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{"sheet":"common_genes_enriched_pathways","index":0,"n_rows":138,"n_cols":12,"rows_kept":138,"merged":[[0,0,0,11],[34,0,34,8],[129,0,129,9]],"flags":["formulas_cached_only"]}
["KEGG"]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes",null,null,"* Enrichr used many databases, the most significantly accepted are shown here, KEGG, Recatome and biocarta."]
["Bone remodeling","1/18.",{"v":0.000899978892795027,"d":"9.00E-04"},0.00539987335677016,0,0,19982,140136.548440846,"IRF9"]
["Activation of Matrix Metalloproteinases Homo sapiens R-HSA-1592389","1/32.",{"v":0.00159996838044672,"d":"1.60E-03"},0.00389992759110169,0,0,19968,128549.41955786,"MMP8"]
["Necroptosis","2/162",0.029216259921945726,0.2115354726039056,0,0,7.986693548387096,28.21722693326069,"HIST2H2AA4;IRF9"]
["RNA transport","2/165",0.030219353229129373,0.2115354726039056,0,0,7.8385117751830595,27.429090455154732,"PABPC1;EIF4B"]
["Mucin type O-glycan biosynthesis","1/31",0.049940304558029364,0.2796657055249644,0,0,20.767708333333335,62.2393036656038,"B4GALT5"]
["Legionellosis","1/55",0.08693440635065318,0.3176952193786537,0,0,11.523726851851851,28.1478712802825,"EEF1G"]
["Arachidonic acid metabolism","1/63",0.09895242773995688,0.3176952193786537,0,0,10.032762096774194,23.206943254780835,"PTGDS"]
["Aminoacyl-tRNA biosynthesis","1/66",0.10341952165070845,0.3176952193786537,0,0,9.56826923076923,21.710034863454165,"NARS2"]
["RNA degradation","1/79",0.12253001533957616,0.3176952193786537,0,0,7.9683493589743595,16.72874671442756,"PABPC1"]
["mRNA surveillance pathway","1/91",0.139819477714127,0.3176952193786537,0,0,6.901736111111111,13.578497250356977,"PABPC1"]
["C-type lectin receptor signaling pathway","1/104",0.15817691491762378,0.3176952193786537,0,0,6.026699029126213,11.113481054776814,"IRF9"]
["Parathyroid hormone synthesis secretion and action","1/106",0.1609672024230657,0.3176952193786537,0,0,5.911309523809524,10.79732987706831,"NACA"]
["Osteoclast differentiation","1/127",0.1897290089475027,0.3176952193786537,0,0,4.920882936507937,8.179287368969138,"IRF9"]
["Autophagy","1/128",0.19107449804618964,0.3176952193786537,0,0,4.881889763779528,8.07997613079071,"VMP1"]
["Systemic lupus erythematosus","1/133",0.197769511298914,0.3176952193786537,0,0,4.695785984848484,7.6102396939897305,"HIST2H2AA4"]
["Measles","1/138",0.2044107794284892,0.3176952193786537,0,0,4.523266423357664,7.181244907799647,"IRF9"]
["Hepatitis C","1/155",0.22659468057116097,0.3176952193786537,0,0,4.02049512987013,5.968796536704066,"IRF9"]
["JAK-STAT signaling pathway","1/162",0.23555383040012978,0.3176952193786537,0,0,3.844332298136646,5.55819642496648,"IRF9"]
["Influenza A","1/171",0.24692496254586657,0.3176952193786537,0,0,3.639154411764706,5.089978953727575,"IRF9"]
["NOD-like receptor signaling pathway","1/178",0.2556556106030033,0.3176952193786537,0,0,3.493997175141243,4.765546642498988,"IRF9"]
["Alcoholism","1/180",0.258132000553754,0.3176952193786537,0,0,3.454608938547486,4.678522284845952,"HIST2H2AA4"]
["Kaposi sarcoma-associated herpesvirus infection","1/186",0.26551333050304055,0.3176952193786537,0,0,3.341554054054054,4.431202185800747,"IRF9"]
["Epstein-Barr virus infection","1/201",0.2836564458737979,0.3176952193786537,0,0,3.08859375,3.891601781528958,"IRF9"]
["Proteoglycans in cancer","1/201",0.2836564458737979,0.3176952193786537,0,0,3.08859375,3.891601781528958,"EIF4B"]
["Viral carcinogenesis","1/201",0.2836564458737979,0.3176952193786537,0,0,3.08859375,3.891601781528958,"IRF9"]
["Human papillomavirus infection","1/330",0.4227526894187015,0.4552721270662939,0,0,1.8653115501519757,1.6059734232067182,"IRF9"]
["PI3K-Akt signaling pathway","1/354",0.4455652676305008,0.4620676849501489,0,0,1.7363668555240792,1.4036990012150425,"EIF4B"]
["Herpes simplex virus 1 infection","1/492",0.560719378459645,0.560719378459645,0,0,1.2395621181262728,0.7171297170560257,"IRF9"]
[]
[]
[]
["Reactome"]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Translation Homo sapiens R-HSA-72766","6/151",1.5689785578997118e-07,1.4591500588467322e-05,0,0,30.378544061302684,475.9610290540333,"EEF1G;RPL5;RPS8;RPS2;PABPC1;EIF4B"]
["L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827","5/106",8.01890030967443e-07,2.1405251117022852e-05,0,0,35.12376237623762,493.00746763734855,"RPL5;RPS8;RPS2;PABPC1;EIF4B"]
["3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279","5/106",8.01890030967443e-07,2.1405251117022852e-05,0,0,35.12376237623762,493.00746763734855,"RPL5;RPS8;RPS2;PABPC1;EIF4B"]
["Cap-dependent Translation Initiation Homo sapiens R-HSA-72737","5/114",1.15081995252811e-06,2.1405251117022852e-05,0,0,32.532765399737876,444.8867337089492,"RPL5;RPS8;RPS2;PABPC1;EIF4B"]
["Eukaryotic Translation Initiation Homo sapiens R-HSA-72613","5/114",1.15081995252811e-06,2.1405251117022852e-05,0,0,32.532765399737876,444.8867337089492,"RPL5;RPS8;RPS2;PABPC1;EIF4B"]
["Translation initiation complex formation Homo sapiens R-HSA-72649","4/57",2.280412767507577e-06,3.2503415294233075e-05,0,0,51.82563435263501,673.2748018427048,"RPS8;RPS2;PABPC1;EIF4B"]
["Activation of the mRNA upon binding of the cap-binding complex and eIFs  and subsequent binding to 43S Homo sapiens R-HSA-72662","4/58",2.4464936242971124e-06,3.2503415294233075e-05,0,0,50.863346104725416,657.1979062163928,"RPS8;RPS2;PABPC1;EIF4B"]
["Eukaryotic Translation Elongation Homo sapiens R-HSA-156842","4/89",1.3582130432489096e-05,0.00014034868113572065,0,0,32.26288032454361,361.56221371628993,"EEF1G;RPL5;RPS8;RPS2"]
["Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956","4/89",1.3582130432489096e-05,0.00014034868113572065,0,0,32.26288032454361,361.56221371628993,"RPL5;RPS8;RPS2;PABPC1"]
["Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802","4/106",2.7094515788232974e-05,0.00021788434558088469,0,0,26.862745098039216,282.4934417920487,"RPL5;RPS8;RPS2;PABPC1"]
["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957","4/106",2.7094515788232974e-05,0.00021788434558088469,0,0,26.862745098039216,282.4934417920487,"RPL5;RPS8;RPS2;PABPC1"]
["GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706","4/107",2.8114109107210926e-05,0.00021788434558088469,0,0,26.6006026113157,278.7540724191087,"RPL5;RPS8;RPS2;EIF4B"]
["Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702","3/57",0.00011268867532475409,0.0008061574465540101,0,0,36.87592592592593,335.2346774825671,"RPS8;RPS2;EIF4B"]
["Viral mRNA Translation Homo sapiens R-HSA-192823","3/84",0.0003560088261502225,0.002159226015654751,0,0,24.55061728395062,194.945527683063,"RPL5;RPS8;RPS2"]
["Peptide chain elongation Homo sapiens R-HSA-156902","3/84",0.0003560088261502225,0.002159226015654751,0,0,24.55061728395062,194.945527683063,"RPL5;RPS8;RPS2"]
["Selenocysteine synthesis Homo sapiens R-HSA-2408557","3/87",0.0003946972286680728,0.002159226015654751,0,0,23.670238095238094,185.51292513910482,"RPL5;RPS8;RPS2"]
["Eukaryotic Translation Termination Homo sapiens R-HSA-72764","3/87",0.0003946972286680728,0.002159226015654751,0,0,23.670238095238094,185.51292513910482,"RPL5;RPS8;RPS2"]
["Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689","3/96",0.0005267017789872393,0.0027212925247674024,0,0,21.36989247311828,161.3186695641108,"RPL5;RPS8;RPS2"]
["Deadenylation of mRNA Homo sapiens R-HSA-429947","2/23",0.0006536021659098826,0.0031992106015588987,0,0,61.27803379416282,449.3525388028706,"PABPC1;EIF4B"]
["SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339","3/107",0.0007227083107022025,0.0033605936447652423,0,0,19.099038461538463,138.1338884986573,"RPL5;RPS8;RPS2"]
["Selenoamino acid metabolism Homo sapiens R-HSA-2408522","3/111",0.0008040414469803793,0.0035607549794845366,0,0,18.387962962962963,131.03004496263762,"RPL5;RPS8;RPS2"]
["Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273","3/128",0.0012140747496728371,0.0051322250781624485,0,0,15.8736,106.57174733405486,"RPL5;RPS8;RPS2"]
["Influenza Life Cycle Homo sapiens R-HSA-168255","3/136",0.0014452611699372546,0.005843882121920205,0,0,14.912781954887219,97.52161912589267,"RPL5;RPS8;RPS2"]
["Metabolism of proteins Homo sapiens R-HSA-392499","7/1074",0.0015770561210884707,0.006111092469217825,0,0,4.768942397808377,30.77014812754896,"EEF1G;RPL5;RPS8;RPS2;PABPC1;EIF4B;B4GALT5"]
["Influenza Infection Homo sapiens R-HSA-168254","3/147",0.0018057475671611704,0.006717380949839555,0,0,13.765972222222222,86.95662638783391,"RPL5;RPS8;RPS2"]
["Infectious disease Homo sapiens R-HSA-5663205","4/348",0.002474981192741742,0.008788977720552083,0,0,7.868083400160385,47.22047941538969,"RPL5;RPS8;NMT2;RPS2"]
["Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226","3/166",0.0025516386930635082,0.008788977720552083,0,0,12.149693251533742,72.54605534185774,"RPL5;RPS8;RPS2"]
["Deadenylation-dependent mRNA decay Homo sapiens R-HSA-429914","2/50",0.0030778471463162632,0.009870337400255601,0,0,26.772849462365592,154.84144163978604,"PABPC1;EIF4B"]
["Formation of the ternary complex and subsequently the 43S complex Homo sapiens R-HSA-72695","2/50",0.0030778471463162632,0.009870337400255601,0,0,26.772849462365592,154.84144163978604,"RPS8;RPS2"]
["rRNA processing Homo sapiens R-HSA-72312","3/180",0.0032072154737587664,0.009942367968652176,0,0,11.180790960451978,64.20403925591017,"RPL5;RPS8;RPS2"]
["Gene Expression Homo sapiens R-HSA-74160","7/1631",0.015384223371728957,0.04615267011518688,0,0,3.040948275862069,12.694173258066147,"EEF1G;RPL5;RPS8;NARS2;RPS2;PABPC1;EIF4B"]
["Rho GTPase cycle Homo sapiens R-HSA-194840","2/122",0.017224699357887216,0.047842714327559044,0,0,10.670430107526881,43.33700131774797,"ARHGAP32;RHOF"]
["Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291","3/335",0.017530405435293696,0.047842714327559044,0,0,5.914156626506024,23.915775695664195,"RPL5;RPS8;RPS2"]
["Membrane binding and targetting of GAG proteins Homo sapiens R-HSA-174490","1/11",0.018005322596393192,0.047842714327559044,0,0,62.365625,250.52819538044852,"NMT2"]
["Synthesis And Processing Of GAG GAGPOL Polyproteins Homo sapiens R-HSA-174495","1/11",0.018005322596393192,0.047842714327559044,0,0,62.365625,250.52819538044852,"NMT2"]
["Assembly Of The HIV Virion Homo sapiens R-HSA-175474","1/13",0.02124507913562837,0.05199453577930101,0,0,51.966145833333336,200.1543652635479,"NMT2"]
["Activation of DNA fragmentation factor Homo sapiens R-HSA-211227","1/13",0.02124507913562837,0.05199453577930101,0,0,51.966145833333336,200.1543652635479,"HIST1H1C"]
["Apoptosis induced DNA fragmentation Homo sapiens R-HSA-140342","1/13",0.02124507913562837,0.05199453577930101,0,0,51.966145833333336,200.1543652635479,"HIST1H1C"]
["Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Homo sapiens R-HSA-2162123","1/14",0.022861068741375046,0.05451485622943279,0,0,47.96634615384615,181.23219876999113,"PTGDS"]
["N-Glycan antennae elongation Homo sapiens R-HSA-975577","1/15",0.024474471226601003,0.05690314560184733,0,0,44.53794642857143,165.24133492847943,"B4GALT5"]
["Formation of Senescence-Associated Heterochromatin Foci (SAHF) Homo sapiens R-HSA-2559584","1/17",0.02769353076527467,0.06281703319928157,0,0,38.966796875,139.75661625657744,"HIST1H1C"]
["Disease Homo sapiens R-HSA-1643685","4/725",0.03045814061944287,0.0674430256573378,0,0,3.681859486345593,12.854851488677042,"RPL5;RPS8;NMT2;RPS2"]
["Mitochondrial tRNA aminoacylation Homo sapiens R-HSA-379726","1/21",0.03410077958834001,0.07375284887710745,0,0,31.1671875,105.2963181340018,"NARS2"]
["mTORC1-mediated signalling Homo sapiens R-HSA-166208","1/22",0.035696183669855816,0.07544875184764979,0,0,29.68154761904762,98.92003496654242,"EIF4B"]
["N-glycan antennae elongation in the medial/trans-Golgi Homo sapiens R-HSA-975576","1/26",0.042052286305533364,0.08690805836476896,0,0,24.9275,78.99129706265623,"B4GALT5"]
["Keratan sulfate biosynthesis Homo sapiens R-HSA-2022854","1/27",0.043634953289916796,0.08821849252091873,0,0,23.967548076923077,75.0638863791398,"B4GALT5"]
["Activation of Matrix Metalloproteinases Homo sapiens R-HSA-1592389","1/32",0.05151033282685189,0.09980126985202557,0,0,20.096774193548388,59.60648671149129,"MMP8"]
["Keratan sulfate/keratin metabolism Homo sapiens R-HSA-1638074","1/32",0.05151033282685189,0.09980126985202557,0,0,20.096774193548388,59.60648671149129,"B4GALT5"]
["Inactivation recovery and regulation of the phototransduction cascade Homo sapiens R-HSA-2514859","1/33",0.0530778450894783,0.10073958353717309,0,0,19.4677734375,57.15729847328148,"NMT2"]
["The phototransduction cascade Homo sapiens R-HSA-2514856","1/34",0.054642845266702496,0.10163569219606665,0,0,18.876893939393938,54.873941288604264,"NMT2"]
["Collagen degradation Homo sapiens R-HSA-1442490","1/39",0.062430300890362264,0.11165419197699404,0,0,16.388980263157894,45.45818880252994,"MMP8"]
["mTOR signalling Homo sapiens R-HSA-165159","1/39",0.062430300890362264,0.11165419197699404,0,0,16.388980263157894,45.45818880252994,"EIF4B"]
["PKB-mediated events Homo sapiens R-HSA-109703","1/40",0.0639803101343835,0.11226733665089937,0,0,15.967948717948717,43.8987636134356,"EIF4B"]
["tRNA Aminoacylation Homo sapiens R-HSA-379724","1/42",0.0670728776613437,0.1155144004167586,0,0,15.1875,41.036253277555026,"NARS2"]
["Apoptotic execution  phase Homo sapiens R-HSA-75153","1/51",0.08086725188148412,0.1367391713632368,0,0,12.448125,31.30636633865138,"HIST1H1C"]
["Arachidonic acid metabolism Homo sapiens R-HSA-2142753","1/53",0.08390569957761398,0.1393433939413947,0,0,11.968149038461538,29.65781216894516,"PTGDS"]
["AUF1 (hnRNP D0) binds and destabilizes mRNA Homo sapiens R-HSA-450408","1/54",0.08542126868690271,0.1393715436470518,0,0,11.741745283018869,28.886573969871716,"PABPC1"]
["rRNA modification in the nucleus Homo sapiens R-HSA-6790901","1/58",0.09145926840160942,0.14653445379883936,0,0,10.915570175438596,26.10853270693433,"RPS2"]
["DNA Damage/Telomere Stress Induced Senescence Homo sapiens R-HSA-2559586","1/59",0.09296271800141423,0.14653445379883936,0,0,10.726831896551724,25.48219789553526,"HIST1H1C"]
["O-linked glycosylation of mucins Homo sapiens R-HSA-913709","1/66",0.10341952165070845,0.16030025855859809,0,0,9.56826923076923,21.710034863454165,"B4GALT5"]
["Interferon alpha/beta signaling Homo sapiens R-HSA-909733","1/68",0.10638564563751897,0.1621945089227748,0,0,9.281716417910447,20.797399230359275,"IRF9"]
["Signaling by Rho GTPases Homo sapiens R-HSA-194315","2/367",0.12239071189041698,0.1808776416917553,0,0,3.464781263809103,7.277900531366479,"ARHGAP32;RHOF"]
["PI3K Cascade Homo sapiens R-HSA-109704","1/79",0.12253001533957616,0.1808776416917553,0,0,7.9683493589743595,16.72874671442756,"EIF4B"]
["Regulation of mRNA stability by proteins that bind AU-rich elements Homo sapiens R-HSA-450531","1/86",0.1326560603433393,0.1927658376864149,0,0,7.309558823529412,14.765276023510664,"PABPC1"]
["Interferon gamma signaling Homo sapiens R-HSA-877300","1/93",0.1426687520182198,0.2041260605799145,0,0,6.751019021739131,13.145785117221337,"IRF9"]
["Visual phototransduction Homo sapiens R-HSA-2187338","1/97",0.14833987054087114,0.2090243630348639,0,0,6.468424479166667,12.34336593719902,"NMT2"]
["Degradation of the extracellular matrix Homo sapiens R-HSA-1474228","1/106",0.1609672024230657,0.2234320869454494,0,0,5.911309523809524,10.79732987706831,"MMP8"]
["O-linked glycosylation Homo sapiens R-HSA-5173105","1/110",0.16652089761775046,0.22774181585957048,0,0,5.6932339449541285,10.205887393977246,"B4GALT5"]
["Glycosaminoglycan metabolism Homo sapiens R-HSA-1630316","1/121",0.18161038494473145,0.24477921449072498,0,0,5.168489583333334,8.816883112874782,"B4GALT5"]
["Late Phase of HIV Life Cycle Homo sapiens R-HSA-162599","1/128",0.19107449804618964,0.2538561188327948,0,0,4.881889763779528,8.07997613079071,"NMT2"]
["Metabolism Homo sapiens R-HSA-1430728","5/1908",0.20222775327409895,0.26488987400691827,0,0,1.6950679378425044,2.709330018505296,"RPL5;RPS8;RPS2;PTGDS;B4GALT5"]
["HIV Life Cycle Homo sapiens R-HSA-162587","1/141",0.2083699166667787,0.2691444756945892,0,0,4.425669642857143,6.941398769847703,"NMT2"]
["Cellular Senescence Homo sapiens R-HSA-2559583","1/161",0.23428014127720115,0.29366357659504655,0,0,3.8685546875,5.614192386638307,"HIST1H1C"]
["Transport to the Golgi and subsequent modification Homo sapiens R-HSA-948021","1/162",0.23555383040012978,0.29366357659504655,0,0,3.844332298136646,5.55819642496648,"B4GALT5"]
["Apoptosis Homo sapiens R-HSA-109581","1/163",0.2368254649960053,0.29366357659504655,0,0,3.820408950617284,5.503038708670886,"HIST1H1C"]
["Programmed Cell Death Homo sapiens R-HSA-5357801","1/166",0.2406280736274591,0.29445277430728545,0,0,3.750378787878788,5.342425086287716,"HIST1H1C"]
["Interferon Signaling Homo sapiens R-HSA-913531","1/196",0.2776575702089545,0.3353526497328931,0,0,3.1685897435897434,4.0601253402157065,"IRF9"]
["HIV Infection Homo sapiens R-HSA-162906","1/222",0.308328425459228,0.3676223534321564,0,0,2.792138009049774,3.2852009555948016,"NMT2"]
["Asparagine N-linked glycosylation Homo sapiens R-HSA-446203","1/259",0.3498076978728334,0.41160307405763474,0,0,2.387233527131783,2.5074825624023314,"B4GALT5"]
["Metabolism of carbohydrates Homo sapiens R-HSA-71387","1/282",0.3743652800877526,0.41160307405763474,0,0,2.189279359430605,2.1510179228056994,"B4GALT5"]
["Extracellular matrix organization Homo sapiens R-HSA-1474244","1/283",0.3754123391149562,0.41160307405763474,0,0,2.1814051418439715,2.137188683770918,"MMP8"]
["IRS-mediated signalling Homo sapiens R-HSA-112399","1/284",0.37645769882385277,0.41160307405763474,0,0,2.1735865724381624,2.123484514632926,"EIF4B"]
["Insulin receptor signalling cascade Homo sapiens R-HSA-74751","1/287",0.3795836085140997,0.41160307405763474,0,0,2.1504589160839163,2.083107390374312,"EIF4B"]
["IGF1R signaling cascade Homo sapiens R-HSA-2428924","1/288",0.3806221975156623,0.41160307405763474,0,0,2.1428571428571432,2.069888578701249,"EIF4B"]
["Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Homo sapiens R-HSA-2404192","1/288",0.3806221975156623,0.41160307405763474,0,0,2.1428571428571432,2.069888578701249,"EIF4B"]
["IRS-related events triggered by IGF1R Homo sapiens R-HSA-2428928","1/288",0.3806221975156623,0.41160307405763474,0,0,2.1428571428571432,2.069888578701249,"EIF4B"]
["Signaling by Insulin receptor Homo sapiens R-HSA-74752","1/311",0.40404972678809103,0.4319152251872697,0,0,1.9815524193548386,1.79571712783404,"EIF4B"]
["Cellular responses to stress Homo sapiens R-HSA-2262752","1/367",0.4575545161781301,0.4835519318700694,0,0,1.673582650273224,1.3085060595563278,"HIST1H1C"]
["Post-translational protein modification Homo sapiens R-HSA-597592","1/521",0.5817811166727744,0.6079285825906521,0,0,1.1686899038461538,0.633033730531505,"B4GALT5"]
["Signal Transduction Homo sapiens R-HSA-162582","4/2465",0.5932731345489392,0.6130489057005705,0,0,0.9811542826717482,0.5122610318049776,"ARHGAP32;NMT2;RHOF;EIF4B"]
[]
[]
["Biocarta"]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Eukaryotic protein translation Homo sapiens h eifPathway","2/14",0.0024290159012020714,0.0510093339252435,0,0,31.862179487179485,191.81889407044008,"EIF4A2;EIF2S3"]
["Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway Homo sapiens h igf1mtorpathway","2/25",0.007709644419990716,0.08095126640990252,0,0,16.61454849498328,80.8344838642323,"EIF2S3;PABPC1"]
["Visceral Fat Deposits and the Metabolic Syndrome Homo sapiens h vobesityPathway","1/8",0.04162869457822453,0.1797070574246123,0,0,27.057142857142857,86.01372572734715,"TNF"]
