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["Table 1 Diagnostic criteria for vasospastic angina and microvascular angina"]
["Vasospastic angina diagnostic criteria elements"]
["(1)","Nitrate-responsive angina—during spontaneous episode, with at least 1 of the following:"]
[null,"a)  Rest angina—especially between night and early morning"]
[null,"b)  Marked diurnal variation in exercise tolerance—reduced in morning"]
[null,"c)  Hyperventilation can precipitate an episode"]
[null,"d)  Calcium channel blockers (but not b-blockers) suppress episodes"]
["(2)","Transient ischaemic ECG changes—during spontaneous episode, including any of the following in at least two contiguous leads:"]
[null,"a)  ST segment elevation ≥0.1 mV"]
[null,"b)  ST segment depression ≥0.1 mV"]
[null,"c)  New negative U waves"]
["(3)","Coronary artery spasm—defined as transient total or subtotal coronary artery occlusion (>90% constriction) with angina and ischaemic ECG changes either spontaneously or in response to a provocative stimulus (typically acetylcholine, ergonovine, or hyperventilation)"]
[]
["Definitive vasospastic angina is diagnosed if nitrate-responsive angina is evident during spontaneous episodes and either the transient ischaemic ECG changes during the spontaneous episodes or coronary artery spasm criteria are fulfilled."]
["Suspected vasospastic angina is diagnosed if nitrate-responsive angina is evident during spontaneous episodes but transient ischaemic ECG changes are equivocal or unavailable and coronary artery spasm criteria are equivocal."]
[]
["Microvascular angina diagnostic criteria elements"]
["1","Symptoms of myocardial ischemia:"]
[null,"a)  Effort or rest angina"]
[null,"b)  Exertional dyspnoea"]
["2","Absence of obstructive CAD (<50% diameter stenosis of FFR>0.80) by:"]
[null,"a)  Coronary CTA"]
[null,"b)  Invasive coronary angiography"]
["3","Objective evidence of myocardial ischemia:"]
[null,"a)  Ischemic ECG changes during an episode of chest pain"]
[null,"b)  Stress-induced chest pain and/or ischemic ECG changes in the presence or absence of transient/reversible abnormal myocardial perfusion and/or wall motion abnormality"]
["4","Evidence of impaired coronary microvascular function:"]
[null,"a)  Impaired coronary flow reserve (cut-off values depending on methodology use between ≤2.0 and ≤2.5)"]
[null,"b)  Coronary microvascular spasm, defined as reproduction of symptoms, ischemic ECG shifts but no epicardial spasm during acetylcholine testing."]
[null,"c)  Abnormal coronary microvascular resistance indices (e.g. IMR > 25)"]
[null,"d)  Coronary slow flow phenomenon, defined as TIMI frame count > 25."]
[]
["Definitive MVA is only diagnosed if all four criteria are present for a diagnosis of microvascular angina."]
["Suspected MVA is diagnosed if symptoms of ischemia are present (criteria-1) with no obstructive coronary artery disease (criteria-2) but only (a) objective evidence of myocardial ischemia (criteria-3), or (b) evidence of impaired coronary microvascular function (criteria-4) alone."]
["ECG electrocardiogram, CAD coronary artery disease, CTA computed tomographic angiography, FFR fractional flow reserve, IMR index of icrocirculatory resistance, TIMI thrombolysis in myocardial infarction."]