{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["rno"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"rno","index":0,"n_rows":48,"n_cols":12,"rows_kept":48,"merged":[[0,0,0,10],[1,0,1,10],[2,0,2,10],[3,0,3,10],[4,0,4,10],[5,0,5,10],[6,0,6,10],[7,0,7,10],[8,0,8,10],[9,0,9,10],[10,0,10,10],[11,0,11,10],[12,0,12,10]],"flags":["formulas_cached_only"]}
["#Column \"PathwayID\" stands for Pathway identifiers used in KEGG"]
["#Column \"Definition\" stands for the definition of the PathwayID"]
["#Column \"OriginalWebSite\"stands for The map's website,the nodes with red frame and red symbol are associated with the DE genes, green nodes have no significance"]
["#Column \"p-value\" "]
["        \"Fisher-Pvalue\" stands for the enrichment p-value of the PathwayID used Fisher's exact test"]
["#Column \"SelectionCounts\" stands for the Count of the DE genes' entities directly associated with the listed PathwayID"]
["#Column \"SelectionSize\" stands for the total number of the DE genes' entities"]
["#Column \"Count\" stands for the count of the chosen background population genes' entities associated with the listed PathwayID"]
["#Column \"Size\" stands for the total number of chosen background population genes' entities"]
["#Column \"FDR\" stands for the false discovery rate of the PathwayID"]
["#Column \"Enrichment_Score\" stands for the Enrichment Score value of the PathwayID, it equals \"-log10(Pvalue)\""]
["#Column \"GeneRatio\" stands for the Gene Ratio value of the PathwayID, it equals \"SelectionCounts/SelectionSize\""]
["#Column \"GENES\" stands for the DE genes associated with the PathwayID"]
[]
["PathwayID","Definition","OriginalWebSite","Fisher-Pvalue","SelectionCounts","SelectionSize","Count","Size","FDR","Enrichment_Score","GeneRatio","Genes"]
["rno05133","Pertussis - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno05133+50663+29271+25686+25643+25325+24493+292060+116590+287362",0.001209362,9,314,74,8790,0.1465322,2.917444,0.028662,"CALM2//CFL1//GNAI1//GNAI3//IL10//IL1A//IRF8//MAPK1//NLRP3"]
["rno05030","Cocaine addiction - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno05030+24225+25686+25643+24412+24415+25750+29190",0.001276616,7,314,47,8790,0.1465322,2.8939399999999997,0.022293,"BDNF//GNAI1//GNAI3//GRIN2D//GRM2//MAOB//PDYN"]
["rno04971","Gastric acid secretion - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04971+25650+50663+171140+25706+25686+25643+170847+84020+25031",0.001332111,9,314,75,8790,0.1465322,2.87546,0.028662,"ATP1B1//CALM2//CAMK2G//CCKBR//GNAI1//GNAI3//KCNJ15//KCNQ1//PLCB4"]
["rno04966","Collecting duct acid secretion - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04966+296981+312488+289407+79430+293650",0.0023797420000000002,5,314,27,8790,0.19632870000000002,2.62347,0.015924,"ATP6V0A4//ATP6V1B1//ATP6V1G3//CLCNKB//TCIRG1"]
["rno04672","Intestinal immune network for IgA production - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04672+114492+24772+25325+297604+25046+294270",0.006190093,6,314,47,8790,0.3833965,2.208303,0.019108,"CCL28//CXCL12//IL10//LTBR//PIGR//RT1-DB1"]
["rno04261","Adrenergic signaling in cardiomyocytes - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04261+25650+29693+50663+171140+25620+25686+25643+84020+116590+25031+25594+24852",0.00699176,12,314,149,8790,0.3833965,2.155413,0.038217,"ATP1B1//ATP2A2//CALM2//CAMK2G//CREM//GNAI1//GNAI3//KCNQ1//MAPK1//PLCB4//PPP1CB//TPM4"]
["rno04724","Glutamatergic synapse - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04724+25686+25643+114120+24412+24415+116590+691810+25031+29642+252919",0.008421168,10,314,116,8790,0.3833965,2.074628,0.031847,"GNAI1//GNAI3//GNG12//GRIN2D//GRM2//MAPK1//PLA2G4C//PLCB4//SLC38A2//SLC38A3"]
