# Hepatocellular carcinoma - Reference pathway

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- nt06210 ERK signaling
  - N00230 TGFA-overexpression to RAS-ERK signaling pathway
  - N00235 IGF2-overexpression to RAS-ERK signaling pathway
  - N00237 IGF1R-overexpression to RAS-ERK signaling pathway
  - N00246 HGF-overexpression to RAS-ERK signaling pathway
  - N00005 Mutation-activated MET to RAS-ERK signaling pathway
  - N00248 MET-overexpression to RAS-ERK signaling pathway
- nt06214 PI3K signaling
  - N00232 TGFA-overexpression to PI3K signaling pathway
  - N00236 IGF2-overexpression to PI3K signaling pathway
  - N00238 IGF1R-overexpression to PI3K signaling pathway
  - N00247 HGF-overexpression to PI3K signaling pathway
  - N00044 Mutation-activated MET to PI3K signaling pathway
  - N00249 MET-overexpression to PI3K signaling pathway
  - N00049 Mutation-activated PI3K to PI3K signaling pathway
  - N00052 Mutation-inactivated PTEN to PI3K signaling pathway
- nt06215 WNT signaling
  - N00059 FZD7-overexpression to Wnt signaling pathway
  - N00242 Mutation-inactivated AXIN to Wnt signaling pathway
  - N00058 Mutation-activated CTNNB1 to Wnt signaling pathway
- nt06218 TGFB signaling
  - N00241 TGFBR2-reduced expression to TGF-beta signaling pathway
- nt06220 Calcium signaling
  - N00228 TGFA-overexpression to PLCG-PKC signaling pathway
- nt06226 KEAP1-NRF2 signaling
  - N00244 Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
  - N00245 Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
- nt06230 Cell cycle
  - N00071 Deleted p16(INK4a) to p16-cell cycle G1/S
  - N00074 Loss of RB1 to cell cycle G1/S
- nt06232 Telomerase activity
  - N00240 TERT-overexpression to telomerase activity
- nt06240 Transcription
  - N00115 Mutation-inactivated TP53 to transcription