{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["rno"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"rno","index":0,"n_rows":51,"n_cols":7,"rows_kept":51,"merged":[[0,0,0,11]],"flags":["formulas_cached_only"]}
["Supplement Table 2: Significant pathway analysis between GSK-126+I/R group and I/R group"]
["PathwayID","Definition","Fisher-Pvalue","FDR","Enrichment_Score","GeneRatio","Genes"]
["rno05166","HTLV-I infection",0.0004581456,0.06523612,3.338996,0.059351,"ADCY4//ADCY7//ATF1//ATF4//BCL2L1//CALR//CANX//CDC16//CDC20//CDKN2A//CDKN2C//CREBBP//CREM//DVL1//FOSL1//FZD3//FZD6//IKBKB//IL15//MYC//NFATC1//NRAS//PDGFRA//PIK3R2//POLE2//POLE3//PPP3CA//PPP3R2//PRKACA//RT1-BA//RT1-CE1//RT1-CE11//RT1-CE12//RT1-CE14//RT1-CE5//RT1-CE7//RT1-DOA//RT1-M2//RT1-N3//RT1-T24-1//SMAD4//STAT5A//TGFB1//TGFB2//TGFBR2//TNF//TRRAP//TSPO//VAC14//WNT2B//WNT4//WNT6//WNT7A"]
["rno05030","Cocaine addiction",0.0004741363,0.06523612,3.324097,0.015677,"ATF4//ATF6B//BDNF//CREB3L1//DRD1//DRD2//FOSB//GNAI3//GRIN1//GRIN2A//GRIN2B//GRM2//PRKACA//SLC6A3"]
["rno04010","MAPK signaling pathway",0.0008641132000000001,0.06523612,3.063429,0.052632,"ATF4//BDNF//CACNA1C//CACNG5//CACNG6//DUSP2//DUSP4//ECSIT//FGF10//FGF19//FGFR1//GADD45A//HSPA1A//IKBKB//IL1B//LAMTOR3//MAP3K2//MAP4K1//MAP4K2//MAPK10//MAPK12//MAPK13//MAPK8IP2//MAPK8IP3//MYC//NF1//NFATC1//NRAS//NTRK2//PDGFRA//PPP3CA//PPP3R2//PRKACA//PRKCA//PTPN7//PTPRR//RAP1A//RPS6KA5//TAB1//TAOK1//TAOK2//TAOK3//TGFB1//TGFB2//TGFBR2//TNF//TRAF2"]
["rno05014","Amyotrophic lateral sclerosis (ALS)",0.0008815692000000001,0.06523612,3.054744,0.016797,"BCL2L1//CYCS//DERL1//GRIN1//GRIN2A//GRIN2B//MAPK12//MAPK13//NEFL//NEFM//PPP3CA//PPP3R2//SLC1A2//TNF//TOMM40L"]
["rno05031","Amphetamine addiction",0.002046399,0.102537,2.68901,0.017917,"ARC//ATF4//ATF6B//CACNA1C//CAMK2G//CREB3L1//DRD1//FOSB//GRIN1//GRIN2A//GRIN2B//PPP3CA//PPP3R2//PRKACA//PRKCA//SLC6A3"]
["rno04915","Estrogen signaling pathway",0.002078453,0.102537,2.68226,0.023516,"ADCY4//ADCY7//ATF4//ATF6B//CREB3L1//FKBP4//GABBR1//GABBR2//GNAI3//HBEGF//HSPA1A//KCNJ6//KCNJ9//MMP2//NRAS//PIK3R2//PRKACA//SHC1//SHC3//SHC4//SRC"]
["rno00604","Glycosphingolipid biosynthesis - ganglio series",0.004693741,0.161606,2.328481,0.006719,"HEXA//SLC33A1//ST3GAL1//ST3GAL2//ST6GALNAC6//ST8SIA1"]
["rno04940","Type I diabetes mellitus",0.005255751,0.161606,2.279365,0.019037,"HSPD1//ICA1//IFNG//IL12B//IL1B//RT1-BA//RT1-CE1//RT1-CE11//RT1-CE12//RT1-CE14//RT1-CE5//RT1-CE7//RT1-DOA//RT1-M2//RT1-N3//RT1-T24-1//TNF"]
