{"text_format":"3","workbook":"xls","n_sheets":2,"sheets":["Table 6","Table 7"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table 6","index":0,"n_rows":41,"n_cols":7,"rows_kept":41,"merged":[[0,0,0,5]],"flags":["formulas_cached_only"]}
["Table 6. Significant KEGG pathways of up-regulated DEGs "]
["ID","Term"," Significantly DEGs","All Genes","P_value","Q value","Gene included"]
["ko01200","Carbon metabolism","26/395","98/4515",{"v":1.42031657274731e-07,"d":"1.42E-07"},{"v":2.72102753936854e-05,"d":"2.72E-05"},"GAPDH(-1.65375570717),PFKM(-4.03680576849),TPI1(-1.42938645202),ACO2(-1.44308370586),HADHA(-1.47969426217),IDH2(-1.27649212428),PGAM1(-1.3011491092),CAT(-1.39849279317),MDH1(-1.27074311163),GOT1(-1.6276037084),IDH3A(-1.38435889505),OGDH(-1.03749820979),SDHA(-1.07611904255),FBP2(-3.4364571583),CS(-1.02261487199),ALDH6A1(-1.08539248124),SRRL(-2.17910544895),PDHA1(-1.01422516157),HK2(-1.27330540724),IDH3B(-1.0064109393),PCCA(-1.41105166399),ENO4(-3.3928212032),ACSS1L(-16.1131178505),PRPS2(-2.14470282846),RGN(-1.45056720973),SHMT1(-1.10007326699)"]
["ko04260","Cardiac muscle contraction","18/395","59/4515",{"v":1.37549894030763e-06,"d":"1.38E-06"},0.000131758319545257,"COX3(-1.09728066946),CYTB(-1.0992869079),TPM2(-1.48630025378),CACNA1S(-4.18664191722),MYL3(-9.59983810251),ATP1B4(-3.94525317314),MYL2(-6.12773888756),TNNC1(-6.40361050395),CACNG1(-2.84883022607),ACTC1(-4.25003305673),UQCRFS1(-1.02615625707),UQCR11(-1.62618209566),UQCR10(-1.19024348863),UQCRQ(-1.03036986939),UQCRB(-1.07362227036),MYH7B(-16.5068314796),CACNB1(-1.54064787033),TNNT2(-17.562246375)"]
["ko01230","Biosynthesis of amino acids","17/395","61/4515",{"v":1.06513457711325e-05,"d":"1.07E-05"},0.000680191203630218,"GAPDH(-1.65375570717),PFKM(-4.03680576849),TPI1(-1.42938645202),ACO2(-1.44308370586),IDH2(-1.27649212428),PGAM1(-1.3011491092),GOT1(-1.6276037084),IDH3A(-1.38435889505),CBS(-1.67228940401),CS(-1.02261487199),ASS1(-1.35007247905),SRRL(-2.17910544895),IDH3B(-1.0064109393),ASL2(-1.23136395673),ENO4(-3.3928212032),PRPS2(-2.14470282846),SHMT1(-1.10007326699)"]
["ko00190","Oxidative phosphorylation","25/395","116/4515",{"v":1.50842504200652e-05,"d":"1.51E-05"},0.000722456204329439,"COX3(-1.09728066946),CYTB(-1.0992869079),ND4(-1.02112603844),ATP12A(-5.70881567),NDUFS1(-1.21001372695),NDUFV1(-1.08760368976),SDHA(-1.07611904255),NDUFS7(-1.18783223091),UQCRFS1(-1.02615625707),UQCR11(-1.62618209566),NDUFV3(-1.34360593265),UQCR10(-1.19024348863),NDUFAB1(-1.36532100844),ATP5G1(-1.01391431081),UQCRQ(-1.03036986939),NDUFB6(-1.29430094445),ATP6V0A4(-5.71986860583),NDUFA5(-1.0828172044),UQCRB(-1.07362227036),NDUFS2(-1.09593948267),NDUFS8(-1.00581125322),ATP6V0A1(-1.0779205335),NDUFS6(-1.1497751454),ATP6V0D2(-3.66268307057),ATP6V1G3(-6.48761284726)"]
["ko00020","Citrate cycle (TCA cycle)","10/395","29/4515",0.000102715818945238,0.00393563769432282,"ACO2(-1.44308370586),IDH2(-1.27649212428),MDH1(-1.27074311163),IDH3A(-1.38435889505),OGDH(-1.03749820979),SDHA(-1.07611904255),CS(-1.02261487199),PDHA1(-1.01422516157),PDHX(-1.46788981913),IDH3B(-1.0064109393)"]
["ko04261","Adrenergic signaling in cardiomyocytes","23/395","123/4515",0.000325715946079327,0.0100508762892567,"TPM2(-1.48630025378),CACNA1S(-4.18664191722),MYL3(-9.59983810251),PLN(-5.08511692576),ATP1B4(-3.94525317314),MYL2(-6.12773888756),TNNC1(-6.40361050395),CACNG1(-2.84883022607),ACTC1(-4.25003305673),CAMK2A(-3.60983449788),PPP1R1A(-3.14635401982),PPP2R3B(-2.81193362704),PIK3R1(-2.42034324108),MYH7B(-16.5068314796),CACNB1(-1.54064787033),AGTR1(-1.27720981097),RAPGEF3(-1.00538158528),CREM(-1.20728979163),ADRB2(-1.19649444058),TNNT2(-17.562246375),KCNQ1(-1.11502213658),RAPGEF4(-1.20239841729),AGTR2(-1.22667348563)"]
["ko01210","2-Oxocarboxylic acid metabolism","6/395","13/4515",0.000435091797387498,0.0100508762892567,"ACO2(-1.44308370586),IDH2(-1.27649212428),GOT1(-1.6276037084),IDH3A(-1.38435889505),CS(-1.02261487199),IDH3B(-1.0064109393)"]
