger protein 10","-","PF00628,PHD-finger","IPR038045,PHD finger protein 10","-","GO:0071564,cellular_component,npBAF complex;GO:0046872,molecular_function,metal ion binding","-"]
["CXADR",8.06696393,3.481607992,1.21106002,5.301621251,{"v":1.65e-05,"d":"1.65E-05"},{"v":5.99e-05,"d":"5.99E-05"},"ENSG00000154639","H2QKV2,CXADR, Ig-like cell adhesion molecule","XP_009443294.1,-","PF07686,Immunoglobulin V-set domain;PF00047,Immunoglobulin domain","IPR007110,Immunoglobulin-like domain;IPR013151,Immunoglobulin;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain","ENOG410IGDG,-;ENOG4110WP1,-","GO:0007157,biological_process,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0032991,cellular_component,protein-containing complex;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0030593,biological_process,neutrophil chemotaxis;GO:0005886,cellular_component,plasma membrane;GO:0050839,molecular_function,cell adhesion molecule binding;GO:0005923,cellular_component,bicellular tight junction;GO:0005737,cellular_component,cytoplasm;GO:0005913,cellular_component,cell-cell adherens junction;GO:0005912,cellular_component,adherens junction;GO:0016323,cellular_component,basolateral plasma membrane;GO:0008013,molecular_function,beta-catenin binding;GO:0070633,biological_process,transepithelial transport;GO:0016327,cellular_component,apicolateral plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0030054,cellular_component,cell junction;GO:0016020,cellular_component,membrane;GO:0005654,cellular_component,nucleoplasm;GO:0045121,cellular_component,membrane raft;GO:0005911,cellular_component,cell-cell junction;GO:0030165,molecular_function,PDZ domain binding;GO:0010669,biological_process,epithelial structure maintenance;GO:0005178,molecular_function,integrin binding","-"]
["CENPN",6.389062205,2.755017756,1.210676366,4.097657502,0.000674933,0.00169238,"ENSG00000166451","G1RHM3,Centromere protein N","XP_003272513.1,centromere protein N isoform X2","PF05238,Kinetochore protein CHL4 like","IPR007902,Centromere protein Chl4/mis15/CENP-N","ENOG4111H2Z,-;ENOG410IKJC,-","GO:0007059,biological_process,chromosome segregation;GO:0051382,biological_process,kinetochore assembly;GO:0005634,cellular_component,nucleus","-"]
["IER2",17.77859161,7.679611994,1.209841296,5.32052974,{"v":1.43E-5,"d":"1.43E-05"},{"v":5.26e-05,"d":"5.26E-05"},"ENSG00000160888","A0A024R7H1,Immediate early response 2, isoform CRA_a","NP_004898.2,immediate early response gene 2 protein","PF05760,Immediate early response protein (IER)","IPR008653,Immediate early response","ENOG410IXGG,-;ENOG410Z3CN,-","GO:0005737,cellular_component,cytoplasm;GO:0005654,cellular_component,nucleoplasm","-"]
["POMT1",2.504936426,1.080149811,1.209248629,3.542430667,0.003718087,0.007882383,"ENSG00000130714","G3R9Y3,Protein O-mannosyltransferase 1","XP_018889073.1,protein O-mannosyl-transferase 1 isoform X5","PF02815,MIR domain;PF16192,C-terminal four TMM region of protein-O-mannosyltransferase;PF02366,olichyl-phosphate-mannose-protein mannosyltransferase","IPR027005,Glycosyltransferase 39-like;IPR032421,Protein O-mannosyl-transferase, C-terminal four TM domain;IPR016093,MIR motif;IPR036300,Mir domain superfamily;IPR003342,Glycosyl transferase family 39/83","-","GO:0097502,biological_process,mannosylation;GO:0006493,biological_process,protein O-linked glycosylation;GO:0030198,biological_process,extracellular matrix organization;GO:0016020,cellular_component,membrane;GO:0001669,cellular_component,acrosomal vesicle;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0016529,cellular_component,sarcoplasmic reticulum;GO:0016021,cellular_component,integral component of membrane;GO:0000030,molecular_function,mannosyltransferase activity","-"]
["PSMF1",22.463658,9.713587779,1.20896908,6.427739353,{"v":7.28e-07,"d":"7.28E-07"},{"v":3.54E-6,"d":"3.54E-06"},"ENSG00000125818","A0A140VJT2,Testicular tissue protein Li 158","NP_848693.2,-;NP_006805.2,proteasome inhibitor PI31 subunit isoform 1","PF11566,PI31 proteasome regulator N-terminal;PF08577,PI31 proteasome regulator","IPR013886,PI31 proteasome regulator, C-terminal;IPR021625,PI31 proteasome regulator,  N-terminal","-","GO:0005829,cellular_component,cytosol","K06700,ko03050,Proteasome"]
["ZNF337",2.981450948,1.28562691,1.20782445,3.155112705,0.008262948,0.016075389,"ENSG00000130684","A8K5C0,cDNA FLJ78383, highly similar to Homo sapiens zinc finger protein 337","NP_056470.1,zinc finger protein 337","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["UBQLN2",2.694583209,1.16192711,1.20782445,3.155112705,0.008262948,0.016075389,"ENSG00000188021","H2QYP6,Ubiquilin 2","XP_001148687.1,ubiquilin-2","PF00627,UBA/TS-N domain;PF00240,Ubiquitin family","IPR006636,Heat shock chaperonin-binding;IPR015496,Ubiquilin;IPR009060,UBA-like superfamily;IPR015940,Ubiquitin-associated domain;IPR000626,Ubiquitin domain;IPR016024,Armadillo-type fold;IPR029071,Ubiquitin-like domain superfamily;IPR028430,Ubiquilin-2","COG5272,Ubiquitin;KOG0010,Ubiquitin-like protein","-","K04523,ko04141,Protein processing in endoplasmic reticulum"]
["TFAP4",6.640553192,2.873875392,1.207061425,5.258515451,{"v":2.21e-05,"d":"2.21E-05"},{"v":7.8e-05,"d":"7.80E-05"},"ENSG00000090447","Q6FHM5,TFAP4 protein","-","PF00010,Helix-loop-helix DNA-binding domain","IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","ENOG4111JPE,-;KOG0561,bHLH transcription factor","GO:0046983,molecular_function,protein dimerization activity","-"]
["ZWINT",39.14397685,16.94810923,1.206967773,6.078295177,{"v":1.93e-06,"d":"1.93E-06"},{"v":8.6e-06,"d":"8.60E-06"},"ENSG00000122952","A0A024QZN5,ZW10 interactor, isoform CRA_b","-","PF15556,ZW10 interactor","IPR029092,ZW10 interactor","ENOG4111831,-;ENOG410IJ58,-","GO:0007093,biological_process,mitotic cell cycle checkpoint;GO:0000776,cellular_component,kinetochore","-"]
["MFN1",15.74563663,6.820592108,1.206290845,6.089357099,{"v":1.93e-06,"d":"1.93E-06"},{"v":8.6e-06,"d":"8.60E-06"},"ENSG00000171109","A0A0C4DFN1,Mitofusin-1","-","PF04799,fzo-like conserved region;PF00350,ynamin family","IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR027094,Mitofusin family;IPR027088,Mitofusin-1;IPR030381,Dynamin-type guanine nucleotide-binding (G) domain;IPR022812,Dynamin superfamily;IPR006884,Fzo/mitofusin HR2 domain","-","GO:0005741,cellular_component,mitochondrial outer membrane;GO:0005525,molecular_function,GTP binding;GO:0008053,biological_process,mitochondrial fusion;GO:0005739,cellular_component,mitochondrion;GO:0003924,molecular_function,GTPase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["EXOC4",3.436725111,1.488435257,1.205243453,4.593394524,1.85176E-4,0.000530067,"ENSG00000131558","Q6NX51,Exocyst complex component 4","NP_001032203.1,exocyst complex component 4 isoform b","PF04048,Sec8 exocyst complex component specific domain","IPR007191,Sec8 exocyst complex component specific domain","KOG3691,Exocyst complex subunit Sec8;ENOG410Z8N0,-","GO:0015031,biological_process,protein transport;GO:0000145,cellular_component,exocyst;GO:0006904,biological_process,vesicle docking involved in exocytosis","-"]
["ESD",2.234261879,0.963432652,1.204986708,2.621414116,0.028516058,0.048048259,"ENSG00000139684","A0A140VJJ2,S-formylglutathione hydrolase","XP_005266335.1,-;XP_011533256.1,-;NP_001975.1,S-formylglutathione hydrolase","PF00326,Prolyl oligopeptidase family;PF00756,Putative esterase;PF05448,Acetyl xylan esterase (AXE1)","IPR014186,S-formylglutathione hydrolase;IPR029058,Alpha/Beta hydrolase fold;IPR000801,Putative esterase","-","GO:0005737,cellular_component,cytoplasm;GO:0046294,biological_process,formaldehyde catabolic process;GO:0052689,molecular_function,carboxylic ester hydrolase activity;GO:0016787,molecular_function,hydrolase activity;GO:0018738,molecular_function,S-formylglutathione hydrolase activity","K01070,ko00680,Methane metabolism;K01070,ko01200,Carbon metabolism"]
["FAM21C",6.49662972,2.815767943,1.204413352,4.775411981,1.04659E-4,0.000315407,"ENSG00000172661","A0A0A0MR88,WASH complex subunit 2C","-","PF15255,WASH complex subunit CAP-Z interacting, central region","IPR027308,WASH complex subunit 2;IPR029341,FAM21/CAPZIP domain","ENOG410IEJH,-;ENOG4110AMY,-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005829,cellular_component,cytosol;GO:0071203,cellular_component,WASH complex;GO:0005730,cellular_component,nucleolus","-"]
["RAC1",154.6464915,67.13207385,1.203765578,8.435498952,{"v":2.8e-08,"d":"2.80E-08"},{"v":1.87e-07,"d":"1.87E-07"},"ENSG00000136238","U3BVZ6,Ras-related C3 botulinum toxin substrate 1 isoform Rac1b","-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR003578,Small GTPase superfamily, Rho type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0003924,molecular_function,GTPase activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular","-"]
["NISCH",2.229185951,0.965714771,1.203675369,3.947904743,0.00151521,0.003513078,"ENSG00000010322","G3RIP0,Nischarin","XP_004034333.1,nischarin isoform X1","PF00787,PX domain","IPR001683,Phox homologous domain;IPR036871,PX domain superfamily;IPR001611,Leucine-rich repeat;IPR037904,Nischarin, PX domain;IPR032675,Leucine-rich repeat domain superfamily","-","GO:0030036,biological_process,actin cytoskeleton organization;GO:0016601,biological_process,Rac protein signal transduction;GO:0005178,molecular_function,integrin binding;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane;GO:0042802,molecular_function,identical protein binding;GO:0030336,biological_process,negative regulation of cell migration","-"]
["UBE2E3",31.46965935,13.66642018,1.202635165,6.086819563,{"v":1.93e-06,"d":"1.93E-06"},{"v":8.6e-06,"d":"8.60E-06"},"ENSG00000170035","A0A091VB80,Ubiquitin-conjugating enzyme E2 E3","XP_009935557.1,ubiquitin-conjugating enzyme E2 E3 isoform X1","PF00179,Ubiquitin-conjugating enzyme","IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR023313,Ubiquitin-conjugating enzyme, active site;IPR000608,Ubiquitin-conjugating enzyme E2","-","GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["LRP8",1.180587581,0.511075758,1.202549571,3.237656938,0.01130034,0.021192911,"ENSG00000157193","H2PZ23,Uncharacterized protein","XP_009456320.1,low-density lipoprotein receptor-related protein 8 isoform X3","PF14670,Coagulation Factor Xa inhibitory site;PF00057,Low-density lipoprotein receptor domain class A;PF00058,Low-density lipoprotein receptor repeat class B","IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR018097,EGF-like calcium-binding, conserved site;IPR000033,LDLR class B repeat;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR011042,Six-bladed beta-propeller, TolB-like;IPR001881,EGF-like calcium-binding domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR036055,LDL receptor-like superfamily","ENOG410IPT5,-;ENOG410YQ6J,-","GO:0006898,biological_process,receptor-mediated endocytosis;GO:0005901,cellular_component,caveola;GO:0005509,molecular_function,calcium ion binding;GO:0016020,cellular_component,membrane;GO:0030229,molecular_function,very-low-density lipoprotein particle receptor activity;GO:0043235,cellular_component,receptor complex;GO:0006897,biological_process,endocytosis;GO:0016021,cellular_component,integral component of membrane","-"]
["AP5B1",2.517245356,1.089714222,1.202549571,3.237656938,0.01130034,0.021192911,"ENSG00000254470","A0A0D9R6L9,Adaptor related protein complex 5 beta 1 subunit","XP_007981114.1,AP-5 complex subunit beta-1","-","-","-","GO:0016197,biological_process,endosomal transport;GO:0030119,cellular_component,AP-type membrane coat adaptor complex","-"]
["GPSM1",2.446559073,1.059114166,1.202549571,3.237656938,0.01130034,0.021192911,"ENSG00000160360","A0A0A0MSK4,G-protein-signaling modulator 1","NP_001139110.2,G-protein-signaling modulator 1 isoform a","PF02188,oLoco motif;PF13424,Tetratricopeptide repeat","IPR003109,GoLoco motif;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","KOG1130,Predicted G-alpha GTPase interaction protein, contains GoLoco domain;ENOG410XP6N,-","GO:0030695,molecular_function,GTPase regulator activity;GO:0005794,cellular_component,Golgi apparatus;GO:0050790,biological_process,regulation of catalytic activity;GO:0005654,cellular_component,nucleoplasm","K15839,ko05030,Cocaine addiction"]
["POLE",3.088168546,1.341508475,1.201636169,5.234163183,{"v":2.56e-05,"d":"2.56E-05"},{"v":8.89e-05,"d":"8.89E-05"},"ENSG00000177084","Q9Y5S4,DNA polymerase epsilon catalytic subunit protein isoform b","-","PF00136,NA polymerase family B;PF08490,omain of unknown function (DUF1744);PF03104,NA polymerase family B, exonuclease domain","IPR029703,DNA polymerase epsilon catalytic subunit;IPR006172,DNA-directed DNA polymerase, family B;IPR036397,Ribonuclease H superfamily;IPR013697,DNA polymerase epsilon, catalytic subunit A, C-terminal;IPR006134,DNA-directed DNA polymerase, family B, multifunctional domain;IPR006133,DNA-directed DNA polymerase, family B, exonuclease domain;IPR012337,Ribonuclease H-like superfamily","KOG1798,DNA polymerase epsilon, catalytic subunit A;COG0417,DNA polymerase elongation subunit (family B)","GO:0003887,molecular_function,DNA-directed DNA polymerase activity;GO:0003677,molecular_function,DNA binding;GO:0071897,biological_process,DNA biosynthetic process;GO:0003676,molecular_function,nucleic acid binding;GO:0006260,biological_process,DNA replication;GO:0006281,biological_process,DNA repair;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0008622,cellular_component,epsilon DNA polymerase complex","-"]
["PLOD1",10.48931093,4.557724612,1.201377302,5.353381498,{"v":1.78e-05,"d":"1.78E-05"},{"v":6.39e-05,"d":"6.39E-05"},"ENSG00000083444","A0A024R4H0,Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1, isoform CRA_a","NP_000293.2,procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform 2 precursor","PF03171,2OG-Fe(II) oxygenase superfamily","IPR001006,Procollagen-lysine 5-dioxygenase;IPR006620,Prolyl 4-hydroxylase, alpha subunit;IPR029044,Nucleotide-diphospho-sugar transferases;IPR005123,Oxoglutarate/iron-dependent dioxygenase","KOG1971,Lysyl hydroxylase;ENOG410Y4QU,-","GO:0008475,molecular_function,procollagen-lysine 5-dioxygenase activity;GO:0051213,molecular_function,dioxygenase activity;GO:0031418,molecular_function,L-ascorbic acid binding;GO:0016705,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0046872,molecular_function,metal ion binding;GO:0016491,molecular_function,oxidoreductase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005506,molecular_function,iron ion binding;GO:0055114,biological_process,oxidation-reduction process;GO:1902494,cellular_component,catalytic complex","K00473,ko00310,Lysine degradation"]
["NKTR",3.25625228,1.41592293,1.200328852,5.371627724,{"v":1.75e-05,"d":"1.75E-05"},{"v":6.33e-05,"d":"6.33E-05"},"ENSG00000114857","A0A024R2N6,Natural killer-tumor recognition sequence, isoform CRA_a","NP_005376.2,NK-tumor recognition protein isoform a","PF00160,Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD","IPR024936,Cyclophilin-type peptidyl-prolyl cis-trans isomerase;IPR029000,Cyclophilin-like domain superfamily;IPR020892,Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site;IPR002130,Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain","KOG0546,HSP90 co-chaperone CPR7/Cyclophilin;COG0652,Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family","GO:0003755,molecular_function,peptidyl-prolyl cis-trans isomerase activity;GO:0006457,biological_process,protein folding;GO:0000413,biological_process,protein peptidyl-prolyl isomerization;GO:0005886,cellular_component,plasma membrane;GO:0005739,cellular_component,mitochondrion;GO:0005829,cellular_component,cytosol;GO:0016853,molecular_function,isomerase activity;GO:0005654,cellular_component,nucleoplasm","-"]
["VPS36",8.586464106,3.73538662,1.19947031,5.147187089,{"v":3.68E-5,"d":"3.68E-05"},1.23249E-4,"ENSG00000136100","H2Q7L7,Vacuolar protein sorting 36 homolog","XP_509796.2,-","PF04157,AP30/Vps36 family;PF11605,Vacuolar protein sorting protein 36 Vps36","IPR037855,Vacuolar protein sorting protein 36;IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR011993,PH-like domain superfamily;IPR021648,Vacuolar protein sorting protein 36, GLUE domain","KOG2760,Vacuolar sorting protein VPS36;ENOG410XR74,-","GO:0031902,cellular_component,late endosome membrane;GO:0005770,cellular_component,late endosome;GO:0032266,molecular_function,phosphatidylinositol-3-phosphate binding;GO:0043328,biological_process,protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0005768,cellular_component,endosome;GO:0005764,cellular_component,lysosome;GO:0000814,cellular_component,ESCRT II complex;GO:0008022,molecular_function,protein C-terminus binding;GO:0005829,cellular_component,cytosol;GO:0043130,molecular_function,ubiquitin binding;GO:0032509,biological_process,endosome transport via multivesicular body sorting pathway","-"]
["ANAPC5",4.651161818,2.023928952,1.199307222,5.389645836,{"v":1.53e-05,"d":"1.53E-05"},{"v":5.58e-05,"d":"5.58E-05"},"ENSG00000089053","G1S249,Anaphase promoting complex subunit 5","XP_003280350.1,-","PF12862,Anaphase-promoting complex subunit 5","IPR026000,Anaphase-promoting complex subunit 5 domain;IPR037679,Anaphase-promoting complex subunit 5;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat","ENOG410YVZN,-;KOG4322,Anaphase-promoting complex (APC), subunit 5","GO:0005680,cellular_component,anaphase-promoting complex;GO:0005634,cellular_component,nucleus;GO:0070979,biological_process,protein K11-linked ubiquitination;GO:0019903,molecular_function,protein phosphatase binding","K03352,ko05166,HTLV-I infection;K03352,ko04120,Ubiquitin mediated proteolysis;K03352,ko04113,Meiosis - yeast;K03352,ko04110,Cell cycle;K03352,ko04114,Oocyte meiosis;K03352,ko04111,Cell cycle - yeast;K03352,ko04914,Progesterone-mediated oocyte maturation"]
["PPDPF",230.2972707,100.3356984,1.198407082,7.505803134,{"v":1e-07,"d":"1.00E-07"},{"v":5.87e-07,"d":"5.87E-07"},"ENSG00000125534","X6R7I6,Pancreatic progenitor cell differentiation and proliferation factor","-","PF15060,ifferentiation and proliferation regulator","IPR026754,Pancreatic progenitor cell differentiation and proliferation factor","-","GO:0030154,biological_process,cell differentiation;GO:0007275,biological_process,multicellular organism development","-"]
["MXD4",4.373734611,1.903400574,1.19820254,4.522143122,0.000283525,7.77171E-4,"ENSG00000123933","K7DEU0,MAX dimerization protein 4","-","PF00010,Helix-loop-helix DNA-binding domain","IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","ENOG4111V1C,-;KOG2483,Upstream transcription factor 2/L-myc-2 protein","GO:0046983,molecular_function,protein dimerization activity","-"]
["B4GALT3",3.296361914,1.431948218,1.197875364,3.315689452,0.007955833,0.015515418,"ENSG00000158850","G3QX18,Beta-1,4-galactosyltransferase 3","XP_018881186.1,-;XP_018881178.1,-","PF02709,N-terminal domain of galactosyltransferase;PF13733,N-terminal region of glycosyl transferase group 7","IPR027995,Galactosyltransferase, N-terminal;IPR027791,Galactosyltransferase, C-terminal;IPR029044,Nucleotide-diphospho-sugar transferases;IPR003859,Beta-1,4-galactosyltransferase","-","GO:0005975,biological_process,carbohydrate metabolic process;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0008378,molecular_function,galactosyltransferase activity;GO:0005794,cellular_component,Golgi apparatus;GO:0006682,biological_process,galactosylceramide biosynthetic process;GO:0005829,cellular_component,cytosol","K07968,ko00513,Various types of N-glycan biosynthesis;K07968,ko00601,Glycosphingolipid biosynthesis - lacto and neolacto series;K07968,ko00510,N-Glycan biosynthesis;K07968,ko00533,Glycosaminoglycan biosynthesis - keratan sulfate;K07968,ko00514,Other types of O-glycan biosynthesis"]
["COL4A6",1.381474666,0.6001162,1.197875364,3.315689452,0.007955833,0.015515418,"ENSG00000197565","G3SFQ2,Collagen type IV alpha 6 chain","-","PF01391,Collagen triple helix repeat (20 copies);PF01413,C-terminal tandem repeated domain in type 4 procollagen","IPR008160,Collagen triple helix repeat;IPR016187,C-type lectin fold;IPR036954,Collagen IV, non-collagenous domain superfamily;IPR001442,Collagen IV, non-collagenous","-","GO:0005604,cellular_component,basement membrane;GO:0005578,,;GO:0005201,molecular_function,extracellular matrix structural constituent;GO:0005576,cellular_component,extracellular region;GO:0005581,cellular_component,collagen trimer","-"]
["RP11-157P1.4",12.20426591,5.292654766,1.19757254,2.739969871,0.02513009,0.042818267,"ENSG00000226332","A0A287AW94,Uncharacterized protein","-","-","IPR006773,Proteasomal ubiquitin receptor Rpn13/ADRM1;IPR038633,Proteasomal ubiquitin receptor Rpn13/ADRM1 superfamily","-","GO:0005737,cellular_component,cytoplasm;GO:0005634,cellular_component,nucleus","-"]
["CDCA8",36.8356564,16.05803032,1.197101962,6.048106622,{"v":2.31e-06,"d":"2.31E-06"},{"v":1.01E-5,"d":"1.01E-05"},"ENSG00000134690","A8K7A2,cDNA FLJ78084, highly similar to Homo sapiens cell division cycle associated 8, mRNA","-","PF10444,Nbl1 / Borealin N terminal;PF10512,Cell division cycle-associated protein 8","IPR018867,Cell division protein borealin;IPR018851,Borealin, N-terminal","ENOG410IICJ,-;ENOG4111N8R,-","GO:0051301,biological_process,cell division","-"]
["FZR1",5.443329769,2.371917389,1.196403287,4.55449402,2.28703E-4,0.000638793,"ENSG00000105325","K7BP89,Fizzy/cell division cycle 20 related 1","XP_016792534.1,-","PF12894,Anaphase-promoting complex subunit 4 WD40 domain;PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR033010,The WD repeat Cdc20/Fizzy family;IPR017986,WD40-repeat-containing domain;IPR024977,Anaphase-promoting complex subunit 4, WD40 domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat","-","GO:0097027,molecular_function,ubiquitin-protein transferase activator activity;GO:1904668,biological_process,positive regulation of ubiquitin protein ligase activity;GO:0010997,molecular_function,anaphase-promoting complex binding;GO:0051301,biological_process,cell division","K03364,ko04914,Progesterone-mediated oocyte maturation;K03364,ko04110,Cell cycle;K03364,ko04120,Ubiquitin mediated proteolysis;K03364,ko04111,Cell cycle - yeast"]
["SNRNP40",22.45500472,9.793599492,1.196389731,5.987543651,{"v":2.8e-06,"d":"2.80E-06"},{"v":1.2E-5,"d":"1.20E-05"},"ENSG00000060688","H9G208,U5 small nuclear ribonucleoprotein 40 kDa protein","NP_001182579.1,-","-","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat","KOG0265,U5 snRNP-specific protein-like factor and related proteins;ENOG410XSEW,-","GO:0030529,,","K12857,ko03040,Spliceosome"]
["ARHGAP19",2.926377662,1.275161778,1.194883768,3.780621517,0.002000856,0.004527526,"ENSG00000213390","G3QTZ6,Uncharacterized protein","-","PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain","-","GO:0007165,biological_process,signal transduction","-"]
["RP11-613M10.8",8.63625645,3.76858796,1.194078079,4.376511989,0.000424834,0.001115674,"ENSG00000256966","H3BUX3,Uncharacterized protein","-","PF15178,Mitochondrial import receptor subunit TOM5 homolog","IPR029179,Mitochondrial import receptor subunit TOM5 homologue","ENOG41117YX,-;ENOG410J6QN,-","GO:0005742,cellular_component,mitochondrial outer membrane translocase complex","-"]
["DYRK4",1.918801854,0.836113129,1.193704736,3.389679778,7.223709E-3,0.014251704,"ENSG00000010219","A0A0A0MTH5,Dual-specificity tyrosine-phosphorylation-regulated kinase 4","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XPET,-;KOG0667,Dual-specificity tyrosine-phosphorylation regulated kinase","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["FARP2",0.939098611,0.409209881,1.193704736,3.389679778,7.223709E-3,0.014251704,"ENSG00000006607","K7B3S8,FERM, RhoGEF and pleckstrin domain protein 2","XP_016806414.1,FERM, RhoGEF and pleckstrin domain-containing protein 2 isoform X1","PF09380,RM C-terminal PH-like domain;PF00621,RhoGEF domain;PF09379,RM N-terminal domain;PF08736,RM adjacent (FA);PF00373,RM central domain;PF00169,PH domain","IPR019748,FERM central domain;IPR014847,FERM adjacent (FA);IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR019747,FERM conserved site;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR035899,Dbl homology (DH) domain superfamily;IPR000798,Ezrin/radixin/moesin-like;IPR029071,Ubiquitin-like domain superfamily;IPR000219,Dbl homology (DH) domain","KOG3531,Rho guanine nucleotide exchange factor CDEP;ENOG410XP7Q,-","GO:0007155,biological_process,cell adhesion;GO:0005856,cellular_component,cytoskeleton;GO:0071800,biological_process,podosome assembly;GO:0005737,cellular_component,cytoplasm;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0071526,biological_process,semaphorin-plexin signaling pathway;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0065009,biological_process,regulation of molecular function;GO:0033623,biological_process,regulation of integrin activation;GO:0016601,biological_process,Rac protein signal transduction;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0030676,molecular_function,Rac guanyl-nucleotide exchange factor activity;GO:0030316,biological_process,osteoclast differentiation;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0022405,biological_process,hair cycle process;GO:0016322,biological_process,neuron remodeling","K06082,ko04520,Adherens junction;K06082,ko04015,Rap1 signaling pathway"]
["CCDC152",6.782598146,2.96052661,1.193236005,4.130954071,0.000902423,0.00219343,"ENSG00000198865","H2R5J5,Coiled-coil domain containing 152","-","-","-","-","-","-"]
["TUBB4B",151.8575065,66.4329486,1.192548216,7.85361704,{"v":7.41e-08,"d":"7.41E-08"},{"v":4.48e-07,"d":"4.48E-07"},"ENSG00000188229","I3MV11,Tubulin beta chain","XP_005336936.1,-","PF03953,Tubulin C-terminal domain;PF00091,Tubulin/FtsZ family, GTPase domain","IPR017975,Tubulin, conserved site;IPR018316,Tubulin/FtsZ, 2-layer sandwich domain;IPR003008,Tubulin/FtsZ, GTPase domain;IPR008280,Tubulin/FtsZ, C-terminal;IPR036525,Tubulin/FtsZ, GTPase domain superfamily;IPR037103,Tubulin/FtsZ, C-terminal domain superfamily;IPR013838,Beta tubulin, autoregulation binding site;IPR000217,Tubulin;IPR023123,Tubulin, C-terminal;IPR002453,Beta tubulin","KOG1375,Beta tubulin;COG5023,Tubulin","GO:0043209,cellular_component,myelin sheath;GO:0005874,cellular_component,microtubule;GO:0005737,cellular_component,cytoplasm;GO:0005525,molecular_function,GTP binding;GO:0007017,biological_process,microtubule-based process;GO:0005856,cellular_component,cytoskeleton;GO:0003725,molecular_function,double-stranded RNA binding;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0007010,biological_process,cytoskeleton organization;GO:0005200,molecular_function,structural constituent of cytoskeleton","-"]
["TRIP4",5.983844171,2.612946133,1.191990525,3.834457073,1.862905E-3,0.004244017,"ENSG00000103671","H2Q9K9,Thyroid hormone receptor interactor 4","-","PF04266,ASCH domain;PF06221,Putative zinc finger motif, C2HC5-type","IPR009349,Zinc finger, C2HC5-type;IPR015947,PUA-like superfamily;IPR007374,ASCH domain","ENOG410XTTP,-;KOG2845,Activating signal cointegrator 1","GO:0030331,molecular_function,estrogen receptor binding;GO:0019901,molecular_function,protein kinase binding;GO:0032991,cellular_component,protein-containing complex;GO:0005737,cellular_component,cytoplasm;GO:0002020,molecular_function,protease binding;GO:0035035,molecular_function,histone acetyltransferase binding;GO:0003713,molecular_function,transcription coactivator activity;GO:0016922,molecular_function,ligand-dependent nuclear receptor binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0045661,biological_process,regulation of myoblast differentiation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0031594,cellular_component,neuromuscular junction;GO:0030520,biological_process,intracellular estrogen receptor signaling pathway;GO:0044389,molecular_function,ubiquitin-like protein ligase binding;GO:0005813,cellular_component,centrosome;GO:0099053,cellular_component,activating signal cointegrator 1 complex;GO:1901998,biological_process,toxin transport;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["NUP107",5.222981561,2.284192285,1.191721193,5.003281005,{"v":6.59e-05,"d":"6.59E-05"},2.07732E-4,"ENSG00000111581","G3RA29,Nucleoporin 107","XP_004053586.1,nuclear pore complex protein Nup107 isoform X1","PF04121,Nuclear pore protein 84 / 107","IPR007252,Nuclear pore protein 84/107","-","GO:0005643,cellular_component,nuclear pore;GO:0034399,cellular_component,nuclear periphery;GO:0000776,cellular_component,kinetochore;GO:0051292,biological_process,nuclear pore complex assembly;GO:0031080,cellular_component,nuclear pore outer ring;GO:0031965,cellular_component,nuclear membrane;GO:0006406,biological_process,mRNA export from nucleus;GO:0008585,biological_process,female gonad development;GO:0017056,molecular_function,structural constituent of nuclear pore","K14301,ko03013,RNA transport"]
["ZNF606",1.181857959,0.514991662,1.19135403,2.849405105,0.02594261,0.044123275,"ENSG00000166704","A0A024R4S7,Zinc finger protein 606, isoform CRA_a","NP_001334951.1,-;NP_079303.2,zinc finger protein 606 isoform 1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["DHX37",3.623976227,1.584350294,1.191022929,4.173287847,0.000851424,0.002088714,"ENSG00000150990","K7C6J6,DEAH","-","PF00271,Helicase conserved C-terminal domain;PF04408,Helicase associated domain (HA2);PF00270,AD/DEAH box helicase;PF07717,Oligonucleotide/oligosaccharide-binding (OB)-fold","IPR011709,Domain of unknown function DUF1605;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR007502,Helicase-associated domain;IPR011545,DEAD/DEAH box helicase domain;IPR001650,Helicase, C-terminal","-","GO:0003676,molecular_function,nucleic acid binding;GO:0016787,molecular_function,hydrolase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004386,molecular_function,helicase activity","-"]
["CSTF2T",10.75946091,4.709413705,1.190543903,5.026509591,{"v":5.57e-05,"d":"5.57E-05"},0.000178597,"ENSG00000177613","G3RT72,Uncharacterized protein","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF14304,Transcription termination and cleavage factor C-terminal;PF14327,Hinge domain of cleavage stimulation factor subunit 2","IPR026896,Transcription termination and cleavage factor, C-terminal domain;IPR025742,Cleavage stimulation factor subunit 2, hinge domain;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR038192,CSTF2, C-terminal domain superfamily;IPR035979,RNA-binding domain superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0031124,biological_process,mRNA 3'-end processing","-"]
["CEP68",3.993009517,1.747943694,1.189968442,4.677077787,0.00018864,0.000539023,"ENSG00000011523","K6ZRT4,Centrosomal protein 68kDa","XP_016804126.1,centrosomal protein of 68 kDa isoform X1;XP_016804127.1,-","-","IPR026696,A-kinase anchor protein 6/Centrosomal protein of 68kDa","ENOG41129RE,-;ENOG410IIDK,-","GO:0030054,cellular_component,cell junction;GO:0007098,biological_process,centrosome cycle;GO:0010457,biological_process,centriole-centriole cohesion;GO:0033365,biological_process,protein localization to organelle;GO:0019904,molecular_function,protein domain specific binding;GO:0019901,molecular_function,protein kinase binding;GO:0005815,cellular_component,microtubule organizing center;GO:0005813,cellular_component,centrosome;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["MCCC1-AS1",18.62432512,8.138046348,1.18996045,3.460027675,0.005161861,0.010553911,"-","-","-","-","-","-","-","-"]
["FAM3C2",36.26410442,15.8779643,1.188940456,4.214409087,0.000662286,0.001666902,"ENSG00000174028","K7DK62,Family with sequence similarity 3, member C","-","PF15711,Interleukin-like EMT inducer","-","ENOG410IEGC,-;ENOG4111I9K,-","-","-"]
["SNX4",11.04465792,4.838146107,1.1886974,4.481229131,0.000258465,7.14564E-4,"ENSG00000114520","H2QN95,Sorting nexin 4","XP_001169563.2,-","PF00787,PX domain","IPR036871,PX domain superfamily;IPR027267,AH/BAR domain superfamily;IPR034783,Sorting nexin-4;IPR034902,Sorting nexin 4, PX domain;IPR001683,Phox homologous domain;IPR037430,Sorting nexin-4, BAR domain","KOG2273,Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins;COG5391,Phox homology (PX) domain protein","GO:0031201,cellular_component,SNARE complex;GO:0019898,cellular_component,extrinsic component of membrane;GO:1990460,molecular_function,leptin receptor binding;GO:0016050,biological_process,vesicle organization;GO:0032991,cellular_component,protein-containing complex;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0005154,molecular_function,epidermal growth factor receptor binding;GO:0005868,cellular_component,cytoplasmic dynein complex;GO:0005158,molecular_function,insulin receptor binding;GO:0005768,cellular_component,endosome;GO:1903595,biological_process,positive regulation of histamine secretion by mast cell;GO:0005886,cellular_component,plasma membrane;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0016020,cellular_component,membrane;GO:1990459,molecular_function,transferrin receptor binding;GO:0032456,biological_process,endocytic recycling;GO:0031901,cellular_component,early endosome membrane;GO:0006897,biological_process,endocytosis","K17919,ko04144,Endocytosis"]
["AC015971.2",42.84245978,18.78909265,1.188627331,6.475919943,{"v":9.26e-07,"d":"9.26E-07"},{"v":4.4e-06,"d":"4.40E-06"},"ENSG00000228363","G1QRB1,Ring finger protein 103","-","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG0800,FOG: Predicted E3 ubiquitin ligase;ENOG41121N2,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SSFA2",68.89367605,30.22902165,1.188341065,8.894193617,{"v":2.67e-08,"d":"2.67E-08"},{"v":1.79E-7,"d":"1.79E-07"},"ENSG00000138434","K7CP33,Sperm specific antigen 2","XP_009442107.2,sperm-specific antigen 2 isoform X1","PF14722,Ki-ras-induced actin-interacting protein-IP3R-interacting domain;PF14723,Sperm-specific antigen 2 C-terminus","IPR029326,Sperm-specific antigen 2, C-terminal;IPR029325,IP3R-interacting domain;IPR026648,Sperm-specific antigen 2","ENOG410IERU,-;ENOG410ZSFW,-","GO:0005886,cellular_component,plasma membrane;GO:0003779,molecular_function,actin binding;GO:0005102,molecular_function,signaling receptor binding","-"]
["ZCCHC11",4.426999437,1.94182917,1.188027388,5.712802355,{"v":7.6e-06,"d":"7.60E-06"},{"v":2.97E-5,"d":"2.97E-05"},"ENSG00000134744","A0A0C4DFM7,Terminal uridylyltransferase 4","NP_001009881.1,terminal uridylyltransferase 4 isoform a","PF03828,Cid1 family poly A polymerase;PF00098,Zinc knuckle;PF01909,Nucleotidyltransferase domain","IPR001878,Zinc finger, CCHC-type;IPR002934,Polymerase, nucleotidyl transferase domain;IPR002058,PAP/25A-associated;IPR036875,Zinc finger, CCHC-type superfamily","COG5260,DNA polymerase sigma;KOG2277,S-M checkpoint control protein CID1 and related nucleotidyltransferases","GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0001816,biological_process,cytokine production;GO:0005730,cellular_component,nucleolus;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0031664,biological_process,regulation of lipopolysaccharide-mediated signaling pathway;GO:0031123,biological_process,RNA 3'-end processing;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0005634,cellular_component,nucleus;GO:0070102,biological_process,interleukin-6-mediated signaling pathway;GO:0010586,biological_process,miRNA metabolic process;GO:0008270,molecular_function,zinc ion binding;GO:0005829,cellular_component,cytosol;GO:0032755,biological_process,positive regulation of interleukin-6 production;GO:0050265,molecular_function,RNA uridylyltransferase activity","-"]
["MSH2",6.729428546,2.951274439,1.187074439,4.514505686,0.000337425,0.000906692,"ENSG00000095002","G3QW00,DNA mismatch repair protein","XP_004029250.1,DNA mismatch repair protein Msh2","PF01624,MutS domain I;PF05192,MutS domain III;PF05190,MutS family domain IV;PF00488,MutS domain V;PF05188,MutS domain II","IPR007695,DNA mismatch repair protein MutS-like, N-terminal;IPR011184,DNA mismatch repair Msh2-type;IPR007860,DNA mismatch repair protein MutS, connector domain;IPR036678,MutS, connector domain superfamily;IPR016151,DNA mismatch repair protein MutS, N-terminal;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR007696,DNA mismatch repair protein MutS, core;IPR007861,DNA mismatch repair protein MutS, clamp;IPR000432,DNA mismatch repair protein MutS, C-terminal;IPR036187,DNA mismatch repair protein MutS, core domain superfamily;IPR032642,DNA mismatch repair protein Msh2","-","GO:0031573,biological_process,intra-S DNA damage checkpoint;GO:0019901,molecular_function,protein kinase binding;GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0006119,biological_process,oxidative phosphorylation;GO:0032139,molecular_function,dinucleotide insertion or deletion binding;GO:0003684,molecular_function,damaged DNA binding;GO:0051096,biological_process,positive regulation of helicase activity;GO:0032357,molecular_function,oxidized purine DNA binding;GO:0030183,biological_process,B cell differentiation;GO:0016887,molecular_function,ATPase activity;GO:0003690,molecular_function,double-stranded DNA binding;GO:0005524,molecular_function,ATP binding;GO:0030983,molecular_function,mismatched DNA binding;GO:0043570,biological_process,maintenance of DNA repeat elements;GO:0007050,biological_process,cell cycle arrest;GO:0042803,molecular_function,protein homodimerization activity;GO:0032300,cellular_component,mismatch repair complex;GO:0032302,cellular_component,MutSbeta complex;GO:0006302,biological_process,double-strand break repair;GO:0008584,biological_process,male gonad development;GO:0045190,biological_process,isotype switching;GO:0016447,biological_process,somatic recombination of immunoglobulin gene segments;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0016446,biological_process,somatic hypermutation of immunoglobulin genes;GO:0032143,molecular_function,single thymine insertion binding;GO:0042771,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0032301,cellular_component,MutSalpha complex;GO:0003677,molecular_function,DNA binding;GO:0006298,biological_process,mismatch repair;GO:0005634,cellular_component,nucleus;GO:0010165,biological_process,response to X-ray;GO:0007281,biological_process,germ cell development;GO:0010224,biological_process,response to UV-B;GO:0008022,molecular_function,protein C-terminus binding;GO:0006281,biological_process,DNA repair;GO:0048304,biological_process,positive regulation of isotype switching to IgG isotypes;GO:0000166,molecular_function,nucleotide binding;GO:0003697,molecular_function,single-stranded DNA binding;GO:0019899,molecular_function,enzyme binding;GO:0032405,molecular_function,MutLalpha complex binding;GO:0000400,molecular_function,four-way junction DNA binding;GO:0032137,molecular_function,guanine/thymine mispair binding;GO:0043531,molecular_function,ADP binding;GO:0048298,biological_process,positive regulation of isotype switching to IgA isotypes;GO:0043524,biological_process,negative regulation of neuron apoptotic process;GO:0019237,molecular_function,centromeric DNA binding;GO:0008340,biological_process,determination of adult lifespan;GO:0002204,biological_process,somatic recombination of immunoglobulin genes involved in immune response;GO:0032181,molecular_function,dinucleotide repeat insertion binding;GO:0006301,biological_process,postreplication repair;GO:0001701,biological_process,in utero embryonic development;GO:0000287,molecular_function,magnesium ion binding;GO:0019724,biological_process,B cell mediated immunity;GO:0032142,molecular_function,single guanine insertion binding;GO:0045910,biological_process,negative regulation of DNA recombination","K08735,ko05200,Pathways in cancer;K08735,ko01524,Platinum drug resistance;K08735,ko03430,Mismatch repair;K08735,ko05210,Colorectal cancer"]
["MCTP2",1.152719152,0.504952142,1.1865803,3.527076305,0.004725737,0.009748914,"ENSG00000140563","K7BUQ5,Multiple C2 domains, transmembrane 2","-","PF00168,C2 domain;PF08372,Plant phosphoribosyltransferase C-terminal","-","-","-","-"]
["MTMR10",1.104215261,0.483114981,1.186063483,2.951027934,0.02294735,0.039785791,"ENSG00000166912","X5D963,Myotubularin related protein 10 isoform C","NP_060232.2,myotubularin-related protein 10","PF06602,Myotubularin-like phosphatase domain;PF12578,Myotubularin-associated protein","IPR036004,MTMR10, PH-GRAM domain;IPR030573,Myotubularin-related protein 10;IPR029021,Protein-tyrosine phosphatase-like;IPR010569,Myotubularin-like phosphatase domain;IPR022587,Myotubularin-related 12-like C-terminal domain;IPR030564,Myotubularin family","ENOG410XPTU,-;KOG1089,Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6","-","-"]
["GJC1",4.222732376,1.853984851,1.185815067,4.762613649,1.22872E-4,0.000364493,"ENSG00000182963","G3RJR0,Gap junction protein","-","PF00029,Connexin","-","-","-","-"]
["SLC25A44",5.828241602,2.560923676,1.184907871,4.974143553,{"v":7.83e-05,"d":"7.83E-05"},0.000242555,"ENSG00000160785","E9PGQ0,Solute carrier family 25 member 44","XP_006711720.1,-;XP_011508483.1,-;XP_011508482.1,-;NP_001273113.1,solute carrier family 25 member 44 isoform 1","PF00153,Mitochondrial carrier protein","IPR018108,Mitochondrial substrate/solute carrier;IPR023395,Mitochondrial carrier domain superfamily;IPR002067,Mitochondrial carrier protein","KOG0765,Predicted mitochondrial carrier protein;ENOG410XTGQ,-","GO:0055085,biological_process,transmembrane transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["AL078471.5",11.1754325,4.911022858,1.184538732,4.790031839,1.18972E-4,0.000353641,"ENSG00000273840","H2NJB3,Uncharacterized protein","-","PF10409,C2 domain of PTEN tumour-suppressor protein;PF00782,ual specificity phosphatase, catalytic domain","IPR014020,Tensin phosphatase, C2 domain;IPR016130,Protein-tyrosine phosphatase, active site;IPR029021,Protein-tyrosine phosphatase-like;IPR000340,Dual specificity phosphatase, catalytic domain;IPR027359,Voltage-dependent channel domain superfamily;IPR029023,Tensin-type phosphatase domain","KOG2283,Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases;COG2453,Predicted protein-tyrosine phosphatase","GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0006470,biological_process,protein dephosphorylation;GO:0016020,cellular_component,membrane;GO:0016311,biological_process,dephosphorylation;GO:0016021,cellular_component,integral component of membrane","-"]
["CPSF2",3.563212184,1.566614485,1.184223247,5.158523643,{"v":4.13e-05,"d":"4.13E-05"},0.000136765,"ENSG00000165934","H2Q8T2,Cleavage and polyadenylation specific factor 2, 100kDa","XP_016782110.1,-;XP_001147277.1,-","PF13299,Cleavage and polyadenylation factor 2 C-terminal;PF16661,Metallo-beta-lactamase superfamily domain;PF10996,Beta-Casp domain;PF07521,Zn-dependent metallo-hydrolase RNA specificity domain","IPR027075,Cleavage and polyadenylation specificity factor subunit 2;IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR001279,Metallo-beta-lactamase;IPR022712,Beta-Casp domain;IPR011108,Zn-dependent metallo-hydrolase, RNA specificity domain;IPR025069,Cleavage and polyadenylation specificity factor 2, C-terminal;IPR035639,CPSF2, metallo-hydrolase domain","KOG1135,mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit);COG1236,Predicted exonuclease of the beta-lactamase fold involved in RNA processing","GO:0005847,cellular_component,mRNA cleavage and polyadenylation specificity factor complex;GO:0006398,biological_process,mRNA 3'-end processing by stem-loop binding and cleavage;GO:0006397,biological_process,mRNA processing;GO:0003723,molecular_function,RNA binding;GO:0006378,biological_process,mRNA polyadenylation;GO:0006379,biological_process,mRNA cleavage;GO:0005634,cellular_component,nucleus","K14402,ko03015,mRNA surveillance pathway"]
["HNRNPK",107.725369,47.4131696,1.183883644,8.635117757,{"v":3.89e-08,"d":"3.89E-08"},{"v":2.52e-07,"d":"2.52E-07"},"ENSG00000165119","A0A287CYM1,Heterogeneous nuclear ribonucleoprotein K","XP_005340974.1,-;XP_005340973.1,-;XP_013220950.1,-;XP_005340976.1,-","-","IPR012987,ROK, N-terminal;IPR004087,K Homology domain;IPR004088,K Homology domain, type 1;IPR033090,Heterogeneous nuclear ribonucleoprotein K;IPR036612,K Homology domain, type 1 superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003677,molecular_function,DNA binding;GO:0006396,biological_process,RNA processing;GO:0003676,molecular_function,nucleic acid binding","-"]
["ZNF337-AS1",2.95259412,1.296332394,1.183513622,3.591122439,0.005012465,0.010292918,"ENSG00000213742","H2QK47,Uncharacterized protein","XP_003316905.1,zinc finger protein 337 isoform X1;XP_009435252.1,-;XP_016793080.1,-;XP_016793079.1,-;XP_016793081.1,-;XP_009435253.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["UNC93B1",7.562851301,3.324657278,1.183370424,4.331147733,0.000645736,0.001627794,"ENSG00000110057","K7DLU4,Unc-93 homolog B1","XP_016776874.1,protein unc-93 homolog B1","PF05978,Ion channel regulatory protein UNC-93","IPR010291,Ion channel regulatory protein, UNC-93","ENOG410XTFP,-;KOG3097,Predicted membrane protein","GO:0005768,cellular_component,endosome;GO:0034162,biological_process,toll-like receptor 9 signaling pathway;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0034154,biological_process,toll-like receptor 7 signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0034138,biological_process,toll-like receptor 3 signaling pathway","-"]
["FADD",124.0829222,54.64023772,1.182992698,7.369835466,{"v":1.82e-07,"d":"1.82E-07"},{"v":1.01e-06,"d":"1.01E-06"},"ENSG00000168040","G3RWC4,FAS-associated death domain protein","XP_004051748.1,FAS-associated death domain protein","PF01335,eath effector domain;PF00531,eath domain","IPR016729,FADD;IPR001875,Death effector domain;IPR011029,Death-like domain superfamily;IPR000488,Death domain","-","GO:0002821,biological_process,positive regulation of adaptive immune response;GO:0051607,biological_process,defense response to virus;GO:0097202,biological_process,activation of cysteine-type endopeptidase activity;GO:0032813,molecular_function,tumor necrosis factor receptor superfamily binding;GO:0031264,cellular_component,death-inducing signaling complex;GO:0002020,molecular_function,protease binding;GO:0032760,biological_process,positive regulation of tumor necrosis factor production;GO:0071260,biological_process,cellular response to mechanical stimulus;GO:0005886,cellular_component,plasma membrane;GO:0070236,biological_process,negative regulation of activation-induced cell death of T cells;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0097342,cellular_component,ripoptosome;GO:0045862,biological_process,positive regulation of proteolysis;GO:0097049,biological_process,motor neuron apoptotic process;GO:2001238,biological_process,positive regulation of extrinsic apoptotic signaling pathway;GO:0001916,biological_process,positive regulation of T cell mediated cytotoxicity;GO:0042104,biological_process,positive regulation of activated T cell proliferation;GO:0043029,biological_process,T cell homeostasis;GO:0042802,molecular_function,identical protein binding;GO:0045651,biological_process,positive regulation of macrophage differentiation;GO:0006915,biological_process,apoptotic process;GO:0060340,biological_process,positive regulation of type I interferon-mediated signaling pathway;GO:0089720,molecular_function,caspase binding;GO:0042981,biological_process,regulation of apoptotic process;GO:0036462,biological_process,TRAIL-activated apoptotic signaling pathway;GO:0097191,biological_process,extrinsic apoptotic signaling pathway;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0033077,biological_process,T cell differentiation in thymus;GO:0032729,biological_process,positive regulation of interferon-gamma production;GO:0060546,biological_process,negative regulation of necroptotic process;GO:0097527,biological_process,necroptotic signaling pathway;GO:0005829,cellular_component,cytosol;GO:0097190,biological_process,apoptotic signaling pathway;GO:0007165,biological_process,signal transduction;GO:0048535,biological_process,lymph node development;GO:2000454,biological_process,positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation;GO:0048538,biological_process,thymus development;GO:0035877,molecular_function,death effector domain binding;GO:0032757,biological_process,positive regulation of interleukin-8 production;GO:0045087,biological_process,innate immune response;GO:0048536,biological_process,spleen development;GO:0097192,biological_process,extrinsic apoptotic signaling pathway in absence of ligand;GO:0005737,cellular_component,cytoplasm;GO:1902043,biological_process,positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0031265,cellular_component,CD95 death-inducing signaling complex;GO:0002376,biological_process,immune system process;GO:0043065,biological_process,positive regulation of apoptotic process","K02373,ko05152,Tuberculosis;K02373,ko05161,Hepatitis B;K02373,ko05168,Herpes simplex infection;K02373,ko04668,TNF signaling pathway;K02373,ko04210,Apoptosis;K02373,ko04620,Toll-like receptor signaling pathway;K02373,ko04215,Apoptosis - multiple species;K02373,ko05200,Pathways in cancer;K02373,ko05142,Chagas disease (American trypanosomiasis);K02373,ko04622,RIG-I-like receptor signaling pathway;K02373,ko05010,Alzheimer's disease;K02373,ko01524,Platinum drug resistance"]
["GZF1",3.955495739,1.739381275,1.182364031,4.031606531,1.328419E-3,3.110921E-3,"ENSG00000125812","H2R1H8,GDNF inducible zinc finger protein 1","-","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF13912,C2H2-type zinc finger;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["DHX9",18.97157228,8.358465207,1.181940835,6.285635976,{"v":1.63e-06,"d":"1.63E-06"},{"v":7.4e-06,"d":"7.40E-06"},"ENSG00000135829","H2Q0R0,DEAH","XP_003308679.1,-","PF04408,Helicase associated domain (HA2);PF00271,Helicase conserved C-terminal domain;PF00035,ouble-stranded RNA binding motif;PF00270,AD/DEAH box helicase;PF07717,Oligonucleotide/oligosaccharide-binding (OB)-fold","IPR011709,Domain of unknown function DUF1605;IPR014720,Double-stranded RNA-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR007502,Helicase-associated domain;IPR011545,DEAD/DEAH box helicase domain;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR001650,Helicase, C-terminal","KOG0920,ATP-dependent RNA helicase A;COG1643,HrpA-like helicases","GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:1904973,biological_process,positive regulation of viral translation;GO:0032991,cellular_component,protein-containing complex;GO:2000778,biological_process,positive regulation of interleukin-6 secretion;GO:1905698,biological_process,positive regulation of polysome binding;GO:0050434,biological_process,positive regulation of viral transcription;GO:0005844,cellular_component,polysome;GO:0004004,molecular_function,ATP-dependent RNA helicase activity;GO:0070937,cellular_component,CRD-mediated mRNA stability complex;GO:1904469,biological_process,positive regulation of tumor necrosis factor secretion;GO:0044806,biological_process,G-quadruplex DNA unwinding;GO:0050684,biological_process,regulation of mRNA processing;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0033681,molecular_function,ATP-dependent 3'-5' DNA/RNA helicase activity;GO:0032508,biological_process,DNA duplex unwinding;GO:0070578,cellular_component,RISC-loading complex;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005524,molecular_function,ATP binding;GO:0030423,biological_process,targeting of mRNA for destruction involved in RNA interference;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0016787,molecular_function,hydrolase activity;GO:0097165,cellular_component,nuclear stress granule;GO:1905172,molecular_function,RISC complex binding;GO:0003727,molecular_function,single-stranded RNA binding;GO:0070063,molecular_function,RNA polymerase binding;GO:0005737,cellular_component,cytoplasm;GO:0000166,molecular_function,nucleotide binding;GO:0061676,molecular_function,importin-alpha family protein binding;GO:0071360,biological_process,cellular response to exogenous dsRNA;GO:0005634,cellular_component,nucleus;GO:0006366,biological_process,transcription by RNA polymerase II;GO:1905538,molecular_function,polysome binding;GO:0001105,molecular_function,RNA polymerase II transcription coactivator activity;GO:0003729,molecular_function,mRNA binding;GO:0015629,cellular_component,actin cytoskeleton;GO:1902741,biological_process,positive regulation of interferon-alpha secretion;GO:0047429,molecular_function,nucleoside-triphosphate diphosphatase activity;GO:0005654,cellular_component,nucleoplasm;GO:0001047,molecular_function,core promoter binding;GO:0003676,molecular_function,nucleic acid binding;GO:0043140,molecular_function,ATP-dependent 3'-5' DNA helicase activity;GO:2000767,biological_process,positive regulation of cytoplasmic translation;GO:0035068,cellular_component,micro-ribonucleoprotein complex;GO:0000380,biological_process,alternative mRNA splicing, via spliceosome;GO:0000993,molecular_function,RNA polymerase II core binding;GO:2000373,biological_process,positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:1903608,biological_process,protein localization to cytoplasmic stress granule;GO:0039695,biological_process,DNA-templated viral transcription;GO:0005726,cellular_component,perichromatin fibrils;GO:0045739,biological_process,positive regulation of DNA repair;GO:0005813,cellular_component,centrosome;GO:2000765,biological_process,regulation of cytoplasmic translation;GO:0070922,biological_process,small RNA loading onto RISC;GO:0045142,molecular_function,triplex DNA binding;GO:0016604,cellular_component,nuclear body;GO:0001069,molecular_function,regulatory region RNA binding;GO:0001085,molecular_function,RNA polymerase II transcription factor binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0035197,molecular_function,siRNA binding;GO:1990518,molecular_function,single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity;GO:0042788,cellular_component,polysomal ribosome;GO:0035549,biological_process,positive regulation of interferon-beta secretion;GO:0070934,biological_process,CRD-mediated mRNA stabilization;GO:0035613,molecular_function,RNA stem-loop binding;GO:0003697,molecular_function,single-stranded DNA binding;GO:1990825,molecular_function,sequence-specific mRNA binding;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity;GO:0034459,molecular_function,ATP-dependent 3'-5' RNA helicase activity;GO:0048146,biological_process,positive regulation of fibroblast proliferation;GO:0003725,molecular_function,double-stranded RNA binding;GO:0010501,biological_process,RNA secondary structure unwinding;GO:0031490,molecular_function,chromatin DNA binding;GO:0003690,molecular_function,double-stranded DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003723,molecular_function,RNA binding;GO:0060760,biological_process,positive regulation of response to cytokine stimulus;GO:0003688,molecular_function,DNA replication origin binding;GO:0045740,biological_process,positive regulation of DNA replication;GO:0006396,biological_process,RNA processing;GO:0046833,biological_process,positive regulation of RNA export from nucleus;GO:0016887,molecular_function,ATPase activity;GO:0004386,molecular_function,helicase activity;GO:2000637,biological_process,positive regulation of gene silencing by miRNA;GO:0030529,,;GO:0004003,molecular_function,ATP-dependent DNA helicase activity","-"]
["BBS4",2.518256542,1.105637077,1.181507579,3.045883637,0.015645122,0.028417262,"ENSG00000140463","K7A0P4,Bardet-Biedl syndrome 4","-","PF13414,TPR repeat;PF13181,Tetratricopeptide repeat","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","KOG1124,FOG: TPR repeat;COG0457,FOG: TPR repeat","GO:0060170,cellular_component,ciliary membrane;GO:0034451,cellular_component,centriolar satellite;GO:0097730,cellular_component,non-motile cilium;GO:0007608,biological_process,sensory perception of smell;GO:0001103,molecular_function,RNA polymerase II repressing transcription factor binding;GO:0048854,biological_process,brain morphogenesis;GO:0060296,biological_process,regulation of cilium beat frequency involved in ciliary motility;GO:0043014,molecular_function,alpha-tubulin binding;GO:0032391,cellular_component,photoreceptor connecting cilium;GO:0033210,biological_process,leptin-mediated signaling pathway;GO:0000281,biological_process,mitotic cytokinesis;GO:0061512,biological_process,protein localization to cilium;GO:0035176,biological_process,social behavior;GO:0001917,cellular_component,photoreceptor inner segment;GO:0005634,cellular_component,nucleus;GO:0034452,molecular_function,dynactin binding;GO:0016358,biological_process,dendrite development;GO:0007098,biological_process,centrosome cycle;GO:0035869,cellular_component,ciliary transition zone;GO:0021987,biological_process,cerebral cortex development;GO:0001895,biological_process,retina homeostasis;GO:0033365,biological_process,protein localization to organelle;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0000242,cellular_component,pericentriolar material;GO:0003085,biological_process,negative regulation of systemic arterial blood pressure;GO:0048487,molecular_function,beta-tubulin binding;GO:1905515,biological_process,non-motile cilium assembly;GO:0036064,cellular_component,ciliary basal body;GO:0008104,biological_process,protein localization;GO:0060324,biological_process,face development;GO:0005829,cellular_component,cytosol;GO:1902855,biological_process,regulation of non-motile cilium assembly;GO:0030534,biological_process,adult behavior;GO:0045444,biological_process,fat cell differentiation;GO:0071539,biological_process,protein localization to centrosome;GO:0021591,biological_process,ventricular system development;GO:0034464,cellular_component,BBSome;GO:0040018,biological_process,positive regulation of multicellular organism growth;GO:0035845,biological_process,photoreceptor cell outer segment organization;GO:0019216,biological_process,regulation of lipid metabolic process;GO:0005814,cellular_component,centriole;GO:0051457,biological_process,maintenance of protein location in nucleus;GO:0051492,biological_process,regulation of stress fiber assembly;GO:0060613,biological_process,fat pad development;GO:0005813,cellular_component,centrosome;GO:0034454,biological_process,microtubule anchoring at centrosome;GO:0010629,biological_process,negative regulation of gene expression;GO:0016020,cellular_component,membrane;GO:0001843,biological_process,neural tube closure;GO:0060271,biological_process,cilium assembly;GO:0003777,molecular_function,microtubule motor activity;GO:0001764,biological_process,neuron migration;GO:0007286,biological_process,spermatid development;GO:0038108,biological_process,negative regulation of appetite by leptin-mediated signaling pathway;GO:1903546,biological_process,protein localization to photoreceptor outer segment;GO:0030837,biological_process,negative regulation of actin filament polymerization;GO:0005929,cellular_component,cilium;GO:0001750,cellular_component,photoreceptor outer segment;GO:0045724,biological_process,positive regulation of cilium assembly;GO:0031514,cellular_component,motile cilium;GO:0046548,biological_process,retinal rod cell development;GO:0032465,biological_process,regulation of cytokinesis;GO:0021766,biological_process,hippocampus development;GO:0045494,biological_process,photoreceptor cell maintenance;GO:0021756,biological_process,striatum development;GO:0044321,biological_process,response to leptin;GO:0034260,biological_process,negative regulation of GTPase activity","-"]
["ZBTB45",3.056830425,1.3420972,1.181507579,3.045883637,0.015645122,0.028417262,"ENSG00000119574","A0A024R4T8,Zinc finger protein 499, isoform CRA_a","NP_001303908.1,-;NP_001303909.1,-;XP_006723508.1,-;NP_001303907.1,-;NP_001303911.1,-;NP_116181.1,zinc finger and BTB domain-containing protein 45;NP_001303910.1,-","PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["DNAJC5",9.566675042,4.214320837,1.181471914,5.220254318,{"v":3.81e-05,"d":"3.81E-05"},1.26919E-4,"ENSG00000101152","A0A250YBR5,DnaJ subfamily C member 5","XP_020016621.1,-;XP_020016620.1,-;XP_020016622.1,-","-","IPR036869,Chaperone J-domain superfamily;IPR018253,DnaJ domain, conserved site;IPR001623,DnaJ domain","-","-","K09525,ko04141,Protein processing in endoplasmic reticulum"]
["CGGBP1",6.988426464,3.079733459,1.180774294,5.066691634,{"v":5.31e-05,"d":"5.31E-05"},0.000171167,"ENSG00000163320","K9J4V2,Putative cgg triplet repeat-binding protein 1-like isoform 2","-","-","IPR033375,CGG triplet repeat-binding protein 1","-","GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus;GO:0003690,molecular_function,double-stranded DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II","-"]
["BRCA1",5.748867001,2.534048163,1.180606804,5.240257049,{"v":3.27e-05,"d":"3.27E-05"},0.000110687,"ENSG00000012048","G8I0D8,Breast cancer type 1 susceptibility protein","-","PF12820,Serine-rich domain associated with BRCT;PF00533,BRCA1 C Terminus (BRCT) domain;PF00097,Zinc finger, C3HC4 type (RING finger)","IPR017907,Zinc finger, RING-type, conserved site;IPR036420,BRCT domain superfamily;IPR025994,BRCA1, serine-rich domain;IPR001841,Zinc finger, RING-type;IPR031099,BRCA1-associated;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011364,Breast cancer type 1 susceptibility protein (BRCA1);IPR018957,Zinc finger, C3HC4 RING-type;IPR001357,BRCT domain","ENOG410ITQ4,-;ENOG4112BIH,-","GO:0085020,biological_process,protein K6-linked ubiquitination;GO:0003677,molecular_function,DNA binding;GO:0005694,cellular_component,chromosome;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0031436,cellular_component,BRCA1-BARD1 complex;GO:0046872,molecular_function,metal ion binding;GO:0007049,biological_process,cell cycle;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0051865,biological_process,protein autoubiquitination;GO:0006281,biological_process,DNA repair;GO:0006310,biological_process,DNA recombination;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["RP11-732A19.2",65.86889811,29.02380166,1.18013446,4.404015729,0.000405123,1.071958E-3,"ENSG00000254641","A0A0A0MTH3,Integrin-linked protein kinase","-","PF12796,Ankyrin repeats (3 copies);PF13857,Ankyrin repeats (many copies);PF07714,Protein tyrosine kinase","IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR002110,Ankyrin repeat;IPR011009,Protein kinase-like domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR035692,Integrin-linked protein kinase, pseudokinase domain;IPR000719,Protein kinase domain","-","GO:0030054,cellular_component,cell junction;GO:0004672,molecular_function,protein kinase activity;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0005925,cellular_component,focal adhesion;GO:0005524,molecular_function,ATP binding;GO:0005654,cellular_component,nucleoplasm","-"]
["VARS2",5.453038374,2.404726988,1.179822421,5.088928284,{"v":5.82e-05,"d":"5.82E-05"},0.000186048,"ENSG00000137411","A0A1U9X9B3,VARS2","NP_001161206.1,valine--tRNA ligase, mitochondrial isoform 1","-","IPR002303,Valine-tRNA ligase;IPR002300,Aminoacyl-tRNA synthetase, class Ia;IPR009008,Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain;IPR013155,Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding;IPR009080,Aminoacyl-tRNA synthetase, class Ia, anticodon-binding;IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR001412,Aminoacyl-tRNA synthetase, class I, conserved site;IPR033705,Valyl tRNA synthetase, anticodon-binding domain","-","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0002161,molecular_function,aminoacyl-tRNA editing activity;GO:0006438,biological_process,valyl-tRNA aminoacylation;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0005524,molecular_function,ATP binding;GO:0005739,cellular_component,mitochondrion;GO:0004832,molecular_function,valine-tRNA ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0006412,biological_process,translation;GO:0106074,biological_process,aminoacyl-tRNA metabolism involved in translational fidelity;GO:0016874,molecular_function,ligase activity","-"]
["RBM7",2.921196461,1.288213925,1.178460969,4.120870846,1.10001E-3,0.002633903,"ENSG00000076053","J3KPD3,RNA binding motif protein 7, isoform CRA_c","NP_001272974.1,RNA-binding protein 7 isoform a","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR034500,RBM7, RNA recognition motif;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain","ENOG41123B7,-;KOG4454,RNA binding protein (RRM superfamily)","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["ARMT1",8.170852817,3.603251791,1.178460969,4.120870846,1.10001E-3,0.002633903,"ENSG00000146476","G3S2Y4,Acidic residue methyltransferase 1","XP_004044880.1,protein-glutamate O-methyltransferase isoform X1","PF01937,Protein of unknown function DUF89","IPR036075,AF1104-like superfamily;IPR002791,Domain of unknown function DUF89","-","GO:0019899,molecular_function,enzyme binding;GO:0051998,molecular_function,protein carboxyl O-methyltransferase activity;GO:0006479,biological_process,protein methylation;GO:0008757,molecular_function,S-adenosylmethionine-dependent methyltransferase activity;GO:2001020,biological_process,regulation of response to DNA damage stimulus;GO:0032259,biological_process,methylation","-"]
["EPPK1",1.068437099,0.470957333,1.17816104,3.711208741,3.379487E-3,0.007224506,"ENSG00000261150","A0A087X1U6,Epiplakin","-","PF00681,Plectin repeat","IPR035915,Plakin repeat superfamily;IPR030269,Plectin;IPR001101,Plectin repeat","-","GO:0005856,cellular_component,cytoskeleton;GO:0045111,cellular_component,intermediate filament cytoskeleton;GO:0008092,molecular_function,cytoskeletal protein binding","-"]
["CTC-459F4.3",2.170905821,0.956030281,1.177543214,3.134820654,0.010772886,0.020317362,"-","-","-","-","-","-","-","-"]
["LSM11",1.695113431,0.746499343,1.177543214,3.134820654,0.010772886,0.020317362,"ENSG00000155858","G3R003,LSM11, U7 small nuclear RNA associated","-","-","-","-","-","-"]
["RP11-295K3.1",22.03187535,9.74742514,1.175908618,6.271527252,{"v":1.91e-06,"d":"1.91E-06"},{"v":8.55e-06,"d":"8.55E-06"},"ENSG00000250644","A0A1B0GU03,Uncharacterized protein","-","PF00026,ukaryotic aspartyl protease;PF07966,A1 Propeptide;PF04505,Interferon-induced transmembrane protein","IPR012848,Aspartic peptidase, N-terminal;IPR033121,Peptidase family A1 domain;IPR007593,CD225/Dispanin family;IPR021109,Aspartic peptidase domain superfamily;IPR001461,Aspartic peptidase A1 family;IPR001969,Aspartic peptidase, active site","-","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0004190,molecular_function,aspartic-type endopeptidase activity;GO:0009607,biological_process,response to biotic stimulus;GO:0008233,molecular_function,peptidase activity;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["JRK",2.178145424,0.9629436,1.17502076,4.204906819,0.000804098,0.001981677,"ENSG00000234616","Q86XJ5,JRK protein","-","PF03184,superfamily endonuclease;PF03221,Tc5 transposase DNA-binding domain;PF04218,CENP-B N-terminal DNA-binding domain","IPR006600,HTH CenpB-type DNA-binding domain;IPR009057,Homeobox-like domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR004875,DDE superfamily endonuclease domain;IPR007889,DNA binding HTH domain, Psq-type","-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0003729,molecular_function,mRNA binding;GO:0005634,cellular_component,nucleus;GO:0030529,,","-"]
["ATF1",11.14956238,4.93256799,1.174567832,4.539524819,3.22904E-4,0.000872189,"ENSG00000123268","B2R8K4,cDNA, FLJ93942, highly similar to Homo sapiens activating transcription factor 1","-","PF00170,bZIP transcription factor;PF02173,pKID domain","IPR003102,Coactivator CBP, pKID;IPR001630,cAMP response element binding (CREB) protein;IPR029825,cAMP-dependent transcription factor ATF1;IPR004827,Basic-leucine zipper domain","ENOG410ZZJZ,-;KOG3584,cAMP response element binding protein and related transcription factors","GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005634,cellular_component,nucleus","-"]
["PRCP",0.927723649,0.409643313,1.174062192,3.218537095,0.014497319,0.026554217,"ENSG00000137509","G3RK45,Prolylcarboxypeptidase","XP_004051943.1,lysosomal Pro-X carboxypeptidase isoform X1","PF05577,Serine carboxypeptidase S28","IPR008758,Peptidase S28;IPR029058,Alpha/Beta hydrolase fold","-","GO:0006508,biological_process,proteolysis;GO:0043535,biological_process,regulation of blood vessel endothelial cell migration;GO:0042593,biological_process,glucose homeostasis;GO:0002155,biological_process,regulation of thyroid hormone mediated signaling pathway;GO:0045178,cellular_component,basal part of cell;GO:0003085,biological_process,negative regulation of systemic arterial blood pressure;GO:0002353,biological_process,plasma kallikrein-kinin cascade;GO:2000377,biological_process,regulation of reactive oxygen species metabolic process;GO:0008236,molecular_function,serine-type peptidase activity;GO:0060055,biological_process,angiogenesis involved in wound healing;GO:0097009,biological_process,energy homeostasis","-"]
["SPHK2",1.975870738,0.872460496,1.174062192,3.218537095,0.014497319,0.026554217,"ENSG00000063176","M0R344,Sphingosine kinase 2","-","PF00781,iacylglycerol kinase catalytic domain","IPR017438,Inorganic polyphosphate/ATP-NAD kinase, N-terminal;IPR001206,Diacylglycerol kinase, catalytic domain;IPR016064,NAD kinase/diacylglycerol kinase-like domain superfamily","COG1597,Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase;KOG1116,Sphingosine kinase, involved in sphingolipid metabolism","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016301,molecular_function,kinase activity;GO:0003951,molecular_function,NAD+ kinase activity;GO:0016310,biological_process,phosphorylation;GO:0008152,biological_process,metabolic process","-"]
["USO1",21.11676968,9.355691217,1.173829044,6.14512546,{"v":2.94e-06,"d":"2.94E-06"},{"v":1.26E-5,"d":"1.26E-05"},"ENSG00000138768","H2PDM7,USO1 vesicle transport factor","-","PF04871,Uso1 / p115 like vesicle tethering protein, C terminal region;PF04869,Uso1 / p115 like vesicle tethering protein, head region","IPR000225,Armadillo;IPR006953,Vesicle tethering protein Uso1/P115-like , head domain;IPR006955,Uso1/p115-like vesicle tethering protein, C-terminal;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","ENOG410XRCG,-;KOG0946,ER-Golgi vesicle-tethering protein p115","GO:0005794,cellular_component,Golgi apparatus;GO:0005737,cellular_component,cytoplasm;GO:0016020,cellular_component,membrane;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0048280,biological_process,vesicle fusion with Golgi apparatus;GO:0000139,cellular_component,Golgi membrane;GO:0007030,biological_process,Golgi organization;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol;GO:0001650,cellular_component,fibrillar center;GO:0008565,molecular_function,protein transporter activity;GO:0006886,biological_process,intracellular protein transport","-"]
["TOP3A",6.966866523,3.086391314,1.173206833,5.061491997,{"v":6.11e-05,"d":"6.11E-05"},0.000194659,"ENSG00000177302","H2R419,DNA topoisomerase","XP_511323.2,DNA topoisomerase 3-alpha isoform X1","PF01396,Topoisomerase DNA binding C4 zinc finger;PF01751,Toprim domain;PF06839,RF zinc finger;PF01131,NA topoisomerase","IPR023405,DNA topoisomerase, type IA, core domain;IPR023406,DNA topoisomerase, type IA, active site;IPR000380,DNA topoisomerase, type IA;IPR034144,DNA topoisomerase 3-like, TOPRIM domain;IPR003601,DNA topoisomerase, type IA, domain 2;IPR006171,TOPRIM  domain;IPR013498,DNA topoisomerase, type IA, zn finger;IPR013497,DNA topoisomerase, type IA, central;IPR013824,DNA topoisomerase, type IA, central region, subdomain 1;IPR010666,Zinc finger, GRF-type;IPR013826,DNA topoisomerase, type IA, central region, subdomain 3;IPR003602,DNA topoisomerase, type IA, DNA-binding domain;IPR013825,DNA topoisomerase, type IA, central region, subdomain 2","COG0550,Topoisomerase IA;KOG1956,DNA topoisomerase III alpha","GO:0016605,cellular_component,PML body;GO:0003677,molecular_function,DNA binding;GO:0005694,cellular_component,chromosome;GO:0003917,molecular_function,DNA topoisomerase type I activity;GO:0006265,biological_process,DNA topological change;GO:0016853,molecular_function,isomerase activity;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0003916,molecular_function,DNA topoisomerase activity","-"]
["PRPF4",32.92763155,14.60111117,1.172696917,6.438534906,{"v":1.32e-06,"d":"1.32E-06"},{"v":6.1E-6,"d":"6.10E-06"},"ENSG00000136875","H2QXQ4,PRP4 pre-mRNA processing factor 4 homolog","XP_009455386.1,-","PF08799,pre-mRNA processing factor 4 (PRP4) like;PF00400,WD domain, G-beta repeat","IPR036285,PRP4-like superfamily;IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR027106,U4/U6 small nuclear ribonucleoprotein Prp4;IPR020472,G-protein beta WD-40 repeat;IPR014906,Pre-mRNA processing factor 4 (PRP4)-like;IPR001680,WD40 repeat","ENOG410XNP8,-;KOG0272,U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)","GO:0046540,cellular_component,U4/U6 x U5 tri-snRNP complex;GO:0017070,molecular_function,U6 snRNA binding;GO:0030621,molecular_function,U4 snRNA binding;GO:0000398,biological_process,mRNA splicing, via spliceosome","K12662,ko03040,Spliceosome"]
