{"text_format":"3","workbook":"xlsx","n_sheets":2,"sheets":["DosR Regulon","Summary"],"read":"whole","date_system":"1900"}

{"sheet":"DosR Regulon","index":0,"n_rows":56,"n_cols":10,"rows_kept":56,"merged":[[0,0,0,1],[0,2,1,2],[0,3,1,3],[0,4,0,5],[0,6,0,7],[0,8,0,9],[13,0,14,0],[32,0,33,0],[48,0,49,0],[52,0,53,0]]}
["Gene",null,"In DEG List?",">1 Rv Homlogues? (#)","mc2155:FDL10",null,"FDL15:FDL10",null,"mc2155:FDL15"]
["H37Rv","mc2155",null,null,"RNA-Seq FC","p Value","RNA-Seq FC","p Value","RNA-Seq FC","p Value"]
["Rv0079","MSMEG_3935","Yes","No",{"v":1.457704488,"d":"1.4577"},{"v":0.054466042,"d":"0.0545"},{"v":1.882220687,"d":"1.8822"},{"v":0.005750101,"d":"0.0058"},{"v":-0.4245162,"d":"-0.4245"},{"v":0.585539582,"d":"0.5855"}]
["Rv0080","MSMEG_5136","Yes","No",{"v":-0.903506754,"d":"-0.9035"},{"v":0.136325594,"d":"0.1363"},{"v":-0.286538769,"d":"-0.2865"},{"v":0.570764226,"d":"0.5708"},{"v":-0.616967984,"d":"-0.6170"},{"v":0.320188376,"d":"0.3202"}]
["Rv0081","MSMEG_6451","Yes","No",{"v":-4.256305376,"d":"-4.2563"},{"v":0.174456101,"d":"0.1745"},{"v":-0.578636155,"d":"-0.5786"},{"v":0.668484457,"d":"0.6685"},{"v":-3.677669222,"d":"-3.6777"},{"v":0.289016387,"d":"0.2890"}]
["Rv0082","-","-","-","-","-","-","-","-","-"]
["Rv0083","-","-","-","-","-","-","-","-","-"]
["Rv0569","-","-","-","-","-","-","-","-","-"]
["Rv0570","-","-","-","-","-","-","-","-","-"]
["Rv0571c","-","-","-","-","-","-","-","-","-"]
["Rv0572c","-","-","-","-","-","-","-","-","-"]
["Rv0574c","-","-","-","-","-","-","-","-","-"]
["MT0639","-","-","-","-","-","-","-","-","-"]
["Rv1733c","MSMEG_1738","Yes","No",{"v":-1.0379327,"d":"-1.0379"},{"v":0.064090674,"d":"0.0641"},{"v":-0.789588967,"d":"-0.7896"},{"v":0.096100833,"d":"0.0961"},{"v":-0.248343734,"d":"-0.2483"},{"v":0.662763571,"d":"0.6628"}]
[null,"MSMEG_6676","Yes","No",{"v":1.256086352,"d":"1.2561"},{"v":0.369235087,"d":"0.3692"},{"v":-1.506049952,"d":"-1.5060"},{"v":0.332611534,"d":"0.3326"},{"v":2.762136304,"d":"2.7621"},{"v":0.130172691,"d":"0.1302"}]
["Rv1734c","-","-","-","-","-","-","-","-","-"]
["Rv1736c","-","-","-","-","-","-","-","-","-"]
["Rv1737c","MSMEG_5141","No","No","-","-","-","-","-","-"]
["Rv1738","-","-","-","-","-","-","-","-","-"]
["Rv1812c","-","-","-","-","-","-","-","-","-"]
["Rv18123c","-","-","-","-","-","-","-","-","-"]
["Rv1996","MSMEG_3945","Yes","Yes (3)",{"v":6.360426378,"d":"6.3604"},{"v":1.19e-11,"d":"1.19E-11"},{"v":5.868666947,"d":"5.8687"},{"v":4.9e-11,"d":"4.90E-11"},{"v":0.491759431,"d":"0.4918"},{"v":0.512474848,"d":"0.5125"}]
["Rv1997","MSMEG_3926","Yes","No",{"v":4.671864123,"d":"4.6719"},{"v":1.13E-8,"d":"1.13E-08"},{"v":3.062678405,"d":"3.0627"},{"v":9.35e-05,"d":"9.35E-05"},{"v":1.609185718,"d":"1.6092"},{"v":0.039014553,"d":"0.0390"}]
["Rv2003c","-","-","-","-","-","-","-","-","-"]