["SODD/TNFR1 Signaling Pathway Homo sapiens h soddPathway","1/9",0.04671008178648439,0.1797070574246123,0,0,23.673809523809524,72.5317052519737,"TNF"]
["Regulation of eIF2 Homo sapiens h eif2Pathway","1/11",0.05679292971226178,0.1797070574246123,0,0,18.937142857142856,54.31822944685532,"EIF2S3"]
["IL-10 Anti-inflammatory Signaling Pathway Homo sapiens h il10Pathway","1/13",0.06677013024916706,0.1797070574246123,0,0,15.77936507936508,42.70684291496826,"TNF"]

{"sheet":"RA_up_pathways_enriched","index":1,"n_rows":53,"n_cols":9,"rows_kept":53,"merged":[[0,0,0,8],[2,0,2,8],[11,0,11,8],[41,0,41,8]],"flags":["formulas_cached_only"]}
["RA_up"]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["KEGG Pathways"]
["African trypanosomiasis","2/37",0.004815935065582158,0.3178517143284224,0,0,21.067724867724866,112.41369418265441,"NPPA;HBA2"]
["Human T-cell leukemia virus 1 infection","3/219",0.023466698504793364,0.363720281461263,0,0,5.169811320754717,19.39802618270143,"MAP2K4;IL1R1;MSX1"]
["TNF signaling pathway","2/110",0.03807648460583783,0.363720281461263,0,0,6.802469135802469,22.231546574423238,"MAP2K4;IL18R1"]
["Osteoclast differentiation","2/127",0.04931854596275087,0.363720281461263,0,0,5.872296296296296,17.672411936694196,"IL1R1;IRF9"]
["Purine metabolism","2/129",0.050711805011736624,0.363720281461263,0,0,5.779235928842228,17.231349936083543,"PKM;GMPR"]
["Systemic lupus erythematosus","2/133",0.053540650780282396,0.363720281461263,0,0,5.601639807746678,16.397759113546858,"HIST2H2AA4;HIST1H3J"]
["Fluid shear stress and atherosclerosis","2/139",0.057886828266258,0.363720281461263,0,0,5.354690456880238,15.256934307364943,"MAP2K4;IL1R1"]
[]
["Reactome pathways"]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Regulation of TP53 Activity through Association with Co-factors Homo sapiens R-HSA-6804759","2/14",0.0005467878206419364,0.09514108079169693,0,0,69.22916666666667,520.0114050756229,"PHF20;BANP"]
["Extracellular matrix organization Homo sapiens R-HSA-1474244","4/283",0.005422732372908225,0.37783537654367605,0,0,6.130902290790089,31.985870377782664,"COL6A2;FBLN2;CD44;JAM3"]
["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Homo sapiens R-HSA-198933","3/157",0.007100915098721522,0.37783537654367605,0,0,8.205029013539653,40.594640455474256,"KLRB1;KLRF1;CD1C"]
["Integrin cell surface interactions Homo sapiens R-HSA-216083","2/67",0.012210781302115073,0.37783537654367605,0,0,12.746794871794872,56.15518906635068,"CD44;JAM3"]
["Abacavir transmembrane transport Homo sapiens R-HSA-2161517","1/5",0.012438777192772536,0.37783537654367605,0,0,101.76530612244898,446.4379351400606,"ABCB1"]
["Vitamins Homo sapiens R-HSA-211916","1/6",0.014908284799373636,0.37783537654367605,0,0,81.40816326530613,342.3895623444841,"CYP2R1"]
["Vitamin D (calciferol) metabolism Homo sapiens R-HSA-196791","1/7",0.017371741450283952,0.37783537654367605,0,0,67.83673469387755,274.9362107684438,"CYP2R1"]
["Histidine catabolism Homo sapiens R-HSA-70921","1/7",0.017371741450283952,0.37783537654367605,0,0,67.83673469387755,274.9362107684438,"HDC"]
["Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA Homo sapiens R-HSA-428359","1/8",0.01982916145118511,0.3814333418526052,0,0,58.142857142857146,227.9549801512961,"CD44"]
["Abacavir transport and metabolism Homo sapiens R-HSA-2161522","1/10",0.02472594881725805,0.3814333418526052,0,0,45.21768707482993,167.3010120823387,"ABCB1"]
["Cell surface interactions at the vascular wall Homo sapiens R-HSA-202733","2/101",0.02643151920502357,0.3814333418526052,0,0,8.35479797979798,30.35463590957481,"CD44;JAM3"]
["Hyaluronan uptake and degradation Homo sapiens R-HSA-2160916","1/12",0.0295987615689071,0.3814333418526052,0,0,36.99257884972171,130.2147194065139,"CD44"]
["Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Homo sapiens R-HSA-112308","1/13",0.03202621324876303,0.3814333418526052,0,0,33.90816326530612,116.6847899929619,"CACNA2D3"]
["Synthesis of bile acids and bile salts via 24-hydroxycholesterol Homo sapiens R-HSA-193775","1/14",0.03444771416987116,0.3814333418526052,0,0,31.298273155416013,105.4223689491126,"SLC27A5"]
["Recycling of bile acids and salts Homo sapiens R-HSA-159418","1/15",0.03686327859360632,0.3814333418526052,0,0,29.06122448979592,95.91771596133705,"SLC27A5"]
["Regulation of KIT signaling Homo sapiens R-HSA-1433559","1/16",0.03927292073446524,0.3814333418526052,0,0,27.122448979591837,87.80133530116419,"KIT"]
["TRAF6 mediated induction of TAK1 complex Homo sapiens R-HSA-937072","1/16",0.03927292073446524,0.3814333418526052,0,0,27.122448979591837,87.80133530116419,"SARM1"]
["Axon guidance Homo sapiens R-HSA-422475","4/515",0.03945862157095916,0.3814333418526052,0,0,3.307921381774866,10.692864835387747,"EPHA4;ROBO3;COL6A2;KIT"]
["Hyaluronan metabolism Homo sapiens R-HSA-2142845","1/17",0.04167665479123348,0.3816704175618224,0,0,25.426020408163264,80.79916728086499,"CD44"]
["Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Homo sapiens R-HSA-936964","1/18",0.04407449493169267,0.3834481059057262,0,0,23.929171668667472,74.70385911458476,"SARM1"]
["mTORC1-mediated signalling Homo sapiens R-HSA-166208","1/22",0.053607198599254786,0.3923529135532057,0,0,19.367346938775512,56.67024999786951,"EIF4B"]
["Regulation of TP53 Activity Homo sapiens R-HSA-5633007","2/151",0.054805067510828746,0.3923529135532057,0,0,5.537192393736018,16.079855083580625,"PHF20;BANP"]
["Deadenylation of mRNA Homo sapiens R-HSA-429947","1/23",0.05597578058787951,0.3923529135532057,0,0,18.4860853432282,53.29235549319145,"EIF4B"]
["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Homo sapiens R-HSA-193368","1/24",0.05833855301300996,0.3923529135532057,0,0,17.68145519077196,50.24171555062859,"SLC27A5"]
["IKK complex recruitment mediated by RIP1 Homo sapiens R-HSA-937041","1/24",0.05833855301300996,0.3923529135532057,0,0,17.68145519077196,50.24171555062859,"SARM1"]
[]
[]
["Biocarta pathways"]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Hemoglobin's Chaperone Homo sapiens h ahspPathway","1/13",0.0358050737240218,0.1153124525629414,0,0,30.2,100.5559032787779,"HBA2"]
["IL12 and Stat4 Dependent Signaling Pathway in Th1 Development Homo sapiens h IL12Pathway","1/15",0.041200627604441056,0.1153124525629414,0,0,25.883116883116884,82.54907099640234,"IL18R1"]
["Bone Remodeling Homo sapiens h ranklPathway","1/16",0.043887273641335565,0.1153124525629414,0,0,24.156363636363636,75.5159546794018,"IRF9"]
["Map Kinase Inactivation of SMRT Corepressor Homo sapiens h egfr smrtePathway","1/17",0.04656652576934638,0.1153124525629414,0,0,22.645454545454545,69.45074052559761,"MAP2K4"]
["TNFR1 Signaling Pathway Homo sapiens h tnfr1Pathway","1/17",0.04656652576934638,0.1153124525629414,0,0,22.645454545454545,69.45074052559761,"MAP2K4"]
["FAS signaling pathway ( CD95 ) Homo sapiens h fasPathway","1/20",0.054560117949919246,0.1153124525629414,0,0,19.066985645933013,55.45541451142644,"MAP2K4"]
["EGF Signaling Pathway Homo sapiens h egfPathway","1/20",0.054560117949919246,0.1153124525629414,0,0,19.066985645933013,55.45541451142644,"MAP2K4"]
["NF-kB Signaling Pathway Homo sapiens h nfkbPathway","1/21",0.05720999346183073,0.1153124525629414,0,0,18.112727272727273,51.82099606513529,"IL1R1"]
["Inhibition of Cellular Proliferation by Gleevec Homo sapiens h gleevecpathway","1/22",0.05985257433019706,0.1153124525629414,0,0,17.24935064935065,48.57194341390608,"MAP2K4"]

{"sheet":"RA_down_enriched_pathways","index":2,"n_rows":102,"n_cols":11,"rows_kept":102,"merged":[[0,0,0,8],[2,0,2,8],[11,0,11,8],[77,0,77,8]],"flags":["formulas_cached_only"]}
["RA_down"]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["KEGG Pathways"]
[]
["Ribosome","14/153",7.421674170584641e-14,7.644324395702179e-12,0,0,21.627306850172037,653.8321263079778,"RPL5;RPL32;RPS8;RPLP1;RPL12;MRPS2;RPS28;RPL38;RPL37;MRPL9;RPS2;RPS11;RPL28;RPL19"]
["RNA transport","6/165",0.00024864970790234583,0.012805459956970808,0,0,7.447169811320754,61.807528531007655,"EIF4A2;EIF2S3;PABPC1;RPP14;EIF3C;EIF4B"]
["Spliceosome","4/134",0.00565116487117424,0.1940233272436489,0,0,5.9619909502262445,30.858630702283325,"TCERG1;DDX42;LSM4;SNRPB"]
["D-Glutamine and D-glutamate metabolism","1/5",0.02622300558108204,0.6656529917335485,0,0,47.357142857142854,172.43295370979877,"GLUD1"]
["Legionellosis","2/55",0.03444134101811995,0.6656529917335485,0,0,7.199201741654572,24.250494237710036,"EEF1G;TNF"]
["mTOR signaling pathway","3/152",0.04710920962859817,0.6656529917335485,0,0,3.8597119958298043,11.792526972005088,"WDR59;TNF;EIF4B"]
[]
["Reactome pathways"]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827","17/106",7.14413562674324e-21,9.573141739835939e-19,0,0,42.505365484156044,1971.7386868557876,"EIF4A2;RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;EIF2S3;RPL38;RPL37;PABPC1;RPS2;RPS11;EIF3C;RPL28;EIF4B;RPL19"]
["3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279","17/106",7.14413562674324e-21,9.573141739835939e-19,0,0,42.505365484156044,1971.7386868557876,"EIF4A2;RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;EIF2S3;RPL38;RPL37;PABPC1;RPS2;RPS11;EIF3C;RPL28;EIF4B;RPL19"]
["Cap-dependent Translation Initiation Homo sapiens R-HSA-72737","17/114",2.630175248359663e-20,1.7622174164009745e-18,0,0,38.98401482682729,1757.5807179208377,"EIF4A2;RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;EIF2S3;RPL38;RPL37;PABPC1;RPS2;RPS11;EIF3C;RPL28;EIF4B;RPL19"]
["Eukaryotic Translation Initiation Homo sapiens R-HSA-72613","17/114",2.630175248359663e-20,1.7622174164009745e-18,0,0,38.98401482682729,1757.5807179208377,"EIF4A2;RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;EIF2S3;RPL38;RPL37;PABPC1;RPS2;RPS11;EIF3C;RPL28;EIF4B;RPL19"]
["Translation Homo sapiens R-HSA-72766","18/151",1.2315445283058953e-19,6.6010786717196e-18,0,0,30.391148325358852,1323.256359786755,"EIF4A2;RPL5;RPL32;RPS8;RPLP1;RPL12;EEF1G;RPS28;EIF2S3;RPL38;RPL37;PABPC1;RPS2;RPS11;EIF3C;RPL28;EIF4B;RPL19"]
["GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706","16/107",3.4839077497149355e-19,1.5561454615393377e-17,0,0,38.687179487179485,1644.2423524875335,"EIF4A2;RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;EIF2S3;RPL38;RPL37;RPS2;RPS11;EIF3C;RPL28;EIF4B;RPL19"]
["Selenocysteine synthesis Homo sapiens R-HSA-2408557","13/87",9.01169253974695e-16,3.4501908580745466e-14,0,0,37.439697762278406,1297.0174061628632,"RPL5;RPL32;RPS8;RPLP1;SECISBP2;RPL12;RPS28;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Eukaryotic Translation Elongation Homo sapiens R-HSA-156842","13/89",1.2275546667390375e-15,3.655385007622911e-14,0,0,36.45076400679117,1251.4915018329864,"RPL5;RPL32;RPS8;RPLP1;RPL12;EEF1G;RPS28;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956","13/89",1.2275546667390375e-15,3.655385007622911e-14,0,0,36.45076400679117,1251.4915018329864,"RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;RPL38;RPL37;PABPC1;RPS2;RPS11;RPL28;RPL19"]
["Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689","13/96",3.4187286659740343e-15,9.162192824810411e-14,0,0,33.36481409509004,1111.3655302759046,"RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;RPL38;RPL37;RPS2;RPS11;EIF3C;RPL28;RPL19"]
["Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802","13/106",1.2906695955721817e-14,2.882495430111206e-13,0,0,29.762169036882877,951.8248253537924,"RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;RPL38;RPL37;PABPC1;RPS2;RPS11;RPL28;RPL19"]
["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957","13/106",1.2906695955721817e-14,2.882495430111206e-13,0,0,29.762169036882877,951.8248253537924,"RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;RPL38;RPL37;PABPC1;RPS2;RPS11;RPL28;RPL19"]
["Viral mRNA Translation Homo sapiens R-HSA-192823","12/84",2.1315639706297597e-14,4.0804224580626834e-13,0,0,35.145390070921984,1106.3535194558444,"RPL5;RPS28;RPL32;RPS8;RPLP1;RPL12;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Peptide chain elongation Homo sapiens R-HSA-156902","12/84",2.1315639706297597e-14,4.0804224580626834e-13,0,0,35.145390070921984,1106.3535194558444,"RPL5;RPS28;RPL32;RPS8;RPLP1;RPL12;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Selenoamino acid metabolism Homo sapiens R-HSA-2408522","13/111",2.383572798089098e-14,4.2586500659191885e-13,0,0,28.236559139784948,885.7128316860009,"RPL5;RPL32;RPS8;SECISBP2;RPLP1;RPL12;RPS28;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Eukaryotic Translation Termination Homo sapiens R-HSA-72764","12/87",3.3025418535817775e-14,5.531757604749477e-13,0,0,33.734468085106386,1047.1684529870618,"RPL5;RPS28;RPL32;RPS8;RPLP1;RPL12;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226","14/166",2.3088480223345406e-13,3.639830999915629e-12,0,0,19.7645881006865,575.0874035199147,"RPL5;RPL32;RPS8;IMP3;RPLP1;RPL12;RPS28;RPL38;RPL37;RPS2;RPS11;RPP14;RPL28;RPL19"]
["SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339","12/107",4.2305279413664403e-13,6.298786046034477e-12,0,0,26.605599104143337,758.0275580747982,"RPL5;RPS28;RPL32;RPS8;RPLP1;RPL12;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["rRNA processing Homo sapiens R-HSA-72312","14/180",7.062566598318024e-13,9.961936043943316e-12,0,0,18.084861183865897,505.9926721820884,"RPL5;RPL32;RPS8;IMP3;RPLP1;RPL12;RPS28;RPL38;RPL37;RPS2;RPS11;RPP14;RPL28;RPL19"]
["Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273","12/128",3.69527410951372e-12,4.951667306748385e-11,0,0,21.76595744680851,572.9663320665472,"RPL5;RPS28;RPL32;RPS8;RPLP1;RPL12;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Influenza Life Cycle Homo sapiens R-HSA-168255","12/136",7.628571449489804e-12,9.735510230777464e-11,0,0,20.353466026080987,521.0308297255683,"RPL5;RPS28;RPL32;RPS8;RPLP1;RPL12;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Translation initiation complex formation Homo sapiens R-HSA-72649","9/57",1.699685749770244e-11,2.0705262769928427e-10,0,0,38.36211340206186,951.3034058772843,"EIF4A2;RPS28;EIF2S3;RPS8;PABPC1;RPS2;RPS11;EIF3C;EIF4B"]
["Influenza Infection Homo sapiens R-HSA-168254","12/147",1.9215031793823165e-11,2.2367891045816712e-10,0,0,18.68463356973995,461.0494663265874,"RPL5;RPS28;RPL32;RPS8;RPLP1;RPL12;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Activation of the mRNA upon binding of the cap-binding complex and eIFs"," and subsequent binding to 43S Homo sapiens R-HSA-72662","9/58",2.003094720520899e-11,2.2367891045816712e-10,0,0,37.577319587628864,925.6700212522143,"EIF4A2;RPS28;EIF2S3;RPS8;PABPC1;RPS2;RPS11;EIF3C;EIF4B"]
["Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702","8/57",6.344688691064315e-10,6.801506276820948e-09,0,0,33.06122448979592,700.178311993806,"EIF4A2;RPS28;EIF2S3;RPS8;RPS2;RPS11;EIF3C;EIF4B"]
["Gene Expression Homo sapiens R-HSA-74160","30/1631",8.62175453761852e-10,8.887039292622167e-09,0,0,4.5102567474275945,94.1361047981533,"EIF4A2;RPL5;RPL32;DHX9;RPLP1;RPL12;ZNRD1;MED10;NARS2;RPL38;ZNF689;RPL37;RPS2;RPS11;RPP14;EIF4B;RPL19;TGIF2;RPS8;IMP3;LSM4;EEF1G;RPS28;EIF2S3;TRMT12;TCEA1;PABPC1;EIF3C;RPL28;SNRPB"]
["Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291","14/335",2.753220150740088e-09,2.7328259274012728e-08,0,0,9.278816199376948,182.89005702280417,"RPL5;RPL32;RPS8;SECISBP2;RPLP1;RPL12;GLUD1;RPS28;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Infectious disease Homo sapiens R-HSA-5663205","14/348",4.480631994433742e-09,4.288604908958009e-08,0,0,8.911741733923458,171.3148826419117,"RPL5;RPL32;RPS8;RPLP1;RPL12;RPS28;NMT2;TCEA1;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Metabolism of proteins Homo sapiens R-HSA-392499","23/1074",7.62190868473986e-09,7.04369492244925e-08,0,0,4.96817718065411,92.86635532991363,"EIF4A2;RPL5;RPL32;RPS8;CETN2;RPLP1;RPL12;TIMM9;TIMM44;EEF1G;RPS28;EIF2S3;SCMH1;RPL38;RPL37;PABPC1;CCT8;RPS2;RPS11;EIF3C;RPL28;EIF4B;RPL19"]
["Formation of the ternary complex"," and subsequently"," the 43S complex Homo sapiens R-HSA-72695","6/50",2.526472695634988e-07,2.2569822747672556e-06,0,0,27.068181818181817,411.20009934854346,"RPS28;EIF2S3;RPS8;RPS2;RPS11;EIF3C"]
["Disease Homo sapiens R-HSA-1643685","15/725",6.428284108112867e-06,5.5573552934653174e-05,0,0,4.453799721405355,53.24429788133389,"RPL5;RPL32;RPS8;DHH;RPLP1;RPL12;RPS28;NMT2;TCEA1;RPL38;RPL37;RPS2;RPS11;RPL28;RPL19"]
["Deadenylation-dependent mRNA decay Homo sapiens R-HSA-429914","4/50",0.00014229975829732971,0.001191760475740136,0,0,16.92071611253197,149.87650781418893,"EIF4A2;PABPC1;LSM4;EIF4B"]
["Deadenylation of mRNA Homo sapiens R-HSA-429947","3/23",0.000237223934623792,0.001926545893308371,0,0,28.94271844660194,241.5705729135497,"EIF4A2;PABPC1;EIF4B"]
["Signaling by TGF-beta Receptor Complex Homo sapiens R-HSA-170834","4/73",0.0006126087875460575,0.004828798678304218,0,0,11.267405512929809,83.35383243910519,"PPP1R15A;TGIF2;ARHGEF18;F11R"]
["Metabolism Homo sapiens R-HSA-1430728","21/1908",0.0009410323493520802,0.007205619132181642,0,0,2.3575984288787057,16.429002549846405,"RPL5;RPL32;RPS8;SECISBP2;RPLP1;RPL12;PLD4;GLUD1;RPS28;NDUFS8;MED10;LIPG;RPL38;RPL37;RPS2;PTGDS;RPS11;RPL28;ISCU;LGMN;RPL19"]
["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Homo sapiens R-HSA-2173791","2/16",0.003181041206578089,0.023681084537859113,0,0,27.307692307692307,157.03416022129693,"ARHGEF18;F11R"]
["Mitochondrial translation initiation Homo sapiens R-HSA-5368286","3/84",0.010106303265558643,0.06944844295306965,0,0,7.124415677813736,32.73381151982912,"MRPL41;MRPS25;MRPL9"]
["Mitochondrial translation termination Homo sapiens R-HSA-5419276","3/84",0.010106303265558643,0.06944844295306965,0,0,7.124415677813736,32.73381151982912,"MRPL41;MRPS25;MRPL9"]
["Mitochondrial translation elongation Homo sapiens R-HSA-5389840","3/84",0.010106303265558643,0.06944844295306965,0,0,7.124415677813736,32.73381151982912,"MRPL41;MRPS25;MRPL9"]
["Mitochondrial translation Homo sapiens R-HSA-5368287","3/90",0.012179929684333306,0.08160552888503315,0,0,6.631067961165049,29.22952072239107,"MRPL41;MRPS25;MRPL9"]
["Rho GTPase cycle Homo sapiens R-HSA-194840","3/122",0.02712384623644169,0.17729733637478953,0,0,4.8400913763563675,17.45986492071536,"ARHGAP32;ARHGEF18;RHOF"]
["Organelle biogenesis and maintenance Homo sapiens R-HSA-1852241","5/326",0.029798266776400774,0.19014132133512882,0,0,3.0185682119613833,10.605150939919323,"MRPL41;MRPS25;CETN2;MRPL9;CCT8"]
["Synthesis of wybutosine at G37 of tRNA(Phe) Homo sapiens R-HSA-6782861","1/6",0.031385296805751035,0.19116498963502898,0,0,37.883809523809525,131.13161496811227,"TRMT12"]
["TNFR1-mediated ceramide production Homo sapiens R-HSA-5626978","1/6",0.031385296805751035,0.19116498963502898,0,0,37.883809523809525,131.13161496811227,"TNF"]
["Mitochondrial protein import Homo sapiens R-HSA-1268020","2/54",0.033301940560472594,0.19833155711570338,0,0,7.33801775147929,24.964960840949878,"TIMM9;TIMM44"]
["mRNA Splicing - Major Pathway Homo sapiens R-HSA-72163","3/134",0.034433133801844894,0.2006104317150963,0,0,4.394056177277107,14.802415170043075,"DHX9;LSM4;SNRPB"]
["Vitamin D (calciferol) metabolism Homo sapiens R-HSA-196791","1/7",0.036520479588945484,0.2082444368050508,0,0,31.56825396825397,104.48719845726775,"LGMN"]
["rRNA modification in the nucleus Homo sapiens R-HSA-6790901","2/58",0.03794908409148872,0.21049981409366358,0,0,6.8125,22.28716126217046,"IMP3;RPS2"]
["mRNA Splicing Homo sapiens R-HSA-72172","3/144",0.0412253697255301,0.21049981409366358,0,0,4.080355298492047,13.011034824574196,"DHX9;LSM4;SNRPB"]