["ko04020","Calcium signaling pathway","28/395","166/4515",0.000455860814080546,0.0100508762892567,"TNNC2(-3.93940384926),SLC25A4(-3.16255607067),NOS2(-4.40710152699),CACNA1S(-4.18664191722),PLN(-5.08511692576),MYLK2(-3.31875119178),TNNC1(-6.40361050395),PHKG1(-2.31607270119),RYR3(-3.7142969435),MYLK4(-4.53176180626),HTR6(-2.89691962622),CAMK2A(-3.60983449788),ERBB4(-3.41221971048),P2RX5(-3.20124277406),SLC8A3(-2.50573135642),MYLK3(-1.95116260616),PHKA1(-1.07254121031),ORAI2(-1.02105242286),HRH1(-1.33368651928),AGTR1(-1.27720981097),PPIF(-1.49447670263),PHKA2(-1.54238256308),ADRB2(-1.19649444058),PLCD4(-1.0042109591),CAMK4(-3.56165728413),LOC107057170(-1.13472385229),OXTR(-2.58854783358),P2RX6(-1.27725044878)"]
["ko00010","Glycolysis / Gluconeogenesis","13/395","53/4515",0.000472170287215081,0.0100508762892567,"GAPDH(-1.65375570717),PFKM(-4.03680576849),TPI1(-1.42938645202),PGAM1(-1.3011491092),ALDH1A3(-1.35106942873),PGM1(-1.20173852809),FBP2(-3.4364571583),BPGM(-1.54218554722),PDHA1(-1.01422516157),HK2(-1.27330540724),PDHX(-1.46788981913),ENO4(-3.3928212032),ACSS1L(-16.1131178505)"]
["ko03320","PPAR signaling pathway","13/395","60/4515",0.00164736162338343,0.031559980574293,"APOA1(-2.15046976297),CD36(-2.65375462248),FABP4(-2.34327095821),FABP5(-2.3164542574),LPL(-3.45215780512),ACSL1(-1.40787609726),PLIN2(-1.37548487114),ACSBG2(-1.37124790582),SCD5(-1.83762648206),CYP27A1(-2.11067979874),PLIN1(-1.4619604153),ACSL5(-2.38399134497),ACSBG1(-2.47676963333)"]
["ko04145","Phagosome","21/395","127/4515",0.0029733136801514,0.0517840277308665,"LPO(-5.79065004609),SFTPA2(-14.7663964835),CD36(-2.65375462248),THBS1(-2.3320255236),COMP(-1.53321934835),BF2(-1.29962263795),BF1(-1.34377687282),C3(-2.36007288812),MRC2(-1.0265750956),ATP6V0A4(-5.71986860583),TUBA4A(-1.54063039074),DYNC2H1(-1.64539290962),ATP6V0A1(-1.0779205335),YF5(-5.15437957523),ATP6V0D2(-3.66268307057),TAP2(-1.77597327),SEC61A2(-1.11860113173),TUBA8A(-3.46647328165),TAP1(-1.78944335937),ATP6V1G3(-6.48761284726),THBS4(-1.54464211764)"]
["ko00061","Fatty acid biosynthesis","5/395","13/4515",0.00355908833451348,0.0548208791470747,"ACACB(-2.90224246306),ACSL1(-1.40787609726),ACSBG2(-1.37124790582),ACSL5(-2.38399134497),ACSBG1(-2.47676963333)"]
["ko00260","Glycine, serine and threonine metabolism","9/395","37/4515",0.00371998822783721,0.0548208791470747,"PGAM1(-1.3011491092),TDH(-2.44217978562),CBS(-1.67228940401),BHMT(-3.34925020722),BPGM(-1.54218554722),SRRL(-2.17910544895),GAMT(-2.77509572054),SHMT1(-1.10007326699),GRHPR(-1.18155918793)"]
["ko00982","Drug metabolism - cytochrome P450","8/395","31/4515",0.00416620493281068,0.0570112253963566,"AOX2(-3.5799647188),FMO3(-2.43919423639),ALDH1A3(-1.35106942873),GSTA4L(-2.29950517625),GSTT1(-2.1644257926),GSTA2(-1.44907323431),GSTAL2(-1.03367737864),GSTA3(-1.02610201372)"]
["ko04910","Insulin signaling pathway","19/395","119/4515",0.00682164078362136,0.0871255173767781,"IRS2(-3.27132786021),PHKG1(-2.31607270119),INSR(-1.79570673258),ACACB(-2.90224246306),PPP1R3A(-3.71405550835),FBP2(-3.4364571583),LOC107050456(-1.64444519462),SH2B2(-2.06249651098),HK2(-1.27330540724),PIK3R1(-2.42034324108),PHKA1(-1.07254121031),RAPGEF1(-1.04295567956),SOCS3(-1.91512332004),PRKAG2(-1.21333941972),PHKA2(-1.54238256308),LOC107051846(-1.1888534557),PDE3B(-1.34562289477),FOXO1(-1.02745564001),MKNK1(-1.26947766858)"]
["ko00630","Glyoxylate and dicarboxylate metabolism","7/395","28/4515",0.00872511511345187,0.104471773068963,"ACO2(-1.44308370586),CAT(-1.39849279317),MDH1(-1.27074311163),CS(-1.02261487199),PCCA(-1.41105166399),SHMT1(-1.10007326699),GRHPR(-1.18155918793)"]
["ko00680","Methane metabolism","6/395","22/4515",0.0095971807942367,0.1081539878979,"PFKM(-4.03680576849),PGAM1(-1.3011491092),FBP2(-3.4364571583),ENO4(-3.3928212032),ACSS1L(-16.1131178505),SHMT1(-1.10007326699)"]
["ko04530","Tight junction","17/395","107/4515",0.0107256819340617,0.109274418940777,"MYH1B(-2.96939248614),MYH1D(-4.6850721296),MYH1F(-3.47394771623),YBX3(-1.28387600829),MYH1G(-3.85139108035),MYL2(-6.12773888756),MYL10(-7.56932711275),MYLPF(-3.91899947157),MYL12A(-1.21945193804),MYH1C(-3.2062634754),MYH10(-1.4218701835),MRAS(-2.6031332449),MYH1E(-3.06420395524),PRKCQ(-2.48116749716),MYH1A(-1.11428863465),MYH7B(-16.5068314796),CLDN11(-1.9210359637)"]