["Rv2004c","MSMEG_3942","Yes","No",{"v":2.758203836,"d":"2.7582"},{"v":2.72E-7,"d":"2.72E-07"},{"v":1.908068492,"d":"1.9081"},{"v":0.000108401,"d":"0.0001"},{"v":0.850135344,"d":"0.8501"},{"v":0.109265215,"d":"0.1093"}]
["Rv2005c","MSMEG_3945","Yes","Yes (3)",{"v":6.360426378,"d":"6.3604"},{"v":1.19e-11,"d":"1.19E-11"},{"v":5.868666947,"d":"5.8687"},{"v":4.9e-11,"d":"4.90E-11"},{"v":0.491759431,"d":"0.4918"},{"v":0.512474848,"d":"0.5125"}]
["Rv2006","MSMEG_3954","Yes","No",{"v":4.831198881,"d":"4.8312"},{"v":1.54e-10,"d":"1.54E-10"},{"v":3.420642143,"d":"3.4206"},{"v":1.26E-6,"d":"1.26E-06"},{"v":1.410556738,"d":"1.4106"},{"v":0.039770712,"d":"0.0398"}]
["Rv2007c","MSMEG_1124","No","No","-","-","-","-","-","-"]
["Rv2028c","MSMEG_5245","Yes","Yes (2)",{"v":1.248568765,"d":"1.2486"},{"v":0.007344959,"d":"0.0073"},{"v":0.825668551,"d":"0.8257"},{"v":0.050664764,"d":"0.0507"},{"v":0.422900215,"d":"0.4229"},{"v":0.371162238,"d":"0.3712"}]
["Rv2029c","MSMEG_3947","Yes","No",{"v":2.664466589,"d":"2.6645"},{"v":0.124115534,"d":"0.1241"},{"v":4.208069077,"d":"4.2081"},{"v":1.13042E-3,"d":"0.0011"},{"v":-1.543602488,"d":"-1.5436"},{"v":0.317551324,"d":"0.3176"}]
["Rv2030c","-","-","-","-","-","-","-","-","-"]
["Rv2031c","MSMEG_3932","Yes","No",{"v":3.155339018,"d":"3.1553"},{"v":0.042374344,"d":"0.0424"},{"v":2.935824098,"d":"2.9358"},{"v":0.030724756,"d":"0.0307"},{"v":0.21951492,"d":"0.2195"},{"v":0.879611634,"d":"0.8796"}]
["Rv2032","MSMEG_3943","Yes","No",{"v":2.30454425,"d":"2.3045"},{"v":0.002706287,"d":"0.0027"},{"v":2.788106748,"d":"2.7881"},{"v":5.9e-05,"d":"5.90E-05"},{"v":-0.483562498,"d":"-0.4836"},{"v":0.526716301,"d":"0.5267"}]
[null,"MSMEG_5246","Yes","No",{"v":0.954458073,"d":"0.9545"},{"v":0.053095197,"d":"0.0531"},{"v":0.310072922,"d":"0.3101"},{"v":0.485814659,"d":"0.4858"},{"v":0.644385151,"d":"0.6444"},{"v":0.201312971,"d":"0.2013"}]
["Rv2623","MSMEG_3945","Yes","Yes (3)",{"v":6.360426378,"d":"6.3604"},{"v":1.19e-11,"d":"1.19E-11"},{"v":5.868666947,"d":"5.8687"},{"v":4.9e-11,"d":"4.90E-11"},{"v":0.491759431,"d":"0.4918"},{"v":0.512474848,"d":"0.5125"}]
["Rv2624c","MSMEG_3939","Yes","No",{"v":3.397582708,"d":"3.3976"},{"v":1.08497E-4,"d":"0.0001"},{"v":2.876723882,"d":"2.8767"},{"v":0.000327536,"d":"0.0003"},{"v":0.520858826,"d":"0.5209"},{"v":0.535915024,"d":"0.5359"}]
["Rv2625c","-","-","-","-","-","-","-","-","-"]
["Rv2626c","-","-","-","-","-","-","-","-","-"]
["Rv2627c","-","-","-","-","-","-","-","-","-"]
["Rv2628","-","-","-","-","-","-","-","-","-"]
["Rv2629","-","-","-","-","-","-","-","-","-"]
["Rv2630","-","-","-","-","-","-","-","-","-"]
["Rv2631","-","-","-","-","-","-","-","-","-"]
["Rv2830c","-","-","-","-","-","-","-","-","-"]
["Rv3126c","-","-","-","-","-","-","-","-","-"]
["Rv3127","-","-","-","-","-","-","-","-","-"]
["Rv3128c","-","-","-","-","-","-","-","-","-"]
["Rv3129","MSMEG_6368","Yes","No",{"v":-4.751169025,"d":"-4.7512"},{"v":0.123108903,"d":"0.1231"},{"v":0.52726048,"d":"0.5273"},{"v":0.65140757,"d":"0.6514"},{"v":-5.278429505,"d":"-5.2784"},{"v":0.084941196,"d":"0.0849"}]
