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{"sheet":"ST1","index":0,"n_rows":238,"n_cols":39,"rows_kept":238,"merged":[[1,0,1,16],[3,0,4,0],[3,1,3,2],[3,3,3,4],[3,5,3,6],[3,7,3,8],[3,9,3,10],[3,11,3,12],[3,13,3,14],[3,15,3,16],[3,17,3,18],[3,19,3,20],[3,21,3,22],[3,23,3,24],[3,25,3,26],[3,27,3,28],[3,29,3,30],[3,31,3,32],[3,33,3,34],[3,35,3,36],[3,37,3,38]]}
[]
["Supplementary Table 1. Transcriptomics data of lethal COVID-19 autopsies"]
[]
["Inflammatory genes","AT1",null,"AT2",null,"Airway epithelial cells",null,"B cells",null,"T cell CD4+",null,"T cell CD8+",null,"Tregs",null,"Cycling NK / T cells",null,"NK cells",null,"Dendritic cells",null,"Endothelial cells",null,"Fibroblast",null,"Macrophages",null,"Mast cells",null,"Monocytes",null,"Neuronal cells",null,"Other epithelial cells",null,"Plasma cells",null,"Smooth muscle"]
[{"$nulls":5},"Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%","Z","%"]
["MCPH1",{"$nulls":30},{"v":3.2,"d":"3.20"},31.78]
["MECOM",2.17,84.09,2.51,88.11]
["EDNRA",{"$nulls":22},2.22,11.41,{"$nulls":12},{"v":3.3,"d":"3.30"},16.84]
["EDNRB",{"$nulls":30},{"v":3.1,"d":"3.10"},12.79]
["EGFR",2.58,57.64]
["EIF2AK1",{"$nulls":14},3.33,{"v":14,"d":"14.00"}]
["ELF3",{"$nulls":4},3.41,42.35]
["ENPP3",{"$nulls":26},4.11,{"v":21,"d":"21.00"}]
["EPHA2",{"$nulls":4},2.61,12.03]
["ABCC1",{"$nulls":26},2.67,40.13]
["ABHD12",{"$nulls":24},{"v":3.1,"d":"3.10"},24.09]
["ABI3BP",{"$nulls":22},3.14,47.44]
["ABR",{"$nulls":24},2.78,58.59]
["ACE",{"$nulls":24},{"v":2.7,"d":"2.70"},11.73]
["ACER3",{"$nulls":26},3.12,53.27]
["ADAM17",{"$nulls":24},2.47,34.63]
["ADAMTS12",{"$nulls":22},3.88,31.77]
["AGER",{"v":4,"d":"4.00"},25.98]
["AIM2",{"$nulls":6},3.89,13.98]
["AK7",{"$nulls":4},4.12,13.04]
["AKNA",{"$nulls":16},2.45,44.42]
["ALDH2",{"$nulls":24},2.17,22.67]
["ALOX5",{"$nulls":26},2.54,45.48]
["ALOX5AP",{"$nulls":24},{"v":2,"d":"2.00"},10.01]
["METRNL",{"$nulls":24},2.54,11.91]
["MFHAS1",2.68,{"v":31.9,"d":"31.90"}]
["MGLL",3.22,46.23]
["APOE",{"$nulls":24},{"v":4,"d":"4.00"},36.32]
["APP",{"$nulls":30},{"v":3,"d":"3.00"},73.92]
["APPL2",{"$nulls":24},{"v":2.3,"d":"2.30"},22.14]
["AOAH",{"$nulls":10},2.18,67.79,{"$nulls":4},2.67,79.22]
["MS4A2",{"$nulls":26},4.13,43.25]
["SCN9A",{"$nulls":30},3.52,28.16]
["SCNN1B",2.81,20.82]
["SDC1",{"$nulls":34},2.91,14.54]
["SERPINB9",{"$nulls":18},{"v":3.1,"d":"3.10"},21.88]
["SERPINE1",{"$nulls":20},3.15,37.11]
["SERPINF1",{"$nulls":22},{"v":3.7,"d":"3.70"},12.37]
["RORA",{"$nulls":22},2.18,74.62]
["RPS19",{"$nulls":32},2.54,27.52,2.15,26.82]
["RPS6KA5",{"$nulls":26},3.15,37.62]
["NOTCH1",{"$nulls":30},3.15,19.93]
["NOTCH2",{"$nulls":28},2.52,29.71]
["NR1H3",{"$nulls":24},3.82,13.67]
["NUPR1",{"$nulls":24},2.33,10.45]
["OLR1",{"$nulls":24},3.68,28.95]
["P2RX1",{"$nulls":26},3.51,29.35]
["P2RX7",{"$nulls":24},2.88,19.99,null,null,2.37,14.95]
["ASH1L",{"$nulls":34},2.12,50.08]
["ATM",{"$nulls":16},{"v":2,"d":"2.00"},52.41]
["ATRN",{"$nulls":24},2.38,24.08]
["AXL",{"$nulls":18},2.73,15.97]
["PARP4",{"$nulls":26},3.56,49.79]
["PDCD4",{"$nulls":8},2.15,{"v":26.6,"d":"26.60"},{"v":2.3,"d":"2.30"},28.17]
["PDE2A",{"$nulls":30},{"v":4,"d":"4.00"},{"v":22,"d":"22.00"}]
["PDE5A",{"$nulls":36},3.24,36.53]
["PIK3AP1",{"$nulls":28},{"v":2,"d":"2.00"},24.39]
["PIK3CG",{"$nulls":34},2.86,16.32]
["BCL6",{"$nulls":18},2.08,34.44]
["BCR",{"$nulls":20},2.15,23.32]
["SGMS1",{"$nulls":12},2.51,38.67]
["C5AR1",{"$nulls":24},3.36,23.88]
["F3",{"v":2,"d":"2.00"},17.58,2.65,20.94]
["F8",{"$nulls":20},2.95,15.34,{"$nulls":8},2.59,17.45]
["FABP4",{"$nulls":30},3.74,10.01]
["FANCA",{"$nulls":14},3.66,26.58]
["FANCD2",{"$nulls":14},3.87,17.06]
["FCER1G",{"$nulls":24},3.21,10.89]
["FGFR1",{"$nulls":22},2.55,25.31]
["FN1",{"$nulls":22},2.76,62.95,{"$nulls":12},2.47,60.33]
["FPR1",{"$nulls":24},2.45,11.43]
["FPR3",{"$nulls":18},2.02,16.34,{"$nulls":4},3.01,23.32]
["GBP5",{"$nulls":12},2.08,15.41]
["GJA1",{"$nulls":30},3.23,21.52]
["GPRC5B",{"$nulls":30},4.04,18.05]
["GPX4",{"$nulls":24},{"v":2.6,"d":"2.60"},11.39]
["GRN",{"$nulls":24},3.86,34.69]
["GSTP1",{"$nulls":4},2.32,10.73]
["HAVCR2",{"$nulls":24},2.12,23.51]
["HCK",{"$nulls":28},2.88,27.51]
["HDAC9",{"$nulls":18},3.46,63.07]
["HGF",{"$nulls":22},3.52,16.97]
["C3",null,null,2.77,33.52,{"$nulls":18},2.39,25.79]
["SIRPA",{"$nulls":24},2.82,21.47]
["SLAMF1",{"$nulls":12},3.29,{"v":17.1,"d":"17.10"}]
["SLC11A1",{"$nulls":24},2.77,59.97,null,null,{"v":2.8,"d":"2.80"},58.29]
["SLC7A2",null,null,3.63,21.14]
["SLIT2",{"$nulls":22},3.46,63.94]
["CALCRL",{"$nulls":20},2.52,57.84,{"$nulls":8},3.05,70.65]
["CAMK1D",{"$nulls":18},2.03,{"v":60.2,"d":"60.20"}]
["CAMK4",{"$nulls":8},2.88,56.93]
["CASP4",{"$nulls":30},2.93,20.67]
["PJA2",{"$nulls":4},{"v":-2,"d":"-2.00"},11.31,{"$nulls":28},2.69,20.61]
["PLA2G4A",{"$nulls":26},2.46,14.74]
["PLA2G7",{"$nulls":24},3.98,18.96]
["PLD3",{"$nulls":24},2.77,23.62]
["PMP22",{"$nulls":22},2.76,{"v":23.6,"d":"23.60"}]
["SNAP23",2.12,21.55,{"$nulls":26},2.39,18.39]
["SNCA",{"$nulls":30},3.57,19.48]
["PPARA",{"$nulls":34},2.18,10.91]
["PPARD",{"$nulls":24},2.21,27.04,2.31,21.77]
["PPARG",{"$nulls":24},3.26,{"v":44.8,"d":"44.80"}]
["SOCS3",{"$nulls":20},2.36,10.12]
["SPN",{"$nulls":14},2.05,18.41,{"v":2.1,"d":"2.10"},14.39]
["STAB1",{"$nulls":24},2.87,18.43]
["STAP1",{"$nulls":6},3.46,16.15]
["STAT3",null,null,2.38,49.01]
["STAT5A",{"$nulls":24},2.37,14.03]
["STAT5B",{"$nulls":12},2.48,28.66]
["STK39",{"$nulls":16},2.13,42.27]
["PRCP",{"$nulls":34},2.04,11.04]
["PRKCA",{"$nulls":26},3.38,74.41]
["PRKCQ",{"$nulls":8},{"v":2,"d":"2.00"},35.75]
["PRKCZ",3.24,51.31]
["PRKD1",{"$nulls":22},2.29,44.58,{"$nulls":12},2.19,43.22]
["PSMA1",{"$nulls":12},2.05,19.57]
["PTAFR",{"$nulls":24},3.08,14.22]
["PTGDR",{"$nulls":16},3.74,17.61]
["PTGFR",null,null,4.05,23.36]
["PTGIS",{"$nulls":22},3.23,19.75]
["PTGS1",{"$nulls":26},4.08,{"v":24.9,"d":"24.90"}]
["PTGS2",3.61,11.45]
["PTPN2",{"$nulls":18},2.13,36.38,{"$nulls":14},2.28,{"v":37.1,"d":"37.10"}]
["PXK",{"$nulls":6},2.13,17.29]
["NDST1",2.73,17.85]
["NDUFS4",2.13,14.61]
["NFKB1",{"$nulls":18},3.49,34.81]
["NFKBIA",null,null,{"v":2.5,"d":"2.50"},27.75]
["NFKBID",{"$nulls":18},3.18,15.51]
["HMGB1",{"$nulls":14},2.71,45.27]
["HMGB2",{"$nulls":14},3.85,{"v":30.6,"d":"30.60"}]
["HMOX1",{"$nulls":24},3.29,26.21]
["HSPD1",{"$nulls":32},2.28,24.44]
["HYAL2",{"$nulls":20},2.45,10.58,{"$nulls":8},2.95,14.68]
["ICAM1",{"v":2.8,"d":"2.80"},{"v":31,"d":"31.00"},2.12,23.52]
["IDO1",{"$nulls":18},3.94,15.97]
["IGF1",{"$nulls":22},{"v":3,"d":"3.00"},27.34]
["IL16",{"$nulls":22},3.43,19.59]
["IL17RA",{"$nulls":28},2.82,22.17]
["IL18",2.52,26.34]
["IL18R1",{"$nulls":26},{"v":4,"d":"4.00"},80.32]
["IL18RAP",{"$nulls":16},3.71,10.32]
["IL1R1",{"$nulls":22},3.22,53.44]
["IL1R2",{"$nulls":18},2.81,15.14,{"$nulls":8},2.62,13.65]
["IL1RAP",{"$nulls":18},2.16,17.54,{"$nulls":4},{"v":2.1,"d":"2.10"},18.47]
["IL1RL1",{"$nulls":26},{"v":4,"d":"4.00"},44.85]
["IL2RA",{"$nulls":12},{"v":4,"d":"4.00"},31.43]
["IL33",{"$nulls":20},3.41,12.33]
["IRAK2",{"$nulls":30},2.26,15.77]
["ITGAM",{"$nulls":24},2.34,{"v":22.1,"d":"22.10"},null,null,2.34,18.84]
["ITGB6",2.89,38.11,2.47,{"v":34.2,"d":"34.20"}]
["JAK2",{"$nulls":18},2.31,43.31,{"$nulls":8},2.23,39.46]
["JAM3",{"$nulls":20},2.86,18.25,{"$nulls":14},2.23,19.62]
["KIT",{"$nulls":26},4.13,88.73]
["KPNA6",{"$nulls":14},2.18,14.82]
["LDLR",null,null,{"v":2.9,"d":"2.90"},44.43]
["LGALS9",{"$nulls":24},3.16,12.89]
["LIPA",{"$nulls":24},3.94,20.36]
["LPCAT3",3.29,22.99]
["LPL",{"$nulls":24},3.65,13.94]
["LRFN5",{"$nulls":22},3.86,15.07]
["LRRK2",null,null,3.77,89.63]
["LY86",{"$nulls":6},2.78,14.36]
["LY96",{"$nulls":24},{"v":2.5,"d":"2.50"},11.42]
["LYN",{"$nulls":28},2.01,{"v":55.2,"d":"55.20"}]
["MAPK14",{"$nulls":28},2.29,27.48]
["MAPKAPK2",{"$nulls":34},3.19,26.27]
["RARRES2",{"$nulls":22},3.42,11.93]
["RASGRP1",{"$nulls":12},{"v":2.4,"d":"2.40"},27.27]
["RBPJ",{"$nulls":24},2.56,62.21]
["REL",{"$nulls":18},2.75,{"v":34.9,"d":"34.90"}]
["RELB",{"$nulls":18},2.63,10.43]
["RICTOR",{"$nulls":26},-2.23,14.95]
["TBC1D23",{"$nulls":34},{"v":2.1,"d":"2.10"},13.65]
["TCIRG1",{"$nulls":24},2.52,14.95]
["TGFB1",{"$nulls":16},2.06,17.94]
["TGM2",{"$nulls":20},2.19,21.39]
["THBS1",{"$nulls":22},2.57,36.07,{"$nulls":12},2.66,37.58]
["THEMIS2",{"$nulls":24},2.35,18.81,null,null,2.07,14.67]
["TIMP1",{"$nulls":22},3.13,{"v":24.7,"d":"24.70"}]
["TLR1",{"$nulls":18},2.47,13.11]
["TLR2",{"$nulls":28},3.18,46.65]
["TLR4",{"$nulls":24},3.16,17.47]
["CCL4",{"$nulls":16},3.58,14.29]
["CCL5",{"$nulls":8},2.56,17.72,{"$nulls":6},2.64,18.87]
["CCR2",{"$nulls":34},3.92,13.08]
["CD163",{"$nulls":24},{"v":3.2,"d":"3.20"},57.94,null,null,2.23,41.28]
["CD200",{"$nulls":30},3.76,13.98]
["CD28",{"$nulls":8},2.06,{"v":11.6,"d":"11.60"},null,null,3.05,16.18]
["CD300A",{"$nulls":16},2.99,12.24]
["CD47",2.35,43.12]
["CD6",{"$nulls":8},2.87,23.35]
["CD68",{"$nulls":24},4.02,20.19]
["CD81",{"$nulls":24},2.78,19.25]
["CD96",{"$nulls":8},2.36,47.51]
["CDH5",{"$nulls":20},"3,46",{"v":23.9,"d":"23.90"}]
["CDK19",{"$nulls":14},2.76,39.52]
["TNFAIP3",{"$nulls":8},2.21,{"v":17.7,"d":"17.70"}]
["TNFRSF1B",{"$nulls":28},2.27,37.67]
["TNIP1",{"$nulls":34},2.12,11.46]
["TPSB2",{"$nulls":26},4.13,17.39]
["TRPV4",{"$nulls":4},4.01,15.86]
["UACA",{"$nulls":22},2.03,42.87]
["ULK4",{"$nulls":4},3.47,36.25]
["UNC13D",{"v":2.1,"d":"2.10"},13.07]
["VPS35",{"$nulls":18},2.09,11.82]
["ZBP1",{"$nulls":34},3.53,17.53]
["CEBPB",{"$nulls":24},2.98,34.95]
["CERS6",{"$nulls":18},2.27,43.31]
["CFH",{"$nulls":22},3.32,43.16]
["CIITA",{"$nulls":18},3.25,66.11]
["CMKLR1",{"$nulls":24},3.27,{"v":16.8,"d":"16.80"},null,null,2.03,10.74]
["CNR2",{"$nulls":6},4.05,13.28]
["CSF1",{"$nulls":26},3.74,12.93]
["CSF1R",{"$nulls":24},2.23,21.12,null,null,2.68,21.74]
["CSRP3",{"$nulls":4},4.12,{"v":12,"d":"12.00"}]
["CTNNBIP1",3.36,18.99]
["CTSC",{"$nulls":24},3.06,33.54]
["CTSS",{"$nulls":24},3.81,43.36,null,null,2.69,41.63]
["DHX9",{"$nulls":14},2.68,21.07]
["DICER1",{"$nulls":24},2.15,33.83,null,null,2.77,32.36]
["CX3CL1",{"$nulls":20},3.78,10.43]
["CXCL17",null,null,3.14,11.37]
["CXCL2",null,null,3.57,21.52]
["CYBB",{"$nulls":24},{"v":2.1,"d":"2.10"},{"v":33.2,"d":"33.20"},null,null,3.06,39.87]
["CYLD",{"$nulls":12},2.24,24.04]
["CYSLTR1",{"$nulls":6},3.11,10.24]
["DAGLB",{"$nulls":18},3.08,12.74]
["DDX3X",{"$nulls":24},2.45,24.44]
["DNASE1",{"$nulls":14},2.29,14.46]
["DROSHA",{"$nulls":26},2.87,12.45]
["DUOXA1",2.24,21.18,3.04,26.17]
["HK1",{"$nulls":28},2.04,20.93]

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[]
["Supplementary Table 2. Functional enrichment analysis"]
[]
["source","term_name","term_id","adjusted_p_value","term_size","query_size","intersection_size","effective_domain_size","intersections"]
["GO:BP","inflammatory response","GO:0006954",{"v":5.87447165684245e-226,"d":"5.87E-226"},794,235,201,18117,"MCPH1,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ACER3,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,MS4A2,SCN9A,SDC1,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,ASH1L,ATM,ATRN,AXL,PARP4,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G7,PLD3,SNAP23,SNCA,PPARA,PPARD,PPARG,SOCS3,STAB1,STAP1,STAT3,STAT5B,STK39,PRCP,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD163,CD200,CD28,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UNC13D,VPS35,ZBP1,CEBPB,CERS6,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","defense response","GO:0006952",{"v":2.37012764992613e-165,"d":"2.37E-165"},1818,235,210,18117,"MCPH1,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,MS4A2,SCN9A,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,ASH1L,ATM,ATRN,AXL,PARP4,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FCER1G,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G7,PLD3,SNAP23,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD163,CD200,CD28,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UNC13D,VPS35,ZBP1,CEBPB,CERS6,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","response to stress","GO:0006950",{"v":1.61178561945933E-95,"d":"1.61E-95"},4170,235,216,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,MS4A2,SCN9A,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,ATRN,AXL,PARP4,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FCER1G,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,SNAP23,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD163,CD200,CD28,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,ULK4,UNC13D,VPS35,ZBP1,CEBPB,CERS6,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","regulation of inflammatory response","GO:0050727",{"v":1.13844903461059E-94,"d":"1.14E-94"},381,235,104,18117,"MCPH1,EDNRB,EGFR,ENPP3,ABCC1,ABHD12,ADAMTS12,AGER,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,AOAH,SERPINE1,SERPINF1,RORA,RPS19,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,FABP4,FANCA,FANCD2,GPRC5B,GPX4,GRN,GSTP1,HCK,HGF,C3,SIRPA,CALCRL,CASP4,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT5B,STK39,PSMA1,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HSPD1,HYAL2,IDO1,IGF1,IL16,IL18,IL1R1,IL1RL1,IL2RA,IL33,JAK2,LDLR,LPCAT3,LPL,LRFN5,LRRK2,LYN,RICTOR,TGM2,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD47,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,VPS35,ZBP1,CEBPB,CNR2,CTSC,DHX9,CX3CL1,CXCL17,CYLD,DAGLB,DNASE1,DROSHA,DUOXA1"]
["GO:BP","regulation of response to external stimulus","GO:0032101",{"v":5.4225688175128e-90,"d":"5.42E-90"},1051,235,137,18117,"MCPH1,EDNRB,EGFR,ENPP3,ABCC1,ABHD12,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HGF,C3,SIRPA,SLIT2,CALCRL,CAMK1D,CASP4,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT5B,STK39,PRKCA,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,IDO1,IGF1,IL16,IL18,IL18RAP,IL1R1,IL1RL1,IL2RA,IL33,JAK2,JAM3,LDLR,LGALS9,LPCAT3,LPL,LRFN5,LRRK2,LY86,LY96,LYN,RARRES2,RASGRP1,RELB,RICTOR,TGM2,THBS1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD47,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,VPS35,ZBP1,CEBPB,CMKLR1,CNR2,CSF1,CSF1R,CTSC,DHX9,CX3CL1,CXCL17,CYLD,DAGLB,DNASE1,DROSHA,DUOXA1"]
["GO:BP","regulation of defense response","GO:0031347",{"v":3.38510724766802e-87,"d":"3.39E-87"},704,235,119,18117,"MCPH1,EDNRB,EGFR,ENPP3,ABCC1,ABHD12,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,FABP4,FANCA,FANCD2,FCER1G,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HGF,C3,SIRPA,CALCRL,CASP4,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT5B,STK39,PSMA1,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,IDO1,IGF1,IL16,IL18,IL18RAP,IL1R1,IL1RL1,IL2RA,IL33,JAK2,LDLR,LGALS9,LPCAT3,LPL,LRFN5,LRRK2,LYN,RASGRP1,RELB,RICTOR,TGM2,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD47,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,VPS35,ZBP1,CEBPB,CNR2,CTSC,DHX9,CX3CL1,CXCL17,CYLD,DAGLB,DNASE1,DROSHA,DUOXA1"]
["GO:BP","response to external stimulus","GO:0009605",{"v":2.81019267546238e-75,"d":"2.81E-75"},2944,235,179,18117,"MCPH1,EDNRB,EGFR,EIF2AK1,ENPP3,EPHA2,ABCC1,ABHD12,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CASP4,PJA2,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT5B,STK39,PRKCA,PRKCQ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18RAP,IL1R1,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TGFB1,TGM2,THBS1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UNC13D,VPS35,ZBP1,CEBPB,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTSC,DHX9,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","regulation of response to stress","GO:0080134",{"v":2.86841881789046E-59,"d":"2.87E-59"},1443,235,128,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ENPP3,ABCC1,ABCD1,ABHD12,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,F3,FABP4,FANCA,FANCD2,FCER1G,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HGF,C3,SIRPA,SLAMF1,CALCRL,CASP4,PJA2,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT5B,STK39,PSMA1,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,IDO1,IGF1,IL16,IL18,IL18RAP,IL1R1,IL1RL1,IL2RA,IL33,JAK2,LDLR,LGALS9,LPCAT3,LPL,LRFN5,LRRK2,LYN,MAPKAPK2,RASGRP1,RELB,RICTOR,TGM2,THBS1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD47,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,ULK4,VPS35,ZBP1,CEBPB,CNR2,CTSC,DHX9,CX3CL1,CXCL17,CYLD,DAGLB,DNASE1,DROSHA,DUOXA1"]
["GO:BP","regulation of response to stimulus","GO:0048583",{"v":2.87713323806594e-54,"d":"2.88E-54"},4278,235,186,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABR,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,MS4A2,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CASP4,PJA2,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NDST1,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,JAK2,JAM3,KIT,LDLR,LGALS9,LPCAT3,LPL,LRFN5,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,UNC13D,VPS35,ZBP1,CEBPB,CFH,CMKLR1,CNR2,CSF1,CSF1R,CTNNBIP1,CTSC,DHX9,CX3CL1,CXCL17,CYLD,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1"]
["GO:BP","positive regulation of response to external stimulus","GO:0032103",{"v":2.83286788016558e-47,"d":"2.83E-47"},513,235,81,18117,"EGFR,ABCC1,ADAM17,AGER,AIM2,ALOX5AP,APP,SERPINE1,RPS19,RPS6KA5,NUPR1,PDCD4,PDE2A,PIK3CG,C5AR1,F3,FABP4,FCER1G,FGFR1,GBP5,GPRC5B,GRN,HAVCR2,HCK,C3,SLIT2,CAMK1D,PLA2G7,SNCA,STAP1,STAT5B,STK39,PRKCA,PRKD1,PSMA1,PTGS2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,IDO1,IL16,IL18,IL18RAP,IL1RL1,IL33,JAK2,LDLR,LGALS9,LPL,LRRK2,LY86,LY96,LYN,RARRES2,RASGRP1,RELB,TGM2,THBS1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD47,CD81,CDK19,TNIP1,TRPV4,ZBP1,CEBPB,CMKLR1,CSF1,CSF1R,CTSC,DHX9,CX3CL1,CXCL17"]
["GO:BP","cytokine production","GO:0001816",{"v":9.45402714530048e-47,"d":"9.45E-47"},844,235,95,18117,"EPHA2,ABCD1,ADAM17,AGER,AIM2,ALOX5,APP,APPL2,SERPINE1,RORA,RPS6KA5,P2RX7,AXL,PDCD4,PIK3CG,BCL6,C5AR1,F3,FCER1G,FN1,GBP5,GPRC5B,GSTP1,HAVCR2,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,PLD3,PPARA,SPN,STAT3,STAT5B,PRKCQ,PRKCZ,PTAFR,PTGS2,NFKB1,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL1R1,IL1R2,IL1RAP,IL1RL1,IL33,ITGB6,JAK2,KIT,KPNA6,LGALS9,LPL,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,REL,RELB,TGFB1,THBS1,TLR1,TLR2,TLR4,CCR2,CD200,CD28,CD47,CD6,CD81,CD96,TNFAIP3,TNFRSF1B,TRPV4,ZBP1,CEBPB,CMKLR1,CSF1R,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,HK1"]
["GO:BP","regulation of cytokine production","GO:0001817",{"v":2.929317999471e-46,"d":"2.93E-46"},806,235,93,18117,"EPHA2,ABCD1,ADAM17,AGER,AIM2,ALOX5,APP,APPL2,SERPINE1,RORA,RPS6KA5,P2RX7,AXL,PDCD4,BCL6,C5AR1,F3,FCER1G,FN1,GBP5,GPRC5B,GSTP1,HAVCR2,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,PLD3,PPARA,SPN,STAT3,STAT5B,PRKCQ,PRKCZ,PTAFR,PTGS2,NFKB1,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL1R1,IL1R2,IL1RAP,IL1RL1,IL33,ITGB6,JAK2,KPNA6,LGALS9,LPL,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,REL,RELB,TGFB1,THBS1,TLR1,TLR2,TLR4,CCR2,CD200,CD28,CD47,CD6,CD81,CD96,TNFAIP3,TNFRSF1B,TRPV4,ZBP1,CEBPB,CMKLR1,CSF1R,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,HK1"]
["GO:BP","immune system process","GO:0002376",{"v":8.9503275011e-46,"d":"8.95E-46"},3278,235,159,18117,"MECOM,EDNRB,EIF2AK1,ENPP3,EPHA2,ACE,ADAM17,AGER,AIM2,ALOX5,MFHAS1,APOE,APP,APPL2,MS4A2,SDC1,SERPINB9,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,OLR1,P2RX1,ATM,AXL,PDE2A,PIK3CG,BCL6,C5AR1,FANCA,FANCD2,FCER1G,FN1,FPR1,FPR3,GBP5,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,SNAP23,SNCA,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTPN2,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LRFN5,LRRK2,LY86,LY96,LYN,MAPK14,RARRES2,RASGRP1,RBPJ,REL,RELB,TCIRG1,TGFB1,THBS1,THEMIS2,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD68,CD81,CD96,TNFAIP3,TNFRSF1B,TRPV4,UNC13D,ZBP1,CEBPB,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CTNNBIP1,CTSC,CTSS,DHX9,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DDX3X,DNASE1,DROSHA,HK1"]
["GO:BP","regulation of immune system process","GO:0002682",{"v":1.54691021003795e-41,"d":"1.55E-41"},1617,235,117,18117,"ENPP3,ADAM17,AGER,AIM2,MFHAS1,APOE,APP,APPL2,MS4A2,SERPINB9,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH2,NR1H3,ATM,AXL,BCL6,C5AR1,FANCA,FANCD2,FCER1G,FPR1,FPR3,GBP5,GPRC5B,GRN,HAVCR2,HCK,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,PJA2,PLA2G4A,PLA2G7,SNCA,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PSMA1,PTAFR,PTPN2,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1R1,IL1RL1,IL2RA,IL33,ITGAM,JAK2,JAM3,KIT,LDLR,LGALS9,LRFN5,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,RELB,TGFB1,THBS1,THEMIS2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD68,CD81,CD96,TNFAIP3,TNFRSF1B,TRPV4,UNC13D,ZBP1,CEBPB,CFH,CMKLR1,CNR2,CSF1,CSF1R,CTNNBIP1,CTSC,DHX9,CX3CL1,CXCL17,DNASE1,DROSHA,HK1"]
["GO:BP","regulation of multicellular organismal process","GO:0051239",{"v":1.80637407445878e-38,"d":"1.81E-38"},2861,235,144,18117,"EDNRB,EGFR,EPHA2,ABCD1,ACE,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,MGLL,APOE,APP,APPL2,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ATRN,AXL,PDCD4,PIK3CG,BCL6,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,GBP5,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK4,PLD3,PPARA,PPARD,PPARG,SPN,STAB1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,ITGB6,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,REL,RELB,TGFB1,THBS1,TIMP1,TLR1,TLR2,TLR4,CCR2,CD200,CD28,CD47,CD6,CD81,CD96,CDH5,TNFAIP3,TNFRSF1B,TRPV4,ZBP1,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CXCL17,CYBB,CYLD,DDX3X,DROSHA,HK1"]
["GO:BP","positive regulation of response to stimulus","GO:0048584",{"v":5.95643658531683e-39,"d":"5.96E-39"},2344,235,132,18117,"EGFR,ELF3,ABCC1,ADAM17,AGER,AIM2,ALOX5AP,MFHAS1,APOE,APP,APPL2,SERPINE1,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,AXL,PDCD4,PDE2A,PIK3AP1,PIK3CG,C5AR1,F3,FABP4,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GRN,HAVCR2,HCK,HGF,C3,SLAMF1,SLC11A1,SLIT2,CAMK1D,CASP4,PJA2,PLA2G4A,PLA2G7,SNCA,PPARD,STAP1,STAT3,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NDST1,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL18,IL18R1,IL18RAP,IL1R1,IL1RL1,IL33,IRAK2,ITGAM,JAK2,KIT,LDLR,LGALS9,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TGM2,THBS1,THEMIS2,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD81,CDH5,CDK19,TNFAIP3,TNIP1,TRPV4,VPS35,ZBP1,CEBPB,CFH,CMKLR1,CSF1,CSF1R,CTSC,DHX9,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","immune response","GO:0006955",{"v":8.34246092857309e-38,"d":"8.34E-38"},2311,235,130,18117,"ENPP3,ADAM17,AGER,AIM2,ALOX5,MFHAS1,APOE,APP,APPL2,MS4A2,SERPINB9,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,OLR1,P2RX1,AXL,PIK3CG,BCL6,C5AR1,FCER1G,FPR1,FPR3,GBP5,GPRC5B,GRN,GSTP1,HAVCR2,HCK,C3,SIRPA,SLAMF1,SLC11A1,CAMK4,CASP4,PJA2,PLA2G4A,SNAP23,SNCA,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5B,PRCP,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTPN2,NFKB1,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,ICAM1,IDO1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LY86,LY96,LYN,MAPK14,RARRES2,RASGRP1,RBPJ,REL,RELB,TCIRG1,TGFB1,THBS1,THEMIS2,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD68,CD81,CD96,TNFAIP3,TNFRSF1B,UNC13D,ZBP1,CEBPB,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CTSC,CTSS,DHX9,CX3CL1,CXCL2,CYBB,CYLD,CYSLTR1,DDX3X,DNASE1,HK1"]
["GO:BP","response to stimulus","GO:0050896",{"v":1.49586695770081e-35,"d":"1.50E-35"},9407,235,227,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABR,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,MS4A2,SCN9A,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,ATRN,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,SNAP23,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD163,CD200,CD28,CD300A,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,UNC13D,VPS35,ZBP1,CEBPB,CERS6,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","cellular response to chemical stimulus","GO:0070887",{"v":3.24129767801685e-35,"d":"3.24E-35"},3393,235,151,18117,"EDNRB,EGFR,EPHA2,ABCC1,ABCD1,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,ALOX5AP,APOE,APP,APPL2,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,P2RX7,ATM,AXL,PDCD4,PDE2A,PIK3CG,BCL6,SGMS1,C5AR1,F3,FABP4,FANCD2,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPX4,GSTP1,HAVCR2,HCK,HDAC9,HGF,SIRPA,SLIT2,CALCRL,CAMK1D,CASP4,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RBPJ,RELB,TCIRG1,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD47,CD6,CD68,CDH5,CDK19,TNFAIP3,TNFRSF1B,TRPV4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTSS,DHX9,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,DDX3X"]
["GO:BP","response to other organism","GO:0051707",{"v":2.45313820100156E-35,"d":"2.45E-35"},1592,235,109,18117,"EDNRB,EPHA2,ADAM17,AGER,AIM2,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,AXL,PDCD4,PIK3CG,SGMS1,C5AR1,FABP4,FCER1G,GBP5,GJA1,GRN,GSTP1,HAVCR2,HCK,C3,SIRPA,SLAMF1,SLC11A1,CASP4,PJA2,SNCA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT5B,PRKCA,PRKD1,PSMA1,PTAFR,PTGFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,ICAM1,IDO1,IL17RA,IL18,IL18RAP,IL1RAP,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,KPNA6,LGALS9,LPL,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,TLR1,TLR2,TLR4,CCL4,CCL5,CD47,CD6,CD68,CD96,CDK19,TNFAIP3,TNFRSF1B,UNC13D,ZBP1,CEBPB,CFH,CIITA,CNR2,CSF1,CSF1R,DHX9,CX3CL1,CXCL2,CYBB,CYLD,DDX3X,DROSHA,HK1"]
["GO:BP","response to external biotic stimulus","GO:0043207",{"v":2.65156045195314e-34,"d":"2.65E-34"},1594,235,109,18117,"EDNRB,EPHA2,ADAM17,AGER,AIM2,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,AXL,PDCD4,PIK3CG,SGMS1,C5AR1,FABP4,FCER1G,GBP5,GJA1,GRN,GSTP1,HAVCR2,HCK,C3,SIRPA,SLAMF1,SLC11A1,CASP4,PJA2,SNCA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT5B,PRKCA,PRKD1,PSMA1,PTAFR,PTGFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,ICAM1,IDO1,IL17RA,IL18,IL18RAP,IL1RAP,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,KPNA6,LGALS9,LPL,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,TLR1,TLR2,TLR4,CCL4,CCL5,CD47,CD6,CD68,CD96,CDK19,TNFAIP3,TNFRSF1B,UNC13D,ZBP1,CEBPB,CFH,CIITA,CNR2,CSF1,CSF1R,DHX9,CX3CL1,CXCL2,CYBB,CYLD,DDX3X,DROSHA,HK1"]
["GO:BP","cell activation","GO:0001775",{"v":3.86451367450833E-35,"d":"3.86E-35"},1495,235,106,18117,"EGFR,ENPP3,ADAM17,AGER,ALOX5,MFHAS1,APOE,APP,RORA,NOTCH2,NR1H3,OLR1,P2RX1,ATM,AXL,PIK3CG,BCL6,C5AR1,F8,FANCA,FANCD2,FCER1G,FN1,FPR1,GRN,GSTP1,HAVCR2,HDAC9,C3,SIRPA,SLAMF1,SLC11A1,CAMK4,PJA2,PLA2G4A,SNAP23,SNCA,SPN,STAP1,STAT3,STAT5B,PRCP,PRKCA,PRKCQ,PRKCZ,PTAFR,PTGDR,PTPN2,NFKB1,NFKBID,HMGB1,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL17RA,IL18,IL18R1,IL18RAP,IL1RL1,IL2RA,IL33,ITGAM,ITGB6,JAK2,KIT,LDLR,LGALS9,LRFN5,LRRK2,LYN,MAPK14,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD68,CD81,TNFAIP3,TNFRSF1B,UNC13D,CEBPB,CNR2,CSF1,CTSC,CTSS,CX3CL1,CYBB,DDX3X,DNASE1,DROSHA"]
["GO:BP","positive regulation of inflammatory response","GO:0050729",{"v":7.36840501060284E-35,"d":"7.37E-35"},142,235,46,18117,"EGFR,ABCC1,ALOX5AP,APP,SERPINE1,RPS19,NUPR1,PDCD4,PDE2A,PIK3CG,FABP4,GPRC5B,GRN,C3,PLA2G7,SNCA,STAP1,STAT5B,PTGS2,NFKBIA,HSPD1,HYAL2,IDO1,IL16,IL18,IL1RL1,IL33,JAK2,LDLR,LPL,LRRK2,TGM2,TLR2,TLR4,CCR2,CD28,CD47,CD81,CDK19,TNIP1,TRPV4,ZBP1,CEBPB,CTSC,DHX9,CX3CL1"]
["GO:BP","positive regulation of defense response","GO:0031349",{"v":1.27272887495252E-33,"d":"1.27E-33"},362,235,62,18117,"EGFR,ABCC1,AIM2,ALOX5AP,APP,SERPINE1,RPS19,RPS6KA5,NUPR1,PDCD4,PDE2A,PIK3CG,FABP4,FCER1G,GBP5,GJA1,GPRC5B,GRN,HAVCR2,HCK,C3,PLA2G7,SNCA,STAP1,STAT5B,PSMA1,PTGS2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,IDO1,IL16,IL18,IL18RAP,IL1RL1,IL33,JAK2,LDLR,LPL,LRRK2,LYN,RASGRP1,RELB,TGM2,TLR2,TLR4,CCL5,CCR2,CD28,CD47,CD81,CDK19,TNIP1,TRPV4,ZBP1,CEBPB,CTSC,DHX9,CX3CL1"]
["GO:BP","response to biotic stimulus","GO:0009607",{"v":1.6460501739611e-33,"d":"1.65E-33"},1626,235,109,18117,"EDNRB,EPHA2,ADAM17,AGER,AIM2,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,AXL,PDCD4,PIK3CG,SGMS1,C5AR1,FABP4,FCER1G,GBP5,GJA1,GRN,GSTP1,HAVCR2,HCK,C3,SIRPA,SLAMF1,SLC11A1,CASP4,PJA2,SNCA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT5B,PRKCA,PRKD1,PSMA1,PTAFR,PTGFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,ICAM1,IDO1,IL17RA,IL18,IL18RAP,IL1RAP,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,KPNA6,LGALS9,LPL,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,TLR1,TLR2,TLR4,CCL4,CCL5,CD47,CD6,CD68,CD96,CDK19,TNFAIP3,TNFRSF1B,UNC13D,ZBP1,CEBPB,CFH,CIITA,CNR2,CSF1,CSF1R,DHX9,CX3CL1,CXCL2,CYBB,CYLD,DDX3X,DROSHA,HK1"]
["GO:BP","response to organic substance","GO:0010033",{"v":3.1514643164664e-33,"d":"3.15E-33"},3412,235,149,18117,"EDNRB,EGFR,EPHA2,ABCC1,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,APOE,APP,APPL2,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,P2RX1,P2RX7,ATM,AXL,PDCD4,PDE2A,PIK3CG,BCL6,SGMS1,C5AR1,F3,FABP4,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPX4,GSTP1,HAVCR2,HCK,HDAC9,HGF,SIRPA,SLC11A1,SLIT2,CALCRL,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,KIT,LDLR,LGALS9,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RBPJ,REL,RELB,TCIRG1,TGFB1,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TRPV4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTSC,CTSS,DHX9,CX3CL1,CXCL2,CYBB,CYLD"]
["GO:BP","leukocyte activation","GO:0045321",{"v":4.65099984367732e-32,"d":"4.65E-32"},1332,235,99,18117,"ENPP3,ADAM17,AGER,ALOX5,MFHAS1,APP,RORA,NOTCH2,NR1H3,OLR1,P2RX1,ATM,AXL,PIK3CG,BCL6,C5AR1,FANCA,FANCD2,FCER1G,FPR1,GRN,GSTP1,HAVCR2,HDAC9,C3,SIRPA,SLAMF1,SLC11A1,CAMK4,PJA2,PLA2G4A,SNAP23,SNCA,SPN,STAP1,STAT3,STAT5B,PRCP,PRKCQ,PRKCZ,PTAFR,PTGDR,PTPN2,NFKB1,NFKBID,HMGB1,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RL1,IL2RA,IL33,ITGAM,ITGB6,JAK2,KIT,LDLR,LGALS9,LRFN5,LRRK2,LYN,MAPK14,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,THBS1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD68,CD81,TNFAIP3,TNFRSF1B,UNC13D,CEBPB,CNR2,CSF1,CTSC,CTSS,CX3CL1,CYBB,DDX3X,DNASE1,DROSHA"]
["GO:BP","myeloid leukocyte activation","GO:0002274",{"v":2.23662843057455e-31,"d":"2.24E-31"},667,235,75,18117,"ENPP3,AGER,ALOX5,MFHAS1,APP,RORA,NOTCH2,NR1H3,OLR1,P2RX1,ATM,PIK3CG,C5AR1,FCER1G,FPR1,GRN,GSTP1,HAVCR2,C3,SIRPA,SLAMF1,SLC11A1,CAMK4,PJA2,PLA2G4A,SNAP23,SNCA,STAP1,PRCP,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,HSPD1,HYAL2,IL18,IL18RAP,IL1RL1,IL33,ITGAM,ITGB6,JAK2,KIT,LDLR,LGALS9,LRFN5,LRRK2,LYN,MAPK14,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,THBS1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CNR2,CSF1,CTSC,CTSS,CX3CL1,CYBB,DDX3X,DNASE1"]
["GO:BP","positive regulation of cytokine production","GO:0001819",{"v":2.85303747828665e-31,"d":"2.85E-31"},452,235,65,18117,"ADAM17,AGER,AIM2,APP,SERPINE1,RORA,P2RX7,C5AR1,F3,FCER1G,GBP5,GPRC5B,HAVCR2,HGF,C3,SLC11A1,SPN,STAT3,STAT5B,PRKCQ,PRKCZ,PTAFR,PTGS2,NFKB1,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,IDO1,IL16,IL17RA,IL18,IL18R1,IL1R1,IL1RAP,IL1RL1,IL33,JAK2,KPNA6,LGALS9,LPL,LY96,MAPK14,MAPKAPK2,RASGRP1,TGFB1,THBS1,TLR1,TLR2,TLR4,CCR2,CD200,CD28,CD6,CD81,TRPV4,ZBP1,CEBPB,CSF1R,DHX9,CX3CL1,CXCL17,DDX3X,HK1"]
["GO:BP","biological process involved in interspecies interaction between organisms","GO:0044419",{"v":7.44082035844255e-32,"d":"7.44E-32"},2255,235,122,18117,"EDNRB,EGFR,EPHA2,ADAM17,AGER,AIM2,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,P2RX7,AXL,PDCD4,PIK3CG,SGMS1,C5AR1,FABP4,FCER1G,FN1,GBP5,GJA1,GRN,GSTP1,HAVCR2,HCK,C3,SIRPA,SLAMF1,SLC11A1,CASP4,PJA2,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5B,PRKCA,PRKD1,PSMA1,PTAFR,PTGFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,ICAM1,IDO1,IL16,IL17RA,IL18,IL18RAP,IL1RAP,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,KPNA6,LDLR,LGALS9,LPL,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD47,CD6,CD68,CD81,CD96,CDK19,TNFAIP3,TNFRSF1B,TNIP1,UNC13D,VPS35,ZBP1,CEBPB,CFH,CIITA,CNR2,CSF1,CSF1R,DHX9,CX3CL1,CXCL2,CYBB,CYLD,DDX3X,DROSHA,HK1"]
["GO:BP","cellular response to organic substance","GO:0071310",{"v":2.16796085963448e-31,"d":"2.17E-31"},2776,235,133,18117,"EDNRB,EGFR,ABCC1,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,APP,APPL2,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,P2RX7,ATM,AXL,PDCD4,PDE2A,PIK3CG,BCL6,SGMS1,F3,FABP4,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GSTP1,HAVCR2,HCK,HDAC9,HGF,SIRPA,SLIT2,CALCRL,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,KIT,LDLR,LGALS9,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RBPJ,TCIRG1,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD47,CD6,CD68,CDH5,CDK19,TNFAIP3,TNFRSF1B,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTSS,DHX9,CX3CL1,CXCL2,CYBB,CYLD"]
["GO:BP","positive regulation of multicellular organismal process","GO:0051240",{"v":1.40399599288641E-29,"d":"1.40E-29"},1455,235,100,18117,"EDNRB,EGFR,ADAM17,AGER,AIM2,ALOX5,APOE,APP,APPL2,SERPINE1,SERPINF1,RORA,RPS19,NOTCH1,NOTCH2,P2RX7,AXL,BCL6,C5AR1,F3,FABP4,FCER1G,FN1,GBP5,GJA1,GPRC5B,GRN,HAVCR2,HGF,C3,SLC11A1,SLIT2,PPARG,SPN,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGIS,PTGS2,NFKB1,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL1R1,IL1RAP,IL1RL1,IL2RA,IL33,JAK2,KIT,KPNA6,LGALS9,LPCAT3,LPL,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,TGFB1,THBS1,TLR1,TLR2,TLR4,CCR2,CD200,CD28,CD6,CD81,CDH5,TNFRSF1B,TRPV4,ZBP1,CEBPB,CMKLR1,CSF1,CSF1R,CTNNBIP1,DHX9,DICER1,CX3CL1,CXCL17,CYBB,DDX3X,HK1"]
["GO:BP","positive regulation of biological process","GO:0048518",{"v":3.03269621190696e-28,"d":"3.03E-28"},6363,235,189,18117,"MECOM,EDNRB,EGFR,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABI3BP,ABR,ACE,ACER3,ADAM17,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,APOE,APP,APPL2,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,SGMS1,C5AR1,F3,FABP4,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,UNC13D,VPS35,ZBP1,CEBPB,CFH,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYBB,CYLD,DAGLB,DDX3X,DROSHA,DUOXA1,HK1"]
["GO:BP","response to chemical","GO:0042221",{"v":9.35432914431383e-29,"d":"9.35E-29"},4781,235,166,18117,"EDNRB,EGFR,EPHA2,ABCC1,ABCD1,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,ALOX5AP,APOE,APP,APPL2,SCN9A,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ATM,AXL,PARP4,PDCD4,PDE2A,PIK3CG,BCL6,SGMS1,C5AR1,F3,FABP4,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPX4,GSTP1,HAVCR2,HCK,HDAC9,HGF,SIRPA,SLC11A1,SLIT2,CALCRL,CAMK1D,CASP4,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RBPJ,REL,RELB,TCIRG1,TGFB1,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TRPV4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTSC,CTSS,DHX9,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DDX3X"]
["GO:BP","positive regulation of immune system process","GO:0002684",{"v":1.36916682063511E-26,"d":"1.37E-26"},1065,235,85,18117,"ENPP3,ADAM17,AGER,AIM2,APP,APPL2,SERPINE1,RPS19,RPS6KA5,NOTCH2,AXL,BCL6,C5AR1,FCER1G,FPR1,FPR3,GBP5,GPRC5B,HAVCR2,HCK,C3,SIRPA,SLC11A1,CAMK1D,PLA2G4A,PLA2G7,SPN,STAP1,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PSMA1,PTAFR,PTPN2,NFKB1,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1R1,IL1RL1,IL2RA,IL33,ITGAM,JAM3,LGALS9,LRRK2,LYN,RARRES2,RASGRP1,RELB,TGFB1,THBS1,THEMIS2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,TRPV4,UNC13D,ZBP1,CFH,CMKLR1,CSF1,CSF1R,CTNNBIP1,CTSC,DHX9,CX3CL1,CXCL17,HK1"]
["GO:BP","positive regulation of gene expression","GO:0010628",{"v":1.43872584021241e-26,"d":"1.44E-26"},1160,235,88,18117,"EGFR,ADAM17,AGER,AIM2,APP,SERPINB9,SERPINE1,RORA,NOTCH1,P2RX7,ATM,PDE2A,SGMS1,C5AR1,F3,FCER1G,FN1,GBP5,GJA1,GPRC5B,HAVCR2,HGF,C3,SLC11A1,PPARD,PPARG,SPN,STAP1,STAT3,STAT5B,PRKCQ,PRKCZ,PTAFR,PTGFR,PTGS2,NFKB1,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL1R1,IL1RAP,IL1RL1,IL33,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LY96,MAPK14,MAPKAPK2,RASGRP1,RBPJ,RELB,TGFB1,THBS1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD6,CD81,CDH5,TRPV4,VPS35,ZBP1,CEBPB,CSF1,CSF1R,DHX9,CX3CL1,CXCL17,DDX3X,DROSHA,HK1"]
["GO:BP","response to cytokine","GO:0034097",{"v":1.53292013333079e-27,"d":"1.53E-27"},1226,235,90,18117,"ADAM17,ADAMTS12,AIM2,ALOX5,APP,APPL2,SDC1,RORA,RPS6KA5,NR1H3,AXL,PDCD4,PDE2A,BCL6,SGMS1,F3,FABP4,FCER1G,FN1,FPR1,GBP5,GSTP1,HCK,HGF,SIRPA,SLC11A1,SLIT2,CASP4,SNCA,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRKCA,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMOX1,HSPD1,HYAL2,ICAM1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,JAK2,KIT,LGALS9,MAPK14,MAPKAPK2,REL,RELB,TCIRG1,THBS1,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD47,TNFAIP3,TNFRSF1B,ZBP1,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,DHX9,CX3CL1,CXCL2,CYLD"]
["GO:BP","cellular response to cytokine stimulus","GO:0071345",{"v":1.24739931620229e-22,"d":"1.25E-22"},1132,235,83,18117,"ADAM17,ADAMTS12,AIM2,ALOX5,APPL2,SDC1,RORA,RPS6KA5,NR1H3,AXL,PDCD4,PDE2A,BCL6,SGMS1,F3,FABP4,FCER1G,FN1,FPR1,GBP5,GSTP1,HCK,HGF,SIRPA,SLIT2,CASP4,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMOX1,HSPD1,HYAL2,ICAM1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,JAK2,KIT,LGALS9,MAPK14,TCIRG1,THBS1,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD47,TNFAIP3,TNFRSF1B,ZBP1,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,DHX9,CX3CL1,CXCL2,CYLD"]
["GO:BP","response to oxygen-containing compound","GO:1901700",{"v":8.3349065985621e-23,"d":"8.33E-23"},1739,235,99,18117,"EDNRB,EGFR,ABCC1,ADAM17,AGER,APOE,APP,APPL2,SCNN1B,SDC1,SERPINE1,SERPINF1,RORA,NOTCH1,NR1H3,P2RX1,P2RX7,ATM,AXL,PDCD4,PDE2A,PIK3CG,SGMS1,C5AR1,GJA1,GPX4,GSTP1,HAVCR2,HCK,HDAC9,HGF,SIRPA,SLC11A1,SLIT2,CALCRL,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGFR,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18RAP,IRAK2,JAK2,LDLR,LGALS9,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,TCIRG1,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL5,CD6,CD68,CD96,CDK19,TNFAIP3,TNFRSF1B,TRPV4,VPS35,CEBPB,CNR2,CSRP3,CX3CL1,CXCL2,CYBB"]
["GO:BP","response to lipopolysaccharide","GO:0032496",{"v":1.71764832486111e-21,"d":"1.72E-21"},338,235,51,18117,"EDNRB,ADAM17,SERPINE1,NOTCH1,NR1H3,AXL,PDCD4,SGMS1,C5AR1,GJA1,GSTP1,HAVCR2,HCK,SIRPA,SLC11A1,SNCA,PPARD,STAP1,PRKCA,PTAFR,PTGFR,PTGS2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,ICAM1,IDO1,IL18,IRAK2,JAK2,LGALS9,LY86,LY96,LYN,MAPK14,MAPKAPK2,TLR2,TLR4,CCL5,CD6,CD68,CD96,CDK19,TNFAIP3,TNFRSF1B,CEBPB,CNR2,CX3CL1,CXCL2"]
["GO:BP","response to molecule of bacterial origin","GO:0002237",{"v":3.0955088257528e-21,"d":"3.10E-21"},361,235,52,18117,"EDNRB,ADAM17,SERPINE1,NOTCH1,NR1H3,AXL,PDCD4,SGMS1,C5AR1,GJA1,GSTP1,HAVCR2,HCK,SIRPA,SLC11A1,SNCA,PPARD,STAP1,PRKCA,PTAFR,PTGFR,PTGS2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,ICAM1,IDO1,IL18,IRAK2,JAK2,LGALS9,LY86,LY96,LYN,MAPK14,MAPKAPK2,TLR1,TLR2,TLR4,CCL5,CD6,CD68,CD96,CDK19,TNFAIP3,TNFRSF1B,CEBPB,CNR2,CX3CL1,CXCL2"]
["GO:BP","positive regulation of cellular process","GO:0048522",{"v":5.26415871574453e-22,"d":"5.26E-22"},5757,235,172,18117,"MECOM,EDNRB,EGFR,ELF3,EPHA2,ABCD1,ABI3BP,ABR,ACE,ACER3,ADAM17,AGER,AIM2,AKNA,ALOX5,METRNL,MFHAS1,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PDCD4,PIK3AP1,PIK3CG,BCL6,C5AR1,F3,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1R1,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,UNC13D,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DAGLB,DDX3X,DUOXA1"]
["GO:BP","cellular response to stimulus","GO:0051716",{"v":1.6139821610512e-21,"d":"1.61E-21"},7781,235,197,18117,"MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCC1,ABCD1,ABR,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,MS4A2,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD68,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X"]
["GO:BP","defense response to other organism","GO:0098542",{"v":2.73395597712436e-20,"d":"2.73E-20"},1218,235,83,18117,"EPHA2,ADAM17,AGER,AIM2,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,RPS19,RPS6KA5,NOTCH2,NR1H3,AXL,PIK3CG,C5AR1,FCER1G,GBP5,GRN,HAVCR2,HCK,C3,SIRPA,SLAMF1,SLC11A1,CASP4,PJA2,SNCA,PPARG,SOCS3,SPN,STAB1,STAT5B,PRKD1,PSMA1,PTAFR,PTPN2,NFKB1,HMGB1,HMGB2,HYAL2,ICAM1,IL17RA,IL18,IL18RAP,IL1RAP,IL2RA,IL33,ITGAM,JAK2,LGALS9,LY86,LY96,LYN,RARRES2,RASGRP1,RBPJ,REL,RELB,TLR1,TLR2,TLR4,CCL4,CCL5,CD47,CD6,CD96,TNFAIP3,UNC13D,ZBP1,CEBPB,CFH,CIITA,CSF1,CSF1R,DHX9,CX3CL1,CYBB,CYLD,DDX3X,DROSHA,HK1"]
["GO:BP","regulation of cell activation","GO:0050865",{"v":4.11623638190792E-21,"d":"4.12E-21"},655,235,64,18117,"ENPP3,AGER,MFHAS1,APOE,RORA,NR1H3,ATM,AXL,BCL6,FANCA,FANCD2,FCER1G,GRN,HAVCR2,SIRPA,CAMK4,PJA2,PLA2G4A,SNCA,SPN,STAP1,STAT5B,PRKCA,PRKCQ,PRKCZ,PTAFR,PTPN2,NFKBID,HMGB1,HMOX1,HSPD1,IDO1,IGF1,IL18,IL1RL1,IL2RA,IL33,ITGAM,JAK2,LDLR,LGALS9,LRFN5,LRRK2,LYN,RASGRP1,TGFB1,THBS1,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,TNFAIP3,TNFRSF1B,UNC13D,CEBPB,CNR2,CTSC,CX3CL1,DROSHA"]
["GO:BP","cell surface receptor signaling pathway","GO:0007166",{"v":4.13846364137591e-21,"d":"4.14E-21"},3210,235,129,18117,"EDNRB,EGFR,ELF3,EPHA2,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,APOE,APP,APPL2,MS4A2,SDC1,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,P2RX1,P2RX7,AXL,PDCD4,BCL6,BCR,C5AR1,F3,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GPRC5B,GSTP1,HCK,HGF,C3,SLAMF1,SLIT2,CALCRL,CASP4,SNCA,PPARA,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGS2,PTPN2,NDST1,NFKB1,NFKBIA,NFKBID,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,KIT,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RBPJ,RELB,TCIRG1,TGFB1,THBS1,THEMIS2,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,CDH5,TNFAIP3,TNFRSF1B,VPS35,ZBP1,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CX3CL1,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X"]
["GO:BP","response to bacterium","GO:0009617",{"v":8.20349738869829e-21,"d":"8.20E-21"},743,235,67,18117,"EDNRB,EPHA2,ADAM17,SERPINB9,SERPINE1,RPS19,NOTCH1,NOTCH2,NR1H3,AXL,PDCD4,SGMS1,C5AR1,FABP4,FCER1G,GJA1,GRN,GSTP1,HAVCR2,HCK,C3,SIRPA,SLC11A1,SNCA,PPARD,SPN,STAB1,STAP1,PRKCA,PRKD1,PTAFR,PTGFR,PTGS2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,ICAM1,IDO1,IL18,IRAK2,JAK2,LGALS9,LPL,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RBPJ,TLR1,TLR2,TLR4,CCL5,CD6,CD68,CD96,CDK19,TNFAIP3,TNFRSF1B,CEBPB,CNR2,CX3CL1,CXCL2,DROSHA"]
["GO:BP","positive regulation of metabolic process","GO:0009893",{"v":1.07531571639662E-19,"d":"1.08E-19"},3783,235,139,18117,"MECOM,EDNRB,EGFR,ELF3,EPHA2,ABCD1,ACE,ADAM17,AGER,AIM2,AKNA,APOE,APP,APPL2,SERPINB9,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PDE2A,PIK3CG,BCL6,SGMS1,C5AR1,F3,FABP4,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HGF,C3,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5B,STK39,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL1R1,IL1RAP,IL1RL1,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TGFB1,THBS1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD6,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTSC,DHX9,CX3CL1,CXCL17,DAGLB,DDX3X,DROSHA,DUOXA1,HK1"]
["GO:BP","cell population proliferation","GO:0008283",{"v":1.15622016367216e-19,"d":"1.16E-19"},2054,235,104,18117,"MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ENPP3,EPHA2,ACE,ACER3,ADAM17,AGER,AKNA,ALOX5,APOE,APP,APPL2,SERPINF1,RORA,NOTCH1,NOTCH2,NUPR1,ATM,PDCD4,PIK3CG,BCL6,C5AR1,F3,FANCA,FGFR1,FN1,GJA1,GRN,GSTP1,HAVCR2,HCK,HGF,SLAMF1,SLC11A1,CALCRL,PLA2G4A,PPARD,PPARG,SPN,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGFR,PTGS1,PTGS2,PTPN2,NDST1,NDUFS4,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,IDO1,IGF1,IL18,IL18RAP,IL2RA,IL33,JAK2,KIT,LGALS9,LIPA,LRRK2,LYN,MAPK14,RASGRP1,RBPJ,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CDH5,TNFAIP3,TNFRSF1B,CEBPB,CSF1,CSF1R,CTNNBIP1,DHX9,DICER1,CX3CL1,DAGLB"]
["GO:BP","multicellular organismal process","GO:0032501",{"v":4.97858159762355e-20,"d":"4.98E-20"},7946,235,197,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCC1,ABCD1,ABHD12,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,SCN9A,SCNN1B,SDC1,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,ATRN,AXL,PDCD4,PDE2A,PIK3CG,BCL6,BCR,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLC7A2,SLIT2,CALCRL,CAMK1D,CAMK4,PJA2,PLA2G4A,PLA2G7,PLD3,PMP22,SNAP23,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR1,TLR2,TLR4,CCR2,CD200,CD28,CD47,CD6,CD81,CD96,CDH5,TNFAIP3,TNFRSF1B,TRPV4,ULK4,VPS35,ZBP1,CEBPB,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CXCL17,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X,DROSHA,DUOXA1,HK1"]
["GO:BP","signaling","GO:0023052",{"v":1.07137277875941e-18,"d":"1.07E-18"},6810,235,183,18117,"MECOM,EDNRA,EDNRB,EGFR,ELF3,EPHA2,ABR,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,MS4A2,SCN9A,SDC1,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PDE5A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HGF,C3,SIRPA,SLAMF1,SLIT2,CALCRL,CAMK4,CASP4,PJA2,PLA2G4A,PMP22,SNAP23,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LPCAT3,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD68,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DICER1,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X"]
["GO:BP","cell communication","GO:0007154",{"v":1.61536596591465e-19,"d":"1.62E-19"},6829,235,183,18117,"MECOM,EDNRA,EDNRB,EGFR,ELF3,EPHA2,ABR,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,MS4A2,SCN9A,SDC1,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PDE5A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HGF,C3,SIRPA,SLAMF1,SLIT2,CALCRL,CAMK4,CASP4,PJA2,PLA2G4A,PMP22,SNAP23,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LPCAT3,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD68,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DICER1,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X"]
["GO:BP","regulation of leukocyte activation","GO:0002694",{"v":7.53293426768041E-19,"d":"7.53E-19"},610,235,60,18117,"ENPP3,AGER,MFHAS1,RORA,NR1H3,ATM,AXL,BCL6,FANCA,FANCD2,GRN,HAVCR2,SIRPA,CAMK4,PJA2,PLA2G4A,SNCA,SPN,STAP1,STAT5B,PRKCQ,PRKCZ,PTAFR,PTPN2,NFKBID,HMGB1,HMOX1,HSPD1,IDO1,IGF1,IL18,IL1RL1,IL2RA,IL33,ITGAM,LDLR,LGALS9,LRFN5,LRRK2,LYN,RASGRP1,TGFB1,THBS1,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,TNFAIP3,TNFRSF1B,UNC13D,CEBPB,CNR2,CTSC,CX3CL1,DROSHA"]
["GO:BP","signal transduction","GO:0007165",{"v":1.29761963456983E-17,"d":"1.30E-17"},6309,235,175,18117,"MECOM,EDNRA,EDNRB,EGFR,ELF3,EPHA2,ABR,ADAM17,ADAMTS12,AGER,AIM2,ALOX5,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,MS4A2,SDC1,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PDE5A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HGF,C3,SIRPA,SLAMF1,SLIT2,CALCRL,CAMK4,CASP4,PJA2,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS2,PTPN2,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,KIT,LGALS9,LPCAT3,LPL,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DICER1,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X"]
["GO:BP","cell migration","GO:0016477",{"v":3.78439793856849E-17,"d":"3.78E-17"},1649,235,91,18117,"EDNRB,EGFR,EPHA2,ABCC1,ACE,ADAM17,ADAMTS12,AGER,ALOX5,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RPS19,NOTCH1,OLR1,ATM,ATRN,AXL,PIK3CG,C5AR1,F3,FCER1G,FGFR1,FN1,GJA1,GRN,GSTP1,HCK,HDAC9,HGF,SIRPA,SLIT2,CAMK1D,PLA2G7,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGS2,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL16,IL1R1,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LRRK2,LYN,RARRES2,TGFB1,THBS1,TIMP1,CCL4,CCL5,CCR2,CD200,CD300A,CD47,CD81,CDH5,TNFAIP3,TRPV4,ULK4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","locomotion","GO:0040011",{"v":5.31057168735631e-18,"d":"5.31E-18"},2028,235,100,18117,"EDNRB,EGFR,EPHA2,ABCC1,ACE,ADAM17,ADAMTS12,AGER,ALOX5,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RPS19,RPS6KA5,NOTCH1,NOTCH2,OLR1,ASH1L,ATM,ATRN,AXL,PIK3CG,C5AR1,F3,FCER1G,FGFR1,FN1,FPR1,FPR3,GJA1,GRN,GSTP1,HCK,HDAC9,HGF,SIRPA,SLIT2,CAMK1D,PLA2G7,SNCA,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGS2,PTPN2,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL16,IL1R1,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LRRK2,LYN,MAPK14,RARRES2,TGFB1,THBS1,TIMP1,CCL4,CCL5,CCR2,CD200,CD300A,CD47,CD81,CDH5,TNFAIP3,TRPV4,ULK4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2,CYSLTR1"]
["GO:BP","negative regulation of inflammatory response","GO:0050728",{"v":9.19010020290123e-18,"d":"9.19E-18"},171,235,37,18117,"ENPP3,ALOX5,METRNL,MFHAS1,APOE,AOAH,SERPINF1,RORA,RPS19,NR1H3,ASH1L,GRN,GSTP1,HGF,SIRPA,CALCRL,PPARA,PPARD,PPARG,SOCS3,PSMA1,PTGIS,PTPN2,NFKB1,IGF1,IL2RA,LDLR,LPCAT3,LRFN5,CD200,CDH5,TNFAIP3,TNFRSF1B,VPS35,CNR2,CX3CL1,CXCL17"]
["GO:BP","regulation of immune response","GO:0050776",{"v":1.57357578499321e-16,"d":"1.57E-16"},996,235,72,18117,"ENPP3,AGER,AIM2,APOE,APPL2,MS4A2,SERPINB9,RPS19,RPS6KA5,NR1H3,BCL6,C5AR1,FCER1G,FPR1,FPR3,GBP5,GRN,HAVCR2,HCK,C3,SLC11A1,PLA2G4A,PPARG,SOCS3,SPN,STAP1,STAT5B,PRKCQ,PRKCZ,PSMA1,PTAFR,PTPN2,NFKB1,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,ICAM1,IDO1,IL18,IL18R1,IL18RAP,IL1R1,IL1RL1,IL2RA,IL33,ITGAM,JAK2,KIT,LGALS9,LYN,RASGRP1,RELB,TGFB1,THEMIS2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD81,CD96,TNFAIP3,TNFRSF1B,UNC13D,ZBP1,CFH,CMKLR1,DHX9"]
["GO:BP","cellular response to oxygen-containing compound","GO:1901701",{"v":9.25935596980754E-17,"d":"9.26E-17"},1227,235,78,18117,"EDNRB,EGFR,ABCC1,AGER,APP,APPL2,SCNN1B,SERPINE1,SERPINF1,RORA,NR1H3,P2RX7,ATM,AXL,PDCD4,PDE2A,PIK3CG,SGMS1,GJA1,GSTP1,HAVCR2,HCK,HDAC9,HGF,SIRPA,SLIT2,CALCRL,CASP4,SNCA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,ICAM1,IGF1,IL18,IL18RAP,IRAK2,JAK2,LDLR,LPL,LRRK2,LY86,LY96,LYN,MAPK14,RARRES2,TCIRG1,TGFB1,TLR2,TLR4,CCL5,CD6,CD68,CDK19,TNFAIP3,TNFRSF1B,VPS35,CEBPB,CSRP3,CX3CL1,CXCL2,CYBB"]
["GO:BP","negative regulation of defense response","GO:0031348",{"v":1.19165075251635e-16,"d":"1.19E-16"},246,235,41,18117,"ENPP3,ALOX5,METRNL,MFHAS1,APOE,AOAH,SERPINB9,SERPINF1,RORA,RPS19,NR1H3,ASH1L,GRN,GSTP1,HAVCR2,HGF,SIRPA,CALCRL,PPARA,PPARD,PPARG,SOCS3,PSMA1,PTGIS,PTPN2,NFKB1,IGF1,IL2RA,LDLR,LGALS9,LPCAT3,LRFN5,CD200,CD96,CDH5,TNFAIP3,TNFRSF1B,VPS35,CNR2,CX3CL1,CXCL17"]
["GO:BP","regulation of signal transduction","GO:0009966",{"v":1.19165075251635e-16,"d":"1.19E-16"},3165,235,122,18117,"MECOM,EGFR,ELF3,EPHA2,ABR,ADAM17,ADAMTS12,AGER,MFHAS1,MGLL,APOE,APP,APPL2,SERPINE1,RORA,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FANCA,FANCD2,FGFR1,FN1,FPR1,GJA1,GPRC5B,GSTP1,HAVCR2,HGF,C3,SIRPA,SLAMF1,SLIT2,CASP4,PJA2,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL1R1,IL1R2,IRAK2,JAK2,KIT,LGALS9,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,REL,RICTOR,TGM2,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD81,CDH5,TNFAIP3,TNIP1,TRPV4,UACA,ULK4,VPS35,ZBP1,CMKLR1,CSF1,CSF1R,CTNNBIP1,CTSC,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","response to lipid","GO:0033993",{"v":3.70837223855903e-15,"d":"3.71E-15"},918,235,68,18117,"EDNRB,EGFR,ADAM17,SCNN1B,SDC1,SERPINE1,SERPINF1,RORA,NOTCH1,NR1H3,ATM,AXL,PDCD4,SGMS1,C5AR1,GJA1,GPX4,GSTP1,HAVCR2,HCK,SIRPA,SLC11A1,SLIT2,SNCA,PPARA,PPARD,PPARG,STAP1,STAT3,STAT5B,PRKCA,PTAFR,PTGFR,PTGS2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,ICAM1,IDO1,IL18,IRAK2,JAK2,LDLR,LGALS9,LPL,LY86,LY96,LYN,MAPK14,MAPKAPK2,TGFB1,THBS1,TLR2,TLR4,CCL5,CD6,CD68,CD96,CDK19,TNFAIP3,TNFRSF1B,CEBPB,CNR2,CX3CL1,CXCL2,CYBB"]
["GO:BP","cytokine-mediated signaling pathway","GO:0019221",{"v":9.77701994089864e-17,"d":"9.78E-17"},810,235,64,18117,"ADAM17,AIM2,ALOX5,APPL2,SDC1,RORA,RPS6KA5,NR1H3,AXL,PDCD4,BCL6,F3,FCER1G,FN1,FPR1,GSTP1,HCK,HGF,SLIT2,CASP4,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PSMA1,PTAFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMOX1,ICAM1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,JAK2,KIT,TIMP1,CCL4,CCL5,CCR2,TNFAIP3,TNFRSF1B,ZBP1,CIITA,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL2,CYLD"]
["GO:BP","innate immune response","GO:0045087",{"v":1.03248323469327E-14,"d":"1.03E-14"},998,235,70,18117,"AGER,AIM2,MFHAS1,APOE,APP,APPL2,SERPINB9,RPS19,RPS6KA5,NR1H3,AXL,PIK3CG,FCER1G,GBP5,GRN,HAVCR2,HCK,C3,SIRPA,SLAMF1,SLC11A1,CASP4,PJA2,SNCA,PPARG,SOCS3,STAT5B,PRKD1,PSMA1,PTAFR,PTPN2,NFKB1,HMGB1,HMGB2,ICAM1,IL17RA,IL18,IL18RAP,IL1RAP,ITGAM,JAK2,LGALS9,LY86,LY96,LYN,RARRES2,RASGRP1,REL,RELB,TLR1,TLR2,TLR4,CCL4,CCL5,CD47,CD6,CD96,TNFAIP3,UNC13D,ZBP1,CFH,CIITA,CSF1,CSF1R,DHX9,CX3CL1,CYBB,CYLD,DDX3X,HK1"]
["GO:BP","immune effector process","GO:0002252",{"v":1.05401646764232e-14,"d":"1.05E-14"},1309,235,79,18117,"ENPP3,ACE,ADAM17,AGER,AIM2,ALOX5,APP,APPL2,SERPINB9,RORA,RPS19,NOTCH2,OLR1,P2RX1,PIK3CG,BCL6,C5AR1,FCER1G,FPR1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,C3,SIRPA,SLAMF1,SLC11A1,SNAP23,SPN,STAP1,STAT3,STAT5B,PRCP,PRKCZ,PTAFR,PTGDR,NFKB1,NFKBID,HMGB1,HMOX1,HSPD1,HYAL2,ICAM1,IL18,IL18R1,IL18RAP,IL1R1,IL2RA,IL33,ITGAM,KIT,LGALS9,LYN,MAPK14,RASGRP1,RELB,TCIRG1,TLR2,TLR4,CCR2,CD28,CD300A,CD47,CD68,CD81,CD96,TNFAIP3,TNFRSF1B,UNC13D,ZBP1,CFH,CTSC,CTSS,DHX9,CYBB,DDX3X,DNASE1,HK1"]
["GO:BP","cell motility","GO:0048870",{"v":1.66894672440443e-14,"d":"1.67E-14"},1828,235,92,18117,"EDNRB,EGFR,EPHA2,ABCC1,ACE,ADAM17,ADAMTS12,AGER,ALOX5,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RPS19,NOTCH1,OLR1,ASH1L,ATM,ATRN,AXL,PIK3CG,C5AR1,F3,FCER1G,FGFR1,FN1,GJA1,GRN,GSTP1,HCK,HDAC9,HGF,SIRPA,SLIT2,CAMK1D,PLA2G7,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGS2,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL16,IL1R1,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LRRK2,LYN,RARRES2,TGFB1,THBS1,TIMP1,CCL4,CCL5,CCR2,CD200,CD300A,CD47,CD81,CDH5,TNFAIP3,TRPV4,ULK4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","localization of cell","GO:0051674",{"v":1.66894672440443e-14,"d":"1.67E-14"},1828,235,92,18117,"EDNRB,EGFR,EPHA2,ABCC1,ACE,ADAM17,ADAMTS12,AGER,ALOX5,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RPS19,NOTCH1,OLR1,ASH1L,ATM,ATRN,AXL,PIK3CG,C5AR1,F3,FCER1G,FGFR1,FN1,GJA1,GRN,GSTP1,HCK,HDAC9,HGF,SIRPA,SLIT2,CAMK1D,PLA2G7,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGS2,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL16,IL1R1,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LRRK2,LYN,RARRES2,TGFB1,THBS1,TIMP1,CCL4,CCL5,CCR2,CD200,CD300A,CD47,CD81,CDH5,TNFAIP3,TRPV4,ULK4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","positive regulation of macromolecule metabolic process","GO:0010604",{"v":2.52003195606973e-14,"d":"2.52E-14"},3483,235,126,18117,"MECOM,EDNRB,EGFR,ELF3,ACE,ADAM17,AGER,AIM2,AKNA,APOE,APP,SERPINB9,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,PDE2A,PIK3CG,BCL6,SGMS1,C5AR1,F3,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPRC5B,GRN,HAVCR2,HGF,C3,SLC11A1,CAMK4,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5B,STK39,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGFR,PTGS2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL1R1,IL1RAP,IL1RL1,IL33,IRAK2,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TGFB1,THBS1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD6,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,VPS35,ZBP1,CEBPB,CIITA,CSF1,CSF1R,CSRP3,CTSC,DHX9,CX3CL1,CXCL17,DDX3X,DROSHA,HK1"]