["rno04727","GABAergic synapse",0.005628295,0.161606,2.249623,0.021277,"ADCY4//ADCY7//CACNA1C//GABARAP//GABARAPL1//GABBR1//GABBR2//GABRG2//GABRQ//GNAI3//GNG2//GNGT2//GPHN//HAP1//KCNJ6//PRKACA//PRKCA//SLC32A1//SRC"]
["rno04728","Dopaminergic synapse",0.00566863,0.161606,2.246522,0.027996,"ATF4//ATF6B//CACNA1C//CAMK2G//CREB3L1//DRD1//DRD2//DRD5//GNAI3//GNG2//GNGT2//GRIN2A//GRIN2B//KCNJ6//KCNJ9//MAPK10//MAPK12//MAPK13//PPP2R3A//PPP2R5A//PPP3CA//PRKACA//PRKCA//SCN1A//SLC6A3"]
["rno05169","Epstein-Barr virus infection",0.006005629,0.161606,2.221442,0.043673,"AKAP8L//CREBBP//CSNK2A2//DDX58//EIF2AK4//GTF2E2//HSPA1A//IFNG//IKBKB//LYN//MAPK10//MAPK12//MAPK13//MYC//NCOR2//NUP214//PIK3R2//POLR2C//POLR2J//POLR3B//POLR3D//POLR3F//POLR3GL//PRKACA//PSMC1//PSMD4//RT1-CE1//RT1-CE11//RT1-CE12//RT1-CE14//RT1-CE5//RT1-CE7//RT1-M2//RT1-N3//RT1-T24-1//SPN//TAB1//TRAF2//USP7"]
["rno05206","MicroRNAs in cancer",0.006649342,0.1640171,2.177221,0.030235,"ABCB1A//ABCC1//BCL2L11//CCNG1//CDC25A//CDKN2A//CREBBP//DNMT1//EZH2//FZD3//HOXD10//IKBKB//MCL1//MDM4//MYC//NOTCH1//NOTCH4//NRAS//PDGFRA//PRKCA//RPS6KA5//RPTOR//SHC1//SHC4//SPRY2//TGFB2//ZEB2"]
["rno04932","Non-alcoholic fatty liver disease (NAFLD)",0.008996469,0.20111810000000002,2.045928,0.032475,"ADIPOQ//ADIPOR1//ATF4//BCL2L11//COX5A//COX6A2//CYCS//IKBKB//IL1B//IL6R//INSR//LEPR//MAPK10//NDUFA12//NDUFA4//NDUFA4L2//NDUFA5//NDUFS8//NR1H3//PIK3R2//PRKAA1//PRKAG3//SDHD//SREBF1//TGFB1//TNF//TRAF2//UQCRC2//UQCRFS1"]
["rno04612","Antigen processing and presentation",0.01027245,0.20111810000000002,1.988326,0.021277,"CALR//CANX//HSPA1A//IFNG//PSME2//PSME3//RT1-BA//RT1-CE1//RT1-CE11//RT1-CE12//RT1-CE14//RT1-CE5//RT1-CE7//RT1-DOA//RT1-M2//RT1-N3//RT1-T24-1//TAPBP//TNF"]
["rno00260","Glycine, serine and threonine metabolism",0.01130875,0.20111810000000002,1.946585,0.011198,"AGXT//ALAS1//AOC3//DLD//DMGDH//GCSH//GRHPR//PSAT1//SARDH//SDS"]
["rno04925","Aldosterone synthesis and secretion",0.01148633,0.20111810000000002,1.939819,0.019037,"ADCY4//ADCY7//AGTR1B//ATF1//ATF4//ATF6B//CACNA1C//CAMK1//CAMK1G//CAMK2G//CREB3L1//CYP11A1//DAGLB//MC2R//PDE2A//PRKACA//PRKCA"]
["rno03013","RNA transport",0.01257787,0.20111810000000002,1.900393,0.032475,"EIF1B//EIF2B1//EIF2B5//EIF3B//EIF3C//EIF3D//EIF3I//EIF4A1//EIF4A3//EIF4E2//EIF4EBP2//EIF5B//NDC1//NMD3//NUP153//NUP210//NUP214//NUP35//NUP54//NUP85//PABPC1//POP7//RANGAP1//RPP21//RPP25L//SNUPN//STRAP//THOC2//XPO5"]