["Release of Hh-Np from the secreting cell Homo sapiens R-HSA-5362798","1/8",0.04162869457822453,0.21049981409366358,0,0,27.057142857142857,86.01372572734715,"DHH"]
["Ligand-receptor interactions Homo sapiens R-HSA-5632681","1/8",0.04162869457822453,0.21049981409366358,0,0,27.057142857142857,86.01372572734715,"DHH"]
["Synthesis of PG Homo sapiens R-HSA-1483148","1/8",0.04162869457822453,0.21049981409366358,0,0,27.057142857142857,86.01372572734715,"PLD4"]
["Recycling of eIF2:GDP Homo sapiens R-HSA-72731","1/8",0.04162869457822453,0.21049981409366358,0,0,27.057142857142857,86.01372572734715,"EIF2S3"]
["Mitochondrial iron-sulfur cluster biogenesis Homo sapiens R-HSA-1362409","1/9",0.04671008178648439,0.2318204059032929,0,0,23.673809523809524,72.5317052519737,"ISCU"]
["Folding of actin by CCT/TriC Homo sapiens R-HSA-390450","1/10",0.05176478059643375,0.24773144999721866,0,0,21.04232804232804,62.30728596638391,"CCT8"]
["SLBP independent Processing of Histone Pre-mRNAs Homo sapiens R-HSA-111367","1/10",0.05176478059643375,0.24773144999721866,0,0,21.04232804232804,62.30728596638391,"SNRPB"]
["Membrane binding and targetting of GAG proteins Homo sapiens R-HSA-174490","1/11",0.05679292971226178,0.2579746637777315,0,0,18.937142857142856,54.31822944685532,"NMT2"]
["Synthesis And Processing Of GAG"," GAGPOL Polyproteins Homo sapiens R-HSA-174495","1/11",0.05679292971226178,0.2579746637777315,0,0,18.937142857142856,54.31822944685532,"NMT2"]
["SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Homo sapiens R-HSA-77588","1/11",0.05679292971226178,0.2579746637777315,0,0,18.937142857142856,54.31822944685532,"SNRPB"]
[]
[]
["Biocarta pathways"]
[]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Eukaryotic protein translation Homo sapiens h eifPathway","2/14",0.0024290159012020714,0.0510093339252435,0,0,31.862179487179485,191.81889407044008,"EIF4A2;EIF2S3"]
["Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway Homo sapiens h igf1mtorpathway","2/25",0.007709644419990716,0.08095126640990252,0,0,16.61454849498328,80.8344838642323,"EIF2S3;PABPC1"]
["Visceral Fat Deposits and the Metabolic Syndrome Homo sapiens h vobesityPathway","1/8",0.04162869457822453,0.1797070574246123,0,0,27.057142857142857,86.01372572734715,"TNF"]
["SODD/TNFR1 Signaling Pathway Homo sapiens h soddPathway","1/9",0.04671008178648439,0.1797070574246123,0,0,23.673809523809524,72.5317052519737,"TNF"]
["Regulation of eIF2 Homo sapiens h eif2Pathway","1/11",0.05679292971226178,0.1797070574246123,0,0,18.937142857142856,54.31822944685532,"EIF2S3"]
["IL-10 Anti-inflammatory Signaling Pathway Homo sapiens h il10Pathway","1/13",0.06677013024916706,0.1797070574246123,0,0,15.77936507936508,42.70684291496826,"TNF"]
["Double Stranded RNA Induced Gene Expression Homo sapiens h rnaPathway","1/14",0.07171945564755952,0.1797070574246123,0,0,14.564835164835165,38.37824191326997,"EIF2S3"]
["Stress Induction of HSP Regulation Homo sapiens h hsp27Pathway","1/14",0.07171945564755952,0.1797070574246123,0,0,14.564835164835165,38.37824191326997,"TNF"]
["Cadmium induces DNA synthesis and proliferation in macrophages Homo sapiens h cdMacPathway","1/16",0.08154023643974266,0.1797070574246123,0,0,12.6215873015873,31.638011389100345,"TNF"]
["TNFR1 Signaling Pathway Homo sapiens h tnfr1Pathway","1/17",0.08641196167957486,0.1797070574246123,0,0,11.832142857142857,28.97253011271759,"TNF"]
["NF-kB Signaling Pathway Homo sapiens h nfkbPathway","1/21",0.10564421088252372,0.1797070574246123,0,0,9.463809523809523,21.271599601670488,"TNF"]
["TNF/Stress Related Signaling Homo sapiens h stressPathway","1/23",0.11510939254477758,0.1797070574246123,0,0,8.602597402597402,18.59771757676144,"TNF"]
["mTOR Signaling Pathway Homo sapiens h mTORPathway","1/24",0.11980470494974153,0.1797070574246123,0,0,8.228157349896481,17.45926389427172,"EIF4B"]
["Regulation of eIF4e and p70 S6 Kinase Homo sapiens h eif4Pathway","1/24",0.11980470494974153,0.1797070574246123,0,0,8.228157349896481,17.45926389427172,"PABPC1"]
["NFkB activation by Nontypeable Hemophilus influenzae Homo sapiens h nthiPathway","1/29",0.1429136286904142,0.20007908016657985,0,0,6.757142857142857,13.146121612489974,"TNF"]
["Ceramide Signaling Pathway Homo sapiens h ceramidePathway","1/33",0.1609672024230657,0.2112694531802737,0,0,5.911309523809524,10.79732987706831,"TNF"]
["Signal transduction through IL1R Homo sapiens h il1rPathway","1/36",0.17425970165143273,0.2152619843929464,0,0,5.403809523809524,9.441582225640868,"TNF"]
["NFAT and Hypertrophy of the heart Homo sapiens h nfatPathway","1/44",0.20869517162400106,0.24347770022800125,0,0,4.3966777408637885,6.889069059482109,"TNF"]
["Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa Homo sapiens h pparaPathway","1/52",0.24170758039791693,0.2457370008212327,0,0,3.7055088702147527,5.261921269428735,"TNF"]
["HIV-1 Nef: negative effector of Fas and TNF Homo sapiens h HivnefPathway","1/53",0.2457370008212327,0.2457370008212327,0,0,3.634065934065934,5.100387616495913,"TNF"]
["Keratinocyte Differentiation Homo sapiens h keratinocytePathway","1/53",0.2457370008212327,0.2457370008212327,0,0,3.634065934065934,5.100387616495913,"TNF"]

{"sheet":"SLE_up_enriched_pathways","index":3,"n_rows":349,"n_cols":11,"rows_kept":349,"merged":[[2,0,2,8],[59,0,59,8],[337,0,337,8]],"flags":["formulas_cached_only"]}
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
[]
["KEGG Pathways"]
["Influenza A","25/171",2.278172294662683e-11,5.1714511088842915e-09,0,0,6.013424158494898,147.35933500282042,"ADAR;IFIH1;TNFSF10;TRIM25;CCL2;JAK2;RSAD2;DDX58;STAT1;IFNGR2;STAT2;MX1;EIF2AK2;TICAM1;PML;NFKBIA;CXCL10;OAS1;OAS2;OAS3;IRF7;FAS;TLR7;MYD88;IRF9"]
["Necroptosis","20/162",4.380212445820377e-08,4.8430183469192886e-06,0,0,4.902628769003915,83.06810000109381,"ZBP1;HIST2H2AA3;TICAM2;HIST2H2AA4;PARP4;MLKL;H2AFY;STAT1;IFNGR2;STAT2;HIST1H2AJ;STAT3;EIF2AK2;TICAM1;TNFSF10;FAS;JAK2;HIST1H2AC;IRF9;CHMP5"]
["Epstein-Barr virus infection","22/201",8.373858787487184e-08,4.8430183469192886e-06,0,0,4.285422233017569,69.83338057762283,"CDKN1A;GADD45A;STAT1;DDX58;STAT2;STAT3;EIF2AK2;TAP1;ISG15;GADD45G;SAP30;NFKBIA;CCNA2;CXCL10;OAS1;OAS2;OAS3;IRF7;FAS;MYD88;IRF9;TLR2"]
["Measles","18/138",8.856315317291703e-08,4.8430183469192886e-06,0,0,5.208453237410072,84.58293648119218,"DDX58;STAT1;STAT2;MX1;STAT3;EIF2AK2;ADAR;NFKBIA;IFIH1;OAS1;OAS2;OAS3;IRF7;FAS;TLR7;MYD88;IRF9;TLR2"]
["Hepatitis C","19/155",1.0667441292773762e-07,4.8430183469192886e-06,0,0,4.855723370429253,77.95127991814921,"CDKN1A;RSAD2;DDX58;STAT1;STAT2;MX1;STAT3;EIF2AK2;CLDN2;IFIT1;TICAM1;NFKBIA;CXCL10;OAS1;OAS2;OAS3;IRF7;FAS;IRF9"]
["Systemic lupus erythematosus","17/133",2.712381596181794e-07,1.0261843705554457e-05,0,0,5.080635176128274,76.82056844150402,"HIST2H2AA3;C1QB;HIST2H2AA4;HIST1H2BO;H2AFY;HIST1H2AJ;HIST1H2BK;HIST2H2BE;HIST1H2BF;HIST1H2BE;HIST1H2BH;CTSG;TRIM21;HIST1H2AC;HIST1H2BD;HIST1H2BC;C1QC"]
["NOD-like receptor signaling pathway","19/178",9.353643547592929e-07,3.0332529790051364e-05,0,0,4.148371012521956,57.58905411097474,"STAT1;DEFA4;STAT2;TXN;NOD2;TICAM1;NFKBIA;AIM2;OAS1;IFI16;OAS2;OAS3;IRF7;CCL2;CARD16;GBP1;MYD88;CAMP;IRF9"]
["Hepatitis B","18/163",1.0980497638079715e-06,3.115716204805119e-05,0,0,4.304862317042917,59.07121263518823,"EGR2;CDKN1A;TICAM2;DDX58;STAT1;STAT2;STAT3;TICAM1;MMP9;NFKBIA;IFIH1;CCNA2;IRF7;BIRC5;FAS;JAK2;MYD88;TLR2"]
["Viral carcinogenesis","20/201",1.4811429614614273e-06,3.7357716916860446e-05,0,0,3.838482557791651,51.522786382183206,"EGR2;CDKN1A;SP100;HIST1H2BO;STAT3;HIST1H2BK;EIF2AK2;HIST2H2BE;CDC20;NFKBIA;CCNA2;CHEK1;HIST1H2BF;CDK1;IRF7;HIST1H2BE;HIST1H2BH;HIST1H2BD;IRF9;HIST1H2BC"]
["Toll-like receptor signaling pathway","13/104",8.780704190928212e-06,0.00019932198513407045,0,0,4.923605805958747,57.325315664540604,"TICAM2;STAT1;LY96;TICAM1;NFKBIA;CXCL10;IRF7;CCL3;TLR7;CD14;TLR5;MYD88;TLR2"]
["p53 signaling pathway","10/72",3.7963858194190146e-05,0.0007834359827346512,0,0,5.537634408602151,56.366893707003904,"CCNB2;CDKN1A;CCNB1;RRM2;GADD45A;CHEK1;SHISA5;CDK1;FAS;GADD45G"]
["Cell cycle","13/124",5.843681858497596e-05,0.001105429818232462,0,0,4.032294326411973,39.30504867307391,"CDKN1A;GADD45A;BUB1B;RBX1;GADD45G;CDC20;CCNA2;CCNB2;CCNB1;PTTG1;CHEK1;CDK1;MCM4"]
["Mineral absorption","8/51",9.40555215552009e-05,0.0016423541071562003,0,0,6.371271263045443,59.072039805158,"MT2A;VDR;MT1F;MT1X;MT1H;ATOX1;MT1HL1;MT1E"]
["Human immunodeficiency virus 1 infection","17/212",0.00014005995969294585,0.002270972203592765,0,0,3.009961791649404,26.70871519049427,"LIMK2;TAP1;TNFRSF1B;RBX1;BST2;NFKBIA;CCNB2;CCNB1;GNG5;APOBEC3A_B;CHEK1;CDK1;FAS;APOBEC3A;MYD88;APOBEC3B;TLR2"]
["Chagas disease (American trypanosomiasis)","11/103",0.00018135105595959292,0.002744445980188506,0,0,4.105992740752182,35.37343898111794,"NFKBIA;C1QB;GNA15;IFNGR2;CCL3;CCL2;FAS;TICAM1;MYD88;TLR2;C1QC"]
["Pertussis","9/76",0.00031946712344598746,0.004532439813889946,0,0,4.6025888257825915,37.04557555791117,"C1QB;CASP7;TICAM2;SERPING1;LY96;CD14;TICAM1;MYD88;C1QC"]
["Cytosolic DNA-sensing pathway","8/63",0.0004233155453682818,0.0056525075763882325,0,0,4.978091872791519,38.66679440732588,"ZBP1;NFKBIA;CXCL10;AIM2;DDX58;TREX1;IRF7;ADAR"]
["Alcoholism","14/180",0.0007181440724853709,0.009056594691898841,0,0,2.9006024096385543,20.99699776506333,"HIST2H2AA3;HIST2H2AA4;HIST1H2BO;H2AFY;HIST1H2AJ;HIST1H2BK;HIST2H2BE;GNG5;HIST1H2BF;HIST1H2BE;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST1H2BC"]
["RIG-I-like receptor signaling pathway","8/70",0.0008661583060649774,0.009909355067595035,0,0,4.414453436680725,31.12826618739995,"IFIH1;NFKBIA;CXCL10;DDX58;DHX58;IRF7;TRIM25;ISG15"]
["Apoptosis","12/143",0.0008730709310656419,0.009909355067595035,0,0,3.144983836353264,22.151674012931732,"NFKBIA;CASP7;PARP4;GADD45A;CTSL;TNFSF10;BIRC5;FAS;CSF2RB;CTSD;GADD45G;LMNB1"]
["TNF signaling pathway","10/110",0.0012583933098105266,0.013602632444142362,0,0,3.426595744680851,22.882530619666362,"NFKBIA;CXCL10;CASP7;MLKL;IL15;CCL2;FAS;NOD2;TNFRSF1B;MMP9"]
["NF-kappa B signaling pathway","9/95",0.001631049060420765,0.016829460759796078,0,0,3.58221856349043,22.992584035960338,"NFKBIA;TICAM2;DDX58;TRIM25;LY96;CD14;TICAM1;MYD88;TNFSF13B"]
["Proteasome","6/45",0.0017126374375631501,0.016902986883775437,0,0,5.251083423618635,33.44793496745754,"PSMA4;POMP;PSME1;PSME2;PSMB8;PSMB9"]
["Kaposi sarcoma-associated herpesvirus infection","13/186",0.0028485319891965472,0.02694236506448401,0,0,2.578889884908246,15.114748562283168,"CCR1;CDKN1A;STAT1;STAT2;STAT3;EIF2AK2;TICAM1;NFKBIA;GNG5;IRF7;FAS;JAK2;IRF9"]
["Legionellosis","6/55",0.004791496248152623,0.043506785933225815,0,0,4.177277953434895,22.310476234651702,"NFKBIA;CASP7;CD14;TLR5;MYD88;TLR2"]
["Pyrimidine metabolism","6/57",0.005716935976438364,0.0499132487173657,0,0,4.0130488815244405,20.724677771925847,"RRM2;CMPK2;TK1;UPP1;TYMS;TYMP"]
["JAK-STAT signaling pathway","11/162",0.0071910059103302715,0.060457716357221164,0,0,2.494030324773858,12.307850637571857,"IL15RA;CDKN1A;CISH;IL15;STAT1;IFNGR2;STAT2;STAT3;CSF2RB;JAK2;IRF9"]
["Lysosome","9/123",0.009062029967721685,0.07346717152402936,0,0,2.6984629715882633,12.692658077271702,"CD63;GM2A;CTSL;SORT1;GLB1;LAMP3;NEU1;CTSG;CTSD"]
["Inflammatory bowel disease (IBD)","6/65",0.010747779909286648,0.08412917377269205,0,0,3.467474337550728,15.718255578850668,"STAT1;IFNGR2;STAT3;NOD2;TLR5;TLR2"]
["Staphylococcus aureus infection","6/68",0.013259967802727996,0.10033375637397517,0,0,3.2991821899136755,14.262383486163065,"C1QB;DEFA4;C3AR1;FPR2;CAMP;C1QC"]
["Tuberculosis","11/179",0.014503012722484976,0.10619948025819642,0,0,2.2396811300008457,9.481463580971468,"RAB5C;VDR;STAT1;IFNGR2;CD14;NOD2;JAK2;CTSD;MYD88;CAMP;TLR2"]
["Herpes simplex virus 1 infection","23/492",0.0155863306237778,0.11056553286242377,0,0,1.6872250105448903,7.021152341780452,"SP100;STAT1;DDX58;IFNGR2;STAT2;EIF2AK2;TAP1;TICAM1;PML;IFIH1;BST2;NFKBIA;OAS1;OAS2;OAS3;IRF7;CCL2;FAS;JAK2;MYD88;IRF9;SRSF9;TLR2"]
["Toxoplasmosis","8/113",0.016198150748031333,0.11142364302433673,0,0,2.600841325929665,10.722899973504155,"NFKBIA;STAT1;IFNGR2;STAT3;LY96;JAK2;MYD88;TLR2"]
["Leishmaniasis","6/74",0.019462665258065802,0.12994191216414522,0,0,3.007145816072908,11.845920960047042,"NFKBIA;STAT1;IFNGR2;JAK2;MYD88;TLR2"]
["Chemokine signaling pathway","11/190",0.0215851103923536,0.1399948588304076,0,0,2.1008464232910287,8.058324894364423,"CCR1;NFKBIA;CXCL10;GNG5;STAT1;STAT2;STAT3;CCL3;CCL2;CXCL13;JAK2"]
["Human T-cell leukemia virus 1 infection","12/219",0.024710166619528087,0.15581132840646877,0,0,1.9824642838722988,7.336189404001149,"CDC20;NFKBIA;CCNA2;IL15RA;EGR1;CCNB2;EGR2;CDKN1A;PTTG1;IL15;CHEK1;BUB1B"]
["Complement and coagulation cascades","6/79",0.02594589489239013,0.15918157136682592,0,0,2.800453405363689,10.226532968948396,"C1QB;C3AR1;SERPING1;CD59;F5;C1QC"]
["Drug metabolism","7/108",0.036032205619321946,0.2134376509417737,0,0,2.3621806625106956,7.85033453779257,"RRM2;NAT1;GSTO1;TK1;UPP1;MPO;TYMP"]
["FoxO signaling pathway","8/132",0.03666990478735319,0.2134376509417737,0,0,2.2001595805311753,7.2732851065678785,"CCNB2;CCNB1;CDKN1A;GADD45A;STAT3;TNFSF10;PCK2;GADD45G"]
["Central carbon metabolism in cancer","5/65",0.0386476648893664,0.2193254982471543,0,0,2.8362624487404804,9.227124480847085,"LDHA;SCO2;PGAM1;IDH1;PFKP"]
["Cellular senescence","9/160",0.041563836300702296,0.22972526899335619,0,0,2.0333470081462814,6.467110605705558,"CCNA2;CCNB2;CCNB1;CDKN1A;GADD45A;CHEK1;CDK1;FOXM1;GADD45G"]
["Transcriptional misregulation in cancer","10/186",0.042571011938815594,0.22972526899335619,0,0,1.93927304964539,6.121473874602275,"ETV7;CDKN1A;GADD45A;LMO2;TFE3;CD14;MPO;MMP9;PML;GADD45G"]
["Ubiquitin mediated proteolysis","8/137",0.04409003770679451,0.22972526899335619,0,0,2.114334237269565,6.599939619956913,"CDC20;UBE2C;FANCL;UBE2L6;BRCA1;PML;RBX1;UBE2J1"]
["Sphingolipid metabolism","4/47",0.045371216373909964,0.22972526899335619,0,0,3.16328029375765,9.783638053158496,"UGCG;SPTLC2;GLB1;NEU1"]
["Glycolysis / Gluconeogenesis","5/68",0.04554025156255959,0.22972526899335619,0,0,2.700783887075627,8.34315002637568,"LDHA;PGAM1;GALM;PFKP;PCK2"]
["Rheumatoid arthritis","6/91",0.046927421724103593,0.23104126455210997,0,0,2.4036039768019886,7.352992531430436,"CTSL;IL15;CCL3;CCL2;TNFSF13B;TLR2"]
["Adipocytokine signaling pathway","5/69",0.04799015868598156,0.23104126455210997,0,0,2.6584468365553597,8.073063198251328,"NFKBIA;STAT3;JAK2;TNFRSF1B;PCK2"]
["Protein processing in endoplasmic reticulum","9/165",0.04885454052203205,0.23104126455210997,0,0,1.967665078284547,5.940199760683131,"DNAJA1;SEC61G;EIF2AK2;FBXO6;SIL1;PDIA6;RBX1;UBE2J1;TXNDC5"]
["Small cell lung cancer","6/93",0.05121203890311948,0.23724760879608414,0,0,2.348105876639145,6.978055584279375,"NFKBIA;CDKN1A;GADD45A;CKS2;CKS1B;GADD45G"]
["Nicotinate and nicotinamide metabolism","3/30",0.053833130831946095,0.2426010757268769,0,0,3.7748589219692548,11.029632643401621,"BST1;NAPRT;CD38"]
["Pathways in cancer","22/530",0.0545050874981089,0.2426010757268769,0,0,1.484209174940089,4.318249056270572,"IL15RA;CDKN1A;GSTO1;STAT1;GADD45A;IL15;IFNGR2;STAT2;STAT3;CSF2RB;MMP9;PML;RBX1;GADD45G;CKS1B;NFKBIA;CASP7;GNG5;CKS2;BIRC5;FAS;JAK2"]
["Amoebiasis","6/96",0.058073463119635335,0.24539860804941627,0,0,2.2694835680751173,6.459055684917819,"SERPINB1;GNA15;RAB5C;CTSG;CD14;TLR2"]
["Galactose metabolism","3/31",0.058376761386204755,0.24539860804941627,0,0,3.639854891168376,10.340235868309597,"GLB1;GALM;PFKP"]
["Mucin type O-glycan biosynthesis","3/31",0.058376761386204755,0.24539860804941627,0,0,3.639854891168376,10.340235868309597,"GALNT14;C1GALT1C1;B4GALT5"]
[]
[]
["Reactome pathways"]
[]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Interferon Signaling Homo sapiens R-HSA-913531","45/196",6.615927050125126e-28,5.200118661398349e-25,0,0,10.858611149363412,679.5634047186304,"IFITM3;IFITM1;SP100;IFITM2;IFI6;UBE2L6;ADAR;IFI35;IFI30;IFIT1;USP18;IFIT3;IFIT2;OASL;HERC5;MT2A;TRIM6;TRIM25;JAK2;TRIM21;GBP1;FCGR1B;TRIM22;EGR1;RSAD2;STAT1;DDX58;IFNGR2;STAT2;MX2;MX1;EIF2AK2;ISG15;PSMB8;PML;BST2;ISG20;IFI27;OAS1;OAS2;OAS3;IRF7;TRIM14;XAF1;IRF9"]
["Interferon alpha/beta signaling Homo sapiens R-HSA-909733","28/68",1.1786171438999748e-25,4.631965375526901e-23,0,0,24.853846153846153,1426.617864644671,"IFITM3;IFITM1;IFITM2;IFI6;ADAR;IFI35;IFIT1;USP18;IFIT3;IFIT2;OASL;EGR1;RSAD2;STAT1;MX2;STAT2;MX1;ISG15;PSMB8;BST2;ISG20;OAS1;IFI27;OAS2;OAS3;IRF7;XAF1;IRF9"]
["Immune System Homo sapiens R-HSA-168256","113/1547",9.694631544306641e-21,2.5399934646083403e-18,0,0,3.0754438988676003,141.72480367392583,"IFITM3;IFITM1;IFITM2;UBE2L6;IFI35;IFIT1;IFI30;IFIT3;IFIT2;HERC5;CDC20;MT2A;CLEC5A;DHX58;C3AR1;TRIM25;FBXO6;LGALS9;TRIM21;TRIM22;HERC6;ZBP1;IL15RA;TICAM2;CISH;RSAD2;TAP1;TICAM1;RBX1;OSCAR;IFI27;PSME1;PSME2;TRIM14;KIF20A;LY96;CSF2RB;TXN;UBE2J1;CD14;EGR1;SIGLEC16;UBE2C;DEFA4;TREX1;EIF2AK2;ISG15;BST2;ISG20;NFKBIA;KIF18A;SELL;KIF4A;XAF1;MYD88;CDKN1A;ADAR;KIF11;TNFSF13B;KIF15;OASL;IGLV4-60;IFIH1;TRIM6;CTSL;SEC61G;TRIM69;JAK2;CTSD;CAMP;DUSP5;DTX3L;IL15;DDX58;IFNGR2;KIF23;TNFRSF1B;PSMA4;AIM2;OAS1;OAS2;OAS3;IRF7;BPI;KIF2C;TLR7;TLR5;IRF9;TLR2;LTF;C1QB;SP100;UNC93B1;IFI6;NOD2;LILRA3;USP18;IFI16;CD59;FCGR1B;GBP1;STAT1;STAT2;MX2;STAT3;MX1;PSMB8;PML;PSMB9;CENPE;CFHR3;SIGLEC1;C1QC"]
["Cell Cycle Homo sapiens R-HSA-1640170","60/566",1.8186023305494983e-18,3.573553579529764e-16,0,0,4.364743698189816,178.2930732847866,"HIST2H2AA3;TOP2A;CDKN1A;GMNN;HJURP;BUB1B;MCM10;BRCA1;FOXM1;CKS1B;LMNB1;CDC20;PTTG1;CHEK1;NEK2;RAB8A;HIST1H2AC;HIST1H2AJ;KIF23;VRK2;HIST2H2BE;CCNA2;PSMA4;PSME1;PSME2;BIRC5;MCM4;KIF2C;HIST1H2BH;KIF20A;MAPRE1;HIST1H2BD;HIST1H2BC;HIST1H2BO;CDCA5;HIST1H2BK;NCAPG;TYMS;CENPA;AURKB;CCNB2;CCNB1;RBBP8;ATRIP;GINS2;RRM2;UBE2C;MND1;PSMB8;NDC80;REC8;ZWINT;PSMB9;CENPE;TPX2;KIF18A;CDK1;CENPM;CENPN;SPC25"]
["Cell Cycle Mitotic Homo sapiens R-HSA-69278","53/462",6.590294200968816e-18,1.0359942483922978e-15,0,0,4.729953212038162,187.1213653443248,"HIST2H2AA3;TOP2A;CDKN1A;GMNN;BUB1B;MCM10;FOXM1;CKS1B;LMNB1;CDC20;PTTG1;NEK2;RAB8A;HIST1H2AC;HIST1H2AJ;KIF23;VRK2;HIST2H2BE;CCNA2;PSMA4;PSME1;PSME2;BIRC5;MCM4;KIF2C;HIST1H2BH;KIF20A;MAPRE1;HIST1H2BD;HIST1H2BC;HIST1H2BO;CDCA5;HIST1H2BK;NCAPG;TYMS;CENPA;AURKB;CCNB2;CCNB1;GINS2;RRM2;UBE2C;PSMB8;NDC80;ZWINT;PSMB9;CENPE;TPX2;KIF18A;CDK1;CENPM;CENPN;SPC25"]
["Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215","61/620",3.47447131706531e-17,4.551557425355556e-15,0,0,4.013317431922083,152.09872776005187,"IFITM3;IFITM1;IFITM2;UBE2L6;ADAR;IFI35;IFIT1;IFI30;IFIT3;TNFSF13B;IFIT2;OASL;HERC5;TRIM6;MT2A;TRIM25;LGALS9;JAK2;TRIM21;TRIM22;DUSP5;IL15RA;CISH;RSAD2;IL15;DDX58;IFNGR2;TNFRSF1B;RBX1;PSMA4;IFI27;OAS1;OAS2;OAS3;PSME1;IRF7;PSME2;TRIM14;IRF9;SP100;IFI6;CSF2RB;NOD2;USP18;FCGR1B;GBP1;EGR1;STAT1;STAT2;MX2;STAT3;MX1;EIF2AK2;ISG15;PSMB8;PML;PSMB9;BST2;ISG20;XAF1;MYD88"]
["M Phase Homo sapiens R-HSA-68886","39/268",6.049705102680168e-17,6.792954586723731e-15,0,0,6.110949679631066,228.20692017265372,"HIST2H2AA3;HIST1H2BO;CDCA5;HIST1H2BK;NCAPG;BUB1B;CENPA;AURKB;LMNB1;CDC20;CCNB2;CCNB1;PTTG1;HIST1H2AC;UBE2C;HIST1H2AJ;KIF23;VRK2;ZWINT;HIST2H2BE;PSMB8;NDC80;PSMB9;CENPE;KIF18A;PSMA4;PSME1;CDK1;PSME2;CENPM;BIRC5;KIF2C;CENPN;HIST1H2BH;KIF20A;MAPRE1;HIST1H2BD;SPC25;HIST1H2BC"]
["Interferon gamma signaling Homo sapiens R-HSA-877300","20/93",1.5670767482527514e-12,1.5396529051583282e-10,0,0,9.570743286682163,260.1501176903925,"SP100;STAT1;IFNGR2;IFI30;PML;OASL;TRIM6;MT2A;OAS1;OAS2;OAS3;IRF7;TRIM25;TRIM14;JAK2;TRIM21;GBP1;FCGR1B;TRIM22;IRF9"]