["GO:BP","regulation of cell communication","GO:0010646",{"v":2.87680659201559e-14,"d":"2.88E-14"},3543,235,127,18117,"MECOM,EGFR,ELF3,EPHA2,ABR,ADAM17,ADAMTS12,AGER,ALOX5,MFHAS1,MGLL,APOE,APP,APPL2,SERPINE1,RORA,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FANCA,FANCD2,FGFR1,FN1,FPR1,GJA1,GPRC5B,GSTP1,HAVCR2,HGF,C3,SIRPA,SLAMF1,SLIT2,CASP4,PJA2,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,PXK,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL1R1,IL1R2,IRAK2,JAK2,KIT,LGALS9,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,REL,RICTOR,TCIRG1,TGM2,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD81,CDH5,TNFAIP3,TNIP1,TRPV4,UACA,ULK4,VPS35,ZBP1,CMKLR1,CNR2,CSF1,CSF1R,CTNNBIP1,CTSC,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","positive regulation of signal transduction","GO:0009967",{"v":3.02381201364413e-15,"d":"3.02E-15"},1598,235,86,18117,"EGFR,ELF3,ADAM17,AGER,MFHAS1,APOE,APP,APPL2,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,AXL,PDCD4,PIK3AP1,PIK3CG,C5AR1,F3,FGFR1,FN1,FPR1,GJA1,GPRC5B,HAVCR2,HGF,C3,SLAMF1,CASP4,PJA2,PPARD,STAP1,STAT3,STK39,PRKCA,PRKCZ,PRKD1,PSMA1,PTGIS,PTPN2,NDST1,NFKB1,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL1R1,IRAK2,JAK2,KIT,LGALS9,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,REL,RICTOR,TGM2,THBS1,TLR1,TLR2,TLR4,CCL4,CCL5,CD28,CD300A,CD81,CDH5,TNFAIP3,TRPV4,VPS35,ZBP1,CSF1,CSF1R,CTSC,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","regulation of cell population proliferation","GO:0042127",{"v":5.54790692916268e-15,"d":"5.55E-15"},1774,235,90,18117,"EDNRB,EGFR,EIF2AK1,ENPP3,ACE,ACER3,ADAM17,AGER,ALOX5,APOE,APP,APPL2,SERPINF1,NOTCH1,NOTCH2,NUPR1,ATM,PDCD4,BCL6,C5AR1,F3,FANCA,FGFR1,FN1,GJA1,GRN,GSTP1,HAVCR2,HCK,SLAMF1,CALCRL,PLA2G4A,PPARD,PPARG,SPN,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGFR,PTGS1,PTGS2,PTPN2,NDUFS4,NFKBIA,HMGB1,HMGB2,HMOX1,IDO1,IGF1,IL18,IL2RA,IL33,JAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,RBPJ,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CDH5,TNFAIP3,TNFRSF1B,CEBPB,CSF1,CSF1R,CTNNBIP1,DHX9,DICER1,CX3CL1"]
["GO:BP","regulation of signaling","GO:0023051",{"v":7.59638595330844e-15,"d":"7.60E-15"},3578,235,127,18117,"MECOM,EGFR,ELF3,EPHA2,ABR,ADAM17,ADAMTS12,AGER,ALOX5,MFHAS1,MGLL,APOE,APP,APPL2,SERPINE1,RORA,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FANCA,FANCD2,FGFR1,FN1,FPR1,GJA1,GPRC5B,GSTP1,HAVCR2,HGF,C3,SIRPA,SLAMF1,SLIT2,CASP4,PJA2,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,PXK,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL1R1,IL1R2,IRAK2,JAK2,KIT,LGALS9,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,REL,RICTOR,TCIRG1,TGM2,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD47,CD81,CDH5,TNFAIP3,TNIP1,TRPV4,UACA,ULK4,VPS35,ZBP1,CMKLR1,CNR2,CSF1,CSF1R,CTNNBIP1,CTSC,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","leukocyte migration","GO:0050900",{"v":8.59537114225247e-15,"d":"8.60E-15"},511,235,52,18117,"EDNRB,ADAM17,AGER,ALOX5,APP,SDC1,SERPINE1,RPS19,OLR1,PIK3CG,C5AR1,FCER1G,FN1,HCK,SIRPA,SLIT2,CAMK1D,PLA2G7,SPN,STAP1,STAT5B,STK39,PTAFR,HMGB1,HMOX1,ICAM1,IL16,IL1R1,IL33,ITGAM,JAM3,KIT,LGALS9,LYN,RARRES2,TGFB1,THBS1,CCL4,CCL5,CCR2,CD200,CD300A,CD47,CD81,TRPV4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","macrophage activation","GO:0042116",{"v":1.05361979442469E-13,"d":"1.05E-13"},110,235,30,18117,"AGER,MFHAS1,APP,RORA,NR1H3,ATM,C5AR1,GRN,HAVCR2,SLC11A1,PJA2,PLA2G4A,SNCA,STAP1,HMGB1,HSPD1,IL1RL1,IL33,ITGAM,JAK2,LDLR,LRFN5,LRRK2,THBS1,TLR1,TLR2,TLR4,CD200,CTSC,CX3CL1"]
["GO:BP","cell death","GO:0008219",{"v":2.22545975499699E-13,"d":"2.23E-13"},2292,235,101,18117,"MECOM,EDNRB,EGFR,EPHA2,ABR,ACER3,ADAM17,AIM2,APOE,APP,SERPINB9,SERPINE1,SERPINF1,NOTCH1,NOTCH2,NUPR1,OLR1,P2RX1,P2RX7,ATM,AXL,PARP4,PDCD4,PIK3CG,BCL6,SGMS1,C5AR1,FGFR1,GJA1,GPX4,GRN,GSTP1,HCK,HGF,SLIT2,CAMK1D,CASP4,PMP22,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL2RA,IL33,ITGAM,JAK2,KIT,LGALS9,LRRK2,LY96,LYN,MAPK14,REL,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD200,CD28,CDH5,CDK19,TNFAIP3,TNFRSF1B,UACA,VPS35,ZBP1,CEBPB,CSF1,CSF1R,CTSC,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DNASE1"]
["GO:BP","negative regulation of response to external stimulus","GO:0032102",{"v":3.00683100339983e-14,"d":"3.01E-14"},406,235,47,18117,"ENPP3,ALOX5,METRNL,MFHAS1,APOE,AOAH,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,NOTCH1,NR1H3,ASH1L,GJA1,GRN,GSTP1,HAVCR2,HGF,SIRPA,SLIT2,CALCRL,PPARA,PPARD,PPARG,SOCS3,STAP1,PSMA1,PTGIS,PTPN2,NFKB1,IGF1,IL2RA,LDLR,LGALS9,LPCAT3,LRFN5,THBS1,CD200,CD96,CDH5,TNFAIP3,TNFRSF1B,VPS35,CNR2,CX3CL1,CXCL17"]
["GO:BP","positive regulation of cell communication","GO:0010647",{"v":3.45712977138715E-13,"d":"3.46E-13"},1777,235,89,18117,"EGFR,ELF3,ADAM17,AGER,MFHAS1,APOE,APP,APPL2,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,AXL,PDCD4,PIK3AP1,PIK3CG,C5AR1,F3,FGFR1,FN1,FPR1,GJA1,GPRC5B,HAVCR2,HGF,C3,SLAMF1,CASP4,PJA2,SNCA,PPARD,STAP1,STAT3,STK39,PRKCA,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NDST1,NFKB1,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL1R1,IRAK2,JAK2,KIT,LGALS9,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,REL,RICTOR,TGM2,THBS1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD81,CDH5,TNFAIP3,TRPV4,VPS35,ZBP1,CSF1,CSF1R,CTSC,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","positive regulation of signaling","GO:0023056",{"v":4.16635331531192e-14,"d":"4.17E-14"},1782,235,89,18117,"EGFR,ELF3,ADAM17,AGER,MFHAS1,APOE,APP,APPL2,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,AXL,PDCD4,PIK3AP1,PIK3CG,C5AR1,F3,FGFR1,FN1,FPR1,GJA1,GPRC5B,HAVCR2,HGF,C3,SLAMF1,CASP4,PJA2,SNCA,PPARD,STAP1,STAT3,STK39,PRKCA,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NDST1,NFKB1,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL1R1,IRAK2,JAK2,KIT,LGALS9,LRRK2,LY86,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,REL,RICTOR,TGM2,THBS1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD81,CDH5,TNFAIP3,TRPV4,VPS35,ZBP1,CSF1,CSF1R,CTSC,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","cellular response to molecule of bacterial origin","GO:0071219",{"v":4.16635331531192e-14,"d":"4.17E-14"},214,235,37,18117,"EDNRB,SERPINE1,NR1H3,AXL,PDCD4,SGMS1,GSTP1,HAVCR2,HCK,SIRPA,PPARD,STAP1,PRKCA,PTAFR,NFKB1,NFKBIA,HMGB1,HMGB2,ICAM1,IL18,IRAK2,LY86,LY96,LYN,MAPK14,TLR1,TLR2,TLR4,CCL5,CD6,CD68,CDK19,TNFAIP3,TNFRSF1B,CEBPB,CX3CL1,CXCL2"]
["GO:BP","cellular response to lipopolysaccharide","GO:0071222",{"v":6.08920877779751e-14,"d":"6.09E-14"},200,235,36,18117,"EDNRB,SERPINE1,NR1H3,AXL,PDCD4,SGMS1,GSTP1,HAVCR2,HCK,SIRPA,PPARD,STAP1,PRKCA,PTAFR,NFKB1,NFKBIA,HMGB1,HMGB2,ICAM1,IL18,IRAK2,LY86,LY96,LYN,MAPK14,TLR2,TLR4,CCL5,CD6,CD68,CDK19,TNFAIP3,TNFRSF1B,CEBPB,CX3CL1,CXCL2"]
["GO:BP","regulation of locomotion","GO:0040012",{"v":6.29507027442704E-15,"d":"6.30E-15"},1104,235,71,18117,"EGFR,EPHA2,ACE,ADAM17,AGER,APOE,APP,APPL2,SERPINE1,SERPINF1,NOTCH1,ATM,PIK3CG,C5AR1,F3,FGFR1,FN1,GJA1,GRN,GSTP1,HDAC9,HGF,SLIT2,CAMK1D,PLA2G7,SNCA,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STK39,PRCP,PRKCA,PRKD1,PTAFR,PTGS2,PTPN2,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL16,IL1R1,IL33,JAK2,JAM3,KIT,LGALS9,LRRK2,LYN,RARRES2,TGFB1,THBS1,TIMP1,CCL4,CCL5,CCR2,CD200,CD300A,CD81,CDH5,TRPV4,ULK4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","regulation of gene expression","GO:0010468",{"v":8.77514908691003e-14,"d":"8.78E-14"},5196,235,152,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ADAM17,AGER,AIM2,AKNA,ALOX5,APOE,APP,APPL2,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,BCL6,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FN1,GBP5,GJA1,GPRC5B,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,CAMK1D,CAMK4,PLD3,SNCA,PPARA,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL33,IRAK2,ITGB6,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,THBS1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD47,CD6,CD81,CD96,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,DROSHA,HK1"]
["GO:BP","negative regulation of response to stimulus","GO:0048585",{"v":1.6927995864365E-13,"d":"1.69E-13"},1733,235,87,18117,"MECOM,EGFR,ENPP3,EPHA2,ADAM17,ADAMTS12,ALOX5,METRNL,MFHAS1,APOE,APPL2,AOAH,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,NOTCH1,NR1H3,P2RX7,ASH1L,ATM,PDCD4,PDE2A,BCL6,GJA1,GRN,GSTP1,HAVCR2,HGF,SIRPA,SLAMF1,SLIT2,CALCRL,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,PRKCQ,PRKCZ,PSMA1,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL1R2,IL1RL1,IL2RA,IL33,LDLR,LGALS9,LPCAT3,LPL,LRFN5,LRRK2,LY96,LYN,MAPK14,TGFB1,THBS1,TLR4,CCL5,CCR2,CD200,CD300A,CD47,CD96,CDH5,TNFAIP3,TNFRSF1B,TNIP1,UACA,VPS35,CNR2,CTNNBIP1,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","regulation of cell migration","GO:0030334",{"v":3.6020418927471e-13,"d":"3.60E-13"},999,235,67,18117,"EGFR,EPHA2,ACE,ADAM17,AGER,APOE,APP,APPL2,SERPINE1,SERPINF1,NOTCH1,ATM,PIK3CG,C5AR1,F3,FGFR1,FN1,GJA1,GRN,GSTP1,HDAC9,HGF,SLIT2,CAMK1D,PLA2G7,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STK39,PRCP,PRKCA,PRKD1,PTAFR,PTGS2,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL1R1,IL33,JAK2,JAM3,KIT,LGALS9,LYN,RARRES2,TGFB1,THBS1,TIMP1,CCL4,CCL5,CCR2,CD200,CD300A,CD81,CDH5,TRPV4,ULK4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","cell activation involved in immune response","GO:0002263",{"v":4.42416489393037e-12,"d":"4.42E-12"},721,235,58,18117,"ENPP3,ALOX5,APP,RORA,NOTCH2,OLR1,P2RX1,PIK3CG,BCL6,C5AR1,FCER1G,FPR1,GRN,GSTP1,HAVCR2,C3,SIRPA,SLAMF1,SLC11A1,SNAP23,SPN,STAT3,PRCP,PRKCZ,PTAFR,PTGDR,NFKB1,NFKBID,HMGB1,HMOX1,HSPD1,ICAM1,IL18,IL18R1,IL33,ITGAM,KIT,LGALS9,LYN,MAPK14,RASGRP1,RELB,TCIRG1,TLR2,TLR4,CCR2,CD28,CD300A,CD47,CD68,CD81,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X,DNASE1"]
["GO:BP","cell chemotaxis","GO:0060326",{"v":1.2033256711157E-11,"d":"1.20E-11"},310,235,41,18117,"EDNRB,EPHA2,ABCC1,ADAM17,ALOX5,SERPINE1,RPS19,NOTCH1,PIK3CG,C5AR1,FCER1G,FGFR1,GSTP1,HGF,SLIT2,CAMK1D,PLA2G7,STAP1,STK39,PRKCQ,PRKD1,HMGB1,HMGB2,IL16,JAM3,KIT,LGALS9,LYN,RARRES2,THBS1,CCL4,CCL5,CCR2,TRPV4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","cellular response to biotic stimulus","GO:0071216",{"v":2.09749545061876e-11,"d":"2.10E-11"},238,235,37,18117,"EDNRB,SERPINE1,NR1H3,AXL,PDCD4,SGMS1,GSTP1,HAVCR2,HCK,SIRPA,PPARD,STAP1,PRKCA,PTAFR,NFKB1,NFKBIA,HMGB1,HMGB2,ICAM1,IL18,IRAK2,LY86,LY96,LYN,MAPK14,TLR1,TLR2,TLR4,CCL5,CD6,CD68,CDK19,TNFAIP3,TNFRSF1B,CEBPB,CX3CL1,CXCL2"]
["GO:BP","regulation of localization","GO:0032879",{"v":2.3027997854849e-12,"d":"2.30E-12"},2872,235,110,18117,"EDNRA,EDNRB,EGFR,EPHA2,ACE,ADAM17,AGER,ALOX5,MFHAS1,APOE,APP,APPL2,SCN9A,SDC1,SERPINE1,SERPINF1,RPS19,NOTCH1,NR1H3,P2RX1,P2RX7,ATM,AXL,PIK3CG,BCL6,C5AR1,F3,FCER1G,FGFR1,FN1,GJA1,GRN,GSTP1,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STK39,PRCP,PRKCA,PRKCZ,PRKD1,PTAFR,PTGS2,PTPN2,PXK,NFKB1,NFKBIA,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL16,IL1R1,IL33,ITGAM,JAK2,JAM3,KIT,LGALS9,LPCAT3,LPL,LRRK2,LYN,MAPK14,RARRES2,TCIRG1,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD300A,CD47,CD81,CDH5,TNFRSF1B,TRPV4,ULK4,UNC13D,VPS35,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,CTSS,DHX9,CX3CL1,CXCL17,CYBB"]
["GO:BP","leukocyte activation involved in immune response","GO:0002366",{"v":2.68049817123496E-11,"d":"2.68E-11"},717,235,57,18117,"ENPP3,ALOX5,RORA,NOTCH2,OLR1,P2RX1,PIK3CG,BCL6,C5AR1,FCER1G,FPR1,GRN,GSTP1,HAVCR2,C3,SIRPA,SLAMF1,SLC11A1,SNAP23,SPN,STAT3,PRCP,PRKCZ,PTAFR,PTGDR,NFKB1,NFKBID,HMGB1,HMOX1,HSPD1,ICAM1,IL18,IL18R1,IL33,ITGAM,KIT,LGALS9,LYN,MAPK14,RASGRP1,RELB,TCIRG1,TLR2,TLR4,CCR2,CD28,CD300A,CD47,CD68,CD81,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X,DNASE1"]
["GO:BP","regulation of leukocyte migration","GO:0002685",{"v":7.21587348763542e-12,"d":"7.22E-12"},211,235,35,18117,"ADAM17,AGER,APP,SERPINE1,C5AR1,SLIT2,CAMK1D,PLA2G7,SPN,STAP1,STK39,PTAFR,HMGB1,HMOX1,ICAM1,IL1R1,IL33,JAM3,LGALS9,LYN,RARRES2,TGFB1,THBS1,CCL4,CCL5,CCR2,CD200,CD300A,CD81,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","regulation of macromolecule metabolic process","GO:0060255",{"v":7.35717894469491e-12,"d":"7.36E-12"},6603,235,169,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ADAM17,AGER,AIM2,AKNA,ALOX5,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PIK3CG,BCL6,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CAMK1D,CAMK4,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL33,IRAK2,ITGB6,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LXN,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CD96,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,DROSHA,HK1"]
["GO:BP","regulation of cell motility","GO:2000145",{"v":1.16559875307334e-10,"d":"1.17E-10"},1061,235,67,18117,"EGFR,EPHA2,ACE,ADAM17,AGER,APOE,APP,APPL2,SERPINE1,SERPINF1,NOTCH1,ATM,PIK3CG,C5AR1,F3,FGFR1,FN1,GJA1,GRN,GSTP1,HDAC9,HGF,SLIT2,CAMK1D,PLA2G7,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STK39,PRCP,PRKCA,PRKD1,PTAFR,PTGS2,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL1R1,IL33,JAK2,JAM3,KIT,LGALS9,LYN,RARRES2,TGFB1,THBS1,TIMP1,CCL4,CCL5,CCR2,CD200,CD300A,CD81,CDH5,TRPV4,ULK4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","chemotaxis","GO:0006935",{"v":1.37822740463865E-10,"d":"1.38E-10"},653,235,54,18117,"EDNRB,EPHA2,ABCC1,ADAM17,AGER,ALOX5,APP,SERPINE1,RPS19,RPS6KA5,NOTCH1,NOTCH2,PIK3CG,C5AR1,F3,FCER1G,FGFR1,FPR1,FPR3,GSTP1,HGF,SLIT2,CAMK1D,PLA2G7,SPN,STAP1,STK39,PRKCA,PRKCQ,PRKD1,PTAFR,PTPN2,HMGB1,HMGB2,IL16,JAM3,KIT,LGALS9,LYN,MAPK14,RARRES2,THBS1,CCL4,CCL5,CCR2,TRPV4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2,CYSLTR1"]
["GO:BP","taxis","GO:0042330",{"v":1.71194549637495e-11,"d":"1.71E-11"},656,235,54,18117,"EDNRB,EPHA2,ABCC1,ADAM17,AGER,ALOX5,APP,SERPINE1,RPS19,RPS6KA5,NOTCH1,NOTCH2,PIK3CG,C5AR1,F3,FCER1G,FGFR1,FPR1,FPR3,GSTP1,HGF,SLIT2,CAMK1D,PLA2G7,SPN,STAP1,STK39,PRKCA,PRKCQ,PRKD1,PTAFR,PTPN2,HMGB1,HMGB2,IL16,JAM3,KIT,LGALS9,LYN,MAPK14,RARRES2,THBS1,CCL4,CCL5,CCR2,TRPV4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2,CYSLTR1"]
["GO:BP","regulation of cellular component movement","GO:0051270",{"v":1.90257829478786E-10,"d":"1.90E-10"},1141,235,69,18117,"EGFR,EPHA2,ACE,ADAM17,AGER,APOE,APP,APPL2,SERPINE1,SERPINF1,RPS19,NOTCH1,ATM,PIK3CG,BCL6,C5AR1,F3,FGFR1,FN1,GJA1,GRN,GSTP1,HDAC9,HGF,SLIT2,CAMK1D,PLA2G7,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STK39,PRCP,PRKCA,PRKD1,PTAFR,PTGS2,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL1R1,IL33,JAK2,JAM3,KIT,LGALS9,LYN,RARRES2,TGFB1,THBS1,TIMP1,CCL4,CCL5,CCR2,CD200,CD300A,CD81,CDH5,TRPV4,ULK4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","programmed cell death","GO:0012501",{"v":4.63879960184255e-10,"d":"4.64E-10"},2143,235,93,18117,"MECOM,EDNRB,EGFR,EPHA2,ABR,ACER3,ADAM17,AIM2,APOE,APP,SERPINB9,SERPINE1,NOTCH1,NOTCH2,NUPR1,P2RX1,P2RX7,ATM,AXL,PDCD4,PIK3CG,BCL6,SGMS1,C5AR1,FGFR1,GJA1,GPX4,GRN,GSTP1,HCK,HGF,SLIT2,CAMK1D,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL2RA,IL33,ITGAM,JAK2,KIT,LGALS9,LRRK2,LY96,LYN,MAPK14,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD28,CDH5,CDK19,TNFAIP3,TNFRSF1B,UACA,VPS35,ZBP1,CEBPB,CSF1R,CTSC,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DNASE1"]
["GO:BP","negative regulation of multicellular organismal process","GO:0051241",{"v":5.02043847628588e-11,"d":"5.02E-11"},1160,235,69,18117,"EGFR,EPHA2,ABCD1,ADAM17,ADAMTS12,AGER,ALOX5,APOE,APPL2,SERPINE1,SERPINF1,RPS19,RPS6KA5,NOTCH1,NR1H3,P2RX7,AXL,PDCD4,PIK3CG,BCL6,FN1,GJA1,GRN,GSTP1,HAVCR2,HDAC9,HGF,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,PPARA,PPARG,STAB1,STK39,PTGS2,PTPN2,NFKB1,HMGB1,HMOX1,IDO1,IGF1,IL18R1,IL1R2,IL1RL1,IL33,JAK2,LDLR,LGALS9,LYN,RBPJ,REL,RELB,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCR2,CD200,CD96,TNFAIP3,TNFRSF1B,CMKLR1,CTSC,DICER1,CX3CL1,CYLD"]
["GO:BP","immune system development","GO:0002520",{"v":5.19206988828416e-11,"d":"5.19E-11"},1020,235,65,18117,"MECOM,EIF2AK1,EPHA2,ACE,ADAM17,AGER,MFHAS1,APP,RORA,RPS19,NOTCH1,NOTCH2,ATM,AXL,PDE2A,BCL6,FANCA,FANCD2,FCER1G,HAVCR2,HDAC9,CAMK4,PPARG,SPN,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PSMA1,PTPN2,NFKBIA,NFKBID,HMGB1,HMGB2,HSPD1,HYAL2,IDO1,IL18,IL18R1,IL2RA,ITGB6,JAK2,JAM3,KIT,LGALS9,LYN,MAPK14,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCR2,CD28,CD81,TNFAIP3,CEBPB,CSF1,CSF1R,CTNNBIP1,DROSHA"]
["GO:BP","regulation of intracellular signal transduction","GO:1902531",{"v":6.61994143684331e-11,"d":"6.62E-11"},1842,235,86,18117,"MECOM,EGFR,EPHA2,ABR,AGER,MFHAS1,APOE,APP,RORA,NOTCH1,NOTCH2,NUPR1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FGFR1,FN1,FPR1,GJA1,GPRC5B,GSTP1,HAVCR2,HGF,SIRPA,SLAMF1,SLIT2,PJA2,PPARA,PPARD,STK39,PRKCA,PRKCZ,PRKD1,PTGS2,PTPN2,NDST1,NFKBIA,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IRAK2,JAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,REL,RICTOR,TGM2,THBS1,TLR2,TLR4,CCL4,CCL5,CD28,CD300A,CD81,TNFAIP3,TNIP1,TRPV4,UACA,ULK4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","regulation of cell death","GO:0010941",{"v":8.30619278728668e-11,"d":"8.31E-11"},1720,235,83,18117,"MECOM,EDNRB,EGFR,ABR,ACER3,ADAM17,APOE,SERPINB9,SERPINE1,SERPINF1,NOTCH1,NOTCH2,NUPR1,ATM,AXL,PDCD4,PIK3CG,BCL6,SGMS1,C5AR1,FGFR1,GJA1,GPX4,GRN,GSTP1,HCK,HGF,SLIT2,CAMK1D,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,ITGAM,JAK2,KIT,LGALS9,LRRK2,LYN,REL,TGFB1,TGM2,THBS1,TIMP1,TLR4,CCL5,CD200,CD28,CDH5,CDK19,TNFAIP3,TNFRSF1B,VPS35,ZBP1,CEBPB,CSF1,CSF1R,CTSC,CX3CL1,CYLD,DDX3X"]
["GO:BP","movement of cell or subcellular component","GO:0006928",{"v":1.18379379521873e-09,"d":"1.18E-09"},2311,235,96,18117,"EDNRB,EGFR,EPHA2,ABCC1,ACE,ADAM17,ADAMTS12,AGER,ALOX5,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RPS19,RPS6KA5,NOTCH1,NOTCH2,OLR1,ASH1L,ATM,ATRN,AXL,PIK3CG,BCL6,C5AR1,F3,FCER1G,FGFR1,FN1,GJA1,GRN,GSTP1,HCK,HDAC9,HGF,SIRPA,SLIT2,CAMK1D,PLA2G7,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGS2,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL16,IL1R1,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LRRK2,LYN,RARRES2,RASGRP1,TGFB1,THBS1,TIMP1,CCL4,CCL5,CCR2,CD200,CD300A,CD47,CD81,CDH5,TNFAIP3,TRPV4,ULK4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","apoptotic process","GO:0006915",{"v":1.18836762166833e-09,"d":"1.19E-09"},1990,235,89,18117,"MECOM,EDNRB,EGFR,EPHA2,ABR,ADAM17,AIM2,APOE,APP,SERPINB9,SERPINE1,NOTCH1,NOTCH2,NUPR1,P2RX1,P2RX7,ATM,AXL,PDCD4,PIK3CG,BCL6,SGMS1,C5AR1,FGFR1,GJA1,GRN,GSTP1,HCK,HGF,SLIT2,CAMK1D,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL2RA,IL33,ITGAM,JAK2,LGALS9,LRRK2,LY96,LYN,MAPK14,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD28,CDH5,CDK19,TNFAIP3,TNFRSF1B,UACA,VPS35,ZBP1,CEBPB,CSF1R,CTSC,DICER1,CX3CL1,CYLD,DDX3X,DNASE1"]
["GO:BP","regulation of developmental process","GO:0050793",{"v":1.31750995819101E-11,"d":"1.32E-11"},2605,235,102,18117,"EDNRB,EGFR,EPHA2,ADAMTS12,AGER,ALOX5,METRNL,APOE,APP,APPL2,SERPINE1,SERPINF1,RORA,RPS19,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ATRN,AXL,PDCD4,BCL6,C5AR1,F3,FANCA,FANCD2,FGFR1,FN1,GJA1,GPRC5B,GRN,HCK,HDAC9,HGF,C3,SLIT2,CAMK1D,CAMK4,PPARA,PPARD,PPARG,SOCS3,STAB1,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,ICAM1,IGF1,IL18,IL1RAP,IL2RA,JAK2,KIT,LDLR,LGALS9,LPL,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,RBPJ,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCR2,CD28,CDH5,TNFAIP3,TNFRSF1B,TRPV4,UNC13D,VPS35,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DICER1,CX3CL1,CYBB,DROSHA,DUOXA1"]
["GO:BP","regulation of metabolic process","GO:0019222",{"v":1.56099485181303e-09,"d":"1.56E-09"},7148,235,174,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ADAM17,AGER,AIM2,AKNA,ALOX5,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PIK3CG,BCL6,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CAMK1D,CAMK4,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL33,IRAK2,ITGAM,ITGB6,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LXN,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CD96,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DAGLB,DDX3X,DROSHA,DUOXA1,HK1"]
["GO:BP","intracellular signal transduction","GO:0035556",{"v":2.16108155703775E-10,"d":"2.16E-10"},2772,235,105,18117,"MECOM,EDNRB,EGFR,EPHA2,ABR,AGER,MFHAS1,APOE,APP,RORA,RPS6KA5,NOTCH1,NOTCH2,NUPR1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FGFR1,FN1,FPR1,GJA1,GPRC5B,GSTP1,HAVCR2,HGF,SIRPA,SLAMF1,SLIT2,CAMK4,CASP4,PJA2,PPARA,PPARD,SOCS3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGS2,PTPN2,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL2RA,IRAK2,JAK2,KIT,LGALS9,LRRK2,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,REL,RELB,RICTOR,TGM2,THBS1,TLR2,TLR4,CCL4,CCL5,CCR2,CD28,CD300A,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,DICER1,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","system development","GO:0048731",{"v":3.82270817940592E-10,"d":"3.82E-10"},5052,235,144,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ACER3,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,MFHAS1,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NUPR1,P2RX7,ASH1L,ATM,ATRN,AXL,PDCD4,PDE2A,PIK3CG,BCL6,BCR,C5AR1,F3,FANCA,FANCD2,FCER1G,FGFR1,FN1,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HDAC9,HGF,C3,SLIT2,CALCRL,CAMK1D,CAMK4,PMP22,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NDST1,NDUFS4,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL1RAP,IL2RA,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LIPA,LRFN5,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,RELB,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCR2,CD28,CD81,CDH5,TNFAIP3,TNFRSF1B,TRPV4,ULK4,VPS35,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DICER1,CX3CL1,CXCL17,CYBB,DAGLB,DROSHA,DUOXA1"]
["GO:BP","homeostatic process","GO:0042592",{"v":4.17483767309138e-10,"d":"4.17E-10"},1981,235,88,18117,"EDNRA,EDNRB,EGFR,EIF2AK1,ABCD1,ADAM17,AGER,ALOX5,METRNL,MFHAS1,APOE,APP,APPL2,SCNN1B,SERPINF1,RORA,RPS19,NOTCH1,NR1H3,P2RX1,P2RX7,ATM,AXL,PIK3CG,BCL6,C5AR1,FABP4,FPR1,FPR3,GJA1,GRN,GSTP1,HDAC9,SLC11A1,SNCA,PPARD,PPARG,STAT3,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKD1,PTGDR,PTGFR,PTGS2,PTPN2,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IL18,IL18R1,IL2RA,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRRK2,LYN,MAPK14,RBPJ,TCIRG1,TGFB1,TGM2,TLR4,CCL5,CCR2,CDH5,TNFAIP3,TRPV4,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,CX3CL1,CYBB,CYSLTR1,DDX3X,HK1"]
["GO:BP","regulation of cell differentiation","GO:0045595",{"v":4.35192181191703e-10,"d":"4.35E-10"},1679,235,81,18117,"EDNRB,EGFR,ADAMTS12,AGER,ALOX5,METRNL,APP,APPL2,SERPINE1,SERPINF1,RORA,RPS19,NOTCH1,NOTCH2,NR1H3,AXL,PDCD4,BCL6,FANCA,FANCD2,FGFR1,FN1,GJA1,GPRC5B,GRN,HDAC9,HGF,SLIT2,CAMK4,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGS2,PTPN2,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,IGF1,IL18,IL2RA,JAK2,KIT,LDLR,LGALS9,LPL,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,RBPJ,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCR2,CD28,CDH5,TNFRSF1B,TRPV4,UNC13D,CEBPB,CMKLR1,CSF1,CSRP3,CTNNBIP1,DICER1,CX3CL1,DROSHA,DUOXA1"]
["GO:BP","regulation of molecular function","GO:0065009",{"v":5.00440868152299e-10,"d":"5.00E-10"},3221,235,113,18117,"MCPH1,EDNRA,EDNRB,EGFR,EPHA2,ABR,ACE,ADAM17,AGER,AIM2,ALOX5AP,APOE,APP,SERPINB9,SERPINE1,SERPINF1,RPS6KA5,NOTCH1,NR1H3,NUPR1,P2RX1,AXL,PARP4,PDCD4,PIK3CG,BCL6,BCR,C5AR1,F3,FABP4,FANCA,FANCD2,FGFR1,FN1,FPR1,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,SNCA,PPARA,PPARG,SOCS3,STAP1,STAT3,STK39,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGIS,PTGS2,PTPN2,PXK,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IRAK2,ITGAM,JAK2,KIT,LGALS9,LPL,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD300A,CD81,TNFAIP3,UACA,CMKLR1,CNR2,CSF1,CSF1R,CTNNBIP1,CTSS,DHX9,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","myeloid leukocyte migration","GO:0097529",{"v":5.10190722485049e-10,"d":"5.10E-10"},221,235,34,18117,"EDNRB,AGER,SERPINE1,RPS19,PIK3CG,C5AR1,FCER1G,SIRPA,SLIT2,CAMK1D,PLA2G7,STAP1,STAT5B,HMGB1,IL1R1,JAM3,KIT,LYN,RARRES2,THBS1,CCL4,CCL5,CCR2,CD200,CD300A,CD47,CD81,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","hemopoiesis","GO:0030097",{"v":5.44744634650877e-10,"d":"5.45E-10"},928,235,61,18117,"MECOM,EIF2AK1,EPHA2,ACE,ADAM17,AGER,MFHAS1,APP,RORA,RPS19,NOTCH1,NOTCH2,ATM,AXL,PDE2A,BCL6,FANCA,FANCD2,FCER1G,HDAC9,CAMK4,PPARG,SPN,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PSMA1,PTPN2,NFKBIA,NFKBID,HMGB1,HMGB2,HYAL2,IL18,IL18R1,IL2RA,ITGB6,JAK2,JAM3,KIT,LGALS9,LYN,MAPK14,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCR2,CD28,CD81,CEBPB,CSF1,CSF1R,CTNNBIP1,DROSHA"]
["GO:BP","regulation of immune effector process","GO:0002697",{"v":6.79083497130402e-10,"d":"6.79E-10"},461,235,45,18117,"ENPP3,AGER,AIM2,APPL2,SERPINB9,RPS19,BCL6,C5AR1,GPRC5B,GRN,HAVCR2,C3,STAP1,STAT5B,PRKCZ,PTAFR,NFKBID,HMGB1,HMOX1,HSPD1,ICAM1,IL18,IL18R1,IL18RAP,IL1R1,IL2RA,IL33,ITGAM,LGALS9,LYN,RASGRP1,TLR4,CCR2,CD28,CD300A,CD47,CD81,CD96,TNFAIP3,TNFRSF1B,UNC13D,CFH,DHX9,DNASE1,HK1"]
["GO:BP","positive regulation of cellular component movement","GO:0051272",{"v":1.50476914981313e-08,"d":"1.50E-08"},604,235,50,18117,"EGFR,ADAM17,AGER,APP,SERPINE1,RPS19,NOTCH1,ATM,PIK3CG,BCL6,C5AR1,F3,FGFR1,FN1,GRN,HDAC9,HGF,CAMK1D,PLA2G7,SPN,STAT3,STAT5A,STK39,PRKCA,PRKD1,PTAFR,PTGS2,HMGB1,HMOX1,ICAM1,IGF1,IL1R1,JAK2,JAM3,KIT,LGALS9,LYN,RARRES2,TGFB1,THBS1,CCL4,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","leukocyte differentiation","GO:0002521",{"v":1.66517243707748E-8,"d":"1.67E-08"},550,235,48,18117,"EIF2AK1,EPHA2,ADAM17,AGER,APP,RORA,NOTCH2,ATM,AXL,PDE2A,BCL6,FANCA,FANCD2,FCER1G,HDAC9,CAMK4,PPARG,SPN,STAT3,STAT5B,PRKCA,PRKCZ,PTPN2,NFKBID,HMGB1,IL18,IL18R1,IL2RA,ITGB6,KIT,LGALS9,LYN,MAPK14,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,TLR2,TLR4,CCR2,CD28,CD81,CEBPB,CSF1,CSF1R,CTNNBIP1,DROSHA"]
["GO:BP","positive regulation of locomotion","GO:0040017",{"v":1.72066752670861E-8,"d":"1.72E-08"},606,235,50,18117,"EGFR,ADAM17,AGER,APP,SERPINE1,NOTCH1,ATM,PIK3CG,C5AR1,F3,FGFR1,FN1,GRN,HDAC9,HGF,SLIT2,CAMK1D,PLA2G7,SPN,STAT3,STAT5A,STK39,PRKCA,PRKD1,PTAFR,PTGS2,HMGB1,HMOX1,ICAM1,IGF1,IL16,IL1R1,JAK2,JAM3,KIT,LGALS9,LYN,RARRES2,TGFB1,THBS1,CCL4,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","regulation of biological process","GO:0050789",{"v":1.93604369040023e-09,"d":"1.94E-09"},12091,235,223,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABI3BP,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,MS4A2,SCN9A,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,ATRN,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,UNC13D,VPS35,ZBP1,CEBPB,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","regulation of biological quality","GO:0065008",{"v":2.04482512857552E-8,"d":"2.04E-08"},4131,235,128,18117,"EDNRA,EDNRB,EGFR,EIF2AK1,ABCC1,ABCD1,ACE,ADAM17,AGER,ALOX5,METRNL,MFHAS1,APOE,APP,APPL2,SCN9A,SCNN1B,SERPINE1,SERPINF1,RORA,RPS19,NOTCH1,NR1H3,P2RX1,P2RX7,ATM,AXL,PDE2A,PIK3CG,BCL6,C5AR1,F3,F8,FABP4,FCER1G,FN1,FPR1,FPR3,GJA1,GRN,GSTP1,HCK,HDAC9,C3,SLC11A1,SLIT2,PLA2G4A,SNAP23,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGS1,PTGS2,PTPN2,PXK,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL1RAP,IL2RA,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRFN5,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RBPJ,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TLR2,TLR4,CCL5,CCR2,CD81,CDH5,TNFAIP3,TNFRSF1B,TRPV4,VPS35,CEBPB,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,DHX9,CX3CL1,CYBB,CYSLTR1,DAGLB,DDX3X,DUOXA1,HK1"]
["GO:BP","positive regulation of cellular protein metabolic process","GO:0032270",{"v":2.52177012457933E-8,"d":"2.52E-08"},1477,235,75,18117,"EDNRB,EGFR,ACE,ADAM17,AGER,AIM2,APOE,APP,RPS6KA5,NR1H3,NUPR1,P2RX1,ATM,PIK3CG,BCL6,C5AR1,F3,FGFR1,FN1,FPR1,GPRC5B,GRN,HGF,C3,SLC11A1,SNCA,PPARG,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,NFKBIA,HMGB1,HSPD1,ICAM1,IGF1,IL18,IL33,IRAK2,JAK2,KIT,LDLR,LGALS9,LPCAT3,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD28,CD300A,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,UACA,VPS35,CSF1,CSF1R,CTSC,DHX9,CX3CL1,CXCL17,DDX3X"]
["GO:BP","hematopoietic or lymphoid organ development","GO:0048534",{"v":4.36096480373411e-09,"d":"4.36E-09"},966,235,61,18117,"MECOM,EIF2AK1,EPHA2,ACE,ADAM17,AGER,MFHAS1,APP,RORA,RPS19,NOTCH1,NOTCH2,ATM,AXL,PDE2A,BCL6,FANCA,FANCD2,FCER1G,HDAC9,CAMK4,PPARG,SPN,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PSMA1,PTPN2,NFKBIA,NFKBID,HMGB1,HMGB2,HYAL2,IL18,IL18R1,IL2RA,ITGB6,JAK2,JAM3,KIT,LGALS9,LYN,MAPK14,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCR2,CD28,CD81,CEBPB,CSF1,CSF1R,CTNNBIP1,DROSHA"]
["GO:BP","positive regulation of cell migration","GO:0030335",{"v":6.09398385914309E-9,"d":"6.09E-09"},567,235,48,18117,"EGFR,ADAM17,AGER,APP,SERPINE1,NOTCH1,ATM,PIK3CG,C5AR1,F3,FGFR1,FN1,GRN,HDAC9,HGF,CAMK1D,PLA2G7,SPN,STAT3,STAT5A,STK39,PRKCA,PRKD1,PTAFR,PTGS2,HMGB1,HMOX1,ICAM1,IGF1,IL1R1,JAK2,JAM3,KIT,LGALS9,LYN,RARRES2,TGFB1,THBS1,CCL4,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","leukocyte proliferation","GO:0070661",{"v":1.1535003889412E-7,"d":"1.15E-07"},325,235,38,18117,"ENPP3,ACE,AGER,ATM,PIK3CG,BCL6,GSTP1,HAVCR2,SLC11A1,SPN,STAT5B,PRKCQ,HMGB1,HSPD1,IDO1,IGF1,IL18,IL2RA,IL33,KIT,LGALS9,LYN,RASGRP1,TCIRG1,TGFB1,TLR4,CCL5,CCR2,CD28,CD300A,CD6,CD81,TNFAIP3,TNFRSF1B,CEBPB,CSF1,CSF1R,CX3CL1"]
["GO:BP","positive regulation of protein metabolic process","GO:0051247",{"v":1.65295497857148E-7,"d":"1.65E-07"},1564,235,76,18117,"EDNRB,EGFR,ACE,ADAM17,AGER,AIM2,APOE,APP,RPS6KA5,NR1H3,NUPR1,P2RX1,ATM,PIK3CG,BCL6,C5AR1,F3,FGFR1,FN1,FPR1,GJA1,GPRC5B,GRN,HGF,C3,SLC11A1,SNCA,PPARG,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,NFKBIA,HMGB1,HSPD1,ICAM1,IGF1,IL18,IL33,IRAK2,JAK2,KIT,LDLR,LGALS9,LPCAT3,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD28,CD300A,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,UACA,VPS35,CSF1,CSF1R,CTSC,DHX9,CX3CL1,CXCL17,DDX3X"]
["GO:BP","mononuclear cell migration","GO:0071674",{"v":1.6985625971983e-07,"d":"1.70E-07"},191,235,31,18117,"ADAM17,AGER,ALOX5,APP,SERPINE1,RPS19,PIK3CG,C5AR1,SIRPA,SLIT2,PLA2G7,SPN,STK39,HMGB1,ICAM1,LGALS9,LYN,RARRES2,TGFB1,THBS1,CCL4,CCL5,CCR2,CD200,CD47,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","regulation of MAPK cascade","GO:0043408",{"v":1.86976515811381e-07,"d":"1.87E-07"},730,235,53,18117,"MECOM,EGFR,EPHA2,AGER,MFHAS1,APOE,APP,NOTCH1,NOTCH2,P2RX7,ASH1L,PDCD4,PIK3CG,C5AR1,FGFR1,FN1,FPR1,GSTP1,HAVCR2,HGF,SIRPA,SLAMF1,PJA2,STK39,PRKCA,PRKCZ,PTPN2,NDST1,HMGB1,HYAL2,ICAM1,IGF1,IRAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,THBS1,TLR4,CCL4,CCL5,CD300A,CD81,TNIP1,TRPV4,ULK4,CSF1R,CX3CL1,CXCL17,CYLD"]
["GO:BP","positive regulation of intracellular signal transduction","GO:1902533",{"v":2.84940738438235e-07,"d":"2.85E-07"},1037,235,62,18117,"EGFR,AGER,MFHAS1,APOE,APP,NOTCH1,NOTCH2,NUPR1,ATM,AXL,PDCD4,PIK3AP1,PIK3CG,C5AR1,F3,FGFR1,FN1,FPR1,GJA1,GPRC5B,HAVCR2,HGF,SLAMF1,PJA2,PPARD,STK39,PRKCA,PRKCZ,PRKD1,PTPN2,NDST1,HMGB1,HMOX1,ICAM1,IGF1,IL18,IL18R1,IRAK2,JAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,REL,RICTOR,TGM2,THBS1,TLR2,TLR4,CCL4,CCL5,CD28,CD81,TRPV4,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","positive regulation of cell motility","GO:2000147",{"v":3.59733317563057e-08,"d":"3.60E-08"},591,235,48,18117,"EGFR,ADAM17,AGER,APP,SERPINE1,NOTCH1,ATM,PIK3CG,C5AR1,F3,FGFR1,FN1,GRN,HDAC9,HGF,CAMK1D,PLA2G7,SPN,STAT3,STAT5A,STK39,PRKCA,PRKD1,PTAFR,PTGS2,HMGB1,HMOX1,ICAM1,IGF1,IL1R1,JAK2,JAM3,KIT,LGALS9,LYN,RARRES2,TGFB1,THBS1,CCL4,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","regulation of tumor necrosis factor production","GO:0032680",{"v":4.00765929748586e-09,"d":"4.01E-09"},163,235,29,18117,"AGER,APP,AXL,GSTP1,HAVCR2,SIRPA,SLAMF1,SPN,STAT3,PTAFR,HMGB1,IGF1,IL33,JAK2,LGALS9,LPL,LY96,MAPKAPK2,RASGRP1,THBS1,TLR1,TLR2,TLR4,CCR2,CD47,TNFAIP3,DHX9,DICER1,CX3CL1"]
["GO:BP","leukocyte mediated immunity","GO:0002443",{"v":5.48381086622469e-08,"d":"5.48E-08"},877,235,57,18117,"ACE,ADAM17,AGER,ALOX5,SERPINB9,OLR1,P2RX1,PIK3CG,BCL6,C5AR1,FCER1G,FPR1,GRN,GSTP1,HAVCR2,C3,SIRPA,SLC11A1,SNAP23,STAP1,STAT5B,PRCP,PRKCZ,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,HSPD1,ICAM1,IL18,IL18R1,IL18RAP,IL1R1,ITGAM,KIT,LGALS9,LYN,MAPK14,RASGRP1,TCIRG1,TLR2,TLR4,CCR2,CD28,CD300A,CD47,CD68,CD81,CD96,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X,DNASE1"]
["GO:BP","tumor necrosis factor production","GO:0032640",{"v":5.68711010747409e-08,"d":"5.69E-08"},165,235,29,18117,"AGER,APP,AXL,GSTP1,HAVCR2,SIRPA,SLAMF1,SPN,STAT3,PTAFR,HMGB1,IGF1,IL33,JAK2,LGALS9,LPL,LY96,MAPKAPK2,RASGRP1,THBS1,TLR1,TLR2,TLR4,CCR2,CD47,TNFAIP3,DHX9,DICER1,CX3CL1"]
["GO:BP","positive regulation of cell population proliferation","GO:0008284",{"v":6.16195884479702e-08,"d":"6.16E-08"},982,235,60,18117,"EDNRB,EGFR,ACER3,ADAM17,AGER,NOTCH1,NOTCH2,BCL6,C5AR1,F3,FGFR1,FN1,GJA1,GRN,HAVCR2,HCK,SLAMF1,CALCRL,PPARD,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGFR,PTGS2,NDUFS4,HMGB1,HMGB2,HMOX1,IGF1,IL18,IL2RA,JAK2,KIT,LGALS9,LYN,MAPK14,RBPJ,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR4,CCL5,CCR2,CD28,CD47,CD6,CD81,TNFAIP3,CSF1,CSF1R,DHX9,CX3CL1"]
["GO:BP","T cell activation","GO:0042110",{"v":6.48108049609985e-08,"d":"6.48E-08"},489,235,44,18117,"ADAM17,AGER,RORA,PIK3CG,BCL6,FANCA,FANCD2,FCER1G,HAVCR2,SIRPA,SLC11A1,CAMK4,SPN,STAT3,STAT5B,PRKCQ,PRKCZ,PTPN2,NFKBID,HMGB1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL18R1,IL2RA,KIT,LGALS9,LYN,RASGRP1,RELB,TCIRG1,TGFB1,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,TNFRSF1B,CEBPB,DROSHA"]
["GO:BP","regulation of tumor necrosis factor superfamily cytokine production","GO:1903555",{"v":7.970090680378e-08,"d":"7.97E-08"},167,235,29,18117,"AGER,APP,AXL,GSTP1,HAVCR2,SIRPA,SLAMF1,SPN,STAT3,PTAFR,HMGB1,IGF1,IL33,JAK2,LGALS9,LPL,LY96,MAPKAPK2,RASGRP1,THBS1,TLR1,TLR2,TLR4,CCR2,CD47,TNFAIP3,DHX9,DICER1,CX3CL1"]
["GO:BP","positive regulation of leukocyte migration","GO:0002687",{"v":9.59689944462389e-08,"d":"9.60E-08"},137,235,27,18117,"ADAM17,AGER,APP,SERPINE1,C5AR1,CAMK1D,PLA2G7,SPN,STK39,PTAFR,HMGB1,ICAM1,IL1R1,JAM3,LGALS9,RARRES2,TGFB1,THBS1,CCL4,CCL5,CCR2,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","cellular response to lipid","GO:0071396",{"v":1.06637420158204e-06,"d":"1.07E-06"},578,235,47,18117,"EDNRB,EGFR,SCNN1B,SERPINE1,SERPINF1,RORA,NR1H3,ATM,AXL,PDCD4,SGMS1,GSTP1,HAVCR2,HCK,SIRPA,PPARA,PPARD,PPARG,STAP1,PRKCA,PTAFR,NFKB1,NFKBIA,HMGB1,HMGB2,ICAM1,IL18,IRAK2,JAK2,LDLR,LPL,LY86,LY96,LYN,MAPK14,TGFB1,TLR2,TLR4,CCL5,CD6,CD68,CDK19,TNFAIP3,TNFRSF1B,CEBPB,CX3CL1,CXCL2"]
["GO:BP","cell adhesion","GO:0007155",{"v":1.20318678749755e-06,"d":"1.20E-06"},1492,235,73,18117,"EGFR,EPHA2,ABI3BP,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,APP,SERPINE1,NOTCH1,OLR1,ATM,ATRN,AXL,PIK3CG,BCL6,BCR,FN1,HAVCR2,HCK,SIRPA,SLAMF1,PPARA,PPARD,SPN,STAB1,STAT5B,PRKCA,PRKCQ,PRKCZ,PTAFR,PTPN2,NFKBID,HMGB1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL1RAP,IL2RA,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LRFN5,LYN,MAPK14,RASGRP1,TGFB1,TGM2,THBS1,THEMIS2,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CD96,CDH5,TNIP1,TRPV4,UNC13D,CEBPB,CSF1,CX3CL1"]
["GO:BP","tumor necrosis factor superfamily cytokine production","GO:0071706",{"v":1.31606155648378E-6,"d":"1.32E-06"},170,235,29,18117,"AGER,APP,AXL,GSTP1,HAVCR2,SIRPA,SLAMF1,SPN,STAT3,PTAFR,HMGB1,IGF1,IL33,JAK2,LGALS9,LPL,LY96,MAPKAPK2,RASGRP1,THBS1,TLR1,TLR2,TLR4,CCR2,CD47,TNFAIP3,DHX9,DICER1,CX3CL1"]
["GO:BP","gene expression","GO:0010467",{"v":1.54297485147271e-06,"d":"1.54E-06"},6179,235,156,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ADAM17,AGER,AIM2,AKNA,ALOX5,APOE,APP,APPL2,SCNN1B,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3CG,BCL6,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FN1,GBP5,GJA1,GPRC5B,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,CAMK1D,CAMK4,CASP4,PLD3,SNCA,PPARA,PPARD,PPARG,SPN,STAP1,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL33,IRAK2,ITGB6,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,THBS1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD47,CD6,CD81,CD96,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,DROSHA,HK1"]
["GO:BP","regulation of programmed cell death","GO:0043067",{"v":1.55060344216758E-6,"d":"1.55E-06"},1582,235,75,18117,"MECOM,EDNRB,EGFR,ABR,ACER3,ADAM17,APOE,SERPINB9,SERPINE1,NOTCH1,NOTCH2,NUPR1,ATM,AXL,PDCD4,PIK3CG,BCL6,SGMS1,C5AR1,FGFR1,GJA1,GPX4,GRN,GSTP1,HCK,HGF,SLIT2,CAMK1D,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT5B,PRKCA,PRKCQ,PRKCZ,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,ITGAM,JAK2,KIT,LGALS9,LRRK2,LYN,TGFB1,TGM2,THBS1,TIMP1,CCL5,CD28,CDH5,CDK19,TNFAIP3,TNFRSF1B,ZBP1,CEBPB,CSF1R,CTSC,CX3CL1,CYLD,DDX3X"]
["GO:BP","biological adhesion","GO:0022610",{"v":1.55060344216758E-6,"d":"1.55E-06"},1499,235,73,18117,"EGFR,EPHA2,ABI3BP,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,APP,SERPINE1,NOTCH1,OLR1,ATM,ATRN,AXL,PIK3CG,BCL6,BCR,FN1,HAVCR2,HCK,SIRPA,SLAMF1,PPARA,PPARD,SPN,STAB1,STAT5B,PRKCA,PRKCQ,PRKCZ,PTAFR,PTPN2,NFKBID,HMGB1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL1RAP,IL2RA,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LRFN5,LYN,MAPK14,RASGRP1,TGFB1,TGM2,THBS1,THEMIS2,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CD96,CDH5,TNIP1,TRPV4,UNC13D,CEBPB,CSF1,CX3CL1"]
["GO:BP","regulation of macrophage activation","GO:0043030",{"v":1.55275529601035e-06,"d":"1.55E-06"},65,235,21,18117,"MFHAS1,RORA,NR1H3,ATM,GRN,HAVCR2,PJA2,PLA2G4A,SNCA,STAP1,HSPD1,IL1RL1,IL33,LDLR,LRFN5,LRRK2,THBS1,TLR4,CD200,CTSC,CX3CL1"]
["GO:BP","MAPK cascade","GO:0000165",{"v":1.8846923110412E-6,"d":"1.88E-06"},935,235,58,18117,"MECOM,EGFR,EPHA2,AGER,MFHAS1,APOE,APP,NOTCH1,NOTCH2,P2RX7,ASH1L,PDCD4,PIK3CG,C5AR1,FGFR1,FN1,FPR1,GSTP1,HAVCR2,HGF,SIRPA,SLAMF1,PJA2,STK39,PRKCA,PRKCZ,PSMA1,PTPN2,NDST1,NFKB1,HMGB1,HYAL2,ICAM1,IGF1,IL18,IL2RA,IRAK2,JAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,THBS1,TLR4,CCL4,CCL5,CD300A,CD81,TNIP1,TRPV4,ULK4,CSF1R,CX3CL1,CXCL17,CYLD"]
["GO:BP","lymphocyte activation","GO:0046649",{"v":2.15288439603477e-06,"d":"2.15E-06"},771,235,53,18117,"ADAM17,AGER,RORA,NOTCH2,ATM,AXL,PIK3CG,BCL6,FANCA,FANCD2,FCER1G,HAVCR2,HDAC9,SIRPA,SLAMF1,SLC11A1,CAMK4,SPN,STAT3,STAT5B,PRKCQ,PRKCZ,PTPN2,NFKBID,HMGB1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL18R1,IL2RA,KIT,LGALS9,LYN,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,TLR4,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,TNFAIP3,TNFRSF1B,UNC13D,CEBPB,DROSHA"]
["GO:BP","leukocyte chemotaxis","GO:0030595",{"v":2.24021282615009e-07,"d":"2.24E-07"},227,235,32,18117,"EDNRB,ADAM17,ALOX5,SERPINE1,RPS19,PIK3CG,C5AR1,FCER1G,SLIT2,CAMK1D,PLA2G7,STAP1,STK39,HMGB1,IL16,JAM3,KIT,LGALS9,LYN,RARRES2,THBS1,CCL4,CCL5,CCR2,TRPV4,CMKLR1,CNR2,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","biological regulation","GO:0065007",{"v":2.26004360217168E-7,"d":"2.26E-07"},12809,235,226,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABI3BP,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,MS4A2,SCN9A,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,ATRN,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,SNAP23,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,UNC13D,VPS35,ZBP1,CEBPB,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","multicellular organism development","GO:0007275",{"v":4.96897330177178e-07,"d":"4.97E-07"},5613,235,147,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ACER3,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,MFHAS1,APOE,APP,APPL2,SCN9A,SDC1,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NUPR1,P2RX7,ASH1L,ATM,ATRN,AXL,PDCD4,PDE2A,PIK3CG,BCL6,BCR,C5AR1,F3,FANCA,FANCD2,FCER1G,FGFR1,FN1,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HDAC9,HGF,C3,SLIT2,CALCRL,CAMK1D,CAMK4,PMP22,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NDST1,NDUFS4,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL1RAP,IL2RA,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LIPA,LRFN5,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,RELB,RICTOR,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCR2,CD28,CD81,CDH5,TNFAIP3,TNFRSF1B,TRPV4,ULK4,VPS35,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DICER1,CX3CL1,CXCL17,CYBB,DAGLB,DROSHA,DUOXA1"]
["GO:BP","protein phosphorylation","GO:0006468",{"v":7.69952473362056e-07,"d":"7.70E-07"},1668,235,76,18117,"EDNRB,EGFR,EIF2AK1,EPHA2,ABR,ACE,ADAM17,AGER,APOE,APP,RPS6KA5,ATM,AXL,PDCD4,PIK3CG,BCR,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGS2,PTPN2,PXK,NDUFS4,HMGB1,HYAL2,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR2,TLR4,CCL5,CD300A,CD81,CDH5,CDK19,TNFAIP3,ULK4,CIITA,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","response to endogenous stimulus","GO:0009719",{"v":1.32933077942738E-5,"d":"1.33E-05"},1683,235,76,18117,"EDNRB,EGFR,ABCC1,ADAM17,ADAMTS12,AGER,APOE,APP,APPL2,SCNN1B,SDC1,SERPINB9,SERPINF1,NOTCH1,NOTCH2,NR1H3,P2RX7,PDCD4,PDE2A,PIK3CG,FCER1G,FGFR1,GJA1,GSTP1,HDAC9,SLIT2,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRCP,PRKCQ,PRKCZ,PTAFR,PTGFR,PTGS2,PTPN2,NDST1,NFKB1,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,ITGB6,JAK2,KIT,LDLR,LPL,LRRK2,LYN,RARRES2,RBPJ,TCIRG1,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL5,CD68,CD81,CDH5,TRPV4,VPS35,CEBPB,CSRP3,CTSS,CYBB"]
["GO:BP","regulation of interleukin-6 production","GO:0032675",{"v":1.51257554061548e-05,"d":"1.51E-05"},168,235,28,18117,"AGER,APP,HAVCR2,HGF,SIRPA,SLAMF1,STAT3,PTAFR,HMGB1,HSPD1,HYAL2,IL16,IL17RA,IL1RAP,IL33,LGALS9,LPL,MAPKAPK2,TLR1,TLR2,TLR4,CD200,CD47,TNFAIP3,TRPV4,CEBPB,DHX9,CX3CL1"]
["GO:BP","regulation of leukocyte mediated immunity","GO:0002703",{"v":1.98820141929772e-06,"d":"1.99E-06"},205,235,30,18117,"AGER,SERPINB9,BCL6,HAVCR2,C3,STAP1,STAT5B,PRKCZ,PTAFR,HMGB1,HMOX1,HSPD1,ICAM1,IL18,IL18R1,IL18RAP,IL1R1,ITGAM,LGALS9,LYN,RASGRP1,TLR4,CCR2,CD28,CD300A,CD81,CD96,TNFRSF1B,UNC13D,DNASE1"]
["GO:BP","negative regulation of biological process","GO:0048519",{"v":2.05489425787073E-5,"d":"2.05E-05"},5757,235,148,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCD1,ACE,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,METRNL,MFHAS1,APOE,APP,APPL2,AOAH,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3CG,BCL6,C5AR1,FABP4,FANCD2,FN1,GJA1,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGFR,PTGIS,PTGS2,PTPN2,PXK,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL1R2,IL1RL1,IL2RA,IL33,ITGAM,JAK2,JAM3,KIT,LDLR,LGALS9,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY96,LYN,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD68,CD96,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,VPS35,CEBPB,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,DROSHA"]
["GO:BP","regulation of catalytic activity","GO:0050790",{"v":2.38576933851606E-5,"d":"2.39E-05"},2545,235,94,18117,"MCPH1,EDNRA,EDNRB,EGFR,EPHA2,ABR,ACE,ADAM17,AGER,AIM2,ALOX5AP,APOE,APP,SERPINB9,SERPINE1,SERPINF1,NOTCH1,NR1H3,NUPR1,P2RX1,AXL,PARP4,PDCD4,PIK3CG,BCL6,BCR,C5AR1,F3,FABP4,FGFR1,FN1,FPR1,GPRC5B,GRN,GSTP1,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,PPARG,SOCS3,STAP1,STAT3,STK39,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGS2,PTPN2,PXK,NFKB1,HMGB1,HMGB2,HSPD1,HYAL2,ICAM1,IGF1,IL18,IRAK2,ITGAM,JAK2,KIT,LGALS9,LPL,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TIMP1,TLR4,CCL4,CCL5,CCR2,CD200,CD300A,CD81,TNFAIP3,UACA,CNR2,CSF1,CSF1R,DHX9,CX3CL1,CXCL17,DDX3X"]
["GO:BP","mononuclear cell differentiation","GO:1903131",{"v":2.65957403450016e-06,"d":"2.66E-06"},430,235,40,18117,"ADAM17,AGER,RORA,NOTCH2,ATM,AXL,PDE2A,BCL6,FANCA,FANCD2,FCER1G,HDAC9,CAMK4,PPARG,SPN,STAT3,STAT5B,PRKCZ,PTPN2,NFKBID,HMGB1,IL18,IL18R1,IL2RA,ITGB6,KIT,LGALS9,LYN,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,CCR2,CD28,CEBPB,CSF1,CSF1R,CTNNBIP1,DROSHA"]
["GO:BP","interleukin-6 production","GO:0032635",{"v":2.86769136525145e-05,"d":"2.87E-05"},172,235,28,18117,"AGER,APP,HAVCR2,HGF,SIRPA,SLAMF1,STAT3,PTAFR,HMGB1,HSPD1,HYAL2,IL16,IL17RA,IL1RAP,IL33,LGALS9,LPL,MAPKAPK2,TLR1,TLR2,TLR4,CD200,CD47,TNFAIP3,TRPV4,CEBPB,DHX9,CX3CL1"]
["GO:BP","negative regulation of cytokine production","GO:0001818",{"v":2.92556828512387e-06,"d":"2.93E-06"},381,235,38,18117,"EPHA2,ABCD1,AGER,APPL2,RPS6KA5,AXL,PDCD4,BCL6,FN1,GSTP1,HAVCR2,HDAC9,HGF,SIRPA,SLAMF1,SLC11A1,PPARA,NFKB1,HMGB1,HMOX1,IDO1,IGF1,IL1R2,IL1RL1,IL33,LGALS9,REL,RELB,TGFB1,THBS1,TLR4,CD200,CD96,TNFAIP3,CMKLR1,DICER1,CX3CL1,CYLD"]
["GO:BP","regulation of mononuclear cell migration","GO:0071675",{"v":4.95835160871791e-05,"d":"4.96E-05"},113,235,24,18117,"ADAM17,AGER,APP,SERPINE1,C5AR1,SLIT2,PLA2G7,SPN,STK39,HMGB1,LGALS9,LYN,RARRES2,TGFB1,THBS1,CCL4,CCL5,CCR2,CD200,TRPV4,CMKLR1,CSF1,CSF1R,CXCL17"]
["GO:BP","negative regulation of cell death","GO:0060548",{"v":5.32829923214394e-06,"d":"5.33E-06"},1038,235,59,18117,"MECOM,EDNRB,EGFR,APOE,SERPINB9,SERPINE1,SERPINF1,NOTCH1,NOTCH2,NUPR1,AXL,PDCD4,PIK3CG,BCL6,C5AR1,GPX4,GRN,GSTP1,HCK,HGF,CAMK1D,SNCA,PPARA,PPARD,SOCS3,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGFR,PTGS2,NFKB1,NFKBIA,HMGB2,HMOX1,HSPD1,ICAM1,IDO1,IGF1,JAK2,KIT,LRRK2,REL,THBS1,TIMP1,CCL5,CD200,CD28,CDH5,TNFAIP3,TNFRSF1B,VPS35,CEBPB,CSF1,CSF1R,CX3CL1,DDX3X"]
["GO:BP","regulation of phosphorylation","GO:0042325",{"v":6.45715923366485e-06,"d":"6.46E-06"},1431,235,69,18117,"MCPH1,EDNRB,EGFR,EIF2AK1,EPHA2,ABCD1,ACE,ADAM17,AGER,APOE,APP,RPS6KA5,NUPR1,P2RX7,ATM,AXL,PDCD4,PIK3CG,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,PPARA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTGS2,PTPN2,NDUFS4,HMGB1,HYAL2,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CDH5,TNFAIP3,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","positive regulation of cellular metabolic process","GO:0031325",{"v":7.14563307172375e-07,"d":"7.15E-07"},3274,235,107,18117,"MECOM,EDNRB,EGFR,ELF3,EPHA2,ABCD1,ACE,ADAM17,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PIK3CG,BCL6,C5AR1,F3,FGFR1,FN1,FPR1,GPRC5B,GRN,GSTP1,HGF,C3,SLC11A1,CAMK4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5B,STK39,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RICTOR,TGFB1,THBS1,TLR2,TLR4,CCL5,CD28,CD300A,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,UACA,VPS35,CEBPB,CIITA,CSF1,CSF1R,CSRP3,CTSC,DHX9,CX3CL1,CXCL17,DAGLB,DDX3X,DUOXA1"]
["GO:BP","response to organonitrogen compound","GO:0010243",{"v":8.46438342126971e-06,"d":"8.46E-06"},1085,235,60,18117,"EDNRB,EGFR,ABCC1,AGER,APOE,APP,APPL2,SDC1,SERPINF1,NOTCH1,P2RX1,P2RX7,PDE2A,PIK3CG,C5AR1,FCER1G,GJA1,GSTP1,HDAC9,SLIT2,CASP4,SNCA,PPARA,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PTAFR,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,HSPD1,ICAM1,IGF1,JAK2,LDLR,LPL,LRRK2,LYN,MAPK14,RARRES2,TCIRG1,TGFB1,TIMP1,TLR2,TLR4,CD68,CD81,TNFAIP3,TRPV4,VPS35,CEBPB,CNR2,CSRP3,CYBB"]
["GO:BP","developmental process","GO:0032502",{"v":9.14495258482661e-07,"d":"9.14E-07"},6628,235,159,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ACER3,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,METRNL,MFHAS1,APOE,APP,APPL2,SCN9A,SDC1,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,ATRN,AXL,PDCD4,PDE2A,PIK3CG,BCL6,BCR,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SLIT2,CALCRL,CAMK1D,CAMK4,PLD3,PMP22,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL1RAP,IL2RA,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LIPA,LPL,LRFN5,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,RELB,RICTOR,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCR2,CD28,CD68,CD81,CDH5,TNFAIP3,TNFRSF1B,TRPV4,ULK4,UNC13D,VPS35,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CXCL17,CYBB,DAGLB,DDX3X,DROSHA,DUOXA1"]
["GO:BP","regulation of multicellular organismal development","GO:2000026",{"v":0.000118103707514227,"d":"1.18E-04"},1447,235,69,18117,"EPHA2,ADAMTS12,AGER,ALOX5,APPL2,SERPINE1,SERPINF1,NOTCH1,NOTCH2,NUPR1,P2RX7,AXL,BCL6,C5AR1,F3,FANCA,FANCD2,FN1,GJA1,GRN,HGF,C3,SLIT2,CAMK4,PPARA,PPARD,PPARG,STAB1,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGIS,PTPN2,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,IGF1,IL18,IL1RAP,IL2RA,KIT,LDLR,LGALS9,LYN,MAPK14,RASGRP1,RBPJ,TGFB1,THBS1,TLR2,TLR4,CCR2,CD28,CDH5,TNFAIP3,TNFRSF1B,CEBPB,CSF1,CTNNBIP1,CTSC,DICER1,CX3CL1,CYBB,DROSHA"]
["GO:BP","response to nitrogen compound","GO:1901698",{"v":0.00013964013637856,"d":"1.40E-04"},1172,235,62,18117,"EDNRB,EGFR,ABCC1,AGER,APOE,APP,APPL2,SDC1,SERPINF1,NOTCH1,P2RX1,P2RX7,PDE2A,PIK3CG,C5AR1,FCER1G,GJA1,GSTP1,HDAC9,SLIT2,CASP4,SNCA,PPARA,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PTAFR,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,HSPD1,ICAM1,IGF1,JAK2,LDLR,LPL,LRRK2,LYN,MAPK14,RARRES2,TCIRG1,TGFB1,TIMP1,TLR2,TLR4,CD68,CD81,TNFAIP3,TRPV4,VPS35,CEBPB,CIITA,CNR2,CSRP3,DHX9,CYBB"]
["GO:BP","regulation of cell adhesion","GO:0030155",{"v":1.54418556431402E-5,"d":"1.54E-05"},748,235,50,18117,"EPHA2,ABI3BP,AGER,AKNA,ALOX5,SERPINE1,NOTCH1,ATM,PIK3CG,BCL6,FN1,HAVCR2,SIRPA,PPARA,SPN,STAT5B,PRKCA,PRKCQ,PRKCZ,PTAFR,PTPN2,NFKBID,HMGB1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL2RA,JAK2,JAM3,LGALS9,LYN,MAPK14,RASGRP1,TGFB1,TGM2,THBS1,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,TRPV4,UNC13D,CEBPB,CSF1,CX3CL1"]
["GO:BP","positive regulation of developmental process","GO:0051094",{"v":2.24335096233043e-06,"d":"2.24E-06"},1341,235,66,18117,"AGER,ALOX5,METRNL,APOE,SERPINE1,SERPINF1,NOTCH1,NOTCH2,P2RX7,AXL,BCL6,C5AR1,F3,FGFR1,FN1,GJA1,GPRC5B,GRN,HGF,C3,SLIT2,PPARD,PPARG,SOCS3,STAT3,STAT5B,PRKCA,PRKCZ,PRKD1,PTGIS,PTGS2,NFKB1,NFKBID,HMGB1,HMGB2,HMOX1,IGF1,IL18,IL1RAP,IL2RA,JAK2,KIT,LGALS9,LPL,LYN,MAPK14,RARRES2,RASGRP1,RBPJ,TGFB1,THBS1,TLR2,CD28,CDH5,TNFRSF1B,UNC13D,VPS35,CEBPB,CMKLR1,CSF1,CSRP3,CTNNBIP1,DICER1,CX3CL1,CYBB,DUOXA1"]
["GO:BP","regulation of apoptotic process","GO:0042981",{"v":0.00022985360856162,"d":"2.30E-04"},1549,235,71,18117,"EDNRB,EGFR,ABR,ADAM17,APOE,SERPINB9,SERPINE1,NOTCH1,NOTCH2,NUPR1,ATM,AXL,PDCD4,PIK3CG,BCL6,SGMS1,C5AR1,FGFR1,GJA1,GRN,GSTP1,HCK,HGF,SLIT2,CAMK1D,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT5B,PRKCA,PRKCQ,PRKCZ,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,ITGAM,JAK2,LGALS9,LRRK2,LYN,TGFB1,TGM2,THBS1,TIMP1,CCL5,CD28,CDH5,CDK19,TNFAIP3,TNFRSF1B,ZBP1,CEBPB,CSF1R,CTSC,CX3CL1,CYLD,DDX3X"]
["GO:BP","phosphorylation","GO:0016310",{"v":2.50287474318023e-05,"d":"2.50E-05"},2138,235,84,18117,"MCPH1,EDNRB,EGFR,EIF2AK1,EPHA2,ABCD1,ABR,ACE,ADAM17,AGER,AK7,APOE,APP,RPS6KA5,NUPR1,P2RX7,ATM,AXL,PDCD4,PIK3CG,BCR,SGMS1,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,SNCA,PPARA,SOCS3,STAP1,STAT3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGS2,PTPN2,PXK,NDUFS4,HMGB1,HYAL2,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR2,TLR4,CCL5,CD300A,CD81,CDH5,CDK19,TNFAIP3,ULK4,CIITA,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X,HK1"]
["GO:BP","regulation of chemotaxis","GO:0050920",{"v":0.000325518738913206,"d":"3.26E-04"},226,235,30,18117,"ADAM17,AGER,SERPINE1,NOTCH1,C5AR1,F3,FGFR1,GSTP1,SLIT2,CAMK1D,PLA2G7,STAP1,STK39,PRKD1,PTPN2,HMGB1,IL16,JAM3,LGALS9,LYN,RARRES2,THBS1,CCL4,CCL5,CCR2,TRPV4,CMKLR1,CSF1,CSF1R,CXCL17"]
["GO:BP","regulation of cellular protein metabolic process","GO:0032268",{"v":3.30744025112781E-4,"d":"3.31E-04"},2541,235,92,18117,"EDNRB,EGFR,EIF2AK1,ACE,ADAM17,AGER,AIM2,MFHAS1,APOE,APP,SERPINB9,SERPINE1,SERPINF1,RPS6KA5,NR1H3,NUPR1,P2RX1,ATM,PDCD4,PIK3CG,BCL6,C5AR1,F3,FABP4,FGFR1,FN1,FPR1,GPRC5B,GRN,GSTP1,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,PPARG,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,HMGB1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL1R2,IL33,IRAK2,JAK2,KIT,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TIMP1,TLR4,CCL5,CD28,CD300A,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,UACA,VPS35,CSF1,CSF1R,CTSC,DHX9,CX3CL1,CXCL17,DDX3X"]
["GO:BP","cell differentiation","GO:0030154",{"v":0.000436430996648849,"d":"4.36E-04"},4350,235,124,18117,"MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ACE,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,METRNL,MFHAS1,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,ATRN,AXL,PDCD4,PDE2A,BCL6,BCR,C5AR1,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,GJA1,GPRC5B,GRN,GSTP1,HCK,HDAC9,HGF,C3,SLIT2,CAMK1D,CAMK4,PLD3,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGS2,PTPN2,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL2RA,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LPL,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,RBPJ,RELB,TBC1D23,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCR2,CD28,CD81,CDH5,TNFRSF1B,TRPV4,ULK4,UNC13D,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CXCL17,DAGLB,DDX3X,DROSHA,DUOXA1"]
["GO:BP","regulation of response to biotic stimulus","GO:0002831",{"v":5.54351490157458e-05,"d":"5.54E-05"},415,235,38,18117,"AIM2,APOE,APPL2,SERPINB9,RPS19,RPS6KA5,NR1H3,FCER1G,GBP5,GRN,HAVCR2,HCK,PPARG,SOCS3,STAT5B,PRKCA,PSMA1,PTPN2,NFKB1,HMGB1,HMGB2,HSPD1,IL18RAP,IL2RA,JAK2,LGALS9,LY86,LY96,LYN,RASGRP1,RELB,TLR4,CCL5,CD96,TNFAIP3,ZBP1,DHX9,CX3CL1"]
["GO:BP","cellular developmental process","GO:0048869",{"v":6.0401646701879e-05,"d":"6.04E-05"},4428,235,125,18117,"MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ACE,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,METRNL,MFHAS1,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,ATRN,AXL,PDCD4,PDE2A,BCL6,BCR,C5AR1,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,GJA1,GPRC5B,GRN,GSTP1,HCK,HDAC9,HGF,C3,SLIT2,CAMK1D,CAMK4,PLD3,PMP22,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGS2,PTPN2,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL2RA,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LPL,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,RBPJ,RELB,TBC1D23,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCR2,CD28,CD81,CDH5,TNFRSF1B,TRPV4,ULK4,UNC13D,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CXCL17,DAGLB,DDX3X,DROSHA,DUOXA1"]
["GO:BP","regulation of cell-cell adhesion","GO:0022407",{"v":7.41861211756591e-05,"d":"7.42E-05"},445,235,39,18117,"AGER,AKNA,ALOX5,NOTCH1,BCL6,HAVCR2,SIRPA,PPARA,SPN,STAT5B,PRKCA,PRKCQ,PRKCZ,PTAFR,PTPN2,NFKBID,HMGB1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL2RA,JAK2,LGALS9,LYN,MAPK14,RASGRP1,TGFB1,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,TRPV4,CEBPB,CX3CL1"]
["GO:BP","negative regulation of immune system process","GO:0002683",{"v":8.30927415256456e-05,"d":"8.31E-05"},420,235,38,18117,"ENPP3,SERPINB9,RPS19,NR1H3,ATM,AXL,BCL6,GRN,HAVCR2,SLIT2,PPARG,SPN,STAP1,PSMA1,PTPN2,HMGB1,HMOX1,IDO1,IL1RL1,IL2RA,IL33,LDLR,LGALS9,LRFN5,LYN,TGFB1,THBS1,TLR4,CCR2,CD200,CD300A,CD47,CD68,CD96,TNFAIP3,CEBPB,CNR2,CX3CL1"]
["GO:BP","anatomical structure development","GO:0048856",{"v":8.37957198595461e-05,"d":"8.38E-05"},6106,235,150,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ACER3,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,MFHAS1,APOE,APP,APPL2,SCN9A,SDC1,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NUPR1,P2RX7,ASH1L,ATM,ATRN,AXL,PDCD4,PDE2A,PIK3CG,BCL6,BCR,C5AR1,F3,FANCA,FANCD2,FCER1G,FGFR1,FN1,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SLIT2,CALCRL,CAMK1D,CAMK4,PLD3,PMP22,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NDST1,NDUFS4,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL1RAP,IL2RA,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,LDLR,LGALS9,LIPA,LRFN5,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,RELB,RICTOR,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCR2,CD28,CD81,CDH5,TNFAIP3,TNFRSF1B,TRPV4,ULK4,UNC13D,VPS35,CEBPB,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DICER1,CX3CL1,CXCL17,CYBB,DAGLB,DROSHA,DUOXA1"]
["GO:BP","secretion","GO:0046903",{"v":8.50330859323633E-5,"d":"8.50E-05"},1501,235,69,18117,"EDNRB,EGFR,ACE,ALOX5,APOE,APP,SDC1,SERPINE1,NOTCH1,NR1H3,OLR1,P2RX1,AXL,PIK3CG,C5AR1,F8,FCER1G,FN1,FPR1,GJA1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,PLA2G4A,SNAP23,SNCA,PPARD,STAT5A,STAT5B,STK39,PRCP,PRKCA,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,IGF1,ITGAM,JAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,TCIRG1,THBS1,TIMP1,TLR2,TLR4,CCL5,CCR2,CD200,CD300A,CD47,CD68,TNFRSF1B,TRPV4,UNC13D,CTSC,CTSS,CYBB,DDX3X"]
