{"text_format":"3","workbook":"xlsx","n_sheets":1,"sheets":["Table 1"],"read":"whole","date_system":"1900"}

{"sheet":"Table 1","index":0,"n_rows":34,"n_cols":23,"rows_kept":34,"merged":[[0,0,0,21],[2,2,2,7],[2,9,2,14],[2,16,2,21],[2,22,4,22],[6,2,6,7],[6,9,6,14],[6,16,6,21],[7,2,7,7],[7,9,7,14],[7,16,7,21]]}
["Table 1. Association between plasma concentration of angiopoietin-1, -2 and kenvatinib and clinical response after lenvatinib therapy "]
[]
["Best response",null,"Partial response",{"$nulls":6},"Stable disease",{"$nulls":6},"Progressive disease",{"$nulls":5},"P-values"]
["Number",{"$nulls":3},23,{"$nulls":6},8,{"$nulls":6},5]
[null,null,"Median","(","Q1","-","Q3",")",null,"Median","(","Q1","-","Q3",")",null,"Median","(","Q1","-","Q3",")"]
["Age",null,68,"(",61,"-",71,")",null,62.5,"(",51.8,"-",75.8,")",null,71,"(",58,"-",75.5,")",0.733]
["Female : Male",null,"14 : 9",{"$nulls":6},"5 : 3",{"$nulls":6},"4 : 1",{"$nulls":5},0.747]
["PTC/FTC/MTC/PDTC/ATC",null,"9/4/1/4/5",{"$nulls":6},"3/3/0/0/2",{"$nulls":6},"1/1/0/0/3",{"$nulls":5},0.708]
["Angiopoietin-1"]
[" Before lenvatinib therapy (baseline) (pg/mL)",null,6667,"(",4833,"-",8083,")",null,6083,"(",4653,"-",8146,")",null,6833,"(",5334,"-",8500,")",0.739]
[" 1 month after lenvatinib treatment (pg/mL)",null,5417,"(",3833,"-",6333,")","**",6250,"(",5349,"-",7145,")",null,5750,"(",3792,"-",6500,")",0.395]
[" 1 year after lenvatinib treatment (pg/mL)",null,5542,"(",4490,"-",7188,")",null,7250,"(",4792,"-",8395,")",{"$nulls":7},0.442]
[" Change on 1 month from baseline (%)",null,"-16.7","(","-29.3","-",1.6,")",null,"-2.9","(","-19.3","-",33.5,")",null,"-28.0","(","-40.2","-",4.6,")",0.192]
[" Change on 1 year from baseline (%)",null,4.1,"(","-18.1","-",20.4,")",null,{"v":2,"d":"2.0"},"(","-15.2","-",{"v":31,"d":"31.0"},")",{"$nulls":7},0.878]
["Angiopoietin-2"]
[" Before lenvatinib therapy (baseline) (pg/mL)",null,1773,"(",1343,"-",2918,")",null,1570,"(",1472,"-",1928,")",null,2136,"(",1080,"-",2887,")",{"v":0.77,"d":"0.770"}]
[" 1 month after lenvatinib treatment (pg/mL)",null,1005,"(",651,"-",1517,")","***",893,"(",790,"-",1007,")","*",936,"(",780,"-",11408,")",0.632]
[" 1 year after lenvatinib treatment (pg/mL)",null,1046,"(",851,"-",1460,")","**",1015,"(",936,"-",1387,")",{"$nulls":7},0.878]
[" Change on 1 month from baseline (%)",null,"-51.8","(","-60.5","-","-40.7",")",null,"-39.8","(","-62.4","-","-31.9",")",null,"-12.1","(","-49.2","-",313,")",0.081]
[" Change on 1 year from baseline (%)",null,"-40.2","(","-59.3","-","-29.1",")",null,"-36.9","(","-47.3","-","-11.6",")",{"$nulls":7},0.442]
["Angiopoietin-2/angiopoietin-1 ratio"]
[" Before lenvatinib therapy (baseline)",null,0.31,"(",{"v":0.2,"d":"0.20"},"-",0.51,")",null,0.25,"(",0.21,"-",0.32,")",null,0.33,"(",0.13,"-",0.53,")",0.625]
[" 1 month after lenvatinib treatment",null,0.17,"(",0.13,"-",0.35,")","***",0.15,"(",0.13,"-",{"v":0.2,"d":"0.20"},")","*",0.16,"(",0.12,"-",3.31,")",0.625]
[" 1 year after lenvatinib treatment",null,{"v":0.2,"d":"0.20"},"(",0.14,"-",0.28,")","**",0.17,"(",0.13,"-",0.21,")",{"$nulls":7},0.442]
["Lenvatinib"]
[" C0 on 1 month after lenvatinib treatment (ng/mL)",null,71.2,"(",64.4,"-",164,")",null,130,"(",58.8,"-",209,")",null,108,"(",{"v":54,"d":"54.0"},"-",144,")",0.598]
[" C0 on 1 year after lenvatinib treatment (ng/mL)",null,49.7,"(",{"v":37,"d":"37.0"},"-",113,")","##",77.2,"(",30.7,"-",138,")",{"$nulls":7},0.721]
[" Daily dose on 1 month after lenvatinib treatment (mg)",null,{"v":20,"d":"20.0"},"(",{"v":20,"d":"20.0"},"-",{"v":24,"d":"24.0"},")",null,{"v":24,"d":"24.0"},"(",16.5,"-",{"v":24,"d":"24.0"},")",null,{"v":14,"d":"14.0"},"(",{"v":12,"d":"12.0"},"-",{"v":22,"d":"22.0"},")",0.119]
[" Daily dose on 1 year after lenvatinib treatment (mg)",null,{"v":10,"d":"10.0"},"(",9.5,"-",14.5,")","##",{"v":11,"d":"11.0"},"(",{"v":8,"d":"8.0"},"-",{"v":14,"d":"14.0"},")",{"$nulls":7},0.721]
[]
["Q: quartile"]
["PTC: papillary thyroid cancer, FTC: follicular thyroid cancer, MTC: medullary thyroid cancer, PDTC: poorly differentiated thyroid cancer, ATC: anaplastic thyroid cancer "]
["* P< 0.05, ** P<0.01, *** P<0.001 vs baseline"]
["## P<0.01 vs 1 month after lenvatinib therapy"]