{"text_format":"3","workbook":"xlsx","n_sheets":30,"sheets":["Nf1fl","delE9","delE12","delE17","delE1819","delE20","delE21","delE25","delE28","delE36","delE41","delE46","delE47","delE52","Exons - Overview","Consurf","Nf1fl (alt order)","E9","E12","E17","E18E19","E20","E21","E25","E28","E36","E41","E46","E47","E52"],"not_rendered":{"images":47,"defined_names":38},"read":"whole","date_system":"1900"}

{"sheet":"Nf1fl","index":0,"n_rows":2820,"n_cols":52,"rows_kept":2250,"cut":true,"merged":[[0,0,0,41]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["NF1 full length"]
["No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding"]
[1,"M","L","L",9,0,169,0,90,4,0,0,9,"b","e","b","e",1,1,96,8,8,8,9,11,13,14,16,24,28,1,"M",0.32,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":9},"NO        : Position"]
[2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",9,7,86,6,6,7,10,13,16,19,21,26,28,2,"A",0.21,"-",0.86,"D",0.54,"-",0.586,2,"D","P",{"$nulls":9},"AA        : Amino Acid"]
[3,"A","L","L",7,0,76,0,72,1,1,0,8,"b","e","b","e",13,7,83,7,7,9,13,16,20,22,23,25,24,3,"A",0.1,"-",0.83,"D",0.36,"-",0.556,1,"D","-",{"$nulls":9},"OHEL      : observed secondary structure: H=helix, E=extended (sheet), blank=other (loop)"]
[4,"H","L","L",5,0,132,0,72,2,1,1,7,"b","e","b","e",20,11,73,7,7,9,13,16,19,22,24,26,25,4,"H",0.12,"-",0.84,"D",0.29,"-",0.505,0,"-","P",{"$nulls":9},"PHEL      : PROF predicted secondary structure: H=helix, E=extended (sheet), blank=other (loop) PROF = PROF: Profile network prediction HeiDelberg"]
[5,"R","L","L",6,0,104,0,42,3,1,0,7,"b","e","b","e",15,10,77,6,7,10,15,20,25,27,24,20,16,5,"R",0.11,"-",0.7,"D",0.34,"-",0.455,2,"-","-",{"$nulls":9},"RI_S      : reliability index for PROFsec prediction (0=lo 9=high) Note: for the brief presentation strong predictions marked by '*'"]
[6,"P","L","L",1,0,40,0,30,1,3,0,5,"b","e","b","i",41,5,57,16,16,17,19,21,22,21,18,15,13,6,"P",0.09,"-",0.62,"D",0.34,"-",0.424,3,"-","-",{"$nulls":9},"OACC      : observed solvent accessibility (acc) in square Angstroem (taken from DSSP: W Kabsch and C Sander, Biopolymers, 22, 2577-2637, 1983)"]
[7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",69,4,33,13,14,16,19,20,20,18,16,12,10,7,"V",0.21,"-",0.61,"D",0.28,"-",0.354,5,"-","-",{"$nulls":9},"PACC      : PROF predicted solvent accessibility (acc) in square Angstroem"]
[8,"E","L","H",6,0,108,0,56,2,7,0,1,"b","e","b","e",81,7,15,7,8,9,12,16,20,24,25,21,17,8,"E",0.26,"-",0.54,"D",0.23,"-",0.313,6,"-","-",{"$nulls":9},"OREL      : observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%)."]
[9,"W","L","H",8,0,0,0,0,3,8,0,0,"b","b","b","b",90,4,7,31,28,24,21,18,14,9,5,2,1,9,"W",0.21,"-",0.39,"-",0.26,"-",0.313,6,"-","-",{"$nulls":9},"PREL      : PROF predicted relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%)."]
[10,"V","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",91,3,6,41,33,19,14,10,7,4,2,1,0,10,"V",0.12,"-",0.3,"-",0.26,"-",0.303,7,"-","-",{"$nulls":9},"RI_A      : reliability index for PROFacc prediction (0=low to 9=high) Note: for the brief presentation strong predictions marked by '*'"]
[11,"Q","L","H",8,0,59,0,30,1,9,0,0,"b","e","b","i",93,1,5,16,16,17,20,22,23,20,14,7,3,11,"Q",0.1,"-",0.28,"-",0.18,"-",0.333,6,"-","-",{"$nulls":9},"pH        : 'probability' for assigning helix (1=high, 0=low)"]
[12,"A","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",93,1,5,24,23,21,21,21,19,15,10,5,2,12,"A",0.13,"-",0.27,"-",0.25,"-",0.333,6,"-","-",{"$nulls":9},"pE        : 'probability' for assigning strand (1=high, 0=low)"]
[13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,46,35,16,9,6,3,2,1,0,0,13,"V",0.11,"-",0.24,"-",0.25,"-",0.323,6,"-","-",{"$nulls":9},"pL        : 'probability' for assigning neither helix, nor strand (1=high, 0=low)"]
[14,"V","L","H",9,0,0,0,0,5,9,0,0,"b","b","b","b",95,1,3,34,29,20,16,13,10,6,4,2,1,14,"V",0.12,"-",0.32,"-",0.37,"-",0.323,6,"-","-",{"$nulls":9},"Obe       : observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%."]
[15,"S","L","H",8,0,54,0,42,3,9,0,0,"b","e","b","e",91,1,7,8,9,11,14,18,22,24,21,14,9,15,"S",0.14,"-",0.41,"-",0.33,"-",0.354,5,"-","-",{"$nulls":9},"Pbe       : PROF predicted  relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%."]
[16,"R","L","H",7,0,29,0,12,3,8,0,0,"b","b","b","i",89,2,10,15,18,22,26,26,22,16,9,4,2,16,"R",0.14,"-",0.39,"-",0.33,"-",0.343,5,"-","-",{"$nulls":9},"Obie      : observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%."]
[17,"F","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",90,1,9,42,34,21,13,9,6,4,2,1,0,17,"F",0.21,"-",0.41,"-",0.26,"-",0.323,6,"-","-",{"$nulls":9},"Pbie      : PROF predicted relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%."]
[18,"D","L","H",7,0,68,0,42,2,8,0,1,"b","e","b","e",88,2,11,11,12,14,17,20,23,24,21,15,11,18,"D",0.24,"-",0.6,"D",0.44,"-",0.343,5,"-","-",{"$nulls":9},"OtH       : actual neural network output from PROFsec for helix unit"]
[19,"E","L","H",4,0,139,0,72,3,6,0,2,"b","e","b","e",72,3,28,4,5,6,9,12,16,21,26,27,26,19,"E",0.29,"-",0.59,"D",0.55,"-",0.333,6,"-","-",{"$nulls":9},"OtE       : actual neural network output from PROFsec for strand unit"]
[20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",57,4,42,8,10,14,19,23,25,24,20,14,9,20,"Q",0.29,"-",0.6,"D",0.49,"-",0.323,6,"-","-",{"$nulls":9},"OtL       : actual neural network output from PROFsec for 'no-regular' unit"]
[21,"L","L","L",6,0,3,0,2,3,1,0,8,"b","b","b","b",15,5,81,28,29,28,25,19,13,8,5,3,2,21,"L",0.32,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":9},"Ot4       : actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!"]
[22,"P","L","L",7,0,76,0,56,2,1,0,8,"b","e","b","e",11,7,83,13,12,12,13,16,20,23,24,22,19,22,"P",0.37,"-",0.58,"D",0.71,"D",0.323,6,"-","-"]
[23,"I","L","L",5,0,20,0,12,2,1,1,7,"b","b","b","i",17,13,73,17,20,23,24,22,18,14,11,11,11,23,"I",0.36,"-",0.54,"D",0.66,"D",0.313,6,"-","-"]
[24,"K","L","L",5,0,114,0,56,3,1,1,6,"b","e","b","e",18,15,70,5,5,7,10,14,18,22,25,25,24,24,"K",0.39,"-",0.56,"D",0.57,"-",0.354,5,"-","-",{"$nulls":9},"Note: PREL definition (see above; copied from the output file) and numbers (see column I) do not match: values are not 0 to 9.  Values of nˆ2 for n=0 to 9 are 0%, 1%, 4%, 9%, 16%, 25%, 36%, 49%, 64%, 81%."]
[25,"T","L","L",6,0,102,0,72,1,1,1,7,"b","e","b","e",13,11,77,11,11,11,13,16,19,21,22,23,23,25,"T",0.41,"-",0.56,"D",0.5,"-",0.394,4,"-","-"]
[26,"G","L","L",7,0,10,0,12,0,0,1,8,"b","b","b","i",9,11,81,20,20,20,21,20,19,17,16,15,14,26,"G",0.4,"-",0.49,"D",0.66,"D",0.455,2,"-","-",{"$nulls":9},"Key for output (columns AE to AP)"]
[27,"Q","L","L",6,0,83,0,42,0,1,1,7,"b","e","b","e",13,11,76,11,12,14,17,19,21,22,22,21,20,27,"Q",0.44,"-",0.58,"D",0.76,"D",0.485,1,"-","-",{"$nulls":9},"----------------"]
[28,"Q","L","L",4,0,83,0,42,0,2,1,6,"b","e","b","e",22,15,63,10,11,13,16,18,20,21,21,21,20,28,"Q",0.52,"D",0.62,"D",0.77,"D",0.515,0,"-","-",{"$nulls":9},"Number - residue number"]
[29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",27,17,61,12,12,13,16,18,20,21,21,20,19,29,"N",0.42,"-",0.61,"D",0.66,"D",0.52,0,"D","-",{"$nulls":9},"Residue - amino-acid type"]
[30,"T","L","L",2,0,28,0,20,0,2,1,5,"b","e","b","i",30,16,59,16,16,17,19,20,20,19,17,15,13,30,"T",0.4,"-",0.56,"D",0.66,"D",0.485,1,"-","-",{"$nulls":9},"NORSnet - raw score by NORSnet (prediction of unstructured loops)"]
[31,"H","L","L",1,0,77,0,42,1,3,1,5,"b","e","b","e",35,14,54,11,12,13,16,18,20,21,20,18,17,31,"H",0.37,"-",0.6,"D",0.76,"D",0.525,0,"D","-",{"$nulls":9},"NORS2st - two-state prediction by NORSnet; D=disordered"]
[32,"T","L","L",1,0,59,0,42,0,3,1,5,"b","e","b","e",40,13,53,12,12,13,16,18,19,20,20,19,18,32,"T",0.28,"-",0.59,"D",0.7,"D",0.49,1,"-","-",{"$nulls":9},"PROFbval - raw score by PROFbval (prediction of residue flexibility from sequence)"]
[33,"K","L","H",0,0,86,0,42,1,4,1,4,"b","e","b","e",46,13,46,8,9,10,13,16,20,22,22,20,18,33,"K",0.34,"-",0.46,"-",0.68,"D",0.52,0,"D","-",{"$nulls":9},"Bval2st - two-state prediction by PROFbval"]
[34,"V","L","H",1,0,28,0,20,0,5,0,3,"b","e","b","i",53,10,38,14,15,16,18,20,20,20,18,16,14,34,"V",0.28,"-",0.56,"D",0.79,"D",0.525,0,"D","-",{"$nulls":9},"Ucon - raw score by Ucon (prediction of protein disorder using predicted internal contacts)"]
[35,"S","L","H",2,0,39,0,30,0,5,0,3,"b","e","b","i",60,9,33,17,17,16,18,19,20,19,18,14,12,35,"S",0.23,"-",0.5,"D",0.86,"D",0.434,2,"-","-",{"$nulls":9},"Ucon2st - two-state prediction by Ucon"]
[36,"T","L","H",3,0,28,0,20,0,6,0,2,"b","e","b","i",67,6,29,19,19,19,20,21,21,19,15,11,8,36,"T",0.19,"-",0.54,"D",0.77,"D",0.424,3,"-","-",{"$nulls":9},"MD - raw score by MD (prediction of protein disorder using orthogonal sources)"]
[37,"E","L","H",5,0,108,0,56,3,7,0,2,"b","e","b","e",74,6,21,5,5,7,10,14,18,23,26,24,22,37,"E",0.15,"-",0.58,"D",0.62,"D",0.404,3,"-","-",{"$nulls":9},"MD_rel - reliability of the prediction by MD; values range from 0-9. 9=strong prediction"]
[38,"H","L","H",4,0,36,0,20,1,6,0,2,"b","e","b","i",72,8,23,17,17,18,20,22,22,20,16,12,9,38,"H",0.14,"-",0.49,"D",0.35,"-",0.303,7,"-","-",{"$nulls":9},"MD2st - two-state prediction by MD"]
[39,"N","L","H",4,0,0,0,0,4,7,0,2,"b","b","b","b",73,6,24,31,27,20,17,15,12,10,8,5,4,39,"N",0.14,"-",0.38,"-",0.47,"-",0.313,6,"-","-"]
[40,"K","L","H",6,0,61,0,30,2,8,0,1,"b","e","b","i",83,4,15,12,13,15,19,22,24,23,19,13,9,40,"K",0.15,"-",0.42,"-",0.33,"-",0.313,6,"-","-"]
[41,"E","L","H",6,0,81,0,42,1,8,0,1,"b","e","b","e",82,5,15,12,13,14,17,19,22,23,22,18,15,41,"E",0.17,"-",0.47,"D",0.36,"-",0.313,6,"-","-"]
[42,"C","L","H",6,0,0,0,0,3,7,1,1,"b","b","b","b",77,13,13,30,27,23,20,17,14,10,6,3,2,42,"C",0.19,"-",0.3,"-",0.41,"-",0.283,7,"-","-"]
[43,"L","L","H",5,0,0,0,0,8,6,1,1,"b","b","b","b",74,18,14,41,33,19,13,10,7,5,3,2,2,43,"L",0.19,"-",0.28,"-",0.32,"-",0.273,8,"-","-"]
[44,"I","L","H",4,0,0,0,0,3,6,2,1,"b","b","b","b",67,21,17,31,28,22,18,15,11,9,6,4,3,44,"I",0.11,"-",0.4,"-",0.4,"-",0.263,8,"-","-"]
[45,"N","L","H",4,0,47,0,30,1,6,1,2,"b","e","b","i",67,18,22,17,17,17,20,21,22,20,16,11,8,45,"N",0.08,"-",0.39,"-",0.21,"-",0.26,8,"-","-"]
[46,"I","L","H",3,0,0,0,0,5,6,1,2,"b","b","b","b",63,12,28,35,30,22,17,14,10,7,4,3,2,46,"I",0.08,"-",0.4,"-",0.2,"-",0.253,8,"-","-"]
[47,"S","L","H",1,0,0,0,0,4,5,0,4,"b","b","b","b",52,9,42,34,29,21,18,15,12,9,6,5,4,47,"S",0.06,"-",0.44,"-",0.19,"-",0.263,8,"-","-"]
[48,"K","L","H",2,0,86,0,42,1,6,0,3,"b","e","b","e",63,6,35,14,13,14,16,19,21,23,22,20,18,48,"K",0.07,"-",0.57,"D",0.2,"-",0.27,8,"-","-"]
[49,"Y","L","H",1,0,26,0,12,1,5,0,4,"b","b","b","i",56,5,42,18,19,20,23,23,21,17,13,9,7,49,"Y",0.09,"-",0.49,"D",0.2,"-",0.263,8,"-","-"]
[50,"K","L","H",2,0,41,0,20,1,5,0,3,"b","e","b","i",61,6,38,17,17,17,20,21,21,19,15,10,8,50,"K",0.1,"-",0.47,"D",0.2,"-",0.263,8,"-","-"]
[51,"F","L","H",5,0,0,0,0,5,7,0,2,"b","b","b","b",75,4,23,35,31,23,18,14,11,7,5,3,2,51,"F",0.12,"-",0.34,"-",0.26,"-",0.253,8,"-","-"]
[52,"S","L","H",6,0,0,0,0,2,8,0,1,"b","b","b","b",84,4,16,26,23,20,19,18,16,13,10,6,4,52,"S",0.1,"-",0.33,"-",0.18,"-",0.25,9,"-","-"]
[53,"L","L","H",8,0,0,0,0,4,8,0,0,"b","b","b","b",91,4,7,32,27,19,16,13,11,8,5,3,2,53,"L",0.15,"-",0.28,"-",0.15,"-",0.25,9,"-","-"]
[54,"V","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",93,3,5,46,36,17,11,7,4,2,1,0,0,54,"V",0.1,"-",0.26,"-",0.18,"-",0.242,9,"-","-"]
[55,"I","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,2,4,43,34,16,10,7,4,2,1,0,0,55,"I",0.07,"-",0.26,"-",0.13,"-",0.253,8,"-","-"]
[56,"S","L","H",8,0,0,0,0,2,9,0,0,"b","b","b","b",94,2,5,26,24,20,18,17,15,12,8,5,3,56,"S",0.07,"-",0.33,"-",0.13,"-",0.27,8,"-","-"]
[57,"G","L","H",8,0,0,0,0,5,9,0,0,"b","b","b","b",93,1,6,33,28,18,15,13,10,7,4,2,1,57,"G",0.08,"-",0.25,"-",0.14,"-",0.253,8,"-","-"]
[58,"L","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,0,3,47,36,15,8,5,3,1,0,0,0,58,"L",0.09,"-",0.26,"-",0.18,"-",0.263,8,"-","-"]
[59,"T","L","H",9,0,0,0,0,3,9,0,0,"b","b","b","b",95,1,3,28,25,20,18,16,13,9,6,3,2,59,"T",0.09,"-",0.34,"-",0.18,"-",0.273,8,"-","-"]
[60,"T","L","H",8,0,42,0,30,3,9,0,0,"b","e","b","i",92,1,7,10,11,13,17,21,24,23,18,11,6,60,"T",0.14,"-",0.4,"-",0.24,"-",0.283,7,"-","-"]
[61,"I","L","H",8,0,0,0,0,3,9,0,0,"b","b","b","b",92,1,7,31,27,21,18,15,11,7,4,1,0,61,"I",0.16,"-",0.35,"-",0.24,"-",0.293,7,"-","-"]
[62,"L","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",93,1,5,44,34,18,11,7,4,3,2,1,0,62,"L",0.18,"-",0.37,"-",0.19,"-",0.273,8,"-","-"]
[63,"K","L","H",8,0,114,0,56,3,9,0,0,"b","e","b","e",91,2,8,5,6,8,11,15,21,26,27,21,15,63,"K",0.14,"-",0.51,"D",0.28,"-",0.29,7,"-","-"]
[64,"N","L","H",6,0,47,0,30,2,7,0,1,"b","e","b","i",79,3,18,11,12,14,18,21,23,22,18,13,9,64,"N",0.21,"-",0.57,"D",0.21,"-",0.3,7,"-","-"]
[65,"V","L","H",3,0,0,0,0,3,6,0,3,"b","b","b","b",67,3,30,33,30,24,20,16,11,7,4,2,2,65,"V",0.29,"-",0.52,"D",0.16,"-",0.303,7,"-","-"]
[66,"N","L","H",2,0,65,0,42,1,5,0,3,"b","e","b","e",63,5,40,14,14,14,16,18,20,21,21,19,17,66,"N",0.29,"-",0.56,"D",0.2,"-",0.323,6,"-","-"]
[67,"N","L","L",0,0,87,0,56,3,4,0,4,"b","e","b","e",49,6,52,4,6,8,12,15,19,23,25,24,22,67,"N",0.31,"-",0.65,"D",0.33,"-",0.343,5,"-","-"]
[68,"M","L","L",2,0,56,0,30,1,3,0,5,"b","e","b","i",38,10,58,12,13,16,19,20,21,20,18,16,15,68,"M",0.34,"-",0.64,"D",0.24,"-",0.384,4,"-","-"]
[69,"R","L","L",4,0,104,0,42,0,2,1,6,"b","e","b","e",26,14,68,8,9,11,15,18,21,22,22,21,19,69,"R",0.43,"-",0.64,"D",0.22,"-",0.354,5,"-","-"]
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[1886,"F","L","H",7,0,0,0,0,3,8,0,1,"b","b","b","b",84,8,11,31,27,20,18,16,13,9,6,3,2,1886,"F",0.16,"-",0.32,"-",0.17,"-",0.263,8,"-","-"]
[1888,"V","L","H",7,0,0,0,0,0,8,0,0,"b","b","b","b",87,5,8,23,22,21,21,20,17,13,9,5,3,1888,"V",0.12,"-",0.39,"-",0.13,"-",0.253,8,"-","-"]
[1889,"S","L","H",7,0,26,0,20,2,8,0,0,"b","e","b","i",86,5,10,16,16,18,21,23,23,19,13,7,4,1889,"S",0.14,"-",0.41,"-",0.13,"-",0.263,8,"-","-"]
[1891,"S","L","H",8,0,0,0,0,7,9,0,0,"b","b","b","b",90,2,8,37,30,17,13,10,7,5,3,2,1,1891,"S",0.14,"-",0.34,"-",0.19,"-",0.273,8,"-","-"]
[1892,"K","L","H",8,0,86,0,42,3,9,0,0,"b","e","b","e",91,1,8,9,9,10,13,17,22,25,25,19,15,1892,"K",0.18,"-",0.52,"D",0.3,"-",0.31,6,"-","-"]
[1894,"L","L","H",7,0,0,0,0,4,8,0,1,"b","b","b","b",85,3,12,34,29,22,18,15,11,8,5,3,2,1894,"L",0.21,"-",0.4,"-",0.37,"-",0.283,7,"-","-"]
[1895,"A","L","H",5,0,0,0,0,3,7,0,2,"b","b","b","b",75,3,25,30,26,20,18,16,14,11,10,8,7,1895,"A",0.21,"-",0.45,"-",0.36,"-",0.263,8,"-","-"]
[1897,"N","L","L",1,0,47,0,30,1,3,0,5,"b","e","b","i",39,4,58,7,8,11,16,20,23,23,22,19,17,1897,"N",0.19,"-",0.67,"D",0.18,"-",0.253,8,"-","-"]
[1898,"E","L","L",5,0,81,0,42,2,2,0,7,"b","e","b","e",21,3,78,7,7,9,13,17,21,22,21,18,15,1898,"E",0.16,"-",0.62,"D",0.22,"-",0.253,8,"-","-"]
