# Prion disease - Reference pathway

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- nt06410 Calcium signaling
  - N01199 Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway
  - N01201 Scrapie conformation PrPSc to VGCC-Ca2+ -apoptotic pathway
  - N01200 Scrapie conformation PrPSc to transport of calcium
- nt06420 Ubiquitin-proteasome system
  - N01197 Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
- nt06412 Unfolded protein response (UPR) signaling
  - N01198 Scrapie conformation PrPSc to PERK-ATF4 signaling pathway
- nt06415 PI3K signaling
  - N01205 Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
- nt06419 Microtubule-based transport
  - N01202 Oligomeric conformation PrPc to anterograde axonal transport
- nt06465 Prion disease
  - N01203 Scrapie conformation PrPSc to Notch singling pathway