["rno04713","Circadian entrainment - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04713+50663+171140+25686+25643+114120+24412+116590+25031+25523",0.00929446,9,314,100,8790,0.3833965,2.031776,0.028662,"CALM2//CAMK2G//GNAI1//GNAI3//GNG12//GRIN2D//MAPK1//PLCB4//PRKG2"]
["rno04371","Apelin signaling pathway - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04371+50663+64032+58974+25686+25643+114120+116590+499497+25482+25031+50554",0.0120463,11,314,141,8790,0.4416976,1.919146,0.035032,"CALM2//CTGF//GABARAP//GNAI1//GNAI3//GNG12//MAPK1//MEF2C//MRAS//PLCB4//SMAD4"]
["rno04924","Renin secretion - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04924+50663+24323+25686+25643+83731+25031+25523",0.01403107,7,314,72,8790,0.4449344,1.852909,0.022293,"CALM2//EDN1//GNAI1//GNAI3//KCNMA1//PLCB4//PRKG2"]
["rno04060","Cytokine-cytokine receptor interaction - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04060+245921+114492+81780+287673+500318+24772+246097+290921+25325+24493+24500+24536+297604+366455+29152+302965+364031",0.01553438,17,314,268,8790,0.4449344,1.808706,0.05414,"ACVR1C//CCL28//CCL5//CCR7//CD27//CXCL12//FAS//GDF2//IL10//IL1A//IL9R//LEPR//LTBR//MPL//MSTN//TNFRSF12A//TNFSF18"]
["rno04727","GABAergic synapse - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04727+58974+81657+24379+25686+25643+114120+29642+252919",0.016776140000000002,8,314,92,8790,0.4449344,1.7753079999999999,0.025478,"GABARAP//GABBR1//GAD1//GNAI1//GNAI3//GNG12//SLC38A2//SLC38A3"]
["rno00120","Primary bile acid biosynthesis - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno00120+25429+81924+25541",0.01789536,3,314,16,8790,0.4449344,1.74726,0.009554,"CYP7B1//CYP8B1//SCP2"]
["rno05323","Rheumatoid arthritis - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno05323+296981+312488+289407+81780+24772+24493+294270+293650",0.01888049,8,314,94,8790,0.4449344,1.7239870000000002,0.025478,"ATP6V0A4//ATP6V1B1//ATP6V1G3//CCL5//CXCL12//IL1A//RT1-DB1//TCIRG1"]
["rno04022","cGMP-PKG signaling pathway - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04022+25650+29693+50663+25686+25643+83731+116590+499497+25031+25594+25523+85333",0.02022429,12,314,172,8790,0.4449344,1.694127,0.038217,"ATP1B1//ATP2A2//CALM2//GNAI1//GNAI3//KCNMA1//MAPK1//MEF2C//PLCB4//PPP1CB//PRKG2//SLC25A4"]
["rno04730","Long-term depression - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04730+25686+25643+116590+691810+25031+25523",0.02275062,6,314,62,8790,0.4692316,1.6430069999999999,0.019108,"GNAI1//GNAI3//MAPK1//PLA2G4C//PLCB4//PRKG2"]
["rno04910","Insulin signaling pathway - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04910+50663+363275+25623+116590+25594+24679+25739+287871+85385+25139",0.02581668,10,314,138,8790,0.4857534,1.5880999999999998,0.031847,"CALM2//EIF4E2//GYS2//MAPK1//PPP1CB//PRKAR2B//PYGB//RPTOR//SHC1//SLC2A4"]
["rno04217","Necroptosis - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04217+171140+246097+24399+24493+287362+691810+25739+85333+367264+683206+360834",0.02811256,11,314,160,8790,0.4857534,1.5511,0.035032,"CAMK2G//FAS//GLUD1//IL1A//NLRP3//PLA2G4C//PYGB//SLC25A4//STAT4//TNFAIP3//VPS4B"]
["rno04720","Long-term potentiation - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04720+50663+171140+24412+116590+25031+25594",0.029904319999999998,6,314,66,8790,0.4857534,1.524266,0.019108,"CALM2//CAMK2G//GRIN2D//MAPK1//PLCB4//PPP1CB"]