["rno05330","Allograft rejection",0.01262864,0.20111810000000002,1.8986429999999999,0.016797,"IFNG//IL12B//IL5//RT1-BA//RT1-CE1//RT1-CE11//RT1-CE12//RT1-CE14//RT1-CE5//RT1-CE7//RT1-DOA//RT1-M2//RT1-N3//RT1-T24-1//TNF"]
["rno04720","Long-term potentiation",0.01312088,0.20111810000000002,1.882037,0.015677,"ATF4//CACNA1C//CAMK2G//CREBBP//GRIN1//GRIN2A//GRIN2B//NRAS//PPP1R1A//PPP3CA//PPP3R2//PRKACA//PRKCA//RAP1A"]
["rno04514","Cell adhesion molecules (CAMs)",0.01358906,0.20111810000000002,1.866811,0.033595,"ALCAM//CADM1//CD2//CD99//CDH1//CLDN6//GLYCAM1//LRRC4//LRRC4B//MADCAM1//MPZ//NFASC//NLGN1//NRXN3//NTNG2//PDCD1//PECAM1//RT1-BA//RT1-CE1//RT1-CE11//RT1-CE12//RT1-CE14//RT1-CE5//RT1-CE7//RT1-DOA//RT1-M2//RT1-N3//RT1-T24-1//SDC1//SPN"]
["rno04080","Neuroactive ligand-receptor interaction",0.01454624,0.2050327,1.837249,0.051512,"ADORA2B//AGTR1B//BDKRB1//CHRM1//CHRM4//CHRNA10//CHRNA4//CHRNA9//CHRNB4//CRHR1//DRD1//DRD2//DRD5//F2RL1//F2RL2//GABBR1//GABBR2//GABRG2//GABRQ//GRIN1//GRIN2A//GRIN2B//GRM2//GRM7//GRM8//HCRTR1//HCRTR2//HTR1A//HTR5B//LEPR//LHCGR//LPAR2//MAS1//MC2R//NTSR2//OPRD1//P2RX4//P2RX6//P2RY2//PTGER4//PTGIR//TAAR7C//THRA//TRPV1//TSPO//UTS2R"]
["rno03050","Proteasome",0.01620495,0.2152051,1.790352,0.012318,"IFNG//POMP//PSMA1//PSMA3//PSMA3L//PSMB2//PSMC1//PSMD4//PSME2//PSME3//PSME4"]
["rno04750","Inflammatory mediator regulation of TRP channels",0.01672202,0.2152051,1.7767110000000002,0.023516,"ADCY4//ADCY7//ASIC2//BDKRB1//CAMK2G//CYP2J10//F2RL1//IL1B//IL1RAP//MAPK10//MAPK12//MAPK13//P2RY2//PIK3R2//PRKACA//PRKCA//PRKCQ//PTGER4//SRC//TRPV1//TRPV2"]
["rno04211","Longevity regulating pathway - mammal",0.018871779999999998,0.2213565,1.7241870000000001,0.020157,"ADCY4//ADCY7//ADIPOQ//ADIPOR1//ATF4//ATF6B//ATG13//CREB3L1//EIF4E2//IGF1R//INSR//NRAS//PIK3R2//PRKAA1//PRKACA//PRKAG3//RHEB//RPTOR"]
["rno05332","Graft-versus-host disease",0.01936858,0.2213565,1.7129020000000001,0.015677,"IFNG//IL1B//RT1-BA//RT1-CE1//RT1-CE11//RT1-CE12//RT1-CE14//RT1-CE5//RT1-CE7//RT1-DOA//RT1-M2//RT1-N3//RT1-T24-1//TNF"]
["rno04310","Wnt signaling pathway",0.02055569,0.2213565,1.687068,0.027996,"BTRC//CAMK2G//CREBBP//CSNK2A2//CTBP2//DVL1//FOSL1//FZD3//FZD6//MAPK10//MYC//NFATC1//NKD2//PPP3CA//PPP3R2//PRICKLE2//PRKACA//PRKCA//SFRP1//SMAD4//TCF7L2//WNT2B//WNT4//WNT6//WNT7A"]
["rno04520","Adherens junction",0.02063629,0.2213565,1.685368,0.016797,"ACTN3//CDH1//CREBBP//CSNK2A2//CTNNA1//CTNNA2//FGFR1//IGF1R//INSR//PTPRB//SMAD4//SNAI1//SRC//TCF7L2//TGFBR2"]
