# Colorectal cancer - Reference pathway

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- nt06210 ERK signaling
  - N00276 EGF-overexpression to RAS-ERK signaling pathway
  - N00230 TGFA-overexpression to RAS-ERK signaling pathway
  - N00278 EREG-overexpression to RAS-ERK signaling pathway
  - N00280 AREG-overexpression to RAS-ERK signaling pathway
  - N00041 EGFR-overexpression to RAS-ERK signaling pathway
  - N00012 Mutation-activated KRAS/NRAS to ERK signaling pathway
- nt06214 PI3K signaling
  - N00281 EGF-overexpression to PI3K signaling pathway
  - N00232 TGFA-overexpression to PI3K signaling pathway
  - N00283 EREG-overexpression to PI3K signaling pathway
  - N00285 AREG-overexpression to PI3K signaling pathway
  - N00042 EGFR-overexpression to PI3K signaling pathway
  - N00032 Mutation-activated KRAS/NRAS to PI3K signaling pathway
- nt06213 Other RAS signaling
  - N00104 Mutation-activated KRAS to RalGDS signaling pathway
- nt06215 WNT signaling
  - N00057 Mutation-inactivated APC to Wnt signaling pathway
  - N00058 Mutation-activated CTNNB1 to Wnt signaling pathway
- nt06218 TGFB signaling
  - N00064 Mutation-inactivated TGFBR2 to TGF-beta signaling pathway
  - N00065 Mutation-inactivated SMAD2 to TGF-beta signaling pathway
- nt06231 Apoptosis
  - N00099 Mutation-inactivated BAX to apoptotic pathway
  - N00102 Loss of DCC to DCC-apoptotic pathway
- nt06240 Transcription
  - N00115 Mutation-inactivated TP53 to transcription