# Herpes simplex virus 1 infection - Reference pathway

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- nt06114 PI3K signaling (viruses)
  - N00583 HSV VP11/12 to PI3K signaling pathway
  - N00584 HSV US3 to MTOR signaling pathway
- nt06121 TLR signaling (viruses and bacteria)
  - N00561 HSV ICP0 to TLR2/4-NFKB signaling pathway
  - N00562 HSV US3 to TLR2/4-NFKB signaling pathway
  - N00564 HSV US3 to TLR3-NFKB signaling pathway
- nt06133 RLR signaling (viruses)
  - N00565 HSV US11 to RIG-I-like receptor signaling pathway
  - N00566 HSV UL36USP to RIG-I-like receptor signaling pathway
  - N00567 HSV ICP34.5 to TBK1 signaling pathway
  - N00568 HSV US3 to IRF3 signaling pathway
- nt06134 CGAS-STING signaling (viruses and bacteria)
  - N00569 HSV UL41 to cGAS-STING signaling pathway
  - N00570 HSV ICP0 to cGAS-STING signaling pathway
- nt06137 OAS/RNase L pathway (viruses)
  - N00574 HSV US11 to oligoadenylate synthetase (OAS)/RNase L pathway
- nt06138 PKR-eIF2alpha signaling (viruses)
  - N00573 HSV US11 to PKR-eIF2alpha signaling pathway
  - N00572 HSV ICP34.5 to PKR-eIF2alpha signaling pathway
- nt06136 Complement activation (viruses)
  - N00589 HSV gC to alternative pathway of complement activation
- nt06122 IFN signaling (viruses)
  - N00576 HSV UL41/UL13 to IFN signaling pathway
  - N00577 HSV UL41 to IFN signaling pathway
  - N00578 HSV UL41 to IFN signaling pathway
  - N00575 HSV ICP27 to IFN signaling pathway
- nt06123 TNF signaling (viruses and bacteria)
  - N00560 HSV gD to HVEM-NFKB signaling pathway
- nt06129 MHC presentation (viruses)
  - N00581 HSV ICP47 to antigen processing and presentation by MHC class I molecules
  - N00591 HSV gB to antigen processing and presentation by MHC class II molecules
- nt06131 Apoptosis (viruses and bacteria)
  - N00579 HSV ICP6 to extrinsic apoptotic pathway
  - N00580 HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways
  - N00585 HSV US3 to intrinsic apoptotic pathway
- nt06140 Transcription (viruses)
  - N00592 HSV ICP0 to p53-mediated transcription
  - N00588 HSV VP16 to Oct-1-mediated transcription
- nt06168 Herpes simplex virus 1 (HSV-1)
  - N00587 HSV ICP27 to Nuclear export of mRNA