["ko04922","Glucagon signaling pathway","13/395","74/4515",0.0108460218870204,0.109274418940777,"PHKG1(-2.31607270119),PGAM1(-1.3011491092),ACACB(-2.90224246306),PFKFB4(-3.61918479087),CAMK2A(-3.60983449788),LOC107050456(-1.64444519462),PDHA1(-1.01422516157),PHKA1(-1.07254121031),PRKAG2(-1.21333941972),PHKA2(-1.54238256308),PDE3B(-1.34562289477),FOXO1(-1.02745564001),GCGR(-1.26790046436)"]
["ko04022","cGMP - PKG signaling pathway","21/395","143/4515",0.0119064429743742,0.109274418940777,"SLC25A4(-3.16255607067),CACNA1S(-4.18664191722),PLN(-5.08511692576),ATP1B4(-3.94525317314),IRS2(-3.27132786021),MYLK2(-3.31875119178),INSR(-1.79570673258),MYLK4(-4.53176180626),NFATC1(-2.28581905743),SLC8A3(-2.50573135642),MYLK3(-1.95116260616),PIK3R1(-2.42034324108),MEF2D(-1.08305630384),CNGB1(-4.5209496316),NPR2(-1.08599261387),AGTR1(-1.27720981097),PPIF(-1.49447670263),LOC107051846(-1.1888534557),ADRB2(-1.19649444058),PDE3B(-1.34562289477),LOC107057170(-1.13472385229)"]
["ko00220","Arginine biosynthesis","5/395","17/4515",0.0127700619345711,0.109274418940777,"NOS2(-4.40710152699),GOT1(-1.6276037084),ASS1(-1.35007247905),ASL2(-1.23136395673),LOC107057170(-1.13472385229)"]
["ko00710","Carbon fixation in photosynthetic organisms","5/395","17/4515",0.0127700619345711,0.109274418940777,"GAPDH(-1.65375570717),TPI1(-1.42938645202),MDH1(-1.27074311163),GOT1(-1.6276037084),FBP2(-3.4364571583)"]
["ko04213","Longevity regulating pathway - multiple species","10/395","52/4515",0.0131189343618461,0.109274418940777,"IRS2(-3.27132786021),HSPA8(-1.08797108255),FOXO3(-1.94846944982),INSR(-1.79570673258),CAT(-1.39849279317),CRYAB(-3.71069183987),PIK3R1(-2.42034324108),PRKAG2(-1.21333941972),LOC107051846(-1.1888534557),FOXO1(-1.02745564001)"]
["ko04514","Cell adhesion molecules (CAMs)","17/395","111/4515",0.0152365758789889,0.118239860455855,"SDC2(-2.75439257845),PECAM1(-1.15973521),BF2(-1.29962263795),CADM1(-3.16059182033),CDH15(-3.77192500692),BF1(-1.34377687282),ITGB8(-1.75437603354),NRXN1(-1.26945659669),NFASC(-2.42165319529),VCAM1(-1.51280832162),MPZL1(-1.54089585698),MPZ(-1.33484058185),YF5(-5.15437957523),SELE(-1.86462053302),NCAM1(-1.1380141532),CLDN11(-1.9210359637),CDH4(-1.56148478747)"]
["ko04974","Protein digestion and absorption","7/395","31/4515",0.0154296521199262,0.118239860455855,"COL2A1(-8.89230320337),COL9A1(-8.70903818525),COL9A2(-9.04045211605),COL9A3(-8.32630202466),ATP1B4(-3.94525317314),SLC8A3(-2.50573135642),KCNQ1(-1.11502213658)"]
["ko00750","Vitamin B6 metabolism","3/395","7/4515",0.0178090300040931,0.131224431609107,"AOX2(-3.5799647188),PDXK(-1.16082216885),PNPO(-1.43048012436)"]
["ko04920","Adipocytokine signaling pathway","11/395","63/4515",0.0191967095381075,0.133174143783268,"CD36(-2.65375462248),IRS2(-3.27132786021),ACACB(-2.90224246306),ACSL1(-1.40787609726),PRKCQ(-2.48116749716),ACSBG2(-1.37124790582),SOCS3(-1.91512332004),PRKAG2(-1.21333941972),LOC107051846(-1.1888534557),ACSL5(-2.38399134497),ACSBG1(-2.47676963333)"]
["ko02010","ABC transporters","8/395","40/4515",0.020300951473713,0.133174143783268,"ABCC5(-2.421343169),ABCG1(-2.79434701064),ABCB6(-2.28681334675),ABCA9(-1.52929789439),ABCC9(-1.49332761048),TAP2(-1.77597327),CFTR(-1.5588478169),TAP1(-1.78944335937)"]
["ko04923","Regulation of lipolysis in adipocyte","9/395","48/4515",0.0212937254423821,0.133174143783268,"PNPLA2(-2.3016348771),IRS2(-3.27132786021),FABP4(-2.34327095821),INSR(-1.79570673258),PIK3R1(-2.42034324108),PLIN1(-1.4619604153),LOC107051846(-1.1888534557),ADRB2(-1.19649444058),PDE3B(-1.34562289477)"]
["ko00250","Alanine, aspartate and glutamate metabolism","7/395","33/4515",0.0215493326066882,0.133174143783268,"ADSL(-2.05120059675),GFPT2(-1.91575473236),GOT1(-1.6276037084),ADSSL1(-1.52659709676),ASS1(-1.35007247905),ASL2(-1.23136395673),FOLH1(-1.31422799834)"]
["ko00620","Pyruvate metabolism","7/395","33/4515",0.0215493326066882,0.133174143783268,"MDH1(-1.27074311163),ACACB(-2.90224246306),ACYP2(-1.80000992849),PDHA1(-1.01422516157),PDHX(-1.46788981913),ACSS1L(-16.1131178505),GRHPR(-1.18155918793)"]
