## Causal Mediation Analysis

Outcome variable: NAFLD Exposure variable: CUNBAE Control value = 18.9261057409679 ; Treat value = 29.7185015413855 Mediator variable: TYG Log Generalized linear model for outcome with link function = probit Adjusting variables: Nonparametric Bootstrap (resamples=1000) Confidence Intervals with the Percentile Method

| Estimate | 95% CI lower | 95% CI upper | P-value
Total effect | 0.090308 | 0.082438 | 0.098830 | <0.0001
Mediation effect (control) | 0.018610 | 0.016294 | 0.021057 | <0.0001
Mediation effect (treated) | 0.026064 | 0.023086 | 0.029161 | <0.0001
Direct effect (control) | 0.064244 | 0.056631 | 0.071537 | <0.0001
Direct effect (treated) | 0.071697 | 0.063582 | 0.079819 | <0.0001
Propotion mediated (control) | 0.206076 | 0.178663 | 0.237848 | <0.0001
Propotion mediated (treated) | 0.288610 | 0.258033 | 0.322226 | <0.0001
Mediation effect (average) | 0.022337 | 0.019642 | 0.025035 | <0.0001
Direct effect (average) | 0.067971 | 0.060179 | 0.075653 | <0.0001
Propotion mediated (average) | 0.247343 | 0.218560 | 0.280870 | <0.0001

Correlation of residuals from mediator model with residuals from outcome model: 0.009563 Sample size used: 16172 Reference: Imai, K., Keele, L., and Tingley, D. (2010b). A general approach to causal mediation analysis. Psychological Methods, 15(4), 309–334. https://cran.r-project.org/web/packages/mediation/vignettes/mediation-old.pdf Created by EmpowerStats (www.empowerstats.com) and R on 2025-09-15