["GO:BP","regulation of cellular process","GO:0050794",{"v":9.64289547114779e-05,"d":"9.64E-05"},11473,235,212,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCD1,ABI3BP,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,MS4A2,SCN9A,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,UNC13D,VPS35,ZBP1,CEBPB,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1"]
["GO:BP","regulated exocytosis","GO:0045055",{"v":1.17012827985748E-3,"d":"1.17E-03"},785,235,50,18117,"ALOX5,APP,SERPINE1,NOTCH1,OLR1,P2RX1,PIK3CG,C5AR1,F8,FCER1G,FN1,FPR1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,SNAP23,SNCA,PRCP,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,IGF1,ITGAM,KIT,LGALS9,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,TCIRG1,THBS1,TIMP1,TLR2,CCR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X"]
["GO:BP","positive regulation of immune response","GO:0050778",{"v":0.000124819737993142,"d":"1.25E-04"},753,235,49,18117,"AIM2,APPL2,RPS19,RPS6KA5,C5AR1,FCER1G,FPR1,FPR3,GBP5,HAVCR2,HCK,C3,SLC11A1,PLA2G4A,STAP1,STAT5B,PRKCQ,PRKCZ,PSMA1,PTAFR,PTPN2,NFKB1,NFKBID,HMGB1,HMGB2,HSPD1,IDO1,IL18,IL18R1,IL18RAP,IL1R1,IL33,ITGAM,LGALS9,LYN,RASGRP1,RELB,THEMIS2,TLR4,CCL5,CCR2,CD28,CD300A,CD47,CD81,ZBP1,CFH,CMKLR1,DHX9"]
["GO:BP","regulation of phosphate metabolic process","GO:0019220",{"v":0.00141687411221426,"d":"1.42E-03"},1645,235,72,18117,"MCPH1,EDNRB,EGFR,EIF2AK1,EPHA2,ABCD1,ACE,ADAM17,AGER,MFHAS1,APOE,APP,RPS6KA5,NUPR1,P2RX7,ATM,AXL,PDCD4,PIK3CG,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,PPARA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,PTPN2,NDUFS4,HMGB1,HYAL2,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LDLR,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CDH5,TNFAIP3,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","regulation of phosphorus metabolic process","GO:0051174",{"v":0.00141687411221426,"d":"1.42E-03"},1645,235,72,18117,"MCPH1,EDNRB,EGFR,EIF2AK1,EPHA2,ABCD1,ACE,ADAM17,AGER,MFHAS1,APOE,APP,RPS6KA5,NUPR1,P2RX7,ATM,AXL,PDCD4,PIK3CG,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,PPARA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,PTPN2,NDUFS4,HMGB1,HYAL2,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LDLR,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CDH5,TNFAIP3,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","positive regulation of phosphorus metabolic process","GO:0010562",{"v":0.000148510154967931,"d":"1.49E-04"},1001,235,56,18117,"EDNRB,EGFR,EPHA2,ACE,ADAM17,AGER,APP,RPS6KA5,NUPR1,P2RX7,ATM,AXL,PIK3CG,C5AR1,FGFR1,FPR1,GPRC5B,HGF,C3,SLC11A1,SNCA,PPARA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,HMGB1,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CDH5,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","positive regulation of phosphate metabolic process","GO:0045937",{"v":0.000148510154967931,"d":"1.49E-04"},1001,235,56,18117,"EDNRB,EGFR,EPHA2,ACE,ADAM17,AGER,APP,RPS6KA5,NUPR1,P2RX7,ATM,AXL,PIK3CG,C5AR1,FGFR1,FPR1,GPRC5B,HGF,C3,SLC11A1,SNCA,PPARA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,HMGB1,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CDH5,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","regulation of DNA-binding transcription factor activity","GO:0051090",{"v":1.67392862270915E-3,"d":"1.67E-03"},456,235,39,18117,"AGER,AIM2,APP,RPS6KA5,NUPR1,FANCA,FANCD2,HAVCR2,HCK,CAMK1D,PPARG,STAT3,PRKCQ,PRKCZ,PRKD1,PTGIS,NFKB1,NFKBIA,HMOX1,ICAM1,IL18,IL18R1,IL18RAP,IL1RAP,IRAK2,JAK2,KIT,LGALS9,MAPK14,TGFB1,TLR2,TLR4,CD200,TNFAIP3,CMKLR1,CTNNBIP1,DHX9,CX3CL1,CYLD"]
["GO:BP","phosphate-containing compound metabolic process","GO:0006796",{"v":0.00201217321675811,"d":"2.01E-03"},3087,235,101,18117,"MCPH1,EDNRB,EGFR,EIF2AK1,ENPP3,EPHA2,ABCD1,ABHD12,ABR,ACE,ADAM17,AGER,AK7,MFHAS1,APOE,APP,RORA,RPS6KA5,NR1H3,NUPR1,P2RX7,ATM,AXL,PDCD4,PDE2A,PDE5A,PIK3CG,BCR,SGMS1,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GPX4,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,SOCS3,STAP1,STAT3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGIS,PTGS2,PTPN2,PXK,NDUFS4,HMGB1,HYAL2,ICAM1,IDO1,IGF1,IL18,IRAK2,JAK2,KIT,LDLR,LPCAT3,LPL,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR2,TLR4,CCL5,CD300A,CD81,CDH5,CDK19,TNFAIP3,ULK4,CIITA,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X,HK1"]
["GO:BP","regulation of protein phosphorylation","GO:0001932",{"v":2.23052301406368E-4,"d":"2.23E-04"},1240,235,62,18117,"EDNRB,EGFR,EIF2AK1,ACE,ADAM17,AGER,APOE,APP,RPS6KA5,ATM,PDCD4,PIK3CG,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTGS2,PTPN2,NDUFS4,HMGB1,HYAL2,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CDH5,TNFAIP3,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","myeloid cell activation involved in immune response","GO:0002275",{"v":0.00259415873043571,"d":"2.59E-03"},547,235,42,18117,"ENPP3,ALOX5,OLR1,P2RX1,PIK3CG,C5AR1,FCER1G,FPR1,GRN,GSTP1,HAVCR2,C3,SIRPA,SLAMF1,SLC11A1,SNAP23,PRCP,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,IL33,ITGAM,KIT,LGALS9,LYN,MAPK14,RASGRP1,TCIRG1,TLR2,CCR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X,DNASE1"]
["GO:BP","myeloid leukocyte mediated immunity","GO:0002444",{"v":0.0033972838318229,"d":"3.40E-03"},551,235,42,18117,"ACE,ADAM17,ALOX5,SERPINB9,OLR1,P2RX1,PIK3CG,C5AR1,FCER1G,FPR1,GRN,GSTP1,C3,SIRPA,SLC11A1,SNAP23,STAP1,PRCP,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,ITGAM,KIT,LGALS9,LYN,MAPK14,RASGRP1,TCIRG1,TLR2,CCR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X,DNASE1"]
["GO:BP","phosphorus metabolic process","GO:0006793",{"v":0.00379456928818958,"d":"3.79E-03"},3114,235,101,18117,"MCPH1,EDNRB,EGFR,EIF2AK1,ENPP3,EPHA2,ABCD1,ABHD12,ABR,ACE,ADAM17,AGER,AK7,MFHAS1,APOE,APP,RORA,RPS6KA5,NR1H3,NUPR1,P2RX7,ATM,AXL,PDCD4,PDE2A,PDE5A,PIK3CG,BCR,SGMS1,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GPX4,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,SOCS3,STAP1,STAT3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGIS,PTGS2,PTPN2,PXK,NDUFS4,HMGB1,HYAL2,ICAM1,IDO1,IGF1,IL18,IRAK2,JAK2,KIT,LDLR,LPCAT3,LPL,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR2,TLR4,CCL5,CD300A,CD81,CDH5,CDK19,TNFAIP3,ULK4,CIITA,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X,HK1"]
["GO:BP","positive regulation of molecular function","GO:0044093",{"v":0.000475856289339278,"d":"4.76E-04"},1771,235,74,18117,"EDNRA,EGFR,EPHA2,ABR,ACE,ADAM17,AGER,AIM2,APOE,APP,RPS6KA5,NR1H3,P2RX1,AXL,PIK3CG,BCR,C5AR1,F3,FGFR1,FN1,FPR1,GPRC5B,GRN,HGF,SLC11A1,CAMK1D,SNCA,PPARG,STAP1,STAT3,STK39,PRKCQ,PRKCZ,PRKD1,PTAFR,NFKB1,HMGB1,HMGB2,HSPD1,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IRAK2,ITGAM,JAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD300A,CD81,UACA,CSF1,CSF1R,CTSS,DHX9,CX3CL1,CXCL17,DDX3X"]
["GO:BP","regulation of protein metabolic process","GO:0051246",{"v":0.000583667969778336,"d":"5.84E-04"},2704,235,93,18117,"EDNRB,EGFR,EIF2AK1,ACE,ADAM17,AGER,AIM2,MFHAS1,APOE,APP,SERPINB9,SERPINE1,SERPINF1,RPS6KA5,NR1H3,NUPR1,P2RX1,ATM,PDCD4,PIK3CG,BCL6,C5AR1,F3,FABP4,FGFR1,FN1,FPR1,GJA1,GPRC5B,GRN,GSTP1,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,PPARG,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,HMGB1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL1R2,IL33,IRAK2,JAK2,KIT,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TIMP1,TLR4,CCL5,CD28,CD300A,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,UACA,VPS35,CSF1,CSF1R,CTSC,DHX9,CX3CL1,CXCL17,DDX3X"]
["GO:BP","regulation of leukocyte proliferation","GO:0070663",{"v":0.000618430094908186,"d":"6.18E-04"},251,235,30,18117,"ENPP3,AGER,ATM,BCL6,GSTP1,HAVCR2,SPN,STAT5B,PRKCQ,HMGB1,IDO1,IGF1,IL18,IL2RA,IL33,LGALS9,LYN,TGFB1,TLR4,CCL5,CCR2,CD28,CD300A,CD6,CD81,TNFAIP3,TNFRSF1B,CEBPB,CSF1,CSF1R"]
["GO:BP","production of molecular mediator involved in inflammatory response","GO:0002532",{"v":0.00063832091223345,"d":"6.38E-04"},94,235,21,18117,"ABCD1,ALOX5,ALOX5AP,APPL2,SERPINE1,RPS19,P2RX1,PDCD4,GBP5,GRN,SIRPA,PLD3,SNAP23,PPARA,STAT3,IL1R2,KPNA6,LYN,MAPK14,TLR4,CD6"]
["GO:BP","positive regulation of phosphorylation","GO:0042327",{"v":7.51622540372786e-05,"d":"7.52E-05"},927,235,53,18117,"EDNRB,EGFR,EPHA2,ACE,ADAM17,AGER,APP,RPS6KA5,NUPR1,P2RX7,ATM,AXL,PIK3CG,C5AR1,FGFR1,FPR1,GPRC5B,HGF,C3,SLC11A1,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTGS2,HMGB1,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","negative regulation of cellular process","GO:0048523",{"v":0.000759164035007449,"d":"7.59E-04"},5139,235,134,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCD1,ACE,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,AXL,PDCD4,PDE2A,PIK3CG,BCL6,C5AR1,FABP4,FANCD2,GJA1,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CAMK1D,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL1R2,IL2RA,IL33,ITGAM,JAK2,JAM3,KIT,LDLR,LGALS9,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY96,LYN,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,VPS35,CEBPB,CIITA,CNR2,CSF1,CSF1R,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","positive regulation of chemotaxis","GO:0050921",{"v":0.0101612200576181,"d":"1.02E-02"},141,235,24,18117,"ADAM17,AGER,SERPINE1,C5AR1,F3,FGFR1,SLIT2,CAMK1D,PLA2G7,STK39,PRKD1,HMGB1,IL16,LGALS9,RARRES2,THBS1,CCL4,CCL5,CCR2,TRPV4,CMKLR1,CSF1,CSF1R,CXCL17"]
["GO:BP","secretion by cell","GO:0032940",{"v":1.14653139016415E-4,"d":"1.15E-04"},1364,235,64,18117,"EGFR,ALOX5,APOE,APP,SDC1,SERPINE1,NOTCH1,NR1H3,OLR1,P2RX1,AXL,PIK3CG,C5AR1,F8,FCER1G,FN1,FPR1,GJA1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,PLA2G4A,SNAP23,SNCA,PPARD,PRCP,PRKCA,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,IGF1,ITGAM,JAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,TCIRG1,THBS1,TIMP1,TLR2,TLR4,CCL5,CCR2,CD200,CD300A,CD47,CD68,TNFRSF1B,TRPV4,UNC13D,CTSC,CTSS,CYBB,DDX3X"]
["GO:BP","positive regulation of immune effector process","GO:0002699",{"v":0.0115836392340072,"d":"1.16E-02"},215,235,28,18117,"ENPP3,APPL2,RPS19,GPRC5B,C3,STAP1,STAT5B,PRKCZ,PTAFR,NFKBID,HMOX1,HSPD1,IL18,IL18R1,IL18RAP,IL1R1,IL33,ITGAM,LGALS9,LYN,RASGRP1,TLR4,CCR2,CD28,CD300A,CD81,UNC13D,HK1"]
["GO:BP","exocytosis","GO:0006887",{"v":0.0137449054649948,"d":"1.37E-02"},904,235,52,18117,"ALOX5,APP,SDC1,SERPINE1,NOTCH1,OLR1,P2RX1,PIK3CG,C5AR1,F8,FCER1G,FN1,FPR1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,SNAP23,SNCA,PRCP,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,IGF1,ITGAM,KIT,LGALS9,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,TCIRG1,THBS1,TIMP1,TLR2,CCL5,CCR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X"]
["GO:BP","positive regulation of catalytic activity","GO:0043085",{"v":0.0177804528166421,"d":"1.78E-02"},1418,235,65,18117,"EDNRA,EGFR,EPHA2,ABR,ACE,ADAM17,AGER,AIM2,APOE,APP,NR1H3,P2RX1,AXL,PIK3CG,BCR,C5AR1,F3,FGFR1,FN1,FPR1,GPRC5B,GRN,HGF,SLC11A1,SNCA,PPARG,STAP1,STAT3,STK39,PRKCQ,PRKCZ,PRKD1,PTAFR,HMGB1,HMGB2,HSPD1,ICAM1,IGF1,IL18,IRAK2,ITGAM,JAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL4,CCL5,CD200,CD300A,CD81,UACA,CSF1,CSF1R,DHX9,CX3CL1,CXCL17,DDX3X"]
["GO:BP","export from cell","GO:0140352",{"v":0.0177804528166421,"d":"1.78E-02"},1418,235,65,18117,"EGFR,ABCC1,ALOX5,APOE,APP,SDC1,SERPINE1,NOTCH1,NR1H3,OLR1,P2RX1,AXL,PIK3CG,C5AR1,F8,FCER1G,FN1,FPR1,GJA1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,PLA2G4A,SNAP23,SNCA,PPARD,PRCP,PRKCA,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,IGF1,ITGAM,JAK2,KIT,LGALS9,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,TCIRG1,THBS1,TIMP1,TLR2,TLR4,CCL5,CCR2,CD200,CD300A,CD47,CD68,TNFRSF1B,TRPV4,UNC13D,CTSC,CTSS,CYBB,DDX3X"]
["GO:BP","positive regulation of cell differentiation","GO:0045597",{"v":0.00229032669055325,"d":"2.29E-03"},879,235,51,18117,"AGER,METRNL,SERPINE1,SERPINF1,NOTCH1,NOTCH2,AXL,BCL6,FGFR1,FN1,GJA1,GPRC5B,HGF,SLIT2,PPARD,PPARG,SOCS3,STAT3,STAT5B,PRKCA,PRKCZ,PRKD1,PTGS2,NFKB1,NFKBID,HMGB1,HMGB2,IGF1,IL18,IL2RA,JAK2,KIT,LGALS9,LPL,LYN,MAPK14,RARRES2,RASGRP1,TGFB1,TLR2,CDH5,TNFRSF1B,UNC13D,CEBPB,CMKLR1,CSF1,CSRP3,CTNNBIP1,DICER1,CX3CL1,DUOXA1"]
["GO:BP","positive regulation of nitrogen compound metabolic process","GO:0051173",{"v":0.0230933930382005,"d":"2.31E-02"},3083,235,99,18117,"MECOM,EDNRB,EGFR,ELF3,ACE,ADAM17,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,PIK3CG,BCL6,C5AR1,F3,FGFR1,FN1,FPR1,GJA1,GPRC5B,GRN,HGF,C3,SLC11A1,CAMK4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5B,STK39,PRKCQ,PRKCZ,PRKD1,PTAFR,PTGS2,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL33,IRAK2,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RICTOR,TGFB1,THBS1,TLR2,TLR4,CCL5,CD28,CD300A,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,UACA,VPS35,CEBPB,CIITA,CSF1,CSF1R,CSRP3,CTSC,DHX9,CX3CL1,CXCL17,DDX3X"]
["GO:BP","regulation of innate immune response","GO:0045088",{"v":0.00231376306787349,"d":"2.31E-03"},309,235,32,18117,"AIM2,APOE,APPL2,SERPINB9,RPS19,RPS6KA5,NR1H3,FCER1G,GBP5,GRN,HAVCR2,HCK,PPARG,SOCS3,STAT5B,PSMA1,PTPN2,NFKB1,HMGB1,HMGB2,IL18RAP,JAK2,LGALS9,LYN,RASGRP1,RELB,TLR4,CCL5,CD96,TNFAIP3,ZBP1,DHX9"]
["GO:BP","chemical homeostasis","GO:0048878",{"v":0.0329523132692937,"d":"3.30E-02"},1229,235,60,18117,"EDNRA,EDNRB,EGFR,EIF2AK1,ABCD1,AGER,ALOX5,APOE,APP,APPL2,SCNN1B,SERPINF1,RORA,NR1H3,P2RX1,P2RX7,PIK3CG,C5AR1,FABP4,FPR1,FPR3,GJA1,GRN,GSTP1,HDAC9,SLC11A1,SNCA,PPARD,PPARG,STAT3,STK39,PRCP,PRKD1,PTGDR,PTGFR,PTPN2,HMGB1,HMOX1,HYAL2,ICAM1,IL18,ITGB6,JAK2,LDLR,LPL,LRRK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1,DDX3X,HK1"]
["GO:BP","regulation of T cell activation","GO:0050863",{"v":3.30511314701044E-3,"d":"3.31E-03"},337,235,33,18117,"AGER,BCL6,FANCA,FANCD2,HAVCR2,SIRPA,CAMK4,SPN,STAT5B,PRKCQ,PRKCZ,PTPN2,NFKBID,HMGB1,HSPD1,IDO1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,TNFRSF1B,CEBPB,DROSHA"]
["GO:BP","positive regulation of tumor necrosis factor production","GO:0032760",{"v":0.00341656129521149,"d":"3.42E-03"},88,235,20,18117,"AGER,APP,HAVCR2,SPN,STAT3,PTAFR,HMGB1,IL33,JAK2,LGALS9,LPL,LY96,MAPKAPK2,RASGRP1,THBS1,TLR1,TLR2,TLR4,CCR2,DHX9"]
["GO:BP","regulation of cellular metabolic process","GO:0031323",{"v":0.0411627718672459,"d":"4.12E-02"},6269,235,149,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ADAM17,AGER,AIM2,AKNA,ALOX5,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PIK3CG,BCL6,C5AR1,F3,FABP4,FANCA,FANCD2,FGFR1,FN1,FPR1,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1R2,IL1RAP,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL5,CD200,CD28,CD300A,CD47,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,VPS35,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DAGLB,DDX3X,DROSHA,DUOXA1"]
["GO:BP","cell-cell adhesion","GO:0098609",{"v":0.00459787491140061,"d":"4.60E-03"},894,235,51,18117,"EGFR,AGER,AKNA,ALOX5,NOTCH1,OLR1,PIK3CG,BCL6,FN1,HAVCR2,SIRPA,PPARA,SPN,STAT5B,PRKCA,PRKCQ,PRKCZ,PTAFR,PTPN2,NFKBID,HMGB1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL1RAP,IL2RA,ITGAM,JAK2,JAM3,KIT,LGALS9,LRFN5,LYN,MAPK14,RASGRP1,TGFB1,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CDH5,TNIP1,TRPV4,CEBPB,CX3CL1"]
["GO:BP","positive regulation of tumor necrosis factor superfamily cytokine production","GO:1903557",{"v":6.9045217729781e-05,"d":"6.90E-05"},91,235,20,18117,"AGER,APP,HAVCR2,SPN,STAT3,PTAFR,HMGB1,IL33,JAK2,LGALS9,LPL,LY96,MAPKAPK2,RASGRP1,THBS1,TLR1,TLR2,TLR4,CCR2,DHX9"]
["GO:BP","regulation of leukocyte chemotaxis","GO:0002688",{"v":6.9045217729781e-05,"d":"6.90E-05"},120,235,22,18117,"ADAM17,SERPINE1,C5AR1,SLIT2,CAMK1D,PLA2G7,STAP1,STK39,HMGB1,JAM3,LGALS9,LYN,RARRES2,THBS1,CCL4,CCL5,CCR2,TRPV4,CMKLR1,CSF1,CSF1R,CXCL17"]
["GO:BP","leukocyte cell-cell adhesion","GO:0007159",{"v":0.000978915966663753,"d":"9.79E-04"},375,235,34,18117,"AGER,ALOX5,OLR1,BCL6,HAVCR2,SIRPA,PPARA,SPN,STAT5B,PRKCQ,PRKCZ,PTAFR,PTPN2,NFKBID,HMGB1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,TNIP1,CEBPB"]
["GO:BP","positive regulation of protein phosphorylation","GO:0001934",{"v":0.105321121744263,"d":"1.05E-01"},840,235,49,18117,"EDNRB,EGFR,ACE,ADAM17,AGER,APP,RPS6KA5,ATM,PIK3CG,C5AR1,FGFR1,FPR1,GPRC5B,HGF,C3,SLC11A1,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTGS2,HMGB1,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","animal organ development","GO:0048513",{"v":0.129325882239053,"d":"1.29E-01"},3672,235,108,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ACE,ADAM17,ADAMTS12,AGER,AKNA,ALOX5,MFHAS1,APP,SDC1,SERPINE1,SERPINF1,RORA,RPS19,NOTCH1,NOTCH2,NUPR1,P2RX7,ASH1L,ATM,ATRN,AXL,PDCD4,PDE2A,BCL6,BCR,C5AR1,FANCA,FANCD2,FCER1G,FGFR1,FN1,GJA1,GSTP1,HDAC9,HGF,SLIT2,CALCRL,CAMK4,PPARA,PPARD,PPARG,SOCS3,SPN,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PSMA1,PTGS2,PTPN2,NDST1,NDUFS4,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL2RA,ITGAM,ITGB6,JAK2,JAM3,KIT,LGALS9,LIPA,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,RELB,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCR2,CD28,CD81,TNFAIP3,TNFRSF1B,TRPV4,CEBPB,CSF1,CSF1R,CSRP3,CTNNBIP1,DROSHA"]
["GO:BP","regulation of nitrogen compound metabolic process","GO:0051171",{"v":0.136917557500514,"d":"1.37E-01"},5848,235,142,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ACE,ADAM17,AGER,AIM2,AKNA,MFHAS1,APOE,APP,SERPINB9,SERPINE1,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,PARP4,PDCD4,PDE2A,PIK3CG,BCL6,C5AR1,F3,FABP4,FANCA,FANCD2,FGFR1,FN1,FPR1,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1R2,IL1RAP,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL5,CD200,CD28,CD300A,CD47,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,VPS35,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,DROSHA,DUOXA1"]
["GO:BP","regulation of transferase activity","GO:0051338",{"v":0.0172195670494009,"d":"1.72E-02"},1035,235,54,18117,"MCPH1,EGFR,EPHA2,ACE,ADAM17,AGER,APOE,APP,AXL,PARP4,PDCD4,PIK3CG,C5AR1,FABP4,FGFR1,FPR1,GPRC5B,GSTP1,HGF,SLC11A1,SNCA,PPARG,SOCS3,STAP1,STK39,PRKCQ,PRKCZ,PRKD1,PTPN2,HMGB1,HYAL2,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD200,CD300A,CD81,TNFAIP3,CSF1,CSF1R,CXCL17,DDX3X"]
["GO:BP","organic substance metabolic process","GO:0071704",{"v":0.249509425135659,"d":"2.50E-01"},11326,235,207,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AK7,AKNA,ALDH2,ALOX5,ALOX5AP,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL33,IRAK2,ITGAM,ITGB6,JAK2,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRRK2,LXN,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TPSB2,TRPV4,UACA,ULK4,VPS35,ZBP1,CEBPB,CERS6,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains","GO:0002460",{"v":0.0306762052326558,"d":"3.07E-02"},363,235,33,18117,"ADAM17,AGER,RORA,BCL6,FCER1G,HAVCR2,C3,SLC11A1,PLA2G4A,SPN,STAT3,PRKCQ,PRKCZ,NFKBID,HMGB1,HSPD1,ICAM1,IL18,IL18R1,IL1R1,IL1RL1,IL33,RELB,TCIRG1,TGFB1,TLR4,CCR2,CD28,CD81,TNFAIP3,TNFRSF1B,UNC13D,CTSC"]
["GO:BP","regulation of leukocyte cell-cell adhesion","GO:1903037",{"v":0.0319495957611501,"d":"3.19E-02"},338,235,32,18117,"AGER,ALOX5,BCL6,HAVCR2,SIRPA,PPARA,SPN,STAT5B,PRKCQ,PRKCZ,PTAFR,PTPN2,NFKBID,HMGB1,HSPD1,ICAM1,IDO1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,CEBPB"]
["GO:BP","macromolecule metabolic process","GO:0043170",{"v":0.0355614234538934,"d":"3.56E-02"},9796,235,191,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCD1,ABHD12,ABR,ACE,ADAM17,ADAMTS12,AGER,AIM2,AKNA,ALOX5,MFHAS1,APOE,APP,APPL2,AOAH,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL33,IRAK2,ITGB6,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LXN,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TPSB2,TRPV4,UACA,ULK4,VPS35,ZBP1,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,DNASE1,DROSHA,HK1"]
["GO:BP","acute inflammatory response","GO:0002526",{"v":0.0401067453910948,"d":"4.01E-02"},114,235,21,18117,"EDNRB,EIF2AK1,ALOX5AP,NUPR1,ASH1L,PIK3CG,F3,F8,FN1,GSTP1,C3,PPARG,STAT3,PRCP,PTGS2,ICAM1,CD163,CD6,CEBPB,CTNNBIP1,DNASE1"]
["GO:BP","negative regulation of programmed cell death","GO:0043069",{"v":0.424851280011112,"d":"4.25E-01"},943,235,51,18117,"MECOM,EDNRB,EGFR,APOE,SERPINB9,SERPINE1,NOTCH1,NOTCH2,NUPR1,AXL,PDCD4,PIK3CG,BCL6,C5AR1,GPX4,GRN,GSTP1,HCK,HGF,CAMK1D,SNCA,PPARA,PPARD,SOCS3,STAT5B,PRKCA,PRKCQ,PRKCZ,PTGFR,PTGS2,NFKB1,NFKBIA,HMGB2,HMOX1,HSPD1,ICAM1,IDO1,IGF1,JAK2,KIT,LRRK2,THBS1,TIMP1,CCL5,CD28,CDH5,TNFAIP3,CEBPB,CSF1R,CX3CL1,DDX3X"]
["GO:BP","positive regulation of cell activation","GO:0050867",{"v":0.0539476203528398,"d":"5.39E-02"},424,235,35,18117,"AGER,AXL,BCL6,HAVCR2,SIRPA,PLA2G4A,STAP1,STAT5B,PRKCQ,PRKCZ,PTAFR,NFKBID,HMGB1,HSPD1,IGF1,IL18,IL1RL1,IL2RA,IL33,ITGAM,JAK2,LGALS9,LRRK2,LYN,RASGRP1,TGFB1,THBS1,TLR4,CCL5,CCR2,CD28,CD47,CD6,CD81,CTSC"]
["GO:BP","chemokine production","GO:0032602",{"v":0.0591630802351998,"d":"5.92E-02"},101,235,20,18117,"EPHA2,ADAM17,AGER,APP,GSTP1,HAVCR2,SIRPA,HMGB1,HMOX1,IL17RA,IL18,IL1RL1,IL33,LGALS9,LPL,TLR2,TLR4,TRPV4,CSF1R,DDX3X"]
["GO:BP","tube development","GO:0035295",{"v":0.0644882941370794,"d":"6.45E-02"},1146,235,56,18117,"EDNRA,EDNRB,EGFR,EPHA2,ADAMTS12,ALOX5,APOE,SDC1,SERPINE1,SERPINF1,RORA,NOTCH1,NOTCH2,PIK3CG,C5AR1,F3,FN1,GJA1,GRN,HDAC9,HGF,C3,SLIT2,CALCRL,PPARG,STAB1,STAT3,PRCP,PRKCA,PRKD1,PTGIS,PTGS2,HMGB1,HMOX1,IL18,ITGB6,JAM3,KIT,LDLR,LIPA,MAPK14,RARRES2,RBPJ,TGFB1,TGM2,THBS1,CCR2,CDH5,TNFAIP3,CSF1,CSF1R,CTNNBIP1,DICER1,CX3CL1,CXCL17,CYBB"]
["GO:BP","mononuclear cell proliferation","GO:0032943",{"v":6.54363083312701E-3,"d":"6.54E-03"},297,235,30,18117,"ACE,AGER,ATM,PIK3CG,BCL6,HAVCR2,SLC11A1,SPN,STAT5B,PRKCQ,HMGB1,HSPD1,IDO1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,TLR4,CCL5,CCR2,CD28,CD300A,CD6,CD81,TNFRSF1B,CEBPB,CSF1"]
["GO:BP","negative regulation of leukocyte activation","GO:0002695",{"v":0.00687443775950629,"d":"6.87E-03"},188,235,25,18117,"ENPP3,NR1H3,ATM,AXL,BCL6,GRN,HAVCR2,SPN,PTPN2,HMGB1,HMOX1,IDO1,IL2RA,LDLR,LGALS9,LRFN5,LYN,TGFB1,CCR2,CD200,CD300A,TNFAIP3,CEBPB,CNR2,CX3CL1"]
["GO:BP","myeloid cell differentiation","GO:0030099",{"v":0.0711109495978613,"d":"7.11E-02"},428,235,35,18117,"EIF2AK1,EPHA2,MFHAS1,APP,RPS19,NOTCH2,PDE2A,BCL6,CAMK4,PPARG,STAT3,STAT5B,PRKCA,PRKCQ,PTPN2,NFKBIA,HMGB1,HMGB2,ITGB6,JAK2,KIT,LYN,MAPK14,RBPJ,RELB,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CD81,CEBPB,CSF1,CSF1R,CTNNBIP1"]
["GO:BP","regulation of kinase activity","GO:0043549",{"v":0.0815153449774095,"d":"8.15E-02"},921,235,50,18117,"MCPH1,EGFR,EPHA2,ACE,ADAM17,AGER,APOE,APP,AXL,PDCD4,PIK3CG,C5AR1,FABP4,FGFR1,FPR1,GPRC5B,GSTP1,HGF,SLC11A1,SNCA,SOCS3,STAP1,STK39,PRKCZ,PRKD1,PTPN2,HMGB1,HYAL2,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,TNFAIP3,CSF1,CSF1R,CXCL17,DDX3X"]
["GO:BP","negative regulation of cell activation","GO:0050866",{"v":0.0957647279492348,"d":"9.58E-02"},211,235,26,18117,"ENPP3,APOE,NR1H3,ATM,AXL,BCL6,GRN,HAVCR2,SPN,PTPN2,HMGB1,HMOX1,IDO1,IL2RA,LDLR,LGALS9,LRFN5,LYN,TGFB1,CCR2,CD200,CD300A,TNFAIP3,CEBPB,CNR2,CX3CL1"]
["GO:BP","regulation of transport","GO:0051049",{"v":0.0987718143704364,"d":"9.88E-02"},1809,235,71,18117,"EDNRA,EDNRB,EGFR,ALOX5,APOE,APP,APPL2,SCN9A,SDC1,SERPINE1,NOTCH1,NR1H3,P2RX1,P2RX7,AXL,PIK3CG,FCER1G,GJA1,HCK,C3,SIRPA,SLC11A1,CAMK1D,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STAP1,STK39,PRKCA,PRKCZ,PRKD1,PTAFR,PTGS2,PXK,NFKB1,NFKBIA,HMGB1,HMOX1,HYAL2,ICAM1,IGF1,IL16,ITGAM,JAK2,LGALS9,LPCAT3,LRRK2,LYN,MAPK14,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD300A,CD47,CD81,TNFRSF1B,UNC13D,VPS35,CEBPB,CTSS,DHX9,CX3CL1,CYBB"]
["GO:BP","response to peptide","GO:1901652",{"v":1.01877064329829,"d":"1.02E+00"},551,235,39,18117,"EDNRB,ABCC1,AGER,APP,APPL2,SERPINF1,NOTCH1,GJA1,GSTP1,HDAC9,CASP4,PPARA,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PTGS2,PTPN2,NFKB1,NFKBIA,ICAM1,IGF1,JAK2,LPL,LYN,MAPK14,RARRES2,TCIRG1,TGFB1,TIMP1,TLR2,TLR4,TNFAIP3,TRPV4,CSRP3,CYBB"]
["GO:BP","regulation of primary metabolic process","GO:0080090",{"v":0.120721611595217,"d":"1.21E-01"},6053,235,143,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ABCD1,ACE,ADAM17,AGER,AIM2,AKNA,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,PARP4,PDCD4,PDE2A,PIK3CG,BCL6,C5AR1,F3,FABP4,FANCA,FANCD2,FGFR1,FN1,FPR1,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1R2,IL1RAP,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TGFB1,THBS1,TIMP1,TLR2,TLR4,CCL5,CD200,CD28,CD300A,CD81,CDH5,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,VPS35,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DAGLB,DDX3X,DROSHA"]
["GO:BP","positive regulation of cell adhesion","GO:0045785",{"v":1.33981815457881,"d":"1.34E+00"},437,235,35,18117,"ABI3BP,AGER,ALOX5,ATM,BCL6,FN1,HAVCR2,SIRPA,STAT5B,PRKCA,PRKCQ,PRKCZ,PTAFR,NFKBID,HMGB1,HSPD1,ICAM1,IGF1,IL18,IL2RA,JAK2,LGALS9,LYN,RASGRP1,TGFB1,TGM2,CCL5,CCR2,CD28,CD47,CD6,CD81,UNC13D,CSF1,CX3CL1"]
["GO:BP","positive regulation of leukocyte activation","GO:0002696",{"v":0.165923423611953,"d":"1.66E-01"},412,235,34,18117,"AGER,AXL,BCL6,HAVCR2,SIRPA,PLA2G4A,STAP1,STAT5B,PRKCQ,PRKCZ,PTAFR,NFKBID,HMGB1,HSPD1,IGF1,IL18,IL1RL1,IL2RA,IL33,ITGAM,LGALS9,LRRK2,LYN,RASGRP1,TGFB1,THBS1,TLR4,CCL5,CCR2,CD28,CD47,CD6,CD81,CTSC"]
["GO:BP","vasculature development","GO:0001944",{"v":0.186425120487109,"d":"1.86E-01"},830,235,47,18117,"EDNRA,EPHA2,ALOX5,APOE,SERPINE1,SERPINF1,RORA,NOTCH1,NOTCH2,PDCD4,PDE2A,PIK3CG,C5AR1,F3,FN1,GRN,HDAC9,HGF,C3,SLIT2,CALCRL,PPARG,SOCS3,STAB1,STAT3,PRCP,PRKCA,PRKD1,PTGIS,PTGS2,NDST1,HMGB1,HMOX1,IL18,JAM3,KIT,LDLR,MAPK14,RBPJ,TGFB1,THBS1,CCR2,CDH5,TNFAIP3,CX3CL1,CXCL17,CYBB"]
["GO:BP","microglial cell activation","GO:0001774",{"v":0.19207909693991,"d":"1.92E-01"},55,235,16,18117,"AGER,APP,ATM,C5AR1,GRN,SNCA,STAP1,IL33,ITGAM,JAK2,LDLR,LRRK2,TLR1,TLR2,CTSC,CX3CL1"]
["GO:BP","leukocyte degranulation","GO:0043299",{"v":0.0249940821357904,"d":"2.50E-02"},535,235,38,18117,"ALOX5,OLR1,P2RX1,PIK3CG,C5AR1,FCER1G,FPR1,GRN,GSTP1,HCK,C3,SIRPA,SLC11A1,SNAP23,PRCP,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,ITGAM,KIT,LGALS9,LYN,MAPK14,RASGRP1,TCIRG1,TLR2,CCR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X"]
["GO:BP","lipopolysaccharide-mediated signaling pathway","GO:0031663",{"v":0.263613284944098,"d":"2.64E-01"},56,235,16,18117,"HCK,PRKCA,PTAFR,NFKBIA,IL18,IRAK2,LY86,LY96,LYN,MAPK14,TLR2,TLR4,CCL5,CD6,TNFAIP3,CX3CL1"]
["GO:BP","regulation of chemokine production","GO:0032642",{"v":0.266557280261978,"d":"2.67E-01"},94,235,19,18117,"EPHA2,ADAM17,AGER,APP,GSTP1,HAVCR2,SIRPA,HMGB1,HMOX1,IL17RA,IL1RL1,IL33,LGALS9,LPL,TLR2,TLR4,TRPV4,CSF1R,DDX3X"]
["GO:BP","positive regulation of MAPK cascade","GO:0043410",{"v":3.16789548981423,"d":"3.17E+00"},539,235,38,18117,"EGFR,AGER,MFHAS1,APOE,APP,NOTCH1,NOTCH2,PIK3CG,C5AR1,FGFR1,FPR1,HAVCR2,HGF,SLAMF1,PJA2,STK39,PRKCA,PRKCZ,NDST1,HMGB1,ICAM1,IGF1,IRAK2,KIT,LGALS9,LRRK2,MAPK14,MAPKAPK2,RASGRP1,THBS1,TLR4,CCL4,CCL5,CD81,TRPV4,CSF1R,CX3CL1,CXCL17"]
["GO:BP","regulation of protein kinase activity","GO:0045859",{"v":3.69325135742851,"d":"3.69E+00"},809,235,46,18117,"EGFR,ACE,ADAM17,AGER,APOE,APP,PDCD4,PIK3CG,C5AR1,FABP4,FGFR1,FPR1,GPRC5B,GSTP1,HGF,SLC11A1,SNCA,SOCS3,STAP1,STK39,PRKCZ,PTPN2,HMGB1,HYAL2,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,TNFAIP3,CSF1,CSF1R,CXCL17,DDX3X"]
["GO:BP","positive regulation of protein modification process","GO:0031401",{"v":3.90132381866776,"d":"3.90E+00"},1074,235,53,18117,"EDNRB,EGFR,ACE,ADAM17,AGER,APP,RPS6KA5,NUPR1,ATM,PIK3CG,BCL6,C5AR1,FGFR1,FPR1,GPRC5B,HGF,C3,SLC11A1,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTGS2,HMGB1,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CDH5,TNIP1,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","positive regulation of kinase activity","GO:0033674",{"v":4.41860366963548,"d":"4.42E+00"},608,235,40,18117,"EGFR,EPHA2,ACE,ADAM17,AGER,AXL,PIK3CG,C5AR1,FGFR1,FPR1,GPRC5B,HGF,SLC11A1,SNCA,STAP1,STK39,PRKCZ,PRKD1,HMGB1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CSF1,CSF1R,CXCL17,DDX3X"]
["GO:BP","regulation of lymphocyte activation","GO:0051249",{"v":0.571661191472333,"d":"5.72E-01"},518,235,37,18117,"AGER,ATM,AXL,BCL6,FANCA,FANCD2,HAVCR2,SIRPA,CAMK4,SPN,STAT5B,PRKCQ,PRKCZ,PTPN2,NFKBID,HMGB1,HSPD1,IDO1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,TLR4,CCL5,CCR2,CD28,CD300A,CD47,CD6,CD81,TNFAIP3,TNFRSF1B,CEBPB,DROSHA"]
["GO:BP","negative regulation of gene expression","GO:0010629",{"v":0.572167771575465,"d":"5.72E-01"},1460,235,62,18117,"EGFR,EIF2AK1,EPHA2,ABCD1,ACE,AGER,APOE,APP,APPL2,SERPINE1,SERPINF1,RPS19,RPS6KA5,NOTCH1,NOTCH2,ATM,AXL,PDCD4,BCL6,FN1,GSTP1,HAVCR2,HDAC9,HGF,SIRPA,SLAMF1,SLC11A1,PPARA,PPARG,STAT3,PRKCA,PSMA1,NFKB1,HMGB1,HMGB2,HMOX1,IDO1,IGF1,IL1R2,IL1RL1,IL33,LDLR,LGALS9,LRRK2,MAPK14,MAPKAPK2,REL,RELB,TGFB1,THBS1,TLR4,CD200,CD28,CD96,TNFAIP3,CMKLR1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DROSHA"]
["GO:BP","cellular response to endogenous stimulus","GO:0071495",{"v":0.687656195780731,"d":"6.88E-01"},1422,235,61,18117,"EGFR,ABCC1,ADAM17,ADAMTS12,AGER,APP,APPL2,SCNN1B,SERPINB9,SERPINF1,NOTCH1,NOTCH2,P2RX7,PDCD4,PDE2A,PIK3CG,FGFR1,GJA1,GSTP1,HDAC9,SLIT2,CASP4,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRCP,PRKCQ,PRKCZ,PTAFR,PTGFR,PTGS2,PTPN2,NDST1,NFKB1,HYAL2,ICAM1,IGF1,ITGB6,JAK2,KIT,LPL,LRRK2,LYN,RARRES2,RBPJ,TCIRG1,TGFB1,THBS1,TLR4,CCL5,CDH5,VPS35,CEBPB,CSRP3,CTSS,CYBB"]
["GO:BP","blood vessel development","GO:0001568",{"v":0.883283143785776,"d":"8.83E-01"},792,235,45,18117,"EDNRA,EPHA2,ALOX5,APOE,SERPINE1,SERPINF1,RORA,NOTCH1,NOTCH2,PDE2A,PIK3CG,C5AR1,F3,FN1,GRN,HDAC9,HGF,C3,SLIT2,CALCRL,PPARG,SOCS3,STAB1,STAT3,PRCP,PRKCA,PRKD1,PTGIS,PTGS2,NDST1,HMGB1,HMOX1,IL18,JAM3,LDLR,MAPK14,RBPJ,TGFB1,THBS1,CCR2,CDH5,TNFAIP3,CX3CL1,CXCL17,CYBB"]
["GO:BP","positive regulation of transferase activity","GO:0051347",{"v":0.954883912469567,"d":"9.55E-01"},689,235,42,18117,"EGFR,EPHA2,ACE,ADAM17,AGER,AXL,PIK3CG,C5AR1,FGFR1,FPR1,GPRC5B,HGF,SLC11A1,SNCA,STAP1,STK39,PRKCQ,PRKCZ,PRKD1,HMGB1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD200,CD300A,CD81,CSF1,CSF1R,CXCL17,DDX3X"]
["GO:BP","adaptive immune response","GO:0002250",{"v":0.954883912469567,"d":"9.55E-01"},689,235,42,18117,"ADAM17,AGER,RORA,PIK3CG,BCL6,FCER1G,HAVCR2,C3,SLAMF1,SLC11A1,CAMK4,PLA2G4A,SPN,STAT3,PRKCQ,PRKCZ,NFKBID,HMGB1,HSPD1,ICAM1,IL17RA,IL18,IL18R1,IL1R1,IL1RL1,IL33,JAK2,JAM3,LYN,RELB,TCIRG1,TGFB1,TLR4,CCR2,CD28,CD6,CD81,TNFAIP3,TNFRSF1B,UNC13D,CTSC,CTSS"]
["GO:BP","ERK1 and ERK2 cascade","GO:0070371",{"v":10.3334735087166,"d":"1.03E+01"},329,235,30,18117,"EGFR,EPHA2,AGER,MFHAS1,APOE,APP,NOTCH1,NOTCH2,C5AR1,FN1,GSTP1,HAVCR2,SIRPA,SLAMF1,PRKCA,PRKCZ,PTPN2,HMGB1,ICAM1,IGF1,LGALS9,LYN,RASGRP1,TLR4,CCL4,CCL5,TNIP1,TRPV4,CSF1R,CX3CL1"]
["GO:BP","metabolic process","GO:0008152",{"v":12.7565524768275,"d":"1.28E+01"},11827,235,209,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AK7,AKNA,ALDH2,ALOX5,ALOX5AP,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL33,IRAK2,ITGAM,ITGB6,JAK2,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRRK2,LXN,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR1,TLR2,TLR4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD6,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TPSB2,TRPV4,UACA,ULK4,VPS35,ZBP1,CEBPB,CERS6,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYBB,CYLD,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","organonitrogen compound metabolic process","GO:1901564",{"v":14.1517313225273,"d":"1.42E+01"},6792,235,151,18117,"MECOM,EDNRB,EGFR,EIF2AK1,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AK7,MFHAS1,APOE,APP,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,F8,FABP4,FGFR1,FN1,FPR1,GJA1,GPRC5B,GPX4,GRN,GSTP1,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL1R2,IL33,IRAK2,ITGAM,JAK2,KIT,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD28,CD300A,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TPSB2,UACA,ULK4,VPS35,CERS6,CIITA,CSF1,CSF1R,CTSC,CTSS,DHX9,CX3CL1,CXCL17,CYLD,DDX3X,DUOXA1,HK1"]
["GO:BP","regulation of protein modification process","GO:0031399",{"v":1.49555422635671,"d":"1.50E+00"},1671,235,66,18117,"EDNRB,EGFR,EIF2AK1,ACE,ADAM17,AGER,MFHAS1,APOE,APP,RPS6KA5,NUPR1,ATM,PDCD4,PIK3CG,BCL6,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCZ,PRKD1,PTGS2,PTPN2,NDUFS4,HMGB1,HYAL2,ICAM1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CDH5,TNFAIP3,TNIP1,CSF1,CSF1R,CX3CL1,CXCL17,DDX3X"]
["GO:BP","regulation of ERK1 and ERK2 cascade","GO:0070372",{"v":16.2681926267966,"d":"1.63E+01"},309,235,29,18117,"EGFR,EPHA2,AGER,MFHAS1,APOE,APP,NOTCH1,NOTCH2,C5AR1,FN1,GSTP1,HAVCR2,SIRPA,SLAMF1,PRKCA,PRKCZ,PTPN2,HMGB1,ICAM1,LGALS9,LYN,RASGRP1,TLR4,CCL4,CCL5,TNIP1,TRPV4,CSF1R,CX3CL1"]
["GO:BP","circulatory system development","GO:0072359",{"v":16.6820870866653,"d":"1.67E+01"},1194,235,55,18117,"EDNRA,EGFR,EPHA2,ALOX5,APOE,SERPINE1,SERPINF1,RORA,NOTCH1,NOTCH2,ATM,PDCD4,PDE2A,PIK3CG,C5AR1,F3,FN1,GJA1,GRN,HDAC9,HGF,C3,SLIT2,CALCRL,PPARA,PPARD,PPARG,SOCS3,STAB1,STAT3,PRCP,PRKCA,PRKD1,PTGIS,PTGS2,NDST1,HMGB1,HMOX1,IGF1,IL18,JAM3,KIT,LDLR,MAPK14,RBPJ,TGFB1,THBS1,CCR2,CDH5,TNFAIP3,TNFRSF1B,CSRP3,CX3CL1,CXCL17,CYBB"]
["GO:BP","positive regulation of interleukin-6 production","GO:0032755",{"v":18.2563202435413,"d":"1.83E+01"},89,235,18,18117,"AGER,APP,STAT3,PTAFR,HMGB1,HSPD1,HYAL2,IL16,IL17RA,IL1RAP,IL33,LGALS9,LPL,TLR1,TLR2,TLR4,TRPV4,DHX9"]
["GO:BP","negative regulation of apoptotic process","GO:0043066",{"v":19.6021359821388,"d":"1.96E+01"},921,235,48,18117,"EDNRB,EGFR,APOE,SERPINB9,SERPINE1,NOTCH1,NOTCH2,NUPR1,AXL,PDCD4,PIK3CG,BCL6,C5AR1,GRN,GSTP1,HCK,HGF,CAMK1D,SNCA,PPARA,PPARD,SOCS3,STAT5B,PRKCA,PRKCQ,PRKCZ,PTGFR,PTGS2,NFKB1,NFKBIA,HMGB2,HMOX1,HSPD1,ICAM1,IDO1,IGF1,JAK2,LRRK2,THBS1,TIMP1,CCL5,CD28,CDH5,TNFAIP3,CEBPB,CSF1R,CX3CL1,DDX3X"]
["GO:BP","positive regulation of chemokine production","GO:0032722",{"v":19.7441116440795,"d":"1.97E+01"},63,235,16,18117,"ADAM17,AGER,APP,HAVCR2,HMGB1,HMOX1,IL17RA,IL1RL1,IL33,LGALS9,LPL,TLR2,TLR4,TRPV4,CSF1R,DDX3X"]
["GO:BP","localization","GO:0051179",{"v":23.2849410517392,"d":"2.33E+01"},6901,235,152,18117,"MCPH1,EDNRA,EDNRB,EGFR,EIF2AK1,EPHA2,ABCC1,ABCD1,ACE,ADAM17,ADAMTS12,AGER,ALOX5,MFHAS1,APOE,APP,APPL2,SCN9A,SCNN1B,SDC1,SERPINE1,SERPINF1,RPS19,NOTCH1,NR1H3,OLR1,P2RX1,P2RX7,ASH1L,ATM,ATRN,AXL,PIK3CG,BCL6,C5AR1,F3,F8,FABP4,FCER1G,FGFR1,FN1,FPR1,GBP5,GJA1,GRN,GSTP1,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLC7A2,SLIT2,CALCRL,CAMK1D,PLA2G4A,PLA2G7,SNAP23,SNCA,PPARA,PPARD,PPARG,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGS2,PTPN2,PXK,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL16,IL1R1,IL33,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD163,CD200,CD300A,CD47,CD6,CD68,CD81,CDH5,TNFAIP3,TNFRSF1B,TRPV4,ULK4,UNC13D,VPS35,CEBPB,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTSC,CTSS,DHX9,CX3CL1,CXCL17,CXCL2,CYBB,CYSLTR1,DDX3X,DUOXA1,HK1"]
["GO:BP","positive regulation of leukocyte cell-cell adhesion","GO:1903039",{"v":2.34687867461833,"d":"2.35E+00"},241,235,26,18117,"AGER,ALOX5,BCL6,HAVCR2,SIRPA,STAT5B,PRKCQ,PRKCZ,PTAFR,NFKBID,HMGB1,HSPD1,ICAM1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,CCL5,CCR2,CD28,CD47,CD6,CD81"]
["GO:BP","blood vessel morphogenesis","GO:0048514",{"v":2.79851146782275,"d":"2.80E+00"},711,235,42,18117,"EDNRA,EPHA2,ALOX5,APOE,SERPINE1,SERPINF1,RORA,NOTCH1,NOTCH2,PIK3CG,C5AR1,F3,FN1,GRN,HDAC9,HGF,C3,SLIT2,CALCRL,PPARG,STAB1,STAT3,PRCP,PRKCA,PRKD1,PTGIS,PTGS2,HMGB1,HMOX1,IL18,JAM3,LDLR,MAPK14,RBPJ,TGFB1,THBS1,CCR2,CDH5,TNFAIP3,CX3CL1,CXCL17,CYBB"]
["GO:BP","vesicle-mediated transport","GO:0016192",{"v":31.2209123889559,"d":"3.12E+01"},2180,235,76,18117,"EGFR,EIF2AK1,AGER,ALOX5,APOE,APP,APPL2,SDC1,SERPINE1,NOTCH1,NR1H3,OLR1,P2RX1,AXL,PIK3CG,C5AR1,F8,FCER1G,FN1,FPR1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLAMF1,SLC11A1,CALCRL,CAMK1D,SNAP23,SNCA,PPARG,STAB1,STAP1,PRCP,PRKD1,PTAFR,PTGDR,NFKB1,HMGB1,HMOX1,IGF1,ITGAM,KIT,LDLR,LGALS9,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CCR2,CD163,CD300A,CD47,CD6,CD68,CD81,TNFRSF1B,UNC13D,VPS35,CTSC,CTSS,CYBB,DDX3X"]
["GO:BP","lymphocyte proliferation","GO:0046651",{"v":3.81012397376955,"d":"3.81E+00"},294,235,28,18117,"AGER,ATM,PIK3CG,BCL6,HAVCR2,SLC11A1,SPN,STAT5B,PRKCQ,HMGB1,HSPD1,IDO1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,TLR4,CCL5,CCR2,CD28,CD300A,CD6,CD81,TNFRSF1B,CEBPB"]
["GO:BP","toll-like receptor signaling pathway","GO:0002224",{"v":3.834245550817,"d":"3.83E+00"},161,235,22,18117,"MFHAS1,APPL2,NR1H3,PIK3AP1,HAVCR2,PJA2,NFKBIA,HMGB1,HSPD1,IRAK2,ITGAM,LY96,LYN,MAPKAPK2,TLR1,TLR2,TLR4,CD300A,TNFAIP3,TNIP1,CTSS,DDX3X"]
["GO:BP","positive regulation of leukocyte chemotaxis","GO:0002690",{"v":4.04707409118243,"d":"4.05E+00"},93,235,18,18117,"ADAM17,SERPINE1,C5AR1,CAMK1D,PLA2G7,STK39,HMGB1,LGALS9,RARRES2,THBS1,CCL4,CCL5,CCR2,TRPV4,CMKLR1,CSF1,CSF1R,CXCL17"]
["GO:BP","angiogenesis","GO:0001525",{"v":4.12971775138467,"d":"4.13E+00"},617,235,39,18117,"EDNRA,EPHA2,ALOX5,SERPINE1,SERPINF1,RORA,NOTCH1,NOTCH2,PIK3CG,C5AR1,F3,FN1,GRN,HDAC9,HGF,C3,SLIT2,CALCRL,PPARG,STAB1,STAT3,PRCP,PRKCA,PRKD1,PTGIS,PTGS2,HMGB1,HMOX1,IL18,JAM3,MAPK14,RBPJ,THBS1,CCR2,CDH5,TNFAIP3,CX3CL1,CXCL17,CYBB"]
["GO:BP","interleukin-1 production","GO:0032612",{"v":4.72874827419398,"d":"4.73E+00"},126,235,20,18117,"AGER,AIM2,APP,P2RX7,GBP5,GSTP1,HAVCR2,SIRPA,STAT3,HMGB1,IGF1,IL16,IL1R2,JAK2,LGALS9,LPL,TLR4,TNFAIP3,CX3CL1,HK1"]
["GO:BP","lymphocyte differentiation","GO:0030098",{"v":4.83957533191958,"d":"4.84E+00"},376,235,31,18117,"ADAM17,RORA,NOTCH2,ATM,AXL,BCL6,FANCA,FANCD2,FCER1G,HDAC9,CAMK4,SPN,STAT3,STAT5B,PRKCZ,PTPN2,NFKBID,HMGB1,IL18,IL18R1,IL2RA,KIT,LGALS9,RASGRP1,RBPJ,RELB,TCIRG1,TGFB1,CCR2,CD28,DROSHA"]
["GO:BP","tube morphogenesis","GO:0035239",{"v":6.32992638310879,"d":"6.33E+00"},950,235,48,18117,"EDNRA,EPHA2,ADAMTS12,ALOX5,APOE,SERPINE1,SERPINF1,RORA,NOTCH1,NOTCH2,PIK3CG,C5AR1,F3,FN1,GRN,HDAC9,HGF,C3,SLIT2,CALCRL,PPARG,STAB1,STAT3,PRCP,PRKCA,PRKD1,PTGIS,PTGS2,HMGB1,HMOX1,IL18,JAM3,LDLR,MAPK14,RBPJ,TGFB1,TGM2,THBS1,CCR2,CDH5,TNFAIP3,CSF1,CSF1R,CTNNBIP1,DICER1,CX3CL1,CXCL17,CYBB"]
["GO:BP","multicellular organismal homeostasis","GO:0048871",{"v":7.17386100950757,"d":"7.17E+00"},530,235,36,18117,"EDNRB,EGFR,ADAM17,METRNL,APPL2,SCNN1B,NOTCH1,NR1H3,P2RX7,FABP4,GJA1,SLC11A1,STAT3,STK39,PRCP,PRKCA,PTGS2,HYAL2,IL18,IL18R1,ITGB6,JAK2,JAM3,LIPA,RBPJ,TCIRG1,TGFB1,TLR4,CCR2,CDH5,TNFAIP3,TRPV4,CEBPB,CMKLR1,CSF1,CSF1R"]
["GO:BP","macrophage migration","GO:1905517",{"v":7.34752878488773,"d":"7.35E+00"},56,235,15,18117,"EDNRB,C5AR1,STAP1,RARRES2,THBS1,CCL5,CCR2,CD200,CD81,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","negative regulation of metabolic process","GO:0009892",{"v":0.896047773726348,"d":"8.96E-01"},3479,235,99,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,ADAM17,AGER,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,SERPINF1,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,AXL,PDCD4,PDE2A,PIK3CG,BCL6,FABP4,FN1,GJA1,GRN,GSTP1,HAVCR2,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,PRKCA,PRKCZ,PSMA1,PTGIS,PTGS2,PTPN2,NFKB1,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,IDO1,IGF1,IL18R1,IL1R2,IL1RL1,IL33,ITGAM,LDLR,LGALS9,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,THBS1,TIMP1,TLR4,CD200,CD28,CD300A,CD96,TNFAIP3,TRPV4,CEBPB,CIITA,CMKLR1,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DROSHA"]
["GO:BP","positive regulation of protein kinase activity","GO:0045860",{"v":8.98317759353691,"d":"8.98E+00"},534,235,36,18117,"EGFR,ACE,ADAM17,AGER,PIK3CG,C5AR1,FGFR1,FPR1,GPRC5B,HGF,SLC11A1,SNCA,STAP1,STK39,PRKCZ,HMGB1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CCL5,CD300A,CD81,CSF1,CSF1R,CXCL17,DDX3X"]
["GO:BP","response to hormone","GO:0009725",{"v":9.16598385673793,"d":"9.17E+00"},921,235,47,18117,"EDNRB,EGFR,APPL2,SCNN1B,SDC1,SERPINB9,SERPINF1,NOTCH1,NR1H3,GJA1,GSTP1,HDAC9,SLIT2,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRCP,PRKCQ,PRKCZ,PTAFR,PTGFR,PTGS2,PTPN2,NFKB1,HMGB1,HMGB2,HMOX1,HSPD1,ICAM1,JAK2,KIT,LPL,LYN,RARRES2,TCIRG1,TGFB1,THBS1,TIMP1,TLR2,TRPV4,CSRP3,CTSS,CYBB"]
["GO:BP","regulation of mononuclear cell proliferation","GO:0032944",{"v":9.16598385673793,"d":"9.17E+00"},232,235,25,18117,"AGER,ATM,BCL6,HAVCR2,SPN,STAT5B,PRKCQ,HMGB1,IDO1,IGF1,IL18,IL2RA,LGALS9,LYN,TGFB1,TLR4,CCL5,CCR2,CD28,CD300A,CD6,CD81,TNFRSF1B,CEBPB,CSF1"]
["GO:BP","anatomical structure formation involved in morphogenesis","GO:0048646",{"v":9.20861149562476,"d":"9.21E+00"},1202,235,54,18117,"EDNRA,EPHA2,ADAM17,ALOX5,SERPINE1,SERPINF1,RORA,NOTCH1,NOTCH2,ATM,PIK3CG,BCL6,C5AR1,F3,FN1,GJA1,GRN,HDAC9,HGF,C3,SLIT2,CALCRL,PMP22,PPARA,PPARG,STAB1,STAT3,PRCP,PRKCA,PRKD1,PTGIS,PTGS2,HMGB1,HMOX1,IL18,ITGB6,JAM3,MAPK14,RBPJ,TCIRG1,TGFB1,TGM2,THBS1,TLR2,CCR2,CD81,CDH5,TNFAIP3,UNC13D,CSRP3,DICER1,CX3CL1,CXCL17,CYBB"]
["GO:BP","granulocyte activation","GO:0036230",{"v":9.59560061181765,"d":"9.60E+00"},504,235,35,18117,"ENPP3,ALOX5,OLR1,P2RX1,C5AR1,FCER1G,FPR1,GRN,GSTP1,C3,SIRPA,SLC11A1,SNAP23,PRCP,PTAFR,NFKB1,HMGB1,IL18,IL18RAP,ITGAM,MAPK14,TCIRG1,TLR2,CCL5,CCR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X,DNASE1"]
["GO:BP","myeloid leukocyte differentiation","GO:0002573",{"v":130.606287175472,"d":"1.31E+02"},213,235,24,18117,"EIF2AK1,EPHA2,APP,NOTCH2,PDE2A,CAMK4,PPARG,PRKCA,PTPN2,ITGB6,KIT,LYN,MAPK14,RBPJ,RELB,TCIRG1,TGFB1,TLR2,TLR4,CD81,CEBPB,CSF1,CSF1R,CTNNBIP1"]
["GO:BP","regulation of neuroinflammatory response","GO:0150077",{"v":134.340173853983,"d":"1.34E+02"},47,235,14,18117,"NUPR1,ATM,GRN,STAP1,PTGS2,IGF1,IL18,IL33,LDLR,LRRK2,CD200,TNFRSF1B,CTSC,CX3CL1"]
["GO:BP","positive regulation of cell-cell adhesion","GO:0022409",{"v":134.340173853983,"d":"1.34E+02"},284,235,27,18117,"AGER,ALOX5,BCL6,HAVCR2,SIRPA,STAT5B,PRKCQ,PRKCZ,PTAFR,NFKBID,HMGB1,HSPD1,ICAM1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,CCL5,CCR2,CD28,CD47,CD6,CD81,CX3CL1"]
["GO:BP","T cell differentiation","GO:0030217",{"v":140.120273110451,"d":"1.40E+02"},260,235,26,18117,"ADAM17,RORA,BCL6,FANCA,FANCD2,FCER1G,CAMK4,SPN,STAT3,STAT5B,PRKCZ,PTPN2,NFKBID,HMGB1,IL18,IL18R1,IL2RA,KIT,LGALS9,RASGRP1,RELB,TCIRG1,TGFB1,CCR2,CD28,DROSHA"]
["GO:BP","regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains","GO:0002822",{"v":142.892664990036,"d":"1.43E+02"},152,235,21,18117,"AGER,BCL6,HAVCR2,C3,SLC11A1,PLA2G4A,PRKCQ,PRKCZ,NFKBID,HMGB1,HSPD1,IL18,IL18R1,IL1R1,IL1RL1,IL33,CCR2,CD28,CD81,TNFAIP3,TNFRSF1B"]
["GO:BP","response to interleukin-1","GO:0070555",{"v":159.017989340018,"d":"1.59E+02"},215,235,24,18117,"ADAMTS12,APP,RORA,RPS6KA5,SIRPA,SNCA,PRKCA,PSMA1,PTGIS,NFKB1,NFKBIA,HYAL2,ICAM1,IL1R1,IL1R2,IL1RAP,IRAK2,LGALS9,CCL4,CCL5,CD47,ZBP1,CEBPB,CX3CL1"]
["GO:BP","regulation of hemopoiesis","GO:1903706",{"v":18.2838594324734,"d":"1.83E+01"},424,235,32,18117,"AGER,NOTCH2,AXL,BCL6,FANCA,FANCD2,CAMK4,STAT3,STAT5B,PRKCA,PRKCQ,PRKCZ,PTPN2,NFKBIA,NFKBID,HMGB1,HMGB2,IL18,IL2RA,LGALS9,LYN,MAPK14,RASGRP1,TGFB1,THBS1,TLR4,CCR2,CD28,CEBPB,CSF1,CTNNBIP1,DROSHA"]
["GO:BP","regulation of interleukin-1 production","GO:0032652",{"v":22.894899236051,"d":"2.29E+01"},119,235,19,18117,"AGER,AIM2,APP,P2RX7,GSTP1,HAVCR2,SIRPA,STAT3,HMGB1,IGF1,IL16,IL1R2,JAK2,LGALS9,LPL,TLR4,TNFAIP3,CX3CL1,HK1"]
["GO:BP","anatomical structure morphogenesis","GO:0009653",{"v":250.718406248954,"d":"2.51E+02"},2797,235,86,18117,"EDNRA,EGFR,ELF3,EPHA2,ADAM17,ADAMTS12,ALOX5,APOE,APP,SDC1,SERPINE1,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,ASH1L,ATM,ATRN,AXL,PDCD4,PIK3CG,BCL6,C5AR1,F3,FANCD2,FGFR1,FN1,GJA1,GRN,HCK,HDAC9,HGF,C3,SLIT2,CALCRL,PMP22,PPARA,PPARG,SOCS3,STAB1,STAT3,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGIS,PTGS2,NDST1,HMGB1,HMOX1,HYAL2,ICAM1,IL18,ITGB6,JAM3,KIT,LDLR,LIPA,LRRK2,MAPK14,RBPJ,TCIRG1,TGFB1,TGM2,THBS1,TLR2,CCR2,CD81,CDH5,TNFAIP3,TNFRSF1B,TRPV4,UNC13D,VPS35,CEBPB,CSF1,CSF1R,CSRP3,CTNNBIP1,DICER1,CX3CL1,CXCL17,CYBB"]
["GO:BP","epithelial cell proliferation","GO:0050673",{"v":27.1300715872185,"d":"2.71E+01"},460,235,33,18117,"EDNRB,EGFR,EPHA2,ADAM17,ALOX5,APOE,SERPINF1,NOTCH1,NOTCH2,NUPR1,C5AR1,F3,FGFR1,GJA1,GRN,HGF,PPARD,PPARG,STAT3,STAT5A,PRKCA,PRKD1,HMGB1,HMGB2,HMOX1,IGF1,KIT,RICTOR,TGFB1,THBS1,TLR4,TNFAIP3,CEBPB"]
["GO:BP","negative regulation of immune response","GO:0050777",{"v":273.709062372657,"d":"2.74E+02"},157,235,21,18117,"ENPP3,SERPINB9,RPS19,NR1H3,BCL6,GRN,HAVCR2,PPARG,PSMA1,PTPN2,HMOX1,IL1RL1,IL2RA,IL33,LGALS9,LYN,TGFB1,CCR2,CD300A,CD96,TNFAIP3"]
["GO:BP","positive regulation of DNA-binding transcription factor activity","GO:0051091",{"v":341.15260562582,"d":"3.41E+02"},270,235,26,18117,"AGER,AIM2,APP,RPS6KA5,CAMK1D,PPARG,STAT3,PRKCQ,PRKCZ,PRKD1,NFKB1,ICAM1,IL18,IL18R1,IL18RAP,IL1RAP,IRAK2,JAK2,KIT,LGALS9,TGFB1,TLR2,TLR4,CD200,DHX9,CX3CL1"]
["GO:BP","positive regulation of transport","GO:0051050",{"v":458.501287252717,"d":"4.59E+02"},923,235,46,18117,"EDNRB,EGFR,APOE,APPL2,SDC1,SERPINE1,NR1H3,P2RX1,P2RX7,AXL,FCER1G,GJA1,C3,SIRPA,SLC11A1,CAMK1D,PLA2G4A,SNCA,PPARD,PPARG,STAP1,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,NFKBIA,HYAL2,IGF1,ITGAM,JAK2,LPCAT3,LRRK2,MAPK14,TLR2,TLR4,CCL4,CCL5,CCR2,CD47,CD81,UNC13D,CEBPB,CTSS,DHX9,CX3CL1"]
["GO:BP","neuroinflammatory response","GO:0150076",{"v":466.72786297877,"d":"4.67E+02"},51,235,14,18117,"NUPR1,ATM,GRN,STAP1,PTGS2,IGF1,IL18,IL33,LDLR,LRRK2,CD200,TNFRSF1B,CTSC,CX3CL1"]
["GO:BP","positive regulation of response to biotic stimulus","GO:0002833",{"v":504.002577166554,"d":"5.04E+02"},250,235,25,18117,"AIM2,RPS19,RPS6KA5,FCER1G,GBP5,GRN,HAVCR2,HCK,STAT5B,PRKCA,PSMA1,NFKB1,HMGB1,HMGB2,HSPD1,IL18RAP,LY86,LY96,LYN,RASGRP1,RELB,TLR4,CCL5,ZBP1,DHX9"]
["GO:BP","positive regulation of NF-kappaB transcription factor activity","GO:0051092",{"v":51.3596327279357,"d":"5.14E+01"},162,235,21,18117,"AGER,AIM2,APP,RPS6KA5,STAT3,PRKCQ,PRKCZ,PRKD1,NFKB1,ICAM1,IL18,IL18R1,IL18RAP,IL1RAP,IRAK2,LGALS9,TGFB1,TLR2,TLR4,DHX9,CX3CL1"]
["GO:BP","regulation of lymphocyte proliferation","GO:0050670",{"v":71.3090067258251,"d":"7.13E+01"},230,235,24,18117,"AGER,ATM,BCL6,HAVCR2,SPN,STAT5B,PRKCQ,HMGB1,IDO1,IGF1,IL18,IL2RA,LGALS9,LYN,TGFB1,TLR4,CCL5,CCR2,CD28,CD300A,CD6,CD81,TNFRSF1B,CEBPB"]
["GO:BP","inflammatory response to antigenic stimulus","GO:0002437",{"v":77.6789559191136,"d":"7.77E+01"},65,235,15,18117,"NOTCH1,NOTCH2,C3,PSMA1,HMGB1,HMGB2,ICAM1,IL2RA,RASGRP1,RBPJ,CD28,CD6,CD68,CD81,CYSLTR1"]
["GO:BP","regulation of macrophage migration","GO:1905521",{"v":80.9786057962035,"d":"8.10E+01"},42,235,13,18117,"C5AR1,STAP1,RARRES2,THBS1,CCL5,CD200,CD81,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","regulation of adaptive immune response","GO:0002819",{"v":94.5402008996184,"d":"9.45E+01"},167,235,21,18117,"AGER,BCL6,HAVCR2,C3,SLC11A1,PLA2G4A,PRKCQ,PRKCZ,NFKBID,HMGB1,HSPD1,IL18,IL18R1,IL1R1,IL1RL1,IL33,CCR2,CD28,CD81,TNFAIP3,TNFRSF1B"]
["GO:BP","wound healing","GO:0042060",{"v":1197.56207323856,"d":"1.20E+03"},549,235,35,18117,"EGFR,ADAM17,AGER,ALOX5,APOE,SDC1,SERPINE1,NOTCH2,P2RX1,P2RX7,AXL,PIK3CG,F3,F8,FCER1G,FN1,GJA1,SLC11A1,PLA2G4A,PPARA,PPARD,PRCP,PRKCA,PRKCQ,HMGB1,HMOX1,IGF1,JAK2,LYN,TGFB1,THBS1,TIMP1,TLR4,TNFAIP3,CX3CL1"]
["GO:BP","pattern recognition receptor signaling pathway","GO:0002221",{"v":1286.71574178636,"d":"1.29E+03"},213,235,23,18117,"MFHAS1,APPL2,NR1H3,PIK3AP1,HAVCR2,PJA2,NFKBIA,HMGB1,HSPD1,IRAK2,ITGAM,LY96,LYN,MAPKAPK2,TLR1,TLR2,TLR4,CD300A,TNFAIP3,TNIP1,CTSS,CYLD,DDX3X"]
["GO:BP","homeostasis of number of cells","GO:0048872",{"v":1341.63739268172,"d":"1.34E+03"},261,235,25,18117,"ADAM17,MFHAS1,RPS19,NOTCH1,AXL,BCL6,STAT3,STAT5B,PTPN2,HMGB1,HMGB2,HMOX1,IL2RA,JAK2,JAM3,KIT,LGALS9,LIPA,LPCAT3,LYN,MAPK14,TCIRG1,TGFB1,TNFAIP3,CSF1"]
["GO:BP","cellular response to nitrogen compound","GO:1901699",{"v":1348.24466720634,"d":"1.35E+03"},724,235,40,18117,"ABCC1,AGER,APP,APPL2,P2RX7,PDE2A,PIK3CG,GJA1,GSTP1,HDAC9,SLIT2,CASP4,SNCA,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PTAFR,PTGS2,PTPN2,NFKB1,ICAM1,IGF1,JAK2,LPL,LRRK2,LYN,RARRES2,TCIRG1,TGFB1,TLR4,VPS35,CEBPB,CIITA,CSRP3,DHX9,CYBB"]
["GO:BP","regulation of leukocyte differentiation","GO:1902105",{"v":1541.5249913287,"d":"1.54E+03"},288,235,26,18117,"AGER,NOTCH2,AXL,BCL6,FANCA,FANCD2,CAMK4,STAT5B,PRKCA,PRKCZ,PTPN2,NFKBID,HMGB1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,TLR4,CCR2,CD28,CEBPB,CSF1,CTNNBIP1,DROSHA"]
["GO:BP","regulation of lymphocyte mediated immunity","GO:0002706",{"v":1541.5249913287,"d":"1.54E+03"},151,235,20,18117,"AGER,SERPINB9,BCL6,HAVCR2,C3,STAT5B,PRKCZ,HMGB1,HSPD1,IL18,IL18R1,IL18RAP,IL1R1,LGALS9,RASGRP1,CCR2,CD28,CD81,CD96,TNFRSF1B"]
["GO:BP","T-helper 1 type immune response","GO:0042088",{"v":1567.76951515557,"d":"1.57E+03"},44,235,13,18117,"HAVCR2,SLC11A1,PLA2G4A,SPN,HMGB1,IL18,IL18R1,IL1R1,IL1RL1,IL33,RELB,TLR4,CCR2"]
["GO:BP","negative regulation of cell communication","GO:0010648",{"v":162.829267321798,"d":"1.63E+02"},1468,235,58,18117,"MECOM,EGFR,EPHA2,ADAM17,ADAMTS12,AGER,MFHAS1,APOE,SERPINE1,RORA,NOTCH1,NR1H3,P2RX7,ASH1L,ATM,PDCD4,PDE2A,BCL6,GJA1,GSTP1,HGF,SIRPA,SLAMF1,SLIT2,SNCA,PPARA,PPARG,SOCS3,STAP1,PRKCQ,PRKCZ,PSMA1,PTGS2,PTPN2,NFKBIA,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL1R2,LRRK2,LY96,LYN,MAPK14,THBS1,TLR4,CCL5,CD300A,CD47,TNFAIP3,TNIP1,UACA,CNR2,CTNNBIP1,CX3CL1,CYLD,DDX3X"]
["GO:BP","negative regulation of signaling","GO:0023057",{"v":1771.27581351925,"d":"1.77E+03"},1471,235,58,18117,"MECOM,EGFR,EPHA2,ADAM17,ADAMTS12,AGER,MFHAS1,APOE,SERPINE1,RORA,NOTCH1,NR1H3,P2RX7,ASH1L,ATM,PDCD4,PDE2A,BCL6,GJA1,GSTP1,HGF,SIRPA,SLAMF1,SLIT2,SNCA,PPARA,PPARG,SOCS3,STAP1,PRKCQ,PRKCZ,PSMA1,PTGS2,PTPN2,NFKBIA,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL1R2,LRRK2,LY96,LYN,MAPK14,THBS1,TLR4,CCL5,CD300A,CD47,TNFAIP3,TNIP1,UACA,CNR2,CTNNBIP1,CX3CL1,CYLD,DDX3X"]
["GO:BP","interferon-gamma production","GO:0032609",{"v":1771.27581351925,"d":"1.77E+03"},115,235,18,18117,"AXL,HAVCR2,SIRPA,SLC11A1,SPN,HMGB1,HSPD1,IL18,IL18R1,IL1R1,IL1RL1,IL33,LGALS9,RASGRP1,TLR4,CCR2,CD47,CD96"]
["GO:BP","positive regulation of T cell activation","GO:0050870",{"v":228.918959066735,"d":"2.29E+02"},219,235,23,18117,"AGER,BCL6,HAVCR2,SIRPA,STAT5B,PRKCQ,PRKCZ,NFKBID,HMGB1,HSPD1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,CCL5,CCR2,CD28,CD47,CD6,CD81"]
["GO:BP","response to organic cyclic compound","GO:0014070",{"v":240.704588016727,"d":"2.41E+02"},967,235,46,18117,"EDNRB,EGFR,APP,SCNN1B,SDC1,SERPINF1,RORA,NOTCH1,NR1H3,P2RX1,P2RX7,PDE2A,PIK3CG,GJA1,GPX4,GSTP1,SLIT2,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5B,PTAFR,PTGFR,PTGS2,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HSPD1,ICAM1,IL18,JAK2,LRRK2,LYN,TGFB1,THBS1,TLR2,CCL5,VPS35,CEBPB,CIITA,DHX9,CYBB"]
["GO:BP","regulation of response to cytokine stimulus","GO:0060759",{"v":2444.3337039208,"d":"2.44E+03"},197,235,22,18117,"ADAM17,NR1H3,AXL,GSTP1,SLIT2,CASP4,PPARG,SOCS3,STAP1,PTPN2,IL1R1,IL1R2,IRAK2,JAK2,TLR2,TLR4,CCL5,TNFAIP3,ZBP1,CSF1,DHX9,CYLD"]
["GO:BP","cellular response to organonitrogen compound","GO:0071417",{"v":244.552991506575,"d":"2.45E+02"},666,235,38,18117,"ABCC1,AGER,APP,APPL2,P2RX7,PDE2A,PIK3CG,GJA1,GSTP1,HDAC9,SLIT2,CASP4,SNCA,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PTAFR,PTGS2,PTPN2,NFKB1,ICAM1,IGF1,JAK2,LPL,LRRK2,LYN,RARRES2,TCIRG1,TGFB1,TLR4,VPS35,CEBPB,CSRP3,CYBB"]
["GO:BP","neutrophil activation","GO:0042119",{"v":246.154368584486,"d":"2.46E+02"},498,235,33,18117,"ALOX5,OLR1,P2RX1,C5AR1,FCER1G,FPR1,GRN,GSTP1,C3,SIRPA,SLC11A1,SNAP23,PRCP,PTAFR,NFKB1,HMGB1,IL18,IL18RAP,ITGAM,MAPK14,TCIRG1,TLR2,CCL5,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X,DNASE1"]
["GO:BP","apoptotic signaling pathway","GO:0097190",{"v":2875.96261922012,"d":"2.88E+03"},600,235,36,18117,"EPHA2,SERPINE1,NUPR1,P2RX7,ATM,SGMS1,FGFR1,GSTP1,HGF,CASP4,PPARD,PRKCA,PTGIS,PTGS2,PTPN2,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL33,ITGAM,JAK2,LRRK2,LY96,THBS1,TLR4,CD28,TNFAIP3,TNFRSF1B,UACA,CEBPB,CTSC,CX3CL1,CYLD,DDX3X"]
["GO:BP","response to wounding","GO:0009611",{"v":353.779622898299,"d":"3.54E+02"},674,235,38,18117,"EGFR,ADAM17,AGER,ALOX5,APOE,SDC1,SERPINE1,NOTCH2,P2RX1,P2RX7,AXL,PIK3CG,F3,F8,FCER1G,FN1,GJA1,GRN,SLC11A1,PLA2G4A,PPARA,PPARD,PRCP,PRKCA,PRKCQ,HMGB1,HMOX1,IGF1,JAK2,JAM3,LYN,TGFB1,THBS1,TIMP1,TLR4,CCR2,TNFAIP3,CX3CL1"]
["GO:BP","negative regulation of signal transduction","GO:0009968",{"v":4031.94006924594,"d":"4.03E+03"},1364,235,55,18117,"MECOM,EGFR,EPHA2,ADAM17,ADAMTS12,MFHAS1,APOE,SERPINE1,RORA,NOTCH1,NR1H3,P2RX7,ASH1L,ATM,PDCD4,PDE2A,BCL6,GSTP1,HGF,SIRPA,SLAMF1,SLIT2,SNCA,PPARA,PPARG,SOCS3,STAP1,PRKCQ,PRKCZ,PSMA1,PTGS2,PTPN2,NFKBIA,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL1R2,LRRK2,LY96,LYN,MAPK14,THBS1,TLR4,CCL5,CD300A,CD47,TNFAIP3,TNIP1,UACA,CTNNBIP1,CX3CL1,CYLD,DDX3X"]
["GO:BP","regulation of hydrolase activity","GO:0051336",{"v":420.15028742561,"d":"4.20E+02"},1321,235,54,18117,"EDNRA,EGFR,EPHA2,ABR,AGER,AIM2,APP,SERPINB9,SERPINE1,SERPINF1,NR1H3,P2RX1,BCL6,BCR,C5AR1,F3,FGFR1,FN1,GRN,HDAC9,HGF,C3,SLIT2,SNCA,PPARG,STAT3,PRKCZ,PRKD1,PTAFR,PTGS2,PXK,HMGB1,HMGB2,HSPD1,ICAM1,JAK2,KIT,LGALS9,LPL,LRRK2,LXN,LYN,RASGRP1,RICTOR,THBS1,TIMP1,CCL4,CCL5,CD200,CD300A,UACA,DHX9,CX3CL1,DDX3X"]
["GO:BP","nervous system development","GO:0007399",{"v":4516.29067003062,"d":"4.52E+03"},2449,235,77,18117,"MCPH1,EDNRA,EDNRB,EGFR,EPHA2,ABCD1,ACER3,AGER,AKNA,APOE,APP,APPL2,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,ATM,ATRN,AXL,BCL6,C5AR1,FANCD2,FGFR1,FN1,GJA1,GPRC5B,GRN,GSTP1,HDAC9,HGF,C3,SLIT2,CAMK1D,PMP22,SNCA,PPARD,PPARG,STAP1,STAT3,PRKCA,PRKCQ,PRKCZ,PRKD1,NDST1,NDUFS4,HMGB1,HMGB2,IL1RAP,IL33,ITGAM,JAK2,JAM3,KIT,LDLR,LRFN5,LRRK2,LYN,RBPJ,TBC1D23,TCIRG1,TGFB1,TLR2,TLR4,CCR2,TNFRSF1B,TRPV4,ULK4,VPS35,CEBPB,CSF1,CSF1R,CTSC,DICER1,CX3CL1,DAGLB,DUOXA1"]
["GO:BP","regulation of interleukin-12 production","GO:0032655",{"v":515.31673567681,"d":"5.15E+02"},60,235,14,18117,"AGER,SLAMF1,NFKB1,HMGB1,HSPD1,IDO1,IL16,LGALS9,MAPK14,THBS1,TLR2,TLR4,CD47,CMKLR1"]
["GO:BP","interleukin-12 production","GO:0032615",{"v":515.31673567681,"d":"5.15E+02"},60,235,14,18117,"AGER,SLAMF1,NFKB1,HMGB1,HSPD1,IDO1,IL16,LGALS9,MAPK14,THBS1,TLR2,TLR4,CD47,CMKLR1"]
["GO:BP","T cell proliferation","GO:0042098",{"v":545.213428215723,"d":"5.45E+02"},205,235,22,18117,"AGER,PIK3CG,HAVCR2,SLC11A1,SPN,STAT5B,PRKCQ,HMGB1,IDO1,IGF1,IL18,IL2RA,LGALS9,RASGRP1,TGFB1,CCL5,CCR2,CD28,CD6,CD81,TNFRSF1B,CEBPB"]
["GO:BP","interleukin-1 beta production","GO:0032611",{"v":743.658342804389,"d":"7.44E+02"},107,235,17,18117,"AGER,AIM2,APP,P2RX7,GBP5,GSTP1,SIRPA,STAT3,HMGB1,IGF1,JAK2,LGALS9,LPL,TLR4,TNFAIP3,CX3CL1,HK1"]
["GO:BP","macrophage chemotaxis","GO:0048246",{"v":948.133918533407,"d":"9.48E+02"},39,235,12,18117,"EDNRB,C5AR1,STAP1,RARRES2,THBS1,CCL5,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","lymphocyte activation involved in immune response","GO:0002285",{"v":11839.6533609171,"d":"1.18E+04"},190,235,21,18117,"RORA,NOTCH2,BCL6,FCER1G,HAVCR2,SLC11A1,SPN,STAT3,PRKCZ,NFKBID,HMGB1,HSPD1,ICAM1,IL18,IL18R1,LGALS9,RELB,TLR4,CD28,CD81,UNC13D"]
["GO:BP","regulation of interferon-gamma production","GO:0032649",{"v":11839.6533609171,"d":"1.18E+04"},110,235,17,18117,"AXL,HAVCR2,SIRPA,SLC11A1,HMGB1,HSPD1,IL18,IL18R1,IL1R1,IL1RL1,IL33,LGALS9,RASGRP1,TLR4,CCR2,CD47,CD96"]
["GO:BP","regulation of epithelial cell proliferation","GO:0050678",{"v":11943.2892316251,"d":"1.19E+04"},401,235,29,18117,"EDNRB,EGFR,ADAM17,ALOX5,APOE,SERPINF1,NOTCH1,NOTCH2,NUPR1,C5AR1,F3,FGFR1,GJA1,GRN,PPARD,PPARG,STAT3,STAT5A,PRKCA,PRKD1,HMGB1,HMGB2,HMOX1,IGF1,RICTOR,TGFB1,THBS1,TLR4,TNFAIP3"]
["GO:BP","neutrophil mediated immunity","GO:0002446",{"v":1363.91957451816,"d":"1.36E+03"},497,235,32,18117,"ACE,ADAM17,ALOX5,OLR1,P2RX1,C5AR1,FCER1G,FPR1,GRN,GSTP1,C3,SIRPA,SLC11A1,SNAP23,PRCP,PTAFR,NFKB1,HMGB1,ITGAM,MAPK14,TCIRG1,TLR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X,DNASE1"]
