## Causal Mediation Analysis

Outcome variable: NAFLD Exposure variable: CUNBAE Control value = 18.9261057409679 ; Treat value = 29.7185015413855 Mediator variable: TYGBMI Generalized linear model for outcome with link function = probit Adjusting variables: Nonparametric Bootstrap (resamples=1000) Confidence Intervals with the Percentile Method

| Estimate | 95% CI lower | 95% CI upper | P-value
Total effect | 0.095259 | 0.087247 | 0.103564 | <0.0001
Mediation effect (control) | 0.084892 | 0.080013 | 0.089742 | <0.0001
Mediation effect (treated) | 0.088595 | 0.084169 | 0.092888 | <0.0001
Direct effect (control) | 0.006664 | 0.000624 | 0.012755 | 0.0300
Direct effect (treated) | 0.010367 | 0.000961 | 0.019835 | 0.0300
Propotion mediated (control) | 0.891173 | 0.805038 | 0.988566 | <0.0001
Propotion mediated (treated) | 0.930047 | 0.874698 | 0.992575 | <0.0001
Mediation effect (average) | 0.086743 | 0.082252 | 0.090857 | <0.0001
Direct effect (average) | 0.008515 | 0.000793 | 0.016290 | 0.0300
Propotion mediated (average) | 0.910610 | 0.839927 | 0.990571 | <0.0001

Correlation of residuals from mediator model with residuals from outcome model: 0.013126 Sample size used: 16172 Reference: Imai, K., Keele, L., and Tingley, D. (2010b). A general approach to causal mediation analysis. Psychological Methods, 15(4), 309–334. https://cran.r-project.org/web/packages/mediation/vignettes/mediation-old.pdf Created by EmpowerStats (www.empowerstats.com) and R on 2025-09-15