["ko00051","Fructose and mannose metabolism","7/395","34/4515",0.0251651930635289,0.146094581740423,"PFKM(-4.03680576849),TPI1(-1.42938645202),AKR1B10L1(-1.46423236207),PFKFB4(-3.61918479087),AKR1B1L(-1.73289824712),FBP2(-3.4364571583),HK2(-1.27330540724)"]
["ko00980","Metabolism of xenobiotics by cytochrome P450","7/395","34/4515",0.0251651930635289,0.146094581740423,"ALDH1A3(-1.35106942873),GSTA4L(-2.29950517625),GSTT1(-2.1644257926),GSTA2(-1.44907323431),GSTAL2(-1.03367737864),HSD11B1a(-1.02023602582),GSTA3(-1.02610201372)"]
["ko04152","AMPK signaling pathway","15/395","100/4515",0.0259911701221724,0.146451794496451,"PFKM(-4.03680576849),CD36(-2.65375462248),IRS2(-3.27132786021),FOXO3(-1.94846944982),INSR(-1.79570673258),PFKFB4(-3.61918479087),FBP2(-3.4364571583),LOC107050456(-1.64444519462),SCD5(-1.83762648206),PPP2R3B(-2.81193362704),PIK3R1(-2.42034324108),PRKAG2(-1.21333941972),LOC107051846(-1.1888534557),CFTR(-1.5588478169),FOXO1(-1.02745564001)"]
["ko04066","HIF-1 signaling pathway","13/395","83/4515",0.0267710205370483,0.146536112413317,"GAPDH(-1.65375570717),TF(-4.51231054381),NOS2(-4.40710152699),INSR(-1.79570673258),VEGFRKDRL(-1.31477997914),CAMK2A(-3.60983449788),PDHA1(-1.01422516157),HK2(-1.27330540724),PIK3R1(-2.42034324108),ENO4(-3.3928212032),IL6R(-1.05678862444),LOC107057170(-1.13472385229),MKNK1(-1.26947766858)"]
["ko00140","Steroid hormone biosynthesis","7/395","35/4515",0.0291757007060741,0.155262500833494,"RP11-400G3.5(-1.72509979612),CYP2C45(-1.69342429247),AKR1D1(-3.76323923146),COMT(-1.38211311574),CYP11A1(-3.30619257594),SRD5A2(-1.72958373436),HSD11B1a(-1.02023602582)"]
["ko04510","Focal adhesion","24/395","188/4515",0.0365045571417036,0.185908063109257,"COL2A1(-8.89230320337),COL9A1(-8.70903818525),COL9A2(-9.04045211605),CHAD(-3.81960556308),COL9A3(-8.32630202466),THBS1(-2.3320255236),MYLK2(-3.31875119178),MYL2(-6.12773888756),COMP(-1.53321934835),MYL10(-7.56932711275),TNC(-3.63072971743),VEGFRKDRL(-1.31477997914),MYLK4(-4.53176180626),MYLPF(-3.91899947157),MYL12A(-1.21945193804),LAMA2(-1.30543192587),ITGB8(-1.75437603354),MYLK3(-1.95116260616),PIK3R1(-2.42034324108),RAPGEF1(-1.04295567956),CAV3(-3.09421319823),FLNB(-1.08782035803),PDGFC(-1.09825897741),THBS4(-1.54464211764)"]
["ko04512","ECM-receptor interaction","12/395","78/4515",0.0368751707595834,0.185908063109257,"COL2A1(-8.89230320337),COL9A1(-8.70903818525),COL9A2(-9.04045211605),CHAD(-3.81960556308),COL9A3(-8.32630202466),CD36(-2.65375462248),THBS1(-2.3320255236),COMP(-1.53321934835),TNC(-3.63072971743),LAMA2(-1.30543192587),ITGB8(-1.75437603354),THBS4(-1.54464211764)"]
["ko01212","Fatty acid metabolism","8/395","45/4515",0.0388611204297872,0.190896731935797,"HADHA(-1.47969426217),ACSL1(-1.40787609726),ACSBG2(-1.37124790582),HACD1(-1.49231709419),ACADSB(-1.23688404653),SCD5(-1.83762648206),ACSL5(-2.38399134497),ACSBG1(-2.47676963333)"]

{"sheet":"Table 7","index":1,"n_rows":44,"n_cols":7,"rows_kept":44,"merged":[[0,0,0,6]],"flags":["formulas_cached_only"]}
["Table 7. Significant KEGG pathway of down-regulated DEGs "]
["ID","Term"," Significantly DEGs","All Genes","P_value","Q value","Gene included"]
["ko00100","Steroid biosynthesis","11/432","17/4515",{"v":3.96349830274548e-08,"d":"3.96E-08"},{"v":7.50978625783354e-06,"d":"7.51E-06"},"MSMO1(2.57744691913),FDFT1(1.97926714956),CYP51A1(1.64716039361),LSS(2.1664866997),SQLE(2.5187966562),DHCR24(2.35892439228),SC5D(1.3356167742),DHCR7(1.52864330482),LIPML5(3.50995801535),HSD17B7(1.91794043054),NSDHL(1.91461011924)"]
["ko04115","p53 signaling pathway","16/432","60/4515",0.000105863667522512,0.00767410146554209,"SFN(6.15507026697),PERP2(2.9172925497),SERPINB5(3.04920445422),PERP1(4.35282642741),CDKN1A(2.88022759968),CCNG2(1.33597607685),GADD45A(1.90366913709),RRM2(3.72384264476),LOC100858796(1.2727872627),ATR(1.00408290723),BID(1.05542031804),TP53I3(1.92810566954),CDK1(1.10794122357),CDK2(1.14025445353),CCND1(1.24584947051),PMAIP1(1.04062203278)"]