["SH3BP1",5.272615868,2.3366599,1.172156497,4.602772282,0.000250346,0.000695223,"ENSG00000100092","K7AQ69,SH3-domain binding protein 1","-","PF03114,BAR domain;PF00620,RhoGAP domain","-","-","-","-"]
["AF127936.9",2.122683033,0.939497144,1.170981188,3.297614281,0.01019156,0.019375402,"ENSG00000235609","Q95KE1,Uncharacterized protein","-","-","-","-","-","-"]
["PARP1",38.38977659,17.04818873,1.170877868,7.640997407,{"v":1.64e-07,"d":"1.64E-07"},{"v":9.14e-07,"d":"9.14E-07"},"ENSG00000143799","A0A024R3T8,Poly [ADP-ribose] polymerase","NP_001609.2,poly","PF05406,WGR domain;PF02877,Poly(ADP-ribose) polymerase, regulatory domain;PF00533,BRCA1 C Terminus (BRCT) domain;PF00645,Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region;PF00644,Poly(ADP-ribose) polymerase catalytic domain;PF08063,PADR1 (NUC008) domain","IPR036616,Poly(ADP-ribose) polymerase, regulatory domain superfamily;IPR038650,PADR1 domain superfamily;IPR001357,BRCT domain;IPR012982,PADR1 domain;IPR008288,Poly [ADP-ribose] polymerase;IPR001510,Zinc finger, PARP-type;IPR004102,Poly(ADP-ribose) polymerase, regulatory domain;IPR036930,WGR domain superfamily;IPR008893,WGR domain;IPR012317,Poly(ADP-ribose) polymerase, catalytic domain;IPR036420,BRCT domain superfamily;IPR036957,Zinc finger, PARP-type superfamily","ENOG410XP18,-;KOG1037,NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:1901216,biological_process,positive regulation of neuron death;GO:1903376,biological_process,regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:0007179,biological_process,transforming growth factor beta receptor signaling pathway;GO:0003950,molecular_function,NAD+ ADP-ribosyltransferase activity;GO:1904044,biological_process,response to aldosterone;GO:0060391,biological_process,positive regulation of SMAD protein signal transduction;GO:0046332,molecular_function,SMAD binding;GO:0006471,biological_process,protein ADP-ribosylation;GO:0070412,molecular_function,R-SMAD binding;GO:0005634,cellular_component,nucleus;GO:0051287,molecular_function,NAD binding;GO:0030331,molecular_function,estrogen receptor binding;GO:0042826,molecular_function,histone deacetylase binding;GO:0042769,biological_process,DNA damage response, detection of DNA damage;GO:1904646,biological_process,cellular response to amyloid-beta;GO:0044030,biological_process,regulation of DNA methylation;GO:0033148,biological_process,positive regulation of intracellular estrogen receptor signaling pathway;GO:0016540,biological_process,protein autoprocessing;GO:0071294,biological_process,cellular response to zinc ion;GO:1900182,biological_process,positive regulation of protein localization to nucleus;GO:0003677,molecular_function,DNA binding;GO:0010990,biological_process,regulation of SMAD protein complex assembly;GO:0016740,molecular_function,transferase activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:1904762,biological_process,positive regulation of myofibroblast differentiation;GO:0071560,biological_process,cellular response to transforming growth factor beta stimulus;GO:2000679,biological_process,positive regulation of transcription regulatory region DNA binding;GO:0008270,molecular_function,zinc ion binding;GO:0023019,biological_process,signal transduction involved in regulation of gene expression;GO:0019899,molecular_function,enzyme binding;GO:0051901,biological_process,positive regulation of mitochondrial depolarization;GO:0010613,biological_process,positive regulation of cardiac muscle hypertrophy;GO:0010332,biological_process,response to gamma radiation;GO:0070212,biological_process,protein poly-ADP-ribosylation","K10798,ko04214,Apoptosis - fly;K10798,ko04212,Longevity regulating pathway - worm;K10798,ko04210,Apoptosis;K10798,ko03410,Base excision repair"]
["RABGEF1",7.191938513,3.191903911,1.170433017,4.914028667,{"v":9.89e-05,"d":"9.89E-05"},0.000299347,"ENSG00000154710","E9PFK9,Rab5 GDP/GTP exchange factor","-","PF01754,A20-like zinc finger;PF02204,Vacuolar sorting protein 9 (VPS9) domain","IPR037191,VPS9 domain superfamily;IPR002653,Zinc finger, A20-type;IPR003123,VPS9 domain","ENOG410YGAZ,-;KOG2319,Vacuolar assembly/sorting protein VPS9;KOG3173,Predicted Zn-finger protein","GO:0005515,molecular_function,protein binding;GO:0005829,cellular_component,cytosol;GO:0003677,molecular_function,DNA binding;GO:0008270,molecular_function,zinc ion binding;GO:0005730,cellular_component,nucleolus","-"]
["TTI2",8.04282349,3.569994901,1.16995084,4.663354816,1.95835E-4,0.000557997,"ENSG00000129696","G2HGH8,Chromosome 8 open reading frame 41","NP_001233468.1,TELO2-interacting protein 2","PF10521,Tti2 family","IPR016024,Armadillo-type fold;IPR018870,Tti2 family","ENOG4111H5A,-;ENOG410IDZC,-","GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm;GO:0005813,cellular_component,centrosome","-"]
["RP11-226E21.4",3.245997104,1.439692924,1.169785835,3.924833628,0.002305017,0.005150603,"ENSG00000283208","A0A1B0GWJ7,Uncharacterized protein","-","PF15014,Ceroid-lipofuscinosis neuronal protein 5","IPR026138,Ceroid-lipofuscinosis neuronal protein 5","-","GO:0005764,cellular_component,lysosome","-"]
["PIGL",4.431664509,1.967469566,1.169234456,4.359523365,0.00061266,0.001551082,"ENSG00000108474","H2QCB7,Phosphatidylinositol glycan anchor biosynthesis class L","-","PF02585,lcNAc-PI de-N-acetylase","IPR024078,Putative deacetylase LmbE-like domain superfamily;IPR003737,N-acetylglucosaminyl phosphatidylinositol deacetylase-related","KOG3332,N-acetylglucosaminyl phosphatidylinositol de-N-acetylase;COG2120,Uncharacterized proteins, LmbE homologs","-","-"]
["TRAPPC6B",9.272103621,4.120188919,1.168710834,4.963021792,1.04826E-4,0.000315792,"ENSG00000182400","H0VDD7,Trafficking protein particle complex 6B","XP_003471956.1,-","PF04051,Transport protein particle (TRAPP) component","IPR007194,Transport protein particle (TRAPP) component;IPR037992,TRAPP complex, Trs33 subunit;IPR024096,NO signalling/Golgi transport ligand-binding domain superfamily","ENOG410YUYH,-;KOG3316,Transport protein particle (TRAPP) complex subunit","GO:0048193,biological_process,Golgi vesicle transport;GO:0043087,biological_process,regulation of GTPase activity","-"]
["NAIF1",3.672402136,1.6288158,1.16823499,3.372541425,0.009213888,0.017698628,"ENSG00000171169","A0A024R887,Chromosome 9 open reading frame 90, isoform CRA_a","NP_931045.1,nuclear apoptosis-inducing factor 1","PF13873,Myb/SANT-like DNA-binding domain","IPR026753,Nuclear apoptosis-inducing factor 1;IPR028002,Myb/SANT-like DNA-binding domain","ENOG410IDY8,-;ENOG4110DBH,-","GO:0005829,cellular_component,cytosol;GO:0006915,biological_process,apoptotic process;GO:0005886,cellular_component,plasma membrane;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["POLD3",7.760135467,3.450341288,1.167893482,4.986906942,{"v":8.81E-5,"d":"8.81E-05"},0.000268589,"ENSG00000077514","A0A024R5M8,Polymerase","NP_006582.1,DNA polymerase delta subunit 3","PF09507,NA polymerase subunit Cdc27","IPR019038,DNA polymerase subunit Cdc27","ENOG410XSD1,-;ENOG410IGGV,-","GO:0006260,biological_process,DNA replication;GO:0006261,biological_process,DNA-dependent DNA replication;GO:0005634,cellular_component,nucleus","K03504,ko03420,Nucleotide excision repair;K03504,ko03440,Homologous recombination;K03504,ko05166,HTLV-I infection;K03504,ko03410,Base excision repair;K03504,ko00230,Purine metabolism;K03504,ko03430,Mismatch repair;K03504,ko00240,Pyrimidine metabolism;K03504,ko03030,DNA replication"]
["TAF8",3.886920319,1.729001595,1.16697389,4.749697273,0.000169126,4.86634E-4,"ENSG00000137413","H2QT00,Uncharacterized protein","XP_518472.2,-","PF07524,Bromodomain associated;PF10406,Transcription factor TFIID complex subunit 8 C-term","IPR037818,Transcription initiation factor TFIID subunit 8;IPR006565,Bromodomain associated domain;IPR009072,Histone-fold;IPR019473,Transcription factor TFIID, subunit 8, C-terminal","KOG4336,TBP-associated transcription factor Prodos;ENOG410ZRN5,-","GO:0046982,molecular_function,protein heterodimerization activity;GO:0005669,cellular_component,transcription factor TFIID complex","-"]
["KIAA0930",2.867818902,1.275464054,1.166778201,4.431007862,0.000462519,1.204225E-3,"ENSG00000100364","K7BH49,KIAA0930","-","PF09741,Uncharacterized conserved protein (DUF2045)","IPR019141,Protein of unknown function DUF2045","-","-","-"]
["CTB-147N14.6",35.93782508,15.99658804,1.166339093,5.033520336,{"v":7.23e-05,"d":"7.23E-05"},0.000226237,"ENSG00000275719","H2QGN5,Amino acid transporter","-","PF00375,Sodium:dicarboxylate symporter family","IPR001991,Sodium:dicarboxylate symporter;IPR018107,Sodium:dicarboxylate symporter, conserved site;IPR036458,Sodium:dicarboxylate symporter superfamily","KOG3787,Glutamate/aspartate and neutral amino acid transporters;COG1301,Na+/H+-dicarboxylate symporters","GO:0055085,biological_process,transmembrane transport;GO:0015293,molecular_function,symporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["C6orf120",5.253149071,2.334310257,1.165771834,3.443734125,0.006572989,0.013103183,"ENSG00000185127","B4DJ79,cDNA FLJ55847","NP_001304271.1,UPF0669 protein C6orf120 isoform 2 precursor","PF17065,Putative cytokine, C6ORF120","IPR031420,UPF0669 protein C6orf120","ENOG41124Y3,-;ENOG410IKRK,-","-","-"]
["PSRC1",24.45298869,10.90298679,1.16440412,5.681661145,{"v":1.3e-05,"d":"1.30E-05"},{"v":4.83e-05,"d":"4.83E-05"},"ENSG00000134222","G3QRB4,Proline and serine rich coiled-coil 1","XP_018866604.1,-;XP_018866509.1,-;XP_018866555.1,-;XP_018866400.1,-;XP_018866665.1,-;XP_018866445.1,-;XP_018866348.1,proline/serine-rich coiled-coil protein 1 isoform X2","PF15259,-2 and S-phase expressed 1","IPR032768,G2 and S phase-expressed protein 1, N-terminal;IPR026658,Proline/serine-rich coiled-coil protein 1;IPR026657,Proline/serine-rich coiled-coil protein 1/G2 and S phase-expressed protein 1","-","GO:0030496,cellular_component,midbody;GO:0007080,biological_process,mitotic metaphase plate congression;GO:0060236,biological_process,regulation of mitotic spindle organization;GO:0009987,biological_process,cellular process;GO:0005737,cellular_component,cytoplasm;GO:0005654,cellular_component,nucleoplasm;GO:0005819,cellular_component,spindle;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0030308,biological_process,negative regulation of cell growth;GO:0000922,cellular_component,spindle pole;GO:0005876,cellular_component,spindle microtubule;GO:0008017,molecular_function,microtubule binding;GO:0005829,cellular_component,cytosol;GO:0001578,biological_process,microtubule bundle formation;GO:0031116,biological_process,positive regulation of microtubule polymerization;GO:0045737,biological_process,positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["SFN",114.0528274,50.88712594,1.163920313,6.777904591,{"v":7.96e-07,"d":"7.96E-07"},{"v":3.84e-06,"d":"3.84E-06"},"ENSG00000175793","G1SAD1,Stratifin","XP_003271711.1,-","PF00244,14-3-3 protein","IPR023410,14-3-3 domain;IPR000308,14-3-3 protein;IPR036815,14-3-3 domain superfamily;IPR037435,14-3-3 protein sigma;IPR023409,14-3-3 protein, conserved site","KOG0841,Multifunctional chaperone (14-3-3 family);COG5040,14-3-3 family protein","GO:0019901,molecular_function,protein kinase binding;GO:0008630,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010839,biological_process,negative regulation of keratinocyte proliferation;GO:0005634,cellular_component,nucleus;GO:0043588,biological_process,skin development;GO:0061436,biological_process,establishment of skin barrier;GO:0031424,biological_process,keratinization;GO:0005737,cellular_component,cytoplasm;GO:0001836,biological_process,release of cytochrome c from mitochondria;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0030307,biological_process,positive regulation of cell growth;GO:0010482,biological_process,regulation of epidermal cell division;GO:0046827,biological_process,positive regulation of protein export from nucleus;GO:0003334,biological_process,keratinocyte development;GO:0000079,biological_process,regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0019904,molecular_function,protein domain specific binding;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045606,biological_process,positive regulation of epidermal cell differentiation;GO:0045296,molecular_function,cadherin binding;GO:0051726,biological_process,regulation of cell cycle;GO:0051219,molecular_function,phosphoprotein binding;GO:0030216,biological_process,keratinocyte differentiation","K06644,ko04960,Aldosterone-regulated sodium reabsorption;K06644,ko04110,Cell cycle;K06644,ko04115,p53 signaling pathway"]
["FAM160A1",2.985103205,1.328724433,1.163550101,3.511548429,0.004725737,0.009748914,"ENSG00000164142","H2QQA0,Uncharacterized protein","XP_016807862.1,-;XP_016807863.1,-;XP_016807864.1,-;XP_526702.4,-;XP_016807861.1,protein FAM160A1","PF10257,Retinoic acid induced 16-like protein","IPR019384,Retinoic acid induced 16-like protein","ENOG410XY4X,-;KOG3695,Uncharacterized conserved protein","-","-"]
["ARRDC1",12.30492247,5.488212637,1.163517008,5.122450491,{"v":6.36e-05,"d":"6.36E-05"},2.01499E-4,"ENSG00000197070","K7BQ27,Arrestin domain containing 1","XP_003312471.2,arrestin domain-containing protein 1 isoform X4","PF00339,Arrestin (or S-antigen), N-terminal domain;PF02752,Arrestin (or S-antigen), C-terminal domain","IPR011022,Arrestin C-terminal-like domain;IPR014752,Arrestin, C-terminal;IPR011021,Arrestin-like, N-terminal;IPR014756,Immunoglobulin E-set","KOG3780,Thioredoxin binding protein TBP-2/VDUP1;ENOG41102NY,-","GO:0031410,cellular_component,cytoplasmic vesicle;GO:0016567,biological_process,protein ubiquitination;GO:1903561,cellular_component,extracellular vesicle;GO:0006858,biological_process,extracellular transport;GO:1990763,molecular_function,arrestin family protein binding;GO:0015031,biological_process,protein transport;GO:0045746,biological_process,negative regulation of Notch signaling pathway;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0140112,biological_process,extracellular vesicle biogenesis;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:1990756,molecular_function,protein binding, bridging involved in substrate recognition for ubiquitination;GO:0005886,cellular_component,plasma membrane;GO:0042802,molecular_function,identical protein binding;GO:0007165,biological_process,signal transduction","-"]
["CUX1",6.020605213,2.689389644,1.162055684,6.291595113,{"v":2.61E-6,"d":"2.61E-06"},{"v":1.13E-5,"d":"1.13E-05"},"ENSG00000257923","H2QV57,Homeobox protein cut-like","-","PF02376,CUT domain;PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR009057,Homeobox-like domain superfamily;IPR003350,CUT domain;IPR010982,Lambda repressor-like, DNA-binding domain superfamily","ENOG410XPKP,-;KOG0963,Transcription factor/CCAAT displacement protein CDP1;KOG2252,CCAAT displacement protein and related homeoproteins","GO:0003677,molecular_function,DNA binding;GO:0048193,biological_process,Golgi vesicle transport;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0050775,biological_process,positive regulation of dendrite morphogenesis;GO:0000139,cellular_component,Golgi membrane;GO:0006351,biological_process,transcription, DNA-templated;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0007275,biological_process,multicellular organism development","-"]
["RBCK1",20.5948287,9.201284616,1.16163346,5.9262737,{"v":6.58e-06,"d":"6.58E-06"},{"v":2.6e-05,"d":"2.60E-05"},"ENSG00000125826","H2QJS6,RanBP-type and C3HC4-type zinc finger containing 1","XP_001152050.1,ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2","PF01485,IBR domain, a half RING-finger domain;PF13445,RING-type zinc-finger","IPR002867,IBR domain;IPR017907,Zinc finger, RING-type, conserved site;IPR001841,Zinc finger, RING-type;IPR036443,Zinc finger, RanBP2-type superfamily;IPR000626,Ubiquitin domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR029071,Ubiquitin-like domain superfamily;IPR027370,RING-type zinc-finger, LisH dimerisation motif;IPR001876,Zinc finger, RanBP2-type;IPR026261,RanBP-type and C3HC4-type zinc finger-containing protein 1","ENOG410XP9Y,-;KOG1815,Predicted E3 ubiquitin ligase","GO:0097039,biological_process,protein linear polyubiquitination;GO:0000209,biological_process,protein polyubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0071797,cellular_component,LUBAC complex;GO:2001238,biological_process,positive regulation of extrinsic apoptotic signaling pathway;GO:0046872,molecular_function,metal ion binding;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0060546,biological_process,negative regulation of necroptotic process;GO:0042346,-,-;GO:0043130,molecular_function,ubiquitin binding;GO:0051092,biological_process,positive regulation of NF-kappaB transcription factor activity;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0050852,biological_process,T cell receptor signaling pathway","-"]
["PRSS22",6.466237722,2.882669605,1.161535955,3.576291703,0.006295613,0.01262496,"ENSG00000005001","H2QAE5,Uncharacterized protein","XP_510756.3,brain-specific serine protease 4;XP_016784696.1,-","PF00089,Trypsin","IPR001254,Serine proteases, trypsin domain;IPR018114,Serine proteases, trypsin family, histidine active site;IPR001314,Peptidase S1A, chymotrypsin family;IPR009003,Peptidase S1, PA clan;IPR033116,Serine proteases, trypsin family, serine active site","KOG3627,Trypsin;COG5640,Secreted trypsin-like serine protease","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0046658,cellular_component,anchored component of plasma membrane;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0008236,molecular_function,serine-type peptidase activity;GO:0019897,cellular_component,extrinsic component of plasma membrane;GO:0008233,molecular_function,peptidase activity","-"]
["TTC19",51.34488559,22.95731144,1.161066464,7.79784753,{"v":1.66E-7,"d":"1.66E-07"},{"v":9.25e-07,"d":"9.25E-07"},"ENSG00000011295","A0A024RD83,Tetratricopeptide repeat domain 19, isoform CRA_a","NP_060245.3,tetratricopeptide repeat protein 19, mitochondrial isoform 1 precursor","PF13374,Tetratricopeptide repeat;PF13424,Tetratricopeptide repeat","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","KOG1840,Kinesin light chain;COG0457,FOG: TPR repeat","GO:0005739,cellular_component,mitochondrion","-"]
["TRMT13",3.906917464,1.744155769,1.159701597,3.638231121,0.004597086,0.00953608,"ENSG00000122435","H2PZH2,Coiled-coil domain containing 76","XP_001160498.1,m(4)X modification enzyme TRM13 homolog isoform X1","PF11722,CCCH zinc finger in TRM13 protein;PF05253,U11-48K-like CHHC zinc finger;PF05206,Methyltransferase TRM13","IPR021721,Zinc finger, CCCH-type, TRM13;IPR022776,TRM13/UPF0224 family, U11-48K-like CHHC zinc finger domain;IPR007871,Methyltransferase TRM13","ENOG410Z6H8,-;KOG2811,Uncharacterized conserved protein","GO:0008033,biological_process,tRNA processing;GO:0030488,biological_process,tRNA methylation;GO:0008175,molecular_function,tRNA methyltransferase activity;GO:0008168,molecular_function,methyltransferase activity","-"]
["SMIM5",1.438589897,0.640342867,1.159392861,2.591538747,0.03830181,0.062312074,"ENSG00000204323","H9EW15,Uncharacterized protein C17orf109","XP_014975876.1,-;XP_001099113.1,small integral membrane protein 5 isoform X3","PF15831,omain of unknown function (DUF4713)","IPR031671,Protein of unknown function DUF4713","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RP11-805J14.5",69.52344511,31.11344286,1.159090044,5.692869329,{"v":1.29E-5,"d":"1.29E-05"},{"v":4.78e-05,"d":"4.78E-05"},"ENSG00000254721","Q6LCB0,FADD protein","-","PF00531,eath domain","IPR001875,Death effector domain;IPR011029,Death-like domain superfamily;IPR000488,Death domain","ENOG41122TX,-;ENOG410J0KM,-","GO:0042981,biological_process,regulation of apoptotic process;GO:0007165,biological_process,signal transduction","-"]
["TRAFD1",8.919822716,3.991838925,1.158219937,4.714854326,0.000241595,0.000672662,"ENSG00000135148","A0A024RBK4,TRAF-type zinc finger domain containing 1, isoform CRA_a","NP_001137378.1,-;NP_006691.1,TRAF-type zinc finger domain-containing protein 1","-","IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG4111IF3,-;ENOG410IGBJ,-","GO:0045824,biological_process,negative regulation of innate immune response","-"]
["BCORL1",2.108513046,0.942503656,1.158023983,3.697600388,0.004223812,0.00884615,"ENSG00000085185","F7F6C2,BCL6 corepressor like 1","-","PF12796,Ankyrin repeats (3 copies);PF16553,BCORL-PCGF1-binding domain","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR032365,BCL-6 corepressor, PCGF1 binding domain;IPR038227,PCGF Ub-like fold discriminator superfamily;IPR036770,Ankyrin repeat-containing domain superfamily","-","GO:0005886,cellular_component,plasma membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["CERK",5.337803995,2.388797899,1.15764063,4.313599925,0.000776147,1.920143E-3,"ENSG00000100422","A0A024R4U8,Ceramide kinase, isoform CRA_b","NP_073603.2,ceramide kinase","PF00781,iacylglycerol kinase catalytic domain","IPR017438,Inorganic polyphosphate/ATP-NAD kinase, N-terminal;IPR001206,Diacylglycerol kinase, catalytic domain;IPR016064,NAD kinase/diacylglycerol kinase-like domain superfamily","KOG1115,Ceramide kinase;COG1597,Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase","GO:0016301,molecular_function,kinase activity;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0001729,molecular_function,ceramide kinase activity;GO:0046834,biological_process,lipid phosphorylation;GO:0016310,biological_process,phosphorylation;GO:0003951,molecular_function,NAD+ kinase activity","K04715,ko00600,Sphingolipid metabolism"]
["CEP350",9.763412728,4.376177751,1.157276538,6.672122602,{"v":1.19E-6,"d":"1.19E-06"},{"v":5.55e-06,"d":"5.55E-06"},"ENSG00000135837","A0A024R914,Centrosomal protein 350kDa, isoform CRA_a","-","PF01302,CAP-Gly domain","IPR000938,CAP Gly-rich domain;IPR036859,CAP Gly-rich domain superfamily;IPR028750,Centrosome-associated protein 350","ENOG410YQD7,-;ENOG410ISTJ,-","GO:0005813,cellular_component,centrosome;GO:0034453,biological_process,microtubule anchoring;GO:0008017,molecular_function,microtubule binding","-"]
["ICE2",1.690846756,0.757248436,1.15665035,4.350950648,0.000734829,0.001828207,"ENSG00000128915","A0A024R5V9,NMDA receptor regulated 2, isoform CRA_b","XP_016878058.1,-;XP_005254718.1,-;XP_011520311.1,-;NP_078887.2,little elongation complex subunit 2 isoform a","PF10505,NMDA receptor-regulated gene protein 2 C-terminus","IPR019535,Little elongation complex subunit 2 , C-terminal","ENOG410IEUC,-;ENOG410Y4F7,-","GO:0005829,cellular_component,cytosol;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0008023,cellular_component,transcription elongation factor complex;GO:0005654,cellular_component,nucleoplasm","-"]
["RP11-22B23.1",2.556569012,1.141322956,1.155927361,2.712559006,0.033509944,0.055389793,"ENSG00000111788","F6WMZ3,DEAD/H-box helicase 11","-","PF13307,Helicase C-terminal domain;PF06733,AD_2","IPR028331,Probable ATP-dependent RNA helicase DDX11/DDX12;IPR013020,ATP-dependent helicase Rad3/Chl1-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR006554,Helicase-like, DEXD box c2 type;IPR014013,Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type;IPR010614,DEAD2;IPR006555,ATP-dependent helicase, C-terminal","COG1199,Rad3-related DNA helicases;KOG1133,Helicase of the DEAD superfamily","GO:0004386,molecular_function,helicase activity;GO:0003677,molecular_function,DNA binding;GO:0016787,molecular_function,hydrolase activity;GO:0016818,molecular_function,hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0005634,cellular_component,nucleus;GO:0008026,molecular_function,ATP-dependent helicase activity;GO:0003676,molecular_function,nucleic acid binding;GO:0032508,biological_process,DNA duplex unwinding;GO:0006139,biological_process,nucleobase-containing compound metabolic process;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004003,molecular_function,ATP-dependent DNA helicase activity","-"]
["USP32P1",1.051803666,0.469554181,1.155927361,2.712559006,0.033509944,0.055389793,"ENSG00000188933","K7EQL6,Ubiquitin carboxyl-terminal hydrolase 32","-","PF14836,Ubiquitin-like domain;PF06337,USP domain;PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase;IPR028889,Ubiquitin specific protease domain;IPR035927,DUSP-like superfamily;IPR006615,Peptidase C19, ubiquitin-specific peptidase, DUSP domain;IPR028135,Ubiquitin-like domain, USP-type","COG5560,Ubiquitin C-terminal hydrolase;KOG1870,Ubiquitin C-terminal hydrolase;KOG0044,Ca2+ sensor (EF-Hand superfamily)","GO:0005794,cellular_component,Golgi apparatus;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0004843,molecular_function,thiol-dependent ubiquitin-specific protease activity;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0005829,cellular_component,cytosol;GO:0016579,biological_process,protein deubiquitination","-"]
["CISD2",10.65701458,4.776068628,1.155711419,4.387354682,0.000581778,0.001483059,"ENSG00000145354","D6RCF4,CDGSH iron-sulfur domain-containing protein 2","-","PF10660,Iron-containing outer mitochondrial membrane protein N-terminus;PF09360,Iron-binding zinc finger CDGSH type","IPR019610,Iron sulphur domain-containing, mitoNEET, N-terminal;IPR018967,Iron sulphur-containing domain, CDGSH-type","KOG3461,CDGSH-type Zn-finger containing protein;ENOG41122II,-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005783,cellular_component,endoplasmic reticulum;GO:0051537,molecular_function,2 iron, 2 sulfur cluster binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CTSD",44.81813363,20.125202,1.15464459,6.677780334,{"v":1.19E-6,"d":"1.19E-06"},{"v":5.55e-06,"d":"5.55E-06"},"ENSG00000117984","V9HWI3,Cathepsin D","NP_001900.1,cathepsin D preproprotein","PF00026,ukaryotic aspartyl protease;PF07966,A1 Propeptide","IPR012848,Aspartic peptidase, N-terminal;IPR033121,Peptidase family A1 domain;IPR001461,Aspartic peptidase A1 family;IPR021109,Aspartic peptidase domain superfamily;IPR001969,Aspartic peptidase, active site;IPR033144,Cathepsin D","KOG1339,Aspartyl protease;ENOG410XNV7,-","GO:0004190,molecular_function,aspartic-type endopeptidase activity;GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0005764,cellular_component,lysosome;GO:0008233,molecular_function,peptidase activity","K01379,ko04210,Apoptosis;K01379,ko05152,Tuberculosis;K01379,ko04142,Lysosome;K01379,ko04071,Sphingolipid signaling pathway"]
["2020-03-06",7.918131168,3.55527556,1.154520104,6.042068614,{"v":5.58e-06,"d":"5.58E-06"},{"v":2.24e-05,"d":"2.24E-05"},"ENSG00000145495","H2QQM9,Membrane-associated ring finger","XP_003310676.1,-","PF12906,RING-variant domain","IPR011016,Zinc finger, RING-CH-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG1609,Protein involved in mRNA turnover and stability;COG5183,Protein involved in mRNA turnover and stability","GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0046872,molecular_function,metal ion binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:1904264,-,-;GO:0008270,molecular_function,zinc ion binding","K10661,ko04141,Protein processing in endoplasmic reticulum"]
["LMO7",34.82484347,15.64537644,1.15425884,8.50557286,{"v":9.43e-08,"d":"9.43E-08"},{"v":5.56e-07,"d":"5.56E-07"},"ENSG00000136153","J3KP06,LIM domain only protein 7","-","PF00412,LIM domain;PF00595,PDZ domain (Also known as DHR or GLGF);PF00307,Calponin homology (CH) domain;PF15949,omain of unknown function (DUF4757)","IPR001715,Calponin homology domain;IPR029978,LIM domain only protein 7;IPR036872,CH domain superfamily;IPR001478,PDZ domain;IPR003096,Smooth muscle protein/calponin;IPR031865,Domain of unknown function DUF4757;IPR001781,Zinc finger, LIM-type;IPR036034,PDZ superfamily","KOG1704,FOG: LIM domain;ENOG410XP0W,-","GO:0023051,biological_process,regulation of signaling;GO:0030155,biological_process,regulation of cell adhesion;GO:0046872,molecular_function,metal ion binding","-"]
["IRF6",22.99715751,10.33323174,1.153625863,6.371167243,{"v":2.38e-06,"d":"2.38E-06"},{"v":1.04E-5,"d":"1.04E-05"},"ENSG00000117595","G1QN90,Interferon regulatory factor 6","-","PF00605,Interferon regulatory factor transcription factor;PF10401,Interferon-regulatory factor 3","IPR019817,Interferon regulatory factor, conserved site;IPR017855,SMAD-like domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR019471,Interferon regulatory factor-3;IPR008984,SMAD/FHA domain superfamily;IPR036390,Winged helix DNA-binding domain superfamily;IPR001346,Interferon regulatory factor DNA-binding domain","ENOG410XRXT,-;ENOG410IFCV,-","GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["NAT10",15.8548361,7.125836081,1.153060337,5.932916383,{"v":7.18e-06,"d":"7.18E-06"},{"v":2.82e-05,"d":"2.82E-05"},"ENSG00000135372","K7C0Y4,RNA cytidine acetyltransferase","XP_016776146.1,RNA cytidine acetyltransferase;XP_016776148.1,-;XP_016776147.1,-","PF08351,omain of unknown function (DUF1726);PF13725,Possible tRNA binding domain;PF13718,NAT acetyltransferase 2;PF05127,Helicase","IPR032672,TmcA/NAT10/Kre33;IPR000182,GNAT domain;IPR033688,RNA cytidine acetyltransferase NAT10;IPR027992,Possible tRNA binding domain;IPR007807,Helicase domain;IPR013562,tRNA(Met) cytidine acetyltransferase TmcA, N-terminal;IPR016181,Acyl-CoA N-acyltransferase","KOG2036,Predicted P-loop ATPase fused to an acetyltransferase;COG1444,Predicted P-loop ATPase fused to an acetyltransferase","GO:0042274,biological_process,ribosomal small subunit biogenesis;GO:0016072,biological_process,rRNA metabolic process;GO:0008033,biological_process,tRNA processing;GO:0005730,cellular_component,nucleolus;GO:0000154,biological_process,rRNA modification;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0008080,molecular_function,N-acetyltransferase activity;GO:0051391,biological_process,tRNA acetylation;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0006364,biological_process,rRNA processing;GO:0034470,biological_process,ncRNA processing","K14521,ko03008,Ribosome biogenesis in eukaryotes"]
["NHLRC3",1.370888653,0.613506216,1.153028044,2.824085292,0.033996142,0.055923533,"ENSG00000188811","H2Q7G1,NHL repeat containing 3","XP_509638.2,-","PF01436,NHL repeat","IPR011042,Six-bladed beta-propeller, TolB-like;IPR001258,NHL repeat;IPR013017,NHL repeat, subgroup","ENOG410ITFF,-;ENOG410ZCFR,-","-","-"]
["MED7",3.01614328,1.34979792,1.153028044,2.824085292,0.033996142,0.055923533,"ENSG00000155868","H2QRW1,Mediator of RNA polymerase II transcription subunit 7","XP_016809604.1,-;XP_003310988.1,-;XP_016809603.1,-;XP_009448322.1,-","PF05983,MED7 protein","IPR009244,Mediator complex, subunit Med7;IPR037212,Mediator complex, subunit Med7/Med21-like","KOG0570,Transcriptional coactivator;ENOG410ZFRU,-","GO:0019827,biological_process,stem cell population maintenance;GO:0005667,cellular_component,transcription factor complex;GO:0016592,cellular_component,mediator complex;GO:0003713,molecular_function,transcription coactivator activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus","-"]
["NGDN",4.234893008,1.900926733,1.152537786,3.91315204,0.002305017,0.005150603,"ENSG00000129460","H2R2X6,Neuroguidin, EIF4E binding protein","XP_001163084.1,neuroguidin","PF04000,Sas10/Utp3/C1D family","IPR007146,Sas10/Utp3/C1D","KOG3117,Protein involved in rRNA processing;ENOG4111F0Z,-","GO:0032040,cellular_component,small-subunit processome;GO:0005739,cellular_component,mitochondrion;GO:0000462,biological_process,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus","-"]
["HOXA10",5.316749948,2.386542492,1.152537786,3.91315204,0.002305017,0.005150603,"ENSG00000253293","F6YAI9,Homeobox A10","XP_014989316.1,homeobox protein Hox-A10","PF00046,Homeobox domain","IPR017987,Wilm's tumour protein;IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR020479,Homeobox domain, metazoa;IPR009057,Homeobox-like domain superfamily","KOG0487,Transcription factor Abd-B, contains HOX domain;ENOG4111FJP,-","GO:0007283,biological_process,spermatogenesis;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0042826,molecular_function,histone deacetylase binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0001501,biological_process,skeletal system development;GO:0007338,biological_process,single fertilization;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0007275,biological_process,multicellular organism development;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0008584,biological_process,male gonad development;GO:0005737,cellular_component,cytoplasm;GO:0010468,biological_process,regulation of gene expression;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0009954,biological_process,proximal/distal pattern formation;GO:0060065,biological_process,uterus development;GO:0005634,cellular_component,nucleus","-"]
["CTNND1",30.79586562,13.85437617,1.152170856,7.624233689,{"v":2.59e-07,"d":"2.59E-07"},{"v":1.38e-06,"d":"1.38E-06"},"ENSG00000198561","G3RGV2,Catenin delta 1","XP_004051239.2,catenin delta-1 isoform X6","PF00514,Armadillo/beta-catenin-like repeat","IPR000225,Armadillo;IPR016024,Armadillo-type fold;IPR011989,Armadillo-like helical;IPR028435,Plakophilin/Delta catenin;IPR028439,Catenin delta-1","-","GO:0098609,biological_process,cell-cell adhesion;GO:0045296,molecular_function,cadherin binding","-"]
["N4BP1",3.998563487,1.797362947,1.151663246,4.556704289,0.000366398,0.000978338,"ENSG00000102921","H2QB24,NEDD4 binding protein 1","XP_520627.3,NEDD4-binding protein 1 isoform X1","PF11977,Zc3h12a-like Ribonuclease NYN domain","IPR021869,Ribonuclease Zc3h12a-like, NYN domain","KOG3777,Uncharacterized conserved protein;ENOG410ZNK1,-","GO:0016605,cellular_component,PML body;GO:0031397,biological_process,negative regulation of protein ubiquitination;GO:0034644,biological_process,cellular response to UV;GO:0005730,cellular_component,nucleolus;GO:0032435,biological_process,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0005634,cellular_component,nucleus","-"]
["CDCA7",8.148734015,3.664766544,1.150962601,4.588304933,0.000350466,0.000940008,"ENSG00000144354","H2P7V0,Cell division cycle associated 7","XP_002812639.1,cell division cycle-associated protein 7 isoform X1","PF10497,Zinc-finger domain of monoamine-oxidase A repressor R1","IPR033576,Cell division cycle-associated protein 7;IPR018866,Zinc-finger domain of monoamine-oxidase A repressor R1","ENOG410ZWEA,-;ENOG410IFJD,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0042127,biological_process,regulation of cell proliferation;GO:0005654,cellular_component,nucleoplasm","-"]
["ZNF407",0.779196539,0.349435996,1.150566632,2.927504331,0.02294735,0.039785791,"ENSG00000215421","K7DAA4,Zinc finger protein 407","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR003604,Matrin/U1-C-like, C2H2-type zinc finger;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding","-"]
["KRAS",10.76407944,4.846295819,1.15049964,5.854271157,{"v":9.17e-06,"d":"9.17E-06"},{"v":3.52e-05,"d":"3.52E-05"},"ENSG00000133703","G5BQA1,GTPase KRas","XP_012928012.1,-;XP_012928011.1,-","PF00071,Ras family","IPR020849,Small GTPase superfamily, Ras type;IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0010628,biological_process,positive regulation of gene expression;GO:0005737,cellular_component,cytoplasm;GO:0005525,molecular_function,GTP binding;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0031647,biological_process,regulation of protein stability;GO:0031234,cellular_component,extrinsic component of cytoplasmic side of plasma membrane;GO:0000166,molecular_function,nucleotide binding;GO:0007165,biological_process,signal transduction;GO:0001934,biological_process,positive regulation of protein phosphorylation","-"]
["ATG13",4.68068848,2.106106989,1.150292705,4.619225877,0.000284097,0.000778474,"ENSG00000175224","G3QSD9,Autophagy-related protein 13","XP_018892117.1,-;XP_018892116.1,-;XP_018892120.1,-;XP_018892118.1,-;XP_018892119.1,-;XP_004051071.1,autophagy-related protein 13 isoform X1;XP_018892121.1,-","PF10033,Autophagy-related protein 13","IPR036570,HORMA domain superfamily;IPR018731,Autophagy-related protein 13","-","GO:0006914,biological_process,autophagy;GO:1990316,cellular_component,Atg1/ULK1 kinase complex","-"]
["PTPN11",28.39234173,12.7946108,1.149661807,7.183703127,{"v":4.95e-07,"d":"4.95E-07"},{"v":2.5e-06,"d":"2.50E-06"},"ENSG00000179295","K7CNV8,Tyrosine-protein phosphatase non-receptor type","-","PF00102,Protein-tyrosine phosphatase;PF00017,SH2 domain","IPR029021,Protein-tyrosine phosphatase-like;IPR036860,SH2 domain superfamily;IPR000242,PTP type protein phosphatase;IPR016130,Protein-tyrosine phosphatase, active site;IPR000980,SH2 domain;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR000387,Tyrosine specific protein phosphatases domain;IPR012152,Protein-tyrosine phosphatase, non-receptor type-6, -11","COG5599,Protein tyrosine phosphatase;KOG0790,Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","-"]
["NPEPL1",2.859093491,1.286468179,1.149370386,4.055893195,1.525062E-3,0.003534392,"ENSG00000215440","K7B388,Aminopeptidase-like 1","XP_016793667.1,probable aminopeptidase NPEPL1 isoform X2","PF00883,Cytosol aminopeptidase family, catalytic domain","IPR000819,Peptidase M17, leucyl aminopeptidase, C-terminal;IPR011356,Peptidase M17, leucine aminopeptidase/peptidase B","KOG2597,Predicted aminopeptidase of the M17 family;COG0260,Leucyl aminopeptidase","GO:0006508,biological_process,proteolysis;GO:0008235,molecular_function,metalloexopeptidase activity;GO:0005737,cellular_component,cytoplasm;GO:0004177,molecular_function,aminopeptidase activity;GO:0019538,biological_process,protein metabolic process;GO:0005622,cellular_component,intracellular;GO:0030145,molecular_function,manganese ion binding","-"]
["PYCR2",19.77735802,8.914774464,1.148730793,5.715028909,{"v":1.4E-5,"d":"1.40E-05"},{"v":5.15e-05,"d":"5.15E-05"},"ENSG00000143811","A0A0S2Z5U6,Pyrroline-5-carboxylate reductase","NP_037460.2,pyrroline-5-carboxylate reductase 2 isoform 1","PF03807,NADP oxidoreductase coenzyme F420-dependent;PF14748,Pyrroline-5-carboxylate reductase dimerisation","IPR036291,NAD(P)-binding domain superfamily;IPR028939,Pyrroline-5-carboxylate reductase, catalytic, N-terminal;IPR029036,Pyrroline-5-carboxylate reductase, dimerisation domain;IPR008927,6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily;IPR000304,Pyrroline-5-carboxylate reductase","-","GO:0008652,biological_process,cellular amino acid biosynthetic process;GO:0055129,biological_process,L-proline biosynthetic process;GO:0004735,molecular_function,pyrroline-5-carboxylate reductase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0005739,cellular_component,mitochondrion;GO:0055114,biological_process,oxidation-reduction process;GO:0006561,biological_process,proline biosynthetic process","K00286,ko01230,Biosynthesis of amino acids;K00286,ko00330,Arginine and proline metabolism"]
["KLF16",3.455426818,1.552381804,1.148450877,3.023919443,0.020364993,0.035751482,"ENSG00000129911","A0A0D9RHL7,Kruppel like factor 16","XP_007992853.1,Krueppel-like factor 16","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003677,molecular_function,DNA binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0007212,biological_process,dopamine receptor signaling pathway;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding","-"]
["SMIM14",3.356451987,1.51131778,1.148449054,4.100481679,1.628993E-3,3.754173E-3,"ENSG00000163683","A0A024R9S4,Uncharacterized protein","NP_001304825.1,-;XP_016863351.1,-;XP_016863352.1,-;NP_777581.1,small integral membrane protein 14;NP_001304826.1,-","PF11027,Protein of unknown function (DUF2615)","IPR020309,Uncharacterised protein family, CD034/YQF4","ENOG410J29M,-;ENOG41127PU,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RIMKLB",4.04996419,1.824787721,1.148448519,4.708188661,2.83396E-4,7.77171E-4,"ENSG00000166532","G3QDK5,Ribosomal modification protein rimK like family member B","XP_018894746.1,-;XP_004052708.2,-;XP_018894745.1,-","PF08443,RimK-like ATP-grasp domain","IPR004666,Ribosomal S6 modification enzyme RimK/Lysine biosynthesis enzyme LysX;IPR013651,ATP-grasp fold, RimK-type;IPR013815,ATP-grasp fold, subdomain 1;IPR011761,ATP-grasp fold","-","GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0046872,molecular_function,metal ion binding;GO:0006464,biological_process,cellular protein modification process","-"]
["ZRANB2",22.6854575,10.23743189,1.147381084,6.376058064,{"v":2.95e-06,"d":"2.95E-06"},{"v":1.26E-5,"d":"1.26E-05"},"ENSG00000132485","A0A287D4Z7,Zinc finger Ran-binding domain-containing protein 2","XP_005332396.1,zinc finger Ran-binding domain-containing protein 2 isoform X1","-","IPR017337,Uncharacterised conserved protein UCP037956, zinc finger Ran-binding;IPR001876,Zinc finger, RanBP2-type;IPR036443,Zinc finger, RanBP2-type superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding","-"]
["EPHX1",9.562788945,4.311361119,1.146771862,4.185704891,0.001181787,2.812555E-3,"ENSG00000143819","R4SBI6,Epoxide hydrolase","NP_000111.1,epoxide hydrolase 1;NP_001129490.1,-;NP_001278092.1,-","PF00561,alpha/beta hydrolase fold;PF06441,poxide hydrolase N terminus","IPR016292,Epoxide hydrolase;IPR000639,Epoxide hydrolase-like;IPR010497,Epoxide hydrolase, N-terminal;IPR029058,Alpha/Beta hydrolase fold","KOG2565,Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily);COG0596,Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)","GO:0016787,molecular_function,hydrolase activity;GO:0014070,biological_process,response to organic cyclic compound;GO:0003824,molecular_function,catalytic activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0019439,biological_process,aromatic compound catabolic process;GO:0033961,molecular_function,cis-stilbene-oxide hydrolase activity;GO:0016020,cellular_component,membrane;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0006725,biological_process,cellular aromatic compound metabolic process","K01253,ko04976,Bile secretion;K01253,ko05204,Chemical carcinogenesis;K01253,ko00980,Metabolism of xenobiotics by cytochrome P450"]
["SLC9A7",1.088723879,0.489878568,1.146612744,3.114222848,0.013999645,0.025768762,"ENSG00000065923","A0A087WXD1,Sodium/hydrogen exchanger","XP_005272738.1,-;XP_005272739.1,-;XP_011542292.1,-;NP_001244220.1,sodium/hydrogen exchanger 7 isoform 1 precursor;XP_016885394.1,-","PF00999,Sodium/hydrogen exchanger family","IPR004709,Na+/H+ exchanger;IPR018422,Cation/H+ exchanger, CPA1 family;IPR006153,Cation/H+ exchanger;IPR002090,Na+/H+ exchanger, isoform 6 (NHE6)","COG0025,NhaP-type Na+/H+ and K+/H+ antiporters;KOG1965,Sodium/hydrogen exchanger protein","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0006814,biological_process,sodium ion transport;GO:1902600,biological_process,proton transmembrane transport;GO:0015299,molecular_function,solute:proton antiporter activity;GO:0006811,biological_process,ion transport;GO:0006812,biological_process,cation transport;GO:0055085,biological_process,transmembrane transport;GO:0015297,molecular_function,antiporter activity;GO:0035725,biological_process,sodium ion transmembrane transport;GO:0016020,cellular_component,membrane;GO:0006885,biological_process,regulation of pH;GO:0015385,molecular_function,sodium:proton antiporter activity;GO:0016021,cellular_component,integral component of membrane","-"]
["LSG1",10.69507089,4.828581279,1.146105191,5.256920796,{"v":5.27E-5,"d":"5.27E-05"},1.70073E-4,"ENSG00000041802","H2R7V1,Large subunit GTPase 1 homolog","-","PF01926,50S ribosome-binding GTPase","IPR030378,Circularly permuted (CP)-type guanine nucleotide-binding (G) domain;IPR006073,GTP binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1161,Predicted GTPases;KOG1424,Predicted GTP-binding protein MMR1","GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity;GO:0042254,biological_process,ribosome biogenesis;GO:0005829,cellular_component,cytosol","K14539,ko03008,Ribosome biogenesis in eukaryotes"]
["TRMT12",16.50302168,7.450091201,1.145833867,4.845226638,0.00019271,0.000550007,"ENSG00000183665","G3QYA9,tRNA methyltransferase 12 homolog","-","PF02475,Met-10+ like-protein","-","-","-","-"]
["TXLNA",37.78515343,17.07985036,1.14521203,7.138157887,{"v":6.13E-7,"d":"6.13E-07"},{"v":3.03e-06,"d":"3.03E-06"},"ENSG00000084652","G3QGT7,Taxilin alpha","XP_018869972.1,-;XP_004025403.1,alpha-taxilin isoform X1","PF09728,Myosin-like coiled-coil protein","IPR026183,Taxilin family","-","GO:0019905,molecular_function,syntaxin binding","-"]
["DTD2",3.916373988,1.764596136,1.145000953,3.199146293,0.018538748,0.032752671,"ENSG00000129480","G3RAW7,Uncharacterized protein","-","PF02580,-Tyr-tRNA(Tyr) deacylase","-","-","-","-"]
["BRF1",1.983794029,0.895867246,1.144601582,4.304742276,0.000932066,0.002261039,"ENSG00000185024","K7AAU2,BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB","XP_016782328.1,-","PF00382,Transcription factor TFIIB repeat;PF07741,Brf1-like TBP-binding domain;PF08271,TFIIB zinc-binding","IPR013150,Transcription factor TFIIB, cyclin-like domain;IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR011665,Brf1, TBP-binding domain;IPR013137,Zinc finger, TFIIB-type;IPR000812,Transcription factor TFIIB;IPR029529,Transcription factor IIIB subunit Brf1","COG1405,Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB;KOG1598,Transcription initiation factor TFIIIB, Brf1 subunit","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001026,molecular_function,TFIIIB-type transcription factor activity;GO:0003743,molecular_function,translation initiation factor activity;GO:0000126,cellular_component,transcription factor TFIIIB complex;GO:0046872,molecular_function,metal ion binding;GO:0006413,biological_process,translational initiation;GO:0006359,biological_process,regulation of transcription by RNA polymerase III;GO:0017025,molecular_function,TBP-class protein binding;GO:0070897,biological_process,DNA-templated transcriptional preinitiation complex assembly;GO:0006383,biological_process,transcription by RNA polymerase III","-"]
["GRPEL1",13.18907199,5.961795984,1.144432522,5.351915468,{"v":4.09e-05,"d":"4.09E-05"},1.35582E-4,"ENSG00000109519","G3RJT9,GrpE protein homolog","XP_004038457.1,-","PF01025,rpE","IPR013805,GrpE nucleotide exchange factor, coiled-coil;IPR009012,GrpE nucleotide exchange factor, head;IPR000740,GrpE nucleotide exchange factor","-","GO:0051087,molecular_function,chaperone binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0006457,biological_process,protein folding;GO:0050790,biological_process,regulation of catalytic activity;GO:0005739,cellular_component,mitochondrion;GO:0005759,cellular_component,mitochondrial matrix;GO:0000774,molecular_function,adenyl-nucleotide exchange factor activity;GO:0005634,cellular_component,nucleus;GO:0051082,molecular_function,unfolded protein binding","-"]
["PHF23",25.25627129,11.42053689,1.14415596,5.69733632,{"v":1.57e-05,"d":"1.57E-05"},{"v":5.71e-05,"d":"5.71E-05"},"ENSG00000040633","H2QC25,PHD finger protein 23","XP_001169367.1,PHD finger protein 23 isoform X2","PF00628,PHD-finger","IPR001965,Zinc finger, PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR019787,Zinc finger, PHD-finger","ENOG4111YY1,-;ENOG410IMXF,-","GO:1902902,biological_process,negative regulation of autophagosome assembly;GO:0007076,biological_process,mitotic chromosome condensation;GO:0046872,molecular_function,metal ion binding;GO:0031398,biological_process,positive regulation of protein ubiquitination;GO:1901097,biological_process,negative regulation of autophagosome maturation;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","-"]
["ZDHHC23",1.72988618,0.780369651,1.143576121,3.279297369,0.013018034,0.024146982,"ENSG00000184307","E9PAP7,Palmitoyltransferase","XP_016861574.1,-;XP_011510921.1,palmitoyltransferase ZDHHC23 isoform X4","PF01529,HHC palmitoyltransferase","IPR001594,Palmitoyltransferase, DHHC domain","KOG1311,DHHC-type Zn-finger proteins;COG5273,Uncharacterized protein containing DHHC-type Zn finger","GO:0016020,cellular_component,membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016740,molecular_function,transferase activity;GO:0016021,cellular_component,integral component of membrane;GO:0019706,molecular_function,protein-cysteine S-palmitoyltransferase activity","-"]
["PNPLA8",2.178533443,0.982759098,1.143576121,3.279297369,0.013018034,0.024146982,"ENSG00000135241","A0A024R746,Intracellular membrane-associated calcium-independent phospholipase A2 gamma, isoform CRA_a","NP_001242937.1,-;NP_001242936.1,-;NP_056538.1,calcium-independent phospholipase A2-gamma isoform 1","PF01734,Patatin-like phospholipase","IPR002641,Patatin-like phospholipase domain;IPR016035,Acyl transferase/acyl hydrolase/lysophospholipase","KOG4231,Intracellular membrane-bound Ca2+-independent phospholipase A2;ENOG410XQXJ,-","GO:0006629,biological_process,lipid metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0016042,biological_process,lipid catabolic process;GO:0008152,biological_process,metabolic process","-"]
["ACOX1",3.251342877,1.469689673,1.143343084,4.37894878,0.000696347,0.001742818,"ENSG00000161533","A0A024R8T3,Acyl-coenzyme A oxidase","-","PF14749,Acyl-coenzyme A oxidase N-terminal;PF02770,Acyl-CoA dehydrogenase, middle domain;PF01756,Acyl-CoA oxidase","IPR036250,Acyl-CoA dehydrogenase-like, C-terminal;IPR034171,Peroxisomal acyl-coenzyme A oxidase;IPR029320,Acyl-coenzyme A oxidase, N-terminal;IPR009100,Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily;IPR037069,Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily;IPR002655,Acyl-CoA oxidase, C-terminal;IPR006091,Acyl-CoA oxidase/dehydrogenase, central domain;IPR012258,Acyl-CoA oxidase","COG1960,Acyl-CoA dehydrogenases;KOG0136,Acyl-CoA oxidase","GO:0006631,biological_process,fatty acid metabolic process;GO:0006635,biological_process,fatty acid beta-oxidation;GO:0016627,molecular_function,oxidoreductase activity, acting on the CH-CH group of donors;GO:0005777,cellular_component,peroxisome;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0071949,molecular_function,FAD binding;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0003997,molecular_function,acyl-CoA oxidase activity","-"]
["N4BP2",1.327941839,0.599689071,1.142307502,3.355186098,0.009213888,0.017698628,"ENSG00000078177","K7DTK3,NEDD4 binding protein 2","XP_009445800.2,-;XP_009445799.2,-;XP_526557.3,NEDD4-binding protein 2 isoform X1","PF01713,Smr domain;PF13671,AAA domain;PF08590,omain of unknown function (DUF1771)","IPR036063,Smr domain superfamily;IPR009060,UBA-like superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR002625,Smr domain;IPR003892,Ubiquitin system component Cue;IPR013899,Domain of unknown function DUF1771","KOG2401,Predicted MutS-related protein involved in mismatch repair;ENOG41101K4,-","GO:0046404,molecular_function,ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524,molecular_function,ATP binding;GO:0005829,cellular_component,cytosol;GO:0016310,biological_process,phosphorylation;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0004519,molecular_function,endonuclease activity","-"]
["SGSM2",3.110725473,1.408439739,1.141182203,4.516765562,0.000539089,1.387646E-3,"ENSG00000141258","K7C3D2,Small G protein signaling modulator 2","-","PF00566,Rab-GTPase-TBC domain;PF02759,RUN domain","IPR000195,Rab-GTPase-TBC domain;IPR035969,Rab-GTPase-TBC domain superfamily;IPR037213,RUN domain superfamily;IPR037745,Small G protein signaling modulator 1/2, PH domain;IPR004012,RUN domain","KOG1648,Uncharacterized conserved protein, contains RUN, BRK and TBC domains;COG5210,GTPase-activating protein","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005096,molecular_function,GTPase activator activity","-"]
["INTS9",2.807887549,1.2692365859999999,1.141170739,3.42724477,0.008349485,0.016228051,"ENSG00000104299","H2QVZ2,Integrator complex subunit 9","-","PF16661,Metallo-beta-lactamase superfamily domain;PF10996,Beta-Casp domain","IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR027074,Integrator complex subunit 9;IPR001279,Metallo-beta-lactamase;IPR022712,Beta-Casp domain","KOG1138,Predicted cleavage and polyadenylation specificity factor (CPSF subunit);COG1236,Predicted exonuclease of the beta-lactamase fold involved in RNA processing","GO:0032039,cellular_component,integrator complex;GO:0016180,biological_process,snRNA processing","-"]
["ERC1",7.502078159,3.40202331,1.140305971,6.216797538,{"v":4.63e-06,"d":"4.63E-06"},{"v":1.9e-05,"d":"1.90E-05"},"ENSG00000082805","X6RLX0,ELKS/Rab6-interacting/CAST family member 1","XP_016874551.1,ELKS/Rab6-interacting/CAST family member 1 isoform X6","PF10174,RIM-binding protein of the cytomatrix active zone;PF09457,IP domain","IPR019323,Active zone protein ELKS;IPR019018,Rab-binding domain FIP-RBD;IPR037245,FIP-RBD, C-terminal domain superfamily","ENOG410Y4GU,-;KOG4809,Rab6 GTPase-interacting protein involved in endosome-to-TGN transport","GO:0048786,cellular_component,presynaptic active zone","-"]
["CHKA",3.73615395,1.690293758,1.140146293,3.495842984,0.005993278,0.012077796,"ENSG00000110721","K7CE91,Choline kinase alpha","-","PF01633,Choline/ethanolamine kinase","IPR011009,Protein kinase-like domain superfamily","COG0510,Predicted choline kinase involved in LPS biosynthesis;KOG2686,Choline kinase","GO:0016301,molecular_function,kinase activity;GO:0006656,biological_process,phosphatidylcholine biosynthetic process;GO:0042803,molecular_function,protein homodimerization activity;GO:0004305,molecular_function,ethanolamine kinase activity;GO:0006646,biological_process,phosphatidylethanolamine biosynthetic process;GO:0008144,molecular_function,drug binding;GO:0006657,biological_process,CDP-choline pathway;GO:0004103,molecular_function,choline kinase activity;GO:0016310,biological_process,phosphorylation;GO:0004104,molecular_function,cholinesterase activity","-"]
["PHLDB3",7.145187767,3.238492209,1.139811381,4.612093391,0.000335453,9.02074E-4,"ENSG00000176531","G7NM77,Uncharacterized protein","-","PF00169,PH domain","IPR037810,PHLDB1/2/3, PH domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","ENOG410YDTB,-;ENOG410IE1E,-","-","-"]
["ERI2",2.247810871,1.017738847,1.139218299,3.561299214,0.007889908,0.015398046,"ENSG00000196678","H2RDL1,ERI1 exoribonuclease family member 2","XP_009428701.1,-;XP_016785089.1,-;XP_016785088.1,-;XP_009428698.1,-;XP_016785087.1,-;XP_009428697.1,-;XP_009428696.1,ERI1 exoribonuclease 2 isoform X2;XP_009428699.1,-","PF06839,RF zinc finger;PF00929,xonuclease","IPR036397,Ribonuclease H superfamily;IPR010666,Zinc finger, GRF-type;IPR013520,Exonuclease, RNase T/DNA polymerase III;IPR012337,Ribonuclease H-like superfamily","COG5018,Inhibitor of the KinA pathway to sporulation, predicted exonuclease;KOG0542,Predicted exonuclease","GO:0003676,molecular_function,nucleic acid binding;GO:0006259,biological_process,DNA metabolic process;GO:0008270,molecular_function,zinc ion binding","-"]
["ZNF638",13.59199485,6.172912425,1.138382081,6.955892701,{"v":1.05e-06,"d":"1.05E-06"},{"v":4.95E-6,"d":"4.95E-06"},"ENSG00000075292","G3R9W9,Zinc finger protein 638","XP_004029442.2,-;XP_004029441.2,zinc finger protein 638 isoform X1;XP_018876480.1,-;XP_018876479.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF12171,Zinc-finger double-stranded RNA-binding","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR000690,Matrin/U1-C, C2H2-type zinc finger;IPR022755,Zinc finger, double-stranded RNA binding;IPR003604,Matrin/U1-C-like, C2H2-type zinc finger;IPR033096,Zinc finger protein 638;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0008380,biological_process,RNA splicing;GO:0046872,molecular_function,metal ion binding;GO:0003723,molecular_function,RNA binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","-"]
["CASZ1",1.466320587,0.664807625,1.137601871,3.68385621,0.005269081,0.010737662,"ENSG00000130940","A0A0D9S8N4,Castor zinc finger 1","-","-","IPR013087,Zinc finger C2H2-type","-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005829,cellular_component,cytosol;GO:0003676,molecular_function,nucleic acid binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0005654,cellular_component,nucleoplasm","-"]
["AK2",24.17308621,10.98505002,1.137429774,6.665957147,{"v":1.74e-06,"d":"1.74E-06"},{"v":7.82e-06,"d":"7.82E-06"},"ENSG00000004455","A0A0D9S7V6,Adenylate kinase 2, mitochondrial","XP_007977722.1,-","PF00406,Adenylate kinase;PF05191,Adenylate kinase, active site lid","IPR007862,Adenylate kinase, active site lid domain;IPR006259,Adenylate kinase subfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR000850,Adenylate kinase/UMP-CMP kinase;IPR033690,Adenylate kinase, conserved site;IPR028587,Adenylate kinase 2","-","GO:0046034,biological_process,ATP metabolic process;GO:0016301,molecular_function,kinase activity;GO:0006172,biological_process,ADP biosynthetic process;GO:0046939,biological_process,nucleotide phosphorylation;GO:0005758,cellular_component,mitochondrial intermembrane space;GO:0016740,molecular_function,transferase activity;GO:0004017,molecular_function,adenylate kinase activity;GO:0016310,biological_process,phosphorylation;GO:0046033,biological_process,AMP metabolic process;GO:0019205,molecular_function,nucleobase-containing compound kinase activity;GO:0005739,cellular_component,mitochondrion;GO:0006139,biological_process,nucleobase-containing compound metabolic process;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016776,molecular_function,phosphotransferase activity, phosphate group as acceptor","-"]
["WDR44",4.12531904,1.871471366,1.136893673,3.741410412,0.003887699,0.008211673,"ENSG00000131725","K7CB05,WD repeat domain 44","XP_016799140.1,-","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain;IPR020472,G-protein beta WD-40 repeat","-","-","-"]
["NF2",44.01457923,20.01626066,1.13662037,7.84818322,{"v":2.69e-07,"d":"2.69E-07"},{"v":1.43e-06,"d":"1.43E-06"},"ENSG00000186575","A0A024R1J8,Neurofibromin 2","NP_000259.1,merlin isoform 1","PF09379,RM N-terminal domain;PF09380,RM C-terminal PH-like domain;PF00373,RM central domain;PF00769,zrin/radixin/moesin family","IPR019747,FERM conserved site;IPR035963,FERM superfamily, second domain;IPR018980,FERM, C-terminal PH-like domain;IPR000299,FERM domain;IPR019748,FERM central domain;IPR011259,Ezrin/radixin/moesin, C-terminal;IPR011993,PH-like domain superfamily;IPR018979,FERM, N-terminal;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR000798,Ezrin/radixin/moesin-like;IPR011174,Ezrin/radixin/moesin;IPR029071,Ubiquitin-like domain superfamily;IPR008954,Moesin tail domain superfamily","KOG3529,Radixin, moesin and related proteins of the ERM family;ENOG410XQFP,-","GO:0072091,biological_process,regulation of stem cell proliferation;GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0001726,cellular_component,ruffle;GO:0045216,biological_process,cell-cell junction organization;GO:0007398,biological_process,ectoderm development;GO:0005856,cellular_component,cytoskeleton;GO:0005886,cellular_component,plasma membrane;GO:2000177,biological_process,regulation of neural precursor cell proliferation;GO:0005634,cellular_component,nucleus;GO:0043005,cellular_component,neuron projection;GO:0030027,cellular_component,lamellipodium;GO:0014013,biological_process,regulation of gliogenesis;GO:0050767,biological_process,regulation of neurogenesis;GO:0005737,cellular_component,cytoplasm;GO:0005912,cellular_component,adherens junction;GO:0001707,biological_process,mesoderm formation;GO:0042475,biological_process,odontogenesis of dentin-containing tooth;GO:0007420,biological_process,brain development;GO:0045177,cellular_component,apical part of cell;GO:0042127,biological_process,regulation of cell proliferation;GO:0030175,cellular_component,filopodium;GO:0032154,cellular_component,cleavage furrow;GO:0030864,cellular_component,cortical actin cytoskeleton;GO:0003779,molecular_function,actin binding;GO:0031647,biological_process,regulation of protein stability;GO:1900180,biological_process,regulation of protein localization to nucleus;GO:0070306,biological_process,lens fiber cell differentiation;GO:0005829,cellular_component,cytosol;GO:0045597,biological_process,positive regulation of cell differentiation;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0043409,biological_process,negative regulation of MAPK cascade;GO:0021766,biological_process,hippocampus development;GO:0044297,cellular_component,cell body","K16684,ko04392,Hippo signaling pathway -multiple species;K16684,ko04391,Hippo signaling pathway - fly;K16684,ko04390,Hippo signaling pathway"]
["LSR",29.39750084,13.37172495,1.135814111,5.98217769,{"v":9.02E-6,"d":"9.02E-06"},{"v":3.47e-05,"d":"3.47E-05"},"ENSG00000105699","G3QEQ6,Lipolysis stimulated lipoprotein receptor","XP_004060554.1,lipolysis-stimulated lipoprotein receptor isoform X5","PF05624,Lipolysis stimulated receptor (LSR)","IPR003599,Immunoglobulin subtype;IPR036179,Immunoglobulin-like domain superfamily;IPR007110,Immunoglobulin-like domain","-","GO:0061833,biological_process,protein localization to tricellular tight junction;GO:0061689,cellular_component,tricellular tight junction;GO:0001889,biological_process,liver development;GO:1904274,biological_process,tricellular tight junction assembly;GO:0005886,cellular_component,plasma membrane;GO:0060856,biological_process,establishment of blood-brain barrier;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["RBM23",4.674012273,2.126470796,1.135293522,5.600692995,{"v":2.37E-5,"d":"2.37E-05"},{"v":8.29e-05,"d":"8.29E-05"},"ENSG00000100461","A0A0S2Z5D9,RNA binding motif protein 23 isoform 2","NP_001070819.1,probable RNA-binding protein 23 isoform 1;XP_016876896.1,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF15519,linker between RRM2 and RRM3 domains in RBM39 protein","IPR029123,Splicing factor RBM39, linker;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR035979,RNA-binding domain superfamily;IPR000504,RNA recognition motif domain;IPR006509,Splicing factor, RBM39-like","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005634,cellular_component,nucleus;GO:0006397,biological_process,mRNA processing","-"]
["RFC5",5.993146172,2.722964918,1.135081032,3.901370835,2.836889E-3,0.006159479,"ENSG00000111445","K7D694,Replication factor C","XP_001156572.2,replication factor C subunit 5 isoform X1","PF08542,Replication factor C C-terminal domain;PF00004,ATPase family associated with various cellular activities (AAA)","IPR003959,ATPase, AAA-type, core;IPR013748,Replication factor C, C-terminal;IPR003593,AAA+ ATPase domain;IPR008921,DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG0470,ATPase involved in DNA replication;KOG0990,Replication factor C, subunit RFC5","GO:0003689,molecular_function,DNA clamp loader activity;GO:1900264,biological_process,positive regulation of DNA-directed DNA polymerase activity;GO:0019899,molecular_function,enzyme binding;GO:0005663,cellular_component,DNA replication factor C complex;GO:0005524,molecular_function,ATP binding;GO:0043142,molecular_function,single-stranded DNA-dependent ATPase activity;GO:0003677,molecular_function,DNA binding;GO:0006260,biological_process,DNA replication;GO:0031390,cellular_component,Ctf18 RFC-like complex","K10756,ko03420,Nucleotide excision repair;K10756,ko03030,DNA replication;K10756,ko03430,Mismatch repair"]
["ELL",3.950442669,1.794869754,1.135081032,3.901370835,2.836889E-3,0.006159479,"ENSG00000105656","A8KAP0,cDNA FLJ75279, highly similar to Homo sapiens elongation factor RNA polymerase II","-","PF07303,Occludin homology domain;PF10390,RNA polymerase II elongation factor ELL","IPR031184,RNA polymerase II elongation factor ELL;IPR010844,Occludin homology domain;IPR031176,ELL/occludin family;IPR036390,Winged helix DNA-binding domain superfamily;IPR019464,RNA polymerase II elongation factor ELL, N-terminal","KOG4796,RNA polymerase II elongation factor;ENOG410ZNGU,-","GO:0042795,biological_process,snRNA transcription by RNA polymerase II;GO:0006368,biological_process,transcription elongation from RNA polymerase II promoter;GO:0003746,molecular_function,translation elongation factor activity;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0006414,biological_process,translational elongation;GO:0008023,cellular_component,transcription elongation factor complex","-"]
["LPCAT3",4.271769809,1.941709304,1.134562392,3.950953636,0.002632215,0.005780601,"ENSG00000111684","H2Q5B9,Lysophosphatidylcholine acyltransferase 3","XP_508979.2,lysophospholipid acyltransferase 5 isoform X2","PF03062,MBOAT, membrane-bound O-acyltransferase family","IPR004299,Membrane bound O-acyl transferase, MBOAT","KOG2705,Predicted membrane protein;COG5202,Predicted membrane protein","GO:0097006,biological_process,regulation of plasma lipoprotein particle levels;GO:0047184,molecular_function,1-acylglycerophosphocholine O-acyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016021,cellular_component,integral component of membrane","-"]
["KMT5B",5.254273372,2.391426905,1.134310447,5.080308786,1.12823E-4,3.37358E-4,"ENSG00000110066","K7A6Y3,Histone-lysine N-methyltransferase","XP_009421853.2,-","PF00856,SET domain","IPR001214,SET domain;IPR025790,Histone-lysine N-methyltransferase, Suvar4-20","ENOG410XPH8,-;KOG2589,Histone tail methylase","GO:0034773,biological_process,histone H4-K20 trimethylation;GO:0016740,molecular_function,transferase activity;GO:0005634,cellular_component,nucleus;GO:0018024,molecular_function,histone-lysine N-methyltransferase activity;GO:0000780,cellular_component,condensed nuclear chromosome, centromeric region;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0042799,molecular_function,histone methyltransferase activity (H4-K20 specific);GO:0016571,biological_process,histone methylation","K11429,ko00310,Lysine degradation"]
["CSTB",18.78700748,8.553463426,1.133886124,5.124045604,{"v":9.31E-5,"d":"9.31E-05"},0.000282627,"ENSG00000160213","H2P3B6,Cystatin B","XP_002830797.1,-","PF00031,Cystatin domain","IPR001713,Proteinase inhibitor I25A, stefin;IPR000010,Cystatin domain;IPR018073,Proteinase inhibitor I25, cystatin, conserved site","ENOG41121QW,-;ENOG410IZK7,-","GO:0004866,molecular_function,endopeptidase inhibitor activity;GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0010466,biological_process,negative regulation of peptidase activity;GO:0005730,cellular_component,nucleolus;GO:0005737,cellular_component,cytoplasm;GO:0002020,molecular_function,protease binding;GO:0005622,cellular_component,intracellular;GO:0005829,cellular_component,cytosol;GO:0045861,biological_process,negative regulation of proteolysis;GO:0004869,molecular_function,cysteine-type endopeptidase inhibitor activity;GO:0005615,cellular_component,extracellular space","-"]
["CTD-2013N24.2",5.958690245,2.711576828,1.133205679,4.09017348,0.001978868,0.004482816,"ENSG00000244513","Q5RAU2,Uncharacterized protein DKFZp468N152","-","-","-","KOG4673,Transcription factor TMF, TATA element modulatory factor;ENOG410YE9Z,-","-","-"]
["TNFAIP2",16.14861199,7.362491409,1.132415008,5.906241292,{"v":1.15E-5,"d":"1.15E-05"},{"v":4.33e-05,"d":"4.33E-05"},"ENSG00000185215","K7D4L0,Tumor necrosis factor, alpha-induced protein 2","-","PF06046,xocyst complex component Sec6","IPR010326,Exocyst complex component EXOC3/Sec6","-","GO:0000145,cellular_component,exocyst;GO:0006887,biological_process,exocytosis","-"]
["KIAA0141",4.044715556,1.842327953,1.132086689,4.217066531,1.111934E-3,0.002661663,"ENSG00000081791","H2PGW7,KIAA0141","XP_009239419.1,death ligand signal enhancer","PF08238,Sel1 repeat","IPR006597,Sel1-like repeat;IPR011990,Tetratricopeptide-like helical domain superfamily","KOG1550,Extracellular protein SEL-1 and related proteins;COG0790,FOG: TPR repeat, SEL1 subfamily","GO:0008625,biological_process,extrinsic apoptotic signaling pathway via death domain receptors;GO:0043281,biological_process,regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0005739,cellular_component,mitochondrion","-"]
["SEPHS1",14.59695852,6.657770618,1.131514339,5.397838828,{"v":4.8e-05,"d":"4.80E-05"},1.56606E-4,"ENSG00000086475","I3MEL4,Selenophosphate synthetase 1","XP_013217857.1,-;XP_005334325.1,-","PF02769,AIR synthase related protein, C-terminal domain;PF00586,AIR synthase related protein, N-terminal domain","IPR036676,PurM-like, C-terminal domain superfamily;IPR004536,Selenophosphate synthetase;IPR036921,PurM-like, N-terminal domain superfamily;IPR010918,PurM-like, C-terminal domain;IPR016188,PurM-like, N-terminal domain;IPR023061,Selenophosphate synthetase, class I","COG0709,Selenophosphate synthase;KOG3939,Selenophosphate synthetase","GO:0004756,molecular_function,selenide, water dikinase activity;GO:0042802,molecular_function,identical protein binding;GO:0016310,biological_process,phosphorylation;GO:0016260,biological_process,selenocysteine biosynthetic process;GO:0005524,molecular_function,ATP binding","-"]
["HSD17B11",10.62963279,4.844305554,1.131443611,4.295827819,1.118277E-3,0.002676447,"ENSG00000198189","H2R338,Hydroxysteroid","-","PF08659,KR domain;PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily;IPR002347,Short-chain dehydrogenase/reductase SDR","COG1028,Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases);KOG1201,Hydroxysteroid 17-beta dehydrogenase 11","-","-"]
["PRKRA",6.92918465,3.159403936,1.130867796,4.370491796,0.000832786,0.002046424,"ENSG00000180228","H2QJ21,Protein kinase, interferon-inducible double stranded RNA dependent activator","XP_009441943.1,-","PF16482,Staufen C-terminal domain;PF00035,ouble-stranded RNA binding motif","IPR033363,Interferon-inducible double-stranded RNA-dependent protein kinase activator A;IPR032478,Staufen, C-terminal;IPR014720,Double-stranded RNA-binding domain","ENOG410XSCK,-;KOG3732,Staufen and related double-stranded-RNA-binding proteins","GO:0042474,biological_process,middle ear morphogenesis;GO:0048705,biological_process,skeletal system morphogenesis;GO:0070578,cellular_component,RISC-loading complex;GO:0016310,biological_process,phosphorylation;GO:0034599,biological_process,cellular response to oxidative stress;GO:0016301,molecular_function,kinase activity;GO:0050821,biological_process,protein stabilization;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0005622,cellular_component,intracellular;GO:0003725,molecular_function,double-stranded RNA binding;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0035196,biological_process,production of miRNAs involved in gene silencing by miRNA;GO:0030422,biological_process,production of siRNA involved in RNA interference;GO:0043085,biological_process,positive regulation of catalytic activity;GO:0042473,biological_process,outer ear morphogenesis;GO:0008047,molecular_function,enzyme activator activity;GO:2001244,biological_process,positive regulation of intrinsic apoptotic signaling pathway;GO:0006468,biological_process,protein phosphorylation;GO:0005654,cellular_component,nucleoplasm;GO:0019899,molecular_function,enzyme binding;GO:0070883,molecular_function,pre-miRNA binding;GO:0003723,molecular_function,RNA binding;GO:0031054,biological_process,pre-miRNA processing;GO:0043583,biological_process,ear development","-"]
["BRD9",3.22501242,1.471952376,1.129661286,4.541753845,0.000513445,1.326942E-3,"ENSG00000028310","K7ARU8,Bromodomain containing 9","XP_016808377.1,bromodomain-containing protein 9 isoform X3","PF12024,omain of unknown function (DUF3512);PF00439,Bromodomain","IPR036427,Bromodomain-like superfamily;IPR001487,Bromodomain;IPR021900,Protein of unknown function DUF3512","-","-","-"]
["GDI1",6.144326438,2.805337715,1.129253351,4.604924292,0.000395852,1.050362E-3,"ENSG00000203879","G3RCC0,Rab GDP dissociation inhibitor","XP_004065178.1,-","PF00996,P dissociation inhibitor","IPR000806,Rab GDI protein;IPR036188,FAD/NAD(P)-binding domain superfamily;IPR018203,GDP dissociation inhibitor","-","GO:0030496,cellular_component,midbody;GO:0043209,cellular_component,myelin sheath;GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0005093,molecular_function,Rab GDP-dissociation inhibitor activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0050790,biological_process,regulation of catalytic activity;GO:0005096,molecular_function,GTPase activator activity;GO:0005092,molecular_function,GDP-dissociation inhibitor activity;GO:0090315,biological_process,negative regulation of protein targeting to membrane","-"]