["Cell Cycle Checkpoints Homo sapiens R-HSA-69620","25/182",9.064305230329557e-11,7.91615990115448e-09,0,0,5.588910932442309,129.23848960220934,"CDKN1A;HIST1H2BO;HIST1H2BK;BUB1B;MCM10;BRCA1;CDC20;CCNB2;CCNB1;CHEK1;RBBP8;ATRIP;UBE2C;HIST2H2BE;PSMB8;PSMB9;CCNA2;PSMA4;PSME1;CDK1;PSME2;MCM4;HIST1H2BH;HIST1H2BD;HIST1H2BC"]
["Mitotic Anaphase Homo sapiens R-HSA-68882","24/173",1.7531364223384573e-10,1.2968458680342559e-08,0,0,5.64549115314216,126.82282271219673,"UBE2C;CDCA5;BUB1B;VRK2;CENPA;NDC80;ZWINT;AURKB;PSMB8;LMNB1;PSMB9;CDC20;CENPE;KIF18A;PSMA4;PTTG1;PSME1;PSME2;BIRC5;CENPM;KIF2C;CENPN;MAPRE1;SPC25"]
["Mitotic Prometaphase Homo sapiens R-HSA-68877","19/107",1.9363330217403217e-10,1.2968458680342559e-08,0,0,7.522972972972973,168.25170385656716,"CDCA5;BUB1B;NCAPG;CENPA;NDC80;ZWINT;AURKB;CDC20;CCNB2;CENPE;CCNB1;KIF18A;CDK1;BIRC5;CENPM;KIF2C;CENPN;MAPRE1;SPC25"]
["Mitotic Metaphase and Anaphase Homo sapiens R-HSA-2555396","24/174",1.9799173557774896e-10,1.2968458680342559e-08,0,0,5.607563636363636,125.28864940639602,"UBE2C;CDCA5;BUB1B;VRK2;CENPA;NDC80;ZWINT;AURKB;PSMB8;LMNB1;PSMB9;CDC20;CENPE;KIF18A;PSMA4;PTTG1;PSME1;PSME2;BIRC5;CENPM;KIF2C;CENPN;MAPRE1;SPC25"]
["Resolution of Sister Chromatid Cohesion Homo sapiens R-HSA-2500257","18/99",3.8914491762762404e-10,2.352830040425481e-08,0,0,7.731814548361311,167.52576165571853,"CDCA5;BUB1B;CENPA;NDC80;ZWINT;AURKB;CDC20;CCNB2;CENPE;CCNB1;KIF18A;CDK1;BIRC5;CENPM;KIF2C;CENPN;MAPRE1;SPC25"]
["DNA Damage/Telomere Stress Induced Senescence Homo sapiens R-HSA-2559586","14/59",8.905431585004714e-10,4.999763732724075e-08,0,0,10.767222222222221,224.3801848040589,"HIST2H2AA3;CDKN1A;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST2H2BE;LMNB1;CCNA2;H1F0;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST1H1C;HIST1H2BC"]
["RHO GTPase Effectors Homo sapiens R-HSA-195258","28/255",1.344042852101216e-09,7.042784545010372e-08,0,0,4.337286795436575,88.600289093913,"HIST2H2AA3;HIST1H2BO;HIST1H2BK;KIF14;BUB1B;CENPA;AURKB;CDC20;SRGAP2;HIST1H2AC;LIMK2;HIST1H2AJ;ZWINT;HIST2H2BE;NDC80;CENPE;KIF18A;FMNL1;PRC1;CENPM;BIRC5;KIF2C;CENPN;HIST1H2BH;MAPRE1;HIST1H2BD;SPC25;HIST1H2BC"]
["Separation of Sister Chromatids Homo sapiens R-HSA-2467813","22/162",1.526863626182934e-09,7.500717563623664e-08,0,0,5.490320910973085,111.45378968425294,"UBE2C;CDCA5;BUB1B;CENPA;NDC80;ZWINT;AURKB;PSMB8;PSMB9;CDC20;CENPE;KIF18A;PSMA4;PTTG1;PSME1;PSME2;BIRC5;CENPM;KIF2C;CENPN;MAPRE1;SPC25"]
["Deposition of new CENPA-containing nucleosomes at the centromere Homo sapiens R-HSA-606279","13/52",1.7821091582934786e-09,7.781876657881523e-08,0,0,11.519310754604872,232.0619091115924,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HJURP;CENPA;HIST2H2BE;CENPM;HIST1H2BH;CENPN;HIST1H2AC;HIST1H2BD;HIST1H2BC"]
["Nucleosome assembly Homo sapiens R-HSA-774815","13/52",1.7821091582934786e-09,7.781876657881523e-08,0,0,11.519310754604872,232.0619091115924,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HJURP;CENPA;HIST2H2BE;CENPM;HIST1H2BH;CENPN;HIST1H2AC;HIST1H2BD;HIST1H2BC"]
["G2/M Checkpoints Homo sapiens R-HSA-69481","20/150",1.1681144681933042e-08,4.832305115789143e-07,0,0,5.358511524576507,97.87476621860328,"HIST1H2BO;HIST1H2BK;MCM10;BRCA1;HIST2H2BE;PSMB8;PSMB9;CCNB2;CCNB1;PSMA4;CHEK1;PSME1;CDK1;RBBP8;PSME2;MCM4;HIST1H2BH;ATRIP;HIST1H2BD;HIST1H2BC"]
["DNA methylation Homo sapiens R-HSA-5334118","10/32",1.2803915787468614e-08,5.031938904475166e-07,0,0,15.638297872340425,284.2028377032595,"HIST2H2AA3;HIST1H2BO;UHRF1;HIST1H2BK;HIST1H2AJ;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Condensation of Prophase Chromosomes Homo sapiens R-HSA-2299718","11/41",1.4305307452728693e-08,5.354272218021312e-07,0,0,12.632089994079337,228.16883360399535,"HIST2H2AA3;CCNB1;HIST1H2BO;HIST1H2BK;HIST1H2AJ;CDK1;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Meiotic recombination Homo sapiens R-HSA-912446","12/54",3.180632797847894e-08,1.1363533541402022e-06,0,0,9.854600915099136,170.12589401368598,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;RBBP8;HIST1H2BH;MND1;BRCA1;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Meiotic synapsis Homo sapiens R-HSA-1221632","12/57",6.063651683894408e-08,2.0721870537134798e-06,0,0,9.196204033214709,152.82590776773503,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;BRCA1;HIST1H2AC;HIST2H2BE;HIST1H2BD;REC8;LMNB1;HIST1H2BC"]
["RNA Polymerase I Promoter Opening Homo sapiens R-HSA-73728","9/30",1.0360793320257298e-07,3.393159812384265e-06,0,0,14.719342604298356,236.7260638130957,"HIST2H2AA3;HIST1H2BO;HIST1H2BK;HIST1H2AJ;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Meiosis Homo sapiens R-HSA-1500620","14/85",1.2819587790393363e-07,3.7319244456478454e-06,0,0,6.815140845070423,108.1542846035845,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;MND1;BRCA1;HIST2H2BE;REC8;LMNB1;RBBP8;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST1H2BC"]
["APC/C-mediated degradation of cell cycle proteins Homo sapiens R-HSA-174143","14/85",1.2819587790393363e-07,3.7319244456478454e-06,0,0,6.815140845070423,108.1542846035845,"UBE2C;BUB1B;AURKB;PSMB8;PSMB9;CDC20;CCNA2;CCNB1;PSMA4;PTTG1;PSME1;CDK1;PSME2;NEK2"]
["Regulation of mitotic cell cycle Homo sapiens R-HSA-453276","14/85",1.2819587790393363e-07,3.7319244456478454e-06,0,0,6.815140845070423,108.1542846035845,"UBE2C;BUB1B;AURKB;PSMB8;PSMB9;CDC20;CCNA2;CCNB1;PSMA4;PTTG1;PSME1;CDK1;PSME2;NEK2"]
["Packaging Of Telomere Ends Homo sapiens R-HSA-171306","9/31",1.422980198595787e-07,3.994508700343888e-06,0,0,14.049557522123894,221.49608275800435,"HIST2H2AA3;HIST1H2BO;HIST1H2BK;HIST1H2AJ;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["APC/C:Cdc20 mediated degradation of mitotic proteins Homo sapiens R-HSA-176409","13/74",1.647875995506691e-07,4.319800250306505e-06,0,0,7.356447795213465,114.89747782686042,"UBE2C;BUB1B;PSMB8;PSMB9;CDC20;CCNA2;CCNB1;PSMA4;PTTG1;PSME1;CDK1;PSME2;NEK2"]
["RHO GTPases Activate Formins Homo sapiens R-HSA-5663220","16/114",1.6487787214910322e-07,4.319800250306505e-06,0,0,5.655182503108771,88.32298420201063,"BUB1B;CENPA;NDC80;ZWINT;AURKB;CDC20;CENPE;KIF18A;FMNL1;BIRC5;CENPM;KIF2C;CENPN;SRGAP2;MAPRE1;SPC25"]
["Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Homo sapiens R-HSA-176814","13/75",1.9417826336626142e-07,4.923358548576823e-06,0,0,7.23742165487896,111.85065492034937,"UBE2C;BUB1B;PSMB8;PSMB9;CDC20;CCNA2;CCNB1;PSMA4;PTTG1;PSME1;CDK1;PSME2;NEK2"]
["Senescence-Associated Secretory Phenotype (SASP) Homo sapiens R-HSA-2559582","13/77",2.674247572258479e-07,6.568620599359888e-06,0,0,7.01052807486631,106.10032952777543,"HIST2H2AA3;CDKN1A;HIST1H2BO;UBE2C;HIST1H2AJ;HIST1H2BK;STAT3;HIST2H2BE;CCNA2;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST1H2BC"]
["Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Homo sapiens R-HSA-5625886","9/34",3.428300890112936e-07,8.165589392814448e-06,0,0,12.361699115044248,184.0166347537085,"HIST2H2AA3;HIST1H2BO;HIST1H2BK;HIST1H2AJ;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["SIRT1 negatively regulates rRNA Expression Homo sapiens R-HSA-427359","9/35",4.498327673164582e-07,1.0399075150315771e-05,0,0,11.8856364874064,173.7013264480036,"HIST2H2AA3;HIST1H2BO;HIST1H2BK;HIST1H2AJ;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Chromosome Maintenance Homo sapiens R-HSA-73886","13/86",1.0005366913441264e-06,2.2469195411328094e-05,0,0,6.1433594608453586,84.87035128927509,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HJURP;CENPA;HIST2H2BE;CENPM;HIST1H2BH;CENPN;HIST1H2AC;HIST1H2BD;HIST1H2BC"]
["PRC2 methylates histones and DNA Homo sapiens R-HSA-212300","9/40",1.5328128430098534e-06,3.3466413739048475e-05,0,0,9.966029117898945,133.42924454626691,"HIST2H2AA3;HIST1H2BO;HIST1H2BK;HIST1H2AJ;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["G2/M DNA damage checkpoint Homo sapiens R-HSA-69473","12/78",2.152027843790117e-06,4.5716050951865733e-05,0,0,6.263345195729538,81.73101765069144,"CCNB1;HIST1H2BO;CHEK1;HIST1H2BK;RBBP8;CDK1;HIST1H2BH;BRCA1;ATRIP;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Mitotic Prophase Homo sapiens R-HSA-68875","14/107",2.300773172810246e-06,4.7589676679706675e-05,0,0,5.197043010752688,67.46939129403853,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;VRK2;HIST2H2BE;LMNB1;CCNB2;CCNB1;CDK1;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST1H2BC"]
["Signaling by Rho GTPases Homo sapiens R-HSA-194315","28/367",2.8996972251123487e-06,5.7530878731047196e-05,0,0,2.887376144013312,36.816656692793515,"HIST2H2AA3;HIST1H2BO;HIST1H2BK;KIF14;BUB1B;CENPA;AURKB;CDC20;SRGAP2;HIST1H2AC;LIMK2;HIST1H2AJ;ZWINT;HIST2H2BE;NDC80;CENPE;KIF18A;FMNL1;PRC1;CENPM;BIRC5;KIF2C;CENPN;HIST1H2BH;MAPRE1;HIST1H2BD;SPC25;HIST1H2BC"]
["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Homo sapiens R-HSA-427389","9/43",2.927780088094005e-06,5.7530878731047196e-05,0,0,9.085268089536699,115.75781805707098,"HIST2H2AA3;HIST1H2BO;HIST1H2BK;HIST1H2AJ;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Processing of DNA double-strand break ends Homo sapiens R-HSA-5693607","12/81",3.240898355031677e-06,6.213039285499753e-05,0,0,5.990097477951416,75.71279546732248,"CCNA2;HIST1H2BO;PPP4C;CHEK1;HIST1H2BK;RBBP8;HIST1H2BH;BRCA1;ATRIP;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Amyloid fiber formation Homo sapiens R-HSA-977225","11/68",3.442126649896728e-06,6.249667162944389e-05,0,0,6.639213486647346,83.51746199171312,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;UBE2L6;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;LTF;HIST1H2BC"]
["Diseases associated with the TLR signaling cascade Homo sapiens R-HSA-5602358","7/24",3.498541414370904e-06,6.249667162944389e-05,0,0,14.09513435003631,177.07949029214515,"NFKBIA;LY96;CD14;TICAM1;TLR5;MYD88;TLR2"]
["Diseases of Immune System Homo sapiens R-HSA-5260271","7/24",3.498541414370904e-06,6.249667162944389e-05,0,0,14.09513435003631,177.07949029214515,"NFKBIA;LY96;CD14;TICAM1;TLR5;MYD88;TLR2"]
["Kinesins Homo sapiens R-HSA-983189","9/44",3.587778590829132e-06,6.26665327198155e-05,0,0,8.825233881163085,110.65058228025462,"CENPE;KIF18A;KIF4A;KIF1B;KIF23;KIF2C;KIF11;KIF20A;KIF15"]
["G1/S Transition Homo sapiens R-HSA-69206","14/112",3.98578312947236e-06,6.741409983860475e-05,0,0,4.930612244897959,61.301201260499866,"CDKN1A;RRM2;MCM10;TYMS;PSMB8;CKS1B;PSMB9;CCNA2;CCNB1;PSMA4;PSME1;CDK1;PSME2;MCM4"]
["Cellular Senescence Homo sapiens R-HSA-2559583","17/161",4.03112301833896e-06,6.741409983860475e-05,0,0,4.086799321763415,50.76403701048882,"HIST2H2AA3;CDKN1A;HIST1H2BO;UBE2C;HIST1H2AJ;HIST1H2BK;STAT3;TXN;HIST2H2BE;LMNB1;CCNA2;H1F0;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST1H2BC;HIST1H1C"]
["Ligand-dependent caspase activation Homo sapiens R-HSA-140534","6/17",5.14401605783135e-06,8.423326294698838e-05,0,0,18.6443661971831,227.0450591528935,"TICAM2;TNFSF10;LY96;FAS;CD14;TICAM1"]
["Formation of the beta-catenin:TCF transactivating complex Homo sapiens R-HSA-201722","10/58",5.293939935062392e-06,8.491911814202125e-05,0,0,7.157949172576832,86.9615508532273,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;ASH2L;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Programmed Cell Death Homo sapiens R-HSA-5357801","17/166",6.104281339476629e-06,9.042466278075957e-05,0,0,3.948634222163315,47.4093564483173,"TICAM2;MLKL;HMGB2;LY96;TICAM1;PSMB8;LMNB1;PSMB9;H1F0;CASP7;PSMA4;TNFSF10;PSME1;PSME2;FAS;CD14;HIST1H1C"]
["ISG15 antiviral mechanism Homo sapiens R-HSA-1169408","11/72",6.117849269087692e-06,9.042466278075957e-05,0,0,6.202574032553941,74.45755914777004,"HERC5;DDX58;STAT1;MX2;MX1;TRIM25;EIF2AK2;UBE2L6;ISG15;IFIT1;USP18"]
["Antiviral mechanism by IFN-stimulated genes Homo sapiens R-HSA-1169410","11/72",6.117849269087692e-06,9.042466278075957e-05,0,0,6.202574032553941,74.45755914777004,"HERC5;DDX58;STAT1;MX2;MX1;TRIM25;EIF2AK2;UBE2L6;ISG15;IFIT1;USP18"]
["APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Homo sapiens R-HSA-179419","11/72",6.117849269087692e-06,9.042466278075957e-05,0,0,6.202574032553941,74.45755914777004,"CDC20;CCNA2;PSMA4;UBE2C;PSME1;CDK1;BUB1B;PSME2;NEK2;PSMB8;PSMB9"]
["The role of GTSE1 in G2/M progression after G2 checkpoint Homo sapiens R-HSA-8852276","10/59",6.212381412418597e-06,9.042466278075957e-05,0,0,7.011506730351715,84.06071758877121,"CCNB2;CDKN1A;CCNB1;PSMA4;PSME1;CDK1;PSME2;MAPRE1;PSMB8;PSMB9"]
["HDACs deacetylate histones Homo sapiens R-HSA-3214815","10/60",7.2654916038008615e-06,0.00010383048001068143,0,0,6.8709219858156025,81.29932275477145,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;SAP30;HIST1H2BC"]
["Response to metal ions Homo sapiens R-HSA-5660526","5/11",7.65982188786107e-06,0.00010562491234840001,0,0,28.441710603397773,335.0297508419655,"MT2A;MT1F;MT1X;MT1H;MT1E"]
["Metallothioneins bind metals Homo sapiens R-HSA-5661231","5/11",7.65982188786107e-06,0.00010562491234840001,0,0,28.441710603397773,335.0297508419655,"MT2A;MT1F;MT1X;MT1H;MT1E"]
["Innate Immune System Homo sapiens R-HSA-168249","46/807",8.106784734113279e-06,0.00010986091036229375,0,0,2.13681658901764,25.04949322272274,"C1QB;CDKN1A;UNC93B1;LY96;UBE2L6;CSF2RB;NOD2;TXN;IGLV4-60;IFIH1;HERC5;IFI16;CTSL;CLEC5A;DHX58;C3AR1;TRIM25;CD59;CD14;JAK2;TRIM21;ZBP1;DUSP5;SIGLEC16;TICAM2;DDX58;DEFA4;TREX1;ISG15;TICAM1;PSMB8;PSMB9;RBX1;NFKBIA;PSMA4;AIM2;CFHR3;PSME1;IRF7;PSME2;BPI;TLR7;TLR5;MYD88;TLR2;C1QC"]
["Mitotic G1-G1/S phases Homo sapiens R-HSA-453279","15/136",8.686382778562493e-06,0.00011380746247969194,0,0,4.281183932346723,49.8918641895417,"TOP2A;CDKN1A;RRM2;MCM10;TYMS;PSMB8;CKS1B;PSMB9;CCNA2;CCNB1;PSMA4;PSME1;CDK1;PSME2;MCM4"]
["Activation of anterior HOX genes in hindbrain development during early embryogenesis Homo sapiens R-HSA-5617472","12/89",8.832385764963369e-06,0.00011380746247969194,0,0,5.365531265887138,62.43914551073914,"HIST2H2AA3;EGR2;HIST1H2BO;MAFB;HIST1H2AJ;HIST1H2BK;ASH2L;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Activation of HOX genes during differentiation Homo sapiens R-HSA-5619507","12/89",8.832385764963369e-06,0.00011380746247969194,0,0,5.365531265887138,62.43914551073914,"HIST2H2AA3;EGR2;HIST1H2BO;MAFB;HIST1H2AJ;HIST1H2BK;ASH2L;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Regulation of APC/C activators between G1/S and early anaphase Homo sapiens R-HSA-176408","11/79",1.5261974699827264e-05,0.00019348245345264883,0,0,5.562062480409571,61.684085729873956,"CDC20;CCNA2;CCNB1;PSMA4;UBE2C;PSME1;CDK1;BUB1B;PSME2;PSMB8;PSMB9"]
["Apoptosis Homo sapiens R-HSA-109581","16/163",1.9437642234596993e-05,0.00023879307165651406,0,0,3.760563723697364,40.795719873191246,"TICAM2;HMGB2;LY96;TICAM1;PSMB8;LMNB1;PSMB9;H1F0;CASP7;PSMA4;TNFSF10;PSME1;PSME2;FAS;CD14;HIST1H1C"]
["COPI-dependent Golgi-to-ER retrograde traffic Homo sapiens R-HSA-6811434","11/81",1.9443710669232697e-05,0.00023879307165651406,0,0,5.402588175589952,58.60720575003198,"NAPA;ARF4;CENPE;KIF18A;KIF4A;KIF1B;KIF23;KIF2C;KIF11;KIF20A;KIF15"]
["DNA Repair Homo sapiens R-HSA-73894","22/285",2.7747873618414088e-05,0.00033553582560113035,0,0,2.9039648426737203,30.46941942887512,"INO80C;FANCI;HIST1H2BO;FANCL;HIST1H2BK;ZBTB32;UBE2L6;ISG15;BRCA1;HIST2H2BE;RBX1;CCNA2;PPP4C;KIAA0101;CHEK1;RBBP8;TRIM25;HIST1H2BH;ATRIP;DTL;HIST1H2BD;HIST1H2BC"]
["RNA Polymerase I Chain Elongation Homo sapiens R-HSA-73777","9/57",3.268096134920781e-05,0.00038920053970420215,0,0,6.430752212389381,66.42142530236012,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Cdc20:Phospho-APC/C mediated degradation of Cyclin A Homo sapiens R-HSA-174184","10/71",3.354077780867909e-05,0.00039347837847196666,0,0,5.628705964422742,57.99114255870286,"CDC20;CCNA2;PSMA4;UBE2C;PSME1;CDK1;BUB1B;PSME2;PSMB8;PSMB9"]
["B-WICH complex positively regulates rRNA expression Homo sapiens R-HSA-5250924","9/58",3.771126353476263e-05,0.0004324578629077312,0,0,6.299187285533683,64.16069802073517,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Removal of licensing factors from origins Homo sapiens R-HSA-69300","10/72",3.7963858194190146e-05,0.0004324578629077312,0,0,5.537634408602151,56.366893707003904,"CCNA2;CDKN1A;PSMA4;GMNN;PSME1;MCM4;PSME2;MCM10;PSMB8;PSMB9"]
["NoRC negatively regulates rRNA expression Homo sapiens R-HSA-427413","10/73",4.2875747877174956e-05,0.00048024709172768865,0,0,5.4494540132838,54.80627184149787,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;SAP30;HIST1H2BC"]
["Telomere Maintenance Homo sapiens R-HSA-157579","9/59",4.338109861662327e-05,0.00048024709172768865,0,0,6.172884955752212,62.00963389319852,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["RHO GTPases activate PKNs Homo sapiens R-HSA-5625740","9/60",4.975448091559169e-05,0.0005431530833285425,0,0,6.051535658511192,59.96109661424561,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Toll-Like Receptors Cascades Homo sapiens R-HSA-168898","14/140",5.1845321113376424e-05,0.0005582249643166282,0,0,3.8293650793650795,37.78528674974223,"TICAM2;UNC93B1;LY96;NOD2;TICAM1;NFKBIA;CTSL;IRF7;TLR7;BPI;CD14;TLR5;MYD88;TLR2"]
["Regulation of DNA replication Homo sapiens R-HSA-69304","10/75",5.434223210324846e-05,0.0005772026274750444,0,0,5.281232951445717,51.86281071760263,"CCNA2;CDKN1A;PSMA4;GMNN;PSME1;MCM4;PSME2;MCM10;PSMB8;PSMB9"]
["Negative epigenetic regulation of rRNA expression Homo sapiens R-HSA-5250941","10/76",6.0992188022029175e-05,0.0006391981304708657,0,0,5.200945626477542,50.47395387198636,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;SAP30;HIST1H2BC"]
["TCF dependent signaling in response to WNT Homo sapiens R-HSA-201681","17/199",6.436514027734109e-05,0.0006656710560261855,0,0,3.2271391086471874,31.14492065365335,"HIST2H2AA3;HIST1H2BO;CAV1;HIST1H2AJ;HIST1H2BK;ASH2L;HIST2H2BE;PSMB8;PSMB9;RBX1;PSMA4;PSME1;PSME2;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST1H2BC"]
["RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Homo sapiens R-HSA-168928","10/79",8.524547766806983e-05,0.000870168122689648,0,0,4.974046664610957,46.60669533894072,"HERC5;IFIH1;NFKBIA;DDX58;DHX58;IRF7;TRIM25;UBE2L6;ISG15;MYD88"]
["HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) Homo sapiens R-HSA-5693567","12/112",9.04410430767406e-05,0.0009113674340810015,0,0,4.126548042704626,38.42151459139186,"CCNA2;PPP4C;HIST1H2BO;CHEK1;HIST1H2BK;RBBP8;HIST1H2BH;BRCA1;ATRIP;HIST1H2BD;HIST2H2BE;HIST1H2BC"]
["Caspase activation via extrinsic apoptotic signalig pathway Homo sapiens R-HSA-5357769","6/27",9.634152744642713e-05,0.0009585372224416674,0,0,9.761066398390343,90.26654599447863,"TICAM2;TNFSF10;LY96;FAS;CD14;TICAM1"]
["Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Homo sapiens R-HSA-936964","5/18",0.00012021235629291148,0.001181086400577855,0,0,13.122211707448965,118.44437317900045,"TICAM2;IRF7;LY96;CD14;TICAM1"]
["TRIF-mediated programmed cell death Homo sapiens R-HSA-2562578","4/10",0.0001228405996260228,0.0011920087815562215,0,0,22.71345029239766,204.52605648175896,"TICAM2;LY96;CD14;TICAM1"]
["G2/M Transition Homo sapiens R-HSA-69275","15/173",0.00014494747806147797,0.0013893746067844108,0,0,3.2723443762595954,28.924707129530855,"CDKN1A;FOXM1;PSMB8;PSMB9;CCNA2;CCNB2;TPX2;CCNB1;PSMA4;PSME1;CDK1;PSME2;NEK2;MAPRE1;RAB8A"]
["Homology Directed Repair Homo sapiens R-HSA-5693538","12/118",0.00014955268739682878,0.0014162459312518966,0,0,3.8917612301081044,34.27809508569301,"CCNA2;PPP4C;HIST1H2BO;CHEK1;HIST1H2BK;RBBP8;HIST1H2BH;BRCA1;ATRIP;HIST1H2BD;HIST2H2BE;HIST1H2BC"]