["GO:BP","reactive oxygen species metabolic process","GO:0072593",{"v":13952.6697229697,"d":"1.40E+04"},290,235,25,18117,"EGFR,ABCD1,ALOX5,RORA,GSTP1,SIRPA,SNCA,PPARA,STAT3,PRCP,PTGIS,PTGS2,NDUFS4,HSPD1,ICAM1,ITGAM,JAK2,LRRK2,MAPK14,THBS1,TLR2,TLR4,CD47,CYBB,DUOXA1"]
["GO:BP","positive regulation of ERK1 and ERK2 cascade","GO:0070374",{"v":14318.6427912459,"d":"1.43E+04"},215,235,22,18117,"EGFR,AGER,MFHAS1,APOE,APP,NOTCH1,NOTCH2,C5AR1,HAVCR2,SLAMF1,PRKCA,PRKCZ,HMGB1,ICAM1,LGALS9,RASGRP1,TLR4,CCL4,CCL5,TRPV4,CSF1R,CX3CL1"]
["GO:BP","positive regulation of mononuclear cell migration","GO:0071677",{"v":16590.7864981463,"d":"1.66E+04"},65,235,14,18117,"ADAM17,AGER,APP,SERPINE1,PLA2G7,SPN,STK39,HMGB1,LGALS9,TGFB1,CCL4,CCL5,CCR2,CXCL17"]
["GO:BP","negative regulation of macromolecule metabolic process","GO:0010605",{"v":17312.3990023423,"d":"1.73E+04"},3241,235,90,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABCD1,ACE,AGER,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,SERPINF1,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,ATM,AXL,PDCD4,PDE2A,BCL6,FABP4,FN1,GJA1,GSTP1,HAVCR2,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLIT2,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT3,PRKCA,PRKCZ,PSMA1,PTGS2,PTPN2,NFKB1,HMGB1,HMGB2,HMOX1,HYAL2,IDO1,IGF1,IL1R2,IL1RL1,IL33,LDLR,LGALS9,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,THBS1,TIMP1,TLR4,CD200,CD28,CD300A,CD96,TNFAIP3,TRPV4,CEBPB,CIITA,CMKLR1,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DROSHA"]
["GO:BP","granulocyte migration","GO:0097530",{"v":17660.482811505,"d":"1.77E+04"},151,235,19,18117,"PIK3CG,C5AR1,FCER1G,SLIT2,CAMK1D,IL1R1,JAM3,RARRES2,THBS1,CCL4,CCL5,CD300A,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","regulation of protein serine/threonine kinase activity","GO:0071900",{"v":1861.8805984737,"d":"1.86E+03"},503,235,32,18117,"EGFR,ADAM17,AGER,APOE,PDCD4,PIK3CG,C5AR1,FGFR1,FPR1,GSTP1,HGF,SNCA,STK39,HYAL2,IGF1,IRAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CD300A,CD81,TNFAIP3,CSF1R,CXCL17,DDX3X"]
["GO:BP","negative regulation of cell population proliferation","GO:0008285",{"v":2129.61861705872,"d":"2.13E+03"},790,235,40,18117,"EIF2AK1,ENPP3,ALOX5,APOE,APP,APPL2,SERPINF1,NOTCH1,NUPR1,ATM,PDCD4,BCL6,GJA1,GSTP1,HAVCR2,PPARD,PPARG,SPN,STAT3,PTGS2,PTPN2,HMOX1,IDO1,IL2RA,IL33,JAK2,LGALS9,LYN,RBPJ,TGFB1,THBS1,TLR2,CD200,CD300A,CDH5,TNFAIP3,CEBPB,CSF1R,CTNNBIP1,DICER1"]
["GO:BP","muscle cell proliferation","GO:0033002",{"v":216.693395999509,"d":"2.17E+02"},244,235,23,18117,"EGFR,NOTCH1,PDCD4,GJA1,GSTP1,CALCRL,PPARD,PPARG,STAT3,PTAFR,PTGS2,HMOX1,IGF1,IL18,JAK2,MAPK14,RBPJ,TGM2,THBS1,CCL5,TNFAIP3,CTNNBIP1,CX3CL1"]
["GO:BP","positive regulation of leukocyte proliferation","GO:0070665",{"v":2827.9879572445,"d":"2.83E+03"},155,235,19,18117,"AGER,BCL6,HAVCR2,STAT5B,PRKCQ,HMGB1,IGF1,IL18,IL2RA,LGALS9,LYN,TLR4,CCL5,CCR2,CD28,CD6,CD81,CSF1,CSF1R"]
["GO:BP","positive regulation of programmed cell death","GO:0043068",{"v":4071.67385068705,"d":"4.07E+03"},621,235,35,18117,"ABR,NOTCH1,NOTCH2,NUPR1,ATM,PDCD4,BCL6,GRN,SLIT2,CAMK1D,SNCA,PPARG,PTGIS,PTGS2,PTPN2,HMGB1,HMOX1,HSPD1,HYAL2,IDO1,ITGAM,JAK2,LGALS9,LRRK2,LYN,TGFB1,TGM2,THBS1,CCL5,CDK19,TNFRSF1B,ZBP1,CTSC,CYLD,DDX3X"]
["GO:BP","regulation of interleukin-1 beta production","GO:0032651",{"v":5004.6498021588,"d":"5.00E+03"},102,235,16,18117,"AGER,AIM2,APP,P2RX7,GSTP1,SIRPA,STAT3,HMGB1,IGF1,JAK2,LGALS9,LPL,TLR4,TNFAIP3,CX3CL1,HK1"]
["GO:BP","cellular response to interleukin-1","GO:0071347",{"v":6994.92537162926,"d":"6.99E+03"},185,235,20,18117,"ADAMTS12,RORA,RPS6KA5,SIRPA,PSMA1,PTGIS,NFKB1,NFKBIA,HYAL2,ICAM1,IL1R1,IL1R2,IL1RAP,IRAK2,CCL4,CCL5,CD47,ZBP1,CEBPB,CX3CL1"]
["GO:BP","positive regulation of macrophage chemotaxis","GO:0010759",{"v":71777.0773269141,"d":"7.18E+04"},18,235,9,18117,"C5AR1,RARRES2,THBS1,CCL5,TRPV4,CMKLR1,CSF1,CSF1R,CXCL17"]
["GO:BP","regulation of cytokine production involved in inflammatory response","GO:1900015",{"v":7259.20173706734,"d":"7.26E+03"},72,235,14,18117,"ABCD1,ALOX5,APPL2,PDCD4,GBP5,SIRPA,PLD3,PPARA,STAT3,IL1R2,KPNA6,MAPK14,TLR4,CD6"]
["GO:BP","positive regulation of hydrolase activity","GO:0051345",{"v":7386.56960844032,"d":"7.39E+03"},783,235,39,18117,"EDNRA,EGFR,EPHA2,ABR,AGER,AIM2,APP,NR1H3,P2RX1,BCR,C5AR1,F3,FGFR1,FN1,GRN,SNCA,PPARG,STAT3,PRKCZ,PRKD1,PTAFR,HMGB1,HMGB2,HSPD1,ICAM1,JAK2,KIT,LGALS9,LRRK2,LYN,RASGRP1,CCL4,CCL5,CD200,CD300A,UACA,DHX9,CX3CL1,DDX3X"]
["GO:BP","cellular response to stress","GO:0033554",{"v":8237.17921027341,"d":"8.24E+03"},2111,235,68,18117,"MECOM,EGFR,EIF2AK1,EPHA2,ABCD1,AGER,ALOX5,MFHAS1,APP,RORA,NOTCH1,NR1H3,NUPR1,ATM,AXL,PARP4,PDCD4,BCL6,FANCA,FANCD2,GRN,GSTP1,HGF,SIRPA,SLAMF1,CASP4,PJA2,SNCA,PPARA,PPARD,PPARG,STK39,PRKD1,PSMA1,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,ICAM1,IL18RAP,IRAK2,JAK2,JAM3,LGALS9,LPCAT3,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,RELB,THBS1,TLR4,TNFAIP3,TNFRSF1B,TRPV4,ULK4,CEBPB,DHX9,CYBB,CYLD,DDX3X"]
["GO:BP","cytokine production involved in inflammatory response","GO:0002534",{"v":8801.73483828994,"d":"8.80E+03"},73,235,14,18117,"ABCD1,ALOX5,APPL2,PDCD4,GBP5,SIRPA,PLD3,PPARA,STAT3,IL1R2,KPNA6,MAPK14,TLR4,CD6"]
["GO:BP","positive regulation of macrophage migration","GO:1905523",{"v":8902.49909349571,"d":"8.90E+03"},26,235,10,18117,"C5AR1,RARRES2,THBS1,CCL5,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17"]
["GO:BP","regulation of MAP kinase activity","GO:0043405",{"v":9193.81103800129,"d":"9.19E+03"},316,235,25,18117,"EGFR,AGER,APOE,PDCD4,PIK3CG,C5AR1,FGFR1,FPR1,GSTP1,HGF,STK39,HYAL2,IGF1,IRAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,THBS1,TLR4,CD300A,CD81,CXCL17"]
["GO:BP","positive regulation of protein serine/threonine kinase activity","GO:0071902",{"v":9193.81103800129,"d":"9.19E+03"},316,235,25,18117,"EGFR,ADAM17,AGER,PIK3CG,C5AR1,FGFR1,FPR1,HGF,SNCA,STK39,IGF1,IRAK2,KIT,LRRK2,MAPK14,MAPKAPK2,RASGRP1,RICTOR,TGFB1,THBS1,TLR4,CD81,CSF1R,CXCL17,DDX3X"]
["GO:BP","cellular protein metabolic process","GO:0044267",{"v":9267.77144750719,"d":"9.27E+03"},5229,235,120,18117,"MECOM,EDNRB,EGFR,EIF2AK1,EPHA2,ABHD12,ABR,ACE,ADAM17,ADAMTS12,AGER,AIM2,MFHAS1,APOE,APP,SERPINB9,SERPINE1,SERPINF1,RPS19,RPS6KA5,NR1H3,NUPR1,P2RX1,ASH1L,ATM,AXL,PARP4,PDCD4,PIK3CG,BCL6,BCR,C5AR1,F3,FABP4,FGFR1,FN1,FPR1,GPRC5B,GRN,GSTP1,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,PJA2,SNCA,PPARG,SOCS3,STAP1,STAT3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL1R2,IL33,IRAK2,JAK2,KIT,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD28,CD300A,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,UACA,ULK4,VPS35,CIITA,CSF1,CSF1R,CTSC,CTSS,DHX9,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","positive regulation of apoptotic process","GO:0043065",{"v":9313.02938244847,"d":"9.31E+03"},604,235,34,18117,"ABR,NOTCH1,NOTCH2,NUPR1,ATM,PDCD4,BCL6,GRN,SLIT2,CAMK1D,SNCA,PPARG,PTGIS,PTGS2,PTPN2,HMGB1,HMOX1,HSPD1,HYAL2,IDO1,ITGAM,JAK2,LGALS9,LYN,TGFB1,TGM2,THBS1,CCL5,CDK19,TNFRSF1B,ZBP1,CTSC,CYLD,DDX3X"]
["GO:BP","granulocyte chemotaxis","GO:0071621",{"v":109496.381477938,"d":"1.09E+05"},126,235,17,18117,"PIK3CG,C5AR1,FCER1G,SLIT2,CAMK1D,JAM3,RARRES2,THBS1,CCL4,CCL5,TRPV4,CMKLR1,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["GO:BP","neurogenesis","GO:0022008",{"v":116039.783786895,"d":"1.16E+05"},1675,235,59,18117,"EDNRB,EGFR,EPHA2,AGER,AKNA,APOE,APP,APPL2,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,AXL,BCL6,C5AR1,FGFR1,FN1,GJA1,GPRC5B,GRN,GSTP1,HDAC9,HGF,C3,SLIT2,CAMK1D,PPARG,STAP1,STAT3,PRKCA,PRKCQ,PRKCZ,PRKD1,HMGB1,HMGB2,IL33,JAK2,JAM3,KIT,LDLR,LRRK2,LYN,RBPJ,TBC1D23,TGFB1,TLR2,TLR4,CCR2,TNFRSF1B,TRPV4,ULK4,CEBPB,CSF1,CSF1R,DICER1,CX3CL1,DAGLB,DUOXA1"]
["GO:BP","positive regulation of cell death","GO:0010942",{"v":129476.312483232,"d":"1.29E+05"},684,235,36,18117,"ABR,NOTCH1,NOTCH2,NUPR1,ATM,PDCD4,BCL6,GRN,SLIT2,CAMK1D,SNCA,PPARG,PTGIS,PTGS2,PTPN2,HMGB1,HMOX1,HSPD1,HYAL2,IDO1,ITGAM,JAK2,LGALS9,LRRK2,LYN,TGFB1,TGM2,THBS1,TLR4,CCL5,CDK19,TNFRSF1B,ZBP1,CTSC,CYLD,DDX3X"]
["GO:BP","regulation of macrophage chemotaxis","GO:0010758",{"v":136302.256613145,"d":"1.36E+05"},27,235,10,18117,"C5AR1,STAP1,RARRES2,THBS1,CCL5,TRPV4,CMKLR1,CSF1,CSF1R,CXCL17"]
["GO:BP","response to abiotic stimulus","GO:0009628",{"v":136302.256613145,"d":"1.36E+05"},1261,235,50,18117,"EDNRA,EGFR,ABHD12,ADAM17,AGER,METRNL,APP,APPL2,SERPINF1,RORA,NOTCH1,ATM,PDE2A,FANCD2,GJA1,PPARA,PPARD,PPARG,STK39,PSMA1,PTAFR,PTGIS,PTGS2,NFKB1,NFKBIA,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,ITGB6,KIT,LPL,LXN,LYN,MAPK14,MAPKAPK2,RBPJ,RELB,TGFB1,THBS1,TIMP1,TLR2,TLR4,TRPV4,CIITA,CSRP3,CTSS,CYBB,DDX3X"]
["GO:BP","dendritic cell differentiation","GO:0097028",{"v":138619.954990568,"d":"1.39E+05"},48,235,12,18117,"AGER,NOTCH2,AXL,CAMK4,HMGB1,ITGB6,LGALS9,LYN,RBPJ,RELB,TGFB1,CEBPB"]
["GO:BP","protein metabolic process","GO:0019538",{"v":141798.918350424,"d":"1.42E+05"},5808,235,128,18117,"MECOM,EDNRB,EGFR,EIF2AK1,EPHA2,ABHD12,ABR,ACE,ADAM17,ADAMTS12,AGER,AIM2,MFHAS1,APOE,APP,SERPINB9,SERPINE1,SERPINF1,RPS19,RPS6KA5,NR1H3,NUPR1,OLR1,P2RX1,ASH1L,ATM,AXL,PARP4,PDCD4,PIK3CG,BCL6,BCR,C5AR1,F3,F8,FABP4,FGFR1,FN1,FPR1,GJA1,GPRC5B,GRN,GSTP1,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,CASP4,PJA2,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL1R2,IL33,IRAK2,JAK2,KIT,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD28,CD300A,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TPSB2,UACA,ULK4,VPS35,CIITA,CSF1,CSF1R,CTSC,CTSS,DHX9,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","regulation of peptidyl-tyrosine phosphorylation","GO:0050730",{"v":1597.58884270331,"d":"1.60E+03"},269,235,23,18117,"EGFR,ACE,ADAM17,APP,GPRC5B,HGF,SOCS3,STAP1,STAT3,PRKCZ,PTPN2,HYAL2,ICAM1,IGF1,IL18,JAK2,KIT,LYN,RICTOR,CCL5,CD300A,CD81,CSF1R"]
["GO:BP","peptidyl-tyrosine phosphorylation","GO:0018108",{"v":175700.039090859,"d":"1.76E+05"},385,235,27,18117,"EGFR,EPHA2,ACE,ADAM17,APP,AXL,FGFR1,GPRC5B,HCK,HGF,SOCS3,STAP1,STAT3,PRKCZ,PTPN2,HYAL2,ICAM1,IGF1,IL18,JAK2,KIT,LYN,RICTOR,CCL5,CD300A,CD81,CSF1R"]
["GO:BP","ion homeostasis","GO:0050801",{"v":18762.6633797036,"d":"1.88E+04"},808,235,39,18117,"EDNRA,EDNRB,EGFR,EIF2AK1,ABCD1,APOE,APP,SCNN1B,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,GRN,SLC11A1,SNCA,STK39,PRKD1,PTGDR,PTGFR,HMGB1,HMOX1,HYAL2,JAK2,LRRK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","response to interferon-gamma","GO:0034341",{"v":19560.6547385574,"d":"1.96E+04"},196,235,20,18117,"NR1H3,GBP5,HCK,SIRPA,SLC11A1,SNCA,PPARG,SOCS3,PTAFR,PTPN2,ICAM1,JAK2,LGALS9,TLR2,TLR4,CCL4,CCL5,CD47,CIITA,CX3CL1"]
["GO:BP","divalent inorganic cation homeostasis","GO:0072507",{"v":19560.6547385574,"d":"1.96E+04"},516,235,31,18117,"EDNRA,EDNRB,EGFR,APOE,APP,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,SLC11A1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,JAK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","peptidyl-tyrosine modification","GO:0018212",{"v":208438.576626304,"d":"2.08E+05"},388,235,27,18117,"EGFR,EPHA2,ACE,ADAM17,APP,AXL,FGFR1,GPRC5B,HCK,HGF,SOCS3,STAP1,STAT3,PRKCZ,PTPN2,HYAL2,ICAM1,IGF1,IL18,JAK2,KIT,LYN,RICTOR,CCL5,CD300A,CD81,CSF1R"]
["GO:BP","T cell activation involved in immune response","GO:0002286",{"v":208438.576626304,"d":"2.08E+05"},112,235,16,18117,"RORA,BCL6,FCER1G,HAVCR2,SLC11A1,SPN,STAT3,PRKCZ,NFKBID,HMGB1,ICAM1,IL18,IL18R1,LGALS9,RELB,CD81"]
["GO:BP","regulation of smooth muscle cell proliferation","GO:0048660",{"v":215269.771908337,"d":"2.15E+05"},174,235,19,18117,"EGFR,PDCD4,GJA1,GSTP1,CALCRL,PPARD,PPARG,PTAFR,PTGS2,HMOX1,IGF1,IL18,JAK2,TGM2,THBS1,CCL5,TNFAIP3,CTNNBIP1,CX3CL1"]
["GO:BP","neutrophil activation involved in immune response","GO:0002283",{"v":220429.896755224,"d":"2.20E+05"},485,235,30,18117,"ALOX5,OLR1,P2RX1,C5AR1,FCER1G,FPR1,GRN,GSTP1,C3,SIRPA,SLC11A1,SNAP23,PRCP,PTAFR,NFKB1,HMGB1,ITGAM,MAPK14,TCIRG1,TLR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X,DNASE1"]
["GO:BP","enzyme linked receptor protein signaling pathway","GO:0007167",{"v":22835.1383017957,"d":"2.28E+04"},1103,235,46,18117,"EGFR,EPHA2,ADAM17,ADAMTS12,APPL2,RPS6KA5,NOTCH1,NOTCH2,AXL,PDCD4,BCR,F3,FGFR1,HCK,HGF,SNCA,PPARA,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTPN2,NDST1,IGF1,ITGB6,JAK2,KIT,LYN,MAPK14,MAPKAPK2,RARRES2,RBPJ,TCIRG1,TGFB1,THBS1,CDH5,CSF1,CSF1R,CSRP3,CYBB"]
["GO:BP","regulation of granulocyte chemotaxis","GO:0071622",{"v":22835.1383017957,"d":"2.28E+04"},50,235,12,18117,"C5AR1,SLIT2,CAMK1D,JAM3,RARRES2,THBS1,CCL5,TRPV4,CMKLR1,CSF1,CSF1R,CXCL17"]
["GO:BP","response to tumor necrosis factor","GO:0034612",{"v":243920.050193816,"d":"2.44E+05"},331,235,25,18117,"ADAM17,ADAMTS12,AIM2,RORA,SGMS1,FABP4,GSTP1,CASP4,PSMA1,PTGS2,PTPN2,NFKB1,NFKBIA,HYAL2,ICAM1,JAK2,MAPK14,THBS1,CCL4,CCL5,TNFAIP3,TNFRSF1B,DHX9,CX3CL1,CYLD"]
["GO:BP","smooth muscle cell proliferation","GO:0048659",{"v":260286.964882599,"d":"2.60E+05"},176,235,19,18117,"EGFR,PDCD4,GJA1,GSTP1,CALCRL,PPARD,PPARG,PTAFR,PTGS2,HMOX1,IGF1,IL18,JAK2,TGM2,THBS1,CCL5,TNFAIP3,CTNNBIP1,CX3CL1"]
["GO:BP","regulation of T cell proliferation","GO:0042129",{"v":260286.964882599,"d":"2.60E+05"},176,235,19,18117,"AGER,HAVCR2,SPN,STAT5B,PRKCQ,HMGB1,IDO1,IGF1,IL18,IL2RA,LGALS9,TGFB1,CCL5,CCR2,CD28,CD6,CD81,TNFRSF1B,CEBPB"]
["GO:BP","regulation of ion transport","GO:0043269",{"v":282537.941345975,"d":"2.83E+05"},1379,235,52,18117,"EDNRA,EGFR,ALOX5,APOE,APP,APPL2,SCN9A,NR1H3,P2RX1,P2RX7,PIK3CG,GJA1,C3,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STK39,PRKCA,PRKCZ,PRKD1,PTAFR,PTGS2,PXK,NFKB1,NFKBIA,HYAL2,ICAM1,IGF1,IL16,ITGAM,JAK2,LPCAT3,LRRK2,LYN,MAPK14,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD81,CEBPB,CTSS,DHX9,CX3CL1,CYBB"]
["GO:BP","metal ion homeostasis","GO:0055065",{"v":288960.478916938,"d":"2.89E+05"},667,235,35,18117,"EDNRA,EDNRB,EGFR,EIF2AK1,APOE,APP,SCNN1B,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,SLC11A1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,HMOX1,HYAL2,JAK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","alpha-beta T cell activation","GO:0046631",{"v":290524.208025194,"d":"2.91E+05"},155,235,18,18117,"AGER,RORA,BCL6,SPN,STAT3,PRKCQ,PRKCZ,NFKBID,HMGB1,IL18,IL18R1,LGALS9,RELB,TCIRG1,CCR2,CD28,CD300A,CD81"]
["GO:BP","cellular response to tumor necrosis factor","GO:0071356",{"v":30813.9973276661,"d":"3.08E+04"},306,235,24,18117,"ADAM17,ADAMTS12,AIM2,RORA,SGMS1,FABP4,GSTP1,CASP4,PSMA1,PTPN2,NFKB1,NFKBIA,HYAL2,ICAM1,JAK2,MAPK14,THBS1,CCL4,CCL5,TNFAIP3,TNFRSF1B,DHX9,CX3CL1,CYLD"]
["GO:BP","positive regulation of interleukin-1 production","GO:0032732",{"v":31694.6246916373,"d":"3.17E+04"},65,235,13,18117,"AGER,AIM2,APP,P2RX7,HAVCR2,STAT3,HMGB1,IL16,JAK2,LGALS9,LPL,TLR4,HK1"]
["GO:BP","cellular calcium ion homeostasis","GO:0006874",{"v":3270.65576399157,"d":"3.27E+03"},460,235,29,18117,"EDNRA,EDNRB,APOE,APP,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,JAK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","regulation of reactive oxygen species metabolic process","GO:2000377",{"v":36148.7253218289,"d":"3.61E+04"},203,235,20,18117,"EGFR,ABCD1,ALOX5,GSTP1,SIRPA,SNCA,PPARA,STAT3,PRCP,PTGIS,PTGS2,HSPD1,ICAM1,ITGAM,JAK2,MAPK14,THBS1,TLR4,CD47,DUOXA1"]
["GO:BP","cation homeostasis","GO:0055080",{"v":384855.136570359,"d":"3.85E+05"},750,235,37,18117,"EDNRA,EDNRB,EGFR,EIF2AK1,APOE,APP,SCNN1B,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,GRN,SLC11A1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,HMOX1,HYAL2,JAK2,LRRK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","cellular divalent inorganic cation homeostasis","GO:0072503",{"v":394974.346871093,"d":"3.95E+05"},497,235,30,18117,"EDNRA,EDNRB,APOE,APP,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,SLC11A1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,JAK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","regulation of biosynthetic process","GO:0009889",{"v":459048.695672203,"d":"4.59E+05"},4361,235,105,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ABCD1,AGER,AIM2,AKNA,ALOX5,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,BCL6,FABP4,FANCA,FANCD2,GJA1,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD47,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DUOXA1"]
["GO:BP","regulation of vesicle-mediated transport","GO:0060627",{"v":49839.7741110569,"d":"4.98E+04"},536,235,31,18117,"APOE,APPL2,SDC1,SERPINE1,NOTCH1,NR1H3,P2RX1,AXL,FCER1G,HCK,C3,SIRPA,SLC11A1,CAMK1D,SNCA,PPARG,STAP1,PRKD1,PTAFR,HMGB1,HMOX1,ITGAM,LGALS9,LRRK2,LYN,TGFB1,TLR2,CCR2,CD300A,CD47,UNC13D"]
["GO:BP","negative regulation of molecular function","GO:0044092",{"v":51436.0733884186,"d":"5.14E+04"},1219,235,48,18117,"EDNRB,ACE,AIM2,APOE,APP,SERPINB9,SERPINE1,SERPINF1,NOTCH1,NUPR1,PDCD4,FABP4,GSTP1,HAVCR2,HDAC9,HGF,C3,SLIT2,SNCA,PPARA,PPARG,SOCS3,STK39,PRKCZ,PTGIS,PTGS2,PTPN2,PXK,NFKB1,NFKBIA,HMOX1,HYAL2,IRAK2,JAK2,LRRK2,LXN,LYN,THBS1,TIMP1,CCR2,CD200,CD300A,TNFAIP3,CMKLR1,CNR2,CTNNBIP1,CYLD,DDX3X"]
["GO:BP","regulation of cytokine-mediated signaling pathway","GO:0001959",{"v":55868.8319022467,"d":"5.59E+04"},184,235,19,18117,"ADAM17,NR1H3,AXL,GSTP1,SLIT2,CASP4,PPARG,SOCS3,STAP1,PTPN2,IL1R1,IL1R2,IRAK2,JAK2,CCL5,TNFAIP3,ZBP1,CSF1,CYLD"]
["GO:BP","transmembrane receptor protein tyrosine kinase signaling pathway","GO:0007169",{"v":5603.09693789363,"d":"5.60E+03"},760,235,37,18117,"EGFR,EPHA2,ADAM17,ADAMTS12,RPS6KA5,AXL,BCR,F3,FGFR1,HCK,HGF,SNCA,SOCS3,STAP1,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PTPN2,NDST1,IGF1,JAK2,KIT,LYN,MAPK14,MAPKAPK2,RARRES2,RBPJ,TCIRG1,THBS1,CSF1,CSF1R,CSRP3,CYBB"]
["GO:BP","inorganic ion homeostasis","GO:0098771",{"v":58094.0211365909,"d":"5.81E+04"},761,235,37,18117,"EDNRA,EDNRB,EGFR,EIF2AK1,APOE,APP,SCNN1B,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,GRN,SLC11A1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,HMOX1,HYAL2,JAK2,LRRK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","calcium ion homeostasis","GO:0055074",{"v":60120.4973144814,"d":"6.01E+04"},472,235,29,18117,"EDNRA,EDNRB,APOE,APP,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,JAK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","stress-activated protein kinase signaling cascade","GO:0031098",{"v":60902.5283027677,"d":"6.09E+04"},288,235,23,18117,"MECOM,EGFR,AGER,MFHAS1,APP,PDCD4,GSTP1,HGF,SIRPA,SLAMF1,PJA2,NFKB1,HMGB1,IRAK2,LGALS9,LYN,MAPK14,MAPKAPK2,RASGRP1,TLR4,TRPV4,ULK4,CYLD"]
["GO:BP","establishment of localization","GO:0051234",{"v":61985.7303771771,"d":"6.20E+04"},5372,235,120,18117,"MCPH1,EDNRA,EDNRB,EGFR,EIF2AK1,ABCC1,ABCD1,ACE,AGER,ALOX5,APOE,APP,APPL2,SCN9A,SCNN1B,SDC1,SERPINE1,RPS19,NOTCH1,NR1H3,OLR1,P2RX1,P2RX7,ATM,AXL,PIK3CG,C5AR1,F8,FABP4,FCER1G,FN1,FPR1,GJA1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLC7A2,CALCRL,CAMK1D,PLA2G4A,SNAP23,SNCA,PPARA,PPARD,PPARG,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGS2,PXK,NFKB1,NFKBIA,HMGB1,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL16,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD163,CD200,CD300A,CD47,CD6,CD68,CD81,TNFAIP3,TNFRSF1B,TRPV4,UNC13D,VPS35,CEBPB,CTSC,CTSS,DHX9,CX3CL1,CYBB,CYSLTR1,DDX3X,DUOXA1,HK1"]
["GO:BP","positive regulation of macrophage activation","GO:0043032",{"v":62268.4524221106,"d":"6.23E+04"},31,235,10,18117,"HAVCR2,PLA2G4A,STAP1,HSPD1,IL1RL1,IL33,LRRK2,THBS1,TLR4,CTSC"]
["GO:BP","cellular response to peptide","GO:1901653",{"v":62856.3797169856,"d":"6.29E+04"},408,235,27,18117,"ABCC1,AGER,APP,APPL2,GJA1,GSTP1,HDAC9,CASP4,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PTPN2,NFKB1,ICAM1,IGF1,JAK2,LPL,LYN,RARRES2,TCIRG1,TGFB1,TLR4,CSRP3"]
["GO:BP","tissue remodeling","GO:0048771",{"v":663.87957873448,"d":"6.64E+02"},186,235,19,18117,"EGFR,ELF3,EPHA2,ACE,AGER,NOTCH2,P2RX7,AXL,GJA1,PRKCA,IL18,LIPA,RBPJ,TCIRG1,TGM2,TIMP1,CCR2,TNFAIP3,CSF1R"]
["GO:BP","positive regulation of mononuclear cell proliferation","GO:0032946",{"v":7089.95301577225,"d":"7.09E+03"},142,235,17,18117,"AGER,BCL6,HAVCR2,STAT5B,PRKCQ,HMGB1,IGF1,IL18,IL2RA,LGALS9,TLR4,CCL5,CCR2,CD28,CD6,CD81,CSF1"]
["GO:BP","positive regulation of epithelial cell proliferation","GO:0050679",{"v":84799.2538568305,"d":"8.48E+04"},213,235,20,18117,"EGFR,ADAM17,NOTCH1,NOTCH2,C5AR1,F3,FGFR1,GRN,STAT3,STAT5A,PRKCA,PRKD1,HMGB1,HMGB2,HMOX1,IGF1,RICTOR,TGFB1,TLR4,TNFAIP3"]
["GO:BP","CD4-positive, alpha-beta T cell activation","GO:0035710",{"v":8578.86425833191,"d":"8.58E+03"},104,235,15,18117,"AGER,RORA,BCL6,SPN,STAT3,PRKCQ,PRKCZ,NFKBID,HMGB1,IL18,IL18R1,LGALS9,RELB,TCIRG1,CD81"]
["GO:BP","regulation of neuron death","GO:1901214",{"v":92534.3284651993,"d":"9.25E+04"},323,235,24,18117,"APOE,SERPINF1,NUPR1,ATM,AXL,C5AR1,GRN,SNCA,PPARA,STAT3,HMOX1,HSPD1,ITGAM,JAK2,LRRK2,REL,TLR4,CCL5,CD200,TNFRSF1B,VPS35,CEBPB,CSF1,CX3CL1"]
["GO:BP","neutrophil degranulation","GO:0043312",{"v":97967.4832306734,"d":"9.80E+04"},482,235,29,18117,"ALOX5,OLR1,P2RX1,C5AR1,FCER1G,FPR1,GRN,GSTP1,C3,SIRPA,SLC11A1,SNAP23,PRCP,PTAFR,NFKB1,HMGB1,ITGAM,MAPK14,TCIRG1,TLR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X"]
["GO:BP","lymphocyte mediated immunity","GO:0002449",{"v":99342.6607115556,"d":"9.93E+04"},354,235,25,18117,"AGER,SERPINB9,BCL6,FCER1G,HAVCR2,C3,STAT5B,PRKCZ,HMGB1,HSPD1,ICAM1,IL18,IL18R1,IL18RAP,IL1R1,LGALS9,RASGRP1,TCIRG1,CCR2,CD28,CD81,CD96,TNFRSF1B,UNC13D,CTSC"]
["GO:BP","positive regulation of innate immune response","GO:0045089",{"v":1084442.65252724,"d":"1.08E+06"},216,235,20,18117,"AIM2,RPS19,RPS6KA5,FCER1G,GBP5,HAVCR2,HCK,STAT5B,PSMA1,NFKB1,HMGB1,HMGB2,IL18RAP,LYN,RASGRP1,RELB,TLR4,CCL5,ZBP1,DHX9"]
["GO:BP","toll-like receptor 4 signaling pathway","GO:0034142",{"v":1136533.17052711,"d":"1.14E+06"},44,235,11,18117,"MFHAS1,APPL2,NR1H3,PIK3AP1,NFKBIA,HMGB1,ITGAM,LY96,LYN,TLR4,TNFAIP3"]
["GO:BP","NIK/NF-kappaB signaling","GO:0038061",{"v":1372544.79060868,"d":"1.37E+06"},194,235,19,18117,"EGFR,AGER,APP,PDCD4,HAVCR2,PSMA1,NFKBIA,HMGB1,IL18,IL18R1,LGALS9,REL,RELB,TLR2,TLR4,UACA,DICER1,CYLD,DDX3X"]
["GO:BP","stress-activated MAPK cascade","GO:0051403",{"v":1375701.64861786,"d":"1.38E+06"},272,235,22,18117,"MECOM,EGFR,AGER,MFHAS1,APP,PDCD4,GSTP1,HGF,SIRPA,SLAMF1,PJA2,NFKB1,HMGB1,IRAK2,LGALS9,MAPK14,MAPKAPK2,RASGRP1,TLR4,TRPV4,ULK4,CYLD"]
["GO:BP","activation of protein kinase activity","GO:0032147",{"v":1526118.19496307,"d":"1.53E+06"},331,235,24,18117,"EGFR,C5AR1,FPR1,GPRC5B,HGF,SLC11A1,STK39,PRKCZ,HMGB1,IGF1,IL18,IRAK2,JAK2,KIT,LRRK2,MAPK14,MAPKAPK2,RICTOR,THBS1,TLR4,CCL5,CD300A,CD81,CXCL17"]
["GO:BP","regulation of proteolysis","GO:0030162",{"v":1752535.19441158,"d":"1.75E+06"},752,235,36,18117,"AGER,AIM2,APOE,APP,SERPINB9,SERPINE1,SERPINF1,NR1H3,NUPR1,P2RX1,F3,FN1,GRN,HGF,C3,SNCA,PPARG,STAT3,PTGS2,HMGB1,HSPD1,IL1R2,IL33,JAK2,LGALS9,LPCAT3,LRRK2,LXN,LYN,THBS1,TIMP1,TNFRSF1B,TNIP1,UACA,CTSC,DDX3X"]
["GO:BP","ameboidal-type cell migration","GO:0001667",{"v":1752535.19441158,"d":"1.75E+06"},494,235,29,18117,"EDNRB,EPHA2,ADAM17,APOE,APPL2,SERPINF1,NOTCH1,PIK3CG,FGFR1,FN1,GJA1,GRN,HDAC9,SLIT2,PPARD,PPARG,STAT5A,PRCP,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,HYAL2,KIT,TGFB1,THBS1,TIMP1,CDH5"]
["GO:BP","neuron death","GO:0070997",{"v":1892386.3460775,"d":"1.89E+06"},365,235,25,18117,"APOE,APP,SERPINF1,NUPR1,ATM,AXL,C5AR1,GRN,SNCA,PPARA,STAT3,HMOX1,HSPD1,ITGAM,JAK2,LRRK2,REL,TLR4,CCL5,CD200,TNFRSF1B,VPS35,CEBPB,CSF1,CX3CL1"]
["GO:BP","positive regulation of lymphocyte activation","GO:0051251",{"v":1892386.3460775,"d":"1.89E+06"},365,235,25,18117,"AGER,AXL,BCL6,HAVCR2,SIRPA,STAT5B,PRKCQ,PRKCZ,NFKBID,HMGB1,HSPD1,IGF1,IL18,IL2RA,LGALS9,LYN,RASGRP1,TGFB1,TLR4,CCL5,CCR2,CD28,CD47,CD6,CD81"]
["GO:BP","response to peptide hormone","GO:0043434",{"v":1910331.7790647,"d":"1.91E+06"},462,235,28,18117,"EDNRB,APPL2,GJA1,GSTP1,HDAC9,PPARA,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PTGS2,PTPN2,NFKB1,ICAM1,JAK2,LPL,LYN,RARRES2,TCIRG1,TGFB1,TIMP1,TLR2,TRPV4,CSRP3,CYBB"]
["GO:BP","negative regulation of leukocyte proliferation","GO:0070664",{"v":20332.1535812785,"d":"2.03E+04"},92,235,14,18117,"ENPP3,ATM,GSTP1,HAVCR2,SPN,IDO1,IL2RA,IL33,LGALS9,LYN,TGFB1,CD300A,TNFAIP3,CEBPB"]
["GO:BP","regulation of T cell differentiation","GO:0045580",{"v":2062675.91374468,"d":"2.06E+06"},152,235,17,18117,"BCL6,FANCA,FANCD2,CAMK4,STAT5B,PRKCZ,PTPN2,NFKBID,HMGB1,IL18,IL2RA,LGALS9,RASGRP1,TGFB1,CCR2,CD28,DROSHA"]
["GO:BP","cell killing","GO:0001906",{"v":209841.058144066,"d":"2.10E+05"},175,235,18,18117,"AGER,SERPINB9,RPS19,P2RX7,HAVCR2,C3,STAP1,STAT5B,ICAM1,IL18,IL18RAP,ITGAM,LGALS9,RASGRP1,UNC13D,CFH,CTSC,DNASE1"]
["GO:BP","regulation of interleukin-10 production","GO:0032653",{"v":209841.058144066,"d":"2.10E+05"},60,235,12,18117,"AGER,HGF,STAT3,PRKCZ,HMGB1,HSPD1,IDO1,LGALS9,TLR2,TLR4,CD28,CD47"]
["GO:BP","cellular response to interferon-gamma","GO:0071346",{"v":209841.058144066,"d":"2.10E+05"},175,235,18,18117,"NR1H3,GBP5,HCK,SIRPA,PPARG,SOCS3,PTAFR,PTPN2,ICAM1,JAK2,LGALS9,TLR2,TLR4,CCL4,CCL5,CD47,CIITA,CX3CL1"]
["GO:BP","toll-like receptor 2 signaling pathway","GO:0034134",{"v":235769.728824605,"d":"2.36E+05"},17,235,8,18117,"MFHAS1,PIK3AP1,PJA2,HMGB1,LYN,TLR1,TLR2,TNFAIP3"]
["GO:BP","cellular response to hormone stimulus","GO:0032870",{"v":236261.043616991,"d":"2.36E+05"},645,235,33,18117,"EGFR,APPL2,SCNN1B,SERPINB9,SERPINF1,NOTCH1,GJA1,GSTP1,HDAC9,SLIT2,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRCP,PRKCQ,PRKCZ,PTGFR,PTPN2,NFKB1,ICAM1,JAK2,KIT,LPL,LYN,RARRES2,TCIRG1,TGFB1,CSRP3,CTSS"]
["GO:BP","cellular chemical homeostasis","GO:0055082",{"v":237041.863782994,"d":"2.37E+05"},841,235,38,18117,"EDNRA,EDNRB,AGER,APOE,APP,SERPINF1,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,GRN,SLC11A1,SNCA,PPARD,PRKD1,PTGDR,PTGFR,HMGB1,HMOX1,ICAM1,JAK2,LRRK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1,HK1"]
["GO:BP","regulation of JNK cascade","GO:0046328",{"v":26890.9467575823,"d":"2.69E+04"},133,235,16,18117,"MECOM,EGFR,AGER,MFHAS1,APP,PDCD4,GSTP1,SIRPA,SLAMF1,PJA2,HMGB1,RASGRP1,TLR4,TRPV4,ULK4,CYLD"]
["GO:BP","cytokine production involved in immune response","GO:0002367",{"v":268922.270535188,"d":"2.69E+05"},94,235,14,18117,"BCL6,GPRC5B,PRKCZ,HMOX1,IL18,IL18R1,IL1R1,KIT,TLR4,CCR2,CD81,CD96,TNFRSF1B,HK1"]
["GO:BP","regulation of NIK/NF-kappaB signaling","GO:1901222",{"v":276660.325798203,"d":"2.77E+05"},113,235,15,18117,"EGFR,AGER,APP,PDCD4,HAVCR2,NFKBIA,HMGB1,IL18,IL18R1,LGALS9,TLR2,TLR4,UACA,CYLD,DDX3X"]
["GO:BP","transport","GO:0006810",{"v":3029763.75857839,"d":"3.03E+06"},5224,235,116,18117,"EDNRA,EDNRB,EGFR,EIF2AK1,ABCC1,ABCD1,ACE,AGER,ALOX5,APOE,APP,APPL2,SCN9A,SCNN1B,SDC1,SERPINE1,RPS19,NOTCH1,NR1H3,OLR1,P2RX1,P2RX7,AXL,PIK3CG,C5AR1,F8,FABP4,FCER1G,FN1,FPR1,GJA1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLC7A2,CALCRL,CAMK1D,PLA2G4A,SNAP23,SNCA,PPARA,PPARD,PPARG,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGS2,PXK,NFKB1,NFKBIA,HMGB1,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL16,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL4,CCL5,CCR2,CD163,CD200,CD300A,CD47,CD6,CD68,CD81,TNFRSF1B,TRPV4,UNC13D,VPS35,CEBPB,CTSC,CTSS,DHX9,CX3CL1,CYBB,CYSLTR1,DDX3X,DUOXA1"]
["GO:BP","interleukin-10 production","GO:0032613",{"v":3087176.26118167,"d":"3.09E+06"},62,235,12,18117,"AGER,HGF,STAT3,PRKCZ,HMGB1,HSPD1,IDO1,LGALS9,TLR2,TLR4,CD28,CD47"]
["GO:BP","mast cell activation","GO:0045576",{"v":3087176.26118167,"d":"3.09E+06"},62,235,12,18117,"ENPP3,PIK3CG,SNAP23,PTGDR,HMOX1,KIT,LGALS9,LYN,RASGRP1,CD300A,UNC13D,CNR2"]
["GO:BP","regulation of lymphocyte differentiation","GO:0045619",{"v":329679.461285669,"d":"3.30E+05"},180,235,18,18117,"AXL,BCL6,FANCA,FANCD2,CAMK4,STAT5B,PRKCZ,PTPN2,NFKBID,HMGB1,IL18,IL2RA,LGALS9,RASGRP1,TGFB1,CCR2,CD28,DROSHA"]
["GO:BP","mast cell activation involved in immune response","GO:0002279",{"v":3828521.83271122,"d":"3.83E+06"},49,235,11,18117,"ENPP3,PIK3CG,SNAP23,PTGDR,HMOX1,KIT,LGALS9,LYN,RASGRP1,CD300A,UNC13D"]
["GO:BP","mast cell mediated immunity","GO:0002448",{"v":3828521.83271122,"d":"3.83E+06"},49,235,11,18117,"SERPINB9,PIK3CG,SNAP23,PTGDR,HMOX1,KIT,LGALS9,LYN,RASGRP1,CD300A,UNC13D"]
["GO:BP","regulation of toll-like receptor signaling pathway","GO:0034121",{"v":3828521.83271122,"d":"3.83E+06"},79,235,13,18117,"MFHAS1,APPL2,NR1H3,PJA2,HMGB1,LY96,LYN,TLR1,TLR2,TLR4,CD300A,TNFAIP3,DDX3X"]
["GO:BP","positive regulation of proteolysis","GO:0045862",{"v":384397.820359901,"d":"3.84E+05"},378,235,25,18117,"AGER,AIM2,APOE,APP,NUPR1,P2RX1,F3,FN1,GRN,SNCA,PPARG,STAT3,HMGB1,HSPD1,IL33,JAK2,LGALS9,LPCAT3,LRRK2,LYN,TNFRSF1B,TNIP1,UACA,CTSC,DDX3X"]
["GO:BP","primary metabolic process","GO:0044238",{"v":434968.49203967,"d":"4.35E+05"},10584,235,185,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCD1,ABHD12,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AK7,AKNA,ALDH2,ALOX5,ALOX5AP,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FGFR1,FN1,FPR1,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1R2,IL1RAP,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD200,CD28,CD300A,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TPSB2,TRPV4,UACA,ULK4,VPS35,CEBPB,CERS6,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DAGLB,DDX3X,DNASE1,DROSHA,HK1"]
["GO:BP","regulation of phagocytosis","GO:0050764",{"v":468517.871801471,"d":"4.69E+05"},98,235,14,18117,"APPL2,FCER1G,HCK,C3,SIRPA,SLC11A1,CAMK1D,PPARG,STAP1,HMGB1,TGFB1,TLR2,CD300A,CD47"]
["GO:BP","regulation of cellular biosynthetic process","GO:0031326",{"v":478492.671891867,"d":"4.78E+05"},4273,235,101,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ABCD1,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,BCL6,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LDLR,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD47,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DUOXA1"]
["GO:BP","cellular metal ion homeostasis","GO:0006875",{"v":582243.217398566,"d":"5.82E+05"},593,235,31,18117,"EDNRA,EDNRB,APOE,APP,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,SLC11A1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,HMOX1,JAK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","regulation of RNA biosynthetic process","GO:2001141",{"v":597449.9464212,"d":"5.97E+05"},3540,235,89,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,BCL6,FABP4,FANCA,FANCD2,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","cellular response to macrophage colony-stimulating factor stimulus","GO:0036006",{"v":608916.667246791,"d":"6.09E+05"},12,235,7,18117,"PDE2A,STAP1,PTPN2,TLR2,TLR4,CSF1,CSF1R"]
["GO:BP","response to macrophage colony-stimulating factor","GO:0036005",{"v":608916.667246791,"d":"6.09E+05"},12,235,7,18117,"PDE2A,STAP1,PTPN2,TLR2,TLR4,CSF1,CSF1R"]
["GO:BP","phagocytosis","GO:0006909",{"v":625368.555724965,"d":"6.25E+05"},387,235,25,18117,"EIF2AK1,APPL2,NR1H3,AXL,FCER1G,HCK,C3,SIRPA,SLAMF1,SLC11A1,CAMK1D,PPARG,STAP1,HMGB1,ITGAM,LDLR,LYN,TGFB1,TGM2,THBS1,TLR2,TLR4,CD300A,CD47,UNC13D"]
["GO:BP","positive regulation of lymphocyte proliferation","GO:0050671",{"v":631362.953944896,"d":"6.31E+05"},141,235,16,18117,"AGER,BCL6,HAVCR2,STAT5B,PRKCQ,HMGB1,IGF1,IL18,IL2RA,LGALS9,TLR4,CCL5,CCR2,CD28,CD6,CD81"]
["GO:BP","negative regulation of neuron death","GO:1901215",{"v":649997.007515889,"d":"6.50E+05"},213,235,19,18117,"APOE,SERPINF1,AXL,C5AR1,GRN,SNCA,PPARA,STAT3,HMOX1,HSPD1,JAK2,LRRK2,REL,CD200,TNFRSF1B,VPS35,CEBPB,CSF1,CX3CL1"]
["GO:BP","cellular cation homeostasis","GO:0030003",{"v":688756.179112742,"d":"6.89E+05"},673,235,33,18117,"EDNRA,EDNRB,APOE,APP,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,GRN,SLC11A1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,HMOX1,JAK2,LRRK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","regulation of T-helper 1 type immune response","GO:0002825",{"v":706573.94110736,"d":"7.07E+05"},28,235,9,18117,"HAVCR2,SLC11A1,PLA2G4A,IL18,IL18R1,IL1R1,IL1RL1,IL33,CCR2"]
["GO:BP","aging","GO:0007568",{"v":80614.1550630626,"d":"8.06E+04"},329,235,23,18117,"EDNRB,AGER,APP,SERPINE1,SERPINF1,ATM,PDCD4,BCL6,GPX4,SNCA,STAT3,PTGS2,HYAL2,ICAM1,LRRK2,MAPK14,TGFB1,TIMP1,CD68,TNFRSF1B,CIITA,CTSC,CX3CL1"]
["GO:BP","cellular macromolecule metabolic process","GO:0044260",{"v":867420.117557512,"d":"8.67E+05"},8390,235,158,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,EPHA2,ABHD12,ABR,ACE,ADAM17,ADAMTS12,AGER,AIM2,AKNA,MFHAS1,APOE,APP,AOAH,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PIK3CG,BCL6,BCR,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,GJA1,GPRC5B,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,PJA2,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1R2,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD200,CD28,CD300A,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,VPS35,CEBPB,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,DNASE1,DROSHA"]
["GO:BP","positive regulation of NIK/NF-kappaB signaling","GO:1901224",{"v":927601.11421018,"d":"9.28E+05"},68,235,12,18117,"EGFR,AGER,APP,PDCD4,HAVCR2,HMGB1,IL18,IL18R1,LGALS9,TLR2,TLR4,DDX3X"]
["GO:BP","regulation of cytokine production involved in immune response","GO:0002718",{"v":961917.562835887,"d":"9.62E+05"},85,235,13,18117,"BCL6,GPRC5B,PRKCZ,HMOX1,IL18,IL18R1,IL1R1,TLR4,CCR2,CD81,CD96,TNFRSF1B,HK1"]
["GO:BP","regulation of stress-activated protein kinase signaling cascade","GO:0070302",{"v":10091068.2013316,"d":"1.01E+07"},193,235,18,18117,"MECOM,EGFR,AGER,MFHAS1,APP,PDCD4,GSTP1,HGF,SIRPA,SLAMF1,PJA2,HMGB1,LYN,RASGRP1,TLR4,TRPV4,ULK4,CYLD"]
["GO:BP","positive regulation of T cell proliferation","GO:0042102",{"v":10274792.872151,"d":"1.03E+07"},104,235,14,18117,"AGER,HAVCR2,STAT5B,PRKCQ,HMGB1,IGF1,IL18,IL2RA,LGALS9,CCL5,CCR2,CD28,CD6,CD81"]
["GO:BP","cellular response to chemical stress","GO:0062197",{"v":10613552.7221521,"d":"1.06E+07"},365,235,24,18117,"EGFR,ABCD1,ALOX5,ATM,AXL,FANCD2,GSTP1,HGF,SIRPA,SNCA,PPARG,STK39,PRKD1,PTGS2,HMOX1,IL18RAP,JAK2,LRRK2,RELB,TLR4,TNFAIP3,TRPV4,CYBB,DDX3X"]
["GO:BP","regulation of myeloid leukocyte mediated immunity","GO:0002886",{"v":11321117.2545463,"d":"1.13E+07"},54,235,11,18117,"C3,STAP1,PTAFR,HMOX1,ITGAM,LGALS9,LYN,CCR2,CD300A,UNC13D,DNASE1"]
["GO:BP","cellular ion homeostasis","GO:0006873",{"v":1154389.87213394,"d":"1.15E+06"},687,235,33,18117,"EDNRA,EDNRB,APOE,APP,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,GRN,SLC11A1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,HMOX1,JAK2,LRRK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYSLTR1"]
["GO:BP","nitrogen compound metabolic process","GO:0006807",{"v":13196253.7573163,"d":"1.32E+07"},10078,235,178,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AK7,AKNA,MFHAS1,APOE,APP,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FGFR1,FN1,FPR1,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1R2,IL1RAP,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD200,CD28,CD300A,CD47,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TPSB2,TRPV4,UACA,ULK4,VPS35,CEBPB,CERS6,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYLD,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","regulation of transcription, DNA-templated","GO:0006355",{"v":13393728.1845783,"d":"1.34E+07"},3534,235,88,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,BCL6,FABP4,FANCA,FANCD2,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","regulation of nucleic acid-templated transcription","GO:1903506",{"v":13569982.2028649,"d":"1.36E+07"},3535,235,88,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,BCL6,FABP4,FANCA,FANCD2,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","myeloid dendritic cell activation","GO:0001773",{"v":13865437.4333263,"d":"1.39E+07"},30,235,9,18117,"NOTCH2,HAVCR2,SLAMF1,CAMK4,HMGB1,ITGB6,RBPJ,RELB,TGFB1"]
["GO:BP","gliogenesis","GO:0042063",{"v":13865437.4333263,"d":"1.39E+07"},308,235,22,18117,"EGFR,AGER,APP,NOTCH1,C5AR1,GRN,GSTP1,PPARG,STAP1,STAT3,IL33,LDLR,LYN,TGFB1,TLR2,TLR4,CCR2,TNFRSF1B,CSF1,CSF1R,DICER1,CX3CL1"]
["GO:BP","leukocyte mediated cytotoxicity","GO:0001909",{"v":1488261.48664116,"d":"1.49E+06"},107,235,14,18117,"AGER,SERPINB9,HAVCR2,STAP1,STAT5B,ICAM1,IL18,IL18RAP,ITGAM,LGALS9,RASGRP1,UNC13D,CTSC,DNASE1"]
["GO:BP","temperature homeostasis","GO:0001659",{"v":1622595.24689069,"d":"1.62E+06"},174,235,17,18117,"EDNRB,ADAM17,APPL2,NOTCH1,NR1H3,FABP4,GJA1,STAT3,PTGS2,IL18,IL18R1,JAK2,RBPJ,TLR4,CCR2,CEBPB,CMKLR1"]
["GO:BP","positive regulation of interleukin-1 beta production","GO:0032731",{"v":16872768.3247275,"d":"1.69E+07"},56,235,11,18117,"AGER,AIM2,APP,P2RX7,STAT3,HMGB1,JAK2,LGALS9,LPL,TLR4,HK1"]
["GO:BP","myeloid cell homeostasis","GO:0002262",{"v":17078648.0905043,"d":"1.71E+07"},151,235,16,18117,"ADAM17,MFHAS1,RPS19,AXL,BCL6,STAT3,STAT5B,PTPN2,HMGB1,HMGB2,HMOX1,JAK2,JAM3,KIT,LYN,MAPK14"]
["GO:BP","regulation of type I interferon production","GO:0032479",{"v":19447786.1020187,"d":"1.94E+07"},130,235,15,18117,"HAVCR2,SIRPA,NFKB1,HMGB1,HMGB2,HSPD1,REL,RELB,TLR2,TLR4,TNFAIP3,ZBP1,DHX9,CYLD,DDX3X"]
["GO:BP","type I interferon production","GO:0032606",{"v":21664753.7974623,"d":"2.17E+07"},131,235,15,18117,"HAVCR2,SIRPA,NFKB1,HMGB1,HMGB2,HSPD1,REL,RELB,TLR2,TLR4,TNFAIP3,ZBP1,DHX9,CYLD,DDX3X"]
["GO:BP","generation of neurons","GO:0048699",{"v":21829826.1718667,"d":"2.18E+07"},1559,235,52,18117,"EDNRB,EGFR,EPHA2,AGER,AKNA,APOE,APP,APPL2,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,AXL,BCL6,FGFR1,FN1,GJA1,GPRC5B,GRN,HDAC9,HGF,C3,SLIT2,CAMK1D,PPARG,STAT3,PRKCA,PRKCQ,PRKCZ,PRKD1,HMGB1,HMGB2,JAK2,JAM3,KIT,LDLR,LRRK2,LYN,RBPJ,TBC1D23,TGFB1,TLR2,TNFRSF1B,TRPV4,ULK4,CEBPB,CSF1R,DICER1,CX3CL1,DAGLB,DUOXA1"]
["GO:BP","nucleobase-containing compound biosynthetic process","GO:0034654",{"v":2361879.29851399,"d":"2.36E+06"},4199,235,98,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,ENPP3,ABCD1,AGER,AIM2,AK7,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","regulation of RNA metabolic process","GO:0051252",{"v":2411512.16233778,"d":"2.41E+06"},3822,235,92,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,BCL6,FABP4,FANCA,FANCD2,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DROSHA"]
["GO:BP","regulation of reactive oxygen species biosynthetic process","GO:1903426",{"v":2411512.16233778,"d":"2.41E+06"},111,235,14,18117,"ABCD1,ALOX5,SIRPA,SNCA,PPARA,STAT3,PTGIS,PTGS2,HSPD1,ICAM1,JAK2,TLR4,CD47,DUOXA1"]
["GO:BP","heterocycle biosynthetic process","GO:0018130",{"v":25486369.5988245,"d":"2.55E+07"},4269,235,99,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,ENPP3,ABCD1,AGER,AIM2,AK7,AKNA,ALOX5,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","regulation of phosphatidylinositol 3-kinase signaling","GO:0014066",{"v":26576021.5949115,"d":"2.66E+07"},133,235,15,18117,"EGFR,PIK3AP1,PIK3CG,FGFR1,FN1,HGF,PPARD,IGF1,IL18,JAK2,KIT,LYN,RASGRP1,CCL5,CD28"]
["GO:BP","regulation of cellular component organization","GO:0051128",{"v":26854224.2948708,"d":"2.69E+07"},2412,235,68,18117,"MCPH1,EGFR,EPHA2,ACE,ADAM17,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ATM,AXL,PDE2A,BCL6,FN1,GBP5,GJA1,GRN,HCK,HGF,C3,SLIT2,CAMK1D,SNCA,PPARA,PPARD,PPARG,STAP1,PRKCQ,PRKCZ,PRKD1,HMGB1,HYAL2,ICAM1,IGF1,IL1RAP,JAM3,KIT,LDLR,LRFN5,LRRK2,LYN,MAPK14,RICTOR,TGFB1,THBS1,TLR2,TLR4,CD28,CD300A,CD47,CDH5,TNFRSF1B,TRPV4,ULK4,VPS35,CSF1R,CTNNBIP1,CX3CL1,CYLD,DDX3X"]
["GO:BP","T cell differentiation involved in immune response","GO:0002292",{"v":29006401.5052921,"d":"2.90E+07"},75,235,12,18117,"RORA,BCL6,FCER1G,SPN,STAT3,PRKCZ,NFKBID,HMGB1,IL18,IL18R1,LGALS9,RELB"]
["GO:BP","establishment of localization in cell","GO:0051649",{"v":29006401.5052921,"d":"2.90E+07"},2813,235,75,18117,"MCPH1,ABCD1,ALOX5,APOE,APP,APPL2,SERPINE1,RPS19,OLR1,P2RX1,P2RX7,ATM,PIK3CG,C5AR1,F8,FCER1G,FN1,FPR1,GJA1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,SNAP23,SNCA,PPARD,STAT3,PRCP,PRKCZ,PRKD1,PTAFR,PTGDR,PTGS2,NFKB1,NFKBIA,HMGB1,HMOX1,HSPD1,HYAL2,IGF1,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,TBC1D23,TCIRG1,TGFB1,THBS1,TIMP1,TLR2,CCR2,CD300A,CD47,CD68,CD81,TNFRSF1B,TRPV4,UNC13D,VPS35,CTSC,CTSS,DHX9,CX3CL1,CYBB,DDX3X"]
["GO:BP","regulation of cell killing","GO:0031341",{"v":2905957.75496517,"d":"2.91E+06"},93,235,13,18117,"AGER,SERPINB9,P2RX7,HAVCR2,STAP1,STAT5B,ICAM1,IL18RAP,ITGAM,LGALS9,RASGRP1,CFH,DNASE1"]
["GO:BP","positive regulation of phosphatidylinositol 3-kinase signaling","GO:0014068",{"v":2905957.75496517,"d":"2.91E+06"},93,235,13,18117,"PIK3AP1,PIK3CG,FGFR1,FN1,HGF,PPARD,IGF1,IL18,JAK2,KIT,LYN,CCL5,CD28"]
["GO:BP","positive regulation of hemopoiesis","GO:1903708",{"v":29744158.5211686,"d":"2.97E+07"},157,235,16,18117,"AGER,NOTCH2,AXL,BCL6,STAT5B,PRKCA,PRKCZ,NFKBID,HMGB1,IL18,IL2RA,LGALS9,RASGRP1,TGFB1,CSF1,CTNNBIP1"]
["GO:BP","positive regulation of leukocyte differentiation","GO:1902107",{"v":29744158.5211686,"d":"2.97E+07"},157,235,16,18117,"AGER,NOTCH2,AXL,BCL6,STAT5B,PRKCA,PRKCZ,NFKBID,HMGB1,IL18,IL2RA,LGALS9,RASGRP1,TGFB1,CSF1,CTNNBIP1"]
["GO:BP","positive regulation of MAP kinase activity","GO:0043406",{"v":3040709.37055786,"d":"3.04E+06"},234,235,19,18117,"EGFR,AGER,PIK3CG,C5AR1,FGFR1,FPR1,HGF,STK39,IGF1,IRAK2,KIT,LRRK2,MAPK14,MAPKAPK2,RASGRP1,THBS1,TLR4,CD81,CXCL17"]
["GO:BP","reactive oxygen species biosynthetic process","GO:1903409",{"v":32276218.3436051,"d":"3.23E+07"},135,235,15,18117,"ABCD1,ALOX5,RORA,SIRPA,SNCA,PPARA,STAT3,PTGIS,PTGS2,HSPD1,ICAM1,JAK2,TLR4,CD47,DUOXA1"]
["GO:BP","cellular metabolic process","GO:0044237",{"v":33605468.8474524,"d":"3.36E+07"},10871,235,186,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AK7,AKNA,ALDH2,ALOX5,ALOX5AP,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CALCRL,CAMK1D,CAMK4,PJA2,PLA2G4A,PLA2G7,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1R2,IL1RAP,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TCIRG1,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD200,CD28,CD300A,CD47,CD81,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,VPS35,CEBPB,CERS6,CIITA,CMKLR1,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CYBB,CYLD,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","regulation of macromolecule biosynthetic process","GO:0010556",{"v":34974930.0460369,"d":"3.50E+07"},4102,235,96,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,BCL6,FABP4,FANCA,FANCD2,GJA1,GSTP1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,LRRK2,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","positive regulation of transcription by RNA polymerase II","GO:0045944",{"v":36068690.7651256,"d":"3.61E+07"},1197,235,44,18117,"MECOM,EGFR,ELF3,AKNA,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,ASH1L,ATM,HGF,SLC11A1,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKD1,NFKB1,NFKBIA,HMGB1,HMGB2,HYAL2,IGF1,IL18,IL33,KPNA6,MAPK14,RBPJ,REL,TGFB1,TLR2,TLR4,CD28,CD81,TNIP1,CEBPB,CIITA,CSRP3,DHX9,CX3CL1,DDX3X"]
["GO:BP","positive regulation of cytosolic calcium ion concentration","GO:0007204",{"v":3668187.63946652,"d":"3.67E+06"},325,235,22,18117,"EDNRA,EDNRB,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,JAK2,LYN,TGFB1,TGM2,CCR2,TRPV4,CMKLR1,CX3CL1,CYSLTR1"]
["GO:BP","RNA biosynthetic process","GO:0032774",{"v":3787315.13613654,"d":"3.79E+06"},3731,235,90,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,BCL6,C5AR1,FABP4,FANCA,FANCD2,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","regulation of angiogenesis","GO:0045765",{"v":3953396.7831515,"d":"3.95E+06"},358,235,23,18117,"EPHA2,ALOX5,SERPINE1,SERPINF1,C5AR1,F3,GRN,HGF,C3,PPARG,STAB1,STAT3,PRKCA,PRKD1,PTGIS,HMGB1,HMOX1,THBS1,CCR2,CDH5,TNFAIP3,CX3CL1,CYBB"]
["GO:BP","positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains","GO:0002824",{"v":4266175.0204382,"d":"4.27E+06"},96,235,13,18117,"C3,SLC11A1,PLA2G4A,PRKCQ,PRKCZ,NFKBID,HSPD1,IL18,IL18R1,IL1R1,CCR2,CD28,CD81"]
["GO:BP","positive regulation of biosynthetic process","GO:0009891",{"v":4303471.94079688,"d":"4.30E+06"},2004,235,60,18117,"MECOM,EGFR,ELF3,ABCD1,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,ASH1L,ATM,HGF,SLC11A1,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKCQ,PRKD1,PTAFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HYAL2,ICAM1,IGF1,IL18,IL33,JAK2,KPNA6,LDLR,LRRK2,MAPK14,RBPJ,REL,TGFB1,THBS1,TLR2,TLR4,CCL5,CD28,CD81,TNIP1,CEBPB,CIITA,CSRP3,DHX9,CX3CL1,DDX3X,DUOXA1"]
["GO:BP","blood vessel endothelial cell migration","GO:0043534",{"v":4366560.92029771,"d":"4.37E+06"},186,235,17,18117,"EPHA2,ADAM17,APOE,NOTCH1,FGFR1,HDAC9,SLIT2,PPARG,STAT5A,PRCP,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,THBS1,CDH5"]
["GO:BP","regulation of cytosolic calcium ion concentration","GO:0051480",{"v":4373935.22104057,"d":"4.37E+06"},360,235,23,18117,"EDNRA,EDNRB,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,SNCA,PRKD1,PTGDR,PTGFR,HMGB1,JAK2,LYN,TGFB1,TGM2,CCR2,TRPV4,CMKLR1,CX3CL1,CYSLTR1"]
["GO:BP","regulation of secretion","GO:0051046",{"v":449223.067108251,"d":"4.49E+05"},647,235,31,18117,"EDNRB,EGFR,ALOX5,APOE,SDC1,NOTCH1,NR1H3,P2RX1,GJA1,PLA2G4A,SNCA,PPARD,STK39,PRKCA,PTAFR,HMOX1,IGF1,ITGAM,JAK2,LGALS9,LRRK2,LYN,TCIRG1,TLR2,TLR4,CCL5,CCR2,CD200,CD300A,TNFRSF1B,UNC13D"]
["GO:BP","regulation of cellular response to macrophage colony-stimulating factor stimulus","GO:1903972",{"v":45078318.8285244,"d":"4.51E+07"},5,235,5,18117,"STAP1,PTPN2,TLR2,TLR4,CSF1"]
["GO:BP","regulation of response to macrophage colony-stimulating factor","GO:1903969",{"v":45078318.8285244,"d":"4.51E+07"},5,235,5,18117,"STAP1,PTPN2,TLR2,TLR4,CSF1"]
["GO:BP","cellular homeostasis","GO:0019725",{"v":466011.454631198,"d":"4.66E+05"},981,235,39,18117,"EDNRA,EDNRB,AGER,APOE,APP,SERPINF1,P2RX1,P2RX7,PIK3CG,C5AR1,FPR1,FPR3,GJA1,GRN,SLC11A1,SNCA,PPARD,PRKD1,PTGDR,PTGFR,HMGB1,HMOX1,ICAM1,JAK2,LRRK2,LYN,TCIRG1,TGFB1,TGM2,CCL5,CCR2,CDH5,TRPV4,CMKLR1,CSRP3,CX3CL1,CYBB,CYSLTR1,HK1"]
["GO:BP","regulation of anion transport","GO:0044070",{"v":4929887.92233368,"d":"4.93E+06"},896,235,37,18117,"EDNRA,EGFR,ALOX5,APOE,APPL2,NR1H3,GJA1,C3,PLA2G4A,SNCA,PPARA,PPARD,PPARG,PRKCA,PRKCZ,PRKD1,PTAFR,PTGS2,NFKB1,NFKBIA,HYAL2,IGF1,ITGAM,JAK2,LPCAT3,LRRK2,MAPK14,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD81,CEBPB,DHX9"]
["GO:BP","regulation of vasculature development","GO:1901342",{"v":5364864.57657018,"d":"5.36E+06"},364,235,23,18117,"EPHA2,ALOX5,SERPINE1,SERPINF1,C5AR1,F3,GRN,HGF,C3,PPARG,STAB1,STAT3,PRKCA,PRKD1,PTGIS,HMGB1,HMOX1,THBS1,CCR2,CDH5,TNFAIP3,CX3CL1,CYBB"]
["GO:BP","response to oxidative stress","GO:0006979",{"v":5428853.70837111,"d":"5.43E+06"},466,235,26,18117,"EGFR,ABCD1,ALOX5,APOE,APP,SDC1,ATRN,AXL,FANCD2,GPX4,GSTP1,HGF,SIRPA,SNCA,PRKD1,PTGS1,PTGS2,HMOX1,HSPD1,HYAL2,IL18RAP,JAK2,LRRK2,TLR4,TNFAIP3,CYBB"]
["GO:BP","production of molecular mediator of immune response","GO:0002440",{"v":5503499.24406887,"d":"5.50E+06"},189,235,17,18117,"BCL6,GPRC5B,PRKCZ,HMOX1,HSPD1,IL18,IL18R1,IL1R1,IL33,KIT,TLR4,CCR2,CD28,CD81,CD96,TNFRSF1B,HK1"]
["GO:BP","positive regulation of interleukin-4 production","GO:0032753",{"v":5534250.44768955,"d":"5.53E+06"},24,235,8,18117,"FCER1G,HAVCR2,PRKCQ,PRKCZ,IL33,LGALS9,CD28,CEBPB"]
["GO:BP","regulation of peptidase activity","GO:0052547",{"v":5649330.2247678,"d":"5.65E+06"},467,235,26,18117,"AGER,AIM2,APP,SERPINB9,SERPINE1,SERPINF1,P2RX1,F3,FN1,GRN,HGF,C3,SNCA,PPARG,STAT3,PTGS2,HMGB1,HSPD1,JAK2,LGALS9,LXN,LYN,THBS1,TIMP1,UACA,DDX3X"]
["GO:BP","positive regulation of cellular biosynthetic process","GO:0031328",{"v":575811.089150538,"d":"5.76E+05"},1967,235,59,18117,"MECOM,EGFR,ELF3,ABCD1,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,ASH1L,ATM,HGF,SLC11A1,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKCQ,PRKD1,PTAFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HYAL2,ICAM1,IGF1,IL18,IL33,JAK2,KPNA6,LDLR,MAPK14,RBPJ,REL,TGFB1,THBS1,TLR2,TLR4,CCL5,CD28,CD81,TNIP1,CEBPB,CIITA,CSRP3,DHX9,CX3CL1,DDX3X,DUOXA1"]
["GO:BP","positive regulation of ion transport","GO:0043270",{"v":5800930.25434853,"d":"5.80E+06"},694,235,32,18117,"EGFR,APOE,NR1H3,P2RX1,P2RX7,GJA1,C3,PLA2G4A,SNCA,PPARD,STK39,PRKCZ,PRKD1,PTAFR,PTGS2,NFKBIA,HYAL2,IGF1,ITGAM,JAK2,LPCAT3,MAPK14,TLR2,TLR4,CCL4,CCL5,CCR2,CD81,CEBPB,CTSS,DHX9,CX3CL1"]
["GO:BP","regulation of endothelial cell migration","GO:0010594",{"v":58976031.8726498,"d":"5.90E+07"},244,235,19,18117,"EPHA2,ADAM17,APOE,SERPINF1,NOTCH1,PIK3CG,FGFR1,GRN,HDAC9,SLIT2,PPARG,STAT5A,PRCP,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,THBS1"]
["GO:BP","regulation of stress-activated MAPK cascade","GO:0032872",{"v":5903119.88203403,"d":"5.90E+06"},190,235,17,18117,"MECOM,EGFR,AGER,MFHAS1,APP,PDCD4,GSTP1,HGF,SIRPA,SLAMF1,PJA2,HMGB1,RASGRP1,TLR4,TRPV4,ULK4,CYLD"]
["GO:BP","mast cell degranulation","GO:0043303",{"v":5911430.72656864,"d":"5.91E+06"},48,235,10,18117,"PIK3CG,SNAP23,PTGDR,HMOX1,KIT,LGALS9,LYN,RASGRP1,CD300A,UNC13D"]
["GO:BP","aromatic compound biosynthetic process","GO:0019438",{"v":6418304.24281199,"d":"6.42E+06"},4278,235,98,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,ENPP3,ABCD1,AGER,AIM2,AK7,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","regulation of nucleobase-containing compound metabolic process","GO:0019219",{"v":6872898.13840656,"d":"6.87E+06"},4091,235,95,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,PARP4,PDCD4,PDE2A,BCL6,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DROSHA"]
["GO:BP","transcription, DNA-templated","GO:0006351",{"v":6921128.21073974,"d":"6.92E+06"},3714,235,89,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,BCL6,C5AR1,FABP4,FANCA,FANCD2,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","nucleic acid-templated transcription","GO:0097659",{"v":7006751.96696149,"d":"7.01E+06"},3715,235,89,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,BCL6,C5AR1,FABP4,FANCA,FANCD2,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","negative regulation of transport","GO:0051051",{"v":7594284.72770573,"d":"7.59E+06"},474,235,26,18117,"APOE,APPL2,NOTCH1,NR1H3,GJA1,SIRPA,SNCA,STK39,PRKD1,PTGS2,PXK,NFKB1,HMGB1,HMOX1,ICAM1,LGALS9,LRRK2,TGFB1,THBS1,TLR2,CCR2,CD200,CD300A,CD47,TNFRSF1B,VPS35"]
["GO:BP","regulation of system process","GO:0044057",{"v":7594284.72770573,"d":"7.59E+06"},623,235,30,18117,"EDNRB,EGFR,ACE,AGER,MGLL,APOE,APP,NOTCH1,NR1H3,P2RX1,PIK3CG,GJA1,HGF,CALCRL,PPARA,STK39,PRKCA,PRKCZ,PTAFR,PTGS2,ICAM1,IGF1,JAK2,KIT,LPCAT3,LRRK2,TNFRSF1B,CSRP3,CTSC,DICER1"]
["GO:BP","cellular response to lipoprotein particle stimulus","GO:0071402",{"v":7630048.4995589,"d":"7.63E+06"},36,235,9,18117,"ADAM17,APOE,FCER1G,PPARG,LDLR,LPL,TLR4,CD68,CD81"]
["GO:BP","positive regulation of adaptive immune response","GO:0002821",{"v":7726728.78068737,"d":"7.73E+06"},101,235,13,18117,"C3,SLC11A1,PLA2G4A,PRKCQ,PRKCZ,NFKBID,HSPD1,IL18,IL18R1,IL1R1,CCR2,CD28,CD81"]
["GO:BP","positive regulation of leukocyte mediated immunity","GO:0002705",{"v":7871484.07238368,"d":"7.87E+06"},122,235,14,18117,"C3,STAP1,STAT5B,PRKCZ,PTAFR,HSPD1,IL18,IL18R1,IL18RAP,IL1R1,ITGAM,RASGRP1,CD28,CD81"]
["GO:BP","negative regulation of intracellular signal transduction","GO:1902532",{"v":8199241.85025757,"d":"8.20E+06"},549,235,28,18117,"MECOM,EPHA2,APOE,RORA,P2RX7,ASH1L,ATM,PDCD4,PDE2A,BCL6,GSTP1,SIRPA,SLIT2,PPARA,PTGS2,PTPN2,HYAL2,LRRK2,LYN,MAPK14,THBS1,TLR4,CD300A,TNFAIP3,TNIP1,UACA,CYLD,DDX3X"]
["GO:BP","regulation of secretion by cell","GO:1903530",{"v":8592933.54177683,"d":"8.59E+06"},588,235,29,18117,"EGFR,ALOX5,APOE,SDC1,NOTCH1,NR1H3,P2RX1,GJA1,PLA2G4A,SNCA,PPARD,PRKCA,PTAFR,HMOX1,IGF1,ITGAM,JAK2,LGALS9,LRRK2,LYN,TCIRG1,TLR2,TLR4,CCL5,CCR2,CD200,CD300A,TNFRSF1B,UNC13D"]
["GO:BP","JNK cascade","GO:0007254",{"v":8613583.74807879,"d":"8.61E+06"},195,235,17,18117,"MECOM,EGFR,AGER,MFHAS1,APP,PDCD4,GSTP1,SIRPA,SLAMF1,PJA2,HMGB1,IRAK2,RASGRP1,TLR4,TRPV4,ULK4,CYLD"]
["GO:BP","regulation of body fluid levels","GO:0050878",{"v":8864956.16667638,"d":"8.86E+06"},514,235,27,18117,"EDNRB,APOE,SCNN1B,SERPINE1,NR1H3,P2RX1,P2RX7,AXL,PIK3CG,F3,F8,FCER1G,FN1,GJA1,PLA2G4A,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,HYAL2,JAK2,LYN,THBS1,TLR4,TRPV4"]
["GO:BP","extrinsic apoptotic signaling pathway","GO:0097191",{"v":9336693.81448589,"d":"9.34E+06"},223,235,18,18117,"SERPINE1,P2RX7,FGFR1,GSTP1,HGF,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,IL33,JAK2,THBS1,TNFAIP3,TNFRSF1B,CX3CL1,CYLD,DDX3X"]
["GO:BP","organic cyclic compound biosynthetic process","GO:1901362",{"v":9473512.85887047,"d":"9.47E+06"},4439,235,100,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,ENPP3,ABCD1,AGER,AIM2,AK7,AKNA,ALOX5,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,LPCAT3,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","blood circulation","GO:0008015",{"v":9538966.21165877,"d":"9.54E+06"},553,235,28,18117,"EDNRA,EDNRB,EGFR,ACE,AGER,APOE,SCNN1B,OLR1,P2RX1,PDE2A,PIK3CG,GJA1,SLIT2,PPARA,PPARG,STK39,PRCP,PTAFR,PTGS1,PTGS2,HMOX1,ICAM1,JAK2,RARRES2,CDH5,TRPV4,CSRP3,CTNNBIP1"]
["GO:BP","positive regulation of smooth muscle cell proliferation","GO:0048661",{"v":973177.810846258,"d":"9.73E+05"},103,235,13,18117,"EGFR,GJA1,CALCRL,PTAFR,PTGS2,HMOX1,IGF1,IL18,JAK2,TGM2,THBS1,CCL5,CX3CL1"]
["GO:BP","negative regulation of cellular metabolic process","GO:0031324",{"v":9750847.01689021,"d":"9.75E+06"},2719,235,72,18117,"MCPH1,MECOM,EDNRB,EIF2AK1,ELF3,ABCD1,MFHAS1,APOE,APP,APPL2,SERPINB9,SERPINE1,SERPINF1,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,PDCD4,PDE2A,PIK3CG,BCL6,FABP4,GJA1,GSTP1,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,PPARA,PPARD,PPARG,SOCS3,STAP1,STAT3,PRKCZ,PTGIS,PTGS2,PTPN2,NFKB1,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,IGF1,IL1R2,IL33,ITGAM,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RBPJ,RELB,TGFB1,THBS1,TIMP1,CD300A,TNFAIP3,TRPV4,CEBPB,CIITA,CTNNBIP1,DHX9,DICER1,DDX3X"]
["GO:BP","phosphatidylinositol-mediated signaling","GO:0048015",{"v":9951528.81751199,"d":"9.95E+06"},197,235,17,18117,"EGFR,PIK3AP1,PIK3CG,FGFR1,FN1,HGF,PPARD,PTAFR,IGF1,IL18,JAK2,KIT,LYN,RASGRP1,CCL5,CD28,CSF1R"]
["GO:BP","negative regulation of immune effector process","GO:0002698",{"v":106631980.202517,"d":"1.07E+08"},125,235,14,18117,"ENPP3,SERPINB9,RPS19,BCL6,GRN,HAVCR2,HMOX1,IL2RA,IL33,LGALS9,CCR2,CD300A,CD47,CD96"]
["GO:BP","positive regulation of peptidyl-tyrosine phosphorylation","GO:0050731",{"v":107205445.90373,"d":"1.07E+08"},198,235,17,18117,"ACE,ADAM17,GPRC5B,HGF,SOCS3,STAP1,STAT3,ICAM1,IGF1,IL18,JAK2,KIT,LYN,RICTOR,CCL5,CD81,CSF1R"]
["GO:BP","regulation of production of molecular mediator of immune response","GO:0002700",{"v":108076404.811301,"d":"1.08E+08"},148,235,15,18117,"BCL6,GPRC5B,PRKCZ,HMOX1,IL18,IL18R1,IL1R1,IL33,TLR4,CCR2,CD28,CD81,CD96,TNFRSF1B,HK1"]
["GO:BP","monocyte chemotaxis","GO:0002548",{"v":11216712.9939994,"d":"1.12E+07"},67,235,11,18117,"SERPINE1,RPS19,SLIT2,PLA2G7,HMGB1,LYN,CCL4,CCL5,CCR2,CX3CL1,CXCL17"]
["GO:BP","positive regulation of cellular component organization","GO:0051130",{"v":118458976.410104,"d":"1.18E+08"},1153,235,42,18117,"EPHA2,APOE,APP,APPL2,SDC1,SERPINE1,SERPINF1,RPS6KA5,P2RX7,ATM,AXL,BCL6,FN1,GBP5,GRN,HCK,HGF,C3,SLIT2,CAMK1D,SNCA,PPARG,STAP1,PRKCQ,PRKD1,ICAM1,IGF1,IL1RAP,KIT,LRRK2,LYN,MAPK14,RICTOR,TGFB1,TLR4,CD28,CD47,CDH5,TRPV4,VPS35,CX3CL1,DDX3X"]
["GO:BP","circulatory system process","GO:0003013",{"v":12345019.1913379,"d":"1.23E+07"},637,235,30,18117,"EDNRA,EDNRB,EGFR,ABCC1,ACE,AGER,APOE,SCNN1B,OLR1,P2RX1,PDE2A,PIK3CG,GJA1,SLC7A2,SLIT2,PPARA,PPARG,STK39,PRCP,PTAFR,PTGS1,PTGS2,HMOX1,ICAM1,JAK2,RARRES2,CDH5,TRPV4,CSRP3,CTNNBIP1"]
["GO:BP","positive regulation of interleukin-10 production","GO:0032733",{"v":124477841.237527,"d":"1.24E+08"},38,235,9,18117,"HGF,STAT3,PRKCZ,HMGB1,HSPD1,LGALS9,TLR2,TLR4,CD28"]
["GO:BP","vascular process in circulatory system","GO:0003018",{"v":125145820.48834,"d":"1.25E+08"},256,235,19,18117,"EDNRA,EDNRB,EGFR,ABCC1,ACE,AGER,APOE,SCNN1B,P2RX1,PDE2A,GJA1,SLC7A2,SLIT2,PTAFR,PTGS2,ICAM1,CDH5,TRPV4,CTNNBIP1"]