["CLIC4",8.293936109,3.79054486,1.128071543,4.806428077,2.70771E-4,0.000744874,"ENSG00000169504","F7EXF2,Chloride intracellular channel protein","XP_002750479.1,-","PF13410,lutathione S-transferase, C-terminal domain","IPR036282,Glutathione S-transferase, C-terminal domain superfamily;IPR010987,Glutathione S-transferase, C-terminal-like;IPR002946,Intracellular chloride channel;IPR036249,Thioredoxin-like superfamily;IPR030257,Chloride intracellular channel protein 4","KOG1422,Intracellular Cl- channel CLIC, contains GST domain;ENOG410ZRK6,-","GO:0001886,biological_process,endothelial cell morphogenesis;GO:0061299,biological_process,retina vasculature morphogenesis in camera-type eye;GO:0035264,biological_process,multicellular organism growth;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0005886,cellular_component,plasma membrane;GO:0016363,cellular_component,nuclear matrix;GO:0030336,biological_process,negative regulation of cell migration;GO:0048754,biological_process,branching morphogenesis of an epithelial tube;GO:0009986,cellular_component,cell surface;GO:0005737,cellular_component,cytoplasm;GO:1902476,biological_process,chloride transmembrane transport;GO:0005739,cellular_component,mitochondrion;GO:0005813,cellular_component,centrosome;GO:0005829,cellular_component,cytosol;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0045177,cellular_component,apical part of cell;GO:0007035,biological_process,vacuolar acidification;GO:0030496,cellular_component,midbody;GO:0006821,biological_process,chloride transport;GO:0034707,cellular_component,chloride channel complex;GO:0005254,molecular_function,chloride channel activity;GO:0005902,cellular_component,microvillus;GO:0006811,biological_process,ion transport;GO:0001525,biological_process,angiogenesis;GO:0016020,cellular_component,membrane;GO:0034220,biological_process,ion transmembrane transport;GO:0005911,cellular_component,cell-cell junction;GO:0071277,biological_process,cellular response to calcium ion;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0030216,biological_process,keratinocyte differentiation;GO:0005622,cellular_component,intracellular;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0009566,biological_process,fertilization","-"]
["SZRD1",28.06301696,12.83871936,1.127726965,6.613907607,{"v":2.4e-06,"d":"2.40E-06"},{"v":1.05e-05,"d":"1.05E-05"},"ENSG00000055070","H2N8X2,SUZ domain-containing protein 1","XP_009232906.1,-","PF12901,SUZ-C motif;PF12752,SUZ domain","IPR024642,SUZ-C domain;IPR024771,SUZ domain","ENOG410IG3N,-;ENOG4111N0B,-","-","-"]
["APOLD1",13.24505021,6.061977308,1.126979949,6.145230389,{"v":7.23e-06,"d":"7.23E-06"},{"v":2.84e-05,"d":"2.84E-05"},"ENSG00000178878","H2Q5H3,Uncharacterized protein","XP_003313549.1,apolipoprotein L domain-containing protein 1 isoform X1","PF05461,Apolipoprotein L","IPR008405,Apolipoprotein L","ENOG410IWGQ,-;ENOG410YM8A,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0006869,biological_process,lipid transport;GO:0005576,cellular_component,extracellular region;GO:0042157,biological_process,lipoprotein metabolic process;GO:0008289,molecular_function,lipid binding","-"]
["HSPG2",2.551313481,1.16731492,1.126742985,5.075157434,1.29274E-4,0.00038178,"ENSG00000142798","A0A024RAB6,Heparan sulfate proteoglycan 2","-","PF00054,Laminin G domain;PF00053,Laminin EGF domain;PF00008,-like domain;PF00052,Laminin B (Domain IV);PF07679,Immunoglobulin I-set domain;PF13927,Immunoglobulin domain;PF13895,Immunoglobulin domain;PF00057,Low-density lipoprotein receptor domain class A","IPR007110,Immunoglobulin-like domain;IPR013106,Immunoglobulin V-set domain;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR000034,Laminin IV;IPR001791,Laminin G domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR000082,SEA domain;IPR003599,Immunoglobulin subtype;IPR001881,EGF-like calcium-binding domain;IPR036179,Immunoglobulin-like domain superfamily;IPR002049,Laminin EGF domain;IPR013783,Immunoglobulin-like fold;IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set;IPR036055,LDL receptor-like superfamily","KOG3509,Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein;ENOG410XTD2,-","GO:0005509,molecular_function,calcium ion binding","-"]
["STAT6",14.99988037,6.869348739,1.12616912,6.333808501,{"v":4.34E-6,"d":"4.34E-06"},{"v":1.79e-05,"d":"1.79E-05"},"ENSG00000166888","B2R680,Signal transducer and activator of transcription","-","PF02864,STAT protein, DNA binding domain;PF01017,STAT protein, all-alpha domain;PF00017,SH2 domain;PF02865,STAT protein, protein interaction domain;PF14596,STAT6 C-terminal","IPR036860,SH2 domain superfamily;IPR015988,STAT transcription factor, coiled coil;IPR035857,STAT6, SH2 domain;IPR036535,STAT transcription factor, N-terminal domain superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR013801,STAT transcription factor, DNA-binding;IPR000980,SH2 domain;IPR012345,STAT transcription factor, DNA-binding, N-terminal;IPR013800,STAT transcription factor, all-alpha domain;IPR028187,STAT6, C-terminal;IPR013799,STAT transcription factor, protein interaction;IPR001217,Transcription factor STAT","KOG3667,STAT protein;ENOG410XPN8,-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0004871,molecular_function,signal transducer activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction","-"]
["CPSF3L",6.268716731,2.870044774,1.125956912,5.262923364,{"v":6.64e-05,"d":"6.64E-05"},0.000209129,"ENSG00000127054","F7G6D8,Integrator complex subunit 11","-","PF16661,Metallo-beta-lactamase superfamily domain","IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR022712,Beta-Casp domain;IPR001279,Metallo-beta-lactamase;IPR011108,Zn-dependent metallo-hydrolase, RNA specificity domain","-","-","-"]
["TEAD1",6.745633079,3.092066755,1.124536826,5.683931454,{"v":2.38e-05,"d":"2.38E-05"},{"v":8.3e-05,"d":"8.30E-05"},"ENSG00000187079","G1S7F8,TEA domain transcription factor 1","-","PF01285,TEA/ATTS domain family","IPR038096,TEA/ATTS domain superfamily;IPR016361,Transcriptional enhancer factor, metazoa;IPR000818,TEA/ATTS domain","ENOG410XQMP,-;KOG3841,TEF-1 and related transcription factor, TEAD family","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0035329,biological_process,hippo signaling;GO:0003677,molecular_function,DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["CAST",85.17509228,39.08902763,1.123612692,9.596751611,{"v":9.88e-08,"d":"9.88E-08"},{"v":5.79e-07,"d":"5.79E-07"},"ENSG00000153113","Q59HE3,Calpastatin isoform a variant","NP_001177371.1,calpastatin isoform m","PF00748,Calpain inhibitor","IPR026998,Calpastatin;IPR001259,Proteinase inhibitor I27, calpastatin","-","-","-"]
["EI24",24.42676031,11.23522774,1.119762727,6.006656388,{"v":9.61e-06,"d":"9.61E-06"},{"v":3.67e-05,"d":"3.67E-05"},"ENSG00000149547","A0A024R3I8,Etoposide induced 2.4 mRNA, isoform CRA_a","XP_011541371.1,-;NP_004870.3,etoposide-induced protein 2.4 homolog isoform 1","PF07264,toposide-induced protein 2.4 (EI24)","IPR009890,Etoposide-induced 2.4","KOG3966,p53-mediated apoptosis protein EI24/PIG8;ENOG410XRPU,-","GO:0005829,cellular_component,cytosol;GO:0005794,cellular_component,Golgi apparatus;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K10134,ko04115,p53 signaling pathway"]
["SIKE1",10.39442102,4.78097324,1.119482329,5.509820111,{"v":4.09e-05,"d":"4.09E-05"},1.35511E-4,"ENSG00000052723","A0A096MMI9,Suppressor of IKBKE 1","XP_003892492.1,-","PF05769,SIKE family","IPR008555,SIKE family","-","GO:0019901,molecular_function,protein kinase binding;GO:0017048,molecular_function,Rho GTPase binding","-"]
["RP4-559A3.7",26.30327763,12.09834259,1.119070825,5.001275571,0.000146626,0.000429106,"ENSG00000255835","J3KR12,Uncharacterized protein","-","PF03807,NADP oxidoreductase coenzyme F420-dependent;PF14748,Pyrroline-5-carboxylate reductase dimerisation","IPR036291,NAD(P)-binding domain superfamily;IPR028939,Pyrroline-5-carboxylate reductase, catalytic, N-terminal;IPR029036,Pyrroline-5-carboxylate reductase, dimerisation domain;IPR008927,6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily;IPR000304,Pyrroline-5-carboxylate reductase","KOG3124,Pyrroline-5-carboxylate reductase;COG0345,Pyrroline-5-carboxylate reductase","GO:0055114,biological_process,oxidation-reduction process;GO:0004735,molecular_function,pyrroline-5-carboxylate reductase activity;GO:0006561,biological_process,proline biosynthetic process","-"]
["uc_338",6.022112088,2.769904807,1.118830773,4.772943589,0.000251338,0.000697857,"-","-","-","-","-","-","-","-"]
["AF011889.5",10.32747234,4.750179814,1.118730784,4.687998905,0.000389303,1.034009E-3,"ENSG00000241489","B3KWA1,Iduronate 2-sulfatase","-","PF00884,Sulfatase","IPR000917,Sulfatase, N-terminal;IPR017850,Alkaline-phosphatase-like, core domain superfamily;IPR017849,Alkaline phosphatase-like, alpha/beta/alpha","KOG3867,Sulfatase;COG3119,Arylsulfatase A and related enzymes","GO:0008484,molecular_function,sulfuric ester hydrolase activity;GO:0003824,molecular_function,catalytic activity;GO:0008152,biological_process,metabolic process","-"]
["SOCS4",4.248186612,1.953977665,1.11848803,4.501383737,0.00075601,0.001876383,"ENSG00000180008","Q5H9R6,Full-length cDNA clone CS0DD006YF02 of Neuroblastoma of Homo sapiens","NP_955453.1,-;NP_543143.1,suppressor of cytokine signaling 4;XP_011534728.1,-;XP_011534727.1,-","PF07525,SOCS box;PF12610,Suppressor of cytokine signalling;PF00017,SH2 domain","IPR001496,SOCS box domain;IPR036860,SH2 domain superfamily;IPR036036,SOCS box-like domain superfamily;IPR000980,SH2 domain;IPR037342,SOCS4, SOCS box domain;IPR022252,SOCS4/SOCS5 domain;IPR028416,Suppressor of cytokine signalling 4;IPR035864,SOCS4, SH2 domain","KOG4566,Cytokine-inducible SH2 protein;ENOG4111V4J,-","GO:0032436,biological_process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0005622,cellular_component,intracellular;GO:0007175,biological_process,negative regulation of epidermal growth factor-activated receptor activity;GO:0035556,biological_process,intracellular signal transduction;GO:0016567,biological_process,protein ubiquitination","K04697,ko04930,Type II diabetes mellitus;K04697,ko04630,Jak-STAT signaling pathway;K04697,ko04910,Insulin signaling pathway;K04697,ko04917,Prolactin signaling pathway"]
["ALDH9A1",8.829382669,4.061124924,1.118440676,4.467781347,0.00059571,1.513541E-3,"ENSG00000143149","B9EKV4,Aldehyde dehydrogenase 9 family, member A1","NP_000687.3,4-trimethylaminobutyraldehyde dehydrogenase","PF00171,Aldehyde dehydrogenase family","IPR016163,Aldehyde dehydrogenase, C-terminal;IPR016160,Aldehyde dehydrogenase, cysteine active site;IPR015590,Aldehyde dehydrogenase domain;IPR016162,Aldehyde dehydrogenase, N-terminal;IPR016161,Aldehyde/histidinol dehydrogenase;IPR029510,Aldehyde dehydrogenase, glutamic acid active site","COG1012,NAD-dependent aldehyde dehydrogenases;KOG2450,Aldehyde dehydrogenase","GO:0016620,molecular_function,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0008152,biological_process,metabolic process","K00149,ko00010,Glycolysis / Gluconeogenesis;K00149,ko00340,Histidine metabolism;K00149,ko00561,Glycerolipid metabolism;K00149,ko00620,Pyruvate metabolism;K00149,ko00053,Ascorbate and aldarate metabolism;K00149,ko00330,Arginine and proline metabolism;K00149,ko00280,Valine, leucine and isoleucine degradation;K00149,ko00310,Lysine degradation;K00149,ko00071,Fatty acid degradation;K00149,ko00380,Tryptophan metabolism;K00149,ko00410,beta-Alanine metabolism"]
["LRSAM1",6.364911111,2.927577173,1.118338697,4.398122162,0.00078831,1.948438E-3,"ENSG00000148356","A0A024R870,Leucine rich repeat and sterile alpha motif containing 1, isoform CRA_a","XP_016870772.1,-;NP_612370.3,E3 ubiquitin-protein ligase LRSAM1 isoform 1;NP_001005373.1,-;NP_001005374.1,-","PF13855,Leucine rich repeat;PF13920,Zinc finger, C3HC4 type (RING finger);PF07647,SAM domain (Sterile alpha motif)","IPR001611,Leucine-rich repeat;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR001841,Zinc finger, RING-type;IPR003591,Leucine-rich repeat, typical subtype;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001660,Sterile alpha motif domain","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0005829,cellular_component,cytosol","-"]
["SLC25A1",12.91529416,5.940463222,1.118283691,4.361983088,0.000995102,0.002403087,"ENSG00000100075","G3QTN4,Solute carrier family 25 member 1","XP_004063062.1,-","PF00153,Mitochondrial carrier protein","IPR018108,Mitochondrial substrate/solute carrier;IPR023395,Mitochondrial carrier domain superfamily;IPR002067,Mitochondrial carrier protein","-","GO:0055085,biological_process,transmembrane transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SNAPC4",4.2361572,1.948444668,1.117711959,4.034529042,1.864264E-3,0.004246511,"ENSG00000165684","A0A024R8F4,Small nuclear RNA activating complex, polypeptide 4, 190kDa, isoform CRA_a","XP_006717304.1,-;XP_006717305.1,-;XP_005266153.1,-;NP_003077.2,snRNA-activating protein complex subunit 4","PF13921,Myb-like DNA-binding domain;PF00249,Myb-like DNA-binding domain","IPR017877,Myb-like domain;IPR001005,SANT/Myb domain;IPR009057,Homeobox-like domain superfamily;IPR031282,snRNA-activating protein complex subunit 4;IPR017930,Myb domain","KOG0048,Transcription factor, Myb superfamily;COG5147,Myb superfamily proteins, including transcription factors and mRNA splicing factors","GO:0003677,molecular_function,DNA binding;GO:0009301,biological_process,snRNA transcription;GO:0019185,cellular_component,snRNA-activating protein complex","-"]
["LCMT1",7.927487582,3.646293134,1.117618372,3.98779445,0.002445889,0.005409799,"ENSG00000205629","K7CM25,Leucine carboxyl methyltransferase 1","-","PF04072,Leucine carboxyl methyltransferase","IPR016651,Leucine carboxyl methyltransferase 1, LCMT1;IPR007213,Methyltransferase Ppm1/Ppm2/Tcmp;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase","ENOG410YB9K,-;KOG2918,Carboxymethyl transferase","GO:0032259,biological_process,methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0016740,molecular_function,transferase activity","-"]
["ZKSCAN5",3.293700826,1.514956483,1.117518118,3.939484326,0.00322592,0.006919197,"ENSG00000196652","Q8N718,ZKSCAN5 protein","NP_001305011.1,-;NP_001305013.1,zinc finger protein with KRAB and SCAN domains 5 isoform c","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF02023,SCAN domain","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR003309,SCAN domain;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR038269,SCAN domain superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005622,cellular_component,intracellular;GO:0005634,cellular_component,nucleus","-"]
["ZNF134",3.743532847,1.721859287,1.117410459,3.889488259,0.003486207,0.007426996,"ENSG00000213762","K7A9G1,Zinc finger protein 134","-","PF00096,Zinc finger, C2H2 type","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["TOR4A",4.293517574,1.974827899,1.117169381,3.783934538,0.003584452,0.007622171,"ENSG00000198113","H2R2W6,Chromosome 9 open reading frame 167","XP_528518.2,torsin-4A isoform X2","PF06309,Torsin","IPR010448,Torsin;IPR003593,AAA+ ATPase domain;IPR030551,Torsin-4A;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG2170,ATPase of the AAA+ superfamily;ENOG410XR06,-","GO:0005524,molecular_function,ATP binding","-"]
["UFC1",6.26543919,2.881824495,1.116356551,3.479955769,0.007583229,0.014918936,"ENSG00000143222","I3N545,Ubiquitin-fold modifier-conjugating enzyme 1","XP_005341895.1,-","PF08694,Ubiquitin-fold modifier-conjugating enzyme 1","IPR014806,Ubiquitin-fold modifier-conjugating enzyme 1;IPR016135,Ubiquitin-conjugating enzyme/RWD-like","KOG3357,Uncharacterized conserved protein;ENOG410ZBCX,-","GO:0071568,molecular_function,UFM1 transferase activity;GO:1990592,biological_process,protein K69-linked ufmylation;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0071569,biological_process,protein ufmylation","-"]
["SLC1A5",76.11267562,35.10679769,1.116157672,7.54042586,{"v":6.35e-07,"d":"6.35E-07"},{"v":3.13e-06,"d":"3.13E-06"},"ENSG00000105281","K7BJW4,Amino acid transporter","XP_016791789.1,neutral amino acid transporter B(0) isoform X1","PF00375,Sodium:dicarboxylate symporter family","IPR001991,Sodium:dicarboxylate symporter;IPR018107,Sodium:dicarboxylate symporter, conserved site;IPR036458,Sodium:dicarboxylate symporter superfamily","KOG3787,Glutamate/aspartate and neutral amino acid transporters;COG1301,Na+/H+-dicarboxylate symporters","GO:0055085,biological_process,transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0015293,molecular_function,symporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K05616,ko05230,Central carbon metabolism in cancer;K05616,ko04974,Protein digestion and absorption"]
["GMPPB",2.00759838,0.923406327,1.116142855,3.410554742,0.010578883,0.019972545,"ENSG00000173540","A0A024R329,GDP-mannose pyrophosphorylase B, isoform CRA_a","-","PF00132,Bacterial transferase hexapeptide (six repeats);PF00483,Nucleotidyl transferase","IPR011004,Trimeric LpxA-like superfamily;IPR001451,Hexapeptide repeat;IPR029044,Nucleotide-diphospho-sugar transferases;IPR018357,Hexapeptide transferase, conserved site;IPR005835,Nucleotidyl transferase domain","COG1208,Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon);KOG1322,GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase","GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0009058,biological_process,biosynthetic process;GO:0005739,cellular_component,mitochondrion","-"]
["NOMO2",1.885435648,0.867216882,1.115905515,3.337608111,0.011720469,0.021894082,"ENSG00000185164","J3KN36,Nodal modulator 3","XP_005255375.1,nodal modulator 3 isoform X1","PF13620,Carboxypeptidase regulatory-like domain","IPR008969,Carboxypeptidase-like, regulatory domain superfamily;IPR013784,Carbohydrate-binding-like fold","KOG1948,Metalloproteinase-related collagenase pM5;ENOG410XTI0,-","GO:0030246,molecular_function,carbohydrate binding","-"]
["METRNL",4.611754535,2.121202805,1.115640378,3.260732025,0.016577892,0.029828714,"ENSG00000176845","H9F471,Meteorin-like protein","-","-","-","ENOG4111N7F,-;ENOG410IGT2,-","-","-"]
["TMEM70",4.061189607,1.867967326,1.115640378,3.260732025,0.016577892,0.029828714,"ENSG00000175606","K7A406,Transmembrane protein 70","XP_016815069.1,transmembrane protein 70, mitochondrial isoform X1","PF06979,Assembly, mitochondrial proton-transport ATP synth complex","IPR009724,TMEM70 family","-","GO:0032592,cellular_component,integral component of mitochondrial membrane;GO:0033615,biological_process,mitochondrial proton-transporting ATP synthase complex assembly;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["FAM76A",2.648910892,1.218381675,1.115004589,3.093309744,0.018130153,0.032076577,"ENSG00000009780","H2PYG0,Uncharacterized protein","-","PF16046,AM76 protein","-","-","-","-"]
["NR2F1-AS1",1.291881619,0.59420832,1.114618944,3.001596029,0.026404938,0.044838522,"ENSG00000237187","A0A024RAQ6,HCG1649176, isoform CRA_a","-","-","-","-","-","-"]
["SLC44A3",3.227935053,1.48470714,1.114174318,2.903567835,0.029906776,0.050249504,"ENSG00000143036","H2PZF6,Uncharacterized protein","XP_003308271.1,choline transporter-like protein 3 isoform X5;XP_009424034.1,-","PF04515,Plasma-membrane choline transporter","IPR007603,Choline transporter-like","KOG1362,Choline transporter-like protein;ENOG410XS0P,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["BAIAP2",6.001131199,2.770870891,1.113958145,5.522440075,{"v":4.01e-05,"d":"4.01E-05"},1.33313E-4,"ENSG00000175866","I3L4C2,Brain-specific angiogenesis inhibitor 1-associated protein 2","XP_005257002.1,brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X6","PF14604,Variant SH3 domain;PF08397,IRSp53/MIM homology domain","IPR035594,IRSp53, SH3 domain;IPR030128,I-BAR domain containing protein IRSp53;IPR036028,SH3-like domain superfamily;IPR013606,IMD/I-BAR domain;IPR001452,SH3 domain;IPR027681,I-BAR domain containing protein IRSp53/IRTKS/Pinkbar;IPR027267,AH/BAR domain superfamily","-","GO:0005829,cellular_component,cytosol;GO:0007009,biological_process,plasma membrane organization;GO:0005886,cellular_component,plasma membrane;GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:0008093,molecular_function,cytoskeletal adaptor activity","-"]
["ANKRD36",0.884029496,0.40661441,1.113656057,2.79828607,0.044334801,0.07062174,"ENSG00000135976","H2R3G5,Uncharacterized protein","-","PF12796,Ankyrin repeats (3 copies);PF00023,Ankyrin repeat;PF14915,CCDC144C protein coiled-coil region","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","-","-"]
["TXNRD3",2.798221025,1.287057722,1.113656057,2.79828607,0.044334801,0.07062174,"ENSG00000197763","H0YBQ0,Thioredoxin reductase 3","-","PF00462,lutaredoxin;PF00070,Pyridine nucleotide-disulphide oxidoreductase;PF02852,Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain;PF00890,AD binding domain;PF07992,Pyridine nucleotide-disulphide oxidoreductase;PF13738,Pyridine nucleotide-disulphide oxidoreductase","IPR023753,FAD/NAD(P)-binding domain;IPR012999,Pyridine nucleotide-disulphide oxidoreductase, class I, active site;IPR036249,Thioredoxin-like superfamily;IPR001100,Pyridine nucleotide-disulphide oxidoreductase, class I;IPR006338,Thioredoxin/glutathione reductase selenoprotein;IPR036188,FAD/NAD(P)-binding domain superfamily;IPR004099,Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain;IPR011899,Glutaredoxin, eukaryotic/virial;IPR002109,Glutaredoxin;IPR016156,FAD/NAD-linked reductase, dimerisation domain superfamily","KOG1752,Glutaredoxin and related proteins;COG1249,Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes;KOG4716,Thioredoxin reductase","GO:0022900,biological_process,electron transport chain;GO:0045454,biological_process,cell redox homeostasis;GO:0016668,molecular_function,oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0098869,biological_process,cellular oxidant detoxification;GO:0009055,molecular_function,electron transfer activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0004791,molecular_function,thioredoxin-disulfide reductase activity;GO:0015035,molecular_function,protein disulfide oxidoreductase activity;GO:0005829,cellular_component,cytosol;GO:0055114,biological_process,oxidation-reduction process;GO:0005654,cellular_component,nucleoplasm","-"]
["MTMR11",1.706857938,0.785079045,1.113044219,2.684584958,0.033509944,0.055389793,"ENSG00000014914","G3QQ15,Myotubularin related protein 11","XP_004026605.2,myotubularin-related protein 11","PF06602,Myotubularin-like phosphatase domain;PF12578,Myotubularin-associated protein","IPR030564,Myotubularin family;IPR029021,Protein-tyrosine phosphatase-like;IPR022587,Myotubularin-related 12-like C-terminal domain;IPR030580,Myotubularin-related protein 11;IPR010569,Myotubularin-like phosphatase domain","-","-","-"]
["PAAF1",0.987298072,0.45411338,1.113044219,2.684584958,0.033509944,0.055389793,"ENSG00000175575","F5H0C4,Proteasomal ATPase-associated factor 1","XP_005274365.2,proteasomal ATPase-associated factor 1 isoform X1","PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat","ENOG410XWCN,-;ENOG410IQ12,-","-","-"]
["ANKRD46",1.346423504,0.619295171,1.113044219,2.684584958,0.033509944,0.055389793,"ENSG00000186106","A0A024R9G2,Ankyrin repeat domain 46, isoform CRA_a","NP_001257308.1,ankyrin repeat domain-containing protein 46 isoform 2","PF12796,Ankyrin repeats (3 copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0508,Ankyrin repeat protein;COG0666,FOG: Ankyrin repeat","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MLEC",14.12822521,6.530849567,1.112629831,6.135441257,{"v":9.25e-06,"d":"9.25E-06"},{"v":3.54E-5,"d":"3.54E-05"},"ENSG00000110917","G3QWB0,Malectin","XP_004054067.1,-","PF11721,i-glucose binding within endoplasmic reticulum","IPR021720,Malectin","-","GO:0019899,molecular_function,enzyme binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["AGPAT1",23.11218993,10.6894788,1.111789669,5.98950707,{"v":1.27E-5,"d":"1.27E-05"},{"v":4.71E-5,"d":"4.71E-05"},"ENSG00000204310","G3RMU5,1-acyl-sn-glycerol-3-phosphate acyltransferase","XP_004043795.1,-","PF01553,Acyltransferase","IPR004552,1-acyl-sn-glycerol-3-phosphate acyltransferase;IPR002123,Phospholipid/glycerol acyltransferase","-","GO:0006629,biological_process,lipid metabolic process;GO:0008654,biological_process,phospholipid biosynthetic process;GO:0016740,molecular_function,transferase activity;GO:0003841,molecular_function,1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016021,cellular_component,integral component of membrane","K13509,ko04072,Phospholipase D signaling pathway;K13509,ko00564,Glycerophospholipid metabolism;K13509,ko00561,Glycerolipid metabolism;K13509,ko04975,Fat digestion and absorption"]
["ATP5A1",7.793429777,3.604658362,1.111717485,5.977644785,{"v":1.28e-05,"d":"1.28E-05"},{"v":4.75e-05,"d":"4.75E-05"},"ENSG00000152234","K7DNH8,ATP synthase subunit alpha","-","PF00306,ATP synthase alpha/beta chain, C terminal domain;PF02874,ATP synthase alpha/beta family, beta-barrel domain;PF00006,ATP synthase alpha/beta family, nucleotide-binding domain","IPR000793,ATP synthase, alpha subunit, C-terminal;IPR020003,ATPase, alpha/beta subunit, nucleotide-binding domain, active site;IPR000194,ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004100,ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain;IPR036121,ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily;IPR005294,ATP synthase, F1 complex, alpha subunit;IPR033732,ATP synthase, F1 complex, alpha subunit nucleotide-binding domain;IPR038376,ATP synthase, alpha subunit, C-terminal domain superfamily;IPR023366,ATP synthase subunit alpha, N-terminal domain-like superfamily","KOG1353,F0F1-type ATP synthase, alpha subunit;COG0056,F0F1-type ATP synthase, alpha subunit","GO:0046034,biological_process,ATP metabolic process;GO:0015986,biological_process,ATP synthesis coupled proton transport;GO:0046933,molecular_function,proton-transporting ATP synthase activity, rotational mechanism;GO:0000166,molecular_function,nucleotide binding;GO:0045261,cellular_component,proton-transporting ATP synthase complex, catalytic core F(1);GO:0006754,biological_process,ATP biosynthetic process;GO:0006811,biological_process,ion transport;GO:0032559,molecular_function,adenyl ribonucleotide binding;GO:0099132,biological_process,ATP hydrolysis coupled cation transmembrane transport;GO:0005524,molecular_function,ATP binding","-"]
["ATG12",4.622030281,2.138217801,1.110715583,4.947941584,0.000208237,0.00058906,"ENSG00000145782","C1IDX9,Ubiquitin-like protein ATG12","-","PF04110,Ubiquitin-like autophagy protein Apg12","IPR029071,Ubiquitin-like domain superfamily;IPR007242,Ubiquitin-like protein Atg12","ENOG4111ND7,-;KOG3439,Protein conjugation factor involved in autophagy","GO:0005737,cellular_component,cytoplasm;GO:0006914,biological_process,autophagy;GO:0000045,biological_process,autophagosome assembly","-"]
["LIMA1",48.34157778,22.4078848,1.109069922,7.809503993,{"v":5.4e-07,"d":"5.40E-07"},{"v":2.7E-6,"d":"2.70E-06"},"ENSG00000050405","H2Q5W9,Uncharacterized protein","-","PF00412,LIM domain","IPR001781,Zinc finger, LIM-type;IPR028740,LIM domain and actin-binding protein 1","ENOG410ITI7,-;ENOG41102B0,-","GO:0001725,cellular_component,stress fiber;GO:0005925,cellular_component,focal adhesion;GO:0005903,cellular_component,brush border;GO:0015629,cellular_component,actin cytoskeleton;GO:0032154,cellular_component,cleavage furrow;GO:0046872,molecular_function,metal ion binding;GO:0030835,biological_process,negative regulation of actin filament depolymerization;GO:0005886,cellular_component,plasma membrane;GO:0051017,biological_process,actin filament bundle assembly;GO:0045296,molecular_function,cadherin binding;GO:0031529,biological_process,ruffle organization;GO:0005829,cellular_component,cytosol;GO:0051015,molecular_function,actin filament binding;GO:0003785,molecular_function,actin monomer binding","-"]
["ARMC8",3.303415912,1.530515686,1.108175566,4.621358496,4.45635E-4,1.163655E-3,"ENSG00000114098","A0A096N7B9,Armadillo repeat containing 8","XP_009199904.1,-","PF00514,Armadillo/beta-catenin-like repeat","IPR000225,Armadillo;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","-","-","-"]
["MDM2",12.24076715,5.67959849,1.107480058,6.9039585,{"v":2.1e-06,"d":"2.10E-06"},{"v":9.3e-06,"d":"9.30E-06"},"ENSG00000135679","H2R792,Mdm2 p53 binding protein homolog","XP_001155208.1,E3 ubiquitin-protein ligase Mdm2 isoform X1","PF13920,Zinc finger, C3HC4 type (RING finger);PF00641,Zn-finger in Ran binding protein and others;PF02201,SWIB/MDM2 domain","IPR003121,SWIB/MDM2 domain;IPR036885,SWIB/MDM2 domain superfamily;IPR028340,E3 ubiquitin-protein ligase Mdm2;IPR036443,Zinc finger, RanBP2-type superfamily;IPR001841,Zinc finger, RING-type;IPR015459,Ubiquitin-protein ligase E3 MDM2;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR016495,p53 negative regulator Mdm2/Mdm4;IPR001876,Zinc finger, RanBP2-type","ENOG41125MP,-;ENOG410IGXG,-","GO:0071157,biological_process,negative regulation of cell cycle arrest;GO:0016567,biological_process,protein ubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0046872,molecular_function,metal ion binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus","K06643,ko05218,Melanoma;K06643,ko05200,Pathways in cancer;K06643,ko05205,Proteoglycans in cancer;K06643,ko05215,Prostate cancer;K06643,ko04144,Endocytosis;K06643,ko05214,Glioma;K06643,ko04068,FoxO signaling pathway;K06643,ko05220,Chronic myeloid leukemia;K06643,ko01522,Endocrine resistance;K06643,ko05203,Viral carcinogenesis;K06643,ko05202,Transcriptional misregulation in cancer;K06643,ko05169,Epstein-Barr virus infection;K06643,ko01524,Platinum drug resistance;K06643,ko05206,MicroRNAs in cancer;K06643,ko04115,p53 signaling pathway;K06643,ko04151,PI3K-Akt signaling pathway;K06643,ko04120,Ubiquitin mediated proteolysis;K06643,ko04110,Cell cycle;K06643,ko05219,Bladder cancer;K06643,ko04919,Thyroid hormone signaling pathway"]
["HERC2",1.446554038,0.670804476,1.106677427,4.459839368,0.000708295,1.76695E-3,"ENSG00000128731","K7DSB5,Hect domain and RLD 2","-","PF03256,Anaphase-promoting complex, subunit 10 (APC10);PF06701,Mib_herc2;PF00569,Zinc finger, ZZ type;PF00173,Cytochrome b5-like Heme/Steroid binding domain;PF11515,Mouse development and cellular proliferation protein Cullin-7;PF00632,HECT-domain (ubiquitin-transferase);PF00415,Regulator of chromosome condensation (RCC1) repeat","IPR004939,APC10/DOC domain;IPR021097,CPH domain;IPR000569,HECT domain;IPR009091,Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II;IPR010606,Mib-herc2;IPR001199,Cytochrome b5-like heme/steroid binding domain;IPR008979,Galactose-binding-like domain superfamily;IPR000408,Regulator of chromosome condensation, RCC1;IPR006624,Beta-propeller repeat TECPR;IPR036400,Cytochrome b5-like heme/steroid binding domain superfamily;IPR000433,Zinc finger, ZZ-type;IPR037976,HERC2, APC10 domain;IPR037252,Mib/herc2 domain superfamily;IPR035983,HECT, E3 ligase catalytic domain;IPR014722,Ribosomal protein L2, domain 2","KOG1426,FOG: RCC1 domain;COG5021,Ubiquitin-protein ligase;COG5184,Alpha-tubulin suppressor and related RCC1 domain-containing proteins","GO:0046872,molecular_function,metal ion binding;GO:0016567,biological_process,protein ubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0008270,molecular_function,zinc ion binding;GO:0016740,molecular_function,transferase activity","-"]
["RP11-458D21.5",8.075454955,3.746371843,1.105970362,4.389777894,9.40112E-4,0.002277811,"ENSG00000213240","A0A087X002,Uncharacterized protein","-","PF00008,-like domain;PF07645,Calcium-binding EGF domain;PF12661,Human growth factor-like EGF","IPR013032,EGF-like, conserved site;IPR001881,EGF-like calcium-binding domain;IPR018097,EGF-like calcium-binding, conserved site;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain","ENOG410XP6K,-;KOG1217,Fibrillins and related proteins containing Ca2+-binding EGF-like domains","GO:0005509,molecular_function,calcium ion binding","-"]
["MDN1",3.752998748,1.743827603,1.104967495,5.699584803,{"v":2.83E-5,"d":"2.83E-05"},{"v":9.74e-05,"d":"9.74E-05"},"ENSG00000112159","K7BT84,Midasin","-","PF07728,AAA domain (dynein-related subfamily)","-","-","-","-"]
["ST3GAL4",5.211891207,2.421700714,1.103333515,4.156394262,2.088739E-3,0.004694048,"ENSG00000110080","Q8NFD3,Alpha-2,3-sialyltransferase IV type A1+18","-","PF00777,lycosyltransferase family 29 (sialyltransferase)","IPR012163,Sialyltransferase;IPR038578,GT29-like superfamiliy;IPR001675,Glycosyl transferase family 29","KOG2692,Sialyltransferase;ENOG410XT8P,-","GO:0005794,cellular_component,Golgi apparatus;GO:0097503,biological_process,sialylation;GO:0006486,biological_process,protein glycosylation;GO:0016740,molecular_function,transferase activity;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016020,cellular_component,membrane;GO:0008373,molecular_function,sialyltransferase activity;GO:0003836,molecular_function,beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["MED28",3.913702995,1.820020957,1.103251797,5.013808875,0.000163199,0.000471435,"ENSG00000118579","H2QP97,Mediator complex subunit 28","-","PF11594,Mediator complex subunit 28","-","-","-","-"]
["RP11-140K17.3",53.89821715,25.07411577,1.102666818,4.966524015,2.31375E-4,0.000645771,"ENSG00000272288","G9KQU9,SAM pointed domain containing ets transcription factor","-","PF14555,UBA-like domain;PF16158,Ig-like domain from next to BRCA1 gene","IPR032350,Next to BRCA1, central domain;IPR009060,UBA-like superfamily;IPR013783,Immunoglobulin-like fold","KOG4351,Uncharacterized conserved protein;ENOG410ZKCZ,-","-","-"]
["AKAP8",13.10010578,6.101740132,1.10127476,5.395074065,{"v":7.52e-05,"d":"7.52E-05"},2.34224E-4,"ENSG00000105127","Q8NE02,AKAP8 protein","-","PF04988,A-kinase anchoring protein 95 (AKAP95)","IPR034736,Zinc finger C2H2 AKAP95-type;IPR007071,A-kinase anchoring protein 95 (AKAP95)","ENOG410IFNG,-;ENOG410YE5A,-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["RAB11FIP4",2.469844845,1.150219465,1.101013882,4.841029465,0.000290601,0.000794267,"ENSG00000131242","U3FMJ8,Rab11 family-interacting protein 4","-","PF09457,IP domain","IPR002048,EF-hand domain;IPR011992,EF-hand domain pair;IPR019018,Rab-binding domain FIP-RBD;IPR037245,FIP-RBD, C-terminal domain superfamily","-","GO:0005509,molecular_function,calcium ion binding","-"]
["SMARCA2",3.047176431,1.420506265,1.099990242,5.302954448,{"v":8.72e-05,"d":"8.72E-05"},0.000266221,"ENSG00000080503","F7DUE0,SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2","XP_014973296.1,probable global transcription activator SNF2L2 isoform X1;XP_014973297.1,-;XP_014973300.1,-;XP_014973299.1,-;XP_014973298.1,-","PF00271,Helicase conserved C-terminal domain;PF07533,BRK domain;PF00176,SNF2 family N-terminal domain;PF14619,Snf2-ATP coupling, chromatin remodelling complex;PF00439,Bromodomain;PF07529,HSA","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR014012,Helicase/SANT-associated domain;IPR029295,Snf2, ATP coupling domain;IPR014978,Glutamine-Leucine-Glutamine, QLQ;IPR030088,SWI/SNF complex subunit SMARCA2;IPR036427,Bromodomain-like superfamily;IPR006576,BRK domain;IPR001487,Bromodomain;IPR018359,Bromodomain, conserved site;IPR037259,BRK domain superfamily;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR001650,Helicase, C-terminal","COG0553,Superfamily II DNA/RNA helicases, SNF2 family;KOG0386,Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily);COG5076,Transcription factor involved in chromatin remodeling, contains bromodomain","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0016514,cellular_component,SWI/SNF complex;GO:0016887,molecular_function,ATPase activity;GO:0016817,molecular_function,hydrolase activity, acting on acid anhydrides;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006338,biological_process,chromatin remodeling;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030308,biological_process,negative regulation of cell growth;GO:0045111,cellular_component,intermediate filament cytoskeleton;GO:0001105,molecular_function,RNA polymerase II transcription coactivator activity;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0042393,molecular_function,histone binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0000790,cellular_component,nuclear chromatin;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005524,molecular_function,ATP binding;GO:0005654,cellular_component,nucleoplasm","-"]
["QRSL1",3.483735856,1.622393731,1.099520765,3.877502511,0.004277384,0.008944379,"ENSG00000130348","H2QTH5,Glutamyl-tRNA","XP_518663.2,-","PF01425,Amidase","IPR023631,Amidase signature domain;IPR036928,Amidase signature (AS) superfamily;IPR000120,Amidase;IPR004412,Glutamyl-tRNA(Gln) amidotransferase A subunit","KOG1211,Amidases;COG0154,Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases","GO:0070681,biological_process,glutaminyl-tRNAGln biosynthesis via transamidation;GO:0005524,molecular_function,ATP binding;GO:0004040,molecular_function,amidase activity;GO:0030956,cellular_component,glutamyl-tRNA(Gln) amidotransferase complex;GO:0032543,biological_process,mitochondrial translation;GO:0005739,cellular_component,mitochondrion;GO:0006412,biological_process,translation;GO:0050567,molecular_function,glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity;GO:0000166,molecular_function,nucleotide binding;GO:0016884,molecular_function,carbon-nitrogen ligase activity, with glutamine as amido-N-donor;GO:0016874,molecular_function,ligase activity","-"]
["RP11-20I23.3",55.3808057,25.83923141,1.09810566,4.644619543,0.000559467,0.001433678,"ENSG00000259784","H3BQ15,Uncharacterized protein","-","-","IPR032466,Metal-dependent hydrolase","KOG3892,N-acetyl-glucosamine-6-phosphate deacetylase;COG1820,N-acetylglucosamine-6-phosphate deacetylase","GO:0008448,molecular_function,N-acetylglucosamine-6-phosphate deacetylase activity;GO:0006046,biological_process,N-acetylglucosamine catabolic process;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CCDC69",3.519337222,1.640614085,1.097841663,3.771009239,0.004443335,0.009227726,"ENSG00000198624","G3QUF5,Coiled-coil domain containing 69","XP_004042890.1,coiled-coil domain-containing protein 69","-","-","-","GO:0051255,biological_process,spindle midzone assembly;GO:0051233,cellular_component,spindle midzone","-"]
["TRAM1",23.32963263,10.8995834,1.097265024,6.070806773,{"v":1.48e-05,"d":"1.48E-05"},{"v":5.42e-05,"d":"5.42E-05"},"ENSG00000067167","Q6FHL3,Translocating chain-associated membrane protein","NP_055109.1,translocating chain-associated membrane protein 1 isoform 1","PF03798,TLC domain;PF08390,TRAM1-like protein","IPR006634,TRAM/LAG1/CLN8 homology domain;IPR013599,TRAM1-like protein;IPR016447,Translocation associated membrane protein","KOG1608,Protein transporter of the TRAM (translocating chain-associating membrane) superfamily;ENOG410XSB3,-","GO:0015031,biological_process,protein transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K14010,ko04141,Protein processing in endoplasmic reticulum"]
["SFXN3",3.640611167,1.69810466,1.096896767,3.714635671,0.005999808,0.012087495,"ENSG00000107819","A0A1P0AYU5,Sideroflexin","NP_112233.2,sideroflexin-3","-","IPR004686,Tricarboxylate/iron carrier","-","GO:0055085,biological_process,transmembrane transport;GO:0031966,cellular_component,mitochondrial membrane;GO:0006811,biological_process,ion transport;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0034220,biological_process,ion transmembrane transport;GO:0015075,molecular_function,ion transmembrane transporter activity;GO:0016021,cellular_component,integral component of membrane","-"]
["CRYBB2P1",2.619995387,1.222054807,1.096896767,3.714635671,0.005999808,0.012087495,"ENSG00000100058","A0A1B0GTR1,Propionyl-CoA carboxylase alpha chain, mitochondrial","-","PF00289,Biotin carboxylase, N-terminal domain","IPR005481,Biotin carboxylase-like, N-terminal domain;IPR016185,Pre-ATP-grasp domain superfamily;IPR011764,Biotin carboxylation domain","-","-","-"]
["PTRF",26.92207499,12.58268715,1.09680072,6.256713367,{"v":9.62e-06,"d":"9.62E-06"},{"v":3.67e-05,"d":"3.67E-05"},"ENSG00000177469","G1RLB4,Caveolae associated protein 1","XP_012359195.1,polymerase I and transcript release factor","PF15237,PTRF/SDPR family","IPR033297,Caveolae-associated protein 1;IPR026752,Cavin family","ENOG410IV8W,-;ENOG410XT47,-","GO:0045121,cellular_component,membrane raft;GO:0005901,cellular_component,caveola;GO:0005737,cellular_component,cytoplasm;GO:2000147,biological_process,positive regulation of cell motility;GO:0009303,biological_process,rRNA transcription;GO:0006363,biological_process,termination of RNA polymerase I transcription;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005886,cellular_component,plasma membrane;GO:0005739,cellular_component,mitochondrion;GO:0006361,biological_process,transcription initiation from RNA polymerase I promoter;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0042134,molecular_function,rRNA primary transcript binding","-"]
["MAK16",18.22847174,8.519520033,1.096709304,6.036912382,{"v":1.42E-5,"d":"1.42E-05"},{"v":5.22e-05,"d":"5.22E-05"},"ENSG00000198042","H2PQ12,Protein MAK16 homolog","XP_002819029.1,protein MAK16 homolog","PF01778,Ribosomal L28e protein family;PF04874,Mak16 protein C-terminal region","IPR029004,Ribosomal L28e/Mak16;IPR006958,Mak16 protein","KOG3064,RNA-binding nuclear protein (MAK16) containing a distinct C4 Zn-finger;COG5129,Nuclear protein with HMG-like acidic region","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus","-"]
["CEP57",8.393535624,3.922178965,1.096674331,5.477768157,{"v":6.54e-05,"d":"6.54E-05"},0.000206208,"ENSG00000166037","H2Q4L1,Centrosomal protein 57kDa","XP_001145458.1,centrosomal protein of 57 kDa isoform X1","PF06657,Centrosome microtubule-binding domain of Cep57;PF14073,Centrosome localisation domain of Cep57","IPR025913,Cep57 centrosome localisation domain;IPR010597,Centrosomal protein 57kDa;IPR024957,Cep57 centrosome microtubule-binding domain","ENOG410XPJC,-;ENOG410IESE,-","GO:0007286,biological_process,spermatid development;GO:0005794,cellular_component,Golgi apparatus;GO:0005874,cellular_component,microtubule;GO:0000060,biological_process,protein import into nucleus, translocation;GO:0008543,biological_process,fibroblast growth factor receptor signaling pathway;GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0008017,molecular_function,microtubule binding;GO:0043015,molecular_function,gamma-tubulin binding;GO:0017134,molecular_function,fibroblast growth factor binding;GO:0051260,biological_process,protein homooligomerization;GO:0005813,cellular_component,centrosome;GO:0000070,biological_process,mitotic sister chromatid segregation;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0034453,biological_process,microtubule anchoring","-"]
["C16orf72",7.284604142,3.405635807,1.096437551,6.421364811,{"v":6.25e-06,"d":"6.25E-06"},{"v":2.48E-5,"d":"2.48E-05"},"ENSG00000182831","A0A0D9R8I5,Chromosome 16 open reading frame 72","XP_007983526.1,-","PF15251,omain of unknown function (DUF4588)","IPR029196,Protein of unknown function DUF4588","-","-","-"]
["MSLN",11.78024939,5.503721929,1.096016116,4.519023353,0.000847301,0.002081138,"ENSG00000102854","H2QA86,Uncharacterized protein","-","PF06060,Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)","IPR026664,Stereocilin-related;IPR010335,Mesothelin","ENOG410IIJH,-;ENOG4111HFW,-","GO:0007160,biological_process,cell-matrix adhesion;GO:0009986,cellular_component,cell surface","-"]
["RP11-98D18.3",42.27039235,19.72842732,1.095869377,3.655949085,0.006559978,0.013083372,"ENSG00000249602","A0A0U1RRA2,Ornithine decarboxylase antizyme 3","-","-","IPR038581,Ornithine decarboxylase antizyme superfamily;IPR002993,Ornithine decarboxylase antizyme;IPR016181,Acyl-CoA N-acyltransferase;IPR029913,Ornithine decarboxylase antizyme 3","-","GO:0007283,biological_process,spermatogenesis;GO:0008073,molecular_function,ornithine decarboxylase inhibitor activity;GO:0043086,biological_process,negative regulation of catalytic activity","-"]
["SARS2",4.997613704,2.332485062,1.095869377,3.655949085,0.006559978,0.013083372,"ENSG00000104835","G3QJ75,Seryl-tRNA synthetase 2, mitochondrial","XP_004060735.1,serine--tRNA ligase, mitochondrial isoform X3","PF00587,tRNA synthetase class II core domain (G, H, P, S and T)","IPR002317,Serine-tRNA ligase, type1;IPR006195,Aminoacyl-tRNA synthetase, class II;IPR033729,Serine-tRNA ligase catalytic core domain;IPR002314,Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)","-","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0006434,biological_process,seryl-tRNA aminoacylation;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0004828,molecular_function,serine-tRNA ligase activity;GO:0005739,cellular_component,mitochondrion;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["CENPBD1P1",3.24960553,1.516655109,1.095869377,3.655949085,0.006559978,0.013083372,"ENSG00000213753","U6CX75,CENPB DNA-binding domain-containing protein 1","-","PF03221,Tc5 transposase DNA-binding domain;PF04218,CENP-B N-terminal DNA-binding domain","IPR006600,HTH CenpB-type DNA-binding domain;IPR009057,Homeobox-like domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR007889,DNA binding HTH domain, Psq-type","-","GO:0003677,molecular_function,DNA binding","-"]
["DEK",257.2802537,120.3661635,1.095860505,9.687082193,{"v":1.93e-07,"d":"1.93E-07"},{"v":1.06E-6,"d":"1.06E-06"},"ENSG00000124795","H2QSC7,DEK oncogene","XP_003311080.1,protein DEK;XP_009448846.1,-","PF08766,K C terminal domain","IPR036361,SAP domain superfamily;IPR014876,DEK, C-terminal;IPR003034,SAP domain","ENOG410XTJA,-;KOG2266,Chromatin-associated protein Dek and related proteins, contains SAP DNA binding domain","GO:2000779,biological_process,regulation of double-strand break repair;GO:0043292,cellular_component,contractile fiber;GO:0042393,molecular_function,histone binding;GO:0006338,biological_process,chromatin remodeling;GO:2001032,biological_process,regulation of double-strand break repair via nonhomologous end joining;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["CHTF8",16.77593104,7.845326353,1.095492389,5.4087335,{"v":7.34e-05,"d":"7.34E-05"},0.000229288,"ENSG00000168802","K7BPH9,CTF8, chromosome transmission fidelity factor 8 homolog","XP_016785561.1,-;XP_016785560.1,-;XP_016785556.1,chromosome transmission fidelity protein 8 homolog isoform X1;XP_016785559.1,-;XP_016785557.1,-;XP_016785558.1,-","-","-","-","-","-"]
["DEF6",22.2997936,10.42858116,1.095492389,5.4087335,{"v":7.34e-05,"d":"7.34E-05"},0.000229288,"ENSG00000023892","G3S3M7,DEF6, guanine nucleotide exchange factor","XP_004043914.1,-","PF00169,PH domain","IPR011992,EF-hand domain pair;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","-","GO:0005829,cellular_component,cytosol;GO:0005654,cellular_component,nucleoplasm","-"]
["IVD",4.50712659,2.106515336,1.095431155,4.485830276,0.000894278,0.00217692,"ENSG00000128928","A0A0A0MT83,Isovaleryl-CoA dehydrogenase, mitochondrial","NP_002216.2,isovaleryl-CoA dehydrogenase, mitochondrial isoform 1 precursor","PF00441,Acyl-CoA dehydrogenase, C-terminal domain;PF02771,Acyl-CoA dehydrogenase, N-terminal domain;PF02770,Acyl-CoA dehydrogenase, middle domain","IPR036250,Acyl-CoA dehydrogenase-like, C-terminal;IPR009100,Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily;IPR013786,Acyl-CoA dehydrogenase/oxidase, N-terminal;IPR037069,Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily;IPR009075,Acyl-CoA dehydrogenase/oxidase C-terminal;IPR034183,Isovaleryl-CoA dehydrogenase;IPR006091,Acyl-CoA oxidase/dehydrogenase, central domain;IPR006089,Acyl-CoA dehydrogenase, conserved site","KOG0141,Isovaleryl-CoA dehydrogenase;ENOG410XNMY,-","GO:0005739,cellular_component,mitochondrion;GO:0016627,molecular_function,oxidoreductase activity, acting on the CH-CH group of donors;GO:0003995,molecular_function,acyl-CoA dehydrogenase activity;GO:0008470,molecular_function,isovaleryl-CoA dehydrogenase activity;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0031966,cellular_component,mitochondrial membrane;GO:0016491,molecular_function,oxidoreductase activity;GO:0005759,cellular_component,mitochondrial matrix;GO:0006552,biological_process,leucine catabolic process;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process;GO:0005654,cellular_component,nucleoplasm","K00253,ko00280,Valine, leucine and isoleucine degradation"]
["MIEF2",7.418759893,3.467338043,1.095431155,4.485830276,0.000894278,0.00217692,"ENSG00000177427","G3QKQ0,Mitochondrial elongation factor 2","-","PF03281,Mab-21 protein","IPR024810,Mab-21 domain","-","GO:0005741,cellular_component,mitochondrial outer membrane;GO:0090314,biological_process,positive regulation of protein targeting to membrane;GO:0090141,biological_process,positive regulation of mitochondrial fission;GO:0007005,biological_process,mitochondrion organization;GO:0032464,biological_process,positive regulation of protein homooligomerization;GO:0005739,cellular_component,mitochondrion","-"]
["AHSA2",3.42790236,1.602744124,1.094817477,4.451851842,0.000841501,0.002067206,"ENSG00000173209","B8ZZA7,Activator of 90 kDa heat shock protein ATPase homolog 2","-","-","IPR023393,START-like domain superfamily","-","-","-"]
["TARDBP",22.02109402,10.30863416,1.094611094,6.629268767,{"v":4.72e-06,"d":"4.72E-06"},{"v":1.93e-05,"d":"1.93E-05"},"ENSG00000120948","H2PY00,TAR DNA binding protein","XP_016809429.1,-;XP_514380.2,-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)","IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily","ENOG410IFJS,-;ENOG410ZYQJ,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["DDX19B",17.32902431,8.115503284,1.09371901,5.867259701,{"v":2.46e-05,"d":"2.46E-05"},{"v":8.57e-05,"d":"8.57E-05"},"ENSG00000157349","H3BQK0,ATP-dependent RNA helicase DDX19B","XP_011521136.1,ATP-dependent RNA helicase DDX19B isoform X3","PF00271,Helicase conserved C-terminal domain;PF00270,AD/DEAH box helicase","IPR011545,DEAD/DEAH box helicase domain;IPR014014,RNA helicase, DEAD-box type, Q motif;IPR001650,Helicase, C-terminal;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0332,ATP-dependent RNA helicase;ENOG410XRGX,-","GO:0003676,molecular_function,nucleic acid binding;GO:0005524,molecular_function,ATP binding","-"]
["PAN2",2.020105517,0.944145492,1.093519771,3.530814262,9.865202E-3,0.018832822,"ENSG00000135473","G3R165,PAN2-PAN3 deadenylation complex catalytic subunit PAN2","XP_018893751.1,PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X6","PF13423,Ubiquitin carboxyl-terminal hydrolase;PF00929,xonuclease","IPR036322,WD40-repeat-containing domain superfamily;IPR028881,PAN2 domain;IPR028889,Ubiquitin specific protease domain;IPR030843,PAN2-PAN3 deadenylation complex catalytic subunit PAN2;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR036397,Ribonuclease H superfamily;IPR013520,Exonuclease, RNase T/DNA polymerase III;IPR012337,Ribonuclease H-like superfamily","-","GO:0010606,biological_process,positive regulation of cytoplasmic mRNA processing body assembly;GO:0004535,molecular_function,poly(A)-specific ribonuclease activity;GO:0004518,molecular_function,nuclease activity;GO:0005737,cellular_component,cytoplasm;GO:0004527,molecular_function,exonuclease activity;GO:0090503,biological_process,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0005634,cellular_component,nucleus;GO:0000288,biological_process,nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0046872,molecular_function,metal ion binding;GO:0000932,cellular_component,P-body;GO:0016787,molecular_function,hydrolase activity;GO:0000175,molecular_function,3'-5'-exoribonuclease activity;GO:0003676,molecular_function,nucleic acid binding;GO:0000289,biological_process,nuclear-transcribed mRNA poly(A) tail shortening;GO:0031251,cellular_component,PAN complex;GO:0006397,biological_process,mRNA processing;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis","K12571,ko03018,RNA degradation"]
["RPAP1",2.089487512,0.976572856,1.093519771,3.530814262,9.865202E-3,0.018832822,"ENSG00000103932","H2Q983,RNA polymerase II associated protein 1","XP_016783465.1,-;XP_001150430.1,RNA polymerase II-associated protein 1 isoform X1;XP_009427131.1,-","PF08620,RPAP1-like, C-terminal;PF08621,RPAP1-like, N-terminal","IPR013930,RNA polymerase II-associated protein 1, N-terminal;IPR013929,RNA polymerase II-associated protein 1, C-terminal","KOG1894,Uncharacterized conserved protein;ENOG410XNVT,-","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus","-"]
["SYS1",2.406821809,1.124886766,1.093519771,3.530814262,9.865202E-3,0.018832822,"ENSG00000204070","A0A0D9RPF8,SYS1, golgi trafficking protein","XP_008014245.1,-","PF09801,Integral membrane protein S linking to the trans Golgi network","IPR019185,Integral membrane protein SYS1-related;IPR016973,Integral membrane protein SYS1","-","GO:0000139,cellular_component,Golgi membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CCNE2",6.210579192,2.906271175,1.093495075,4.381383278,1.120179E-3,0.002680601,"ENSG00000175305","A0A024R9B0,Cyclin E2, isoform CRA_e","XP_016869448.1,-;XP_016869446.1,-;XP_016869447.1,-;NP_477097.1,G1/S-specific cyclin-E2","PF02984,Cyclin, C-terminal domain;PF00134,Cyclin, N-terminal domain","IPR004367,Cyclin, C-terminal domain;IPR013763,Cyclin-like;IPR028858,Cyclin E;IPR036915,Cyclin-like superfamily;IPR006671,Cyclin, N-terminal","ENOG410XS2J,-;KOG0655,G1/S-specific cyclin E","GO:0070192,biological_process,chromosome organization involved in meiotic cell cycle;GO:0019901,molecular_function,protein kinase binding;GO:0097135,cellular_component,cyclin E2-CDK2 complex;GO:0016538,molecular_function,cyclin-dependent protein serine/threonine kinase regulator activity;GO:0000082,biological_process,G1/S transition of mitotic cell cycle;GO:0006270,biological_process,DNA replication initiation;GO:0007129,biological_process,synapsis;GO:0045859,biological_process,regulation of protein kinase activity;GO:0051726,biological_process,regulation of cell cycle;GO:0000723,biological_process,telomere maintenance;GO:0005634,cellular_component,nucleus;GO:1903827,biological_process,regulation of cellular protein localization","K06626,ko04114,Oocyte meiosis;K06626,ko05200,Pathways in cancer;K06626,ko05206,MicroRNAs in cancer;K06626,ko04151,PI3K-Akt signaling pathway;K06626,ko04115,p53 signaling pathway;K06626,ko05162,Measles;K06626,ko04391,Hippo signaling pathway - fly;K06626,ko05203,Viral carcinogenesis;K06626,ko05161,Hepatitis B;K06626,ko05222,Small cell lung cancer;K06626,ko05215,Prostate cancer;K06626,ko04110,Cell cycle"]
["ERCC6",3.09292655,1.448712131,1.09311403,5.279336691,1.14418E-4,0.000341872,"ENSG00000225830","A0JP10,Excision repair cross-complementing rodent repair deficiency, complementation group 6","-","PF00271,Helicase conserved C-terminal domain;PF00176,SNF2 family N-terminal domain","IPR001650,Helicase, C-terminal;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG0387,Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain);ENOG410XP4Z,-","GO:0005524,molecular_function,ATP binding","-"]
["CALCOCO2",24.07942191,11.28518046,1.093090769,7.211496055,{"v":1.72E-6,"d":"1.72E-06"},{"v":7.76e-06,"d":"7.76E-06"},"ENSG00000136436","G3SGR7,Calcium binding and coiled-coil domain 2","-","PF07888,Calcium binding and coiled-coil domain (CALCOCO1) like","IPR012852,Calcium binding and coiled-coil domain-like","-","-","-"]
["FAM122B",6.038950107,2.827250434,1.092781314,4.344807888,1.41697E-3,3.299565E-3,"ENSG00000156504","K7CMQ9,Family with sequence similarity 122B","XP_016799652.1,-","-","IPR026716,FAM122","ENOG410ZUHK,-;ENOG410IF6F,-","-","-"]
["SKIL",9.52037591,4.463161807,1.092193506,5.78795617,{"v":2.77e-05,"d":"2.77E-05"},{"v":9.53e-05,"d":"9.53E-05"},"ENSG00000136603","H2QNQ5,SKI-like oncogene","XP_001163447.1,ski-like protein;XP_016797783.1,-;XP_016797784.1,-","PF02437,SKI/SNO/DAC family;PF08782,c-SKI Smad4 binding domain","IPR037000,Ski-like, DNA-binding domain superfamily;IPR023216,Transcription regulator SKI/SnoN;IPR014890,c-SKI SMAD4-binding domain;IPR003380,SKI/SNO/DAC domain;IPR010919,SAND-like domain superfamily;IPR028373,Ski-related oncogene Sno;IPR009061,Putative DNA-binding domain superfamily","ENOG410Y8AU,-;ENOG410IFDK,-","GO:0048666,biological_process,neuron development;GO:0030514,biological_process,negative regulation of BMP signaling pathway;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0046332,molecular_function,SMAD binding;GO:0030512,biological_process,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0045596,biological_process,negative regulation of cell differentiation","K18499,ko04550,Signaling pathways regulating pluripotency of stem cells"]
["ZSWIM4",2.972660423,1.390466561,1.092167935,3.463882433,0.009571636,0.018355141,"ENSG00000132003","K7DLI1,Zinc finger, SWIM-type containing 4","-","-","IPR007527,Zinc finger, SWIM-type","KOG3615,Uncharacterized conserved protein;ENOG410XPZG,-","GO:0008270,molecular_function,zinc ion binding","-"]
["HACD3",12.11224075,5.678822565,1.09214801,5.999503719,{"v":1.9e-05,"d":"1.90E-05"},{"v":6.79e-05,"d":"6.79E-05"},"ENSG00000074696","H3BS72,Very-long-chain","-","PF04387,Protein tyrosine phosphatase-like protein, PTPLA","IPR007482,Protein-tyrosine phosphatase-like, PTPLA;IPR007052,CS domain;IPR008978,HSP20-like chaperone","-","GO:0006631,biological_process,fatty acid metabolic process;GO:0006629,biological_process,lipid metabolic process;GO:0102343,molecular_function,3-hydroxy-arachidoyl-CoA dehydratase activity;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0102158,molecular_function,very-long-chain 3-hydroxyacyl-CoA dehydratase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0006633,biological_process,fatty acid biosynthetic process;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0031965,cellular_component,nuclear membrane;GO:0102344,molecular_function,3-hydroxy-behenoyl-CoA dehydratase activity;GO:0102345,molecular_function,3-hydroxy-lignoceroyl-CoA dehydratase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016829,molecular_function,lyase activity","-"]
["VPS51",5.306100007,2.485352084,1.092028698,4.307275993,0.001507252,0.003497145,"ENSG00000149823","H2Q419,Chromosome 11 open reading frame 2","-","PF08700,Vps51/Vps67","IPR014812,Vacuolar protein sorting-associated protein 51;IPR016159,Cullin repeat-like-containing domain superfamily","KOG2346,Uncharacterized conserved protein;ENOG410XPIF,-","GO:0000938,cellular_component,GARP complex;GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0048193,biological_process,Golgi vesicle transport;GO:1990745,cellular_component,EARP complex;GO:0007030,biological_process,Golgi organization;GO:0005829,cellular_component,cytosol;GO:0032456,biological_process,endocytic recycling;GO:0016021,cellular_component,integral component of membrane","-"]
["HMOX2",19.34489451,9.070567291,1.091922153,5.774303969,{"v":2.81e-05,"d":"2.81E-05"},{"v":9.66e-05,"d":"9.66E-05"},"ENSG00000103415","A0A087WT44,Heme oxygenase 2","NP_001273196.1,heme oxygenase 2 isoform a;XP_011520775.1,-","PF01126,Heme oxygenase","IPR018207,Haem oxygenase conserved site;IPR002051,Haem oxygenase;IPR016084,Haem oxygenase-like, multi-helical;IPR016053,Haem oxygenase-like","COG5398,Heme oxygenase;KOG4480,Heme oxygenase","GO:0004392,molecular_function,heme oxygenase (decyclizing) activity;GO:0006979,biological_process,response to oxidative stress;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0006788,biological_process,heme oxidation;GO:0016021,cellular_component,integral component of membrane","-"]
["SNX3",76.96183862,36.11057511,1.091325744,6.714204617,{"v":4.21e-06,"d":"4.21E-06"},{"v":1.74e-05,"d":"1.74E-05"},"ENSG00000112335","A0A1U7QG80,sorting nexin-3","XP_005073275.1,-","-","IPR036871,PX domain superfamily;IPR001683,Phox homologous domain","-","GO:0035091,molecular_function,phosphatidylinositol binding","-"]
["PRC1-AS1",13.99153719,6.55691163,1.091233967,4.268736032,0.001426132,0.003319459,"ENSG00000258725","G3V3N7,Protein regulator of cytokinesis 1","-","PF03999,Microtubule associated protein (MAP65/ASE1 family)","IPR032921,Protein regulator of cytokinesis 1;IPR007145,Microtubule-associated protein, MAP65/Ase1/PRC1","KOG4302,Microtubule-associated protein essential for anaphase spindle elongation;ENOG410YZBK,-","GO:0000910,biological_process,cytokinesis;GO:0005856,cellular_component,cytoskeleton;GO:0001578,biological_process,microtubule bundle formation;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0008017,molecular_function,microtubule binding","-"]
["SYNGR2",17.48601953,8.203650319,1.091075877,5.732553637,{"v":3.59e-05,"d":"3.59E-05"},1.20566E-4,"ENSG00000108639","H2NUW0,Synaptogyrin","-","PF01284,Membrane-associating domain","IPR016579,Synaptogyrin;IPR008253,Marvel domain","ENOG410ITZZ,-;ENOG4111G0F,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["HM13",5.936503632,2.785139283,1.090918392,5.473872024,{"v":7.32e-05,"d":"7.32E-05"},0.000228742,"ENSG00000101294","H2QK51,Histocompatibility minor 13","XP_016793119.1,-;XP_001152482.1,-","PF04258,Signal peptide peptidase","IPR007369,Peptidase A22B, signal peptide peptidase;IPR006639,Presenilin/signal peptide peptidase","KOG2443,Uncharacterized conserved protein;ENOG410XTES,-","GO:0006508,biological_process,proteolysis;GO:0071458,cellular_component,integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0030660,cellular_component,Golgi-associated vesicle membrane;GO:0004190,molecular_function,aspartic-type endopeptidase activity;GO:0071556,cellular_component,integral component of lumenal side of endoplasmic reticulum membrane;GO:0005765,cellular_component,lysosomal membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["HEATR5B",1.620493314,0.758665057,1.090673109,3.393658987,0.013367305,0.024752047,"ENSG00000008869","H2QHR2,HEAT repeat containing 5B","XP_515406.2,HEAT repeat-containing protein 5B isoform X1;XP_009440564.1,-","-","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","ENOG410XP05,-;KOG1822,Uncharacterized conserved protein","-","-"]
["SLC20A1",2.384394502,1.116300064,1.090673109,3.393658987,0.013367305,0.024752047,"ENSG00000144136","A7LNJ1,Phosphate transporter","NP_005406.3,sodium-dependent phosphate transporter 1","PF01384,Phosphate transporter family","IPR001204,Phosphate transporter","KOG2493,Na+/Pi symporter;COG0306,Phosphate/sulphate permeases","GO:0006814,biological_process,sodium ion transport;GO:0055085,biological_process,transmembrane transport;GO:0005315,molecular_function,inorganic phosphate transmembrane transporter activity;GO:0005316,molecular_function,high-affinity inorganic phosphate:sodium symporter activity;GO:0035725,biological_process,sodium ion transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0006817,biological_process,phosphate ion transport;GO:0016021,cellular_component,integral component of membrane","-"]
["FNBP1L",21.91120692,10.28539962,1.090629471,6.557549048,{"v":5.27e-06,"d":"5.27E-06"},{"v":2.13e-05,"d":"2.13E-05"},"ENSG00000137942","S4R347,Formin-binding protein 1-like","-","PF00018,SH3 domain;PF00611,es/CIP4, and EFC/F-BAR homology domain","IPR035493,FNBP1L, SH3 domain;IPR031160,F-BAR domain;IPR001060,FCH domain;IPR027267,AH/BAR domain superfamily;IPR030116,Formin-binding protein 1-like;IPR035494,FNBP1L, F-BAR domain;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain","ENOG410INNW,-;ENOG410XS31,-","GO:0005829,cellular_component,cytosol;GO:0006897,biological_process,endocytosis","-"]
["NOP2",12.20991999,5.732537337,1.089828447,5.422265362,{"v":7.17e-05,"d":"7.17E-05"},2.24563E-4,"ENSG00000111641","F6ZSG5,NOP2 nucleolar protein","-","PF08062,P120R (NUC006) repeat;PF17125,N-terminal domain of 16S rRNA methyltransferase RsmF;PF01189,16S rRNA methyltransferase RsmB/F","IPR012586,P120R repeat;IPR023267,RNA (C5-cytosine) methyltransferase;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR023273,RNA (C5-cytosine) methyltransferase, NOP2;IPR018314,Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site;IPR001678,SAM-dependent methyltransferase RsmB/NOP2-type;IPR031341,Ribosomal RNA small subunit methyltransferase F, N-terminal;IPR011023,Nop2p","COG0144,tRNA and rRNA cytosine-C5-methylases;KOG1122,tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2)","GO:0008284,biological_process,positive regulation of cell proliferation;GO:0005730,cellular_component,nucleolus;GO:0000027,biological_process,ribosomal large subunit assembly;GO:0016740,molecular_function,transferase activity;GO:0003723,molecular_function,RNA binding;GO:0008757,molecular_function,S-adenosylmethionine-dependent methyltransferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:1901796,biological_process,regulation of signal transduction by p53 class mediator;GO:0006364,biological_process,rRNA processing","-"]
["ATP6V0D1",2.891623786,1.356619232,1.089503174,4.188403707,0.001952029,0.00442513,"ENSG00000159720","F5GYQ1,V-type proton ATPase subunit","-","PF01992,ATP synthase (C/AC39) subunit","IPR002843,ATPase, V0 complex,  c/d subunit;IPR036079,V-type ATP synthase subunit C-like;IPR016727,ATPase, V0 complex, subunit d","-","GO:0015991,biological_process,ATP hydrolysis coupled proton transport;GO:0006811,biological_process,ion transport;GO:0033179,cellular_component,proton-transporting V-type ATPase, V0 domain;GO:0015078,molecular_function,proton transmembrane transporter activity","-"]
["SWAP70",13.87110723,6.516811216,1.089283252,6.212259646,{"v":1.08E-5,"d":"1.08E-05"},{"v":4.09e-05,"d":"4.09E-05"},"ENSG00000133789","G3R053,SWAP switching B-cell complex subunit 70","XP_004050730.1,switch-associated protein 70","PF00169,PH domain","IPR002048,EF-hand domain;IPR011992,EF-hand domain pair;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","-","GO:0032233,biological_process,positive regulation of actin filament bundle assembly;GO:0003677,molecular_function,DNA binding;GO:0045190,biological_process,isotype switching;GO:0005737,cellular_component,cytoplasm;GO:0008064,biological_process,regulation of actin polymerization or depolymerization;GO:0005509,molecular_function,calcium ion binding;GO:0005524,molecular_function,ATP binding;GO:0033633,biological_process,negative regulation of cell-cell adhesion mediated by integrin;GO:0030835,biological_process,negative regulation of actin filament depolymerization;GO:0051017,biological_process,actin filament bundle assembly;GO:0045296,molecular_function,cadherin binding;GO:0032880,biological_process,regulation of protein localization;GO:0007204,biological_process,positive regulation of cytosolic calcium ion concentration;GO:0016444,biological_process,somatic cell DNA recombination;GO:0005634,cellular_component,nucleus;GO:1902309,biological_process,negative regulation of peptidyl-serine dephosphorylation;GO:0060754,biological_process,positive regulation of mast cell chemotaxis","-"]
["BRD8",20.18714548,9.486707749,1.08906388,6.719701023,{"v":4.19e-06,"d":"4.19E-06"},{"v":1.74e-05,"d":"1.74E-05"},"ENSG00000112983","H2QRK0,Uncharacterized protein","XP_517951.2,bromodomain-containing protein 8 isoform X6","PF00439,Bromodomain","IPR036427,Bromodomain-like superfamily;IPR037966,Brd8, Bromo domain;IPR001487,Bromodomain;IPR038002,Bromodomain-containing protein 8","ENOG410IF07,-;ENOG410Y97J,-","GO:0043967,biological_process,histone H4 acetylation;GO:0043968,biological_process,histone H2A acetylation;GO:0035267,cellular_component,NuA4 histone acetyltransferase complex;GO:0000812,cellular_component,Swr1 complex;GO:0005739,cellular_component,mitochondrion;GO:0005654,cellular_component,nucleoplasm","-"]
["DERL1",4.829015806,2.267406978,1.089047736,4.696805456,0.000509216,0.001316859,"ENSG00000136986","G1QZD6,Derlin","XP_003256215.1,-","PF04511,er1-like family","IPR007599,Derlin","KOG0858,Predicted membrane protein;COG5291,Predicted membrane protein","GO:0005770,cellular_component,late endosome;GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0051260,biological_process,protein homooligomerization;GO:0030970,biological_process,retrograde protein transport, ER to cytosol;GO:0005769,cellular_component,early endosome;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0036503,biological_process,ERAD pathway;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0032092,biological_process,positive regulation of protein binding;GO:0002020,molecular_function,protease binding;GO:0006986,biological_process,response to unfolded protein;GO:0051117,molecular_function,ATPase binding;GO:0016021,cellular_component,integral component of membrane;GO:0036502,cellular_component,Derlin-1-VIMP complex;GO:0005785,cellular_component,signal recognition particle receptor complex;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0016020,cellular_component,membrane;GO:0048500,cellular_component,signal recognition particle;GO:0042288,molecular_function,MHC class I protein binding;GO:0034620,biological_process,cellular response to unfolded protein;GO:1990381,molecular_function,ubiquitin-specific protease binding;GO:0036513,cellular_component,Derlin-1 retrotranslocation complex;GO:0071712,biological_process,ER-associated misfolded protein catabolic process;GO:0031648,biological_process,protein destabilization;GO:0031398,biological_process,positive regulation of protein ubiquitination","K11519,ko04141,Protein processing in endoplasmic reticulum;K11519,ko05014,Amyotrophic lateral sclerosis (ALS)"]
["MTPAP",1.498795725,0.702386806,1.089011338,3.319801551,0.014866261,0.027205224,"ENSG00000107951","K7B1T3,Mitochondrial poly","XP_001136690.1,poly(A) RNA polymerase, mitochondrial","PF03828,Cid1 family poly A polymerase","IPR002058,PAP/25A-associated","COG5260,DNA polymerase sigma;KOG2277,S-M checkpoint control protein CID1 and related nucleotidyltransferases","GO:0042803,molecular_function,protein homodimerization activity;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0071044,biological_process,histone mRNA catabolic process;GO:0005739,cellular_component,mitochondrion;GO:0006378,biological_process,mRNA polyadenylation;GO:0002134,molecular_function,UTP binding;GO:0004652,molecular_function,polynucleotide adenylyltransferase activity;GO:0042802,molecular_function,identical protein binding;GO:0005524,molecular_function,ATP binding;GO:0030145,molecular_function,manganese ion binding;GO:0000287,molecular_function,magnesium ion binding","-"]
["DNA2",2.585861455,1.211822891,1.089011338,3.319801551,0.014866261,0.027205224,"ENSG00000138346","K7DGY2,DNA replication helicase 2 homolog","-","PF13087,AAA domain;PF13086,AAA domain;PF08696,NA replication factor Dna2","IPR026851,Dna2;IPR014808,DNA replication factor Dna2, N-terminal;IPR027417,P-loop containing nucleoside triphosphate hydrolase","KOG1805,DNA replication helicase;COG1112,Superfamily I DNA and RNA helicases and helicase subunits","GO:0017108,molecular_function,5'-flap endonuclease activity;GO:0004386,molecular_function,helicase activity;GO:0043142,molecular_function,single-stranded DNA-dependent ATPase activity;GO:0033567,biological_process,DNA replication, Okazaki fragment processing","-"]
["ENDOD1",2.685169127,1.258361854,1.089011338,3.319801551,0.014866261,0.027205224,"ENSG00000149218","K6ZY85,Endonuclease domain containing 1","XP_009422296.1,endonuclease domain-containing 1 protein isoform X1","PF01223,NA/RNA non-specific endonuclease","IPR020821,Extracellular Endonuclease, subunit A;IPR001604,DNA/RNA non-specific endonuclease","ENOG410J1DZ,-;ENOG4111RBI,-","GO:0016787,molecular_function,hydrolase activity;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0004519,molecular_function,endonuclease activity","-"]
["ZNF277",3.135373119,1.469342803,1.089011338,3.319801551,0.014866261,0.027205224,"ENSG00000198839","A0A0D9RFF2,Zinc finger protein 277","XP_007980812.1,zinc finger protein 277 isoform X1","PF12756,C2H2 type zinc-finger (2 copies)","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:2000772,biological_process,regulation of cellular senescence;GO:0003676,molecular_function,nucleic acid binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0070301,biological_process,cellular response to hydrogen peroxide","-"]
["RP11-618P17.4",45.83419642,21.5302469,1.088805377,5.071632916,2.14448E-4,0.000603447,"ENSG00000266953","K7ESF4,Uncharacterized protein","-","PF00342,Phosphoglucose isomerase","IPR001672,Phosphoglucose isomerase (PGI);IPR035482,Phosphoglucose isomerase, SIS domain 2","KOG2061,Uncharacterized MYND Zn-finger protein;KOG2446,Glucose-6-phosphate isomerase;COG0166,Glucose-6-phosphate isomerase","GO:0006094,biological_process,gluconeogenesis;GO:0004347,molecular_function,glucose-6-phosphate isomerase activity;GO:0006096,biological_process,glycolytic process","-"]
