# Pathways of neurodegeneration - multiple diseases - Reference pathway

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- nt06410 Calcium signaling
  - N00953 mGluR1-TRPC3 signaling pathway
  - N00984 mGluR5-Ca2+ -apoptotic pathway
  - N01000 mAChR-Ca2+ -apoptotic pathway
  - N00967 VGCC-Ca2+ -apoptotic pathway
  - N00970 Transport of calcium
- nt06420 Ubiquitin-proteasome system
  - N01019 Parkin-mediated ubiquitination
  - N01021 Parkin-mediated ubiquitination
  - N01023 Parkin-mediated ubiquitination
  - N01029 26S proteasome-mediated protein degradation
  - N01027 UCHL1-mediated hydrolysis
- nt06412 Unfolded protein response (UPR) signaling
  - N01009 PERK-ATF4 signaling pathway
  - N01011 IRE1a-XBP1 signaling pathway
  - N01013 IRE1a-JNK signaling pathway
  - N01015 ATF6-mediated transcription
- nt06413 Autophagy
  - N01142 C9orf72-mediated autophagy initiation
  - N00155 Autophagy-vesicle nucleation
- nt06421 Mitophagy
  - N01052 PINK1-Parkin-mediated MFN2 degradation
  - N01137 PINK-Parkin-mediated autophagosome formation
  - N01140 TBK1-mediated autophagosome formation
- nt06414 Apoptosis
  - N00146 Crosstalk between extrinsic and intrinsic apoptotic pathways
  - N00098 Intrinsic apoptotic pathway
- nt06417 AGE-RAGE signaling
  - N00994 AGE-RAGE signaling pathway
- nt06418 Oxidative phosphorylation
  - N00995 Electron transfer in Complex I
  - N00988 Electron transfer in Complex II
  - N00990 Electron transfer in Complex III
  - N00998 Electron transfer in Complex IV
- nt06419 Microtubule-based transport
  - N00976 Retrograde axonal transport
  - N00978 Anterograde axonal transport