# Melanoma - Reference pathway

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- nt06210 ERK signaling
  - N00012 Mutation-activated KRAS/NRAS to ERK signaling pathway
  - N00013 Mutation-activated BRAF to ERK signaling pathway
- nt06214 PI3K signaling
  - N00051 Deleted PTEN to PI3K signaling pathway
  - N00052 Mutation-inactivated PTEN to PI3K signaling pathway
  - N00032 Mutation-activated KRAS/NRAS to PI3K signaling pathway
- nt06230 Cell cycle
  - N00067 Deleted p14(ARF) to p21-cell cycle G1/S
  - N00076 Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
  - N00070 Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
  - N00071 Deleted p16(INK4a) to p16-cell cycle G1/S
  - N00073 Mutation-activated CDK4 to cell cycle G1/S
- nt06240 Transcription
  - N00115 Mutation-inactivated TP53 to transcription