[1900,"H","L","L",1,0,77,0,42,1,4,0,5,"b","e","b","e",43,7,53,12,12,13,16,18,21,23,22,20,17,1900,"H",0.14,"-",0.6,"D",0.17,"-",0.27,8,"-","-"]
[1901,"L","L","H",1,0,0,0,0,0,5,0,3,"b","b","b","b",56,8,38,25,25,23,22,19,16,12,8,5,4,1901,"L",0.16,"-",0.52,"D",0.21,"-",0.26,8,"-","-"]
[1903,"L","L","H",7,0,0,0,0,0,8,0,0,"b","b","b","b",87,3,9,24,24,23,23,20,16,11,7,4,3,1903,"L",0.17,"-",0.38,"-",0.16,"-",0.26,8,"-","-"]
[1904,"E","L","H",8,0,58,0,30,3,9,0,0,"b","e","b","i",90,3,6,9,10,14,19,22,24,21,16,10,6,1904,"E",0.2,"-",0.45,"-",0.13,"-",0.253,8,"-","-"]
[1907,"E","L","H",9,0,38,0,20,2,9,0,0,"b","e","b","i",94,0,4,14,15,17,21,24,24,20,14,7,3,1907,"E",0.1,"-",0.38,"-",0.14,"-",0.263,8,"-","-"]
[1908,"E","L","H",9,0,58,0,30,3,9,0,0,"b","e","b","i",94,1,4,9,10,14,19,23,25,23,18,12,7,1908,"E",0.12,"-",0.33,"-",0.17,"-",0.273,8,"-","-"]
[1910,"I","L","H",8,0,0,0,0,4,9,0,0,"b","b","b","b",90,2,8,33,29,21,17,13,9,6,4,2,1,1910,"I",0.17,"-",0.34,"-",0.26,"-",0.283,7,"-","-"]
[1911,"S","L","H",6,0,72,0,56,3,8,0,1,"b","e","b","e",84,2,15,6,7,8,10,14,19,25,27,22,18,1911,"S",0.15,"-",0.4,"-",0.4,"-",0.303,7,"-","-"]
[1913,"F","L","H",3,0,0,0,0,3,6,0,3,"b","b","b","b",63,5,33,32,30,25,21,16,11,6,4,3,2,1913,"F",0.17,"-",0.45,"-",0.25,"-",0.293,7,"-","-"]
[1914,"S","L","H",1,0,54,0,42,1,5,0,4,"b","e","b","e",58,4,42,11,12,13,15,18,21,23,23,21,19,1914,"S",0.13,"-",0.6,"D",0.24,"-",0.313,6,"-","-"]
[1916,"S","L","L",4,0,15,0,12,1,2,0,6,"b","b","b","i",27,6,68,17,19,21,22,21,18,15,13,12,11,1916,"S",0.12,"-",0.6,"D",0.4,"-",0.303,7,"-","-"]
[1917,"S","L","L",5,0,54,0,42,2,2,0,7,"b","e","b","e",21,4,78,9,9,10,14,18,22,24,23,20,17,1917,"S",0.13,"-",0.72,"D",0.29,"-",0.303,7,"-","-"]
[1919,"E","L","H",0,0,108,0,56,3,4,0,4,"b","e","b","e",49,4,49,6,6,8,11,14,18,22,26,26,26,1919,"E",0.15,"-",0.69,"D",0.21,"-",0.3,7,"-","-"]
[1920,"L","L","H",2,0,0,0,0,1,5,0,3,"b","b","b","b",58,5,38,24,23,21,20,19,16,13,10,8,7,1920,"L",0.18,"-",0.58,"D",0.2,"-",0.283,7,"-","-"]
[1922,"H","L","H",6,0,36,0,20,1,7,0,1,"b","e","b","i",77,7,17,16,17,18,21,22,22,19,15,10,7,1922,"H",0.24,"-",0.46,"-",0.13,"-",0.263,8,"-","-"]
[1923,"L","L","H",6,0,0,0,0,1,7,0,1,"b","b","b","b",77,9,16,25,24,22,21,19,16,13,9,6,4,1923,"L",0.24,"-",0.33,"-",0.15,"-",0.26,8,"-","-"]
[1925,"L","L","H",7,0,0,0,0,5,8,0,1,"b","b","b","b",83,6,10,35,30,21,16,13,10,7,5,3,2,1925,"L",0.16,"-",0.23,"-",0.14,"-",0.253,8,"-","-"]
[1926,"E","L","H",6,0,0,0,0,1,8,0,1,"b","b","b","b",80,7,13,26,24,22,20,18,16,12,8,5,4,1926,"E",0.12,"-",0.34,"-",0.13,"-",0.253,8,"-","-"]
[1929,"T","L","H",4,0,0,0,0,3,6,0,2,"b","b","b","b",70,5,28,29,27,22,19,15,12,8,5,3,2,1929,"T",0.07,"-",0.34,"-",0.14,"-",0.27,8,"-","-"]
[1930,"P","L","H",5,0,0,0,0,2,7,0,2,"b","b","b","b",78,5,21,25,23,19,18,17,16,14,11,8,6,1930,"P",0.09,"-",0.35,"-",0.14,"-",0.263,8,"-","-"]
[1932,"L","L","H",7,0,0,0,0,6,8,0,0,"b","b","b","b",86,5,10,39,33,21,16,11,7,4,2,1,1,1932,"L",0.09,"-",0.34,"-",0.13,"-",0.253,8,"-","-"]
[1933,"S","L","H",7,0,39,0,30,1,8,0,1,"b","e","b","i",85,5,12,17,16,16,19,21,23,21,16,11,7,1933,"S",0.09,"-",0.4,"-",0.13,"-",0.263,8,"-","-"]
[1935,"L","L","H",6,0,0,0,0,9,8,0,1,"b","b","b","b",83,6,14,43,34,19,12,8,5,3,1,0,0,1935,"L",0.14,"-",0.33,"-",0.14,"-",0.253,8,"-","-"]
[1936,"V","L","H",6,0,0,0,0,0,7,1,1,"b","b","b","b",79,11,15,22,21,20,20,20,18,16,14,11,9,1936,"V",0.14,"-",0.43,"-",0.17,"-",0.263,8,"-","-"]
[1938,"F","L","H",1,0,23,0,12,0,5,1,3,"b","b","b","i",53,17,35,19,19,19,20,20,19,15,12,9,7,1938,"F",0.24,"-",0.47,"D",0.29,"-",0.293,7,"-","-"]
[1939,"C","L","L",1,0,0,0,0,0,3,1,5,"b","b","b","b",34,16,53,25,24,23,22,20,16,12,8,6,5,1939,"C",0.25,"-",0.58,"D",0.25,"-",0.293,7,"-","-"]
[1941,"H","L","L",4,0,55,0,30,1,2,0,6,"b","e","b","i",21,10,70,10,11,15,19,22,23,21,19,17,16,1941,"H",0.21,"-",0.7,"D",0.65,"D",0.404,3,"-","-"]
[1942,"N","L","L",5,0,141,0,90,2,2,0,7,"b","e","b","e",21,6,74,6,6,8,10,13,16,20,23,27,29,1942,"N",0.26,"-",0.73,"D",0.67,"D",0.434,2,"-","-"]
[1944,"D","L","L",5,0,117,0,72,3,2,0,7,"b","e","b","e",22,5,74,5,6,8,11,14,17,21,24,28,28,1944,"D",0.2,"-",0.79,"D",0.88,"D",0.465,1,"-","-"]
[1945,"A","L","L",4,0,31,0,30,0,2,0,6,"b","e","b","i",22,8,69,11,12,14,18,20,21,21,20,18,16,1945,"A",0.24,"-",0.79,"D",0.78,"D",0.404,3,"-","-"]
[1947,"R","L","H",2,0,74,0,30,1,5,0,3,"b","e","b","i",61,2,39,12,12,14,18,20,22,22,20,16,13,1947,"R",0.22,"-",0.69,"D",0.61,"D",0.354,5,"-","-"]
[1948,"Q","L","H",4,0,110,0,56,2,6,0,2,"b","e","b","e",68,3,28,8,9,10,13,16,19,22,23,21,18,1948,"Q",0.22,"-",0.66,"D",0.37,"-",0.313,6,"-","-"]
[1950,"V","L","H",7,0,0,0,0,6,8,0,1,"b","b","b","b",87,1,13,37,30,19,15,12,9,6,3,1,1,1950,"V",0.2,"-",0.39,"-",0.54,"-",0.293,7,"-","-"]
[1951,"T","L","H",8,0,17,0,12,0,9,0,0,"b","b","b","i",93,1,6,19,19,20,21,21,18,14,10,5,3,1951,"T",0.17,"-",0.41,"-",0.28,"-",0.273,8,"-","-"]
[1954,"L","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,1,3,46,35,16,9,6,3,2,1,0,0,1954,"L",0.1,"-",0.26,"-",0.15,"-",0.273,8,"-","-"]
[1955,"D","L","H",9,0,48,0,30,3,9,0,0,"b","e","b","i",94,1,4,11,12,15,19,23,25,22,16,8,4,1955,"D",0.08,"-",0.34,"-",0.17,"-",0.283,7,"-","-"]
[1957,"L","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",91,2,7,43,34,19,12,8,4,2,1,0,0,1957,"L",0.09,"-",0.24,"-",0.15,"-",0.273,8,"-","-"]
[1958,"I","L","H",7,0,0,0,0,7,8,0,0,"b","b","b","b",89,3,10,38,31,19,14,10,7,5,3,1,0,1958,"I",0.09,"-",0.28,"-",0.21,"-",0.273,8,"-","-"]
[1960,"M","L","H",4,0,0,0,0,6,6,1,1,"b","b","b","b",65,18,20,36,30,21,16,12,9,6,3,2,1,1960,"M",0.11,"-",0.34,"-",0.37,"-",0.263,8,"-","-"]
[1961,"T","L","H",2,0,0,0,0,6,5,2,2,"b","b","b","b",55,26,24,36,30,20,16,14,11,7,5,3,2,1961,"T",0.11,"-",0.32,"-",0.21,"-",0.253,8,"-","-"]
[1963,"N","L","L",0,0,65,0,42,2,3,1,4,"b","e","b","e",39,19,42,12,12,13,16,19,22,23,22,18,16,1963,"N",0.09,"-",0.6,"D",0.32,"-",0.28,7,"-","-"]
[1964,"E","L","L",1,0,58,0,30,1,3,1,5,"b","e","b","i",37,13,52,10,11,13,16,20,22,22,20,17,15,1964,"E",0.12,"-",0.56,"D",0.35,"-",0.283,7,"-","-"]
[1966,"Q","L","L",3,0,110,0,56,1,3,1,5,"b","e","b","e",31,11,61,10,11,12,15,18,20,22,23,22,20,1966,"Q",0.12,"-",0.65,"D",0.38,"-",0.323,6,"-","-"]
[1967,"M","L","L",4,0,22,0,12,0,2,1,6,"b","b","b","i",25,12,65,19,19,20,21,20,18,15,13,12,10,1967,"M",0.13,"-",0.64,"D",0.49,"-",0.313,6,"-","-"]
[1969,"P","L","H",2,0,40,0,30,2,6,0,3,"b","e","b","i",64,3,36,12,13,14,17,19,21,20,18,14,11,1969,"P",0.14,"-",0.49,"D",0.39,"-",0.303,7,"-","-"]
[1970,"S","L","H",6,0,54,0,42,2,8,0,1,"b","e","b","e",83,3,16,8,9,11,14,17,20,22,21,17,14,1970,"S",0.13,"-",0.46,"-",0.21,"-",0.293,7,"-","-"]
[1972,"Q","L","H",8,0,0,0,0,4,9,0,0,"b","b","b","b",91,2,7,33,28,19,17,13,10,6,4,2,1,1972,"Q",0.13,"-",0.38,"-",0.25,"-",0.253,8,"-","-"]
[1973,"A","L","H",9,0,21,0,20,1,9,0,0,"b","e","b","i",94,1,4,15,16,17,20,22,22,19,14,8,4,1973,"A",0.16,"-",0.43,"-",0.24,"-",0.27,8,"-","-"]
[1976,"W","L","H",9,0,0,0,0,6,9,0,0,"b","b","b","b",94,2,4,38,32,21,16,11,8,5,3,1,1,1976,"W",0.19,"-",0.28,"-",0.21,"-",0.273,8,"-","-"]
[1977,"G","L","H",8,0,0,0,0,1,8,0,0,"b","b","b","b",90,3,8,22,21,19,18,18,17,15,13,9,6,1977,"G",0.14,"-",0.4,"-",0.19,"-",0.273,8,"-","-"]
[1979,"L","L","H",5,0,0,0,0,6,7,0,2,"b","b","b","b",76,2,24,36,30,21,16,12,9,6,4,3,2,1979,"L",0.09,"-",0.45,"-",0.15,"-",0.26,8,"-","-"]
[1980,"G","L","H",1,0,0,0,0,0,5,0,4,"b","b","b","b",57,4,42,24,23,22,22,20,18,15,12,10,9,1980,"G",0.08,"-",0.48,"D",0.14,"-",0.273,8,"-","-"]
[1982,"I","L","L",5,0,20,0,12,1,2,0,7,"b","b","b","i",21,4,75,17,18,20,21,21,18,15,12,10,9,1982,"I",0.09,"-",0.65,"D",0.17,"-",0.263,8,"-","-"]
[1983,"T","L","L",5,0,42,0,30,0,2,0,7,"b","e","b","i",24,5,76,13,13,14,17,19,21,21,20,18,16,1983,"T",0.12,"-",0.7,"D",0.14,"-",0.263,8,"-","-"]
[1985,"L","L","H",1,0,0,0,0,0,5,0,3,"b","b","b","b",56,8,39,23,23,22,21,20,18,15,11,8,7,1985,"L",0.15,"-",0.47,"D",0.16,"-",0.253,8,"-","-"]
[1986,"L","L","H",2,0,0,0,0,3,5,0,3,"b","b","b","b",61,8,33,30,27,21,18,15,12,9,6,3,2,1986,"L",0.13,"-",0.39,"-",0.16,"-",0.242,9,"-","-"]
[1988,"V","L","H",7,0,0,0,0,1,8,0,1,"b","b","b","b",82,7,12,25,24,22,21,19,16,11,7,4,2,1988,"V",0.13,"-",0.3,"-",0.14,"-",0.25,9,"-","-"]
[1989,"V","L","H",7,0,0,0,0,9,8,0,0,"b","b","b","b",86,6,10,43,34,18,11,8,5,3,1,0,0,1989,"V",0.13,"-",0.25,"-",0.15,"-",0.242,9,"-","-"]
[1991,"D","L","H",8,0,32,0,20,2,9,0,0,"b","e","b","i",94,1,5,16,17,19,22,24,24,20,14,7,4,1991,"D",0.07,"-",0.36,"-",0.25,"-",0.273,8,"-","-"]
[1992,"S","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",94,1,5,22,22,22,22,21,17,12,7,4,2,1992,"S",0.09,"-",0.34,"-",0.21,"-",0.273,8,"-","-"]
[1994,"I","L","H",9,0,0,0,0,6,9,0,0,"b","b","b","b",95,2,3,38,32,20,15,11,7,4,2,1,0,1994,"I",0.11,"-",0.29,"-",0.31,"-",0.273,8,"-","-"]
[1995,"K","L","H",8,0,61,0,30,2,9,0,0,"b","e","b","i",94,1,5,12,13,15,19,21,24,22,18,11,7,1995,"K",0.1,"-",0.4,"-",0.42,"-",0.3,7,"-","-"]
[1998,"A","L","H",4,0,0,0,0,1,7,0,2,"b","b","b","b",72,5,25,26,24,22,20,18,16,13,10,8,7,1998,"A",0.18,"-",0.47,"D",0.34,"-",0.293,7,"-","-"]
[1999,"T","L","H",2,0,79,0,56,1,5,0,3,"b","e","b","e",61,7,35,11,12,13,15,17,20,21,22,20,18,1999,"T",0.17,"-",0.59,"D",0.33,"-",0.303,7,"-","-"]
[2001,"G","L","L",4,0,47,0,56,3,2,0,6,"b","e","b","e",27,5,72,8,8,9,12,15,19,22,25,25,25,2001,"G",0.22,"-",0.68,"D",0.3,"-",0.3,7,"-","-"]
[2002,"L","L","L",5,0,19,0,12,2,2,0,7,"b","b","b","i",21,8,74,15,18,22,24,22,18,14,12,11,11,2002,"L",0.22,"-",0.7,"D",0.34,"-",0.273,8,"-","-"]
[2004,"S","L","L",5,0,93,0,72,1,2,0,7,"b","e","b","e",21,9,75,9,10,11,14,16,19,21,22,23,23,2004,"S",0.23,"-",0.64,"D",0.21,"-",0.263,8,"-","-"]
[2005,"I","L","L",3,0,33,0,20,1,2,1,6,"b","e","b","i",29,12,62,13,14,17,20,21,21,19,17,15,13,2005,"I",0.24,"-",0.59,"D",0.2,"-",0.263,8,"-","-"]
[2007,"A","L","H",3,0,12,0,12,0,6,0,2,"b","b","b","i",63,10,29,22,22,22,23,21,18,14,11,8,6,2007,"A",0.21,"-",0.49,"D",0.34,"-",0.283,7,"-","-"]
[2008,"E","L","H",5,0,108,0,56,2,7,1,1,"b","e","b","e",72,11,19,7,8,9,12,16,19,23,24,21,18,2008,"E",0.17,"-",0.48,"D",0.33,"-",0.29,7,"-","-"]
[2010,"M","L","H",6,0,0,0,0,6,7,1,1,"b","b","b","b",81,11,13,36,30,21,16,13,9,6,4,3,2,2010,"M",0.13,"-",0.34,"-",0.3,"-",0.27,8,"-","-"]
[2011,"A","L","H",6,0,31,0,30,1,7,0,1,"b","e","b","i",82,7,15,17,17,17,19,20,21,19,16,11,8,2011,"A",0.09,"-",0.42,"-",0.17,"-",0.273,8,"-","-"]
[2013,"T","L","H",5,0,0,0,0,6,7,1,1,"b","b","b","b",73,14,17,37,30,19,14,11,8,5,3,2,1,2013,"T",0.11,"-",0.28,"-",0.15,"-",0.263,8,"-","-"]
[2014,"A","L","H",5,0,0,0,0,7,6,1,1,"b","b","b","b",72,21,14,37,30,18,13,10,7,5,4,2,1,2014,"A",0.12,"-",0.27,"-",0.18,"-",0.263,8,"-","-"]
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[2791,"R","L","L",4,0,49,0,20,1,1,2,6,"b","e","b","i",13,24,67,14,15,17,20,22,22,20,18,15,13,2791,"R",0.46,"-",0.52,"D",0.59,"D",0.606,3,"D","-"]
[2792,"T","L","L",3,0,28,0,20,0,1,2,6,"b","e","b","i",16,25,63,18,18,18,20,21,21,19,17,14,12,2792,"T",0.53,"D",0.47,"D",0.74,"D",0.622,4,"D","-"]
[2793,"R","L","L",3,0,29,0,12,0,1,2,5,"b","b","b","i",16,29,60,19,20,21,22,21,20,16,13,9,8,2793,"R",0.52,"D",0.39,"-",0.76,"D",0.633,4,"D","-"]
[2794,"H","L","L",4,0,0,0,0,0,1,2,6,"b","b","b","b",16,24,66,22,21,21,21,20,19,16,13,11,9,2794,"H",0.57,"D",0.42,"-",0.66,"D",0.626,4,"D","-"]
[2795,"G","L","L",4,0,10,0,12,0,2,1,6,"b","b","b","i",22,18,69,20,20,20,21,21,20,18,16,14,12,2795,"G",0.6,"D",0.49,"D",0.73,"D",0.646,5,"D","-"]
[2796,"S","L","L",4,0,0,0,0,0,2,1,6,"b","b","b","b",27,16,67,22,21,20,20,20,19,18,16,14,12,2796,"S",0.66,"D",0.46,"-",0.83,"D",0.646,5,"D","-"]
[2797,"A","L","L",1,0,0,0,0,0,3,1,5,"b","b","b","b",43,13,56,24,22,20,21,20,19,17,15,14,13,2797,"A",0.71,"D",0.41,"-",0.87,"D",0.646,5,"D","-"]
[2798,"S","L","L",1,0,39,0,30,0,3,1,5,"b","e","b","i",42,11,57,13,14,15,18,20,21,21,21,20,19,2798,"S",0.68,"D",0.57,"D",0.87,"D",0.653,5,"D","-"]
[2799,"Q","L","L",1,0,83,0,42,0,3,1,5,"b","e","b","e",39,13,55,8,10,12,16,19,22,23,23,22,20,2799,"Q",0.67,"D",0.66,"D",0.9,"D",0.653,5,"D","-"]
[2800,"V","L","L",2,0,28,0,20,1,3,1,5,"b","e","b","i",34,17,56,16,16,17,19,21,21,19,17,16,15,2800,"V",0.68,"D",0.62,"D",0.91,"D",0.636,4,"D","-"]
[2801,"Q","L","L",4,0,83,0,42,1,2,1,5,"b","e","b","e",24,21,64,12,12,14,17,20,21,22,20,18,17,2801,"Q",0.68,"D",0.69,"D",0.88,"D",0.643,5,"D","-"]
[2802,"K","L","L",5,0,147,0,72,2,1,1,6,"b","e","b","e",19,18,71,7,8,10,13,16,20,23,26,27,26,2802,"K",0.67,"D",0.67,"D",0.9,"D",0.646,5,"D","-"]
[2803,"Q","L","L",5,0,110,0,56,1,1,1,6,"b","e","b","e",16,16,74,7,8,11,15,19,21,22,23,22,21,2803,"Q",0.59,"D",0.61,"D",0.79,"D",0.643,5,"D","-"]
[2804,"R","L","L",5,0,138,0,56,1,1,1,6,"b","e","b","e",19,16,72,9,9,11,15,18,21,23,24,23,22,2804,"R",0.6,"D",0.64,"D",0.87,"D",0.667,6,"D","-"]
[2805,"S","L","L",5,0,26,0,20,0,1,1,6,"b","e","b","i",19,13,73,17,17,18,20,21,20,19,18,17,17,2805,"S",0.62,"D",0.59,"D",0.93,"D",0.667,6,"D","-"]
[2806,"A","L","L",4,0,31,0,30,0,2,1,6,"b","e","b","i",27,12,68,13,13,14,18,19,21,21,20,21,20,2806,"A",0.62,"D",0.61,"D",0.92,"D",0.667,6,"D","-"]
[2807,"G","L","L",4,0,25,0,30,0,2,1,6,"b","e","b","i",27,13,67,15,15,16,19,20,22,22,21,20,18,2807,"G",0.6,"D",0.53,"D",0.85,"D",0.667,6,"D","-"]
[2808,"S","L","L",3,0,0,0,0,0,2,1,5,"b","b","b","b",31,14,65,21,20,19,20,20,20,18,17,15,14,2808,"S",0.59,"D",0.53,"D",0.73,"D",0.657,5,"D","-"]
[2809,"F","L","L",2,0,0,0,0,0,2,2,4,"b","b","b","b",32,23,53,25,25,23,22,19,16,12,10,9,8,2809,"F",0.7,"D",0.6,"D",0.83,"D",0.657,5,"D","-"]
[2810,"K","L","L",2,0,86,0,42,1,2,1,5,"b","e","b","e",31,19,58,8,8,10,14,17,21,24,24,22,20,2810,"K",0.61,"D",0.58,"D",0.91,"D",0.657,5,"D","-"]
[2811,"R","L","L",1,0,74,0,30,1,3,1,5,"b","e","b","i",39,14,55,7,9,13,18,21,23,23,21,18,16,2811,"R",0.72,"D",0.63,"D",0.86,"D",0.657,5,"D","-"]
[2812,"N","L","L",0,0,113,0,72,1,4,0,4,"b","e","b","e",46,11,55,6,7,9,13,16,19,21,23,25,25,2812,"N",0.37,"-",0.72,"D",0.83,"D",0.657,5,"D","-"]
[2813,"S","L","L",0,0,72,0,56,1,4,1,4,"b","e","b","e",55,14,47,9,10,12,16,18,20,22,23,23,22,2813,"S",0.29,"-",0.58,"D",0.8,"D",0.653,5,"D","-"]
[2814,"I","L","L",0,0,50,0,30,0,4,1,4,"b","e","b","i",54,15,47,14,14,15,17,19,20,20,19,19,18,2814,"I",0.43,"-",0.58,"D",0.91,"D",0.646,5,"D","-"]
[2815,"K","L","L",0,0,147,0,72,3,3,1,4,"b","e","b","e",44,18,51,2,2,5,8,13,17,23,26,28,28,2815,"K",0.3,"-",0.7,"D",0.81,"D",0.657,5,"D","-"]
[2816,"K","L","L",2,0,147,0,72,2,2,2,4,"b","e","b","e",33,25,54,5,5,7,10,14,18,22,25,27,27,2816,"K",0.35,"-",0.8,"D",0.77,"D",0.582,2,"D","-"]
[2817,"I","L","L",4,0,20,0,12,1,1,2,6,"b","b","b","i",18,22,64,16,17,18,21,20,18,15,13,13,13,2817,"I",0.35,"-",0.77,"D",0.77,"D",0.582,2,"D","-"]
[2818,"V","L","L",8,0,127,0,90,3,0,0,8,"b","e","b","e",3,8,90,7,7,7,9,11,13,15,17,25,28,2818,"V",0.38,"-",0.84,"D",0.74,"D",0.545,1,"D","-"]

{"sheet":"delE9","index":1,"n_rows":2864,"n_cols":69,"rows_kept":2250,"cut":true,"merged":[[0,2,0,43],[7,68,10,118],[14,68,20,118],[24,68,30,118],[33,68,35,118],[1175,0,1572,0],[2822,54,2834,55]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