["SUSD6",3.950880633,1.854698746,1.088558479,4.146484707,2.088739E-3,0.004694048,"ENSG00000100647","G3QDH7,Sushi domain containing 6","XP_018865651.1,sushi domain-containing protein 6","PF00084,Sushi repeat (SCR repeat)","IPR000436,Sushi/SCR/CCP domain;IPR035976,Sushi/SCR/CCP superfamily","-","GO:0008219,biological_process,cell death;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PRKCZ",4.384740765,2.059696878,1.088388002,4.667513269,0.00062406,0.001576857,"ENSG00000067606","G3RB70,Protein kinase C","XP_018865576.1,-","PF00130,Phorbol esters/diacylglycerol binding domain (C1 domain);PF00433,Protein kinase C terminal domain;PF00069,Protein kinase domain;PF00564,PB1 domain","IPR034662,Atypical Protein Kinase C zeta, catalytic domain;IPR012233,Protein kinase C;IPR000270,PB1 domain;IPR020454,Diacylglycerol/phorbol-ester binding;IPR017892,Protein kinase, C-terminal;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR034877,Protein kinase C, PB1 domain;IPR000719,Protein kinase domain","-","GO:0050732,biological_process,negative regulation of peptidyl-tyrosine phosphorylation;GO:0032753,biological_process,positive regulation of interleukin-4 production;GO:0005815,cellular_component,microtubule organizing center;GO:0005886,cellular_component,plasma membrane;GO:0046872,molecular_function,metal ion binding;GO:0016363,cellular_component,nuclear matrix;GO:0005635,cellular_component,nuclear envelope;GO:0005524,molecular_function,ATP binding;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0016301,molecular_function,kinase activity;GO:0005923,cellular_component,bicellular tight junction;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0031982,cellular_component,vesicle;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0005938,cellular_component,cell cortex;GO:0005634,cellular_component,nucleus;GO:0045179,cellular_component,apical cortex;GO:0046627,biological_process,negative regulation of insulin receptor signaling pathway;GO:0005829,cellular_component,cytosol;GO:1990138,biological_process,neuron projection extension;GO:0016310,biological_process,phosphorylation;GO:2000664,biological_process,positive regulation of interleukin-5 secretion;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:2000553,biological_process,positive regulation of T-helper 2 cell cytokine production;GO:0016740,molecular_function,transferase activity;GO:0045630,biological_process,positive regulation of T-helper 2 cell differentiation;GO:0016324,cellular_component,apical plasma membrane;GO:0043203,cellular_component,axon hillock;GO:2000667,biological_process,positive regulation of interleukin-13 secretion;GO:2001181,biological_process,positive regulation of interleukin-10 secretion;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005911,cellular_component,cell-cell junction;GO:0031333,biological_process,negative regulation of protein complex assembly;GO:0004697,molecular_function,protein kinase C activity;GO:0072659,biological_process,protein localization to plasma membrane;GO:0035748,cellular_component,myelin sheath abaxonal region;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0004672,molecular_function,protein kinase activity","K18952,ko04015,Rap1 signaling pathway;K18952,ko04930,Type II diabetes mellitus;K18952,ko04144,Endocytosis;K18952,ko04071,Sphingolipid signaling pathway;K18952,ko04910,Insulin signaling pathway;K18952,ko04062,Chemokine signaling pathway;K18952,ko04933,AGE-RAGE signaling pathway in diabetic complications;K18952,ko04611,Platelet activation;K18952,ko04390,Hippo signaling pathway;K18952,ko04931,Insulin resistance;K18952,ko04530,Tight junction"]
["LRRC41",3.890527595,1.827544198,1.088388002,4.667513269,0.00062406,0.001576857,"ENSG00000132128","G3SCF0,Leucine rich repeat containing 41","XP_004025768.1,-","-","IPR026137,Leucine-rich repeat-containing  41;IPR032675,Leucine-rich repeat domain superfamily","-","GO:0005737,cellular_component,cytoplasm;GO:0042803,molecular_function,protein homodimerization activity;GO:0005634,cellular_component,nucleus","-"]
["HBS1L",3.0166574,1.417050668,1.088388002,4.667513269,0.00062406,0.001576857,"ENSG00000112339","D9YZV0,HBS1-like","NP_006611.1,HBS1-like protein isoform 1","PF08938,HBS1 N-terminus;PF00009,longation factor Tu GTP binding domain;PF03143,longation factor Tu C-terminal domain;PF03144,longation factor Tu domain 2","IPR000795,Transcription factor, GTP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR037189,HBS1-like protein, N-terminal domain superfamily;IPR004161,Translation elongation factor EFTu-like, domain 2;IPR004160,Translation elongation factor EFTu/EF1A, C-terminal;IPR009000,Translation protein, beta-barrel domain superfamily;IPR015033,HBS1-like protein, N-terminal;IPR009001,Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal","COG5256,Translation elongation factor EF-1alpha (GTPase);KOG0458,Elongation factor 1 alpha","GO:0005525,molecular_function,GTP binding;GO:0005515,molecular_function,protein binding;GO:0003924,molecular_function,GTPase activity","K14416,ko03015,mRNA surveillance pathway;K14416,ko05134,Legionellosis"]
["MRPL9",35.77628017,16.81716357,1.088206132,5.599512138,{"v":4.86e-05,"d":"4.86E-05"},1.58128E-4,"ENSG00000143436","G3QHN7,Mitochondrial ribosomal protein L9","XP_004026711.1,39S ribosomal protein L9, mitochondrial","PF01281,Ribosomal protein L9, N-terminal domain","IPR009027,Ribosomal protein L9/RNase H1, N-terminal;IPR020070,Ribosomal protein L9, N-terminal;IPR036935,Ribosomal protein L9, N-terminal domain superfamily;IPR000244,Ribosomal protein L9","-","GO:0003735,molecular_function,structural constituent of ribosome;GO:0005840,cellular_component,ribosome;GO:0005739,cellular_component,mitochondrion;GO:0005622,cellular_component,intracellular;GO:0005762,cellular_component,mitochondrial large ribosomal subunit;GO:0006412,biological_process,translation","K02939,ko03010,Ribosome"]
["CTTN",267.7022274,125.9446052,1.087809772,10.41848348,{"v":1.93e-07,"d":"1.93E-07"},{"v":1.06E-6,"d":"1.06E-06"},"ENSG00000085733","G3QKI9,Cortactin","-","PF00018,SH3 domain;PF02218,Repeat in HS1/Cortactin","IPR015503,Cortactin;IPR003134,Hs1/Cortactin;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain","-","GO:0030041,biological_process,actin filament polymerization","-"]
["FAM129A",3.914178219,1.839486612,1.087699935,4.637611561,0.000655358,1.651013E-3,"ENSG00000135842","A0A024R978,Chromosome 1 open reading frame 24, isoform CRA_a","NP_443198.1,protein Niban","-","IPR026088,Niban-like","ENOG41102BB,-;ENOG410IFR1,-","GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0001933,biological_process,negative regulation of protein phosphorylation;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0045727,biological_process,positive regulation of translation;GO:0001934,biological_process,positive regulation of protein phosphorylation","-"]
["NCAPG2",4.689396115,2.203803938,1.087699935,4.637611561,0.000655358,1.651013E-3,"ENSG00000146918","B3KRQ2,cDNA FLJ34689 fis, clone MESAN2000815, highly similar to Homo sapiens leucine zipper protein 5","NP_001268861.1,-","PF12422,Condensin II non structural maintenance of chromosomes subunit","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR024741,Condensin-2 complex subunit G2","ENOG410XSM3,-;KOG1949,Uncharacterized conserved protein","GO:0005634,cellular_component,nucleus","-"]
["NFKBIB",9.604670248,4.511716972,1.087554256,4.103303159,0.002705531,5.907748E-3,"ENSG00000104825","K7AVY5,Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta","XP_001168499.1,NF-kappa-B inhibitor beta isoform X2","PF12796,Ankyrin repeats (3 copies);PF13637,Ankyrin repeats (many copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","-","K02581,ko04062,Chemokine signaling pathway;K02581,ko04722,Neurotrophin signaling pathway;K02581,ko04662,B cell receptor signaling pathway;K02581,ko05145,Toxoplasmosis;K02581,ko05164,Influenza A;K02581,ko04621,NOD-like receptor signaling pathway;K02581,ko04622,RIG-I-like receptor signaling pathway;K02581,ko05162,Measles;K02581,ko04623,Cytosolic DNA-sensing pathway;K02581,ko05140,Leishmaniasis;K02581,ko05168,Herpes simplex infection;K02581,ko04920,Adipocytokine signaling pathway;K02581,ko04660,T cell receptor signaling pathway;K02581,ko05169,Epstein-Barr virus infection;K02581,ko05131,Shigellosis"]
["DEGS1",4.72087764,2.214822492,1.087153,3.241911272,0.021043513,0.036842173,"ENSG00000143753","A0A024R3P1,Degenerative spermatocyte homolog 1, lipid desaturase","NP_003667.1,sphingolipid delta(4)-desaturase DES1 isoform 1","PF00487,atty acid desaturase;PF08557,Sphingolipid Delta4-desaturase (DES)","IPR005804,Fatty acid desaturase domain;IPR011388,Sphingolipid delta4-desaturase;IPR013866,Sphingolipid delta4-desaturase, N-terminal","KOG2987,Fatty acid desaturase;ENOG410XQVT,-","GO:0006629,biological_process,lipid metabolic process;GO:0030148,biological_process,sphingolipid biosynthetic process;GO:0042284,molecular_function,sphingolipid delta-4 desaturase activity;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane","K04712,ko04071,Sphingolipid signaling pathway;K04712,ko00600,Sphingolipid metabolism"]
["PJA2",15.74874646,7.411210757,1.086776346,5.936793693,{"v":2.45e-05,"d":"2.45E-05"},{"v":8.53E-5,"d":"8.53E-05"},"ENSG00000198961","K7CRJ0,Praja ring finger 2","-","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR030639,E3 ubiquitin-protein ligase Praja-2","KOG0800,FOG: Predicted E3 ubiquitin ligase;ENOG41121N2,-","GO:0010738,biological_process,regulation of protein kinase A signaling;GO:0035329,biological_process,hippo signaling;GO:0005622,cellular_component,intracellular;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["BCR",4.159242193,1.957147061,1.086485355,5.274857611,0.000129292,0.00038178,"ENSG00000186716","K6ZU85,Breakpoint cluster region","XP_016795021.1,breakpoint cluster region protein isoform X2","PF09036,Bcr-Abl oncoprotein oligomerisation domain;PF00621,RhoGEF domain;PF00168,C2 domain;PF00620,RhoGAP domain","IPR001331,Guanine-nucleotide dissociation stimulator, CDC24, conserved site;IPR035899,Dbl homology (DH) domain superfamily;IPR001849,Pleckstrin homology domain;IPR036481,Bcr-Abl oncoprotein oligomerisation domain superfamily;IPR000198,Rho GTPase-activating protein domain;IPR000008,C2 domain;IPR015123,Bcr-Abl oncoprotein oligomerisation;IPR035892,C2 domain superfamily;IPR008936,Rho GTPase activation protein;IPR037769,Abr/Bcr;IPR000219,Dbl homology (DH) domain","KOG4269,Rac GTPase-activating protein BCR/ABR;ENOG410XPGZ,-","GO:0065002,biological_process,intracellular protein transmembrane transport;GO:0050766,biological_process,positive regulation of phagocytosis;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0002692,biological_process,negative regulation of cellular extravasation;GO:0005886,cellular_component,plasma membrane;GO:0005096,molecular_function,GTPase activator activity;GO:0030336,biological_process,negative regulation of cell migration;GO:0042472,biological_process,inner ear morphogenesis;GO:0051171,biological_process,regulation of nitrogen compound metabolic process;GO:0035556,biological_process,intracellular signal transduction;GO:0060216,biological_process,definitive hemopoiesis;GO:0048872,biological_process,homeostasis of number of cells;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0005829,cellular_component,cytosol;GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0050728,biological_process,negative regulation of inflammatory response;GO:0060313,biological_process,negative regulation of blood vessel remodeling;GO:0030036,biological_process,actin cytoskeleton organization;GO:0003014,biological_process,renal system process;GO:0060268,biological_process,negative regulation of respiratory burst;GO:0043114,biological_process,regulation of vascular permeability;GO:2000378,biological_process,negative regulation of reactive oxygen species metabolic process;GO:0007420,biological_process,brain development;GO:0050885,biological_process,neuromuscular process controlling balance;GO:0043314,biological_process,negative regulation of neutrophil degranulation;GO:0006468,biological_process,protein phosphorylation;GO:0007165,biological_process,signal transduction;GO:0032496,biological_process,response to lipopolysaccharide;GO:0005085,molecular_function,guanyl-nucleotide exchange factor activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0051726,biological_process,regulation of cell cycle;GO:0014069,cellular_component,postsynaptic density","-"]
["NDFIP2",12.53412069,5.900790669,1.08595953,5.503460558,{"v":6.26e-05,"d":"6.26E-05"},1.98765E-4,"ENSG00000102471","H2Q7P1,Uncharacterized protein","-","-","IPR019325,NEDD4/Bsd2","KOG4812,Golgi-associated protein/Nedd4 WW domain-binding protein;ENOG4111M6U,-","GO:0004871,molecular_function,signal transducer activity;GO:0032410,biological_process,negative regulation of transporter activity;GO:0005794,cellular_component,Golgi apparatus;GO:0030001,biological_process,metal ion transport;GO:0051224,biological_process,negative regulation of protein transport;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0005783,cellular_component,endoplasmic reticulum;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005737,cellular_component,cytoplasm;GO:0050699,molecular_function,WW domain binding;GO:0010629,biological_process,negative regulation of gene expression;GO:0007165,biological_process,signal transduction;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0007034,biological_process,vacuolar transport;GO:0016021,cellular_component,integral component of membrane;GO:0031398,biological_process,positive regulation of protein ubiquitination","-"]
["PSMD14",10.30289537,4.852381494,1.085582128,5.886921628,{"v":2.62E-5,"d":"2.62E-05"},{"v":9.09E-5,"d":"9.09E-05"},"ENSG00000115233","I3MNR6,Proteasome 26S subunit, non-ATPase 14","XP_005315813.1,-","PF01398,JAB1/Mov34/MPN/PAD-1 ubiquitin protease","IPR037518,MPN domain;IPR035299,26S Proteasome non-ATPase regulatory subunit 14;IPR024969,Rpn11/EIF3F, C-terminal;IPR000555,JAB1/MPN/MOV34 metalloenzyme domain","KOG1555,26S proteasome regulatory complex, subunit RPN11;COG1310,Predicted metal-dependent protease of the PAD1/JAB1 superfamily","GO:0006303,biological_process,double-strand break repair via nonhomologous end joining;GO:0061578,molecular_function,Lys63-specific deubiquitinase activity;GO:0022624,cellular_component,proteasome accessory complex;GO:0008541,cellular_component,proteasome regulatory particle, lid subcomplex;GO:0010950,biological_process,positive regulation of endopeptidase activity;GO:0070536,biological_process,protein K63-linked deubiquitination;GO:0061136,biological_process,regulation of proteasomal protein catabolic process;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0061133,molecular_function,endopeptidase activator activity;GO:0070628,molecular_function,proteasome binding;GO:0000502,cellular_component,proteasome complex;GO:0000724,biological_process,double-strand break repair via homologous recombination","-"]
["LLGL2",5.104087078,2.402892883,1.085499606,4.930905164,0.000318439,0.000860994,"ENSG00000073350","J3QRV5,Lethal","XP_016880116.1,lethal(2) giant larvae protein homolog 2 isoform X4","PF08366,LLGL2;PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR001680,WD40 repeat;IPR013577,Lethal giant larvae homologue 2;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR000664,Lethal(2) giant larvae protein","KOG1983,Tomosyn and related SNARE-interacting proteins;ENOG410XS6Z,-","GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005829,cellular_component,cytosol","-"]
["NAA30",4.00266023,1.883861438,1.085446229,4.543980823,0.000803507,0.001980826,"ENSG00000139977","H2Q8D2,N","XP_001164011.1,N-alpha-acetyltransferase 30","PF00583,Acetyltransferase (GNAT) family","IPR016181,Acyl-CoA N-acyltransferase;IPR000182,GNAT domain","KOG3139,N-acetyltransferase;COG0456,Acetyltransferases","GO:0017196,biological_process,N-terminal peptidyl-methionine acetylation;GO:0005737,cellular_component,cytoplasm;GO:0031417,cellular_component,NatC complex;GO:0016740,molecular_function,transferase activity;GO:0005844,cellular_component,polysome;GO:0008080,molecular_function,N-acetyltransferase activity;GO:0006474,biological_process,N-terminal protein amino acid acetylation;GO:0004596,molecular_function,peptide alpha-N-acetyltransferase activity;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["GOLT1B",2.945533605,1.383640834,1.085061022,3.159519656,0.016189067,0.029240254,"ENSG00000111711","A0A286XBS0,Golgi transport 1B","XP_005003880.1,-","-","IPR007305,Vesicle transport protein, Got1/SFT2-like","-","GO:0016192,biological_process,vesicle-mediated transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["CSRNP2",2.133963065,1.002412069,1.085061022,3.159519656,0.016189067,0.029240254,"ENSG00000110925","B2R7Q9,cDNA, FLJ93562","-","PF16019,Cysteine/serine-rich nuclear protein N-terminus","IPR031972,Cysteine/serine-rich nuclear protein, N-terminal domain;IPR023260,Cysteine/serine-rich nuclear protein family","KOG3813,Uncharacterized conserved protein (tumor-suppressor AXUD1 in humans);ENOG410XREB,-","-","-"]
["WDFY2",0.689055185,0.323678158,1.085061022,3.159519656,0.016189067,0.029240254,"ENSG00000139668","H2NJY0,WD repeat and FYVE domain containing 2","XP_002824343.1,WD repeat and FYVE domain-containing protein 2 isoform X1","PF01363,YVE zinc finger;PF00400,WD domain, G-beta repeat","IPR017455,Zinc finger, FYVE-related;IPR019775,WD40 repeat, conserved site;IPR011011,Zinc finger, FYVE/PHD-type;IPR017986,WD40-repeat-containing domain;IPR000306,FYVE zinc finger;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001680,WD40 repeat","COG2319,FOG: WD40 repeat;KOG1409,Uncharacterized conserved protein, contains WD40 repeats and FYVE domains","GO:0045600,biological_process,positive regulation of fat cell differentiation;GO:0005737,cellular_component,cytoplasm;GO:0046872,molecular_function,metal ion binding;GO:0005769,cellular_component,early endosome;GO:0031982,cellular_component,vesicle;GO:0001934,biological_process,positive regulation of protein phosphorylation","-"]
["YPEL2",1.287715107,0.604893864,1.085061022,3.159519656,0.016189067,0.029240254,"ENSG00000175155","A0A091MQ78,Protein yippee-like","XP_009070573.1,-","PF03226,Yippee zinc-binding/DNA-binding /Mis18, centromere assembly","IPR034751,Yippee domain;IPR004910,Yippee/Mis18/Cereblon","-","GO:0046872,molecular_function,metal ion binding","-"]
["RP4-614O4.13",7.639032737,3.588374484,1.085061022,3.159519656,0.016189067,0.029240254,"ENSG00000279253","Q6ZP70,cDNA FLJ26432 fis, clone KDN01418","-","-","-","ENOG4110S4J,-;ENOG410KC5S,-","-","-"]
["CCDC157",1.694598668,0.796024161,1.085061022,3.159519656,0.016189067,0.029240254,"ENSG00000187860","H2P415,Coiled-coil domain containing 157","-","-","IPR029681,Coiled-coil domain-containing protein 157","ENOG410IKQF,-;ENOG410Z8T2,-","-","-"]
["AGFG2",2.037354295,0.957030873,1.085061022,3.159519656,0.016189067,0.029240254,"ENSG00000106351","A4D2D6,HIV-1 Rev binding protein-like","NP_006067.3,arf-GAP domain and FG repeat-containing protein 2","PF01412,Putative GTPase activating protein for Arf","IPR001164,Arf GTPase activating protein;IPR038508,ArfGAP domain superfamily;IPR037278,ARFGAP/RecO-like zinc finger","KOG0702,Predicted GTPase-activating protein;ENOG41122WA,-","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0046872,molecular_function,metal ion binding;GO:0005096,molecular_function,GTPase activator activity","-"]
["H1F0",45.38487418,21.38758835,1.084914261,6.305738553,{"v":1.06E-5,"d":"1.06E-05"},{"v":4e-05,"d":"4.00E-05"},"ENSG00000189060","G7PFD9,Uncharacterized protein","XP_005567396.1,-","PF00538,linker histone H1 and H5 family","IPR036390,Winged helix DNA-binding domain superfamily;IPR005819,Histone H5;IPR005818,Linker histone H1/H5, domain H15;IPR036388,Winged helix-like DNA-binding domain superfamily","-","GO:0000786,cellular_component,nucleosome;GO:0003680,molecular_function,AT DNA binding;GO:0005719,cellular_component,nuclear euchromatin;GO:0015629,cellular_component,actin cytoskeleton;GO:0031490,molecular_function,chromatin DNA binding;GO:0000790,cellular_component,nuclear chromatin;GO:0003690,molecular_function,double-stranded DNA binding;GO:0005634,cellular_component,nucleus;GO:0005694,cellular_component,chromosome;GO:0003677,molecular_function,DNA binding;GO:0005794,cellular_component,Golgi apparatus;GO:0016604,cellular_component,nuclear body;GO:0006334,biological_process,nucleosome assembly","-"]
["LAPTM4A",20.37813169,9.597541814,1.084880264,4.906051376,0.000258671,7.15012E-4,"ENSG00000068697","G1QPS8,Lysosomal protein transmembrane 4 alpha","XP_003276023.1,-","PF03821,olgi 4-transmembrane spanning transporter","IPR018396,Lysosomal-associated transmembrane protein, 4A/5;IPR004687,Lysosomal-associated transmembrane protein 4/5","ENOG4111K1Z,-;ENOG410IEGH,-","GO:0031902,cellular_component,late endosome membrane;GO:0005794,cellular_component,Golgi apparatus;GO:0005765,cellular_component,lysosomal membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","K12387,ko04142,Lysosome"]
["SNRNP70",38.12340505,17.97811814,1.084123451,7.047112595,{"v":2.6e-06,"d":"2.60E-06"},{"v":1.12e-05,"d":"1.12E-05"},"ENSG00000104852","G3QYW8,Small nuclear ribonucleoprotein U1 subunit 70","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF12220,U1 small nuclear ribonucleoprotein of 70kDa MW N terminal","IPR022023,U1 small nuclear ribonucleoprotein of 70kDa N-terminal;IPR035979,RNA-binding domain superfamily;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain","-","GO:0005685,cellular_component,U1 snRNP;GO:0048026,biological_process,positive regulation of mRNA splicing, via spliceosome;GO:0003723,molecular_function,RNA binding;GO:0005681,cellular_component,spliceosomal complex;GO:0003676,molecular_function,nucleic acid binding;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0005634,cellular_component,nucleus;GO:0043484,biological_process,regulation of RNA splicing;GO:0005654,cellular_component,nucleoplasm","K11093,ko03040,Spliceosome"]
["GLCE",3.044360837,1.433218689,1.084122274,3.965356668,3.649111E-3,0.007750449,"ENSG00000138604","H2Q9P8,Glucuronic acid epimerase","XP_016783922.1,-;XP_001174876.1,D-glucuronyl C5-epimerase","PF06662,-glucuronyl C5-epimerase C-terminus","IPR010598,D-glucuronyl C5-epimerase, C-terminal","ENOG410XQJ3,-;KOG3760,Heparan sulfate-glucuronic acid C5-epimerase","GO:0005794,cellular_component,Golgi apparatus;GO:0006024,biological_process,glycosaminoglycan biosynthetic process;GO:0050379,molecular_function,UDP-glucuronate 5'-epimerase activity;GO:0047464,molecular_function,heparosan-N-sulfate-glucuronate 5-epimerase activity;GO:0016857,molecular_function,racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0015012,biological_process,heparan sulfate proteoglycan biosynthetic process;GO:0016021,cellular_component,integral component of membrane;GO:0030210,biological_process,heparin biosynthetic process","K01793,ko00534,Glycosaminoglycan biosynthesis - heparan sulfate / heparin"]
["PEX5",5.32208416,2.507628406,1.083763045,4.477987949,1.057007E-3,2.542664E-3,"ENSG00000139197","G3QL79,Peroxisomal biogenesis factor 5","XP_018894767.1,-;XP_018894763.1,-;XP_018894762.1,-;XP_018894765.1,-;XP_018894764.1,-","PF13432,Tetratricopeptide repeat","IPR024111,Peroxisomal targeting signal 1 receptor family;IPR024113,Peroxisomal targeting signal 1 receptor;IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR011990,Tetratricopeptide-like helical domain superfamily","-","-","-"]
["C15orf52",6.292219562,2.966859423,1.083455937,5.153466023,1.44609E-4,0.000423589,"ENSG00000188549","K7B319,Chromosome 15 open reading frame 52","-","PF15266,omain of unknown function (DUF4594)","IPR029336,Protein of unknown function DUF4594","ENOG410YRQX,-;ENOG410IKY1,-","-","-"]
["SGCE",18.27333666,8.619336796,1.082897671,5.132200016,0.000170009,0.000488737,"ENSG00000127990","B7Z2R4,Epsilon-sarcoglycan","-","PF05510,Sarcoglycan alpha/epsilon","IPR030775,Epsilon-sarcoglycan;IPR006644,Dystroglycan-type cadherin-like;IPR008908,Sarcoglycan alpha/epsilon","-","GO:0016012,cellular_component,sarcoglycan complex;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TSKU",2.529229337,1.189772858,1.082688385,3.072071347,0.023393321,0.040324412,"ENSG00000182704","A0A024R5J8,Leucine rich repeat containing 54, isoform CRA_a","NP_056331.2,tsukushin isoform b precursor;NP_001305408.1,-;NP_001305407.1,-;NP_001245139.1,-","PF13855,Leucine rich repeat","IPR001611,Leucine-rich repeat;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0021540,biological_process,corpus callosum morphogenesis;GO:0043010,biological_process,camera-type eye development;GO:0030178,biological_process,negative regulation of Wnt signaling pathway;GO:0021960,biological_process,anterior commissure morphogenesis;GO:0010468,biological_process,regulation of gene expression;GO:0021670,biological_process,lateral ventricle development;GO:0005615,cellular_component,extracellular space;GO:0061073,biological_process,ciliary body morphogenesis","-"]
["FOXRED1",1.846958881,0.868826529,1.082688385,3.072071347,0.023393321,0.040324412,"ENSG00000110074","K7D333,FAD-dependent oxidoreductase domain containing 1","-","PF01266,AD dependent oxidoreductase","IPR006076,FAD dependent oxidoreductase;IPR036188,FAD/NAD(P)-binding domain superfamily","-","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity","-"]
["PMAIP1",4.674830601,2.199083524,1.082688385,3.072071347,0.023393321,0.040324412,"ENSG00000141682","A0A0S2Z4V2,Phorbol-12-myristate-13-acetate-induced protein 1 isoform 1","-","PF15150,Phorbol-12-myristate-13-acetate-induced","IPR024140,Phorbol-12-myristate-13-acetate-induced protein 1","-","GO:0001836,biological_process,release of cytochrome c from mitochondria;GO:0006919,biological_process,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006915,biological_process,apoptotic process;GO:0006974,biological_process,cellular response to DNA damage stimulus","-"]
["TTC26",2.090067292,0.983186973,1.082688385,3.072071347,0.023393321,0.040324412,"ENSG00000105948","H2QVG7,Tetratricopeptide repeat domain 26","-","PF12895,Anaphase-promoting complex, cyclosome, subunit 3","IPR030511,Tetratricopeptide repeat protein 26;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","ENOG410XRMP,-;KOG3785,Uncharacterized conserved protein","-","-"]
["CALM3",151.5937279,71.57306231,1.082621587,8.679638265,{"v":4.32E-7,"d":"4.32E-07"},{"v":2.2e-06,"d":"2.20E-06"},"ENSG00000160014","A0A146N5G3,Uncharacterized protein","-","-","-","-","-","-"]
["STAM2",5.254293008,2.479109577,1.082166514,4.802104134,0.000472556,0.001228173,"ENSG00000115145","H2R6H2,Signal transducing adaptor molecule","-","PF02809,Ubiquitin interaction motif;PF00018,SH3 domain;PF00790,VHS domain","IPR035675,STAM2, SH3 domain;IPR008942,ENTH/VHS;IPR002014,VHS domain;IPR003903,Ubiquitin interacting motif;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain","ENOG410XTSY,-;KOG2199,Signal transducing adaptor protein STAM/STAM2","GO:0006886,biological_process,intracellular protein transport;GO:0005622,cellular_component,intracellular","-"]
["TOMM20",27.82212318,13.13614037,1.082128017,6.1974048,{"v":1.38E-5,"d":"1.38E-05"},{"v":5.09e-05,"d":"5.09E-05"},"ENSG00000173726","A0A1U7QW09,mitochondrial import receptor subunit TOM20 homolog","XP_005074302.1,-","-","IPR002056,Protein import receptor MAS20;IPR022422,Protein import receptor MAS20, metazoan;IPR023392,Mitochondrial outer membrane translocase complex, Tom20 domain superfamily","-","GO:0006605,biological_process,protein targeting;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0005742,cellular_component,mitochondrial outer membrane translocase complex;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0006886,biological_process,intracellular protein transport","-"]
["SENP3-EIF4A1",79.62573783,37.61751401,1.081632456,7.694555008,{"v":1.13E-6,"d":"1.13E-06"},{"v":5.25e-06,"d":"5.25E-06"},"ENSG00000277957","A0A087X0R7,SENP3-EIF4A1 readthrough","-","PF02902,Ulp1 protease family, C-terminal catalytic domain","IPR003653,Ulp1 protease family, C-terminal catalytic domain;IPR037945,Sentrin-specific protease 3","COG5160,Protease, Ulp1 family;KOG0778,Protease, Ulp1 family","GO:0006508,biological_process,proteolysis;GO:0016926,biological_process,protein desumoylation;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0071339,cellular_component,MLL1 complex;GO:0004175,molecular_function,endopeptidase activity;GO:0005634,cellular_component,nucleus","-"]
["RP11-640I15.1",32.85350521,15.49371807,1.081406446,3.86541174,5.239484E-3,0.010705818,"-","-","-","-","-","-","-","-"]
["CLN8",1.98322777,0.935290519,1.081406446,3.86541174,5.239484E-3,0.010705818,"ENSG00000182372","A0A024QZ57,Ceroid-lipofuscinosis, neuronal 8","XP_005266080.1,-;XP_005266078.1,-;XP_005266079.1,-;XP_011533048.1,-;NP_061764.2,protein CLN8;XP_011533047.1,-","PF03798,TLC domain","IPR006634,TRAM/LAG1/CLN8 homology domain","ENOG410XPW0,-;KOG4561,Uncharacterized conserved protein, contains TBC domain","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["AKT1",7.828823998,3.698763132,1.081118557,6.026349875,{"v":2e-05,"d":"2.00E-05"},{"v":7.12e-05,"d":"7.12E-05"},"ENSG00000142208","G3RB32,AKT serine/threonine kinase 1","XP_018865051.1,-","PF00433,Protein kinase C terminal domain;PF00069,Protein kinase domain;PF00169,PH domain","IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR017892,Protein kinase, C-terminal;IPR011009,Protein kinase-like domain superfamily;IPR000961,AGC-kinase, C-terminal;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR034676,Protein kinase B alpha, catalytic domain;IPR000719,Protein kinase domain","-","GO:0016301,molecular_function,kinase activity;GO:1990418,biological_process,response to insulin-like growth factor stimulus;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0060416,biological_process,response to growth hormone;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","K04456,ko04728,Dopaminergic synapse;K04456,ko04933,AGE-RAGE signaling pathway in diabetic complications;K04456,ko05210,Colorectal cancer;K04456,ko05145,Toxoplasmosis;K04456,ko04014,Ras signaling pathway;K04456,ko04664,Fc epsilon RI signaling pathway;K04456,ko04212,Longevity regulating pathway - worm;K04456,ko05160,Hepatitis C;K04456,ko05222,Small cell lung cancer;K04456,ko04914,Progesterone-mediated oocyte maturation;K04456,ko04072,Phospholipase D signaling pathway;K04456,ko04012,ErbB signaling pathway;K04456,ko05161,Hepatitis B;K04456,ko04662,B cell receptor signaling pathway;K04456,ko01522,Endocrine resistance;K04456,ko04261,Adrenergic signaling in cardiomyocytes;K04456,ko04068,FoxO signaling pathway;K04456,ko04923,Regulation of lipolysis in adipocytes;K04456,ko04024,cAMP signaling pathway;K04456,ko05211,Renal cell carcinoma;K04456,ko04066,HIF-1 signaling pathway;K04456,ko04917,Prolactin signaling pathway;K04456,ko04915,Estrogen signaling pathway;K04456,ko05162,Measles;K04456,ko05166,HTLV-I infection;K04456,ko04015,Rap1 signaling pathway;K04456,ko04722,Neurotrophin signaling pathway;K04456,ko05214,Glioma;K04456,ko04150,mTOR signaling pathway;K04456,ko04910,Insulin signaling pathway;K04456,ko04660,T cell receptor signaling pathway;K04456,ko04919,Thyroid hormone signaling pathway;K04456,ko04062,Chemokine signaling pathway;K04456,ko04611,Platelet activation;K04456,ko01524,Platinum drug resistance;K04456,ko05221,Acute myeloid leukemia;K04456,ko04666,Fc gamma R-mediated phagocytosis;K04456,ko05215,Prostate cancer;K04456,ko05230,Central carbon metabolism in cancer;K04456,ko04010,MAPK signaling pathway;K04456,ko05152,Tuberculosis;K04456,ko05223,Non-small cell lung cancer;K04456,ko05200,Pathways in cancer;K04456,ko04550,Signaling pathways regulating pluripotency of stem cells;K04456,ko04620,Toll-like receptor signaling pathway;K04456,ko04022,cGMP-PKG signaling pathway;K04456,ko04932,Non-alcoholic fatty liver disease (NAFLD);K04456,ko05164,Influenza A;K04456,ko04210,Apoptosis;K04456,ko04152,AMPK signaling pathway;K04456,ko04630,Jak-STAT signaling pathway;K04456,ko05212,Pancreatic cancer;K04456,ko04380,Osteoclast differentiation;K04456,ko04211,Longevity regulating pathway;K04456,ko05205,Proteoglycans in cancer;K04456,ko04922,Glucagon signaling pathway;K04456,ko04668,TNF signaling pathway;K04456,ko05231,Choline metabolism in cancer;K04456,ko04920,Adipocytokine signaling pathway;K04456,ko04213,Longevity regulating pathway - multiple species;K04456,ko04973,Carbohydrate digestion and absorption;K04456,ko04530,Tight junction;K04456,ko04725,Cholinergic synapse;K04456,ko04071,Sphingolipid signaling pathway;K04456,ko05142,Chagas disease (American trypanosomiasis);K04456,ko04151,PI3K-Akt signaling pathway;K04456,ko04510,Focal adhesion;K04456,ko05169,Epstein-Barr virus infection;K04456,ko04370,VEGF signaling pathway;K04456,ko01521,EGFR tyrosine kinase inhibitor resistance;K04456,ko05218,Melanoma;K04456,ko05220,Chronic myeloid leukemia;K04456,ko04931,Insulin resistance;K04456,ko05213,Endometrial cancer"]
["PSPC1",25.0425065,11.83588114,1.080752727,6.486605239,{"v":7.69e-06,"d":"7.69E-06"},{"v":3e-05,"d":"3.00E-05"},"ENSG00000121390","H2Q790,Paraspeckle component 1","-","PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF08075,NOPS (NUC059) domain","IPR012975,NOPS;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034523,PSP1, RNA recognition motif 2;IPR000504,RNA recognition motif domain;IPR035979,RNA-binding domain superfamily;IPR034522,PSP1, RNA recognition motif 1","KOG0115,RNA-binding protein p54nrb (RRM superfamily);ENOG410XQA0,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0001650,cellular_component,fibrillar center;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0002218,biological_process,activation of innate immune response;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0042382,cellular_component,paraspeckles;GO:0042752,biological_process,regulation of circadian rhythm;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0001047,molecular_function,core promoter binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["EMC10",4.065190429,1.920617514,1.080485195,5.043846412,0.000253972,0.000703594,"ENSG00000161671","M0R2A0,ER membrane protein complex subunit 10","-","-","IPR029615,ER membrane protein complex subunit 10","ENOG4111PEN,-;KOG4827,Uncharacterized conserved protein","-","-"]
["CTD-2410N18.5",558.0067596,263.8945759,1.080115596,7.639175774,{"v":1.2e-06,"d":"1.20E-06"},{"v":5.57E-6,"d":"5.57E-06"},"ENSG00000272772","A0A1D5RB04,Protein phosphatase 2 catalytic subunit alpha","-","-","IPR001232,S-phase kinase-associated protein 1-like;IPR016073,SKP1 component, POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily","-","GO:0006511,biological_process,ubiquitin-dependent protein catabolic process","-"]
["RP11-96O20.4",9.184779204,4.327630407,1.079974545,2.978901224,0.034093522,0.056009295,"ENSG00000260170","H3BNX3,Uncharacterized protein","-","PF07992,Pyridine nucleotide-disulphide oxidoreductase","IPR023753,FAD/NAD(P)-binding domain;IPR015904,Sulphide quinone-reductase;IPR036188,FAD/NAD(P)-binding domain superfamily","COG0446,Uncharacterized NAD(FAD)-dependent dehydrogenases;KOG3851,Sulfide:quinone oxidoreductase/flavo-binding protein","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity","-"]
["UNKL",1.299154785,0.612128133,1.079974545,2.978901224,0.034093522,0.056009295,"ENSG00000059145","E9PDK2,Putative E3 ubiquitin-protein ligase UNKL","XP_005255562.1,putative E3 ubiquitin-protein ligase UNKL isoform X2","PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar);PF13920,Zinc finger, C3HC4 type (RING finger)","IPR001841,Zinc finger, RING-type;IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","-","GO:0005829,cellular_component,cytosol;GO:0046872,molecular_function,metal ion binding","-"]
["RNF43",1.297250627,0.611230944,1.079974545,2.978901224,0.034093522,0.056009295,"ENSG00000108375","H2RBW0,Uncharacterized protein","XP_016788141.1,E3 ubiquitin-protein ligase RNF43 isoform X2;XP_003315684.2,-","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG0800,FOG: Predicted E3 ubiquitin ligase;ENOG41121N2,-","GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0016567,biological_process,protein ubiquitination;GO:0030178,biological_process,negative regulation of Wnt signaling pathway;GO:0005109,molecular_function,frizzled binding;GO:0038018,biological_process,Wnt receptor catabolic process;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016020,cellular_component,membrane;GO:0072089,biological_process,stem cell proliferation;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["SCN9A",0.939392701,0.442617544,1.079974545,2.978901224,0.034093522,0.056009295,"ENSG00000169432","G1QTF1,Sodium channel protein","-","PF16905,Voltage-dependent L-type calcium channel, IQ-associated;PF00520,Ion transport protein;PF06512,Sodium ion transport-associated;PF11933,Cytoplasmic domain of voltage-gated Na+ ion channel","IPR031649,Voltage-dependent L-type calcium channel, IQ-associated domain;IPR024583,Voltage-gated Na+ ion channel, cytoplasmic domain;IPR027359,Voltage-dependent channel domain superfamily;IPR000048,IQ motif, EF-hand binding site;IPR005821,Ion transport domain;IPR010526,Sodium ion transport-associated;IPR028803,Voltage gated sodium channel, alpha-9 subunit;IPR001696,Voltage gated sodium channel, alpha subunit","KOG2301,Voltage-gated Ca2+ channels, alpha1 subunits;ENOG410XNP6,-","GO:0005216,molecular_function,ion channel activity;GO:0048266,biological_process,behavioral response to pain;GO:0019233,biological_process,sensory perception of pain;GO:0001518,cellular_component,voltage-gated sodium channel complex;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0005272,molecular_function,sodium channel activity;GO:0009636,biological_process,response to toxic substance;GO:0005887,cellular_component,integral component of plasma membrane;GO:0055085,biological_process,transmembrane transport;GO:0006811,biological_process,ion transport;GO:0035725,biological_process,sodium ion transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0006954,biological_process,inflammatory response;GO:0016020,cellular_component,membrane;GO:0009791,biological_process,post-embryonic development;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0005248,molecular_function,voltage-gated sodium channel activity;GO:0016021,cellular_component,integral component of membrane;GO:0006814,biological_process,sodium ion transport","-"]
["TYW5",0.927578693,0.437051089,1.079974545,2.978901224,0.034093522,0.056009295,"ENSG00000162971","H2QZW0,Chromosome 2 open reading frame 60","XP_001169758.1,-","PF13621,Cupin-like domain","IPR029612,tRNA wybutosine-synthesizing protein 5;IPR003347,JmjC domain","KOG2132,Uncharacterized conserved protein, contains JmjC domain;ENOG410XQDR,-","GO:0042803,molecular_function,protein homodimerization activity;GO:0000049,molecular_function,tRNA binding;GO:0031591,biological_process,wybutosine biosynthetic process;GO:0016706,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0005506,molecular_function,iron ion binding;GO:0055114,biological_process,oxidation-reduction process","-"]
["MOCS3",1.906750089,0.898411326,1.079974545,2.978901224,0.034093522,0.056009295,"ENSG00000124217","H2QKK8,Adenylyltransferase and sulfurtransferase MOCS3","XP_514724.2,adenylyltransferase and sulfurtransferase MOCS3","PF00581,Rhodanese-like domain;PF00899,ThiF family","IPR028885,Adenylyltransferase and sulfurtransferase MOCS3/Uba4;IPR035985,Ubiquitin-activating enzyme;IPR001763,Rhodanese-like domain;IPR036873,Rhodanese-like domain superfamily;IPR000594,THIF-type NAD/FAD binding fold","COG0607,Rhodanese-related sulfurtransferase;KOG2017,Molybdopterin synthase sulfurylase;COG0476,Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2","GO:0002098,biological_process,tRNA wobble uridine modification;GO:0034227,biological_process,tRNA thio-modification;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0016783,molecular_function,sulfurtransferase activity;GO:0005524,molecular_function,ATP binding;GO:0005737,cellular_component,cytoplasm;GO:0032447,biological_process,protein urmylation;GO:0003824,molecular_function,catalytic activity;GO:0005829,cellular_component,cytosol;GO:0008641,molecular_function,ubiquitin-like modifier activating enzyme activity;GO:0016740,molecular_function,transferase activity;GO:0008152,biological_process,metabolic process;GO:0008033,biological_process,tRNA processing;GO:0000166,molecular_function,nucleotide binding;GO:0061604,molecular_function,molybdopterin-synthase sulfurtransferase activity;GO:0061605,molecular_function,molybdopterin-synthase adenylyltransferase activity;GO:0004792,molecular_function,thiosulfate sulfurtransferase activity;GO:0002143,biological_process,tRNA wobble position uridine thiolation;GO:0042292,molecular_function,URM1 activating enzyme activity;GO:0046872,molecular_function,metal ion binding;GO:0006777,biological_process,Mo-molybdopterin cofactor biosynthetic process;GO:0018192,biological_process,enzyme active site formation via cysteine modification to L-cysteine persulfide","K11996,ko04122,Sulfur relay system"]
["ZNF853",2.524206885,1.189340998,1.079974545,2.978901224,0.034093522,0.056009295,"ENSG00000236609","A0A1D5QEM8,Zinc finger protein 853","-","-","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding","-"]
["C7orf31",2.537364075,1.195540326,1.079974545,2.978901224,0.034093522,0.056009295,"ENSG00000153790","A0A024RA13,Chromosome 7 open reading frame 31, isoform CRA_c","-","PF15093,omain of unknown function (DUF4555)","IPR027886,Protein of unknown function DUF4555","ENOG410YGE7,-;ENOG410IIJZ,-","-","-"]
["HSPB2-C11orf52",8.76917932,4.139577052,1.079890258,3.812694882,0.004091265,0.008587548,"ENSG00000254445","F6ZR37,Heat shock protein beta-2","XP_002754426.1,-","PF00011,Hsp20/alpha crystallin family","IPR001436,Alpha crystallin/Heat shock protein;IPR031107,Small heat shock protein HSP20;IPR008978,HSP20-like chaperone;IPR002068,Alpha crystallin/Hsp20 domain","KOG3591,Alpha crystallins;ENOG410YERS,-","GO:0007525,biological_process,somatic muscle development","K09543,ko05169,Epstein-Barr virus infection;K09543,ko05205,Proteoglycans in cancer"]
["C11orf52",10.02609502,4.732916429,1.079890258,3.812694882,0.004091265,0.008587548,"ENSG00000149300","G3R7K7,Chromosome 11 open reading frame 52","XP_004052167.1,uncharacterized protein C11orf52 homolog","PF15147,omain of unknown function (DUF4578)","IPR028106,Protein of unknown function DUF4578","-","-","-"]
["STAT5B",4.088425023,1.931318584,1.079859058,4.336140054,1.41697E-3,3.299565E-3,"ENSG00000173757","G3RVS4,Signal transducer and activator of transcription","XP_018882485.1,signal transducer and activator of transcription 5B isoform X1","PF02865,STAT protein, protein interaction domain;PF01017,STAT protein, all-alpha domain;PF00017,SH2 domain;PF02864,STAT protein, DNA binding domain","IPR036860,SH2 domain superfamily;IPR015988,STAT transcription factor, coiled coil;IPR035858,STAT5a/5b;IPR035886,STAT5b, SH2 domain;IPR036535,STAT transcription factor, N-terminal domain superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR013801,STAT transcription factor, DNA-binding;IPR000980,SH2 domain;IPR012345,STAT transcription factor, DNA-binding, N-terminal;IPR013800,STAT transcription factor, all-alpha domain;IPR013799,STAT transcription factor, protein interaction;IPR001217,Transcription factor STAT","-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0060397,biological_process,JAK-STAT cascade involved in growth hormone signaling pathway;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0004871,molecular_function,signal transducer activity;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction","-"]
["CAB39",25.07508251,11.85946051,1.079804506,6.641517805,{"v":5.6e-06,"d":"5.60E-06"},{"v":2.25e-05,"d":"2.25E-05"},"ENSG00000135932","G5ASV9,Calcium-binding protein 39","XP_004868095.1,-","PF08569,Mo25-like","IPR011989,Armadillo-like helical;IPR013878,Mo25-like;IPR016024,Armadillo-type fold","-","GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0023014,biological_process,signal transduction by protein phosphorylation;GO:0035556,biological_process,intracellular signal transduction;GO:0005622,cellular_component,intracellular;GO:0032147,biological_process,activation of protein kinase activity;GO:0030295,molecular_function,protein kinase activator activity;GO:0071902,biological_process,positive regulation of protein serine/threonine kinase activity;GO:0010800,biological_process,positive regulation of peptidyl-threonine phosphorylation;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0043539,molecular_function,protein serine/threonine kinase activator activity;GO:0019900,molecular_function,kinase binding","K08272,ko04152,AMPK signaling pathway;K08272,ko04150,mTOR signaling pathway"]
["CTSL",49.47922723,23.40453179,1.079562705,6.444140208,{"v":8.56e-06,"d":"8.56E-06"},{"v":3.3e-05,"d":"3.30E-05"},"ENSG00000135047","H2QXF0,Cathepsin L1","XP_003312197.1,-;XP_009455110.1,-;XP_003951515.1,-;XP_001137800.2,-","PF08246,Cathepsin propeptide inhibitor domain (I29);PF00112,Papain family cysteine protease","IPR025660,Cysteine peptidase, histidine active site;IPR000169,Cysteine peptidase, cysteine active site;IPR000668,Peptidase C1A, papain C-terminal;IPR025661,Cysteine peptidase, asparagine active site;IPR013201,Cathepsin propeptide inhibitor domain (I29);IPR013128,Peptidase C1A","COG4870,Cysteine protease;KOG1543,Cysteine proteinase Cathepsin L","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0097655,molecular_function,serpin family protein binding;GO:0002250,biological_process,adaptive immune response;GO:0005518,molecular_function,collagen binding;GO:0042393,molecular_function,histone binding;GO:0005764,cellular_component,lysosome;GO:0043394,molecular_function,proteoglycan binding;GO:0001968,molecular_function,fibronectin binding;GO:0097067,biological_process,cellular response to thyroid hormone stimulus;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0030574,biological_process,collagen catabolic process;GO:0051603,biological_process,proteolysis involved in cellular protein catabolic process;GO:0004197,molecular_function,cysteine-type endopeptidase activity;GO:0008233,molecular_function,peptidase activity;GO:0005615,cellular_component,extracellular space","K01365,ko04210,Apoptosis;K01365,ko04612,Antigen processing and presentation;K01365,ko04142,Lysosome;K01365,ko05205,Proteoglycans in cancer;K01365,ko05323,Rheumatoid arthritis;K01365,ko04145,Phagosome"]
["SARS",120.5871645,57.05922349,1.079424825,8.416133086,{"v":5.86e-07,"d":"5.86E-07"},{"v":2.92E-6,"d":"2.92E-06"},"ENSG00000031698","Q5T5C7,Serine--tRNA ligase, cytoplasmic","NP_001317598.1,serine--tRNA ligase, cytoplasmic isoform b","PF02403,Seryl-tRNA synthetase N-terminal domain;PF00587,tRNA synthetase class II core domain (G, H, P, S and T)","IPR006195,Aminoacyl-tRNA synthetase, class II;IPR002317,Serine-tRNA ligase, type1;IPR015866,Serine-tRNA synthetase, type1, N-terminal;IPR002314,Aminoacyl-tRNA synthetase, class II (G/ P/ S/T);IPR010978,Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm;IPR033729,Serine-tRNA ligase catalytic core domain","KOG2509,Seryl-tRNA synthetase;COG0172,Seryl-tRNA synthetase","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0006434,biological_process,seryl-tRNA aminoacylation;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0004828,molecular_function,serine-tRNA ligase activity;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["CSRP1",5.707512699,2.699301496,1.07933716,5.466047366,{"v":8.19e-05,"d":"8.19E-05"},0.000252391,"ENSG00000159176","H2N475,Cysteine and glycine-rich protein 1","-","PF00412,LIM domain","IPR001781,Zinc finger, LIM-type","ENOG410ITI1,-;ENOG4111F3Y,-","GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding","-"]
["RP11-29G8.3",23.70054586,11.21490489,1.078944889,6.205259524,{"v":1.37e-05,"d":"1.37E-05"},{"v":5.05e-05,"d":"5.05E-05"},"ENSG00000261553","A0A0D9RYD3,LIM domain 7","-","PF00412,LIM domain;PF00595,PDZ domain (Also known as DHR or GLGF);PF00307,Calponin homology (CH) domain;PF15949,omain of unknown function (DUF4757)","IPR001715,Calponin homology domain;IPR029978,LIM domain only protein 7;IPR036872,CH domain superfamily;IPR001478,PDZ domain;IPR003096,Smooth muscle protein/calponin;IPR031865,Domain of unknown function DUF4757;IPR001781,Zinc finger, LIM-type;IPR036034,PDZ superfamily","-","GO:0023051,biological_process,regulation of signaling;GO:0030155,biological_process,regulation of cell adhesion;GO:0046872,molecular_function,metal ion binding","-"]
["PRKAG1",10.9452657,5.178175603,1.078683299,5.230900966,0.000141157,0.000414911,"ENSG00000181929","A0A096MQF5,Protein kinase AMP-activated non-catalytic subunit gamma 1","-","PF00571,CBS domain","IPR000644,CBS domain","-","GO:0019901,molecular_function,protein kinase binding;GO:0010628,biological_process,positive regulation of gene expression;GO:0004672,molecular_function,protein kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0051170,biological_process,import into nucleus","-"]
["PTPN2",16.50315415,7.811655604,1.078558028,6.409243987,{"v":8.86e-06,"d":"8.86E-06"},{"v":3.41e-05,"d":"3.41E-05"},"ENSG00000175354","G3R421,Tyrosine-protein phosphatase non-receptor type","-","PF00102,Protein-tyrosine phosphatase","IPR016130,Protein-tyrosine phosphatase, active site;IPR000242,PTP type protein phosphatase;IPR029021,Protein-tyrosine phosphatase-like;IPR012265,Protein-tyrosine phosphatase, non-receptor type-1/2;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR000387,Tyrosine specific protein phosphatases domain","-","GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0006470,biological_process,protein dephosphorylation;GO:0016020,cellular_component,membrane;GO:0016311,biological_process,dephosphorylation;GO:0016021,cellular_component,integral component of membrane;GO:0016791,molecular_function,phosphatase activity","-"]
["PITPNM1",6.443716146,3.048504684,1.078462008,4.973827568,0.000294684,0.000804037,"ENSG00000110697","A0A024R5I7,Phosphatidylinositol transfer protein, membrane-associated 1, isoform CRA_a","XP_016874075.1,-;NP_004901.2,membrane-associated phosphatidylinositol transfer protein 1 isoform a","PF02862,HD domain;PF02121,Phosphatidylinositol transfer protein","IPR031315,LNS2/PITP;IPR001666,Phosphatidylinositol transfer protein;IPR004177,DDHD domain;IPR036412,HAD-like superfamily;IPR023393,START-like domain superfamily","COG5083,Uncharacterized protein involved in plasmid maintenance;KOG3668,Phosphatidylinositol transfer protein","GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0046872,molecular_function,metal ion binding;GO:0005815,cellular_component,microtubule organizing center;GO:0005622,cellular_component,intracellular;GO:0015914,biological_process,phospholipid transport;GO:0005829,cellular_component,cytosol;GO:0044297,cellular_component,cell body;GO:0005548,molecular_function,phospholipid transporter activity","-"]
["PEF1",7.783830537,3.678305401,1.078251492,3.757961519,0.005498076,0.011166146,"ENSG00000162517","H2PYJ2,Penta-EF-hand domain containing 1","XP_513269.2,-","PF13405,-hand domain;PF13499,-hand domain pair","IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR011992,EF-hand domain pair","ENOG410YKQK,-;KOG0037,Ca2+-binding protein, EF-Hand protein superfamily","GO:0000139,cellular_component,Golgi membrane;GO:0046983,molecular_function,protein dimerization activity;GO:0005509,molecular_function,calcium ion binding;GO:1902527,biological_process,positive regulation of protein monoubiquitination;GO:0006508,biological_process,proteolysis;GO:0005737,cellular_component,cytoplasm;GO:0014029,biological_process,neural crest formation;GO:0046982,molecular_function,protein heterodimerization activity;GO:0051592,biological_process,response to calcium ion;GO:0014032,biological_process,neural crest cell development;GO:0031463,cellular_component,Cul3-RING ubiquitin ligase complex;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0048208,biological_process,COPII vesicle coating;GO:0030127,cellular_component,COPII vesicle coat;GO:0048306,molecular_function,calcium-dependent protein binding;GO:0004198,molecular_function,calcium-dependent cysteine-type endopeptidase activity;GO:0060090,molecular_function,molecular adaptor activity","-"]
["PWWP2B",12.54033208,5.932797195,1.078130249,4.66061743,0.000729458,1.815802E-3,"ENSG00000171813","K7BTA2,PWWP domain containing 2B","-","PF00855,PWWP domain","IPR000313,PWWP domain","ENOG410XSSY,-;ENOG410IIF8,-","-","-"]
["ACADVL",13.37391157,6.331010039,1.078065556,5.607829493,{"v":5.29e-05,"d":"5.29E-05"},1.70774E-4,"ENSG00000072778","Q53HR2,Acyl-Coenzyme A dehydrogenase, very long chain variant","-","PF00441,Acyl-CoA dehydrogenase, C-terminal domain;PF02771,Acyl-CoA dehydrogenase, N-terminal domain;PF02770,Acyl-CoA dehydrogenase, middle domain","IPR036250,Acyl-CoA dehydrogenase-like, C-terminal;IPR013786,Acyl-CoA dehydrogenase/oxidase, N-terminal;IPR009100,Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily;IPR037069,Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily;IPR009075,Acyl-CoA dehydrogenase/oxidase C-terminal;IPR006091,Acyl-CoA oxidase/dehydrogenase, central domain;IPR006089,Acyl-CoA dehydrogenase, conserved site","COG1960,Acyl-CoA dehydrogenases;KOG0137,Very-long-chain acyl-CoA dehydrogenase","GO:0016627,molecular_function,oxidoreductase activity, acting on the CH-CH group of donors;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0016491,molecular_function,oxidoreductase activity;GO:0003995,molecular_function,acyl-CoA dehydrogenase activity;GO:0008152,biological_process,metabolic process;GO:0055114,biological_process,oxidation-reduction process","-"]
["SNX12",15.73916955,7.449766189,1.077741286,4.949709489,3.06247E-4,0.000831391,"ENSG00000147164","A0A087X0R6,Sorting nexin-12","-","PF00787,PX domain","IPR036871,PX domain superfamily;IPR001683,Phox homologous domain","COG5391,Phox homology (PX) domain protein;KOG2527,Sorting nexin SNX11","GO:0035091,molecular_function,phosphatidylinositol binding","-"]
["MXD1",5.122349221,2.424843634,1.07721861,4.630568231,0.000767184,1.900014E-3,"ENSG00000059728","H2QI19,MAX dimerization protein 1","XP_525776.2,-","PF00010,Helix-loop-helix DNA-binding domain","IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","ENOG410XSF5,-;ENOG410IPD8,-","GO:0046983,molecular_function,protein dimerization activity;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005739,cellular_component,mitochondrion;GO:0000790,cellular_component,nuclear chromatin;GO:0005829,cellular_component,cytosol;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005654,cellular_component,nucleoplasm","-"]
["ARHGAP1",6.538084808,3.096200687,1.076995378,4.925180059,0.000366551,0.000978422,"ENSG00000175220","H2Q3I0,Rho GTPase activating protein 1","XP_508398.3,rho GTPase-activating protein 1 isoform X1","PF13716,ivergent CRAL/TRIO domain;PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain;IPR001251,CRAL-TRIO lipid binding domain;IPR036865,CRAL-TRIO lipid binding domain superfamily","KOG4406,CDC42 Rho GTPase-activating protein;ENOG410XR4J,-","GO:0097443,cellular_component,sorting endosome;GO:0017137,molecular_function,Rab GTPase binding;GO:0005737,cellular_component,cytoplasm;GO:0098706,biological_process,ferric iron import across plasma membrane;GO:2001136,biological_process,negative regulation of endocytic recycling;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0043087,biological_process,regulation of GTPase activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0033572,biological_process,transferrin transport;GO:0016197,biological_process,endosomal transport;GO:0005096,molecular_function,GTPase activator activity;GO:0010008,cellular_component,endosome membrane;GO:0007165,biological_process,signal transduction;GO:0045296,molecular_function,cadherin binding","-"]
["CST3",10.86082938,5.143296296,1.076995378,4.925180059,0.000366551,0.000978422,"ENSG00000101439","K7AAK0,Cystatin","XP_016793041.1,-","PF00031,Cystatin domain","IPR027214,Cystatin;IPR000010,Cystatin domain;IPR018073,Proteinase inhibitor I25, cystatin, conserved site","-","GO:0004866,molecular_function,endopeptidase inhibitor activity;GO:0060311,biological_process,negative regulation of elastin catabolic process;GO:0030414,molecular_function,peptidase inhibitor activity;GO:0006952,biological_process,defense response;GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0097435,biological_process,supramolecular fiber organization;GO:0002020,molecular_function,protease binding;GO:0010466,biological_process,negative regulation of peptidase activity;GO:0034103,biological_process,regulation of tissue remodeling;GO:0045861,biological_process,negative regulation of proteolysis;GO:0010711,biological_process,negative regulation of collagen catabolic process;GO:0004869,molecular_function,cysteine-type endopeptidase inhibitor activity;GO:0010716,biological_process,negative regulation of extracellular matrix disassembly;GO:0001540,molecular_function,amyloid-beta binding;GO:0042802,molecular_function,identical protein binding;GO:0060313,biological_process,negative regulation of blood vessel remodeling;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space","K13899,ko04970,Salivary secretion"]
["SEC62",32.43811016,15.3747227,1.076915122,7.572827585,{"v":1.53E-6,"d":"1.53E-06"},{"v":6.96e-06,"d":"6.96E-06"},"ENSG00000008952","H2R3Q3,SEC62 homolog","XP_001162878.1,-","PF03839,Translocation protein Sec62","IPR004728,Translocation protein Sec62","KOG2927,Membrane component of ER protein translocation complex;COG5232,Preprotein translocase subunit Sec62","GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0015031,biological_process,protein transport;GO:0016021,cellular_component,integral component of membrane;GO:0006620,biological_process,posttranslational protein targeting to endoplasmic reticulum membrane;GO:0016020,cellular_component,membrane","K12275,ko04141,Protein processing in endoplasmic reticulum;K12275,ko03060,Protein export"]
["RASA3",1.894496225,0.894315512,1.076840191,2.879203427,0.038802283,0.06293541,"ENSG00000185989","H2Q7U7,RAS p21 protein activator 3","-","PF00779,BTK motif;PF00616,TPase-activator protein for Ras-like GTPase;PF00168,C2 domain;PF00169,PH domain","IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR001936,Ras GTPase-activating domain;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR008936,Rho GTPase activation protein;IPR023152,Ras GTPase-activating protein, conserved site;IPR001562,Zinc finger, Btk motif","ENOG410Y128,-;KOG2059,Ras GTPase-activating protein","GO:0005096,molecular_function,GTPase activator activity;GO:0046580,biological_process,negative regulation of Ras protein signal transduction;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0031235,cellular_component,intrinsic component of the cytoplasmic side of the plasma membrane;GO:0043087,biological_process,regulation of GTPase activity;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0015278,molecular_function,calcium-release channel activity;GO:0051209,biological_process,release of sequestered calcium ion into cytosol;GO:0007165,biological_process,signal transduction","-"]
["PFKFB2",1.630107892,0.771199635,1.076474655,3.701050444,0.007431705,0.014640522,"ENSG00000123836","G3R958,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2","-","PF01591,6-phosphofructo-2-kinase;PF00300,Histidine phosphatase superfamily (branch 1)","IPR013079,6-phosphofructo-2-kinase;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR013078,Histidine phosphatase superfamily, clade-1;IPR001345,Phosphoglycerate/bisphosphoglycerate mutase, active site;IPR003094,Fructose-2,6-bisphosphatase;IPR029033,Histidine phosphatase superfamily","-","GO:0003824,molecular_function,catalytic activity;GO:0005524,molecular_function,ATP binding;GO:0006003,biological_process,fructose 2,6-bisphosphate metabolic process;GO:0008152,biological_process,metabolic process;GO:0046835,biological_process,carbohydrate phosphorylation;GO:0006000,biological_process,fructose metabolic process;GO:0003873,molecular_function,6-phosphofructo-2-kinase activity","K19029,ko04152,AMPK signaling pathway;K19029,ko04919,Thyroid hormone signaling pathway;K19029,ko00051,Fructose and mannose metabolism"]
["ARHGAP8",3.331104242,1.575936409,1.076474655,3.701050444,0.007431705,0.014640522,"ENSG00000241484","A2RU51,PRR5-ARHGAP8 fusion","-","PF13716,ivergent CRAL/TRIO domain;PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain;IPR001251,CRAL-TRIO lipid binding domain;IPR036865,CRAL-TRIO lipid binding domain superfamily","KOG4406,CDC42 Rho GTPase-activating protein;ENOG410XR4J,-","GO:0007165,biological_process,signal transduction","-"]
["CTA-941F9.10",0.719202586,0.340252799,1.076474655,3.701050444,0.007431705,0.014640522,"ENSG00000280383","H2PFS8,Uncharacterized protein","-","-","-","-","-","-"]
["UBXN2A",5.726087176,2.713076172,1.07622294,4.900224966,0.000298751,0.000813366,"ENSG00000173960","G3QJ24,UBX domain protein 2A","XP_004028964.2,UBX domain-containing protein 2A isoform X2","PF00789,UBX domain;PF08059,SEP domain","IPR029071,Ubiquitin-like domain superfamily;IPR012989,SEP domain;IPR001012,UBX domain;IPR036241,NSFL1 cofactor p47, SEP domain superfamily","-","-","-"]
["DNAJB1",108.3832254,51.39818746,1.076213778,8.200770087,{"v":7.64e-07,"d":"7.64E-07"},{"v":3.7e-06,"d":"3.70E-06"},"ENSG00000132002","H2NXT6,DnaJ heat shock protein family","XP_002828840.1,-","PF01556,naJ C terminal domain;PF00226,naJ domain","IPR002939,Chaperone DnaJ, C-terminal;IPR036869,Chaperone J-domain superfamily;IPR018253,DnaJ domain, conserved site;IPR008971,HSP40/DnaJ peptide-binding;IPR001623,DnaJ domain","COG0484,DnaJ-class molecular chaperone with C-terminal Zn finger domain;KOG0714,Molecular chaperone (DnaJ superfamily)","GO:0006457,biological_process,protein folding;GO:0051087,molecular_function,chaperone binding;GO:0005737,cellular_component,cytoplasm;GO:0001671,molecular_function,ATPase activator activity;GO:0090084,biological_process,negative regulation of inclusion body assembly;GO:0030544,molecular_function,Hsp70 protein binding;GO:0005634,cellular_component,nucleus;GO:0051085,biological_process,chaperone cofactor-dependent protein refolding;GO:0032781,biological_process,positive regulation of ATPase activity;GO:0051082,molecular_function,unfolded protein binding;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol;GO:0097201,biological_process,negative regulation of transcription from RNA polymerase II promoter in response to stress;GO:0001106,molecular_function,RNA polymerase II transcription corepressor activity;GO:0051117,molecular_function,ATPase binding","K09507,ko04141,Protein processing in endoplasmic reticulum;K09507,ko05164,Influenza A"]
["GTF2A1",8.009361111,3.796071588,1.076171799,5.360314993,0.000123076,0.000364964,"ENSG00000165417","A0A0D9RGW3,General transcription factor IIA subunit 1","XP_007985678.1,-","PF03153,Transcription factor IIA, alpha/beta subunit","IPR009088,Transcription factor IIA, beta-barrel;IPR004855,Transcription factor IIA, alpha/beta subunit","-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0001103,molecular_function,RNA polymerase II repressing transcription factor binding;GO:0005672,cellular_component,transcription factor TFIIA complex;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0008134,molecular_function,transcription factor binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005829,cellular_component,cytosol;GO:0006367,biological_process,transcription initiation from RNA polymerase II promoter;GO:0017025,molecular_function,TBP-class protein binding;GO:0005634,cellular_component,nucleus;GO:0005669,cellular_component,transcription factor TFIID complex;GO:0005654,cellular_component,nucleoplasm","K03122,ko03022,Basal transcription factors;K03122,ko05203,Viral carcinogenesis"]
["TRIM41",4.859373433,2.303343752,1.076155593,5.544881644,{"v":7.13e-05,"d":"7.13E-05"},0.000223281,"ENSG00000146063","F7DUG0,E3 ubiquitin-protein ligase TRIM41 isoform 1","-","PF00643,B-box zinc finger","IPR017907,Zinc finger, RING-type, conserved site;IPR003879,Butyrophylin-like, SPRY domain;IPR001870,B30.2/SPRY domain;IPR003877,SPRY domain;IPR001841,Zinc finger, RING-type;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR000315,B-box-type zinc finger;IPR006574,SPRY-associated","ENOG4111G04,-;KOG2177,Predicted E3 ubiquitin ligase","GO:0008270,molecular_function,zinc ion binding;GO:0016874,molecular_function,ligase activity;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["GOLGA2",37.21721283,17.65174428,1.075946849,7.583706834,{"v":1.47e-06,"d":"1.47E-06"},{"v":6.75e-06,"d":"6.75E-06"},"ENSG00000167110","K7C8U6,Golgin A2","XP_001156160.2,golgin subfamily A member 2 isoform X2;XP_016817248.1,-","PF15070,Putative golgin subfamily A member 2-like protein 5","IPR024858,Golgin subfamily A","ENOG410ZIE4,-;KOG4725,Uncharacterized conserved protein","GO:0005794,cellular_component,Golgi apparatus;GO:0005801,cellular_component,cis-Golgi network","-"]
["SPECC1L-ADORA2A",14.23842264,6.760303187,1.074008006,6.043974629,{"v":1.95E-5,"d":"1.95E-05"},{"v":6.96e-05,"d":"6.96E-05"},"ENSG00000258555","F8WAN1,SPECC1L-ADORA2A readthrough","-","-","-","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);KOG4678,FOG: Calponin homology domain","-","-"]
["SNTB2",2.308473311,1.094976576,1.073630561,4.136503769,0.00251957,0.005555966,"ENSG00000168807","G1R088,Syntrophin beta 2","-","PF00595,PDZ domain (Also known as DHR or GLGF)","IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR028550,Beta-2-syntrophin;IPR015482,Syntrophin","ENOG4111J6R,-;ENOG410IMRK,-","GO:0005737,cellular_component,cytoplasm;GO:0045202,cellular_component,synapse;GO:0005198,molecular_function,structural molecule activity","-"]
["VRK2",16.51190523,7.843753031,1.072944317,5.444979625,{"v":8.59e-05,"d":"8.59E-05"},0.000263006,"ENSG00000028116","H2QHX9,Vaccinia related kinase 2","XP_009440771.1,-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","KOG1164,Casein kinase (serine/threonine/tyrosine protein kinase);ENOG410XPGP,-","GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0008360,biological_process,regulation of cell shape;GO:0005737,cellular_component,cytoplasm;GO:0005524,molecular_function,ATP binding;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0004672,molecular_function,protein kinase activity","-"]
["DUS3L",4.172830669,1.979295934,1.072430542,3.579945871,0.011137544,0.020948632,"ENSG00000141994","B2RDV7,tRNA-dihydrouridine","NP_064560.2,tRNA-dihydrouridine(47) synthase","PF01207,ihydrouridine synthase (Dus)","IPR035587,DUS-like, FMN-binding domain;IPR001269,tRNA-dihydrouridine synthase;IPR000571,Zinc finger, CCCH-type;IPR018517,tRNA-dihydrouridine synthase, conserved site;IPR013785,Aldolase-type TIM barrel","KOG2333,Uncharacterized conserved protein;COG0042,tRNA-dihydrouridine synthase","GO:0002943,biological_process,tRNA dihydrouridine synthesis;GO:0003824,molecular_function,catalytic activity;GO:0017150,molecular_function,tRNA dihydrouridine synthase activity;GO:0046872,molecular_function,metal ion binding;GO:0016491,molecular_function,oxidoreductase activity;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0055114,biological_process,oxidation-reduction process;GO:0008033,biological_process,tRNA processing","-"]
["PHGDH",43.6315066,20.74852125,1.072138554,7.506464397,{"v":1.78e-06,"d":"1.78E-06"},{"v":7.99e-06,"d":"7.99E-06"},"ENSG00000092621","K7DD09,D-3-phosphoglycerate dehydrogenase","-","PF00389,-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain;PF02826,-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain","IPR029009,Allosteric substrate binding domain superfamily;IPR036291,NAD(P)-binding domain superfamily;IPR029752,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1;IPR006140,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain;IPR029753,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site;IPR006236,D-3-phosphoglycerate dehydrogenase;IPR006139,D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain","KOG0068,D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily;COG0111,Phosphoglycerate dehydrogenase and related dehydrogenases","GO:0006544,biological_process,glycine metabolic process;GO:0006566,biological_process,threonine metabolic process;GO:0009448,biological_process,gamma-aminobutyric acid metabolic process;GO:0021782,biological_process,glial cell development;GO:0022008,biological_process,neurogenesis;GO:0004617,molecular_function,phosphoglycerate dehydrogenase activity;GO:0051287,molecular_function,NAD binding;GO:0021915,biological_process,neural tube development;GO:0019530,biological_process,taurine metabolic process;GO:0021510,biological_process,spinal cord development;GO:0006541,biological_process,glutamine metabolic process;GO:0008652,biological_process,cellular amino acid biosynthetic process;GO:0016491,molecular_function,oxidoreductase activity;GO:0070314,biological_process,G1 to G0 transition;GO:0008152,biological_process,metabolic process;GO:0010468,biological_process,regulation of gene expression;GO:0006564,biological_process,L-serine biosynthetic process;GO:0043209,cellular_component,myelin sheath;GO:0006563,biological_process,L-serine metabolic process;GO:0016616,molecular_function,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0055114,biological_process,oxidation-reduction process;GO:0031175,biological_process,neuron projection development","-"]
["NOL9",3.972321092,1.886996393,1.071999796,4.470101216,1.248339E-3,0.00295695,"ENSG00000162408","H2PXX0,Nucleolar protein 9","XP_514340.2,polynucleotide 5'-hydroxyl-kinase NOL9 isoform X1","PF16575,mRNA cleavage and polyadenylation factor CLP1 P-loop","IPR032319,Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain","KOG2750,Uncharacterized conserved protein similar to ATP/GTP-binding protein;COG1341,Predicted GTPase or GTP-binding protein","GO:0051731,molecular_function,polynucleotide 5'-hydroxyl-kinase activity;GO:0000460,biological_process,maturation of 5.8S rRNA;GO:0005730,cellular_component,nucleolus;GO:0016740,molecular_function,transferase activity;GO:0000448,biological_process,cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0005634,cellular_component,nucleus;GO:0045111,cellular_component,intermediate filament cytoskeleton;GO:0016310,biological_process,phosphorylation","-"]
["ENO3",24.56484262,11.68045366,1.071979409,6.296989151,{"v":1.32e-05,"d":"1.32E-05"},{"v":4.89e-05,"d":"4.89E-05"},"ENSG00000108515","H2QBZ4,Enolase 3","XP_009429956.1,-;XP_511294.2,-;XP_003339342.1,-","PF00113,nolase, C-terminal TIM barrel domain;PF03952,nolase, N-terminal domain","IPR020811,Enolase, N-terminal;IPR029017,Enolase-like, N-terminal;IPR020809,Enolase, conserved site;IPR000941,Enolase;IPR034390,Enolase-like superfamily;IPR020810,Enolase, C-terminal TIM barrel domain;IPR036849,Enolase-like, C-terminal domain superfamily","KOG2670,Enolase;COG0148,Enolase","GO:0006096,biological_process,glycolytic process;GO:0046872,molecular_function,metal ion binding;GO:0004634,molecular_function,phosphopyruvate hydratase activity;GO:0005886,cellular_component,plasma membrane;GO:0000287,molecular_function,magnesium ion binding;GO:0016020,cellular_component,membrane;GO:0000015,cellular_component,phosphopyruvate hydratase complex;GO:0005829,cellular_component,cytosol","K01689,ko00680,Methane metabolism;K01689,ko00010,Glycolysis / Gluconeogenesis;K01689,ko03018,RNA degradation;K01689,ko04066,HIF-1 signaling pathway;K01689,ko01200,Carbon metabolism;K01689,ko01230,Biosynthesis of amino acids"]
["RNF115",4.494988712,2.136741966,1.071801675,5.226266319,0.000159897,0.00046281,"ENSG00000265491","H2N631,Ring finger protein 115","XP_002810371.1,E3 ubiquitin-protein ligase RNF115 isoform X1","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG0800,FOG: Predicted E3 ubiquitin ligase;ENOG41121N2,-","GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0070936,biological_process,protein K48-linked ubiquitination;GO:0042059,biological_process,negative regulation of epidermal growth factor receptor signaling pathway;GO:0043162,biological_process,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0070534,biological_process,protein K63-linked ubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0051865,biological_process,protein autoubiquitination;GO:0005829,cellular_component,cytosol","-"]
["SUPT6H",18.15608644,8.638960887,1.071239925,7.161269379,{"v":2.72e-06,"d":"2.72E-06"},{"v":1.17E-5,"d":"1.17E-05"},"ENSG00000109111","G7NGK3,Transcription elongation factor spt6","XP_014974390.1,-","PF14639,Holliday-junction resolvase-like of SPT6;PF14635,Helix-hairpin-helix motif;PF14641,Helix-turn-helix DNA-binding domain of SPT6;PF14633,SH2 domain;PF14878,eath-like domain of SPT6;PF00575,S1 RNA binding domain;PF14632,Acidic N-terminal SPT6","IPR017072,Transcription elongation factor Spt6;IPR028088,Helix-turn-helix DNA-binding domain of Spt6;IPR032706,Transcription elongation factor Spt6, helix-hairpin-helix motif;IPR036860,SH2 domain superfamily;IPR027999,Death-like domain of Spt6;IPR000980,SH2 domain;IPR010994,RuvA domain 2-like;IPR035420,Spt6, SH2 domain;IPR035019,Spt6, SH2 domain, N terminus;IPR028083,Spt6 acidic, N-terminal domain;IPR035018,Spt6, SH2 domain, C terminus;IPR003029,S1 domain;IPR006641,YqgF/RNase H-like domain;IPR012337,Ribonuclease H-like superfamily;IPR028231,Transcription elongation factor Spt6, YqgF domain;IPR022967,RNA-binding domain, S1;IPR012340,Nucleic acid-binding, OB-fold","COG2183,Transcriptional accessory protein;KOG1856,Transcription elongation factor SPT6","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003677,molecular_function,DNA binding;GO:0045191,biological_process,regulation of isotype switching;GO:0061086,biological_process,negative regulation of histone H3-K27 methylation;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0032784,biological_process,regulation of DNA-templated transcription, elongation;GO:0003746,molecular_function,translation elongation factor activity;GO:0051147,biological_process,regulation of muscle cell differentiation;GO:0042393,molecular_function,histone binding;GO:0032968,biological_process,positive regulation of transcription elongation from RNA polymerase II promoter;GO:0010793,biological_process,regulation of mRNA export from nucleus;GO:0006414,biological_process,translational elongation;GO:0050684,biological_process,regulation of mRNA processing;GO:0006351,biological_process,transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0000991,molecular_function,transcription factor activity, core RNA polymerase II binding;GO:0005634,cellular_component,nucleus;GO:0006139,biological_process,nucleobase-containing compound metabolic process","-"]