["Mitotic G2-G2/M phases Homo sapiens R-HSA-453274","15/175",0.00016463906418159781,0.0015405512434135224,0,0,3.2311046511627906,28.148592003108387,"CDKN1A;FOXM1;PSMB8;PSMB9;CCNA2;CCNB2;TPX2;CCNB1;PSMA4;PSME1;CDK1;PSME2;NEK2;MAPRE1;RAB8A"]
["MHC class II antigen presentation Homo sapiens R-HSA-2132295","11/103",0.00018135105595959292,0.0016740528483585142,0,0,4.105992740752182,35.37343898111794,"CENPE;KIF18A;CTSL;KIF4A;KIF23;KIF2C;KIF20A;KIF11;IFI30;CTSD;KIF15"]
["MyD88 deficiency (TLR2/4) Homo sapiens R-HSA-5602498","4/11",0.00018865872212846477,0.0016740528483585142,0,0,19.467669172932332,166.94637682535404,"LY96;CD14;MYD88;TLR2"]
["IRAK4 deficiency (TLR2/4) Homo sapiens R-HSA-5603041","4/11",0.00018865872212846477,0.0016740528483585142,0,0,19.467669172932332,166.94637682535404,"LY96;CD14;MYD88;TLR2"]
["Condensation of Prometaphase Chromosomes Homo sapiens R-HSA-2514853","4/11",0.00018865872212846477,0.0016740528483585142,0,0,19.467669172932332,166.94637682535404,"CCNB2;CCNB1;CDK1;NCAPG"]
["APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Homo sapiens R-HSA-174178","9/71",0.00018955560242227447,0.0016740528483585142,0,0,4.975049957179561,42.640298270419315,"CDC20;PSMA4;PTTG1;UBE2C;PSME1;PSME2;AURKB;PSMB8;PSMB9"]
["Transcriptional regulation by small RNAs Homo sapiens R-HSA-5578749","9/72",0.0002112116704408799,0.0018445819218503507,0,0,4.89582806573957,41.43167815603299,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["DNA Replication Homo sapiens R-HSA-69306","11/105",0.00021517156660536352,0.0018585148500199528,0,0,4.018215486943048,33.930112390811466,"CCNA2;GINS2;CDKN1A;PSMA4;GMNN;PSME1;PSME2;MCM4;MCM10;PSMB8;PSMB9"]
["G2/M DNA replication checkpoint Homo sapiens R-HSA-69478","3/5",0.0002252333727608832,0.0019242764238049368,0,0,51.02626970227671,428.53767030308984,"CCNB2;CCNB1;CDK1"]
["Positive epigenetic regulation of rRNA expression Homo sapiens R-HSA-5250913","9/73",0.00023488402148414412,0.00198514882673696,0,0,4.819081858407079,40.270265716224635,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["SCF(Skp2)-mediated degradation of p27/p21 Homo sapiens R-HSA-187577","8/59",0.0002679266880826795,0.0022403231577977248,0,0,5.369639021686413,44.16419181233666,"CCNA2;CDKN1A;PSMA4;PSME1;PSME2;PSMB8;CKS1B;PSMB9"]
["Oxidative Stress Induced Senescence Homo sapiens R-HSA-2559580","10/91",0.0002797858429627841,0.0023148597112499824,0,0,4.234524122230978,34.64470022074398,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;TXN;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["DNA Damage Bypass Homo sapiens R-HSA-73893","7/46",0.00031315038806002383,0.002563918802241445,0,0,6.137068692624248,49.5189456279163,"KIAA0101;ZBTB32;TRIM25;UBE2L6;ISG15;DTL;RBX1"]
["RNA Polymerase I Promoter Clearance Homo sapiens R-HSA-73854","9/76",0.00031946712344598746,0.0025886717425623314,0,0,4.6025888257825915,37.04557555791117,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Golgi-to-ER retrograde transport Homo sapiens R-HSA-8856688","11/110",0.00032379179259190045,0.002596942336502385,0,0,3.814288533649102,30.64937170816932,"NAPA;ARF4;CENPE;KIF18A;KIF4A;KIF1B;KIF23;KIF2C;KIF20A;KIF11;KIF15"]
["Cyclin A/B1 associated events during G2/M transition Homo sapiens R-HSA-69273","5/22",0.0003359781860765718,0.0026674631743049035,0,0,10.032564871291223,80.24511218618738,"CCNA2;CCNB2;CCNB1;CDK1;FOXM1"]
["Negative regulators of RIG-I/MDA5 signaling Homo sapiens R-HSA-936440","6/34",0.000369133124364326,0.0029013863575036033,0,0,7.318158953722334,57.84531320507623,"IFIH1;HERC5;DDX58;TRIM25;UBE2L6;ISG15"]
["RNA Polymerase I Transcription Homo sapiens R-HSA-73864","9/79",0.00042777105714167585,0.003328990603102546,0,0,4.404652338811631,34.16654647359532,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Phosphorylation of Emi1 Homo sapiens R-HSA-176417","3/6",0.0004408493194605601,0.003397132991137257,0,0,34.01576182136603,262.833240842734,"CDC20;CCNB1;CDK1"]
["Epigenetic regulation of gene expression Homo sapiens R-HSA-212165","11/115",0.0004752650597276942,0.0036267799703492,0,0,3.6299699412488047,27.77521553870194,"HIST2H2AA3;HIST1H2BO;UHRF1;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST2H2BE;SAP30;HIST1H2BC"]
["TRAF6 mediated NF-kB activation Homo sapiens R-HSA-933542","5/24",0.0005171668267184905,0.0039085877480839765,0,0,8.975580427342521,67.919519030954,"IFIH1;NFKBIA;DDX58;TRIM25;MYD88"]
["G1/S DNA Damage Checkpoints Homo sapiens R-HSA-69615","8/65",0.0005247521557938821,0.003928144709085632,0,0,4.802926043022751,36.274504744153475,"CCNA2;CDKN1A;PSMA4;CHEK1;PSME1;PSME2;PSMB8;PSMB9"]
["TRAF3-dependent IRF activation pathway Homo sapiens R-HSA-918233","4/14",0.0005342880371742092,0.003961796200178569,0,0,13.625263157894738,102.66057354770984,"IFIH1;DDX58;IRF7;TRIM25"]
["Class I MHC mediated antigen processing & presentation Homo sapiens R-HSA-983169","20/305",0.0005528689562425379,0.00406126167856668,0,0,2.424599404648806,18.185440045670752,"DTX3L;UBE2C;TAP1;UBE2L6;PSMB8;UBE2J1;PSMB9;RBX1;CDC20;HERC5;PSMA4;CTSL;SEC61G;PSME1;PSME2;TRIM69;FBXO6;TRIM21;FCGR1B;HERC6"]
["Antigen processing-Cross presentation Homo sapiens R-HSA-1236975","9/82",0.0005646072999142774,0.004109086460487241,0,0,4.222984604194448,31.585307065579464,"PSMA4;CTSL;SEC61G;PSME1;TAP1;PSME2;FCGR1B;PSMB8;PSMB9"]
["APC/C:Cdc20 mediated degradation of Securin Homo sapiens R-HSA-174154","8/66",0.0005823795242933696,0.004161366419041714,0,0,4.719873278908249,35.15544852656312,"CDC20;PSMA4;PTTG1;UBE2C;PSME1;PSME2;PSMB8;PSMB9"]
["Cytosolic sensors of pathogen-associated DNA Homo sapiens R-HSA-1834949","8/66",0.0005823795242933696,0.004161366419041714,0,0,4.719873278908249,35.15544852656312,"ZBP1;NFKBIA;IFI16;TREX1;IRF7;TICAM1;TRIM21;MYD88"]
["Gene Silencing by RNA Homo sapiens R-HSA-211000","10/101",0.0006481298929771752,0.004589460323243782,0,0,3.7672433949029696,27.656913855277132,"HIST2H2AA3;PIWIL4;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST2H2BE;HIST1H2BC"]
["Nonhomologous End-Joining (NHEJ) Homo sapiens R-HSA-5693571","7/52",0.0006748833460590854,0.004736234910736083,0,0,5.317146776406036,38.820332836390726,"HIST1H2BO;HIST1H2BK;HIST1H2BH;BRCA1;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Cyclin E associated events during G1/S transition Homo sapiens R-HSA-69202","8/68",0.0007129692241204351,0.004953864478432002,0,0,4.562073027090695,33.05711100316462,"CCNA2;CDKN1A;PSMA4;PSME1;PSME2;PSMB8;CKS1B;PSMB9"]
["Adaptive Immune System Homo sapiens R-HSA-1280218","38/762",0.0007184994281695271,0.004953864478432002,0,0,1.8313370990352107,13.255850921394861,"CDKN1A;IFITM1;UBE2L6;KIF11;IFI30;LILRA3;UBE2J1;KIF15;IGLV4-60;HERC5;CDC20;CTSL;SEC61G;TRIM69;FBXO6;FCGR1B;TRIM21;CTSD;HERC6;DTX3L;UBE2C;TAP1;KIF23;PSMB8;PSMB9;RBX1;OSCAR;NFKBIA;CENPE;KIF18A;PSMA4;SELL;KIF4A;PSME1;PSME2;KIF2C;SIGLEC1;KIF20A"]
["Activation of NIMA Kinases NEK9 NEK6 NEK7 Homo sapiens R-HSA-2980767","3/7",0.0007550378553386837,0.005160519602575699,0,0,25.510507880910684,183.38847654837295,"CCNB2;CCNB1;CDK1"]
["Cyclin A:Cdk2-associated events at S phase entry Homo sapiens R-HSA-69656","8/69",0.0007865718318293759,0.0053297022398093915,0,0,4.487053235243005,32.072678060544625,"CCNA2;CDKN1A;PSMA4;PSME1;PSME2;PSMB8;CKS1B;PSMB9"]
["Switching of origins to a post-replicative state Homo sapiens R-HSA-69052","8/70",0.0008661583060649774,0.00576949515734807,0,0,4.414453436680725,31.12826618739995,"CCNA2;CDKN1A;PSMA4;PSME1;MCM4;PSME2;PSMB8;PSMB9"]
["Orc1 removal from chromatin Homo sapiens R-HSA-68949","8/70",0.0008661583060649774,0.00576949515734807,0,0,4.414453436680725,31.12826618739995,"CCNA2;CDKN1A;PSMA4;PSME1;MCM4;PSME2;PSMB8;PSMB9"]
["S Phase Homo sapiens R-HSA-69242","11/124",0.0008968470047969652,0.005923712149331214,0,0,3.339301152171521,23.430624860712438,"CCNA2;GINS2;CDKN1A;PSMA4;CDCA5;PSME1;PSME2;MCM4;PSMB8;CKS1B;PSMB9"]
["STING mediated induction of host immune responses Homo sapiens R-HSA-1834941","4/16",0.000928069444334054,0.006028616390467491,0,0,11.353216374269007,79.27274337598489,"ZBP1;IFI16;TREX1;TRIM21"]
["TRAF6 mediated induction of TAK1 complex Homo sapiens R-HSA-937072","4/16",0.000928069444334054,0.006028616390467491,0,0,11.353216374269007,79.27274337598489,"TICAM2;LY96;CD14;TICAM1"]
["DNA Double-Strand Break Repair Homo sapiens R-HSA-5693532","12/145",0.000986253038714599,0.006354056462538318,0,0,3.097369758916865,21.438747104280548,"CCNA2;PPP4C;HIST1H2BO;CHEK1;HIST1H2BK;RBBP8;HIST1H2BH;BRCA1;ATRIP;HIST1H2BD;HIST2H2BE;HIST1H2BC"]
["Formation of Senescence-Associated Heterochromatin Foci (SAHF) Homo sapiens R-HSA-2559584","4/17",0.0011862732785636971,0.007580575584968017,0,0,10.479352226720648,70.59875235754825,"CDKN1A;H1F0;LMNB1;HIST1H1C"]
["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Homo sapiens R-HSA-5693565","7/58",0.001308340664227177,0.008293191629698073,0,0,4.690147664003873,31.1378697665848,"HIST1H2BO;HIST1H2BK;HIST1H2BH;BRCA1;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["DNA Double Strand Break Response Homo sapiens R-HSA-5693606","7/59",0.00144839689066623,0.009107519648509256,0,0,4.5997150997151,30.069707985293476,"HIST1H2BO;HIST1H2BK;HIST1H2BH;BRCA1;HIST2H2BE;HIST1H2BD;HIST1H2BC"]
["Pyrimidine salvage reactions Homo sapiens R-HSA-73614","3/9",0.0017358059580014722,0.010828122880866329,0,0,17.00525394045534,108.0902140884472,"TK1;UPP1;TYMP"]
["Synthesis of DNA Homo sapiens R-HSA-69239","9/97",0.0018865141516214773,0.011675591521058909,0,0,3.5004424778761063,21.958361484295818,"CCNA2;GINS2;CDKN1A;PSMA4;PSME1;PSME2;MCM4;PSMB8;PSMB9"]
["TRAF6 mediated IRF7 activation Homo sapiens R-HSA-933541","5/32",0.0020283311960801274,0.012455221250929533,0,0,6.313545531471718,39.14740357331542,"IFIH1;DDX58;IRF7;TRIM25;MYD88"]
["p53-Dependent G1/S DNA damage checkpoint Homo sapiens R-HSA-69580","7/63",0.0021291411553002564,0.012873114985123085,0,0,4.270282186948854,26.270932281017565,"CCNA2;CDKN1A;PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["p53-Dependent G1 DNA Damage Response Homo sapiens R-HSA-69563","7/63",0.0021291411553002564,0.012873114985123085,0,0,4.270282186948854,26.270932281017565,"CCNA2;CDKN1A;PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Signaling by Wnt Homo sapiens R-HSA-195721","18/295",0.0022818378536587297,0.013691027121952378,0,0,2.238020413993715,13.613372574945107,"HIST2H2AA3;HIST1H2BO;CAV1;HIST1H2AJ;HIST1H2BK;ASH2L;HIST2H2BE;PSMB8;PSMB9;RBX1;PSMA4;GNG5;PSME1;PSME2;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST1H2BC"]
["DNA Replication Pre-Initiation Homo sapiens R-HSA-69002","8/82",0.002425097307711543,0.014331778074144909,0,0,3.6963040779295198,22.258713012865197,"PSMA4;GMNN;PSME1;MCM4;PSME2;MCM10;PSMB8;PSMB9"]
["M/G1 Transition Homo sapiens R-HSA-68874","8/82",0.002425097307711543,0.014331778074144909,0,0,3.6963040779295198,22.258713012865197,"PSMA4;GMNN;PSME1;MCM4;PSME2;MCM10;PSMB8;PSMB9"]
["Factors involved in megakaryocyte development and platelet production Homo sapiens R-HSA-983231","11/141",0.002525601767208869,0.014814350664374415,0,0,2.900068315343626,17.34610878382655,"CENPE;KIF18A;KIF4A;IRF7;KIF1B;KIF23;KIF2C;KIF20A;KIF11;JAK2;KIF15"]
["ER-Phagosome pathway Homo sapiens R-HSA-1236974","7/65",0.002550869274051575,0.014851727773366949,0,0,4.1226053639846745,24.617400339701867,"PSMA4;SEC61G;PSME1;TAP1;PSME2;PSMB8;PSMB9"]
["Cross-presentation of soluble exogenous antigens (endosomes) Homo sapiens R-HSA-1236978","6/49",0.002669945717489313,0.015425700247728866,0,0,4.761627906976744,28.215964857283662,"PSMA4;PSME1;PSME2;FCGR1B;PSMB8;PSMB9"]
["Transcriptional Regulation by TP53 Homo sapiens R-HSA-3700989","20/348",0.002695429623231087,0.015425700247728866,0,0,2.1020075724222944,12.435892307328462,"COX8A;FANCI;CDKN1A;GADD45A;SUPT4H1;TXN;BRCA1;COX5B;AURKB;PML;CCNA2;TPX2;CCNB1;SCO2;CHEK1;CDK1;RBBP8;FAS;BIRC5;ATRIP"]
["RIP-mediated NFkB activation via ZBP1 Homo sapiens R-HSA-1810476","4/21",0.0027237499539438824,0.015425700247728866,0,0,8.011971104231167,47.3166638061174,"ZBP1;NFKBIA;TICAM1;MYD88"]
["Toll Like Receptor 4 (TLR4) Cascade Homo sapiens R-HSA-166016","10/122",0.002727954623962229,0.015425700247728866,0,0,3.0575607902735564,18.052460118302154,"NFKBIA;TICAM2;IRF7;LY96;BPI;CD14;NOD2;TICAM1;MYD88;TLR2"]
["Assembly of the pre-replicative complex Homo sapiens R-HSA-68867","7/67",0.00303401767975221,0.017033842116323125,0,0,3.9847736625514405,23.10318999533893,"PSMA4;GMNN;PSME1;MCM4;PSME2;PSMB8;PSMB9"]
["Interleukin-6 signaling Homo sapiens R-HSA-1059683","3/11",0.0032664923746153064,0.01808072539751853,0,0,12.75262697022767,72.99652823968249,"STAT1;STAT3;JAK2"]
["TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Homo sapiens R-HSA-975110","3/11",0.0032664923746153064,0.01808072539751853,0,0,12.75262697022767,72.99652823968249,"IRF7;TLR7;MYD88"]
["Antigen processing: Ubiquitination & Proteasome degradation Homo sapiens R-HSA-983168","16/260",0.0035914125851511224,0.01946878770401263,0,0,2.2541864974440333,12.689288443182097,"DTX3L;UBE2C;UBE2L6;PSMB8;UBE2J1;PSMB9;RBX1;CDC20;HERC5;PSMA4;PSME1;PSME2;TRIM69;FBXO6;TRIM21;HERC6"]
["p53-Independent DNA Damage Response Homo sapiens R-HSA-69610","6/52",0.0036163397007453486,0.01946878770401263,0,0,4.450398040416411,25.021441291787255,"PSMA4;CHEK1;PSME1;PSME2;PSMB8;PSMB9"]
["p53-Independent G1/S DNA damage checkpoint Homo sapiens R-HSA-69613","6/52",0.0036163397007453486,0.01946878770401263,0,0,4.450398040416411,25.021441291787255,"PSMA4;CHEK1;PSME1;PSME2;PSMB8;PSMB9"]
["Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Homo sapiens R-HSA-69601","6/52",0.0036163397007453486,0.01946878770401263,0,0,4.450398040416411,25.021441291787255,"PSMA4;CHEK1;PSME1;PSME2;PSMB8;PSMB9"]
["HATs acetylate histones Homo sapiens R-HSA-3214847","9/107",0.0036822758470858854,0.0196889035089082,0,0,3.14162904099693,17.60639375422368,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST2H2BE;HIST1H2BC"]
["APC/C:Cdc20 mediated degradation of Cyclin B Homo sapiens R-HSA-174048","4/23",0.0038512384865859216,0.020453198989571177,0,0,7.1678670360110806,39.8487568519374,"CDC20;CCNB1;UBE2C;CDK1"]
["Vif-mediated degradation of APOBEC3G Homo sapiens R-HSA-180585","6/53",0.003981153741105027,0.02100125396314463,0,0,4.3554839676356005,24.069204146030003,"PSMA4;PSME1;PSME2;PSMB8;RBX1;PSMB9"]
["Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Homo sapiens R-HSA-75035","3/12",0.004263134641739924,0.022190886280844906,0,0,11.335084646818448,61.864064554991025,"CCNB1;CHEK1;CDK1"]
["NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Homo sapiens R-HSA-933543","3/12",0.004263134641739924,0.022190886280844906,0,0,11.335084646818448,61.864064554991025,"IFIH1;DDX58;TRIM25"]
["SCF-beta-TrCP mediated degradation of Emi1 Homo sapiens R-HSA-174113","6/54",0.004372499049027063,0.022610422714047843,0,0,4.264524647887324,23.166691412318723,"CDC20;PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Growth hormone receptor signaling Homo sapiens R-HSA-982772","4/24",0.004518055121186061,0.02291091177582093,0,0,6.809122807017544,36.76704107324984,"CISH;STAT1;STAT3;JAK2"]
["IKK complex recruitment mediated by RIP1 Homo sapiens R-HSA-937041","4/24",0.004518055121186061,0.02291091177582093,0,0,6.809122807017544,36.76704107324984,"TICAM2;LY96;CD14;TICAM1"]
["Pyrimidine metabolism Homo sapiens R-HSA-73848","4/24",0.004518055121186061,0.02291091177582093,0,0,6.809122807017544,36.76704107324984,"TK1;UPP1;TYMS;TYMP"]
["Activated TLR4 signalling Homo sapiens R-HSA-166054","9/112",0.004979067178779866,0.025086838477698558,0,0,2.9883495145631067,15.845761309755353,"NFKBIA;TICAM2;IRF7;LY96;CD14;NOD2;TICAM1;MYD88;TLR2"]
["Degradation of DVL Homo sapiens R-HSA-4641258","6/56",0.005239267768989809,0.025994287874667683,0,0,4.093521126760564,21.497427190336442,"PSMA4;PSME1;PSME2;PSMB8;RBX1;PSMB9"]
["Chemokine receptors bind chemokines Homo sapiens R-HSA-380108","6/56",0.005239267768989809,0.025994287874667683,0,0,4.093521126760564,21.497427190336442,"CCR1;CXCL10;CCRL2;CCL3;CCL2;CXCL13"]
["APC-Cdc20 mediated degradation of Nek2A Homo sapiens R-HSA-179409","4/25",0.005258386478463309,0.025994287874667683,0,0,6.484544695071011,34.03044346616416,"CDC20;UBE2C;BUB1B;NEK2"]
["IRF3-mediated induction of type I IFN Homo sapiens R-HSA-3270619","3/13",0.005424941079460909,0.026159531831020093,0,0,10.201050788091068,53.216313750468544,"ZBP1;IFI16;TREX1"]
["Activation of DNA fragmentation factor Homo sapiens R-HSA-211227","3/13",0.005424941079460909,0.026159531831020093,0,0,10.201050788091068,53.216313750468544,"H1F0;HMGB2;HIST1H1C"]
["Apoptosis induced DNA fragmentation Homo sapiens R-HSA-140342","3/13",0.005424941079460909,0.026159531831020093,0,0,10.201050788091068,53.216313750468544,"H1F0;HMGB2;HIST1H1C"]
["Trafficking and processing of endosomal TLR Homo sapiens R-HSA-1679131","3/13",0.005424941079460909,0.026159531831020093,0,0,10.201050788091068,53.216313750468544,"UNC93B1;CTSL;TLR7"]
["ZBP1(DAI) mediated induction of type I IFNs Homo sapiens R-HSA-1606322","4/26",0.006075665939508896,0.029118740417402398,0,0,6.189473684210526,31.58775412149003,"ZBP1;NFKBIA;TICAM1;MYD88"]
["CDT1 association with the CDC6:ORC:origin complex Homo sapiens R-HSA-68827","6/58",0.0062256213164690885,0.02959888963869044,0,0,3.9356717226435536,19.9895995292962,"PSMA4;GMNN;PSME1;PSME2;PSMB8;PSMB9"]
["RNA Polymerase I"," RNA Polymerase III"," and Mitochondrial Transcription Homo sapiens R-HSA-504046","9/116",0.006251164987306123,0.02959888963869044,0,0,2.876040029774212,14.595867012610796,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST2H2BE;HIST1H2BC"]
["Regulation of IFNG signaling Homo sapiens R-HSA-877312","3/14",0.00675876031409357,0.0306329653998617,0,0,9.273204903677758,46.33742401853184,"STAT1;IFNGR2;JAK2"]
["Golgi Cisternae Pericentriolar Stack Reorganization Homo sapiens R-HSA-162658","3/14",0.00675876031409357,0.0306329653998617,0,0,9.273204903677758,46.33742401853184,"CCNB2;CCNB1;CDK1"]
["Degradation of GLI1 by the proteasome Homo sapiens R-HSA-5610780","6/59",0.006766440483623085,0.0306329653998617,0,0,3.8612144565506243,19.289778375633063,"PSMA4;PSME1;PSME2;PSMB8;RBX1;PSMB9"]
["GLI3 is processed to GLI3R by the proteasome Homo sapiens R-HSA-5610785","6/59",0.006766440483623085,0.0306329653998617,0,0,3.8612144565506243,19.289778375633063,"PSMA4;PSME1;PSME2;PSMB8;RBX1;PSMB9"]
["Degradation of GLI2 by the proteasome Homo sapiens R-HSA-5610783","6/59",0.006766440483623085,0.0306329653998617,0,0,3.8612144565506243,19.289778375633063,"PSMA4;PSME1;PSME2;PSMB8;RBX1;PSMB9"]
["MyD88-independent TLR3/TLR4 cascade Homo sapiens R-HSA-166166","8/97",0.0067813434854655675,0.0306329653998617,0,0,3.0709492992416725,15.335031132103799,"NFKBIA;TICAM2;IRF7;LY96;CD14;NOD2;TICAM1;MYD88"]
["Toll Like Receptor 3 (TLR3) Cascade Homo sapiens R-HSA-168164","8/97",0.0067813434854655675,0.0306329653998617,0,0,3.0709492992416725,15.335031132103799,"NFKBIA;TICAM2;IRF7;LY96;CD14;NOD2;TICAM1;MYD88"]
["TRIF-mediated TLR3/TLR4 signaling Homo sapiens R-HSA-937061","8/97",0.0067813434854655675,0.0306329653998617,0,0,3.0709492992416725,15.335031132103799,"NFKBIA;TICAM2;IRF7;LY96;CD14;NOD2;TICAM1;MYD88"]
["Cyclin B2 mediated events Homo sapiens R-HSA-157881","2/5",0.0077624645038729114,0.0348645548573949,0,0,22.63752913752914,109.98342578282237,"CCNB2;CDK1"]
["Depolymerisation of the Nuclear Lamina Homo sapiens R-HSA-4419969","3/15",0.008270425485228095,0.03672629622253832,0,0,8.5,40.75808923724137,"CCNB1;CDK1;LMNB1"]
["Regulation of innate immune responses to cytosolic DNA Homo sapiens R-HSA-3134975","3/15",0.008270425485228095,0.03672629622253832,0,0,8.5,40.75808923724137,"ZBP1;TREX1;TRIM21"]