[null,null,"delE9"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE9)"]
[null,1,1,"M","L","L",9,0,169,0,90,3,0,0,9,"b","e","b","e",1,1,96,9,8,8,10,11,13,14,16,23,27,1,"M",0.32,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE9!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",9,8,85,7,7,8,11,14,17,19,20,25,27,2,"A",0.22,"-",0.86,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE9!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",7,0,76,0,72,1,1,0,8,"b","e","b","e",12,8,82,8,8,9,13,16,19,22,23,24,24,3,"A",0.09,"-",0.82,"D",0.36,"-",0.545,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE9!I5","v":0},{"$nulls":12},"SUMMARY: "]
[null,4,4,"H","L","L",5,0,132,0,72,1,1,1,7,"b","e","b","e",19,12,73,7,8,10,14,16,20,22,24,25,24,4,"H",0.12,"-",0.83,"D",0.29,"-",0.495,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE9!I6","v":0}]
[null,5,5,"R","L","L",6,0,104,0,42,2,1,1,7,"b","e","b","e",15,11,77,8,9,11,16,20,24,25,23,21,18,5,"R",0.1,"-",0.7,"D",0.34,"-",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE9!I7","v":0}]
[null,6,6,"P","L","L",2,0,40,0,30,2,3,0,5,"b","e","b","i",36,7,63,14,14,15,18,21,23,22,19,16,13,6,"P",0.09,"-",0.64,"D",0.34,"-",0.404,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE9!I8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (4%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of full length neurofibromin. All predicted changes in secondary structure have very low (RI_S = 0-1) or low relibility (RI_S = 2-3). "]
[null,7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",67,4,33,14,15,17,20,21,21,18,15,12,9,7,"V",0.21,"-",0.58,"D",0.28,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE9!I9","v":0}]
[null,8,8,"E","L","H",5,0,108,0,56,3,7,0,1,"b","e","b","e",77,7,18,6,7,8,11,15,19,24,26,22,19,8,"E",0.26,"-",0.55,"D",0.23,"-",0.31,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE9!I10","v":0}]
[null,9,9,"W","L","H",8,0,0,0,0,2,8,0,0,"b","b","b","b",89,4,9,30,27,24,22,20,15,10,6,3,1,9,"W",0.23,"-",0.4,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE9!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",90,3,7,41,33,19,14,10,7,4,2,1,0,10,"V",0.13,"-",0.32,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE9!I12","v":0}]
[null,11,11,"Q","L","H",8,0,39,0,20,2,9,0,0,"b","e","b","i",92,1,5,17,17,18,22,24,24,19,13,6,3,11,"Q",0.1,"-",0.27,"-",0.18,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE9!I13","v":20}]
[null,12,12,"A","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",92,1,6,24,23,21,21,20,18,14,10,5,2,12,"A",0.13,"-",0.26,"-",0.25,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE9!I14","v":0}]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,47,35,15,8,5,3,2,1,0,0,13,"V",0.12,"-",0.23,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE9!I15","v":0},{"$nulls":12},"2. Solvent Accessibility: 359 residues (13%) are predicted to have changed their classification (according to Pbie or Pbe, with b=burried, i=intermediate, e=exposed). All predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-4). NF1delE9 could have a solvent accessibility that is reduced beyond what can be attributed to the deleted exon. "]
[null,14,14,"V","L","H",9,0,0,0,0,5,9,0,0,"b","b","b","b",95,1,3,35,30,20,16,12,9,6,4,2,1,14,"V",0.13,"-",0.32,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE9!I16","v":0}]
[null,15,15,"S","L","H",8,0,39,0,30,2,9,0,0,"b","e","b","i",91,2,7,12,13,14,18,21,23,22,18,11,7,15,"S",0.14,"-",0.4,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE9!I17","v":15}]
[null,16,16,"R","L","H",8,0,29,0,12,3,8,0,0,"b","b","b","i",90,2,9,15,18,23,26,26,22,16,9,4,2,16,"R",0.13,"-",0.37,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE9!I18","v":0}]
[null,17,17,"F","L","H",8,0,0,0,0,7,8,0,0,"b","b","b","b",90,2,10,40,33,21,15,11,7,4,2,1,1,17,"F",0.19,"-",0.41,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE9!I19","v":0}]
[null,18,18,"D","L","H",7,0,0,0,0,0,8,0,1,"b","b","b","b",87,3,13,20,19,19,20,20,19,18,15,12,9,18,"D",0.23,"-",0.6,"D",0.44,"-",0.34,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE9!I20","v":68}]
[null,19,19,"E","L","H",4,0,108,0,56,3,6,0,2,"b","e","b","e",71,3,29,5,5,7,9,13,17,22,26,26,25,19,"E",0.29,"-",0.59,"D",0.55,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE9!I21","v":31}]
[null,20,20,"Q","L","H",0,0,83,0,42,3,5,0,4,"b","e","b","e",52,5,46,5,7,11,16,20,24,26,24,19,14,20,"Q",0.31,"-",0.62,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE9!I22","v":-24}]
[null,21,21,"L","L","L",6,0,9,0,6,3,1,0,8,"b","b","b","b",14,5,81,26,26,27,25,21,15,9,5,3,2,21,"L",0.35,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE9!I23","v":-6}]
[null,22,22,"P","L","L",6,0,76,0,56,2,1,0,7,"b","e","b","e",16,6,79,12,12,11,13,16,21,24,25,22,19,22,"P",0.39,"-",0.55,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE9!I24","v":0}]
[null,23,23,"I","L","L",5,0,20,0,12,2,1,1,6,"b","b","b","i",18,14,71,16,19,22,24,22,18,14,12,12,11,23,"I",0.39,"-",0.55,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE9!I25","v":0},{"$nulls":12},"3. Disorder: 37 residues, predicted to be disordered in the full length protein, are predicted to be ordered in the protein produced by NF1delE9, while 6 residues are predicted to be disordered in the latter but not in neurofibromin. Out of those 37, 14 residues are in the CSRD. The biggest cluster of residues that are predicted to change from disordered to ordered are found within positions 801-813. Here 11 out of 13 residues are predicted to be ordered. This suggests that the exon deletion could potentially reduce the protein's flexibility in this area, possibly affecting protein function. However, with the exception of one such prediction that has medium reliability, predictions have very low to low reliability."]
[null,24,24,"K","L","L",5,0,114,0,56,3,1,1,6,"b","e","b","e",19,15,69,4,5,6,9,13,18,23,26,26,25,24,"K",0.4,"-",0.57,"D",0.57,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE9!I26","v":0}]
[null,25,25,"T","L","L",6,0,127,0,90,2,1,1,7,"b","e","b","e",14,12,75,9,9,9,11,14,17,20,23,26,27,25,"T",0.41,"-",0.56,"D",0.5,"-",0.388,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE9!I27","v":-25}]
[null,26,26,"G","L","L",6,0,10,0,12,0,0,1,7,"b","b","b","i",9,12,81,20,20,20,21,20,19,18,16,15,14,26,"G",0.42,"-",0.5,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE9!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,0,7,"b","e","b","e",11,10,80,11,11,13,16,18,20,22,22,22,21,27,"Q",0.44,"-",0.59,"D",0.76,"D",0.48,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE9!I29","v":0}]
[null,28,28,"Q","L","L",4,0,110,0,56,1,1,1,6,"b","e","b","e",19,15,66,10,11,13,16,18,20,21,22,21,20,28,"Q",0.49,"-",0.65,"D",0.77,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE9!I30","v":-27}]
[null,29,29,"N","L","L",3,0,47,0,30,0,2,1,6,"b","e","b","i",25,15,64,12,12,13,16,18,20,20,20,20,19,29,"N",0.41,"-",0.58,"D",0.66,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE9!I31","v":18}]
[null,30,30,"T","L","L",3,0,28,0,20,0,2,1,5,"b","e","b","i",30,14,60,15,15,16,18,20,20,19,17,15,14,30,"T",0.39,"-",0.56,"D",0.66,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE9!I32","v":0}]
[null,31,31,"H","L","L",2,0,77,0,42,1,3,1,5,"b","e","b","e",34,14,57,11,12,13,16,18,20,21,20,18,16,31,"H",0.36,"-",0.61,"D",0.76,"D",0.5,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE9!I33","v":0}]
[null,32,32,"T","L","L",1,0,42,0,30,0,3,1,5,"b","e","b","i",39,11,55,13,14,15,17,19,20,20,19,17,16,32,"T",0.28,"-",0.59,"D",0.7,"D",0.469,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE9!I34","v":17},{"$nulls":12},"4. Protein Binding: Deletion of E9 leads to 20 newly predicted potential protein binding sites (CSRD: three; GRD: four; Sec14&PH: one), while 19 potential binding sites, predicted in full length NF1, are now predicted to be lost (CSRD: three; GRD: two; Sec14&PH: one) - in addition to those in the deleted exon.   "]
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[null,2778,2720,"V","L","L",3,0,28,0,20,1,2,1,5,"b","e","b","i",31,15,62,15,16,18,20,21,21,18,16,14,13,2720,"V",0.6,"D",0.64,"D",0.86,"D",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2780-delE9!I2780","v":0}]
[null,2779,2721,"E","L","L",3,0,81,0,42,0,2,1,6,"b","e","b","e",26,17,65,11,11,13,16,19,21,22,22,21,20,2721,"E",0.59,"D",0.67,"D",0.79,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2781-delE9!I2781","v":0}]
[null,2780,2722,"L","L","L",4,0,49,0,30,0,2,1,6,"b","e","b","i",25,15,66,14,14,15,17,19,21,21,21,20,19,2722,"L",0.56,"D",0.59,"D",0.64,"D",0.571,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2782-delE9!I2782","v":19}]
[null,2781,2723,"S","L","L",5,0,15,0,12,0,1,1,6,"b","b","b","i",16,18,72,20,20,20,21,21,20,18,16,14,12,2723,"S",0.58,"D",0.56,"D",0.44,"-",0.566,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2783-delE9!I2783","v":0}]
[null,2782,2724,"P","L","L",4,0,0,0,0,0,1,1,6,"b","b","b","b",21,19,67,21,20,20,21,21,20,18,17,15,13,2724,"P",0.57,"D",0.53,"D",0.44,"-",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2784-delE9!I2784","v":16}]
[null,2783,2725,"T","L","L",4,0,0,0,0,0,1,1,6,"b","b","b","b",18,21,67,21,21,20,20,20,19,18,16,14,12,2725,"T",0.57,"D",0.51,"D",0.54,"-",0.582,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2785-delE9!I2785","v":0}]
[null,2784,2726,"T","L","L",3,0,0,0,0,0,2,1,5,"b","b","b","b",23,20,61,21,20,20,21,20,19,17,15,13,12,2726,"T",0.62,"D",0.52,"D",0.44,"-",0.576,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2786-delE9!I2786","v":0}]
[null,2785,2727,"G","L","L",4,0,35,0,42,0,2,1,6,"b","e","b","e",22,16,66,15,14,14,16,18,20,21,21,21,21,2727,"G",0.62,"D",0.54,"D",0.6,"D",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2787-delE9!I2787","v":-10}]
[null,2786,2728,"H","L","L",4,0,55,0,30,0,2,1,6,"b","e","b","i",23,19,65,11,12,15,18,21,22,22,20,19,18,2728,"H",0.63,"D",0.54,"D",0.57,"-",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2788-delE9!I2788","v":0}]
[null,2787,2729,"C","L","L",5,0,27,0,20,1,1,1,6,"b","e","b","i",19,16,71,14,15,16,19,21,21,19,17,17,16,2729,"C",0.62,"D",0.49,"D",0.57,"-",0.576,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2789-delE9!I2789","v":0}]
[null,2788,2730,"N","L","L",5,0,113,0,72,0,1,1,7,"b","e","b","e",17,13,73,11,11,13,16,18,20,21,21,22,22,2730,"N",0.56,"D",0.43,"-",0.55,"-",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2790-delE9!I2790","v":28}]
[null,2789,2731,"S","L","L",5,0,39,0,30,0,1,1,6,"b","e","b","i",18,15,73,15,15,16,18,20,21,21,20,20,19,2731,"S",0.52,"D",0.53,"D",0.52,"-",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2791-delE9!I2791","v":54}]
[null,2790,2732,"G","L","L",5,0,10,0,12,0,1,1,6,"b","b","b","i",15,20,71,19,20,20,21,21,20,18,15,13,12,2732,"G",0.39,"-",0.41,"-",0.57,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2792-delE9!I2792","v":15}]
[null,2791,2733,"R","L","L",2,0,29,0,12,0,1,3,5,"b","b","b","i",15,34,59,20,20,21,22,21,20,17,13,10,8,2733,"R",0.45,"-",0.38,"-",0.59,"D",0.602,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2793-delE9!I2793","v":20}]
[null,2792,2734,"T","L","L",2,0,0,0,0,0,1,3,5,"b","b","b","b",16,34,57,24,23,21,21,19,17,14,11,9,7,2734,"T",0.51,"-",0.42,"-",0.74,"D",0.612,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2794-delE9!I2794","v":28}]
[null,2793,2735,"R","L","L",1,0,0,0,0,0,1,3,4,"b","b","b","b",17,37,52,22,22,22,22,21,19,15,11,8,6,2735,"R",0.55,"D",0.35,"-",0.76,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2795-delE9!I2795","v":29}]
[null,2794,2736,"H","L","L",2,0,0,0,0,0,1,3,5,"b","b","b","b",15,32,58,24,24,22,22,20,17,13,10,7,6,2736,"H",0.62,"D",0.4,"-",0.66,"D",0.622,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2796-delE9!I2796","v":0}]
[null,2795,2737,"G","L","L",3,0,0,0,0,0,1,2,5,"b","b","b","b",20,27,61,24,23,21,22,20,18,15,12,10,9,2737,"G",0.61,"D",0.41,"-",0.73,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2797-delE9!I2797","v":10}]
[null,2796,2738,"S","L","L",3,0,0,0,0,0,2,2,5,"b","b","b","b",24,23,63,23,22,20,20,20,19,17,15,13,12,2738,"S",0.66,"D",0.41,"-",0.83,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2798-delE9!I2798","v":0}]
[null,2797,2739,"A","L","L",2,0,0,0,0,1,3,1,5,"b","b","b","b",37,17,60,24,23,20,20,19,18,15,13,12,11,2739,"A",0.71,"D",0.4,"-",0.87,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2799-delE9!I2799","v":0}]
[null,2798,2740,"S","L","L",2,0,39,0,30,0,3,1,5,"b","e","b","i",35,15,63,13,14,15,18,20,21,21,21,21,20,2740,"S",0.67,"D",0.49,"D",0.87,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2800-delE9!I2800","v":0}]
[null,2799,2741,"Q","L","L",3,0,59,0,30,0,2,1,5,"b","e","b","i",32,15,62,10,11,13,16,19,22,22,22,21,20,2741,"Q",0.66,"D",0.64,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE9!I2801","v":24}]
[null,2800,2742,"V","L","L",5,0,17,0,12,0,1,1,6,"b","b","b","i",20,15,71,18,18,19,21,21,20,17,14,13,13,2742,"V",0.68,"D",0.68,"D",0.91,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE9!I2802","v":11}]
[null,2801,2743,"Q","L","L",5,0,83,0,42,0,1,1,6,"b","e","b","e",16,16,73,10,11,12,15,18,21,22,22,22,21,2743,"Q",0.7,"D",0.71,"D",0.88,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE9!I2803","v":0}]
[null,2802,2744,"K","L","L",5,0,114,0,56,1,1,1,7,"b","e","b","e",17,12,75,9,10,11,15,17,20,22,23,23,23,2744,"K",0.64,"D",0.77,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE9!I2804","v":33}]
[null,2803,2745,"Q","L","L",5,0,178,0,90,1,1,1,7,"b","e","b","e",18,13,73,5,6,9,12,16,19,22,24,26,27,2745,"Q",0.59,"D",0.71,"D",0.79,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE9!I2805","v":-68}]
[null,2804,2746,"R","L","L",5,0,138,0,56,1,1,1,7,"b","e","b","e",17,13,74,8,9,12,15,18,21,22,23,23,22,2746,"R",0.55,"D",0.72,"D",0.87,"D",0.673,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE9!I2806","v":0}]
[null,2805,2747,"S","L","L",5,0,39,0,30,0,1,1,6,"b","e","b","i",20,12,74,9,10,12,16,20,22,22,21,21,20,2747,"S",0.57,"D",0.65,"D",0.93,"D",0.677,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE9!I2807","v":-13}]
[null,2806,2748,"A","L","L",4,0,76,0,72,1,2,1,6,"b","e","b","e",26,12,68,10,11,12,15,16,18,20,21,24,24,2748,"A",0.61,"D",0.6,"D",0.92,"D",0.677,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE9!I2808","v":-45}]
[null,2807,2749,"G","L","L",4,0,25,0,30,0,2,1,6,"b","e","b","i",25,13,69,11,12,14,17,19,20,20,19,20,19,2749,"G",0.59,"D",0.51,"D",0.85,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE9!I2809","v":0}]
[null,2808,2750,"S","L","L",4,0,54,0,42,1,2,1,6,"b","e","b","e",26,14,68,15,15,15,17,19,22,23,22,19,16,2750,"S",0.59,"D",0.55,"D",0.73,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE9!I2810","v":-54}]
[null,2809,2751,"F","L","L",2,0,23,0,12,1,3,1,5,"b","b","b","i",33,20,54,19,20,21,23,22,20,17,15,13,12,2751,"F",0.68,"D",0.65,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE9!I2811","v":-23}]