["ko04510","Focal adhesion","34/432","188/4515",0.00016062986108867,0.00767410146554209,"MYLK(4.50543065787),ACTB(1.92145608769),PPP1R12A(3.22551160413),MYL9(2.83642875646),COL1A1(1.53544826538),COL4A5(1.72792550253),COL1A2(1.24933582133),ACTN1(2.2011208288),COL4A6(1.77027765266),FLNA(3.31045735255),COL6A6(6.845675385),PPP1R12B(2.13797555244),ACTG1(2.17277026221),COL6A3(1.00799413328),VCL(1.034843191),ROCK1(1.11069363536),VAV3(1.99688923227),ITGA3(1.58330176983),ITGB5(1.20422613494),ITGA1(1.68851293553),VTN(1.88337288702),ITGAV(1.39255186695),PAK6(1.66933856585),ZYX(1.01482301602),LAMC2(2.08732993313),LAMB3(2.0341791077),GRB2(1.03492185902),ITGA11(1.52389651708),PIK3CD(1.35633899284),PAK4(1.08730917259),VASP(1.30573410203),ITGB3(1.40929479449),CCND1(1.24584947051),PAK5(1.00519728559)"]
["ko04921","Oxytocin signaling pathway","26/432","129/4515",0.000162008808717,0.00767410146554209,"MYLK(4.50543065787),ACTB(1.92145608769),PPP1R12A(3.22551160413),MYL9(2.83642875646),MYL6(2.58632202276),CDKN1A(2.88022759968),PPP1R12B(2.13797555244),CALML3(3.12516519318),ACTG1(2.17277026221),RYR2(4.46052172277),CACNA1C(2.69342627954),PPP3R1(1.20238585621),ROCK1(1.11069363536),CACNB2(3.05183936714),GUCY1A3(1.962166581),PRKAA2(1.79417197415),ITPR1(1.19371825273),GNAI3(1.07490060304),ADCY8(16.2655676175),PPP3CB(1.31564067791),PIK3CD(1.35633899284),CACNG3(15.658352922),ADCY7(1.21035262862),CACNB4(1.11527147587),CCND1(1.24584947051),CD38(1.35287991572)"]
["ko04512","ECM-receptor interaction","18/432","78/4515",0.000296234038142695,0.0094634005008101,"COL1A1(1.53544826538),COL4A5(1.72792550253),COL1A2(1.24933582133),COL4A6(1.77027765266),COL6A6(6.845675385),COL6A3(1.00799413328),SDC1(1.42124147894),CD44(1.17012799187),ITGA3(1.58330176983),ITGB5(1.20422613494),ITGA1(1.68851293553),SDC4(1.15366633854),VTN(1.88337288702),ITGAV(1.39255186695),LAMC2(2.08732993313),LAMB3(2.0341791077),ITGA11(1.52389651708),ITGB3(1.40929479449)"]
["ko00983","Drug metabolism - other enzymes","10/432","30/4515",0.00029967434919232,0.0094634005008101,"CES1L1(2.15734822687),LOC769704(1.95792256922),CES1L2(1.57662741699),UGT2A1(1.42720368068),LOC415787(2.38161624014),PNAT3(1.524115628),UGT1A1(1.19601852337),NAT(1.67027755254),TK1(1.7357453056),CDA(1.02191536049)"]
["ko04022","cGMP - PKG signaling pathway","27/432","143/4515",0.000374999230454685,0.0101503551100516,"MYLK(4.50543065787),PPP1R12A(3.22551160413),MYL9(2.83642875646),PDE5A(2.56005957379),ATP2B4(2.02513533156),MRVI1(2.81129596328),KCNMB1(4.77040589081),SLC8A1(3.61290039431),CALML3(3.12516519318),CREB3L1(1.97096098275),ATP1B3(1.30633831058),CACNA1C(2.69342627954),PPP3R1(1.20238585621),ROCK1(1.11069363536),ADORA1(4.99017267966),KCNMA1(2.05579148917),GUCY1A3(1.962166581),SLC25A5(1.0032060729),PRKG2(5.56712583941),ITPR1(1.19371825273),GNAI3(1.07490060304),ADCY8(16.2655676175),PPP3CB(1.31564067791),PIK3CD(1.35633899284),PRKCE(1.31687433182),VASP(1.30573410203),ADCY7(1.21035262862)"]
["ko00710","Carbon fixation in photosynthetic organisms","7/432","17/4515",0.000580541699718331,0.0137496718354342,"ALDOB(5.70813841305),ALDOC(1.99708781236),TKT(1.78746293827),RPIA(1.68359504561),FBP1(4.09039485177),GPT2(1.12547996524),ME1(1.02460361181)"]
["ko00900","Terpenoid backbone biosynthesis","7/432","19/4515",0.00126943270871064,0.0267248991307502,"ACAT2(1.91340125714),IDI1(1.94982095674),FDPS(1.42832838709),HMGCR(1.00155373159),MVD(1.32429321397),MVK(1.19143985471),PMVK(1.12858010761)"]
["ko00030","Pentose phosphate pathway","8/432","25/4515",0.00164395334341836,0.0311485896647689,"ALDOB(5.70813841305),ALDOC(1.99708781236),PGD(1.52540088205),TKT(1.78746293827),RPIA(1.68359504561),GPI(1.16822075081),FBP1(4.09039485177),TALDO1(1.04956631269)"]
["ko04974","Protein digestion and absorption","9/432","31/4515",0.00183341196413151,0.0315803017745141,"COL3A1(2.51104387788),COL1A1(1.53544826538),COL4A5(1.72792550253),COL1A2(1.24933582133),COL4A6(1.77027765266),COL6A6(6.845675385),SLC8A1(3.61290039431),COL6A3(1.00799413328),ATP1B3(1.30633831058)"]
["ko04924","Renin secretion","12/432","50/4515",0.00209293592029827,0.0330463566362885,"CALML3(3.12516519318),CACNA1C(2.69342627954),PPP3R1(1.20238585621),ADORA1(4.99017267966),KCNMA1(2.05579148917),ADCYAP1R1(1.76818786018),GUCY1A3(1.962166581),PRKG2(5.56712583941),ITPR1(1.19371825273),GNAI3(1.07490060304),PPP3CB(1.31564067791),PTGER4(1.00357904496)"]