["Autodegradation of Cdh1 by Cdh1:APC/C Homo sapiens R-HSA-174084","6/62",0.008592773907432065,0.037943372422705644,0,0,3.6537977867203217,17.380508343452103,"PSMA4;UBE2C;PSME1;PSME2;PSMB8;PSMB9"]
["Regulated Necrosis Homo sapiens R-HSA-5218859","3/16",0.009964820538990971,0.043272646097496696,0,0,7.845749696888051,36.158662178835016,"MLKL;TNFSF10;FAS"]
["RIPK1-mediated regulated necrosis Homo sapiens R-HSA-5213460","3/16",0.009964820538990971,0.043272646097496696,0,0,7.845749696888051,36.158662178835016,"MLKL;TNFSF10;FAS"]
["Polo-like kinase mediated events Homo sapiens R-HSA-156711","3/16",0.009964820538990971,0.043272646097496696,0,0,7.845749696888051,36.158662178835016,"CCNB2;CCNB1;FOXM1"]
["Cellular responses to stress Homo sapiens R-HSA-2262752","19/367",0.010066752470982926,0.043475095836222964,0,0,1.8767836802319562,8.630421883516792,"HIST2H2AA3;CDKN1A;HIST1H2BO;UBE2C;STAT3;HIST1H2AJ;HIST1H2BK;TXN;HIST2H2BE;ATOX1;RBX1;LMNB1;CCNA2;H1F0;HIST1H2BH;HIST1H2AC;HIST1H2BD;HIST1H2BC;HIST1H1C"]
["Termination of translesion DNA synthesis Homo sapiens R-HSA-5656169","4/30",0.010177732266943781,0.04371419432687329,0,0,5.236167341430499,24.02119549014661,"KIAA0101;TRIM25;UBE2L6;ISG15"]
["Fibronectin matrix formation Homo sapiens R-HSA-1566977","2/6",0.011423286472911257,0.0485335306362608,0,0,16.977272727272727,75.92408401028655,"CEACAM1;CEACAM8"]
["Protein repair Homo sapiens R-HSA-5676934","2/6",0.011423286472911257,0.0485335306362608,0,0,16.977272727272727,75.92408401028655,"TXN;MSRB1"]
["Activation of NF-kappaB in B cells Homo sapiens R-HSA-1169091","6/66",0.011544117511175057,0.04878320625690105,0,0,3.409507042253521,15.211785968413412,"NFKBIA;PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["G1/S-Specific Transcription Homo sapiens R-HSA-69205","3/17",0.011845943174741047,0.049586951387336285,0,0,7.284963722792094,32.31442220779588,"RRM2;CDK1;TYMS"]
["TP53 Regulates Transcription of Cell Cycle Genes Homo sapiens R-HSA-6791312","5/48",0.011860492189337431,0.049586951387336285,0,0,3.96104957698124,17.565442243475935,"CCNA2;CDKN1A;CCNB1;GADD45A;CDK1"]
["Regulation of RAS by GAPs Homo sapiens R-HSA-5658442","6/67",0.0123811781153006,0.05148997882871043,0,0,3.353440314015239,14.726894215951326,"PSMA4;PSME1;PSME2;PSMB8;RBX1;PSMB9"]
["Metabolism of nucleotides Homo sapiens R-HSA-15869","7/87",0.012522545431177414,0.051803793204765525,0,0,2.985493827160494,13.077133578842826,"RRM2;GLRX;TK1;UPP1;TXN;TYMS;TYMP"]
["Regulation of activated PAK-2p34 by proteasome mediated degradation Homo sapiens R-HSA-211733","5/49",0.012904874628843861,0.053105923865294634,0,0,3.8708260105448153,16.83867439215215,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Homo sapiens R-HSA-6804114","3/18",0.013916964599501865,0.0558451384207458,0,0,6.798949211908932,29.063105868144135,"CCNB1;GADD45A;CDK1"]
["CDK-mediated phosphorylation and removal of Cdc6 Homo sapiens R-HSA-69017","5/50",0.0140096580951451,0.0558451384207458,0,0,3.7846123803944542,16.15275713989196,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Ubiquitin-dependent degradation of Cyclin D1 Homo sapiens R-HSA-69229","5/50",0.0140096580951451,0.0558451384207458,0,0,3.7846123803944542,16.15275713989196,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Ubiquitin-dependent degradation of Cyclin D Homo sapiens R-HSA-75815","5/50",0.0140096580951451,0.0558451384207458,0,0,3.7846123803944542,16.15275713989196,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Regulation of Apoptosis Homo sapiens R-HSA-169911","5/50",0.0140096580951451,0.0558451384207458,0,0,3.7846123803944542,16.15275713989196,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Regulation of ornithine decarboxylase (ODC) Homo sapiens R-HSA-350562","5/50",0.0140096580951451,0.0558451384207458,0,0,3.7846123803944542,16.15275713989196,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Regulation of TP53 Activity through Phosphorylation Homo sapiens R-HSA-6804756","7/89",0.014067859296829096,0.0558451384207458,0,0,2.912375790424571,12.417970111112524,"CCNA2;TPX2;CHEK1;RBBP8;BRCA1;ATRIP;AURKB"]
["E2F mediated regulation of DNA replication Homo sapiens R-HSA-113510","4/33",0.014207599982356982,0.05611645018157079,0,0,4.693768905021174,19.96719082086267,"CCNB1;RRM2;CDK1;TYMS"]
["Intra-Golgi and retrograde Golgi-to-ER traffic Homo sapiens R-HSA-6811442","11/179",0.014503012722484976,0.05699683999936595,0,0,2.2396811300008457,9.481463580971468,"NAPA;ARF4;CENPE;KIF18A;KIF4A;KIF1B;KIF23;KIF2C;KIF20A;KIF11;KIF15"]
["Nuclear Envelope Breakdown Homo sapiens R-HSA-2980766","5/51",0.015176260136364089,0.058473237584226345,0,0,3.7021471689462824,15.504677141955943,"CCNB2;CCNB1;CDK1;VRK2;LMNB1"]
["Vpu mediated degradation of CD4 Homo sapiens R-HSA-180534","5/51",0.015176260136364089,0.058473237584226345,0,0,3.7021471689462824,15.504677141955943,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Autodegradation of the E3 ubiquitin ligase COP1 Homo sapiens R-HSA-349425","5/51",0.015176260136364089,0.058473237584226345,0,0,3.7021471689462824,15.504677141955943,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Apoptotic execution  phase Homo sapiens R-HSA-75153","5/51",0.015176260136364089,0.058473237584226345,0,0,3.7021471689462824,15.504677141955943,"CASP7;H1F0;HMGB2;LMNB1;HIST1H1C"]
["Vesicle-mediated transport Homo sapiens R-HSA-5653656","23/492",0.0155863306237778,0.05976027253799683,0,0,1.6872250105448903,7.021152341780452,"NAPA;ARF4;CD163;RAB5C;SORT1;HP;KIF23;KIF11;F5;KIF15;IGLV4-60;CENPE;KIF18A;BLOC1S1;KIF4A;KIF1B;KIF2C;CD59;KIF20A;APOL1;RAB8A;TXNDC5;CHMP5"]
["Phosphorylation of the APC/C Homo sapiens R-HSA-176412","3/19",0.016180286210439623,0.06173643185148321,0,0,6.373686514886165,26.284838937262155,"CCNB1;UBE2C;CDK1"]
["MAPK6/MAPK4 signaling Homo sapiens R-HSA-5687128","7/92",0.016634530903580916,0.0631630014020029,0,0,2.8091503267973854,11.507051044925749,"PSMA4;CDC42EP3;PSME1;CDK1;PSME2;PSMB8;PSMB9"]
["Fanconi Anemia Pathway Homo sapiens R-HSA-6783310","4/35",0.01738394674514521,0.06569126029655833,0,0,4.390492359932089,17.791188701593313,"FANCI;FANCL;ZBTB32;ATRIP"]
["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Homo sapiens R-HSA-141405","3/20",0.018637593366478866,0.06975784945739233,0,0,5.998454723395488,23.88929335646545,"CDC20;UBE2C;BUB1B"]
["Inactivation of APC/C via direct inhibition of the APC/C complex Homo sapiens R-HSA-141430","3/20",0.018637593366478866,0.06975784945739233,0,0,5.998454723395488,23.88929335646545,"CDC20;UBE2C;BUB1B"]
["Golgi Associated Vesicle Biogenesis Homo sapiens R-HSA-432722","5/54",0.0190602849488891,0.07000646714872352,0,0,3.474947096589075,13.761306291561542,"NAPA;RAB5C;BLOC1S1;SORT1;TXNDC5"]
["Stabilization of p53 Homo sapiens R-HSA-69541","5/54",0.0190602849488891,0.07000646714872352,0,0,3.474947096589075,13.761306291561542,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["AUF1 (hnRNP D0) binds and destabilizes mRNA Homo sapiens R-HSA-450408","5/54",0.0190602849488891,0.07000646714872352,0,0,3.474947096589075,13.761306291561542,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Degradation of AXIN Homo sapiens R-HSA-4641257","5/54",0.0190602849488891,0.07000646714872352,0,0,3.474947096589075,13.761306291561542,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["TNFR2 non-canonical NF-kB pathway Homo sapiens R-HSA-5668541","7/95",0.019515787330486305,0.07134608763610342,0,0,2.712962962962963,10.679664255025324,"PSMA4;PSME1;PSME2;TNFRSF1B;PSMB8;TNFSF13B;PSMB9"]
["Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Homo sapiens R-HSA-5362768","5/55",0.02048716621194941,0.07455052149348258,0,0,3.405272407732865,13.239551425485676,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Homo sapiens R-HSA-110313","4/37",0.0209699005364592,0.07560707257640793,0,0,4.123976608187134,15.937797037261406,"KIAA0101;TRIM25;UBE2L6;ISG15"]
["Activation of ATR in response to replication stress Homo sapiens R-HSA-176187","4/37",0.0209699005364592,0.07560707257640793,0,0,4.123976608187134,15.937797037261406,"CHEK1;MCM4;MCM10;ATRIP"]
["Mitotic Spindle Checkpoint Homo sapiens R-HSA-69618","3/21",0.021289906371192012,0.07641034889386719,0,0,5.664915353181553,21.807217401125776,"CDC20;UBE2C;BUB1B"]
["Hh mutants abrogate ligand secretion Homo sapiens R-HSA-5387390","5/57",0.02354601737858021,0.08412349845256385,0,0,3.2739624171961608,12.273425681043795,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Collagen degradation Homo sapiens R-HSA-1442490","4/39",0.02497754600798789,0.08843401424449765,0,0,3.8879197994987473,14.345561009532773,"CTSL;MMP8;CTSD;MMP9"]
["Presynaptic phase of homologous DNA pairing and strand exchange Homo sapiens R-HSA-5693616","4/39",0.02497754600798789,0.08843401424449765,0,0,3.8879197994987473,14.345561009532773,"CHEK1;RBBP8;BRCA1;ATRIP"]
["NIK-->noncanonical NF-kB signaling Homo sapiens R-HSA-5676590","5/58",0.025180019474696426,0.08875110003188964,0,0,3.2120237424146962,11.825722192508232,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Organic cation transport Homo sapiens R-HSA-549127","2/9",0.025895541692988487,0.0908656061191471,0,0,9.6998001998002,35.44000925995988,"SLC22A4;SLC22A16"]
["Metabolism of proteins Homo sapiens R-HSA-392499","42/1074",0.02632370484499561,0.09195747559185133,0,0,1.4071297429620564,5.11813249931048,"HIST2H2AA3;TOP2A;NAPA;ARF4;SP100;GALNT14;PGAP1;HIST1H2BO;HIST1H2BK;UBE2L6;CSF2RB;TXN;BRCA1;AURKB;C1GALT1C1;GNG5;SEC61G;NEU1;CCL2;FBXO6;CTSG;CD59;CTSD;HIST1H2AC;STAT3;HIST1H2AJ;RAB27A;PDIA6;HIST2H2BE;PML;PDIA5;F5;NAGK;GLB1;BIRC5;HIST1H2BH;ATF3;HIST1H2BD;MSRB1;HIST1H2BC;B4GALT5;LTF"]
["RAF-independent MAPK1/3 activation Homo sapiens R-HSA-112409","3/23",0.02718059312848323,0.0945307353937514,0,0,5.097898423817863,18.37920873427671,"DUSP5;CDK1;JAK2"]
["Complement cascade Homo sapiens R-HSA-166658","6/80",0.027395363191807708,0.09485795360687603,0,0,2.762466692044157,9.937646590240185,"C1QB;CFHR3;C3AR1;CD59;IGLV4-60;C1QC"]
["Glycosphingolipid metabolism Homo sapiens R-HSA-1660662","4/41",0.029416192670600763,0.10100151185166704,0,0,3.6773826458036982,12.967223404840656,"UGCG;GM2A;GLB1;NEU1"]
["Hemostasis Homo sapiens R-HSA-109582","24/552",0.029426649127266866,0.10100151185166704,0,0,1.5618181818181818,5.506743793082294,"LGALS3BP;CD63;CAV1;KIF23;CSF2RB;SLC3A2;KIF11;F5;KIF15;CENPE;CEACAM1;KIF18A;GNA15;SELL;GNG5;KIF4A;IRF7;SERPING1;OLR1;KIF1B;KIF2C;KIF20A;CEACAM8;JAK2"]
["Regulation of TP53 Activity Homo sapiens R-HSA-5633007","9/151",0.03036535310093321,0.10248606762279384,0,0,2.1632307117038514,7.5593080959575545,"CCNA2;TPX2;CHEK1;CDK1;RBBP8;BRCA1;ATRIP;AURKB;PML"]
["Degradation of beta-catenin by the destruction complex Homo sapiens R-HSA-195253","6/82",0.03045256000272029,0.10248606762279384,0,0,2.6894922164566344,9.390591261584037,"PSMA4;PSME1;PSME2;PSMB8;RBX1;PSMB9"]
["Chromatin organization Homo sapiens R-HSA-4839726","12/226",0.0305041845310786,0.10248606762279384,0,0,1.9169188811653972,6.689838731370391,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;ASH2L;HIST1H2BH;JAK2;HIST2H2BE;HIST1H2AC;HIST1H2BD;SAP30;HIST1H2BC"]
["Chromatin modifying enzymes Homo sapiens R-HSA-3247509","12/226",0.0305041845310786,0.10248606762279384,0,0,1.9169188811653972,6.689838731370391,"HIST2H2AA3;HIST1H2BO;HIST1H2AJ;HIST1H2BK;ASH2L;HIST1H2BH;JAK2;HIST2H2BE;HIST1H2AC;HIST1H2BD;SAP30;HIST1H2BC"]
["Dectin-1 mediated noncanonical NF-kB signaling Homo sapiens R-HSA-5607761","5/61",0.03051111936861801,0.10248606762279384,0,0,3.0394802912377603,10.606765231723296,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["E2F-enabled inhibition of pre-replication complex formation Homo sapiens R-HSA-113507","2/10",0.03176267032999295,0.10501788344671825,0,0,8.486888111888112,29.275211345420935,"CCNB1;CDK1"]
["MAPK3 (ERK1) activation Homo sapiens R-HSA-110056","2/10",0.03176267032999295,0.10501788344671825,0,0,8.486888111888112,29.275211345420935,"CDK1;JAK2"]
["MASTL Facilitates Mitotic Progression Homo sapiens R-HSA-2465910","2/10",0.03176267032999295,0.10501788344671825,0,0,8.486888111888112,29.275211345420935,"CCNB1;CDK1"]
["Homologous DNA Pairing and Strand Exchange Homo sapiens R-HSA-5693579","4/42",0.031799308219235295,0.10501788344671825,0,0,3.5804247460757157,12.346417118346295,"CHEK1;RBBP8;BRCA1;ATRIP"]
["G0 and Early G1 Homo sapiens R-HSA-1538133","3/25",0.033848980790572004,0.11039543112609793,0,0,4.633975481611208,15.689929154192937,"TOP2A;CCNA2;CDK1"]
["Regulation of IFNA signaling Homo sapiens R-HSA-912694","3/25",0.033848980790572004,0.11039543112609793,0,0,4.633975481611208,15.689929154192937,"STAT1;STAT2;USP18"]
["Synthesis and interconversion of nucleotide di- and triphosphates Homo sapiens R-HSA-499943","3/25",0.033848980790572004,0.11039543112609793,0,0,4.633975481611208,15.689929154192937,"RRM2;GLRX;TXN"]
["Asymmetric localization of PCP proteins Homo sapiens R-HSA-4608870","5/63",0.034430392006295434,0.11182763684689341,0,0,2.9343676140839947,9.885343441686597,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["Membrane Trafficking Homo sapiens R-HSA-199991","19/420",0.034979657286383935,0.11314407665472337,0,0,1.6242052526341804,5.445941707277756,"NAPA;ARF4;RAB5C;SORT1;KIF23;KIF11;F5;KIF15;CENPE;KIF18A;BLOC1S1;KIF4A;KIF1B;KIF2C;CD59;KIF20A;RAB8A;TXNDC5;CHMP5"]
["Hedgehog 'on' state Homo sapiens R-HSA-5632684","6/85",0.03544283480045382,0.114172410463757,0,0,2.5869584596184705,8.640012253901052,"PSMA4;PSME1;PSME2;PSMB8;RBX1;PSMB9"]
["Hedgehog ligand biogenesis Homo sapiens R-HSA-5358346","5/64",0.03650151754667835,0.11710282772118034,0,0,2.884483631705937,9.548798775661137,"PSMA4;PSME1;PSME2;PSMB8;PSMB9"]
["TAK1 activates NFkB by phosphorylation and activation of IKKs complex Homo sapiens R-HSA-445989","3/26",0.03747159282310807,0.1192415868783925,0,0,4.4322698545648365,14.556337252172533,"NFKBIA;NOD2;MYD88"]
["Regulation of Complement cascade Homo sapiens R-HSA-977606","3/26",0.03747159282310807,0.1192415868783925,0,0,4.4322698545648365,14.556337252172533,"CFHR3;C3AR1;CD59"]
["CASP8 activity is inhibited Homo sapiens R-HSA-5218900","2/11",0.03809516713665377,0.11929402936019867,0,0,7.5435120435120435,24.649691793512716,"TNFSF10;FAS"]
["Regulation by c-FLIP Homo sapiens R-HSA-3371378","2/11",0.03809516713665377,0.11929402936019867,0,0,7.5435120435120435,24.649691793512716,"TNFSF10;FAS"]
["Dimerization of procaspase-8 Homo sapiens R-HSA-69416","2/11",0.03809516713665377,0.11929402936019867,0,0,7.5435120435120435,24.649691793512716,"TNFSF10;FAS"]
["Recruitment of NuMA to mitotic centrosomes Homo sapiens R-HSA-380320","2/11",0.03809516713665377,0.11929402936019867,0,0,7.5435120435120435,24.649691793512716,"CCNB1;CDK1"]
["Regulation of PLK1 Activity at G2/M Transition Homo sapiens R-HSA-2565942","6/87",0.03904539804305381,0.12178445580095355,0,0,2.5228221178925403,8.181588462490009,"CCNB2;CCNB1;CDK1;NEK2;MAPRE1;RAB8A"]
["RMTs methylate histone arginines Homo sapiens R-HSA-3214858","4/45",0.039610288425755036,0.12257356969544665,0,0,3.317928968763372,10.712485731702554,"HIST2H2AA3;HIST1H2AJ;JAK2;HIST1H2AC"]
["Diseases of metabolism Homo sapiens R-HSA-5668914","4/45",0.039610288425755036,0.12257356969544665,0,0,3.317928968763372,10.712485731702554,"TCN2;IDH1;CSF2RB;GYG1"]
["FCERI mediated NF-kB activation Homo sapiens R-HSA-2871837","7/111",0.04085143000445146,0.12591852542548568,0,0,2.293684710351377,7.334775821545765,"NFKBIA;PSMA4;PSME1;PSME2;PSMB8;IGLV4-60;PSMB9"]
["Interleukin-6 family signaling Homo sapiens R-HSA-6783589","3/27",0.041283899785005476,0.1267544735586496,0,0,4.247373029772329,13.537578538888015,"STAT1;STAT3;JAK2"]
["Scavenging of heme from plasma Homo sapiens R-HSA-2168880","4/46",0.04243536820913518,0.12978287709097378,0,0,3.238763575605681,10.233758051257135,"CD163;HP;APOL1;IGLV4-60"]
["Unwinding of DNA Homo sapiens R-HSA-176974","2/12",0.044861585920064465,0.1361436545682265,0,0,6.788811188811189,21.073647095407654,"GINS2;MCM4"]
["Pyrimidine catabolism Homo sapiens R-HSA-73621","2/12",0.044861585920064465,0.1361436545682265,0,0,6.788811188811189,21.073647095407654,"UPP1;TYMP"]
["Recognition of DNA damage by PCNA-containing replication complex Homo sapiens R-HSA-110314","3/28",0.045283484505365054,0.13689545700468048,0,0,4.077267950963223,12.61838142458657,"ZBTB32;DTL;RBX1"]
["MyD88:Mal cascade initiated on plasma membrane Homo sapiens R-HSA-166058","6/92",0.049040881175749604,0.14600807804598176,0,0,2.375532263347527,7.162469747898909,"NFKBIA;LY96;NOD2;CD14;MYD88;TLR2"]
["Toll Like Receptor TLR1:TLR2 Cascade Homo sapiens R-HSA-168179","6/92",0.049040881175749604,0.14600807804598176,0,0,2.375532263347527,7.162469747898909,"NFKBIA;LY96;NOD2;CD14;MYD88;TLR2"]
["Toll Like Receptor TLR6:TLR2 Cascade Homo sapiens R-HSA-168188","6/92",0.049040881175749604,0.14600807804598176,0,0,2.375532263347527,7.162469747898909,"NFKBIA;LY96;NOD2;CD14;MYD88;TLR2"]
["Toll Like Receptor 2 (TLR2) Cascade Homo sapiens R-HSA-181438","6/92",0.049040881175749604,0.14600807804598176,0,0,2.375532263347527,7.162469747898909,"NFKBIA;LY96;NOD2;CD14;MYD88;TLR2"]
["trans-Golgi Network Vesicle Budding Homo sapiens R-HSA-199992","5/70",0.05051658437880431,0.14927080948022628,0,0,2.6174124645126398,7.81416344673275,"NAPA;RAB5C;BLOC1S1;SORT1;TXNDC5"]
["Clathrin derived vesicle budding Homo sapiens R-HSA-421837","5/70",0.05051658437880431,0.14927080948022628,0,0,2.6174124645126398,7.81416344673275,"NAPA;RAB5C;BLOC1S1;SORT1;TXNDC5"]
["Mitotic Telophase/Cytokinesis Homo sapiens R-HSA-68884","2/13",0.052031896699569924,0.1509117003906345,0,0,6.171328671328672,18.2418202392564,"KIF23;KIF20A"]
["Initiation of Nuclear Envelope Reformation Homo sapiens R-HSA-2995383","2/13",0.052031896699569924,0.1509117003906345,0,0,6.171328671328672,18.2418202392564,"VRK2;LMNB1"]
["Nuclear Envelope Reassembly Homo sapiens R-HSA-2995410","2/13",0.052031896699569924,0.1509117003906345,0,0,6.171328671328672,18.2418202392564,"VRK2;LMNB1"]
["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Homo sapiens R-HSA-6804116","2/13",0.052031896699569924,0.1509117003906345,0,0,6.171328671328672,18.2418202392564,"CCNA2;CDKN1A"]
["DEx/H-box helicases activate type I IFN and inflammatory cytokines production Homo sapiens R-HSA-3134963","2/13",0.052031896699569924,0.1509117003906345,0,0,6.171328671328672,18.2418202392564,"IRF7;MYD88"]
["SUMO E3 ligases SUMOylate target proteins Homo sapiens R-HSA-3108232","6/96",0.058073463119635335,0.1678152279854168,0,0,2.2694835680751173,6.459055684917819,"TOP2A;SP100;BIRC5;BRCA1;AURKB;PML"]
["Organic cation/anion/zwitterion transport Homo sapiens R-HSA-549132","2/14",0.059577430565524,0.17090460008942285,0,0,5.656759906759906,15.954769461444204,"SLC22A4;SLC22A16"]
[]
["Biocarta pathways"]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Hemoglobin's Chaperone Homo sapiens h ahspPathway","1/13",0.0358050737240218,0.1153124525629414,0,0,30.2,100.5559032787779,"HBA2"]
["IL12 and Stat4 Dependent Signaling Pathway in Th1 Development Homo sapiens h IL12Pathway","1/15",0.041200627604441056,0.1153124525629414,0,0,25.883116883116884,82.54907099640234,"IL18R1"]
["Bone Remodeling Homo sapiens h ranklPathway","1/16",0.043887273641335565,0.1153124525629414,0,0,24.156363636363636,75.5159546794018,"IRF9"]
["Map Kinase Inactivation of SMRT Corepressor Homo sapiens h egfr smrtePathway","1/17",0.04656652576934638,0.1153124525629414,0,0,22.645454545454545,69.45074052559761,"MAP2K4"]