[null,2810,2752,"K","L","L",2,0,86,0,42,1,3,1,5,"b","e","b","e",31,16,56,9,9,10,13,17,21,24,24,22,19,2752,"K",0.65,"D",0.64,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE9!I2812","v":0}]
[null,2811,2753,"R","L","H",0,0,104,0,42,2,4,1,4,"b","e","b","e",47,11,46,5,6,9,13,18,22,25,24,21,18,2753,"R",0.68,"D",0.65,"D",0.86,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE9!I2813","v":-30}]
[null,2812,2754,"N","L","H",0,0,113,0,72,1,5,0,4,"b","e","b","e",53,7,45,5,6,8,12,16,19,22,23,24,23,2754,"N",0.36,"-",0.75,"D",0.83,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE9!I2814","v":0}]
[null,2813,2755,"S","L","H",1,0,72,0,56,1,5,0,3,"b","e","b","e",56,10,43,9,9,11,14,17,19,22,23,23,22,2755,"S",0.29,"-",0.7,"D",0.8,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE9!I2815","v":0}]
[null,2814,2756,"I","L","H",0,0,70,0,42,0,4,0,4,"b","e","b","e",55,11,47,11,11,13,16,19,20,21,21,20,19,2756,"I",0.45,"-",0.64,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE9!I2816","v":-20}]
[null,2815,2757,"K","L","L",1,0,147,0,72,2,3,1,5,"b","e","b","e",39,14,57,3,4,7,10,15,19,24,26,27,25,2757,"K",0.36,"-",0.8,"D",0.81,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE9!I2817","v":0}]
[null,2816,2758,"K","L","L",3,0,184,0,90,2,2,1,5,"b","e","b","e",29,18,66,2,3,5,7,12,16,22,27,30,31,2758,"K",0.42,"-",0.82,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE9!I2818","v":-37}]
[null,2817,2759,"I","L","L",5,0,152,0,90,0,1,1,7,"b","e","b","e",17,14,76,8,9,12,15,19,19,19,18,19,20,2759,"I",0.36,"-",0.83,"D",0.77,"D",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE9!I2819","v":-132}]
[null,2818,2760,"V","L","L",8,0,127,0,90,4,0,0,9,"b","e","b","e",3,5,93,8,8,7,9,11,13,15,17,25,29,2760,"V",0.38,"-",0.87,"D",0.74,"D",0.541,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE9!I2820","v":0}]
[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":4432}]
[{"$nulls":55},{"$f":"SUM(BD1:BD2820)-SUM(BD299:BD356)","v":2746}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},58,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":113},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":145},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":305},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":83},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":359},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.040942028985507244,"d":"4%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.13007246376811593,"d":"13%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":185},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":121},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":45},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":8},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":83},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":28},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":2},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":6},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":20}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":37},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":19}]

{"sheet":"delE12","index":2,"n_rows":2864,"n_cols":69,"rows_kept":2250,"cut":true,"merged":[[0,2,0,43],[7,68,10,118],[14,68,20,118],[24,68,31,118],[34,68,36,118],[422,2,465,43],[1175,0,1572,0],[2822,54,2834,55]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
[null,null,"delE12"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE12)"]
[null,1,1,"M","L","L",9,0,169,0,90,4,0,0,9,"b","e","b","e",1,1,96,8,8,8,10,11,13,14,16,24,28,1,"M",0.32,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE12!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",9,8,85,7,7,8,11,14,17,19,20,25,26,2,"A",0.22,"-",0.85,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE12!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",6,0,76,0,72,1,1,0,7,"b","e","b","e",13,8,82,8,8,9,13,16,19,22,23,24,24,3,"A",0.1,"-",0.82,"D",0.36,"-",0.545,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE12!I5","v":0},{"$nulls":12},"SUMMARY: "]
[null,4,4,"H","L","L",5,0,132,0,72,1,1,1,7,"b","e","b","e",19,12,73,7,8,10,14,16,20,23,24,25,24,4,"H",0.12,"-",0.82,"D",0.29,"-",0.5,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE12!I6","v":0}]
[null,5,5,"R","L","L",6,0,104,0,42,2,1,1,7,"b","e","b","e",15,11,76,7,8,11,15,19,23,25,24,21,18,5,"R",0.1,"-",0.69,"D",0.34,"-",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE12!I7","v":0}]
[null,6,6,"P","L","L",2,0,40,0,30,2,3,0,5,"b","e","b","i",36,7,61,14,14,15,18,21,22,22,19,15,13,6,"P",0.09,"-",0.64,"D",0.34,"-",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE12!I8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (3%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of neurofibromin. All predicted changes in secondary structure have very low or low relibility (RI_S = 0-3). "]
[null,7,7,"V","L","H",2,0,28,0,20,1,6,0,3,"b","e","b","i",65,4,36,14,15,17,20,21,21,18,16,12,10,7,"V",0.21,"-",0.6,"D",0.28,"-",0.35,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE12!I9","v":0}]
[null,8,8,"E","L","H",5,0,108,0,56,3,7,0,1,"b","e","b","e",77,7,19,6,6,8,10,14,19,24,26,23,19,8,"E",0.25,"-",0.56,"D",0.23,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE12!I10","v":0}]
[null,9,9,"W","L","H",7,0,0,0,0,2,8,0,0,"b","b","b","b",88,4,10,30,28,24,22,20,15,10,6,3,1,9,"W",0.23,"-",0.41,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE12!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,7,9,0,0,"b","b","b","b",91,3,6,40,33,19,14,10,7,4,2,1,0,10,"V",0.13,"-",0.3,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE12!I12","v":0}]
[null,11,11,"Q","L","H",8,0,59,0,30,2,9,0,0,"b","e","b","i",93,1,5,16,16,17,21,23,24,20,14,8,4,11,"Q",0.1,"-",0.27,"-",0.18,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE12!I13","v":0}]
[null,12,12,"A","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",92,1,5,23,22,21,22,21,19,15,10,5,2,12,"A",0.12,"-",0.26,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE12!I14","v":0}]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,46,35,16,9,6,4,2,1,0,0,13,"V",0.12,"-",0.23,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE12!I15","v":0},{"$nulls":12},"2. Solvent Accessibility: 229 residues (8%) are predicted to have changed its classification (according to Pbie or Pbe, with b=burried, i=intermediate, e=exposed). All predicted changes of solvent accessibility have very low (RI_A = 0-1) or low (RI_A = 2-3) reliability. NF1delE12's overall solvent accessibility is probably not reduced that much further, aside from the lost solvent accessibility attributed to the deleted exon. "]
[null,14,14,"V","L","H",9,0,0,0,0,5,9,0,0,"b","b","b","b",95,1,3,35,30,21,17,13,10,6,4,2,1,14,"V",0.14,"-",0.31,"-",0.37,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE12!I16","v":0}]
[null,15,15,"S","L","H",8,0,39,0,30,3,9,0,0,"b","e","b","i",90,2,7,12,12,14,18,21,24,22,18,11,7,15,"S",0.14,"-",0.4,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE12!I17","v":15}]
[null,16,16,"R","L","H",7,0,29,0,12,3,8,0,0,"b","b","b","i",89,2,10,15,18,23,26,26,22,16,9,4,2,16,"R",0.14,"-",0.37,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE12!I18","v":0}]
[null,17,17,"F","L","H",7,0,0,0,0,8,8,0,1,"b","b","b","b",90,2,11,41,33,21,14,10,7,4,2,1,1,17,"F",0.2,"-",0.41,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE12!I19","v":0}]
[null,18,18,"D","L","H",7,0,19,0,12,0,8,0,1,"b","b","b","i",87,3,13,19,19,19,20,20,20,19,16,12,9,18,"D",0.24,"-",0.6,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE12!I20","v":49}]
[null,19,19,"E","L","H",4,0,108,0,56,4,6,0,2,"b","e","b","e",71,3,29,5,6,7,9,12,16,22,26,26,25,19,"E",0.29,"-",0.59,"D",0.55,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE12!I21","v":31}]
[null,20,20,"Q","L","H",0,0,59,0,30,3,5,0,4,"b","e","b","i",53,5,45,7,9,13,19,23,26,25,21,15,10,20,"Q",0.31,"-",0.62,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE12!I22","v":0}]
[null,21,21,"L","L","L",6,0,0,0,0,0,1,0,8,"b","b","b","b",14,6,81,27,27,26,24,20,14,9,5,3,2,21,"L",0.35,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE12!I23","v":3}]
[null,22,22,"P","L","L",6,0,76,0,56,2,1,0,8,"b","e","b","e",14,6,80,12,11,11,13,16,21,24,25,22,19,22,"P",0.39,"-",0.57,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE12!I24","v":0}]
[null,23,23,"I","L","L",5,0,20,0,12,2,1,1,6,"b","b","b","i",19,14,71,17,19,22,24,21,18,14,12,12,11,23,"I",0.38,"-",0.55,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE12!I25","v":0},{"$nulls":12},"3. Disorder: 35 residues, predicted to be disordered in the full length protein are predicted to not be disordered in the protein produced by NF1delE12, while 5 residues are predicted to be disordered in the latter but not in neurofibromin. Most of these difference are in isolated single or pairs of residues, instead of longer sequences, with the exception of 19 residues in a 19 residue long sequence starting with the first residue after the deleted exon (some of which have medium prediction reliability), at position 465 in NF1fl, and another region of 11 residues, starting at position 849 in the CSRD of NF1fl, harboring 7 changes - but all these predictions have very low reliability. "]
[null,24,24,"K","L","L",4,0,114,0,56,3,1,1,6,"b","e","b","e",20,15,68,4,5,6,9,13,18,23,26,26,25,24,"K",0.39,"-",0.57,"D",0.57,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE12!I26","v":0}]
[null,25,25,"T","L","L",6,0,127,0,90,1,1,1,7,"b","e","b","e",14,11,75,9,9,9,11,14,17,21,23,26,27,25,"T",0.4,"-",0.57,"D",0.5,"-",0.384,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE12!I27","v":-25}]
[null,26,26,"G","L","L",7,0,10,0,12,0,0,1,7,"b","b","b","i",10,11,81,19,19,20,21,20,19,18,16,15,14,26,"G",0.4,"-",0.5,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE12!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,0,8,"b","e","b","e",11,9,80,11,11,13,16,18,20,22,22,22,21,27,"Q",0.43,"-",0.59,"D",0.76,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE12!I29","v":0}]
[null,28,28,"Q","L","L",4,0,110,0,56,1,2,1,6,"b","e","b","e",21,15,64,10,11,13,16,18,20,21,22,21,20,28,"Q",0.49,"-",0.64,"D",0.77,"D",0.51,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE12!I30","v":-27}]
[null,29,29,"N","L","L",3,0,65,0,42,0,2,1,6,"b","e","b","e",26,16,63,12,12,13,16,18,20,21,21,20,19,29,"N",0.4,"-",0.59,"D",0.66,"D",0.52,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE12!I31","v":0}]
[null,30,30,"T","L","L",3,0,28,0,20,0,2,1,5,"b","e","b","i",30,15,60,15,15,16,18,20,20,19,17,15,13,30,"T",0.39,"-",0.56,"D",0.66,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE12!I32","v":0}]
[null,31,31,"H","L","L",1,0,55,0,30,0,3,1,5,"b","e","b","i",36,14,54,11,12,13,16,19,21,21,20,18,16,31,"H",0.37,"-",0.58,"D",0.76,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE12!I33","v":22}]
[null,32,32,"T","L","L",1,0,42,0,30,0,3,1,4,"b","e","b","i",41,12,52,12,12,13,16,18,20,20,20,19,18,32,"T",0.3,"-",0.58,"D",0.7,"D",0.48,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE12!I34","v":17}]
[null,33,33,"K","L","H",0,0,86,0,42,1,4,1,4,"b","e","b","e",50,12,44,8,9,11,14,17,20,22,22,20,17,33,"K",0.36,"-",0.46,"-",0.68,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE12!I35","v":0},{"$nulls":12},"4. Protein Binding: Deletion of E12 leads to 11 newly predicted protein binding sites (CSRD: two), while 11 potential binding sites, predicted in full length NF1, are now predicted to be lost in the protein NF1delE12 (CSRD: two; GRD: one; Sec14&PH: one) - in addition to those in the deleted exon.  "]
[null,34,34,"V","L","H",1,0,42,0,30,1,5,1,3,"b","e","b","i",55,11,36,15,15,16,19,20,21,20,18,15,12,34,"V",0.28,"-",0.55,"D",0.79,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE12!I36","v":-14}]
[null,35,35,"S","L","H",2,0,0,0,0,0,5,0,3,"b","b","b","b",59,9,34,19,18,17,18,19,19,19,17,14,11,35,"S",0.24,"-",0.51,"D",0.86,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE12!I37","v":39}]
[null,36,36,"T","L","H",3,0,28,0,20,0,6,0,2,"b","e","b","i",66,7,28,19,19,19,20,21,21,19,15,11,9,36,"T",0.2,"-",0.55,"D",0.77,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE12!I38","v":0}]
[null,37,37,"E","L","H",5,0,108,0,56,3,7,0,2,"b","e","b","e",73,7,22,5,5,7,10,14,18,23,26,25,23,37,"E",0.15,"-",0.59,"D",0.62,"D",0.394,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE12!I39","v":0}]
[null,38,38,"H","L","H",4,0,36,0,20,1,6,0,2,"b","e","b","i",70,8,24,17,17,18,20,22,22,20,16,12,9,38,"H",0.14,"-",0.51,"D",0.35,"-",0.3,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE12!I40","v":0}]
[null,39,39,"N","L","H",4,0,0,0,0,4,6,0,2,"b","b","b","b",69,6,28,31,26,20,17,15,12,10,8,6,4,39,"N",0.13,"-",0.4,"-",0.47,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE12!I41","v":0}]
[null,40,40,"K","L","H",6,0,61,0,30,3,7,0,1,"b","e","b","i",80,5,17,12,12,14,18,22,24,23,19,14,10,40,"K",0.16,"-",0.43,"-",0.33,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G42-delE12!I42","v":0}]
[null,41,41,"E","L","H",6,0,81,0,42,1,8,0,1,"b","e","b","e",83,6,14,12,13,14,17,19,22,23,22,18,15,41,"E",0.17,"-",0.46,"-",0.36,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G43-delE12!I43","v":0}]
[null,42,42,"C","L","H",6,0,0,0,0,3,7,1,1,"b","b","b","b",78,13,13,30,27,22,19,17,13,9,6,3,2,42,"C",0.21,"-",0.28,"-",0.41,"-",0.28,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G44-delE12!I44","v":0}]
[null,43,43,"L","L","H",5,0,0,0,0,8,6,1,1,"b","b","b","b",74,19,13,42,34,20,13,9,7,5,3,2,1,43,"L",0.2,"-",0.26,"-",0.32,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G45-delE12!I45","v":0}]
[null,44,44,"I","L","H",4,0,0,0,0,3,6,2,1,"b","b","b","b",68,21,16,31,28,22,19,15,12,8,5,3,2,44,"I",0.11,"-",0.39,"-",0.4,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G46-delE12!I46","v":0}]
[null,45,45,"N","L","H",5,0,31,0,20,1,6,1,1,"b","e","b","i",71,14,21,17,17,17,20,22,22,20,16,11,8,45,"N",0.08,"-",0.36,"-",0.21,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G47-delE12!I47","v":16}]
[null,46,46,"I","L","H",3,0,0,0,0,5,6,1,2,"b","b","b","b",65,12,27,36,31,23,17,13,10,6,4,2,1,46,"I",0.08,"-",0.41,"-",0.2,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G48-delE12!I48","v":0}]
[null,47,47,"S","L","H",1,0,0,0,0,6,5,0,3,"b","b","b","b",56,8,39,36,30,21,16,13,10,7,5,4,3,47,"S",0.06,"-",0.43,"-",0.19,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G49-delE12!I49","v":0}]
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[null,2783,2739,"T","L","L",6,0,17,0,12,0,1,1,7,"b","b","b","i",12,13,79,20,20,20,21,21,20,18,16,14,12,2739,"T",0.61,"D",0.47,"D",0.54,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2785-delE12!I2785","v":-17}]