["rno03010","Ribosome",0.02179506,0.2213565,1.661642,0.031355,"MRPL10//MRPL14//MRPL17//MRPL18//MRPL19//MRPL36//MRPL9//MRPS10//MRPS7//RPL14//RPL18//RPL18A//RPL19//RPL27A//RPL29//RPL30//RPL31//RPL4//RPL41//RPL9//RPLP0//RPLP1//RPS15A//RPS16//RPS23//RPS27L//RPS3A//RPS5"]
["rno04668","TNF signaling pathway",0.02181109,0.2213565,1.6613229999999999,0.022396,"ATF4//ATF6B//BAG4//CCL12//CREB3L1//CSF1//CXCL2//IKBKB//IL15//IL18R1//IL1B//LIF//MAPK10//MAPK12//MAPK13//PIK3R2//RPS6KA5//TAB1//TNF//TRAF2"]
["rno04723","Retrograde endocannabinoid signaling",0.023581770000000002,0.2213565,1.627424,0.021277,"ABHD6//ADCY4//ADCY7//CACNA1C//DAGLB//GABRG2//GABRQ//GNAI3//GNG2//GNGT2//KCNJ6//KCNJ9//MAPK10//MAPK12//MAPK13//MGLL//PRKACA//PRKCA//SLC32A1"]
["rno04933","AGE-RAGE signaling pathway in diabetic complications",0.023581770000000002,0.2213565,1.627424,0.021277,"AGTR1B//CCL12//IL1B//MAPK10//MAPK12//MAPK13//MMP2//NFATC1//NRAS//PIK3R2//PRKCA//PRKCZ//SMAD4//STAT5A//TGFB1//TGFB2//TGFBR2//THBD//TNF"]
["rno05220","Chronic myeloid leukemia",0.02585522,0.2213565,1.5874519999999999,0.016797,"BCL2L1//CDKN2A//CTBP2//IKBKB//MYC//NRAS//PIK3R2//SHC1//SHC3//SHC4//SMAD4//STAT5A//TGFB1//TGFB2//TGFBR2"]
["rno04261","Adrenergic signaling in cardiomyocytes",0.026053720000000002,0.2213565,1.58413,0.027996,"ADCY4//ADCY7//AGTR1B//ATF4//ATF6B//ATP1B3//CACNA1C//CACNG5//CACNG6//CAMK2G//CREB3L1//CREM//GNAI3//MAPK12//MAPK13//PIK3R2//PLN//PPP1R1A//PPP2R3A//PPP2R5A//PRKACA//PRKCA//RAPGEF4//RPS6KA5//TPM3"]
["rno04725","Cholinergic synapse",0.02617392,0.2213565,1.582131,0.022396,"ADCY4//ADCY7//ATF4//CACNA1C//CAMK2G//CHRM1//CHRM4//CHRNA4//CHRNB4//CREB3L1//GNAI3//GNG2//GNGT2//KCNJ4//KCNJ6//KCNQ3//NRAS//PIK3R2//PRKACA//PRKCA"]
["rno04931","Insulin resistance",0.02617392,0.2213565,1.582131,0.022396,"CPT1B//CREB3L1//GYS2//IKBKB//INSR//MAPK10//NR1H2//NR1H3//OGT//PIK3R2//PPP1R3D//PRKAA1//PRKAG3//PRKCQ//PRKCZ//SLC27A1//SLC27A5//SLC2A4//SREBF1//TNF"]
["rno04916","Melanogenesis",0.02803477,0.23050810000000002,1.552303,0.020157,"ADCY4//ADCY7//CAMK2G//CREB3L1//CREBBP//DVL1//FZD3//FZD6//GNAI3//MITF//NRAS//PRKACA//PRKCA//TCF7L2//WNT2B//WNT4//WNT6//WNT7A"]
["rno04213","Longevity regulating pathway - multiple species",0.02945734,0.2356587,1.530807,0.014558,"ADCY4//ADCY7//CLPB//EIF4EBP2//HSPA1A//IGF1R//INSR//NRAS//PIK3R2//PRKAA1//PRKACA//PRKAG3//RPTOR"]
["rno00240","Pyrimidine metabolism",0.031044099999999998,0.2365906,1.5080209999999998,0.021277,"CAD//DUT//ENTPD4//NME7//NT5C//NT5C1B//NT5E//POLA2//POLE2//POLE3//POLR1E//POLR2C//POLR2J//POLR3B//POLR3D//POLR3F//POLR3GL//TXNRD1//UPB1"]
