# Cushing syndrome - Reference pathway

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- nt06310 CRH-ACTH-cortisol signaling
  - N00325 Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
  - N00326 Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
  - N00327 Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
  - N00321 Mutation-activated GNAS to ACTH-cortisol signaling pathway
  - N00323 Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
  - N00320 Mutation-activated PRKACA to ACTH-cortisol signaling pathway
  - N00322 Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
  - N00319 Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
- nt06360 Cushing syndrome
  - N00315 Mutation-inactivated AIP to AhR-mediated transcription
  - N00316 Mutation-inactivated CDKN1B to p27-cell cycle G1/S