["COQ5",16.65891626,7.922104697,1.071037548,4.992085439,0.00028371,0.000777546,"ENSG00000110871","H2Q714,2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial","XP_509428.2,2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial","PF13649,Methyltransferase domain;PF13489,Methyltransferase domain;PF08242,Methyltransferase domain;PF13847,Methyltransferase domain;PF08241,Methyltransferase domain;PF01209,ubiE/COQ5 methyltransferase family","IPR023576,UbiE/COQ5 methyltransferase, conserved site;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR004033,UbiE/COQ5 methyltransferase","KOG1540,Ubiquinone biosynthesis methyltransferase COQ5;COG2226,Methylase involved in ubiquinone/menaquinone biosynthesis","GO:0005739,cellular_component,mitochondrion;GO:0102005,molecular_function,2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity;GO:0032991,cellular_component,protein-containing complex;GO:0006744,biological_process,ubiquinone biosynthetic process;GO:0016740,molecular_function,transferase activity;GO:0005759,cellular_component,mitochondrial matrix;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0031314,cellular_component,extrinsic component of mitochondrial inner membrane;GO:0016020,cellular_component,membrane;GO:0032259,biological_process,methylation;GO:0043430,molecular_function,2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity;GO:0008168,molecular_function,methyltransferase activity","K06127,ko00130,Ubiquinone and other terpenoid-quinone biosynthesis"]
["LARP1B",2.430779467,1.155319244,1.070568644,4.048155667,0.002579339,0.00567377,"ENSG00000138709","K7CU93,La ribonucleoprotein domain family, member 1B","XP_517433.3,la-related protein 1B isoform X8","PF05383,La domain","IPR006630,La-type HTH domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR006607,Protein of unknown function DM15","KOG2590,RNA-binding protein LARP/SRO9 and related La domain proteins;COG5193,La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation","GO:0003723,molecular_function,RNA binding;GO:0030529,,","-"]
["STPG1",1.70192326,0.808475191,1.070115962,3.515314118,0.008680466,0.016808416,"ENSG00000001460","A0A024RAC8,Chromosome 1 open reading frame 201, isoform CRA_b","-","PF07004,Sperm-tail PG-rich repeat","IPR010736,Sperm-tail PG-rich repeat","ENOG410IK80,-;ENOG4111MU0,-","-","-"]
["C1orf109",3.266817515,1.551856641,1.070115962,3.515314118,0.008680466,0.016808416,"ENSG00000116922","B4DRQ5,cDNA FLJ55172","XP_016857038.1,-;NP_001289959.1,uncharacterized protein C1orf109 isoform 2;XP_016857037.1,-","PF15011,Casein Kinase 2 substrate","IPR029159,Casein Kinase 2 substrate","ENOG410IGVE,-;ENOG41127GW,-","-","-"]
["ANKRD22",8.358377878,3.970532225,1.070115962,3.515314118,0.008680466,0.016808416,"ENSG00000152766","G1RNL5,Ankyrin repeat domain 22","XP_003255230.1,-","PF12796,Ankyrin repeats (3 copies);PF13857,Ankyrin repeats (many copies)","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["HKR1",2.010977213,0.955287012,1.070115962,3.515314118,0.008680466,0.016808416,"ENSG00000181666","G3RBG2,HKR1, GLI-Kruppel zinc finger family member","XP_018871794.1,Krueppel-related zinc finger protein 1 isoform X1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["DESI1",2.913328412,1.383936514,1.070115962,3.515314118,0.008680466,0.016808416,"ENSG00000100418","A0A1S3FVI6,desumoylating isopeptidase 1 isoform X1","XP_012880400.1,-","-","IPR008580,PPPDE putative peptidase domain","-","-","-"]
["SPCS3",8.968630871,4.26907431,1.070072982,5.524945545,{"v":7.46e-05,"d":"7.46E-05"},2.32399E-4,"ENSG00000129128","I3MLG9,Signal peptidase complex subunit 3","XP_005325591.1,-","PF04573,Signal peptidase subunit","IPR007653,Signal peptidase complex subunit 3","KOG3372,Signal peptidase complex subunit;ENOG4110TZP,-","GO:0006508,biological_process,proteolysis;GO:0005787,cellular_component,signal peptidase complex;GO:0006465,biological_process,signal peptide processing;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0008233,molecular_function,peptidase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["NPC1",3.408406362,1.621775119,1.069937201,4.712243769,0.000567173,0.001450194,"ENSG00000141458","A0A193DRS0,Niemann-Pick C1","-","PF02460,Patched family;PF12349,Sterol-sensing domain of SREBP cleavage-activation;PF16414,Niemann-Pick C1 N terminus","IPR000731,Sterol-sensing domain;IPR004765,NPC1-like;IPR032190,Niemann-Pick C1, N-terminal;IPR003392,Protein patched/dispatched","-","GO:0006869,biological_process,lipid transport;GO:0005319,molecular_function,lipid transporter activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["PSMD12",13.85626873,6.597250572,1.069867397,5.799431297,{"v":4.26e-05,"d":"4.26E-05"},1.40722E-4,"ENSG00000197170","H2NUI3,26S proteasome non-ATPase regulatory subunit 12","-","PF01399,PCI domain","IPR036390,Winged helix DNA-binding domain superfamily;IPR000717,Proteasome component (PCI) domain;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR035297,26S Proteasome non-ATPase regulatory subunit 12","COG5071,26S proteasome regulatory complex component;KOG1498,26S proteasome regulatory complex, subunit RPN5/PSMD12","GO:0022624,cellular_component,proteasome accessory complex;GO:0000502,cellular_component,proteasome complex;GO:0005838,cellular_component,proteasome regulatory particle","-"]
["PTHLH",14.06337846,6.694929734,1.06965289,5.164760936,0.000199486,0.000566396,"ENSG00000087494","G1R0M9,Parathyroid hormone like hormone","-","PF01279,Parathyroid hormone family","IPR003626,Parathyroid hormone-related protein;IPR001415,Parathyroid hormone/parathyroid hormone-related protein","ENOG41126XH,-;ENOG410IW2I,-","GO:0005794,cellular_component,Golgi apparatus;GO:0001501,biological_process,skeletal system development;GO:0030819,biological_process,positive regulation of cAMP biosynthetic process;GO:0007189,biological_process,adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0030282,biological_process,bone mineralization;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0051428,molecular_function,peptide hormone receptor binding;GO:0005179,molecular_function,hormone activity;GO:0010468,biological_process,regulation of gene expression;GO:0005829,cellular_component,cytosol;GO:0032331,biological_process,negative regulation of chondrocyte differentiation;GO:0005576,cellular_component,extracellular region;GO:0005654,cellular_component,nucleoplasm","-"]
["DHX40",10.19571259,4.855090616,1.069491179,5.50854191,{"v":7.63e-05,"d":"7.63E-05"},2.37152E-4,"ENSG00000108406","K7B4G4,DEAH","-","PF00271,Helicase conserved C-terminal domain;PF04408,Helicase associated domain (HA2);PF00270,AD/DEAH box helicase;PF07717,Oligonucleotide/oligosaccharide-binding (OB)-fold","IPR011709,Domain of unknown function DUF1605;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR007502,Helicase-associated domain;IPR011545,DEAD/DEAH box helicase domain;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR001650,Helicase, C-terminal","KOG0922,DEAH-box RNA helicase;COG1643,HrpA-like helicases","GO:0003676,molecular_function,nucleic acid binding;GO:0004386,molecular_function,helicase activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016787,molecular_function,hydrolase activity","-"]
["SPRY4",5.686229449,2.707505701,1.068890288,4.683263851,0.00069414,0.001737835,"ENSG00000187678","A0A0C4DFS6,Protein sprouty homolog 4","NP_112226.2,protein sprouty homolog 4 isoform 1;XP_011535987.1,-","PF05210,Sprouty protein (Spry)","IPR007875,Sprouty;IPR030790,Protein sprouty homologue 4","ENOG410ZPNT,-;ENOG410IH70,-","GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0016020,cellular_component,membrane;GO:0009966,biological_process,regulation of signal transduction;GO:0043407,biological_process,negative regulation of MAP kinase activity;GO:0007275,biological_process,multicellular organism development","-"]
["DNMT3B",4.461994091,2.123089277,1.068882351,4.001851173,0.003378543,0.007224409,"ENSG00000088305","G3R276,DNA methyltransferase 3 beta","XP_004062033.1,DNA (cytosine-5)-methyltransferase 3B isoform X1","PF00145,C-5 cytosine-specific DNA methylase;PF00855,PWWP domain","IPR001525,C-5 cytosine methyltransferase;IPR011011,Zinc finger, FYVE/PHD-type;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR018117,DNA methylase, C-5 cytosine-specific, active site;IPR000313,PWWP domain;IPR025766,ADD domain;IPR030488,DNA (cytosine-5)-methyltransferase 3B, ADD domain","-","GO:0051571,biological_process,positive regulation of histone H3-K4 methylation;GO:0090116,biological_process,C-5 methylation of cytosine;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0009008,molecular_function,DNA-methyltransferase activity;GO:0006306,biological_process,DNA methylation;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0032259,biological_process,methylation;GO:0003714,molecular_function,transcription corepressor activity;GO:0008168,molecular_function,methyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0051573,biological_process,negative regulation of histone H3-K9 methylation;GO:0010468,biological_process,regulation of gene expression;GO:0010628,biological_process,positive regulation of gene expression;GO:0005654,cellular_component,nucleoplasm;GO:0005634,cellular_component,nucleus;GO:0003886,molecular_function,DNA (cytosine-5-)-methyltransferase activity","K17399,ko05206,MicroRNAs in cancer;K17399,ko00270,Cysteine and methionine metabolism"]
["WWOX",1.555203571,0.737678652,1.068847252,2.656023735,0.044449271,0.070760917,"ENSG00000186153","A8K5I5,cDNA FLJ78250, highly similar to Homo sapiens WW domain containing oxidoreductase","-","PF00397,WW domain;PF08659,KR domain;PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily;IPR001202,WW domain;IPR036020,WW domain superfamily;IPR002347,Short-chain dehydrogenase/reductase SDR","COG5021,Ubiquitin-protein ligase;ENOG410INSS,-","-","-"]
["RP11-703M24.5",7.243779456,3.435936984,1.068847252,2.656023735,0.044449271,0.070760917,"ENSG00000266049","A0A1A9AGJ1,Uncharacterized protein","-","-","-","-","-","-"]
["ZNF718",1.845246394,0.875254467,1.068847252,2.656023735,0.044449271,0.070760917,"ENSG00000250312","A8WFQ3,Zinc finger protein 718","-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["CDT1",8.043464154,3.830597829,1.06821613,4.36444049,1.586091E-3,3.668962E-3,"ENSG00000167513","G3RA62,Chromatin licensing and DNA replication factor 1","-","PF08839,NA replication factor CDT1 like;PF16679,NA replication factor Cdt1 C-terminal domain","-","-","-","-"]
["TAOK2",5.085810133,2.423653215,1.068111661,5.122246532,0.000193705,0.00055232,"ENSG00000149930","K7CMN1,TAO kinase 2","XP_510917.3,serine/threonine-protein kinase TAO2 isoform X1","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410Y259,-;KOG0577,Serine/threonine protein kinase","GO:0007409,biological_process,axonogenesis;GO:0031434,molecular_function,mitogen-activated protein kinase kinase binding;GO:0007095,biological_process,mitotic G2 DNA damage checkpoint;GO:0004672,molecular_function,protein kinase activity;GO:0000186,biological_process,activation of MAPKK activity;GO:0005524,molecular_function,ATP binding;GO:0043005,cellular_component,neuron projection;GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0150019,biological_process,basal dendrite morphogenesis;GO:0016310,biological_process,phosphorylation;GO:0044294,cellular_component,dendritic growth cone;GO:0005829,cellular_component,cytosol;GO:0043235,cellular_component,receptor complex;GO:0046330,biological_process,positive regulation of JNK cascade;GO:0016021,cellular_component,integral component of membrane;GO:0044295,cellular_component,axonal growth cone;GO:0030036,biological_process,actin cytoskeleton organization;GO:0032874,biological_process,positive regulation of stress-activated MAPK cascade;GO:0015629,cellular_component,actin cytoskeleton;GO:0030424,cellular_component,axon;GO:0005634,cellular_component,nucleus;GO:0150020,biological_process,basal dendrite arborization;GO:0016020,cellular_component,membrane;GO:0008360,biological_process,regulation of cell shape;GO:0048041,biological_process,focal adhesion assembly;GO:0038191,molecular_function,neuropilin binding;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0005730,cellular_component,nucleolus;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0051403,biological_process,stress-activated MAPK cascade;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["DSP",24.23302781,11.55733543,1.067943226,7.50362659,{"v":1.98e-06,"d":"1.98E-06"},{"v":8.82e-06,"d":"8.82E-06"},"ENSG00000096696","H2QS97,Desmoplakin","XP_518227.3,desmoplakin isoform X1","PF00681,Plectin repeat","IPR035915,Plakin repeat superfamily;IPR018159,Spectrin/alpha-actinin;IPR001101,Plectin repeat;IPR028462,Desmoplakin","ENOG4111ACS,-;ENOG410IQBR,-","GO:0071896,biological_process,protein localization to adherens junction;GO:0098609,biological_process,cell-cell adhesion;GO:0014704,cellular_component,intercalated disc;GO:0005856,cellular_component,cytoskeleton;GO:0005886,cellular_component,plasma membrane;GO:0005198,molecular_function,structural molecule activity;GO:0097110,molecular_function,scaffold protein binding;GO:0043588,biological_process,skin development;GO:0050839,molecular_function,cell adhesion molecule binding;GO:0030057,cellular_component,desmosome;GO:0001533,cellular_component,cornified envelope;GO:0016323,cellular_component,basolateral plasma membrane;GO:0002934,biological_process,desmosome organization;GO:0030054,cellular_component,cell junction;GO:0034332,biological_process,adherens junction organization;GO:0045109,biological_process,intermediate filament organization;GO:0098911,biological_process,regulation of ventricular cardiac muscle cell action potential;GO:0005882,cellular_component,intermediate filament;GO:0045104,biological_process,intermediate filament cytoskeleton organization;GO:0005911,cellular_component,cell-cell junction;GO:0003223,biological_process,ventricular compact myocardium morphogenesis;GO:0030674,molecular_function,protein binding, bridging;GO:0086073,biological_process,bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0086091,biological_process,regulation of heart rate by cardiac conduction;GO:0030216,biological_process,keratinocyte differentiation;GO:0018149,biological_process,peptide cross-linking;GO:0005080,molecular_function,protein kinase C binding","-"]
["ABCC4",1.761438602,0.838121103,1.067566841,3.447618463,0.012050518,0.022476702,"ENSG00000125257","H2Q7Q1,ATP binding cassette subfamily C member 4","XP_001137006.1,multidrug resistance-associated protein 4 isoform X1","PF00005,ABC transporter;PF00664,ABC transporter transmembrane region","IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR030240,Multidrug resistance-associated protein 4;IPR011527,ABC transporter type 1, transmembrane domain;IPR036640,ABC transporter type 1, transmembrane domain superfamily;IPR003593,AAA+ ATPase domain;IPR017871,ABC transporter, conserved site","COG1132,ABC-type multidrug transport system, ATPase and permease components;KOG0054,Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily","GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0031088,cellular_component,platelet dense granule membrane;GO:0032310,biological_process,prostaglandin secretion;GO:0055085,biological_process,transmembrane transport;GO:0000166,molecular_function,nucleotide binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016323,cellular_component,basolateral plasma membrane;GO:0016887,molecular_function,ATPase activity;GO:0016020,cellular_component,membrane;GO:0005886,cellular_component,plasma membrane;GO:0060271,biological_process,cilium assembly;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","K05673,ko04024,cAMP signaling pathway;K05673,ko02010,ABC transporters;K05673,ko04976,Bile secretion"]
["ATP10D",1.729151089,0.82275818,1.067566841,3.447618463,0.012050518,0.022476702,"ENSG00000145246","H2QPF0,Phospholipid-transporting ATPase","-","PF13246,Cation transport ATPase (P-type);PF16209,Phospholipid-translocating ATPase N-terminal;PF00122,1-E2 ATPase;PF16212,Phospholipid-translocating P-type ATPase C-terminal","-","-","-","-"]
["IDS",7.615488947,3.63208511,1.067369608,5.730397676,{"v":5.23e-05,"d":"5.23E-05"},1.69178E-4,"ENSG00000010404","K7BKV4,Iduronate 2-sulfatase","XP_016799854.1,iduronate 2-sulfatase isoform X1","PF00884,Sulfatase","IPR035874,Iduronate-2-sulfatase;IPR024607,Sulfatase, conserved site;IPR000917,Sulfatase, N-terminal;IPR017850,Alkaline-phosphatase-like, core domain superfamily;IPR017849,Alkaline phosphatase-like, alpha/beta/alpha","-","GO:0008484,molecular_function,sulfuric ester hydrolase activity;GO:0003824,molecular_function,catalytic activity;GO:0004423,molecular_function,iduronate-2-sulfatase activity;GO:0008152,biological_process,metabolic process","K01136,ko04142,Lysosome;K01136,ko00531,Glycosaminoglycan degradation"]
["TMCO3",3.696410448,1.763154888,1.066552291,4.868872558,0.000415026,0.001095278,"ENSG00000150403","A0A024RE09,Testis tissue sperm-binding protein Li 36a","XP_006720032.1,-;NP_060375.4,transmembrane and coiled-coil domain-containing protein 3 isoform 1 precursor;XP_011535800.1,-","PF00999,Sodium/hydrogen exchanger family","IPR006153,Cation/H+ exchanger","KOG1650,Predicted K+/H+-antiporter;COG0475,Kef-type K+ transport systems, membrane components","GO:0055085,biological_process,transmembrane transport;GO:0015299,molecular_function,solute:proton antiporter activity;GO:0006812,biological_process,cation transport;GO:1902600,biological_process,proton transmembrane transport;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["TXLNG",10.00953079,4.77536411,1.066473936,5.078437518,0.000269813,0.000742367,"ENSG00000086712","H2PV06,Taxilin gamma","-","PF09728,Myosin-like coiled-coil protein","IPR026183,Taxilin family","KOG1850,Myosin-like coiled-coil protein;ENOG410XQH1,-","GO:0019905,molecular_function,syntaxin binding;GO:0030500,biological_process,regulation of bone mineralization;GO:0010564,biological_process,regulation of cell cycle process;GO:0051726,biological_process,regulation of cell cycle;GO:0046982,molecular_function,protein heterodimerization activity;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol","-"]
["DFFA",11.29567287,5.39343333,1.065768367,5.809769102,{"v":4.19e-05,"d":"4.19E-05"},1.38424E-4,"ENSG00000160049","Q53HN4,DNAation factor, 45kDa, alpha polypeptide isoform 1 variant","-","PF02017,CIDE-N domain;PF09033,NA Fragmentation factor 45kDa, C terminal domain","IPR015121,DNA fragmentation factor 45kDa, middle domain;IPR003508,CIDE-N domain;IPR017299,DNA fragmentation factor subunit alpha;IPR027296,DNA fragmentation factor 45kDa, C-terminal","ENOG410IU5B,-;ENOG4111HKY,-","GO:0006915,biological_process,apoptotic process;GO:0005622,cellular_component,intracellular","-"]
["USP7",19.36869048,9.251383504,1.065633663,6.844096256,{"v":5.35e-06,"d":"5.35E-06"},{"v":2.16E-5,"d":"2.16E-05"},"ENSG00000187555","K7BZY2,Ubiquitin specific peptidase 7","-","PF00917,MATH domain;PF14533,Ubiquitin-specific protease C-terminal;PF00443,Ubiquitin carboxyl-terminal hydrolase;PF12436,ICP0-binding domain of Ubiquitin-specific protease 7","IPR018200,Ubiquitin specific protease, conserved site;IPR008974,TRAF-like;IPR024729,Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain;IPR002083,MATH/TRAF domain;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase;IPR029346,Ubiquitin carboxyl-terminal hydrolase, C-terminal","KOG1863,Ubiquitin carboxyl-terminal hydrolase;COG5077,Ubiquitin carboxyl-terminal hydrolase","GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016579,biological_process,protein deubiquitination","-"]
["CHMP6",14.91133112,7.116392103,1.065471777,4.592642498,0.000850693,0.002087239,"ENSG00000176108","I3L4A1,Charged multivesicular body protein 6","-","PF03357,Snf7","IPR005024,Snf7 family","ENOG4111HN3,-;KOG2910,Uncharacterized conserved protein predicted to be involved in protein sorting","GO:0007034,biological_process,vacuolar transport","-"]
["HMCES",9.129800771,4.356287268,1.065347173,4.289414396,0.002146184,0.004813734,"ENSG00000183624","H2R0W0,Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein","XP_016797360.1,-;XP_016797359.1,embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein","PF02586,SOS response associated peptidase (SRAP)","IPR003738,SOS response associated peptidase (SRAP);IPR036590,SOS response associated peptidase-like","KOG2618,Uncharacterized conserved protein;COG2135,Uncharacterized conserved protein","GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0008233,molecular_function,peptidase activity","-"]
["GDAP1",6.270541842,2.991990984,1.065347173,4.289414396,0.002146184,0.004813734,"ENSG00000104381","G3QK24,Ganglioside induced differentiation associated protein 1","XP_004047211.1,-","PF13410,lutathione S-transferase, C-terminal domain;PF13417,lutathione S-transferase, N-terminal domain","IPR004045,Glutathione S-transferase, N-terminal;IPR036282,Glutathione S-transferase, C-terminal domain superfamily;IPR010987,Glutathione S-transferase, C-terminal-like;IPR034336,Ganglioside-induced differentiation-associated protein 1;IPR036249,Thioredoxin-like superfamily","-","GO:0008053,biological_process,mitochondrial fusion;GO:0032526,biological_process,response to retinoic acid;GO:0031307,cellular_component,integral component of mitochondrial outer membrane;GO:0000266,biological_process,mitochondrial fission;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0005829,cellular_component,cytosol;GO:0006626,biological_process,protein targeting to mitochondrion;GO:0005739,cellular_component,mitochondrion","-"]
["LINC00847",7.841121797,3.740145317,1.065142741,3.904493624,0.004823037,0.009930544,"-","-","-","-","-","-","-","-"]
["IGBP1-AS2",37.49370715,17.88416464,1.065142741,3.904493624,0.004823037,0.009930544,"ENSG00000220925","G7NBX0,Uncharacterized protein","-","-","-","-","-","-"]
["WWC2",5.575524182,2.663128542,1.065008986,5.388165522,1.16564E-4,0.000347254,"ENSG00000151718","H2PET6,WW and C2 domain containing 2","XP_002815374.1,protein WWC2","PF00397,WW domain","IPR036020,WW domain superfamily;IPR001202,WW domain;IPR037771,WWC, C2 domain;IPR035892,C2 domain superfamily","KOG3209,WW domain-containing protein;COG5021,Ubiquitin-protein ligase","GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0046621,biological_process,negative regulation of organ growth;GO:0019900,molecular_function,kinase binding;GO:0035331,biological_process,negative regulation of hippo signaling;GO:0005829,cellular_component,cytosol;GO:0032947,molecular_function,protein-containing complex scaffold activity","-"]
["GALNT13",7.575415678,3.618369332,1.064887068,5.221616364,0.000159897,0.00046281,"ENSG00000144278","G7N843,Polypeptide N-acetylgalactosaminyltransferase","-","PF00535,lycosyl transferase family 2;PF00652,Ricin-type beta-trefoil lectin domain","IPR035992,Ricin B-like lectins;IPR000772,Ricin B, lectin domain;IPR029044,Nucleotide-diphospho-sugar transferases;IPR001173,Glycosyltransferase 2-like","-","GO:0005794,cellular_component,Golgi apparatus;GO:0006486,biological_process,protein glycosylation;GO:0016740,molecular_function,transferase activity;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0030246,molecular_function,carbohydrate binding;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ARRB1",2.240958818,1.068223311,1.06474562,3.376552256,0.016842613,0.030237414,"ENSG00000137486","G3R2M1,Arrestin beta 1","XP_004051870.1,-","PF00339,Arrestin (or S-antigen), N-terminal domain;PF02752,Arrestin (or S-antigen), C-terminal domain","IPR011022,Arrestin C-terminal-like domain;IPR014753,Arrestin, N-terminal;IPR011021,Arrestin-like, N-terminal;IPR014752,Arrestin, C-terminal;IPR000698,Arrestin;IPR017864,Arrestin, conserved site;IPR014756,Immunoglobulin E-set","-","GO:0031397,biological_process,negative regulation of protein ubiquitination;GO:0000785,cellular_component,chromatin;GO:0033138,biological_process,positive regulation of peptidyl-serine phosphorylation;GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0008134,molecular_function,transcription factor binding;GO:0005096,molecular_function,GTPase activator activity;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0090240,biological_process,positive regulation of histone H4 acetylation;GO:0005634,cellular_component,nucleus;GO:0031434,molecular_function,mitogen-activated protein kinase kinase binding;GO:0031701,molecular_function,angiotensin receptor binding;GO:0016567,biological_process,protein ubiquitination;GO:0043149,biological_process,stress fiber assembly;GO:0032092,biological_process,positive regulation of protein binding;GO:1990763,molecular_function,arrestin family protein binding;GO:0031143,cellular_component,pseudopodium;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0008277,biological_process,regulation of G-protein coupled receptor protein signaling pathway;GO:0002092,biological_process,positive regulation of receptor internalization;GO:0005829,cellular_component,cytosol;GO:0006915,biological_process,apoptotic process;GO:0035066,biological_process,positive regulation of histone acetylation;GO:0002031,biological_process,G-protein coupled receptor internalization;GO:0042981,biological_process,regulation of apoptotic process;GO:0070374,biological_process,positive regulation of ERK1 and ERK2 cascade;GO:0043027,molecular_function,cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0032717,biological_process,negative regulation of interleukin-8 production;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0016604,cellular_component,nuclear body;GO:0007165,biological_process,signal transduction;GO:0005654,cellular_component,nucleoplasm;GO:0007602,biological_process,phototransduction;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0032715,biological_process,negative regulation of interleukin-6 production;GO:0005159,molecular_function,insulin-like growth factor receptor binding;GO:0035025,biological_process,positive regulation of Rho protein signal transduction;GO:0045746,biological_process,negative regulation of Notch signaling pathway;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0005737,cellular_component,cytoplasm;GO:0005622,cellular_component,intracellular;GO:0035774,biological_process,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0001934,biological_process,positive regulation of protein phosphorylation","-"]
["TRAPPC13",1.852788763,0.883189879,1.06474562,3.376552256,0.016842613,0.030237414,"ENSG00000113597","M3ZA02,Trafficking protein particle complex 13","XP_012352788.1,trafficking protein particle complex subunit 13 isoform X4","PF06159,Protein of unknown function (DUF974)","IPR010378,Protein of unknown function DUF974","KOG2625,Uncharacterized conserved protein;ENOG410XSJK,-","-","-"]
["TERF2",7.688622388,3.672442099,1.064730359,5.03325238,3.31856E-4,0.000894267,"ENSG00000132604","F6TW69,Telomeric repeat binding factor 2","XP_014981983.1,-","PF16772,Telomeric repeat-binding factor 2 Rap1-binding motif;PF08558,Telomere repeat binding factor (TRF);PF00249,Myb-like DNA-binding domain","IPR009057,Homeobox-like domain superfamily;IPR017357,Telomeric repeat-binding factor 1/2;IPR017930,Myb domain;IPR013867,Telomere repeat-binding factor, dimerisation domain;IPR036507,Telomere repeat-binding factor, dimerisation domain superfamily;IPR031902,Telomeric repeat-binding factor 2, Rap1-binding domain;IPR030657,Telomeric repeat-binding factor 2;IPR001005,SANT/Myb domain","ENOG410IJXM,-;ENOG4111KJ3,-","GO:1905839,biological_process,negative regulation of telomeric D-loop disassembly;GO:1904430,biological_process,negative regulation of t-circle formation;GO:0098505,molecular_function,G-rich strand telomeric DNA binding;GO:1904357,biological_process,negative regulation of telomere maintenance via telomere lengthening;GO:0070187,cellular_component,shelterin complex;GO:0070198,biological_process,protein localization to chromosome, telomeric region;GO:0031848,biological_process,protection from non-homologous end joining at telomere;GO:0000783,cellular_component,nuclear telomere cap complex;GO:0003691,molecular_function,double-stranded telomeric DNA binding;GO:0006278,biological_process,RNA-dependent DNA biosynthetic process;GO:0032204,biological_process,regulation of telomere maintenance;GO:0010628,biological_process,positive regulation of gene expression;GO:0016233,biological_process,telomere capping;GO:0051000,biological_process,positive regulation of nitric-oxide synthase activity;GO:0005634,cellular_component,nucleus;GO:0032210,biological_process,regulation of telomere maintenance via telomerase;GO:0061820,biological_process,telomeric D-loop disassembly;GO:0042803,molecular_function,protein homodimerization activity;GO:0044877,molecular_function,protein-containing complex binding;GO:1905778,biological_process,negative regulation of exonuclease activity;GO:0010629,biological_process,negative regulation of gene expression;GO:0031627,biological_process,telomeric loop formation;GO:0000723,biological_process,telomere maintenance;GO:1903770,biological_process,negative regulation of beta-galactosidase activity;GO:0003677,molecular_function,DNA binding;GO:2000773,biological_process,negative regulation of cellular senescence;GO:0032208,biological_process,negative regulation of telomere maintenance via recombination;GO:0003720,molecular_function,telomerase activity;GO:0008022,molecular_function,protein C-terminus binding;GO:0016604,cellular_component,nuclear body;GO:1904354,biological_process,negative regulation of telomere capping;GO:0019899,molecular_function,enzyme binding;GO:0032211,biological_process,negative regulation of telomere maintenance via telomerase;GO:0000781,cellular_component,chromosome, telomeric region;GO:0000784,cellular_component,nuclear chromosome, telomeric region;GO:0042162,molecular_function,telomeric DNA binding;GO:0030870,cellular_component,Mre11 complex;GO:0032205,biological_process,negative regulation of telomere maintenance","-"]
["TRMT6",17.60827348,8.417201847,1.064025962,5.642938159,{"v":6.65e-05,"d":"6.65E-05"},0.000209492,"ENSG00000089195","H2QJX7,tRNA methyltransferase 6 homolog","XP_001166710.1,tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X1","PF04189,cd10p family","IPR017423,tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6","KOG1416,tRNA(1-methyladenosine) methyltransferase, subunit GCD10;ENOG410XSXD,-","GO:0080009,biological_process,mRNA methylation;GO:0031515,cellular_component,tRNA (m1A) methyltransferase complex;GO:0030488,biological_process,tRNA methylation;GO:0016740,molecular_function,transferase activity;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0008033,biological_process,tRNA processing;GO:0005634,cellular_component,nucleus","-"]
["ELOVL1",16.95467332,8.103364019,1.063815616,5.010116142,0.000273289,0.000751161,"ENSG00000066322","H2PYU9,Elongation of very long chain fatty acids protein 1","XP_009453917.1,-;XP_001173687.1,-;XP_001173622.1,elongation of very long chain fatty acids protein 1 isoform X1","PF01151,NS1/SUR4 family","IPR030457,ELO family, conserved site;IPR002076,ELO family;IPR033681,Elongation of very long chain fatty acids protein 1","ENOG410XRWT,-;KOG3071,Fatty acyl-CoA elongase/Polyunsaturated fatty acid specific elongation enzyme","GO:0006631,biological_process,fatty acid metabolic process;GO:0009922,molecular_function,fatty acid elongase activity;GO:0030148,biological_process,sphingolipid biosynthetic process;GO:0006629,biological_process,lipid metabolic process;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0034625,biological_process,fatty acid elongation, monounsaturated fatty acid;GO:0042761,biological_process,very long-chain fatty acid biosynthetic process;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0006633,biological_process,fatty acid biosynthetic process;GO:0034626,biological_process,fatty acid elongation, polyunsaturated fatty acid;GO:0016020,cellular_component,membrane;GO:0035338,biological_process,long-chain fatty-acyl-CoA biosynthetic process;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0019367,biological_process,fatty acid elongation, saturated fatty acid;GO:0016021,cellular_component,integral component of membrane;GO:0006636,biological_process,unsaturated fatty acid biosynthetic process","K10247,ko00062,Fatty acid elongation"]
["ENTPD4",6.017180918,2.875868289,1.063815616,5.010116142,0.000273289,0.000751161,"ENSG00000197217","H2QVW4,Ectonucleoside triphosphate diphosphohydrolase 4","-","PF01150,A1/CD39 (nucleoside phosphatase) family","IPR000407,Nucleoside phosphatase GDA1/CD39","KOG1386,Nucleoside phosphatase;COG5371,Golgi nucleoside diphosphatase","GO:0016787,molecular_function,hydrolase activity","K12305,ko00240,Pyrimidine metabolism;K12305,ko00230,Purine metabolism;K12305,ko04142,Lysosome"]
["TMEM40",10.19971988,4.875396572,1.063447571,4.789535485,0.000547773,1.407298E-3,"ENSG00000088726","G3RX84,Transmembrane protein 40","XP_004033688.2,transmembrane protein 40 isoform X1","PF15817,Transmembrane protein 40 family","IPR026181,Transmembrane protein 40","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["B4GALNT4",4.924725161,2.352276793,1.063061792,3.853214047,0.006406987,0.012809994,"ENSG00000182272","H9FTV7,Beta-1,4-N-acetylgalactosaminyltransferase","-","PF07691,PA14 domain;PF05679,Chondroitin N-acetylgalactosaminyltransferase","IPR008428,Chondroitin N-acetylgalactosaminyltransferase;IPR011658,PA14 domain;IPR037524,PA14/GLEYA domain;IPR029044,Nucleotide-diphospho-sugar transferases","-","GO:0033842,molecular_function,N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity;GO:0005794,cellular_component,Golgi apparatus;GO:0032580,cellular_component,Golgi cisterna membrane;GO:0016740,molecular_function,transferase activity;GO:0008376,molecular_function,acetylgalactosaminyltransferase activity","-"]
["SLC37A3",1.749328611,0.835560353,1.063061792,3.853214047,0.006406987,0.012809994,"ENSG00000157800","H2QVH6,Solute carrier family 37","-","-","IPR036259,MFS transporter superfamily;IPR000849,Sugar phosphate transporter;IPR020846,Major facilitator superfamily domain;IPR011701,Major facilitator superfamily","ENOG410IP3Z,-;COG2271,Sugar phosphate permease","GO:0055085,biological_process,transmembrane transport;GO:0022857,molecular_function,transmembrane transporter activity;GO:0016021,cellular_component,integral component of membrane","-"]
["OSBPL3",7.270384695,3.478895837,1.062484048,5.4712594,{"v":9.98E-5,"d":"9.98E-05"},0.000301631,"ENSG00000070882","K7CM92,Oxysterol-binding protein","-","PF15409,Pleckstrin homology domain;PF01237,Oxysterol-binding protein","IPR000648,Oxysterol-binding protein;IPR037239,Oxysterol-binding protein superfamily;IPR001849,Pleckstrin homology domain;IPR018494,Oxysterol-binding protein, conserved site;IPR011993,PH-like domain superfamily","KOG1737,Oxysterol-binding protein;ENOG410XP9E,-","GO:0006869,biological_process,lipid transport","-"]
["NABP1",1.737177653,0.830669316,1.062144584,4.21024644,0.002193888,0.004913881,"ENSG00000173559","G1R4X1,Nucleic acid binding protein 1","-","-","-","-","-","-"]
["SAMHD1",4.760515021,2.276343902,1.062144584,4.21024644,0.002193888,0.004913881,"ENSG00000101347","H6WE98,SAM domain and HD domain-containing protein 1","NP_001266115.1,deoxynucleoside triphosphate triphosphohydrolase SAMHD1","PF07647,SAM domain (Sterile alpha motif);PF01966,HD domain","IPR003607,HD/PDEase domain;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain;IPR006674,HD domain","-","GO:0051607,biological_process,defense response to virus;GO:0004540,molecular_function,ribonuclease activity;GO:0032567,molecular_function,dGTP binding;GO:0006203,biological_process,dGTP catabolic process;GO:0003723,molecular_function,RNA binding;GO:0051289,biological_process,protein homotetramerization;GO:0005886,cellular_component,plasma membrane;GO:0045088,biological_process,regulation of innate immune response;GO:0008832,molecular_function,dGTPase activity;GO:0003676,molecular_function,nucleic acid binding;GO:0046061,biological_process,dATP catabolic process;GO:0042802,molecular_function,identical protein binding;GO:0090501,biological_process,RNA phosphodiester bond hydrolysis;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm","-"]
["QSOX2",5.29436527,2.531616022,1.062144584,4.21024644,0.002193888,0.004913881,"ENSG00000165661","K7BNI7,Sulfhydryl oxidase","-","PF00085,Thioredoxin;PF04777,rv1 / Alr family","IPR017905,ERV/ALR sulfhydryl oxidase domain;IPR013766,Thioredoxin domain;IPR036249,Thioredoxin-like superfamily;IPR036774,ERV/ALR sulfhydryl oxidase domain superfamily","KOG1731,FAD-dependent sulfhydryl oxidase/quiescin and related proteins;ENOG410XVJT,-","GO:0045454,biological_process,cell redox homeostasis;GO:0005623,cellular_component,cell;GO:0016491,molecular_function,oxidoreductase activity;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0016972,molecular_function,thiol oxidase activity;GO:0016021,cellular_component,integral component of membrane","-"]
["SCO1",16.3877676,7.847267258,1.062034827,6.963645477,{"v":4.65e-06,"d":"4.65E-06"},{"v":1.9e-05,"d":"1.90E-05"},"ENSG00000133028","K7C047,SCO cytochrome oxidase deficient homolog 1","XP_001164786.2,-","PF02630,SCO1/SenC","IPR017276,Synthesis of cytochrome c oxidase, Sco1/Sco2;IPR036249,Thioredoxin-like superfamily;IPR003782,Copper chaperone SCO1/SenC","COG1999,Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems;KOG2792,Putative cytochrome C oxidase assembly protein","GO:0006878,biological_process,cellular copper ion homeostasis;GO:0031305,cellular_component,integral component of mitochondrial inner membrane;GO:1901799,biological_process,negative regulation of proteasomal protein catabolic process;GO:0072492,cellular_component,host cell mitochondrial intermembrane space;GO:0030016,cellular_component,myofibril;GO:0033617,biological_process,mitochondrial respiratory chain complex IV assembly;GO:0046872,molecular_function,metal ion binding;GO:0008535,biological_process,respiratory chain complex IV assembly;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0005507,molecular_function,copper ion binding;GO:0006825,biological_process,copper ion transport","-"]
["ACTR3",8.632047774,4.133525077,1.061810869,6.28076985,{"v":1.66E-5,"d":"1.66E-05"},{"v":6.04e-05,"d":"6.04E-05"},"ENSG00000115091","A0A091CVZ1,Actin-related protein 3","XP_010604517.1,-","PF00022,Actin","IPR004000,Actin family;IPR020902,Actin/actin-like conserved site;IPR015623,Actin-related protein 3","-","GO:0034314,biological_process,Arp2/3 complex-mediated actin nucleation;GO:0007015,biological_process,actin filament organization;GO:0005524,molecular_function,ATP binding;GO:0005885,cellular_component,Arp2/3 protein complex","-"]
["FBXO31",1.790333124,0.855146007,1.061606271,3.301760267,0.018799458,0.033184125,"ENSG00000283277","G3SDZ2,F-box protein 31","XP_018867701.1,-","PF12937,-box-like","IPR026941,F-box only protein 31","-","GO:0030332,molecular_function,cyclin binding;GO:0019005,cellular_component,SCF ubiquitin ligase complex;GO:0031571,biological_process,mitotic G1 DNA damage checkpoint;GO:0031146,biological_process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0006974,biological_process,cellular response to DNA damage stimulus","-"]
["RDH14",7.780672687,3.716409585,1.061606271,3.301760267,0.018799458,0.033184125,"ENSG00000240857","K7A6S4,Retinol dehydrogenase 14","XP_003308945.1,-","PF08659,KR domain;PF13561,noyl-(Acyl carrier protein) reductase;PF01370,NAD dependent epimerase/dehydratase family;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily;IPR002347,Short-chain dehydrogenase/reductase SDR","-","-","-"]
["ZNF395",14.81320377,7.094963753,1.061390163,6.013035333,{"v":2.81e-05,"d":"2.81E-05"},{"v":9.67e-05,"d":"9.67E-05"},"ENSG00000186918","G1S3T3,Zinc finger protein 395","XP_003272967.1,zinc finger protein 395;XP_012364001.1,-","PF15997,omain of unknown function (DUF4772)","IPR013087,Zinc finger C2H2-type;IPR031940,Domain of unknown function DUF4772","ENOG4111TEU,-;ENOG410II8D,-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0001158,molecular_function,enhancer sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0005829,cellular_component,cytosol;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus","-"]
["PRPS2",12.65650521,6.059041225,1.06117101,4.734101778,6.30012E-4,0.001590397,"ENSG00000101911","F6S8U8,Phosphoribosyl pyrophosphate synthetase 2","-","PF13793,N-terminal domain of ribose phosphate pyrophosphokinase;PF14572,Phosphoribosyl synthetase-associated domain","IPR029099,Ribose-phosphate pyrophosphokinase, N-terminal domain;IPR000836,Phosphoribosyltransferase domain;IPR005946,Ribose-phosphate pyrophosphokinase;IPR037515,Ribose-phosphate pyrophosphokinase, bacterial-type;IPR000842,Phosphoribosyl pyrophosphate synthetase, conserved site;IPR029057,Phosphoribosyltransferase-like","COG0462,Phosphoribosylpyrophosphate synthetase;KOG1448,Ribose-phosphate pyrophosphokinase","GO:0009165,biological_process,nucleotide biosynthetic process;GO:0009116,biological_process,nucleoside metabolic process;GO:0000287,molecular_function,magnesium ion binding;GO:0009156,biological_process,ribonucleoside monophosphate biosynthetic process;GO:0044249,biological_process,cellular biosynthetic process;GO:0004749,molecular_function,ribose phosphate diphosphokinase activity","-"]
["RP11-575L7.8",161.3511244,77.29496653,1.060899815,5.565765874,{"v":8.43e-05,"d":"8.43E-05"},0.000258747,"-","-","-","-","-","-","-","-"]
["SFMBT1",3.137686909,1.500924872,1.060818053,3.800028465,0.005047699,0.010363948,"ENSG00000163935","A0A024R338,Scm-like with four mbt domains 1, isoform CRA_b","XP_006713267.1,-;NP_057413.2,scm-like with four MBT domains protein 1;XP_005265278.1,-;XP_006713266.1,-;XP_011532126.1,-;XP_011532127.1,-","PF02820,mbt repeat;PF00536,SAM domain (Sterile alpha motif);PF12140,SLED domain","IPR013761,Sterile alpha motif/pointed domain superfamily;IPR004092,Mbt repeat;IPR038348,SLED domain superfamily;IPR037604,Scm-like with four MBT domains protein 1/2, SAM domain;IPR021987,SLED domain;IPR001660,Sterile alpha motif domain","ENOG410Y4AQ,-;KOG3766,Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans)","GO:0042393,molecular_function,histone binding;GO:1903507,biological_process,negative regulation of nucleic acid-templated transcription;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003714,molecular_function,transcription corepressor activity;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["GMPS",10.23604228,4.904810151,1.060795677,6.089658021,{"v":2.33e-05,"d":"2.33E-05"},{"v":8.14E-5,"d":"8.14E-05"},"ENSG00000163655","A0A140VJK6,Testicular tissue protein Li 82","NP_003866.1,GMP synthase","PF00958,MP synthase C terminal domain;PF00117,lutamine amidotransferase class-I;PF02540,NAD synthase","IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR017926,Glutamine amidotransferase;IPR001674,GMP synthase, C-terminal;IPR025777,GMP synthetase ATP pyrophosphatase domain;IPR004739,GMP synthase, glutamine amidotransferase;IPR022310,NAD/GMP synthase;IPR029062,Class I glutamine amidotransferase-like","-","GO:0016462,molecular_function,pyrophosphatase activity;GO:0006164,biological_process,purine nucleotide biosynthetic process;GO:0005524,molecular_function,ATP binding;GO:0003922,molecular_function,GMP synthase (glutamine-hydrolyzing) activity;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding;GO:0006177,biological_process,GMP biosynthetic process","K01951,ko00230,Purine metabolism;K01951,ko00983,Drug metabolism - other enzymes"]
["P4HA1",7.523793805,3.601861343,1.060399444,4.16896063,0.002824693,0.006139625,"ENSG00000122884","H2NAL0,Prolyl 4-hydroxylase subunit alpha-1","-","PF08336,Prolyl 4-Hydroxylase alpha-subunit, N-terminal region;PF13640,2OG-Fe(II) oxygenase superfamily","IPR013026,Tetratricopeptide repeat-containing domain;IPR019734,Tetratricopeptide repeat;IPR005123,Oxoglutarate/iron-dependent dioxygenase;IPR013547,Prolyl 4-hydroxylase alpha-subunit, N-terminal;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR006620,Prolyl 4-hydroxylase, alpha subunit","KOG1591,Prolyl 4-hydroxylase alpha subunit;ENOG410XS5J,-","GO:0031418,molecular_function,L-ascorbic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0016705,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0005783,cellular_component,endoplasmic reticulum;GO:0019511,biological_process,peptidyl-proline hydroxylation;GO:0016491,molecular_function,oxidoreductase activity;GO:0005739,cellular_component,mitochondrion;GO:0005506,molecular_function,iron ion binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0055114,biological_process,oxidation-reduction process;GO:0042802,molecular_function,identical protein binding;GO:0016702,molecular_function,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004656,molecular_function,procollagen-proline 4-dioxygenase activity","-"]
["CTD-2369P2.5",25.34977586,12.13568315,1.060399444,4.16896063,0.002824693,0.006139625,"ENSG00000266978","K7ELQ0,39S ribosomal protein L4, mitochondrial","-","PF00573,Ribosomal protein L4/L1 family","IPR023574,Ribosomal protein L4 domain superfamily;IPR002136,Ribosomal protein L4/L1e;IPR013005,50S ribosomal protein uL4","KOG1624,Mitochondrial/chloroplast ribosomal protein L4;COG0088,Ribosomal protein L4","GO:0005840,cellular_component,ribosome;GO:0006412,biological_process,translation;GO:0003735,molecular_function,structural constituent of ribosome","-"]
["EXTL3",2.586555289,1.239271729,1.059963118,4.70556185,0.000661048,0.001664306,"ENSG00000012232","H2PPY1,Exostosin like glycosyltransferase 3","XP_009241937.1,exostosin-like 3","PF09258,lycosyl transferase family 64 domain;PF03016,xostosin family","IPR004263,Exostosin-like;IPR029044,Nucleotide-diphospho-sugar transferases;IPR015338,Exostosin , C-terminal","ENOG410XNPM,-;KOG2264,Exostosin EXT1L","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0006486,biological_process,protein glycosylation;GO:0005794,cellular_component,Golgi apparatus;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0015012,biological_process,heparan sulfate proteoglycan biosynthetic process;GO:0016021,cellular_component,integral component of membrane","K02370,ko00534,Glycosaminoglycan biosynthesis - heparan sulfate / heparin"]
["HES1",24.52910327,11.75901791,1.059661828,5.256797513,0.000186241,0.000532736,"ENSG00000114315","G3QZL7,Hes family bHLH transcription factor 1","XP_004038278.1,-","PF00010,Helix-loop-helix DNA-binding domain;PF07527,Hairy Orange","IPR003650,Orange domain;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","-","GO:0045607,biological_process,regulation of inner ear auditory receptor cell differentiation;GO:0021983,biological_process,pituitary gland development;GO:0046983,molecular_function,protein dimerization activity;GO:0021557,biological_process,oculomotor nerve development;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0060122,biological_process,inner ear receptor cell stereocilium organization;GO:0043388,biological_process,positive regulation of DNA binding;GO:0005634,cellular_component,nucleus;GO:0061626,biological_process,pharyngeal arch artery morphogenesis;GO:0071820,molecular_function,N-box binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:2000737,biological_process,negative regulation of stem cell differentiation;GO:0046427,biological_process,positive regulation of JAK-STAT cascade;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:2000974,biological_process,negative regulation of pro-B cell differentiation;GO:0021915,biological_process,neural tube development;GO:2000227,biological_process,negative regulation of pancreatic A cell differentiation;GO:0021537,biological_process,telencephalon development;GO:0048538,biological_process,thymus development;GO:0061106,biological_process,negative regulation of stomach neuroendocrine cell differentiation;GO:0035019,biological_process,somatic stem cell population maintenance;GO:0090102,biological_process,cochlea development;GO:0003281,biological_process,ventricular septum development;GO:0042102,biological_process,positive regulation of T cell proliferation;GO:0042531,biological_process,positive regulation of tyrosine phosphorylation of STAT protein;GO:0035910,biological_process,ascending aorta morphogenesis;GO:0007155,biological_process,cell adhesion;GO:0050767,biological_process,regulation of neurogenesis;GO:0045747,biological_process,positive regulation of Notch signaling pathway;GO:0072141,biological_process,renal interstitial fibroblast development;GO:0046331,biological_process,lateral inhibition;GO:0045665,biological_process,negative regulation of neuron differentiation;GO:0090162,biological_process,establishment of epithelial cell polarity;GO:0045165,biological_process,cell fate commitment;GO:0042826,molecular_function,histone deacetylase binding;GO:0060675,biological_process,ureteric bud morphogenesis;GO:0021558,biological_process,trochlear nerve development;GO:0060716,biological_process,labyrinthine layer blood vessel development;GO:0065003,biological_process,protein-containing complex assembly;GO:0097084,biological_process,vascular smooth muscle cell development;GO:0001889,biological_process,liver development;GO:0001701,biological_process,in utero embryonic development;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0005622,cellular_component,intracellular;GO:0050678,biological_process,regulation of epithelial cell proliferation;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0007224,biological_process,smoothened signaling pathway;GO:0048505,biological_process,regulation of timing of cell differentiation;GO:0021555,biological_process,midbrain-hindbrain boundary morphogenesis;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0045977,biological_process,positive regulation of mitotic cell cycle, embryonic;GO:0048711,biological_process,positive regulation of astrocyte differentiation;GO:0061309,biological_process,cardiac neural crest cell development involved in outflow tract morphogenesis;GO:0048844,biological_process,artery morphogenesis;GO:0042803,molecular_function,protein homodimerization activity;GO:0061009,biological_process,common bile duct development;GO:1903955,biological_process,positive regulation of protein targeting to mitochondrion;GO:0030901,biological_process,midbrain development;GO:0060253,biological_process,negative regulation of glial cell proliferation;GO:0048715,biological_process,negative regulation of oligodendrocyte differentiation;GO:0042491,biological_process,inner ear auditory receptor cell differentiation;GO:0051087,molecular_function,chaperone binding;GO:0060164,biological_process,regulation of timing of neuron differentiation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0035909,biological_process,aorta morphogenesis;GO:0021575,biological_process,hindbrain morphogenesis;GO:0030324,biological_process,lung development;GO:0003151,biological_process,outflow tract morphogenesis;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0031016,biological_process,pancreas development;GO:0060412,biological_process,ventricular septum morphogenesis;GO:0007389,biological_process,pattern specification process;GO:0045596,biological_process,negative regulation of cell differentiation;GO:0045598,biological_process,regulation of fat cell differentiation;GO:0048667,biological_process,cell morphogenesis involved in neuron differentiation;GO:0021984,biological_process,adenohypophysis development;GO:0006351,biological_process,transcription, DNA-templated;GO:0005737,cellular_component,cytoplasm;GO:0003266,biological_process,regulation of secondary heart field cardioblast proliferation;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0072012,biological_process,glomerulus vasculature development;GO:0003677,molecular_function,DNA binding;GO:0042668,biological_process,auditory receptor cell fate determination;GO:0072050,biological_process,S-shaped body morphogenesis;GO:2000981,biological_process,negative regulation of inner ear receptor cell differentiation;GO:0045608,biological_process,negative regulation of inner ear auditory receptor cell differentiation;GO:0072049,biological_process,comma-shaped body morphogenesis;GO:0072282,biological_process,metanephric nephron tubule morphogenesis;GO:0048469,biological_process,cell maturation;GO:0003143,biological_process,embryonic heart tube morphogenesis;GO:0007219,biological_process,Notch signaling pathway;GO:0007262,-,-;GO:0097150,biological_process,neuronal stem cell population maintenance;GO:0030513,biological_process,positive regulation of BMP signaling pathway;GO:0016477,biological_process,cell migration","K06054,ko04950,Maturity onset diabetes of the young;K06054,ko04330,Notch signaling pathway;K06054,ko03460,Fanconi anemia pathway"]
["CEBPG",29.87766507,14.33666853,1.058949305,6.620037622,{"v":8.66e-06,"d":"8.66E-06"},{"v":3.34e-05,"d":"3.34E-05"},"ENSG00000153879","H2NYC5,Uncharacterized protein","-","PF07716,Basic region leucine zipper","IPR004827,Basic-leucine zipper domain","ENOG410ISXZ,-;ENOG41128ZN,-","GO:0016071,biological_process,mRNA metabolic process;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0043433,biological_process,negative regulation of DNA binding transcription factor activity;GO:0005634,cellular_component,nucleus;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045078,biological_process,positive regulation of interferon-gamma biosynthetic process;GO:0006955,biological_process,immune response;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0045739,biological_process,positive regulation of DNA repair;GO:0042267,biological_process,natural killer cell mediated cytotoxicity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005654,cellular_component,nucleoplasm;GO:0043353,biological_process,enucleate erythrocyte differentiation;GO:0030183,biological_process,B cell differentiation;GO:0006357,biological_process,regulation of transcription by RNA polymerase II","-"]
["HMG20B",24.25701251,11.6385512,1.058915273,6.130625123,{"v":2.37E-5,"d":"2.37E-05"},{"v":8.28e-05,"d":"8.28E-05"},"ENSG00000064961","K7CYZ5,High mobility group 20B","XP_016792539.1,-","PF00505,HMG (high mobility group) box","IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily","KOG0381,HMG box-containing protein;COG5648,Chromatin-associated proteins containing the HMG domain","GO:0003677,molecular_function,DNA binding;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0033234,biological_process,negative regulation of protein sumoylation;GO:0046982,molecular_function,protein heterodimerization activity;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["CHURC1",15.29165998,7.336653748,1.058899769,5.953708671,{"v":3.34e-05,"d":"3.34E-05"},1.12827E-4,"ENSG00000258289","A0A024R6B7,Churchill domain containing 1, isoform CRA_b","NP_001190992.1,-","PF06573,Churchill protein","IPR009508,Transcription activator, Churchill;IPR038543,Churchill superfamily","ENOG410IXR5,-;ENOG411208Z,-","GO:0008270,molecular_function,zinc ion binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0007275,biological_process,multicellular organism development","-"]
["PARD6B",5.92896681,2.842615584,1.058641175,4.427610566,0.001184871,0.002819478,"ENSG00000124171","H2P2A5,Par-6 family cell polarity regulator beta","XP_002830461.1,-","PF00595,PDZ domain (Also known as DHR or GLGF);PF00564,PB1 domain","IPR034873,Partitioning defective 6 homologue beta;IPR000270,PB1 domain;IPR036034,PDZ superfamily;IPR034868,Partitioning defective protein 6, PB1 domain;IPR001478,PDZ domain","KOG3606,Cell polarity protein PAR6;ENOG410XRJ3,-","GO:0005923,cellular_component,bicellular tight junction;GO:0007163,biological_process,establishment or maintenance of cell polarity;GO:0007043,biological_process,cell-cell junction assembly;GO:0005938,cellular_component,cell cortex;GO:0016324,cellular_component,apical plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0065003,biological_process,protein-containing complex assembly;GO:0005634,cellular_component,nucleus;GO:0045177,cellular_component,apical part of cell","K06093,ko04015,Rap1 signaling pathway;K06093,ko04530,Tight junction;K06093,ko04360,Axon guidance;K06093,ko04391,Hippo signaling pathway - fly;K06093,ko04390,Hippo signaling pathway;K06093,ko04144,Endocytosis"]
["HMGXB3",3.601902252,1.726471928,1.058546564,4.126450389,0.003035524,0.006541334,"ENSG00000113716","F7BTJ4,HMG-box containing 3","-","PF09011,HMG-box domain","IPR009071,High mobility group box domain;IPR036910,High mobility group box domain superfamily","ENOG410IF99,-;ENOG410XVX8,-","GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus","-"]
["CDC40",2.875400347,1.377663324,1.058391642,3.744788979,0.006790354,0.013477697,"ENSG00000168438","H2QTJ6,Cell division cycle 40 homolog","XP_518687.2,-","PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR032847,Pre-mRNA-processing factor 17;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat","KOG0282,mRNA splicing factor;ENOG410XP87,-","GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0071013,cellular_component,catalytic step 2 spliceosome;GO:0005634,cellular_component,nucleus;GO:0051301,biological_process,cell division;GO:0071007,cellular_component,U2-type catalytic step 2 spliceosome","K12816,ko03040,Spliceosome"]
["HNRNPUL2",41.90209252,20.1191422,1.058211139,7.366273875,{"v":2.82e-06,"d":"2.82E-06"},{"v":1.21e-05,"d":"1.21E-05"},"ENSG00000214753","K7AMR1,Heterogeneous nuclear ribonucleoprotein U-like 2","XP_508499.3,heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X1","PF02037,SAP domain;PF13671,AAA domain;PF00622,SPRY domain","IPR035778,Heterogeneous nuclear ribonucleoprotein U, SPRY domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001870,B30.2/SPRY domain;IPR036361,SAP domain superfamily;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR003877,SPRY domain;IPR003034,SAP domain","ENOG41101YN,-;ENOG410KD8N,-","GO:0005634,cellular_component,nucleus;GO:0030529,,;GO:0005654,cellular_component,nucleoplasm","-"]
["CFH",1.428550905,0.683889327,1.05809176,3.222827835,0.026621608,0.045063799,"ENSG00000000971","A0A024R962,HCG40889, isoform CRA_b","NP_000177.2,complement factor H isoform a precursor","PF00084,Sushi repeat (SCR repeat)","IPR000436,Sushi/SCR/CCP domain;IPR035976,Sushi/SCR/CCP superfamily","ENOG410IVQ9,-;ENOG410YBAR,-","-","K04004,ko04610,Complement and coagulation cascades;K04004,ko05150,Staphylococcus aureus infection"]
["SIL1",12.25486165,5.881767152,1.057939161,5.216951,1.8107E-4,0.000519053,"ENSG00000120725","D6REA1,Nucleotide exchange factor SIL1","-","-","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold","ENOG410Y90B,-;KOG2160,Armadillo/beta-catenin-like repeat-containing protein","-","-"]
["MESDC2",15.80959689,7.5916697,1.05785891,6.471144309,{"v":1.23e-05,"d":"1.23E-05"},{"v":4.58e-05,"d":"4.58E-05"},"ENSG00000117899","H2Q9Y1,Mesoderm development candidate 2","XP_009427940.1,-","PF10185,Chaperone for wingless signalling and trafficking of LDL receptor","IPR019330,LRP chaperone MESD","KOG4357,Uncharacterized conserved protein (involved in mesoderm differentiation in humans);ENOG4111SG4,-","GO:0050750,molecular_function,low-density lipoprotein particle receptor binding;GO:0006909,biological_process,phagocytosis;GO:0006457,biological_process,protein folding;GO:0034394,biological_process,protein localization to cell surface;GO:0005886,cellular_component,plasma membrane;GO:1904395,biological_process,positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0042802,molecular_function,identical protein binding","-"]
["SPAG5-AS1",9.968991758,4.784655261,1.057627177,4.862890542,0.000479246,0.001244756,"ENSG00000227543","H2NT43,KIAA0100","XP_009249705.1,UPF0378 protein KIAA0100 homolog","PF10344,Mitochondrial protein from FMP27;PF10351,olgi-body localisation protein domain;PF10347,RNA pol II promoter Fmp27 protein domain","IPR019439,FMP27, N-terminal;IPR019441,FMP27, GFWDK domain;IPR019443,FMP27,  C-terminal","KOG1910,Uncharacterized conserved protein;ENOG410XSYR,-","-","-"]
["TM9SF3",38.45549076,18.4729215,1.057580718,7.663990553,{"v":1.91e-06,"d":"1.91E-06"},{"v":8.52e-06,"d":"8.52E-06"},"ENSG00000077147","K6ZGA1,Transmembrane 9 superfamily member","XP_016774493.1,-","PF02990,ndomembrane protein 70","IPR004240,Nonaspanin (TM9SF)","KOG1277,Endosomal membrane proteins, EMP70;ENOG410XSVB,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RLIM",12.12948349,5.826692125,1.05724088,6.249246284,{"v":1.87e-05,"d":"1.87E-05"},{"v":6.68e-05,"d":"6.68E-05"},"ENSG00000131263","G3SER0,Ring finger protein, LIM domain interacting","-","PF13639,Ring finger domain","-","-","-","-"]
["SPECC1L",13.03372179,6.263364597,1.056677339,6.16000101,{"v":2.11e-05,"d":"2.11E-05"},{"v":7.5e-05,"d":"7.50E-05"},"ENSG00000100014","B2RMV2,CYTSA protein","NP_001138940.3,cytospin-A isoform 1;NP_056145.4,-","PF00307,Calponin homology (CH) domain","IPR001715,Calponin homology domain;IPR036872,CH domain superfamily","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);KOG4678,FOG: Calponin homology domain","-","-"]
["TAF1B",5.375574155,2.580027127,1.056575648,4.082640546,0.003938964,0.008317773,"ENSG00000115750","G3QJP7,TATA-box binding protein associated factor, RNA polymerase I subunit B","XP_018877012.1,TATA box-binding protein-associated factor RNA polymerase I subunit B","PF11781,Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7","IPR033599,RNA polymerase I transcription initiation factor TAF1B/Rrn7;IPR021752,Transcription initiation factor Rrn7, Zinc-finger","-","GO:0006360,biological_process,transcription by RNA polymerase I;GO:0001188,biological_process,RNA polymerase I transcriptional preinitiation complex assembly;GO:0070860,cellular_component,RNA polymerase I core factor complex;GO:0001164,molecular_function,RNA polymerase I CORE element sequence-specific DNA binding","-"]
["ARF6",50.44108131,24.24624717,1.056562627,7.181764019,{"v":3.67E-6,"d":"3.67E-06"},{"v":1.54e-05,"d":"1.54E-05"},"ENSG00000165527","A0A250YB39,ADP-ribosylation factor 6","XP_020029921.1,-;XP_020029931.1,-","-","IPR006689,Small GTPase superfamily, ARF/SAR type;IPR005225,Small GTP-binding protein domain;IPR024156,Small GTPase superfamily, ARF type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005525,molecular_function,GTP binding;GO:0000166,molecular_function,nucleotide binding;GO:0005622,cellular_component,intracellular","K07941,ko04144,Endocytosis;K07941,ko04014,Ras signaling pathway;K07941,ko04072,Phospholipase D signaling pathway;K07941,ko04666,Fc gamma R-mediated phagocytosis"]
["PFKP",18.60988318,8.943667235,1.056534585,6.076035108,{"v":2.56e-05,"d":"2.56E-05"},{"v":8.88e-05,"d":"8.88E-05"},"ENSG00000067057","K7C3C5,ATP-dependent 6-phosphofructokinase","XP_016818044.1,ATP-dependent 6-phosphofructokinase, platelet type isoform X2","PF00365,Phosphofructokinase","IPR022953,ATP-dependent 6-phosphofructokinase;IPR035966,Phosphofructokinase superfamily;IPR009161,ATP-dependent 6-phosphofructokinase, eukaryotic-type;IPR015912,Phosphofructokinase, conserved site;IPR000023,Phosphofructokinase domain","COG0205,6-phosphofructokinase;KOG2440,Pyrophosphate-dependent phosphofructo-1-kinase","GO:0016301,molecular_function,kinase activity;GO:0006096,biological_process,glycolytic process;GO:0005737,cellular_component,cytoplasm;GO:0006002,biological_process,fructose 6-phosphate metabolic process;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0003872,molecular_function,6-phosphofructokinase activity;GO:0005524,molecular_function,ATP binding;GO:0008152,biological_process,metabolic process;GO:0061615,biological_process,glycolytic process through fructose-6-phosphate;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation","-"]
["XRN2",51.54066581,24.78687685,1.055832193,7.044620357,{"v":4.82e-06,"d":"4.82E-06"},{"v":1.97e-05,"d":"1.97E-05"},"ENSG00000088930","B3KMC9,cDNA FLJ10711 fis, clone NT2RP3000917, highly similar to 5'-3' exoribonuclease 2","-","PF03159,XRN 5'-3' exonuclease N-terminus","IPR027073,5'-3' exoribonuclease;IPR017151,5'-3' exoribonuclease type 2;IPR004859,Putative 5-3 exonuclease","KOG2044,5'-3' exonuclease HKE1/RAT1;COG5049,5'-3' exonuclease","GO:0090503,biological_process,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0004527,molecular_function,exonuclease activity;GO:0005634,cellular_component,nucleus;GO:0004534,molecular_function,5'-3' exoribonuclease activity;GO:0016787,molecular_function,hydrolase activity;GO:0004518,molecular_function,nuclease activity;GO:0003676,molecular_function,nucleic acid binding;GO:0006397,biological_process,mRNA processing;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0006139,biological_process,nucleobase-containing compound metabolic process","-"]
["DHRS3",83.92448481,40.36433744,1.055800284,7.566256143,{"v":2.33e-06,"d":"2.33E-06"},{"v":1.02e-05,"d":"1.02E-05"},"ENSG00000162496","G3RG93,Dehydrogenase/reductase 3","XP_018866893.1,-","PF02719,Polysaccharide biosynthesis protein;PF08659,KR domain;PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily;IPR002347,Short-chain dehydrogenase/reductase SDR;IPR032969,Short-chain dehydrogenase/reductase 3","-","GO:0004745,molecular_function,retinol dehydrogenase activity;GO:0001523,biological_process,retinoid metabolic process;GO:0003151,biological_process,outflow tract morphogenesis;GO:0060021,biological_process,roof of mouth development;GO:0030278,biological_process,regulation of ossification;GO:0060411,biological_process,cardiac septum morphogenesis;GO:0048387,biological_process,negative regulation of retinoic acid receptor signaling pathway;GO:0042572,biological_process,retinol metabolic process;GO:0016020,cellular_component,membrane;GO:0060349,biological_process,bone morphogenesis;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane","-"]
["GIGYF2",18.99185569,9.134326808,1.055800284,7.566256143,{"v":2.33e-06,"d":"2.33E-06"},{"v":1.02e-05,"d":"1.02E-05"},"ENSG00000204120","I1E4Y6,GRB10-interacting GYF protein 2","-","PF02213,YF domain","IPR035445,GYF-like domain superfamily;IPR003169,GYF domain","KOG1862,GYF domain containing proteins;ENOG4111Q0Y,-","GO:0005829,cellular_component,cytosol","-"]
["FAM111A",2.269041687,1.089035131,1.055759301,3.687329729,0.007431705,0.014640522,"ENSG00000166801","A0A024R4Z3,Family with sequence similarity 111, member A, isoform CRA_a","NP_071357.2,protein FAM111A;NP_942144.1,-;NP_001135993.1,-;NP_001299838.1,-;NP_001135992.1,-;NP_001135991.1,-;NP_001299840.1,-;NP_001299839.1,-","PF13365,Trypsin-like peptidase domain","IPR009003,Peptidase S1, PA clan","ENOG410YPWU,-;ENOG410IH7H,-","GO:0005634,cellular_component,nucleus;GO:0001650,cellular_component,fibrillar center","-"]
["MED16",3.880802943,1.862606036,1.055759301,3.687329729,0.007431705,0.014640522,"ENSG00000175221","K7AEW4,Mediator complex subunit 16","XP_016789990.1,mediator of RNA polymerase II transcription subunit 16","PF11635,Mediator complex subunit 16","IPR017986,WD40-repeat-containing domain;IPR021665,Mediator complex, subunit Med16;IPR011041,Soluble quinoprotein glucose/sorbosone dehydrogenase;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat","ENOG410IDXV,-;ENOG410ZRDM,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003824,molecular_function,catalytic activity;GO:0005634,cellular_component,nucleus;GO:0006351,biological_process,transcription, DNA-templated","K15159,ko04919,Thyroid hormone signaling pathway"]
["CAPZB",22.51397919,10.82766789,1.055363861,5.776447524,{"v":5.77E-5,"d":"5.77E-05"},0.000184524,"ENSG00000077549","B1AK88,Capping protein","NP_001269091.1,F-actin-capping protein subunit beta isoform 4","PF01115,-actin capping protein, beta subunit","IPR037282,F-actin-capping protein subunit alpha/beta;IPR019771,F-actin capping protein, beta subunit, conserved site;IPR001698,F-actin-capping protein subunit beta","-","GO:0030036,biological_process,actin cytoskeleton organization;GO:0048487,molecular_function,beta-tubulin binding;GO:0005903,cellular_component,brush border;GO:0008290,cellular_component,F-actin capping protein complex;GO:0090036,biological_process,regulation of protein kinase C signaling;GO:0051016,biological_process,barbed-end actin filament capping;GO:0030032,biological_process,lamellipodium assembly;GO:0048747,biological_process,muscle fiber development;GO:0014704,cellular_component,intercalated disc;GO:0030027,cellular_component,lamellipodium;GO:0005737,cellular_component,cytoplasm;GO:0030030,biological_process,cell projection organization;GO:0003779,molecular_function,actin binding;GO:0016020,cellular_component,membrane;GO:0001669,cellular_component,acrosomal vesicle;GO:0051015,molecular_function,actin filament binding;GO:0031175,biological_process,neuron projection development;GO:0030018,cellular_component,Z disc;GO:0030863,cellular_component,cortical cytoskeleton;GO:0031115,biological_process,negative regulation of microtubule polymerization","-"]
["GNA15",11.99569046,5.768281084,1.05459536,4.585370202,0.000850693,0.002087239,"ENSG00000060558","A8K5L4,cDNA FLJ76843, highly similar to Homo sapiens guanine nucleotide binding protein","-","PF00503,-protein alpha subunit","IPR011025,G protein alpha subunit, helical insertion;IPR000654,G-protein alpha subunit, group Q;IPR001019,Guanine nucleotide binding protein (G-protein), alpha subunit;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410XNVQ,-;KOG0085,G protein subunit Galphaq/Galphay, small G protein superfamily","GO:0001664,molecular_function,G-protein coupled receptor binding;GO:0005525,molecular_function,GTP binding;GO:0004871,molecular_function,signal transducer activity;GO:0019001,molecular_function,guanyl nucleotide binding;GO:0031683,molecular_function,G-protein beta/gamma-subunit complex binding;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0007165,biological_process,signal transduction","-"]
["SNX8",5.429540824,2.610864104,1.05459536,4.585370202,0.000850693,0.002087239,"ENSG00000106266","B2RDT8,cDNA, FLJ96764, highly similar to Homo sapiens sorting nexin 8","-","PF00787,PX domain","IPR001683,Phox homologous domain;IPR035704,SNX8/Mvp1, PX domain;IPR027267,AH/BAR domain superfamily;IPR036871,PX domain superfamily;IPR028662,Sorting nexin-8/Mvp1","KOG2273,Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins;COG5391,Phox homology (PX) domain protein","GO:0005829,cellular_component,cytosol;GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0035091,molecular_function,phosphatidylinositol binding","-"]
["MACF1",4.027269412,1.938522075,1.054536672,7.015916457,{"v":5.17e-06,"d":"5.17E-06"},{"v":2.1e-05,"d":"2.10E-05"},"ENSG00000127603","H3BQK9,Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5","-","PF02187,rowth-Arrest-Specific Protein 2 Domain;PF13499,-hand domain pair;PF00435,Spectrin repeat;PF00307,Calponin homology (CH) domain;PF00681,Plectin repeat","IPR035915,Plakin repeat superfamily;IPR018247,EF-Hand 1, calcium-binding site;IPR002017,Spectrin repeat;IPR018159,Spectrin/alpha-actinin;IPR036872,CH domain superfamily;IPR001715,Calponin homology domain;IPR002048,EF-hand domain;IPR003108,GAR domain;IPR001101,Plectin repeat;IPR011992,EF-hand domain pair;IPR001589,Actinin-type actin-binding domain, conserved site;IPR036534,GAR domain superfamily","COG5069,Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily);KOG0516,Dystonin, GAS (Growth-arrest-specific protein), and related proteins","GO:0005856,cellular_component,cytoskeleton;GO:0008017,molecular_function,microtubule binding;GO:0003779,molecular_function,actin binding;GO:0005509,molecular_function,calcium ion binding","-"]
["FAM175A",5.954060477,2.865001191,1.05418317,5.133786633,0.00024256,6.75232E-4,"ENSG00000163322","H2RA73,Family with sequence similarity 175, member A","XP_001135565.1,BRCA1-A complex subunit Abraxas","-","IPR037518,MPN domain;IPR023239,FAM175 family, BRCA1-A complex, Abraxas 1 subunit;IPR023238,FAM175 family","ENOG4110D5E,-;ENOG410IG59,-","GO:0072425,biological_process,signal transduction involved in G2 DNA damage checkpoint;GO:0045739,biological_process,positive regulation of DNA repair;GO:0070531,cellular_component,BRCA1-A complex;GO:0031593,molecular_function,polyubiquitin modification-dependent protein binding;GO:0006302,biological_process,double-strand break repair;GO:0010212,biological_process,response to ionizing radiation;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus","-"]