["TNFR1 Signaling Pathway Homo sapiens h tnfr1Pathway","1/17",0.04656652576934638,0.1153124525629414,0,0,22.645454545454545,69.45074052559761,"MAP2K4"]
["FAS signaling pathway ( CD95 ) Homo sapiens h fasPathway","1/20",0.054560117949919246,0.1153124525629414,0,0,19.066985645933013,55.45541451142644,"MAP2K4"]
["EGF Signaling Pathway Homo sapiens h egfPathway","1/20",0.054560117949919246,0.1153124525629414,0,0,19.066985645933013,55.45541451142644,"MAP2K4"]
["NF-kB Signaling Pathway Homo sapiens h nfkbPathway","1/21",0.05720999346183073,0.1153124525629414,0,0,18.112727272727273,51.82099606513529,"IL1R1"]
["Inhibition of Cellular Proliferation by Gleevec Homo sapiens h gleevecpathway","1/22",0.05985257433019706,0.1153124525629414,0,0,17.24935064935065,48.57194341390608,"MAP2K4"]

{"sheet":"SLE_down_enriched_pathways","index":4,"n_rows":206,"n_cols":9,"rows_kept":206,"merged":[[1,0,1,8],[121,0,121,8],[193,0,193,11]],"flags":["formulas_cached_only"]}
[]
["KEGG Pathways"]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Herpes simplex virus 1 infection","66/492",2.7486624733473585e-12,7.311442179103973e-10,0,0,2.897965571205008,77.14357311339678,"ZNF331;ZNF571;ZNF43;ZNF45;IKBKB;ZNF529;ZNF606;ZNF83;AKT2;ZNF84;AKT3;ZNF248;ZNF600;ZNF324;ZNF764;ZFP37;ZNF680;ZNF10;TSC1;ZNF12;ZNF14;ZNF91;ZNF439;TRAF5;ZNF879;ZNF559;ZNF597;SRSF8;ZNF432;ZNF398;ZNF112;ZNF551;ZNF430;ZNF671;ZNF550;ZNF470;ZNF23;PIK3R1;ZNF7;ZNF708;HLA-DMB;ZNF506;ZNF548;ZNF426;ZNF624;ZNF227;ZNF304;ZNF623;ZNF700;ZNF589;ZNF302;ZNF783;ZNF540;ZNF264;ZNF383;ZNF184;EIF2AK4;ZNF736;ZNF813;ZNF614;ZNF415;ZNF853;ZNF256;ZNF212;ZNF211;ZFP28"]
["Ribosome","22/153",1.8040423552545877e-05,0.0023993763324886017,0,0,3.055546532402144,33.37541566767985,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL10A;RPL3L;RPS14;RPL7A;RPS17;RPS16;RPL13;RPS20;RPL15;RPS2;RPS27A;RSL24D1;RPL17"]
["T cell receptor signaling pathway","11/101",0.01751194869839713,0.9999955996293995,0,0,2.2051461988304095,8.91953378098465,"IL4;IKBKB;DLG1;CD40LG;AKT2;AKT3;NFATC1;PIK3R1;PLCG1;CD247;MALT1"]
["Asthma","5/31",0.022006912673202345,0.9999955996293995,0,0,3.4615384615384617,13.210610755015097,"IL4;HLA-DMB;CD40LG;FCER1A;MS4A2"]
["Hematopoietic cell lineage","10/97",0.031991610799014025,0.9999955996293995,0,0,2.0721522603898817,7.132931542564087,"IL4;FCER2;HLA-DMB;IL11RA;IL3RA;KIT;DNTT;ITGA6;CD1C;CD44"]
["Fc epsilon RI signaling pathway","7/68",0.06678484524940183,0.9999955996293995,0,0,2.065683164293863,5.590315157608877,"IL4;AKT2;AKT3;FCER1A;PIK3R1;PLCG1;MS4A2"]
["Phosphatidylinositol signaling system","9/99",0.07784926299193312,0.9999955996293995,0,0,1.800764087870105,4.597316227691836,"ITPKB;INPP4B;DGKD;DGKA;SACM1L;PI4KA;ITPR3;PIK3R1;PLCG1"]
["Hypertrophic cardiomyopathy (HCM)","8/85",0.07958041394937751,0.9999955996293995,0,0,1.870427282641023,4.7340276461661315,"PRKAB2;CACNB3;TPM2;CACNA2D3;CACNA2D2;ITGA6;CACNA2D4;EMD"]
["FoxO signaling pathway","11/132",0.08991004703902866,0.9999955996293995,0,0,1.6374945628534143,3.944635298967942,"IKBKB;RBL2;PRKAB2;SMAD4;AKT2;AKT3;S1PR1;PIK3R1;SIRT1;IGF1R;TGFBR2"]
["Phospholipase D signaling pathway","12/148",0.0923940638992996,0.9999955996293995,0,0,1.5895875591615958,3.7859088407300603,"CYTH3;DGKD;DGKA;AKT2;AKT3;KIT;FCER1A;TSC1;PIK3R1;PLCG1;MS4A2;CYTH1"]
["Pancreatic cancer","7/75",0.10045807085695328,0.9999955996293995,0,0,1.8523523804183255,4.25673326641047,"IKBKB;SMAD4;AKT2;AKT3;PIK3R1;TGFBR2;ARHGEF6"]
["TGF-beta signaling pathway","8/90",0.10254905541392029,0.9999955996293995,0,0,1.7559113759076521,3.998937159885958,"SMAD4;ACVR1C;ID3;NEO1;SMAD5;ACVR2A;TGFBR2;BMPR1A"]
["Chronic myeloid leukemia","7/76",0.10590746281096107,0.9999955996293995,0,0,1.8254099832829058,4.098391434447041,"IKBKB;SMAD4;AKT2;AKT3;PIK3R1;CBL;TGFBR2"]
["Intestinal immune network for IgA production","5/48",0.10772250509084524,0.9999955996293995,0,0,2.09114243356272,4.659476786236515,"IL4;HLA-DMB;CD40LG;CCR9;CCL28"]
["Signaling pathways regulating pluripotency of stem cells","11/139",0.1176777030233647,0.9999955996293995,0,0,1.5473684210526315,3.3110678009704175,"SMAD4;ACVR1C;APC;AKT2;AKT3;ID3;PIK3R1;SMAD5;ACVR2A;IGF1R;BMPR1A"]
["Small cell lung cancer","8/93",0.11792626912770889,0.9999955996293995,0,0,1.6936686124831613,3.620548089314695,"IKBKB;AKT2;AKT3;TRAF5;ITGA6;TRAF1;PIK3R1;FHIT"]
["N-Glycan biosynthesis","5/50",0.12262498068051884,0.9999955996293995,0,0,1.9979913310075061,4.193033595294325,"B4GALT1;MGAT4A;MAN1C1;ALG10;ALG10B"]
["NF-kappa B signaling pathway","8/95",0.1288229345603807,0.9999955996293995,0,0,1.6545582170746689,3.3907133184674203,"IKBKB;CD40LG;CSNK2A2;TRAF5;TRAF1;LTB;PLCG1;MALT1"]
["Aminoacyl-tRNA biosynthesis","6/66",0.13456704463699198,0.9999955996293995,0,0,1.7984761904761906,3.607190622113264,"QARS;TARSL2;NARS2;IARS2;HARS;PSTK"]
["Non-small cell lung cancer","6/66",0.13456704463699198,0.9999955996293995,0,0,1.7984761904761906,3.607190622113264,"EML4;AKT2;AKT3;PIK3R1;PLCG1;FHIT"]
["Cellular senescence","12/160",0.14019373333593946,0.9999955996293995,0,0,1.4597701149425288,2.868054142912427,"RBL2;AKT2;AKT3;TSC1;ITPR3;NFATC1;RAD1;PIK3R1;ETS1;SIRT1;TGFBR2;SLC25A6"]
["AGE-RAGE signaling pathway in diabetic complications","8/100",0.15821828156368026,0.9999955996293995,0,0,1.5642217059409227,2.8840801815751433,"SMAD4;AKT2;AKT3;VEGFB;NFATC1;PIK3R1;PLCG1;TGFBR2"]
["Regulation of lipolysis in adipocytes","5/55",0.16368397765967102,0.9999955996293995,0,0,1.7977164605137963,3.2535390260165427,"AKT2;PDE3B;AKT3;ADRB2;PIK3R1"]
["Prolactin signaling pathway","6/70",0.16386082216257358,0.9999955996293995,0,0,1.6857142857142857,3.0490152443392606,"GALT;TH;AKT2;AKT3;PIK3R1;SOCS5"]
["Colorectal cancer","7/86",0.16856060038626589,0.9999955996293995,0,0,1.5935007421172667,2.837164247870623,"SMAD4;APC;AKT2;AKT3;PIK3R1;APPL1;TGFBR2"]
["Longevity regulating pathway","8/102",0.17079115734346384,0.9999955996293995,0,0,1.5307779762871527,2.7053649977770986,"PRKAB2;AKT2;AKT3;TSC1;PIK3R1;SIRT1;IGF1R;APPL1"]
["B cell receptor signaling pathway","6/71",0.17157895260693037,0.9999955996293995,0,0,1.6596923076923078,2.925559137558859,"IKBKB;AKT2;AKT3;NFATC1;PIK3R1;MALT1"]
["Hepatocellular carcinoma","12/168",0.1782188438054042,0.9999955996293995,0,0,1.3843206601827291,2.387597402010837,"SMAD4;SMARCC2;PHF10;APC;GSTA4;AKT2;AKT3;GSTA1;PIK3R1;PLCG1;IGF1R;TGFBR2"]
["Arrhythmogenic right ventricular cardiomyopathy (ARVC)","6/72",0.17944433840911153,0.9999955996293995,0,0,1.6344588744588744,2.8078209016478457,"CACNB3;CACNA2D3;CACNA2D2;ITGA6;CACNA2D4;EMD"]
["mTOR signaling pathway","11/152",0.18046088329395304,0.9999955996293995,0,0,1.403732736095558,2.403529077519308,"IKBKB;WDR59;AKT2;NPRL2;AKT3;RPS6;TSC1;PIK3R1;ATP6V1E2;EIF4B;IGF1R"]
["AMPK signaling pathway","9/120",0.1834956493681617,0.9999955996293995,0,0,1.4584527220630372,2.4729003992990264,"PRKAB2;AKT2;AKT3;TSC1;PIK3R1;EEF2;ACACB;SIRT1;IGF1R"]
["Insulin signaling pathway","10/137",0.1880313448712572,0.9999955996293995,0,0,1.4164947832763735,2.3671704438388472,"IKBKB;PRKAB2;AKT2;AKT3;RPS6;PDE3B;TSC1;PIK3R1;CBL;ACACB"]
["Inositol phosphate metabolism","6/74",0.19559416555163472,0.9999955996293995,0,0,1.586218487394958,2.5882538823661787,"ITPKB;INPP4B;ALDH6A1;SACM1L;PI4KA;PLCG1"]
["Carbohydrate digestion and absorption","4/44",0.20134942967110817,0.9999955996293995,0,0,1.796958174904943,2.8800089896705248,"AKT2;AKT3;ATP1A3;PIK3R1"]
["Glioma","6/75",0.20386687032260672,0.9999955996293995,0,0,1.5631469979296067,2.4858540609632778,"CAMK1D;AKT2;AKT3;PIK3R1;PLCG1;IGF1R"]
["Th17 cell differentiation","8/107",0.20407346225023237,0.9999955996293995,0,0,1.4530804225460714,2.3093447385771584,"IL4;IKBKB;SMAD4;HLA-DMB;NFATC1;PLCG1;CD247;TGFBR2"]
["Dilated cardiomyopathy (DCM)","7/91",0.20483378714746328,0.9999955996293995,0,0,1.498252303781379,2.375563563711765,"CACNB3;TPM2;CACNA2D3;CACNA2D2;ITGA6;CACNA2D4;EMD"]
["Insulin resistance","8/108",0.21102292495079578,0.9999955996293995,0,0,1.4384732824427482,2.2379601937650375,"IKBKB;PRKAB2;TBC1D4;AKT2;AKT3;PIK3R1;ACACB;SLC27A5"]
["Cytokine-cytokine receptor interaction","19/294",0.2125773384221851,0.9999955996293995,0,0,1.2438362409047077,1.9260174949994222,"IL11RA;CXCR5;IL16;CXCR6;ACVR2A;TNFRSF10D;TGFBR2;EDAR;IL4;CD40LG;ACVR1C;IL3RA;CCR9;ACKR3;TNFRSF25;CCR6;LTB;CCL28;BMPR1A"]
["Circadian rhythm","3/31",0.22342609047442125,0.9999955996293995,0,0,1.9247049247049246,2.8845064043384565,"PRKAB2;CRY1;CLOCK"]
["RNA polymerase","3/31",0.22342609047442125,0.9999955996293995,0,0,1.9247049247049246,2.8845064043384565,"POLR2B;POLR1C;POLR2G"]
["Selenocompound metabolism","2/17",0.22548376909804146,0.9999955996293995,0,0,2.394560404807084,3.566714724392133,"CTH;PSTK"]
["Cardiac muscle contraction","6/78",0.22940310149518572,0.9999955996293995,0,0,1.4977777777777779,2.205140110288524,"CACNB3;TPM2;CACNA2D3;CACNA2D2;ATP1A3;CACNA2D4"]
["Autophagy","9/128",0.23516010026068648,0.9999955996293995,0,0,1.3598275986612411,1.9683351089792303,"ATG16L1;AKT2;ATG9B;AKT3;TSC1;PIK3R1;EIF2AK4;IGF1R;ATG2B"]
["Adrenergic signaling in cardiomyocytes","10/145",0.2367263815960755,0.9999955996293995,0,0,1.3319878195595214,1.9191950665090487,"CACNB3;RPS6KA5;AKT2;TPM2;AKT3;CACNA2D3;CACNA2D2;ATP1A3;CACNA2D4;ADRB2"]
["D-Glutamine and D-glutamate metabolism","1/5",0.23757595242416776,0.9999955996293995,0,0,4.488151658767772,6.450676340679195,"GLS"]
["Propanoate metabolism","3/32",0.23762948378703014,0.9999955996293995,0,0,1.8582375478927202,2.6703665342989273,"ALDH6A1;BCKDHB;ACACB"]
["Natural killer cell mediated cytotoxicity","9/131",0.25577092777405164,0.9999955996293995,0,0,1.3261778383202594,1.8082077400274326,"NCR3;SH2D1B;NFATC1;KIR3DL1;PIK3R1;PLCG1;KIR3DL2;CD247;CD244"]
["Central carbon metabolism in cancer","5/65",0.2586176000141292,0.9999955996293995,0,0,1.4973041547732318,2.0249612602849414,"AKT2;AKT3;KIT;PIK3R1;GLS"]
["Proteoglycans in cancer","13/201",0.2649724922400861,0.9999955996293995,0,0,1.2434874849554272,1.6515121147692189,"DDX5;RPS6;ITPR3;ANK3;PIK3R1;CBL;IGF1R;AKT2;AKT3;PDCD4;PLCG1;CD44;EIF4B"]
["Choline metabolism in cancer","7/99",0.2681441981779811,0.9999955996293995,0,0,1.3673892319807683,1.7997992624568413,"DGKD;DGKA;AKT2;AKT3;TSC1;PIK3R1;PLCG1"]
["Acute myeloid leukemia","5/66",0.2687856779810544,0.9999955996293995,0,0,1.4726801952863002,1.9348675513468683,"IKBKB;AKT2;AKT3;KIT;PIK3R1"]
["HIF-1 signaling pathway","7/100",0.27641819141698404,0.9999955996293995,0,0,1.3526143690355381,1.7392461657636273,"AKT2;AKT3;RPS6;PIK3R1;PLCG1;ENO2;IGF1R"]
["Oxytocin signaling pathway","10/153",0.2894637970746897,0.9999955996293995,0,0,1.2569361804543449,1.5582552604518798,"PRKAB2;CACNB3;CAMK1D;NPR2;CACNA2D3;CACNA2D2;ITPR3;NFATC1;CACNA2D4;EEF2"]
["Neurotrophin signaling pathway","8/119",0.2926441864709831,0.9999955996293995,0,0,1.2951653944020356,1.5914963724708358,"IKBKB;RPS6KA5;AKT2;AKT3;MATK;PIK3R1;PLCG1;SH2B1"]
["Apelin signaling pathway","9/137",0.2985819210701004,0.9999955996293995,0,0,1.2636103151862463,1.5273396135759474,"PRKAB2;SMAD4;AKT2;AKT3;RPS6;PDE3B;TFAM;ITPR3;NRF1"]
["Adipocytokine signaling pathway","5/69",0.2997648599295728,0.9999955996293995,0,0,1.4034253092293054,1.6907863416191544,"IKBKB;PRKAB2;AKT2;AKT3;ACACB"]
["Chagas disease (American trypanosomiasis)","7/103",0.30160565320854327,0.9999955996293995,0,0,1.3101366380680013,1.5703754967994725,"IKBKB;GNAL;AKT2;AKT3;PIK3R1;CD247;TGFBR2"]
["Glucagon signaling pathway","7/103",0.30160565320854327,0.9999955996293995,0,0,1.3101366380680013,1.5703754967994725,"PRKAB2;AKT2;AKT3;PDE3B;ITPR3;ACACB;SIRT1"]
["C-type lectin receptor signaling pathway","7/104",0.310107191580534,0.9999955996293995,0,0,1.2965612807484792,1.5180622599392524,"IKBKB;AKT2;AKT3;ITPR3;NFATC1;PIK3R1;MALT1"]
["Aldosterone-regulated sodium reabsorption","3/37",0.3103272292139428,0.9999955996293995,0,0,1.5845483492542316,1.8541243276311454,"ATP1A3;PIK3R1;NR3C2"]
["Fanconi anemia pathway","4/54",0.318438331441116,0.9999955996293995,0,0,1.4368060836501901,1.6441751972341903,"REV1;FANCC;FAN1;FANCF"]
["Allograft rejection","3/38",0.3250241365618511,0.9999955996293995,0,0,1.5391941391941393,1.7298323115541046,"IL4;HLA-DMB;CD40LG"]
["Adherens junction","5/72",0.33126516020763164,0.9999955996293995,0,0,1.3403723532669667,1.4808918116710472,"SMAD4;YES1;CSNK2A2;IGF1R;TGFBR2"]
["Histidine metabolism","2/23",0.34465484164790805,0.9999955996293995,0,0,1.7098581368031083,1.821361100813287,"HDC;CARNS1"]
["Proximal tubule bicarbonate reclamation","2/23",0.34465484164790805,0.9999955996293995,0,0,1.7098581368031083,1.821361100813287,"ATP1A3;GLS"]
["Pyrimidine metabolism","4/57",0.35490792635143137,0.9999955996293995,0,0,1.3552622139321329,1.403911906498678,"NT5E;CMPK1;NME3;UCKL1"]
["Th1 and Th2 cell differentiation","6/92",0.3582576304088566,0.9999955996293995,0,0,1.2530232558139536,1.2862320226298567,"IKBKB;IL4;HLA-DMB;NFATC1;PLCG1;CD247"]
["TNF signaling pathway","7/110",0.3618910288300965,0.9999955996293995,0,0,1.2206447194276564,1.2406781087736176,"IKBKB;RPS6KA5;AKT2;AKT3;TRAF5;PIK3R1;TRAF1"]
["Endometrial cancer","4/58",0.36707769301250404,0.9999955996293995,0,0,1.3300943529080411,1.3329962939113165,"APC;AKT2;AKT3;PIK3R1"]
["Graft-versus-host disease","3/41",0.3690212160631949,0.9999955996293995,0,0,1.4174538911381016,1.4130614006650506,"HLA-DMB;KIR3DL1;KIR3DL2"]
["Human T-cell leukemia virus 1 infection","13/219",0.3725050292253053,0.9999955996293995,0,0,1.1337441472972847,1.119577719378018,"SMAD4;TBP;NFYB;NFATC1;PIK3R1;ETS1;TGFBR2;IKBKB;DLG1;HLA-DMB;AKT2;AKT3;SLC25A6"]
["VEGF signaling pathway","4/59",0.3792342559847713,0.9999955996293995,0,0,1.30584168683028,1.2661456341351458,"AKT2;AKT3;PIK3R1;PLCG1"]
["Antigen processing and presentation","5/77",0.3842854934291239,0.9999955996293995,0,0,1.2469605666560948,1.1925550912627856,"HLA-DMB;NFYB;RFXAP;KIR3DL1;KIR3DL2"]
["Dopaminergic synapse","8/131",0.3884432011292417,0.9999955996293995,0,0,1.1680630546763482,1.1045301431396672,"GNAL;TH;KIF5C;AKT2;AKT3;ITPR3;CLOCK;SLC18A2"]
["RNA degradation","5/79",0.4054857752364093,0.9999955996293995,0,0,1.2131303520456709,1.0950557508552201,"EXOSC6;DIS3L;PABPC1;ENO2;TOB2"]
["Thyroid hormone signaling pathway","7/116",0.4142790623042368,0.9999955996293995,0,0,1.1530859446742638,1.0161171711861376,"TBC1D4;AKT2;AKT3;ATP1A3;SLC16A10;PIK3R1;PLCG1"]
["Progesterone-mediated oocyte maturation","6/99",0.4249640429078788,0.9999955996293995,0,0,1.158279569892473,0.991198574228338,"AKT2;AKT3;PDE3B;PIK3R1;KIF22;IGF1R"]
["ABC transporters","3/45",0.42675918632521387,0.9999955996293995,0,0,1.2821869488536155,1.0918275652039926,"ABCB1;ABCB4;ABCC5"]
["Butanoate metabolism","2/28",0.43938447620739457,0.9999955996293995,0,0,1.3806743541088893,1.1354395955022465,"ACSM3;AACS"]
["Sphingolipid signaling pathway","7/119",0.4404028023629571,0.9999955996293995,0,0,1.1220209723546235,0.9201307019702836,"AKT2;AKT3;S1PR1;FCER1A;PIK3R1;MS4A2;S1PR5"]
["Taurine and hypotaurine metabolism","1/11",0.4494554537361845,0.9999955996293995,0,0,1.7946919431279622,1.435248405776977,"GGT7"]
["Mitophagy","4/65",0.451298938720257,0.9999955996293995,0,0,1.1770242473352863,0.936470297856974,"ATG9B;CSNK2A2;TOMM7;TBC1D17"]
["Fluid shear stress and atherosclerosis","8/139",0.4531865146946217,0.9999955996293995,0,0,1.0962647864343569,0.8676404162199964,"IKBKB;GSTA4;AKT2;AKT3;GSTA1;PIK3R1;ACVR2A;BMPR1A"]
["ErbB signaling pathway","5/85",0.4683025835244609,0.9999955996293995,0,0,1.1217887725975262,0.8510345591109317,"AKT2;AKT3;PIK3R1;PLCG1;CBL"]
["Valine leucine and isoleucine degradation","3/48",0.46881491605590947,0.9999955996293995,0,0,1.1965178854067744,0.9064188021974123,"ALDH6A1;BCKDHB;AACS"]
["Pentose phosphate pathway","2/30",0.4751616015840416,0.9999955996293995,0,0,1.2819192193006235,0.953876499944561,"TKTL1;ALDOC"]
["Epithelial cell signaling in Helicobacter pylori infection","4/68",0.4863456177224882,0.9999955996293995,0,0,1.1216730038022813,0.8085420124478602,"IKBKB;PLCG1;ATP6V1E2;JAM3"]
["Galactose metabolism","2/31",0.49252266320292326,0.9999955996293995,0,0,1.2376496761107112,0.8765218212688712,"GALT;B4GALT1"]
["beta-Alanine metabolism","2/31",0.49252266320292326,0.9999955996293995,0,0,1.2376496761107112,0.8765218212688712,"ALDH6A1;CARNS1"]
["MAPK signaling pathway","16/295",0.4926836480368417,0.9999955996293995,0,0,1.0292252550317067,0.7285762057499753,"CACNA2D3;VEGFB;CACNA2D2;NFATC1;CACNA2D4;DUSP8;IGF1R;TGFBR2;IKBKB;CACNB3;RPS6KA5;AKT2;AKT3;KIT;MAP3K4;MAP3K12"]
["Vibrio cholerae infection","3/50",0.49606808578947353,0.9999955996293995,0,0,1.1454809965448263,0.8030303940964418,"SLC12A2;PLCG1;ATP6V1E2"]
["Renal cell carcinoma","4/69",0.4978275052684492,0.9999955996293995,0,0,1.1043579994150337,0.7702915123400025,"AKT2;AKT3;PIK3R1;ETS1"]
["Cell adhesion molecules (CAMs)","8/145",0.5009835800874257,0.9999955996293995,0,0,1.047918872234914,0.7243026123939906,"CNTNAP2;HLA-DMB;CD40LG;CD6;NRCAM;ITGA6;NEO1;JAM3"]
["Fatty acid biosynthesis","1/13",0.5060896937822165,0.9999955996293995,0,0,1.4954186413902053,1.0184419527254203,"ACACB"]
["Non-homologous end-joining","1/13",0.5060896937822165,0.9999955996293995,0,0,1.4954186413902053,1.0184419527254203,"DNTT"]
["Osteoclast differentiation","7/127",0.5088576658038121,0.9999955996293995,0,0,1.0467747060692723,0.7071873168788205,"IKBKB;AKT2;AKT3;NFATC1;PIK3R1;LILRA4;TGFBR2"]
["Drug metabolism","6/108",0.5089169881608547,0.9999955996293995,0,0,1.0555742296918766,0.7130091089737876,"GSTA4;GSTA1;CMPK1;NME3;CYP2E1;UCKL1"]
["cGMP-PKG signaling pathway","9/166",0.5161910038667252,0.9999955996293995,0,0,1.0286167941160367,0.6802020878445146,"AKT2;NPR2;AKT3;PDE3B;ATP1A3;ITPR3;NFATC1;ADRB2;SLC25A6"]
["Salivary secretion","5/90",0.5190119014421113,0.9999955996293995,0,0,1.055521352213578,0.6922409477657543,"SLC12A2;ATP1A3;PRH2;ITPR3;ADRB2"]
["Fructose and mannose metabolism","2/33",0.5261306663771629,0.9999955996293995,0,0,1.1576788884128053,0.7434679599875548,"ENOSF1;ALDOC"]
["Fc gamma R-mediated phagocytosis","5/91",0.5289110345672496,0.9999955996293995,0,0,1.0431925298165645,0.664445873503784,"MARCKSL1;AKT2;AKT3;PIK3R1;PLCG1"]
["Bile secretion","4/72",0.531578497266473,0.9999955996293995,0,0,1.0554685752628048,0.6669552389298096,"ABCB1;ABCB4;ATP1A3;SLC27A5"]
["Melanoma","4/72",0.531578497266473,0.9999955996293995,0,0,1.0554685752628048,0.6669552389298096,"AKT2;AKT3;PIK3R1;IGF1R"]
["Autoimmune thyroid disease","3/53",0.5355768030198731,0.9999955996293995,0,0,1.0765811965811967,0.6722291161011418,"IL4;HLA-DMB;CD40LG"]
["Glycosaminoglycan biosynthesis","3/53",0.5355768030198731,0.9999955996293995,0,0,1.0765811965811967,0.6722291161011418,"B4GALT1;UST;XYLT1"]
["Metabolism of xenobiotics by cytochrome P450","4/74",0.5534430146947702,0.9999955996293995,0,0,1.0252036936447584,0.6065069032245654,"AKR7A2;GSTA4;GSTA1;CYP2E1"]
["Toxoplasmosis","6/113",0.55358251555541,0.9999955996293995,0,0,1.005981308411215,0.5948814719331241,"IKBKB;HLA-DMB;CD40LG;AKT2;AKT3;ITGA6"]
["Thiamine metabolism","1/15",0.5569029282086436,0.9999955996293995,0,0,1.2816519972918077,0.750233363135514,"THTPA"]
["Spliceosome","7/134",0.5662642584017207,0.9999955996293995,0,0,0.9887106580695526,0.5622742363164822,"DDX5;DDX46;SNRNP70;RP9;PRPF8;SF3B1;SRSF8"]
["Glutathione metabolism","3/56",0.57326313441335,0.9999955996293995,0,0,1.01548137397194,0.5650244435016774,"GGT7;GSTA4;GSTA1"]
["Prostate cancer","5/97",0.5862520272313827,0.9999955996293995,0,0,0.9748479708765978,0.5205741793438075,"IKBKB;AKT2;AKT3;PIK3R1;IGF1R"]
["Primary immunodeficiency","2/37",0.5886901925409311,0.9999955996293995,0,0,1.0251558687991325,0.5431841910685034,"CD40LG;RFXAP"]