["rno04919","Thyroid hormone signaling pathway",0.031172409999999998,0.2365906,1.50623,0.023516,"ATP1B3//CREBBP//GATA4//HDAC3//MED12//MED14//MED17//MYC//NOTCH1//NOTCH4//NRAS//PIK3R2//PLN//PRKACA//PRKCA//RCAN2//RHEB//RXRG//SRC//THRA//WNT4"]
["rno04330","Notch signaling pathway",0.033015539999999996,0.2395093,1.481282,0.012318,"CREBBP//CTBP2//DTX3//DVL1//HES5//JAG2//LFNG//NCOR2//NOTCH1//NOTCH4//PSENEN"]
["rno04060","Cytokine-cytokine receptor interaction",0.03317527,0.2395093,1.479185,0.038074,"ACVR1B//CCL12//CCR1//CCR7//CD70//CSF1//CSF3//CXCL14//CXCL2//CXCR3//CXCR5//CXCR6//EPO//IFNG//IL11RA1//IL12B//IL15//IL18R1//IL1B//IL1RAP//IL22//IL3RA//IL5//IL6R//IL9R//LEPR//LIF//NGFR//PDGFRA//TGFB1//TGFB2//TGFBR2//TNF//TNFRSF11B"]
["rno04152","AMPK signaling pathway",0.03636807,0.2536391,1.4392800000000001,0.024636,"ADIPOQ//ADIPOR1//CPT1B//CREB3L1//GYS2//HNF4A//IGF1R//INSR//LEPR//MLYCD//PFKFB4//PFKL//PIK3R2//PPP2R3A//PPP2R5A//PRKAA1//PRKAG3//RHEB//RPTOR//SCD//SLC2A4//SREBF1"]
["rno04724","Glutamatergic synapse",0.03684622,0.2536391,1.433607,0.022396,"ADCY4//ADCY7//CACNA1C//GNAI3//GNG2//GNGT2//GRIN1//GRIN2A//GRIN2B//GRM2//GRM7//GRM8//PLD1//PPP3CA//PPP3R2//PRKACA//PRKCA//SHANK2//SLC1A2//SLC1A3"]
["rno04210","Apoptosis",0.03914497,0.26082530000000004,1.407324,0.016797,"BCL2L1//CYCS//DFFA//IKBKB//IL1B//IL1RAP//IL3RA//IRAK2//PIK3R2//PPP3CA//PPP3R2//PRKACA//PRKAR1A//TNF//TRAF2"]
["rno04071","Sphingolipid signaling pathway",0.03965249,0.26082530000000004,1.40173,0.023516,"ABCC1//ACER1//ASAH1//CERS4//GNAI3//MAPK10//MAPK12//MAPK13//NRAS//OPRD1//PIK3R2//PLD1//PPP2R3A//PPP2R5A//PRKCA//PRKCZ//SGMS1//SPHK1//SPHK2//TNF//TRAF2"]
["rno04141","Protein processing in endoplasmic reticulum",0.04151188,0.2671199,1.381828,0.030235,"ATF4//ATF6B//BAG1//CALR//CANX//DERL1//DNAJA2//DNAJB11//EDEM1//EIF2AK4//FBXO6//GANAB//HSPA1A//HSPA4L//MAN1A1//MAN1A2//MAPK10//MBTPS1//PRKCSH//RPN2//SEC24D//SEC31A//STUB1//TRAF2//UBE2D4//UBQLN1//UBQLN4"]
["rno04912","GnRH signaling pathway",0.047652270000000004,0.2988813,1.3219159999999999,0.017917,"ADCY4//ADCY7//ATF4//CACNA1C//CAMK2G//HBEGF//MAP3K2//MAPK10//MAPK12//MAPK13//MMP2//NRAS//PLD1//PRKACA//PRKCA//SRC"]
["rno04380","Osteoclast differentiation",0.048925,0.2988813,1.3104689999999999,0.024636,"CSF1//FOSB//FOSL1//IFNG//IKBKB//IL1B//MAPK10//MAPK12//MAPK13//MITF//NFATC1//OSCAR//PIK3R2//PPP3CA//PPP3R2//TAB1//TGFB1//TGFB2//TGFBR2//TNF//TNFRSF11B//TRAF2"]
["rno05321","Inflammatory bowel disease (IBD)",0.04947697,0.2988813,1.3055970000000001,0.013438,"IFNG//IL12B//IL18R1//IL1B//IL22//IL5//NFATC1//RT1-BA//RT1-DOA//TGFB1//TGFB2//TNF"]