# Glioma - Reference pathway

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- nt06210 ERK signaling
  - N00513 Mutation-activated EGFR to RAS-ERK signaling pathway
  - N00006 Amplified EGFR to RAS-ERK signaling pathway
  - N00041 EGFR-overexpression to RAS-ERK signaling pathway
  - N00016 PDGF-overexpression to RAS-ERK signaling pathway
  - N00018 Amplified PDGFR to RAS-ERK signaling pathway
- nt06214 PI3K signaling
  - N00514 Mutation-activated EGFR to PI3K signaling pathway
  - N00035 Amplified EGFR to PI3K signaling pathway
  - N00042 EGFR-overexpression to PI3K signaling pathway
  - N00040 Amplified PDGFR to PI3K signaling pathway
  - N00051 Deleted PTEN to PI3K signaling pathway
  - N00052 Mutation-inactivated PTEN to PI3K signaling pathway
- nt06220 Calcium signaling
  - N00027 Amplified EGFR to PLCG-CAMK signaling pathway
  - N00029 Amplified PDGFR to PLCG-CAMK signaling pathway
- nt06230 Cell cycle
  - N00067 Deleted p14(ARF) to p21-cell cycle G1/S
  - N00068 Amplified MDM2 to p21-cell cycle G1/S
  - N00071 Deleted p16(INK4a) to p16-cell cycle G1/S
  - N00072 Amplified CDK4 to cell cycle G1/S
  - N00074 Loss of RB1 to cell cycle G1/S
- nt06240 Transcription
  - N00115 Mutation-inactivated TP53 to transcription