# Non-small cell lung cancer - Reference pathway

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- nt06210 ERK signaling
  - N00014 Mutation-activated EGFR to RAS-ERK signaling pathway
  - N00041 EGFR-overexpression to RAS-ERK signaling pathway
  - N00022 ERBB2-overexpression to RAS-ERK signaling pathway
  - N01062 Mutation-activated MET to RAS-ERK signaling pathway
  - N00008 RET fusion kinase to RAS-ERK signaling pathway
  - N00007 EML4-ALK fusion kinase to RAS-ERK signaling pathway
  - N00012 Mutation-activated KRAS/NRAS to ERK signaling pathway
- nt06214 PI3K signaling
  - N00036 Mutation-activated EGFR to PI3K signaling pathway
  - N01063 Mutation-activated MET to PI3K signaling pathway
  - N00047 EML4-ALK fusion kinase to PI3K signaling pathway
  - N00032 Mutation-activated KRAS/NRAS to PI3K signaling pathway
- nt06213 Other RAS signaling
  - N00097 Loss of RASSF1 to RAS-RASSF1 signaling pathway
- nt06219 JAK-STAT signaling
  - N00105 EML4-ALK fusion kinase to Jak-STAT signaling pathway
- nt06220 Calcium signaling
  - N00024 Mutation-activated EGFR to PLCG-ERK signaling pathway
  - N00025 EML4-ALK fusion kinase to PLCG-ERK signaling pathway
- nt06230 Cell cycle
  - N00070 Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
- nt06240 Transcription
  - N00115 Mutation-inactivated TP53 to transcription