["GO:BP","CD4-positive, alpha-beta T cell differentiation involved in immune response","GO:0002294",{"v":131038724.168769,"d":"1.31E+08"},68,235,11,18117,"RORA,BCL6,SPN,STAT3,PRKCZ,NFKBID,HMGB1,IL18,IL18R1,LGALS9,RELB"]
["GO:BP","inositol lipid-mediated signaling","GO:0048017",{"v":133156057.560873,"d":"1.33E+08"},201,235,17,18117,"EGFR,PIK3AP1,PIK3CG,FGFR1,FN1,HGF,PPARD,PTAFR,IGF1,IL18,JAK2,KIT,LYN,RASGRP1,CCL5,CD28,CSF1R"]
["GO:BP","peptidyl-amino acid modification","GO:0018193",{"v":143542831.686616,"d":"1.44E+08"},1303,235,45,18117,"MECOM,EGFR,EPHA2,ACE,ADAM17,APP,RPS6KA5,ASH1L,ATM,AXL,FGFR1,GPRC5B,HCK,HDAC9,HGF,CAMK1D,CAMK4,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGS2,PTPN2,HYAL2,ICAM1,IGF1,IL18,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RICTOR,TGFB1,TGM2,CCL5,CD300A,CD81,CSF1R"]
["GO:BP","regulation of monocyte chemotaxis","GO:0090025",{"v":150221840.361978,"d":"1.50E+08"},27,235,8,18117,"SERPINE1,SLIT2,PLA2G7,HMGB1,LYN,CCL5,CCR2,CXCL17"]
["GO:BP","negative regulation of nitrogen compound metabolic process","GO:0051172",{"v":150940112.552593,"d":"1.51E+08"},2518,235,68,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,MFHAS1,APOE,APP,SERPINB9,SERPINE1,SERPINF1,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,PDCD4,PDE2A,BCL6,FABP4,GJA1,GSTP1,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT3,PRKCZ,PTGIS,PTGS2,PTPN2,NFKB1,HMGB1,HMGB2,HYAL2,IGF1,IL1R2,IL33,ITGAM,LDLR,LRRK2,LXN,LYN,MAPK14,MAPKAPK2,RBPJ,RELB,TGFB1,THBS1,TIMP1,CD300A,TNFAIP3,TRPV4,CEBPB,CIITA,CTNNBIP1,DHX9,DICER1,DDX3X"]
["GO:BP","alpha-beta T cell activation involved in immune response","GO:0002287",{"v":15238480.832765,"d":"1.52E+07"},69,235,11,18117,"RORA,BCL6,SPN,STAT3,PRKCZ,NFKBID,HMGB1,IL18,IL18R1,LGALS9,RELB"]
["GO:BP","alpha-beta T cell differentiation involved in immune response","GO:0002293",{"v":15238480.832765,"d":"1.52E+07"},69,235,11,18117,"RORA,BCL6,SPN,STAT3,PRKCZ,NFKBID,HMGB1,IL18,IL18R1,LGALS9,RELB"]
["GO:BP","regulation of cellular response to stress","GO:0080135",{"v":15878323.5999058,"d":"1.59E+07"},725,235,32,18117,"MECOM,EGFR,EIF2AK1,ABCD1,AGER,ALOX5,MFHAS1,APP,NR1H3,NUPR1,ATM,PDCD4,BCL6,GRN,GSTP1,HGF,SIRPA,SLAMF1,PJA2,PTGS2,PTPN2,HMGB1,LPCAT3,LRRK2,LYN,MAPKAPK2,RASGRP1,TLR4,TRPV4,ULK4,DHX9,CYLD"]
["GO:BP","endothelial cell migration","GO:0043542",{"v":159002130.154667,"d":"1.59E+08"},290,235,20,18117,"EPHA2,ADAM17,APOE,SERPINF1,NOTCH1,PIK3CG,FGFR1,GRN,HDAC9,SLIT2,PPARG,STAT5A,PRCP,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,THBS1,CDH5"]
["GO:BP","endothelial cell proliferation","GO:0001935",{"v":164747041.516725,"d":"1.65E+08"},204,235,17,18117,"EPHA2,ADAM17,ALOX5,APOE,F3,FGFR1,GJA1,PPARG,STAT3,STAT5A,PRKCA,PRKD1,HMGB1,HMGB2,HMOX1,RICTOR,THBS1"]
["GO:BP","cellular nitrogen compound biosynthetic process","GO:0044271",{"v":166577598.153565,"d":"1.67E+08"},5017,235,108,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,ABCD1,ACER3,AGER,AIM2,AK7,AKNA,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,SGMS1,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SIRPA,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD47,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CERS6,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","cellular lipid metabolic process","GO:0044255",{"v":16731852.1400434,"d":"1.67E+07"},1075,235,40,18117,"EGFR,ABCD1,ABHD12,ACER3,ALOX5,ALOX5AP,MGLL,APOE,APPL2,AOAH,SDC1,NR1H3,P2RX1,ATM,PIK3CG,SGMS1,FABP4,GPX4,GSTP1,C3,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,SOCS3,PRKD1,PTGIS,PTGS1,PTGS2,KIT,LDLR,LPCAT3,LPL,MAPK14,RARRES2,CERS6,CSF1R,DAGLB"]
["GO:BP","lipid metabolic process","GO:0006629",{"v":16731852.1400434,"d":"1.67E+07"},1457,235,48,18117,"EGFR,ABCD1,ABHD12,ACER3,ALOX5,ALOX5AP,MGLL,APOE,APP,APPL2,AOAH,SDC1,RORA,NR1H3,P2RX1,ATM,PIK3CG,SGMS1,FABP4,GPX4,GSTP1,C3,PLA2G4A,PLA2G7,PLD3,SNCA,PPARA,PPARD,PPARG,SOCS3,STAT5B,PRKD1,PTGIS,PTGS1,PTGS2,NFKB1,KIT,LDLR,LIPA,LPCAT3,LPL,LYN,MAPK14,RARRES2,CD81,CERS6,CSF1R,DAGLB"]
["GO:BP","I-kappaB kinase/NF-kappaB signaling","GO:0007249",{"v":16731852.1400434,"d":"1.67E+07"},291,235,20,18117,"RORA,ASH1L,GJA1,GPRC5B,GSTP1,SIRPA,PRKD1,NFKBIA,HMOX1,IRAK2,LGALS9,LY96,REL,RELB,TGM2,TLR2,TLR4,TNFAIP3,TNIP1,CX3CL1"]
["GO:BP","regulation of pattern recognition receptor signaling pathway","GO:0062207",{"v":168616037.040826,"d":"1.69E+08"},108,235,13,18117,"MFHAS1,APPL2,NR1H3,PJA2,HMGB1,LY96,LYN,TLR1,TLR2,TLR4,CD300A,TNFAIP3,DDX3X"]
["GO:BP","cellular extravasation","GO:0045123",{"v":175445115.721584,"d":"1.75E+08"},70,235,11,18117,"AGER,PIK3CG,SIRPA,SPN,PTAFR,ICAM1,IL1R1,JAM3,CCR2,CD47,CX3CL1"]
["GO:BP","positive regulation of peptidase activity","GO:0010952",{"v":175445115.721584,"d":"1.75E+08"},205,235,17,18117,"AGER,AIM2,APP,P2RX1,F3,FN1,GRN,SNCA,PPARG,STAT3,HMGB1,HSPD1,JAK2,LGALS9,LYN,UACA,DDX3X"]
["GO:BP","protein modification process","GO:0036211",{"v":180101089.24738,"d":"1.80E+08"},4041,235,93,18117,"MECOM,EDNRB,EGFR,EIF2AK1,EPHA2,ABHD12,ABR,ACE,ADAM17,AGER,MFHAS1,APOE,APP,RPS6KA5,NUPR1,ASH1L,ATM,AXL,PARP4,PDCD4,PIK3CG,BCL6,BCR,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,PJA2,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKBIA,HMGB1,HYAL2,ICAM1,IGF1,IL18,IL33,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD300A,CD81,CDH5,CDK19,TNFAIP3,TNIP1,ULK4,CIITA,CSF1,CSF1R,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","cellular protein modification process","GO:0006464",{"v":180101089.24738,"d":"1.80E+08"},4041,235,93,18117,"MECOM,EDNRB,EGFR,EIF2AK1,EPHA2,ABHD12,ABR,ACE,ADAM17,AGER,MFHAS1,APOE,APP,RPS6KA5,NUPR1,ASH1L,ATM,AXL,PARP4,PDCD4,PIK3CG,BCL6,BCR,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,PJA2,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKBIA,HMGB1,HYAL2,ICAM1,IGF1,IL18,IL33,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD300A,CD81,CDH5,CDK19,TNFAIP3,TNIP1,ULK4,CIITA,CSF1,CSF1R,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","cellular localization","GO:0051641",{"v":184550661.578287,"d":"1.85E+08"},3541,235,85,18117,"MCPH1,EGFR,EPHA2,ABCD1,AGER,ALOX5,MFHAS1,APOE,APP,APPL2,SERPINE1,RPS19,OLR1,P2RX1,P2RX7,ATM,PIK3CG,C5AR1,F8,FCER1G,FN1,FPR1,GBP5,GJA1,GRN,GSTP1,HCK,HGF,C3,SIRPA,SLC11A1,SNAP23,SNCA,PPARD,STAT3,PRCP,PRKCZ,PRKD1,PTAFR,PTGDR,PTGS2,NFKB1,NFKBIA,HMGB1,HMOX1,HSPD1,HYAL2,IGF1,ITGAM,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LRRK2,LYN,MAPK14,RARRES2,RASGRP1,TBC1D23,TCIRG1,TGFB1,THBS1,TIMP1,TLR2,CCR2,CD300A,CD47,CD68,CD81,TNFAIP3,TNFRSF1B,TRPV4,UNC13D,VPS35,CSRP3,CTSC,CTSS,DHX9,CX3CL1,CYBB,DDX3X,DUOXA1,HK1"]
["GO:BP","adaptive thermogenesis","GO:1990845",{"v":19659688.5301135,"d":"1.97E+07"},155,235,15,18117,"ADAM17,APPL2,NOTCH1,NR1H3,FABP4,GJA1,IL18,IL18R1,JAK2,RBPJ,TLR4,CCR2,TRPV4,CEBPB,CMKLR1"]
["GO:BP","cell-cell signaling","GO:0007267",{"v":210355831.939989,"d":"2.10E+08"},1722,235,53,18117,"EGFR,ABR,AGER,ALOX5,APOE,APP,SDC1,NOTCH1,P2RX1,P2RX7,BCR,GJA1,GPRC5B,HGF,C3,PLA2G4A,PMP22,SNAP23,SNCA,PPARD,STAB1,STAT3,PRKCA,PRKCZ,PSMA1,PTGS2,PXK,NFKB1,IL18,IL1RAP,ITGAM,JAK2,KIT,LRRK2,LYN,MAPK14,RBPJ,TCIRG1,TLR2,CCL4,CCL5,CCR2,CD68,TNFAIP3,TNFRSF1B,TRPV4,VPS35,CNR2,CTNNBIP1,CX3CL1,CYLD,DAGLB,DDX3X"]
["GO:BP","negative regulation of lymphocyte activation","GO:0051250",{"v":214246236.587498,"d":"2.14E+08"},156,235,15,18117,"ATM,AXL,BCL6,HAVCR2,SPN,PTPN2,HMGB1,IDO1,IL2RA,LGALS9,LYN,TGFB1,CD300A,TNFAIP3,CEBPB"]
["GO:BP","regulation of anatomical structure morphogenesis","GO:0022603",{"v":230872379.49125,"d":"2.31E+08"},1042,235,39,18117,"EPHA2,ADAMTS12,ALOX5,SERPINE1,SERPINF1,NOTCH1,BCL6,C5AR1,F3,FN1,GJA1,GRN,HCK,HGF,C3,SLIT2,PPARG,STAB1,STAT3,PRKCA,PRKD1,PSMA1,PTGIS,HMGB1,HMOX1,ICAM1,KIT,LRRK2,TGFB1,THBS1,CCR2,CDH5,TNFAIP3,UNC13D,VPS35,CSF1,CSF1R,CX3CL1,CYBB"]
["GO:BP","positive regulation of interleukin-12 production","GO:0032735",{"v":24638227.6747659,"d":"2.46E+07"},41,235,9,18117,"AGER,HMGB1,HSPD1,IDO1,IL16,LGALS9,MAPK14,TLR2,TLR4"]
["GO:BP","regulation of cellular macromolecule biosynthetic process","GO:2000112",{"v":264816415.593379,"d":"2.65E+08"},4071,235,93,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,BCL6,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD81,TNFAIP3,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","tolerance induction","GO:0002507",{"v":272149517.873135,"d":"2.72E+08"},29,235,8,18117,"HAVCR2,HMGB1,IDO1,IL2RA,LGALS9,LYN,TGFB1,TNFAIP3"]
["GO:BP","negative regulation of tumor necrosis factor production","GO:0032720",{"v":273281671.361544,"d":"2.73E+08"},73,235,11,18117,"AXL,GSTP1,HAVCR2,SIRPA,SLAMF1,IGF1,LGALS9,TLR4,TNFAIP3,DICER1,CX3CL1"]
["GO:BP","regulation of leukocyte mediated cytotoxicity","GO:0001910",{"v":31679090.3856978,"d":"3.17E+07"},74,235,11,18117,"AGER,SERPINB9,HAVCR2,STAP1,STAT5B,ICAM1,IL18RAP,ITGAM,LGALS9,RASGRP1,DNASE1"]
["GO:BP","regulation of endopeptidase activity","GO:0052548",{"v":320882517.233941,"d":"3.21E+08"},437,235,24,18117,"AGER,AIM2,APP,SERPINB9,SERPINE1,SERPINF1,P2RX1,F3,HGF,C3,SNCA,PPARG,STAT3,PTGS2,HMGB1,HSPD1,JAK2,LGALS9,LXN,LYN,THBS1,TIMP1,UACA,DDX3X"]
["GO:BP","phosphatidylinositol 3-kinase signaling","GO:0014065",{"v":32727235.2486701,"d":"3.27E+07"},161,235,15,18117,"EGFR,PIK3AP1,PIK3CG,FGFR1,FN1,HGF,PPARD,IGF1,IL18,JAK2,KIT,LYN,RASGRP1,CCL5,CD28"]
["GO:BP","positive regulation of angiogenesis","GO:0045766",{"v":33268893.480134,"d":"3.33E+07"},187,235,16,18117,"SERPINE1,C5AR1,F3,GRN,HGF,C3,STAT3,PRKCA,PRKD1,PTGIS,HMGB1,HMOX1,THBS1,CDH5,CX3CL1,CYBB"]
["GO:BP","positive regulation of vasculature development","GO:1904018",{"v":33268893.480134,"d":"3.33E+07"},187,235,16,18117,"SERPINE1,C5AR1,F3,GRN,HGF,C3,STAT3,PRKCA,PRKD1,PTGIS,HMGB1,HMOX1,THBS1,CDH5,CX3CL1,CYBB"]
["GO:BP","negative regulation of cell adhesion","GO:0007162",{"v":342845778.191514,"d":"3.43E+08"},304,235,20,18117,"AKNA,SERPINE1,NOTCH1,BCL6,HAVCR2,PPARA,SPN,PTPN2,HMGB1,IDO1,IL2RA,JAK2,JAM3,LGALS9,TGFB1,THBS1,CD300A,TRPV4,CEBPB,CX3CL1"]
["GO:BP","epithelial cell migration","GO:0010631",{"v":35380830.5463771,"d":"3.54E+07"},370,235,22,18117,"EPHA2,ADAM17,APOE,SERPINF1,NOTCH1,PIK3CG,FGFR1,GRN,HDAC9,SLIT2,PPARD,PPARG,STAT5A,PRCP,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,KIT,THBS1,CDH5"]
["GO:BP","regulation of blood vessel endothelial cell migration","GO:0043535",{"v":35380830.5463771,"d":"3.54E+07"},162,235,15,18117,"EPHA2,ADAM17,APOE,NOTCH1,FGFR1,HDAC9,PPARG,STAT5A,PRCP,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,THBS1"]
["GO:BP","regulation of endothelial cell proliferation","GO:0001936",{"v":356927644.031243,"d":"3.57E+08"},188,235,16,18117,"ADAM17,ALOX5,APOE,F3,FGFR1,GJA1,PPARG,STAT3,STAT5A,PRKCA,PRKD1,HMGB1,HMGB2,HMOX1,RICTOR,THBS1"]
["GO:BP","negative regulation of tumor necrosis factor superfamily cytokine production","GO:1903556",{"v":36116036.2637679,"d":"3.61E+07"},75,235,11,18117,"AXL,GSTP1,HAVCR2,SIRPA,SLAMF1,IGF1,LGALS9,TLR4,TNFAIP3,DICER1,CX3CL1"]
["GO:BP","epithelium migration","GO:0090132",{"v":40830001.3502503,"d":"4.08E+07"},373,235,22,18117,"EPHA2,ADAM17,APOE,SERPINF1,NOTCH1,PIK3CG,FGFR1,GRN,HDAC9,SLIT2,PPARD,PPARG,STAT5A,PRCP,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,KIT,THBS1,CDH5"]
["GO:BP","regulation of toll-like receptor 2 signaling pathway","GO:0034135",{"v":426070412.259609,"d":"4.26E+08"},12,235,6,18117,"MFHAS1,PJA2,HMGB1,LYN,TLR1,TNFAIP3"]
["GO:BP","regulation of interleukin-4 production","GO:0032673",{"v":477013291.358613,"d":"4.77E+08"},31,235,8,18117,"FCER1G,HAVCR2,PRKCQ,PRKCZ,IL33,LGALS9,CD28,CEBPB"]
["GO:BP","cellular biosynthetic process","GO:0044249",{"v":485264730.80973,"d":"4.85E+08"},6154,235,123,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,ABCD1,ACER3,AGER,AIM2,AK7,AKNA,ALOX5,ALOX5AP,MGLL,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,PIK3CG,BCL6,SGMS1,C5AR1,FABP4,FANCA,FANCD2,GJA1,GPX4,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,CAMK1D,CAMK4,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS1,PTGS2,PTPN2,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD47,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CERS6,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DAGLB,DDX3X,DUOXA1"]
["GO:BP","tissue migration","GO:0090130",{"v":54326407.0620842,"d":"5.43E+07"},379,235,22,18117,"EPHA2,ADAM17,APOE,SERPINF1,NOTCH1,PIK3CG,FGFR1,GRN,HDAC9,SLIT2,PPARD,PPARG,STAT5A,PRCP,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,KIT,THBS1,CDH5"]
["GO:BP","negative regulation of cell-cell adhesion","GO:0022408",{"v":555500946.90107,"d":"5.56E+08"},194,235,16,18117,"AKNA,NOTCH1,BCL6,HAVCR2,PPARA,SPN,PTPN2,HMGB1,IDO1,IL2RA,JAK2,LGALS9,TGFB1,CD300A,TRPV4,CEBPB"]
["GO:BP","T cell mediated immunity","GO:0002456",{"v":5680988.15253371,"d":"5.68E+06"},98,235,12,18117,"AGER,PRKCZ,HMGB1,HSPD1,ICAM1,IL18,IL18R1,IL1R1,CCR2,CD81,TNFRSF1B,CTSC"]
["GO:BP","cell development","GO:0048468",{"v":60356669.9325131,"d":"6.04E+07"},2100,235,59,18117,"EDNRA,EDNRB,EGFR,EPHA2,AGER,APOE,APP,APPL2,SDC1,SERPINF1,RPS19,RPS6KA5,NOTCH1,NOTCH2,ATM,ATRN,AXL,PDCD4,PDE2A,BCL6,C5AR1,FN1,GJA1,GRN,GSTP1,HDAC9,HGF,C3,SLIT2,CAMK1D,PPARA,PPARG,PRKCA,PRKCQ,PRKCZ,PRKD1,HMGB1,HMGB2,ICAM1,IGF1,JAK2,JAM3,KIT,LDLR,LRRK2,LYN,TBC1D23,TGFB1,TLR2,TLR4,CDH5,TNFRSF1B,TRPV4,ULK4,UNC13D,CSF1R,CSRP3,DICER1,CX3CL1"]
["GO:BP","cold-induced thermogenesis","GO:0106106",{"v":62093519.0723026,"d":"6.21E+07"},144,235,14,18117,"ADAM17,APPL2,NOTCH1,NR1H3,FABP4,GJA1,IL18,IL18R1,JAK2,RBPJ,TLR4,CCR2,CEBPB,CMKLR1"]
["GO:BP","interleukin-4 production","GO:0032633",{"v":62093519.0723026,"d":"6.21E+07"},32,235,8,18117,"FCER1G,HAVCR2,PRKCQ,PRKCZ,IL33,LGALS9,CD28,CEBPB"]
["GO:BP","regulation of macrophage derived foam cell differentiation","GO:0010743",{"v":62093519.0723026,"d":"6.21E+07"},32,235,8,18117,"NR1H3,PPARA,PPARG,NFKB1,NFKBIA,IL18,LPL,CSF1"]
["GO:BP","regulation of cold-induced thermogenesis","GO:0120161",{"v":62093519.0723026,"d":"6.21E+07"},144,235,14,18117,"ADAM17,APPL2,NOTCH1,NR1H3,FABP4,GJA1,IL18,IL18R1,JAK2,RBPJ,TLR4,CCR2,CEBPB,CMKLR1"]
["GO:BP","response to steroid hormone","GO:0048545",{"v":6478954.47362329,"d":"6.48E+06"},349,235,21,18117,"EGFR,SCNN1B,SDC1,SERPINF1,NOTCH1,NR1H3,GSTP1,SLIT2,PPARA,PPARD,PTAFR,PTGS2,HMGB1,HMGB2,HSPD1,ICAM1,JAK2,TGFB1,THBS1,TLR2,CYBB"]
["GO:BP","activation of immune response","GO:0002253",{"v":67464124.7835502,"d":"6.75E+07"},568,235,27,18117,"AIM2,APPL2,RPS6KA5,C5AR1,FCER1G,FPR1,FPR3,HCK,C3,STAP1,PRKCQ,PSMA1,PTPN2,NFKB1,NFKBID,HMGB1,LYN,RELB,THEMIS2,TLR4,CD28,CD300A,CD47,CD81,ZBP1,CFH,CMKLR1"]
["GO:BP","positive regulation of small molecule metabolic process","GO:0062013",{"v":67593585.9306144,"d":"6.76E+07"},145,235,14,18117,"ABCD1,APP,NR1H3,P2RX7,SNCA,PPARA,PPARD,PPARG,STAT3,PTAFR,PTGS2,PTPN2,HMGB1,IGF1"]
["GO:BP","protein kinase B signaling","GO:0043491",{"v":71091562.5843531,"d":"7.11E+07"},286,235,19,18117,"EGFR,EPHA2,MFHAS1,AXL,PIK3AP1,PIK3CG,F3,FGFR1,HGF,PPARA,HYAL2,IGF1,IL18,KIT,RICTOR,THBS1,CCL5,CD28,CX3CL1"]
["GO:BP","biosynthetic process","GO:0009058",{"v":75548901.2936271,"d":"7.55E+07"},6340,235,125,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,ABCD1,ACER3,AGER,AIM2,AK7,AKNA,ALOX5,ALOX5AP,MGLL,APOE,APP,SDC1,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,PIK3CG,BCL6,SGMS1,C5AR1,FABP4,FANCA,FANCD2,GJA1,GPX4,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,CAMK1D,CAMK4,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS1,PTGS2,PTPN2,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD47,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CERS6,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DAGLB,DDX3X,DUOXA1"]
["GO:BP","regulation of lipase activity","GO:0060191",{"v":79032136.7712006,"d":"7.90E+07"},101,235,12,18117,"EDNRA,EGFR,NR1H3,C5AR1,FGFR1,HDAC9,SNCA,PRKCZ,PTAFR,KIT,LPL,CCL5"]
["GO:BP","biological process involved in symbiotic interaction","GO:0044403",{"v":83659969.3754361,"d":"8.37E+07"},1001,235,37,18117,"EGFR,EPHA2,APOE,SERPINB9,RPS19,NOTCH1,AXL,FN1,HCK,SLAMF1,PPARA,STAT3,NFKBIA,HMGB1,HSPD1,HYAL2,ICAM1,IL16,ITGB6,KPNA6,LDLR,LGALS9,LYN,RICTOR,CCL4,CCL5,CCR2,CD28,CD81,TNIP1,VPS35,ZBP1,CFH,CIITA,CSF1R,DHX9,DDX3X"]
["GO:BP","icosanoid metabolic process","GO:0006690",{"v":86491120.6444821,"d":"8.65E+07"},124,235,13,18117,"ABCC1,ALOX5,ALOX5AP,MGLL,GPX4,GSTP1,PLA2G4A,PTGIS,PTGS1,PTGS2,MAPKAPK2,TLR2,DAGLB"]
["GO:BP","erythrocyte homeostasis","GO:0034101",{"v":86491120.6444821,"d":"8.65E+07"},124,235,13,18117,"MFHAS1,RPS19,AXL,BCL6,STAT3,STAT5B,PTPN2,HMGB2,HMOX1,JAK2,KIT,LYN,MAPK14"]
["GO:BP","regulation of alpha-beta T cell activation","GO:0046634",{"v":87946883.3947644,"d":"8.79E+07"},102,235,12,18117,"AGER,BCL6,PRKCQ,PRKCZ,NFKBID,HMGB1,IL18,LGALS9,CCR2,CD28,CD300A,CD81"]
["GO:BP","receptor signaling pathway via JAK-STAT","GO:0007259",{"v":90293077.7255964,"d":"9.03E+07"},174,235,15,18117,"NOTCH1,SOCS3,STAT3,STAT5A,STAT5B,PTPN2,IGF1,IL18,JAK2,KIT,LYN,CCL5,CCR2,CD300A,CSF1R"]
["GO:BP","monocarboxylic acid metabolic process","GO:0032787",{"v":94932143.2492703,"d":"9.49E+07"},658,235,29,18117,"ABCD1,ALOX5,ALOX5AP,MGLL,APP,APPL2,AOAH,NR1H3,NUPR1,P2RX7,GPX4,GSTP1,C3,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STAT3,PTGIS,PTGS1,PTGS2,IDO1,IGF1,KIT,LPL,MAPK14,DAGLB,HK1"]
["GO:BP","reproductive structure development","GO:0048608",{"v":1037090591.33828,"d":"1.04E+09"},429,235,23,18117,"SDC1,SERPINF1,NOTCH1,NOTCH2,NUPR1,ASH1L,ATM,AXL,FANCA,GJA1,C3,SLIT2,PPARD,PPARG,SOCS3,STAT5B,PTGS2,HMGB2,ICAM1,KIT,MAPK14,RBPJ,CEBPB"]
["GO:BP","regulation of myeloid cell differentiation","GO:0045637",{"v":1115408244.05664,"d":"1.12E+09"},263,235,18,18117,"NOTCH2,CAMK4,STAT3,STAT5B,PRKCA,PRKCQ,PTPN2,NFKBIA,HMGB1,HMGB2,LYN,MAPK14,TGFB1,THBS1,TLR4,CEBPB,CSF1,CTNNBIP1"]
["GO:BP","reproductive system development","GO:0061458",{"v":1177348911.34252,"d":"1.18E+09"},432,235,23,18117,"SDC1,SERPINF1,NOTCH1,NOTCH2,NUPR1,ASH1L,ATM,AXL,FANCA,GJA1,C3,SLIT2,PPARD,PPARG,SOCS3,STAT5B,PTGS2,HMGB2,ICAM1,KIT,MAPK14,RBPJ,CEBPB"]
["GO:BP","regeneration","GO:0031099",{"v":1264670064.42465,"d":"1.26E+09"},206,235,16,18117,"EGFR,NOTCH1,AXL,C5AR1,GRN,GSTP1,HGF,PPARD,PPARG,HMOX1,IGF1,JAK2,JAM3,TGFB1,CD81,CEBPB"]
["GO:BP","inflammatory response to wounding","GO:0090594",{"v":1293011827.0791,"d":"1.29E+09"},14,235,6,18117,"AGER,ALOX5,GRN,HMOX1,TIMP1,CCR2"]
["GO:BP","regulation of regulatory T cell differentiation","GO:0045589",{"v":1296616998.22898,"d":"1.30E+09"},35,235,8,18117,"BCL6,FANCA,FANCD2,IL2RA,LGALS9,TGFB1,CD28,DROSHA"]
["GO:BP","positive regulation of interferon-gamma production","GO:0032729",{"v":1296616998.22898,"d":"1.30E+09"},66,235,10,18117,"HAVCR2,SLC11A1,HSPD1,IL18,IL18R1,IL1R1,LGALS9,RASGRP1,TLR4,CCR2"]
["GO:BP","response to lipoprotein particle","GO:0055094",{"v":1296616998.22898,"d":"1.30E+09"},35,235,8,18117,"APOE,FCER1G,PPARG,LDLR,LPL,TLR4,CD68,CD81"]
["GO:BP","T-helper cell differentiation","GO:0042093",{"v":1296616998.22898,"d":"1.30E+09"},66,235,10,18117,"RORA,BCL6,SPN,STAT3,PRKCZ,NFKBID,HMGB1,IL18,IL18R1,RELB"]
["GO:BP","negative regulation of innate immune response","GO:0045824",{"v":1296616998.22898,"d":"1.30E+09"},66,235,10,18117,"SERPINB9,RPS19,NR1H3,GRN,HAVCR2,PPARG,PTPN2,LGALS9,CD96,TNFAIP3"]
["GO:BP","cellular response to organic cyclic compound","GO:0071407",{"v":130167246.0555,"d":"1.30E+08"},587,235,27,18117,"EGFR,APP,SCNN1B,SERPINF1,RORA,P2RX7,PDE2A,PIK3CG,GSTP1,SNCA,PPARA,PPARD,PPARG,STAT3,PTAFR,PTGS2,NFKB1,ICAM1,IL18,JAK2,LRRK2,TGFB1,CCL5,VPS35,CEBPB,CIITA,DHX9"]
["GO:BP","CD4-positive, alpha-beta T cell differentiation","GO:0043367",{"v":1319399223.93416,"d":"1.32E+09"},85,235,11,18117,"RORA,BCL6,SPN,STAT3,PRKCZ,NFKBID,HMGB1,IL18,IL18R1,LGALS9,RELB"]
["GO:BP","negative regulation of developmental process","GO:0051093",{"v":1442099266.31277,"d":"1.44E+09"},977,235,36,18117,"EDNRB,EGFR,EPHA2,ADAMTS12,ALOX5,APP,APPL2,SERPINE1,SERPINF1,RORA,NOTCH1,NR1H3,PDCD4,BCL6,GJA1,PPARA,PPARD,PPARG,STAB1,STAT3,STAT5B,PTPN2,NFKBIA,HMGB1,IGF1,IL18,LDLR,LYN,RBPJ,TGFB1,THBS1,TLR2,TLR4,CCR2,TRPV4,DICER1"]
["GO:BP","regulation of acute inflammatory response","GO:0002673",{"v":145672029.799942,"d":"1.46E+08"},50,235,9,18117,"EDNRB,ALOX5AP,ASH1L,PIK3CG,GSTP1,C3,PPARG,PTGS2,DNASE1"]
["GO:BP","leukocyte homeostasis","GO:0001776",{"v":1485858764.31023,"d":"1.49E+09"},86,235,11,18117,"ADAM17,AXL,STAT5B,HMGB1,IL2RA,JAM3,LGALS9,LYN,TCIRG1,TGFB1,TNFAIP3"]
["GO:BP","lipid storage","GO:0019915",{"v":1485858764.31023,"d":"1.49E+09"},86,235,11,18117,"APOE,NR1H3,C3,PPARA,PPARD,PPARG,STAT5B,PTPN2,NFKB1,NFKBIA,LPL"]
["GO:BP","organic substance catabolic process","GO:1901575",{"v":14859184.1079351,"d":"1.49E+07"},2267,235,61,18117,"EGFR,ENPP3,ABCD1,ABHD12,ACE,ACER3,ADAMTS12,ALDH2,MGLL,APOE,APP,AOAH,SDC1,RPS19,NUPR1,P2RX7,ATM,PDE2A,PDE5A,PIK3CG,FABP4,GJA1,SLC11A1,PLA2G4A,PLA2G7,PLD3,SNCA,PPARA,PPARD,STAT3,PRKCA,PSMA1,HMGB1,HMGB2,HMOX1,HYAL2,IDO1,IGF1,IL33,LDLR,LIPA,LPL,LRRK2,MAPK14,MAPKAPK2,RARRES2,TCIRG1,TIMP1,CD81,TNFAIP3,TNFRSF1B,VPS35,CTSC,CTSS,DHX9,DICER1,CYLD,DAGLB,DNASE1,DROSHA,HK1"]
["GO:BP","response to growth factor","GO:0070848",{"v":159702795.421756,"d":"1.60E+08"},759,235,31,18117,"EGFR,EPHA2,ADAM17,ADAMTS12,APP,APPL2,NOTCH1,NOTCH2,PDCD4,PDE2A,FGFR1,GSTP1,HGF,SLIT2,SNCA,PPARA,PPARG,STAT5B,PRKCZ,PRKD1,NDST1,HYAL2,ITGB6,MAPK14,MAPKAPK2,RBPJ,TGFB1,THBS1,CCL5,CDH5,TNFRSF1B"]
["GO:BP","activation of MAPK activity","GO:0000187",{"v":1658309913.88514,"d":"1.66E+09"},156,235,14,18117,"C5AR1,FPR1,HGF,STK39,IGF1,IRAK2,KIT,LRRK2,MAPK14,MAPKAPK2,THBS1,TLR4,CD81,CXCL17"]
["GO:BP","protein autophosphorylation","GO:0046777",{"v":1691213547.86496,"d":"1.69E+09"},240,235,17,18117,"EGFR,EIF2AK1,ACE,ATM,BCR,FGFR1,HCK,CAMK4,STK39,PRKD1,JAK2,KIT,LRRK2,LYN,MAPKAPK2,CSF1R,DDX3X"]
["GO:BP","negative regulation of catalytic activity","GO:0043086",{"v":18289211.3073969,"d":"1.83E+07"},851,235,33,18117,"EDNRB,APOE,APP,SERPINB9,SERPINE1,SERPINF1,NOTCH1,PDCD4,FABP4,GSTP1,HDAC9,HGF,C3,SLIT2,SNCA,PPARG,SOCS3,PRKCZ,PTGS2,PTPN2,PXK,NFKB1,HYAL2,LRRK2,LXN,LYN,THBS1,TIMP1,CCR2,CD300A,TNFAIP3,CNR2,DDX3X"]
["GO:BP","receptor signaling pathway via STAT","GO:0097696",{"v":1854480334.87841,"d":"1.85E+09"},184,235,15,18117,"NOTCH1,SOCS3,STAT3,STAT5A,STAT5B,PTPN2,IGF1,IL18,JAK2,KIT,LYN,CCL5,CCR2,CD300A,CSF1R"]
["GO:BP","viral process","GO:0016032",{"v":1881065448.68737,"d":"1.88E+09"},942,235,35,18117,"EGFR,EPHA2,APOE,RPS19,NOTCH1,AXL,HCK,SLAMF1,PPARA,STAT3,NFKBIA,HMGB1,HSPD1,HYAL2,ICAM1,IL16,ITGB6,KPNA6,LDLR,LGALS9,LYN,RICTOR,CCL4,CCL5,CCR2,CD28,CD81,TNIP1,VPS35,ZBP1,CFH,CIITA,CSF1R,DHX9,DDX3X"]
["GO:BP","foam cell differentiation","GO:0090077",{"v":201216071.788634,"d":"2.01E+08"},37,235,8,18117,"NR1H3,PPARA,PPARG,NFKB1,NFKBIA,IL18,LPL,CSF1"]
["GO:BP","MyD88-dependent toll-like receptor signaling pathway","GO:0002755",{"v":201216071.788634,"d":"2.01E+08"},37,235,8,18117,"HSPD1,IRAK2,LY96,TLR1,TLR2,TLR4,CD300A,TNIP1"]
["GO:BP","macrophage derived foam cell differentiation","GO:0010742",{"v":201216071.788634,"d":"2.01E+08"},37,235,8,18117,"NR1H3,PPARA,PPARG,NFKB1,NFKBIA,IL18,LPL,CSF1"]
["GO:BP","regulation of epithelial cell migration","GO:0010632",{"v":201216071.788634,"d":"2.01E+08"},306,235,19,18117,"EPHA2,ADAM17,APOE,SERPINF1,NOTCH1,PIK3CG,FGFR1,GRN,HDAC9,SLIT2,PPARG,STAT5A,PRCP,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,THBS1"]
["GO:BP","p38MAPK cascade","GO:0038066",{"v":204044402.737632,"d":"2.04E+08"},52,235,9,18117,"AGER,MFHAS1,HGF,PJA2,LGALS9,MAPK14,MAPKAPK2,ULK4,CYLD"]
["GO:BP","regulation of interferon-beta production","GO:0032648",{"v":204044402.737632,"d":"2.04E+08"},52,235,9,18117,"SIRPA,HMGB1,HMGB2,REL,RELB,TLR2,TLR4,DHX9,DDX3X"]
["GO:BP","regulation of extrinsic apoptotic signaling pathway","GO:2001236",{"v":207878311.006836,"d":"2.08E+08"},159,235,14,18117,"SERPINE1,FGFR1,GSTP1,HGF,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,THBS1,TNFAIP3,CX3CL1,CYLD,DDX3X"]
["GO:BP","regulation of small molecule metabolic process","GO:0062012",{"v":211872864.377169,"d":"2.12E+08"},447,235,23,18117,"ABCD1,APOE,APP,APPL2,RORA,NR1H3,NUPR1,P2RX7,SNCA,PPARA,PPARD,PPARG,STAT3,PSMA1,PTAFR,PTGS2,PTPN2,NFKB1,HMGB1,IGF1,KIT,LDLR,LPCAT3"]
["GO:BP","system process","GO:0003008",{"v":2220245189.7723,"d":"2.22E+09"},2293,235,61,18117,"EDNRA,EDNRB,EGFR,ABCC1,ACE,AGER,MGLL,APOE,APP,SCN9A,SCNN1B,SERPINF1,NOTCH1,NR1H3,OLR1,P2RX1,P2RX7,PDE2A,PIK3CG,C5AR1,GJA1,HGF,SLC7A2,SLIT2,CALCRL,CAMK4,PJA2,SNCA,PPARA,PPARG,STK39,PRCP,PRKCA,PRKCZ,PTAFR,PTGS1,PTGS2,HMOX1,HYAL2,ICAM1,IGF1,JAK2,JAM3,KIT,LDLR,LPCAT3,LRRK2,LXN,RARRES2,TLR2,TLR4,CCR2,CDH5,TNFRSF1B,TRPV4,CEBPB,CNR2,CSRP3,CTNNBIP1,CTSC,DICER1"]
["GO:BP","positive regulation of macromolecule biosynthetic process","GO:0010557",{"v":222631952.870422,"d":"2.23E+08"},1851,235,53,18117,"MECOM,EGFR,ELF3,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,ASH1L,ATM,HGF,SLC11A1,CAMK4,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKCQ,PRKD1,PTAFR,NFKB1,NFKBIA,HMGB1,HMGB2,HYAL2,IGF1,IL18,IL33,JAK2,KPNA6,LRRK2,MAPK14,RBPJ,REL,TGFB1,THBS1,TLR2,TLR4,CCL5,CD28,CD81,TNIP1,CEBPB,CIITA,CSRP3,DHX9,CX3CL1,DDX3X"]
["GO:BP","regulation of microglial cell activation","GO:1903978",{"v":223022732.136906,"d":"2.23E+08"},25,235,7,18117,"ATM,GRN,STAP1,LDLR,LRRK2,CTSC,CX3CL1"]
["GO:BP","cellular response to growth factor stimulus","GO:0071363",{"v":243697306.439208,"d":"2.44E+08"},731,235,30,18117,"EGFR,ADAM17,ADAMTS12,APP,APPL2,NOTCH1,NOTCH2,PDCD4,PDE2A,FGFR1,GSTP1,HGF,SLIT2,SNCA,PPARA,PPARG,STAT5B,PRKCZ,PRKD1,NDST1,HYAL2,ITGB6,MAPK14,MAPKAPK2,RBPJ,TGFB1,THBS1,CCL5,CDH5,TNFRSF1B"]
["GO:BP","macromolecule modification","GO:0043412",{"v":244113423.601256,"d":"2.44E+08"},4257,235,93,18117,"MECOM,EDNRB,EGFR,EIF2AK1,EPHA2,ABHD12,ABR,ACE,ADAM17,AGER,MFHAS1,APOE,APP,RPS6KA5,NUPR1,ASH1L,ATM,AXL,PARP4,PDCD4,PIK3CG,BCL6,BCR,C5AR1,FABP4,FGFR1,FN1,FPR1,GPRC5B,GSTP1,HCK,HDAC9,HGF,C3,SIRPA,SLC11A1,SLIT2,CAMK1D,CAMK4,PJA2,SNCA,SOCS3,STAP1,STAT3,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKBIA,HMGB1,HYAL2,ICAM1,IGF1,IL18,IL33,IRAK2,JAK2,KIT,LRRK2,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RICTOR,TGFB1,TGM2,THBS1,TIMP1,TLR2,TLR4,CCL5,CD300A,CD81,CDH5,CDK19,TNFAIP3,TNIP1,ULK4,CIITA,CSF1,CSF1R,CX3CL1,CXCL17,CYLD,DDX3X"]
["GO:BP","regulatory T cell differentiation","GO:0045066",{"v":2479960218.01534,"d":"2.48E+09"},38,235,8,18117,"BCL6,FANCA,FANCD2,IL2RA,LGALS9,TGFB1,CD28,DROSHA"]
["GO:BP","organic substance biosynthetic process","GO:1901576",{"v":2574652475.62865,"d":"2.57E+09"},6248,235,122,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,ABCD1,ACER3,AGER,AIM2,AK7,AKNA,ALOX5,ALOX5AP,MGLL,APOE,APP,SDC1,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,PIK3CG,BCL6,SGMS1,C5AR1,FABP4,FANCA,FANCD2,GJA1,GPX4,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SLC11A1,CAMK1D,CAMK4,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS1,PTGS2,PTPN2,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LDLR,LGALS9,LPCAT3,LPL,LRRK2,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CERS6,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DAGLB,DDX3X"]
["GO:BP","interferon-beta production","GO:0032608",{"v":283754197.551315,"d":"2.84E+08"},54,235,9,18117,"SIRPA,HMGB1,HMGB2,REL,RELB,TLR2,TLR4,DHX9,DDX3X"]
["GO:BP","regulation of lipid metabolic process","GO:0019216",{"v":300739214.029651,"d":"3.01E+08"},419,235,22,18117,"ABCD1,APOE,APPL2,RORA,NR1H3,PIK3CG,C3,SNCA,PPARA,PPARD,PPARG,STAT5B,PRKD1,PTGS2,NFKB1,KIT,LDLR,LPCAT3,LYN,RARRES2,CD81,DAGLB"]
["GO:BP","defense response to bacterium","GO:0042742",{"v":313395523.697725,"d":"3.13E+08"},349,235,20,18117,"EPHA2,ADAM17,SERPINE1,RPS19,NOTCH2,C5AR1,FCER1G,GRN,HAVCR2,SLC11A1,SPN,STAB1,PRKD1,HMGB2,RARRES2,RBPJ,TLR2,TLR4,CEBPB,DROSHA"]
["GO:BP","positive regulation of cellular extravasation","GO:0002693",{"v":316998858.193197,"d":"3.17E+08"},16,235,6,18117,"AGER,PTAFR,ICAM1,IL1R1,JAM3,CCR2"]
["GO:BP","positive regulation of T-helper 1 type immune response","GO:0002827",{"v":316998858.193197,"d":"3.17E+08"},16,235,6,18117,"SLC11A1,PLA2G4A,IL18,IL18R1,IL1R1,CCR2"]
["GO:BP","response to corticosteroid","GO:0031960",{"v":3258395919.42924,"d":"3.26E+09"},165,235,14,18117,"EGFR,SCNN1B,SDC1,SERPINF1,NOTCH1,GSTP1,SLIT2,PTAFR,PTGS2,HMGB1,HSPD1,ICAM1,TGFB1,CYBB"]
["GO:BP","negative regulation of cell migration","GO:0030336",{"v":3760034061.51148,"d":"3.76E+09"},353,235,20,18117,"APOE,SERPINE1,SERPINF1,NOTCH1,GJA1,GSTP1,SLIT2,PPARD,PPARG,STAP1,STAT3,HMGB1,HMOX1,HYAL2,IL33,THBS1,TIMP1,CD200,CD300A,CX3CL1"]
["GO:BP","regulation of T cell mediated immunity","GO:0002709",{"v":380290513.420179,"d":"3.80E+08"},74,235,10,18117,"AGER,PRKCZ,HMGB1,HSPD1,IL18,IL18R1,IL1R1,CCR2,CD81,TNFRSF1B"]
["GO:BP","regulation of lipid storage","GO:0010883",{"v":3902412509.88211,"d":"3.90E+09"},56,235,9,18117,"NR1H3,C3,PPARA,PPARD,PPARG,PTPN2,NFKB1,NFKBIA,LPL"]
["GO:BP","positive regulation of toll-like receptor signaling pathway","GO:0034123",{"v":3941005799.96417,"d":"3.94E+09"},27,235,7,18117,"MFHAS1,NR1H3,PJA2,HMGB1,TLR1,TLR2,DDX3X"]
["GO:BP","regulation of cell development","GO:0060284",{"v":4045568331.27109,"d":"4.05E+09"},502,235,24,18117,"EDNRB,APPL2,SERPINF1,RPS19,NOTCH1,NOTCH2,FN1,GRN,HDAC9,SLIT2,PPARG,HMGB2,IGF1,KIT,LDLR,LRRK2,LYN,TGFB1,TLR2,CDH5,TNFRSF1B,UNC13D,DICER1,CX3CL1"]
["GO:BP","glial cell differentiation","GO:0010001",{"v":4076105683.18629,"d":"4.08E+09"},225,235,16,18117,"EGFR,AGER,APP,NOTCH1,C5AR1,GRN,GSTP1,PPARG,STAT3,LDLR,LYN,TGFB1,TLR2,TLR4,TNFRSF1B,DICER1"]
["GO:BP","positive regulation of response to cytokine stimulus","GO:0060760",{"v":4553458684.48098,"d":"4.55E+09"},57,235,9,18117,"ADAM17,AXL,CASP4,IL1R1,TLR2,TLR4,ZBP1,CSF1,DHX9"]
["GO:BP","positive regulation of cellular catabolic process","GO:0031331",{"v":458002139.189813,"d":"4.58E+08"},393,235,21,18117,"ABCD1,APOE,APP,NUPR1,P2RX7,ATM,SNCA,PPARA,PRKD1,HMGB1,HMOX1,IGF1,IL33,LDLR,LRRK2,CD81,TNFAIP3,TNFRSF1B,VPS35,CTSC,DAGLB"]
["GO:BP","lysosome localization","GO:0032418",{"v":48855523.2159881,"d":"4.89E+07"},76,235,10,18117,"PIK3CG,SNAP23,PTGDR,HMOX1,KIT,LGALS9,LYN,RASGRP1,CD300A,UNC13D"]
["GO:BP","regulation of protein kinase B signaling","GO:0051896",{"v":491189910.878291,"d":"4.91E+08"},259,235,17,18117,"EGFR,EPHA2,MFHAS1,AXL,PIK3AP1,PIK3CG,F3,FGFR1,HGF,PPARA,HYAL2,IL18,KIT,RICTOR,THBS1,CD28,CX3CL1"]
["GO:BP","positive regulation of interleukin-8 production","GO:0032757",{"v":529621269.895276,"d":"5.30E+08"},58,235,9,18117,"SERPINE1,F3,STAT3,HMGB1,HYAL2,LGALS9,TLR1,TLR2,TLR4"]
["GO:BP","animal organ regeneration","GO:0031100",{"v":552558213.64332,"d":"5.53E+08"},77,235,10,18117,"EGFR,NOTCH1,AXL,C5AR1,GSTP1,HGF,PPARG,HMOX1,TGFB1,CEBPB"]
["GO:BP","osteoclast differentiation","GO:0030316",{"v":555840584.871566,"d":"5.56E+08"},98,235,11,18117,"EPHA2,NOTCH2,CAMK4,MAPK14,TCIRG1,TGFB1,TLR4,CD81,CEBPB,CSF1,CSF1R"]
["GO:BP","regulation of apoptotic signaling pathway","GO:2001233",{"v":583288469.057606,"d":"5.83E+08"},363,235,20,18117,"SERPINE1,NUPR1,SGMS1,FGFR1,GSTP1,HGF,PTGS2,PTPN2,HMGB2,HMOX1,HYAL2,ICAM1,IGF1,LRRK2,THBS1,TNFAIP3,CTSC,CX3CL1,CYLD,DDX3X"]
["GO:BP","regulation of cellular component biogenesis","GO:0044087",{"v":608053027.155289,"d":"6.08E+08"},990,235,35,18117,"EPHA2,ACE,APOE,APP,SDC1,NOTCH1,NUPR1,P2RX7,ATM,GBP5,GJA1,HCK,SLIT2,SNCA,STAP1,PRKCA,PRKCZ,HMGB1,ICAM1,IL1RAP,JAM3,KIT,LRFN5,LRRK2,RICTOR,THBS1,TLR2,TLR4,CD47,CDH5,VPS35,CTNNBIP1,CX3CL1,CYLD,DDX3X"]
["GO:BP","glial cell development","GO:0021782",{"v":608053027.155289,"d":"6.08E+08"},122,235,12,18117,"EGFR,AGER,APP,C5AR1,GRN,GSTP1,LDLR,LYN,TGFB1,TLR2,TLR4,DICER1"]
["GO:BP","positive regulation of blood vessel endothelial cell migration","GO:0043536",{"v":62183816.9250911,"d":"6.22E+07"},78,235,10,18117,"ADAM17,FGFR1,HDAC9,STAT5A,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,THBS1"]
["GO:BP","negative regulation of locomotion","GO:0040013",{"v":635185412.10756,"d":"6.35E+08"},401,235,21,18117,"APOE,SERPINE1,SERPINF1,NOTCH1,GJA1,GSTP1,SLIT2,PPARD,PPARG,STAP1,STAT3,PTPN2,HMGB1,HMOX1,HYAL2,IL33,THBS1,TIMP1,CD200,CD300A,CX3CL1"]
["GO:BP","negative regulation of interferon-gamma production","GO:0032689",{"v":666525508.931414,"d":"6.67E+08"},43,235,8,18117,"AXL,HAVCR2,HMGB1,IL1RL1,IL33,LGALS9,TLR4,CD96"]
["GO:BP","positive regulation of pattern recognition receptor signaling pathway","GO:0062208",{"v":666525508.931414,"d":"6.67E+08"},43,235,8,18117,"MFHAS1,NR1H3,PJA2,HMGB1,TLR1,TLR2,TLR4,DDX3X"]
["GO:BP","negative regulation of response to biotic stimulus","GO:0002832",{"v":678370812.289891,"d":"6.78E+08"},100,235,11,18117,"SERPINB9,RPS19,NR1H3,GRN,HAVCR2,PPARG,PTPN2,IL2RA,LGALS9,CD96,TNFAIP3"]
["GO:BP","fatty acid metabolic process","GO:0006631",{"v":716189924.878038,"d":"7.16E+08"},404,235,21,18117,"ABCD1,ALOX5,ALOX5AP,MGLL,APPL2,AOAH,NR1H3,GPX4,GSTP1,C3,PLA2G4A,SNCA,PPARA,PPARD,PPARG,PTGIS,PTGS1,PTGS2,LPL,MAPK14,DAGLB"]
["GO:BP","reproductive process","GO:0022414",{"v":718352749.539945,"d":"7.18E+08"},1493,235,45,18117,"EDNRB,EGFR,ACE,APP,SDC1,SERPINF1,NOTCH1,NOTCH2,NUPR1,P2RX1,ASH1L,ATM,AXL,BCL6,FANCA,FANCD2,GJA1,GPX4,HAVCR2,C3,SLIT2,PPARD,PPARG,SOCS3,STAT3,STAT5B,PTAFR,PTGFR,PTGS2,HMGB2,ICAM1,IDO1,IGF1,JAM3,KIT,KPNA6,LGALS9,LRRK2,MAPK14,RBPJ,TGFB1,TIMP1,CEBPB,CSF1,DDX3X"]
["GO:BP","negative regulation of cell motility","GO:2000146",{"v":750847450.148446,"d":"7.51E+08"},369,235,20,18117,"APOE,SERPINE1,SERPINF1,NOTCH1,GJA1,GSTP1,SLIT2,PPARD,PPARG,STAP1,STAT3,HMGB1,HMOX1,HYAL2,IL33,THBS1,TIMP1,CD200,CD300A,CX3CL1"]
["GO:BP","reproduction","GO:0000003",{"v":759255257.196886,"d":"7.59E+08"},1496,235,45,18117,"EDNRB,EGFR,ACE,APP,SDC1,SERPINF1,NOTCH1,NOTCH2,NUPR1,P2RX1,ASH1L,ATM,AXL,BCL6,FANCA,FANCD2,GJA1,GPX4,HAVCR2,C3,SLIT2,PPARD,PPARG,SOCS3,STAT3,STAT5B,PTAFR,PTGFR,PTGS2,HMGB2,ICAM1,IDO1,IGF1,JAM3,KIT,KPNA6,LGALS9,LRRK2,MAPK14,RBPJ,TGFB1,TIMP1,CEBPB,CSF1,DDX3X"]
["GO:BP","cellular response to amyloid-beta","GO:1904646",{"v":798227522.215998,"d":"7.98E+08"},44,235,8,18117,"ABCC1,AGER,APP,GJA1,CASP4,ICAM1,IGF1,TLR4"]
["GO:BP","tissue homeostasis","GO:0001894",{"v":874690390.444164,"d":"8.75E+08"},270,235,17,18117,"EGFR,NOTCH1,P2RX7,GJA1,STK39,PRKCA,PTGS2,ITGB6,JAM3,LIPA,TCIRG1,TGFB1,TLR4,CDH5,TNFAIP3,CSF1,CSF1R"]
["GO:BP","regulation of activated T cell proliferation","GO:0046006",{"v":955667108.774414,"d":"9.56E+08"},45,235,8,18117,"AGER,STAT5B,HMGB1,IDO1,IGF1,IL18,IL2RA,LGALS9"]
["GO:BP","regulation of leukocyte degranulation","GO:0043300",{"v":955667108.774414,"d":"9.56E+08"},45,235,8,18117,"PTAFR,HMOX1,ITGAM,LGALS9,LYN,CCR2,CD300A,UNC13D"]
["GO:BP","tissue development","GO:0009888",{"v":981546306.56258,"d":"9.82E+08"},2107,235,56,18117,"EDNRA,EDNRB,EGFR,ELF3,EPHA2,ADAM17,ADAMTS12,AKNA,ALOX5,SDC1,SERPINE1,NOTCH1,NOTCH2,NUPR1,P2RX7,ASH1L,ATM,ATRN,PDCD4,PDE2A,BCR,FGFR1,FN1,GJA1,HCK,HDAC9,HGF,C3,SLIT2,PPARA,PPARD,PPARG,SOCS3,STAT5B,PSMA1,PTGS2,HYAL2,ICAM1,IGF1,ITGAM,ITGB6,JAK2,MAPK14,RBPJ,TCIRG1,TGFB1,TGM2,TIMP1,CD81,CDH5,TRPV4,CEBPB,CSF1,CSF1R,CSRP3,CTNNBIP1"]
["GO:BP","cellular response to peptide hormone stimulus","GO:0071375",{"v":986242257.633901,"d":"9.86E+08"},340,235,19,18117,"APPL2,GSTP1,HDAC9,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PTPN2,NFKB1,JAK2,LPL,LYN,RARRES2,TCIRG1,TGFB1,CSRP3"]
["GO:BP","chronic inflammatory response","GO:0002544",{"v":986242257.633901,"d":"9.86E+08"},19,235,6,18117,"GJA1,IDO1,THBS1,CCL5,TNFAIP3,UNC13D"]
["GO:BP","positive regulation of neuroinflammatory response","GO:0150078",{"v":986242257.633901,"d":"9.86E+08"},19,235,6,18117,"NUPR1,STAP1,IL18,IL33,LRRK2,CTSC"]
["GO:BP","positive regulation of lymphocyte mediated immunity","GO:0002708","0.0000010008496515299614",104,235,11,18117,"C3,STAT5B,PRKCZ,HSPD1,IL18,IL18R1,IL18RAP,IL1R1,RASGRP1,CD28,CD81"]
["GO:BP","positive regulation of nucleic acid-templated transcription","GO:1903508","0.0000010113560143321695",1617,235,47,18117,"MECOM,EGFR,ELF3,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,ASH1L,ATM,HGF,SLC11A1,CAMK4,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKD1,NFKB1,NFKBIA,HMGB1,HMGB2,HYAL2,IGF1,IL18,IL33,KPNA6,MAPK14,RBPJ,REL,TGFB1,TLR2,TLR4,CD28,CD81,TNIP1,CEBPB,CIITA,CSRP3,DHX9,CX3CL1,DDX3X"]
["GO:BP","positive regulation of transcription, DNA-templated","GO:0045893","0.0000010113560143321695",1617,235,47,18117,"MECOM,EGFR,ELF3,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,ASH1L,ATM,HGF,SLC11A1,CAMK4,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKD1,NFKB1,NFKBIA,HMGB1,HMGB2,HYAL2,IGF1,IL18,IL33,KPNA6,MAPK14,RBPJ,REL,TGFB1,TLR2,TLR4,CD28,CD81,TNIP1,CEBPB,CIITA,CSRP3,DHX9,CX3CL1,DDX3X"]
["GO:BP","positive regulation of RNA biosynthetic process","GO:1902680","0.000001028616010554115",1618,235,47,18117,"MECOM,EGFR,ELF3,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,ASH1L,ATM,HGF,SLC11A1,CAMK4,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKD1,NFKB1,NFKBIA,HMGB1,HMGB2,HYAL2,IGF1,IL18,IL33,KPNA6,MAPK14,RBPJ,REL,TGFB1,TLR2,TLR4,CD28,CD81,TNIP1,CEBPB,CIITA,CSRP3,DHX9,CX3CL1,DDX3X"]
["GO:BP","negative regulation of cellular component movement","GO:0051271","0.000001041700359848932",377,235,20,18117,"APOE,SERPINE1,SERPINF1,NOTCH1,GJA1,GSTP1,SLIT2,PPARD,PPARG,STAP1,STAT3,HMGB1,HMOX1,HYAL2,IL33,THBS1,TIMP1,CD200,CD300A,CX3CL1"]
["GO:BP","regulation of type 2 immune response","GO:0002828","0.0000010581323431078197",31,235,7,18117,"BCL6,PRKCZ,IDO1,IL18,IL33,CCR2,CD81"]
["GO:BP","positive regulation of lipid metabolic process","GO:0045834","0.0000010965347247673631",155,235,13,18117,"ABCD1,APOE,NR1H3,PPARA,PPARD,PPARG,PRKD1,PTGS2,KIT,LDLR,LYN,CD81,DAGLB"]
["GO:BP","vasoconstriction","GO:0042310","0.0000010965347247673631",83,235,10,18117,"EDNRA,EDNRB,EGFR,ACE,SCNN1B,P2RX1,GJA1,PTAFR,PTGS2,ICAM1"]
["GO:BP","positive regulation of protein kinase B signaling","GO:0051897","0.0000012002677879333555",184,235,14,18117,"EGFR,MFHAS1,AXL,PIK3AP1,PIK3CG,F3,FGFR1,HGF,IL18,KIT,RICTOR,THBS1,CD28,CX3CL1"]
["GO:BP","positive regulation of reactive oxygen species metabolic process","GO:2000379","0.0000013257720954366217",107,235,11,18117,"EGFR,GSTP1,SNCA,PTGS2,ICAM1,ITGAM,JAK2,MAPK14,THBS1,TLR4,DUOXA1"]
["GO:BP","negative regulation of lymphocyte proliferation","GO:0050672","0.0000013693188799375549",85,235,10,18117,"ATM,HAVCR2,SPN,IDO1,IL2RA,LGALS9,LYN,TGFB1,CD300A,CEBPB"]
["GO:BP","positive regulation of monocyte chemotaxis","GO:0090026","0.0000013693188799375549",20,235,6,18117,"SERPINE1,PLA2G7,HMGB1,CCL5,CCR2,CXCL17"]
["GO:BP","peptidyl-serine phosphorylation","GO:0018105","0.0000013819796451751982",313,235,18,18117,"EGFR,APP,RPS6KA5,ATM,HGF,CAMK1D,CAMK4,SNCA,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGS2,LRRK2,MAPK14,MAPKAPK2,RICTOR"]
["GO:BP","natural killer cell mediated immunity","GO:0002228","0.000001391281509474347",65,235,9,18117,"SERPINB9,HAVCR2,STAT5B,IL18,IL18RAP,LGALS9,RASGRP1,CD96,UNC13D"]
["GO:BP","negative regulation of extrinsic apoptotic signaling pathway","GO:2001237","0.0000014486727408866715",108,235,11,18117,"SERPINE1,GSTP1,HGF,HMGB2,HMOX1,ICAM1,IGF1,THBS1,TNFAIP3,CX3CL1,DDX3X"]
["GO:BP","positive regulation of endopeptidase activity","GO:0010950","0.0000014515111005691193",187,235,14,18117,"AGER,AIM2,P2RX1,F3,SNCA,PPARG,STAT3,HMGB1,HSPD1,JAK2,LGALS9,LYN,UACA,DDX3X"]
["GO:BP","negative regulation of mononuclear cell proliferation","GO:0032945","0.000001520790905655195",86,235,10,18117,"ATM,HAVCR2,SPN,IDO1,IL2RA,LGALS9,LYN,TGFB1,CD300A,CEBPB"]
["GO:BP","macrophage differentiation","GO:0030225","0.0000015643694429997751",48,235,8,18117,"EIF2AK1,APP,PRKCA,PTPN2,TGFB1,TLR2,CSF1,CSF1R"]
["GO:BP","response to mechanical stimulus","GO:0009612","0.0000015643694429997751",218,235,15,18117,"EGFR,ABHD12,PDE2A,GJA1,PPARG,PTGS2,NFKB1,NFKBIA,KIT,MAPK14,TGFB1,THBS1,TLR4,TRPV4,CSRP3"]
["GO:BP","positive regulation of catabolic process","GO:0009896","0.000001641783281177116",464,235,22,18117,"ABCD1,APOE,APP,NUPR1,P2RX7,ATM,GJA1,SNCA,PPARA,PRKD1,HMGB1,HMOX1,IGF1,IL33,LDLR,LRRK2,CD81,TNFAIP3,TNFRSF1B,VPS35,CTSC,DAGLB"]
["GO:BP","regulation of T cell cytokine production","GO:0002724","0.000001644638502532651",33,235,7,18117,"PRKCZ,IL18,IL18R1,IL1R1,CCR2,CD81,TNFRSF1B"]
["GO:BP","positive regulation of anion transport","GO:1903793","0.0000016791768123184593",504,235,23,18117,"EGFR,APOE,NR1H3,GJA1,C3,PLA2G4A,PPARD,PRKCZ,PRKD1,PTAFR,PTGS2,NFKBIA,HYAL2,IGF1,ITGAM,JAK2,LPCAT3,MAPK14,TLR2,TLR4,CD81,CEBPB,DHX9"]
["GO:BP","regulation of tyrosine phosphorylation of STAT protein","GO:0042509","0.0000016841016978454829",87,235,10,18117,"SOCS3,STAT3,PTPN2,IGF1,IL18,JAK2,KIT,LYN,CCL5,CSF1R"]
["GO:BP","viral life cycle","GO:0019058","0.0000017030699579638037",353,235,19,18117,"EGFR,EPHA2,APOE,NOTCH1,AXL,SLAMF1,PPARA,HYAL2,ICAM1,ITGB6,KPNA6,LDLR,LGALS9,CCL5,CD28,CD81,TNIP1,CIITA,DDX3X"]
["GO:BP","small molecule metabolic process","GO:0044281","0.0000017290407335546037",1921,235,52,18117,"ENPP3,EPHA2,ABCC1,ABCD1,ACER3,AK7,ALDH2,ALOX5,ALOX5AP,MGLL,APOE,APP,APPL2,AOAH,RORA,NR1H3,NUPR1,P2RX7,PDE2A,PDE5A,GPX4,GSTP1,C3,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PSMA1,PTAFR,PTGIS,PTGS1,PTGS2,PTPN2,NFKB1,HMGB1,IDO1,IGF1,KIT,LDLR,LPCAT3,LPL,LRRK2,MAPK14,MAPKAPK2,TLR2,DAGLB,HK1"]
["GO:BP","negative regulation of MAPK cascade","GO:0043409","0.0000017411330863284253",190,235,14,18117,"MECOM,APOE,P2RX7,ASH1L,PDCD4,GSTP1,SIRPA,PTPN2,HYAL2,LYN,TLR4,CD300A,TNIP1,CYLD"]
["GO:BP","multi-organism process","GO:0051704","0.0000017729684796043958",1135,235,37,18117,"EDNRB,ACE,APP,NOTCH1,P2RX1,ASH1L,ATM,AXL,BCL6,FANCA,FANCD2,GJA1,GPX4,HAVCR2,PPARD,STAT3,STAT5B,PRKCA,PTAFR,PTGFR,PTGS2,HMGB2,HYAL2,IDO1,IGF1,JAM3,KIT,KPNA6,LGALS9,LRRK2,LY86,LY96,TGFB1,TIMP1,TNFAIP3,CX3CL1,DDX3X"]
["GO:BP","positive regulation of phagocytosis","GO:0050766","0.0000017749573875115277",67,235,9,18117,"APPL2,FCER1G,C3,SIRPA,SLC11A1,CAMK1D,PPARG,STAP1,CD47"]
["GO:BP","regulation of CD4-positive, alpha-beta T cell activation","GO:2000514","0.0000017749573875115277",67,235,9,18117,"AGER,BCL6,PRKCQ,PRKCZ,NFKBID,HMGB1,IL18,LGALS9,CD81"]
["GO:BP","T cell migration","GO:0072678","0.0000017749573875115277",67,235,9,18117,"ADAM17,APP,PIK3CG,SPN,STK39,ICAM1,CCL5,CCR2,CD200"]
["GO:BP","positive regulation of fat cell differentiation","GO:0045600","0.0000017749573875115277",67,235,9,18117,"METRNL,PPARD,PPARG,PTGS2,LPL,MAPK14,RARRES2,CEBPB,CMKLR1"]
["GO:BP","activated T cell proliferation","GO:0050798","0.0000018130764369694922",49,235,8,18117,"AGER,STAT5B,HMGB1,IDO1,IGF1,IL18,IL2RA,LGALS9"]
["GO:BP","regulation of transcription by RNA polymerase II","GO:0006357","0.000001817155478266223",2555,235,63,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,ASH1L,ATM,PDE2A,BCL6,HDAC9,HGF,SLC11A1,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKD1,PSMA1,PTAFR,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,IGF1,IL18,IL33,KIT,KPNA6,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD28,CD81,TNIP1,TRPV4,CEBPB,CIITA,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,DDX3X"]
["GO:BP","nitric-oxide synthase biosynthetic process","GO:0051767","0.0000018306630488310553",21,235,6,18117,"GSTP1,IL33,JAK2,LRRK2,TLR2,TLR4"]
["GO:BP","myeloid dendritic cell differentiation","GO:0043011","0.0000018306630488310553",21,235,6,18117,"NOTCH2,CAMK4,ITGB6,RBPJ,RELB,TGFB1"]
["GO:BP","regulation of nitric-oxide synthase biosynthetic process","GO:0051769","0.0000018306630488310553",21,235,6,18117,"GSTP1,IL33,JAK2,LRRK2,TLR2,TLR4"]
["GO:BP","ensheathment of neurons","GO:0007272","0.000002022405493673081",137,235,12,18117,"ABCD1,ACER3,ATRN,HGF,PMP22,PPARD,JAM3,TGFB1,TLR2,TNFRSF1B,CTSC,DICER1"]
["GO:BP","axon ensheathment","GO:0008366","0.000002022405493673081",137,235,12,18117,"ABCD1,ACER3,ATRN,HGF,PMP22,PPARD,JAM3,TGFB1,TLR2,TNFRSF1B,CTSC,DICER1"]
["GO:BP","cellular response to external stimulus","GO:0071496","0.0000020278822670120413",322,235,18,18117,"EGFR,AXL,PDE2A,GJA1,GSTP1,PPARA,PPARG,PRKD1,PTGS2,NFKB1,HMOX1,ICAM1,LPL,LRRK2,LYN,TGFB1,TLR4,CD68"]
["GO:BP","tyrosine phosphorylation of STAT protein","GO:0007260","0.000002042019716316415",89,235,10,18117,"SOCS3,STAT3,PTPN2,IGF1,IL18,JAK2,KIT,LYN,CCL5,CSF1R"]
["GO:BP","regulation of blood pressure","GO:0008217","0.0000020663914078342238",193,235,14,18117,"EDNRA,EDNRB,ACE,P2RX1,GJA1,PPARA,PPARG,STK39,PRCP,PTAFR,PTGS1,PTGS2,HMOX1,RARRES2"]
["GO:BP","positive regulation of RNA metabolic process","GO:0051254","0.0000020750981934055623",1714,235,48,18117,"MECOM,EGFR,ELF3,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,ASH1L,ATM,HGF,SLC11A1,CAMK4,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKD1,NFKB1,NFKBIA,HMGB1,HMGB2,HYAL2,IGF1,IL18,IL33,KPNA6,MAPK14,RBPJ,REL,TGFB1,TLR2,TLR4,CD28,CD81,TNFRSF1B,TNIP1,CEBPB,CIITA,CSRP3,DHX9,CX3CL1,DDX3X"]
["GO:BP","response to extracellular stimulus","GO:0009991","0.0000021499190002965694",512,235,23,18117,"EGFR,EIF2AK1,APOE,APPL2,RPS19,AXL,GSTP1,PPARA,PPARD,PPARG,PRKD1,PTGS2,HMOX1,ICAM1,LDLR,LPL,LRRK2,LYN,RARRES2,TGFB1,CD68,TRPV4,CYBB"]
["GO:BP","immune response-regulating cell surface receptor signaling pathway","GO:0002768","0.0000021499190002965694",512,235,23,18117,"APPL2,MS4A2,RPS6KA5,C5AR1,FCER1G,FPR1,FPR3,HCK,STAP1,PRKCQ,PSMA1,PTPN2,NFKB1,NFKBID,KIT,LYN,RELB,THEMIS2,CD28,CD300A,CD47,CD81,CMKLR1"]
["GO:BP","positive regulation of endothelial cell migration","GO:0010595","0.000002168257817763723",138,235,12,18117,"ADAM17,PIK3CG,FGFR1,GRN,HDAC9,STAT5A,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,THBS1"]
["GO:BP","alpha-beta T cell differentiation","GO:0046632","0.0000022025250308252143",113,235,11,18117,"RORA,BCL6,SPN,STAT3,PRKCZ,NFKBID,HMGB1,IL18,IL18R1,LGALS9,RELB"]
["GO:BP","positive regulation of endothelial cell proliferation","GO:0001938","0.0000022025250308252143",113,235,11,18117,"ADAM17,F3,FGFR1,STAT3,STAT5A,PRKCA,PRKD1,HMGB1,HMGB2,HMOX1,RICTOR"]
["GO:BP","negative regulation of mast cell activation","GO:0033004","0.0000022607267266998783",12,235,5,18117,"ENPP3,HMOX1,LGALS9,CD300A,CNR2"]
["GO:BP","regulation of fat cell differentiation","GO:0045598","0.0000023330541127922356",139,235,12,18117,"ALOX5,METRNL,RORA,PPARD,PPARG,PTGS2,LPL,MAPK14,RARRES2,TRPV4,CEBPB,CMKLR1"]
["GO:BP","immune response-regulating signaling pathway","GO:0002764","0.0000023631122638078598",515,235,23,18117,"APPL2,MS4A2,RPS6KA5,C5AR1,FCER1G,FPR1,FPR3,HCK,STAP1,PRKCQ,PSMA1,PTPN2,NFKB1,NFKBID,KIT,LYN,RELB,THEMIS2,CD28,CD300A,CD47,CD81,CMKLR1"]
["GO:BP","respiratory burst","GO:0045730","0.000002425861805631278",35,235,7,18117,"RPS19,PIK3CG,GRN,HCK,SLC11A1,CAMK1D,CYBB"]
["GO:BP","negative regulation of leukocyte mediated immunity","GO:0002704","0.0000024308369736854803",51,235,8,18117,"SERPINB9,BCL6,HAVCR2,HMOX1,LGALS9,CCR2,CD300A,CD96"]
["GO:BP","negative regulation of lipid storage","GO:0010888","0.0000024308369736854803",22,235,6,18117,"NR1H3,PPARA,PPARD,PPARG,PTPN2,NFKBIA"]
["GO:BP","lipid homeostasis","GO:0055088","0.000002450450685995191",167,235,13,18117,"ABCD1,APOE,RORA,NR1H3,FABP4,HDAC9,PPARG,IL18,ITGB6,LDLR,LPL,TGFB1,DDX3X"]
["GO:BP","proteolysis","GO:0006508","0.000002526790740471876",1836,235,50,18117,"ACE,ADAM17,ADAMTS12,AGER,AIM2,APOE,APP,SERPINB9,SERPINE1,SERPINF1,NR1H3,NUPR1,OLR1,P2RX1,F3,FN1,GRN,HGF,C3,CASP4,SNCA,PPARG,STAT3,PRCP,PRKCQ,PSMA1,PTGS2,NFKB1,NFKBIA,HMGB1,HSPD1,IL1R2,IL33,JAK2,LGALS9,LPCAT3,LRRK2,LXN,LYN,THBS1,TIMP1,TNFAIP3,TNFRSF1B,TNIP1,TPSB2,UACA,CTSC,CTSS,CYLD,DDX3X"]
["GO:BP","regulation of cellular catabolic process","GO:0031329","0.000002573037245301413",866,235,31,18117,"ABCD1,APOE,APP,NUPR1,P2RX7,ATM,PIK3CG,HGF,SLC11A1,SNCA,PPARA,STAT3,PRKCA,PRKD1,PSMA1,HMGB1,HMOX1,IGF1,IL33,LDLR,LRRK2,MAPK14,MAPKAPK2,TIMP1,CD81,TNFAIP3,TNFRSF1B,VPS35,CTSC,DHX9,DAGLB"]
["GO:BP","response to temperature stimulus","GO:0009266","0.0000026472725330490265",228,235,15,18117,"METRNL,APPL2,ATM,PPARG,PTGS2,NFKBIA,HMOX1,HSPD1,IGF1,LPL,LXN,LYN,MAPKAPK2,THBS1,TRPV4"]
["GO:BP","response to insulin","GO:0032868","0.0000028185952424415014",295,235,17,18117,"APPL2,GSTP1,HDAC9,PPARA,PPARG,SOCS3,PRKCQ,PRKCZ,PTPN2,ICAM1,LPL,LYN,RARRES2,TCIRG1,TLR2,TRPV4,CSRP3"]
["GO:BP","B cell activation","GO:0042113","0.000002827605153340736",330,235,18,18117,"ADAM17,NOTCH2,ATM,BCL6,HDAC9,STAT5B,PTPN2,HSPD1,KIT,LYN,RASGRP1,RBPJ,TCIRG1,TLR4,CD28,CD300A,CD81,TNFAIP3"]
["GO:BP","erythrocyte differentiation","GO:0030218","0.000002827605153340736",116,235,11,18117,"MFHAS1,RPS19,BCL6,STAT3,STAT5B,PTPN2,HMGB2,JAK2,KIT,LYN,MAPK14"]
["GO:BP","positive regulation of tyrosine phosphorylation of STAT protein","GO:0042531","0.0000028330792660736317",71,235,9,18117,"SOCS3,STAT3,IGF1,IL18,JAK2,KIT,LYN,CCL5,CSF1R"]
["GO:BP","negative regulation of leukocyte cell-cell adhesion","GO:1903038","0.0000028874221445662203",142,235,12,18117,"BCL6,HAVCR2,PPARA,SPN,PTPN2,HMGB1,IDO1,IL2RA,LGALS9,TGFB1,CD300A,CEBPB"]
["GO:BP","neutral lipid metabolic process","GO:0006638","0.0000028874221445662203",142,235,12,18117,"ABHD12,MGLL,APOE,NR1H3,PIK3CG,FABP4,C3,PLA2G4A,SNCA,LDLR,LPL,DAGLB"]
["GO:BP","regulation of platelet activation","GO:0010543","0.0000029132156328979344",36,235,7,18117,"APOE,FCER1G,PLA2G4A,PRKCA,PRKCQ,LYN,TLR4"]
["GO:BP","response to hypoxia","GO:0001666","0.0000029132156328979344",367,235,19,18117,"EDNRA,ADAM17,AGER,RORA,NOTCH1,ATM,PPARA,PPARD,PSMA1,PTGIS,PTGS2,HMOX1,HSPD1,ICAM1,RBPJ,TGFB1,THBS1,TLR2,CYBB"]
["GO:BP","cell-substrate adhesion","GO:0031589","0.0000029132156328979344",367,235,19,18117,"ABI3BP,ADAMTS12,SERPINE1,NOTCH1,ATRN,AXL,BCL6,BCR,FN1,PPARD,PRKCZ,ITGB6,JAK2,JAM3,THBS1,CD96,UNC13D,CSF1,CX3CL1"]
["GO:BP","T cell cytokine production","GO:0002369","0.0000029132156328979344",36,235,7,18117,"PRKCZ,IL18,IL18R1,IL1R1,CCR2,CD81,TNFRSF1B"]
["GO:BP","lymphocyte migration","GO:0072676","0.0000030507411943669986",117,235,11,18117,"ADAM17,APP,PIK3CG,SPN,STK39,ICAM1,CCL4,CCL5,CCR2,CD200,CX3CL1"]
["GO:BP","negative regulation of neuroinflammatory response","GO:0150079","0.0000031777904543940027",23,235,6,18117,"GRN,IGF1,LDLR,CD200,TNFRSF1B,CX3CL1"]
["GO:BP","negative regulation of macrophage activation","GO:0043031","0.0000031777904543940027",23,235,6,18117,"NR1H3,GRN,LDLR,LRFN5,CD200,CX3CL1"]
["GO:BP","regulation of lipid localization","GO:1905952","0.0000032569704339862277",201,235,14,18117,"APOE,NR1H3,C3,PLA2G4A,SNCA,PPARA,PPARD,PPARG,PTPN2,NFKB1,NFKBIA,LPCAT3,LPL,THBS1"]
["GO:BP","endocytosis","GO:0006897","0.0000033426748389576993",696,235,27,18117,"EGFR,AGER,APOE,APP,APPL2,SERPINE1,NR1H3,OLR1,AXL,PIK3CG,FCER1G,C3,CALCRL,SNCA,PPARG,STAB1,STAP1,PRKD1,ITGAM,LDLR,LRRK2,MAPKAPK2,THBS1,CD163,CD300A,CD6,CD81"]
["GO:BP","response to oxygen levels","GO:0070482","0.000003348507462613547",408,235,20,18117,"EDNRA,ADAM17,AGER,RORA,NOTCH1,ATM,PPARA,PPARD,PPARG,PSMA1,PTGIS,PTGS2,HMOX1,HSPD1,ICAM1,RBPJ,TGFB1,THBS1,TLR2,CYBB"]
["GO:BP","regulation of CD40 signaling pathway","GO:2000348","0.0000034136349292385797",6,235,4,18117,"FANCA,FANCD2,SLAMF1,TNFAIP3"]
["GO:BP","macrophage colony-stimulating factor signaling pathway","GO:0038145","0.0000034136349292385797",6,235,4,18117,"STAP1,PTPN2,CSF1,CSF1R"]
["GO:BP","negative regulation of cell differentiation","GO:0045596","0.0000034193303827760075",697,235,27,18117,"EDNRB,EGFR,ADAMTS12,APP,APPL2,RORA,NOTCH1,NR1H3,PDCD4,BCL6,PPARA,PPARD,PPARG,STAT3,STAT5B,PTPN2,NFKBIA,HMGB1,IGF1,IL18,LDLR,LYN,RBPJ,TGFB1,TLR4,TRPV4,DICER1"]
["GO:BP","type 2 immune response","GO:0042092","0.0000035053609589269157",37,235,7,18117,"BCL6,PRKCZ,IDO1,IL18,IL33,CCR2,CD81"]
["GO:BP","regulation of phospholipase activity","GO:0010517","0.000003523389806036756",73,235,9,18117,"EDNRA,EGFR,C5AR1,FGFR1,SNCA,PRKCZ,PTAFR,KIT,CCL5"]
["GO:BP","cell adhesion mediated by integrin","GO:0033627","0.000003523389806036756",73,235,9,18117,"EPHA2,ADAM17,SERPINE1,PIK3CG,ICAM1,ITGB6,JAM3,LYN,CCL5"]
["GO:BP","peptidyl-serine modification","GO:0018209","0.0000035830851659835703",336,235,18,18117,"EGFR,APP,RPS6KA5,ATM,HGF,CAMK1D,CAMK4,SNCA,STK39,PRKCA,PRKCQ,PRKCZ,PRKD1,PTGS2,LRRK2,MAPK14,MAPKAPK2,RICTOR"]
["GO:BP","positive regulation of cytokine production involved in immune response","GO:0002720","0.000003695486529700914",54,235,8,18117,"GPRC5B,PRKCZ,IL18,IL18R1,IL1R1,TLR4,CD81,HK1"]
["GO:BP","maintenance of location","GO:0051235","0.0000037320416068223758",337,235,18,18117,"APOE,NR1H3,GJA1,C3,SNCA,PPARA,PPARD,PPARG,STAT5B,PRKD1,PTPN2,NFKB1,NFKBIA,LPL,LYN,TGFB1,CX3CL1,HK1"]
["GO:BP","gland morphogenesis","GO:0022612","0.000003865089146809779",120,235,11,18117,"ELF3,EPHA2,NOTCH1,NOTCH2,HGF,TGFB1,TGM2,TNFAIP3,CEBPB,CSF1,CSF1R"]
["GO:BP","glycerolipid catabolic process","GO:0046503","0.000003939845433622334",74,235,9,18117,"ABHD12,MGLL,PIK3CG,FABP4,PLA2G4A,PLA2G7,LDLR,LPL,DAGLB"]
["GO:BP","cellular response to abiotic stimulus","GO:0071214","0.000004046852960126442",339,235,18,18117,"EGFR,ATM,PDE2A,GJA1,STK39,PTAFR,PTGS2,NFKB1,HYAL2,ITGB6,MAPK14,RELB,TGFB1,TIMP1,TLR4,TRPV4,CIITA,DDX3X"]
["GO:BP","cellular response to environmental stimulus","GO:0104004","0.000004046852960126442",339,235,18,18117,"EGFR,ATM,PDE2A,GJA1,STK39,PTAFR,PTGS2,NFKB1,HYAL2,ITGB6,MAPK14,RELB,TGFB1,TIMP1,TLR4,TRPV4,CIITA,DDX3X"]
["GO:BP","olefinic compound metabolic process","GO:0120254","0.000004181159088621036",121,235,11,18117,"ABCD1,ALOX5,MGLL,GPX4,GSTP1,PLA2G4A,STAT5B,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","positive regulation of lymphocyte migration","GO:2000403","0.000004187502234180176",38,235,7,18117,"ADAM17,APP,SPN,STK39,CCL4,CCL5,CCR2"]
["GO:BP","response to amyloid-beta","GO:1904645","0.000004231041959250168",55,235,8,18117,"ABCC1,AGER,APP,GJA1,CASP4,ICAM1,IGF1,TLR4"]
["GO:BP","regulation of catabolic process","GO:0009894","0.0000043606477101226985",1033,235,34,18117,"EGFR,ABCD1,APOE,APP,NUPR1,P2RX7,ATM,PIK3CG,GJA1,HGF,SLC11A1,SNCA,PPARA,STAT3,PRKCA,PRKD1,PSMA1,HMGB1,HMOX1,IGF1,IL33,LDLR,LRRK2,MAPK14,MAPKAPK2,RARRES2,TIMP1,CD81,TNFAIP3,TNFRSF1B,VPS35,CTSC,DHX9,DAGLB"]
["GO:BP","positive regulation of lipase activity","GO:0060193","0.000004385943018216473",75,235,9,18117,"EDNRA,EGFR,NR1H3,C5AR1,FGFR1,PRKCZ,PTAFR,KIT,CCL5"]
["GO:BP","multicellular organismal reproductive process","GO:0048609","0.000004612210513601557",845,235,30,18117,"EDNRB,EGFR,ACE,APP,SERPINF1,NOTCH1,P2RX1,ASH1L,ATM,AXL,BCL6,FANCA,FANCD2,GJA1,GPX4,HAVCR2,SLIT2,PPARD,STAT5B,PTAFR,PTGS2,HMGB2,IGF1,JAM3,KIT,KPNA6,LGALS9,LRRK2,TGFB1,DDX3X"]
["GO:BP","regulation of cysteine-type endopeptidase activity","GO:2000116","0.0000048582794013446",240,235,15,18117,"AIM2,SERPINB9,P2RX1,F3,HGF,SNCA,PPARG,PTGS2,HMGB1,HSPD1,JAK2,LGALS9,THBS1,UACA,DDX3X"]
["GO:BP","negative regulation of T cell activation","GO:0050868","0.000004887880297553528",123,235,11,18117,"BCL6,HAVCR2,SPN,PTPN2,HMGB1,IDO1,IL2RA,LGALS9,TGFB1,CD300A,CEBPB"]
["GO:BP","negative regulation of phosphorylation","GO:0042326","0.000005129055932114538",420,235,20,18117,"APOE,NUPR1,PDCD4,FABP4,GSTP1,HGF,SIRPA,SLIT2,SNCA,PPARA,SOCS3,STAP1,STAT3,PRKCZ,PTPN2,HYAL2,LRRK2,LYN,CD300A,TNFAIP3"]
["GO:BP","organic acid metabolic process","GO:0006082","0.000005135233689895297",1090,235,35,18117,"ABCC1,ABCD1,ALOX5,ALOX5AP,MGLL,APP,APPL2,AOAH,NR1H3,NUPR1,P2RX7,GPX4,GSTP1,C3,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PSMA1,PTGIS,PTGS1,PTGS2,IDO1,IGF1,KIT,LPL,MAPK14,MAPKAPK2,TLR2,DAGLB,HK1"]
["GO:BP","response to decreased oxygen levels","GO:0036293","0.000005139446541623146",382,235,19,18117,"EDNRA,ADAM17,AGER,RORA,NOTCH1,ATM,PPARA,PPARD,PSMA1,PTGIS,PTGS2,HMOX1,HSPD1,ICAM1,RBPJ,TGFB1,THBS1,TLR2,CYBB"]
["GO:BP","organophosphate metabolic process","GO:0019637","0.0000051453206111218",1041,235,34,18117,"ENPP3,EPHA2,ABCD1,ABHD12,AK7,APP,RORA,NR1H3,NUPR1,P2RX7,ATM,PDE2A,PDE5A,PIK3CG,SGMS1,GPX4,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,SOCS3,STAT3,PTAFR,PTGIS,PTGS2,IDO1,IGF1,LDLR,LPCAT3,LPL,LRRK2,CSF1R,HK1"]
["GO:BP","growth hormone receptor signaling pathway via JAK-STAT","GO:0060397","0.000005220103382121813",14,235,5,18117,"STAT3,STAT5A,STAT5B,JAK2,LYN"]
["GO:BP","negative regulation of phagocytosis","GO:0050765","0.000005240774223611111",25,235,6,18117,"SIRPA,HMGB1,TGFB1,TLR2,CD300A,CD47"]