["Pancreatic secretion","5/98",0.5954343985499426,0.9999955996293995,0,0,0.9643145800722304,0.4999624505848568,"CPA3;SLC12A2;TRPC1;ATP1A3;ITPR3"]
[]
[]
[]
[]
["Reactome pathways"]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Gene Expression Homo sapiens R-HSA-74160","162/1631",1.2563527313033843e-15,1.2299693239460132e-12,0,0,2.155623375258702,73.96065276198672,"RPL4;ZNF331;RPL5;ZNF571;CCNT2;RPL3;CCNT1;THUMPD1;TSEN2;RPL10A;TSEN54;NR3C2;GLS;EEF1B2;RPS14;FBL;RPS17;RPS16;TRIM28;HENMT1;ZNF606;AKT2;AKT3;NARS2;ZNF600;ZNF324;ZNF202;ZFP37;PRKAB2;ZNF680;RPS8;CSNK2A2;RPL22;RPS6;ZNF10;WDR75;RPSA;TSC1;ZNF12;POLRMT;ZNF14;ZNF439;RPP21;ZNF559;TFAM;ZNF432;ZNF398;ZNF28;ZNF430;ZNF551;ZNF671;ZNF550;DDX5;ZNF23;GSPT2;PRPF8;OSGEP;NUP160;ZNF708;ZNF767P;ZKSCAN8;PCBP2;SMYD2;ZNF548;ZNF426;COX11;ZNF700;ZNF304;RPRD1B;ZNF302;ZNF266;BANP;ZNF540;ZNF264;SMAD4;BRPF1;ZNF383;NR1D2;FANCC;EEF2;RPL3L;TNFRSF10D;QARS;JMY;ZNF415;TRMT13;RPS20;NOL11;ZNF256;ZNF770;PPP1R13B;DYRK2;CHD9;PHF20;SETD9;ZNF43;SMG9;ZNF45;RPL7A;ZNF529;SNRNP70;ZNF248;ZNF764;UTP15;WDR36;TBP;RPL13A;RPS3A;RABGGTB;SIRT1;TSN;ZNF75A;MED23;EEF1G;RBL2;POLR1C;PABPC1;CD44;ZNF597;ZNF112;RRN3;ZNF470;DDX20;NOL9;NR2C1;EXOSC6;TAF1D;POLR2B;ZNF506;ZNF624;RPL13;ZNF227;IARS2;POLR2G;LCMT2;HARS;ZNF589;RPL15;RPS2;RPS27A;ZNF500;SF3B1;RPL17;SRSF11;EIF4B;HNRNPA0;ZNF184;KRR1;GATAD2B;LRPPRC;TRIT1;EIF3M;EIF3L;PRKRA;ZNF736;ZNF614;RAD1;TAF4;EIF3D;ZNF212;ZNF211;ZFP28"]
["Generic Transcription Pathway Homo sapiens R-HSA-212436","92/812",2.932571194286845e-12,1.4354935996034106e-09,0,0,2.4155832180728445,64.14615425032893,"ZNF331;ZNF770;ZNF571;CCNT2;PPP1R13B;DYRK2;CCNT1;CHD9;PHF20;SETD9;ZNF43;ZNF45;NR3C2;GLS;TRIM28;ZNF529;ZNF606;AKT2;AKT3;ZNF248;ZNF600;ZNF324;ZNF764;ZNF202;ZFP37;PRKAB2;ZNF680;TBP;CSNK2A2;ZNF10;TSC1;ZNF12;RABGGTB;ZNF14;ZNF75A;MED23;RBL2;ZNF439;ZNF559;ZNF432;ZNF597;ZNF398;ZNF112;ZNF28;ZNF430;ZNF551;ZNF671;ZNF550;ZNF470;ZNF23;NR2C1;ZNF708;ZNF767P;POLR2B;ZNF506;ZKSCAN8;SMYD2;ZNF548;ZNF426;ZNF624;COX11;ZNF227;ZNF700;ZNF304;POLR2G;ZNF589;RPS27A;ZNF302;ZNF500;ZNF266;BANP;ZNF540;ZNF264;SMAD4;BRPF1;ZNF383;ZNF184;NR1D2;FANCC;GATAD2B;LRPPRC;TNFRSF10D;ZNF736;JMY;ZNF614;ZNF415;RAD1;TAF4;ZNF256;ZNF212;ZNF211;ZFP28"]
["Eukaryotic Translation Elongation Homo sapiens R-HSA-156842","24/89",2.039198184579816e-11,6.082536796286408e-09,0,0,6.754561717352415,166.2694762229599,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPS3A;RPSA;RPL10A;EEF2;RPL3L;EEF1B2;EEF1G;RPL7A;RPS14;RPS17;RPS16;RPL13;RPS20;RPL15;RPS2;RPS27A;RPL17"]
["L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827","26/106",3.106505003210627e-11,6.082536796286408e-09,0,0,5.9522330097087375,144.01390697585614,"RPL4;RPL5;RPL3;RPL10A;RPS14;RPL7A;RPS17;RPS16;RPL13;RPL15;RPS2;RPS27A;RPL17;EIF4B;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL3L;EIF3M;EIF3L;RPS20;PABPC1;EIF3D"]
["3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279","26/106",3.106505003210627e-11,6.082536796286408e-09,0,0,5.9522330097087375,144.01390697585614,"RPL4;RPL5;RPL3;RPL10A;RPS14;RPL7A;RPS17;RPS16;RPL13;RPL15;RPS2;RPS27A;RPL17;EIF4B;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL3L;EIF3M;EIF3L;RPS20;PABPC1;EIF3D"]
["Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689","24/96",1.1570864816401203e-10,1.887979442542796e-08,0,0,6.095607235142118,139.46716278066586,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPS3A;RPSA;RPL10A;RPL3L;RPL7A;RPS14;RPS17;EIF3M;RPS16;EIF3L;RPL13;RPS20;RPL15;RPS2;RPS27A;RPL17;EIF3D"]
["Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956","23/89",1.368262039362e-10,1.9136121950505684e-08,0,0,6.368535304643727,144.64414540922223,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPS3A;RPSA;RPL10A;GSPT2;RPL3L;RPL7A;RPS14;RPS17;RPS16;RPL13;RPS20;PABPC1;RPL15;RPS2;RPS27A;RPL17"]
["Cap-dependent Translation Initiation Homo sapiens R-HSA-72737","26/114",1.7719667002993455e-10,1.9275059995478434e-08,0,0,5.40882612533098,121.44848840607871,"RPL4;RPL5;RPL3;RPL10A;RPS14;RPL7A;RPS17;RPS16;RPL13;RPL15;RPS2;RPS27A;RPL17;EIF4B;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL3L;EIF3M;EIF3L;RPS20;PABPC1;EIF3D"]
["Eukaryotic Translation Initiation Homo sapiens R-HSA-72613","26/114",1.7719667002993455e-10,1.9275059995478434e-08,0,0,5.40882612533098,121.44848840607871,"RPL4;RPL5;RPL3;RPL10A;RPS14;RPL7A;RPS17;RPS16;RPL13;RPL15;RPS2;RPS27A;RPL17;EIF4B;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL3L;EIF3M;EIF3L;RPS20;PABPC1;EIF3D"]
["GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706","25/107",2.2856195412423075e-10,2.2172142513014925e-08,0,0,5.577701024342931,123.82057759828302,"RPL4;RPL5;RPL3;RPL10A;RPS14;RPL7A;RPS17;RPS16;RPL13;RPL15;RPS2;RPS27A;RPL17;EIF4B;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL3L;EIF3M;EIF3L;RPS20;EIF3D"]
["Peptide chain elongation Homo sapiens R-HSA-156902","22/84",2.596147016934237e-10,2.2172142513014925e-08,0,0,6.479752916952642,143.01995623073114,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPS3A;RPSA;RPL10A;EEF2;RPL3L;RPL7A;RPS14;RPS17;RPS16;RPL13;RPS20;RPL15;RPS2;RPS27A;RPL17"]
["Translation Homo sapiens R-HSA-72766","30/151",2.71772941936853e-10,2.2172142513014925e-08,0,0,4.548596007926151,100.18762207048314,"RPL4;RPL5;RPL3;RPL10A;GSPT2;EEF1B2;RPS14;RPL7A;RPS17;RPS16;RPL13;RPL15;RPS2;RPS27A;RPL17;EIF4B;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;EEF2;RPL3L;EEF1G;EIF3M;EIF3L;RPS20;PABPC1;EIF3D"]
["Selenocysteine synthesis Homo sapiens R-HSA-2408557","22/87",5.413336071761846e-10,3.785468581610604e-08,0,0,6.179705400981997,131.85628378114887,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPS3A;RPSA;RPL10A;RPL3L;RPL7A;RPS14;RPS17;RPS16;RPL13;RPS20;RPL15;RPS2;RPS27A;RPL17;PSTK"]
["Eukaryotic Translation Termination Homo sapiens R-HSA-72764","22/87",5.413336071761846e-10,3.785468581610604e-08,0,0,6.179705400981997,131.85628378114887,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPS3A;RPSA;RPL10A;GSPT2;RPL3L;RPL7A;RPS14;RPS17;RPS16;RPL13;RPS20;RPL15;RPS2;RPS27A;RPL17"]
["Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802","24/106",1.0380648986979591e-09,6.351659598908138e-08,0,0,5.349404424276801,110.65728526826028,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPSA;SMG9;RPS3A;RPL10A;GSPT2;RPL3L;RPS14;RPL7A;RPS17;RPS16;RPL13;RPS20;PABPC1;RPL15;RPS2;RPS27A;RPL17"]
["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957","24/106",1.0380648986979591e-09,6.351659598908138e-08,0,0,5.349404424276801,110.65728526826028,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPSA;SMG9;RPS3A;RPL10A;GSPT2;RPL3L;RPS14;RPL7A;RPS17;RPS16;RPL13;RPS20;PABPC1;RPL15;RPS2;RPS27A;RPL17"]
["Viral mRNA Translation Homo sapiens R-HSA-192823","21/84",1.6718502023890538e-09,9.627890283169903e-08,0,0,6.080837359098228,122.88967877293689,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPS3A;RPSA;RPL10A;RPL3L;RPL7A;RPS14;RPS17;RPS16;RPL13;RPS20;RPL15;RPS2;RPS27A;RPL17"]
["Selenoamino acid metabolism Homo sapiens R-HSA-2408522","24/111",2.7952524471673735e-09,1.5075309925126458e-07,0,0,5.040630847367014,99.27695555921156,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL10A;RPL3L;RPS14;RPL7A;RPS17;RPS16;QARS;CTH;RPL13;RPS20;RPL15;RPS2;RPS27A;RPL17;PSTK"]
["Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226","30/166",2.925749627961213e-09,1.5075309925126458e-07,0,0,4.043687650498796,79.45731031008862,"RPL4;RPL5;RPL3;NOL9;RPL10A;FBL;RPS14;RPL7A;EXOSC6;RPS17;RPS16;RPL13;RPL15;RPS2;RPS27A;RPL17;UTP15;WDR36;RPS8;KRR1;RPL22;RPS6;WDR75;RPL13A;RPSA;RPS3A;RPL3L;RPP21;RPS20;NOL11"]
["rRNA processing Homo sapiens R-HSA-72312","31/180",5.348998533503875e-09,2.6183347821501473e-07,0,0,3.8149942707480764,72.6617408634069,"RPL4;RPL5;RPL3;NOL9;THUMPD1;RPL10A;FBL;RPS14;RPL7A;EXOSC6;RPS17;RPS16;RPL13;RPL15;RPS2;RPS27A;RPL17;UTP15;WDR36;RPS8;KRR1;RPL22;RPS6;WDR75;RPL13A;RPSA;RPS3A;RPL3L;RPP21;RPS20;NOL11"]
["Influenza Life Cycle Homo sapiens R-HSA-168255","26/136",9.751809688861881e-09,4.5462008025694194e-07,0,0,4.322012356575463,79.72303154039801,"RPL4;RPL5;RPL3;RPL10A;NUP160;IPO5;RPS14;RPL7A;RPS17;RPS16;POLR2B;RPL13;POLR2G;RPL15;RPS2;RPS27A;RPL17;KPNA1;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL3L;RPS20"]
["Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273","25/128",1.1899190720420776e-08,5.295139870587245e-07,0,0,4.435556015933254,80.9346833112495,"RPL4;RPL5;RPL3;RPL10A;NUP160;IPO5;RPS14;RPL7A;RPS17;RPS16;POLR2B;RPL13;POLR2G;RPL15;RPS2;RPS27A;RPL17;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL3L;RPS20"]
["Influenza Infection Homo sapiens R-HSA-168254","27/147",1.2509759825869634e-08,5.324806465011466e-07,0,0,4.116034985422741,74.8984872446218,"RPL4;RPL5;RPL3;RPL10A;NUP160;IPO5;RPS14;RPL7A;RPS17;RPS16;POLR2B;RPL13;POLR2G;RPL15;RPS2;RPS27A;RPL17;KPNA1;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL3L;RPS20;SLC25A6"]
["SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339","21/107",1.5884066404385816e-07,6.479375420789047e-06,0,0,4.449140546006067,69.65291584765274,"RPL4;RPL5;RPL3;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;RPL10A;RPL3L;RPS14;RPL7A;RPS17;RPS16;RPL13;RPS20;RPL15;RPS2;RPS27A;RPL17"]
["Translation initiation complex formation Homo sapiens R-HSA-72649","15/57",1.705948938555743e-07,6.6804960433842895e-06,0,0,6.484836009331686,101.05951662515614,"RPS8;RPS6;RPS3A;RPSA;RPS14;RPS17;EIF3M;RPS16;EIF3L;RPS20;PABPC1;RPS2;RPS27A;EIF3D;EIF4B"]
["Activation of the mRNA upon binding of the cap-binding complex and eIFs and subsequent binding to 43S Homo sapiens R-HSA-72662","15/58",2.189535206485562e-07,8.244442181343713e-06,0,0,6.333690771396019,97.12338807336656,"RPS8;RPS6;RPS3A;RPSA;RPS14;RPS17;EIF3M;RPS16;EIF3L;RPS20;PABPC1;RPS2;RPS27A;EIF3D;EIF4B"]
["Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702","14/57",1.0961517562789793e-06,3.9745650718411887e-05,0,0,5.905771548453332,81.04906602794401,"RPS8;RPS6;RPS3A;RPSA;RPS14;RPS17;EIF3M;RPS16;EIF3L;RPS20;RPS2;RPS27A;EIF3D;EIF4B"]
["Formation of the ternary complex and subsequently the 43S complex Homo sapiens R-HSA-72695","13/50",1.3154050622680773e-06,4.5992198427158855e-05,0,0,6.369127516778524,86.24668621701258,"RPS8;RPS6;RPS3A;RPSA;RPS14;RPS17;EIF3M;RPS16;EIF3L;RPS20;RPS2;RPS27A;EIF3D"]
["Infectious disease Homo sapiens R-HSA-5663205","34/348",0.0004244797403365256,0.014329850544464092,0,0,1.9738367382552011,15.326144085631732,"RPL4;RPL5;RPL3;CCNT2;CCNT1;RPL10A;NUP160;IPO5;RPS14;RPL7A;RPS17;RPS16;POLR2B;RPL13;POLR2G;RPL15;RPS2;RPS27A;RPL17;KPNA1;TBP;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;EEF2;RPL3L;NMT2;RPS20;CD247;TAF4;SLC25A6"]
["Regulation of TP53 Activity through Association with Co-factors Homo sapiens R-HSA-6804759","5/14",0.0005452238728906292,0.01779247238533086,0,0,10.008986150755893,75.21066547607806,"PPP1R13B;PHF20;AKT2;AKT3;BANP"]
["rRNA modification in the nucleus Homo sapiens R-HSA-6790901","10/58",0.0008327860095612954,0.0262999194632422,0,0,3.7635436583811344,26.686286377111408,"UTP15;FBL;RPS14;WDR36;KRR1;RPS6;WDR75;THUMPD1;RPS2;NOL11"]
["Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291","32/335",0.0009044211097822267,0.0276696333274,0,0,1.9225453795379541,13.473612283404874,"RPL4;RPL5;LIPT1;RPL3;HDC;RPL10A;GLS;RPS14;RPL7A;RPS17;RPS16;CARNS1;RPL13;RPL15;RPS2;RPS27A;RPL17;PSTK;RPS8;RPL22;RPS6;BCKDHB;AMT;RPL13A;RPSA;RPS3A;RPL3L;ALDH6A1;QARS;TH;CTH;RPS20"]
["Regulation of TP53 Activity Homo sapiens R-HSA-5633007","17/151",0.0026187402190866195,0.07768929316623639,0,0,2.296769281599701,13.654435570387172,"PRKAB2;BRPF1;DYRK2;PPP1R13B;TBP;PHF20;SETD9;CSNK2A2;GATAD2B;AKT2;AKT3;JMY;SMYD2;RAD1;RPS27A;TAF4;BANP"]
["Clearance of Nuclear Envelope Membranes from Chromatin Homo sapiens R-HSA-2993913","3/7",0.004376088149414518,0.12600559700814157,0,0,13.49002849002849,73.272439693871,"LEMD3;EMD;LEMD2"]
["Signaling by ERBB2 Homo sapiens R-HSA-1227986","7/45",0.008775683002109784,0.2454683902590137,0,0,3.320004013847775,15.722777658496877,"YES1;AKT2;AKT3;MATK;PIK3R1;PLCG1;RPS27A"]
["Transcriptional Regulation by TP53 Homo sapiens R-HSA-3700989","29/348",0.010456874577533469,0.2843688947612573,0,0,1.6486677879082943,7.518742295746933,"CCNT2;DYRK2;PPP1R13B;CCNT1;PHF20;SETD9;GLS;POLR2B;AKT2;AKT3;SMYD2;COX11;POLR2G;RPS27A;BANP;PRKAB2;BRPF1;TBP;CSNK2A2;TSC1;FANCC;RABGGTB;GATAD2B;LRPPRC;TNFRSF10D;RBL2;JMY;RAD1;TAF4"]
["Regulation of TP53 Activity through Methylation Homo sapiens R-HSA-6804760","4/19",0.015855978868171812,0.3880750827985051,0,0,4.798225602027883,19.884847968424015,"SETD9;JMY;SMYD2;RPS27A"]
["Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Homo sapiens R-HSA-1236382","4/19",0.015855978868171812,0.3880750827985051,0,0,4.798225602027883,19.884847968424015,"PIK3R1;PLCG1;CBL;RPS27A"]
["Signaling by Ligand-Responsive EGFR Variants in Cancer Homo sapiens R-HSA-5637815","4/19",0.015855978868171812,0.3880750827985051,0,0,4.798225602027883,19.884847968424015,"PIK3R1;PLCG1;CBL;RPS27A"]
["Signaling by EGFR in Cancer Homo sapiens R-HSA-1643713","4/19",0.015855978868171812,0.3880750827985051,0,0,4.798225602027883,19.884847968424015,"PIK3R1;PLCG1;CBL;RPS27A"]
["PKB-mediated events Homo sapiens R-HSA-109703","6/40",0.017616013091686013,0.4206360199209903,0,0,3.1781512605042015,12.836384358786768,"PRKAB2;AKT2;PDE3B;RPS6;TSC1;EIF4B"]
["Disease Homo sapiens R-HSA-1643685","51/725",0.02269687260649843,0.5290532924229039,0,0,1.3755702201160371,5.2072597694013725,"RPL4;RPL5;SPON1;RPL3;CCNT2;CCNT1;RPL10A;IPO5;IKBKB;RPL7A;RPS14;RPS17;RPS16;AKT2;AKT3;KPNA1;CUBN;TBP;RPS8;RPL22;RPS6;RPL13A;RPSA;RPS3A;TGFBR2;KIT;SLC25A6;AMER1;TNKS;PIK3R1;CBL;ACACB;NUP160;POLR2B;RPL13;POLR2G;PLCG1;RPL15;RPS2;RPS27A;RPL17;SMAD4;EEF2;RPL3L;MIB1;APC;NEURL1;NMT2;RPS20;CD247;TAF4"]
["Initiation of Nuclear Envelope Reformation Homo sapiens R-HSA-2995383","3/13",0.028204724605345375,0.5874984125241091,0,0,5.394301994301994,19.24830319099963,"LEMD3;LEMD2;EMD"]
["Nuclear Envelope Reassembly Homo sapiens R-HSA-2995410","3/13",0.028204724605345375,0.5874984125241091,0,0,5.394301994301994,19.24830319099963,"LEMD3;LEMD2;EMD"]
["Downregulation of ERBB2:ERBB3 signaling Homo sapiens R-HSA-1358803","3/13",0.028204724605345375,0.5874984125241091,0,0,5.394301994301994,19.24830319099963,"AKT2;AKT3;RPS27A"]
["Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Homo sapiens R-HSA-112308","3/13",0.028204724605345375,0.5874984125241091,0,0,5.394301994301994,19.24830319099963,"CACNB3;CACNA2D3;CACNA2D2"]
["Signaling by Activin Homo sapiens R-HSA-1502540","3/13",0.028204724605345375,0.5874984125241091,0,0,5.394301994301994,19.24830319099963,"SMAD4;ACVR1C;ACVR2A"]
["Dopamine Neurotransmitter Release Cycle Homo sapiens R-HSA-212676","4/23",0.030670920585444898,0.6005366250630111,0,0,3.787272363418051,13.196524395172993,"BZRAP1;CASK;LIN7B;SLC18A2"]
["Regulation of TP53 Activity through Acetylation Homo sapiens R-HSA-6804758","4/23",0.030670920585444898,0.6005366250630111,0,0,3.787272363418051,13.196524395172993,"BRPF1;AKT2;AKT3;GATAD2B"]
["Signaling by BMP Homo sapiens R-HSA-201451","4/23",0.030670920585444898,0.6005366250630111,0,0,3.787272363418051,13.196524395172993,"SMAD4;SMAD5;ACVR2A;BMPR1A"]
["Depolymerisation of the Nuclear Lamina Homo sapiens R-HSA-4419969","3/15",0.04149783969607368,0.7386615465901115,0,0,4.494776828110162,14.302891860857475,"LEMD3;LEMD2;EMD"]
["Constitutive Signaling by NOTCH1 HD Domain Mutants Homo sapiens R-HSA-2691232","3/15",0.04149783969607368,0.7386615465901115,0,0,4.494776828110162,14.302891860857475,"NEURL1;RPS27A;MIB1"]
["Signaling by NOTCH1 HD Domain Mutants in Cancer Homo sapiens R-HSA-2691230","3/15",0.04149783969607368,0.7386615465901115,0,0,4.494776828110162,14.302891860857475,"NEURL1;RPS27A;MIB1"]
["Signaling by EGFRvIII in Cancer Homo sapiens R-HSA-5637812","3/15",0.04149783969607368,0.7386615465901115,0,0,4.494776828110162,14.302891860857475,"PIK3R1;PLCG1;CBL"]
["Constitutive Signaling by EGFRvIII Homo sapiens R-HSA-5637810","3/15",0.04149783969607368,0.7386615465901115,0,0,4.494776828110162,14.302891860857475,"PIK3R1;PLCG1;CBL"]
["Mitochondrial biogenesis Homo sapiens R-HSA-1592230","6/49",0.043169239158221774,0.7546908059981984,0,0,2.5117607973421925,7.893527535091717,"PRKAB2;POLG2;CHD9;TFAM;NRF1;POLRMT"]
["Phase 2 - plateau phase Homo sapiens R-HSA-5576893","4/26",0.04575068524914545,0.7634009994731129,0,0,3.270307639128932,10.087422553062007,"CACNB3;CACNA2D3;CACNA2D2;CACNA2D4"]
["Vitamin D (calciferol) metabolism Homo sapiens R-HSA-196791","2/7",0.04899396643032127,0.7634009994731129,0,0,7.187476280834915,21.677846217290988,"CUBN;CYP2R1"]
["NrCAM interactions Homo sapiens R-HSA-447038","2/7",0.04899396643032127,0.7634009994731129,0,0,7.187476280834915,21.677846217290988,"DLG1;NRCAM"]
["Loss of Function of SMAD2/3 in Cancer Homo sapiens R-HSA-3304349","2/7",0.04899396643032127,0.7634009994731129,0,0,7.187476280834915,21.677846217290988,"SMAD4;TGFBR2"]
["SMAD2/3 MH2 Domain Mutants in Cancer Homo sapiens R-HSA-3315487","2/7",0.04899396643032127,0.7634009994731129,0,0,7.187476280834915,21.677846217290988,"SMAD4;TGFBR2"]
["Histidine catabolism Homo sapiens R-HSA-70921","2/7",0.04899396643032127,0.7634009994731129,0,0,7.187476280834915,21.677846217290988,"HDC;CARNS1"]
["Regulation of KIT signaling Homo sapiens R-HSA-1433559","3/16",0.04912590701410226,0.7634009994731129,0,0,4.148805610344072,12.50188115766361,"YES1;KIT;CBL"]
["Phase 1 - inactivation of fast Na+ channels Homo sapiens R-HSA-5576894","4/27",0.05154522166428698,0.7884808126458899,0,0,3.1279550338898994,9.275311818356466,"CACNB3;CACNA2D3;CACNA2D2;CACNA2D4"]
["mTOR signalling Homo sapiens R-HSA-165159","5/39",0.052938166556250624,0.7973302316702977,0,0,2.6459394414283315,7.7754389133197614,"PRKAB2;AKT2;RPS6;TSC1;EIF4B"]
["Transcriptional activation of mitochondrial biogenesis Homo sapiens R-HSA-2151201","5/40",0.05798419313159493,0.8600988647853248,0,0,2.5702052467038197,7.3188774905304586,"POLG2;CHD9;TFAM;NRF1;POLRMT"]
[]
[]
[]
["Biocarta"]
[]
[]
["Term","Overlap","P-value","Adjusted P-value","Old P-value","Old Adjusted P-value","Odds Ratio","Combined Score","Genes"]
["Hemoglobin's Chaperone Homo sapiens h ahspPathway","1/13",0.0358050737240218,0.1153124525629414,0,0,30.2,100.5559032787779,"HBA2"]
["IL12 and Stat4 Dependent Signaling Pathway in Th1 Development Homo sapiens h IL12Pathway","1/15",0.041200627604441056,0.1153124525629414,0,0,25.883116883116884,82.54907099640234,"IL18R1"]
["Bone Remodeling Homo sapiens h ranklPathway","1/16",0.043887273641335565,0.1153124525629414,0,0,24.156363636363636,75.5159546794018,"IRF9"]
["Map Kinase Inactivation of SMRT Corepressor Homo sapiens h egfr smrtePathway","1/17",0.04656652576934638,0.1153124525629414,0,0,22.645454545454545,69.45074052559761,"MAP2K4"]
["TNFR1 Signaling Pathway Homo sapiens h tnfr1Pathway","1/17",0.04656652576934638,0.1153124525629414,0,0,22.645454545454545,69.45074052559761,"MAP2K4"]
["FAS signaling pathway ( CD95 ) Homo sapiens h fasPathway","1/20",0.054560117949919246,0.1153124525629414,0,0,19.066985645933013,55.45541451142644,"MAP2K4"]
["EGF Signaling Pathway Homo sapiens h egfPathway","1/20",0.054560117949919246,0.1153124525629414,0,0,19.066985645933013,55.45541451142644,"MAP2K4"]
["NF-kB Signaling Pathway Homo sapiens h nfkbPathway","1/21",0.05720999346183073,0.1153124525629414,0,0,18.112727272727273,51.82099606513529,"IL1R1"]
["Inhibition of Cellular Proliferation by Gleevec Homo sapiens h gleevecpathway","1/22",0.05985257433019706,0.1153124525629414,0,0,17.24935064935065,48.57194341390608,"MAP2K4"]