[null,2784,2740,"T","L","L",5,0,0,0,0,0,1,1,6,"b","b","b","b",17,15,71,20,20,20,20,20,19,17,14,12,11,2740,"T",0.66,"D",0.49,"D",0.44,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2786-delE12!I2786","v":0}]
[null,2785,2741,"G","L","L",5,0,35,0,42,0,1,1,6,"b","e","b","e",20,13,72,14,14,14,17,18,20,21,20,20,19,2741,"G",0.67,"D",0.49,"D",0.6,"D",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2787-delE12!I2787","v":-10}]
[null,2786,2742,"H","L","L",4,0,55,0,30,1,2,1,6,"b","e","b","i",24,18,66,12,13,16,19,22,23,22,20,18,16,2742,"H",0.69,"D",0.51,"D",0.57,"-",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2788-delE12!I2788","v":0}]
[null,2787,2743,"C","L","L",5,0,16,0,12,1,1,1,6,"b","b","b","i",19,16,70,18,19,20,22,21,19,16,13,12,11,2743,"C",0.69,"D",0.47,"D",0.57,"-",0.576,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2789-delE12!I2789","v":11}]
[null,2788,2744,"N","L","L",6,0,141,0,90,1,1,1,7,"b","e","b","e",14,13,75,9,9,10,13,16,18,21,22,25,26,2744,"N",0.67,"D",0.43,"-",0.55,"-",0.592,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2790-delE12!I2790","v":0}]
[null,2789,2745,"S","L","L",6,0,93,0,72,0,1,1,7,"b","e","b","e",14,13,77,13,14,14,17,18,20,20,20,21,21,2745,"S",0.59,"D",0.48,"D",0.52,"-",0.606,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2791-delE12!I2791","v":0}]
[null,2790,2746,"G","L","L",5,0,25,0,30,1,1,1,6,"b","e","b","i",15,17,73,13,14,16,19,21,22,21,19,17,16,2746,"G",0.42,"-",0.4,"-",0.57,"-",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2792-delE12!I2792","v":0}]
[null,2791,2747,"R","L","L",4,0,49,0,20,1,1,2,6,"b","e","b","i",15,24,67,15,16,17,20,22,22,21,18,15,13,2747,"R",0.45,"-",0.48,"D",0.59,"D",0.602,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2793-delE12!I2793","v":0}]
[null,2792,2748,"T","L","L",4,0,0,0,0,0,1,2,6,"b","b","b","b",16,24,64,21,21,20,21,20,19,17,15,12,10,2748,"T",0.53,"D",0.46,"-",0.74,"D",0.622,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2794-delE12!I2794","v":28}]
[null,2793,2749,"R","L","L",3,0,29,0,12,0,1,2,5,"b","b","b","i",19,26,59,21,21,21,22,21,19,16,12,9,8,2749,"R",0.55,"D",0.39,"-",0.76,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2795-delE12!I2795","v":0}]
[null,2794,2750,"H","L","L",3,0,0,0,0,0,1,2,5,"b","b","b","b",17,25,62,23,22,21,21,20,18,15,12,9,8,2750,"H",0.59,"D",0.41,"-",0.66,"D",0.622,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2796-delE12!I2796","v":0}]
[null,2795,2751,"G","L","L",4,0,10,0,12,0,2,1,5,"b","b","b","i",23,20,64,21,21,21,22,21,19,17,14,12,11,2751,"G",0.6,"D",0.46,"-",0.73,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2797-delE12!I2797","v":0}]
[null,2796,2752,"S","L","L",3,0,0,0,0,0,2,1,5,"b","b","b","b",30,19,62,23,22,20,20,20,19,17,15,14,13,2752,"S",0.66,"D",0.41,"-",0.83,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2798-delE12!I2798","v":0}]
[null,2797,2753,"A","L","L",1,0,0,0,0,1,3,1,4,"b","b","b","b",44,15,54,24,22,20,20,19,18,15,13,13,12,2753,"A",0.73,"D",0.39,"-",0.87,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2799-delE12!I2799","v":0}]
[null,2798,2754,"S","L","L",1,0,39,0,30,0,3,1,4,"b","e","b","i",42,15,55,14,14,15,18,20,21,21,20,20,19,2754,"S",0.68,"D",0.52,"D",0.87,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2800-delE12!I2800","v":0}]
[null,2799,2755,"Q","L","L",1,0,83,0,42,1,3,1,5,"b","e","b","e",41,15,57,9,10,12,16,20,22,23,22,21,19,2755,"Q",0.69,"D",0.64,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE12!I2801","v":0}]
[null,2800,2756,"V","L","L",3,0,17,0,12,1,2,1,5,"b","b","b","i",28,16,63,18,19,20,22,21,19,16,14,12,12,2756,"V",0.68,"D",0.66,"D",0.91,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE12!I2802","v":11}]
[null,2801,2757,"Q","L","L",4,0,83,0,42,1,1,1,6,"b","e","b","e",21,18,68,11,12,14,17,20,21,22,21,19,18,2757,"Q",0.68,"D",0.69,"D",0.88,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE12!I2803","v":0}]
[null,2802,2758,"K","L","L",5,0,147,0,72,2,1,1,7,"b","e","b","e",19,12,75,7,7,9,13,16,20,23,25,27,27,2758,"K",0.67,"D",0.72,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE12!I2804","v":0}]
[null,2803,2759,"Q","L","L",6,0,142,0,72,2,1,1,7,"b","e","b","e",16,12,76,6,7,9,13,16,19,22,24,26,26,2759,"Q",0.59,"D",0.68,"D",0.79,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE12!I2805","v":-32}]
[null,2804,2760,"R","L","L",5,0,104,0,42,0,1,1,7,"b","e","b","e",17,13,74,10,11,13,16,19,21,22,21,21,20,2760,"R",0.56,"D",0.68,"D",0.87,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE12!I2806","v":34}]
[null,2805,2761,"S","L","L",5,0,39,0,30,1,1,1,7,"b","e","b","i",17,14,74,13,14,16,19,21,22,21,19,18,16,2761,"S",0.57,"D",0.64,"D",0.93,"D",0.663,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE12!I2807","v":-13}]
[null,2806,2762,"A","L","L",4,0,31,0,30,0,2,1,6,"b","e","b","i",22,15,68,13,14,15,18,19,21,21,21,21,20,2762,"A",0.58,"D",0.59,"D",0.92,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE12!I2808","v":0}]
[null,2807,2763,"G","L","L",4,0,10,0,12,0,2,1,6,"b","b","b","i",24,15,66,19,19,19,21,21,21,19,18,16,15,2763,"G",0.55,"D",0.51,"D",0.85,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE12!I2809","v":15}]
[null,2808,2764,"S","L","L",3,0,0,0,0,0,2,1,5,"b","b","b","b",29,16,63,21,20,19,20,20,20,19,18,16,15,2764,"S",0.56,"D",0.53,"D",0.73,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE12!I2810","v":0}]
[null,2809,2765,"F","L","L",2,0,0,0,0,0,2,2,4,"b","b","b","b",32,23,54,25,24,23,23,20,17,13,10,9,8,2765,"F",0.71,"D",0.64,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE12!I2811","v":0}]
[null,2810,2766,"K","L","L",2,0,114,0,56,2,2,1,5,"b","e","b","e",30,19,59,7,8,9,12,16,20,23,25,24,22,2766,"K",0.64,"D",0.64,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE12!I2812","v":-28}]
[null,2811,2767,"R","L","L",1,0,74,0,30,1,3,1,5,"b","e","b","i",39,15,55,8,9,13,18,21,23,23,21,18,16,2767,"R",0.71,"D",0.64,"D",0.86,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE12!I2813","v":0}]
[null,2812,2768,"N","L","L",0,0,113,0,72,2,4,1,4,"b","e","b","e",46,11,53,5,6,8,11,15,18,21,24,25,25,2768,"N",0.37,"-",0.76,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE12!I2814","v":0}]
[null,2813,2769,"S","L","H",1,0,93,0,72,1,5,1,3,"b","e","b","e",56,12,43,8,9,11,14,17,19,22,23,25,24,2769,"S",0.26,"-",0.7,"D",0.8,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE12!I2815","v":-21}]
[null,2814,2770,"I","L","H",1,0,33,0,20,0,5,1,3,"b","e","b","i",56,11,43,15,15,16,18,20,20,20,19,18,17,2770,"I",0.4,"-",0.62,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE12!I2816","v":17}]
[null,2815,2771,"K","L","H",0,0,147,0,72,2,4,1,4,"b","e","b","e",48,15,48,4,4,7,11,15,19,23,26,27,26,2771,"K",0.32,"-",0.74,"D",0.81,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE12!I2817","v":0}]
[null,2816,2772,"K","L","L",2,0,184,0,90,2,2,2,5,"b","e","b","e",32,23,56,3,4,6,9,13,17,21,25,28,29,2772,"K",0.4,"-",0.82,"D",0.77,"D",0.582,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE12!I2818","v":-37}]
[null,2817,2773,"I","L","L",4,0,121,0,72,0,1,1,6,"b","e","b","e",20,21,65,7,8,11,14,17,18,19,18,20,20,2773,"I",0.33,"-",0.8,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE12!I2819","v":-101}]
[null,2818,2774,"V","L","L",8,0,127,0,90,4,0,0,9,"b","e","b","e",3,7,91,7,6,7,8,10,12,14,17,26,30,2774,"V",0.37,"-",0.85,"D",0.74,"D",0.545,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE12!I2820","v":0}]
[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":2916}]
[{"$nulls":55},{"$f":"SUM(BD2:BD2820)-SUM(BD423:BD466)","v":1613}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},44,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":88},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":74},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":196},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":40},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":229},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.03172314347512617,"d":"3%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.0825522710886806,"d":"8%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":121},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":78},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":27},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":3},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":56},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":16},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":13},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":5},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":11}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":35},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":11}]

{"sheet":"delE17","index":3,"n_rows":2864,"n_cols":69,"rows_kept":2250,"cut":true,"merged":[[0,2,0,43],[7,68,10,118],[14,68,21,118],[24,68,31,118],[35,68,38,118],[617,2,668,43],[1175,0,1572,0],[2822,54,2834,55]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
[null,null,"delE17"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE17)"]
[null,1,1,"M","L","L",9,0,169,0,90,4,0,0,9,"b","e","b","e",1,1,96,8,8,8,9,11,13,14,16,24,28,1,"M",0.33,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE17!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",9,7,85,6,6,7,10,13,16,19,21,26,28,2,"A",0.21,"-",0.85,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE17!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",6,0,76,0,72,1,1,0,8,"b","e","b","e",13,7,82,7,7,9,13,16,20,22,23,25,24,3,"A",0.1,"-",0.83,"D",0.36,"-",0.556,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE17!I5","v":0},{"$nulls":12},"SUMMARY: "]
[null,4,4,"H","L","L",5,0,132,0,72,2,2,1,6,"b","e","b","e",21,11,73,6,6,8,12,15,18,22,24,27,27,4,"H",0.12,"-",0.84,"D",0.29,"-",0.505,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE17!I6","v":0}]
[null,5,5,"R","L","L",5,0,104,0,42,3,1,0,7,"b","e","b","e",17,10,76,6,7,10,15,20,25,27,24,20,16,5,"R",0.1,"-",0.69,"D",0.34,"-",0.449,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE17!I7","v":0}]
[null,6,6,"P","L","L",1,0,40,0,30,1,3,0,5,"b","e","b","i",40,6,58,16,16,17,19,21,22,21,18,15,13,6,"P",0.09,"-",0.62,"D",0.34,"-",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE17!I8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (2%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of neurofibromin. This is the lowest value calculated over all studied proteins with deleted exons. All predicted changes in secondary structure have very low (RI_S = 0-1) or low reliability (RI_S = 2-3). "]
[null,7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",65,5,35,14,14,16,19,20,20,19,16,13,10,7,"V",0.22,"-",0.6,"D",0.28,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE17!I9","v":0}]
[null,8,8,"E","L","H",6,0,108,0,56,2,7,0,1,"b","e","b","e",78,7,18,7,8,9,12,16,20,24,25,21,18,8,"E",0.26,"-",0.54,"D",0.23,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE17!I10","v":0}]
[null,9,9,"W","L","H",8,0,0,0,0,3,8,0,0,"b","b","b","b",89,4,8,31,28,24,21,18,14,9,5,2,1,9,"W",0.22,"-",0.39,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE17!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,7,9,0,0,"b","b","b","b",91,3,7,40,33,19,14,10,7,4,2,1,0,10,"V",0.12,"-",0.3,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE17!I12","v":0}]
[null,11,11,"Q","L","H",8,0,39,0,20,1,9,0,0,"b","e","b","i",93,1,5,17,17,17,21,23,23,20,14,7,3,11,"Q",0.1,"-",0.26,"-",0.18,"-",0.33,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE17!I13","v":20}]
[null,12,12,"A","L","H",8,0,0,0,0,1,9,0,0,"b","b","b","b",92,1,5,25,23,21,21,20,18,14,10,5,2,12,"A",0.13,"-",0.26,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE17!I14","v":0}]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,46,35,16,9,6,3,2,1,0,0,13,"V",0.12,"-",0.23,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE17!I15","v":0},{"$nulls":12},"2. Solvent Accessibility: 193 residues (7%) are predicted to have changed their solvent accessibility classification (according to Pbie or Pbe, with b=burried, i=intermediate, e=exposed). This is the smallest percentage calculated for all studied exon deletions. All predicted changes of solvent accessibility have very low (RI_A = 0-1) or low reliability (RI_A = 2-3).NF1delE17's net solvent accessibility appears to be very similar to that of neurofibromin, if we disregard the lost solvent accessibility due to the deleted exon."]
[null,14,14,"V","L","H",9,0,0,0,0,5,9,0,0,"b","b","b","b",95,1,4,35,30,20,16,12,9,6,4,2,1,14,"V",0.13,"-",0.32,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE17!I16","v":0}]
[null,15,15,"S","L","H",8,0,54,0,42,3,9,0,0,"b","e","b","e",91,1,8,8,9,11,14,18,22,24,21,14,9,15,"S",0.15,"-",0.41,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE17!I17","v":0}]
[null,16,16,"R","L","H",7,0,29,0,12,2,8,0,1,"b","b","b","i",89,2,11,16,18,22,25,25,22,16,9,4,2,16,"R",0.14,"-",0.39,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE17!I18","v":0}]
[null,17,17,"F","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",90,1,9,42,34,21,14,10,6,4,2,1,1,17,"F",0.21,"-",0.41,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE17!I19","v":0}]
[null,18,18,"D","L","H",7,0,68,0,42,2,8,0,1,"b","e","b","e",88,2,11,12,12,14,17,20,23,24,21,16,11,18,"D",0.23,"-",0.61,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE17!I20","v":0}]
[null,19,19,"E","L","H",4,0,139,0,72,3,7,0,2,"b","e","b","e",73,3,28,4,5,6,9,12,16,21,26,27,27,19,"E",0.28,"-",0.59,"D",0.55,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE17!I21","v":0}]
[null,20,20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",57,4,42,8,10,14,19,23,26,25,20,14,10,20,"Q",0.27,"-",0.6,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE17!I22","v":0}]
[null,21,21,"L","L","L",6,0,3,0,2,2,1,0,8,"b","b","b","b",15,4,81,28,29,28,25,20,14,8,5,3,2,21,"L",0.31,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE17!I23","v":0}]
[null,22,22,"P","L","L",7,0,76,0,56,2,1,0,8,"b","e","b","e",11,6,83,12,12,11,13,16,20,24,25,22,19,22,"P",0.37,"-",0.58,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE17!I24","v":0}]
[null,23,23,"I","L","L",5,0,20,0,12,2,1,1,6,"b","b","b","i",18,14,70,17,19,23,24,22,18,14,12,12,11,23,"I",0.35,"-",0.54,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE17!I25","v":0},{"$nulls":12},"3. Disorder: 17 residues, predicted to be disordered in the full length protein are predicted to not be disordered in the protein produced by NF1delE17, while 1 residue is predicted to be disordered in the latter but not in neurofibromin. Differences are in isolated single residues or pairs of residues, instead of longer sequences. The only more \"concentrated\" regions are sequences of 6 and 7 residues length, each with 4 residues predicted to no longer be disordered, at positions 29-34 and 803-809 in NF1fl, respectively. All predictions have the lowest reliability score."]