["GO:BP","neutrophil migration","GO:1990266","0.000005254530810400247",124,235,11,18117,"PIK3CG,C5AR1,FCER1G,SLIT2,CAMK1D,IL1R1,JAM3,CCL4,CCL5,CX3CL1,CXCL2"]
["GO:BP","positive regulation of nucleobase-containing compound metabolic process","GO:0045935","0.000005412331722475279",1887,235,50,18117,"MECOM,EGFR,ELF3,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NR1H3,NUPR1,P2RX7,ASH1L,ATM,HGF,SLC11A1,CAMK4,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKCQ,PRKD1,NFKB1,NFKBIA,HMGB1,HMGB2,HYAL2,IGF1,IL18,IL33,KPNA6,MAPK14,RBPJ,REL,TGFB1,TLR2,TLR4,CD28,CD81,TNFRSF1B,TNIP1,CEBPB,CIITA,CSRP3,DHX9,CX3CL1,DDX3X"]
["GO:BP","blood coagulation","GO:0007596","0.000005552963230699963",347,235,18,18117,"APOE,SERPINE1,P2RX1,P2RX7,AXL,PIK3CG,F3,F8,FCER1G,FN1,PLA2G4A,PRCP,PRKCA,PRKCQ,JAK2,LYN,THBS1,TLR4"]
["GO:BP","positive regulation of production of molecular mediator of immune response","GO:0002702","0.000005625985108147735",100,235,10,18117,"GPRC5B,PRKCZ,IL18,IL18R1,IL1R1,IL33,TLR4,CD28,CD81,HK1"]
["GO:BP","lipid catabolic process","GO:0016042","0.000006018520834509454",349,235,18,18117,"ABCD1,ABHD12,ACER3,MGLL,APOE,AOAH,PIK3CG,FABP4,PLA2G4A,PLA2G7,PLD3,PPARA,PPARD,LDLR,LIPA,LPL,RARRES2,DAGLB"]
["GO:BP","astrocyte differentiation","GO:0048708","0.000006037096637561155",78,235,9,18117,"EGFR,AGER,APP,NOTCH1,C5AR1,GRN,STAT3,LDLR,TLR4"]
["GO:BP","platelet degranulation","GO:0002576","0.000006122804276606781",126,235,11,18117,"APP,SERPINE1,P2RX1,F8,FN1,HGF,IGF1,LYN,RARRES2,THBS1,TIMP1"]
["GO:BP","negative regulation of protein metabolic process","GO:0051248","0.000006378178147258356",1151,235,36,18117,"EDNRB,EGFR,EIF2AK1,MFHAS1,APOE,APP,SERPINB9,SERPINE1,SERPINF1,NR1H3,PDCD4,FABP4,GSTP1,HGF,C3,SIRPA,SLIT2,SNCA,SOCS3,STAT3,PRKCZ,PTGS2,PTPN2,NFKB1,HYAL2,IGF1,IL1R2,LDLR,LRRK2,LXN,LYN,THBS1,TIMP1,CD300A,TNFAIP3,DDX3X"]
["GO:BP","hemostasis","GO:0007599","0.0000065022122048867825",351,235,18,18117,"APOE,SERPINE1,P2RX1,P2RX7,AXL,PIK3CG,F3,F8,FCER1G,FN1,PLA2G4A,PRCP,PRKCA,PRKCQ,JAK2,LYN,THBS1,TLR4"]
["GO:BP","astrocyte activation","GO:0048143","0.000006652241459960242",26,235,6,18117,"EGFR,AGER,APP,C5AR1,GRN,LDLR"]
["GO:BP","neuron differentiation","GO:0030182","0.000006798108886983497",1412,235,41,18117,"EDNRB,EGFR,EPHA2,AGER,APOE,APP,SERPINF1,RORA,RPS6KA5,NOTCH1,NOTCH2,BCL6,FGFR1,FN1,GJA1,GPRC5B,GRN,HDAC9,HGF,C3,SLIT2,CAMK1D,STAT3,PRKCA,PRKCQ,PRKCZ,PRKD1,HMGB1,JAK2,JAM3,LRRK2,LYN,RBPJ,TBC1D23,TRPV4,ULK4,CEBPB,CSF1R,DICER1,CX3CL1,DUOXA1"]
["GO:BP","cellular response to oxidative stress","GO:0034599","0.000006848008643130556",316,235,17,18117,"EGFR,ABCD1,ALOX5,AXL,FANCD2,GSTP1,HGF,SIRPA,SNCA,PRKD1,HMOX1,IL18RAP,JAK2,LRRK2,TLR4,TNFAIP3,CYBB"]
["GO:BP","negative regulation of extrinsic apoptotic signaling pathway via death domain receptors","GO:1902042","0.000006975406320579491",41,235,7,18117,"SERPINE1,HGF,HMGB2,HMOX1,ICAM1,TNFAIP3,DDX3X"]
["GO:BP","regulation of transforming growth factor beta production","GO:0071634","0.000006975406320579491",41,235,7,18117,"FN1,PTGS2,ITGB6,LGALS9,THBS1,CD200,CX3CL1"]
["GO:BP","transcription by RNA polymerase II","GO:0006366","0.000007059388783127841",2723,235,64,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AKNA,APOE,APP,SERPINE1,RORA,RPS6KA5,NOTCH1,NOTCH2,NR1H3,ASH1L,ATM,PDE2A,BCL6,C5AR1,HDAC9,HGF,SLC11A1,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKD1,PSMA1,PTAFR,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,IGF1,IL18,IL33,KIT,KPNA6,MAPK14,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD28,CD81,TNIP1,TRPV4,CEBPB,CIITA,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,DDX3X"]
["GO:BP","epithelial cell apoptotic process","GO:1904019","0.00000708615019125824",128,235,11,18117,"SERPINE1,NUPR1,PDCD4,PIK3CG,PPARA,HMOX1,ICAM1,JAK2,THBS1,CDH5,TNFAIP3"]
["GO:BP","regulation of growth","GO:0040008","0.000007087381337090133",681,235,26,18117,"EGFR,ADAM17,APOE,APP,NOTCH1,NOTCH2,ATRN,BCL6,FN1,GJA1,SLIT2,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,HYAL2,IGF1,MAPK14,RBPJ,TGFB1,CSF1,DDX3X"]
["GO:BP","regulation of extrinsic apoptotic signaling pathway via death domain receptors","GO:1902041","0.0000070959053307950156",59,235,8,18117,"SERPINE1,HGF,HMGB2,HMOX1,ICAM1,THBS1,TNFAIP3,DDX3X"]
["GO:BP","neutrophil chemotaxis","GO:0030593","0.000007241704405517903",103,235,10,18117,"PIK3CG,C5AR1,FCER1G,SLIT2,CAMK1D,JAM3,CCL4,CCL5,CX3CL1,CXCL2"]
["GO:BP","positive regulation of myeloid cell differentiation","GO:0045639","0.000007241704405517903",103,235,10,18117,"NOTCH2,STAT3,STAT5B,PRKCA,HMGB1,HMGB2,MAPK14,TGFB1,CSF1,CTNNBIP1"]
["GO:BP","multicellular organism reproduction","GO:0032504","0.000007241704405517903",865,235,30,18117,"EDNRB,EGFR,ACE,APP,SERPINF1,NOTCH1,P2RX1,ASH1L,ATM,AXL,BCL6,FANCA,FANCD2,GJA1,GPX4,HAVCR2,SLIT2,PPARD,STAT5B,PTAFR,PTGS2,HMGB2,IGF1,JAM3,KIT,KPNA6,LGALS9,LRRK2,TGFB1,DDX3X"]
["GO:BP","coagulation","GO:0050817","0.000007241704405517903",354,235,18,18117,"APOE,SERPINE1,P2RX1,P2RX7,AXL,PIK3CG,F3,F8,FCER1G,FN1,PLA2G4A,PRCP,PRKCA,PRKCQ,JAK2,LYN,THBS1,TLR4"]
["GO:BP","positive regulation of type I interferon production","GO:0032481","0.000007334633679904127",80,235,9,18117,"NFKB1,HMGB1,HMGB2,HSPD1,TLR2,TLR4,ZBP1,DHX9,DDX3X"]
["GO:BP","positive regulation of carbohydrate metabolic process","GO:0045913","0.000007334633679904127",80,235,9,18117,"APP,P2RX7,SNCA,PPARA,PTAFR,PTPN2,NFKB1,HMGB1,IGF1"]
["GO:BP","positive regulation of toll-like receptor 2 signaling pathway","GO:0034137","0.000007383694911550416",7,235,4,18117,"MFHAS1,PJA2,HMGB1,TLR1"]
["GO:BP","regulation of phagocytosis, engulfment","GO:0060099","0.000007482365649545356",15,235,5,18117,"APPL2,C3,PPARG,STAP1,CD300A"]
["GO:BP","regulation of cysteine-type endopeptidase activity involved in apoptotic process","GO:0043281","0.000007624713105527706",217,235,14,18117,"SERPINB9,P2RX1,F3,HGF,SNCA,PPARG,PTGS2,HMGB1,HSPD1,JAK2,LGALS9,THBS1,UACA,DDX3X"]
["GO:BP","positive regulation of lymphocyte differentiation","GO:0045621","0.00000786194563816769",104,235,10,18117,"AXL,BCL6,STAT5B,PRKCZ,NFKBID,IL18,IL2RA,LGALS9,RASGRP1,TGFB1"]
["GO:BP","arachidonic acid metabolic process","GO:0019369","0.000007984356856969286",60,235,8,18117,"ALOX5,MGLL,GPX4,PLA2G4A,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","regulation of mast cell activation","GO:0033003","0.00000811166339895973",42,235,7,18117,"ENPP3,HMOX1,LGALS9,LYN,CD300A,UNC13D,CNR2"]
["GO:BP","positive regulation of activated T cell proliferation","GO:0042104","0.000008226401491735505",27,235,6,18117,"AGER,STAT5B,HMGB1,IGF1,IL18,IL2RA"]
["GO:BP","regulation of toll-like receptor 4 signaling pathway","GO:0034143","0.000008226401491735505",27,235,6,18117,"MFHAS1,APPL2,NR1H3,HMGB1,LYN,TNFAIP3"]
["GO:BP","response to drug","GO:0042493","0.000008417107197236565",396,235,19,18117,"EGFR,ABCC1,ADAM17,AIM2,SCNN1B,PARP4,PDE2A,SNCA,PPARG,STAT3,PTGS2,HMOX1,HSPD1,ICAM1,LPL,LYN,TGFB1,THBS1,CYBB"]
["GO:BP","organic cyclic compound metabolic process","GO:1901360","0.000008435460305602203",6201,235,116,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,AGER,AIM2,AK7,AKNA,ALOX5,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,PLD3,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LRRK2,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","cellular nitrogen compound metabolic process","GO:0034641","0.000008440827354227331",6563,235,121,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCD1,ACE,ACER3,AGER,AIM2,AK7,AKNA,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX1,P2RX7,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,SGMS1,C5AR1,FABP4,FANCA,FANCD2,GJA1,GPX4,GSTP1,HAVCR2,HCK,HDAC9,HGF,SIRPA,SLC11A1,CAMK1D,CAMK4,PLD3,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LGALS9,LRRK2,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD47,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CERS6,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DNASE1,DROSHA,HK1"]
["GO:BP","regulation of epithelial cell apoptotic process","GO:1904035","0.000008505822738950865",105,235,10,18117,"SERPINE1,NUPR1,PDCD4,PPARA,HMOX1,ICAM1,JAK2,THBS1,CDH5,TNFAIP3"]
["GO:BP","gland development","GO:0048732","0.000008691395717405416",436,235,20,18117,"EGFR,ELF3,EPHA2,SERPINF1,NOTCH1,NOTCH2,ASH1L,ATM,HGF,STAT5A,STAT5B,HMOX1,JAK2,RBPJ,TGFB1,TGM2,TNFAIP3,CEBPB,CSF1,CSF1R"]
["GO:BP","immune response-activating cell surface receptor signaling pathway","GO:0002429","0.0000089588979831786",477,235,21,18117,"APPL2,RPS6KA5,C5AR1,FCER1G,FPR1,FPR3,HCK,STAP1,PRKCQ,PSMA1,PTPN2,NFKB1,NFKBID,LYN,RELB,THEMIS2,CD28,CD300A,CD47,CD81,CMKLR1"]
["GO:BP","immune response-activating signal transduction","GO:0002757","0.0000089588979831786",477,235,21,18117,"APPL2,RPS6KA5,C5AR1,FCER1G,FPR1,FPR3,HCK,STAP1,PRKCQ,PSMA1,PTPN2,NFKB1,NFKBID,LYN,RELB,THEMIS2,CD28,CD300A,CD47,CD81,CMKLR1"]
["GO:BP","biological process involved in interaction with host","GO:0051701","0.00000932730626773193",221,235,14,18117,"EGFR,EPHA2,SERPINB9,AXL,SLAMF1,HYAL2,ICAM1,ITGB6,KPNA6,LDLR,LGALS9,CD81,TNIP1,CIITA"]
["GO:BP","platelet activation","GO:0030168","0.000009398035499624327",160,235,12,18117,"APOE,P2RX1,AXL,PIK3CG,F8,FCER1G,FN1,PLA2G4A,PRKCA,PRKCQ,LYN,TLR4"]
["GO:BP","transforming growth factor beta production","GO:0071604","0.000009439852283488295",43,235,7,18117,"FN1,PTGS2,ITGB6,LGALS9,THBS1,CD200,CX3CL1"]
["GO:BP","carboxylic acid metabolic process","GO:0019752","0.000009729707297913261",1024,235,33,18117,"ABCC1,ABCD1,ALOX5,ALOX5AP,MGLL,APP,APPL2,AOAH,NR1H3,NUPR1,P2RX7,GPX4,GSTP1,C3,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STAT3,PSMA1,PTGIS,PTGS1,PTGS2,IDO1,IGF1,KIT,LPL,MAPK14,MAPKAPK2,TLR2,DAGLB,HK1"]
["GO:BP","natural killer cell mediated cytotoxicity","GO:0042267","0.000010114023466227271",62,235,8,18117,"SERPINB9,HAVCR2,STAT5B,IL18,IL18RAP,LGALS9,RASGRP1,UNC13D"]
["GO:BP","positive regulation of phospholipase activity","GO:0010518","0.000010114023466227271",62,235,8,18117,"EDNRA,EGFR,C5AR1,FGFR1,PRKCZ,PTAFR,KIT,CCL5"]
["GO:BP","positive regulation of type 2 immune response","GO:0002830","0.000010463549322754466",16,235,5,18117,"PRKCZ,IDO1,IL18,IL33,CD81"]
["GO:BP","anatomical structure homeostasis","GO:0060249","0.000010463549322754466",482,235,21,18117,"EGFR,NOTCH1,P2RX1,P2RX7,ATM,GJA1,STK39,PRKCA,PRKCQ,PTGS2,ITGB6,JAM3,LIPA,TCIRG1,TGFB1,TLR4,CDH5,TNFAIP3,CSF1,CSF1R,CX3CL1"]
["GO:BP","regulation of membrane invagination","GO:1905153","0.000010463549322754466",16,235,5,18117,"APPL2,C3,PPARG,STAP1,CD300A"]
["GO:BP","positive regulation of nitric-oxide synthase biosynthetic process","GO:0051770","0.000010463549322754466",16,235,5,18117,"IL33,JAK2,LRRK2,TLR2,TLR4"]
["GO:BP","astrocyte development","GO:0014002","0.000010979949103497589",44,235,7,18117,"EGFR,AGER,APP,C5AR1,GRN,LDLR,TLR4"]
["GO:BP","regulation of T cell migration","GO:2000404","0.000010979949103497589",44,235,7,18117,"ADAM17,APP,SPN,STK39,CCL5,CCR2,CD200"]
["GO:BP","Notch signaling pathway","GO:0007219","0.000011226410560187109",193,235,13,18117,"EGFR,ELF3,ADAM17,APP,NOTCH1,NOTCH2,BCL6,STAT3,NFKBIA,IL2RA,KIT,RBPJ,TGFB1"]
["GO:BP","regulation of lymphocyte migration","GO:2000401","0.000011344437225754003",63,235,8,18117,"ADAM17,APP,SPN,STK39,CCL4,CCL5,CCR2,CD200"]
["GO:BP","myelination","GO:0042552","0.000011448186551900293",135,235,11,18117,"ABCD1,ACER3,ATRN,HGF,PMP22,JAM3,TGFB1,TLR2,TNFRSF1B,CTSC,DICER1"]
["GO:BP","regulation of tube diameter","GO:0035296","0.000011448186551900293",135,235,11,18117,"EDNRA,EDNRB,EGFR,ACE,APOE,SCNN1B,P2RX1,GJA1,PTAFR,PTGS2,ICAM1"]
["GO:BP","blood vessel diameter maintenance","GO:0097746","0.000011448186551900293",135,235,11,18117,"EDNRA,EDNRB,EGFR,ACE,APOE,SCNN1B,P2RX1,GJA1,PTAFR,PTGS2,ICAM1"]
["GO:BP","establishment of organelle localization","GO:0051656","0.000011612860974241486",445,235,20,18117,"MCPH1,ATM,PIK3CG,F8,GJA1,SNAP23,SNCA,PRKCZ,PTGDR,HMOX1,KIT,LGALS9,LRRK2,LYN,RASGRP1,TBC1D23,TCIRG1,CD300A,UNC13D,CTSC"]
["GO:BP","macromolecule biosynthetic process","GO:0009059","0.000011864283069715353",5114,235,100,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,AGER,AIM2,AKNA,APOE,APP,SDC1,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,GSTP1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,LRRK2,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","cellular aromatic compound metabolic process","GO:0006725","0.000011905549345595579",5956,235,112,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,AGER,AIM2,AK7,AKNA,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,PLD3,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,ITGAM,JAK2,KIT,KPNA6,LGALS9,LRRK2,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","regulation of tube size","GO:0035150","0.000012255191996609689",136,235,11,18117,"EDNRA,EDNRB,EGFR,ACE,APOE,SCNN1B,P2RX1,GJA1,PTAFR,PTGS2,ICAM1"]
["GO:BP","dendritic cell migration","GO:0036336","0.00001246316022854071",29,235,6,18117,"ALOX5,PIK3CG,HMGB1,LGALS9,CCL5,CCR2"]
["GO:BP","multi-multicellular organism process","GO:0044706","0.000012474044600088043",227,235,14,18117,"P2RX1,ASH1L,GJA1,HAVCR2,PPARD,STAT5B,PTAFR,PTGFR,PTGS2,IDO1,KPNA6,LGALS9,TGFB1,TIMP1"]
["GO:BP","RNA metabolic process","GO:0016070","0.000012542596934280852",4710,235,94,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PDCD4,PDE2A,BCL6,C5AR1,FABP4,FANCA,FANCD2,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DROSHA"]
["GO:BP","lipid localization","GO:0010876","0.000012642608800163338",530,235,22,18117,"ABCC1,ABCD1,ACE,APOE,NR1H3,P2RX7,FABP4,GJA1,C3,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STAT5B,PTPN2,NFKB1,NFKBIA,LDLR,LPCAT3,LPL,THBS1"]
["GO:BP","regulation of natural killer cell mediated immunity","GO:0002715","0.000012642608800163338",45,235,7,18117,"SERPINB9,HAVCR2,STAT5B,IL18RAP,LGALS9,RASGRP1,CD96"]
["GO:BP","positive regulation of JNK cascade","GO:0046330","0.000012907533655928006",86,235,9,18117,"AGER,MFHAS1,APP,SLAMF1,PJA2,HMGB1,RASGRP1,TLR4,TRPV4"]
["GO:BP","cellular response to interleukin-18","GO:0071351","0.00001379415012689962",8,235,4,18117,"ALOX5,IL18,IL18R1,IL18RAP"]
["GO:BP","monocyte extravasation","GO:0035696","0.00001379415012689962",8,235,4,18117,"AGER,SIRPA,CCR2,CD47"]
["GO:BP","interleukin-18-mediated signaling pathway","GO:0035655","0.00001379415012689962",8,235,4,18117,"ALOX5,IL18,IL18R1,IL18RAP"]
["GO:BP","negative regulation of mast cell activation involved in immune response","GO:0033007","0.00001379415012689962",8,235,4,18117,"ENPP3,HMOX1,LGALS9,CD300A"]
["GO:BP","negative regulation of myeloid leukocyte mediated immunity","GO:0002887","0.00001379415012689962",8,235,4,18117,"HMOX1,LGALS9,CCR2,CD300A"]
["GO:BP","microglial cell proliferation","GO:0061518","0.00001379415012689962",8,235,4,18117,"IL33,CSF1,CSF1R,CX3CL1"]
["GO:BP","heterocycle metabolic process","GO:0046483","0.000013932997053843225",5904,235,111,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,AGER,AIM2,AK7,AKNA,ALOX5,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,PLD3,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,LRRK2,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DNASE1,DROSHA,HK1"]
["GO:BP","nitric oxide metabolic process","GO:0046209","0.000014083171256104179",87,235,9,18117,"RORA,SIRPA,PTGIS,PTGS2,ICAM1,JAK2,TLR2,TLR4,CD47"]
["GO:BP","regulation of fibroblast proliferation","GO:0048145","0.000014083171256104179",87,235,9,18117,"NUPR1,FN1,GSTP1,PPARG,NDUFS4,IGF1,TGFB1,CD300A,DHX9"]
["GO:BP","MHC class II biosynthetic process","GO:0045342","0.00001419494879680497",17,235,5,18117,"SLC11A1,IL33,JAK2,TLR4,CIITA"]
["GO:BP","long-chain fatty acid metabolic process","GO:0001676","0.00001466481617054194",112,235,10,18117,"ABCD1,ALOX5,MGLL,GPX4,GSTP1,PLA2G4A,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","regulation of interferon-alpha production","GO:0032647","0.000015081380667492403",30,235,6,18117,"HAVCR2,HMGB1,HSPD1,TLR4,DHX9,DDX3X"]
["GO:BP","interferon-alpha production","GO:0032607","0.000015081380667492403",30,235,6,18117,"HAVCR2,HMGB1,HSPD1,TLR4,DHX9,DDX3X"]
["GO:BP","reactive nitrogen species metabolic process","GO:2001057","0.000015383876793358022",88,235,9,18117,"RORA,SIRPA,PTGIS,PTGS2,ICAM1,JAK2,TLR2,TLR4,CD47"]
["GO:BP","fibroblast proliferation","GO:0048144","0.000015383876793358022",88,235,9,18117,"NUPR1,FN1,GSTP1,PPARG,NDUFS4,IGF1,TGFB1,CD300A,DHX9"]
["GO:BP","interferon-gamma-mediated signaling pathway","GO:0060333","0.000015383876793358022",88,235,9,18117,"NR1H3,HCK,PPARG,SOCS3,PTAFR,PTPN2,ICAM1,JAK2,CIITA"]
["GO:BP","cellular lipid catabolic process","GO:0044242","0.00001572645343818063",232,235,14,18117,"ABCD1,ABHD12,ACER3,MGLL,AOAH,PIK3CG,FABP4,PLA2G4A,PLA2G7,PPARA,PPARD,LDLR,LPL,DAGLB"]
["GO:BP","regulation of macrophage colony-stimulating factor signaling pathway","GO:1902226","0.000015746908702106676",3,235,3,18117,"STAP1,PTPN2,CSF1"]
["GO:BP","interleukin-33-mediated signaling pathway","GO:0038172","0.000015746908702106676",3,235,3,18117,"IL1RAP,IL1RL1,IL33"]
["GO:BP","leukotriene production involved in inflammatory response","GO:0002540","0.000015746908702106676",3,235,3,18117,"ALOX5,ALOX5AP,SERPINE1"]
["GO:BP","arachidonic acid metabolite production involved in inflammatory response","GO:0002538","0.000015746908702106676",3,235,3,18117,"ALOX5,ALOX5AP,SERPINE1"]
["GO:BP","fatty acid biosynthetic process","GO:0006633","0.000016823170318218633",170,235,12,18117,"ABCD1,ALOX5,MGLL,NR1H3,GPX4,GSTP1,PLA2G4A,PTGIS,PTGS1,PTGS2,LPL,DAGLB"]
["GO:BP","viral entry into host cell","GO:0046718","0.00001687217927470994",141,235,11,18117,"EGFR,EPHA2,AXL,SLAMF1,HYAL2,ICAM1,ITGB6,LDLR,LGALS9,CD81,CIITA"]
["GO:BP","acylglycerol metabolic process","GO:0006639","0.00001687217927470994",141,235,11,18117,"ABHD12,MGLL,APOE,NR1H3,PIK3CG,FABP4,C3,PLA2G4A,LDLR,LPL,DAGLB"]
["GO:BP","positive regulation of alpha-beta T cell activation","GO:0046635","0.000017459405632355704",67,235,8,18117,"PRKCQ,PRKCZ,NFKBID,IL18,LGALS9,CCR2,CD28,CD81"]
["GO:BP","catabolic process","GO:0009056","0.000018078029821337733",2744,235,63,18117,"EGFR,ENPP3,ABCD1,ABHD12,ACE,ACER3,ADAMTS12,ALDH2,MGLL,APOE,APP,AOAH,SDC1,RPS19,NUPR1,P2RX7,ATM,PDE2A,PDE5A,PIK3CG,FABP4,GJA1,HGF,SLC11A1,PLA2G4A,PLA2G7,PLD3,SNCA,PPARA,PPARD,STAT3,PRKCA,PRKD1,PSMA1,HMGB1,HMGB2,HMOX1,HYAL2,IDO1,IGF1,IL33,LDLR,LIPA,LPL,LRRK2,MAPK14,MAPKAPK2,RARRES2,TCIRG1,TIMP1,CD81,TNFAIP3,TNFRSF1B,VPS35,CTSC,CTSS,DHX9,DICER1,CYLD,DAGLB,DNASE1,DROSHA,HK1"]
["GO:BP","regulation of protein transport","GO:0051223","0.000018095741785157047",586,235,23,18117,"EGFR,ALOX5,APOE,NR1H3,GJA1,PPARD,PRKCA,PRKCZ,PRKD1,PTGS2,HYAL2,IGF1,ITGAM,JAK2,LRRK2,MAPK14,TCIRG1,TGFB1,TLR2,TLR4,CCL5,CD200,CD81"]
["GO:BP","negative regulation of exocytosis","GO:0045920","0.000018133031662754383",31,235,6,18117,"NOTCH1,SNCA,HMOX1,LGALS9,CCR2,CD300A"]
["GO:BP","positive regulation of T cell migration","GO:2000406","0.000018133031662754383",31,235,6,18117,"ADAM17,APP,SPN,STK39,CCL5,CCR2"]
["GO:BP","regulation of mast cell activation involved in immune response","GO:0033006","0.000018133031662754383",31,235,6,18117,"ENPP3,HMOX1,LGALS9,LYN,CD300A,UNC13D"]
["GO:BP","oxoacid metabolic process","GO:0043436","0.000018154330782097123",1057,235,33,18117,"ABCC1,ABCD1,ALOX5,ALOX5AP,MGLL,APP,APPL2,AOAH,NR1H3,NUPR1,P2RX7,GPX4,GSTP1,C3,PLA2G4A,SNCA,PPARA,PPARD,PPARG,STAT3,PSMA1,PTGIS,PTGS1,PTGS2,IDO1,IGF1,KIT,LPL,MAPK14,MAPKAPK2,TLR2,DAGLB,HK1"]
["GO:BP","CD4-positive, alpha-beta T cell cytokine production","GO:0035743","0.00001892831593587293",18,235,5,18117,"PRKCZ,IL18,IL18R1,IL1R1,CD81"]
["GO:BP","regulation of cholesterol storage","GO:0010885","0.00001892831593587293",18,235,5,18117,"NR1H3,PPARA,PPARD,PPARG,LPL"]
["GO:BP","positive chemotaxis","GO:0050918","0.000019364075962400706",68,235,8,18117,"AGER,F3,HGF,HMGB1,HMGB2,IL16,CCL5,CX3CL1"]
["GO:BP","unsaturated fatty acid metabolic process","GO:0033559","0.000019619536261948526",116,235,10,18117,"ABCD1,ALOX5,MGLL,GPX4,GSTP1,PLA2G4A,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","response to ketone","GO:1901654","0.000019619536261948526",204,235,13,18117,"EGFR,SCNN1B,SERPINF1,NR1H3,SLIT2,PPARG,PTAFR,PTGFR,ICAM1,TGFB1,THBS1,TLR2,CYBB"]
["GO:BP","positive regulation of viral process","GO:0048524","0.00001988649524865265",91,235,9,18117,"NOTCH1,AXL,PPARA,KPNA6,LGALS9,CCL5,CD28,DHX9,DDX3X"]
["GO:BP","positive regulation of T cell differentiation","GO:0045582","0.00001988649524865265",91,235,9,18117,"BCL6,STAT5B,PRKCZ,NFKBID,IL18,IL2RA,LGALS9,RASGRP1,TGFB1"]
["GO:BP","regulation of regulated secretory pathway","GO:1903305","0.000020351994204861154",144,235,11,18117,"NOTCH1,P2RX1,PTAFR,HMOX1,ITGAM,LGALS9,LRRK2,LYN,CCR2,CD300A,UNC13D"]
["GO:BP","activation of innate immune response","GO:0002218","0.000020351994204861154",144,235,11,18117,"AIM2,RPS6KA5,FCER1G,HCK,PSMA1,NFKB1,HMGB1,LYN,RELB,TLR4,ZBP1"]
["GO:BP","protein import","GO:0017038","0.000020590553409438278",205,235,13,18117,"APOE,APPL2,STAT3,PRKD1,PTGS2,NFKBIA,HSPD1,HYAL2,JAK2,KPNA6,LRRK2,MAPK14,TGFB1"]
["GO:BP","nucleobase-containing compound metabolic process","GO:0006139","0.000021918802786615723",5746,235,108,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,ENPP3,EPHA2,ABCD1,AGER,AIM2,AK7,AKNA,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,P2RX7,ASH1L,ATM,PARP4,PDCD4,PDE2A,PDE5A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,PLD3,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,LRRK2,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DNASE1,DROSHA,HK1"]
["GO:BP","regulation of exocytosis","GO:0017157","0.000022868403181757744",207,235,13,18117,"SDC1,NOTCH1,P2RX1,SNCA,PTAFR,HMOX1,ITGAM,LGALS9,LRRK2,LYN,CCR2,CD300A,UNC13D"]
["GO:BP","response to glucocorticoid","GO:0051384","0.00002317610195820537",146,235,11,18117,"EGFR,SDC1,SERPINF1,GSTP1,SLIT2,PTAFR,PTGS2,HMGB1,HSPD1,ICAM1,TGFB1"]
["GO:BP","T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell","GO:0002291","0.000023479870341791038",9,235,4,18117,"HAVCR2,ICAM1,LGALS9,CD81"]
["GO:BP","negative regulation of secretion","GO:0051048","0.000023493329401289435",176,235,12,18117,"APOE,NOTCH1,NR1H3,GJA1,SNCA,STK39,HMOX1,LGALS9,CCR2,CD200,CD300A,TNFRSF1B"]
["GO:BP","bone remodeling","GO:0046849","0.000023617571645488867",93,235,9,18117,"EGFR,EPHA2,NOTCH2,P2RX7,GJA1,PRKCA,TCIRG1,TNFAIP3,CSF1R"]
["GO:BP","acute-phase response","GO:0006953","0.000024864604977595124",50,235,7,18117,"EDNRB,F8,FN1,STAT3,PTGS2,CD163,CEBPB"]
["GO:BP","regulation of protein tyrosine kinase activity","GO:0061097","0.000028146810205083573",95,235,9,18117,"ACE,ADAM17,APP,GPRC5B,STAP1,PTPN2,HYAL2,CCL5,CSF1R"]
["GO:BP","regulation of DNA binding","GO:0051101","0.000028302474000320972",121,235,10,18117,"AGER,PPARG,NFKBIA,HMGB1,HMGB2,HMOX1,IGF1,JAK2,TGFB1,CTNNBIP1"]
["GO:BP","lipid biosynthetic process","GO:0008610","0.00002885593805905796",740,235,26,18117,"ABCD1,ACER3,ALOX5,MGLL,APOE,NR1H3,P2RX1,ATM,PIK3CG,SGMS1,GPX4,GSTP1,C3,PLA2G4A,PPARA,PPARD,PRKD1,PTGIS,PTGS1,PTGS2,NFKB1,LDLR,LPCAT3,LPL,CERS6,DAGLB"]
["GO:BP","negative regulation of cellular protein metabolic process","GO:0032269","0.000029193775607075418",1082,235,33,18117,"EDNRB,EIF2AK1,MFHAS1,APOE,APP,SERPINB9,SERPINE1,SERPINF1,NR1H3,PDCD4,FABP4,GSTP1,HGF,C3,SIRPA,SLIT2,SNCA,SOCS3,STAT3,PRKCZ,PTGS2,PTPN2,NFKB1,HYAL2,IL1R2,LRRK2,LXN,LYN,THBS1,TIMP1,CD300A,TNFAIP3,DDX3X"]
["GO:BP","developmental process involved in reproduction","GO:0003006","0.00002947587789800571",982,235,31,18117,"ACE,SDC1,SERPINF1,NOTCH1,NOTCH2,NUPR1,ASH1L,ATM,AXL,BCL6,FANCA,GJA1,GPX4,C3,SLIT2,PPARD,PPARG,SOCS3,STAT5B,PTGS2,HMGB2,ICAM1,IGF1,JAM3,KIT,LRRK2,MAPK14,RBPJ,TGFB1,CEBPB,CSF1"]
["GO:BP","positive regulation of epithelial cell migration","GO:0010634","0.000031114904393678864",181,235,12,18117,"ADAM17,PIK3CG,FGFR1,GRN,HDAC9,STAT5A,PRKCA,PRKD1,PTGS2,HMGB1,HMOX1,THBS1"]
["GO:BP","regulation of cellular extravasation","GO:0002691","0.00003115520682082524",34,235,6,18117,"AGER,PTAFR,ICAM1,IL1R1,JAM3,CCR2"]
["GO:BP","positive regulation of stress-activated protein kinase signaling cascade","GO:0070304","0.00003240492433337552",123,235,10,18117,"AGER,MFHAS1,APP,SLAMF1,PJA2,HMGB1,LYN,RASGRP1,TLR4,TRPV4"]
["GO:BP","cholesterol storage","GO:0010878","0.00003240492433337552",20,235,5,18117,"NR1H3,PPARA,PPARD,PPARG,LPL"]
["GO:BP","regulation of monocyte chemotactic protein-1 production","GO:0071637","0.00003240492433337552",20,235,5,18117,"AGER,GSTP1,HMGB1,LGALS9,TRPV4"]
["GO:BP","negative regulation of interleukin-6 production","GO:0032715","0.00003240492433337552",73,235,8,18117,"HAVCR2,HGF,SIRPA,SLAMF1,TLR4,CD200,TNFAIP3,CX3CL1"]
["GO:BP","monocyte chemotactic protein-1 production","GO:0071605","0.00003240492433337552",20,235,5,18117,"AGER,GSTP1,HMGB1,LGALS9,TRPV4"]
["GO:BP","positive regulation of T cell cytokine production","GO:0002726","0.00003240492433337552",20,235,5,18117,"PRKCZ,IL18,IL18R1,IL1R1,CD81"]
["GO:BP","regulation of myeloid leukocyte differentiation","GO:0002761","0.00003240492433337552",123,235,10,18117,"NOTCH2,CAMK4,PRKCA,PTPN2,LYN,TGFB1,TLR4,CEBPB,CSF1,CTNNBIP1"]
["GO:BP","interleukin-13 production","GO:0032616","0.00003240492433337552",20,235,5,18117,"PRKCZ,IL18,IL1RAP,IL33,LGALS9"]
["GO:BP","negative regulation of NF-kappaB transcription factor activity","GO:0032088","0.000032912830610437166",97,235,9,18117,"AIM2,HAVCR2,PTGIS,NFKBIA,IRAK2,CD200,TNFAIP3,CMKLR1,CYLD"]
["GO:BP","response to purine-containing compound","GO:0014074","0.000033370759219320774",152,235,11,18117,"APP,SDC1,P2RX1,P2RX7,PDE2A,PIK3CG,PPARG,PTAFR,PTGS2,NDUFS4,HSPD1"]
["GO:BP","negative regulation of secretion by cell","GO:1903531","0.000033370759219320774",152,235,11,18117,"APOE,NOTCH1,NR1H3,GJA1,SNCA,HMOX1,LGALS9,CCR2,CD200,CD300A,TNFRSF1B"]
["GO:BP","protein import into nucleus","GO:0006606","0.000033370759219320774",152,235,11,18117,"APPL2,STAT3,PRKD1,PTGS2,NFKBIA,HYAL2,JAK2,KPNA6,LRRK2,MAPK14,TGFB1"]
["GO:BP","regulation of establishment of protein localization","GO:0070201","0.0000345115760175922",611,235,23,18117,"EGFR,ALOX5,APOE,NR1H3,GJA1,PPARD,PRKCA,PRKCZ,PRKD1,PTGS2,HYAL2,IGF1,ITGAM,JAK2,LRRK2,MAPK14,TCIRG1,TGFB1,TLR2,TLR4,CCL5,CD200,CD81"]
["GO:BP","neuron apoptotic process","GO:0051402","0.00003535155473507598",250,235,14,18117,"APOE,APP,NUPR1,ATM,AXL,C5AR1,GRN,SNCA,HMOX1,HSPD1,ITGAM,JAK2,CEBPB,CX3CL1"]
["GO:BP","response to nutrient levels","GO:0031667","0.0000353599338600824",482,235,20,18117,"EGFR,EIF2AK1,APOE,APPL2,GSTP1,PPARA,PPARD,PPARG,PRKD1,PTGS2,HMOX1,ICAM1,LDLR,LPL,LRRK2,RARRES2,TGFB1,CD68,TRPV4,CYBB"]
["GO:BP","regulation of neuron apoptotic process","GO:0043523","0.0000353599338600824",216,235,13,18117,"APOE,NUPR1,ATM,AXL,C5AR1,GRN,SNCA,HMOX1,HSPD1,ITGAM,JAK2,CEBPB,CX3CL1"]
["GO:BP","negative regulation of lipid localization","GO:1905953","0.00003537225824680979",74,235,8,18117,"NR1H3,PPARA,PPARD,PPARG,PTPN2,NFKB1,NFKBIA,THBS1"]
["GO:BP","cellular response to interleukin-6","GO:0071354","0.00003605574977382848",53,235,7,18117,"SOCS3,STAT3,PTGIS,PTPN2,NFKB1,ICAM1,JAK2"]
["GO:BP","negative regulation of epithelial cell apoptotic process","GO:1904036","0.00003605574977382848",53,235,7,18117,"SERPINE1,NUPR1,PPARA,HMOX1,ICAM1,CDH5,TNFAIP3"]
["GO:BP","small molecule biosynthetic process","GO:0044283","0.00003621662238326716",704,235,25,18117,"ENPP3,ABCD1,ACER3,ALOX5,ALOX5AP,MGLL,APOE,NR1H3,PDE2A,PDE5A,GPX4,GSTP1,PLA2G4A,SNCA,PPARA,PTAFR,PTGIS,PTGS1,PTGS2,PTPN2,NFKB1,IDO1,LPCAT3,LPL,DAGLB"]
["GO:BP","leukotriene metabolic process","GO:0006691","0.000036332623625871894",35,235,6,18117,"ABCC1,ALOX5,ALOX5AP,PLA2G4A,MAPKAPK2,TLR2"]
["GO:BP","regulation of I-kappaB kinase/NF-kappaB signaling","GO:0043122","0.00003668740644775828",251,235,14,18117,"RORA,ASH1L,GJA1,GPRC5B,GSTP1,PRKD1,HMOX1,LGALS9,REL,TGM2,TLR4,TNFAIP3,TNIP1,CX3CL1"]
["GO:BP","positive regulation of cysteine-type endopeptidase activity","GO:2001056","0.0000372300101306858",154,235,11,18117,"AIM2,P2RX1,F3,SNCA,PPARG,HMGB1,HSPD1,JAK2,LGALS9,UACA,DDX3X"]
["GO:BP","negative regulation of cholesterol storage","GO:0010887","0.0000372300101306858",10,235,4,18117,"NR1H3,PPARA,PPARD,PPARG"]
["GO:BP","negative regulation of leukocyte degranulation","GO:0043301","0.0000372300101306858",10,235,4,18117,"HMOX1,LGALS9,CCR2,CD300A"]
["GO:BP","entry into host","GO:0044409","0.0000372300101306858",154,235,11,18117,"EGFR,EPHA2,AXL,SLAMF1,HYAL2,ICAM1,ITGB6,LDLR,LGALS9,CD81,CIITA"]
["GO:BP","positive regulation of interleukin-5 production","GO:0032754","0.0000372300101306858",10,235,4,18117,"PRKCZ,IL1RAP,IL1RL1,IL33"]
["GO:BP","regulation of interleukin-8 production","GO:0032677","0.000038168425907068576",99,235,9,18117,"SERPINE1,F3,STAT3,HMGB1,HYAL2,LGALS9,TLR1,TLR2,TLR4"]
["GO:BP","positive regulation of Ras protein signal transduction","GO:0046579","0.00003864289193804701",75,235,8,18117,"NOTCH1,NOTCH2,PIK3CG,IGF1,JAK2,LYN,RASGRP1,CSF1"]
["GO:BP","regulation of peptide transport","GO:0090087","0.00004081566106580102",618,235,23,18117,"EGFR,ALOX5,APOE,NR1H3,GJA1,PPARD,PRKCA,PRKCZ,PRKD1,PTGS2,HYAL2,IGF1,ITGAM,JAK2,LRRK2,MAPK14,TCIRG1,TGFB1,TLR2,TLR4,CCL5,CD200,CD81"]
["GO:BP","positive regulation of alpha-beta T cell proliferation","GO:0046641","0.00004093585572908433",21,235,5,18117,"IL18,LGALS9,CCR2,CD28,CD81"]
["GO:BP","positive regulation of lymphocyte chemotaxis","GO:0140131","0.00004093585572908433",21,235,5,18117,"ADAM17,STK39,CCL4,CCL5,CCR2"]
["GO:BP","pulmonary valve development","GO:0003177","0.00004093585572908433",21,235,5,18117,"NOTCH1,NOTCH2,SLIT2,RBPJ,TNFRSF1B"]
["GO:BP","sterol homeostasis","GO:0055092","0.000041204293465525956",100,235,9,18117,"ABCD1,APOE,RORA,NR1H3,FABP4,HDAC9,IL18,LDLR,LPL"]
["GO:BP","negative regulation of DNA-binding transcription factor activity","GO:0043433","0.000041804232789360286",187,235,12,18117,"AIM2,NUPR1,HAVCR2,PTGIS,NFKBIA,HMOX1,IRAK2,CD200,TNFAIP3,CMKLR1,CTNNBIP1,CYLD"]
["GO:BP","positive regulation of interferon-beta production","GO:0032728","0.000042425998714581116",36,235,6,18117,"HMGB1,HMGB2,TLR2,TLR4,DHX9,DDX3X"]
["GO:BP","positive regulation of endocytosis","GO:0045807","0.000044584813327233435",101,235,9,18117,"APOE,APPL2,SERPINE1,AXL,C3,SNCA,PPARG,STAP1,LRRK2"]
["GO:BP","glial cell proliferation","GO:0014009","0.00004547667876518547",55,235,7,18117,"NOTCH1,IL33,LYN,CSF1,CSF1R,DICER1,CX3CL1"]
["GO:BP","heart development","GO:0007507","0.000045697316834930206",578,235,22,18117,"EDNRA,EGFR,NOTCH1,NOTCH2,ATM,PDCD4,PDE2A,FN1,GJA1,HDAC9,SLIT2,CALCRL,PPARA,PPARD,PPARG,NDST1,IGF1,MAPK14,RBPJ,TGFB1,TNFRSF1B,CSRP3"]
["GO:BP","fatty acid transport","GO:0015908","0.00004695202758441819",158,235,11,18117,"ABCD1,ACE,APOE,FABP4,GJA1,PLA2G4A,SNCA,PPARA,PPARD,PPARG,THBS1"]
["GO:BP","icosanoid biosynthetic process","GO:0046456","0.00005123785619743696",56,235,7,18117,"ALOX5,ALOX5AP,PLA2G4A,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","regulation of calcium ion transport","GO:0051924","0.00005141914954297582",259,235,14,18117,"P2RX1,P2RX7,PIK3CG,GJA1,SNCA,PRKD1,PTGS2,ICAM1,IL16,LYN,TGFB1,CCL4,CCL5,CX3CL1"]
["GO:BP","negative regulation of regulated secretory pathway","GO:1903306","0.00005179624474599087",22,235,5,18117,"NOTCH1,HMOX1,LGALS9,CCR2,CD300A"]
["GO:BP","positive regulation of transforming growth factor beta production","GO:0071636","0.00005179624474599087",22,235,5,18117,"PTGS2,LGALS9,THBS1,CD200,CX3CL1"]
["GO:BP","nucleic acid metabolic process","GO:0090304","0.00005563808513849295",5226,235,99,18117,"MCPH1,MECOM,EDNRB,EGFR,ELF3,ENPP3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,PLD3,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,MAPKAPK2,RBPJ,REL,RELB,TGFB1,TLR2,TLR4,CD200,CD28,CD81,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X,DNASE1,DROSHA"]
["GO:BP","monocarboxylic acid biosynthetic process","GO:0072330","0.00005587644189662887",226,235,13,18117,"ABCD1,ALOX5,MGLL,NR1H3,GPX4,GSTP1,PLA2G4A,PTGIS,PTGS1,PTGS2,IDO1,LPL,DAGLB"]
["GO:BP","interleukin-8 production","GO:0032637","0.00005610731064277598",104,235,9,18117,"SERPINE1,F3,STAT3,HMGB1,HYAL2,LGALS9,TLR1,TLR2,TLR4"]
["GO:BP","behavior","GO:0007610","0.00005617965251810961",586,235,22,18117,"EGFR,ABHD12,AGER,APOE,APP,SCN9A,SERPINF1,GJA1,CAMK4,PJA2,SNCA,PPARA,STAT3,PRKCZ,PTGS2,IDO1,KIT,LDLR,LRRK2,THBS1,TLR2,CEBPB"]
["GO:BP","response to interleukin-18","GO:0070673","0.00005631842743384531",11,235,4,18117,"ALOX5,IL18,IL18R1,IL18RAP"]
["GO:BP","positive regulation of interleukin-13 production","GO:0032736","0.00005631842743384531",11,235,4,18117,"PRKCZ,IL1RAP,IL33,LGALS9"]
["GO:BP","positive regulation of MHC class II biosynthetic process","GO:0045348","0.00005631842743384531",11,235,4,18117,"IL33,JAK2,TLR4,CIITA"]
["GO:BP","positive regulation of dendritic cell differentiation","GO:2001200","0.000056590393132931616",4,235,3,18117,"AGER,HMGB1,LGALS9"]
["GO:BP","response to caloric restriction","GO:0061771","0.000056590393132931616",4,235,3,18117,"APOE,LDLR,RARRES2"]
["GO:BP","response to interleukin-6","GO:0070741","0.00005697134629326646",57,235,7,18117,"SOCS3,STAT3,PTGIS,PTPN2,NFKB1,ICAM1,JAK2"]
["GO:BP","negative regulation of phosphate metabolic process","GO:0045936","0.0000575298647621044",543,235,21,18117,"MFHAS1,APOE,NUPR1,PDCD4,FABP4,GSTP1,HGF,SIRPA,SLIT2,SNCA,PPARA,SOCS3,STAP1,STAT3,PRKCZ,PTPN2,HYAL2,LRRK2,LYN,CD300A,TNFAIP3"]
["GO:BP","positive regulation of CD4-positive, alpha-beta T cell activation","GO:2000516","0.0000575298647621044",38,235,6,18117,"PRKCQ,PRKCZ,NFKBID,IL18,LGALS9,CD81"]
["GO:BP","positive regulation of fatty acid metabolic process","GO:0045923","0.0000575298647621044",38,235,6,18117,"ABCD1,NR1H3,PPARA,PPARD,PPARG,PTGS2"]
["GO:BP","regulation of transmembrane transport","GO:0034762","0.00005863115639773956",588,235,22,18117,"EDNRA,APP,APPL2,SCN9A,P2RX7,PIK3CG,GJA1,C3,SNCA,STK39,PRKD1,PTAFR,IGF1,LYN,MAPK14,TCIRG1,TGFB1,THBS1,CCR2,CTSS,CX3CL1,CYBB"]
["GO:BP","negative regulation of phosphorus metabolic process","GO:0010563","0.00005901714526258831",544,235,21,18117,"MFHAS1,APOE,NUPR1,PDCD4,FABP4,GSTP1,HGF,SIRPA,SLIT2,SNCA,PPARA,SOCS3,STAP1,STAT3,PRKCZ,PTPN2,HYAL2,LRRK2,LYN,CD300A,TNFAIP3"]
["GO:BP","ossification","GO:0001503","0.00005951920018739405",417,235,18,18117,"EGFR,EPHA2,ALOX5,NOTCH1,P2RX7,HGF,PPARG,PRKD1,PTGS2,IGF1,MAPK14,RBPJ,TCIRG1,TGFB1,CEBPB,CSF1,CTNNBIP1,DHX9"]
["GO:BP","interleukin-1-mediated signaling pathway","GO:0070498","0.00005978400331314779",105,235,9,18117,"RPS6KA5,PSMA1,NFKB1,NFKBIA,IL1R1,IL1R2,IL1RAP,IRAK2,ZBP1"]
["GO:BP","cell surface receptor signaling pathway involved in cell-cell signaling","GO:1905114","0.0000628290861429439",636,235,23,18117,"EGFR,APOE,APP,SDC1,NOTCH1,P2RX1,P2RX7,GPRC5B,C3,SNCA,PRKCZ,PSMA1,NFKB1,ITGAM,LRRK2,MAPK14,RBPJ,TLR2,TNFAIP3,VPS35,CTNNBIP1,CYLD,DDX3X"]
["GO:BP","fat cell differentiation","GO:0045444","0.00006323993589187299",229,235,13,18117,"ALOX5,METRNL,RORA,FABP4,PPARD,PPARG,PTGS2,LPL,MAPK14,RARRES2,TRPV4,CEBPB,CMKLR1"]
["GO:BP","sensory perception of pain","GO:0019233","0.00006439803724105094",106,235,9,18117,"EDNRB,MGLL,SCN9A,P2RX7,PTAFR,PTGS2,LXN,CCR2,CNR2"]
["GO:BP","negative regulation of cytokine production involved in inflammatory response","GO:1900016","0.00006669043437073208",39,235,6,18117,"ABCD1,APPL2,PDCD4,SIRPA,PPARA,IL1R2"]
["GO:BP","negative regulation of cytokine-mediated signaling pathway","GO:0001960","0.00007235037390099999",82,235,8,18117,"NR1H3,GSTP1,SLIT2,PPARG,STAP1,PTPN2,IL1R2,CCL5"]
["GO:BP","regulation of leukocyte apoptotic process","GO:2000106","0.00007235037390099999",82,235,8,18117,"ADAM17,AXL,BCL6,PRKCQ,IDO1,LGALS9,LYN,CCL5"]
["GO:BP","positive regulation of small GTPase mediated signal transduction","GO:0051057","0.00007235037390099999",82,235,8,18117,"NOTCH1,NOTCH2,PIK3CG,IGF1,JAK2,LYN,RASGRP1,CSF1"]
["GO:BP","nitric oxide biosynthetic process","GO:0006809","0.00007235037390099999",82,235,8,18117,"RORA,SIRPA,PTGIS,PTGS2,ICAM1,JAK2,TLR4,CD47"]
["GO:BP","cellular macromolecule biosynthetic process","GO:0034645","0.00007277074236818465",5051,235,96,18117,"MCPH1,MECOM,EDNRB,EGFR,EIF2AK1,ELF3,AGER,AIM2,AKNA,APOE,APP,SERPINE1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ASH1L,ATM,PARP4,PDCD4,PDE2A,BCL6,C5AR1,FABP4,FANCA,FANCD2,GJA1,HAVCR2,HCK,HDAC9,HGF,SLC11A1,CAMK1D,CAMK4,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGIS,PTPN2,NDST1,NFKB1,NFKBIA,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IGF1,IL18,IL18R1,IL18RAP,IL1RAP,IL33,IRAK2,JAK2,KIT,KPNA6,LGALS9,MAPK14,RBPJ,REL,RELB,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD28,CD81,TNFAIP3,TNIP1,TRPV4,CEBPB,CIITA,CMKLR1,CSRP3,CTNNBIP1,DHX9,DICER1,CX3CL1,CYLD,DDX3X"]
["GO:BP","central nervous system development","GO:0007417","0.00007340700939201383",1032,235,31,18117,"MCPH1,EGFR,AGER,AKNA,APP,RORA,NOTCH1,ATM,ATRN,AXL,C5AR1,FANCD2,GRN,GSTP1,C3,SLIT2,PPARG,STAT3,NDST1,NDUFS4,ITGAM,LDLR,LRRK2,LYN,RBPJ,TBC1D23,TGFB1,TLR2,TLR4,TNFRSF1B,CSF1R"]
["GO:BP","regulation of metal ion transport","GO:0010959","0.00007340700939201383",268,235,14,18117,"P2RX1,P2RX7,PIK3CG,GJA1,SNCA,PRKD1,PTGS2,ICAM1,IL16,LYN,TGFB1,CCL4,CCL5,CX3CL1"]
["GO:BP","leukocyte apoptotic process","GO:0071887","0.00007429792220431806",108,235,9,18117,"ADAM17,AXL,BCL6,PRKCQ,IDO1,IL2RA,LGALS9,LYN,CCL5"]
["GO:BP","negative regulation of cellular response to insulin stimulus","GO:1900077","0.00007688513416455878",40,235,6,18117,"APPL2,SOCS3,PRKCQ,PRKCZ,PTPN2,LPL"]
["GO:BP","response to organophosphorus","GO:0046683","0.00007848290232813173",137,235,10,18117,"APP,SDC1,P2RX1,P2RX7,PDE2A,PIK3CG,PTAFR,PTGS2,NDUFS4,HSPD1"]
["GO:BP","extrinsic apoptotic signaling pathway via death domain receptors","GO:0008625","0.0000786049771177805",83,235,8,18117,"SERPINE1,HGF,HMGB2,HMOX1,ICAM1,THBS1,TNFAIP3,DDX3X"]
["GO:BP","positive regulation of interferon-alpha production","GO:0032727","0.00007871078437019123",24,235,5,18117,"HMGB1,HSPD1,TLR4,DHX9,DDX3X"]
["GO:BP","cellular response to low-density lipoprotein particle stimulus","GO:0071404","0.00007871078437019123",24,235,5,18117,"FCER1G,PPARG,LDLR,LPL,CD81"]
["GO:BP","dendritic cell chemotaxis","GO:0002407","0.00007871078437019123",24,235,5,18117,"PIK3CG,HMGB1,LGALS9,CCL5,CCR2"]
["GO:BP","regulation of lipopolysaccharide-mediated signaling pathway","GO:0031664","0.00007871078437019123",24,235,5,18117,"PRKCA,LY86,LY96,TNFAIP3,CX3CL1"]
["GO:BP","positive regulation of cytokine production involved in inflammatory response","GO:1900017","0.00007871078437019123",24,235,5,18117,"GBP5,STAT3,KPNA6,TLR4,CD6"]
["GO:BP","detection of molecule of bacterial origin","GO:0032490","0.00008060093414909925",12,235,4,18117,"LY96,TLR1,TLR2,TLR4"]
["GO:BP","regulation of neutrophil activation","GO:1902563","0.00008060093414909925",12,235,4,18117,"GRN,PTAFR,ITGAM,CD300A"]
["GO:BP","regulation of dendritic cell differentiation","GO:2001198","0.00008060093414909925",12,235,4,18117,"AGER,HMGB1,LGALS9,CEBPB"]
["GO:BP","complement receptor mediated signaling pathway","GO:0002430","0.00008060093414909925",12,235,4,18117,"C5AR1,FPR1,FPR3,CMKLR1"]
["GO:BP","interleukin-2-mediated signaling pathway","GO:0038110","0.00008060093414909925",12,235,4,18117,"STAT5A,STAT5B,PTPN2,IL2RA"]
["GO:BP","positive regulation of cysteine-type endopeptidase activity involved in apoptotic process","GO:0043280","0.00008263142623455926",138,235,10,18117,"P2RX1,F3,SNCA,PPARG,HMGB1,HSPD1,JAK2,LGALS9,UACA,DDX3X"]
["GO:BP","multi-organism reproductive process","GO:0044703","0.00008402153130094444",1040,235,31,18117,"EDNRB,ACE,APP,NOTCH1,P2RX1,ASH1L,ATM,AXL,BCL6,FANCA,FANCD2,GJA1,GPX4,HAVCR2,PPARD,STAT3,STAT5B,PTAFR,PTGFR,PTGS2,HMGB2,IDO1,IGF1,JAM3,KIT,KPNA6,LGALS9,LRRK2,TGFB1,TIMP1,DDX3X"]
["GO:BP","myoblast differentiation","GO:0045445","0.00008477063959283256",84,235,8,18117,"SDC1,NOTCH1,PPARD,IGF1,IL18,MAPK14,RBPJ,CSRP3"]
["GO:BP","negative regulation of apoptotic signaling pathway","GO:2001234","0.00008485156655216452",236,235,13,18117,"SERPINE1,GSTP1,HGF,PTGS2,HMGB2,HMOX1,ICAM1,IGF1,LRRK2,THBS1,TNFAIP3,CX3CL1,DDX3X"]
["GO:BP","lymphocyte homeostasis","GO:0002260","0.0000865499741196218",61,235,7,18117,"STAT5B,IL2RA,LGALS9,LYN,TCIRG1,TGFB1,TNFAIP3"]
["GO:BP","modulation of chemical synaptic transmission","GO:0050804","0.00008716384010434992",430,235,18,18117,"EGFR,ABR,AGER,APOE,APP,P2RX1,BCR,SNCA,STAT3,PRKCZ,PTGS2,PXK,JAK2,KIT,LRRK2,CCR2,CNR2,CX3CL1"]
["GO:BP","regulation of natural killer cell mediated cytotoxicity","GO:0042269","0.00008718444346852443",41,235,6,18117,"SERPINB9,HAVCR2,STAT5B,IL18RAP,LGALS9,RASGRP1"]
["GO:BP","regulation of triglyceride metabolic process","GO:0090207","0.00008718444346852443",41,235,6,18117,"APOE,NR1H3,PIK3CG,C3,LDLR,DAGLB"]
["GO:BP","semi-lunar valve development","GO:1905314","0.00008718444346852443",41,235,6,18117,"NOTCH1,NOTCH2,SLIT2,RBPJ,TGFB1,TNFRSF1B"]
["GO:BP","response to reactive oxygen species","GO:0000302","0.00008821471294049916",237,235,13,18117,"EGFR,APOE,SDC1,AXL,GSTP1,HGF,SIRPA,HMOX1,HSPD1,HYAL2,IL18RAP,LRRK2,TNFAIP3"]
["GO:BP","regulation of trans-synaptic signaling","GO:0099177","0.00008946668120685728",431,235,18,18117,"EGFR,ABR,AGER,APOE,APP,P2RX1,BCR,SNCA,STAT3,PRKCZ,PTGS2,PXK,JAK2,KIT,LRRK2,CCR2,CNR2,CX3CL1"]
["GO:BP","B cell differentiation","GO:0030183","0.00009269732528612064",140,235,10,18117,"ADAM17,NOTCH2,ATM,BCL6,HDAC9,STAT5B,PTPN2,KIT,RBPJ,TCIRG1"]
["GO:BP","cellular catabolic process","GO:0044248","0.0000982151083641177",2347,235,54,18117,"ENPP3,ABCD1,ABHD12,ACE,ACER3,ADAMTS12,MGLL,APOE,APP,AOAH,RPS19,NUPR1,P2RX7,ATM,PDE2A,PDE5A,PIK3CG,FABP4,HGF,SLC11A1,PLA2G4A,PLA2G7,SNCA,PPARA,PPARD,STAT3,PRKCA,PRKD1,PSMA1,HMGB1,HMGB2,HMOX1,IDO1,IGF1,IL33,LDLR,LPL,LRRK2,MAPK14,MAPKAPK2,TCIRG1,TIMP1,CD81,TNFAIP3,TNFRSF1B,VPS35,CTSC,CTSS,DHX9,DICER1,CYLD,DAGLB,DNASE1,DROSHA"]
["GO:BP","import into nucleus","GO:0051170","0.00009859676954263062",172,235,11,18117,"APPL2,STAT3,PRKD1,PTGS2,NFKBIA,HYAL2,JAK2,KPNA6,LRRK2,MAPK14,TGFB1"]
["GO:BP","negative regulation of reactive oxygen species biosynthetic process","GO:1903427","0.00009990575422826648",42,235,6,18117,"ABCD1,SIRPA,PPARA,STAT3,PTGIS,HSPD1"]
["GO:BP","positive regulation of glial cell differentiation","GO:0045687","0.00009990575422826648",42,235,6,18117,"NOTCH1,PPARG,TGFB1,TLR2,TNFRSF1B,DICER1"]
["GO:BP","triglyceride metabolic process","GO:0006641","0.00010396306670040684",113,235,9,18117,"MGLL,APOE,NR1H3,PIK3CG,FABP4,C3,LDLR,LPL,DAGLB"]
["GO:BP","heart valve development","GO:0003170","0.00010585423942127883",63,235,7,18117,"NOTCH1,NOTCH2,PDE2A,SLIT2,RBPJ,TGFB1,TNFRSF1B"]
["GO:BP","lymphocyte chemotaxis","GO:0048247","0.00010585423942127883",63,235,7,18117,"ADAM17,PIK3CG,STK39,CCL4,CCL5,CCR2,CX3CL1"]
["GO:BP","chemokine-mediated signaling pathway","GO:0070098","0.00010801017437189997",87,235,8,18117,"SLIT2,STK39,CCL4,CCL5,CCR2,CMKLR1,CX3CL1,CXCL2"]
["GO:BP","positive regulation of membrane invagination","GO:1905155","0.00011223116831392226",13,235,4,18117,"APPL2,C3,PPARG,STAP1"]
["GO:BP","cellular response to interleukin-2","GO:0071352","0.00011223116831392226",13,235,4,18117,"STAT5A,STAT5B,PTPN2,IL2RA"]
["GO:BP","respiratory burst involved in defense response","GO:0002679","0.00011223116831392226",13,235,4,18117,"RPS19,PIK3CG,GRN,HCK"]
["GO:BP","macrophage proliferation","GO:0061517","0.00011223116831392226",13,235,4,18117,"IL33,CSF1,CSF1R,CX3CL1"]
["GO:BP","negative regulation of macrophage derived foam cell differentiation","GO:0010745","0.00011223116831392226",13,235,4,18117,"NR1H3,PPARA,PPARG,NFKBIA"]
["GO:BP","positive regulation of phagocytosis, engulfment","GO:0060100","0.00011223116831392226",13,235,4,18117,"APPL2,C3,PPARG,STAP1"]
["GO:BP","response to toxic substance","GO:0009636","0.00011302458867206661",243,235,13,18117,"ALOX5AP,APOE,SCN9A,SDC1,NUPR1,GPX4,GSTP1,PTGS1,PTGS2,LYN,TLR2,CCL4,CCL5"]
["GO:BP","regulation of lymphocyte chemotaxis","GO:1901623","0.0001148590648134862",26,235,5,18117,"ADAM17,STK39,CCL4,CCL5,CCR2"]
["GO:BP","regulation of response to interferon-gamma","GO:0060330","0.0001148590648134862",26,235,5,18117,"NR1H3,PPARG,SOCS3,PTPN2,JAK2"]
["GO:BP","myeloid leukocyte cytokine production","GO:0061082","0.0001148590648134862",26,235,5,18117,"BCL6,GPRC5B,HMOX1,KIT,TLR4"]
["GO:BP","growth hormone receptor signaling pathway","GO:0060396","0.0001148590648134862",26,235,5,18117,"STAT3,STAT5A,STAT5B,JAK2,LYN"]
["GO:BP","regulation of interferon-gamma-mediated signaling pathway","GO:0060334","0.0001148590648134862",26,235,5,18117,"NR1H3,PPARG,SOCS3,PTPN2,JAK2"]
["GO:BP","negative regulation of response to cytokine stimulus","GO:0060761","0.000115744420200955",88,235,8,18117,"NR1H3,GSTP1,SLIT2,PPARG,STAP1,PTPN2,IL1R2,CCL5"]
["GO:BP","defense response to Gram-negative bacterium","GO:0050829","0.000115744420200955",88,235,8,18117,"SERPINE1,RPS19,SLC11A1,PRKD1,HMGB2,RARRES2,TLR4,DROSHA"]
["GO:BP","regulation of vasoconstriction","GO:0019229","0.000115744420200955",64,235,7,18117,"EGFR,ACE,P2RX1,GJA1,PTAFR,PTGS2,ICAM1"]
["GO:BP","negative regulation of cellular component organization","GO:0051129","0.00011727526002111502",759,235,25,18117,"ACE,APOE,NOTCH1,NR1H3,NUPR1,ATM,HGF,SLIT2,SNCA,STAP1,PRKCZ,PRKD1,HMGB1,IGF1,JAM3,LDLR,LRRK2,THBS1,TLR2,CD300A,CDH5,TNFRSF1B,TRPV4,CTNNBIP1,DDX3X"]
["GO:BP","female sex differentiation","GO:0046660","0.00011736587261111241",115,235,9,18117,"NUPR1,ATM,AXL,FANCA,SLIT2,STAT5B,ICAM1,KIT,CEBPB"]
["GO:BP","regulation of carbohydrate metabolic process","GO:0006109","0.0001228779789141295",210,235,12,18117,"APP,RORA,NUPR1,P2RX7,SNCA,PPARA,STAT3,PTAFR,PTPN2,NFKB1,HMGB1,IGF1"]
["GO:BP","extracellular matrix organization","GO:0030198","0.00012510166163553482",401,235,17,18117,"ELF3,ABI3BP,ADAMTS12,APP,SERPINE1,NOTCH1,FN1,ICAM1,ITGAM,ITGB6,JAM3,TGFB1,THBS1,TIMP1,CD47,TNFRSF1B,CTSS"]
["GO:BP","tumor necrosis factor-mediated signaling pathway","GO:0033209","0.0001252080128788885",177,235,11,18117,"ADAM17,AIM2,GSTP1,CASP4,PSMA1,PTPN2,NFKBIA,JAK2,TNFAIP3,TNFRSF1B,CYLD"]
["GO:BP","movement in host environment","GO:0052126","0.0001252080128788885",177,235,11,18117,"EGFR,EPHA2,AXL,SLAMF1,HYAL2,ICAM1,ITGB6,LDLR,LGALS9,CD81,CIITA"]
["GO:BP","regulation of nervous system development","GO:0051960","0.0001252080128788885",443,235,18,18117,"APPL2,SERPINF1,NOTCH1,FN1,HGF,SLIT2,PPARG,HMGB2,IL1RAP,KIT,LDLR,LYN,TGFB1,TLR2,TNFRSF1B,CTSC,DICER1,CX3CL1"]
["GO:BP","neuron projection development","GO:0031175","0.0001252080128788885",1012,235,30,18117,"EGFR,EPHA2,AGER,APOE,APP,SERPINF1,RPS6KA5,NOTCH1,NOTCH2,FN1,GJA1,GRN,HGF,SLIT2,CAMK1D,PRKCA,PRKCQ,PRKCZ,PRKD1,HMGB1,JAK2,JAM3,LRRK2,LYN,TBC1D23,TRPV4,ULK4,CSF1R,DICER1,CX3CL1"]
["GO:BP","response to inorganic substance","GO:0010035","0.00012578516994171942",575,235,21,18117,"EGFR,ALOX5AP,APP,SDC1,SERPINF1,AXL,FABP4,HGF,SIRPA,SNCA,PTGS2,HMOX1,HSPD1,ICAM1,IL18RAP,KIT,LRRK2,TCIRG1,THBS1,TNFAIP3,CYBB"]
["GO:BP","regulation of multicellular organism growth","GO:0040014","0.0001268398412104845",65,235,7,18117,"APP,ATRN,STAT3,STAT5A,STAT5B,IGF1,CSF1"]
["GO:BP","maternal process involved in female pregnancy","GO:0060135","0.0001268398412104845",65,235,7,18117,"ASH1L,GJA1,HAVCR2,PPARD,PTGS2,KPNA6,LGALS9"]
["GO:BP","positive regulation of ATP metabolic process","GO:1903580","0.00012755074217114213",44,235,6,18117,"APP,NUPR1,P2RX7,PPARA,STAT3,IGF1"]
["GO:BP","extracellular structure organization","GO:0043062","0.0001279946851885871",402,235,17,18117,"ELF3,ABI3BP,ADAMTS12,APP,SERPINE1,NOTCH1,FN1,ICAM1,ITGAM,ITGB6,JAM3,TGFB1,THBS1,TIMP1,CD47,TNFRSF1B,CTSS"]
["GO:BP","positive regulation of T-helper 1 cell cytokine production","GO:2000556","0.00012833859789898052",5,235,3,18117,"IL18,IL18R1,IL1R1"]
["GO:BP","mast cell proliferation","GO:0070662","0.00012833859789898052",5,235,3,18117,"ENPP3,KIT,LYN"]
["GO:BP","regulation of T-helper 1 cell cytokine production","GO:2000554","0.00012833859789898052",5,235,3,18117,"IL18,IL18R1,IL1R1"]
["GO:BP","T-helper 1 cell cytokine production","GO:0035744","0.00012833859789898052",5,235,3,18117,"IL18,IL18R1,IL1R1"]
["GO:BP","regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell","GO:2001188","0.00012833859789898052",5,235,3,18117,"HAVCR2,LGALS9,CD81"]
["GO:BP","intracellular receptor signaling pathway","GO:0030522","0.00013107733789840045",284,235,14,18117,"RORA,NR1H3,PPARA,PPARD,PPARG,STAT3,PRCP,PTGIS,NFKBIA,IRAK2,JAK2,TLR4,TNFAIP3,CYLD"]
["GO:BP","regulation of endocytosis","GO:0030100","0.00013276173652240926",212,235,12,18117,"APOE,APPL2,SERPINE1,NR1H3,AXL,C3,SNCA,PPARG,STAP1,PRKD1,LRRK2,CD300A"]
["GO:BP","external encapsulating structure organization","GO:0045229","0.00013527604721533617",404,235,17,18117,"ELF3,ABI3BP,ADAMTS12,APP,SERPINE1,NOTCH1,FN1,ICAM1,ITGAM,ITGB6,JAM3,TGFB1,THBS1,TIMP1,CD47,TNFRSF1B,CTSS"]
["GO:BP","placenta development","GO:0001890","0.0001354445116099681",147,235,10,18117,"NOTCH2,ASH1L,GJA1,PPARD,PPARG,SOCS3,PTGS2,MAPK14,RBPJ,CEBPB"]
["GO:BP","regulation of nervous system process","GO:0031644","0.0001354445116099681",147,235,10,18117,"EDNRB,MGLL,APP,HGF,PRKCZ,PTAFR,LRRK2,TNFRSF1B,CTSC,DICER1"]
["GO:BP","cellular response to growth hormone stimulus","GO:0071378","0.00013568831392473047",27,235,5,18117,"STAT3,STAT5A,STAT5B,JAK2,LYN"]
["GO:BP","glucose homeostasis","GO:0042593","0.00013568831392473047",248,235,13,18117,"AGER,ALOX5,APPL2,SERPINF1,PPARD,PPARG,STAT3,PRCP,PTPN2,ICAM1,TRPV4,CSRP3,HK1"]
["GO:BP","growth","GO:0040007","0.0001381168911811301",967,235,29,18117,"EGFR,ADAM17,APOE,APP,NOTCH1,NOTCH2,ATM,ATRN,BCL6,FN1,GJA1,SLIT2,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PRKCZ,HYAL2,IGF1,MAPK14,RBPJ,TGFB1,CD81,CSF1,DDX3X"]
["GO:BP","positive regulation of gliogenesis","GO:0014015","0.00013816241051562133",66,235,7,18117,"NOTCH1,PPARG,LYN,TGFB1,TLR2,TNFRSF1B,DICER1"]
["GO:BP","carbohydrate homeostasis","GO:0033500","0.00014101081785325412",249,235,13,18117,"AGER,ALOX5,APPL2,SERPINF1,PPARD,PPARG,STAT3,PRCP,PTPN2,ICAM1,TRPV4,CSRP3,HK1"]
["GO:BP","neural precursor cell proliferation","GO:0061351","0.0001427979021914281",148,235,10,18117,"AKNA,APPL2,RORA,NOTCH1,C5AR1,LRRK2,LYN,TGFB1,CX3CL1,DAGLB"]
["GO:BP","regulation of vascular permeability","GO:0043114","0.00014303305347447906",45,235,6,18117,"APOE,PDE2A,SLIT2,CDH5,TRPV4,CTNNBIP1"]
["GO:BP","regulation of binding","GO:0051098","0.00014303305347447906",365,235,16,18117,"ACE,AGER,APOE,APP,PPARA,PPARG,NFKBIA,HMGB1,HMGB2,HMOX1,IGF1,JAK2,LRRK2,TGFB1,CTNNBIP1,DHX9"]
["GO:BP","animal organ morphogenesis","GO:0009887","0.00014432091992372522",1073,235,31,18117,"ELF3,EPHA2,SDC1,SERPINE1,NOTCH1,NOTCH2,ASH1L,ATRN,PDCD4,FANCD2,FGFR1,HGF,SLIT2,PPARA,STAT3,PSMA1,NDST1,HYAL2,ITGB6,LRRK2,MAPK14,RBPJ,TCIRG1,TGFB1,TGM2,TNFAIP3,TRPV4,CEBPB,CSF1,CSF1R,CTNNBIP1"]
["GO:BP","cell junction organization","GO:0034330","0.00014533654647505087",722,235,24,18117,"EPHA2,ACE,APOE,APP,BCR,C5AR1,FN1,GJA1,C3,SNCA,PRKCA,IL1RAP,ITGAM,JAM3,LRFN5,LRRK2,MAPK14,THBS1,TLR2,CDH5,TRPV4,VPS35,CSF1R,CX3CL1"]
["GO:BP","response to interleukin-2","GO:0070669","0.0001488031254429034",14,235,4,18117,"STAT5A,STAT5B,PTPN2,IL2RA"]
["GO:BP","germinal center formation","GO:0002467","0.0001488031254429034",14,235,4,18117,"ADAM17,BCL6,TNFAIP3,UNC13D"]
["GO:BP","positive regulation of monocyte chemotactic protein-1 production","GO:0071639","0.0001488031254429034",14,235,4,18117,"AGER,HMGB1,LGALS9,TRPV4"]
["GO:BP","regulation of ion transmembrane transport","GO:0034765","0.00015002279980587743",583,235,21,18117,"EDNRA,APP,APPL2,SCN9A,P2RX7,PIK3CG,C3,SNCA,STK39,PRKD1,PTAFR,IGF1,LYN,MAPK14,TCIRG1,TGFB1,THBS1,CCR2,CTSS,CX3CL1,CYBB"]
["GO:BP","negative regulation of neuron apoptotic process","GO:0043524","0.00015896599924626826",150,235,10,18117,"APOE,AXL,C5AR1,GRN,SNCA,HMOX1,HSPD1,JAK2,CEBPB,CX3CL1"]
["GO:BP","T cell chemotaxis","GO:0010818","0.00016057529196208736",28,235,5,18117,"ADAM17,PIK3CG,STK39,CCL5,CCR2"]
["GO:BP","positive regulation of vascular endothelial growth factor production","GO:0010575","0.00016057529196208736",28,235,5,18117,"RORA,C5AR1,C3,PTGS2,CXCL17"]
["GO:BP","regulation of p38MAPK cascade","GO:1900744","0.00016057529196208736",46,235,6,18117,"AGER,MFHAS1,HGF,PJA2,ULK4,CYLD"]
["GO:BP","negative regulation of type I interferon production","GO:0032480","0.00016057529196208736",46,235,6,18117,"HAVCR2,SIRPA,REL,RELB,TNFAIP3,CYLD"]
["GO:BP","positive regulation of phospholipase C activity","GO:0010863","0.00016057529196208736",46,235,6,18117,"EDNRA,EGFR,C5AR1,FGFR1,PTAFR,KIT"]
["GO:BP","negative regulation of toll-like receptor signaling pathway","GO:0034122","0.00016057529196208736",46,235,6,18117,"MFHAS1,LY96,LYN,TLR4,CD300A,TNFAIP3"]
["GO:BP","regulation of nitric oxide biosynthetic process","GO:0045428","0.00016536427147087148",68,235,7,18117,"SIRPA,PTGIS,PTGS2,ICAM1,JAK2,TLR4,CD47"]
["GO:BP","positive regulation of stress-activated MAPK cascade","GO:0032874","0.00016890934835285588",121,235,9,18117,"AGER,MFHAS1,APP,SLAMF1,PJA2,HMGB1,RASGRP1,TLR4,TRPV4"]
["GO:BP","negative regulation of leukocyte migration","GO:0002686","0.00018140260997337828",47,235,6,18117,"SLIT2,STAP1,HMOX1,IL33,CD200,CD300A"]
["GO:BP","negative regulation of cold-induced thermogenesis","GO:0120163","0.00018140260997337828",47,235,6,18117,"ADAM17,NOTCH1,NR1H3,IL18R1,RBPJ,TLR4"]
["GO:BP","negative regulation of protein phosphorylation","GO:0001933","0.0001827944318491483",373,235,16,18117,"APOE,PDCD4,FABP4,GSTP1,HGF,SIRPA,SLIT2,SNCA,SOCS3,PRKCZ,PTPN2,HYAL2,LRRK2,LYN,CD300A,TNFAIP3"]
["GO:BP","regulation of viral life cycle","GO:1903900","0.00018617143614654296",153,235,10,18117,"NOTCH1,AXL,PPARA,KPNA6,LGALS9,CCL5,CD28,TNIP1,CIITA,DDX3X"]
["GO:BP","intrinsic apoptotic signaling pathway","GO:0097193","0.00018617143614654296",294,235,14,18117,"EPHA2,NUPR1,ATM,SGMS1,CASP4,PTGS2,PTPN2,HMOX1,JAK2,LRRK2,TNFRSF1B,CEBPB,CYLD,DDX3X"]
["GO:BP","learning or memory","GO:0007611","0.00019169141858098229",257,235,13,18117,"EGFR,AGER,APOE,APP,SERPINF1,CAMK4,PJA2,PRKCZ,PTGS2,KIT,LDLR,TLR2,CEBPB"]
["GO:BP","regulation of protein secretion","GO:0050708","0.00019283529658452303",295,235,14,18117,"EGFR,ALOX5,APOE,NR1H3,GJA1,PPARD,PRKCA,IGF1,JAK2,TCIRG1,TLR2,TLR4,CCL5,CD200"]
["GO:BP","positive regulation of fatty acid oxidation","GO:0046321","0.0001972509826587454",15,235,4,18117,"ABCD1,PPARA,PPARD,PPARG"]
["GO:BP","CD40 signaling pathway","GO:0023035","0.0001972509826587454",15,235,4,18117,"FANCA,FANCD2,SLAMF1,TNFAIP3"]
["GO:BP","negative regulation of T cell proliferation","GO:0042130","0.00019759425032973707",70,235,7,18117,"HAVCR2,SPN,IDO1,IL2RA,LGALS9,TGFB1,CEBPB"]
["GO:BP","regulation of nitric oxide metabolic process","GO:0080164","0.00019759425032973707",70,235,7,18117,"SIRPA,PTGIS,PTGS2,ICAM1,JAK2,TLR4,CD47"]
["GO:BP","negative regulation of smooth muscle cell proliferation","GO:0048662","0.00019759425032973707",70,235,7,18117,"PDCD4,GSTP1,PPARD,PPARG,HMOX1,TNFAIP3,CTNNBIP1"]
["GO:BP","positive regulation of T cell mediated immunity","GO:0002711","0.00020201833907295484",48,235,6,18117,"PRKCZ,HSPD1,IL18,IL18R1,IL1R1,CD81"]
["GO:BP","regulation of phospholipase C activity","GO:1900274","0.00020201833907295484",48,235,6,18117,"EDNRA,EGFR,C5AR1,FGFR1,PTAFR,KIT"]
["GO:BP","acylglycerol catabolic process","GO:0046464","0.00020201833907295484",48,235,6,18117,"ABHD12,MGLL,PIK3CG,FABP4,LPL,DAGLB"]
["GO:BP","response to cold","GO:0009409","0.00020201833907295484",48,235,6,18117,"METRNL,APPL2,PPARG,NFKBIA,HSPD1,LPL"]
["GO:BP","neutral lipid catabolic process","GO:0046461","0.00020201833907295484",48,235,6,18117,"ABHD12,MGLL,PIK3CG,FABP4,LPL,DAGLB"]
["GO:BP","regulation of cell adhesion mediated by integrin","GO:0033628","0.00020201833907295484",48,235,6,18117,"EPHA2,SERPINE1,PIK3CG,JAM3,LYN,CCL5"]
