# Acute myeloid leukemia - Reference pathway

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- nt06210 ERK signaling
  - N00003 Mutation-activated KIT to RAS-ERK signaling pathway
  - N00004 Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
  - N00012 Mutation-activated KRAS/NRAS to ERK signaling pathway
- nt06214 PI3K signaling
  - N00046 Mutation-activated KIT to PI3K signaling pathway
  - N00031 Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
  - N00032 Mutation-activated KRAS/NRAS to PI3K signaling pathway
- nt06219 JAK-STAT signaling
  - N00054 Duplication or mutation-activated FLT3 to Jak-STAT signaling pathway
- nt06240 Transcription
  - N00116 Mutation-inactivated RUNX1 to transcription
  - N00111 AML1-ETO fusion to CEBPA-mediated transcription
  - N00112 AML1-ETO fusion to PU.1-mediated transcription
  - N00108 AML1-ETO fusion to transcriptional activtion
  - N00109 PML-RARA fusion to transcriptional activtion
  - N00113 PML-RARA fusion to transcriptional repression
  - N00110 PLZF-RARA fusion to transcriptional activtion
  - N00114 PLZF-RARA fusion to transcriptional repression