[null,24,24,"K","L","L",4,0,147,0,72,2,1,1,6,"b","e","b","e",19,16,68,4,5,7,10,14,18,23,25,26,25,24,"K",0.38,"-",0.57,"D",0.57,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE17!I26","v":-33}]
[null,25,25,"T","L","L",6,0,127,0,90,2,1,1,7,"b","e","b","e",14,12,75,9,9,9,11,14,17,20,23,26,27,25,"T",0.39,"-",0.56,"D",0.5,"-",0.384,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE17!I27","v":-25}]
[null,26,26,"G","L","L",6,0,10,0,12,0,0,1,7,"b","b","b","i",10,11,80,20,20,20,21,20,19,18,16,15,14,26,"G",0.37,"-",0.49,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE17!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,1,7,"b","e","b","e",13,12,75,12,12,14,17,19,21,22,22,21,20,27,"Q",0.42,"-",0.58,"D",0.76,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE17!I29","v":0}]
[null,28,28,"Q","L","L",3,0,110,0,56,1,2,1,6,"b","e","b","e",22,18,61,10,11,13,16,18,20,21,22,21,20,28,"Q",0.48,"-",0.62,"D",0.77,"D",0.51,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE17!I30","v":-27}]
[null,29,29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",26,18,60,12,12,13,16,18,20,21,21,20,19,29,"N",0.38,"-",0.61,"D",0.66,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE17!I31","v":0}]
[null,30,30,"T","L","L",2,0,28,0,20,0,2,1,5,"b","e","b","i",29,17,57,16,16,17,19,20,20,19,17,14,12,30,"T",0.37,"-",0.57,"D",0.66,"D",0.48,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE17!I32","v":0}]
[null,31,31,"H","L","L",1,0,77,0,42,1,3,1,5,"b","e","b","e",35,16,53,11,12,13,16,18,20,21,20,18,16,31,"H",0.35,"-",0.59,"D",0.76,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE17!I33","v":0}]
[null,32,32,"T","L","L",1,0,59,0,42,0,3,1,4,"b","e","b","e",40,14,51,12,12,13,16,18,19,20,20,19,18,32,"T",0.26,"-",0.58,"D",0.7,"D",0.48,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE17!I34","v":0}]
[null,33,33,"K","L","H",0,0,86,0,42,1,4,1,4,"b","e","b","e",46,13,46,8,9,10,13,16,20,22,22,20,18,33,"K",0.31,"-",0.45,"-",0.68,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE17!I35","v":0}]
[null,34,34,"V","L","H",1,0,42,0,30,1,5,1,3,"b","e","b","i",54,11,38,14,15,16,18,20,21,20,19,16,14,34,"V",0.25,"-",0.56,"D",0.79,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE17!I36","v":-14},{"$nulls":12},"4. Protein Binding: Deletion of E17 (part of the CSRD) leads to 10 newly predicted potential protein binding sites (Tubulin binding domain: one; GRD: two; Sec14&PH: one), while 9 potential binding sites, predicted in full length NF1, are now predicted to be lost in the protein NF1delE17 (CSRD: one; GRD: one; Sec14&PH: one) - in addition to those in the deleted exon.  "]
[null,35,35,"S","L","H",2,0,26,0,20,0,5,0,3,"b","e","b","i",60,10,33,18,17,16,18,19,19,19,17,14,11,35,"S",0.21,"-",0.49,"D",0.86,"D",0.424,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE17!I37","v":13}]
[null,36,36,"T","L","H",3,0,28,0,20,0,6,0,2,"b","e","b","i",66,7,28,19,19,19,20,21,21,19,15,11,8,36,"T",0.18,"-",0.53,"D",0.77,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE17!I38","v":0}]
[null,37,37,"E","L","H",5,0,108,0,56,3,7,0,1,"b","e","b","e",75,7,19,5,6,7,10,14,18,23,25,24,22,37,"E",0.14,"-",0.56,"D",0.62,"D",0.404,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE17!I39","v":0}]
[null,38,38,"H","L","H",5,0,36,0,20,1,7,0,2,"b","e","b","i",74,7,21,18,17,18,20,22,22,20,15,11,8,38,"H",0.13,"-",0.46,"-",0.35,"-",0.3,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE17!I40","v":0}]
[null,39,39,"N","L","H",5,0,0,0,0,4,7,0,2,"b","b","b","b",74,5,22,32,27,20,16,14,12,10,7,5,4,39,"N",0.13,"-",0.36,"-",0.47,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE17!I41","v":0}]
[null,40,40,"K","L","H",7,0,61,0,30,3,8,0,1,"b","e","b","i",85,3,14,12,13,15,19,23,25,23,19,13,9,40,"K",0.14,"-",0.41,"-",0.33,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G42-delE17!I42","v":0}]
[null,41,41,"E","L","H",7,0,81,0,42,2,8,0,1,"b","e","b","e",85,4,12,12,13,14,16,19,22,23,22,18,14,41,"E",0.17,"-",0.46,"-",0.36,"-",0.31,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G43-delE17!I43","v":0}]
[null,42,42,"C","L","H",6,0,0,0,0,3,7,0,1,"b","b","b","b",81,9,12,30,27,22,19,17,13,9,6,3,2,42,"C",0.2,"-",0.29,"-",0.41,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G44-delE17!I44","v":0}]
[null,43,43,"L","L","H",6,0,0,0,0,8,7,1,1,"b","b","b","b",78,15,13,42,34,20,13,10,7,5,3,2,1,43,"L",0.19,"-",0.28,"-",0.32,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G45-delE17!I45","v":0}]
[null,44,44,"I","L","H",5,0,0,0,0,3,6,1,1,"b","b","b","b",71,17,16,30,27,22,19,16,12,9,6,4,2,44,"I",0.11,"-",0.4,"-",0.4,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G46-delE17!I46","v":0}]
[null,45,45,"N","L","H",4,0,47,0,30,1,6,1,2,"b","e","b","i",69,14,22,15,15,16,19,21,22,20,17,12,9,45,"N",0.08,"-",0.39,"-",0.21,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G47-delE17!I47","v":0}]
[null,46,46,"I","L","H",3,0,0,0,0,5,6,0,2,"b","b","b","b",65,10,28,35,31,23,18,14,10,7,4,2,1,46,"I",0.08,"-",0.41,"-",0.2,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G48-delE17!I48","v":0}]
[null,47,47,"S","L","H",1,0,0,0,0,6,5,0,3,"b","b","b","b",54,8,40,36,30,21,16,14,10,8,5,4,3,47,"S",0.06,"-",0.44,"-",0.19,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G49-delE17!I49","v":0}]
[null,48,48,"K","L","H",3,0,86,0,42,1,6,0,3,"b","e","b","e",65,4,33,13,13,13,15,18,21,22,22,20,18,48,"K",0.07,"-",0.57,"D",0.2,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G50-delE17!I50","v":0}]
[null,49,49,"Y","L","H",1,0,44,0,20,1,5,0,3,"b","e","b","i",58,4,40,18,18,20,22,23,22,18,14,10,8,49,"Y",0.09,"-",0.49,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G51-delE17!I51","v":-18}]
[null,50,50,"K","L","H",2,0,41,0,20,0,5,0,3,"b","e","b","i",62,6,36,19,18,18,20,21,21,18,14,10,7,50,"K",0.1,"-",0.47,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G52-delE17!I52","v":0}]
[null,51,51,"F","L","H",5,0,0,0,0,4,7,0,2,"b","b","b","b",77,4,21,34,30,22,18,14,11,7,5,3,2,51,"F",0.12,"-",0.34,"-",0.26,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G53-delE17!I53","v":0}]
[null,52,52,"S","L","H",7,0,0,0,0,1,8,0,1,"b","b","b","b",86,3,13,25,23,19,19,18,16,13,10,7,5,52,"S",0.1,"-",0.32,"-",0.18,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G54-delE17!I54","v":0}]
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[null,2796,2744,"S","L","L",3,0,0,0,0,0,2,1,5,"b","b","b","b",28,17,67,22,21,19,20,20,19,18,16,15,13,2744,"S",0.66,"D",0.46,"-",0.83,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2798-delE17!I2798","v":0}]
[null,2797,2745,"A","L","L",1,0,0,0,0,0,3,1,5,"b","b","b","b",42,13,58,23,22,20,21,20,19,17,15,14,13,2745,"A",0.72,"D",0.42,"-",0.87,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2799-delE17!I2799","v":0}]
[null,2798,2746,"S","L","L",1,0,54,0,42,0,3,1,5,"b","e","b","e",42,12,56,13,13,14,17,19,20,21,21,21,21,2746,"S",0.69,"D",0.57,"D",0.87,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2800-delE17!I2800","v":-15}]
[null,2799,2747,"Q","L","L",2,0,83,0,42,1,3,1,5,"b","e","b","e",37,14,58,8,10,12,16,19,22,23,22,21,19,2747,"Q",0.67,"D",0.65,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE17!I2801","v":0}]
[null,2800,2748,"V","L","L",2,0,28,0,20,1,2,1,5,"b","e","b","i",32,19,59,15,15,16,19,21,21,19,17,16,15,2748,"V",0.67,"D",0.64,"D",0.91,"D",0.633,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE17!I2802","v":0}]
[null,2801,2749,"Q","L","L",4,0,59,0,30,0,2,1,6,"b","e","b","i",22,20,66,12,12,14,17,20,21,21,20,19,17,2749,"Q",0.68,"D",0.69,"D",0.88,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE17!I2803","v":24}]
[null,2802,2750,"K","L","L",5,0,147,0,72,2,1,1,6,"b","e","b","e",18,17,72,7,8,9,12,15,19,22,25,26,26,2750,"K",0.66,"D",0.67,"D",0.9,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE17!I2804","v":0}]
[null,2803,2751,"Q","L","L",5,0,83,0,42,0,1,1,7,"b","e","b","e",16,15,75,7,8,12,16,19,21,22,22,22,21,2751,"Q",0.58,"D",0.63,"D",0.79,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE17!I2805","v":27}]
[null,2804,2752,"R","L","L",5,0,104,0,42,0,1,1,6,"b","e","b","e",18,14,74,9,10,12,15,18,21,23,23,23,22,2752,"R",0.58,"D",0.64,"D",0.87,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE17!I2806","v":34}]
[null,2805,2753,"S","L","L",5,0,26,0,20,1,1,1,6,"b","e","b","i",20,15,71,16,17,18,20,21,20,19,17,16,16,2753,"S",0.6,"D",0.58,"D",0.93,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE17!I2807","v":0}]
[null,2806,2754,"A","L","L",3,0,44,0,42,0,2,1,6,"b","e","b","e",28,14,66,13,13,14,17,19,20,21,20,21,20,2754,"A",0.62,"D",0.59,"D",0.92,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE17!I2808","v":-13}]
[null,2807,2755,"G","L","L",4,0,25,0,30,0,2,1,6,"b","e","b","i",27,14,67,14,14,15,18,20,22,22,20,19,17,2755,"G",0.62,"D",0.52,"D",0.85,"D",0.663,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE17!I2809","v":0}]
[null,2808,2756,"S","L","L",3,0,0,0,0,0,2,1,5,"b","b","b","b",31,14,65,20,20,19,20,20,20,19,17,15,14,2756,"S",0.58,"D",0.53,"D",0.73,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE17!I2810","v":0}]
[null,2809,2757,"F","L","L",1,0,0,0,0,0,3,2,4,"b","b","b","b",34,23,52,25,25,23,23,20,16,12,9,9,8,2757,"F",0.68,"D",0.6,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE17!I2811","v":0}]
[null,2810,2758,"K","L","L",2,0,114,0,56,2,3,1,5,"b","e","b","e",33,20,54,6,7,8,12,16,21,24,25,23,21,2758,"K",0.62,"D",0.57,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE17!I2812","v":-28}]
[null,2811,2759,"R","L","L",0,0,74,0,30,1,3,1,4,"b","e","b","i",43,16,49,8,9,13,18,22,24,23,21,19,16,2759,"R",0.68,"D",0.63,"D",0.86,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE17!I2813","v":0}]
[null,2812,2760,"N","L","L",0,0,87,0,56,1,4,1,4,"b","e","b","e",46,13,51,8,9,11,15,18,20,21,22,22,21,2760,"N",0.34,"-",0.72,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE17!I2814","v":26}]
[null,2813,2761,"S","L","L",0,0,93,0,72,1,4,1,3,"b","e","b","e",54,16,45,8,9,11,15,18,20,22,23,24,23,2761,"S",0.27,"-",0.59,"D",0.8,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE17!I2815","v":-21}]
[null,2814,2762,"I","L","L",0,0,121,0,72,0,4,1,4,"b","e","b","e",50,17,48,11,12,13,15,17,19,20,21,22,21,2762,"I",0.41,"-",0.61,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE17!I2816","v":-71}]
[null,2815,2763,"K","L","L",1,0,147,0,72,3,3,1,4,"b","e","b","e",40,22,51,3,3,6,9,13,17,23,26,29,28,2763,"K",0.31,"-",0.66,"D",0.81,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE17!I2817","v":0}]
[null,2816,2764,"K","L","L",2,0,147,0,72,3,2,2,5,"b","e","b","e",26,29,56,4,5,7,10,14,18,22,25,28,28,2764,"K",0.36,"-",0.79,"D",0.77,"D",0.571,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE17!I2818","v":0}]
[null,2817,2765,"I","L","L",3,0,152,0,90,0,1,2,6,"b","e","b","e",14,27,62,9,10,12,15,18,19,18,18,19,20,2765,"I",0.36,"-",0.77,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE17!I2819","v":-132}]
[null,2818,2766,"V","L","L",8,0,127,0,90,5,0,0,8,"b","e","b","e",3,9,90,4,4,5,7,9,12,15,18,28,32,2766,"V",0.39,"-",0.83,"D",0.74,"D",0.535,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE17!I2820","v":0}]
[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":1220}]
[{"$nulls":55},{"$f":"SUM(BD2:BD2820)-SUM(BD618:BD669)","v":-143}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},52,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":54},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":71},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":158},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":40},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":193},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.019522776572668113,"d":"2%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.06977584960231381,"d":"7%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":104},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":66},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":16},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":7},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":48},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":4},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":1},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":10}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":17},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":9}]

{"sheet":"delE1819","index":4,"n_rows":2864,"n_cols":69,"rows_kept":2250,"cut":true,"merged":[[0,2,0,43],[7,68,11,118],[13,68,23,118],[25,68,30,118],[34,68,38,118],[669,2,776,43],[1175,0,1572,0],[2822,54,2834,55]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
[null,null,"delE1819"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE1819)"]
[null,1,1,"M","L","L",9,0,169,0,90,4,0,0,9,"b","e","b","e",1,1,96,8,8,8,10,11,13,14,16,24,28,1,"M",0.31,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE1819!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",9,8,85,7,7,8,11,14,17,19,20,25,26,2,"A",0.22,"-",0.85,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE1819!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",7,0,76,0,72,1,1,0,8,"b","e","b","e",12,8,82,8,8,9,13,16,19,22,23,24,24,3,"A",0.09,"-",0.83,"D",0.36,"-",0.556,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE1819!I5","v":0},{"$nulls":12},"SUMMARY: "]
[null,4,4,"H","L","L",5,0,132,0,72,1,1,1,7,"b","e","b","e",19,11,74,6,7,9,13,16,19,22,24,25,24,4,"H",0.11,"-",0.83,"D",0.29,"-",0.505,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE1819!I6","v":0}]
[null,5,5,"R","L","L",6,0,104,0,42,2,1,1,7,"b","e","b","e",16,11,76,8,9,11,16,20,23,25,24,21,18,5,"R",0.1,"-",0.69,"D",0.34,"-",0.449,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE1819!I7","v":0}]
[null,6,6,"P","L","L",2,0,40,0,30,2,3,0,5,"b","e","b","i",39,7,60,14,14,15,18,21,23,22,19,15,12,6,"P",0.08,"-",0.62,"D",0.34,"-",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE1819!I8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (3%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of neurofibromin. Almost all predicted changes in secondary structure have very low reliability (RI_S = 0-1), few have low reliability (RI_S = 2-3), four have a medium reliability (RI_S = 4-5), and only one has a high reliability (RI_S = 6); those with reliability RI_S=5 or 6 are all located in the CSRD. "]
[null,7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",67,4,32,14,15,17,20,21,20,18,15,12,10,7,"V",0.2,"-",0.57,"D",0.28,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE1819!I9","v":0}]
[null,8,8,"E","L","H",6,0,108,0,56,3,7,0,1,"b","e","b","e",78,7,18,6,7,8,11,15,19,24,26,22,19,8,"E",0.25,"-",0.54,"D",0.23,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE1819!I10","v":0}]
[null,9,9,"W","L","H",7,0,0,0,0,2,8,0,0,"b","b","b","b",88,4,10,30,27,23,22,19,15,10,6,3,1,9,"W",0.22,"-",0.4,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE1819!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",90,3,6,41,33,18,13,10,7,4,2,1,0,10,"V",0.13,"-",0.29,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE1819!I12","v":0}]
[null,11,11,"Q","L","H",8,0,39,0,20,2,9,0,0,"b","e","b","i",92,1,5,17,17,18,22,24,24,19,13,7,3,11,"Q",0.1,"-",0.26,"-",0.18,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE1819!I13","v":20}]
[null,12,12,"A","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",92,1,5,24,23,21,21,21,19,15,10,5,2,12,"A",0.13,"-",0.24,"-",0.25,"-",0.33,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE1819!I14","v":0},{"$nulls":12},"2. Solvent Accessibility: 244 residues (9%) are predicted to have changed their classification (according to Pbie/Pbe; b=burried, i=intermediate, e=exposed). Almost all predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-3); only one has medium reliability (RI_A = 4) and is located in the CSRD region - with a change from intermediate to burried. NF1delE18/E19's net solvent accessibility appears to be very similar to that of neurofibromin, if we disregard the lost solvent accessibility due to the deleted exon."]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,46,35,16,9,6,3,2,1,0,0,13,"V",0.11,"-",0.23,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE1819!I15","v":0}]
[null,14,14,"V","L","H",9,0,0,0,0,5,9,0,0,"b","b","b","b",95,1,3,35,30,20,16,12,9,6,4,2,1,14,"V",0.13,"-",0.31,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE1819!I16","v":0}]
[null,15,15,"S","L","H",8,0,54,0,42,3,9,0,0,"b","e","b","e",91,2,7,8,9,11,14,18,22,24,21,14,9,15,"S",0.14,"-",0.41,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE1819!I17","v":0}]
[null,16,16,"R","L","H",8,0,29,0,12,2,8,0,0,"b","b","b","i",90,2,9,16,18,22,25,25,22,16,9,4,2,16,"R",0.13,"-",0.38,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE1819!I18","v":0}]
[null,17,17,"F","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",90,1,9,42,34,21,14,10,6,4,2,1,0,17,"F",0.2,"-",0.41,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE1819!I19","v":0}]
[null,18,18,"D","L","H",7,0,68,0,42,1,8,0,1,"b","e","b","e",88,2,12,12,12,14,17,19,22,23,21,16,11,18,"D",0.23,"-",0.61,"D",0.44,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE1819!I20","v":0}]
[null,19,19,"E","L","H",4,0,139,0,72,3,6,0,2,"b","e","b","e",71,3,29,4,4,6,9,12,16,21,26,27,27,19,"E",0.28,"-",0.6,"D",0.55,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE1819!I21","v":0}]
[null,20,20,"Q","L","H",0,0,59,0,30,3,5,0,4,"b","e","b","i",53,5,45,8,10,14,19,23,25,24,20,14,9,20,"Q",0.28,"-",0.62,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE1819!I22","v":0}]
[null,21,21,"L","L","L",6,0,0,0,0,0,1,0,8,"b","b","b","b",13,5,82,28,28,28,25,20,14,8,5,3,2,21,"L",0.33,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE1819!I23","v":3}]
[null,22,22,"P","L","L",6,0,76,0,56,2,1,0,7,"b","e","b","e",16,5,80,12,12,11,13,16,21,24,25,22,19,22,"P",0.38,"-",0.56,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE1819!I24","v":0}]
[null,23,23,"I","L","L",5,0,20,0,12,2,1,1,6,"b","b","b","i",19,13,72,17,19,23,24,22,18,15,12,12,11,23,"I",0.36,"-",0.55,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE1819!I25","v":0}]
[null,24,24,"K","L","L",4,0,147,0,72,2,1,1,6,"b","e","b","e",20,14,69,4,5,7,10,13,18,22,25,26,25,24,"K",0.39,"-",0.58,"D",0.57,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE1819!I26","v":-33},{"$nulls":12},"3. Disorder: 27 residues, predicted to be disordered in the full length protein are predicted to not be disordered in the protein produced by NF1delE1819, while 1 residue is predicted to be disordered in the latter but not in neurofibromin. Few of these differences are in isolated single or pairs of residues. 17 (out of those 27) predicted changes are localized in a 20-residue long sequence within the CSRD, positions 796-815 in NF1fl, indicating a potental loss of flexibility that could be functionaly critical. However, all predictions have very low or low reliability."]