["ko04530","Tight junction","20/432","107/4515",0.00240102417253689,0.0342270059165247,"MYH11(5.88344763736),ACTB(1.92145608769),MYL9(2.83642875646),ACTN1(2.2011208288),CLDN10(4.04351125792),ACTG1(2.17277026221),PPP2R2B(2.08831336367),PRKCI(1.75870497751),MPP5(1.35694627886),PARD6G(1.75828394412),PARD3(1.15278937622),GNAI3(1.07490060304),PATJ(1.29988782877),TJP3(1.07069171744),YES1(1.24899429283),PRKCH(1.62404977911),PRKCE(1.31687433182),PARD6B(1.09413860703),IGSF5(1.08117456863),CLDN25(1.2316006457)"]
["ko04270","Vascular smooth muscle contraction","21/432","115/4515",0.00254260158189833,0.0342270059165247,"ACTG2(6.87531198625),MYLK(4.50543065787),CALD1(2.81029536688),PPP1R12A(3.22551160413),MYL9(2.83642875646),MYL6(2.58632202276),MRVI1(2.81129596328),PPP1R12B(2.13797555244),KCNMB1(4.77040589081),CALML3(3.12516519318),CACNA1C(2.69342627954),ROCK1(1.11069363536),KCNMA1(2.05579148917),GUCY1A3(1.962166581),ITPR1(1.19371825273),PRKCH(1.62404977911),ADCY8(16.2655676175),PRKCE(1.31687433182),RAMP3(2.08519086357),ADCY7(1.21035262862),NPPC(16.7698659887)"]
["ko04360","Axon guidance","17/432","86/4515",0.00270963796839154,0.0342270059165247,"WNT5A(1.29181712423),PPP3R1(1.20238585621),ABL1(1.34112661424),ROCK1(1.11069363536),NCK2(1.59842695143),PARD6G(1.75828394412),PAK6(1.66933856585),WNT4(1.9301470629),GNAI3(1.07490060304),PPP3CB(1.31564067791),PIK3CD(1.35633899284),EFNA2(4.3844579461),PAK4(1.08730917259),PTCH1(1.4667922832),PARD6B(1.09413860703),PAK5(1.00519728559),SHH(1.49375817289)"]
["ko04970","Salivary secretion","12/432","52/4515",0.00298281734215456,0.0353228369465672,"ATP2B4(2.02513533156),CALML3(3.12516519318),ATP1B3(1.30633831058),KCNMA1(2.05579148917),GUCY1A3(1.962166581),PRKG2(5.56712583941),BST1(1.65171114079),ITPR1(1.19371825273),ADCY8(16.2655676175),ADCY7(1.21035262862),CHRM3(1.38188573382),CD38(1.35287991572)"]
["ko04713","Circadian entrainment","15/432","76/4515",0.00480199203455214,0.0516747061274824,"CALML3(3.12516519318),RYR2(4.46052172277),CACNA1C(2.69342627954),ADCYAP1R1(1.76818786018),GUCY1A3(1.962166581),PRKG2(5.56712583941),RPS6KA5(1.3539572607),ITPR1(1.19371825273),GNG4(4.07562674178),GNAI3(1.07490060304),GNG2(2.10288539908),ADCY8(16.2655676175),GNG10(1.16136628996),ADCY7(1.21035262862),GNB5(1.20322595889)"]
["ko04520","Adherens junction","14/432","69/4515",0.00490909708211082,0.0516747061274824,"ACTB(1.92145608769),CDH1(2.12837560319),ACTN1(2.2011208288),CTNND1(1.27382546586),ACTG1(2.17277026221),VCL(1.034843191),SORBS1(1.06638578781),WASL(1.25893127884),BAIAP2(1.6546533934),LOC101750739(2.44268053359),NECTIN1(1.53955620813),PARD3(1.15278937622),YES1(1.24899429283),SNAI2(1.08094865915)"]
["ko04391","Hippo signaling pathway -fly","9/432","36/4515",0.00556223961867615,0.0537038175839398,"ACTB(1.92145608769),ACTG1(2.17277026221),PPP2R2B(2.08831336367),PRKCI(1.75870497751),MPP5(1.35694627886),PARD6G(1.75828394412),PARD3(1.15278937622),NF2L(1.38890989165),PARD6B(1.09413860703)"]
["ko04810","Regulation of actin cytoskeleton","28/432","179/4515",0.00566873630052698,0.0537038175839398,"MYLK(4.50543065787),ACTB(1.92145608769),PPP1R12A(3.22551160413),MYL9(2.83642875646),SCIN(2.31668153315),ACTN1(2.2011208288),PPP1R12B(2.13797555244),ACTG1(2.17277026221),VCL(1.034843191),TIAM1(2.10268638331),WASL(1.25893127884),ROCK1(1.11069363536),VAV3(1.99688923227),ITGA3(1.58330176983),BAIAP2(1.6546533934),ITGB5(1.20422613494),IQGAP2(1.2279712927),ITGA1(1.68851293553),ITGAV(1.39255186695),PAK6(1.66933856585),APC(1.64351433777),FGF22(4.02510706408),ITGA11(1.52389651708),PIK3CD(1.35633899284),PAK4(1.08730917259),ITGB3(1.40929479449),CHRM3(1.38188573382),PAK5(1.00519728559)"]
["ko04390","Hippo signaling pathway","21/432","124/4515",0.00637645327969053,0.0575319092904409,"ACTB(1.92145608769),CDH1(2.12837560319),ACTG1(2.17277026221),WNT5A(1.29181712423),PPP2R2B(2.08831336367),PRKCI(1.75870497751),FZD4(1.12187959533),MPP5(1.35694627886),WNT10A(4.51526219384),PARD6G(1.75828394412),PARD3(1.15278937622),APC(1.64351433777),WNT4(1.9301470629),PATJ(1.29988782877),FZD7(1.43620485191),SNAI2(1.08094865915),WNT6(5.1776144136),BIRC5(2.41565126213),NF2L(1.38890989165),PARD6B(1.09413860703),CCND1(1.24584947051)"]