["MAPKBP1",1.054665123,0.506190511,1.054130551,3.139266828,0.020792822,0.036438951,"ENSG00000137802","K7DJS6,Mitogen-activated protein kinase binding protein 1","-","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","-","GO:0016301,molecular_function,kinase activity;GO:0016310,biological_process,phosphorylation","-"]
["CTC-436P18.1",13.72257121,6.586199901,1.054130551,3.139266828,0.020792822,0.036438951,"ENSG00000251279","A0A0D9RU21,Uncharacterized protein","-","-","-","-","-","-"]
["OSER1",21.0829101,10.14378656,1.053996225,4.78320857,6.34612E-4,0.001601759,"ENSG00000132823","H2QKE0,Chromosome 20 open reading frame 111","XP_009435476.1,-;XP_016792650.1,-","PF05604,Protein of unknown function (DUF776)","IPR008494,Protein of unknown function DUF776","ENOG410XZQW,-;ENOG410IHT9,-","-","-"]
["ATXN7L3B",10.64885712,5.127820879,1.053620975,5.926437099,{"v":4.11e-05,"d":"4.11E-05"},1.36114E-4,"ENSG00000253719","G5AXD9,Ataxin-7-like protein 3","XP_004845082.1,-","-","-","-","GO:0005737,cellular_component,cytoplasm;GO:0010468,biological_process,regulation of gene expression","-"]
["C1orf43",52.14558574,25.12678626,1.052922532,6.65256337,{"v":9.41e-06,"d":"9.41E-06"},{"v":3.6e-05,"d":"3.60E-05"},"ENSG00000143612","I6L538,Chromosome 1 open reading frame 43","XP_009241861.1,-","PF07406,NICE-3 protein","IPR010876,NICE-3 predicted","ENOG410XP22,-;ENOG410IJYI,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RHOG",8.794820196,4.229101704,1.052893646,3.627463865,0.010103812,0.019245475,"ENSG00000177105","G3I3B5,Rho-related GTP-binding protein RhoG","XP_003509755.1,-;XP_007616920.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR003578,Small GTPase superfamily, Rho type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0030036,biological_process,actin cytoskeleton organization;GO:1903078,biological_process,positive regulation of protein localization to plasma membrane;GO:0060326,biological_process,cell chemotaxis;GO:0005525,molecular_function,GTP binding;GO:0090630,biological_process,activation of GTPase activity;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:1900027,biological_process,regulation of ruffle assembly;GO:0016601,biological_process,Rac protein signal transduction;GO:0007266,biological_process,Rho protein signal transduction;GO:0005622,cellular_component,intracellular;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding","K07863,ko05100,Bacterial invasion of epithelial cells;K07863,ko05131,Shigellosis;K07863,ko05132,Salmonella infection"]
["USP1",32.6974209,15.75674554,1.05282438,6.702205503,{"v":8.44e-06,"d":"8.44E-06"},{"v":3.26E-5,"d":"3.26E-05"},"ENSG00000162607","B2R636,cDNA, FLJ92762, highly similar to Homo sapiens ubiquitin specific protease 1","-","PF00443,Ubiquitin carboxyl-terminal hydrolase","IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase;IPR033815,Ubiquitin specific peptidase 1","ENOG410XQ81,-;KOG1864,Ubiquitin-specific protease","GO:0006508,biological_process,proteolysis;GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0006282,biological_process,regulation of DNA repair;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0004197,molecular_function,cysteine-type endopeptidase activity;GO:0016579,biological_process,protein deubiquitination;GO:0008233,molecular_function,peptidase activity","-"]
["PLCB1",2.032021689,0.978549227,1.052690763,4.755634999,0.000600879,1.525949E-3,"ENSG00000182621","K7BA21,Phosphoinositide phospholipase C","XP_009435050.1,-","PF06631,Protein of unknown function (DUF1154);PF09279,Phosphoinositide-specific phospholipase C, efhand-like;PF08703,PLC-beta C terminal;PF00387,Phosphatidylinositol-specific phospholipase C, Y domain;PF00388,Phosphatidylinositol-specific phospholipase C, X domain","IPR000909,Phosphatidylinositol-specific phospholipase C, X domain;IPR001192,Phosphoinositide phospholipase C family;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily;IPR037862,PLC-beta, PH domain;IPR028400,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1;IPR016280,Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta;IPR000008,C2 domain;IPR035892,C2 domain superfamily;IPR009535,Phospholipase C-beta, conserved site;IPR011992,EF-hand domain pair;IPR001711,Phospholipase C, phosphatidylinositol-specific, Y domain;IPR015359,Phosphoinositide-specific phospholipase C, EF-hand-like domain;IPR014815,Phospholipase C-beta, C-terminal domain","KOG0169,Phosphoinositide-specific phospholipase C;ENOG410XPSW,-","GO:0048009,biological_process,insulin-like growth factor receptor signaling pathway;GO:0006629,biological_process,lipid metabolic process;GO:0045663,biological_process,positive regulation of myoblast differentiation;GO:0007213,biological_process,G-protein coupled acetylcholine receptor signaling pathway;GO:0070498,biological_process,interleukin-1-mediated signaling pathway;GO:0005509,molecular_function,calcium ion binding;GO:0043547,biological_process,positive regulation of GTPase activity;GO:2000438,biological_process,negative regulation of monocyte extravasation;GO:0016607,cellular_component,nuclear speck;GO:0005096,molecular_function,GTPase activator activity;GO:0005634,cellular_component,nucleus;GO:0016787,molecular_function,hydrolase activity;GO:0021987,biological_process,cerebral cortex development;GO:0035556,biological_process,intracellular signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0005516,molecular_function,calmodulin binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0008277,biological_process,regulation of G-protein coupled receptor protein signaling pathway;GO:0000086,biological_process,G2/M transition of mitotic cell cycle;GO:2000560,biological_process,positive regulation of CD24 biosynthetic process;GO:0000790,cellular_component,nuclear chromatin;GO:0046330,biological_process,positive regulation of JNK cascade;GO:0080154,biological_process,regulation of fertilization;GO:0007215,biological_process,glutamate receptor signaling pathway;GO:0005546,molecular_function,phosphatidylinositol-4,5-bisphosphate binding;GO:0019899,molecular_function,enzyme binding;GO:0060466,biological_process,activation of meiosis involved in egg activation;GO:0004435,molecular_function,phosphatidylinositol phospholipase C activity;GO:0004871,molecular_function,signal transducer activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0040019,biological_process,positive regulation of embryonic development;GO:0035722,biological_process,interleukin-12-mediated signaling pathway;GO:0007420,biological_process,brain development;GO:1900087,biological_process,positive regulation of G1/S transition of mitotic cell cycle;GO:2000344,biological_process,positive regulation of acrosome reaction;GO:0035723,biological_process,interleukin-15-mediated signaling pathway;GO:0016042,biological_process,lipid catabolic process;GO:0007165,biological_process,signal transduction;GO:0048639,biological_process,positive regulation of developmental growth;GO:0043209,cellular_component,myelin sheath;GO:0005521,molecular_function,lamin binding;GO:0007613,biological_process,memory;GO:0008081,molecular_function,phosphoric diester hydrolase activity;GO:0032735,biological_process,positive regulation of interleukin-12 production;GO:0051726,biological_process,regulation of cell cycle;GO:0045444,biological_process,fat cell differentiation","K05858,ko04972,Pancreatic secretion;K05858,ko04916,Melanogenesis;K05858,ko04924,Renin secretion;K05858,ko05146,Amoebiasis;K05858,ko04720,Long-term potentiation;K05858,ko04730,Long-term depression;K05858,ko04713,Circadian entrainment;K05858,ko04921,Oxytocin signaling pathway;K05858,ko04933,AGE-RAGE signaling pathway in diabetic complications;K05858,ko04745,Phototransduction - fly;K05858,ko04911,Insulin secretion;K05858,ko04750,Inflammatory mediator regulation of TRP channels;K05858,ko04919,Thyroid hormone signaling pathway;K05858,ko04070,Phosphatidylinositol signaling system;K05858,ko05143,African trypanosomiasis;K05858,ko04071,Sphingolipid signaling pathway;K05858,ko04970,Salivary secretion;K05858,ko04912,GnRH signaling pathway;K05858,ko04611,Platelet activation;K05858,ko04072,Phospholipase D signaling pathway;K05858,ko04726,Serotonergic synapse;K05858,ko04725,Cholinergic synapse;K05858,ko04022,cGMP-PKG signaling pathway;K05858,ko04540,Gap junction;K05858,ko00562,Inositol phosphate metabolism;K05858,ko04310,Wnt signaling pathway;K05858,ko04728,Dopaminergic synapse;K05858,ko04270,Vascular smooth muscle contraction;K05858,ko04961,Endocrine and other factor-regulated calcium reabsorption;K05858,ko04261,Adrenergic signaling in cardiomyocytes;K05858,ko04723,Retrograde endocannabinoid signaling;K05858,ko04925,Aldosterone synthesis and secretion;K05858,ko04062,Chemokine signaling pathway;K05858,ko05200,Pathways in cancer;K05858,ko04015,Rap1 signaling pathway;K05858,ko04020,Calcium signaling pathway;K05858,ko05010,Alzheimer's disease;K05858,ko05142,Chagas disease (American trypanosomiasis);K05858,ko04971,Gastric acid secretion;K05858,ko04918,Thyroid hormone synthesis;K05858,ko04915,Estrogen signaling pathway;K05858,ko04922,Glucagon signaling pathway;K05858,ko04724,Glutamatergic synapse;K05858,ko05016,Huntington's disease"]
["AC005154.6",0.889247659,0.428038465,1.052231513,3.990784611,0.004107514,0.008618283,"ENSG00000196295","H2PMH4,Uncharacterized protein","-","-","-","-","-","-"]
["CTC-250I14.6",47.44182607,22.86024035,1.052130591,5.090329328,0.000296542,0.0008079,"ENSG00000267598","F7IPF6,Immediate early response 2","XP_008985633.1,immediate early response gene 2 protein","PF05760,Immediate early response protein (IER)","IPR008653,Immediate early response","ENOG410IXGG,-;ENOG410Z3CN,-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0048870,biological_process,cell motility;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["PIR",19.75683534,9.522066676,1.051930909,5.232396914,0.000198454,0.000563863,"ENSG00000087842","A0A024RBX6,Pirin","NP_001018119.1,-;NP_003653.1,pirin","PF02678,Pirin;PF05726,Pirin C-terminal cupin domain","IPR003829,Pirin, N-terminal domain;IPR014710,RmlC-like jelly roll fold;IPR011051,RmlC-like cupin domain superfamily;IPR012093,Pirin;IPR008778,Pirin, C-terminal domain","ENOG410IF52,-;COG1741,Pirin-related protein","GO:0005829,cellular_component,cytosol;GO:0055114,biological_process,oxidation-reduction process;GO:0008127,molecular_function,quercetin 2,3-dioxygenase activity;GO:0030099,biological_process,myeloid cell differentiation","-"]
["TES",41.11167469,19.82823184,1.051689272,7.036306142,{"v":5.32e-06,"d":"5.32E-06"},{"v":2.15e-05,"d":"2.15E-05"},"ENSG00000135269","K7CDU7,Testis derived transcript","NP_001121106.1,-","PF06297,PET Domain;PF00412,LIM domain","IPR034960,Testin, LIM domain 3;IPR027683,Testin;IPR033724,PET testin;IPR034958,Testin, LIM domain 1;IPR010442,PET domain;IPR001781,Zinc finger, LIM-type;IPR034959,Testin, LIM domain 2","ENOG410XQU0,-;ENOG410INGJ,-","GO:0042127,biological_process,regulation of cell proliferation;GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding","-"]
["PHIP",6.612042983,3.189600394,1.051112685,6.03963626,{"v":3.42e-05,"d":"3.42E-05"},1.15227E-4,"ENSG00000146247","K7BM47,Pleckstrin homology domain interacting protein","-","PF00439,Bromodomain;PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR036427,Bromodomain-like superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001487,Bromodomain;IPR028738,PH-interacting protein;IPR018359,Bromodomain, conserved site;IPR001680,WD40 repeat","ENOG410YCD8,-;KOG0644,Uncharacterized conserved protein, contains WD40 repeat and BROMO domains","GO:0008286,biological_process,insulin receptor signaling pathway;GO:0005158,molecular_function,insulin receptor binding","-"]
["PGRMC1",32.91526766,15.87946868,1.050751574,5.574279247,{"v":9.15e-05,"d":"9.15E-05"},0.000278369,"ENSG00000101856","K6ZK25,Progesterone receptor membrane component 1","XP_016799348.1,-","PF00173,Cytochrome b5-like Heme/Steroid binding domain","IPR001199,Cytochrome b5-like heme/steroid binding domain;IPR036400,Cytochrome b5-like heme/steroid binding domain superfamily","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TNFRSF10B",6.583327021,3.176264493,1.049919598,4.698847825,0.000769985,1.905608E-3,"ENSG00000120889","Q6FH58,TNFRSF10B protein","-","PF00531,eath domain;PF00020,TNFR/NGFR cysteine-rich region","IPR034024,Tumor necrosis factor receptor 10, N-terminal;IPR020465,Tumour necrosis factor receptor 10;IPR000488,Death domain;IPR011029,Death-like domain superfamily;IPR001368,TNFR/NGFR cysteine-rich region;IPR034029,Tumour necrosis factor receptor 10A/B, death domain","ENOG410IZX0,-;ENOG4111ZZM,-","GO:0045569,molecular_function,TRAIL binding;GO:0007165,biological_process,signal transduction;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ITPR2",1.918305487,0.925167374,1.049871421,4.241105044,0.002051137,0.004621808,"ENSG00000123104","K7B3H5,Inositol 1,4,5-trisphosphate receptor, type 2","XP_016779253.1,inositol 1,4,5-trisphosphate receptor type 2 isoform X2","PF02815,MIR domain;PF08709,Inositol 1,4,5-trisphosphate/ryanodine receptor;PF00520,Ion transport protein;PF08454,RyR and IP3R Homology associated;PF01365,RIH domain","IPR015925,Ryanodine receptor-related;IPR013662,RyR/IP3R Homology associated domain;IPR035910,RyR/IP3 receptor binding core, RIH domain superfamily;IPR036300,Mir domain superfamily;IPR000493,Inositol 1,4,5-trisphosphate receptor;IPR005821,Ion transport domain;IPR016093,MIR motif;IPR000699,RIH domain;IPR016024,Armadillo-type fold;IPR014821,Inositol 1,4,5-trisphosphate/ryanodine receptor","ENOG410XR97,-;KOG3533,Inositol 1,4,5-trisphosphate receptor","GO:0005216,molecular_function,ion channel activity;GO:0070679,molecular_function,inositol 1,4,5 trisphosphate binding;GO:0005262,molecular_function,calcium channel activity;GO:0055085,biological_process,transmembrane transport;GO:0005220,molecular_function,inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0016020,cellular_component,membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0006811,biological_process,ion transport;GO:0048016,biological_process,inositol phosphate-mediated signaling;GO:0006816,biological_process,calcium ion transport;GO:0016021,cellular_component,integral component of membrane;GO:0070588,biological_process,calcium ion transmembrane transport","-"]
["MPP2",3.223616627,1.554177283,1.049829951,3.942548441,0.004447256,0.009232417,"ENSG00000108852","A0A0C4DH75,MAGUK p55 subfamily member 2","NP_001265299.1,MAGUK p55 subfamily member 2 isoform 1","PF07653,Variant SH3 domain;PF02828,L27 domain;PF00625,uanylate kinase;PF00595,PDZ domain (Also known as DHR or GLGF)","IPR014775,L27 domain, C-terminal;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036892,L27 domain superfamily;IPR035602,MPP2, SH3 domain;IPR036028,SH3-like domain superfamily;IPR020590,Guanylate kinase, conserved site;IPR008144,Guanylate kinase-like domain;IPR008145,Guanylate kinase/L-type calcium channel beta subunit;IPR001452,SH3 domain;IPR004172,L27 domain","COG0194,Guanylate kinase;KOG0609,Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase","GO:0060291,biological_process,long-term synaptic potentiation;GO:0043197,cellular_component,dendritic spine;GO:0030165,molecular_function,PDZ domain binding;GO:0043198,cellular_component,dendritic shaft;GO:0044325,molecular_function,ion channel binding;GO:0051260,biological_process,protein homooligomerization;GO:0014069,cellular_component,postsynaptic density;GO:0032590,cellular_component,dendrite membrane;GO:0060079,biological_process,excitatory postsynaptic potential","-"]
["SLC25A38",9.162804304,4.417591775,1.049829951,3.942548441,0.004447256,0.009232417,"ENSG00000144659","G3RCH1,Solute carrier family 25 member 38","XP_004033945.1,-","PF00153,Mitochondrial carrier protein","IPR018108,Mitochondrial substrate/solute carrier;IPR023395,Mitochondrial carrier domain superfamily;IPR030847,Mitochondrial glycine transporter Hem25/SLC25A38","-","GO:1904983,biological_process,glycine import into mitochondrion;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0030218,biological_process,erythrocyte differentiation;GO:0016021,cellular_component,integral component of membrane;GO:0015187,molecular_function,glycine transmembrane transporter activity","-"]
["RP11-282O18.3",8.51935601,4.105122888,1.049762213,3.564979839,0.01381579,0.025550161,"-","-","-","-","-","-","-","-"]
["ABHD1",3.231099169,1.556932136,1.049762213,3.564979839,0.01381579,0.025550161,"ENSG00000143994","A0A140VJD1,Abhydrolase domain containing 1, isoform CRA_b","NP_115993.3,protein ABHD1","PF12697,Alpha/beta hydrolase family;PF00561,alpha/beta hydrolase fold;PF12146,Serine aminopeptidase, S33","IPR012020,AB hydrolase 4 family;IPR000952,AB hydrolase 4, conserved site;IPR000073,Alpha/beta hydrolase fold-1;IPR029058,Alpha/Beta hydrolase fold","-","GO:0016787,molecular_function,hydrolase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["GATB",1.272432521,0.613132244,1.049762213,3.564979839,0.01381579,0.025550161,"ENSG00000059691","H2QQA1,Glutamyl-tRNA","-","PF02637,atB domain;PF02934,atB/GatE catalytic domain","IPR006075,Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic;IPR018027,Asn/Gln amidotransferase;IPR004413,Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit;IPR017958,Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site;IPR017959,Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E;IPR003789,Aspartyl/glutamyl-tRNA amidotransferase subunit B-like;IPR014746,Glutamine synthetase/guanido kinase, catalytic domain;IPR023168,Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal","KOG2438,Glutamyl-tRNA amidotransferase subunit B;COG0064,Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)","GO:0003824,molecular_function,catalytic activity;GO:0050567,molecular_function,glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity;GO:0005524,molecular_function,ATP binding;GO:0030956,cellular_component,glutamyl-tRNA(Gln) amidotransferase complex;GO:0032543,biological_process,mitochondrial translation;GO:0016874,molecular_function,ligase activity;GO:0016884,molecular_function,carbon-nitrogen ligase activity, with glutamine as amido-N-donor;GO:0070681,biological_process,glutaminyl-tRNAGln biosynthesis via transamidation;GO:0000166,molecular_function,nucleotide binding;GO:0006412,biological_process,translation;GO:0005739,cellular_component,mitochondrion","-"]
["RPP30",2.194452235,1.056297373,1.049631683,3.050497175,0.030066952,0.050497543,"ENSG00000148688","F7EC73,Ribonuclease P/MRP subunit p30","-","PF01876,RNase P subunit p30","IPR002738,RNase P subunit p30;IPR016195,Polymerase/histidinol phosphatase-like","-","GO:0004526,molecular_function,ribonuclease P activity;GO:0003824,molecular_function,catalytic activity;GO:0000172,cellular_component,ribonuclease MRP complex;GO:0004540,molecular_function,ribonuclease activity;GO:0001682,biological_process,tRNA 5'-leader removal;GO:0030681,cellular_component,multimeric ribonuclease P complex;GO:0008033,biological_process,tRNA processing;GO:0090501,biological_process,RNA phosphodiester bond hydrolysis;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic","-"]
["AC000041.8",58.34734998,28.08543815,1.049631683,3.050497175,0.030066952,0.050497543,"ENSG00000242156","M7ALL5,AP-1 complex subunit beta-1","-","PF09066,Beta2-adaptin appendage, C-terminal sub-domain;PF02883,Adaptin C-terminal domain;PF01602,Adaptin N terminal region","IPR013041,Clathrin adaptor, appendage, Ig-like subdomain superfamily;IPR008152,Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain;IPR012295,TBP domain superfamily;IPR000225,Armadillo;IPR026739,AP complex subunit beta;IPR015151,Beta-adaptin appendage, C-terminal subdomain;IPR016024,Armadillo-type fold;IPR009028,Coatomer/calthrin adaptor appendage, C-terminal subdomain;IPR011989,Armadillo-like helical;IPR002553,Clathrin/coatomer adaptor, adaptin-like, N-terminal;IPR013037,Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain","-","GO:0005737,cellular_component,cytoplasm;GO:0015031,biological_process,protein transport;GO:0030131,cellular_component,clathrin adaptor complex;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0030117,cellular_component,membrane coat;GO:0006886,biological_process,intracellular protein transport","-"]
["MKI67",63.80107441,30.82958158,1.049200418,9.245144819,{"v":7.13e-07,"d":"7.13E-07"},{"v":3.47e-06,"d":"3.47E-06"},"ENSG00000148773","H2Q2S1,Uncharacterized protein","XP_508147.3,antigen KI-67 isoform X1","PF08065,K167R (NUC007) repeat;PF15276,Protein phosphatase 1 binding;PF00498,HA domain","IPR008984,SMAD/FHA domain superfamily;IPR012568,KI67R;IPR000253,Forkhead-associated (FHA) domain;IPR029334,Protein phosphatase 1 binding domain","ENOG410JR7C,-;ENOG410ZXYW,-","GO:0005730,cellular_component,nucleolus;GO:0051983,biological_process,regulation of chromosome segregation;GO:0008022,molecular_function,protein C-terminus binding;GO:0007088,biological_process,regulation of mitotic nuclear division;GO:0000793,cellular_component,condensed chromosome;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus","-"]
["CTB-89H12.4",9.816265848,4.742696924,1.048840392,5.993248616,{"v":3.68E-5,"d":"3.68E-05"},1.23297E-4,"ENSG00000230551","Q8WXF2,HLCDGP1","-","-","-","-","-","-"]
["RP11-973D8.4",131.9690011,63.79288311,1.04802045,5.810817759,{"v":5.45e-05,"d":"5.45E-05"},0.00017524,"ENSG00000258554","F6ZHC1,Cyclin dependent kinase 2","-","PF00069,Protein kinase domain","IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain","ENOG410XPP3,-;KOG0594,Protein kinase PCTAIRE and related kinases","GO:0030332,molecular_function,cyclin binding;GO:0010389,biological_process,regulation of G2/M transition of mitotic cell cycle;GO:0004693,molecular_function,cyclin-dependent protein serine/threonine kinase activity;GO:0005737,cellular_component,cytoplasm;GO:0006468,biological_process,protein phosphorylation;GO:0007275,biological_process,multicellular organism development;GO:0000082,biological_process,G1/S transition of mitotic cell cycle;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0004672,molecular_function,protein kinase activity;GO:0005524,molecular_function,ATP binding;GO:0010468,biological_process,regulation of gene expression;GO:0000307,cellular_component,cyclin-dependent protein kinase holoenzyme complex;GO:0010033,biological_process,response to organic substance;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction;GO:0004674,molecular_function,protein serine/threonine kinase activity","-"]
["TLDC1",2.910407468,1.405591442,1.047809966,4.200706249,0.002632089,0.005780601,"ENSG00000140950","D3DUL8,KIAA1609 protein, isoform CRA_a","-","PF07534,TLD","IPR006571,TLDc domain","KOG2557,Uncharacterized conserved protein, contains TLDc domain;ENOG410XR8F,-","GO:0005765,cellular_component,lysosomal membrane","-"]
["CDCA7L",31.59140863,15.28130942,1.047352457,6.589826825,{"v":1.14e-05,"d":"1.14E-05"},{"v":4.29e-05,"d":"4.29E-05"},"ENSG00000164649","A0A024RA51,Cell division cycle associated 7-like, isoform CRA_d","NP_061189.2,cell division cycle-associated 7-like protein isoform 1","PF10497,Zinc-finger domain of monoamine-oxidase A repressor R1","IPR018866,Zinc-finger domain of monoamine-oxidase A repressor R1;IPR033578,Cell division cycle-associated 7-like protein","ENOG410XQV7,-;ENOG410IYXY,-","GO:0005730,cellular_component,nucleolus;GO:0001650,cellular_component,fibrillar center;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0051301,biological_process,cell division;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["NCLN",7.792105366,3.76714859,1.04691199,4.639723219,0.000994692,0.002403087,"ENSG00000125912","H9EQB1,Nicalin","XP_014977933.1,-","PF04389,Peptidase family M28","IPR016574,Nicalin;IPR007484,Peptidase M28","KOG2526,Predicted aminopeptidases - M20/M25/M40 family;ENOG410XQZK,-","GO:0009966,biological_process,regulation of signal transduction;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["SLC25A28",8.118295565,3.920759172,1.046326221,3.49963685,0.010890325,0.020514808,"ENSG00000155287","F7HAL7,Mitoferrin-2","NP_001252686.1,-","PF00153,Mitochondrial carrier protein","IPR018108,Mitochondrial substrate/solute carrier;IPR023395,Mitochondrial carrier domain superfamily","ENOG410XNT2,-;KOG0760,Mitochondrial carrier protein MRS3/4","GO:0048250,biological_process,iron import into the mitochondrion;GO:0055072,biological_process,iron ion homeostasis;GO:0006839,biological_process,mitochondrial transport;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0005381,molecular_function,iron ion transmembrane transporter activity;GO:0016021,cellular_component,integral component of membrane","-"]
["IKBIP",3.422437837,1.652878296,1.046326221,3.49963685,0.010890325,0.020514808,"ENSG00000166130","G3QZA1,IKBKB interacting protein","-","-","IPR024152,Inhibitor of nuclear factor kappa-B kinase-interacting protein","-","GO:0005783,cellular_component,endoplasmic reticulum","-"]
["KLHDC2",2.082679245,1.005837209,1.046326221,3.49963685,0.010890325,0.020514808,"ENSG00000165516","G3R0X3,Kelch domain containing 2","-","PF13418,alactose oxidase, central domain","IPR015915,Kelch-type beta propeller;IPR011043,Galactose oxidase/kelch, beta-propeller","-","GO:0031965,cellular_component,nuclear membrane;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus","-"]
["ZNF264",1.136898238,0.549068971,1.046326221,3.49963685,0.010890325,0.020514808,"ENSG00000083844","G3QTL0,Zinc finger protein 264","XP_004061581.1,zinc finger protein 264 isoform X1","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["MFAP3",2.973207161,1.435920774,1.046326221,3.49963685,0.010890325,0.020514808,"ENSG00000037749","H2QRU9,Microfibrillar-associated protein 3","XP_016809586.1,-;XP_003310979.1,microfibril-associated glycoprotein 3 isoform X1;XP_016809587.1,-;XP_016809588.1,-;XP_003310981.1,-;XP_009448288.1,-","PF00047,Immunoglobulin domain","IPR013151,Immunoglobulin;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR007110,Immunoglobulin-like domain","ENOG410XPPH,-;ENOG410IE5Z,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ORC5",3.825888485,1.847726194,1.046326221,3.49963685,0.010890325,0.020514808,"ENSG00000164815","H2QV68,Origin recognition complex, subunit 5","XP_519292.3,-","PF13191,AAA ATPase domain;PF14630,Origin recognition complex (ORC) subunit 5 C-terminus","IPR020796,Origin recognition complex, subunit 5;IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410XSY0,-;KOG2543,Origin recognition complex, subunit 5","GO:0005664,cellular_component,nuclear origin of replication recognition complex;GO:0006270,biological_process,DNA replication initiation;GO:0006260,biological_process,DNA replication;GO:0000808,cellular_component,origin recognition complex;GO:0003688,molecular_function,DNA replication origin binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus","-"]
["FBXL3",10.22667951,4.950577326,1.045938913,5.770119636,{"v":6.98e-05,"d":"6.98E-05"},0.000218955,"ENSG00000005812","G3QVS1,F-box and leucine rich repeat protein 3","XP_018895155.1,-","PF12937,-box-like","IPR036047,F-box-like domain superfamily;IPR032675,Leucine-rich repeat domain superfamily;IPR001810,F-box domain","-","-","-"]
["DUS1L",9.816655448,4.751911939,1.045825538,5.476453464,1.21187E-4,0.000359828,"ENSG00000169718","H2R9B8,Dihydrouridine synthase 1-like","-","PF01207,ihydrouridine synthase (Dus)","IPR035587,DUS-like, FMN-binding domain;IPR001269,tRNA-dihydrouridine synthase;IPR018517,tRNA-dihydrouridine synthase, conserved site;IPR013785,Aldolase-type TIM barrel","KOG2335,tRNA-dihydrouridine synthase;COG0042,tRNA-dihydrouridine synthase","GO:0002943,biological_process,tRNA dihydrouridine synthesis;GO:0003824,molecular_function,catalytic activity;GO:0017150,molecular_function,tRNA dihydrouridine synthase activity;GO:0050660,molecular_function,flavin adenine dinucleotide binding;GO:0055114,biological_process,oxidation-reduction process;GO:0008033,biological_process,tRNA processing","-"]
["YIPF5",12.25476567,5.931761908,1.045644565,5.107182912,0.000285915,0.000783188,"ENSG00000145817","H2QRP8,Protein YIPF","XP_518011.2,-","PF04893,Yip1 domain","IPR006977,Yip1 domain","KOG3103,Rab GTPase interacting factor, Golgi membrane protein;COG5080,Rab GTPase interacting factor, Golgi membrane protein","GO:0005794,cellular_component,Golgi apparatus;GO:0005783,cellular_component,endoplasmic reticulum;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0030134,cellular_component,COPII-coated ER to Golgi transport vesicle;GO:0042175,cellular_component,nuclear outer membrane-endoplasmic reticulum membrane network;GO:0060628,biological_process,regulation of ER to Golgi vesicle-mediated transport;GO:0016020,cellular_component,membrane;GO:0070971,cellular_component,endoplasmic reticulum exit site;GO:0016021,cellular_component,integral component of membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["SPTLC1",27.00476228,13.07787397,1.045550778,6.212369188,{"v":2.61e-05,"d":"2.61E-05"},{"v":9.06e-05,"d":"9.06E-05"},"ENSG00000090054","A0A024R277,Serine palmitoyltransferase, long chain base subunit 1, isoform CRA_a","NP_006406.1,serine palmitoyltransferase 1 isoform a","PF00155,Aminotransferase class I and II","IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR015422,Pyridoxal phosphate-dependent transferase domain 1;IPR015424,Pyridoxal phosphate-dependent transferase;IPR004839,Aminotransferase, class I/classII","KOG1358,Serine palmitoyltransferase;COG0156,7-keto-8-aminopelargonate synthetase and related enzymes","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0046513,biological_process,ceramide biosynthetic process;GO:0046512,biological_process,sphingosine biosynthetic process;GO:0046511,biological_process,sphinganine biosynthetic process;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0009058,biological_process,biosynthetic process;GO:0016020,cellular_component,membrane;GO:0006686,biological_process,sphingomyelin biosynthetic process;GO:0016021,cellular_component,integral component of membrane","K00654,ko04071,Sphingolipid signaling pathway;K00654,ko00600,Sphingolipid metabolism"]
["TRAPPC3",9.021735035,4.366368562,1.045309855,4.609222453,1.225678E-3,0.002907124,"ENSG00000054116","A0A087WWM0,Trafficking protein particle complex subunit","NP_001257823.1,trafficking protein particle complex subunit 3 isoform 2","PF04051,Transport protein particle (TRAPP) component","IPR007194,Transport protein particle (TRAPP) component;IPR016721,Bet3 family;IPR024096,NO signalling/Golgi transport ligand-binding domain superfamily","KOG3330,Transport protein particle (TRAPP) complex subunit;ENOG410Z1VV,-","GO:0005794,cellular_component,Golgi apparatus;GO:0048193,biological_process,Golgi vesicle transport;GO:0005783,cellular_component,endoplasmic reticulum;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:0000139,cellular_component,Golgi membrane;GO:0030008,cellular_component,TRAPP complex;GO:0016192,biological_process,vesicle-mediated transport;GO:0005829,cellular_component,cytosol","-"]
["ZC3H18",11.8894823,5.759116981,1.045252536,6.269630726,{"v":2.23E-5,"d":"2.23E-05"},{"v":7.87e-05,"d":"7.87E-05"},"ENSG00000158545","E7ERS3,Zinc finger CCCH domain-containing protein 18","NP_001281269.1,zinc finger CCCH domain-containing protein 18 isoform 1","-","-","ENOG4111IXQ,-;ENOG410IJ7N,-","GO:0016607,cellular_component,nuclear speck","-"]
["SNRPB",159.793212,77.42907701,1.045000178,7.252058963,{"v":4.33E-6,"d":"4.33E-06"},{"v":1.79e-05,"d":"1.79E-05"},"ENSG00000125835","Q9UIS4,Small nuclear ribonucleoprotein-associated protein","-","PF01423,LSM domain","IPR017131,Small ribonucleoprotein associated, SmB/SmN;IPR010920,LSM domain superfamily;IPR001163,LSM domain, eukaryotic/archaea-type","COG1958,Small nuclear ribonucleoprotein (snRNP) homolog;KOG3168,U1 snRNP component","GO:0003723,molecular_function,RNA binding;GO:0005634,cellular_component,nucleus;GO:0030529,,","-"]
["JDP2",15.6148612,7.567527841,1.044483664,6.191978449,{"v":2.51E-5,"d":"2.51E-05"},{"v":8.74e-05,"d":"8.74E-05"},"ENSG00000140044","H2Q8N0,Uncharacterized protein","XP_009426444.1,-;XP_009426443.1,-;XP_016781929.1,-","PF00170,bZIP transcription factor","IPR000837,AP-1 transcription factor;IPR029819,Jun dimerization protein 2;IPR004827,Basic-leucine zipper domain","KOG1414,Transcriptional activator FOSB/c-Fos and related bZIP transcription factors;ENOG4111CH5,-","GO:0003677,molecular_function,DNA binding;GO:0031063,biological_process,regulation of histone deacetylation;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["CCHCR1",5.322543563,2.576983445,1.044481984,4.383815483,0.001769171,0.00405112,"ENSG00000204536","A0A0G2JP87,Coiled-coil alpha-helical rod protein 1","-","PF07111,Alpha helical coiled-coil rod protein (HCR)","IPR009800,Coiled-coil alpha-helical rod protein 1","-","GO:0030154,biological_process,cell differentiation","-"]
["LACTB2",9.468892381,4.581518911,1.044480868,3.840907477,0.00782065,0.015335411,"ENSG00000147592","A0A024R811,Lactamase, beta 2, isoform CRA_a","NP_057111.1,endoribonuclease LACTB2","PF00753,Metallo-beta-lactamase superfamily","IPR036866,Ribonuclease Z/Hydroxyacylglutathione hydrolase-like;IPR001279,Metallo-beta-lactamase;IPR036388,Winged helix-like DNA-binding domain superfamily","KOG0813,Glyoxylase;COG0491,Zn-dependent hydrolases, including glyoxylases","GO:0005739,cellular_component,mitochondrion","-"]
["ATAD3B",1.236449598,0.597147648,1.044477693,2.955822226,0.034093522,0.056009295,"ENSG00000160072","K7CVM9,ATPase family, AAA domain containing 3A","-","PF12037,omain of unknown function (DUF3523);PF00004,ATPase family associated with various cellular activities (AAA)","IPR003959,ATPase, AAA-type, core;IPR003593,AAA+ ATPase domain;IPR021911,ATPase family AAA domain-containing protein 3, domain of unknown function DUF3523;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005524,molecular_function,ATP binding","-"]
["PARPBP",2.001771509,0.966762536,1.044477693,2.955822226,0.034093522,0.056009295,"ENSG00000185480","B4DZ31,PCNA-interacting partner","NP_001306922.1,-;NP_001306917.1,PCNA-interacting partner isoform 1","-","IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410IEAT,-;ENOG4111W85,-","GO:0005654,cellular_component,nucleoplasm","-"]
["NDUFAF5",1.316115534,0.63562259,1.044477693,2.955822226,0.034093522,0.056009295,"ENSG00000101247","H2QJZ4,Chromosome 20 open reading frame 7","XP_514521.2,NADH dehydrogenase","PF13649,Methyltransferase domain;PF13489,Methyltransferase domain;PF08242,Methyltransferase domain;PF13847,Methyltransferase domain;PF08241,Methyltransferase domain;PF03141,Putative S-adenosyl-L-methionine-dependent methyltransferase;PF01209,ubiE/COQ5 methyltransferase family","IPR013216,Methyltransferase type 11;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase","KOG2940,Predicted methyltransferase;COG0500,SAM-dependent methyltransferases","GO:0008168,molecular_function,methyltransferase activity;GO:0032981,biological_process,mitochondrial respiratory chain complex I assembly;GO:0030961,biological_process,peptidyl-arginine hydroxylation;GO:0031314,cellular_component,extrinsic component of mitochondrial inner membrane;GO:0008152,biological_process,metabolic process;GO:0032259,biological_process,methylation;GO:0005739,cellular_component,mitochondrion","-"]
["FUBP1",49.4953109,23.99935223,1.044108309,7.707803044,{"v":2.51e-06,"d":"2.51E-06"},{"v":1.09e-05,"d":"1.09E-05"},"ENSG00000162613","E9PEB5,Far upstream element-binding protein 1","-","PF09005,omain of unknown function (DUF1897);PF00013,KH domain","IPR004087,K Homology domain;IPR004088,K Homology domain, type 1;IPR036612,K Homology domain, type 1 superfamily;IPR015096,Far upstream element-binding protein, C-terminal","KOG1676,K-homology type RNA binding proteins;ENOG410XZYE,-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0003723,molecular_function,RNA binding;GO:0005654,cellular_component,nucleoplasm","-"]
["ITM2C",18.64394094,9.0355297,1.043942152,5.20757362,2.31981E-4,6.47351E-4,"ENSG00000135916","G3QII8,Integral membrane protein 2C","XP_004033378.1,-;XP_018877757.1,-","PF04089,BRICHOS domain","IPR007084,BRICHOS domain","-","GO:0005794,cellular_component,Golgi apparatus;GO:0010977,biological_process,negative regulation of neuron projection development;GO:0001540,molecular_function,amyloid-beta binding;GO:2001238,biological_process,positive regulation of extrinsic apoptotic signaling pathway;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0005764,cellular_component,lysosome;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0005524,molecular_function,ATP binding;GO:0030182,biological_process,neuron differentiation","-"]
["TIMM23",32.64591195,15.8200845,1.043822878,4.92697189,0.000533668,0.001376774,"ENSG00000265354","F7A0I0,Mitochondrial import inner membrane translocase subunit TIM23","NP_001177902.1,-","PF02466,Tim17/Tim22/Tim23/Pmp24 family","IPR005681,Mitochondrial inner membrane translocase complex, subunit Tim23;IPR003397,Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24","KOG3324,Mitochondrial import inner membrane translocase, subunit TIM23;COG5596,Mitochondrial import inner membrane translocase, subunit TIM22","GO:0031305,cellular_component,integral component of mitochondrial inner membrane;GO:0005744,cellular_component,mitochondrial inner membrane presequence translocase complex;GO:0015031,biological_process,protein transport;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0071806,biological_process,protein transmembrane transport;GO:0015450,molecular_function,P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0005758,cellular_component,mitochondrial intermembrane space;GO:0016021,cellular_component,integral component of membrane;GO:0006886,biological_process,intracellular protein transport","K17794,ko04212,Longevity regulating pathway - worm"]
["SNX6",18.10597454,8.78026284,1.043420675,5.807732443,{"v":5.99e-05,"d":"5.99E-05"},0.00019078,"ENSG00000129515","A0A0A0MRI2,Sorting nexin","NP_689419.2,sorting nexin-6 isoform b","PF09325,Vps5 C terminal like;PF00787,PX domain","IPR015404,Sorting nexin Vps5-like, C-terminal;IPR014637,Sorting nexin-5/6/32;IPR036871,PX domain superfamily;IPR027267,AH/BAR domain superfamily;IPR028657,Sorting nexin-6;IPR001683,Phox homologous domain","ENOG410XPZY,-;KOG1660,Sorting nexin SNX6/TFAF2, contains PX domain","GO:0015031,biological_process,protein transport;GO:0005768,cellular_component,endosome;GO:0005764,cellular_component,lysosome;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0034713,molecular_function,type I transforming growth factor beta receptor binding;GO:0006886,biological_process,intracellular protein transport","K17920,ko04144,Endocytosis"]
["E4F1",3.486606319,1.68898683,1.043303189,4.116323482,0.003652463,0.007753474,"ENSG00000167967","K7D3G1,E4F transcription factor 1","XP_016784121.1,transcription factor E4F1 isoform X4","PF00096,Zinc finger, C2H2 type;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0006260,biological_process,DNA replication;GO:0035497,molecular_function,cAMP response element binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0010564,biological_process,regulation of cell cycle process;GO:0009794,biological_process,regulation of mitotic cell cycle, embryonic;GO:0005819,cellular_component,spindle;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["SRBD1",4.424430854,2.143289135,1.043303189,4.116323482,0.003652463,0.007753474,"ENSG00000068784","B3KPM8,cDNA FLJ31974 fis, clone NT2RP7008167, weakly similar to 85.1 kDa PROTEIN IN GREB-FEOA INTERGENIC REGION","-","PF12836,Helix-hairpin-helix motif;PF00575,S1 RNA binding domain;PF16921,Tex protein YqgF-like domain;PF09371,Tex-like protein N-terminal domain","IPR023323,Tex-like domain superfamily;IPR003029,S1 domain;IPR006641,YqgF/RNase H-like domain;IPR010994,RuvA domain 2-like;IPR023319,Tex-like protein, HTH domain superfamily;IPR037027,YqgF/RNase H-like domain superfamily;IPR018974,Tex-like protein, N-terminal;IPR012337,Ribonuclease H-like superfamily;IPR032639,Tex protein, YqgF-like domain;IPR022967,RNA-binding domain, S1;IPR012340,Nucleic acid-binding, OB-fold","COG2183,Transcriptional accessory protein;KOG1857,Transcription accessory protein TEX, contains S1 domain","GO:0003676,molecular_function,nucleic acid binding;GO:0006139,biological_process,nucleobase-containing compound metabolic process","-"]
["MRPL50",6.699055719,3.245166173,1.043303189,4.116323482,0.003652463,0.007753474,"ENSG00000136897","H2PSX0,39S ribosomal protein L50, mitochondrial","-","PF10501,Ribosomal subunit 39S","IPR018305,Ribosomal protein L50, mitochondria","ENOG4111QY3,-;ENOG410J127,-","GO:0005762,cellular_component,mitochondrial large ribosomal subunit;GO:0005739,cellular_component,mitochondrion","-"]
["MARS",16.04917032,7.785969739,1.043083052,6.402543753,{"v":1.74e-05,"d":"1.74E-05"},{"v":6.3E-5,"d":"6.30E-05"},"ENSG00000166986","A8K492,cDNA FLJ76789, highly similar to Homo sapiens methionine-tRNA synthetase","-","PF00043,lutathione S-transferase, C-terminal domain;PF09334,tRNA synthetases class I (M);PF00458,WHEP-TRS domain","IPR029038,Methionyl-tRNA synthetase, Zn-domain;IPR036282,Glutathione S-transferase, C-terminal domain superfamily;IPR010987,Glutathione S-transferase, C-terminal-like;IPR023458,Methionine-tRNA ligase, type 1;IPR009080,Aminoacyl-tRNA synthetase, class Ia, anticodon-binding;IPR014758,Methionyl-tRNA synthetase;IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR001412,Aminoacyl-tRNA synthetase, class I, conserved site;IPR015413,Methionyl/Leucyl tRNA synthetase;IPR004046,Glutathione S-transferase, C-terminal;IPR033911,Methioninyl-tRNA synthetase core domain;IPR009068,S15/NS1, RNA-binding;IPR000738,WHEP-TRS domain","KOG0867,Glutathione S-transferase;COG0143,Methionyl-tRNA synthetase;KOG1247,Methionyl-tRNA synthetase","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0006412,biological_process,translation;GO:0004825,molecular_function,methionine-tRNA ligase activity;GO:0016874,molecular_function,ligase activity;GO:0006431,biological_process,methionyl-tRNA aminoacylation;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["CDC25C",8.650500862,4.193920039,1.042486336,4.347288649,0.001884664,0.004289944,"ENSG00000158402","B4DX61,cDNA FLJ56262, highly similar to M-phase inducer phosphatase 3","NP_001305027.1,M-phase inducer phosphatase 3 isoform e","PF00581,Rhodanese-like domain;PF06617,M-phase inducer phosphatase","IPR001763,Rhodanese-like domain;IPR036873,Rhodanese-like domain superfamily;IPR000751,M-phase inducer phosphatase","KOG3772,M-phase inducer phosphatase;COG5105,Mitotic inducer, protein phosphatase","GO:0006470,biological_process,protein dephosphorylation;GO:0005622,cellular_component,intracellular;GO:1902751,biological_process,positive regulation of cell cycle G2/M phase transition;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation","-"]
["RER1",9.137896998,4.433330745,1.042458894,5.301420698,0.000191185,5.46004E-4,"ENSG00000157916","A0A0D9S8V7,Protein RER1","XP_007979114.1,-","PF03248,Rer1 family","IPR004932,Retrieval of early ER protein Rer1","-","GO:0033130,molecular_function,acetylcholine receptor binding;GO:0009986,cellular_component,cell surface;GO:1903078,biological_process,positive regulation of protein localization to plasma membrane;GO:0071340,biological_process,skeletal muscle acetylcholine-gated channel clustering;GO:0007528,biological_process,neuromuscular junction development;GO:0005794,cellular_component,Golgi apparatus;GO:0005793,cellular_component,endoplasmic reticulum-Golgi intermediate compartment;GO:0005886,cellular_component,plasma membrane;GO:0030173,cellular_component,integral component of Golgi membrane;GO:0006890,biological_process,retrograde vesicle-mediated transport, Golgi to ER;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ACAP2",9.998097508,4.853619574,1.042120177,6.384688605,{"v":1.9e-05,"d":"1.90E-05"},{"v":6.8e-05,"d":"6.80E-05"},"ENSG00000114331","H2QP05,ArfGAP with coiled-coil, ankyrin repeat and PH domains 2","XP_516962.3,-","PF12796,Ankyrin repeats (3 copies);PF01412,Putative GTPase activating protein for Arf;PF16746,BAR domain of APPL family;PF00169,PH domain","IPR037278,ARFGAP/RecO-like zinc finger;IPR038508,ArfGAP domain superfamily;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR020683,Ankyrin repeat-containing domain;IPR027267,AH/BAR domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily;IPR001164,Arf GTPase activating protein;IPR002110,Ankyrin repeat","COG5347,GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport;KOG0521,Putative GTPase activating proteins (GAPs)","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0080025,molecular_function,phosphatidylinositol-3,5-bisphosphate binding;GO:0005096,molecular_function,GTPase activator activity;GO:0046872,molecular_function,metal ion binding;GO:0017137,molecular_function,Rab GTPase binding","-"]
["CTDSPL2",6.215976902,3.017283664,1.041855311,5.505995699,0.000115076,0.000343392,"ENSG00000137770","A0A024R5Q8,CTD","NP_057480.2,CTD small phosphatase-like protein 2;XP_005254498.1,-;XP_006720628.1,-","PF03031,NLI interacting factor-like phosphatase","IPR004274,FCP1 homology domain;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR011948,Dullard phosphatase domain, eukaryotic","KOG1605,TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation);COG5190,TFIIF-interacting CTD phosphatases, including NLI-interacting factor","GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0030514,biological_process,negative regulation of BMP signaling pathway;GO:0006470,biological_process,protein dephosphorylation;GO:0005654,cellular_component,nucleoplasm;GO:0046827,biological_process,positive regulation of protein export from nucleus;GO:0005634,cellular_component,nucleus;GO:0016791,molecular_function,phosphatase activity","-"]
["STAT2",2.876420159,1.394540771,1.041490335,3.787244502,0.006216513,0.012472552,"ENSG00000170581","R9QE65,Signal transducer and activator of transcription","NP_005410.1,signal transducer and activator of transcription 2 isoform 1","PF12188,Signal transducer and activator of transcription 2 C terminal;PF02865,STAT protein, protein interaction domain;PF01017,STAT protein, all-alpha domain;PF00017,SH2 domain;PF02864,STAT protein, DNA binding domain","IPR036860,SH2 domain superfamily;IPR015988,STAT transcription factor, coiled coil;IPR036535,STAT transcription factor, N-terminal domain superfamily;IPR008967,p53-like transcription factor, DNA-binding;IPR013801,STAT transcription factor, DNA-binding;IPR000980,SH2 domain;IPR012345,STAT transcription factor, DNA-binding, N-terminal;IPR013800,STAT transcription factor, all-alpha domain;IPR035854,STAT2, SH2 domain;IPR022756,Signal transducer and activation of transcription 2, C-terminal;IPR013799,STAT transcription factor, protein interaction;IPR001217,Transcription factor STAT","KOG3667,STAT protein;ENOG410XPN8,-","GO:0003677,molecular_function,DNA binding;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0004871,molecular_function,signal transducer activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005886,cellular_component,plasma membrane;GO:0006351,biological_process,transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0007165,biological_process,signal transduction","K11221,ko04062,Chemokine signaling pathway;K11221,ko04380,Osteoclast differentiation;K11221,ko05168,Herpes simplex infection;K11221,ko05161,Hepatitis B;K11221,ko05160,Hepatitis C;K11221,ko04630,Jak-STAT signaling pathway;K11221,ko05164,Influenza A;K11221,ko05162,Measles"]
["ZBTB46",2.888239768,1.400271133,1.041490335,3.787244502,0.006216513,0.012472552,"ENSG00000130584","Q6ZMU8,cDNA FLJ16656 fis, clone TESTI4038779, weakly similar to Rattus norvegicus zinc finger protein RIN ZF","NP_079500.2,zinc finger and BTB domain-containing protein 46","PF13909,C2H2-type zinc-finger domain;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding","-"]
["PPP6R2",3.285109507,1.592680795,1.041490335,3.787244502,0.006216513,0.012472552,"ENSG00000100239","G3RB43,Protein phosphatase 6 regulatory subunit 2","XP_018873891.1,serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2","PF04499,SIT4 phosphatase-associated protein","IPR016024,Armadillo-type fold;IPR007587,SIT4 phosphatase-associated protein family","-","-","-"]
["CENPB",120.6531654,58.61022187,1.041488176,7.996664799,{"v":1.97e-06,"d":"1.97E-06"},{"v":8.78e-06,"d":"8.78E-06"},"ENSG00000125817","I2CTV5,Major centromere autoantigen B","-","PF09026,Centromere protein B dimerisation domain;PF03184,superfamily endonuclease;PF03221,Tc5 transposase DNA-binding domain;PF04218,CENP-B N-terminal DNA-binding domain","IPR009057,Homeobox-like domain superfamily;IPR015115,Centromere protein CENP-B, C-terminal domain;IPR034882,CENP-B, dimerisation domain superfamily;IPR006600,HTH CenpB-type DNA-binding domain;IPR007889,DNA binding HTH domain, Psq-type;IPR033062,Major centromere autoantigen B;IPR004875,DDE superfamily endonuclease domain","ENOG4110CDI,-;KOG3105,DNA-binding centromere protein B (CENP-B)","GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0000775,cellular_component,chromosome, centromeric region;GO:0003696,molecular_function,satellite DNA binding;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding","-"]
["COL4A5",6.793892918,3.299883631,1.040938419,5.489371358,0.000131627,0.000388318,"ENSG00000188153","A7MBN3,Collagen, type IV, alpha 5","NP_000486.1,collagen alpha-5(IV) chain isoform 1 precursor;NP_203699.1,collagen alpha-5(IV) chain isoform 2 precursor","PF01391,Collagen triple helix repeat (20 copies);PF01413,C-terminal tandem repeated domain in type 4 procollagen","IPR008160,Collagen triple helix repeat;IPR016187,C-type lectin fold;IPR036954,Collagen IV, non-collagenous domain superfamily;IPR001442,Collagen IV, non-collagenous","ENOG410XNMM,-;KOG3544,Collagens (type IV and type XIII), and related proteins","GO:0005604,cellular_component,basement membrane;GO:0005578,,;GO:0005201,molecular_function,extracellular matrix structural constituent;GO:0005576,cellular_component,extracellular region;GO:0005581,cellular_component,collagen trimer","K06237,ko04974,Protein digestion and absorption;K06237,ko04510,Focal adhesion;K06237,ko04933,AGE-RAGE signaling pathway in diabetic complications;K06237,ko05200,Pathways in cancer;K06237,ko05222,Small cell lung cancer;K06237,ko04151,PI3K-Akt signaling pathway;K06237,ko04512,ECM-receptor interaction;K06237,ko05146,Amoebiasis"]
["PES1",35.95512404,17.4725076,1.040790219,6.937599611,{"v":7.39e-06,"d":"7.39E-06"},{"v":2.9E-5,"d":"2.90E-05"},"ENSG00000100029","B2RDF2,Pescadillo homolog","NP_055118.1,pescadillo homolog isoform 1","PF16589,BRCT domain, a BRCA1 C-terminus domain;PF06732,Pescadillo N-terminus","IPR010613,Pescadillo;IPR036420,BRCT domain superfamily;IPR001357,BRCT domain","KOG2481,Protein required for normal rRNA processing;COG5163,Protein required for biogenesis of the 60S ribosomal subunit","GO:0042254,biological_process,ribosome biogenesis;GO:0005829,cellular_component,cytosol;GO:0030687,cellular_component,preribosome, large subunit precursor;GO:0005730,cellular_component,nucleolus;GO:0005694,cellular_component,chromosome;GO:0000466,biological_process,maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0007000,biological_process,nucleolus organization;GO:0043021,molecular_function,ribonucleoprotein complex binding;GO:0070545,cellular_component,PeBoW complex;GO:0033365,biological_process,protein localization to organelle;GO:0000793,cellular_component,condensed chromosome;GO:0042273,biological_process,ribosomal large subunit biogenesis;GO:0005654,cellular_component,nucleoplasm;GO:0005634,cellular_component,nucleus;GO:0006364,biological_process,rRNA processing;GO:0000463,biological_process,maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","-"]
["URI1",22.33838996,10.85777248,1.04036452,6.507832791,{"v":1.6e-05,"d":"1.60E-05"},{"v":5.83e-05,"d":"5.83E-05"},"ENSG00000105176","H2R676,Uncharacterized protein","-","PF02996,Prefoldin subunit","-","-","-","-"]
["HEY1",27.11101287,13.17953214,1.039981157,6.043165564,{"v":3.97e-05,"d":"3.97E-05"},0.000132055,"ENSG00000164683","G3R3A1,Hes related family bHLH transcription factor with YRPW motif 1","XP_018888431.1,-","PF00010,Helix-loop-helix DNA-binding domain;PF07527,Hairy Orange","IPR003650,Orange domain;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily","-","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0046983,molecular_function,protein dimerization activity;GO:2000678,biological_process,negative regulation of transcription regulatory region DNA binding;GO:0003677,molecular_function,DNA binding;GO:2000820,biological_process,negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0045746,biological_process,negative regulation of Notch signaling pathway;GO:0001525,biological_process,angiogenesis;GO:0007219,biological_process,Notch signaling pathway;GO:0006351,biological_process,transcription, DNA-templated;GO:0000989,molecular_function,transcription factor activity, transcription factor binding;GO:0035939,molecular_function,microsatellite binding;GO:0005634,cellular_component,nucleus","-"]
["RAB2A",21.20929844,10.31554532,1.039439689,6.491242243,{"v":1.54e-05,"d":"1.54E-05"},{"v":5.62e-05,"d":"5.62E-05"},"ENSG00000104388","A0A1U7Q7J7,ras-related protein Rab-2A","XP_005066789.1,-","-","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity","-"]
["RP11-6N17.9",22.30060495,10.82713992,1.038343634,3.359229097,0.016842613,0.030237414,"ENSG00000263798","H2RGL6,Uncharacterized protein","-","PF05600,Protein of unknown function (DUF773)","IPR008491,CDK5 regulatory subunit-associated protein 3","KOG2607,CDK5 activator-binding protein;ENOG410XSWB,-","GO:0007346,biological_process,regulation of mitotic cell cycle;GO:0012505,cellular_component,endomembrane system;GO:0000079,biological_process,regulation of cyclin-dependent protein serine/threonine kinase activity","-"]
["ZNF780A",1.608485681,0.780933951,1.038343634,3.359229097,0.016842613,0.030237414,"ENSG00000197782","H2NYU4,Zinc finger protein 780A","XP_009230880.1,-;XP_009230879.1,zinc finger protein 780A isoform X2","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["ATRIP",2.361047292,1.146309235,1.038343634,3.359229097,0.016842613,0.030237414,"ENSG00000282827","A0A024R2U4,Three prime repair exonuclease 1, isoform CRA_b","NP_569055.1,ATR-interacting protein isoform 1","-","IPR033349,ATR-interacting protein","ENOG410IHIV,-;ENOG41107QS,-","GO:0004527,molecular_function,exonuclease activity;GO:0005634,cellular_component,nucleus;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0000077,biological_process,DNA damage checkpoint","K10905,ko03460,Fanconi anemia pathway"]
["XPNPEP1",2.519753447,1.224269336,1.038254586,3.731489151,0.008369844,0.016258421,"ENSG00000108039","K7AEW1,X-prolyl aminopeptidase","XP_009457448.1,xaa-Pro aminopeptidase 1 isoform X1","PF16188,C-terminal region of peptidase_M24;PF01321,Creatinase/Prolidase N-terminal domain;PF00557,Metallopeptidase family M24;PF16189,Creatinase/Prolidase N-terminal domain","IPR036005,Creatinase/aminopeptidase-like;IPR032416,Peptidase M24, C-terminal domain;IPR001131,Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site;IPR033740,Aminopeptidase P;IPR029149,Creatinase/Aminopeptidase P/Spt16, N-terminal;IPR000994,Peptidase M24;IPR000587,Creatinase, N-terminal","COG0006,Xaa-Pro aminopeptidase;KOG2413,Xaa-Pro aminopeptidase","GO:0070006,molecular_function,metalloaminopeptidase activity;GO:0004177,molecular_function,aminopeptidase activity;GO:0016787,molecular_function,hydrolase activity;GO:0046872,molecular_function,metal ion binding;GO:0006508,biological_process,proteolysis","-"]
["KBTBD4",5.105896522,2.480795314,1.038254586,3.731489151,0.008369844,0.016258421,"ENSG00000123444","A0A075B6T4,Kelch repeat and BTB domain-containing protein 4","NP_001305647.1,kelch repeat and BTB domain-containing protein 4 isoform e","PF13964,Kelch motif;PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch","IPR015915,Kelch-type beta propeller;IPR011705,BTB/Kelch-associated;IPR017096,BTB-kelch protein;IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily","KOG4441,Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes;ENOG410XNX8,-","-","-"]
["EML3",3.070978199,1.492092191,1.038254586,3.731489151,0.008369844,0.016258421,"ENSG00000149499","B4DL97,cDNA FLJ56458, highly similar to Homo sapiens echinoderm microtubule associated protein like 3","NP_001287723.1,echinoderm microtubule-associated protein-like 3 isoform 2","PF03451,HELP motif;PF00400,WD domain, G-beta repeat","IPR005108,HELP;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR036322,WD40-repeat-containing domain superfamily;IPR017986,WD40-repeat-containing domain","ENOG410XNTQ,-;KOG2106,Uncharacterized conserved protein, contains HELP and WD40 domains","-","-"]
["PHKA1",2.655066191,1.290013563,1.038254586,3.731489151,0.008369844,0.016258421,"ENSG00000067177","A6NMN0,Phosphorylase b kinase regulatory subunit","-","PF00723,lycosyl hydrolases family 15","IPR012341,Six-hairpin glycosidase-like superfamily;IPR008928,Six-hairpin glycosidase superfamily;IPR008734,Phosphorylase kinase alpha/beta subunit;IPR011613,Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family","KOG3635,Phosphorylase kinase;ENOG410XPJZ,-","GO:0005977,biological_process,glycogen metabolic process;GO:0005975,biological_process,carbohydrate metabolic process;GO:0005516,molecular_function,calmodulin binding;GO:0003824,molecular_function,catalytic activity;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane","-"]
["2020-03-05",4.511332639,2.192911657,1.038199889,4.026658304,0.003799778,0.008042855,"ENSG00000198060","A0A287DE71,Membrane associated ring-CH-type finger 5","XP_005333789.1,-","-","IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011016,Zinc finger, RING-CH-type;IPR033275,E3 ubiquitin-protein ligase MARCH-like","-","GO:0008270,molecular_function,zinc ion binding;GO:0046872,molecular_function,metal ion binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["MMS19",5.643180064,2.745000651,1.038115993,4.662702089,0.000943825,2.28612E-3,"ENSG00000155229","G3QKT3,MMS19 homolog, cytosolic iron-sulfur assembly component","XP_004049938.1,MMS19 nucleotide excision repair protein homolog isoform X1","PF14500,os2-interacting transcription regulator of RNA-Pol-II;PF12460,RNAPII transcription regulator C-terminal","IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR024687,MMS19, C-terminal","-","-","-"]
["SIN3B",3.760619824,1.829270686,1.038115993,4.662702089,0.000943825,2.28612E-3,"ENSG00000127511","H2Q9U2,Uncharacterized protein","XP_512485.2,paired amphipathic helix protein Sin3b isoform X1","PF02671,Paired amphipathic helix repeat;PF16879,C-terminal domain of Sin3a protein;PF08295,Sin3 family co-repressor","IPR031693,Sin3, C-terminal;IPR013194,Histone deacetylase interacting domain;IPR036600,Paired amphipathic helix superfamily;IPR003822,Paired amphipathic helix","KOG4204,Histone deacetylase complex, SIN3 component;COG5602,Histone deacetylase complex, SIN3 component","GO:0016580,cellular_component,Sin3 complex;GO:0001741,cellular_component,XY body;GO:0000806,cellular_component,Y chromosome;GO:0005737,cellular_component,cytoplasm;GO:0004407,molecular_function,histone deacetylase activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003714,molecular_function,transcription corepressor activity;GO:0003682,molecular_function,chromatin binding;GO:0016575,biological_process,histone deacetylation;GO:0030849,cellular_component,autosome;GO:0001106,molecular_function,RNA polymerase II transcription corepressor activity;GO:0005634,cellular_component,nucleus;GO:0000805,cellular_component,X chromosome","-"]
["FKBP1A",40.72851541,19.83527258,1.037472892,6.301484705,{"v":2.3E-5,"d":"2.30E-05"},{"v":8.06e-05,"d":"8.06E-05"},"ENSG00000088832","A0A087WZM5,Peptidylprolyl isomerase","-","PF00254,KBP-type peptidyl-prolyl cis-trans isomerase","IPR001179,FKBP-type peptidyl-prolyl cis-trans isomerase domain;IPR023566,Peptidyl-prolyl cis-trans isomerase, FKBP-type","KOG0544,FKBP-type peptidyl-prolyl cis-trans isomerase;COG0545,FKBP-type peptidyl-prolyl cis-trans isomerases 1","GO:0003755,molecular_function,peptidyl-prolyl cis-trans isomerase activity;GO:0016853,molecular_function,isomerase activity;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0000413,biological_process,protein peptidyl-prolyl isomerization","-"]
["VAPA",16.25042913,7.915775146,1.037404519,7.173881424,{"v":5.44e-06,"d":"5.44E-06"},{"v":2.19E-5,"d":"2.19E-05"},"ENSG00000101558","H2QE90,Uncharacterized protein","-","PF00635,MSP (Major sperm protein) domain","-","-","-","-"]
["PCM1",13.59498374,6.623587813,1.03712355,7.198464349,{"v":5.33e-06,"d":"5.33E-06"},{"v":2.15e-05,"d":"2.15E-05"},"ENSG00000078674","D3DSQ0,Pericentriolar material 1, isoform CRA_a","-","PF15717,Pericentriolar material 1 C terminus","IPR024138,Pericentriolar material 1 protein;IPR031446,Pericentriolar material 1 protein, C-terminal","ENOG410IEGR,-;ENOG410YNFX,-","GO:0071539,biological_process,protein localization to centrosome;GO:0034454,biological_process,microtubule anchoring at centrosome;GO:0060271,biological_process,cilium assembly;GO:0005813,cellular_component,centrosome","-"]
["RNPEP",13.92407865,6.78119231,1.036892391,5.202861393,0.00026245,0.000724088,"ENSG00000176393","G3RE55,Arginyl aminopeptidase","XP_004028200.1,aminopeptidase B isoform X1","PF01433,Peptidase family M1 domain;PF09127,Leukotriene A4 hydrolase, C-terminal","IPR027268,Peptidase M4/M1, CTD superfamily;IPR038502,Peptidase M1 LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily;IPR001930,Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase;IPR016024,Armadillo-type fold;IPR014782,Peptidase M1, membrane alanine aminopeptidase, N-terminal;IPR015211,Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal;IPR015571,Peptidase M1, aminopeptidase B;IPR034015,Leukotriene A4 hydrolase-like","-","GO:0006508,biological_process,proteolysis;GO:0008237,molecular_function,metallopeptidase activity;GO:0004177,molecular_function,aminopeptidase activity;GO:0008270,molecular_function,zinc ion binding;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space","-"]
["PPP2R2A",10.57588009,5.15547103,1.035975563,5.9731847,{"v":4.83e-05,"d":"4.83E-05"},0.0001576,"ENSG00000221914","G7N0R1,Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B","-","-","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR018067,Protein phosphatase 2A regulatory subunit PR55, conserved site;IPR000009,Protein phosphatase 2A regulatory subunit PR55","-","GO:0043666,biological_process,regulation of phosphoprotein phosphatase activity;GO:0019888,molecular_function,protein phosphatase regulator activity;GO:0000159,cellular_component,protein phosphatase type 2A complex","-"]
["CLUH",7.50236401,3.656534097,1.035860536,5.297009478,0.00021518,6.05402E-4,"ENSG00000132361","K6ZUB7,Clustered mitochondria protein homolog","XP_016786676.1,clustered mitochondria protein homolog isoform X4","PF12807,Translation initiation factor eIF3 subunit 135;PF13236,Clustered mitochondria;PF15044,Mitochondrial function, CLU-N-term;PF13424,Tetratricopeptide repeat","IPR033646,CLU central domain;IPR028275,Clustered mitochondria protein, N-terminal;IPR025697,CLU domain;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR027523,Clustered mitochondria protein","-","GO:0005737,cellular_component,cytoplasm;GO:0003723,molecular_function,RNA binding;GO:0007005,biological_process,mitochondrion organization;GO:0048312,biological_process,intracellular distribution of mitochondria","-"]
["KIAA0391",3.46905397,1.689470642,1.035816113,4.231771056,0.002455862,0.005430365,"ENSG00000100890","H2Q865,KIAA0391","XP_009425958.1,-;XP_009425956.1,-;XP_009425957.1,-;XP_009425955.1,mitochondrial ribonuclease P protein 3 isoform X1;XP_009425959.1,-","PF16953,Protein-only RNase P","IPR033495,Mitochondrial ribonuclease P catalytic subunit;IPR031595,Protein-only RNase P, C-terminal;IPR011990,Tetratricopeptide-like helical domain superfamily","ENOG4111GT9,-;ENOG410IE4T,-","GO:0042645,cellular_component,mitochondrial nucleoid;GO:0004526,molecular_function,ribonuclease P activity;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0001682,biological_process,tRNA 5'-leader removal;GO:0008033,biological_process,tRNA processing;GO:0090501,biological_process,RNA phosphodiester bond hydrolysis;GO:0005739,cellular_component,mitochondrion","-"]
["RFC1",10.61195346,5.17389024,1.035636776,5.74987574,{"v":7.27e-05,"d":"7.27E-05"},0.000227327,"ENSG00000035928","H2QPC6,Replication factor C subunit 1","XP_016806944.1,replication factor C subunit 1 isoform X2","PF08519,Replication factor RFC1 C terminal domain;PF00004,ATPase family associated with various cellular activities (AAA);PF00533,BRCA1 C Terminus (BRCT) domain","IPR001357,BRCT domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR012178,Replication factor C subunit 1;IPR008921,DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal;IPR013725,DNA replication factor RFC1, C-terminal;IPR003593,AAA+ ATPase domain;IPR003959,ATPase, AAA-type, core;IPR036420,BRCT domain superfamily","ENOG410IPR8,-;COG5275,BRCT domain type II","GO:0003689,molecular_function,DNA clamp loader activity;GO:0003677,molecular_function,DNA binding;GO:0000166,molecular_function,nucleotide binding;GO:0005663,cellular_component,DNA replication factor C complex;GO:0005524,molecular_function,ATP binding;GO:0006281,biological_process,DNA repair;GO:0006260,biological_process,DNA replication;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["GBA",5.532925534,2.6946007,1.035386253,3.979628686,0.004986264,0.01024696,"ENSG00000177628","A0A068F658,Glucosylceramidase","NP_001005741.1,-;NP_000148.2,glucosylceramidase isoform 1 precursor;NP_001005742.1,-","PF17189,lycosyl hydrolase family 30 beta sandwich domain;PF02055,lycosyl hydrolase family 30 TIM-barrel domain","IPR033452,Glycosyl hydrolase family 30, beta sandwich domain;IPR017853,Glycoside hydrolase superfamily;IPR033453,Glycosyl hydrolase family 30, TIM-barrel domain;IPR001139,Glycoside hydrolase family 30;IPR013780,Glycosyl hydrolase, all-beta","KOG2566,Beta-glucocerebrosidase;COG5520,O-Glycosyl hydrolase","GO:0006629,biological_process,lipid metabolic process;GO:0006665,biological_process,sphingolipid metabolic process;GO:0032269,biological_process,negative regulation of cellular protein metabolic process;GO:0005102,molecular_function,signaling receptor binding;GO:0043589,biological_process,skin morphogenesis;GO:0009267,biological_process,cellular response to starvation;GO:0071548,biological_process,response to dexamethasone;GO:0005615,cellular_component,extracellular space;GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0016787,molecular_function,hydrolase activity;GO:0051246,biological_process,regulation of protein metabolic process;GO:0032436,biological_process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1903052,biological_process,positive regulation of proteolysis involved in cellular protein catabolic process;GO:0033561,biological_process,regulation of water loss via skin;GO:1901805,biological_process,beta-glucoside catabolic process;GO:0006680,biological_process,glucosylceramide catabolic process;GO:0043627,biological_process,response to estrogen;GO:1905037,biological_process,autophagosome organization;GO:1904925,biological_process,positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization;GO:0008152,biological_process,metabolic process;GO:0005765,cellular_component,lysosomal membrane;GO:0009268,biological_process,response to pH;GO:0043202,cellular_component,lysosomal lumen;GO:0005764,cellular_component,lysosome;GO:0004348,molecular_function,glucosylceramidase activity;GO:0097066,biological_process,response to thyroid hormone;GO:0032463,biological_process,negative regulation of protein homooligomerization;GO:0033574,biological_process,response to testosterone","K01201,ko00600,Sphingolipid metabolism;K01201,ko00511,Other glycan degradation;K01201,ko04142,Lysosome"]
["HOXC10",8.658992857,4.217032755,1.035386253,3.979628686,0.004986264,0.01024696,"ENSG00000180818","Q53XI4,Homeo box C10","NP_059105.2,homeobox protein Hox-C10","PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR020479,Homeobox domain, metazoa;IPR009057,Homeobox-like domain superfamily","KOG0487,Transcription factor Abd-B, contains HOX domain;ENOG4111FJP,-","GO:0003677,molecular_function,DNA binding;GO:0001501,biological_process,skeletal system development;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0009954,biological_process,proximal/distal pattern formation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0030326,biological_process,embryonic limb morphogenesis;GO:0021520,biological_process,spinal cord motor neuron cell fate specification;GO:0009952,biological_process,anterior/posterior pattern specification;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0050905,biological_process,neuromuscular process;GO:0005654,cellular_component,nucleoplasm","-"]
["DSN1",7.369153833,3.588865773,1.035386253,3.979628686,0.004986264,0.01024696,"ENSG00000149636","A8K3X3,cDNA FLJ77685","NP_001138788.1,-","PF08202,Mis12-Mtw1 protein family","IPR013218,Kinetochore-associated protein Dsn1/Mis13","ENOG410YXFH,-;ENOG410IHC2,-","GO:0007059,biological_process,chromosome segregation;GO:0051301,biological_process,cell division;GO:0000444,cellular_component,MIS12/MIND type complex","-"]
["SIRT5",5.473954479,2.668843183,1.034905729,4.770468239,0.000850314,0.002087239,"ENSG00000124523","A0A024R012,NAD-dependent protein deacylase sirtuin-5, mitochondrial","NP_036373.1,NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1;XP_005249025.1,-","PF02146,Sir2 family","IPR003000,Sirtuin family;IPR026591,Sirtuin, catalytic core small domain superfamily;IPR027546,Sirtuin, class III;IPR026590,Sirtuin family, catalytic core domain;IPR029035,DHS-like NAD/FAD-binding domain superfamily","KOG2684,Sirtuin 5 and related class III sirtuins (SIR2 family);COG0846,NAD-dependent protein deacetylases, SIR2 family","GO:0036049,biological_process,peptidyl-lysine desuccinylation;GO:0061698,biological_process,protein deglutarylation;GO:0036047,biological_process,peptidyl-lysine demalonylation;GO:0005634,cellular_component,nucleus;GO:0031667,biological_process,response to nutrient levels;GO:0061697,molecular_function,protein-glutaryllysine deglutarylase activity;GO:0010667,biological_process,negative regulation of cardiac muscle cell apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0006476,biological_process,protein deacetylation;GO:0005739,cellular_component,mitochondrion;GO:0036055,molecular_function,protein-succinyllysine desuccinylase activity;GO:0061699,biological_process,peptidyl-lysine deglutarylation;GO:0036054,molecular_function,protein-malonyllysine demalonylase activity;GO:0070403,molecular_function,NAD+ binding;GO:0036046,biological_process,protein demalonylation;GO:0016787,molecular_function,hydrolase activity;GO:0005829,cellular_component,cytosol;GO:0008270,molecular_function,zinc ion binding;GO:0036048,biological_process,protein desuccinylation;GO:0046872,molecular_function,metal ion binding;GO:0010566,biological_process,regulation of ketone biosynthetic process;GO:0034979,molecular_function,NAD-dependent protein deacetylase activity;GO:0005743,cellular_component,mitochondrial inner membrane","-"]
["RTKN2",1.691169866,0.823619887,1.034742161,3.673470729,0.009186286,0.017654037,"ENSG00000182010","K7CNK1,Rhotekin 2","XP_009456805.1,rhotekin-2 isoform X1","PF08174,Cell division protein anillin;PF00169,PH domain","IPR030469,Rhotekin-2;IPR012966,Anillin homology domain;IPR011072,HR1 rho-binding domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily","ENOG410IIHF,-;ENOG410ZX8Y,-","GO:0030097,biological_process,hemopoiesis;GO:0007165,biological_process,signal transduction","-"]
["SNAPC3",2.41581237,1.176529426,1.034742161,3.673470729,0.009186286,0.017654037,"ENSG00000164975","H2R1P5,Small nuclear RNA activating complex, polypeptide 3, 50kDa","XP_528547.1,-","PF12251,snRNA-activating protein of 50kDa MW C terminal","IPR022042,snRNA-activating protein complex, subunit 3","ENOG411090A,-;KOG2664,Small nuclear RNA activating protein complex - 50kD subunit (SNAP50)","GO:0003677,molecular_function,DNA binding;GO:0005730,cellular_component,nucleolus;GO:0009301,biological_process,snRNA transcription;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["TNIP2",19.00742042,9.271192042,1.034715602,5.277770379,0.00022219,6.21646E-4,"ENSG00000168884","K7CDD7,TNFAIP3 interacting protein 2","XP_016806664.1,TNFAIP3-interacting protein 2","PF16516,Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator;PF12180,TSG101 and ALIX binding domain of CEP55","IPR032419,NF-kappa-B essential modulator NEMO, CC2-LZ domain;IPR034735,NEMO, Zinc finger;IPR022008,TSG101 and ALIX binding domain of CEP55","ENOG410IEB1,-;ENOG410XRZP,-","GO:0070530,molecular_function,K63-linked polyubiquitin modification-dependent protein binding","-"]