["GO:BP","female gonad development","GO:0008585","0.00020520283063186524",96,235,8,18117,"NUPR1,ATM,FANCA,SLIT2,STAT5B,ICAM1,KIT,CEBPB"]
["GO:BP","neuron development","GO:0048666","0.00020898068033320524",1149,235,32,18117,"EDNRB,EGFR,EPHA2,AGER,APOE,APP,SERPINF1,RPS6KA5,NOTCH1,NOTCH2,FN1,GJA1,GRN,HGF,C3,SLIT2,CAMK1D,PRKCA,PRKCQ,PRKCZ,PRKD1,HMGB1,JAK2,JAM3,LRRK2,LYN,TBC1D23,TRPV4,ULK4,CSF1R,DICER1,CX3CL1"]
["GO:BP","cognition","GO:0050890","0.00021257392126983876",298,235,14,18117,"EGFR,AGER,APOE,APP,SERPINF1,C5AR1,CAMK4,PJA2,PRKCZ,PTGS2,KIT,LDLR,TLR2,CEBPB"]
["GO:BP","response to chemokine","GO:1990868","0.00022015022241338305",97,235,8,18117,"SLIT2,STK39,CCL4,CCL5,CCR2,CMKLR1,CX3CL1,CXCL2"]
["GO:BP","positive regulation of cold-induced thermogenesis","GO:0120162","0.00022015022241338305",97,235,8,18117,"APPL2,FABP4,GJA1,IL18,JAK2,CCR2,CEBPB,CMKLR1"]
["GO:BP","cellular response to chemokine","GO:1990869","0.00022015022241338305",97,235,8,18117,"SLIT2,STK39,CCL4,CCL5,CCR2,CMKLR1,CX3CL1,CXCL2"]
["GO:BP","regulation of mast cell degranulation","GO:0043304","0.0002221212006986316",30,235,5,18117,"HMOX1,LGALS9,LYN,CD300A,UNC13D"]
["GO:BP","brown fat cell differentiation","GO:0050873","0.00022604038395142436",49,235,6,18117,"METRNL,FABP4,PTGS2,MAPK14,TRPV4,CEBPB"]
["GO:BP","regulation of developmental growth","GO:0048638","0.00023019973403345687",340,235,15,18117,"APOE,APP,NOTCH1,ATRN,FN1,GJA1,PPARA,PPARD,STAT3,STAT5A,STAT5B,IGF1,MAPK14,RBPJ,CSF1"]
["GO:BP","regulation of glial cell differentiation","GO:0045685","0.0002340174767205943",72,235,7,18117,"NOTCH1,PPARG,LDLR,TGFB1,TLR2,TNFRSF1B,DICER1"]
["GO:BP","B cell proliferation","GO:0042100","0.00023597539716974222",98,235,8,18117,"ATM,BCL6,HSPD1,LYN,RASGRP1,TLR4,CD300A,CD81"]
["GO:BP","positive regulation of organelle organization","GO:0010638","0.00023626991213413786",603,235,21,18117,"SDC1,RPS6KA5,P2RX7,ATM,BCL6,GRN,HCK,SNCA,STAP1,PRKCQ,PRKD1,ICAM1,IGF1,LRRK2,RICTOR,TGFB1,CD28,CD47,TRPV4,VPS35,CX3CL1"]
["GO:BP","negative regulation of mast cell degranulation","GO:0043305","0.00023946731926660782",6,235,3,18117,"HMOX1,LGALS9,CD300A"]
["GO:BP","nucleotide-binding oligomerization domain containing 1 signaling pathway","GO:0070427","0.00023946731926660782",6,235,3,18117,"NFKBIA,TLR4,TNFAIP3"]
["GO:BP","microglia differentiation","GO:0014004","0.00023946731926660782",6,235,3,18117,"APP,TGFB1,TLR2"]
["GO:BP","mast cell cytokine production","GO:0032762","0.00023946731926660782",6,235,3,18117,"BCL6,HMOX1,KIT"]
["GO:BP","negative regulation of toll-like receptor 2 signaling pathway","GO:0034136","0.00023946731926660782",6,235,3,18117,"MFHAS1,LYN,TNFAIP3"]
["GO:BP","positive regulation of cell development","GO:0010720","0.00024239323212376306",302,235,14,18117,"SERPINF1,NOTCH1,FN1,SLIT2,PPARG,KIT,LYN,TGFB1,TLR2,CDH5,TNFRSF1B,UNC13D,DICER1,CX3CL1"]
["GO:BP","regulation of viral process","GO:0050792","0.00024685004515318464",192,235,11,18117,"NOTCH1,AXL,PPARA,KPNA6,LGALS9,CCL5,CD28,TNIP1,CIITA,DHX9,DDX3X"]
["GO:BP","cellular process","GO:0009987","0.0002489964191170659",17171,235,234,18117,"MCPH1,MECOM,EDNRA,EDNRB,EGFR,EIF2AK1,ELF3,ENPP3,EPHA2,ABCC1,ABCD1,ABHD12,ABI3BP,ABR,ACE,ACER3,ADAM17,ADAMTS12,AGER,AIM2,AK7,AKNA,ALDH2,ALOX5,ALOX5AP,METRNL,MFHAS1,MGLL,APOE,APP,APPL2,AOAH,MS4A2,SCN9A,SCNN1B,SDC1,SERPINB9,SERPINE1,SERPINF1,RORA,RPS19,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,OLR1,P2RX1,P2RX7,ASH1L,ATM,ATRN,AXL,PARP4,PDCD4,PDE2A,PDE5A,PIK3AP1,PIK3CG,BCL6,BCR,SGMS1,C5AR1,F3,F8,FABP4,FANCA,FANCD2,FCER1G,FGFR1,FN1,FPR1,FPR3,GBP5,GJA1,GPRC5B,GPX4,GRN,GSTP1,HAVCR2,HCK,HDAC9,HGF,C3,SIRPA,SLAMF1,SLC11A1,SLC7A2,SLIT2,CALCRL,CAMK1D,CAMK4,CASP4,PJA2,PLA2G4A,PLA2G7,PLD3,PMP22,SNAP23,SNCA,PPARA,PPARD,PPARG,SOCS3,SPN,STAB1,STAP1,STAT3,STAT5A,STAT5B,STK39,PRCP,PRKCA,PRKCQ,PRKCZ,PRKD1,PSMA1,PTAFR,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2,PTPN2,PXK,NDST1,NDUFS4,NFKB1,NFKBIA,NFKBID,HMGB1,HMGB2,HMOX1,HSPD1,HYAL2,ICAM1,IDO1,IGF1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,ITGB6,JAK2,JAM3,KIT,KPNA6,LDLR,LGALS9,LIPA,LPCAT3,LPL,LRFN5,LRRK2,LXN,LY86,LY96,LYN,MAPK14,MAPKAPK2,RARRES2,RASGRP1,RBPJ,REL,RELB,RICTOR,TBC1D23,TCIRG1,TGFB1,TGM2,THBS1,THEMIS2,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD163,CD200,CD28,CD300A,CD47,CD6,CD68,CD81,CD96,CDH5,CDK19,TNFAIP3,TNFRSF1B,TNIP1,TRPV4,UACA,ULK4,UNC13D,VPS35,ZBP1,CEBPB,CERS6,CFH,CIITA,CMKLR1,CNR2,CSF1,CSF1R,CSRP3,CTNNBIP1,CTSC,CTSS,DHX9,DICER1,CX3CL1,CXCL17,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB,DDX3X,DNASE1,DROSHA,DUOXA1,HK1"]
["GO:BP","regulation of multi-organism process","GO:0043900","0.00025038337196190764",50,235,6,18117,"EDNRB,PRKCA,LY86,LY96,TNFAIP3,CX3CL1"]
["GO:BP","positive regulation of cytokine-mediated signaling pathway","GO:0001961","0.00025038337196190764",50,235,6,18117,"ADAM17,AXL,CASP4,IL1R1,ZBP1,CSF1"]
["GO:BP","prostanoid metabolic process","GO:0006692","0.00025038337196190764",50,235,6,18117,"GSTP1,PLA2G4A,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","prostaglandin metabolic process","GO:0006693","0.00025038337196190764",50,235,6,18117,"GSTP1,PLA2G4A,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","cholesterol homeostasis","GO:0042632","0.00025063797165328285",99,235,8,18117,"APOE,RORA,NR1H3,FABP4,HDAC9,IL18,LDLR,LPL"]
["GO:BP","lipoprotein catabolic process","GO:0042159","0.00025109122366484847",16,235,4,18117,"ABHD12,APOE,ATM,LDLR"]
["GO:BP","positive regulation of T cell chemotaxis","GO:0010820","0.00025109122366484847",16,235,4,18117,"ADAM17,STK39,CCL5,CCR2"]
["GO:BP","lipoxygenase pathway","GO:0019372","0.00025109122366484847",16,235,4,18117,"ALOX5,ALOX5AP,GPX4,PTGS2"]
["GO:BP","NLRP3 inflammasome complex assembly","GO:0044546","0.00025109122366484847",16,235,4,18117,"AIM2,GBP5,TLR4,DDX3X"]
["GO:BP","regulation of MHC class II biosynthetic process","GO:0045346","0.00025109122366484847",16,235,4,18117,"IL33,JAK2,TLR4,CIITA"]
["GO:BP","positive regulation of viral genome replication","GO:0045070","0.000256335433549371",31,235,5,18117,"NOTCH1,PPARA,CCL5,CD28,DDX3X"]
["GO:BP","positive regulation of neurogenesis","GO:0050769","0.0002633427095641452",229,235,12,18117,"SERPINF1,NOTCH1,FN1,SLIT2,PPARG,KIT,LYN,TGFB1,TLR2,TNFRSF1B,DICER1,CX3CL1"]
["GO:BP","cell projection organization","GO:0030030","0.0002643551760087585",1609,235,40,18117,"EGFR,EPHA2,ABCD1,AGER,AK7,APOE,APP,SERPINF1,RPS6KA5,NOTCH1,NOTCH2,P2RX7,FN1,GJA1,GRN,HGF,SLIT2,CAMK1D,PMP22,STAP1,PRKCA,PRKCQ,PRKCZ,PRKD1,HMGB1,ICAM1,JAK2,JAM3,KIT,LRRK2,LYN,TBC1D23,TCIRG1,TRPV4,ULK4,VPS35,CSF1R,DICER1,CX3CL1,CYLD"]
["GO:BP","lymphocyte apoptotic process","GO:0070227","0.0002735884112849039",74,235,7,18117,"BCL6,PRKCQ,IDO1,IL2RA,LGALS9,LYN,CCL5"]
["GO:BP","unsaturated fatty acid biosynthetic process","GO:0006636","0.00027766975412021644",51,235,6,18117,"ABCD1,PLA2G4A,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","regulation of CD4-positive, alpha-beta T cell differentiation","GO:0043370","0.00027766975412021644",51,235,6,18117,"BCL6,PRKCZ,NFKBID,HMGB1,IL18,LGALS9"]
["GO:BP","morphogenesis of a branching structure","GO:0001763","0.0002796523429408722",195,235,11,18117,"EDNRA,EPHA2,NOTCH1,HGF,SLIT2,SOCS3,LRRK2,TGFB1,TGM2,CSF1,CTNNBIP1"]
["GO:BP","defense response to Gram-positive bacterium","GO:0050830","0.00028545970337793994",101,235,8,18117,"EPHA2,ADAM17,C5AR1,HAVCR2,HMGB2,RARRES2,TLR2,DROSHA"]
["GO:BP","development of primary female sexual characteristics","GO:0046545","0.00028545970337793994",101,235,8,18117,"NUPR1,ATM,FANCA,SLIT2,STAT5B,ICAM1,KIT,CEBPB"]
["GO:BP","regulation of gliogenesis","GO:0014013","0.00028545970337793994",101,235,8,18117,"NOTCH1,PPARG,LDLR,LYN,TGFB1,TLR2,TNFRSF1B,DICER1"]
["GO:BP","long-chain fatty acid transport","GO:0015909","0.00029657703499162154",75,235,7,18117,"ABCD1,ACE,APOE,FABP4,PLA2G4A,PPARG,THBS1"]
["GO:BP","prostanoid biosynthetic process","GO:0046457","0.0002971011708446436",32,235,5,18117,"PLA2G4A,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","prostaglandin biosynthetic process","GO:0001516","0.0002971011708446436",32,235,5,18117,"PLA2G4A,PTGIS,PTGS1,PTGS2,DAGLB"]
["GO:BP","angiogenesis involved in wound healing","GO:0060055","0.0002971011708446436",32,235,5,18117,"ALOX5,SERPINE1,PRCP,TNFAIP3,CX3CL1"]
["GO:BP","apoptotic cell clearance","GO:0043277","0.0003080063642923826",52,235,6,18117,"NR1H3,AXL,C3,HMGB1,TGM2,THBS1"]
["GO:BP","biomineral tissue development","GO:0031214","0.00031801121749339795",164,235,10,18117,"ALOX5,NOTCH1,P2RX7,PPARA,PTGS2,IGF1,ITGB6,TCIRG1,TGFB1,CEBPB"]
["GO:BP","regulation of generation of precursor metabolites and energy","GO:0043467","0.00031801121749339795",164,235,10,18117,"ABCD1,APP,NUPR1,P2RX7,SNCA,PPARA,STAT3,HMGB1,IGF1,TRPV4"]
["GO:BP","female pregnancy","GO:0007565","0.00031801121749339795",198,235,11,18117,"ASH1L,GJA1,HAVCR2,PPARD,STAT5B,PTGS2,IDO1,KPNA6,LGALS9,TGFB1,TIMP1"]
["GO:BP","trans-synaptic signaling","GO:0099537","0.00031802712845680777",713,235,23,18117,"EGFR,ABR,AGER,APOE,APP,P2RX1,P2RX7,BCR,PMP22,SNAP23,SNCA,STAT3,PRKCZ,PTGS2,PXK,IL1RAP,JAK2,KIT,LRRK2,CCR2,CNR2,CX3CL1,DAGLB"]
["GO:BP","regulation of T cell chemotaxis","GO:0010819","0.00031863714290594124",17,235,4,18117,"ADAM17,STK39,CCL5,CCR2"]
["GO:BP","negative regulation of natural killer cell mediated immunity","GO:0002716","0.00031863714290594124",17,235,4,18117,"SERPINB9,HAVCR2,LGALS9,CD96"]
["GO:BP","negative regulation of interleukin-12 production","GO:0032695","0.00031863714290594124",17,235,4,18117,"SLAMF1,NFKB1,THBS1,CMKLR1"]
["GO:BP","lipid transport","GO:0006869","0.00032114976731906426",480,235,18,18117,"ABCC1,ABCD1,ACE,APOE,NR1H3,P2RX7,FABP4,GJA1,PLA2G4A,SNCA,PPARA,PPARD,PPARG,NFKB1,NFKBIA,LDLR,LPCAT3,THBS1"]
["GO:BP","calcium ion transport","GO:0006816","0.00032114976731906426",436,235,17,18117,"P2RX1,P2RX7,PIK3CG,GJA1,CALCRL,SNCA,PRKD1,PTGS2,ICAM1,IL16,LYN,TGFB1,CCL4,CCL5,TRPV4,CX3CL1,CYSLTR1"]
["GO:BP","plasma membrane bounded cell projection organization","GO:0120036","0.0003283390662949108",1569,235,39,18117,"EGFR,EPHA2,ABCD1,AGER,APOE,APP,SERPINF1,RPS6KA5,NOTCH1,NOTCH2,P2RX7,FN1,GJA1,GRN,HGF,SLIT2,CAMK1D,PMP22,STAP1,PRKCA,PRKCQ,PRKCZ,PRKD1,HMGB1,ICAM1,JAK2,JAM3,KIT,LRRK2,LYN,TBC1D23,TCIRG1,TRPV4,ULK4,VPS35,CSF1R,DICER1,CX3CL1,CYLD"]
["GO:BP","cell-matrix adhesion","GO:0007160","0.0003302847548725291",235,235,12,18117,"ADAMTS12,SERPINE1,BCL6,BCR,FN1,PRKCZ,ITGB6,JAM3,THBS1,CD96,CSF1,CX3CL1"]
["GO:BP","regulation of Ras protein signal transduction","GO:0046578","0.0003302847548725291",199,235,11,18117,"APOE,NOTCH1,NOTCH2,PIK3CG,BCL6,BCR,IGF1,JAK2,LYN,RASGRP1,CSF1"]
["GO:BP","cellular response to insulin stimulus","GO:0032869","0.0003302847548725291",235,235,12,18117,"APPL2,GSTP1,HDAC9,PPARG,SOCS3,PRKCQ,PRKCZ,PTPN2,LPL,RARRES2,TCIRG1,CSRP3"]
["GO:BP","cellular defense response","GO:0006968","0.0003393308002919174",53,235,6,18117,"C5AR1,SPN,IL33,LY96,TCIRG1,CCR2"]
["GO:BP","regulation of fatty acid oxidation","GO:0046320","0.00034126383525843936",33,235,5,18117,"ABCD1,APPL2,PPARA,PPARD,PPARG"]
["GO:BP","endothelial cell chemotaxis","GO:0035767","0.00034126383525843936",33,235,5,18117,"NOTCH1,FGFR1,PRKD1,HMGB1,THBS1"]
["GO:BP","biomineralization","GO:0110148","0.0003476364244998149",166,235,10,18117,"ALOX5,NOTCH1,P2RX7,PPARA,PTGS2,IGF1,ITGB6,TCIRG1,TGFB1,CEBPB"]
["GO:BP","positive regulation of secretion","GO:0051047","0.00035439009317587907",314,235,14,18117,"EDNRB,EGFR,SDC1,GJA1,PLA2G4A,SNCA,PPARD,PTAFR,IGF1,ITGAM,JAK2,TLR2,TLR4,UNC13D"]
["GO:BP","regulation of lipid transport","GO:0032368","0.00036499506028070866",167,235,10,18117,"APOE,NR1H3,PLA2G4A,SNCA,PPARA,PPARG,NFKB1,NFKBIA,LPCAT3,THBS1"]
["GO:BP","regulation of fatty acid metabolic process","GO:0019217","0.00036843351307776115",105,235,8,18117,"ABCD1,APPL2,NR1H3,SNCA,PPARA,PPARD,PPARG,PTGS2"]
["GO:BP","positive regulation of nervous system development","GO:0051962","0.00037132023070769743",276,235,13,18117,"SERPINF1,NOTCH1,FN1,SLIT2,PPARG,IL1RAP,KIT,LYN,TGFB1,TLR2,TNFRSF1B,DICER1,CX3CL1"]
["GO:BP","presynapse organization","GO:0099172","0.00037498771116895247",54,235,6,18117,"APP,C5AR1,SNCA,IL1RAP,LRFN5,VPS35"]
["GO:BP","regulation of biological process involved in symbiotic interaction","GO:0043903","0.00039119613775808924",203,235,11,18117,"NOTCH1,AXL,PPARA,KPNA6,LGALS9,CCL5,CD28,TNIP1,CIITA,DHX9,DDX3X"]
["GO:BP","regulation of presynapse organization","GO:0099174","0.00039174015751196404",34,235,5,18117,"APP,SNCA,IL1RAP,LRFN5,VPS35"]
["GO:BP","actin cytoskeleton reorganization","GO:0031532","0.00039174015751196404",106,235,8,18117,"NOTCH2,HCK,STAP1,KIT,RICTOR,TGFB1,TRPV4,CSF1R"]
["GO:BP","negative regulation of B cell activation","GO:0050869","0.00039174015751196404",34,235,5,18117,"ATM,BCL6,LYN,CD300A,TNFAIP3"]
["GO:BP","long-term memory","GO:0007616","0.00039174015751196404",34,235,5,18117,"APOE,CAMK4,PJA2,PRKCZ,LDLR"]
["GO:BP","regulation of presynapse assembly","GO:1905606","0.00039174015751196404",34,235,5,18117,"APP,SNCA,IL1RAP,LRFN5,VPS35"]
["GO:BP","wound healing involved in inflammatory response","GO:0002246","0.00039366277429996613",7,235,3,18117,"AGER,HMOX1,TIMP1"]
["GO:BP","negative regulation of T-helper 1 type immune response","GO:0002826","0.00039366277429996613",7,235,3,18117,"HAVCR2,IL1RL1,IL33"]
["GO:BP","positive regulation of natural killer cell differentiation","GO:0032825","0.00039366277429996613",7,235,3,18117,"AXL,STAT5B,RASGRP1"]
["GO:BP","regulation of interleukin-13 production","GO:0032656","0.00039529164200057145",18,235,4,18117,"PRKCZ,IL1RAP,IL33,LGALS9"]
["GO:BP","pyroptosis","GO:0070269","0.00039529164200057145",18,235,4,18117,"AIM2,CASP4,ZBP1,DHX9"]
["GO:BP","positive regulation of myeloid leukocyte mediated immunity","GO:0002888","0.00039529164200057145",18,235,4,18117,"C3,STAP1,PTAFR,ITGAM"]
["GO:BP","macrophage activation involved in immune response","GO:0002281","0.00039529164200057145",18,235,4,18117,"GRN,HAVCR2,HMGB1,IL33"]
["GO:BP","regulation of tolerance induction","GO:0002643","0.00039529164200057145",18,235,4,18117,"HAVCR2,HMGB1,IDO1,IL2RA"]
["GO:BP","negative regulation of proteolysis","GO:0045861","0.00039886030138035634",359,235,15,18117,"APP,SERPINB9,SERPINE1,SERPINF1,NR1H3,HGF,C3,SNCA,PTGS2,IL1R2,LRRK2,LXN,THBS1,TIMP1,DDX3X"]
["GO:BP","regulation of lymphocyte apoptotic process","GO:0070228","0.00041060188504299784",55,235,6,18117,"BCL6,PRKCQ,IDO1,LGALS9,LYN,CCL5"]
["GO:BP","cell morphogenesis","GO:0000902","0.00043257443205708853",1037,235,29,18117,"EGFR,EPHA2,APOE,APP,RPS6KA5,NOTCH1,NOTCH2,ATRN,AXL,BCL6,FN1,GJA1,HCK,HGF,SLIT2,PRKCA,PRKCQ,PRKCZ,ICAM1,ITGB6,KIT,LIPA,LRRK2,MAPK14,TGFB1,CDH5,UNC13D,CSF1R,DICER1"]
["GO:BP","cellular response to mechanical stimulus","GO:0071260","0.00043257443205708853",80,235,7,18117,"EGFR,PDE2A,GJA1,PTGS2,NFKB1,TGFB1,TLR4"]
["GO:BP","negative regulation of catabolic process","GO:0009895","0.0004394733282466281",321,235,14,18117,"EGFR,NUPR1,PIK3CG,HGF,SLC11A1,SNCA,PPARA,STAT3,HMOX1,LRRK2,MAPK14,MAPKAPK2,TIMP1,DHX9"]
["GO:BP","response to carbohydrate","GO:0009743","0.00044363384580735213",243,235,12,18117,"AGER,SERPINF1,GJA1,GSTP1,CALCRL,PPARD,PTGS2,ICAM1,LPL,LYN,TGFB1,THBS1"]
["GO:BP","positive regulation of vasoconstriction","GO:0045907","0.00044559818734098806",35,235,5,18117,"EGFR,GJA1,PTAFR,PTGS2,ICAM1"]
["GO:BP","regulation of natural killer cell activation","GO:0032814","0.00044559818734098806",35,235,5,18117,"AXL,HAVCR2,STAT5B,IL18,RASGRP1"]
["GO:BP","regulation of alpha-beta T cell proliferation","GO:0046640","0.00044559818734098806",35,235,5,18117,"IL18,LGALS9,CCR2,CD28,CD81"]
["GO:BP","positive regulation of cellular carbohydrate metabolic process","GO:0010676","0.00045179963286203607",56,235,6,18117,"SNCA,PPARA,PTAFR,PTPN2,HMGB1,IGF1"]
["GO:BP","regulation of organelle organization","GO:0033043","0.00046123693564148217",1203,235,32,18117,"MCPH1,SDC1,RPS6KA5,NOTCH2,NUPR1,P2RX7,ATM,PDE2A,BCL6,GRN,HCK,HGF,SLIT2,SNCA,STAP1,PRKCQ,PRKD1,ICAM1,IGF1,IL1RAP,JAM3,LRRK2,RICTOR,TGFB1,CD28,CD47,CDH5,TRPV4,VPS35,CSF1R,CX3CL1,CYLD"]
["GO:BP","striated muscle cell proliferation","GO:0014855","0.0004647167106552094",81,235,7,18117,"NOTCH1,GJA1,PPARD,STAT3,JAK2,MAPK14,RBPJ"]
["GO:BP","multicellular organism growth","GO:0035264","0.0004779841753568542",140,235,9,18117,"APP,NOTCH2,ATM,ATRN,STAT3,STAT5A,STAT5B,IGF1,CSF1"]
["GO:BP","mammary gland development","GO:0030879","0.0004779841753568542",140,235,9,18117,"ELF3,EPHA2,STAT5A,STAT5B,JAK2,TGFB1,CEBPB,CSF1,CSF1R"]
["GO:BP","positive regulation of macrophage derived foam cell differentiation","GO:0010744","0.0004859041084184629",19,235,4,18117,"NFKB1,IL18,LPL,CSF1"]
["GO:BP","interleukin-5 production","GO:0032634","0.0004859041084184629",19,235,4,18117,"PRKCZ,IL1RAP,IL1RL1,IL33"]
["GO:BP","positive regulation of multi-organism process","GO:0043902","0.0004859041084184629",19,235,4,18117,"EDNRB,PRKCA,LY86,LY96"]
["GO:BP","positive regulation of histone deacetylation","GO:0031065","0.0004859041084184629",19,235,4,18117,"BCL6,PRKD1,LRRK2,TGFB1"]
["GO:BP","obsolete positive regulation of blood vessel diameter","GO:0097755","0.0004859041084184629",19,235,4,18117,"EGFR,GJA1,PPARD,PTAFR"]
["GO:BP","regulation of interleukin-5 production","GO:0032674","0.0004859041084184629",19,235,4,18117,"PRKCZ,IL1RAP,IL1RL1,IL33"]
["GO:BP","positive regulation of CREB transcription factor activity","GO:0032793","0.0004859041084184629",19,235,4,18117,"RPS6KA5,CAMK1D,PRKD1,CD200"]
["GO:BP","regulation of glial cell migration","GO:1903975","0.0004859041084184629",19,235,4,18117,"STAP1,CCR2,CSF1,CX3CL1"]
["GO:BP","regulation of neurogenesis","GO:0050767","0.0004859041084184629",366,235,15,18117,"APPL2,SERPINF1,NOTCH1,FN1,SLIT2,PPARG,HMGB2,KIT,LDLR,LYN,TGFB1,TLR2,TNFRSF1B,DICER1,CX3CL1"]
["GO:BP","nucleotide metabolic process","GO:0009117","0.0004912890125829945",544,235,19,18117,"ENPP3,EPHA2,ABCD1,AK7,APP,RORA,NUPR1,P2RX7,PDE2A,PDE5A,SNCA,PPARA,STAT3,PTGIS,PTGS2,IDO1,IGF1,LRRK2,HK1"]
["GO:BP","regulation of peptide secretion","GO:0002791","0.0004926181601011659",325,235,14,18117,"EGFR,ALOX5,APOE,NR1H3,GJA1,PPARD,PRKCA,IGF1,JAK2,TCIRG1,TLR2,TLR4,CCL5,CD200"]
["GO:BP","smooth muscle contraction","GO:0006939","0.0004934824010962135",110,235,8,18117,"EDNRA,EDNRB,SCNN1B,P2RX1,CALCRL,PTAFR,PTGS2,KIT"]
["GO:BP","regulation of Notch signaling pathway","GO:0008593","0.0004934824010962135",110,235,8,18117,"EGFR,ELF3,NOTCH1,BCL6,STAT3,NFKBIA,KIT,RBPJ"]
["GO:BP","positive regulation of secretion by cell","GO:1903532","0.0004943305538015503",285,235,13,18117,"EGFR,SDC1,GJA1,PLA2G4A,SNCA,PPARD,PTAFR,IGF1,ITGAM,JAK2,TLR2,TLR4,UNC13D"]
["GO:BP","positive regulation of binding","GO:0051099","0.0004943305538015503",174,235,10,18117,"ACE,APOE,APP,PPARG,HMGB1,HMGB2,IGF1,JAK2,LRRK2,DHX9"]
["GO:BP","response to estradiol","GO:0032355","0.0004980531882103884",141,235,9,18117,"EGFR,GJA1,GPX4,GSTP1,STAT3,STAT5B,PTGFR,PTGS2,TGFB1"]
["GO:BP","aortic valve development","GO:0003176","0.000502498680028633",36,235,5,18117,"NOTCH1,SLIT2,RBPJ,TGFB1,TNFRSF1B"]
["GO:BP","synaptic signaling","GO:0099536","0.000504870839770898",738,235,23,18117,"EGFR,ABR,AGER,APOE,APP,P2RX1,P2RX7,BCR,PMP22,SNAP23,SNCA,STAT3,PRKCZ,PTGS2,PXK,IL1RAP,JAK2,KIT,LRRK2,CCR2,CNR2,CX3CL1,DAGLB"]
["GO:BP","negative regulation of nucleobase-containing compound metabolic process","GO:0045934","0.000511390337135295",1548,235,38,18117,"MCPH1,MECOM,EDNRB,ELF3,RPS6KA5,NOTCH1,NOTCH2,NR1H3,NUPR1,ATM,PDCD4,PDE2A,BCL6,FABP4,GJA1,HDAC9,SLC11A1,SNCA,PPARA,PPARD,PPARG,STAT3,PTPN2,NFKB1,HMGB1,HMGB2,IL33,MAPK14,MAPKAPK2,RBPJ,RELB,TGFB1,TRPV4,CEBPB,CIITA,CTNNBIP1,DHX9,DICER1"]
["GO:BP","second-messenger-mediated signaling","GO:0019932","0.0005216186242149533",327,235,14,18117,"EDNRB,EGFR,APOE,P2RX7,PDE2A,FPR1,PTGFR,NDUFS4,IGF1,LRRK2,THBS1,CCL4,CCR2,CMKLR1"]
["GO:BP","transmembrane receptor protein serine/threonine kinase signaling pathway","GO:0007178","0.0005260727443705397",369,235,15,18117,"ADAM17,APPL2,NOTCH1,NOTCH2,PDCD4,PPARA,PPARG,PRKCZ,ITGB6,JAK2,MAPK14,RBPJ,TGFB1,THBS1,CDH5"]
["GO:BP","regulation of vascular endothelial growth factor production","GO:0010574","0.0005386544737409262",58,235,6,18117,"RORA,C5AR1,C3,PTGS2,CCR2,CXCL17"]
["GO:BP","response to ischemia","GO:0002931","0.0005386544737409262",58,235,6,18117,"P2RX7,GJA1,HSPD1,CSF1,CSF1R,CX3CL1"]
["GO:BP","macromolecule localization","GO:0033036","0.0005525489735986198",3218,235,65,18117,"MCPH1,EGFR,EPHA2,ABCC1,ABCD1,ACE,AGER,ALOX5,MFHAS1,APOE,APPL2,RPS19,NR1H3,P2RX7,ATM,BCL6,FABP4,GBP5,GJA1,C3,CALCRL,PLA2G4A,SNAP23,SNCA,PPARA,PPARD,PPARG,STAT3,STAT5B,PRKCA,PRKCZ,PRKD1,PTGS2,PTPN2,NFKB1,NFKBIA,HSPD1,HYAL2,IGF1,ITGAM,JAK2,JAM3,KPNA6,LDLR,LPCAT3,LPL,LRRK2,MAPK14,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCL5,CD200,CD68,CD81,CDH5,TNFAIP3,VPS35,CSRP3,DHX9,DDX3X,DUOXA1,HK1"]
["GO:BP","positive regulation of protein transport","GO:0051222","0.0005539150910741289",329,235,14,18117,"EGFR,GJA1,PPARD,PRKCZ,PRKD1,PTGS2,HYAL2,IGF1,ITGAM,JAK2,MAPK14,TLR2,TLR4,CD81"]
["GO:BP","response to metal ion","GO:0010038","0.0005561429749991875",371,235,15,18117,"EGFR,ALOX5AP,APP,SDC1,SERPINF1,FABP4,SNCA,PTGS2,HMOX1,ICAM1,KIT,LRRK2,TCIRG1,THBS1,CYBB"]
["GO:BP","carboxylic acid biosynthetic process","GO:0046394","0.0005709337909111695",330,235,14,18117,"ABCD1,ALOX5,ALOX5AP,MGLL,NR1H3,GPX4,GSTP1,PLA2G4A,PTGIS,PTGS1,PTGS2,IDO1,LPL,DAGLB"]
["GO:BP","natural killer cell activation","GO:0030101","0.0005710140797377021",84,235,7,18117,"AXL,HAVCR2,STAT5B,IL18,IL18R1,RASGRP1,UNC13D"]
["GO:BP","positive regulation of lipid localization","GO:1905954","0.0005874137334350856",113,235,8,18117,"APOE,NR1H3,C3,PLA2G4A,NFKB1,NFKBIA,LPCAT3,LPL"]
["GO:BP","organic acid transport","GO:0015849","0.0005874137334350856",331,235,14,18117,"ABCC1,ABCD1,ACE,APOE,FABP4,GJA1,SLC11A1,SLC7A2,PLA2G4A,SNCA,PPARA,PPARD,PPARG,THBS1"]
["GO:BP","lipid oxidation","GO:0034440","0.0005874137334350856",113,235,8,18117,"ABCD1,ALOX5,APPL2,PLA2G7,PPARA,PPARD,PPARG,MAPK14"]
["GO:BP","I-kappaB phosphorylation","GO:0007252","0.0005881823193012759",20,235,4,18117,"SIRPA,TLR2,TLR4,CX3CL1"]
["GO:BP","neuroblast proliferation","GO:0007405","0.0005881823193012759",59,235,6,18117,"AKNA,NOTCH1,LRRK2,TGFB1,CX3CL1,DAGLB"]
["GO:BP","response to muramyl dipeptide","GO:0032495","0.0005881823193012759",20,235,4,18117,"NOTCH1,NFKBIA,MAPK14,TNFAIP3"]
["GO:BP","T-helper 1 cell differentiation","GO:0045063","0.0005881823193012759",20,235,4,18117,"SPN,HMGB1,IL18R1,RELB"]
["GO:BP","regulation of chronic inflammatory response","GO:0002676","0.0005912908388277837",8,235,3,18117,"IDO1,CCL5,TNFAIP3"]
["GO:BP","regulation of microglial cell migration","GO:1904139","0.0005912908388277837",8,235,3,18117,"STAP1,CSF1,CX3CL1"]
["GO:BP","negative regulation of interferon-gamma-mediated signaling pathway","GO:0060336","0.0005912908388277837",8,235,3,18117,"NR1H3,PPARG,PTPN2"]
["GO:BP","microglial cell migration","GO:1904124","0.0005912908388277837",8,235,3,18117,"STAP1,CSF1,CX3CL1"]
["GO:BP","osteoclast proliferation","GO:0002158","0.0005912908388277837",8,235,3,18117,"TCIRG1,TNFAIP3,CSF1"]
["GO:BP","positive regulation of aspartic-type peptidase activity","GO:1905247","0.0005912908388277837",8,235,3,18117,"AGER,GRN,LYN"]
["GO:BP","positive regulation of lipopolysaccharide-mediated signaling pathway","GO:0031666","0.0005912908388277837",8,235,3,18117,"PRKCA,LY86,LY96"]
["GO:BP","negative regulation of response to interferon-gamma","GO:0060331","0.0005912908388277837",8,235,3,18117,"NR1H3,PPARG,PTPN2"]
["GO:BP","hematopoietic stem cell migration","GO:0035701","0.0005912908388277837",8,235,3,18117,"JAM3,KIT,CCR2"]
["GO:BP","developmental growth","GO:0048589","0.0005981809924541257",649,235,21,18117,"APOE,APP,NOTCH1,NOTCH2,ATM,ATRN,FN1,GJA1,SLIT2,PPARA,PPARD,STAT3,STAT5A,STAT5B,PRKCZ,IGF1,MAPK14,RBPJ,TGFB1,CD81,CSF1"]
["GO:BP","regulation of smooth muscle cell migration","GO:0014910","0.0006063237266428118",85,235,7,18117,"ACE,SERPINE1,GSTP1,SLIT2,PPARD,IGF1,CCL5"]
["GO:BP","heterocycle catabolic process","GO:0046700","0.0006127670585363208",602,235,20,18117,"ENPP3,ABCD1,RPS19,ATM,PDE2A,PDE5A,SLC11A1,PRKCA,PSMA1,HMGB1,HMGB2,HMOX1,IDO1,MAPK14,MAPKAPK2,TNFRSF1B,DHX9,DICER1,DNASE1,DROSHA"]
["GO:BP","nucleoside phosphate metabolic process","GO:0006753","0.0006174915356684438",555,235,19,18117,"ENPP3,EPHA2,ABCD1,AK7,APP,RORA,NUPR1,P2RX7,PDE2A,PDE5A,SNCA,PPARA,STAT3,PTGIS,PTGS2,IDO1,IGF1,LRRK2,HK1"]
["GO:BP","negative regulation of endopeptidase activity","GO:0010951","0.0006191938602865678",253,235,12,18117,"APP,SERPINB9,SERPINE1,SERPINF1,HGF,C3,SNCA,PTGS2,LXN,THBS1,TIMP1,DDX3X"]
["GO:BP","organic cyclic compound catabolic process","GO:1901361","0.0006216816827768348",651,235,21,18117,"ENPP3,ABCD1,APOE,RPS19,ATM,PDE2A,PDE5A,SLC11A1,PRKCA,PSMA1,HMGB1,HMGB2,HMOX1,IDO1,MAPK14,MAPKAPK2,TNFRSF1B,DHX9,DICER1,DNASE1,DROSHA"]
["GO:BP","regulation of Wnt signaling pathway","GO:0030111","0.0006312862956863766",376,235,15,18117,"EGFR,APOE,APP,NOTCH1,GPRC5B,PSMA1,NFKB1,LRRK2,MAPK14,RBPJ,TLR2,TNFAIP3,CTNNBIP1,CYLD,DDX3X"]
["GO:BP","amyloid-beta clearance","GO:0097242","0.000633885346456745",38,235,5,18117,"APOE,C5AR1,C3,ITGAM,LDLR"]
["GO:BP","alpha-beta T cell proliferation","GO:0046633","0.000633885346456745",38,235,5,18117,"IL18,LGALS9,CCR2,CD28,CD81"]
["GO:BP","monocyte differentiation","GO:0030224","0.000633885346456745",38,235,5,18117,"PDE2A,PPARG,CSF1,CSF1R,CTNNBIP1"]
["GO:BP","positive regulation of protein tyrosine kinase activity","GO:0061098","0.000633885346456745",60,235,6,18117,"ACE,ADAM17,GPRC5B,STAP1,CCL5,CSF1R"]
["GO:BP","regulation of lipid catabolic process","GO:0050994","0.000633885346456745",60,235,6,18117,"ABCD1,PIK3CG,PPARA,LDLR,RARRES2,DAGLB"]
["GO:BP","triglyceride catabolic process","GO:0019433","0.000633885346456745",38,235,5,18117,"MGLL,PIK3CG,FABP4,LPL,DAGLB"]
["GO:BP","morphogenesis of a branching epithelium","GO:0061138","0.0006608056052593093",181,235,10,18117,"EDNRA,EPHA2,NOTCH1,HGF,SLIT2,SOCS3,TGFB1,TGM2,CSF1,CTNNBIP1"]
["GO:BP","memory","GO:0007613","0.0006890645698547354",116,235,8,18117,"APOE,SERPINF1,CAMK4,PJA2,PRKCZ,PTGS2,LDLR,CEBPB"]
["GO:BP","cellular nitrogen compound catabolic process","GO:0044270","0.0006922521785961019",608,235,20,18117,"ENPP3,ABCD1,RPS19,ATM,PDE2A,PDE5A,SLC11A1,PRKCA,PSMA1,HMGB1,HMGB2,HMOX1,IDO1,MAPK14,MAPKAPK2,TNFRSF1B,DHX9,DICER1,DNASE1,DROSHA"]
["GO:BP","regulation of interleukin-2 production","GO:0032663","0.0006926604944512111",61,235,6,18117,"HAVCR2,STAT5B,PRKCQ,CCR2,CD28,TNFAIP3"]
["GO:BP","membrane protein proteolysis","GO:0033619","0.0006926604944512111",61,235,6,18117,"ADAM17,APOE,PRKCQ,NFKB1,TIMP1,TNFRSF1B"]
["GO:BP","cellular carbohydrate metabolic process","GO:0044262","0.0006927186496227362",296,235,13,18117,"AOAH,RORA,NUPR1,PLA2G4A,SNCA,PPARA,STAT3,PTAFR,PTPN2,NDST1,HMGB1,IGF1,HK1"]
["GO:BP","metal ion transport","GO:0030001","0.0006964533044255821",514,235,18,18117,"P2RX1,P2RX7,PIK3CG,GJA1,SLC11A1,CALCRL,SNCA,PRKD1,PTGS2,ICAM1,IL16,LYN,TGFB1,CCL4,CCL5,TRPV4,CX3CL1,CYSLTR1"]
["GO:BP","protein localization to organelle","GO:0033365","0.0007069938181969002",1017,235,28,18117,"MCPH1,MFHAS1,APPL2,RPS19,ATM,GBP5,GJA1,STAT3,PRKCZ,PRKD1,PTGS2,NFKBIA,HSPD1,HYAL2,JAK2,KPNA6,LRRK2,MAPK14,TCIRG1,TGFB1,CD68,CD81,TNFAIP3,VPS35,CSRP3,DHX9,DDX3X,HK1"]
["GO:BP","organic acid biosynthetic process","GO:0016053","0.0007104197413263327",338,235,14,18117,"ABCD1,ALOX5,ALOX5AP,MGLL,NR1H3,GPX4,GSTP1,PLA2G4A,PTGIS,PTGS1,PTGS2,IDO1,LPL,DAGLB"]
["GO:BP","negative regulation of JNK cascade","GO:0046329","0.0007133344405581425",39,235,5,18117,"MECOM,PDCD4,GSTP1,SIRPA,CYLD"]
["GO:BP","regulation of cellular carbohydrate metabolic process","GO:0010675","0.0007265776160199231",149,235,9,18117,"RORA,NUPR1,SNCA,PPARA,STAT3,PTAFR,PTPN2,HMGB1,IGF1"]
["GO:BP","negative regulation of hydrolase activity","GO:0051346","0.0007265776160199231",470,235,17,18117,"APP,SERPINB9,SERPINE1,SERPINF1,HDAC9,HGF,C3,SLIT2,SNCA,PRKCZ,PTGS2,PXK,LRRK2,LXN,THBS1,TIMP1,DDX3X"]
["GO:BP","regulation of vascular associated smooth muscle cell proliferation","GO:1904705","0.0007393558442835848",88,235,7,18117,"PDCD4,GJA1,GSTP1,PPARG,HMOX1,IGF1,JAK2"]
["GO:BP","vascular associated smooth muscle cell proliferation","GO:1990874","0.0007393558442835848",88,235,7,18117,"PDCD4,GJA1,GSTP1,PPARG,HMOX1,IGF1,JAK2"]
["GO:BP","muscle system process","GO:0003012","0.0007430674269347232",471,235,17,18117,"EDNRA,EDNRB,SCNN1B,NOTCH1,P2RX1,PIK3CG,GJA1,CALCRL,PPARA,PRKCA,PTAFR,PTGS2,HMOX1,IGF1,KIT,TNFRSF1B,CSRP3"]
["GO:BP","vascular endothelial growth factor production","GO:0010573","0.0007512980657479482",62,235,6,18117,"RORA,C5AR1,C3,PTGS2,CCR2,CXCL17"]
["GO:BP","regulation of protein import into nucleus","GO:0042306","0.0007512980657479482",62,235,6,18117,"PRKD1,PTGS2,HYAL2,JAK2,MAPK14,TGFB1"]
["GO:BP","regulation of anatomical structure size","GO:0090066","0.0007598316927325526",518,235,18,18117,"EDNRA,EDNRB,EGFR,ACE,APOE,SCNN1B,P2RX1,P2RX7,FN1,GJA1,HCK,SLIT2,PTAFR,PTGS2,ICAM1,LRRK2,RICTOR,TRPV4"]
["GO:BP","response to hydrogen peroxide","GO:0042542","0.0007600567161288057",150,235,9,18117,"SDC1,AXL,HGF,SIRPA,HMOX1,HSPD1,IL18RAP,LRRK2,TNFAIP3"]
["GO:BP","cellular response to heat","GO:0034605","0.0007647954713479354",118,235,8,18117,"ATM,PTGS2,HMOX1,HSPD1,LYN,MAPKAPK2,THBS1,TRPV4"]
["GO:BP","regulation of cell-substrate adhesion","GO:0010810","0.0007918101867706748",222,235,11,18117,"ABI3BP,SERPINE1,NOTCH1,BCL6,FN1,PRKCZ,JAK2,THBS1,UNC13D,CSF1,CX3CL1"]
["GO:BP","cellular response to osmotic stress","GO:0071470","0.0007950659512852515",40,235,5,18117,"STK39,PTGS2,RELB,TRPV4,DDX3X"]
["GO:BP","regulation of actin cytoskeleton reorganization","GO:2000249","0.0007950659512852515",40,235,5,18117,"NOTCH2,HCK,STAP1,TGFB1,CSF1R"]
["GO:BP","triglyceride homeostasis","GO:0070328","0.0007950659512852515",40,235,5,18117,"APOE,RORA,NR1H3,IL18,LPL"]
["GO:BP","response to dexamethasone","GO:0071548","0.0007950659512852515",40,235,5,18117,"EGFR,SERPINF1,PTAFR,ICAM1,TGFB1"]
["GO:BP","T cell homeostasis","GO:0043029","0.0007950659512852515",40,235,5,18117,"STAT5B,IL2RA,LGALS9,TCIRG1,TGFB1"]
["GO:BP","nucleotide-binding oligomerization domain containing signaling pathway","GO:0070423","0.0007950659512852515",40,235,5,18117,"NFKBIA,IRAK2,TLR4,TNFAIP3,CYLD"]
["GO:BP","acylglycerol homeostasis","GO:0055090","0.0007950659512852515",40,235,5,18117,"APOE,RORA,NR1H3,IL18,LPL"]
["GO:BP","regulation of ATP metabolic process","GO:1903578","0.0008050502669048546",119,235,8,18117,"ABCD1,APP,NUPR1,P2RX7,SNCA,PPARA,STAT3,IGF1"]
["GO:BP","ion transport","GO:0006811","0.0008064377053148948",3661,235,71,18117,"EDNRA,EGFR,ABCC1,ABCD1,ACE,ALOX5,APOE,APP,APPL2,SCN9A,SCNN1B,RPS19,NR1H3,P2RX1,P2RX7,PIK3CG,FABP4,GJA1,C3,SLC11A1,SLC7A2,CALCRL,PLA2G4A,SNAP23,SNCA,PPARA,PPARD,PPARG,STAT3,STK39,PRKCA,PRKCZ,PRKD1,PTAFR,PTGS2,PXK,NFKB1,NFKBIA,HSPD1,HYAL2,ICAM1,IGF1,IL16,ITGAM,JAK2,KPNA6,LDLR,LPCAT3,LRRK2,LYN,MAPK14,TCIRG1,TGFB1,THBS1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD47,CD81,TRPV4,VPS35,CEBPB,CTSS,DHX9,CX3CL1,CYBB,CYSLTR1,DUOXA1"]
["GO:BP","regulation of endothelial cell apoptotic process","GO:2000351","0.0008097078204718362",63,235,6,18117,"SERPINE1,PDCD4,ICAM1,THBS1,CDH5,TNFAIP3"]
["GO:BP","regulation of B cell proliferation","GO:0030888","0.0008097078204718362",63,235,6,18117,"ATM,BCL6,LYN,TLR4,CD300A,CD81"]
["GO:BP","interleukin-2 production","GO:0032623","0.0008097078204718362",63,235,6,18117,"HAVCR2,STAT5B,PRKCQ,CCR2,CD28,TNFAIP3"]
["GO:BP","cellular response to corticosteroid stimulus","GO:0071384","0.0008097078204718362",63,235,6,18117,"EGFR,SCNN1B,SERPINF1,GSTP1,ICAM1,TGFB1"]
["GO:BP","regulation of tumor necrosis factor-mediated signaling pathway","GO:0010803","0.0008097078204718362",63,235,6,18117,"ADAM17,GSTP1,CASP4,PTPN2,TNFAIP3,CYLD"]
["GO:BP","negative regulation of macrophage colony-stimulating factor signaling pathway","GO:1902227","0.0008211474004336664",2,235,2,18117,"STAP1,PTPN2"]
["GO:BP","positive regulation of response to macrophage colony-stimulating factor","GO:1903971","0.0008211474004336664",2,235,2,18117,"TLR2,TLR4"]
["GO:BP","detection of triacyl bacterial lipopeptide","GO:0042495","0.0008211474004336664",2,235,2,18117,"TLR1,TLR2"]
["GO:BP","negative regulation of vacuolar transport","GO:1903336","0.0008211474004336664",2,235,2,18117,"LRRK2,VPS35"]
["GO:BP","positive regulation of growth factor dependent skeletal muscle satellite cell proliferation","GO:1902728","0.0008211474004336664",2,235,2,18117,"STAT3,JAK2"]
["GO:BP","negative regulation of late endosome to lysosome transport","GO:1902823","0.0008211474004336664",2,235,2,18117,"LRRK2,VPS35"]
["GO:BP","negative regulation of mast cell cytokine production","GO:0032764","0.0008211474004336664",2,235,2,18117,"BCL6,HMOX1"]
["GO:BP","negative regulation of eosinophil activation","GO:1902567","0.0008211474004336664",2,235,2,18117,"CCR2,CD300A"]
["GO:BP","positive regulation of skeletal muscle satellite cell proliferation","GO:1902724","0.0008211474004336664",2,235,2,18117,"STAT3,JAK2"]
["GO:BP","negative regulation of cellular catabolic process","GO:0031330","0.0008211474004336664",262,235,12,18117,"NUPR1,PIK3CG,HGF,SLC11A1,SNCA,STAT3,HMOX1,LRRK2,MAPK14,MAPKAPK2,TIMP1,DHX9"]
["GO:BP","negative regulation of CD40 signaling pathway","GO:2000349","0.0008211474004336664",2,235,2,18117,"SLAMF1,TNFAIP3"]
["GO:BP","positive regulation of cellular response to macrophage colony-stimulating factor stimulus","GO:1903974","0.0008211474004336664",2,235,2,18117,"TLR2,TLR4"]
["GO:BP","pinocytosis","GO:0006907","0.0008221300997304878",22,235,4,18117,"APPL2,NR1H3,AXL,MAPKAPK2"]
["GO:BP","regulation of protein localization","GO:0032880","0.0008246496751315736",922,235,26,18117,"EGFR,EPHA2,ALOX5,MFHAS1,APOE,NR1H3,GJA1,PPARD,PRKCA,PRKCZ,PRKD1,PTGS2,HYAL2,IGF1,ITGAM,JAK2,LRRK2,MAPK14,TCIRG1,TGFB1,TLR2,TLR4,CCL5,CD200,CD81,CSRP3"]
["GO:BP","regulation of carbohydrate catabolic process","GO:0043470","0.000827194326970037",90,235,7,18117,"APP,NUPR1,P2RX7,PPARA,STAT3,HMGB1,IGF1"]
["GO:BP","positive regulation of NLRP3 inflammasome complex assembly","GO:1900227","0.0008309775228007675",9,235,3,18117,"GBP5,TLR4,DDX3X"]
["GO:BP","interleukin-23 production","GO:0032627","0.0008309775228007675",9,235,3,18117,"IL17RA,TGFB1,TLR4"]
["GO:BP","interleukin-9-mediated signaling pathway","GO:0038113","0.0008309775228007675",9,235,3,18117,"STAT3,STAT5A,STAT5B"]
["GO:BP","cannabinoid signaling pathway","GO:0038171","0.0008309775228007675",9,235,3,18117,"MGLL,CNR2,DAGLB"]
["GO:BP","cellular response to interleukin-9","GO:0071355","0.0008309775228007675",9,235,3,18117,"STAT3,STAT5A,STAT5B"]
["GO:BP","regulation of interleukin-23 production","GO:0032667","0.0008309775228007675",9,235,3,18117,"IL17RA,TGFB1,TLR4"]
["GO:BP","positive regulation of establishment of protein localization","GO:1904951","0.0008458486728870894",345,235,14,18117,"EGFR,GJA1,PPARD,PRKCZ,PRKD1,PTGS2,HYAL2,IGF1,ITGAM,JAK2,MAPK14,TLR2,TLR4,CD81"]
["GO:BP","somatic diversification of immune receptors via germline recombination within a single locus","GO:0002562","0.0008673219764805181",64,235,6,18117,"ATM,BCL6,HMGB1,HMGB2,HSPD1,CD28"]
["GO:BP","somatic cell DNA recombination","GO:0016444","0.0008673219764805181",64,235,6,18117,"ATM,BCL6,HMGB1,HMGB2,HSPD1,CD28"]
["GO:BP","nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway","GO:0035872","0.0008729364805119603",41,235,5,18117,"NFKBIA,IRAK2,TLR4,TNFAIP3,CYLD"]
["GO:BP","response to growth hormone","GO:0060416","0.0008729364805119603",41,235,5,18117,"STAT3,STAT5A,STAT5B,JAK2,LYN"]
["GO:BP","muscle cell differentiation","GO:0042692","0.0008906790070078851",390,235,15,18117,"EDNRB,SDC1,RORA,NOTCH1,PDCD4,HDAC9,PLD3,PPARA,IGF1,KIT,MAPK14,RBPJ,TGFB1,CD81,CSRP3"]
["GO:BP","positive regulation of cellular protein catabolic process","GO:1903364","0.0008953384633714789",154,235,9,18117,"APOE,NUPR1,IL33,LDLR,LRRK2,CD81,TNFAIP3,VPS35,CTSC"]
["GO:BP","aromatic compound catabolic process","GO:0019439","0.0009107020660002335",623,235,20,18117,"ENPP3,ABCD1,RPS19,ATM,PDE2A,PDE5A,SLC11A1,PRKCA,PSMA1,HMGB1,HMGB2,HMOX1,IDO1,MAPK14,MAPKAPK2,TNFRSF1B,DHX9,DICER1,DNASE1,DROSHA"]
["GO:BP","glycerolipid metabolic process","GO:0046486","0.0009278776043618058",436,235,16,18117,"ABHD12,MGLL,APOE,NR1H3,ATM,PIK3CG,FABP4,C3,PLA2G4A,PLA2G7,SOCS3,LDLR,LPCAT3,LPL,CSF1R,DAGLB"]
["GO:BP","regulation of tissue remodeling","GO:0034103","0.0009371319591971558",92,235,7,18117,"EGFR,AGER,P2RX7,PRKCA,IL18,TNFAIP3,CSF1R"]
["GO:BP","regulation of protein import","GO:1904589","0.0009386855238084951",65,235,6,18117,"PRKD1,PTGS2,HYAL2,JAK2,MAPK14,TGFB1"]
["GO:BP","negative regulation of chemotaxis","GO:0050922","0.0009386855238084951",65,235,6,18117,"NOTCH1,GSTP1,SLIT2,STAP1,PTPN2,THBS1"]
["GO:BP","negative regulation of peptidase activity","GO:0010466","0.0009615303342605277",267,235,12,18117,"APP,SERPINB9,SERPINE1,SERPINF1,HGF,C3,SNCA,PTGS2,LXN,THBS1,TIMP1,DDX3X"]
["GO:BP","eosinophil migration","GO:0072677","0.0009653494822453312",23,235,4,18117,"CCL4,CCL5,CD300A,CX3CL1"]
["GO:BP","response to muscle stretch","GO:0035994","0.0009653494822453312",23,235,4,18117,"NFKB1,NFKBIA,MAPK14,CSRP3"]
["GO:BP","regulation of macrophage differentiation","GO:0045649","0.0009653494822453312",23,235,4,18117,"PRKCA,PTPN2,TGFB1,CSF1"]
["GO:BP","positive regulation of natural killer cell activation","GO:0032816","0.0009653494822453312",23,235,4,18117,"AXL,STAT5B,IL18,RASGRP1"]
["GO:BP","regulation of brown fat cell differentiation","GO:0090335","0.0009653494822453312",23,235,4,18117,"METRNL,PTGS2,MAPK14,TRPV4"]
["GO:BP","positive regulation of protein import into nucleus","GO:0042307","0.0009676852566078022",42,235,5,18117,"PRKD1,PTGS2,HYAL2,JAK2,MAPK14"]
["GO:BP","response to interleukin-7","GO:0098760","0.0009676852566078022",42,235,5,18117,"STAT3,STAT5A,STAT5B,HMGB1,HSPD1"]
["GO:BP","cellular response to interleukin-7","GO:0098761","0.0009676852566078022",42,235,5,18117,"STAT3,STAT5A,STAT5B,HMGB1,HSPD1"]
["GO:BP","cell junction assembly","GO:0034329","0.0009676852566078022",438,235,16,18117,"EPHA2,ACE,APP,BCR,FN1,GJA1,SNCA,PRKCA,IL1RAP,JAM3,LRFN5,THBS1,TLR2,CDH5,TRPV4,VPS35"]
["GO:BP","smooth muscle cell migration","GO:0014909","0.000992359920545904",93,235,7,18117,"ACE,SERPINE1,GSTP1,SLIT2,PPARD,IGF1,CCL5"]
["KEGG","AGE-RAGE signaling pathway in diabetic complications","KEGG:04933","0.0000020290185945994553",100,191,15,8001,"AGER,SERPINE1,F3,FN1,STAT3,STAT5A,STAT5B,PRKCA,PRKCZ,NFKB1,ICAM1,JAK2,MAPK14,TGFB1,CYBB"]
["KEGG","NF-kappa B signaling pathway","KEGG:04064","0.0000020290185945994553",102,191,15,8001,"ATM,PRKCQ,PTGS2,NFKB1,NFKBIA,ICAM1,IL1R1,LY96,LYN,RELB,TLR4,CCL4,TNFAIP3,CXCL2,CYLD"]
["KEGG","TNF signaling pathway","KEGG:04668","0.000004937782816834136",112,191,15,8001,"RPS6KA5,SOCS3,PTGS2,NFKB1,NFKBIA,ICAM1,IL18R1,MAPK14,CCL5,TNFAIP3,TNFRSF1B,CEBPB,CSF1,CX3CL1,CXCL2"]
["KEGG","Th17 cell differentiation","KEGG:04659","0.00004416368913619861",104,191,13,8001,"RORA,STAT3,STAT5A,STAT5B,PRKCQ,NFKB1,NFKBIA,IL1R1,IL1RAP,IL2RA,JAK2,MAPK14,TGFB1"]
["KEGG","Tuberculosis","KEGG:05152","0.00004416368913619861",175,191,17,8001,"FCER1G,C3,NFKB1,HSPD1,IL18,IRAK2,ITGAM,JAK2,MAPK14,TCIRG1,TGFB1,TLR1,TLR2,TLR4,CEBPB,CIITA,CTSS"]
["KEGG","Leishmaniasis","KEGG:05140","0.00004416368913619861",72,191,11,8001,"C3,PTGS2,NFKB1,NFKBIA,ITGAM,JAK2,MAPK14,TGFB1,TLR2,TLR4,CYBB"]
["KEGG","Malaria","KEGG:05144","0.00006266115169826733",49,191,9,8001,"SDC1,HGF,ICAM1,IL18,TGFB1,THBS1,TLR2,TLR4,CD81"]
["KEGG","Toxoplasmosis","KEGG:05145","0.00006266115169826733",109,191,13,8001,"ALOX5,PIK3CG,STAT3,NFKB1,NFKBIA,JAK2,LDLR,LY96,MAPK14,TGFB1,TLR2,TLR4,CIITA"]
["KEGG","Viral protein interaction with cytokine and cytokine receptor","KEGG:04061","0.00009709975666819753",98,191,12,8001,"IL18,IL18R1,IL18RAP,IL2RA,CCL4,CCL5,CCR2,TNFRSF1B,CSF1,CSF1R,CX3CL1,CXCL2"]
["KEGG","PD-L1 expression and PD-1 checkpoint pathway in cancer","KEGG:05235","0.00014259806194037098",89,191,11,8001,"EGFR,STAT3,PRKCQ,NFKB1,NFKBIA,JAK2,MAPK14,RASGRP1,TLR2,TLR4,CD28"]
["KEGG","Legionellosis","KEGG:05134","0.00014259806194037098",57,191,9,8001,"C3,NFKB1,NFKBIA,HSPD1,IL18,ITGAM,TLR2,TLR4,CXCL2"]
["KEGG","Epithelial cell signaling in Helicobacter pylori infection","KEGG:05120","0.00014259806194037098",70,191,10,8001,"EGFR,ADAM17,NFKB1,NFKBIA,JAM3,LYN,MAPK14,TCIRG1,CCL5,CXCL2"]
["KEGG","Th1 and Th2 cell differentiation","KEGG:04658","0.00014259806194037098",89,191,11,8001,"NOTCH1,NOTCH2,STAT5A,STAT5B,PRKCQ,NFKB1,NFKBIA,IL2RA,JAK2,MAPK14,RBPJ"]
["KEGG","Osteoclast differentiation","KEGG:04380","0.00014259806194037098",125,191,13,8001,"SIRPA,CAMK4,PPARG,SOCS3,NFKB1,NFKBIA,IL1R1,MAPK14,RELB,TGFB1,CSF1,CSF1R,CYLD"]
["KEGG","Cytokine-cytokine receptor interaction","KEGG:04060","0.00014259806194037098",293,191,21,8001,"IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RAP,IL1RL1,IL2RA,IL33,TGFB1,CCL4,CCL5,CCR2,TNFRSF1B,CSF1,CSF1R,CX3CL1,CXCL17,CXCL2"]
["KEGG","Inflammatory bowel disease","KEGG:05321","0.0002366987262286116",62,191,9,8001,"RORA,STAT3,NFKB1,IL18,IL18R1,IL18RAP,TGFB1,TLR2,TLR4"]
["KEGG","Pathways in cancer","KEGG:05200","0.00030739889514974953",529,191,29,8001,"MECOM,EDNRA,EDNRB,EGFR,RPS6KA5,NOTCH1,NOTCH2,BCR,FGFR1,FN1,GSTP1,HGF,PPARD,PPARG,STAT3,STAT5A,STAT5B,PRKCA,PTGS2,NFKB1,NFKBIA,HMOX1,IGF1,IL2RA,JAK2,KIT,RASGRP1,TGFB1,CSF1R"]
["KEGG","MAPK signaling pathway","KEGG:04010","0.0003245190691957901",294,191,20,8001,"MECOM,EGFR,EPHA2,RPS6KA5,FGFR1,HGF,PLA2G4A,PRKCA,NFKB1,IGF1,IL1R1,IL1RAP,KIT,MAPK14,MAPKAPK2,RASGRP1,RELB,TGFB1,CSF1,CSF1R"]
["KEGG","Amoebiasis","KEGG:05146","0.00036936684378261923",101,191,11,8001,"SERPINB9,FN1,PRKCA,NFKB1,IL1R1,IL1R2,ITGAM,TGFB1,TLR2,TLR4,CXCL2"]
["KEGG","Rheumatoid arthritis","KEGG:05323","0.0005438803214102909",88,191,10,8001,"ICAM1,IL18,TCIRG1,TGFB1,TLR2,TLR4,CCL5,CD28,CSF1,CXCL2"]
["KEGG","Neutrophil extracellular trap formation","KEGG:04613","0.0005438803214102909",189,191,15,8001,"AGER,C5AR1,FPR1,FPR3,HDAC9,C3,CASP4,PRKCA,NFKB1,HMGB1,ITGAM,MAPK14,TLR2,TLR4,CYBB"]
["KEGG","HIF-1 signaling pathway","KEGG:04066","0.0006522987465423044",109,191,11,8001,"EGFR,SERPINE1,STAT3,PRKCA,NFKB1,HMOX1,IGF1,TIMP1,TLR4,CYBB,HK1"]
["REAC","Signaling by Interleukins","REAC:R-HSA-449147",{"v":3.737089726054e-07,"d":"3.74E-07"},446,202,51,10543,"AGER,ALOX5,APP,SDC1,RORA,RPS6KA5,PDCD4,BCL6,FN1,FPR1,HAVCR2,HCK,HGF,SOCS3,STAT3,STAT5A,STAT5B,PSMA1,PTAFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMOX1,ICAM1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,JAK2,LGALS9,LYN,MAPK14,MAPKAPK2,TIMP1,CCL4,CCL5,CCR2,TNFRSF1B,CSF1,CSF1R,CXCL2"]
["REAC","Immune System","REAC:R-HSA-168256",{"v":0.00224667930036131,"d":"2.25E-03"},2139,202,102,10543,"EGFR,ADAM17,AGER,AIM2,ALOX5,APP,MS4A2,SDC1,RORA,RPS6KA5,OLR1,P2RX1,P2RX7,PDCD4,PIK3AP1,BCL6,C5AR1,FCER1G,FN1,FPR1,GBP5,GRN,GSTP1,HAVCR2,HCK,HGF,C3,SIRPA,SLC11A1,CASP4,PJA2,PLD3,SNAP23,SOCS3,STAT3,STAT5A,STAT5B,PRCP,PRKCQ,PSMA1,PTAFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMOX1,ICAM1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,JAK2,KIT,LGALS9,LY86,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,REL,RELB,RICTOR,TCIRG1,TIMP1,TLR1,TLR2,TLR4,CCL4,CCL5,CCR2,CD200,CD28,CD300A,CD47,CD68,CD81,CD96,TNFAIP3,TNFRSF1B,UNC13D,ZBP1,CFH,CIITA,CSF1,CSF1R,CTSC,CTSS,DHX9,CXCL2,CYBB,CYLD,DDX3X"]
["REAC","Cytokine Signaling in Immune system","REAC:R-HSA-1280215",{"v":0.0820414045482182,"d":"8.20E-02"},842,202,59,10543,"EGFR,ADAM17,AGER,ALOX5,APP,SDC1,RORA,RPS6KA5,PDCD4,BCL6,FN1,FPR1,GBP5,HAVCR2,HCK,HGF,SOCS3,STAT3,STAT5A,STAT5B,PRKCQ,PSMA1,PTAFR,PTGS2,PTPN2,NFKB1,NFKBIA,HMGB1,HMOX1,ICAM1,IL16,IL17RA,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RL1,IL2RA,IL33,IRAK2,ITGAM,JAK2,KIT,LGALS9,LYN,MAPK14,MAPKAPK2,RASGRP1,RELB,TIMP1,CCL4,CCL5,CCR2,TNFRSF1B,CIITA,CSF1,CSF1R,CXCL2"]
["REAC","Interleukin-10 signaling","REAC:R-HSA-6783783",{"v":495.381066773945,"d":"4.95E+02"},45,202,15,10543,"FPR1,STAT3,PTAFR,PTGS2,ICAM1,IL18,IL1R1,IL1R2,TIMP1,CCL4,CCL5,CCR2,TNFRSF1B,CSF1,CXCL2"]
["REAC","Innate Immune System","REAC:R-HSA-168249",{"v":59981.8142643608,"d":"6.00E+04"},1073,202,57,10543,"AGER,AIM2,ALOX5,APP,MS4A2,RPS6KA5,OLR1,P2RX1,P2RX7,C5AR1,FCER1G,FPR1,GRN,GSTP1,HCK,C3,SIRPA,SLC11A1,CASP4,PLD3,SNAP23,PRCP,PRKCQ,PSMA1,PTAFR,NFKB1,NFKBIA,HMGB1,IRAK2,ITGAM,LY86,LY96,LYN,MAPK14,MAPKAPK2,RASGRP1,RELB,TCIRG1,TLR1,TLR2,TLR4,CCR2,CD300A,CD47,CD68,CD81,TNFAIP3,TNFRSF1B,UNC13D,ZBP1,CFH,CTSC,CTSS,DHX9,CYBB,CYLD,DDX3X"]
["REAC","Interleukin-1 family signaling","REAC:R-HSA-446652",{"v":1570671396.19697,"d":"1.57E+09"},138,202,17,10543,"AGER,ALOX5,APP,STAT3,PSMA1,PTPN2,NFKB1,NFKBIA,HMGB1,IL18,IL18R1,IL18RAP,IL1R1,IL1R2,IL1RL1,IL33,IRAK2"]
["REAC","Interleukin-4 and Interleukin-13 signaling","REAC:R-HSA-6785807",{"v":3235948040.40734,"d":"3.24E+09"},110,202,15,10543,"ALOX5,RORA,BCL6,FN1,HGF,SOCS3,STAT3,PTGS2,HMOX1,ICAM1,IL18,ITGAM,JAK2,TIMP1,TNFRSF1B"]
["REAC","Toll Like Receptor 4 (TLR4) Cascade","REAC:R-HSA-166016","0.000001893336736279906",126,202,15,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,ITGAM,LY86,LY96,MAPK14,MAPKAPK2,TLR1,TLR2,TLR4"]
["REAC","Platelet activation, signaling and aggregation","REAC:R-HSA-76002","0.000001964822666376327",258,202,21,10543,"ABHD12,MGLL,APP,SERPINE1,PIK3CG,F8,FCER1G,FN1,HGF,PLA2G4A,PRKCA,PRKCQ,PRKCZ,IGF1,LYN,MAPK14,RARRES2,RASGRP1,THBS1,TIMP1,DAGLB"]
["REAC","Neutrophil degranulation","REAC:R-HSA-6798695","0.000001964822666376327",474,202,29,10543,"ALOX5,OLR1,P2RX1,C5AR1,FCER1G,FPR1,GRN,GSTP1,C3,SIRPA,SLC11A1,SNAP23,PRCP,PTAFR,NFKB1,HMGB1,ITGAM,MAPK14,TCIRG1,TLR2,CD300A,CD47,CD68,TNFRSF1B,UNC13D,CTSC,CTSS,CYBB,DDX3X"]
["REAC","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","REAC:R-HSA-166058","0.000001964822666376327",94,202,13,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR1,TLR2,TLR4"]
["REAC","Toll Like Receptor TLR6:TLR2 Cascade","REAC:R-HSA-168188","0.000001964822666376327",94,202,13,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR1,TLR2,TLR4"]
["REAC","Hemostasis","REAC:R-HSA-109582","0.000001964822666376327",657,202,35,10543,"ABHD12,MGLL,APP,SDC1,SERPINE1,OLR1,P2RX1,P2RX7,PDE2A,PDE5A,PIK3CG,F3,F8,FCER1G,FN1,HGF,SIRPA,PLA2G4A,SPN,PRCP,PRKCA,PRKCQ,PRKCZ,IGF1,ITGAM,JAK2,JAM3,LYN,MAPK14,RARRES2,RASGRP1,THBS1,TIMP1,CD47,DAGLB"]
["REAC","Toll-like Receptor Cascades","REAC:R-HSA-168898","0.000002104348614546393",152,202,16,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,ITGAM,LY86,LY96,MAPK14,MAPKAPK2,TLR1,TLR2,TLR4,CTSS"]
["REAC","Toll Like Receptor TLR1:TLR2 Cascade","REAC:R-HSA-168179","0.000002107287631918664",97,202,13,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR1,TLR2,TLR4"]
["REAC","Toll Like Receptor 2 (TLR2) Cascade","REAC:R-HSA-181438","0.000002107287631918664",97,202,13,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR1,TLR2,TLR4"]
["REAC","Growth hormone receptor signaling","REAC:R-HSA-982772","0.000008852144648884261",23,202,7,10543,"ADAM17,SOCS3,STAT3,STAT5A,STAT5B,JAK2,LYN"]
["REAC","Signaling by Leptin","REAC:R-HSA-2586552","0.00001506399725521851",9,202,5,10543,"SOCS3,STAT3,STAT5A,STAT5B,JAK2"]
["REAC","Signaling by KIT in disease","REAC:R-HSA-9669938","0.000022216704916999523",17,202,6,10543,"STAT3,STAT5A,STAT5B,JAK2,KIT,LYN"]
["REAC","Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants","REAC:R-HSA-9670439","0.000022216704916999523",17,202,6,10543,"STAT3,STAT5A,STAT5B,JAK2,KIT,LYN"]
["REAC","Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways","REAC:R-HSA-168643","0.00003832850846719896",55,202,9,10543,"AIM2,APP,P2RX7,CASP4,NFKB1,IRAK2,MAPK14,TNFAIP3,CYLD"]
["REAC","TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation","REAC:R-HSA-975138","0.00004571305267302492",90,202,11,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR4"]
["REAC","MyD88 dependent cascade initiated on endosome","REAC:R-HSA-975155","0.00004687571747262707",91,202,11,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR4"]
["REAC","Toll Like Receptor 7/8 (TLR7/8) Cascade","REAC:R-HSA-168181","0.00004687571747262707",91,202,11,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR4"]
["REAC","Arachidonic acid metabolism","REAC:R-HSA-2142753","0.00005955065532849915",59,202,9,10543,"ABCC1,ALOX5,ALOX5AP,GPX4,PLA2G4A,PTGIS,PTGS1,PTGS2,MAPKAPK2"]
["REAC","MyD88-independent TLR4 cascade ","REAC:R-HSA-166166","0.00006649824453918377",96,202,11,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR4"]
["REAC","Toll Like Receptor 9 (TLR9) Cascade","REAC:R-HSA-168138","0.00006649824453918377",95,202,11,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR4"]
["REAC","TRIF(TICAM1)-mediated TLR4 signaling ","REAC:R-HSA-937061","0.00006649824453918377",96,202,11,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,LY96,MAPK14,MAPKAPK2,TLR4"]
["REAC","Signal Transduction","REAC:R-HSA-162582","0.00006649824453918377",2705,202,82,10543,"MECOM,EDNRA,EDNRB,EGFR,ELF3,ABHD12,ABR,ADAM17,MGLL,APOE,APP,SDC1,SERPINE1,RPS6KA5,NOTCH1,NOTCH2,NR1H3,AXL,PDE2A,PIK3AP1,PIK3CG,BCR,C5AR1,F3,FN1,FPR1,FPR3,HDAC9,HGF,C3,CALCRL,CAMK4,PLA2G4A,PPARD,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PRKCA,PRKCQ,PRKCZ,PSMA1,PTAFR,PTGDR,PTGFR,PTPN2,NFKB1,NFKBIA,IGF1,IL1RL1,IL2RA,IL33,JAK2,KIT,LDLR,LPL,LRRK2,LYN,MAPK14,MAPKAPK2,RASGRP1,RBPJ,RICTOR,TCIRG1,THBS1,CCL4,CCL5,CCR2,CD28,CDH5,TNFAIP3,VPS35,CMKLR1,CNR2,CTNNBIP1,CX3CL1,CXCL2,CYBB,CYLD,CYSLTR1,DAGLB"]
["REAC","Diseases of Immune System","REAC:R-HSA-5260271","0.00013499937096469493",24,202,6,10543,"NFKB1,NFKBIA,LY96,TLR1,TLR2,TLR4"]
["REAC","Diseases associated with the TLR signaling cascade","REAC:R-HSA-5602358","0.00013499937096469493",24,202,6,10543,"NFKB1,NFKBIA,LY96,TLR1,TLR2,TLR4"]
["REAC","Erythropoietin activates STAT5","REAC:R-HSA-9027283","0.00013499937096469493",7,202,4,10543,"STAT5A,STAT5B,JAK2,LYN"]
["REAC","Signaling by Receptor Tyrosine Kinases","REAC:R-HSA-9006934","0.0001675385035757034",485,202,25,10543,"EGFR,ADAM17,APOE,RPS6KA5,AXL,F3,FN1,HGF,STAT3,STAT5A,STAT5B,PRKCA,PRKCZ,PTPN2,IGF1,JAK2,KIT,LYN,MAPK14,MAPKAPK2,RICTOR,TCIRG1,THBS1,CDH5,CYBB"]
["REAC","Signaling by SCF-KIT","REAC:R-HSA-1433557","0.0001785427823265179",38,202,7,10543,"STAT3,STAT5A,STAT5B,PRKCA,JAK2,KIT,LYN"]
["REAC","Interleukin-18 signaling","REAC:R-HSA-9012546","0.00022960491576810442",8,202,4,10543,"ALOX5,IL18,IL18R1,IL18RAP"]
["REAC","Interleukin-2 family signaling","REAC:R-HSA-451927","0.0004645290911399472",44,202,7,10543,"HAVCR2,STAT3,STAT5A,STAT5B,IL2RA,JAK2,LGALS9"]
["REAC","Regulation of TLR by endogenous ligand","REAC:R-HSA-5686938","0.0005783316675970617",19,202,5,10543,"HMGB1,LY96,TLR1,TLR2,TLR4"]
["REAC","MyD88 deficiency (TLR2/4)","REAC:R-HSA-5602498","0.0006155544230522928",10,202,4,10543,"LY96,TLR1,TLR2,TLR4"]
["REAC","TAK1 activates NFkB by phosphorylation and activation of IKKs complex","REAC:R-HSA-445989","0.0006562771995611955",32,202,6,10543,"AGER,APP,NFKB1,NFKBIA,HMGB1,IRAK2"]
["REAC","Toll Like Receptor 10 (TLR10) Cascade","REAC:R-HSA-168142","0.000687063603516943",84,202,9,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,MAPK14,MAPKAPK2"]
["REAC","MyD88 cascade initiated on plasma membrane","REAC:R-HSA-975871","0.000687063603516943",84,202,9,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,MAPK14,MAPKAPK2"]
["REAC","Toll Like Receptor 5 (TLR5) Cascade","REAC:R-HSA-168176","0.000687063603516943",84,202,9,10543,"AGER,APP,RPS6KA5,NFKB1,NFKBIA,HMGB1,IRAK2,MAPK14,MAPKAPK2"]
["REAC","IRAK4 deficiency (TLR2/4)","REAC:R-HSA-5603041","0.0008420185767770724",11,202,4,10543,"LY96,TLR1,TLR2,TLR4"]
["WP","Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway","WP:WP2203","0.000004502487851926229",47,184,11,7581,"HCK,STAT3,STAT5A,STAT5B,NFKB1,NFKBIA,IL2RA,JAK2,LYN,MAPK14,RELB"]
["WP","Oncostatin M Signaling Pathway","WP:WP2374","0.000005898229500871943",66,184,12,7581,"SERPINE1,SOCS3,STAT3,STAT5B,PRKCA,NFKB1,NFKBIA,JAK2,LDLR,MAPK14,RICTOR,CEBPB"]
["WP","AGE/RAGE pathway","WP:WP2324","0.000005898229500871943",66,184,12,7581,"EGFR,AGER,PLA2G4A,STAT3,STAT5A,STAT5B,PRKCA,PRKCZ,NFKB1,NFKBIA,JAK2,MAPK14"]
["WP","IL-18 signaling pathway","WP:WP4754","0.000005898229500871943",279,184,24,7581,"NR1H3,FN1,GRN,PLA2G7,SOCS3,PRKCA,PTGS2,NFKB1,NFKBIA,HMOX1,ICAM1,IL18,IL18R1,IL18RAP,IL2RA,REL,TGM2,TIMP1,CCL4,CCL5,CD81,TNFAIP3,CEBPB,CXCL2"]
["WP","IL1 and megakaryocytes in obesity","WP:WP2865","0.0000068073044357195775",25,184,8,7581,"PLA2G7,NFKB1,ICAM1,IL18,IL1R1,TIMP1,TLR1,TLR2"]
["WP","Adipogenesis","WP:WP236","0.000039709062249399505",131,184,15,7581,"SERPINE1,RORA,NR1H3,PPARA,PPARD,PPARG,SOCS3,STAT3,STAT5A,STAT5B,PTGIS,IGF1,LPL,TGFB1,CEBPB"]
["WP","Prostaglandin Synthesis and Regulation","WP:WP98","0.0000620081298850667",45,184,9,7581,"EDNRA,EDNRB,PLA2G4A,PPARG,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2"]
["WP","Lung fibrosis","WP:WP3624","0.00012595461270639523",63,184,10,7581,"HGF,HMOX1,IGF1,TGFB1,TIMP1,CCL4,CCL5,CCR2,CEBPB,CXCL2"]
["WP","Gastrin Signaling Pathway","WP:WP4659","0.00016260637586509367",114,184,13,7581,"EGFR,SERPINE1,PPARG,STAT3,PRKCA,PRKCQ,PRKD1,PTGS2,NFKB1,NFKBIA,JAK2,KIT,MAPK14"]
["WP","Eicosanoid metabolism via Cyclo Oxygenases (COX)","WP:WP4719","0.00022967664390352908",30,184,7,7581,"PLA2G4A,PPARD,PTGDR,PTGFR,PTGIS,PTGS1,PTGS2"]
["WP","IL-4 Signaling Pathway","WP:WP395","0.00022967664390352908",55,184,9,7581,"SOCS3,STAT3,STAT5A,STAT5B,NFKB1,NFKBIA,JAK2,MAPK14,CEBPB"]
["WP","IL-1 signaling pathway","WP:WP195","0.0002856881958699611",57,184,9,7581,"PRKCZ,NFKB1,NFKBIA,IL1R1,IL1RAP,IRAK2,MAPK14,MAPKAPK2,REL"]
["WP","White fat cell differentiation","WP:WP4149","0.00036918116929483076",33,184,7,7581,"MECOM,RORA,NR1H3,PPARG,STAT5A,STAT5B,CEBPB"]
["WP","Prolactin Signaling Pathway","WP:WP2037","0.00040902432642607445",76,184,10,7581,"PIK3CG,SIRPA,SOCS3,STAT3,STAT5A,STAT5B,NFKB1,NFKBIA,JAK2,MAPK14"]
["WP","Signal transduction through IL1R","WP:WP4496","0.0004833739319515385",35,184,7,7581,"NFKB1,NFKBIA,IL1R1,IL1RAP,IRAK2,MAPK14,TGFB1"]
["WP","IL-3 Signaling Pathway","WP:WP286","0.0005387092994155189",49,184,8,7581,"ENPP3,HCK,STAT3,STAT5A,STAT5B,JAK2,LYN,TGFB1"]
["WP","Structural Pathway of Interleukin 1 (IL-1)","WP:WP2637","0.0005912119640785614",50,184,8,7581,"RPS6KA5,NFKB1,NFKBIA,IL1R1,IL1RAP,IRAK2,MAPK14,MAPKAPK2"]
["WP","Spinal Cord Injury","WP:WP2431","0.000635519029104756",118,184,12,7581,"EGFR,GJA1,SLIT2,PRKCA,PTGS2,ICAM1,IL1R1,TGFB1,TLR4,CCR2,CD47,CXCL2"]
["WP","Eicosanoid Synthesis","WP:WP167","0.0006597194801550606",26,184,6,7581,"ALOX5,ALOX5AP,PLA2G4A,PTGIS,PTGS1,PTGS2"]
["WP","RAC1/PAK1/p38/MMP2 Pathway","WP:WP3303","0.0007664476155001987",69,184,9,7581,"EGFR,FN1,STAT3,STAT5A,STAT5B,NFKB1,NFKBIA,MAPK14,TNIP1"]
["WP","Platelet-mediated interactions with vascular and circulating cells","WP:WP4462","0.0007664476155001987",17,184,5,7581,"ICAM1,TGFB1,TLR2,TLR4,CCL5"]
["WP","Supression of HMGB1 mediated inflammation by THBD","WP:WP4479","0.0007664476155001987",9,184,4,7581,"AGER,NFKB1,NFKBIA,HMGB1"]
["WP","Regulation of toll-like receptor signaling pathway","WP:WP1449","0.0008799959996533102",145,184,13,7581,"PIK3CG,NFKB1,NFKBIA,IRAK2,LY96,MAPK14,TLR1,TLR2,TLR4,CCL4,CCL5,TNFAIP3,CYLD"]

{"sheet":"ST3","index":2,"n_rows":270,"n_cols":12,"rows_kept":270,"merged":[[1,0,1,10]]}
[]
["Supplementary Table 3. Inflammatory protein-protein interactome network"]
[]
["SUID","display name","GENE_ID","name","Degree",">50%_expression","ALL_NETWORK","HumanProteins_SARSCoV2","GORDON","Inflammatory","Inflammatory_Mas_Gordon","stringdb::description"]
[204,"APP",351,"9606.ENSP00000284981",38,1,1,8,0,1,0,"Amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6); Endogenous ligands"]
[90,"NFKB1",4790,"9606.ENSP00000226574",36,0,1,10,0,1,0,"Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105."]