["ko00360","Phenylalanine metabolism","5/432","14/4515",0.00755784979273966,0.0650915293154612,"IL4I1(8.97855708565),ALDH3B1L1(3.99600053462),MIF(1.56487172379),AOC3(1.03493941141),MAOB(1.08459812611)"]
["ko00909","Sesquiterpenoid and triterpenoid biosynthesis","2/432","2/4515",0.00913569743154188,0.0752597500081254,"FDFT1(1.97926714956),SQLE(2.5187966562)"]
["ko04611","Platelet activation","18/432","106/4515",0.0108364535929572,0.0837004176784861,"COL3A1(2.51104387788),MYLK(4.50543065787),ACTB(1.92145608769),PPP1R12A(3.22551160413),COL1A1(1.53544826538),COL1A2(1.24933582133),ACTG1(2.17277026221),PRKCI(1.75870497751),ROCK1(1.11069363536),GUCY1A3(1.962166581),PRKG2(5.56712583941),ITPR1(1.19371825273),GNAI3(1.07490060304),ADCY8(16.2655676175),PIK3CD(1.35633899284),VASP(1.30573410203),ITGB3(1.40929479449),ADCY7(1.21035262862)"]
["ko04724","Glutamatergic synapse","15/432","83/4515",0.0110438051103558,0.0837004176784861,"GSL(2.82203361286),HOMER2(2.61260249517),CACNA1C(2.69342627954),PPP3R1(1.20238585621),PLD1(1.34395229016),ITPR1(1.19371825273),GNG4(4.07562674178),GNAI3(1.07490060304),GNG2(2.10288539908),ADCY8(16.2655676175),GRIN3B(1.36571184733),GNG10(1.16136628996),PPP3CB(1.31564067791),ADCY7(1.21035262862),GNB5(1.20322595889)"]
["ko00051","Fructose and mannose metabolism","8/432","34/4515",0.0128253485799568,0.0934640787203327,"AKR1B10L2(2.53626339611),ALDOB(5.70813841305),ALDOC(1.99708781236),GMDS(2.65987768624),FBP1(4.09039485177),PFKFB4L(1.38273931281),TSTA3(1.24459399077),PFKFB2(1.09188469107)"]
["ko04015","Rap1 signaling pathway","25/432","166/4515",0.0139077328484855,0.0975981252525299,"ACTB(1.92145608769),CDH1(2.12837560319),CTNND1(1.27382546586),CALML3(3.12516519318),ACTG1(2.17277026221),TIAM1(2.10268638331),PRKCI(1.75870497751),PARD6G(1.75828394412),PARD3(1.15278937622),GNAI3(1.07490060304),FGF22(4.02510706408),KIT(1.93015029938),LPAR2(1.04774820475),ADCY8(16.2655676175),CNR1(1.57545379407),PIK3CD(1.35633899284),EFNA2(4.3844579461),RASSF5(1.91870389125),VASP(1.30573410203),ITGB3(1.40929479449),ADCY7(1.21035262862),NGFR(1.93271173702),PARD6B(1.09413860703),LPAR5(1.47479887566),MAP2K6(2.04075688039)"]
["ko04540","Gap junction","14/432","82/4515",0.0221576915611796,0.149939266203471,"TUBB6(1.87828899043),TUBA3E(3.00453067298),GUCY1A3(1.962166581),PRKG2(5.56712583941),TUBA1C(1.0544405411),ITPR1(1.19371825273),GJA1(1.72104372648),GNAI3(1.07490060304),GRB2(1.03492185902),ADCY8(16.2655676175),HTR2B(2.73471677074),TUBB3(3.62964342644),ADCY7(1.21035262862),CDK1(1.10794122357)"]
["ko00633","Nitrotoluene degradation","2/432","3/4515",0.025666188285956,0.167691974282108,"PNAT3(1.524115628),NAT(1.67027755254)"]
["ko04152","AMPK signaling pathway","16/432","100/4515",0.0266670043149916,0.168423185147315,"ADIPOQ(1.51351080246),PPP2R5E(1.87447468504),CREB3L1(1.97096098275),FBP1(4.09039485177),CAB39L(1.48277796171),PPP2R2B(2.08831336367),PFKFB4L(1.38273931281),PRKAA2(1.79417197415),PPARG(1.78944682822),PCK1(4.84069786672),PFKFB2(1.09188469107),PIK3CD(1.35633899284),HMGCR(1.00155373159),CCNA2(1.24747949615),CCND1(1.24584947051),SCD(1.49787783375)"]
["ko04114","Oocyte meiosis","15/432","93/4515",0.0293169997360022,0.170409197316699,"PPP2R5E(1.87447468504),CALML3(3.12516519318),RPS6KA1L(1.88507706879),PPP3R1(1.20238585621),CPEB2(1.7360780155),CDC20(3.39262926773),ITPR1(1.19371825273),ADCY8(16.2655676175),PPP3CB(1.31564067791),PLK1(2.44597700766),MAD2L1(1.90104313888),ADCY7(1.21035262862),AURKA(2.34976022301),CDK1(1.10794122357),CDK2(1.14025445353)"]
["ko00040","Pentose and glucuronate interconversions","5/432","19/4515",0.0294487017853444,0.170409197316699,"AKR1B10L2(2.53626339611),UGT2A1(1.42720368068),DHDH(2.71908891516),UGT1A1(1.19601852337),XYLB(1.40358487268)"]