["GRINA",20.20337603,9.854539702,1.034715602,5.277770379,0.00022219,6.21646E-4,"ENSG00000178719","K7BS10,Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1","XP_016814417.1,-;XP_016814416.1,protein lifeguard 1 isoform X2","PF01027,Inhibitor of apoptosis-promoting Bax1","IPR006214,Bax inhibitor 1-related","COG0670,Integral membrane protein, interacts with FtsH;KOG2322,N-methyl-D-aspartate receptor glutamate-binding subunit","GO:0005794,cellular_component,Golgi apparatus;GO:0044325,molecular_function,ion channel binding;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016020,cellular_component,membrane;GO:0032469,biological_process,endoplasmic reticulum calcium ion homeostasis;GO:1902236,biological_process,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0016021,cellular_component,integral component of membrane","-"]
["MRPL16",12.129184,5.915544363,1.034009638,4.41121187,1.662604E-3,0.003827248,"ENSG00000166902","H2Q3R6,Mitochondrial ribosomal protein L16","XP_508452.2,39S ribosomal protein L16, mitochondrial","PF00252,Ribosomal protein L16p/L10e","IPR036920,Ribosomal protein L10e/L16 superfamily;IPR016180,Ribosomal protein L10e/L16;IPR000114,Ribosomal protein L16","KOG3422,Mitochondrial ribosomal protein L16;COG0197,Ribosomal protein L16/L10E","GO:0019843,molecular_function,rRNA binding;GO:0003735,molecular_function,structural constituent of ribosome;GO:0005840,cellular_component,ribosome;GO:0032543,biological_process,mitochondrial translation;GO:0005739,cellular_component,mitochondrion;GO:0005762,cellular_component,mitochondrial large ribosomal subunit;GO:0006412,biological_process,translation;GO:0030529,,","K02878,ko03010,Ribosome"]
["HLTF",4.572605719,2.230113089,1.034009638,4.41121187,1.662604E-3,0.003827248,"ENSG00000071794","A8K5B6,cDNA FLJ76830, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3","NP_001305864.1,-","PF00271,Helicase conserved C-terminal domain;PF00176,SNF2 family N-terminal domain;PF13920,Zinc finger, C3HC4 type (RING finger);PF08797,HIRAN domain","IPR017907,Zinc finger, RING-type, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR014905,HIRAN domain;IPR001841,Zinc finger, RING-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR001650,Helicase, C-terminal","COG0553,Superfamily II DNA/RNA helicases, SNF2 family;KOG1001,Helicase-like transcription factor HLTF/DNA helicase RAD5, DEAD-box superfamily","GO:0003676,molecular_function,nucleic acid binding;GO:0005524,molecular_function,ATP binding;GO:0008270,molecular_function,zinc ion binding;GO:0016818,molecular_function,hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides","-"]
["ACAT2",6.407391685,3.124959583,1.034009638,4.41121187,1.662604E-3,0.003827248,"ENSG00000120437","Q59GW6,Acetyl-CoA acetyltransferase, cytosolic variant","-","PF00108,Thiolase, N-terminal domain;PF02803,Thiolase, C-terminal domain","IPR016039,Thiolase-like;IPR020610,Thiolase, active site;IPR020613,Thiolase, conserved site;IPR020617,Thiolase, C-terminal;IPR002155,Thiolase;IPR020616,Thiolase, N-terminal","KOG1391,Acetyl-CoA acetyltransferase;COG0183,Acetyl-CoA acetyltransferase","GO:0016747,molecular_function,transferase activity, transferring acyl groups other than amino-acyl groups;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0008152,biological_process,metabolic process","-"]
["SHTN1",8.3250804,4.064171322,1.033712119,5.637157692,1.08035E-4,0.000324912,"ENSG00000187164","K7C096,KIAA1598","XP_521613.3,shootin-1 isoform X1","-","IPR024849,Shootin-1","ENOG4111HDU,-;ENOG410IFIH,-","-","-"]
["VKORC1",5.527369881,2.69189503,1.033670528,3.28347785,0.023697608,0.040761609,"ENSG00000167397","H2QAZ5,Vitamin K epoxide reductase complex, subunit 1","NP_001238859.1,-","PF07884,Vitamin K epoxide reductase family","IPR012932,Vitamin K epoxide reductase;IPR038354,VKOR domain superfamily","ENOG4111UX7,-;ENOG410J0HT,-","GO:0017187,biological_process,peptidyl-glutamic acid carboxylation;GO:0047057,molecular_function,vitamin-K-epoxide reductase (warfarin-sensitive) activity;GO:0017144,biological_process,drug metabolic process;GO:0042373,biological_process,vitamin K metabolic process;GO:0005783,cellular_component,endoplasmic reticulum;GO:0007596,biological_process,blood coagulation;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane","K05357,ko00130,Ubiquinone and other terpenoid-quinone biosynthesis"]
["GATSL2",8.88515584,4.327176824,1.033670528,3.28347785,0.023697608,0.040761609,"ENSG00000274070","H9ZD32,GATS protein like 2","NP_001253033.1,-","PF13840,ACT domain","IPR027795,CASTOR,  ACT domain;IPR026249,CASTOR family","ENOG410IJ9B,-;ENOG4111D5N,-","GO:0061700,cellular_component,GATOR2 complex;GO:0005829,cellular_component,cytosol;GO:1904262,biological_process,negative regulation of TORC1 signaling;GO:0042802,molecular_function,identical protein binding","-"]
["FANCG",3.350987108,1.631970673,1.033670528,3.28347785,0.023697608,0.040761609,"ENSG00000221829","Q53XM5,Fanconi anemia complementation group G isoform 1","NP_004620.1,Fanconi anemia group G protein","-","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat","ENOG4111KPJ,-;ENOG410IE5D,-","GO:0001541,biological_process,ovarian follicle development;GO:0007286,biological_process,spermatid development;GO:0005730,cellular_component,nucleolus;GO:0009314,biological_process,response to radiation;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol","K10894,ko03460,Fanconi anemia pathway"]
["PHF3",17.2523559,8.429961441,1.03290527,7.067290044,{"v":7.15e-06,"d":"7.15E-06"},{"v":2.81e-05,"d":"2.81E-05"},"ENSG00000118482","H2R1J9,PHD finger protein 3","XP_003317935.1,PHD finger protein 3 isoform X1;XP_009438404.1,-","PF07500,Transcription factor S-II (TFIIS), central domain;PF00628,PHD-finger;PF07744,SPOC domain","IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR036575,Transcription elongation factor S-II, central domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR012921,Spen paralogue and orthologue SPOC, C-terminal;IPR003618,Transcription elongation factor S-II, central domain;IPR019787,Zinc finger, PHD-finger;IPR019786,Zinc finger, PHD-type, conserved site","ENOG4111K1A,-;ENOG410IQ8Y,-","GO:0006351,biological_process,transcription, DNA-templated;GO:0046872,molecular_function,metal ion binding","-"]
["SLC9A3R2",11.90645236,5.814872406,1.03269495,5.011821444,0.000394433,1.046768E-3,"ENSG00000065054","Q6NTG0,SLC9A3R2 protein","-","PF09007,BP50, C-terminal;PF00595,PDZ domain (Also known as DHR or GLGF)","IPR017300,Na(+)/H(+) exchange regulatory cofactor NHERF;IPR001478,PDZ domain;IPR031197,Na(+)/H(+) exchange regulatory cofactor NHERF-2;IPR036034,PDZ superfamily;IPR015098,EBP50, C-terminal","ENOG4111V58,-;ENOG410ITAC,-","GO:0032947,molecular_function,protein-containing complex scaffold activity","-"]
["LRRD1",5.794887011,2.830106531,1.03269495,5.011821444,0.000394433,1.046768E-3,"ENSG00000240720","H2RFM8,Leucine rich repeats and death domain containing 1","XP_527815.1,leucine-rich repeat and death domain-containing protein 1 isoform X1;XP_016813228.1,-;XP_016813227.1,-;XP_016800622.1,-","PF13855,Leucine rich repeat;PF00560,Leucine Rich Repeat","IPR001611,Leucine-rich repeat;IPR000488,Death domain;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily","KOG0619,FOG: Leucine rich repeat;COG4886,Leucine-rich repeat (LRR) protein","GO:0005737,cellular_component,cytoplasm;GO:0045199,biological_process,maintenance of epithelial cell apical/basal polarity;GO:0016323,cellular_component,basolateral plasma membrane;GO:0007165,biological_process,signal transduction","-"]
["FAR1",2.595884804,1.266796415,1.032373196,3.931001455,0.005411469,0.01101667,"ENSG00000197601","G3QFT4,Fatty acyl-CoA reductase","-","PF03015,Male sterility protein;PF07993,Male sterility protein;PF01370,NAD dependent epimerase/dehydratase family","IPR033640,Fatty acyl-CoA reductase, C-terminal;IPR026055,Fatty acyl-CoA reductase","-","GO:0006629,biological_process,lipid metabolic process;GO:0016020,cellular_component,membrane;GO:0080019,molecular_function,fatty-acyl-CoA reductase (alcohol-forming) activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0102965,molecular_function,alcohol-forming fatty acyl-CoA reductase activity;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane","K13356,ko04146,Peroxisome;K13356,ko04212,Longevity regulating pathway - worm;K13356,ko00073,Cutin, suberine and wax biosynthesis"]
["SOD2",2.614125381,1.277171184,1.032330118,5.238502802,0.000301707,0.000820856,"ENSG00000112096","A0A0C4DFU2,Superoxide dismutase","-","PF00081,Iron/manganese superoxide dismutases, alpha-hairpin domain;PF02777,Iron/manganese superoxide dismutases, C-terminal domain","-","-","-","-"]
["PPP1R21",9.569733014,4.675047902,1.032139475,4.870723908,0.000609576,1.545842E-3,"ENSG00000162869","H2QHW3,KLRAQ motif containing 1","XP_001151290.1,protein phosphatase 1 regulatory subunit 21 isoform X1","PF10212,Predicted coiled-coil domain-containing protein;PF10205,Predicted coiled-coil domain-containing protein","IPR019348,Uncharacterised domain KLRAQ/TTKRSYEDQ, C-terminal;IPR019343,Uncharacterised domain KLRAQ/TTKRSYEDQ, N-terminal","KOG4421,Uncharacterized conserved protein;ENOG410YXM0,-","-","-"]
["ARAP1",7.105973871,3.473464082,1.031850861,5.606655633,0.000125515,0.000371651,"ENSG00000186635","K7DJU2,ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1","-","PF01412,Putative GTPase activating protein for Arf;PF00536,SAM domain (Sterile alpha motif);PF00620,RhoGAP domain;PF00788,Ras association (RalGDS/AF-6) domain;PF00169,PH domain","IPR037858,ARAP, RhoGAP domain;IPR037278,ARFGAP/RecO-like zinc finger;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR038508,ArfGAP domain superfamily;IPR000159,Ras-associating (RA) domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain;IPR001164,Arf GTPase activating protein;IPR001660,Sterile alpha motif domain","COG5347,GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport;KOG1117,Rho- and Arf-GTPase activating protein ARAP3","GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005547,molecular_function,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0007165,biological_process,signal transduction;GO:0005096,molecular_function,GTPase activator activity","-"]
["PCMTD2",4.474403271,2.185515725,1.031787145,4.375381276,0.002096443,0.004710045,"ENSG00000203880","H2QKU4,Protein-L-isoaspartate","XP_009435975.1,-;XP_003317122.1,-","PF01135,Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)","IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR000682,Protein-L-isoaspartate(D-aspartate) O-methyltransferase","COG2518,Protein-L-isoaspartate carboxylmethyltransferase;KOG1661,Protein-L-isoaspartate(D-aspartate) O-methyltransferase","GO:0004719,molecular_function,protein-L-isoaspartate (D-aspartate) O-methyltransferase activity;GO:0005737,cellular_component,cytoplasm;GO:0016740,molecular_function,transferase activity;GO:0006479,biological_process,protein methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0006464,biological_process,cellular protein modification process","-"]
["RP11-432B6.3",7.986010838,3.900755299,1.031787145,4.375381276,0.002096443,0.004710045,"ENSG00000248710","H3BRJ5,Uncharacterized protein","-","PF00643,B-box zinc finger;PF13445,RING-type zinc-finger","IPR017907,Zinc finger, RING-type, conserved site;IPR000315,B-box-type zinc finger;IPR036322,WD40-repeat-containing domain superfamily;IPR001841,Zinc finger, RING-type;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR001680,WD40 repeat;IPR027370,RING-type zinc-finger, LisH dimerisation motif;IPR017986,WD40-repeat-containing domain","KOG1524,WD40 repeat-containing protein CHE-2;COG2319,FOG: WD40 repeat;KOG2177,Predicted E3 ubiquitin ligase","GO:0030992,cellular_component,intraciliary transport particle B;GO:0005813,cellular_component,centrosome;GO:0005929,cellular_component,cilium;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular;GO:0060271,biological_process,cilium assembly;GO:0008270,molecular_function,zinc ion binding","-"]
["EPB41L4A-AS1",10.2255565,4.997259479,1.031453274,4.714268626,0.000851875,2.089502E-3,"-","-","-","-","-","-","-","-"]
["FXR1",45.78209537,22.39876213,1.03127056,8.685732893,{"v":1.43e-06,"d":"1.43E-06"},{"v":6.58e-06,"d":"6.58E-06"},"ENSG00000114416","G3R3A0,FMR1 autosomal homolog 1","-","PF16096,ragile X-related 1 protein C-terminal region 2;PF00013,KH domain;PF05641,Agenet domain;PF12235,ragile X-related 1 protein core C terminal;PF16097,ragile X-related 1 protein C-terminal region 3","IPR022034,Fragile X-related 1 protein, C-terminal core;IPR004088,K Homology domain, type 1;IPR004087,K Homology domain;IPR032172,Fragile X-related 1 protein, C-terminal region 1;IPR008395,Agenet-like domain;IPR036612,K Homology domain, type 1 superfamily","-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["ZNF131",5.744104031,2.808763679,1.031086866,5.218459663,0.000253635,0.00070278,"ENSG00000172262","G1RHG1,Zinc finger protein 131","XP_012363320.1,zinc finger protein 131 isoform X1","PF12874,Zinc-finger of C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR027758,Zinc finger protein 131;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0045111,cellular_component,intermediate filament cytoskeleton;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm","-"]
["WDR73",1.603460362,0.782906632,1.030915978,3.612996707,0.012497245,0.023266794,"ENSG00000177082","K7DF19,WD repeat domain 73","-","-","-","-","-","-"]
["RABL3",3.295241128,1.608936643,1.030915978,3.612996707,0.012497245,0.023266794,"ENSG00000144840","H2QN65,RAB, member of RAS oncogene family-like 3","XP_516675.2,-","PF08477,Ras of Complex, Roc, domain of DAPkinase","IPR027417,P-loop containing nucleoside triphosphate hydrolase","ENOG410YR8H,-;ENOG410IJY5,-","-","-"]
["GUF1",3.465404006,1.692020484,1.030915978,3.612996707,0.012497245,0.023266794,"ENSG00000151806","A0A024R9T3,Translation factor GUF1, mitochondrial","NP_068746.2,translation factor GUF1, mitochondrial isoform 1","PF06421,TP-binding protein LepA C-terminus;PF00009,longation factor Tu GTP binding domain;PF00679,longation factor G C-terminus;PF03144,longation factor Tu domain 2","IPR035647,EF-G domain III/V-like;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004161,Translation elongation factor EFTu-like, domain 2;IPR000795,Transcription factor, GTP-binding domain;IPR013842,GTP-binding protein LepA, C-terminal;IPR009000,Translation protein, beta-barrel domain superfamily;IPR031157,Tr-type G domain, conserved site;IPR006297,Elongation factor 4;IPR035654,Elongation factor 4, domain IV;IPR038363,LepA, C-terminal domain superfamily;IPR000640,Elongation factor EFG, domain V-like","KOG0462,Elongation factor-type GTP-binding protein;COG0481,Membrane GTPase LepA","GO:0016787,molecular_function,hydrolase activity;GO:0005525,molecular_function,GTP binding;GO:0043022,molecular_function,ribosome binding;GO:0005759,cellular_component,mitochondrial matrix;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding;GO:0006412,biological_process,translation;GO:0045727,biological_process,positive regulation of translation","-"]
["FAM73A",2.376086507,1.161200452,1.03069649,4.14924084,0.00339174,0.007241775,"ENSG00000180488","F8W7S1,Mitoguardin 1","NP_001257313.1,mitoguardin 1 isoform 2","PF10265,Mitoguardin","IPR019392,Mitoguardin","KOG3831,Uncharacterized conserved protein;ENOG410Y4ER,-","GO:0008053,biological_process,mitochondrial fusion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TMEM87A",4.021907895,1.965518196,1.03069649,4.14924084,0.00339174,0.007241775,"ENSG00000103978","H2Q991,Transmembrane protein 87A","XP_016782509.1,-","PF06814,Lung seven transmembrane receptor","IPR009637,Lung seven transmembrane receptor-like","ENOG410XS1Q,-;KOG2568,Predicted membrane protein","GO:0016021,cellular_component,integral component of membrane","-"]
["HAX1",56.85820648,27.82478443,1.030575383,6.524898487,{"v":1.78e-05,"d":"1.78E-05"},{"v":6.38e-05,"d":"6.38E-05"},"ENSG00000143575","A0A1D5QRD4,Uncharacterized protein","-","-","IPR017248,HS1-associating protein X-1","-","-","-"]
["HNRNPUL2-BSCL2",53.53387929,26.20652398,1.030284494,7.325244776,{"v":5.2e-06,"d":"5.20E-06"},{"v":2.11e-05,"d":"2.11E-05"},"ENSG00000234857","H3BQZ7,HCG2044799","-","PF02037,SAP domain;PF13671,AAA domain;PF00622,SPRY domain","IPR035778,Heterogeneous nuclear ribonucleoprotein U, SPRY domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001870,B30.2/SPRY domain;IPR036361,SAP domain superfamily;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR003877,SPRY domain;IPR003034,SAP domain","ENOG41101YN,-;ENOG410KD8N,-","-","-"]
["KNSTRN",17.22138437,8.429218346,1.029907929,5.575493397,0.000122119,0.000362393,"ENSG00000128944","G3QEQ5,Kinetochore localized astrin/SPAG5 binding protein","XP_004056025.1,small kinetochore-associated protein isoform X1","-","IPR033373,Small kinetochore-associated protein","-","GO:0000070,biological_process,mitotic sister chromatid segregation;GO:0000776,cellular_component,kinetochore;GO:0007051,biological_process,spindle organization;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0005829,cellular_component,cytosol;GO:0051988,biological_process,regulation of attachment of spindle microtubules to kinetochore;GO:0072686,cellular_component,mitotic spindle;GO:0007059,biological_process,chromosome segregation;GO:0035371,cellular_component,microtubule plus-end","-"]
["ASCC3",4.109147514,2.011061976,1.029808013,5.198133331,0.000296821,0.000808248,"ENSG00000112249","G3QJZ8,Activating signal cointegrator 1 complex subunit 3","XP_004044503.2,activating signal cointegrator 1 complex subunit 3 isoform X2","PF00271,Helicase conserved C-terminal domain;PF00270,AD/DEAH box helicase;PF02889,Sec63 Brl domain","IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR004179,Sec63 domain;IPR035892,C2 domain superfamily;IPR014756,Immunoglobulin E-set;IPR003593,AAA+ ATPase domain;IPR011545,DEAD/DEAH box helicase domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR001650,Helicase, C-terminal","-","GO:0003676,molecular_function,nucleic acid binding;GO:0005524,molecular_function,ATP binding","-"]
["RELL1",20.9774756,10.2657782,1.02973107,4.964449547,0.000489943,0.00126967,"ENSG00000181826","K7B0E5,RELT-like 1","XP_016806930.1,-","PF12606,Tumour necrosis factor receptor superfamily member 19","IPR022248,TNF receptor family, RELT","ENOG410IGV6,-;ENOG4111KWD,-","GO:0016020,cellular_component,membrane;GO:0005886,cellular_component,plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0015630,cellular_component,microtubule cytoskeleton","-"]
["ANAPC7",7.350239145,3.598899547,1.02906481,5.074920532,0.000384483,0.001022557,"ENSG00000196510","A0A024RBJ3,Anaphase promoting complex subunit 7, isoform CRA_b","NP_057322.2,anaphase-promoting complex subunit 7 isoform a","PF13181,Tetratricopeptide repeat;PF13432,Tetratricopeptide repeat","IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain","ENOG410XS2B,-;KOG1174,Anaphase-promoting complex (APC), subunit 7","-","K03354,ko04113,Meiosis - yeast;K03354,ko04120,Ubiquitin mediated proteolysis;K03354,ko04111,Cell cycle - yeast;K03354,ko04110,Cell cycle;K03354,ko04114,Oocyte meiosis;K03354,ko04914,Progesterone-mediated oocyte maturation;K03354,ko05166,HTLV-I infection"]
["PCBP2-OT1",49.90687799,24.43591794,1.028480576,4.505936432,0.00154018,3.567888E-3,"ENSG00000282977","B2M1R7,Poly","XP_017171987.1,-","PF00013,KH domain","IPR004087,K Homology domain;IPR004088,K Homology domain, type 1;IPR036612,K Homology domain, type 1 superfamily","KOG2190,PolyC-binding proteins alphaCP-1 and related KH domain proteins;ENOG410XNN8,-","GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding","-"]
["TMEM25",2.061509671,1.007465829,1.028433064,3.20347412,0.033557963,0.055389793,"ENSG00000149582","E9PKP3,Transmembrane protein 25","NP_001305684.1,transmembrane protein 25 isoform 6 precursor","PF08205,CD80-like C2-set immunoglobulin domain","IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR007110,Immunoglobulin-like domain","ENOG410ZNWF,-;ENOG410IF2Y,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["KDSR",1.227316353,0.599793105,1.028433064,3.20347412,0.033557963,0.055389793,"ENSG00000119537","H2QEM9,3-ketodihydrosphingosine reductase","-","PF08659,KR domain;PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase","IPR036291,NAD(P)-binding domain superfamily;IPR020904,Short-chain dehydrogenase/reductase, conserved site;IPR002347,Short-chain dehydrogenase/reductase SDR","KOG1210,Predicted 3-ketosphinganine reductase;ENOG410YF8M,-","GO:0047560,molecular_function,3-dehydrosphinganine reductase activity;GO:0030148,biological_process,sphingolipid biosynthetic process;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016491,molecular_function,oxidoreductase activity;GO:0055114,biological_process,oxidation-reduction process;GO:0006666,biological_process,3-keto-sphinganine metabolic process","-"]
["ZNF564",3.146904189,1.537901316,1.028433064,3.20347412,0.033557963,0.055389793,"ENSG00000249709","H2R1T8,Uncharacterized protein","XP_016790658.1,-;XP_512406.2,zinc finger protein 564 isoform X1","PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF01352,KRAB box;PF13912,C2H2-type zinc finger","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["PPM1A",5.806361057,2.845643747,1.028129527,5.704073428,{"v":9.41e-05,"d":"9.41E-05"},0.000285523,"ENSG00000100614","H2Q8E5,Uncharacterized protein","XP_001167412.2,-","PF00481,Protein phosphatase 2C;PF07830,Protein serine/threonine phosphatase 2C, C-terminal domain","IPR036457,PPM-type phosphatase domain superfamily;IPR000222,PPM-type phosphatase, divalent cation binding;IPR012911,Protein serine/threonine phosphatase 2C, C-terminal;IPR001932,PPM-type phosphatase domain;IPR036580,Phosphatase 2C, C-terminal domain superfamily;IPR015655,Protein phosphatase 2C family","COG0631,Serine/threonine protein phosphatase;KOG0697,Protein phosphatase 1B (formerly 2C)","GO:0043169,molecular_function,cation binding;GO:0016055,biological_process,Wnt signaling pathway;GO:0005886,cellular_component,plasma membrane;GO:0016311,biological_process,dephosphorylation;GO:0070412,molecular_function,R-SMAD binding;GO:0033192,molecular_function,calmodulin-dependent protein phosphatase activity;GO:0030145,molecular_function,manganese ion binding;GO:0004722,molecular_function,protein serine/threonine phosphatase activity;GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0030177,biological_process,positive regulation of Wnt signaling pathway;GO:0003824,molecular_function,catalytic activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0006470,biological_process,protein dephosphorylation;GO:0005829,cellular_component,cytosol;GO:0030512,biological_process,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0000287,molecular_function,magnesium ion binding;GO:0043124,biological_process,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035970,biological_process,peptidyl-threonine dephosphorylation;GO:0010991,biological_process,negative regulation of SMAD protein complex assembly;GO:0046872,molecular_function,metal ion binding;GO:0042347,-,-","K04457,ko04010,MAPK signaling pathway"]
["ABCB7",7.435620711,3.640704945,1.027897033,4.106121938,0.004388966,0.009146804,"ENSG00000131269","A0A0S2Z2Z3,ATP-binding cassette sub-family B member 7 isoform 1","NP_004290.2,ATP-binding cassette sub-family B member 7, mitochondrial isoform 1","PF00005,ABC transporter;PF00664,ABC transporter transmembrane region","IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR011527,ABC transporter type 1, transmembrane domain;IPR036640,ABC transporter type 1, transmembrane domain superfamily;IPR003593,AAA+ ATPase domain;IPR017871,ABC transporter, conserved site","-","GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0055085,biological_process,transmembrane transport;GO:0016887,molecular_function,ATPase activity;GO:0005739,cellular_component,mitochondrion;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0016020,cellular_component,membrane;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane","-"]
["NDUFA10",7.585151221,3.718362096,1.027795834,5.77119474,{"v":9.07e-05,"d":"9.07E-05"},0.000276133,"ENSG00000130414","G3QGG1,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial","-","PF01712,eoxynucleoside kinase","IPR015828,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial;IPR031314,Deoxynucleoside kinase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase","-","GO:0006120,biological_process,mitochondrial electron transport, NADH to ubiquinone;GO:0005747,cellular_component,mitochondrial respiratory chain complex I;GO:0005759,cellular_component,mitochondrial matrix;GO:0005739,cellular_component,mitochondrion;GO:0070469,cellular_component,respiratory chain;GO:0055114,biological_process,oxidation-reduction process","-"]
["CRAMP1",3.913710743,1.917533597,1.027710268,4.655780329,0.001099462,0.002633766,"ENSG00000007545","G3QTM8,Cramped chromatin regulator homolog 1","XP_004056999.1,protein cramped-like isoform X1","-","IPR001005,SANT/Myb domain;IPR017884,SANT domain","-","GO:0005634,cellular_component,nucleus","-"]
["CYTH2",3.446156278,1.688453971,1.027710268,4.655780329,0.001099462,0.002633766,"ENSG00000105443","A0A287CSY5,Uncharacterized protein","-","-","IPR035999,Sec7 domain superfamily;IPR011993,PH-like domain superfamily;IPR001849,Pleckstrin homology domain;IPR023394,Sec7, C-terminal domain superfamily;IPR000904,Sec7 domain","-","GO:0032012,biological_process,regulation of ARF protein signal transduction;GO:0005086,molecular_function,ARF guanyl-nucleotide exchange factor activity;GO:0065009,biological_process,regulation of molecular function","-"]
["PPARD",10.49577039,5.146161354,1.027137201,5.156598186,3.61097E-4,0.000965627,"ENSG00000112033","A0A024RCW6,Peroxisome proliferative activated receptor, delta, isoform CRA_a","XP_011513012.1,-;XP_016866461.1,-;NP_001165289.1,-;XP_011513011.1,-;XP_011513009.1,-;XP_016866462.1,-;NP_006229.1,peroxisome proliferator-activated receptor delta isoform 1;XP_006715183.1,-;XP_016866463.1,-;XP_016866460.1,-;XP_006715186.1,-;XP_005249250.1,-","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR003075,Peroxisome proliferator-activated receptor, beta;IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR003074,Peroxisome proliferator-activated receptor;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR013088,Zinc finger, NHR/GATA-type","KOG3575,FOG: Hormone receptors;ENOG410XRZC,-","GO:0006629,biological_process,lipid metabolic process;GO:0014823,biological_process,response to activity;GO:0046697,biological_process,decidualization;GO:0042127,biological_process,regulation of cell proliferation;GO:0048662,biological_process,negative regulation of smooth muscle cell proliferation;GO:0003677,molecular_function,DNA binding;GO:0006635,biological_process,fatty acid beta-oxidation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:1902894,biological_process,negative regulation of pri-miRNA transcription by RNA polymerase II;GO:0014912,biological_process,negative regulation of smooth muscle cell migration;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0046982,molecular_function,protein heterodimerization activity;GO:0045662,biological_process,negative regulation of myoblast differentiation;GO:0010033,biological_process,response to organic substance;GO:0009749,biological_process,response to glucose;GO:0005634,cellular_component,nucleus;GO:0009299,biological_process,mRNA transcription;GO:0031589,biological_process,cell-substrate adhesion;GO:0006029,biological_process,proteoglycan metabolic process;GO:0007566,biological_process,embryo implantation;GO:0008366,biological_process,axon ensheathment;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045684,biological_process,positive regulation of epidermis development;GO:0051546,biological_process,keratinocyte migration;GO:0033189,biological_process,response to vitamin A;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0000790,cellular_component,nuclear chromatin;GO:0043401,biological_process,steroid hormone mediated signaling pathway;GO:0050728,biological_process,negative regulation of inflammatory response;GO:0051059,molecular_function,NF-kappaB binding;GO:0042060,biological_process,wound healing;GO:0008654,biological_process,phospholipid biosynthetic process;GO:0015908,biological_process,fatty acid transport;GO:0010628,biological_process,positive regulation of gene expression;GO:0019395,biological_process,fatty acid oxidation;GO:0014068,biological_process,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0032966,biological_process,negative regulation of collagen biosynthetic process;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006776,biological_process,vitamin A metabolic process;GO:0043616,biological_process,keratinocyte proliferation;GO:0030308,biological_process,negative regulation of cell growth;GO:0043415,biological_process,positive regulation of skeletal muscle tissue regeneration;GO:0097755,biological_process,positive regulation of blood vessel diameter;GO:0050680,biological_process,negative regulation of epithelial cell proliferation;GO:0071456,biological_process,cellular response to hypoxia;GO:0045598,biological_process,regulation of fat cell differentiation;GO:0008270,molecular_function,zinc ion binding;GO:0007507,biological_process,heart development;GO:0030154,biological_process,cell differentiation;GO:0004879,molecular_function,nuclear receptor activity;GO:0005504,molecular_function,fatty acid binding;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:2000288,biological_process,positive regulation of myoblast proliferation;GO:0008283,biological_process,cell proliferation;GO:0032024,biological_process,positive regulation of insulin secretion;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0003713,molecular_function,transcription coactivator activity;GO:0046872,molecular_function,metal ion binding;GO:0001227,molecular_function,transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0014842,biological_process,regulation of skeletal muscle satellite cell proliferation;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0001890,biological_process,placenta development;GO:0060612,biological_process,adipose tissue development;GO:0006355,biological_process,regulation of transcription, DNA-templated","K04504,ko05221,Acute myeloid leukemia;K04504,ko04310,Wnt signaling pathway;K04504,ko03320,PPAR signaling pathway;K04504,ko05200,Pathways in cancer"]
["IFI16",2.780983946,1.361653909,1.026732014,3.549848821,0.017095036,0.030632492,"ENSG00000163565","A0A140TAW5,Gamma-interferon-inducible protein 16","NP_001125164.1,gamma-interferon-inducible protein 16","PF02760,HIN-200/IF120x domain;PF02758,PAAD/DAPIN/Pyrin domain","IPR004020,DAPIN domain;IPR004021,HIN-200/IF120x","-","GO:0051607,biological_process,defense response to virus;GO:0097202,biological_process,activation of cysteine-type endopeptidase activity;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0002218,biological_process,activation of innate immune response;GO:0008134,molecular_function,transcription factor binding;GO:0016607,cellular_component,nuclear speck;GO:0005634,cellular_component,nucleus;GO:0010506,biological_process,regulation of autophagy;GO:0071479,biological_process,cellular response to ionizing radiation;GO:0030224,biological_process,monocyte differentiation;GO:0032731,biological_process,positive regulation of interleukin-1 beta production;GO:0005829,cellular_component,cytosol;GO:0001047,molecular_function,core promoter binding;GO:0042771,biological_process,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042149,biological_process,cellular response to glucose starvation;GO:0040029,biological_process,regulation of gene expression, epigenetic;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0043392,biological_process,negative regulation of DNA binding;GO:0045071,biological_process,negative regulation of viral genome replication;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0072332,biological_process,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0005654,cellular_component,nucleoplasm;GO:2000117,biological_process,negative regulation of cysteine-type endopeptidase activity;GO:0005730,cellular_component,nucleolus;GO:0045824,biological_process,negative regulation of innate immune response;GO:0003690,molecular_function,double-stranded DNA binding","-"]
["CCDC8",4.582175228,2.243571675,1.026732014,3.549848821,0.017095036,0.030632492,"ENSG00000169515","G8IFA7,p90","NP_114429.2,coiled-coil domain-containing protein 8","PF14893,PNMA","IPR026523,Paraneoplastic antigen Ma;IPR026526,Coiled-coil domain-containing protein 8","ENOG410Y3DP,-;ENOG410J8V3,-","-","-"]
["RP4-583P15.15",4.615212855,2.259747897,1.026732014,3.549848821,0.017095036,0.030632492,"ENSG00000273154","V9GY48,Uncharacterized protein","-","PF01585,-patch domain","IPR000467,G-patch domain;IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type","ENOG410Z4ZI,-;KOG2185,Predicted RNA-processing protein, contains G-patch domain","GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0046872,molecular_function,metal ion binding;GO:0005634,cellular_component,nucleus","-"]
["TSPAN6",12.51443765,6.141431716,1.026039392,5.430289655,0.000198737,0.000564567,"ENSG00000000003","H2QYV9,Tetraspanin","XP_016798798.1,-;XP_529071.3,-","PF00335,Tetraspanin family","IPR018503,Tetraspanin, conserved site;IPR018499,Tetraspanin/Peripherin;IPR008952,Tetraspanin, EC2 domain superfamily;IPR000301,Tetraspanin","KOG3882,Tetraspanin family integral membrane protein;ENOG4111IRY,-","GO:0039532,biological_process,negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway;GO:0007166,biological_process,cell surface receptor signaling pathway;GO:1901223,biological_process,negative regulation of NIK/NF-kappaB signaling;GO:0016020,cellular_component,membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["NR6A1",2.533263762,1.241846297,1.025657508,3.828490022,0.00782065,0.015335411,"ENSG00000148200","F1D8S0,Germ cell nuclear factor variant 1","NP_201591.2,nuclear receptor subfamily 6 group A member 1 isoform 1","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR001628,Zinc finger, nuclear hormone receptor-type;IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR013088,Zinc finger, NHR/GATA-type","KOG3575,FOG: Hormone receptors;ENOG410XRZC,-","GO:0007276,biological_process,gamete generation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0046872,molecular_function,metal ion binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway","-"]
["NIN",6.09139158,2.993344342,1.024397358,5.976877756,{"v":5.63E-5,"d":"5.63E-05"},0.000180739,"ENSG00000100503","K7ASR3,Ninein","-","-","IPR002048,EF-hand domain;IPR029664,Ninein;IPR011992,EF-hand domain pair","ENOG410IK59,-;ENOG410Z1RR,-","GO:0005813,cellular_component,centrosome;GO:0034454,biological_process,microtubule anchoring at centrosome;GO:0005509,molecular_function,calcium ion binding","-"]
["PHF5A",19.99664381,9.816637626,1.024376204,4.262183568,0.003043045,0.006555785,"ENSG00000100410","B4F759,PHD finger protein 5A","NP_620243.1,-","PF03660,PHF5-like protein","IPR005345,PHF5-like","KOG1705,Uncharacterized conserved protein, contains CXXC motifs;ENOG4111JIM,-","GO:0005689,cellular_component,U12-type spliceosomal complex;GO:0005686,cellular_component,U2 snRNP;GO:0016607,cellular_component,nuclear speck;GO:0016363,cellular_component,nuclear matrix;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0005654,cellular_component,nucleoplasm","K12834,ko03040,Spliceosome"]
["NUDT9",7.756235901,3.807646818,1.024376204,4.262183568,0.003043045,0.006555785,"ENSG00000170502","A0A024RDI6,Nudix","NP_076952.1,ADP-ribose pyrophosphatase, mitochondrial isoform a precursor","PF00293,NUDIX domain","IPR015797,NUDIX hydrolase-like domain superfamily;IPR000086,NUDIX hydrolase domain","ENOG410XPYY,-;KOG4195,Transient receptor potential-related channel 7","GO:0046032,biological_process,ADP catabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0005739,cellular_component,mitochondrion;GO:0043262,molecular_function,adenosine-diphosphatase activity;GO:0046709,biological_process,IDP catabolic process","K13988,ko00230,Purine metabolism"]
["HYOU1",12.56125281,6.175097418,1.023915471,6.188073713,{"v":3.64e-05,"d":"3.64E-05"},1.2205E-4,"ENSG00000149428","G3QYC5,Hypoxia up-regulated 1","XP_018891676.1,hypoxia up-regulated protein 1 isoform X4;XP_018891677.1,-","PF00012,Hsp70 protein","IPR018181,Heat shock protein 70, conserved site;IPR013126,Heat shock protein 70 family;IPR029047,Heat shock protein 70kD, peptide-binding domain superfamily;IPR029048,Heat shock protein 70kD, C-terminal domain superfamily","-","GO:0002931,biological_process,response to ischemia;GO:1903382,biological_process,negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0006888,biological_process,ER to Golgi vesicle-mediated transport;GO:1903298,biological_process,negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:0034663,cellular_component,endoplasmic reticulum chaperone complex;GO:0071456,biological_process,cellular response to hypoxia;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["INCENP",53.0343584,26.07828894,1.023861772,7.473968918,{"v":5.13E-6,"d":"5.13E-06"},{"v":2.08e-05,"d":"2.08E-05"},"ENSG00000149503","K7CHZ7,Inner centromere protein antigens 135/155kDa","-","PF12178,Chromosome passenger complex (CPC) protein INCENP N terminal;PF03941,Inner centromere protein, ARK binding region","IPR022006,Chromosome passenger complex (CPC) protein INCENP N-terminal;IPR005635,Inner centromere protein, ARK-binding domain","ENOG410XRQ9,-;KOG4456,Inner centromere protein (INCENP), C-terminal domain","-","-"]
["NAA35",8.608827019,4.229657215,1.023638404,4.594808317,0.001107662,2.65183E-3,"ENSG00000135040","H2QXE6,N","-","PF04112,Mak10 subunit, NatC N(alpha)-terminal acetyltransferase","IPR007244,NatC N(alpha)-terminal acetyltransferase, Mak10 subunit","KOG2343,Glucose-repressible protein and related proteins;ENOG410XS3T,-","GO:0031417,cellular_component,NatC complex;GO:0006474,biological_process,N-terminal protein amino acid acetylation;GO:0004596,molecular_function,peptide alpha-N-acetyltransferase activity","-"]
["MMAB",5.511793515,2.708823393,1.023375612,4.736101791,0.000810289,0.001996016,"ENSG00000139428","B2R6J3,cDNA, FLJ92974, highly similar to Homo sapiens methylmalonic aciduria","-","PF01923,Cobalamin adenosyltransferase","IPR029499,ATP:cob(I)alamin adenosyltransferase, PduO-type;IPR036451,Cobalamin adenosyltransferase-like superfamily;IPR016030,Cobalamin adenosyltransferase-like","ENOG410IEUE,-;COG2096,Uncharacterized conserved protein","GO:0005515,molecular_function,protein binding","-"]
["CHP1",9.618638796,4.728307942,1.023158803,4.864748399,0.000701962,1.753599E-3,"ENSG00000187446","A0A1D5R6I4,Calcineurin like EF-hand protein 1","NP_001253300.1,-","-","IPR002048,EF-hand domain;IPR011992,EF-hand domain pair","KOG0034,Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein;COG5126,Ca2+-binding protein (EF-Hand superfamily)","GO:0005509,molecular_function,calcium ion binding","-"]
["CCDC73",1.356915116,0.665728904,1.022522396,3.118709008,0.026608564,0.045046456,"ENSG00000186714","H2Q3D1,Uncharacterized protein","XP_009458464.2,coiled-coil domain-containing protein 73","PF15818,Coiled-coil domain-containing protein 73 family","IPR031650,Coiled-coil domain-containing protein 73","ENOG410IKRA,-;ENOG4112DB3,-","-","-"]
["LINC00294",3.232216134,1.585787998,1.022522396,3.118709008,0.026608564,0.045046456,"ENSG00000280798","K7BHU7,Phosphatidylinositol glycan anchor biosynthesis, class C","-","PF06432,Phosphatidylinositol N-acetylglucosaminyltransferase","IPR009450,Phosphatidylinositol N-acetylglucosaminyltransferase subunit C","ENOG41112YY,-;KOG3059,N-acetylglucosaminyltransferase complex, subunit PIG-C/GPI2, required for phosphatidylinositol biosynthesis","GO:0017176,molecular_function,phosphatidylinositol N-acetylglucosaminyltransferase activity;GO:0006506,biological_process,GPI anchor biosynthetic process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ASPSCR1",0.883335252,0.433381427,1.022522396,3.118709008,0.026608564,0.045046456,"ENSG00000169696","H2QE39,Uncharacterized protein","-","PF11470,TUG ubiquitin-like domain;PF00789,UBX domain","IPR029071,Ubiquitin-like domain superfamily;IPR021569,TUG ubiquitin-like domain;IPR001012,UBX domain","KOG2699,Predicted ubiquitin regulatory protein;ENOG410XQQK,-","GO:0042593,biological_process,glucose homeostasis;GO:0009898,cellular_component,cytoplasmic side of plasma membrane;GO:0046324,biological_process,regulation of glucose import;GO:0031401,biological_process,positive regulation of protein modification process;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0006886,biological_process,intracellular protein transport;GO:0005886,cellular_component,plasma membrane;GO:0019898,cellular_component,extrinsic component of membrane;GO:0005829,cellular_component,cytosol;GO:0012506,cellular_component,vesicle membrane;GO:0005654,cellular_component,nucleoplasm","-"]
["INPP5D",1.23093037,0.603918341,1.022522396,3.118709008,0.026608564,0.045046456,"ENSG00000168918","U3DUB1,Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform b","-","PF03372,ndonuclease/Exonuclease/phosphatase family;PF00017,SH2 domain","IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR000300,Inositol polyphosphate-related phosphatase;IPR005135,Endonuclease/exonuclease/phosphatase;IPR036860,SH2 domain superfamily;IPR000980,SH2 domain","COG5411,Phosphatidylinositol 5-phosphate phosphatase;KOG0565,Inositol polyphosphate 5-phosphatase and related proteins","GO:0046856,biological_process,phosphatidylinositol dephosphorylation;GO:0016787,molecular_function,hydrolase activity","-"]
["GTF2H3",3.506043186,1.721955042,1.022137605,3.483778269,0.013627988,0.02521734,"ENSG00000111358","H9ENW1,General transcription factor IIH subunit 3","XP_014965115.1,-","PF03850,Transcription factor Tfb4","IPR004600,TFIIH subunit Tfb4/GTF2H3;IPR036465,von Willebrand factor A-like domain superfamily","KOG2487,RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4;COG5242,RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008353,molecular_function,RNA polymerase II carboxy-terminal domain kinase activity;GO:0008094,molecular_function,DNA-dependent ATPase activity;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0005675,cellular_component,holo TFIIH complex;GO:0047485,molecular_function,protein N-terminus binding;GO:0000439,cellular_component,core TFIIH complex;GO:0006289,biological_process,nucleotide-excision repair;GO:0004672,molecular_function,protein kinase activity;GO:0097550,cellular_component,transcriptional preinitiation complex;GO:0000438,cellular_component,core TFIIH complex portion of holo TFIIH complex;GO:0006468,biological_process,protein phosphorylation;GO:0005634,cellular_component,nucleus;GO:0005669,cellular_component,transcription factor TFIID complex;GO:0005654,cellular_component,nucleoplasm","K03143,ko03420,Nucleotide excision repair;K03143,ko03022,Basal transcription factors;K03143,ko05203,Viral carcinogenesis"]
["FAM13A",1.060170153,0.520691059,1.022137605,3.483778269,0.013627988,0.02521734,"ENSG00000138640","H2QPW1,Family with sequence similarity 13, member A","XP_009446291.1,protein FAM13A isoform X1","PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain","ENOG410XRR2,-;KOG4270,GTPase-activator protein","GO:0007165,biological_process,signal transduction","-"]
["AC240274.1",3.099590392,1.522330165,1.022137605,3.483778269,0.013627988,0.02521734,"ENSG00000271254","A0A087WVG8,Neuroblastoma breakpoint family member 11","-","PF06758,Repeat of unknown function (DUF1220)","IPR010630,Neuroblastoma breakpoint family (NBPF) domain","ENOG410KG3F,-;ENOG4110SQ7,-","-","-"]
["ANXA1",167.6434264,82.54446358,1.022085605,9.158374744,{"v":1.4e-06,"d":"1.40E-06"},{"v":6.44e-06,"d":"6.44E-06"},"ENSG00000135046","H2R6M9,Annexin","-","PF00191,Annexin","IPR037104,Annexin superfamily;IPR018502,Annexin repeat;IPR001464,Annexin;IPR018252,Annexin repeat, conserved site;IPR002388,Annexin A1","ENOG410XPUN,-;KOG0819,Annexin","GO:0031232,cellular_component,extrinsic component of external side of plasma membrane;GO:0090050,biological_process,positive regulation of cell migration involved in sprouting angiogenesis;GO:0032743,biological_process,positive regulation of interleukin-2 production;GO:0042127,biological_process,regulation of cell proliferation;GO:0098609,biological_process,cell-cell adhesion;GO:0097350,biological_process,neutrophil clearance;GO:0019898,cellular_component,extrinsic component of membrane;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0070062,cellular_component,extracellular exosome;GO:0005509,molecular_function,calcium ion binding;GO:2000483,biological_process,negative regulation of interleukin-8 secretion;GO:0042102,biological_process,positive regulation of T cell proliferation;GO:0005198,molecular_function,structural molecule activity;GO:0045627,biological_process,positive regulation of T-helper 1 cell differentiation;GO:0005634,cellular_component,nucleus;GO:0005615,cellular_component,extracellular space;GO:0009986,cellular_component,cell surface;GO:0031340,biological_process,positive regulation of vesicle fusion;GO:0005737,cellular_component,cytoplasm;GO:0006909,biological_process,phagocytosis;GO:0090303,biological_process,positive regulation of wound healing;GO:0001533,cellular_component,cornified envelope;GO:0005544,molecular_function,calcium-dependent phospholipid binding;GO:0098641,molecular_function,cadherin binding involved in cell-cell adhesion;GO:0006954,biological_process,inflammatory response;GO:0048306,molecular_function,calcium-dependent protein binding;GO:0005829,cellular_component,cytosol;GO:0002685,biological_process,regulation of leukocyte migration;GO:0046632,biological_process,alpha-beta T cell differentiation;GO:0046883,biological_process,regulation of hormone secretion;GO:0033031,biological_process,positive regulation of neutrophil apoptotic process;GO:0042383,cellular_component,sarcolemma;GO:0016328,cellular_component,lateral plasma membrane;GO:0005768,cellular_component,endosome;GO:0002548,biological_process,monocyte chemotaxis;GO:0071621,biological_process,granulocyte chemotaxis;GO:0014839,biological_process,myoblast migration involved in skeletal muscle regeneration;GO:0043086,biological_process,negative regulation of catalytic activity;GO:0045629,biological_process,negative regulation of T-helper 2 cell differentiation;GO:0071385,biological_process,cellular response to glucocorticoid stimulus;GO:0019834,molecular_function,phospholipase A2 inhibitor activity;GO:1900087,biological_process,positive regulation of G1/S transition of mitotic cell cycle;GO:0001780,biological_process,neutrophil homeostasis;GO:0008360,biological_process,regulation of cell shape;GO:0007165,biological_process,signal transduction;GO:0005654,cellular_component,nucleoplasm;GO:0035924,biological_process,cellular response to vascular endothelial growth factor stimulus;GO:0050727,biological_process,regulation of inflammatory response;GO:0005884,cellular_component,actin filament;GO:0016324,cellular_component,apical plasma membrane;GO:0007187,biological_process,G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0030216,biological_process,keratinocyte differentiation;GO:0031514,cellular_component,motile cilium;GO:0032652,biological_process,regulation of interleukin-1 production;GO:0050482,biological_process,arachidonic acid secretion;GO:0005913,cellular_component,cell-cell adherens junction;GO:0005886,cellular_component,plasma membrane;GO:0004859,molecular_function,phospholipase inhibitor activity;GO:0045920,biological_process,negative regulation of exocytosis;GO:0030674,molecular_function,protein binding, bridging;GO:0018149,biological_process,peptide cross-linking","-"]
["ZFYVE19",4.322877723,2.125458631,1.021739035,4.015782934,0.00460209,0.009542893,"ENSG00000166140","H2Q970,Zinc finger FYVE-type containing 19","-","PF01363,YVE zinc finger","IPR017455,Zinc finger, FYVE-related;IPR000306,FYVE zinc finger;IPR011011,Zinc finger, FYVE/PHD-type;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410XNRF,-;KOG1818,Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains","GO:0030496,cellular_component,midbody;GO:0032466,biological_process,negative regulation of cytokinesis;GO:0046872,molecular_function,metal ion binding;GO:0044878,biological_process,mitotic cytokinesis checkpoint;GO:0032266,molecular_function,phosphatidylinositol-3-phosphate binding;GO:0009838,biological_process,abscission;GO:0005813,cellular_component,centrosome;GO:0032154,cellular_component,cleavage furrow","-"]
["NUS1",4.418099367,2.172276903,1.021739035,4.015782934,0.00460209,0.009542893,"ENSG00000153989","B3KWI6,cDNA FLJ43129 fis, clone CTONG3005648","-","PF01255,Putative undecaprenyl diphosphate synthase","IPR001441,Decaprenyl diphosphate synthase-like;IPR036424,Decaprenyl diphosphate synthase-like superfamily","KOG2818,Predicted undecaprenyl diphosphate synthase;COG0020,Undecaprenyl pyrophosphate synthase","GO:0016765,molecular_function,transferase activity, transferring alkyl or aryl (other than methyl) groups","-"]
["DCAF1",5.443311843,2.679099566,1.02136411,4.83870362,0.000735631,1.829188E-3,"ENSG00000145041","K7B9N6,Vpr","XP_009443831.1,-;XP_001169544.2,-;XP_016796672.1,-;XP_016796673.1,-;XP_016796670.1,-;XP_009443830.1,-;XP_016796671.1,-","-","IPR016024,Armadillo-type fold;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR036322,WD40-repeat-containing domain superfamily;IPR006594,LIS1 homology motif;IPR033270,VPRBP/DCAF1 family","KOG1832,HIV-1 Vpr-binding protein;ENOG410XR8C,-","GO:0030331,molecular_function,estrogen receptor binding;GO:0008180,cellular_component,COP9 signalosome;GO:0016567,biological_process,protein ubiquitination;GO:0030183,biological_process,B cell differentiation;GO:0080008,cellular_component,Cul4-RING E3 ubiquitin ligase complex;GO:0033151,biological_process,V(D)J recombination;GO:0001650,cellular_component,fibrillar center;GO:1990245,biological_process,histone H2A-T120 phosphorylation;GO:1990244,molecular_function,histone kinase activity (H2A-T120 specific);GO:0035212,biological_process,cell competition in a multicellular organism;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus","-"]
["CCDC97",11.49702352,5.659719282,1.021293532,5.069746472,0.000437539,1.143626E-3,"ENSG00000142039","A0A024R0L2,Uncharacterized protein","-","PF09747,Coiled-coil domain containing protein (DUF2052)","IPR018613,Protein of unknown function DUF2052, coiled-coil","ENOG4111QQ2,-;KOG3044,Uncharacterized conserved protein","-","-"]
["CHMP2B",14.14363389,6.962584474,1.021293532,5.069746472,0.000437539,1.143626E-3,"ENSG00000083937","K7C9W0,Chromatin modifying protein 2B","XP_009444174.2,-","PF03357,Snf7","IPR005024,Snf7 family","KOG3231,Predicted assembly/vacuolar sorting protein;ENOG4111QA0,-","GO:0007080,biological_process,mitotic metaphase plate congression;GO:0005886,cellular_component,plasma membrane;GO:0005770,cellular_component,late endosome;GO:0010824,biological_process,regulation of centrosome duplication;GO:0005737,cellular_component,cytoplasm;GO:1901673,biological_process,regulation of mitotic spindle assembly;GO:0070050,biological_process,neuron cellular homeostasis;GO:0005768,cellular_component,endosome;GO:0007032,biological_process,endosome organization;GO:1902188,biological_process,positive regulation of viral release from host cell;GO:0019904,molecular_function,protein domain specific binding;GO:0005622,cellular_component,intracellular;GO:0005764,cellular_component,lysosome;GO:0050890,biological_process,cognition;GO:0005829,cellular_component,cytosol;GO:0000920,biological_process,cell separation after cytokinesis;GO:0006997,biological_process,nucleus organization;GO:0007034,biological_process,vacuolar transport;GO:0039702,biological_process,viral budding via host ESCRT complex;GO:0000815,cellular_component,ESCRT III complex;GO:0045296,molecular_function,cadherin binding","K12192,ko04144,Endocytosis"]
["KIDINS220",5.464026083,2.690613021,1.021184866,5.523683834,0.000162825,0.000470522,"ENSG00000134313","G3R2Z2,Kinase D interacting substrate 220","XP_004028855.1,kinase D-interacting substrate of 220 kDa isoform X4","PF12796,Ankyrin repeats (3 copies);PF13857,Ankyrin repeats (many copies);PF07693,KAP family P-loop domain","IPR011646,KAP family P-loop domain;IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR036770,Ankyrin repeat-containing domain superfamily","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ABCC5",6.454864538,3.178974076,1.02113314,5.805692542,{"v":8.51e-05,"d":"8.51E-05"},0.000261114,"ENSG00000114770","K7AN90,ATP-binding cassette, sub-family C","XP_016797875.1,-;XP_016797874.1,-;XP_016797873.1,multidrug resistance-associated protein 5 isoform X1","PF00005,ABC transporter;PF00664,ABC transporter transmembrane region","IPR030238,Multidrug resistance-associated protein 5;IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR011527,ABC transporter type 1, transmembrane domain;IPR036640,ABC transporter type 1, transmembrane domain superfamily;IPR003593,AAA+ ATPase domain;IPR017871,ABC transporter, conserved site","-","GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0055085,biological_process,transmembrane transport;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016887,molecular_function,ATPase activity;GO:0016020,cellular_component,membrane;GO:0008514,molecular_function,organic anion transmembrane transporter activity;GO:0015711,biological_process,organic anion transport;GO:0016021,cellular_component,integral component of membrane","K05668,ko02010,ABC transporters"]
["TRIP12",17.47860526,8.611767534,1.020976569,7.367515367,{"v":6.07e-06,"d":"6.07E-06"},{"v":2.43e-05,"d":"2.43E-05"},"ENSG00000153827","G7N939,Uncharacterized protein","XP_014966778.1,-","PF00632,HECT-domain (ubiquitin-transferase)","IPR037197,WWE domain superfamily;IPR004170,WWE domain;IPR000569,HECT domain;IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold;IPR035983,HECT, E3 ligase catalytic domain","COG5021,Ubiquitin-protein ligase;KOG0168,Putative ubiquitin fusion degradation protein","GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0016740,molecular_function,transferase activity;GO:0016567,biological_process,protein ubiquitination","-"]
["PTPN1",23.03498563,11.35186397,1.020348758,6.135649683,{"v":3.96E-5,"d":"3.96E-05"},1.31638E-4,"ENSG00000196396","H2R283,Tyrosine-protein phosphatase non-receptor type","XP_525354.2,-","PF00102,Protein-tyrosine phosphatase","IPR016130,Protein-tyrosine phosphatase, active site;IPR000242,PTP type protein phosphatase;IPR029021,Protein-tyrosine phosphatase-like;IPR012265,Protein-tyrosine phosphatase, non-receptor type-1/2;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR000387,Tyrosine specific protein phosphatases domain","KOG0789,Protein tyrosine phosphatase;COG5599,Protein tyrosine phosphatase","GO:0019901,molecular_function,protein kinase binding;GO:1903898,biological_process,negative regulation of PERK-mediated unfolded protein response;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005886,cellular_component,plasma membrane;GO:0005769,cellular_component,early endosome;GO:2000646,biological_process,positive regulation of receptor catabolic process;GO:0016311,biological_process,dephosphorylation;GO:0030971,molecular_function,receptor tyrosine kinase binding;GO:0036498,biological_process,IRE1-mediated unfolded protein response;GO:0097443,cellular_component,sorting endosome;GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0005737,cellular_component,cytoplasm;GO:0098554,cellular_component,cytoplasmic side of endoplasmic reticulum membrane;GO:0046875,molecular_function,ephrin receptor binding;GO:0006470,biological_process,protein dephosphorylation;GO:0061098,biological_process,positive regulation of protein tyrosine kinase activity;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:1990264,biological_process,peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;GO:0016021,cellular_component,integral component of membrane;GO:0030100,biological_process,regulation of endocytosis;GO:0034976,biological_process,response to endoplasmic reticulum stress;GO:0008286,biological_process,insulin receptor signaling pathway;GO:0035791,biological_process,platelet-derived growth factor receptor-beta signaling pathway;GO:0016020,cellular_component,membrane;GO:1902236,biological_process,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0008270,molecular_function,zinc ion binding;GO:0019899,molecular_function,enzyme binding;GO:0007257,biological_process,activation of JUN kinase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0033157,biological_process,regulation of intracellular protein transport;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0045296,molecular_function,cadherin binding;GO:0030948,biological_process,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0009966,biological_process,regulation of signal transduction;GO:0043407,biological_process,negative regulation of MAP kinase activity;GO:1902202,biological_process,regulation of hepatocyte growth factor receptor signaling pathway;GO:0016791,molecular_function,phosphatase activity","-"]
["MLST8",13.84222915,6.821584561,1.020044171,5.507261986,0.000154681,0.000450384,"ENSG00000167965","A0A0A0MR05,Target of rapamycin complex subunit LST8","-","PF00400,WD domain, G-beta repeat","IPR019775,WD40 repeat, conserved site;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR001680,WD40 repeat;IPR037588,Target of rapamycin complex subunit LST8","ENOG410XPVD,-;KOG0315,G-protein beta subunit-like protein (contains WD40 repeats)","GO:0031931,cellular_component,TORC1 complex;GO:0031932,cellular_component,TORC2 complex;GO:0031929,biological_process,TOR signaling;GO:0032008,biological_process,positive regulation of TOR signaling","-"]
["UNC119B",8.319104224,4.099735116,1.019716366,5.04718844,0.000518531,1.339441E-3,"ENSG00000175970","I0FGY1,Protein unc-119 homolog B","NP_001253411.1,-","PF05351,MP-PDE, delta subunit","IPR008015,GMP phosphodiesterase, delta subunit;IPR037036,GMP phosphodiesterase, delta subunit superfamily;IPR014756,Immunoglobulin E-set","-","-","-"]
["RTCA",13.13576042,6.473429932,1.019618068,4.934475246,0.000671389,0.001684805,"ENSG00000137996","K7B7Q2,RNA terminal phosphate cyclase domain 1","-","PF01137,RNA 3'-terminal phosphate cyclase;PF05189,RNA 3'-terminal phosphate cyclase (RTC), insert domain","IPR000228,RNA 3'-terminal phosphate cyclase;IPR013791,RNA 3'-terminal phosphate cyclase, insert domain;IPR036553,RNA 3'-terminal phosphate cyclase, insert domain superfamily;IPR017770,RNA 3'-terminal phosphate cyclase type 1;IPR023797,RNA 3'-terminal phosphate cyclase domain;IPR020719,RNA 3'-terminal phosphate cyclase-like, conserved site;IPR037136,RNA 3'-terminal phosphate cyclase domain superfamily;IPR013792,RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta","KOG3980,RNA 3'-terminal phosphate cyclase;COG0430,RNA 3'-terminal phosphate cyclase","GO:0003824,molecular_function,catalytic activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0006396,biological_process,RNA processing;GO:0003963,molecular_function,RNA-3'-phosphate cyclase activity","-"]
["CEP89",4.320730468,2.129297813,1.019618068,4.934475246,0.000671389,0.001684805,"ENSG00000121289","K7CAM3,Coiled-coil domain containing 123","-","-","IPR033545,Centrosomal protein of 89kDa","ENOG410ZNEI,-;ENOG410IGSG,-","GO:0060271,biological_process,cilium assembly;GO:0007005,biological_process,mitochondrion organization;GO:0007268,biological_process,chemical synaptic transmission;GO:0005814,cellular_component,centriole","-"]
["DARS",23.01245553,11.34659165,1.019603533,6.124932043,{"v":4.35E-5,"d":"4.35E-05"},0.000143405,"ENSG00000115866","A0A140VJW5,Testicular tissue protein Li 192","NP_001340.2,aspartate--tRNA ligase, cytoplasmic isoform 1","PF00152,tRNA synthetases class II (D, K and N);PF01336,OB-fold nucleic acid binding domain","IPR004364,Aminoacyl-tRNA synthetase, class II (D/K/N);IPR004365,OB-fold nucleic acid binding domain, AA-tRNA synthetase-type;IPR006195,Aminoacyl-tRNA synthetase, class II;IPR004523,Aspartate-tRNA synthetase, type 2;IPR002312,Aspartyl/Asparaginyl-tRNA synthetase, class IIb;IPR012340,Nucleic acid-binding, OB-fold","-","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0004815,molecular_function,aspartate-tRNA ligase activity;GO:0006422,biological_process,aspartyl-tRNA aminoacylation;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0017101,cellular_component,aminoacyl-tRNA synthetase multienzyme complex","K01876,ko00970,Aminoacyl-tRNA biosynthesis"]
["SYTL1",5.953513671,2.933949186,1.019362583,4.678509932,1.212124E-3,0.002877097,"ENSG00000142765","A8KAH3,cDNA FLJ75170, highly similar to Homo sapiens synaptotagmin-like 1, mRNA","-","PF00168,C2 domain","IPR000008,C2 domain;IPR028378,Synaptotagmin-like protein 1;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR010911,Rab-binding domain;IPR035892,C2 domain superfamily","ENOG410IT3I,-;ENOG41107B6,-","GO:0017137,molecular_function,Rab GTPase binding;GO:0006886,biological_process,intracellular protein transport;GO:0005622,cellular_component,intracellular;GO:0006887,biological_process,exocytosis","-"]
["GPRC5A",14.01127398,6.910437586,1.019307862,6.477765479,{"v":2.28e-05,"d":"2.28E-05"},{"v":8.02e-05,"d":"8.02E-05"},"ENSG00000013588","A8K556,cDNA FLJ78217","-","PF00003,7 transmembrane sweet-taste receptor of 3 GCPR","IPR017978,GPCR family 3, C-terminal","ENOG410IIGU,-;ENOG410YD51,-","GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0007186,biological_process,G-protein coupled receptor signaling pathway","-"]
["SNX14",3.743214113,1.844692161,1.018979607,4.36689557,0.00248181,0.005483973,"ENSG00000135317","H2QTD0,Sorting nexin 14","XP_009449879.1,-","PF02194,PXA domain;PF00615,Regulator of G protein signaling domain;PF08628,Sorting nexin C terminal;PF00787,PX domain","IPR013937,Sorting nexin, C-terminal;IPR037892,SNX14, RGS domain;IPR036305,RGS domain superfamily;IPR036871,PX domain superfamily;IPR037436,Sorting nexin-14, PX domain;IPR003114,Phox-associated domain;IPR001683,Phox homologous domain;IPR016137,RGS domain","ENOG410XS0F,-;ENOG410IMHX,-","GO:0005770,cellular_component,late endosome;GO:0005764,cellular_component,lysosome;GO:0080025,molecular_function,phosphatidylinositol-3,5-bisphosphate binding;GO:0035091,molecular_function,phosphatidylinositol binding;GO:0016020,cellular_component,membrane;GO:0097352,biological_process,autophagosome maturation;GO:0016021,cellular_component,integral component of membrane","-"]
["COQ4",5.524623239,2.722587828,1.018979607,4.36689557,0.00248181,0.005483973,"ENSG00000167113","G3RFQ5,Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial","XP_004048728.1,ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform X1","PF05019,Coenzyme Q (ubiquinone) biosynthesis protein Coq4","IPR007715,Ubiquinone biosynthesis protein Coq4;IPR027540,Ubiquinone biosynthesis protein Coq4, eukaryotes","-","GO:0032991,cellular_component,protein-containing complex;GO:0006744,biological_process,ubiquinone biosynthetic process;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0031314,cellular_component,extrinsic component of mitochondrial inner membrane;GO:0016020,cellular_component,membrane;GO:0005739,cellular_component,mitochondrion","-"]
["BARX2",24.13529345,11.90689568,1.018770046,6.06148504,{"v":5.26e-05,"d":"5.26E-05"},0.000169733,"ENSG00000043039","H2Q542,Uncharacterized protein","XP_522247.2,-","PF00046,Homeobox domain","IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR020479,Homeobox domain, metazoa;IPR009057,Homeobox-like domain superfamily;IPR000047,Helix-turn-helix motif","ENOG411188D,-;KOG0488,Transcription factor BarH and related HOX domain proteins","GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001228,molecular_function,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0001502,biological_process,cartilage condensation;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0014902,biological_process,myotube differentiation;GO:0007399,biological_process,nervous system development;GO:0005829,cellular_component,cytosol;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0003682,molecular_function,chromatin binding;GO:0005654,cellular_component,nucleoplasm","-"]
["STX5",10.31063103,5.081178812,1.018706236,4.181426573,0.003774963,7.996642E-3,"ENSG00000162236","G1QW02,Syntaxin 5","XP_003274149.1,syntaxin-5 isoform X2","PF11416,Syntaxin-5 N-terminal, Sly1p-binding domain;PF05739,SNARE domain","IPR000727,Target SNARE coiled-coil homology domain;IPR010989,SNARE;IPR021538,Syntaxin-5, N-terminal, Sly1p-binding domain","ENOG410Y2MB,-;KOG0812,SNARE protein SED5/Syntaxin 5","GO:0016192,biological_process,vesicle-mediated transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["NOTCH2NL",3.09586407,1.525671791,1.018341978,3.968381909,0.006043547,0.01216039,"ENSG00000264343","A0A0B4J2B3,Neuroblastoma breakpoint family member 14","XP_006711766.1,notch homolog 2 N-terminal-like protein isoform X3;XP_006726418.1,-","PF00008,-like domain;PF07645,Calcium-binding EGF domain","IPR013032,EGF-like, conserved site;IPR001881,EGF-like calcium-binding domain;IPR018097,EGF-like calcium-binding, conserved site;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain","ENOG410XP6K,-;KOG1217,Fibrillins and related proteins containing Ca2+-binding EGF-like domains","GO:0005509,molecular_function,calcium ion binding","-"]
["SH3BP2",1.428024929,0.703744513,1.018341978,3.968381909,0.006043547,0.01216039,"ENSG00000087266","G3RE46,SH3 domain binding protein 2","-","PF00017,SH2 domain;PF00169,PH domain","IPR035847,SH3BP2, SH2 domain;IPR036860,SH2 domain superfamily;IPR035848,SH3 domain-binding protein 2;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR000980,SH2 domain","-","GO:0005070,molecular_function,SH3/SH2 adaptor activity;GO:0007165,biological_process,signal transduction;GO:0009967,biological_process,positive regulation of signal transduction","-"]
["RP11-500C11.3",18.33332004,9.03483764,1.018341978,3.968381909,0.006043547,0.01216039,"ENSG00000272269","U6DHZ9,NUP153 variant protein","-","-","IPR037625,Nuclear pore complex protein Nup153;IPR026054,Nuclear pore complex protein","-","GO:0005622,cellular_component,intracellular;GO:0006913,biological_process,nucleocytoplasmic transport;GO:0017056,molecular_function,structural constituent of nuclear pore","-"]
["E2F7",2.637190254,1.299632893,1.017832474,3.718059492,0.010295498,0.019566066,"ENSG00000165891","H2Q6I9,E2F transcription factor 7","-","PF02319,2F/DP family winged-helix DNA-binding domain","IPR003316,E2F/DP family, winged-helix DNA-binding domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR015633,E2F Family;IPR036388,Winged helix-like DNA-binding domain superfamily","KOG2578,Transcription factor E2F/dimerization partner (TDP)-like proteins;ENOG4111IGY,-","GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["PAF1",84.55290031,41.75621114,1.01763787,7.40378903,{"v":6.31e-06,"d":"6.31E-06"},{"v":2.51E-5,"d":"2.51E-05"},"ENSG00000006712","A0A091D867,RNA polymerase II-associated factor 1 like protein","XP_010612826.1,RNA polymerase II-associated factor 1 homolog","PF03985,Paf1","IPR007133,RNA polymerase II associated factor Paf1","-","GO:0016593,cellular_component,Cdc73/Paf1 complex;GO:0016570,biological_process,histone modification;GO:0006368,biological_process,transcription elongation from RNA polymerase II promoter","-"]
["CSDE1",106.7707611,52.73918379,1.017487015,8.850736132,{"v":1.8e-06,"d":"1.80E-06"},{"v":8.06e-06,"d":"8.06E-06"},"ENSG00000009307","F6VGQ4,Cold shock domain containing E1","XP_001111655.1,-","PF12901,SUZ-C motif;PF00313,'Cold-shock' DNA-binding domain","IPR024642,SUZ-C domain;IPR019844,Cold-shock conserved site;IPR002059,Cold-shock protein, DNA-binding;IPR011129,Cold shock domain;IPR012340,Nucleic acid-binding, OB-fold","ENOG410IF27,-;ENOG410ZH8Y,-","GO:0070937,cellular_component,CRD-mediated mRNA stability complex;GO:0005794,cellular_component,Golgi apparatus;GO:0003677,molecular_function,DNA binding;GO:0003676,molecular_function,nucleic acid binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005829,cellular_component,cytosol;GO:0005886,cellular_component,plasma membrane;GO:0070966,biological_process,nuclear-transcribed mRNA catabolic process, no-go decay","-"]
["MT-TA",471.4788392,232.6885335,1.017228943,4.648824074,0.001279878,0.003007857,"-","-","-","-","-","-","-","-"]
["SH3BP5-AS1",2.319513019,1.143078476,1.017069211,3.41449973,0.018944149,0.033406551,"ENSG00000224660","H2PBE4,SH3 domain binding protein 5","XP_002814083.1,SH3 domain-binding protein 5","PF05276,SH3 domain-binding protein 5 (SH3BP5)","IPR007940,SH3-binding 5","ENOG410ZK48,-;KOG2008,BTK-associated SH3-domain binding protein SAB","GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0016604,cellular_component,nuclear body;GO:0005654,cellular_component,nucleoplasm;GO:0004860,molecular_function,protein kinase inhibitor activity;GO:0035556,biological_process,intracellular signal transduction","-"]
["SLC33A1",1.381299277,0.680717659,1.017069211,3.41449973,0.018944149,0.033406551,"ENSG00000169359","H2R208,Solute carrier family 33","XP_516831.2,acetyl-coenzyme A transporter 1 isoform X1;XP_009445001.1,-","PF13000,Acetyl-coenzyme A transporter 1","IPR036259,MFS transporter superfamily;IPR024371,Acetyl-coenzyme A transporter 1;IPR004752,AmpG-like permease/Acetyl-coenzyme A transporter 1","COG0477,Permeases of the major facilitator superfamily;KOG3574,Acetyl-CoA transporter","GO:0015295,molecular_function,solute:proton symporter activity;GO:0060395,biological_process,SMAD protein signal transduction;GO:1902600,biological_process,proton transmembrane transport;GO:0030509,biological_process,BMP signaling pathway;GO:0016020,cellular_component,membrane;GO:0015876,biological_process,acetyl-CoA transport;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0008521,molecular_function,acetyl-CoA transmembrane transporter activity","K03372,ko00604,Glycosphingolipid biosynthesis - ganglio series"]
["BLOC1S5",4.011393103,1.976853364,1.017069211,3.41449973,0.018944149,0.033406551,"ENSG00000188428","K7B843,Biogenesis of lysosome-related organelles complex 1 subunit 5","XP_001166060.1,-","PF14942,Organelle biogenesis, Muted-like protein","IPR017243,Biogenesis of lysosome-related organelles complex 1 subunit 5","ENOG410IEDX,-;ENOG4111SZ9,-","GO:0031083,cellular_component,BLOC-1 complex;GO:0030133,cellular_component,transport vesicle","-"]
["RP11-395G23.3",9.371224902,4.618230375,1.017069211,3.41449973,0.018944149,0.033406551,"-","-","-","-","-","-","-","-"]
["PCSK5",1.046656288,0.515802354,1.017069211,3.41449973,0.018944149,0.033406551,"ENSG00000099139","H2QXD2,Uncharacterized protein","XP_520079.2,proprotein convertase subtilisin/kexin type 5 isoform X2","PF00082,Subtilase family;PF14843,rowth factor receptor domain IV;PF16470,Peptidase S8 pro-domain;PF01483,Proprotein convertase P-domain","IPR032778,Growth factor receptor domain 4;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR006212,Furin-like repeat;IPR000209,Peptidase S8/S53 domain;IPR032815,Peptidase S8, pro-domain;IPR023828,Peptidase S8, subtilisin, Ser-active site;IPR008979,Galactose-binding-like domain superfamily;IPR015500,Peptidase S8, subtilisin-related;IPR023827,Peptidase S8, subtilisin,  Asp-active site;IPR038466,Peptidase S8, pro-domain superfamily;IPR000742,EGF-like domain;IPR011641,Tyrosine-protein kinase ephrin type A/B receptor-like;IPR022398,Peptidase S8, subtilisin, His-active site;IPR002884,P domain;IPR036852,Peptidase S8/S53 domain superfamily;IPR034182,Kexin/furin catalytic domain","KOG3525,Subtilisin-like proprotein convertase;COG4935,Regulatory P domain of the subtilisin-like proprotein convertases and other proteases;COG1404,Subtilisin-like serine proteases","GO:0030323,biological_process,respiratory tube development;GO:0043043,biological_process,peptide biosynthetic process;GO:0048566,biological_process,embryonic digestive tract development;GO:0005615,cellular_component,extracellular space;GO:0006508,biological_process,proteolysis;GO:0005794,cellular_component,Golgi apparatus;GO:0016787,molecular_function,hydrolase activity;GO:0042089,biological_process,cytokine biosynthetic process;GO:0007507,biological_process,heart development;GO:0016486,biological_process,peptide hormone processing;GO:0042277,molecular_function,peptide binding;GO:0003279,biological_process,cardiac septum development;GO:0008236,molecular_function,serine-type peptidase activity;GO:0004175,molecular_function,endopeptidase activity;GO:0001822,biological_process,kidney development;GO:0030141,cellular_component,secretory granule;GO:0016021,cellular_component,integral component of membrane;GO:0019058,biological_process,viral life cycle;GO:0048706,biological_process,embryonic skeletal system development;GO:0016485,biological_process,protein processing;GO:0006465,biological_process,signal peptide processing;GO:0035108,biological_process,limb morphogenesis;GO:0016020,cellular_component,membrane;GO:0060976,biological_process,coronary vasculature development;GO:0007368,biological_process,determination of left/right symmetry;GO:0007566,biological_process,embryo implantation;GO:0002001,biological_process,renin secretion into blood stream;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0008233,molecular_function,peptidase activity;GO:0009952,biological_process,anterior/posterior pattern specification","-"]