["rno05031","Amphetamine addiction - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno05031+50663+171140+24412+25750+29190+25594",0.029904319999999998,6,314,66,8790,0.4857534,1.524266,0.019108,"CALM2//CAMK2G//GRIN2D//MAOB//PDYN//PPP1CB"]
["rno05152","Tuberculosis - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno05152+296981+50663+171140+25325+24493+29469+116590+295631+362491+294270+25155+293650",0.030911579999999998,12,314,183,8790,0.4857534,1.509879,0.038217,"ATP6V0A4//CALM2//CAMK2G//IL10//IL1A//LBP//MAPK1//PLA2R1//RIPK2//RT1-DB1//SYK//TCIRG1"]
["rno04726","Serotonergic synapse - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04726+25686+25643+114120+54262+25750+116590+691810+25031+25553",0.03626227,9,314,126,8790,0.4884762,1.440545,0.028662,"GNAI1//GNAI3//GNG12//KCNN2//MAOB//MAPK1//PLA2G4C//PLCB4//SLC6A4"]
["rno00250","Alanine, aspartate and glutamate metabolism - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno00250+291133+24379+297417+24399",0.03832282,4,314,36,8790,0.4884762,1.4165429999999999,0.012739,"ALDH5A1//GAD1//GFPT1//GLUD1"]
["rno04964","Proximal tubule bicarbonate reclamation - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04964+25650+24399+252919",0.04206929,3,314,22,8790,0.4884762,1.376035,0.009554,"ATP1B1//GLUD1//SLC38A3"]
["rno04072","Phospholipase D signaling pathway - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04072+79121+100361138+24415+116590+25482+66018+691810+25031+85385+25155",0.04222914,10,314,150,8790,0.4884762,1.374388,0.031847,"ARF6//DGKQ//GRM2//MAPK1//MRAS//PDGFD//PLA2G4C//PLCB4//SHC1//SYK"]
["rno04024","cAMP signaling pathway - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04024+25650+29693+24225+50663+171140+24323+81657+25686+25643+24412+116590+290646+25594",0.04300856,13,314,214,8790,0.4884762,1.3664450000000001,0.041401,"ATP1B1//ATP2A2//BDNF//CALM2//CAMK2G//EDN1//GABBR1//GNAI1//GNAI3//GRIN2D//MAPK1//PDE4C//PPP1CB"]
["rno00051","Fructose and mannose metabolism - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno00051+116463+310935+502894+361730",0.04545713,4,314,38,8790,0.4884762,1.342398,0.012739,"AKR1B7//FPGT//TIGAR//TKFC"]
["rno04520","Adherens junction - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04520+63836+301737+116590+29645+50554+116490",0.04567768,6,314,73,8790,0.4884762,1.340296,0.019108,"ACTN4//FER//MAPK1//PTPRJ//SMAD4//SNAI1"]
["rno04915","Estrogen signaling pathway - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04915+50663+24890+25149+81657+25686+25643+116590+25031+85385",0.04655493,9,314,132,8790,0.4884762,1.332034,0.028662,"CALM2//ESR1//ESR2//GABBR1//GNAI1//GNAI3//MAPK1//PLCB4//SHC1"]
["rno00900","Terpenoid backbone biosynthesis - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno00900+291211+29637+81726",0.04714017,3,314,23,8790,0.4884762,1.326609,0.009554,"GGPS1//HMGCS1//MVD"]
["rno04917","Prolactin signaling pathway - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04917+83681+24890+25149+116590+85385+114596",0.04828376,6,314,74,8790,0.4884762,1.3161990000000001,0.019108,"CISH//ESR1//ESR2//MAPK1//SHC1//WAP"]
["rno04728","Dopaminergic synapse - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno04728+50663+171140+25432+25686+25643+114120+25750+25031+25594",0.0484415,9,314,133,8790,0.4884762,1.3147820000000001,0.028662,"CALM2//CAMK2G//DRD4//GNAI1//GNAI3//GNG12//MAOB//PLCB4//PPP1CB"]
["rno00280","Valine, leucine and isoleucine degradation - Rattus norvegicus (rat)","http://www.genome.jp/kegg-bin/show_pathway?rno00280+316421+25244+29611+301384+29637",0.04884762,5,314,56,8790,0.4884762,1.3111570000000001,0.015924,"AOX2//BCKDHA//DBT//HIBCH//HMGCS1"]