[null,25,25,"T","L","L",6,0,127,0,90,2,1,1,7,"b","e","b","e",14,11,76,9,9,9,11,14,17,20,23,26,27,25,"T",0.41,"-",0.56,"D",0.5,"-",0.384,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE1819!I27","v":-25}]
[null,26,26,"G","L","L",6,0,10,0,12,0,0,1,7,"b","b","b","i",10,12,81,19,19,20,21,20,19,18,16,15,14,26,"G",0.39,"-",0.49,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE1819!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,0,7,"b","e","b","e",13,10,78,11,11,13,16,18,21,22,22,22,21,27,"Q",0.42,"-",0.58,"D",0.76,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE1819!I29","v":0}]
[null,28,28,"Q","L","L",4,0,110,0,56,1,2,1,6,"b","e","b","e",23,16,63,10,11,13,16,18,20,21,22,21,20,28,"Q",0.48,"-",0.64,"D",0.77,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE1819!I30","v":-27}]
[null,29,29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",28,16,61,12,12,13,16,18,20,21,21,20,19,29,"N",0.39,"-",0.6,"D",0.66,"D",0.52,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE1819!I31","v":0}]
[null,30,30,"T","L","L",2,0,28,0,20,0,3,1,5,"b","e","b","i",32,15,57,15,16,17,19,20,20,19,17,15,13,30,"T",0.38,"-",0.56,"D",0.66,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE1819!I32","v":0}]
[null,31,31,"H","L","L",1,0,55,0,30,0,3,1,5,"b","e","b","i",36,16,52,11,12,14,17,19,21,21,20,18,16,31,"H",0.34,"-",0.58,"D",0.76,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE1819!I33","v":22}]
[null,32,32,"T","L","L",1,0,59,0,42,0,3,1,5,"b","e","b","e",39,12,54,12,12,13,16,17,19,20,20,20,19,32,"T",0.26,"-",0.6,"D",0.7,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE1819!I34","v":0}]
[null,33,33,"K","L","H",0,0,86,0,42,1,4,1,4,"b","e","b","e",47,12,46,8,8,10,13,16,20,22,22,20,18,33,"K",0.32,"-",0.47,"D",0.68,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE1819!I35","v":0},{"$nulls":12},"4. Protein Binding: Deletion of E1819 leads to 16 newly predicted potential protein binding sites (CSRD: two; GRD: two; Sec14&PH: four), while 12 potential binding sites predicted in full length NF1 are now predicted to be lost in the protein NF1del1819 (CSRD: three) - in addition to those in the deleted exon. "]
[null,34,34,"V","L","H",1,0,42,0,30,1,5,0,3,"b","e","b","i",54,10,38,15,15,16,19,20,21,19,17,14,12,34,"V",0.26,"-",0.55,"D",0.79,"D",0.52,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE1819!I36","v":-14}]
[null,35,35,"S","L","H",2,0,26,0,20,0,5,0,3,"b","e","b","i",60,10,33,18,17,17,18,19,19,19,17,14,11,35,"S",0.22,"-",0.5,"D",0.86,"D",0.429,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE1819!I37","v":13}]
[null,36,36,"T","L","H",4,0,28,0,20,0,6,0,2,"b","e","b","i",68,6,27,19,19,19,20,21,21,19,15,11,8,36,"T",0.17,"-",0.53,"D",0.77,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE1819!I38","v":0}]
[null,37,37,"E","L","H",5,0,108,0,56,3,7,0,1,"b","e","b","e",76,7,19,5,5,7,10,14,18,23,25,24,22,37,"E",0.13,"-",0.56,"D",0.62,"D",0.404,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE1819!I39","v":0}]
[null,38,38,"H","L","H",5,0,36,0,20,1,7,0,1,"b","e","b","i",75,8,20,17,17,18,20,22,22,20,16,11,8,38,"H",0.14,"-",0.46,"-",0.35,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE1819!I40","v":0}]
[null,39,39,"N","L","H",5,0,0,0,0,4,7,0,2,"b","b","b","b",74,6,23,31,27,20,17,15,12,10,8,5,4,39,"N",0.12,"-",0.36,"-",0.47,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE1819!I41","v":0}]
[null,40,40,"K","L","H",7,0,61,0,30,2,8,0,1,"b","e","b","i",85,4,13,12,13,15,19,22,24,23,19,13,10,40,"K",0.14,"-",0.41,"-",0.33,"-",0.31,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G42-delE1819!I42","v":0}]
[null,41,41,"E","L","H",7,0,81,0,42,2,8,0,1,"b","e","b","e",84,5,13,12,13,14,16,19,22,23,22,18,15,41,"E",0.16,"-",0.46,"-",0.36,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G43-delE1819!I43","v":0}]
[null,42,42,"C","L","H",6,0,0,0,0,3,7,1,1,"b","b","b","b",78,13,13,30,27,23,20,17,13,10,6,3,2,42,"C",0.18,"-",0.29,"-",0.41,"-",0.28,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G44-delE1819!I44","v":0}]
[null,43,43,"L","L","H",5,0,0,0,0,8,6,1,1,"b","b","b","b",71,21,14,42,33,19,13,10,7,5,3,2,2,43,"L",0.18,"-",0.27,"-",0.32,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G45-delE1819!I45","v":0}]
[null,44,44,"I","L","H",4,0,0,0,0,3,6,2,1,"b","b","b","b",66,22,18,31,28,22,18,15,11,9,6,4,3,44,"I",0.11,"-",0.4,"-",0.4,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G46-delE1819!I46","v":0}]
[null,45,45,"N","L","H",4,0,47,0,30,1,6,1,2,"b","e","b","i",66,17,23,17,17,17,20,21,22,20,16,11,9,45,"N",0.07,"-",0.38,"-",0.21,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G47-delE1819!I47","v":0}]
[null,46,46,"I","L","H",3,0,0,0,0,5,6,1,2,"b","b","b","b",64,13,28,36,31,23,18,14,10,6,4,3,2,46,"I",0.07,"-",0.4,"-",0.2,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G48-delE1819!I48","v":0}]
[null,47,47,"S","L","H",1,0,0,0,0,5,5,0,3,"b","b","b","b",54,9,41,35,30,22,17,14,11,8,6,4,3,47,"S",0.06,"-",0.43,"-",0.19,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G49-delE1819!I49","v":0}]
[null,48,48,"K","L","H",3,0,86,0,42,1,6,0,3,"b","e","b","e",65,6,33,14,14,14,16,19,21,23,22,20,18,48,"K",0.07,"-",0.57,"D",0.2,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G50-delE1819!I50","v":0}]
[null,49,49,"Y","L","H",1,0,26,0,12,1,5,0,4,"b","b","b","i",56,6,42,18,19,20,23,23,21,17,13,9,7,49,"Y",0.08,"-",0.49,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G51-delE1819!I51","v":0}]
[null,50,50,"K","L","H",2,0,41,0,20,0,5,0,3,"b","e","b","i",60,6,37,18,17,17,19,21,21,19,15,10,8,50,"K",0.09,"-",0.47,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G52-delE1819!I52","v":0}]
[null,51,51,"F","L","H",4,0,0,0,0,4,6,0,2,"b","b","b","b",72,6,25,34,30,23,18,14,11,7,5,3,2,51,"F",0.11,"-",0.35,"-",0.26,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G53-delE1819!I53","v":0}]
[null,52,52,"S","L","H",6,0,0,0,0,1,8,0,1,"b","b","b","b",84,4,15,25,23,20,19,18,16,14,11,7,5,52,"S",0.09,"-",0.32,"-",0.18,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G54-delE1819!I54","v":0}]
[null,53,53,"L","L","H",8,0,0,0,0,4,8,0,0,"b","b","b","b",91,4,7,32,28,19,16,13,11,8,5,3,2,53,"L",0.14,"-",0.29,"-",0.15,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G55-delE1819!I55","v":0}]
[null,54,54,"V","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",94,3,5,46,36,17,11,7,4,2,1,0,0,54,"V",0.09,"-",0.26,"-",0.18,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G56-delE1819!I56","v":0}]
[null,55,55,"I","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,2,4,44,34,16,10,7,4,2,1,0,0,55,"I",0.06,"-",0.26,"-",0.13,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G57-delE1819!I57","v":0}]
[null,56,56,"S","L","H",8,0,0,0,0,2,9,0,0,"b","b","b","b",94,1,5,26,24,20,18,17,15,11,8,4,3,56,"S",0.07,"-",0.33,"-",0.13,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G58-delE1819!I58","v":0}]
[null,57,57,"G","L","H",8,0,0,0,0,6,9,0,0,"b","b","b","b",93,1,6,34,28,18,14,12,9,6,4,2,1,57,"G",0.08,"-",0.26,"-",0.14,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G59-delE1819!I59","v":0}]
[null,58,58,"L","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",96,0,3,48,36,15,8,5,3,1,0,0,0,58,"L",0.08,"-",0.27,"-",0.18,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G60-delE1819!I60","v":0}]
[null,59,59,"T","L","H",9,0,0,0,0,2,9,0,0,"b","b","b","b",95,1,3,28,25,20,19,16,13,9,6,3,2,59,"T",0.1,"-",0.35,"-",0.18,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G61-delE1819!I61","v":0}]
[null,60,60,"T","L","H",8,0,42,0,30,3,9,0,0,"b","e","b","i",92,1,7,10,11,13,17,21,24,23,18,10,6,60,"T",0.14,"-",0.41,"-",0.24,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G62-delE1819!I62","v":0}]
[null,61,61,"I","L","H",8,0,0,0,0,3,9,0,0,"b","b","b","b",92,1,7,31,27,21,18,15,11,7,3,1,0,61,"I",0.15,"-",0.36,"-",0.24,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G63-delE1819!I63","v":0}]
[null,62,62,"L","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",93,1,5,43,34,18,11,7,4,3,2,1,0,62,"L",0.15,"-",0.37,"-",0.19,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G64-delE1819!I64","v":0}]
[null,63,63,"K","L","H",8,0,114,0,56,3,9,0,0,"b","e","b","e",91,2,8,5,6,8,11,15,21,26,27,21,16,63,"K",0.12,"-",0.52,"D",0.28,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G65-delE1819!I65","v":0}]
[null,64,64,"N","L","H",6,0,47,0,30,2,8,0,1,"b","e","b","i",80,2,18,11,12,14,18,21,23,21,18,13,9,64,"N",0.2,"-",0.58,"D",0.21,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G66-delE1819!I66","v":0}]
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[null,2767,2659,"S","L","L",5,0,39,0,30,1,1,1,6,"b","e","b","i",20,15,70,15,16,17,19,20,21,20,19,17,16,2659,"S",0.71,"D",0.6,"D",0.47,"-",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2769-delE1819!I2769","v":-13}]
[null,2768,2660,"Q","L","L",5,0,59,0,30,0,1,1,6,"b","e","b","i",19,13,72,11,12,13,16,19,21,21,21,20,20,2660,"Q",0.71,"D",0.66,"D",0.51,"-",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2770-delE1819!I2770","v":24}]
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[null,2774,2666,"D","L","L",3,0,117,0,72,0,2,1,6,"b","e","b","e",30,12,65,10,10,12,15,18,20,22,22,23,22,2666,"D",0.7,"D",0.69,"D",0.75,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2776-delE1819!I2776","v":-49}]
[null,2775,2667,"K","L","L",2,0,147,0,72,1,3,1,5,"b","e","b","e",35,11,62,7,7,10,13,17,20,22,23,24,23,2667,"K",0.67,"D",0.71,"D",0.75,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2777-delE1819!I2777","v":0}]
[null,2776,2668,"E","L","L",4,0,139,0,72,1,2,1,6,"b","e","b","e",25,11,69,6,7,9,13,16,19,21,23,24,24,2668,"E",0.66,"D",0.68,"D",0.75,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2778-delE1819!I2778","v":0}]
[null,2777,2669,"N","L","L",5,0,87,0,56,2,2,1,6,"b","e","b","e",21,12,72,8,9,11,14,16,20,22,24,24,23,2669,"N",0.64,"D",0.65,"D",0.77,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2779-delE1819!I2779","v":-22}]
[null,2778,2670,"V","L","L",5,0,28,0,20,1,2,1,6,"b","e","b","i",21,12,72,14,15,17,20,21,21,19,17,15,14,2670,"V",0.66,"D",0.62,"D",0.86,"D",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2780-delE1819!I2780","v":0}]
[null,2779,2671,"E","L","L",5,0,139,0,72,1,1,1,6,"b","e","b","e",20,15,70,6,7,9,13,16,19,22,23,24,23,2671,"E",0.6,"D",0.61,"D",0.79,"D",0.602,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2781-delE1819!I2781","v":-58}]
[null,2780,2672,"L","L","L",4,0,118,0,72,1,2,1,6,"b","e","b","e",22,14,69,11,11,12,15,17,19,21,22,23,23,2672,"L",0.61,"D",0.54,"D",0.64,"D",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2782-delE1819!I2782","v":-50}]
[null,2781,2673,"S","L","L",6,0,15,0,12,0,1,1,7,"b","b","b","i",13,16,76,20,21,22,23,22,19,16,13,11,9,2673,"S",0.61,"D",0.49,"D",0.44,"-",0.571,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2783-delE1819!I2783","v":0}]
[null,2782,2674,"P","L","L",5,0,40,0,30,0,1,1,7,"b","e","b","i",16,15,74,15,15,16,18,19,21,21,21,21,20,2674,"P",0.58,"D",0.53,"D",0.44,"-",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2784-delE1819!I2784","v":-24}]
[null,2783,2675,"T","L","L",6,0,17,0,12,0,1,1,7,"b","b","b","i",14,14,75,20,20,20,21,21,20,18,15,13,12,2675,"T",0.6,"D",0.47,"D",0.54,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2785-delE1819!I2785","v":-17}]
[null,2784,2676,"T","L","L",5,0,17,0,12,0,1,1,6,"b","b","b","i",17,15,70,20,20,20,21,20,19,17,14,13,12,2676,"T",0.66,"D",0.53,"D",0.44,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2786-delE1819!I2786","v":-17}]
[null,2785,2677,"G","L","L",5,0,35,0,42,0,1,1,7,"b","e","b","e",18,13,73,12,13,13,16,18,21,22,22,21,19,2677,"G",0.7,"D",0.56,"D",0.6,"D",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2787-delE1819!I2787","v":-10}]
[null,2786,2678,"H","L","L",4,0,55,0,30,1,2,1,6,"b","e","b","i",22,16,67,13,14,16,19,21,22,21,20,18,17,2678,"H",0.7,"D",0.56,"D",0.57,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2788-delE1819!I2788","v":0}]
[null,2787,2679,"C","L","L",5,0,27,0,20,1,1,1,6,"b","e","b","i",19,14,70,14,15,17,19,21,21,19,16,15,14,2679,"C",0.69,"D",0.53,"D",0.57,"-",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2789-delE1819!I2789","v":0}]
[null,2788,2680,"N","L","L",6,0,141,0,90,1,1,1,7,"b","e","b","e",14,11,76,9,9,10,13,15,18,20,22,25,26,2680,"N",0.67,"D",0.47,"D",0.55,"-",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2790-delE1819!I2790","v":0}]
[null,2789,2681,"S","L","L",6,0,26,0,20,0,1,1,7,"b","e","b","i",13,13,76,14,14,16,18,20,20,20,18,17,16,2681,"S",0.58,"D",0.53,"D",0.52,"-",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2791-delE1819!I2791","v":67}]
[null,2790,2682,"G","L","L",6,0,16,0,20,0,1,1,7,"b","e","b","i",14,14,75,15,15,16,18,20,20,20,18,17,16,2682,"G",0.46,"-",0.43,"-",0.57,"-",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2792-delE1819!I2792","v":9}]
[null,2791,2683,"R","L","L",4,0,49,0,20,1,1,1,6,"b","e","b","i",15,20,69,14,15,17,20,22,22,20,17,15,13,2683,"R",0.52,"D",0.54,"D",0.59,"D",0.612,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2793-delE1819!I2793","v":0}]
[null,2792,2684,"T","L","L",4,0,28,0,20,0,1,1,6,"b","e","b","i",18,20,68,18,18,18,20,21,21,19,17,14,12,2684,"T",0.56,"D",0.54,"D",0.74,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2794-delE1819!I2794","v":0}]
[null,2793,2685,"R","L","L",4,0,29,0,12,1,1,2,6,"b","b","b","i",17,23,66,18,19,20,22,22,20,17,13,10,8,2685,"R",0.55,"D",0.44,"-",0.76,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2795-delE1819!I2795","v":0}]
[null,2794,2686,"H","L","L",4,0,0,0,0,0,1,2,6,"b","b","b","b",15,22,68,21,21,20,20,20,19,16,14,12,11,2686,"H",0.61,"D",0.51,"D",0.66,"D",0.633,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2796-delE1819!I2796","v":0}]
[null,2795,2687,"G","L","L",5,0,10,0,12,0,1,1,6,"b","b","b","i",18,16,73,19,20,20,22,21,21,19,16,14,12,2687,"G",0.58,"D",0.54,"D",0.73,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2797-delE1819!I2797","v":0}]
[null,2796,2688,"S","L","L",4,0,0,0,0,0,2,1,6,"b","b","b","b",27,15,68,22,21,20,20,20,19,18,16,15,14,2688,"S",0.65,"D",0.47,"D",0.83,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2798-delE1819!I2798","v":0}]
[null,2797,2689,"A","L","L",1,0,0,0,0,0,3,1,5,"b","b","b","b",45,12,57,22,21,20,21,20,19,17,15,14,13,2689,"A",0.72,"D",0.45,"-",0.87,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2799-delE1819!I2799","v":0}]
[null,2798,2690,"S","L","L",1,0,93,0,72,0,4,1,4,"b","e","b","e",45,12,55,12,12,13,16,18,19,20,21,22,22,2690,"S",0.69,"D",0.57,"D",0.87,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2800-delE1819!I2800","v":-54}]
[null,2799,2691,"Q","L","L",1,0,83,0,42,2,3,1,5,"b","e","b","e",39,15,57,7,9,12,16,20,23,25,24,21,18,2691,"Q",0.65,"D",0.65,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE1819!I2801","v":0}]
[null,2800,2692,"V","L","L",3,0,17,0,12,0,2,1,5,"b","b","b","i",29,19,60,18,18,19,21,21,19,17,15,13,13,2692,"V",0.65,"D",0.63,"D",0.91,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE1819!I2802","v":11}]
[null,2801,2693,"Q","L","L",4,0,59,0,30,0,2,2,5,"b","e","b","i",22,22,65,11,11,14,17,20,22,22,21,19,17,2693,"Q",0.68,"D",0.69,"D",0.88,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE1819!I2803","v":24}]
[null,2802,2694,"K","L","L",5,0,147,0,72,2,1,1,6,"b","e","b","e",20,17,70,7,8,10,13,16,20,23,25,27,26,2694,"K",0.66,"D",0.66,"D",0.9,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE1819!I2804","v":0}]
[null,2803,2695,"Q","L","L",5,0,83,0,42,0,1,1,6,"b","e","b","e",17,17,73,7,8,11,16,19,21,22,22,22,21,2695,"Q",0.54,"D",0.62,"D",0.79,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE1819!I2805","v":27}]
[null,2804,2696,"R","L","L",6,0,104,0,42,0,1,1,7,"b","e","b","e",16,14,76,9,10,12,15,18,21,23,23,23,22,2696,"R",0.56,"D",0.65,"D",0.87,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE1819!I2806","v":34}]
[null,2805,2697,"S","L","L",5,0,15,0,12,0,1,1,6,"b","b","b","i",19,14,71,17,17,18,20,20,20,18,17,16,15,2697,"S",0.59,"D",0.58,"D",0.93,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE1819!I2807","v":11}]
[null,2806,2698,"A","L","L",3,0,44,0,42,0,2,1,6,"b","e","b","e",27,15,66,13,14,15,17,19,20,21,20,20,19,2698,"A",0.64,"D",0.59,"D",0.92,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE1819!I2808","v":-13}]
[null,2807,2699,"G","L","L",3,0,25,0,30,0,2,1,6,"b","e","b","i",26,16,65,14,14,15,18,20,22,22,20,19,17,2699,"G",0.63,"D",0.51,"D",0.85,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE1819!I2809","v":0}]
[null,2808,2700,"S","L","L",4,0,0,0,0,0,2,1,6,"b","b","b","b",26,16,67,21,20,19,20,20,20,18,17,15,14,2700,"S",0.6,"D",0.53,"D",0.73,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE1819!I2810","v":0}]
[null,2809,2701,"F","L","L",2,0,0,0,0,0,2,2,4,"b","b","b","b",30,25,54,25,25,23,23,20,16,12,9,9,8,2701,"F",0.68,"D",0.61,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE1819!I2811","v":0}]
[null,2810,2702,"K","L","L",2,0,114,0,56,2,2,2,4,"b","e","b","e",31,23,53,6,7,8,12,16,21,24,25,23,21,2702,"K",0.62,"D",0.57,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE1819!I2812","v":-28}]
[null,2811,2703,"R","L","L",0,0,74,0,30,1,3,1,4,"b","e","b","i",42,17,48,8,10,13,18,22,24,23,21,18,16,2703,"R",0.69,"D",0.62,"D",0.86,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE1819!I2813","v":0}]
[null,2812,2704,"N","L","L",1,0,65,0,42,0,3,1,4,"b","e","b","e",44,13,54,9,9,11,15,18,20,21,21,21,21,2704,"N",0.35,"-",0.73,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE1819!I2814","v":48}]
[null,2813,2705,"S","L","L",0,0,72,0,56,1,4,1,4,"b","e","b","e",49,15,51,9,9,11,15,18,20,22,23,23,23,2705,"S",0.28,"-",0.61,"D",0.8,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE1819!I2815","v":0}]
[null,2814,2706,"I","L","L",1,0,121,0,72,0,3,1,4,"b","e","b","e",42,16,55,10,11,12,15,18,20,21,22,23,22,2706,"I",0.44,"-",0.62,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE1819!I2816","v":-71}]
[null,2815,2707,"K","L","L",3,0,147,0,72,3,2,2,5,"b","e","b","e",28,23,58,3,3,6,9,13,17,22,26,28,27,2707,"K",0.34,"-",0.67,"D",0.81,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE1819!I2817","v":0}]
[null,2816,2708,"K","L","L",2,0,147,0,72,2,1,2,5,"b","e","b","e",21,31,56,5,5,7,10,14,17,21,23,26,26,2708,"K",0.37,"-",0.79,"D",0.77,"D",0.571,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE1819!I2818","v":0}]
[null,2817,2709,"I","L","L",3,0,121,0,72,0,1,2,6,"b","e","b","e",12,29,62,9,10,12,15,18,19,19,18,20,20,2709,"I",0.37,"-",0.77,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE1819!I2819","v":-101}]
[null,2818,2710,"V","L","L",8,0,127,0,90,5,0,0,8,"b","e","b","e",3,8,90,4,4,5,7,9,12,15,18,28,32,2710,"V",0.33,"-",0.83,"D",0.74,"D",0.535,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE1819!I2820","v":0}]
[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":2571}]
[{"$nulls":55},{"$f":"SUM(BD2:BD2820)-SUM(BD670:BD777)","v":-154}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},108,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":85},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":107},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":205},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":62},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":244},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.03136531365313653,"d":"3%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.09003690036900369,"d":"9%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":125},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":85},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":31},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":2},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":1},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":50},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":15},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":8},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":7},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":2},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":2},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":1},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":16}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":27},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":12}]

{"sheet":"delE20","index":5,"n_rows":2864,"n_cols":69,"rows_kept":1125,"cut":true,"merged":[[0,2,0,43],[7,68,12,118],[14,68,22,118],[24,68,29,118],[33,68,35,118],[777,2,804,43],[1175,0,1572,0],[2822,54,2834,55]],"bounds":{"rows_first":500,"rows_last":125,"rows_between":500,"halvings":2}}
[null,null,"delE20"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE20)"]
[null,1,1,"M","L","L",9,0,169,0,90,4,0,0,9,"b","e","b","e",1,1,96,8,7,7,9,11,13,14,16,24,28,1,"M",0.32,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE20!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",8,7,86,6,6,7,10,13,16,19,21,26,28,2,"A",0.21,"-",0.86,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE20!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",7,0,76,0,72,1,1,0,8,"b","e","b","e",13,7,83,6,7,9,13,16,20,23,24,25,24,3,"A",0.1,"-",0.83,"D",0.36,"-",0.556,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE20!I5","v":0},{"$nulls":12},"SUMMARY: "]
[null,4,4,"H","L","L",5,0,132,0,72,2,1,0,7,"b","e","b","e",20,10,73,6,6,8,12,15,19,22,25,27,27,4,"H",0.12,"-",0.84,"D",0.29,"-",0.505,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE20!I6","v":0}]
[null,5,5,"R","L","L",6,0,104,0,42,3,1,0,7,"b","e","b","e",16,9,76,6,7,10,15,21,25,27,24,20,16,5,"R",0.1,"-",0.7,"D",0.34,"-",0.449,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE20!I7","v":0}]
[null,6,6,"P","L","L",1,0,40,0,30,1,4,0,5,"b","e","b","i",41,5,56,16,16,17,19,21,22,21,18,15,13,6,"P",0.09,"-",0.62,"D",0.34,"-",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE20!I8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (3%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of full length neurofibromin. While the majority of predicted changes in secondary structure has very low or low reliability (RI_S = 0-3), 11 predicted changes in residue secondary structure have a high to very high relibility (RI_S = 6-9). All these residues are located in the CSRD and part of a 14 residue long subsequence (positions 804-817) that has also predicted changes to solvent accessibility and order/disorder status."]