["ko04151","PI3K-Akt signaling pathway","37/432","284/4515",0.0296796018659918,0.170409197316699,"COL1A1(1.53544826538),COL4A5(1.72792550253),COL1A2(1.24933582133),COL4A6(1.77027765266),COL6A6(6.845675385),PPP2R5E(1.87447468504),CDKN1A(2.88022759968),COL6A3(1.00799413328),CREB3L1(1.97096098275),PPP2R2B(2.08831336367),ITGA3(1.58330176983),ITGB5(1.20422613494),ITGA1(1.68851293553),PRKAA2(1.79417197415),LPAR6(2.44284612094),VTN(1.88337288702),ITGAV(1.39255186695),GNG4(4.07562674178),LAMC2(2.08732993313),LAMB3(2.0341791077),FGF22(4.02510706408),KIT(1.93015029938),GNG2(2.10288539908),PCK1(4.84069786672),LPAR2(1.04774820475),GRB2(1.03492185902),PRLR(1.01327451166),ITGA11(1.52389651708),GNG10(1.16136628996),PIK3CD(1.35633899284),EFNA2(4.3844579461),ITGB3(1.40929479449),NGFR(1.93271173702),GNB5(1.20322595889),CDK2(1.14025445353),CCND1(1.24584947051),LPAR5(1.47479887566)"]
["ko00250","Alanine, aspartate and glutamate metabolism","7/432","33/4515",0.0333636337739206,0.180899073469809,"GSL(2.82203361286),IL4I1(8.97855708565),GFPT1(1.4181203606),GPT2(1.12547996524),CAD(1.08675960271),AGXT(15.9504704646),DDO(1.19048283379)"]
["ko04911","Insulin secretion","10/432","55/4515",0.0334160788492841,0.180899073469809,"KCNMB1(4.77040589081),RYR2(4.46052172277),CREB3L1(1.97096098275),ATP1B3(1.30633831058),CACNA1C(2.69342627954),KCNMA1(2.05579148917),ADCYAP1R1(1.76818786018),ADCY8(16.2655676175),ADCY7(1.21035262862),CHRM3(1.38188573382)"]
["ko04919","Thyroid hormone signaling pathway","12/432","71/4515",0.0351781618743852,0.184544043422498,"ACTB(1.92145608769),ACTG1(2.17277026221),ATP1B3(1.30633831058),PLCD3(1.68124218593),NOTCH1(1.08251580558),ITGAV(1.39255186695),WNT4(1.9301470629),HDAC1(1.04140671595),PFKFB2(1.09188469107),PIK3CD(1.35633899284),ITGB3(1.40929479449),CCND1(1.24584947051)"]
["ko04110","Cell cycle","17/432","112/4515",0.0360373507016711,0.184544043422498,"SFN(6.15507026697),CDKN1A(2.88022759968),ABL1(1.34112661424),GADD45A(1.90366913709),CDC20(3.39262926773),HDAC1(1.04140671595),CDKN2B(17.4988460129),MCM3(2.42331940657),PLK1(2.44597700766),ATR(1.00408290723),MAD2L1(1.90104313888),MCM5(1.73997704268),CDK1(1.10794122357),BUB1B(1.19979710207),CDK2(1.14025445353),CCNA2(1.24747949615),CCND1(1.24584947051)"]
["ko04670","Leukocyte transendothelial migration","15/432","97/4515",0.040865904619615,0.200936331434533,"ACTB(1.92145608769),MYL9(2.83642875646),ACTN1(2.2011208288),CLDN10(4.04351125792),CTNND1(1.27382546586),ACTG1(2.17277026221),VCL(1.034843191),ROCK1(1.11069363536),VAV3(1.99688923227),GNAI3(1.07490060304),PIK3CD(1.35633899284),RASSF5(1.91870389125),VASP(1.30573410203),NOX1(1.68937002684),CLDN25(1.2316006457)"]
["ko04261","Adrenergic signaling in cardiomyocytes","18/432","123/4515",0.0433577679244988,0.200936331434533,"ATP2B4(2.02513533156),PPP2R5E(1.87447468504),CALML3(3.12516519318),RYR2(4.46052172277),CREB3L1(1.97096098275),ATP1B3(1.30633831058),CACNA1C(2.69342627954),PPP2R2B(2.08831336367),CACNB2(3.05183936714),RPS6KA5(1.3539572607),GNAI3(1.07490060304),MYL4(5.351201467),ADCY8(16.2655676175),PIK3CD(1.35633899284),TPM4(1.25800984998),CACNG3(15.658352922),ADCY7(1.21035262862),CACNB4(1.11527147587)"]
["ko04144","Endocytosis","31/432","238/4515",0.0443634406974311,0.200936331434533,"HSPA2(1.00080821954),ACAP3(2.42539733303),SH3GL1(1.51225947689),PRKCI(1.75870497751),WASL(1.25893127884),PLD1(1.34395229016),PSD(2.51018982488),CHMP4C(1.9802546173),RAB11FIP4(2.19114347616),ARF6(2.00680127928),SNX5(1.99840903248),RAB11FIP1(1.24534838062),VPS4B(1.18795385995),ERBB3(1.43725792966),SNX2(1.13058363752),EHD4(1.24121851836),GRK4(1.5733507438),EPN2(1.02991528597),PARD6G(1.75828394412),PARD3(1.15278937622),RAB31(1.231831521),KIT(1.93015029938),VPS26B(1.08031441),AGAP3(1.12457517958),DNM1(1.59805789035),ARAP2(1.01295890828),ASAP1(1.07624481376),ARF3(1.05710087856),ASAP2(1.15088672986),STAM2(1.06505395183),PARD6B(1.09413860703)"]
["ko00140","Steroid hormone biosynthesis","7/432","35/4515",0.0445408868013215,0.200936331434533,"CYP3A5(2.81344727747),UGT2A1(1.42720368068),CYP3A4(1.85858425429),HSD17B7(1.91794043054),HSD11B2(1.56973388021),UGT1A1(1.19601852337),SRD5A3(1.02320479317)"]
["ko00830","Retinol metabolism","7/432","35/4515",0.0445408868013215,0.200936331434533,"ADH1C(4.25925000766),CYP3A5(2.81344727747),ALDH1A2(3.82167512505),UGT2A1(1.42720368068),CYP3A4(1.85858425429),RDH12(1.7077858315),UGT1A1(1.19601852337)"]