["SEH1L",6.139843466,3.032473445,1.016916777,5.611394526,0.000149804,0.000437609,"ENSG00000085415","G3R6H1,SEH1 like nucleoporin","XP_018869759.1,-","PF00400,WD domain, G-beta repeat","IPR017986,WD40-repeat-containing domain;IPR037597,Nucleoporin Seh1;IPR036322,WD40-repeat-containing domain superfamily;IPR037363,Sec13/Seh1 family;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR020472,G-protein beta WD-40 repeat;IPR001680,WD40 repeat","-","GO:0015031,biological_process,protein transport;GO:1904263,biological_process,positive regulation of TORC1 signaling;GO:0005198,molecular_function,structural molecule activity","-"]
["SDHAP1",7.719402277,3.811176367,1.016289317,4.329922408,0.002653054,0.005823185,"ENSG00000185485","G3QJN1,Uncharacterized protein","-","PF00890,AD binding domain;PF02910,umarate reductase flavoprotein C-term","IPR027477,Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily;IPR015939,Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal;IPR036188,FAD/NAD(P)-binding domain superfamily;IPR003953,FAD-dependent oxidoreductase 2, FAD binding domain;IPR037099,Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily","-","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity","-"]
["CDKN2C",3.005824624,1.48129948,1.01579975,3.028576229,0.038484828,0.062458283,"ENSG00000123080","F6QTJ3,Cyclin dependent kinase inhibitor 2C","NP_001253243.1,-;XP_014994666.1,-","PF00023,Ankyrin repeat","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily","KOG0504,FOG: Ankyrin repeat;COG0666,FOG: Ankyrin repeat","GO:0004861,molecular_function,cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0016301,molecular_function,kinase activity;GO:0019901,molecular_function,protein kinase binding;GO:0000079,biological_process,regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0030308,biological_process,negative regulation of cell growth;GO:0005737,cellular_component,cytoplasm;GO:0042326,biological_process,negative regulation of phosphorylation;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0045736,biological_process,negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0005634,cellular_component,nucleus;GO:0000082,biological_process,G1/S transition of mitotic cell cycle;GO:0007050,biological_process,cell cycle arrest;GO:0016310,biological_process,phosphorylation","K06622,ko04110,Cell cycle;K06622,ko05202,Transcriptional misregulation in cancer;K06622,ko05166,HTLV-I infection;K06622,ko01522,Endocrine resistance"]
["C11orf49",1.490112969,0.7343421,1.01579975,3.028576229,0.038484828,0.062458283,"ENSG00000149179","H9YW91,Uncharacterized protein","XP_014969683.1,-","-","-","ENOG410IIYX,-;ENOG4110Y2Q,-","-","-"]
["EIF3FP3",9.18354153,4.525738192,1.01579975,3.028576229,0.038484828,0.062458283,"ENSG00000233426","H2NE67,Eukaryotic translation initiation factor 3 subunit F","-","PF01398,JAB1/Mov34/MPN/PAD-1 ubiquitin protease;PF13012,Maintenance of mitochondrial structure and function","IPR037518,MPN domain;IPR024969,Rpn11/EIF3F, C-terminal;IPR000555,JAB1/MPN/MOV34 metalloenzyme domain;IPR027531,Eukaryotic translation initiation factor 3 subunit F","KOG2975,Translation initiation factor 3, subunit f (eIF-3f);COG1310,Predicted metal-dependent protease of the PAD1/JAB1 superfamily","GO:0003743,molecular_function,translation initiation factor activity;GO:0033290,cellular_component,eukaryotic 48S preinitiation complex;GO:0006412,biological_process,translation;GO:0006413,biological_process,translational initiation;GO:0005737,cellular_component,cytoplasm;GO:0005852,cellular_component,eukaryotic translation initiation factor 3 complex;GO:0016282,cellular_component,eukaryotic 43S preinitiation complex;GO:0002183,biological_process,cytoplasmic translational initiation;GO:0001732,biological_process,formation of cytoplasmic translation initiation complex","-"]
["RP1-169K13.3",16.03428634,7.901851569,1.01579975,3.028576229,0.038484828,0.062458283,"ENSG00000239500","Q8BKJ6,Uncharacterized protein","-","-","-","-","-","-"]
["PGAP1",1.767785738,0.873015997,1.015612493,4.139274635,0.004067432,0.008546439,"ENSG00000197121","G3QHD3,Post-GPI attachment to proteins 1","-","PF07819,PGAP1-like protein","IPR012908,GPI inositol-deacylase PGAP1-like;IPR029058,Alpha/Beta hydrolase fold","-","GO:0060322,biological_process,head development;GO:0021871,biological_process,forebrain regionalization;GO:0009948,biological_process,anterior/posterior axis specification;GO:0007605,biological_process,sensory perception of sound;GO:0009880,biological_process,embryonic pattern specification;GO:0016788,molecular_function,hydrolase activity, acting on ester bonds;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K05294,ko00563,Glycosylphosphatidylinositol(GPI)-anchor biosynthesis"]
["ANKRD13C",7.648335474,3.779360738,1.015559225,4.757610766,0.001136603,0.002716269,"ENSG00000118454","H2PZ81,Ankyrin repeat domain 13C","XP_001166457.1,ankyrin repeat domain-containing protein 13C isoform X1","PF12796,Ankyrin repeats (3 copies);PF11904,PCR-chaperone","IPR020683,Ankyrin repeat-containing domain;IPR002110,Ankyrin repeat;IPR036770,Ankyrin repeat-containing domain superfamily;IPR021832,Ankyrin repeat domain-containing protein 13","KOG0522,Ankyrin repeat protein;ENOG410XNMS,-","GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0005783,cellular_component,endoplasmic reticulum;GO:0005102,molecular_function,signaling receptor binding;GO:0010869,biological_process,regulation of receptor biosynthetic process;GO:2000209,biological_process,regulation of anoikis;GO:0006621,biological_process,protein retention in ER lumen","-"]
["VAMP3",17.29329319,8.547742046,1.01553403,5.188629267,0.00033558,9.02074E-4,"ENSG00000049245","H2N996,Vesicle associated membrane protein 3","XP_002811600.1,-","PF00957,Synaptobrevin","IPR016444,Synaptobrevin/Vesicle-associated membrane protein;IPR001388,Synaptobrevin","KOG0860,Synaptobrevin/VAMP-like protein;COG5143,Synaptobrevin/VAMP-like protein","GO:0042147,biological_process,retrograde transport, endosome to Golgi;GO:0001921,biological_process,positive regulation of receptor recycling;GO:0005886,cellular_component,plasma membrane;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0009986,cellular_component,cell surface;GO:0030136,cellular_component,clathrin-coated vesicle;GO:0005829,cellular_component,cytosol;GO:0030141,cellular_component,secretory granule;GO:0016021,cellular_component,integral component of membrane;GO:0031201,cellular_component,SNARE complex;GO:0045335,cellular_component,phagocytic vesicle;GO:0005622,cellular_component,intracellular;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:1903531,biological_process,negative regulation of secretion by cell;GO:0016020,cellular_component,membrane;GO:0034446,biological_process,substrate adhesion-dependent cell spreading;GO:0043001,biological_process,Golgi to plasma membrane protein transport;GO:0035493,biological_process,SNARE complex assembly;GO:0031410,cellular_component,cytoplasmic vesicle;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0055037,cellular_component,recycling endosome;GO:0016192,biological_process,vesicle-mediated transport;GO:0017156,biological_process,calcium ion regulated exocytosis","K13505,ko04130,SNARE interactions in vesicular transport;K13505,ko04145,Phagosome"]
["MAPK8IP3",4.317457187,2.134511504,1.015133599,5.086843564,0.000420613,1.108389E-3,"ENSG00000138834","A0A087WYG2,C-Jun-amino-terminal kinase-interacting protein 3","NP_001305781.1,C-Jun-amino-terminal kinase-interacting protein 3 isoform 3","PF09744,JNK_SAPK-associated protein-1;PF16471,JNK-interacting protein  leucine zipper II","IPR034744,RH2 domain;IPR032486,JNK-interacting protein, leucine zipper II;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR034743,RH1 domain;IPR019143,JNK/Rab-associated protein-1, N-terminal","ENOG410XQ19,-;KOG2077,JNK/SAPK-associated protein-1","GO:0031434,molecular_function,mitogen-activated protein kinase kinase binding;GO:0030673,cellular_component,axolemma;GO:0010468,biological_process,regulation of gene expression;GO:0005886,cellular_component,plasma membrane;GO:0030900,biological_process,forebrain development;GO:0043005,cellular_component,neuron projection;GO:0005737,cellular_component,cytoplasm;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0005078,molecular_function,MAP-kinase scaffold activity;GO:0031435,molecular_function,mitogen-activated protein kinase kinase kinase binding;GO:0008432,molecular_function,JUN kinase binding;GO:0030425,cellular_component,dendrite;GO:0005790,cellular_component,smooth endoplasmic reticulum;GO:0060425,biological_process,lung morphogenesis;GO:0008104,biological_process,protein localization;GO:0007411,biological_process,axon guidance;GO:0048286,biological_process,lung alveolus development;GO:0007254,biological_process,JNK cascade;GO:0000139,cellular_component,Golgi membrane;GO:0009791,biological_process,post-embryonic development;GO:0007585,biological_process,respiratory gaseous exchange;GO:0043507,biological_process,positive regulation of JUN kinase activity;GO:0007257,biological_process,activation of JUN kinase activity;GO:0019894,molecular_function,kinesin binding;GO:0001701,biological_process,in utero embryonic development;GO:0016192,biological_process,vesicle-mediated transport;GO:0046328,biological_process,regulation of JNK cascade;GO:0031175,biological_process,neuron projection development","-"]
["TMEM79",6.271363472,3.098219729,1.014702623,3.919357029,0.006573982,0.013103183,"ENSG00000163472","G3REA6,Transmembrane protein 79","XP_004027016.1,transmembrane protein 79;XP_018879983.1,-","-","IPR033582,Transmembrane protein 79","-","GO:0031069,biological_process,hair follicle morphogenesis;GO:0016021,cellular_component,integral component of membrane;GO:0061436,biological_process,establishment of skin barrier;GO:0042335,biological_process,cuticle development;GO:0045684,biological_process,positive regulation of epidermis development;GO:0045055,biological_process,regulated exocytosis;GO:0005737,cellular_component,cytoplasm;GO:0002070,biological_process,epithelial cell maturation;GO:0032588,cellular_component,trans-Golgi network membrane;GO:0016020,cellular_component,membrane;GO:0070268,biological_process,cornification;GO:0042802,molecular_function,identical protein binding;GO:0005765,cellular_component,lysosomal membrane","-"]
["RP4-530I15.9",4.193213815,2.071558733,1.014702623,3.919357029,0.006573982,0.013103183,"ENSG00000232043","A0A287A2K0,Tyrosine-protein phosphatase non-receptor type","-","-","IPR016130,Protein-tyrosine phosphatase, active site;IPR000242,PTP type protein phosphatase;IPR029021,Protein-tyrosine phosphatase-like;IPR012265,Protein-tyrosine phosphatase, non-receptor type-1/2;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR000387,Tyrosine specific protein phosphatases domain","-","GO:0016787,molecular_function,hydrolase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","-"]
["RNF168",29.84350433,14.76844778,1.0145812,6.908209162,{"v":1.25e-05,"d":"1.25E-05"},{"v":4.65e-05,"d":"4.65E-05"},"ENSG00000163961","H2QP09,E3 ubiquitin-protein ligase RNF168","-","PF14447,Prokaryotic RING finger family 4","IPR001841,Zinc finger, RING-type;IPR034725,E3 ubiquitin-protein ligase RNF168;IPR013083,Zinc finger, RING/FYVE/PHD-type","KOG4159,Predicted E3 ubiquitin ligase;COG2802,Uncharacterized protein, similar to the N-terminal domain of Lon protease","GO:0006325,biological_process,chromatin organization;GO:0006281,biological_process,DNA repair;GO:0016567,biological_process,protein ubiquitination;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0005634,cellular_component,nucleus;GO:0042393,molecular_function,histone binding;GO:0046872,molecular_function,metal ion binding;GO:0016740,molecular_function,transferase activity;GO:0006302,biological_process,double-strand break repair;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0010212,biological_process,response to ionizing radiation;GO:0043130,molecular_function,ubiquitin binding;GO:0033522,biological_process,histone H2A ubiquitination;GO:0045739,biological_process,positive regulation of DNA repair;GO:0000151,cellular_component,ubiquitin ligase complex;GO:0003682,molecular_function,chromatin binding","-"]
["SLC37A1",4.181863433,2.067732336,1.014317966,4.46449758,0.002259092,0.005054299,"ENSG00000160190","H2QL31,Solute carrier family 37","XP_001137933.1,glucose-6-phosphate exchanger SLC37A1 isoform X7","-","IPR036259,MFS transporter superfamily;IPR000849,Sugar phosphate transporter;IPR020846,Major facilitator superfamily domain;IPR011701,Major facilitator superfamily","ENOG410IP3Z,-;COG2271,Sugar phosphate permease","GO:0022857,molecular_function,transmembrane transporter activity;GO:0030176,cellular_component,integral component of endoplasmic reticulum membrane;GO:0015760,biological_process,glucose-6-phosphate transport;GO:0061513,molecular_function,glucose 6-phosphate:inorganic phosphate antiporter activity;GO:0035435,biological_process,phosphate ion transmembrane transport;GO:0055085,biological_process,transmembrane transport;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["CD2BP2",18.9439448,9.379181571,1.01349485,5.76165609,0.000109396,0.000328514,"ENSG00000169217","A0A024QZC1,CD2 antigen","NP_006101.1,CD2 antigen cytoplasmic tail-binding protein 2;NP_001230575.1,-","PF02213,YF domain","IPR035445,GYF-like domain superfamily;IPR003169,GYF domain","KOG2950,Uncharacterized protein involved in protein-protein interaction, contains polyproline-binding GYF domain;ENOG4111KF5,-","GO:0005829,cellular_component,cytosol;GO:0016607,cellular_component,nuclear speck;GO:0001650,cellular_component,fibrillar center","-"]
["RTN3",10.74146375,5.317742375,1.013491412,5.56454822,1.50206E-4,0.000438229,"ENSG00000133318","B7Z8W8,Reticulon","-","PF02453,Reticulon","IPR003388,Reticulon","ENOG410XPKH,-;KOG1792,Reticulon","GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0005783,cellular_component,endoplasmic reticulum;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["UBLCP1",12.86686138,6.367152147,1.013470011,4.729529583,0.000940088,0.002277811,"ENSG00000164332","W5PU58,Ubiquitin like domain containing CTD phosphatase 1","XP_004009079.1,-","PF03031,NLI interacting factor-like phosphatase;PF00240,Ubiquitin family","IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR011943,HAD-superfamily hydrolase, subfamily IIID;IPR004274,FCP1 homology domain;IPR000626,Ubiquitin domain;IPR029071,Ubiquitin-like domain superfamily","-","GO:0006470,biological_process,protein dephosphorylation;GO:0005730,cellular_component,nucleolus;GO:0005634,cellular_component,nucleus;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004722,molecular_function,protein serine/threonine phosphatase activity","-"]
["ZNF707",2.514592972,1.242914917,1.013414312,3.659470564,0.011330551,0.021245693,"ENSG00000181135","K7C1Q4,Zinc finger protein 707","XP_003312008.1,-;XP_003312007.1,zinc finger protein 707 isoform X2;XP_016815531.1,-;XP_016815532.1,-","PF00096,Zinc finger, C2H2 type;PF01352,KRAB box","IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily","KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger","GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular","-"]
["MYBBP1A",14.39384405,7.131156712,1.012677815,6.078692393,{"v":5.88e-05,"d":"5.88E-05"},1.87555E-4,"ENSG00000132382","K7A306,MYB binding protein","XP_016786745.1,myb-binding protein 1A isoform X2","PF04931,NA polymerase phi","IPR016024,Armadillo-type fold;IPR007015,DNA polymerase V","-","GO:0003887,molecular_function,DNA-directed DNA polymerase activity;GO:0003677,molecular_function,DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0071897,biological_process,DNA biosynthetic process","-"]
["KRT13",335.4440432,166.2501105,1.012665109,9.514850088,{"v":1.52e-06,"d":"1.52E-06"},{"v":6.95e-06,"d":"6.95E-06"},"ENSG00000171401","H2QCZ4,Uncharacterized protein","XP_003315487.1,-","PF00038,Intermediate filament protein","IPR018039,Intermediate filament protein, conserved site;IPR001664,Intermediate filament protein;IPR002957,Keratin, type I","ENOG410IFTF,-;ENOG410Y9IV,-","GO:0045095,cellular_component,keratin filament;GO:0007010,biological_process,cytoskeleton organization;GO:0005882,cellular_component,intermediate filament;GO:0045111,cellular_component,intermediate filament cytoskeleton;GO:0005198,molecular_function,structural molecule activity","-"]
["SF3A2",25.53416368,12.65069459,1.012580661,5.922696202,{"v":7.32e-05,"d":"7.32E-05"},2.28843E-4,"ENSG00000104897","H2QEW0,Splicing factor 3a, subunit 2, 66kDa","XP_001150681.1,-;XP_016790131.1,-","PF12874,Zinc-finger of C2H2 type;PF16835,Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)","IPR003604,Matrin/U1-C-like, C2H2-type zinc finger;IPR031781,SF3A2 domain;IPR036236,Zinc finger C2H2 superfamily;IPR000690,Matrin/U1-C, C2H2-type zinc finger","KOG0227,Splicing factor 3a, subunit 2;COG5246,Splicing factor 3a, subunit 2","GO:0005686,cellular_component,U2 snRNP;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0006397,biological_process,mRNA processing;GO:0003723,molecular_function,RNA binding;GO:0005681,cellular_component,spliceosomal complex;GO:0071013,cellular_component,catalytic step 2 spliceosome;GO:0000245,biological_process,spliceosomal complex assembly;GO:0071004,cellular_component,U2-type prespliceosome;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding","K12826,ko03040,Spliceosome"]
["CEP131",9.340338544,4.626614454,1.012154111,4.832591024,8.47662E-4,0.002081389,"ENSG00000141577","B2RN10,5-azacytidine induced 1","-","-","IPR030465,Centrosomal protein of 131kDa","ENOG410IEUN,-;ENOG410YVPU,-","GO:0005929,cellular_component,cilium;GO:0035735,biological_process,intraciliary transport involved in cilium assembly","-"]
["SPRYD3",12.35420704,6.121909724,1.011773956,5.041911973,0.000590169,0.001501834,"ENSG00000167778","F8VWW7,SPRY domain-containing protein 3","-","PF00622,SPRY domain","IPR001870,B30.2/SPRY domain;IPR035783,SPRY domain-containing protein 3, SPRY domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR003877,SPRY domain","ENOG410XPCC,-;KOG1477,SPRY domain-containing proteins","-","-"]
["MORC3",4.33564872,2.14760685,1.011700342,4.429983031,2.407728E-3,0.005368186,"ENSG00000159256","Q4VBZ9,MORC family CW-type zinc finger 3","NP_056173.1,MORC family CW-type zinc finger protein 3 isoform 1","PF07496,CW-type Zinc Finger;PF13589,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase","IPR003594,Histidine kinase/HSP90-like ATPase;IPR011124,Zinc finger, CW-type;IPR036890,Histidine kinase/HSP90-like ATPase superfamily","ENOG411033B,-;KOG1845,MORC family ATPases","GO:0046872,molecular_function,metal ion binding;GO:0008270,molecular_function,zinc ion binding","-"]
["EIF2AK2",9.341173761,4.63171614,1.011554588,6.247087472,{"v":4.32E-5,"d":"4.32E-05"},1.42485E-4,"ENSG00000055332","B9UKH9,Eukaryotic translation initiation factor 2-alpha kinase 2","NP_001266614.1,interferon-induced, double-stranded RNA-activated protein kinase","PF00069,Protein kinase domain;PF00035,ouble-stranded RNA binding motif","IPR014720,Double-stranded RNA-binding domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR033366,Interferon-induced, double-stranded RNA-activated protein kinase;IPR000719,Protein kinase domain","-","GO:0003723,molecular_function,RNA binding;GO:0016301,molecular_function,kinase activity;GO:0010998,biological_process,regulation of translational initiation by eIF2 alpha phosphorylation;GO:0009615,biological_process,response to virus;GO:0003743,molecular_function,translation initiation factor activity;GO:0045087,biological_process,innate immune response;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0016310,biological_process,phosphorylation;GO:0006413,biological_process,translational initiation;GO:0042981,biological_process,regulation of apoptotic process;GO:0045071,biological_process,negative regulation of viral genome replication;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0003725,molecular_function,double-stranded RNA binding;GO:0009636,biological_process,response to toxic substance;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0004672,molecular_function,protein kinase activity","-"]
["NR2C1",1.927613371,0.953531239,1.011449457,3.34168384,0.021157844,0.03690583,"ENSG00000120798","H9NIM2,Nuclear receptor subfamily 2, group C, member 1, isoform CRA_c","NP_003288.2,nuclear receptor subfamily 2 group C member 1 isoform a","PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor","IPR001628,Zinc finger, nuclear hormone receptor-type;IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR013088,Zinc finger, NHR/GATA-type","KOG3575,FOG: Hormone receptors;ENOG410XRZC,-","GO:0042826,molecular_function,histone deacetylase binding;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0048386,biological_process,positive regulation of retinoic acid receptor signaling pathway;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0046872,molecular_function,metal ion binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0016605,cellular_component,PML body;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway","-"]
["ZNF720",1.282129961,0.634230385,1.011449457,3.34168384,0.021157844,0.03690583,"ENSG00000197302","G3SH29,Uncharacterized protein","-","-","-","-","-","-"]
["CADM4",5.603467364,2.771863516,1.011449457,3.34168384,0.021157844,0.03690583,"ENSG00000105767","A0A0D9S1C9,Cell adhesion molecule 4","XP_007995234.1,-","PF13927,Immunoglobulin domain;PF08205,CD80-like C2-set immunoglobulin domain;PF07686,Immunoglobulin V-set domain","IPR007110,Immunoglobulin-like domain;IPR028807,Cell adhesion molecule 4;IPR013162,CD80-like, immunoglobulin C2-set;IPR036179,Immunoglobulin-like domain superfamily;IPR003585,Neurexin/syndecan/glycophorin C;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013106,Immunoglobulin V-set domain;IPR013783,Immunoglobulin-like fold","-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["TBPL1",2.497596289,1.235484314,1.011449457,3.34168384,0.021157844,0.03690583,"ENSG00000028839","I3M8I5,TATA-box binding protein like 1","XP_005329833.1,-","PF00352,Transcription factor TFIID (or TATA-binding protein, TBP)","IPR012295,TBP domain superfamily;IPR000814,TATA-box binding protein;IPR015445,TATA-Box binding protein-like","COG2101,TATA-box binding protein (TBP), component of TFIID and TFIIIB;KOG3302,TATA-box binding protein (TBP), component of TFIID and TFIIIB","GO:0007283,biological_process,spermatogenesis;GO:0007289,biological_process,spermatid nucleus differentiation;GO:0003677,molecular_function,DNA binding;GO:0006235,biological_process,dTTP biosynthetic process;GO:0005737,cellular_component,cytoplasm;GO:0005672,cellular_component,transcription factor TFIIA complex;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006352,biological_process,DNA-templated transcription, initiation;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0001675,biological_process,acrosome assembly","-"]
["RWDD4P2",22.35415222,11.05791378,1.011449457,3.34168384,0.021157844,0.03690583,"ENSG00000175741","H2QQH7,RWD domain containing 4","-","PF05773,RWD domain","IPR006575,RWD domain;IPR016135,Ubiquitin-conjugating enzyme/RWD-like","ENOG410XT0M,-;KOG4018,Uncharacterized conserved protein, contains RWD domain","-","-"]
["ZNF746",1.523654685,0.753705261,1.011449457,3.34168384,0.021157844,0.03690583,"ENSG00000181220","G3RUL6,Zinc finger protein 746","-","PF12417,Zinc finger protein;PF00096,Zinc finger, C2H2 type;PF01352,KRAB box;PF13912,C2H2-type zinc finger","-","-","-","-"]
["MECP2",4.964864194,2.462025233,1.011355407,6.109138683,{"v":5.17e-05,"d":"5.17E-05"},0.000167187,"ENSG00000169057","K7B3Z3,Methyl-CpG-binding protein 2","XP_521333.3,-","PF01429,Methyl-CpG binding domain","IPR001739,Methyl-CpG DNA binding;IPR017353,Methyl-CpG binding protein MeCP2;IPR016177,DNA-binding domain superfamily","ENOG41126JX,-;KOG4161,Methyl-CpG binding transcription regulators","GO:0016525,biological_process,negative regulation of angiogenesis;GO:0019904,molecular_function,protein domain specific binding;GO:0003677,molecular_function,DNA binding;GO:0000792,cellular_component,heterochromatin;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0000930,cellular_component,gamma-tubulin complex;GO:0005813,cellular_component,centrosome;GO:0043537,biological_process,negative regulation of blood vessel endothelial cell migration;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0047485,molecular_function,protein N-terminus binding;GO:0010385,molecular_function,double-stranded methylated DNA binding;GO:0090063,biological_process,positive regulation of microtubule nucleation;GO:0010629,biological_process,negative regulation of gene expression;GO:0006351,biological_process,transcription, DNA-templated;GO:0010971,biological_process,positive regulation of G2/M transition of mitotic cell cycle;GO:0007052,biological_process,mitotic spindle organization;GO:1905643,biological_process,positive regulation of DNA methylation;GO:0005634,cellular_component,nucleus;GO:0006355,biological_process,regulation of transcription, DNA-templated","-"]
["MGST1",7.372754511,3.655385207,1.011260505,5.386742883,2.43348E-4,0.000677308,"ENSG00000008394","G3QV01,Microsomal glutathione S-transferase 1","XP_018894339.1,-;XP_004052872.1,-;XP_004052873.1,-","PF01124,MAPEG family","IPR023352,Membrane associated eicosanoid/glutathione metabolism-like domain superfamily;IPR001129,Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein","-","GO:0071449,biological_process,cellular response to lipid hydroperoxide;GO:0098869,biological_process,cellular oxidant detoxification;GO:0004602,molecular_function,glutathione peroxidase activity;GO:0005739,cellular_component,mitochondrion;GO:0004364,molecular_function,glutathione transferase activity;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane","K00799,ko00982,Drug metabolism - cytochrome P450;K00799,ko01524,Platinum drug resistance;K00799,ko05204,Chemical carcinogenesis;K00799,ko00980,Metabolism of xenobiotics by cytochrome P450;K00799,ko00480,Glutathione metabolism"]
["ARPC2",71.36107993,35.40283184,1.011164986,8.455906667,{"v":2.7E-6,"d":"2.70E-06"},{"v":1.16e-05,"d":"1.16E-05"},"ENSG00000163466","I3MPB0,Arp2/3 complex 34 kDa subunit","XP_005330514.1,-","PF04045,Arp2/3 complex, 34 kD subunit p34-Arc","IPR007188,Actin-related protein 2/3 complex subunit 2;IPR034666,Arp2/3 complex subunit 2/4","ENOG410YKF6,-;KOG2826,Actin-related protein Arp2/3 complex, subunit ARPC2","GO:0031252,cellular_component,cell leading edge;GO:0030041,biological_process,actin filament polymerization;GO:0030838,biological_process,positive regulation of actin filament polymerization;GO:0005856,cellular_component,cytoskeleton;GO:0010592,biological_process,positive regulation of lamellipodium assembly;GO:0015629,cellular_component,actin cytoskeleton;GO:0030833,biological_process,regulation of actin filament polymerization;GO:0005768,cellular_component,endosome;GO:0030027,cellular_component,lamellipodium;GO:0005737,cellular_component,cytoplasm;GO:0005886,cellular_component,plasma membrane;GO:0003779,molecular_function,actin binding;GO:0005885,cellular_component,Arp2/3 protein complex;GO:1900026,biological_process,positive regulation of substrate adhesion-dependent cell spreading;GO:0034314,biological_process,Arp2/3 complex-mediated actin nucleation;GO:0051015,molecular_function,actin filament binding;GO:0005925,cellular_component,focal adhesion;GO:0036195,cellular_component,muscle cell projection membrane;GO:0005200,molecular_function,structural constituent of cytoskeleton","-"]
["GRPEL2",8.97394077,4.448926613,1.011012385,4.928762222,0.00076887,1.903603E-3,"ENSG00000164284","Q8N3S0,GrpE protein homolog","-","PF01025,rpE","IPR013805,GrpE nucleotide exchange factor, coiled-coil;IPR009012,GrpE nucleotide exchange factor, head;IPR000740,GrpE nucleotide exchange factor","KOG3003,Molecular chaperone of the GrpE family;COG0576,Molecular chaperone GrpE (heat shock protein)","GO:0051087,molecular_function,chaperone binding;GO:0042803,molecular_function,protein homodimerization activity;GO:0006457,biological_process,protein folding;GO:0050790,biological_process,regulation of catalytic activity;GO:0005739,cellular_component,mitochondrion;GO:0000774,molecular_function,adenyl-nucleotide exchange factor activity;GO:0005759,cellular_component,mitochondrial matrix","-"]
["RHOA",61.89414321,30.71051654,1.010754706,6.911587549,{"v":1.3e-05,"d":"1.30E-05"},{"v":4.84e-05,"d":"4.84E-05"},"ENSG00000067560","I3M4G3,Uncharacterized protein","XP_005326975.1,-","PF00071,Ras family","IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR003578,Small GTPase superfamily, Rho type;IPR027417,P-loop containing nucleoside triphosphate hydrolase","COG1100,GTPase SAR1 and related small G proteins;KOG0393,Ras-related small GTPase, Rho type","GO:1903673,biological_process,mitotic cleavage furrow formation;GO:0045792,biological_process,negative regulation of cell size;GO:0035385,biological_process,Roundabout signaling pathway;GO:1902766,biological_process,skeletal muscle satellite cell migration;GO:0005525,molecular_function,GTP binding;GO:0036089,biological_process,cleavage furrow formation;GO:0031532,biological_process,actin cytoskeleton reorganization;GO:0060193,biological_process,positive regulation of lipase activity;GO:0090051,biological_process,negative regulation of cell migration involved in sprouting angiogenesis;GO:1990869,biological_process,cellular response to chemokine;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043542,biological_process,endothelial cell migration;GO:0032956,biological_process,regulation of actin cytoskeleton organization;GO:0038027,biological_process,apolipoprotein A-I-mediated signaling pathway;GO:0043296,cellular_component,apical junction complex;GO:0043149,biological_process,stress fiber assembly;GO:0031982,cellular_component,vesicle;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0034329,biological_process,cell junction assembly;GO:0045666,biological_process,positive regulation of neuron differentiation;GO:0007266,biological_process,Rho protein signal transduction;GO:0050919,biological_process,negative chemotaxis;GO:0003924,molecular_function,GTPase activity;GO:0005829,cellular_component,cytosol;GO:0032467,biological_process,positive regulation of cytokinesis;GO:0097498,biological_process,endothelial tube lumen extension;GO:0017022,molecular_function,myosin binding;GO:0090307,biological_process,mitotic spindle assembly;GO:0030334,biological_process,regulation of cell migration;GO:0043297,biological_process,apical junction assembly;GO:0005768,cellular_component,endosome;GO:0032154,cellular_component,cleavage furrow;GO:0071222,biological_process,cellular response to lipopolysaccharide;GO:0043197,cellular_component,dendritic spine;GO:2000406,biological_process,positive regulation of T cell migration;GO:0044319,biological_process,wound healing, spreading of cells;GO:0000166,molecular_function,nucleotide binding;GO:0071902,biological_process,positive regulation of protein serine/threonine kinase activity;GO:0045198,biological_process,establishment of epithelial cell apical/basal polarity;GO:0051496,biological_process,positive regulation of stress fiber assembly;GO:0071944,cellular_component,cell periphery;GO:0005622,cellular_component,intracellular;GO:0031234,cellular_component,extrinsic component of cytoplasmic side of plasma membrane;GO:0016477,biological_process,cell migration;GO:0005938,cellular_component,cell cortex","-"]
["MAP3K2",4.477654808,2.22086798,1.010641383,5.298447471,0.00029599,0.000806803,"ENSG00000169967","G1S0P6,Mitogen-activated protein kinase kinase kinase 2","XP_004091668.1,-","PF00069,Protein kinase domain;PF00564,PB1 domain","IPR034879,Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain;IPR011009,Protein kinase-like domain superfamily;IPR000270,PB1 domain;IPR017441,Protein kinase, ATP binding site;IPR000719,Protein kinase domain","KOG0198,MEKK and related serine/threonine protein kinases;ENOG410XQGS,-","GO:0019901,molecular_function,protein kinase binding;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0071260,biological_process,cellular response to mechanical stimulus;GO:0004672,molecular_function,protein kinase activity;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0005524,molecular_function,ATP binding;GO:0005654,cellular_component,nucleoplasm","K04420,ko04540,Gap junction;K04420,ko04010,MAPK signaling pathway;K04420,ko04912,GnRH signaling pathway"]
["CCT5",56.65045083,28.11429799,1.010631062,7.956039439,{"v":4.09e-06,"d":"4.09E-06"},{"v":1.7E-5,"d":"1.70E-05"},"ENSG00000150753","A0A1D5Q8I4,Chaperonin containing TCP1 subunit 5","NP_001245118.1,-","-","IPR017998,Chaperone tailless complex polypeptide 1 (TCP-1);IPR027413,GroEL-like equatorial domain superfamily;IPR027409,GroEL-like apical domain superfamily;IPR012718,T-complex protein 1, epsilon subunit;IPR027410,TCP-1-like chaperonin intermediate domain superfamily;IPR002423,Chaperonin Cpn60/TCP-1 family;IPR002194,Chaperonin TCP-1, conserved site","COG0459,Chaperonin GroEL (HSP60 family);KOG0357,Chaperonin complex component, TCP-1 epsilon subunit (CCT5)","GO:0005737,cellular_component,cytoplasm;GO:0006457,biological_process,protein folding;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0051082,molecular_function,unfolded protein binding","-"]
["MSL3",3.765147008,1.866309647,1.010456508,4.252986546,0.003617419,0.007686179,"ENSG00000005302","K7BWJ5,Male-specific lethal 3 homolog","XP_016799303.1,-","PF11717,RNA binding activity-knot of a chromodomain;PF05712,MRG","IPR038217,MRG, C-terminal domain superfamily;IPR037921,Male-specific lethal 3 homolog;IPR025995,RNA binding activity-knot of a chromodomain;IPR016197,Chromo-like domain superfamily;IPR008676,MRG;IPR000953,Chromo/chromo shadow domain;IPR026541,MRG domain","KOG3001,Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins;ENOG410XR9F,-","GO:0003677,molecular_function,DNA binding;GO:0006325,biological_process,chromatin organization;GO:0043984,biological_process,histone H4-K16 acetylation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0072487,cellular_component,MSL complex;GO:0035064,molecular_function,methylated histone binding;GO:0005634,cellular_component,nucleus","-"]
["VPS37C",7.675479443,3.806191534,1.010250693,4.555895699,0.00160548,0.003703697,"ENSG00000167987","B4DYD9,cDNA FLJ61465, highly similar to Homo sapiens vacuolar protein sorting 37C","-","PF07200,Modifier of rudimentary (Mod(r)) protein","IPR009851,Modifier of rudimentary, Modr;IPR037859,Vacuolar protein sorting-associated protein 37;IPR037202,ESCRT assembly domain","KOG3270,Uncharacterized conserved protein;ENOG4111UJN,-","GO:0015031,biological_process,protein transport;GO:0000813,cellular_component,ESCRT I complex;GO:0032509,biological_process,endosome transport via multivesicular body sorting pathway","-"]
["GPT2",5.717878852,2.836243229,1.010112091,4.80594973,0.001026186,0.002471847,"ENSG00000166123","G3RJK4,Glutamic--pyruvic transaminase 2","XP_004057650.1,-","PF00155,Aminotransferase class I and II","IPR015421,Pyridoxal phosphate-dependent transferase, major domain;IPR015422,Pyridoxal phosphate-dependent transferase domain 1;IPR015424,Pyridoxal phosphate-dependent transferase;IPR004839,Aminotransferase, class I/classII","-","GO:0030170,molecular_function,pyridoxal phosphate binding;GO:0006103,biological_process,2-oxoglutarate metabolic process;GO:0004021,molecular_function,L-alanine:2-oxoglutarate aminotransferase activity;GO:0003824,molecular_function,catalytic activity;GO:0005739,cellular_component,mitochondrion;GO:0009058,biological_process,biosynthetic process;GO:0042851,biological_process,L-alanine metabolic process","K00814,ko01200,Carbon metabolism;K00814,ko01230,Biosynthesis of amino acids;K00814,ko01210,2-Oxocarboxylic acid metabolism;K00814,ko00250,Alanine, aspartate and glutamate metabolism;K00814,ko00220,Arginine biosynthesis;K00814,ko00710,Carbon fixation in photosynthetic organisms"]
["TCEAL8",29.73109839,14.7475364,1.010112091,4.80594973,0.001026186,0.002471847,"ENSG00000180964","H2RF56,Transcription elongation factor A","NP_001238932.1,-;XP_016802882.1,-;XP_009437683.1,-","PF04538,Brain expressed X-linked like family","IPR021156,Transcription elongation factor A-like/Brain expressed X-linked","ENOG4111DNR,-;ENOG410JBTZ,-","GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0050699,molecular_function,WW domain binding;GO:0003746,molecular_function,translation elongation factor activity;GO:0005634,cellular_component,nucleus;GO:0006414,biological_process,translational elongation","-"]
["RP11-21J18.1",99.95941354,49.6176074,1.010010474,6.310322186,{"v":3.87e-05,"d":"3.87E-05"},0.000128853,"ENSG00000265257","G3SIH9,Uncharacterized protein","-","PF01257,Thioredoxin-like [2Fe-2S] ferredoxin","IPR002023,NADH-quinone oxidoreductase subunit E-like;IPR036249,Thioredoxin-like superfamily","-","GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0051537,molecular_function,2 iron, 2 sulfur cluster binding;GO:0046872,molecular_function,metal ion binding","-"]
["TMEM183A",12.62207429,6.266787201,1.009161116,5.279225143,0.00030625,0.000831391,"ENSG00000163444","H9ZFD8,Transmembrane protein 183A","NP_001253210.1,-","-","IPR026509,Transmembrane protein 183;IPR036047,F-box-like domain superfamily","ENOG410IK0T,-;ENOG4110BNJ,-","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["RPSA",132.5457163,65.84903076,1.009159533,8.612092358,{"v":2.47e-06,"d":"2.47E-06"},{"v":1.08E-5,"d":"1.08E-05"},"ENSG00000168028","A0A0C4DG17,40S ribosomal protein SA","NP_001291217.1,40S ribosomal protein SA isoform 2","PF00318,Ribosomal protein S2;PF16122,40S ribosomal protein SA C-terminus","IPR005707,Ribosomal protein S2, eukaryotic/archaeal;IPR023591,Ribosomal protein S2, flavodoxin-like domain superfamily;IPR018130,Ribosomal protein S2, conserved site;IPR032281,40S ribosomal protein SA, C-terminal domain;IPR027498,Ribosomal protein S2, eukaryotic;IPR001865,Ribosomal protein S2;IPR027504,40S ribosomal protein SA","KOG0830,40S ribosomal protein SA (P40)/Laminin receptor 1;COG0052,Ribosomal protein S2","GO:0005055,molecular_function,laminin receptor activity;GO:0043025,cellular_component,neuronal cell body;GO:0007155,biological_process,cell adhesion;GO:0030855,biological_process,epithelial cell differentiation;GO:0098609,biological_process,cell-cell adhesion;GO:0031012,cellular_component,extracellular matrix;GO:0005622,cellular_component,intracellular;GO:0003735,molecular_function,structural constituent of ribosome;GO:0000028,biological_process,ribosomal small subunit assembly;GO:0043236,molecular_function,laminin binding;GO:0005840,cellular_component,ribosome;GO:0005737,cellular_component,cytoplasm;GO:0005886,cellular_component,plasma membrane;GO:0022627,cellular_component,cytosolic small ribosomal subunit;GO:0015935,cellular_component,small ribosomal subunit;GO:0005829,cellular_component,cytosol;GO:0016020,cellular_component,membrane;GO:0005604,cellular_component,basement membrane;GO:0005634,cellular_component,nucleus;GO:0030529,,;GO:0006412,biological_process,translation","-"]
["PELP1",22.56539316,11.20940781,1.009063001,6.806138204,{"v":1.58e-05,"d":"1.58E-05"},{"v":5.76e-05,"d":"5.76E-05"},"ENSG00000141456","C9JFV4,Proline-, glutamic acid- and leucine-rich protein 1","NP_055204.3,proline-, glutamic acid- and leucine-rich protein 1 isoform 1","PF08166,NUC202 domain;PF08167,rRNA processing/ribosome biogenesis","IPR016024,Armadillo-type fold;IPR012980,Uncharacterised domain NUC202;IPR031193,Proline-, glutamic acid- and leucine-rich protein 1;IPR012583,Pre-rRNA-processing protein RIX1, N-terminal","ENOG4110K7C,-;ENOG410IJ4S,-","GO:0071391,biological_process,cellular response to estrogen stimulus;GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus","-"]
["SNORD49B",458.4300027,227.5440591,1.009031374,4.671664273,1.408142E-3,0.003284235,"-","-","-","-","-","-","-","-"]
["SGSM3",5.675148126,2.816394392,1.008950245,4.394617479,0.002324379,0.005191704,"ENSG00000100359","G3RGQ0,Small G protein signaling modulator 3","XP_018873997.1,small G protein signaling modulator 3 isoform X5","PF00566,Rab-GTPase-TBC domain;PF00018,SH3 domain;PF02759,RUN domain","IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain;IPR037213,RUN domain superfamily;IPR004012,RUN domain;IPR036028,SH3-like domain superfamily;IPR001452,SH3 domain;IPR035833,SGSM3, SH3 domain","-","-","-"]
["ST3GAL1",2.421119593,1.201194895,1.00882362,4.051056219,0.00570313,0.011549071,"ENSG00000008513","A0A024R9L6,ST3 beta-galactoside alpha-2,3-sialyltransferase 1, isoform CRA_a","NP_003024.1,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1;XP_016869225.1,-;XP_016869226.1,-;XP_011515527.1,-;XP_006716680.1,-;XP_005251082.1,-;NP_775479.1,-","PF00777,lycosyltransferase family 29 (sialyltransferase)","IPR012163,Sialyltransferase;IPR038578,GT29-like superfamiliy;IPR001675,Glycosyl transferase family 29","KOG2692,Sialyltransferase;ENOG410XT8P,-","GO:0005794,cellular_component,Golgi apparatus;GO:0097503,biological_process,sialylation;GO:0006486,biological_process,protein glycosylation;GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane;GO:0008373,molecular_function,sialyltransferase activity;GO:0003836,molecular_function,beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0006468,biological_process,protein phosphorylation;GO:0016021,cellular_component,integral component of membrane","K00780,ko00604,Glycosphingolipid biosynthesis - ganglio series;K00780,ko00603,Glycosphingolipid biosynthesis - globo series;K00780,ko00512,Mucin type O-Glycan biosynthesis;K00780,ko00533,Glycosaminoglycan biosynthesis - keratan sulfate"]
["GPR180",1.0497558,0.519982797,1.008085379,2.932345556,0.043825627,0.069982717,"ENSG00000152749","H2Q7P9,G protein-coupled receptor 180","XP_522698.2,-","PF10192,Rhodopsin-like GPCR transmembrane domain","IPR019336,Intimal thickness related receptor, IRP","KOG4290,Predicted membrane protein;ENOG410XRGS,-","GO:0019236,biological_process,response to pheromone;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ELMOD3",1.275788079,0.631944928,1.008085379,2.932345556,0.043825627,0.069982717,"ENSG00000115459","H2QI90,Uncharacterized protein","-","PF04727,LMO/CED-12 family","-","-","-","-"]
["METTL21A",1.362304452,0.674799681,1.008085379,2.932345556,0.043825627,0.069982717,"ENSG00000144401","H7BXH9,Protein N-lysine methyltransferase METTL21A","XP_006712390.1,-;XP_005246394.1,-;XP_005246393.1,-;NP_001317066.1,protein N-lysine methyltransferase METTL21A isoform 4","PF10294,Lysine methyltransferase","IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR019410,Lysine methyltransferase","-","-","-"]
["TMEM120A",4.637428976,2.29708975,1.008085379,2.932345556,0.043825627,0.069982717,"ENSG00000189077","A0A087X266,Transmembrane protein 120A","NP_001304732.1,transmembrane protein 120A isoform 2","PF07851,TMPIT-like protein","IPR012926,TMPIT-like","-","GO:0051260,biological_process,protein homooligomerization;GO:0016020,cellular_component,membrane;GO:0051291,biological_process,protein heterooligomerization;GO:0016021,cellular_component,integral component of membrane;GO:0045444,biological_process,fat cell differentiation","-"]
["INTS10",5.185474129,2.575895477,1.007991531,4.778805011,0.001079559,0.00259149,"ENSG00000104613","K7CL17,Integrator complex subunit 10","XP_016814667.1,-","-","IPR026164,Integrator complex subunit 10","-","GO:0032039,cellular_component,integrator complex;GO:0016180,biological_process,snRNA processing","-"]
["CTDNEP1",23.98494502,11.91964545,1.007977463,5.560880908,0.000166535,4.80123E-4,"ENSG00000175826","A0A250YDB3,CTD nuclear envelope phosphatase 1","-","-","IPR004274,FCP1 homology domain;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR011948,Dullard phosphatase domain, eukaryotic","-","GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity","-"]
["MGAT1",5.353930366,2.660708694,1.007977463,5.560880908,0.000166535,4.80123E-4,"ENSG00000131446","Q59G70,Mannosyl","-","PF03071,NT-I family","IPR004139,Glycosyl transferase, family 13;IPR029044,Nucleotide-diphospho-sugar transferases","KOG1413,N-acetylglucosaminyltransferase I;ENOG410XQD8,-","GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0006486,biological_process,protein glycosylation;GO:0008375,molecular_function,acetylglucosaminyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["ZBTB40",2.640793431,1.311819842,1.007287906,4.212912423,0.003508491,0.007468538,"ENSG00000184677","G3R3E8,Zinc finger and BTB domain containing 40","XP_004024905.1,-;XP_004024904.1,zinc finger and BTB domain-containing protein 40","PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type;PF00651,BTB/POZ domain","IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR030404,Zinc finger and BTB domain-containing protein 40;IPR036236,Zinc finger C2H2 superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0005634,cellular_component,nucleus","-"]
["ACSF2",4.096259191,2.034825603,1.007287906,4.212912423,0.003508491,0.007468538,"ENSG00000167107","H2QDF1,Acyl-CoA synthetase family member 2","-","PF00501,AMP-binding enzyme;PF13193,AMP-binding enzyme C-terminal domain","IPR000873,AMP-dependent synthetase/ligase;IPR025110,AMP-binding enzyme, C-terminal domain;IPR020845,AMP-binding, conserved site","KOG1177,Long chain fatty acid acyl-CoA ligase;COG0318,Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II","GO:0003824,molecular_function,catalytic activity;GO:0008152,biological_process,metabolic process","-"]
["SCAND2P",1.661800028,0.825502754,1.006585303,3.815959617,0.009528469,0.018276716,"ENSG00000176700","Q8NF73,FLJ00296 protein","-","-","IPR036322,WD40-repeat-containing domain superfamily","ENOG410XNU9,-;KOG0264,Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1","-","-"]
["NFE2L3",4.191459378,2.082116502,1.006585303,3.815959617,0.009528469,0.018276716,"ENSG00000050344","A4D178,Nuclear factor","-","PF03131,bZIP Maf transcription factor","IPR029854,Nuclear factor erythroid 2-related factor 3;IPR008917,Transcription factor, Skn-1-like, DNA-binding domain superfamily;IPR004826,Basic leucine zipper domain, Maf-type;IPR004827,Basic-leucine zipper domain","ENOG410ZGMS,-;KOG3863,bZIP transcription factor NRF1","GO:0003677,molecular_function,DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus","-"]
["IRF2BPL",6.340648575,3.152883763,1.006057351,4.358357719,0.00248181,0.005483973,"ENSG00000119669","K7CMY2,Interferon regulatory factor 2 binding protein-like","-","PF11261,Interferon regulatory factor 2-binding protein zinc finger","IPR022750,Interferon regulatory factor 2-binding protein 1 & 2, zinc finger","ENOG410Z1AW,-;KOG3579,Predicted E3 ubiquitin ligase","-","-"]
["MTX1",3.622027841,1.799250156,1.00518315,3.264947626,0.029771772,0.050043569,"ENSG00000173171","A0A0A0MRK6,Metaxin 1, isoform CRA_b","-","PF10568,Outer mitochondrial membrane transport complex protein;PF17171,lutathione S-transferase, C-terminal domain","IPR019564,Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain;IPR036282,Glutathione S-transferase, C-terminal domain superfamily;IPR033468,Metaxin, glutathione S-transferase domain","-","GO:0007595,biological_process,lactation;GO:0005741,cellular_component,mitochondrial outer membrane;GO:0016021,cellular_component,integral component of membrane;GO:0006626,biological_process,protein targeting to mitochondrion;GO:0016020,cellular_component,membrane","-"]
["FAM101A",3.741886941,1.858790423,1.00518315,3.264947626,0.029771772,0.050043569,"ENSG00000178882","A0A0D9S564,Uncharacterized protein","XP_008003346.1,protein FAM101A isoform X1","PF15068,AM101 family","IPR028215,Refilin family","-","GO:0061182,biological_process,negative regulation of chondrocyte development;GO:1900158,biological_process,negative regulation of bone mineralization involved in bone maturation;GO:0061572,biological_process,actin filament bundle organization;GO:0061181,biological_process,regulation of chondrocyte development;GO:0048705,biological_process,skeletal system morphogenesis;GO:0032432,cellular_component,actin filament bundle;GO:0031005,molecular_function,filamin binding","-"]
["HYAL2",2.61232283,1.29767701,1.00518315,3.264947626,0.029771772,0.050043569,"ENSG00000068001","A0A024R300,Hyaluronidase","-","PF01630,Hyaluronidase","IPR018155,Hyaluronidase;IPR017853,Glycoside hydrolase superfamily;IPR013785,Aldolase-type TIM barrel","ENOG410IECJ,-;ENOG410XPZT,-","GO:0016798,molecular_function,hydrolase activity, acting on glycosyl bonds;GO:0005975,biological_process,carbohydrate metabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0003824,molecular_function,catalytic activity;GO:0004415,molecular_function,hyalurononglucosaminidase activity;GO:0008152,biological_process,metabolic process","-"]
["LCA5",1.990779219,0.988923879,1.00518315,3.264947626,0.029771772,0.050043569,"ENSG00000135338","G3QXC4,LCA5, lebercilin","XP_004044370.1,lebercilin;XP_018885464.1,-","PF15619,Ciliary protein causing Leber congenital amaurosis disease","IPR026188,Lebercilin-like;IPR026684,Lebercilin;IPR028933,Lebercilin domain","-","GO:0005929,cellular_component,cilium","-"]
["PIK3R3",2.662178659,1.324151584,1.005088198,4.004821277,0.005565457,0.011294438,"ENSG00000278139","F6TDL0,Uncharacterized protein","NP_001290356.1,LOC110117498-PIK3R3 readthrough","PF00017,SH2 domain;PF16454,Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain","IPR036860,SH2 domain superfamily;IPR032498,PI3K p85 subunit, inter-SH2 domain;IPR035022,PI3K p85 subunit, N-terminal SH2 domain;IPR035020,PI3K p85 subunit, C-terminal SH2 domain;IPR000980,SH2 domain;IPR001720,PI3K p85/p55 subunit","ENOG410XP6R,-;KOG4637,Adaptor for phosphoinositide 3-kinase","GO:0046935,molecular_function,1-phosphatidylinositol-3-kinase regulator activity;GO:2001275,biological_process,positive regulation of glucose import in response to insulin stimulus;GO:0043551,biological_process,regulation of phosphatidylinositol 3-kinase activity;GO:0008286,biological_process,insulin receptor signaling pathway;GO:0005942,cellular_component,phosphatidylinositol 3-kinase complex;GO:0035014,molecular_function,phosphatidylinositol 3-kinase regulator activity;GO:0046854,biological_process,phosphatidylinositol phosphorylation","-"]
["ME2",2.181092865,1.084862416,1.005088198,4.004821277,0.005565457,0.011294438,"ENSG00000082212","G3R5I4,Malic enzyme","XP_004059473.1,-","PF00390,Malic enzyme, N-terminal domain;PF03949,Malic enzyme, NAD binding domain","IPR036291,NAD(P)-binding domain superfamily;IPR037062,Malic enzyme, N-terminal domain superfamily;IPR012301,Malic enzyme, N-terminal domain;IPR012302,Malic enzyme, NAD-binding;IPR001891,Malic oxidoreductase;IPR015884,Malic enzyme, conserved site","-","GO:0051287,molecular_function,NAD binding;GO:0004470,molecular_function,malic enzyme activity;GO:0046872,molecular_function,metal ion binding;GO:1902031,biological_process,regulation of NADP metabolic process;GO:0016491,molecular_function,oxidoreductase activity;GO:0005739,cellular_component,mitochondrion;GO:0055114,biological_process,oxidation-reduction process;GO:0004471,molecular_function,malate dehydrogenase (decarboxylating) (NAD+) activity","K00027,ko00620,Pyruvate metabolism;K00027,ko01200,Carbon metabolism;K00027,ko02020,Two-component system"]
["NPDC1",7.461297952,3.71120453,1.005088198,4.004821277,0.005565457,0.011294438,"ENSG00000107281","Q5SPY9,Neural proliferation differentiation and control protein 1","-","PF06809,Neural proliferation differentiation control-1 protein (NPDC1)","IPR009635,Neural proliferation differentiation control-1","ENOG4111QDP,-;KOG3884,Neural proliferation, differentiation and control protein","GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane","-"]
["ZDHHC9",3.895016688,1.937357772,1.005088198,4.004821277,0.005565457,0.011294438,"ENSG00000188706","K7CVY0,Palmitoyltransferase","XP_016799345.1,-;XP_016799344.1,-","PF01529,HHC palmitoyltransferase","IPR030292,Palmitoyltransferase ZDHHC9;IPR001594,Palmitoyltransferase, DHHC domain","-","GO:0005794,cellular_component,Golgi apparatus;GO:0043849,molecular_function,Ras palmitoyltransferase activity;GO:0019706,molecular_function,protein-cysteine S-palmitoyltransferase activity;GO:0018230,biological_process,peptidyl-L-cysteine S-palmitoylation;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0018345,biological_process,protein palmitoylation;GO:0016409,molecular_function,palmitoyltransferase activity;GO:0016020,cellular_component,membrane;GO:0002178,cellular_component,palmitoyltransferase complex;GO:0005829,cellular_component,cytosol;GO:0031228,cellular_component,intrinsic component of Golgi membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016021,cellular_component,integral component of membrane","K16675,ko04391,Hippo signaling pathway - fly"]
["WDR70",9.344574548,4.654971517,1.00459667,5.646426794,0.000153198,4.4631E-4,"ENSG00000082068","A8K564,cDNA FLJ76716, highly similar to Homo sapiens WD repeat domain 70","-","PF00400,WD domain, G-beta repeat","IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR019775,WD40 repeat, conserved site;IPR001680,WD40 repeat;IPR017986,WD40-repeat-containing domain","KOG0772,Uncharacterized conserved protein, contains WD40 repeat;ENOG410XP76,-","-","-"]
["KDM5A",7.07018876,3.522971455,1.00437141,6.019388743,{"v":7.67e-05,"d":"7.67E-05"},0.00023831,"ENSG00000073614","K7B4D0,Lysine","-","PF00628,PHD-finger;PF02375,jmjN domain;PF08429,PLU-1-like protein;PF02373,JmjC domain, hydroxylase;PF02928,C5HC2 zinc finger;PF01388,ARID/BRIGHT DNA binding domain","IPR001606,ARID DNA-binding domain;IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR013637,Lysine-specific demethylase-like domain;IPR003349,JmjN domain;IPR036431,ARID DNA-binding domain superfamily;IPR019787,Zinc finger, PHD-finger;IPR004198,Zinc finger, C5HC2-type;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR019786,Zinc finger, PHD-type, conserved site;IPR003347,JmjC domain","KOG1246,DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain;ENOG410XR9J,-","GO:0032259,biological_process,methylation;GO:0003677,molecular_function,DNA binding;GO:0008168,molecular_function,methyltransferase activity;GO:0046872,molecular_function,metal ion binding;GO:0005634,cellular_component,nucleus","-"]
["SLC25A4",2.990311491,1.48814942,1.003328205,3.534549051,0.017095036,0.030632492,"ENSG00000151729","F6QA37,ADP/ATP translocase 1","NP_001245094.1,-","PF00153,Mitochondrial carrier protein","IPR018108,Mitochondrial substrate/solute carrier;IPR023395,Mitochondrial carrier domain superfamily;IPR002113,Adenine nucleotide translocator 1;IPR002067,Mitochondrial carrier protein","ENOG410XNW0,-;KOG0749,Mitochondrial ADP/ATP carrier proteins","GO:0005471,molecular_function,ATP:ADP antiporter activity;GO:0022857,molecular_function,transmembrane transporter activity;GO:0015866,biological_process,ADP transport;GO:0043209,cellular_component,myelin sheath;GO:0055085,biological_process,transmembrane transport;GO:0060546,biological_process,negative regulation of necroptotic process;GO:0008637,biological_process,apoptotic mitochondrial changes;GO:0015867,biological_process,ATP transport;GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005739,cellular_component,mitochondrion;GO:0046902,biological_process,regulation of mitochondrial membrane permeability;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane","K05863,ko04020,Calcium signaling pathway;K05863,ko04022,cGMP-PKG signaling pathway;K05863,ko05166,HTLV-I infection;K05863,ko05012,Parkinson's disease;K05863,ko05016,Huntington's disease"]
["GOLM1",37.24865024,18.57765812,1.003303079,6.894732365,{"v":1.62e-05,"d":"1.62E-05"},{"v":5.88e-05,"d":"5.88E-05"},"ENSG00000135052","B3KNK9,Epididymis luminal protein 46","NP_808800.1,-;NP_057632.2,Golgi membrane protein 1","-","IPR026143,Golgi membrane protein 1;IPR026139,GOLM1/CASC4 family","ENOG4111ZGQ,-;ENOG410IKCK,-","GO:0005794,cellular_component,Golgi apparatus;GO:0019216,biological_process,regulation of lipid metabolic process;GO:0006997,biological_process,nucleus organization","-"]
["C11orf57",7.880953562,3.928545215,1.003274762,5.120443891,0.000544895,1.400575E-3,"ENSG00000150776","A0A024R3H5,Chromosome 11 open reading frame 57, isoform CRA_a","NP_001076438.1,-;NP_060665.3,uncharacterized protein NKAPD1 isoform a","PF15692,NF-kappa-B-activating protein","-","ENOG410IGQD,-;ENOG41126TE,-","-","-"]
["ADSL",7.947618419,3.962741707,1.00314091,5.431616061,0.000267487,0.000737227,"ENSG00000239900","A0A0A6YY92,Adenylosuccinate lyase","-","PF10397,Adenylosuccinate lyase C-terminus;PF00206,Lyase","IPR020557,Fumarate lyase, conserved site;IPR024083,Fumarase/histidase, N-terminal;IPR000362,Fumarate lyase family;IPR022761,Fumarate lyase, N-terminal;IPR008948,L-Aspartase-like;IPR019468,Adenylosuccinate lyase C-terminal;IPR004769,Adenylosuccinate lyase","COG0015,Adenylosuccinate lyase;KOG2700,Adenylosuccinate lyase","GO:0070626,molecular_function,(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity;GO:0006189,biological_process,'de novo' IMP biosynthetic process;GO:0006164,biological_process,purine nucleotide biosynthetic process;GO:0003824,molecular_function,catalytic activity;GO:0004018,molecular_function,N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0009152,biological_process,purine ribonucleotide biosynthetic process;GO:0005829,cellular_component,cytosol;GO:0044208,biological_process,'de novo' AMP biosynthetic process;GO:0016829,molecular_function,lyase activity","-"]
["PCMTD1",9.598279804,4.787653779,1.002747683,5.741289009,1.14503E-4,3.42064E-4,"ENSG00000168300","A0A091CU63,Protein-L-isoaspartate O-methyltransferase domain-containing protein 1","XP_010603848.1,protein-L-isoaspartate O-methyltransferase domain-containing protein 1","PF01135,Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)","IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR000682,Protein-L-isoaspartate(D-aspartate) O-methyltransferase","-","GO:0004719,molecular_function,protein-L-isoaspartate (D-aspartate) O-methyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0006479,biological_process,protein methylation;GO:0008168,molecular_function,methyltransferase activity;GO:0032259,biological_process,methylation;GO:0006464,biological_process,cellular protein modification process","-"]
["GMIP",4.571425257,2.277874217,1.002040314,3.76131485,0.00937491,0.01799075,"ENSG00000089639","A0A024R7N1,GEM interacting protein, isoform CRA_b","NP_057657.2,GEM-interacting protein isoform 1","PF00620,RhoGAP domain","IPR008936,Rho GTPase activation protein;IPR002219,Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;IPR000198,Rho GTPase-activating protein domain;IPR027267,AH/BAR domain superfamily;IPR031160,F-BAR domain","ENOG410IPS0,-;ENOG410XPZ9,-","GO:0035556,biological_process,intracellular signal transduction;GO:0046872,molecular_function,metal ion binding;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005886,cellular_component,plasma membrane;GO:0005096,molecular_function,GTPase activator activity;GO:0005829,cellular_component,cytosol;GO:0007165,biological_process,signal transduction;GO:0005654,cellular_component,nucleoplasm","-"]
["CYP1B1-AS1",2.29584134,1.143984097,1.002040314,3.76131485,0.00937491,0.01799075,"ENSG00000232973","D6W591,Uncharacterized protein","-","-","-","-","-","-"]
["CTBP1-AS",4.399673304,2.192292736,1.002040314,3.76131485,0.00937491,0.01799075,"ENSG00000280927","H0WU16,C-terminal binding protein 1","-","PF03446,NAD binding domain of 6-phosphogluconate dehydrogenase;PF00389,-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain;PF02826,-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain","IPR036291,NAD(P)-binding domain superfamily;IPR029752,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1;IPR029753,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site;IPR006140,D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain;IPR006139,D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain","KOG0067,Transcription factor CtBP;COG0111,Phosphoglycerate dehydrogenase and related dehydrogenases","GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0008134,molecular_function,transcription factor binding;GO:0031065,biological_process,positive regulation of histone deacetylation;GO:0005634,cellular_component,nucleus;GO:0051287,molecular_function,NAD binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0035067,biological_process,negative regulation of histone acetylation;GO:0090241,biological_process,negative regulation of histone H4 acetylation;GO:0050872,biological_process,white fat cell differentiation;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0016491,molecular_function,oxidoreductase activity;GO:0008152,biological_process,metabolic process;GO:0001106,molecular_function,RNA polymerase II transcription corepressor activity;GO:0005654,cellular_component,nucleoplasm;GO:0005667,cellular_component,transcription factor complex;GO:0016616,molecular_function,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0017053,cellular_component,transcriptional repressor complex;GO:0070491,molecular_function,repressing transcription factor binding;GO:0019904,molecular_function,protein domain specific binding;GO:1903758,biological_process,negative regulation of transcription from RNA polymerase II promoter by histone modification;GO:0051726,biological_process,regulation of cell cycle;GO:0055114,biological_process,oxidation-reduction process","-"]
["LARS",18.51592411,9.243031402,1.001997246,6.826664433,{"v":1.79e-05,"d":"1.79E-05"},{"v":6.42e-05,"d":"6.42E-05"},"ENSG00000133706","B2RCM2,cDNA, FLJ96156, highly similar to Homo sapiens leucyl-tRNA synthetase","-","PF08264,Anticodon-binding domain of tRNA;PF00133,tRNA synthetases class I (I, L, M and V)","IPR002300,Aminoacyl-tRNA synthetase, class Ia;IPR009008,Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain;IPR013155,Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding;IPR009080,Aminoacyl-tRNA synthetase, class Ia, anticodon-binding;IPR004493,Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic;IPR001412,Aminoacyl-tRNA synthetase, class I, conserved site","KOG0437,Leucyl-tRNA synthetase;COG0495,Leucyl-tRNA synthetase","GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0004823,molecular_function,leucine-tRNA ligase activity;GO:0002161,molecular_function,aminoacyl-tRNA editing activity;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0006429,biological_process,leucyl-tRNA aminoacylation;GO:0005524,molecular_function,ATP binding;GO:0016874,molecular_function,ligase activity;GO:0000166,molecular_function,nucleotide binding;GO:0006412,biological_process,translation;GO:0106074,biological_process,aminoacyl-tRNA metabolism involved in translational fidelity","-"]
["MYH9",107.293076,53.58041601,1.001727504,9.494818028,{"v":1.97e-06,"d":"1.97E-06"},{"v":8.78e-06,"d":"8.78E-06"},"ENSG00000100345","A0A024R1N1,Myosin, heavy polypeptide 9, non-muscle, isoform CRA_a","XP_011528499.1,-;XP_016884295.1,-;XP_016884293.1,-;XP_016884292.1,-;NP_002464.1,myosin-9;XP_016884294.1,-","PF01576,Myosin tail;PF00063,Myosin head (motor domain);PF02736,Myosin N-terminal SH3-like domain","IPR002928,Myosin tail;IPR001609,Myosin head, motor domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036305,RGS domain superfamily;IPR004009,Myosin, N-terminal, SH3-like;IPR000048,IQ motif, EF-hand binding site;IPR036961,Kinesin motor domain superfamily;IPR008989,Myosin S1 fragment, N-terminal;IPR027401,Myosin IQ motif-containing domain superfamily","COG5022,Myosin heavy chain;KOG0161,Myosin class II heavy chain","GO:0001725,cellular_component,stress fiber;GO:0098609,biological_process,cell-cell adhesion;GO:0030863,cellular_component,cortical cytoskeleton;GO:0005903,cellular_component,brush border;GO:0003774,molecular_function,motor activity;GO:0005886,cellular_component,plasma membrane;GO:0008017,molecular_function,microtubule binding;GO:0005925,cellular_component,focal adhesion;GO:0005524,molecular_function,ATP binding;GO:0008360,biological_process,regulation of cell shape;GO:0007155,biological_process,cell adhesion;GO:0016460,cellular_component,myosin II complex;GO:0000904,biological_process,cell morphogenesis involved in differentiation;GO:0005737,cellular_component,cytoplasm;GO:0005913,cellular_component,cell-cell adherens junction;GO:0005938,cellular_component,cell cortex;GO:0001931,cellular_component,uropod;GO:0001768,biological_process,establishment of T cell polarity;GO:0051015,molecular_function,actin filament binding;GO:0000212,biological_process,meiotic spindle organization;GO:0006911,biological_process,phagocytosis, engulfment;GO:0032796,biological_process,uropod organization;GO:0007520,biological_process,myoblast fusion;GO:0001772,cellular_component,immunological synapse;GO:0031594,cellular_component,neuromuscular junction;GO:0003779,molecular_function,actin binding;GO:1903919,biological_process,negative regulation of actin filament severing;GO:0007018,biological_process,microtubule-based movement;GO:0016459,cellular_component,myosin complex;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity;GO:1903923,biological_process,positive regulation of protein processing in phagocytic vesicle;GO:0005819,cellular_component,spindle;GO:0019904,molecular_function,protein domain specific binding;GO:0051295,biological_process,establishment of meiotic spindle localization;GO:0001701,biological_process,in utero embryonic development","K10352,ko04530,Tight junction"]
["PPFIBP2",3.209921897,1.601349893,1.001636444,4.580243628,1.514896E-3,0.003513078,"ENSG00000166387","H2Q340,Uncharacterized protein","XP_001164875.2,liprin-beta-2 isoform X15","PF00536,SAM domain (Sterile alpha motif);PF07647,SAM domain (Sterile alpha motif)","IPR037618,Liprin-beta, SAM domain repeat 2;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR037619,Liprin-beta, SAM domain repeat 3;IPR029515,LAR-interacting protein, Liprin;IPR030435,Liprin-beta-2;IPR001660,Sterile alpha motif domain;IPR037617,Liprin-beta, SAM domain repeat 1","ENOG410XSFF,-;KOG1899,LAR transmembrane tyrosine phosphatase-interacting protein liprin","GO:0042802,molecular_function,identical protein binding","-"]
["SEC22B",2.18166837,1.08810088,1.00109393,3.957042752,0.006043547,0.01216039,"ENSG00000265808","G3HP80,Vesicle-trafficking protein SEC22b","-","PF13774,Regulated-SNARE-like domain;PF00957,Synaptobrevin","IPR010908,Longin domain;IPR011012,Longin-like domain superfamily;IPR001388,Synaptobrevin","-","GO:1902902,biological_process,negative regulation of autophagosome assembly;GO:0045732,biological_process,positive regulation of protein catabolic process;GO:0005793,cellular_component,endoplasmic reticulum-Golgi intermediate compartment;GO:0000139,cellular_component,Golgi membrane;GO:0016020,cellular_component,membrane;GO:0016192,biological_process,vesicle-mediated transport;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0012507,cellular_component,ER to Golgi transport vesicle membrane;GO:0016021,cellular_component,integral component of membrane","-"]
["UBE2E2",6.019912052,3.002413974,1.00109393,3.957042752,0.006043547,0.01216039,"ENSG00000182247","A0A1S3ENU7,ubiquitin-conjugating enzyme E2 E2","XP_012866063.1,-","-","IPR016135,Ubiquitin-conjugating enzyme/RWD-like;IPR023313,Ubiquitin-conjugating enzyme, active site;IPR000608,Ubiquitin-conjugating enzyme E2","-","GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding","-"]
["AC068533.7",21.37656405,10.66150038,1.00109393,3.957042752,0.006043547,0.01216039,"ENSG00000249319","H7C0S8,Uncharacterized protein","-","PF03874,RNA polymerase Rpb4;PF14698,Argininosuccinate lyase C-terminal;PF00206,Lyase","IPR008948,L-Aspartase-like;IPR009049,Argininosuccinate lyase;IPR005574,RNA polymerase II, Rpb4;IPR010997,HRDC-like superfamily;IPR006590,RNA polymerase II, Rpb4, core;IPR000362,Fumarate lyase family;IPR022761,Fumarate lyase, N-terminal;IPR020557,Fumarate lyase, conserved site;IPR038324,Rpb4/RPC9 superfamily;IPR029419,Argininosuccinate lyase, C-terminal","COG0165,Argininosuccinate lyase;KOG4168,Predicted RNA polymerase III subunit C17;KOG1316,Argininosuccinate lyase","GO:0005737,cellular_component,cytoplasm;GO:0044237,biological_process,cellular metabolic process;GO:0003824,molecular_function,catalytic activity;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0042450,biological_process,arginine biosynthetic process via ornithine;GO:0006351,biological_process,transcription, DNA-templated;GO:0004056,molecular_function,argininosuccinate lyase activity;GO:0000166,molecular_function,nucleotide binding","-"]
["RP11-343C2.11",51.59764839,25.7741495,1.000630103,5.657918299,0.000149341,0.000436417,"ENSG00000260914","I3L4J1,Uncharacterized protein","-","PF09336,Vps4 C terminal oligomerisation domain;PF04212,MIT (microtubule interacting and transport) domain;PF00004,ATPase family associated with various cellular activities (AAA)","IPR007330,MIT;IPR003960,ATPase, AAA-type, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR015415,Vps4 oligomerisation, C-terminal;IPR036181,MIT domain superfamily;IPR003593,AAA+ ATPase domain;IPR003959,ATPase, AAA-type, core","ENOG410XRHN,-;KOG0739,AAA+-type ATPase","GO:0000166,molecular_function,nucleotide binding;GO:0016887,molecular_function,ATPase activity;GO:0005634,cellular_component,nucleus;GO:0005524,molecular_function,ATP binding","-"]
["GTPBP4",22.25735001,11.12252061,1.00045666,6.781186629,{"v":2.01e-05,"d":"2.01E-05"},{"v":7.16e-05,"d":"7.16E-05"},"ENSG00000107937","D2CFK9,Nucleolar GTP-binding protein 1","NP_036473.2,nucleolar GTP-binding protein 1","PF08155,NOGCT (NUC087) domain;PF06858,Nucleolar GTP-binding protein 1 (NOG1)","IPR010674,Nucleolar GTP-binding protein 1, Rossman-fold domain;IPR012973,NOG, C-terminal;IPR005225,Small GTP-binding protein domain;IPR031167,OBG-type guanine nucleotide-binding (G) domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR006073,GTP binding domain;IPR024926,Nucleolar GTP-binding protein 1","KOG1490,GTP-binding protein CRFG/NOG1 (ODN superfamily);COG1084,Predicted GTPase","GO:0042254,biological_process,ribosome biogenesis;GO:0005794,cellular_component,Golgi apparatus;GO:0005730,cellular_component,nucleolus;GO:0005525,molecular_function,GTP binding;GO:0031965,cellular_component,nuclear membrane;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0000463,biological_process,maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","K06943,ko03008,Ribosome biogenesis in eukaryotes"]
["FAM64A",7.906926552,3.946353926,1.000369118,4.129236154,4.871294E-3,0.01002221,"ENSG00000129195","I3L156,Protein PIMREG","-","PF07326,Protein of unknown function (DUF1466)","IPR009932,RCS1","-","GO:0005634,cellular_component,nucleus","-"]
["LLNLR-245B6.1",9.250415937,4.616890648,1.000369118,4.129236154,4.871294E-3,0.01002221,"ENSG00000283103","V9H0F2,Endogenous retrovirus HERV-K","-","PF00552,Integrase DNA binding domain","IPR036397,Ribonuclease H superfamily;IPR036862,Integrase, C-terminal domain superfamily, retroviral;IPR001037,Integrase, C-terminal, retroviral;IPR001584,Integrase, catalytic core;IPR012337,Ribonuclease H-like superfamily","-","GO:0003676,molecular_function,nucleic acid binding;GO:0015074,biological_process,DNA integration","-"]
["DZIP3",3.201556749,1.597899761,1.000369118,4.129236154,4.871294E-3,0.01002221,"ENSG00000198919","H2R422,DAZ interacting protein 3, zinc finger","XP_009444377.1,-;XP_001151742.1,E3 ubiquitin-protein ligase DZIP3 isoform X1;XP_009444375.1,-;XP_009444376.1,-","PF13639,Ring finger domain","IPR001841,Zinc finger, RING-type;IPR033103,E3 ubiquitin-protein ligase DZIP3;IPR013083,Zinc finger, RING/FYVE/PHD-type","ENOG410Y41H,-;ENOG410IFEY,-","GO:1990381,molecular_function,ubiquitin-specific protease binding;GO:0061630,molecular_function,ubiquitin protein ligase activity;GO:0030433,biological_process,ubiquitin-dependent ERAD pathway;GO:0000209,biological_process,protein polyubiquitination;GO:0005737,cellular_component,cytoplasm;GO:0000836,cellular_component,Hrd1p ubiquitin ligase complex;GO:0019902,molecular_function,phosphatase binding;GO:0003723,molecular_function,RNA binding;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0036513,cellular_component,Derlin-1 retrotranslocation complex;GO:1904264,-,-;GO:0044322,cellular_component,endoplasmic reticulum quality control compartment;GO:0031593,molecular_function,polyubiquitin modification-dependent protein binding;GO:0051082,molecular_function,unfolded protein binding","-"]