["Rv3130c","MSMEG_3948","Yes","No",{"v":3.355984105,"d":"3.3560"},{"v":6.22e-06,"d":"6.22E-06"},{"v":2.905251614,"d":"2.9053"},{"v":2.31e-05,"d":"2.31E-05"},{"v":0.450732491,"d":"0.4507"},{"v":0.528143505,"d":"0.5281"}]
[null,"MSMEG_5242","Yes","No",{"v":1.188936304,"d":"1.1889"},{"v":0.107299289,"d":"0.1073"},{"v":0.977177271,"d":"0.9772"},{"v":0.139509986,"d":"0.1395"},{"v":0.211759032,"d":"0.2118"},{"v":0.780625033,"d":"0.7806"}]
["Rv3131","MSMEG_3955","Yes","No",{"v":0.156126793,"d":"0.1561"},{"v":0.914621873,"d":"0.9146"},{"v":1.946425711,"d":"1.9464"},{"v":0.064587774,"d":"0.0646"},{"v":-1.790298918,"d":"-1.7903"},{"v":0.226340816,"d":"0.2263"}]
["Rv3132c","MSMEG_5241","Yes","No",{"v":0.335687998,"d":"0.3357"},{"v":0.667577303,"d":"0.6676"},{"v":1.207543851,"d":"1.2075"},{"v":0.065625311,"d":"0.0656"},{"v":-0.871855854,"d":"-0.8719"},{"v":0.27804073,"d":"0.2780"}]
["Rv3133c","MSMEG_3944","Yes","No",{"v":5.097792623,"d":"5.0978"},{"v":3.01e-09,"d":"3.01E-09"},{"v":4.54483808,"d":"4.5448"},{"v":2.16e-08,"d":"2.16E-08"},{"v":0.552954542,"d":"0.5530"},{"v":0.468186493,"d":"0.4682"}]
[null,"MSMEG_5244","Yes","No",{"v":1.063112074,"d":"1.0631"},{"v":0.021841703,"d":"0.0218"},{"v":0.613972665,"d":"0.6140"},{"v":0.143648353,"d":"0.1436"},{"v":0.449139409,"d":"0.4491"},{"v":0.340462693,"d":"0.3405"}]
["Rv3134c","MSMEG_5245","Yes","Yes (2)",{"v":1.248568765,"d":"1.2486"},{"v":0.007344959,"d":"0.0073"},{"v":0.825668551,"d":"0.8257"},{"v":0.050664764,"d":"0.0507"},{"v":0.422900215,"d":"0.4229"},{"v":0.371162238,"d":"0.3712"}]
["Rv3841","MSMEG_6422","Yes","No",{"v":1.253517897,"d":"1.2535"},{"v":7.058641E-3,"d":"0.0071"},{"v":0.804051036,"d":"0.8041"},{"v":0.055150214,"d":"0.0552"},{"v":0.449466862,"d":"0.4495"},{"v":0.339439677,"d":"0.3394"}]

{"sheet":"Summary","index":1,"n_rows":15,"n_cols":2,"rows_kept":15}
["Mtb DosR Regulon (Park, 2003) = 50 genes"]
[]
["26 Mtb genes have no homologue in M. smegmatis"]
["2 MSMEG homologues are not in the RNA-Seq DEG list (MSMEG 1124 & MSMEG 5141)"]
["MSMEG 3945 maps to three separate Mtb homologues (Rv1996, Rv2005c, & Rv2623)"]
["MSMEG 5245 maps to two separate Mtb homologues (Rv2028c & Rv3134c)"]
["Four Mtb genes map to two Msmeg homologues"]
[null,"Rv1733c --> MSMEG 1738 & MSMEG 6676"]
[null,"Rv2032 --> MSMEG 3943 & MSMEG 5246"]
[null,"Rv3130 --> MSMEG 3948 & MSMEG 5242"]
[null,"Rv3133c --> MSMEG 3944 & MSMEG 5244"]
[]
["23 MSMEG homologues differentially expressed (<-2 or > 2) in any pairwise comparison among three strains; 17 of which were statistically significant (p < 0.05)"]
["Note that all fold change values represent values in wild-type (mc2155) or complentation strain (FDL15) relative to the prrAB mutant (FDL10) "]
[null,"Fold change values between mc2155 and FDL15 represent the values in mc2155 relative to FDL15"]