[157,"STAT3",6774,"9606.ENSP00000264657",34,0,1,1,0,1,0,"Signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity); SH2 domain containing"]
[110,"C3",718,"9606.ENSP00000245907",31,0,1,11,0,1,0,"C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates; C3 and PZP like, alpha-2-macroglobulin domain containing"]
[595,"GNB1",2782,"9606.ENSP00000481878",29,0,1,null,1,0,0,"Guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction."]
[556,"ITGAM",3684,"9606.ENSP00000441691",29,0,1,8,0,1,0,"Integrin, alpha M (complement component 3 receptor 3 subunit); Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity)."]
[335,"FN1",2335,"9606.ENSP00000346839",26,1,1,11,0,1,0,"Fibronectin type III domain containing; Endogenous ligands"]
[394,"GNG5",2787,"9606.ENSP00000359675",25,0,1,null,1,0,0,"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction."]
[412,"PTAFR",5724,"9606.ENSP00000362965",24,0,1,6,0,1,0,"Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system."]
[512,"RHOA",387,"9606.ENSP00000400175",23,0,1,null,1,0,0,"Ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis; Belongs to the small GTPase superfamily. Rho family."]
[474,"ITGB1",3688,"9606.ENSP00000379350",22,0,1,null,1,0,0,"Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen- dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1; CD molecules"]
[448,"JAK2",3717,"9606.ENSP00000371067",22,0,1,5,0,1,0,"Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin."]
[208,"STOM",2040,"9606.ENSP00000286713",20,0,1,null,1,0,0,"Erythrocyte band 7 integral membrane protein; Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity; Belongs to the band 7/mec-2 family."]
[410,"RAB14",51552,"9606.ENSP00000362946",20,0,1,null,1,0,0,"RAB14, member RAS oncogene family; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion; Belongs to the small GTPase superfamily. Rab family."]
[185,"EGFR",1956,"9606.ENSP00000275493",20,1,1,6,0,1,0,"Receptor tyrosine-protein kinase erbB-1; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity)."]
[544,"LYN",4067,"9606.ENSP00000428924",20,1,1,1,0,1,0,"V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down- regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3- kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr- 72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation."]
[115,"SNAP23",8773,"9606.ENSP00000249647",19,0,1,8,0,1,0,"Vesicle-membrane fusion protein SNAP-23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family."]
[596,"CCL4",6351,"9606.ENSP00000482259",19,0,1,6,0,1,0,"Macrophage inflammatory protein 1-beta; Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B; Belongs to the intercrine beta (chemokine CC) family."]
[94,"MAPK14",1432,"9606.ENSP00000229795",18,0,1,7,0,1,0,"Cytokine suppressive anti-inflammatory drug-binding protein; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF- induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14- mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF- kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'."]
[171,"PRKAR2B",5577,"9606.ENSP00000265717",17,0,1,null,1,0,0,"cAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase."]
[239,"RAB8A",4218,"9606.ENSP00000300935",17,0,1,null,1,0,0,"RAB8A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy."]
[260,"PRKACA",5566,"9606.ENSP00000309591",17,0,1,null,1,0,0,"cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B- alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha- difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock."]
[76,"NFKBIA",4792,"9606.ENSP00000216797",17,0,1,5,0,1,0,"Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription."]
[77,"TIMP1",7076,"9606.ENSP00000218388",17,0,1,5,0,1,0,"Tissue inhibitor of metalloproteinases 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors."]
[371,"CD47",961,"9606.ENSP00000355361",17,0,1,5,0,1,0,"Antigenic surface determinant protein OA3; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection; CD molecules"]
[83,"TGFB1",7040,"9606.ENSP00000221930",17,0,1,4,0,1,0,"Transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types; Endogenous ligands"]
[577,"FPR1",2357,"9606.ENSP00000471493",17,0,1,4,0,1,0,"N-formylpeptide chemoattractant receptor; High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system."]
[258,"OLR1",4973,"9606.ENSP00000309124",16,0,1,5,0,1,0,"Oxidized low density lipoprotein (lectin-like) receptor 1; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria; C-type lectin domain containing"]
[433,"CYBB",1536,"9606.ENSP00000367851",16,0,1,5,0,1,0,"Superoxide-generating NADPH oxidase heavy chain subunit; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc."]
[522,"ANO6",196527,"9606.ENSP00000409126",16,0,1,null,1,0,0,"Small-conductance calcium-activated nonselective cation channel; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes; Anoctamins"]
[563,"RAB5C",5878,"9606.ENSP00000447053",16,0,1,null,1,0,0,"RAB5C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity); RAB, member RAS oncogene GTPases"]
[84,"HGF",3082,"9606.ENSP00000222390",16,0,1,3,0,1,0,"Hepatocyte growth factor (hepapoietin A; scatter factor); Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization; Deafness associated genes"]
[215,"FCER1G",2207,"9606.ENSP00000289902",16,0,1,3,0,1,0,"Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin; Belongs to the CD3Z/FCER1G family."]
[422,"TNFRSF1B",7133,"9606.ENSP00000365435",15,0,1,6,0,1,0,"Tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity; CD molecules"]
[341,"AKAP9",10142,"9606.ENSP00000348573",15,0,1,null,1,0,0,"Centrosome- and Golgi-localized PKN-associated protein; Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Recruited to the Golgi apparatus by GM130/GOLGA2 and is required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Forms a complex with PDE4DIP: the complex recruits CAMSAP2 to the Golgi apparatus, leading to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement; A-kinase anchoring proteins"]
[359,"F8",2157,"9606.ENSP00000353393",14,0,1,5,0,1,0,"Coagulation factor VIII, procoagulant component; Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa; Belongs to the multicopper oxidase family."]
[134,"GGH",8836,"9606.ENSP00000260118",14,0,1,null,1,0,0,"Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates; Belongs to the peptidase C26 family."]
[135,"THBS1",7057,"9606.ENSP00000260356",14,0,1,3,0,1,0,"Thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity)."]
[579,"CCL5",6352,"9606.ENSP00000474412",14,0,1,2,0,1,0,"Eosinophil chemotactic cytokine; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1- infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1- 68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells; Belongs to the intercrine beta (chemokine CC) family."]
[92,"CTSC",1075,"9606.ENSP00000227266",13,0,1,9,0,1,0,"Dipeptidyl peptidase 1; Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII."]
[454,"HSPD1",3329,"9606.ENSP00000373620",13,0,1,9,0,1,0,"60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable)."]
[189,"NOTCH1",4851,"9606.ENSP00000277541",13,0,1,6,0,1,0,"Translocation-associated notch protein TAN-1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO); Ankyrin repeat domain containing"]
[75,"RBX1",9978,"9606.ENSP00000216225",13,0,1,null,1,0,0,"Ring-box 1, E3 ubiquitin protein ligase; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription- coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM."]
[500,"RAB1A",5861,"9606.ENSP00000387286",13,0,1,null,1,0,0,"RAB1A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport."]
[521,"PRKCA",5578,"9606.ENSP00000408695",13,1,1,3,0,1,0,"Protein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42. Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)- dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B- ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF- kappa-B-induced genes, through IL1A-dependent induction of NF- kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O- tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription; C2 domain containing protein kinases"]
[217,"CCR2",729230,"9606.ENSP00000292301",13,0,1,2,0,1,0,"Monocyte chemoattractant protein 1 receptor; Receptor for the CCL2, CCL7 and CCL13 chemokines. Receptor for the beta-defensin DEFB106A/DEFB106B. Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable)."]
[543,"CXCL2",2920,"9606.ENSP00000427279",13,0,1,2,0,1,0,"Macrophage inflammatory protein 2-alpha; Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity."]
[446,"SDC1",6382,"9606.ENSP00000370542",12,0,1,5,0,1,0,"Syndecan 1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP."]
[117,"APOE",348,"9606.ENSP00000252486",12,0,1,4,0,1,0,"Apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues; Apolipoproteins"]
[295,"CSF1",1435,"9606.ENSP00000327513",12,0,1,4,0,1,0,"Colony stimulating factor 1 (macrophage); Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance."]
[293,"FBN1",2200,"9606.ENSP00000325527",12,0,1,null,1,0,0,"Fibrillin 1; Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell- surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca2+ signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction has an important role in the assembly of microfibrils."]
[329,"PTGES2",80142,"9606.ENSP00000345341",12,0,1,null,1,0,0,"Membrane-associated prostaglandin E synthase-2; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2); Glutaredoxin domain containing"]
[97,"SLC11A1",6556,"9606.ENSP00000233202",12,1,1,3,0,1,0,"Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes; Solute carriers"]
[319,"STAT5A",6776,"9606.ENSP00000341208",12,0,1,0,0,1,0,"Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation; SH2 domain containing"]
[358,"CD300A",11314,"9606.ENSP00000353259",12,0,1,3,0,1,0,"Immunoglobulin superfamily member 12; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6; Belongs to the CD300 family."]
[484,"SIRPA",140885,"9606.ENSP00000382941",12,0,1,3,0,1,0,"Brain Ig-like molecule with tyrosine-based activation motifs; Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells; C1-set domain containing"]
[64,"CX3CL1",6376,"9606.ENSP00000006053",12,0,1,2,0,1,0,"Chemokine (C-X3-C motif) ligand 1; Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1. Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium."]
[320,"FPR3",2359,"9606.ENSP00000341821",12,0,1,2,0,1,0,"Formyl peptide receptor-like 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system."]
[337,"C5AR1",728,"9606.ENSP00000347197",12,0,1,2,0,1,0,"C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production; CD molecules"]
[417,"CNR2",1269,"9606.ENSP00000363596",12,0,1,2,0,1,0,"Cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis."]
[299,"SOCS3",9021,"9606.ENSP00000330341",11,0,1,5,0,1,0,"Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity); SH2 domain containing"]
[88,"P2RX1",5023,"9606.ENSP00000225538",11,0,1,4,0,1,0,"Purinergic receptor P2X, ligand-gated ion channel, 1; Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity); Purinergic receptors P2X"]
[276,"EDNRA",1909,"9606.ENSP00000315011",11,0,1,4,0,1,0,"Endothelin receptor type A; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3."]
[324,"CDK5RAP2",55755,"9606.ENSP00000343818",11,0,1,null,1,0,0,"CDK5 regulatory subunit associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of a gamma- tubulin ring complex onto centrosomes."]
[219,"STAT5B",6777,"9606.ENSP00000293328",11,0,1,0,0,1,0,"Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation."]
[242,"IGF1",3479,"9606.ENSP00000302665",11,0,1,1,0,1,0,"Insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down- stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1."]
[330,"HMGB1",3146,"9606.ENSP00000345347",11,0,1,1,0,1,0,"High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP; Canonical high mobility group"]
[575,"RPS19",6223,"9606.ENSP00000470972",10,0,1,10,0,1,0,"Small ribosomal subunit protein eS19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family."]
[203,"LY96",23643,"9606.ENSP00000284818",10,0,1,3,0,1,0,"Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS."]
[415,"TLR4",7099,"9606.ENSP00000363089",10,0,1,3,0,1,0,"Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor."]
[129,"CEP135",9662,"9606.ENSP00000257287",10,0,1,null,1,0,0,"Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole; Belongs to the CEP135/TSGA10 family."]
[131,"RIPK1",8737,"9606.ENSP00000259808",10,0,1,null,1,0,0,"Receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex."]
[177,"SLC27A2",11001,"9606.ENSP00000267842",10,0,1,null,1,0,0,"Solute carrier family 27 (fatty acid transporter), member 2; Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family."]
[191,"NINL",22981,"9606.ENSP00000278886",10,0,1,null,1,0,0,"Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis; EF-hand domain containing"]
[309,"SLC44A2",57153,"9606.ENSP00000336888",10,0,1,null,1,0,0,"Solute carrier family 44 (choline transporter), member 2; Isoform 1, but not isoform 3, exhibits some choline transporter activity; Solute carriers"]
[354,"PCNT",5116,"9606.ENSP00000352572",10,0,1,null,1,0,0,"Pericentrin-B; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome."]
[411,"CNTRL",11064,"9606.ENSP00000362962",10,0,1,null,1,0,0,"Centrosomal protein of 110 kDa; Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle- mediated abscission."]
[86,"SERPINE1",5054,"9606.ENSP00000223095",10,0,1,2,0,1,0,"Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis; Serpin peptidase inhibitors"]
[378,"DHX9",1660,"9606.ENSP00000356520",9,0,1,7,0,1,0,"DEAH (Asp-Glu-Ala-His) box helicase 9; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo- nucleotide triphosphates (NTPs). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex- helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes. Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA. Binds also to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A. Plays a role in DNA replication at origins of replication and cell cycle progression. Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1. Binds to the CDKN2A promoter. Plays several roles in post-transcriptional regulation of gene expression. In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes. As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Acts also as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition. Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA. Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability. Plays a role in mRNA translation. Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs. Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation. Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process. Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection. This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis. Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus; Belongs to the DEAD box helicase family. DEAH subfamily."]
[428,"EDNRB",1910,"9606.ENSP00000366416",9,0,1,3,0,1,0,"Endothelin receptor non-selective type; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily."]
[432,"PRKCZ",5590,"9606.ENSP00000367830",9,1,1,3,0,1,0,"Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro."]
[78,"GLA",2717,"9606.ENSP00000218516",9,0,1,null,1,0,0,"Alpha-D-galactoside galactohydrolase; Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family."]
[91,"WFS1",7466,"9606.ENSP00000226760",9,0,1,null,1,0,0,"Wolfram syndrome 1 (wolframin); Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store; Deafness associated genes"]
[143,"TUBGCP3",10426,"9606.ENSP00000261965",9,0,1,null,1,0,0,"Tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome."]
[147,"RAB2A",5862,"9606.ENSP00000262646",9,0,1,null,1,0,0,"RAB2A, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases"]
[159,"RAB10",10890,"9606.ENSP00000264710",9,0,1,null,1,0,0,"RAB10, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion; RAB, member RAS oncogene GTPases"]
[165,"STC2",8614,"9606.ENSP00000265087",9,0,1,null,1,0,0,"Stanniocalcin-related protein; Has an anti-hypocalcemic action on calcium and phosphate homeostasis; Belongs to the stanniocalcin family."]
[168,"PRKAR2A",5576,"9606.ENSP00000265563",9,0,1,null,1,0,0,"cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase."]
[178,"MFGE8",4240,"9606.ENSP00000268150",9,0,1,null,1,0,0,"Milk fat globule-EGF factor 8 protein; Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication."]
[218,"AP2M1",1173,"9606.ENSP00000292807",9,0,1,null,1,0,0,"Clathrin assembly protein complex 2 mu medium chain; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X- X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane- associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity)."]
[232,"ARF6",382,"9606.ENSP00000298316",9,0,1,null,1,0,0,"ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase; ARF GTPase family"]
[372,"SCCPDH",51097,"9606.ENSP00000355467",9,0,1,null,1,0,0,"Saccharopine dehydrogenase-like oxidoreductase; Saccharopine dehydrogenase; Belongs to the saccharopine dehydrogenase family."]
[126,"IRAK2",3656,"9606.ENSP00000256458",9,0,1,0,0,1,0,"Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization."]
[561,"TUBGCP2",10844,"9606.ENSP00000446093",9,0,1,null,1,0,0,"Tubulin, gamma complex associated protein 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome."]
[570,"RPL36",25873,"9606.ENSP00000464342",9,0,1,null,1,0,0,"Large ribosomal subunit protein eL36; Component of the large ribosomal subunit."]
[246,"BCR",613,"9606.ENSP00000303507",9,0,1,1,0,1,0,"Breakpoint cluster region protein; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity; C2 domain containing"]
[267,"PTPN2",5771,"9606.ENSP00000311857",9,0,1,1,0,1,0,"Protein tyrosine phosphatase, non-receptor type 2; Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF- stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA."]
[441,"IL2RA",3559,"9606.ENSP00000369293",9,0,1,1,0,1,0,"Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells; CD molecules"]
[66,"GRN",2896,"9606.ENSP00000053867",8,0,1,5,0,1,0,"Proepithelin; Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling."]
[72,"UNC13D",201294,"9606.ENSP00000207549",8,0,1,5,0,1,0,"Unc-13 homolog D (C. elegans); Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells; UNC13 homologs"]
[327,"RBPJ",3516,"9606.ENSP00000345206",8,1,1,4,0,1,0,"Recombination signal binding protein for immunoglobulin kappa J region; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen); Belongs to the Su(H) family."]
[395,"PTGFR",5737,"9606.ENSP00000359793",8,0,1,3,0,1,0,"Prostaglandin F2-alpha receptor; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost."]
[526,"PSMA1",5682,"9606.ENSP00000414359",8,0,1,3,0,1,0,"Proteasome (prosome, macropain) subunit, alpha type, 1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)."]
[584,"CYSLTR1",10800,"9606.ENSP00000478492",8,0,1,3,0,1,0,"Cysteinyl leukotriene D4 receptor; Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4."]
[73,"PSMD8",5714,"9606.ENSP00000215071",8,0,1,null,1,0,0,"Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair."]
[164,"RAB7A",7879,"9606.ENSP00000265062",8,0,1,null,1,0,0,"RAB7A, member RAS oncogene family; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF- EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan; Belongs to the small GTPase superfamily. Rab family."]
[226,"F2RL1",2150,"9606.ENSP00000296677",8,0,1,null,1,0,0,"Coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E- cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders."]
[298,"TBK1",29110,"9606.ENSP00000329967",8,0,1,null,1,0,0,"Serine/threonine-protein kinase TBK1; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser- 177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein."]
[360,"CYB5R3",1727,"9606.ENSP00000354468",8,0,1,null,1,0,0,"NADH-cytochrome b5 reductase 3; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction."]
[559,"CUL2",8453,"9606.ENSP00000444856",8,0,1,null,1,0,0,"Cullin 2; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF); Cullins"]
[214,"KIT",3815,"9606.ENSP00000288135",8,1,1,0,0,1,0,"V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1."]
[564,"NPC2",10577,"9606.ENSP00000451112",8,0,1,null,1,0,0,"Niemann-Pick disease type C2 protein; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport."]
[560,"HCK",3055,"9606.ENSP00000444986",8,0,1,0,0,1,0,"HCK proto-oncogene, Src family tyrosine kinase; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS; SH2 domain containing"]
[212,"PPARG",5468,"9606.ENSP00000287820",8,0,1,1,0,1,0,"Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity); Nuclear hormone receptors"]
[261,"LPL",4023,"9606.ENSP00000309757",8,0,1,1,0,1,0,"Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family."]
[351,"PIK3CG",5294,"9606.ENSP00000352121",7,0,1,3,0,1,0,"Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin- based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B- lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis; Belongs to the PI3/PI4-kinase family."]
[149,"PRKCQ",5588,"9606.ENSP00000263125",7,0,1,2,0,1,0,"Protein kinase C theta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non- canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1."]
[221,"REL",5966,"9606.ENSP00000295025",7,0,1,2,0,1,0,"V-rel avian reticuloendotheliosis viral oncogene homolog; Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator."]
[296,"AP2A2",161,"9606.ENSP00000327694",7,0,1,null,1,0,0,"Clathrin assembly protein complex 2 alpha-C large chain; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C- terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity); Clathrin/coatomer adaptor, adaptin-like, N-terminal domain containing"]
[133,"TLR2",7097,"9606.ENSP00000260010",7,0,1,0,0,1,0,"Toll/interleukin-1 receptor-like protein 4; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4. MAPK activation in response to bacterial peptidoglycan also occurs via this receptor. Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen. M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression. Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides. Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity)."]
[583,"RAB18",22931,"9606.ENSP00000478479",7,0,1,null,1,0,0,"RAB18, member RAS oncogene family"]
[249,"CEBPB",1051,"9606.ENSP00000305422",7,0,1,1,0,1,0,"CCAAT/enhancer binding protein (C/EBP), beta; Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation. Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity); Belongs to the bZIP family. C/EBP subfamily."]
[363,"PJA2",9867,"9606.ENSP00000354775",6,0,1,5,0,1,0,"Praja ring finger 2, E3 ubiquitin protein ligase; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes; Ring finger proteins"]
[520,"HDAC9",9734,"9606.ENSP00000408617",6,1,1,4,0,1,0,"MEF2-interacting transcription repressor MITR; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription; Belongs to the histone deacetylase family. HD type 2 subfamily."]
[127,"NOTCH2",4853,"9606.ENSP00000256646",6,0,1,3,0,1,0,"Neurogenic locus notch homolog protein 2; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells."]
[112,"FBXL12",54850,"9606.ENSP00000247977",6,0,1,null,1,0,0,"F-box and leucine-rich repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins"]
[162,"GRPEL1",80273,"9606.ENSP00000264954",6,0,1,null,1,0,0,"GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins."]
[230,"SLU7",10569,"9606.ENSP00000297151",6,0,1,null,1,0,0,"SLU7 splicing factor homolog (S. cerevisiae); Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation; Spliceosomal C complex"]
[271,"PABPC1",26986,"9606.ENSP00000313007",6,0,1,null,1,0,0,"poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability. Positively regulates the replication of dengue virus (DENV)."]
[272,"GORASP1",64689,"9606.ENSP00000313869",6,0,1,null,1,0,0,"Golgi reassembly-stacking protein of 65 kDa; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes; PDZ domain containing"]
[318,"GTF2F2",2963,"9606.ENSP00000340823",6,0,1,null,1,0,0,"General transcription factor IIF, polypeptide 2, 30kDa; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA- helicase activity."]
[322,"RNF41",10193,"9606.ENSP00000342755",6,0,1,null,1,0,0,"Ring finger protein 41, E3 ubiquitin protein ligase; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control."]
[481,"HECTD1",25831,"9606.ENSP00000382269",6,0,1,null,1,0,0,"HECT domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure; Belongs to the UPL family. K-HECT subfamily."]
[525,"BCS1L",617,"9606.ENSP00000413908",6,0,1,null,1,0,0,"BC1 (ubiquinol-cytochrome c reductase) synthesis-like; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex; AAA ATPases"]
[527,"GOLGA2",2801,"9606.ENSP00000416097",6,0,1,null,1,0,0,"130 kDa cis-Golgi matrix protein; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization. Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin- alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle. Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization. Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins."]
[547,"HDAC2",3066,"9606.ENSP00000430432",6,0,1,null,1,0,0,"Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A."]
[82,"RELB",5971,"9606.ENSP00000221452",6,0,1,1,0,1,0,"V-rel avian reticuloendotheliosis viral oncogene homolog B; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function."]
[200,"ITGB6",3694,"9606.ENSP00000283249",5,0,1,3,0,1,0,"Integrin, beta 6; Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1."]
[245,"PTGDR",5729,"9606.ENSP00000303424",5,0,1,3,0,1,0,"Prostaglandin D2 receptor (DP); Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity)."]
[568,"LDLR",3949,"9606.ENSP00000454071",5,0,1,3,0,1,0,"Low density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family."]
[116,"CD68",968,"9606.ENSP00000250092",5,0,1,2,0,1,0,"CD68 molecule; Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells; Belongs to the LAMP family."]
[63,"RALA",5898,"9606.ENSP00000005257",5,0,1,null,1,0,0,"V-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage- independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody; RAS type GTPase family"]
[124,"AP3B1",8546,"9606.ENSP00000255194",5,0,1,null,1,0,0,"Clathrin assembly protein complex 3 beta-1 large chain; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals."]
[128,"TIMM10",26519,"9606.ENSP00000257245",5,0,1,null,1,0,0,"Translocase of inner mitochondrial membrane 10 homolog (yeast); Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space; Belongs to the small Tim family."]
[146,"SLC9A3R1",9368,"9606.ENSP00000262613",5,0,1,null,1,0,0,"Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa; PDZ domain containing"]
[244,"LMAN2",10960,"9606.ENSP00000303366",5,0,1,null,1,0,0,"Vesicular integral-membrane protein VIP36; Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity)."]
[160,"ICAM1",3383,"9606.ENSP00000264832",5,0,1,0,0,1,0,"Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation; CD molecules"]
[207,"CSF1R",1436,"9606.ENSP00000286301",5,0,1,0,0,1,0,"Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP- 1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor."]
[275,"IL1RAP",3556,"9606.ENSP00000314807",5,0,1,0,0,1,0,"Interleukin 1 receptor accessory protein; Immunoglobulin like domain containing"]
[453,"DNAJC19",131118,"9606.ENSP00000372005",5,0,1,null,1,0,0,"Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity); Belongs to the TIM14 family."]
[366,"TLR1",7096,"9606.ENSP00000354932",5,0,1,0,0,1,0,"Toll/interleukin-1 receptor-like protein; Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response."]
[511,"MOV10",4343,"9606.ENSP00000399797",5,0,1,null,1,0,0,"Moloney leukemia virus 10 protein; Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC; Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily."]
[376,"PLA2G4A",5321,"9606.ENSP00000356436",5,0,1,0,0,1,0,"Phospholipase A2, group IVA (cytosolic, calcium-dependent); Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response; C2 domain containing phospholipases"]
[291,"CD28",940,"9606.ENSP00000324890",5,0,1,1,0,1,0,"T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells."]
[313,"SNCA",6622,"9606.ENSP00000338345",5,0,1,1,0,1,0,"Synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation; Parkinson disease associated genes"]
[377,"PTGS2",5743,"9606.ENSP00000356438",5,0,1,1,0,1,0,"Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis; Belongs to the prostaglandin G/H synthase family."]
[416,"ALOX5",240,"9606.ENSP00000363512",5,0,1,1,0,1,0,"Arachidonate 5-lipoxygenase; Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes; Belongs to the lipoxygenase family."]
[499,"IL18R1",8809,"9606.ENSP00000387211",5,1,1,1,0,1,0,"CD218 antigen-like family member A; Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity); CD molecules"]
[382,"CDK19",23097,"9606.ENSP00000357907",4,0,1,4,0,1,0,"Cell division cycle 2-like protein kinase 6; Cyclin dependent kinase 19; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."]
[348,"EPHA2",1969,"9606.ENSP00000351209",4,0,1,2,0,1,0,"Tyrosine-protein kinase receptor ECK; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis."]
[397,"ZBP1",81030,"9606.ENSP00000360215",4,0,1,2,0,1,0,"Tumor stroma and activated macrophage protein DLM-1; Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity)."]
[462,"PRCP",5547,"9606.ENSP00000377055",4,0,1,2,0,1,0,"Prolylcarboxypeptidase (angiotensinase C); Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH; M14 carboxypeptidases"]
[588,"RPS6KA5",9252,"9606.ENSP00000479667",4,0,1,2,0,1,0,"Nuclear mitogen- and stress-activated protein kinase 1; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto- oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro- inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser- 107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity."]
[593,"TNFAIP3",7128,"9606.ENSP00000481570",4,0,1,2,0,1,0,"Tumor necrosis factor, alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS- induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages; OTU domain containing"]
[114,"PMPCB",9512,"9606.ENSP00000249269",4,0,1,null,1,0,0,"Mitochondrial-processing peptidase subunit beta; Cleaves presequences (transit peptides) from mitochondrial protein precursors; M16 metallopeptidases"]
[121,"NUP210",23225,"9606.ENSP00000254508",4,0,1,null,1,0,0,"Nuclear envelope pore membrane protein POM 210; Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity; Nucleoporins"]
[206,"PPIL3",53938,"9606.ENSP00000286175",4,0,1,null,1,0,0,"Peptidylprolyl isomerase (cyclophilin)-like 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylprolyl isomerases"]
[321,"SRP72",6731,"9606.ENSP00000342181",4,0,1,null,1,0,0,"Signal recognition particle 72 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function; Belongs to the SRP72 family."]
[352,"NUP214",8021,"9606.ENSP00000352400",4,0,1,null,1,0,0,"Nuclear pore complex protein Nup214; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex; Nucleoporins"]
[399,"PMPCA",23203,"9606.ENSP00000360782",4,0,1,null,1,0,0,"Mitochondrial-processing peptidase subunit alpha; Cleaves presequences (transit peptides) from mitochondrial protein precursors; Belongs to the peptidase M16 family."]
[125,"FABP4",2167,"9606.ENSP00000256104",4,0,1,0,0,1,0,"Adipocyte-type fatty acid-binding protein; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family."]
[419,"NEU1",4758,"9606.ENSP00000364782",4,0,1,null,1,0,0,"Sialidase 1 (lysosomal sialidase); Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage."]
[194,"IL18",3606,"9606.ENSP00000280357",4,0,1,0,0,1,0,"Interferon gamma-inducing factor; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells; Belongs to the IL-1 family."]
[469,"TIMM9",26520,"9606.ENSP00000378588",4,0,1,null,1,0,0,"Translocase of inner mitochondrial membrane 9 homolog (yeast); Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space; Belongs to the small Tim family."]
[262,"ADAM17",6868,"9606.ENSP00000309968",4,0,1,0,0,1,0,"Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2; ADAM metallopeptidase domain containing"]
[418,"AGER",177,"9606.ENSP00000364210",4,0,1,0,0,1,0,"Advanced glycosylation end product-specific receptor; Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides; C2-set domain containing"]
[523,"MARK3",4140,"9606.ENSP00000411397",4,0,1,null,1,0,0,"MAP/microtubule affinity-regulating kinase 3; Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1."]
[540,"SRP19",6728,"9606.ENSP00000424870",4,0,1,null,1,0,0,"Signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP."]
[555,"TIMM8B",26521,"9606.ENSP00000438455",4,0,1,null,1,0,0,"Translocase of inner mitochondrial membrane 8 homolog B (yeast); Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)."]
[565,"SRP54",6729,"9606.ENSP00000451818",4,0,1,null,1,0,0,"Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)."]
[576,"NUP62",23636,"9606.ENSP00000471191",4,0,1,null,1,0,0,"Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown; Nucleoporins"]
[488,"PPARA",5465,"9606.ENSP00000385523",4,0,1,0,0,1,0,"Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2; Belongs to the nuclear hormone receptor family. NR1 subfamily."]
[494,"IL1R1",3554,"9606.ENSP00000386380",4,1,1,0,0,1,0,"CD121 antigen-like family member A; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex."]
[496,"CALCRL",10203,"9606.ENSP00000386972",3,1,1,2,0,1,0,"Calcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase."]
[144,"ERP44",23071,"9606.ENSP00000262455",3,0,1,null,1,0,0,"Endoplasmic reticulum resident protein 44; Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum."]
[172,"EIF4H",7458,"9606.ENSP00000265753",3,0,1,null,1,0,0,"Williams-Beuren syndrome chromosomal region 1 protein; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA; RNA binding motif containing"]
[108,"PTGIS",5740,"9606.ENSP00000244043",3,0,1,1,0,1,0,"Prostaglandin I2 (prostacyclin) synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Cytochrome P450 family 8"]
[154,"IL18RAP",8807,"9606.ENSP00000264260",3,0,1,0,0,1,0,"Interleukin-18 receptor accessory protein-like; Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation."]
[192,"MS4A2",2206,"9606.ENSP00000278888",3,0,1,0,0,1,0,"High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy; Belongs to the MS4A family."]
[233,"LRRK2",120892,"9606.ENSP00000298910",3,1,1,0,0,1,0,"Leucine-rich repeat serine/threonine-protein kinase 2; Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family."]
[424,"TLE1",7088,"9606.ENSP00000365682",3,0,1,null,1,0,0,"Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG; Belongs to the WD repeat Groucho/TLE family."]
[445,"CWC27",10283,"9606.ENSP00000370460",3,0,1,null,1,0,0,"CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins; Belongs to the cyclophilin-type PPIase family."]
[485,"RDX",5962,"9606.ENSP00000384136",3,0,1,null,1,0,0,"Radixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane; Deafness associated genes"]
[392,"GBP5",115362,"9606.ENSP00000359488",3,0,1,0,0,1,0,"Guanine nucleotide-binding protein 5; As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP."]
[486,"BCL6",604,"9606.ENSP00000384371",3,0,1,0,0,1,0,"Zinc finger and BTB domain-containing protein 27; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6- binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53- dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH- dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation; BTB domain containing"]
[539,"FBN2",2201,"9606.ENSP00000424571",3,0,1,null,1,0,0,"Fibrillin 2; Fibrillin-2: Fibrillins are structural components of 10- 12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively; Belongs to the fibrillin family."]
[572,"ERC1",23085,"9606.ENSP00000468263",3,0,1,null,1,0,0,"ELKS/RAB6-interacting/CAST family member 1; Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport."]
[574,"UPF1",5976,"9606.ENSP00000470142",3,0,1,null,1,0,0,"UPF1 regulator of nonsense transcripts homolog (yeast); RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability."]
[599,"LARP4B",23185,"9606.ENSP00000482767",3,0,1,null,1,0,0,"La ribonucleoprotein domain family, member 4B; Stimulates mRNA translation; La ribonucleoprotein domain containing"]
[605,"CIITA",4261,"9606.ENSP00000485010",3,1,1,0,0,1,0,"Class II, major histocompatibility complex, transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro); NLR family"]
[190,"ATM",472,"9606.ENSP00000278616",3,1,1,1,0,1,0,"Ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response; Armadillo-like helical domain containing"]
[211,"FANCD2",2177,"9606.ENSP00000287647",3,0,1,1,0,1,0,"Fanconi anemia, complementation group D2; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching; Armadillo-like helical domain containing"]
[355,"ELF3",1999,"9606.ENSP00000352673",3,0,1,1,0,1,0,"E74-like factor 3 (ets domain transcription factor, epithelial-specific ); Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity)."]
[362,"PTGS1",5742,"9606.ENSP00000354612",3,0,1,1,0,1,0,"Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells; Belongs to the prostaglandin G/H synthase family."]
[198,"GJA1",2697,"9606.ENSP00000282561",2,0,1,2,0,1,0,"Gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity)."]
[370,"TGM2",7052,"9606.ENSP00000355330",2,0,1,2,0,1,0,"Protein-glutamine gamma-glutamyltransferase 2; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Transglutaminases"]
[383,"CTSS",1520,"9606.ENSP00000357981",2,0,1,2,0,1,0,"Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N; Cathepsins"]
[483,"DDX3X",1654,"9606.ENSP00000382840",2,0,1,2,0,1,0,"DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'- single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5'proximal stem-loop structure in their 5'UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5'UTRs and is independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta); proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic chromosome segregation. Is an allosteric activator of CSNK1E, it stimulates CSNK1E-mediated phosphorylation of DVL2 and is involved in the positive regulation of canonical Wnt signaling; Belongs to the DEAD box helicase family. DDX3/DED1 subfamily."]
[80,"PLAT",5327,"9606.ENSP00000220809",2,0,1,null,1,0,0,"Tissue-type plasminogen activator; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration."]
[96,"RRP9",9136,"9606.ENSP00000232888",2,0,1,null,1,0,0,"Ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast); Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA; Belongs to the WD repeat RRP9 family."]
[109,"MPHOSPH10",10199,"9606.ENSP00000244230",2,0,1,null,1,0,0,"M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; MPP10 subcomplex"]
[139,"MIB1",57534,"9606.ENSP00000261537",2,0,1,null,1,0,0,"Zinc finger ZZ type with ankyrin repeat domain protein 2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation; Ankyrin repeat domain containing"]
[180,"AKAP8",10270,"9606.ENSP00000269701",2,0,1,null,1,0,0,"A kinase (PRKA) anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity); Belongs to the AKAP95 family."]
[205,"ADAMTS1",9510,"9606.ENSP00000284984",2,0,1,null,1,0,0,"A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif"]
[151,"CD81",975,"9606.ENSP00000263645",2,0,1,1,0,1,0,"Target of the antiproliferative antibody 1; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV; CD molecules"]
[158,"MECOM",2122,"9606.ENSP00000264674",2,1,1,1,0,1,0,"Ecotropic virus integration site 1 protein homolog; Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis; Lysine methyltransferases"]
[234,"JAM3",83700,"9606.ENSP00000299106",2,0,1,1,0,1,0,"Junctional adhesion molecule 3; Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis; Belongs to the immunoglobulin superfamily."]
[235,"VPS35",55737,"9606.ENSP00000299138",2,0,1,1,0,1,0,"Vacuolar protein sorting 35 homolog (S. cerevisiae); Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for endosomal localization of WASHC2C. Mediates the association of the CSC with the WASH complex via WASHC2. Required for the endosomal localization of TBC1D5."]
[346,"GOLGA7",51125,"9606.ENSP00000350378",2,0,1,null,1,0,0,"Golgi complex-associated protein of 16 kDa; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS."]
[536,"ADAMTS12",81792,"9606.ENSP00000422554",2,0,1,1,0,1,0,"A disintegrin and metalloproteinase with thrombospondin motifs 12; Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties; ADAM metallopeptidases with thrombospondin type 1 motif"]
[369,"COL6A1",1291,"9606.ENSP00000355180",2,0,1,null,1,0,0,"Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family."]
[166,"STAP1",26228,"9606.ENSP00000265404",2,0,1,0,0,1,0,"Signal transducing adaptor family member 1; In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC; SH2 domain containing"]
[302,"IL1R2",7850,"9606.ENSP00000330959",2,0,1,0,0,1,0,"CD121 antigen-like family member B; Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors; CD molecules"]
[339,"STK39",27347,"9606.ENSP00000348278",2,0,1,0,0,1,0,"STE20/SPS1-related proline-alanine-rich protein kinase; May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation."]
[420,"POFUT1",23509,"9606.ENSP00000364902",2,0,1,null,1,0,0,"GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs); Fucosyltransferases"]
[421,"CSNK2B",1460,"9606.ENSP00000365042",2,0,1,null,1,0,0,"Casein kinase 2, beta polypeptide; Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family."]
[350,"CD163",9332,"9606.ENSP00000352071",2,1,1,0,0,1,0,"Scavenger receptor cysteine-rich type 1 protein M130; Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells; CD molecules"]
[374,"MAPKAPK2",9261,"9606.ENSP00000356070",2,0,1,0,0,1,0,"Mitogen-activated protein kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3."]
[440,"LY86",9450,"9606.ENSP00000369286",2,0,1,0,0,1,0,"Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity)."]
[447,"IL33",90865,"9606.ENSP00000370842",2,0,1,0,0,1,0,"Nuclear factor from high endothelial venules; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an \"alarmin\", that amplifies immune responses during tissue injury; Interleukins"]
[581,"NR1H3",10062,"9606.ENSP00000477707",2,0,1,0,0,1,0,"Nuclear receptor subfamily 1, group H, member 3; Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity; Nuclear hormone receptors"]
[67,"PKP2",5318,"9606.ENSP00000070846",1,0,1,null,1,0,0,"Plakophilin 2; May play a role in junctional plaques; Armadillo repeat containing"]
[163,"MGLL",11343,"9606.ENSP00000265052",1,0,1,1,0,1,0,"Lysophospholipase homolog; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth; Lipases"]
[248,"ABR",29,"9606.ENSP00000303909",1,1,1,1,0,1,0,"Active breakpoint cluster region-related protein; GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them; C2 domain containing"]
[264,"PPARD",5467,"9606.ENSP00000310928",1,0,1,1,0,1,0,"Peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand; Belongs to the nuclear hormone receptor family. NR1 subfamily."]
[323,"MCPH1",79648,"9606.ENSP00000342924",1,0,1,1,0,1,0,"Microcephalin 1; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex."]
[325,"CDH5",1003,"9606.ENSP00000344115",1,0,1,1,0,1,0,"Cadherin 5, type 2 (vascular endothelium); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction; CD molecules"]
[182,"MRPS5",64969,"9606.ENSP00000272418",1,0,1,null,1,0,0,"Mitochondrial ribosomal protein S5"]
[480,"GSTP1",2950,"9606.ENSP00000381607",1,0,1,1,0,1,0,"Glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration; Soluble glutathione S-transferases"]
[506,"CYLD",1540,"9606.ENSP00000392025",1,0,1,1,0,1,0,"Ubiquitin-specific-processing protease CYLD; Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation; Belongs to the peptidase C19 family."]
[537,"SLIT2",9353,"9606.ENSP00000422591",1,1,1,1,0,1,0,"Slit homolog 2 (Drosophila); Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth- stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post- crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration."]
[74,"HMOX1",3162,"9606.ENSP00000216117",1,0,1,0,1,1,1,"Heme oxygenase (decycling) 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis."]
[101,"IL1RL1",9173,"9606.ENSP00000233954",1,0,1,0,0,1,0,"Interleukin 1 receptor-like 1; Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function; I-set domain containing"]
[138,"RORA",6095,"9606.ENSP00000261523",1,1,1,0,0,1,0,"Nuclear receptor subfamily 1 group F member 1; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium- mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti- inflammatory role by inducing CHUK expression and inhibiting NF- kappa-B signaling."]
[142,"NDST1",3340,"9606.ENSP00000261797",1,0,1,0,0,1,0,"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response. Required for the exosomal release of SDCBP, CD63 and syndecan; Sulfotransferases, membrane bound"]
[224,"HMGB2",3148,"9606.ENSP00000296503",1,0,1,0,0,1,0,"High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity); Belongs to the HMGB family."]
[228,"RICTOR",253260,"9606.ENSP00000296782",1,0,1,0,0,1,0,"RPTOR independent companion of MTOR, complex 2; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development; Armadillo-like helical domain containing"]
[263,"RASGRP1",10125,"9606.ENSP00000310244",1,0,1,0,0,1,0,"Calcium and DAG-regulated guanine nucleotide exchange factor II; Functions as a calcium- and diacylglycerol (DAG)- regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B- lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM- dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types; Belongs to the RASGRP family."]
[331,"TOR1A",1861,"9606.ENSP00000345719",1,0,1,null,1,0,0,"Torsin family 1, member A (torsin A); Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non- neural tissues."]
[281,"TNIP1",10318,"9606.ENSP00000317891",1,0,1,0,0,1,0,"A20-binding inhibitor of NF-kappa-B activation 1; Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection."]
[301,"P2RX7",5027,"9606.ENSP00000330696",1,0,1,0,0,1,0,"Purinergic receptor P2X, ligand-gated ion channel, 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells; Purinergic receptors P2X"]
[393,"HS2ST1",9653,"9606.ENSP00000359581",1,0,1,null,1,0,0,"Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity); Sulfotransferases, membrane bound"]
[444,"PITRM1",10531,"9606.ENSP00000370377",1,0,1,null,1,0,0,"Presequence protease, mitochondrial; ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference; Belongs to the peptidase M16 family. PreP subfamily."]
[304,"PRKD1",5587,"9606.ENSP00000333568",1,0,1,0,0,1,0,"Serine/threonine-protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)- induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa- B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells. Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily."]
[365,"SGMS1",259230,"9606.ENSP00000354829",1,0,1,0,0,1,0,"Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide; Sterile alpha motif domain containing"]
[375,"CFH",3075,"9606.ENSP00000356399",1,0,1,0,0,1,0,"Complement factor H; Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway."]
[504,"TCF12",6938,"9606.ENSP00000388940",1,0,1,null,1,0,0,"Class B basic helix-loop-helix protein 20; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'); Basic helix-loop-helix proteins"]
[455,"FANCA",2175,"9606.ENSP00000373952",1,0,1,0,0,1,0,"Fanconi anemia, complementation group A; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability; Fanconi anemia complementation groups"]
[476,"NFKBID",84807,"9606.ENSP00000380109",1,0,1,0,0,1,0,"Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta; May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes (By similarity); Ankyrin repeat domain containing"]
[519,"GPX1",2876,"9606.ENSP00000407375",1,0,1,null,1,0,0,"Cellular glutathione peroxidase; Protects the hemoglobin in erythrocytes from oxidative breakdown; Belongs to the glutathione peroxidase family."]
[508,"FGFR1",2260,"9606.ENSP00000393312",1,0,1,0,0,1,0,"Basic fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation."]
[545,"HS6ST2",90161,"9606.ENSP00000429473",1,0,1,null,1,0,0,"Heparan sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate."]
[554,"DICER1",23405,"9606.ENSP00000437256",1,0,1,0,0,1,0,"Dicer 1, ribonuclease type III; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes."]
[589,"ALOX5AP",241,"9606.ENSP00000479870",1,0,1,0,0,1,0,"Arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes; Belongs to the MAPEG family."]
[594,"CSDE1",7812,"9606.ENSP00000481762",1,0,1,null,1,0,0,"Cold shock domain containing E1, RNA-binding; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain."]
[598,"PCSK6",5046,"9606.ENSP00000482760",1,0,1,null,1,0,0,"Proprotein convertase subtilisin/kexin type 6; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues; Proprotein convertase subtilisin/kexin family"]

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[]
["Supplementary Table 4. Venn diagram of essential inflammatory response proteins related to cancer hallmark phenotypes "]
[]
["Names","total","elements"]
["ANGIOGENESIS, CELL DEATH, GLYCOLISIS, INFLAMMATION",34,"PIK3CG"]
[null,null,"LYN"]
[null,null,"TLR4"]
[null,null,"APP"]
[null,null,"NFKBIA"]
[null,null,"EDNRB"]
[null,null,"TGFB1"]
[null,null,"EGFR"]
[null,null,"EDNRA"]
[null,null,"PTGFR"]
[null,null,"JAK2"]
[null,null,"CSF1"]
[null,null,"CYLD"]
[null,null,"NOTCH1"]
[null,null,"CD28"]
[null,null,"PRKCZ"]
[null,null,"TNFAIP3"]
[null,null,"STAT3"]
[null,null,"FN1"]
[null,null,"EPHA2"]
[null,null,"IGF1"]
[null,null,"CNR2"]
[null,null,"MAPK14"]
[null,null,"TNFRSF1B"]
[null,null,"RBPJ"]
[null,null,"CYSLTR1"]
[null,null,"CCL5"]
[null,null,"HGF"]
[null,null,"PTAFR"]
[null,null,"PRKCQ"]
[null,null,"FPR1"]
[null,null,"MECOM"]
[null,null,"ATM"]
[null,null,"PTGS2"]
["CELL DEATH, GLYCOLISIS, INFLAMMATION",5,"PTPN2"]
[null,null,"ABR"]
[null,null,"THBS1"]
[null,null,"BCR"]
[null,null,"SOCS3"]
["ANGIOGENESIS, GLYCOLISIS, INFLAMMATION",9,"HDAC9"]
[null,null,"NFKB1"]
[null,null,"CEBPB"]
[null,null,"PPARG"]
[null,null,"LY96"]
[null,null,"NOTCH2"]
[null,null,"HMGB1"]
[null,null,"DHX9"]
[null,null,"RPS6KA5"]
["ANGIOGENESIS, CELL DEATH, GLYCOLISIS",1,"PRKCA"]
["ANGIOGENESIS, GLYCOLISIS",1,"GRN"]

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[]
["Supplementary Table 5. Shortest paths from inflammatory response proteins to cancer hallmark phenotypes"]
[]
["PROTEINS","HALLMARKS","PATH STRING","DISTANCE","PATH LENGTH","FINAL EFFECT"]
["TGFB1","ANGIOGENESIS","TGFB1--> ANGIOGENESIS",0.864,1,1]
["ATM","CELL_DEATH","ATM--> TP53--> CELL_DEATH",1.204,2,1]
["ATM","GLYCOLYSIS","ATM--> HIF1A--> GLYCOLYSIS",1.666,2,1]
["PTGS2","INFLAMMATION","PTGS2--> INFLAMMATION",0.531,1,1]
["STAT3","ANGIOGENESIS","STAT3--> VEGFA--> ANGIOGENESIS",1.966,2,1]
["NFKBIA","CELL_DEATH","NFKBIA--| NFKB-P65/P50--| CELL_DEATH",1.422,2,1]
["CD28","GLYCOLYSIS","CD28--> GRB2--> SOS1--> KRAS--> GLYCOLYSIS",1.839,4,1]
["PRKCZ","INFLAMMATION","PRKCZ--> NFKB-P65/P50--> INFLAMMATION",1.394,2,1]
["MAPK14","ANGIOGENESIS","MAPK14--> ADAM17--> TNF--> ANGIOGENESIS",1.977,3,1]
["TNFRSF1B","CELL_DEATH","TNFRSF1B--> TRAF2--> RIPK1--> CASP8--> CELL_DEATH",1.644,4,1]
["EGFR","GLYCOLYSIS","EGFR--> SHC1--> SOS1--> KRAS--> GLYCOLYSIS",1.976,4,1]
["NFKBIA","INFLAMMATION","NFKBIA--> RELA--> IL6--> INFLAMMATION",{"v":1.71,"d":"1.710"},3,1]
["EGFR","ANGIOGENESIS","EGFR--> STAT3--> VEGFA--> ANGIOGENESIS",2.484,3,1]
["APP","CELL_DEATH","APP--> NAE1--> CELL_DEATH",1.728,2,1]
["TNFAIP3","GLYCOLYSIS","TNFAIP3--| TRAF6--| HK2--> GLYCOLYSIS",2.002,3,1]
["MAPK14","INFLAMMATION","MAPK14--> ADAM17--> TNF--> INFLAMMATION",1.915,3,1]
["JAK2","ANGIOGENESIS","JAK2--> STAT3--> VEGFA--> ANGIOGENESIS",2.584,3,1]
["MAPK14","CELL_DEATH","MAPK14--> FOXO--> CELL_DEATH",1.728,2,1]
["HGF","GLYCOLYSIS","HGF--> MET--> GRB2--> SOS1--> HRAS--> BRAF--> GLYCOLYSIS",2.032,6,1]
["TNFRSF1B","INFLAMMATION","TNFRSF1B--> TRAF2--> RIPK1--> IKK-COMPLEX--> NFKB-P65/P50--> INFLAMMATION",2.399,5,1]
["ATM","ANGIOGENESIS","ATM--> HIF1A--> VEGFA--> ANGIOGENESIS",2.914,3,1]
["PRKCZ","CELL_DEATH","PRKCZ--> STK11--> TP53--> CELL_DEATH",1.934,3,1]
["CYLD","GLYCOLYSIS","CYLD--| TRAF6--| HK2--> GLYCOLYSIS",2.092,3,1]
["TLR4","INFLAMMATION","TLR4--> TICAM1--> TBK1--> NFKB-P65/P50--> INFLAMMATION",2.437,4,1]
["NFKBIA","ANGIOGENESIS","NFKBIA--> RELA--> JUN--> TGFB1--> ANGIOGENESIS",2.963,4,1]
["TLR4","CELL_DEATH","TLR4--> TICAM1--> RIPK1--> CASP8--> CELL_DEATH",1.968,4,1]
["PRKCZ","GLYCOLYSIS","PRKCZ--> STK11--> AMPK--> GLYCOLYSIS",2.208,3,1]
["ATM","INFLAMMATION","ATM--> HIF1A--> CCL2--> INFLAMMATION",2.453,3,1]
["PRKCZ","ANGIOGENESIS","PRKCZ--| GSK3B--| JUN--> TGFB1--> ANGIOGENESIS",3.134,4,1]
["JAK2","CELL_DEATH","JAK2--> STAT1--| NFKB-P65/P50--| CELL_DEATH",2.261,3,1]
["EPHA2","GLYCOLYSIS","EPHA2--> SHC1--> GRB2--> SOS1--> KRAS--> GLYCOLYSIS",2.248,5,1]
["MECOM","INFLAMMATION","MECOM--| RUNX1--| IKK-COMPLEX--> NFKB-P65/P50--> INFLAMMATION",2.572,4,1]
["TLR4","ANGIOGENESIS","TLR4--> MYD88--> IRAK1--> STAT3--> VEGFA--> ANGIOGENESIS",3.352,5,1]
["TGFB1","CELL_DEATH","TGFB1--> TGFBR1--> TRAF6--| HK2--| CELL_DEATH",2.348,4,1]
["JAK2","GLYCOLYSIS","JAK2--> PTPN11--> KRAS--> GLYCOLYSIS",2.272,3,1]
["PIK3CG","INFLAMMATION","PIK3CG--> AKT--> IKK-COMPLEX--> NFKB-P65/P50--> INFLAMMATION",2.631,4,1]
["PTAFR","ANGIOGENESIS","PTAFR--> GNAI1--> SRC--> TGFA--> ANGIOGENESIS",3.456,4,1]
["MECOM","CELL_DEATH","MECOM--| SMAD3--| FOXA1--> CELL_DEATH",2.364,3,1]
["PIK3CG","GLYCOLYSIS","PIK3CG--> AKT--> HK2--> GLYCOLYSIS",2.342,3,1]
["EGFR","INFLAMMATION","EGFR--> PTPN1--| NFKBIA--| NFKB-P65/P50--> INFLAMMATION",{"v":2.64,"d":"2.640"},4,1]
["FPR1","ANGIOGENESIS","FPR1--> GNAI1--> SRC--> TGFA--> ANGIOGENESIS",3.456,4,1]
["LYN","CELL_DEATH","LYN--> PTPN6--> CASP8--> CELL_DEATH",2.375,3,1]
["MAPK14","GLYCOLYSIS","MAPK14--> DUSP1--| MAPK3--| BRAF--> GLYCOLYSIS",2.419,4,1]
["JAK2","INFLAMMATION","JAK2--> PTPN11--| STAT1--| NFKB-P65/P50--> INFLAMMATION",2.663,4,1]
["EDNRA","ANGIOGENESIS","EDNRA--> GNAI1--> SRC--> TGFA--> ANGIOGENESIS",3.456,4,1]
["EGFR","CELL_DEATH","EGFR--> STAT1--| NFKB-P65/P50--| CELL_DEATH",2.446,3,1]
["RBPJ","GLYCOLYSIS","RBPJ--[] RBPJ/NOTCH--> HIF1A--> GLYCOLYSIS",{"v":2.44,"d":"2.440"},3,1]
["LYN","INFLAMMATION","LYN--> PTPN6--| KIT--> STAT1--| NFKB-P65/P50--> INFLAMMATION",2.976,5,1]
["EDNRB","ANGIOGENESIS","EDNRB--> GNAI1--> SRC--> TGFA--> ANGIOGENESIS",3.456,4,1]
["PIK3CG","CELL_DEATH","PIK3CG--> AKT--| YAP1--| CELL_DEATH",2.592,3,1]
["NOTCH1","GLYCOLYSIS","NOTCH1--[] RBPJ/NOTCH--> HIF1A--> GLYCOLYSIS",{"v":2.53,"d":"2.530"},3,1]
["CYLD","INFLAMMATION","CYLD--| BCL3--> HDAC1--| NFKB-P65/P50--> INFLAMMATION",2.983,4,1]
["CYSLTR1","ANGIOGENESIS","CYSLTR1--> GNAI1--> SRC--> TGFA--> ANGIOGENESIS",3.456,4,1]
["TNFAIP3","CELL_DEATH","TNFAIP3--| RIPK1--> IKK-COMPLEX--> NFKB-P65/P50--| CELL_DEATH",2.729,4,1]
["CYSLTR1","GLYCOLYSIS","CYSLTR1--> GNAQ--> HRAS--> BRAF--> GLYCOLYSIS",2.583,4,1]
["PRKCQ","INFLAMMATION","PRKCQ--> CARD11--> BCL10--> IKBKG--> NFKB-P65/P50--> INFLAMMATION",3.011,5,1]
["CNR2","ANGIOGENESIS","CNR2--> GNAI1--> SRC--> TGFA--> ANGIOGENESIS",3.456,4,1]
["CD28","CELL_DEATH","CD28--> GRB2--> ABL1--> TP73--> CELL_DEATH",2.958,4,1]
["EDNRA","GLYCOLYSIS","EDNRA--> GNAQ--> HRAS--> BRAF--> GLYCOLYSIS",2.605,4,1]
["STAT3","INFLAMMATION","STAT3--> SOCS3--| JAK2--> STAT1--| NFKB-P65/P50--> INFLAMMATION",{"v":3.02,"d":"3.020"},5,1]
["EPHA2","ANGIOGENESIS","EPHA2--> SHC1--> GRB2--> SOS1--> HRAS--> JUN--> TGFB1--> ANGIOGENESIS",3.668,7,1]
["RBPJ","CELL_DEATH","RBPJ--> CDKN1A--| CDK2--| FOXO--> CELL_DEATH",{"v":3.02,"d":"3.020"},4,1]
["LYN","GLYCOLYSIS","LYN--> PLCG1--> SOS1--> HRAS--> BRAF--> GLYCOLYSIS",2.642,5,1]
["TGFB1","INFLAMMATION","TGFB1--> PPP2R2A--| PPP2CA--| NFKB-P65/P50--> INFLAMMATION",3.122,4,1]
["RBPJ","ANGIOGENESIS","RBPJ--[] RBPJ/NOTCH--> HIF1A--> VEGFA--> ANGIOGENESIS",3.688,4,1]
["IGF1","CELL_DEATH","IGF1--> IGF1R--> PIK3R3--> TP53--> CELL_DEATH",3.144,4,1]
["PTAFR","GLYCOLYSIS","PTAFR--> GNAQ--> HRAS--> BRAF--> GLYCOLYSIS",2.667,4,1]
["RBPJ","INFLAMMATION","RBPJ--> HES1--| NR3C1--> IRAK3--| INFLAMMATION",3.193,4,1]
["CCL5","ANGIOGENESIS","CCL5--> CCR3--> ERK1/2--> AP1--> CXCL8--> ANGIOGENESIS",3.719,5,1]
["STAT3","CELL_DEATH","STAT3--> SOCS3--| JAK2--> STAT5A--> PIM1--| CELL_DEATH",{"v":3.15,"d":"3.150"},5,1]
["EDNRB","GLYCOLYSIS","EDNRB--> GNAQ--> HRAS--> BRAF--> GLYCOLYSIS",2.667,4,1]
["TNFAIP3","INFLAMMATION","TNFAIP3--| TRAF6--> MAP3K14--> CHUK--| NFKB-P65/P50--> INFLAMMATION",3.232,5,1]
["PIK3CG","ANGIOGENESIS","PIK3CG--> AKT--| GSK3B--| JUN--> TGFB1--> ANGIOGENESIS",3.769,5,1]
["HGF","CELL_DEATH","HGF--> MET--> GRB2--> ABL1--> TP73--> CELL_DEATH",3.238,5,1]
["PTGFR","GLYCOLYSIS","PTGFR--> GNAQ--> HRAS--> BRAF--> GLYCOLYSIS",2.667,4,1]
["NOTCH1","INFLAMMATION","NOTCH1--[] RBPJ/NOTCH--> HIF1A--> CCL2--> INFLAMMATION",3.317,4,1]
["NOTCH1","ANGIOGENESIS","NOTCH1--[] RBPJ/NOTCH--> HIF1A--> VEGFA--> ANGIOGENESIS",3.778,4,1]
["CYLD","CELL_DEATH","CYLD--| BCL3--> NFKB1--[] NFKB-P65/P50--| CELL_DEATH",3.317,4,1]
["MECOM","GLYCOLYSIS","MECOM--| SMAD3--| MYC--> HK2--> GLYCOLYSIS",{"v":2.74,"d":"2.740"},4,1]
["IGF1","INFLAMMATION","IGF1--> IGF1R--> PDPK1--> PRKCZ--> NFKB-P65/P50--> INFLAMMATION",3.328,5,1]
["CD28","ANGIOGENESIS","CD28--> GRB2--> SOS1--> HRAS--> JUN--[] AP1--> CXCL8--> ANGIOGENESIS",3.852,7,1]
["EPHA2","CELL_DEATH","EPHA2--> SHC1--> GRB2--> ABL1--> TP73--> CELL_DEATH",3.367,5,1]
["TGFB1","GLYCOLYSIS","TGFB1--> PI3K--> AKT--> HK2--> GLYCOLYSIS",2.887,4,1]
["CD28","INFLAMMATION","CD28--> GRB2--> CBL--| EGFR--> STAT1--| NFKB-P65/P50--> INFLAMMATION",{"v":3.45,"d":"3.450"},6,1]
["TNFRSF1B","ANGIOGENESIS","TNFRSF1B--> TRAF2--> MAP3K1--> STAT3--> VEGFA--> ANGIOGENESIS",3.869,5,1]
["PRKCQ","CELL_DEATH","PRKCQ--| NOS3--> NITRIC OXIDE--> NFKB-P65/P50--| CELL_DEATH",3.372,4,1]
["NFKBIA","GLYCOLYSIS","NFKBIA--> RELA--> MET--> GRB2--> SOS1--> KRAS--> GLYCOLYSIS",2.979,6,1]
["CCL5","INFLAMMATION","CCL5--> CCR3--> ERK1/2--> AP1--> CCL2--> INFLAMMATION",3.488,5,1]
["CYLD","ANGIOGENESIS","CYLD--| TRAF2--> RIPK1--> DAB2IP--| STAT3--> VEGFA--> ANGIOGENESIS",4.014,6,1]
["PTGS2","CELL_DEATH","PTGS2--> MYOD1--> SWI/SNF COMPLEX--> TP53--> CELL_DEATH",3.456,4,1]
["STAT3","GLYCOLYSIS","STAT3--> HGF--> MET--> GRB2--> SOS1--> KRAS--> GLYCOLYSIS",2.983,6,1]
["PTAFR","INFLAMMATION","PTAFR--> GNAI1--> SRC--> IKK-COMPLEX--> NFKB-P65/P50--> INFLAMMATION",3.634,5,1]
["TNFAIP3","ANGIOGENESIS","TNFAIP3--| RIPK1--> DAB2IP--| STAT3--> VEGFA--> ANGIOGENESIS",4.059,5,1]
["FN1","CELL_DEATH","FN1--> SDC4--> RAC1--> MAPK8--> TP53--> CELL_DEATH",3.589,5,1]
["PRKCQ","GLYCOLYSIS","PRKCQ--| IRS1--> GRB2--> CBL--| FLT3--> GLYCOLYSIS",3.133,5,1]
["FPR1","INFLAMMATION","FPR1--> GNAI1--> SRC--> IKK-COMPLEX--> NFKB-P65/P50--> INFLAMMATION",3.634,5,1]
["PTGS2","ANGIOGENESIS","PTGS2--> IL4--> IL4R--> JAK1--> STAT3--> VEGFA--> ANGIOGENESIS",4.068,6,1]
["PTAFR","CELL_DEATH","PTAFR--> GNAI1--> RAC1--> MAPK8--> TP53--> CELL_DEATH",3.589,5,1]
["IGF1","GLYCOLYSIS","IGF1--| GSK3B/AXIN/APC--> CSNK1D--| HIF1A--> GLYCOLYSIS",3.255,4,1]
["EDNRA","INFLAMMATION","EDNRA--> GNAI1--> SRC--> IKK-COMPLEX--> NFKB-P65/P50--> INFLAMMATION",3.634,5,1]
["CSF1","ANGIOGENESIS","CSF1--> CSF2RA--> JAK2--> STAT3--> VEGFA--> ANGIOGENESIS",4.111,5,1]
["FPR1","CELL_DEATH","FPR1--> GNAI1--> RAC1--> MAPK8--> TP53--> CELL_DEATH",3.589,5,1]
["TLR4","GLYCOLYSIS","TLR4--> TICAM1--> TBK1--> AKT--> HK2--> GLYCOLYSIS",3.422,5,1]
["EDNRB","INFLAMMATION","EDNRB--> GNAI1--> SRC--> IKK-COMPLEX--> NFKB-P65/P50--> INFLAMMATION",3.634,5,1]
["HGF","ANGIOGENESIS","HGF--> MET--> GRB2--> SOS1--> HRAS--> JUN--[] AP1--> CXCL8--> ANGIOGENESIS",4.132,8,1]
["EDNRA","CELL_DEATH","EDNRA--> GNAI1--> RAC1--> MAPK8--> TP53--> CELL_DEATH",3.589,5,1]
["FPR1","GLYCOLYSIS","FPR1--> GNAI1--> SRC--> KRAS--> GLYCOLYSIS",3.456,4,1]
["CYSLTR1","INFLAMMATION","CYSLTR1--> GNAI1--> SRC--> IKK-COMPLEX--> NFKB-P65/P50--> INFLAMMATION",3.634,5,1]
["LYN","ANGIOGENESIS","LYN--> PTPN6--> JAK3--> STAT3--> VEGFA--> ANGIOGENESIS",{"v":4.14,"d":"4.140"},5,1]
["EDNRB","CELL_DEATH","EDNRB--> GNAI1--> RAC1--> MAPK8--> TP53--> CELL_DEATH",3.589,5,1]
["CNR2","GLYCOLYSIS","CNR2--> GNAI1--> SRC--> KRAS--> GLYCOLYSIS",3.456,4,1]
["CNR2","INFLAMMATION","CNR2--> GNAI1--> SRC--> IKK-COMPLEX--> NFKB-P65/P50--> INFLAMMATION",3.634,5,1]
["PTGFR","ANGIOGENESIS","PTGFR--> GNAQ--> HRAS--> JUN--> TGFB1--> ANGIOGENESIS",4.174,5,1]
["CYSLTR1","CELL_DEATH","CYSLTR1--> GNAI1--> RAC1--> MAPK8--> TP53--> CELL_DEATH",3.589,5,1]
["TNFRSF1B","GLYCOLYSIS","TNFRSF1B--> TRAF2--> RIPK1--> DAB2IP--| AKT--| BRAF--> GLYCOLYSIS",3.624,6,1]
["HGF","INFLAMMATION","HGF--> MET--> GRB2--> CBL--| EGFR--> STAT1--| NFKB-P65/P50--> INFLAMMATION",{"v":3.73,"d":"3.730"},7,1]
["FN1","ANGIOGENESIS","FN1--> SDC4--> DVL1--> JUN--> TGFB1--> ANGIOGENESIS",{"v":4.32,"d":"4.320"},5,1]
["CNR2","CELL_DEATH","CNR2--> GNAI1--> RAC1--> MAPK8--> TP53--> CELL_DEATH",3.589,5,1]
["CCL5","GLYCOLYSIS","CCL5--> CCR3--> ERK1/2--> RPS6KA3--> PFKFB2--> GLYCOLYSIS",3.634,5,1]
["EPHA2","INFLAMMATION","EPHA2--> SHC1--> GRB2--> CBL--| EGFR--> STAT1--| NFKB-P65/P50--> INFLAMMATION",3.859,7,1]
["PRKCQ","ANGIOGENESIS","PRKCQ--| IRS1--> GRB2--> CBL--| EGFR--> STAT3--> VEGFA--> ANGIOGENESIS",4.328,7,1]
["CCL5","CELL_DEATH","CCL5--> CCR3--> ERK1/2--> EP300--> TP53--> CELL_DEATH",3.598,5,1]
["CSF1","GLYCOLYSIS","CSF1--> CSF2RA--> JAK2--> PTPN11--> KRAS--> GLYCOLYSIS",3.799,5,1]
["FN1","INFLAMMATION","FN1--> SDC4--> RAC1--> MAPK8--> IRF3--> IL6--> INFLAMMATION",4.167,6,1]
["MECOM","ANGIOGENESIS","MECOM--| SMAD3--[] SMAD3/PIAS3--| STAT3--> VEGFA--> ANGIOGENESIS",{"v":4.33,"d":"4.330"},5,1]
["NOTCH1","CELL_DEATH","NOTCH1--> RBPJ--> CDKN1A--| CDK2--| FOXO--> CELL_DEATH",3.667,5,1]
["PTGS2","GLYCOLYSIS","PTGS2--> IL4--> IL4R--> JAK1--> PTPN11--> KRAS--> GLYCOLYSIS",4.107,6,1]
["CSF1","INFLAMMATION","CSF1--> CSF2RA--> JAK2--> PTPN11--| STAT1--| NFKB-P65/P50--> INFLAMMATION",{"v":4.19,"d":"4.190"},6,1]
["IGF1","ANGIOGENESIS","IGF1--| GSK3B/AXIN/APC--> CSNK1D--| HIF1A--> VEGFA--> ANGIOGENESIS",4.503,5,1]
["CSF1","CELL_DEATH","CSF1--> CSF2RA--> JAK2--> STAT1--| NFKB-P65/P50--| CELL_DEATH",3.788,5,1]
["FN1","GLYCOLYSIS","FN1--> SDC4--> RAC1--> MAPK8--> MYC--> HK2--> GLYCOLYSIS",4.398,6,1]
["PTGFR","INFLAMMATION","PTGFR--> GNAQ--> HRAS--> JUN--[] AP1--> CCL2--> INFLAMMATION",4.536,6,1]
["APP","ANGIOGENESIS","APP--> NAE1--[] NAE--> CUL1--[] SCF-BETATRCP--> NFKB-P65/P50--> JUN--> TGFB1--> ANGIOGENESIS",6.744,8,1]
["PTGFR","CELL_DEATH","PTGFR--> GNAQ--> RHOA--> MAPK8--> TP53--> CELL_DEATH",4.041,5,1]
["APP","GLYCOLYSIS","APP--> NAE1--[] NAE--> CUL1--[] SCF-BETATRCP--> MYC--> HK2--> GLYCOLYSIS",5.798,7,1]
["APP","INFLAMMATION","APP--> NAE1--[] NAE--> CUL1--[] SCF-BETATRCP--> NFKB-P65/P50--> INFLAMMATION",4.766,6,1]