[null,7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",69,4,33,13,14,16,19,20,20,19,16,13,10,7,"V",0.21,"-",0.61,"D",0.28,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE20!I9","v":0}]
[null,8,8,"E","L","H",6,0,108,0,56,2,7,0,1,"b","e","b","e",81,7,15,6,7,9,12,16,20,24,25,21,18,8,"E",0.26,"-",0.54,"D",0.23,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE20!I10","v":0}]
[null,9,9,"W","L","H",8,0,0,0,0,3,8,0,0,"b","b","b","b",89,4,8,31,28,24,21,18,14,9,5,2,1,9,"W",0.21,"-",0.4,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE20!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,7,9,0,0,"b","b","b","b",91,3,7,40,33,19,14,10,7,4,2,1,0,10,"V",0.12,"-",0.31,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE20!I12","v":0}]
[null,11,11,"Q","L","H",8,0,59,0,30,2,9,0,0,"b","e","b","i",93,1,5,15,15,16,19,21,23,21,16,9,5,11,"Q",0.1,"-",0.28,"-",0.18,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE20!I13","v":0}]
[null,12,12,"A","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",92,1,6,23,22,21,22,21,19,15,10,5,2,12,"A",0.12,"-",0.27,"-",0.25,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE20!I14","v":0}]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,47,35,16,9,6,3,2,1,0,0,13,"V",0.11,"-",0.24,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE20!I15","v":0},{"$nulls":12},"2. Solvent Accessibility: 211 residues (8%) are predicted to have changed their classification (according to Pbie or Pbe, with b=burried, i=intermediate, e=exposed). Almost all predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-3), while three have medium (RI_A = 4), one has high (RI_A = 6)  and another has very high reliability (RI_A = 8). The latter two are changes from exposed to burried. Changes with medium to very high reliability are all located in the CSRD, adjacent to the deleted exon sequence. NF1delE20's net solvent accessibility appears to be increased compared to neurofibromin, if we disregard the lost solvent accessibility due to the deleted exon. "]
[null,14,14,"V","L","H",9,0,0,0,0,5,9,0,0,"b","b","b","b",95,1,4,34,29,20,16,13,10,7,4,2,1,14,"V",0.12,"-",0.32,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE20!I16","v":0}]
[null,15,15,"S","L","H",8,0,54,0,42,3,9,0,0,"b","e","b","e",91,1,8,8,9,11,14,18,22,24,21,14,9,15,"S",0.14,"-",0.41,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE20!I17","v":0}]
[null,16,16,"R","L","H",7,0,29,0,12,3,8,0,1,"b","b","b","i",89,2,11,16,18,22,26,26,22,16,9,4,2,16,"R",0.14,"-",0.39,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE20!I18","v":0}]
[null,17,17,"F","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",90,1,9,42,34,20,13,9,6,3,2,1,0,17,"F",0.21,"-",0.4,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE20!I19","v":0}]
[null,18,18,"D","L","H",7,0,68,0,42,2,8,0,1,"b","e","b","e",89,2,11,12,12,14,17,20,23,24,21,15,11,18,"D",0.24,"-",0.59,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE20!I20","v":0}]
[null,19,19,"E","L","H",4,0,139,0,72,3,7,0,2,"b","e","b","e",73,3,28,4,5,6,9,12,16,21,26,27,26,19,"E",0.28,"-",0.59,"D",0.55,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE20!I21","v":0}]
[null,20,20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",57,4,43,8,10,14,20,23,26,24,20,14,9,20,"Q",0.27,"-",0.6,"D",0.49,"-",0.32,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE20!I22","v":0}]
[null,21,21,"L","L","L",6,0,3,0,2,3,1,0,8,"b","b","b","b",15,4,81,28,29,28,25,19,13,8,5,3,2,21,"L",0.31,"-",0.59,"D",0.5,"-",0.3,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE20!I23","v":0}]
[null,22,22,"P","L","L",7,0,76,0,56,2,1,0,8,"b","e","b","e",11,6,84,12,11,11,13,16,20,24,25,22,20,22,"P",0.36,"-",0.58,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE20!I24","v":0}]
[null,23,23,"I","L","L",5,0,20,0,12,2,1,1,6,"b","b","b","i",18,13,72,17,20,23,24,22,18,14,12,11,11,23,"I",0.34,"-",0.54,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE20!I25","v":0},{"$nulls":12},"3. Disorder: 21 residues, predicted to be disordered in the full length protein, are predicted to be ordered in the protein produced by NF1delE20, while 2 residues are predicted to be disordered in the latter but not in neurofibromin. Out of those 21, 11 residues are in the CSRD at positions 804-815. The suggested change of flexibility in this 12 residue-long region has medium to high reliability and could potentially hinder conformational changes critical for protein function."]
[null,24,24,"K","L","L",5,0,147,0,72,2,1,1,6,"b","e","b","e",19,15,69,4,5,7,10,14,18,22,25,26,25,24,"K",0.38,"-",0.56,"D",0.57,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE20!I26","v":-33}]
[null,25,25,"T","L","L",6,0,102,0,72,2,1,1,7,"b","e","b","e",14,11,76,9,9,9,11,14,17,20,23,26,26,25,"T",0.39,"-",0.56,"D",0.5,"-",0.384,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE20!I27","v":0}]
[null,26,26,"G","L","L",6,0,10,0,12,0,0,1,7,"b","b","b","i",10,12,80,20,20,20,21,20,19,18,16,15,14,26,"G",0.37,"-",0.48,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE20!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,1,7,"b","e","b","e",13,12,74,11,12,14,17,19,21,22,22,21,20,27,"Q",0.42,"-",0.57,"D",0.76,"D",0.469,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE20!I29","v":0}]
[null,28,28,"Q","L","L",3,0,110,0,56,1,2,1,6,"b","e","b","e",22,17,61,10,11,13,16,18,20,21,22,21,20,28,"Q",0.49,"-",0.62,"D",0.77,"D",0.51,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE20!I30","v":-27}]
[null,29,29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",27,18,59,11,12,13,16,18,20,21,21,20,19,29,"N",0.38,"-",0.6,"D",0.66,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE20!I31","v":0}]
[null,30,30,"T","L","L",2,0,28,0,20,0,2,1,5,"b","e","b","i",30,18,55,16,16,17,19,20,20,19,17,15,13,30,"T",0.37,"-",0.56,"D",0.66,"D",0.48,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE20!I32","v":0}]
[null,31,31,"H","L","L",1,0,77,0,42,1,3,1,5,"b","e","b","e",35,15,54,11,12,14,17,18,20,21,20,18,16,31,"H",0.33,"-",0.59,"D",0.76,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE20!I33","v":0}]
[null,32,32,"T","L","L",1,0,59,0,42,0,3,1,4,"b","e","b","e",39,14,52,12,12,13,16,18,19,20,20,19,18,32,"T",0.25,"-",0.58,"D",0.7,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE20!I34","v":0},{"$nulls":12},"4. Protein Binding: Deletion of E20 leads to 13 newly predicted potential protein binding sites (CSRD: two; GRD: two; Sec14&PH: one), while 13 potential binding sites, predicted in full length NF1, are now predicted to be lost (CSRD: three; Sec14&PH: one) - in addition to those in the deleted exon. "]
[null,33,33,"K","L","L",0,0,86,0,42,1,4,1,4,"b","e","b","e",45,13,46,8,9,10,13,16,20,22,22,20,18,33,"K",0.31,"-",0.47,"D",0.68,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE20!I35","v":0}]
[null,34,34,"V","L","H",1,0,28,0,20,0,5,0,3,"b","e","b","i",54,10,39,14,15,16,18,20,20,20,18,16,14,34,"V",0.27,"-",0.56,"D",0.79,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE20!I36","v":0}]
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[null,2799,2771,"Q","L","L",0,0,83,0,42,2,4,0,4,"b","e","b","e",45,10,51,9,10,13,17,21,23,24,22,19,17,2771,"Q",0.7,"D",0.65,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE20!I2801","v":0}]
[null,2800,2772,"V","L","L",1,0,17,0,12,0,3,1,5,"b","b","b","i",35,16,54,20,20,20,21,20,19,16,14,12,11,2772,"V",0.67,"D",0.61,"D",0.91,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE20!I2802","v":11}]
[null,2801,2773,"Q","L","L",3,0,83,0,42,1,2,1,5,"b","e","b","e",28,20,62,13,14,15,18,20,22,23,21,18,16,2773,"Q",0.69,"D",0.67,"D",0.88,"D",0.653,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE20!I2803","v":0}]
[null,2802,2774,"K","L","L",4,0,114,0,56,3,2,1,6,"b","e","b","e",22,17,70,7,7,9,12,16,20,24,26,26,25,2774,"K",0.7,"D",0.69,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE20!I2804","v":33}]
[null,2803,2775,"Q","L","L",5,0,83,0,42,0,1,1,6,"b","e","b","e",17,16,74,7,8,11,15,19,22,23,23,22,20,2775,"Q",0.62,"D",0.6,"D",0.79,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE20!I2805","v":27}]
[null,2804,2776,"R","L","L",6,0,104,0,42,0,1,1,7,"b","e","b","e",16,15,76,10,11,13,16,19,21,22,22,22,21,2776,"R",0.67,"D",0.67,"D",0.87,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE20!I2806","v":34}]
[null,2805,2777,"S","L","L",6,0,39,0,30,0,1,1,7,"b","e","b","i",16,12,78,11,12,15,19,21,22,21,20,19,18,2777,"S",0.68,"D",0.63,"D",0.93,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE20!I2807","v":-13}]
[null,2806,2778,"A","L","L",5,0,95,0,90,1,2,0,6,"b","e","b","e",22,10,74,8,9,9,12,14,18,21,23,26,27,2778,"A",0.66,"D",0.66,"D",0.92,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE20!I2808","v":-64}]
[null,2807,2779,"G","L","L",5,0,10,0,12,0,2,0,6,"b","b","b","i",22,10,72,19,19,20,22,21,19,17,16,15,14,2779,"G",0.6,"D",0.56,"D",0.85,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE20!I2809","v":15}]
[null,2808,2780,"S","L","L",4,0,39,0,30,0,2,1,6,"b","e","b","i",26,15,68,16,15,15,17,19,21,21,21,20,19,2780,"S",0.6,"D",0.55,"D",0.73,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE20!I2810","v":-39}]
[null,2809,2781,"F","L","L",3,0,0,0,0,0,2,1,5,"b","b","b","b",28,20,59,23,23,23,23,21,17,13,10,9,9,2781,"F",0.71,"D",0.62,"D",0.83,"D",0.653,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE20!I2811","v":0}]
[null,2810,2782,"K","L","L",3,0,114,0,56,3,2,1,5,"b","e","b","e",28,18,62,6,7,8,11,15,19,22,25,25,24,2782,"K",0.6,"D",0.59,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE20!I2812","v":-28}]
[null,2811,2783,"R","L","L",1,0,74,0,30,1,3,1,5,"b","e","b","i",41,13,55,8,9,13,17,21,23,23,21,19,16,2783,"R",0.67,"D",0.61,"D",0.86,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE20!I2813","v":0}]
[null,2812,2784,"N","L","L",0,0,113,0,72,2,4,0,4,"b","e","b","e",49,9,54,5,6,7,11,14,18,21,24,26,26,2784,"N",0.38,"-",0.71,"D",0.83,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE20!I2814","v":0}]
[null,2813,2785,"S","L","H",1,0,54,0,42,0,5,0,3,"b","e","b","e",60,11,41,10,11,13,16,18,20,22,22,22,21,2785,"S",0.25,"-",0.57,"D",0.8,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE20!I2815","v":18}]
[null,2814,2786,"I","L","H",2,0,33,0,20,0,5,1,3,"b","e","b","i",61,13,40,16,16,16,18,20,20,20,18,17,16,2786,"I",0.43,"-",0.56,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE20!I2816","v":17}]
[null,2815,2787,"K","L","H",0,0,147,0,72,2,4,1,3,"b","e","b","e",52,16,44,3,3,6,10,14,18,23,26,27,26,2787,"K",0.3,"-",0.72,"D",0.81,"D",0.663,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE20!I2817","v":0}]
[null,2816,2788,"K","L","L",1,0,147,0,72,2,3,2,4,"b","e","b","e",39,23,53,4,5,7,10,14,19,24,26,27,26,2788,"K",0.34,"-",0.8,"D",0.77,"D",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE20!I2818","v":0}]
[null,2817,2789,"I","L","L",4,0,20,0,12,1,2,1,6,"b","b","b","i",22,20,66,16,17,19,21,20,18,15,13,13,13,2789,"I",0.32,"-",0.77,"D",0.77,"D",0.582,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE20!I2819","v":0}]
[null,2818,2790,"V","L","L",8,0,127,0,90,3,0,0,9,"b","e","b","e",3,7,91,7,6,7,8,10,13,16,18,25,28,2790,"V",0.37,"-",0.85,"D",0.74,"D",0.551,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE20!I2820","v":0}]
[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":984}]
[{"$nulls":55},{"$f":"SUM(BD2:BD2820)-SUM(BD778:BD805)","v":-601}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},28,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":74},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":78},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":176},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":32},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":211},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.026523297491039426,"d":"3%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.07562724014336918,"d":"8%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":103},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":76},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":25},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":2},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":3},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":1},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":1},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":56},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":4},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":2},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":4},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":2},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":13}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":21},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":13}]

{"sheet":"delE21","index":6,"n_rows":2864,"n_cols":69,"rows_kept":2250,"cut":true,"merged":[[0,2,0,43],[7,68,10,118],[14,68,20,118],[24,68,29,118],[33,68,35,118],[1175,0,1572,0],[2822,54,2834,55]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
[null,null,"delE21"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE21)"]
[null,1,1,"M","L","L",9,0,169,0,90,3,0,0,9,"b","e","b","e",1,1,96,9,9,8,10,11,13,14,16,24,27,1,"M",0.31,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE21!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",8,8,85,7,7,8,11,14,17,19,20,25,26,2,"A",0.21,"-",0.85,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE21!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",6,0,76,0,72,1,1,0,7,"b","e","b","e",12,9,81,8,8,10,13,16,20,22,23,24,23,3,"A",0.09,"-",0.82,"D",0.36,"-",0.545,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE21!I5","v":0},{"$nulls":12},"SUMMARY:"]
[null,4,4,"H","L","L",5,0,132,0,72,1,1,1,6,"b","e","b","e",20,12,72,7,8,9,13,16,20,23,24,25,24,4,"H",0.12,"-",0.83,"D",0.29,"-",0.495,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE21!I6","v":0}]
[null,5,5,"R","L","L",5,0,104,0,42,1,1,1,7,"b","e","b","e",17,12,74,9,10,12,16,20,23,24,23,20,18,5,"R",0.1,"-",0.68,"D",0.34,"-",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE21!I7","v":0}]
[null,6,6,"P","L","L",2,0,40,0,30,2,3,0,5,"b","e","b","i",37,8,60,14,14,15,19,21,23,22,19,15,13,6,"P",0.08,"-",0.61,"D",0.34,"-",0.404,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE21!I8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (5%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of full length neurofibromin. All predicted changes in secondary structure have very low (RI_S = 0-1) or low relibility (RI_S = 2-3). "]
[null,7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",65,5,35,14,15,17,20,21,21,18,16,12,10,7,"V",0.21,"-",0.58,"D",0.28,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE21!I9","v":0}]
[null,8,8,"E","L","H",5,0,81,0,42,2,7,0,1,"b","e","b","e",77,7,19,10,11,12,15,18,20,22,22,18,15,8,"E",0.24,"-",0.54,"D",0.23,"-",0.31,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE21!I10","v":27}]
[null,9,9,"W","L","H",7,0,0,0,0,2,8,0,0,"b","b","b","b",87,5,9,30,28,24,22,19,15,9,5,2,1,9,"W",0.21,"-",0.38,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE21!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,8,8,0,0,"b","b","b","b",90,4,7,41,33,19,14,10,7,4,2,1,0,10,"V",0.12,"-",0.3,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE21!I12","v":0}]
[null,11,11,"Q","L","H",8,0,0,0,0,1,9,0,0,"b","b","b","b",93,2,5,24,22,19,19,18,17,14,11,6,4,11,"Q",0.09,"-",0.28,"-",0.18,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE21!I13","v":59}]
[null,12,12,"A","L","H",8,0,0,0,0,2,9,0,0,"b","b","b","b",93,2,5,27,25,21,20,19,17,13,8,4,2,12,"A",0.14,"-",0.24,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE21!I14","v":0}]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,1,3,47,36,15,8,5,3,2,1,0,0,13,"V",0.12,"-",0.24,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE21!I15","v":0},{"$nulls":12},"2. Solvent Accessibility: 376 residues (14%) are predicted to have changed their classification (according to Pbie or Pbe, with b=burried, i=intermediate, e=exposed). Almost all predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-4), except for one, which has medium reliability (RI_A = 5). The latter is a change from exposed to burried and is located in the CSRD, adjacent to the deleted exon sequence. NF1delE21 will possibly have a solvent accessibility that is further reduced, beyond what is attributed to the deleted exon. "]
[null,14,14,"V","L","H",9,0,0,0,0,6,9,0,0,"b","b","b","b",95,1,3,37,31,20,15,11,8,5,3,1,0,14,"V",0.13,"-",0.33,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE21!I16","v":0}]
[null,15,15,"S","L","H",8,0,39,0,30,3,9,0,0,"b","e","b","i",91,2,7,12,12,14,18,21,24,22,18,11,7,15,"S",0.14,"-",0.41,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE21!I17","v":15}]
[null,16,16,"R","L","H",8,0,29,0,12,3,8,0,0,"b","b","b","i",90,2,9,15,18,23,27,26,23,16,9,4,1,16,"R",0.14,"-",0.38,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE21!I18","v":0}]
[null,17,17,"F","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",91,1,9,42,34,20,13,9,6,4,2,1,0,17,"F",0.19,"-",0.4,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE21!I19","v":0}]
[null,18,18,"D","L","H",7,0,0,0,0,0,8,0,1,"b","b","b","b",88,2,12,20,20,19,20,20,19,18,15,11,8,18,"D",0.23,"-",0.6,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE21!I20","v":68}]
[null,19,19,"E","L","H",4,0,139,0,72,3,7,0,2,"b","e","b","e",74,3,26,5,5,6,9,12,16,21,25,27,26,19,"E",0.3,"-",0.59,"D",0.55,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE21!I21","v":0}]
[null,20,20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",57,4,42,6,8,12,19,23,27,26,21,14,9,20,"Q",0.3,"-",0.6,"D",0.49,"-",0.33,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE21!I22","v":0}]
[null,21,21,"L","L","L",6,0,0,0,0,2,1,0,7,"b","b","b","b",17,5,78,30,29,27,23,18,13,8,4,3,2,21,"L",0.33,"-",0.58,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE21!I23","v":3}]
[null,22,22,"P","L","L",6,0,57,0,42,1,1,0,7,"b","e","b","e",16,5,80,12,12,12,14,17,21,24,24,21,19,22,"P",0.39,"-",0.57,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE21!I24","v":19}]
[null,23,23,"I","L","L",5,0,33,0,20,1,1,1,6,"b","e","b","i",20,13,71,14,15,17,20,21,20,19,17,16,15,23,"I",0.41,"-",0.55,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE21!I25","v":-13},{"$nulls":12},"3. Disorder: 25 residues, predicted to be disordered in the full length protein, are predicted to be ordered in the protein produced by NF1delE21, while 5 residues are predicted to be disordered in the latter but not in neurofibromin. While most of those 25 residues are isolated single or pairs of residues, there exists one big cluster of 8 consecutive residues that are located in the CSRD at positions 796-803, adjacent to the deleted exon in NF1fl. All 8 predictions have medium reliability. This indicates a potential loss of flexibility in this region of the protein, possibly affecting function."]
[null,24,24,"K","L","L",4,0,114,0,56,1,2,1,6,"b","e","b","e",21,15,68,6,7,10,13,16,19,21,22,22,21,24,"K",0.4,"-",0.56,"D",0.57,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE21!I26","v":0}]
[null,25,25,"T","L","L",6,0,127,0,90,2,1,1,7,"b","e","b","e",13,12,76,9,8,9,11,13,17,20,23,26,27,25,"T",0.4,"-",0.56,"D",0.5,"-",0.388,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE21!I27","v":-25}]
[null,26,26,"G","L","L",7,0,10,0,12,0,0,0,8,"b","b","b","i",8,10,83,20,20,20,21,20,19,17,15,14,13,26,"G",0.4,"-",0.51,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE21!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,0,7,"b","e","b","e",12,9,79,12,12,13,16,18,20,22,22,22,21,27,"Q",0.44,"-",0.57,"D",0.76,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE21!I29","v":0}]
[null,28,28,"Q","L","L",4,0,83,0,42,1,2,1,6,"b","e","b","e",22,16,63,11,12,14,17,20,21,22,21,19,18,28,"Q",0.48,"-",0.61,"D",0.77,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE21!I30","v":0}]
[null,29,29,"N","L","L",3,0,65,0,42,0,2,1,6,"b","e","b","e",25,16,64,12,12,13,16,18,20,21,21,20,19,29,"N",0.4,"-",0.59,"D",0.66,"D",0.51,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE21!I31","v":0}]
[null,30,30,"T","L","L",3,0,28,0,20,0,2,1,5,"b","e","b","i",29,14,62,16,16,17,19,20,20,19,17,14,12,30,"T",0.38,"-",0.57,"D",0.66,"D",0.469,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE21!I32","v":0}]
[null,31,31,"H","L","L",2,0,55,0,30,0,3,1,5,"b","e","b","i",35,14,56,11,12,14,17,19,21,21,20,18,16,31,"H",0.35,"-",0.6,"D",0.76,"D",0.495,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE21!I33","v":22}]
[null,32,32,"T","L","L",0,0,42,0,30,0,4,1,4,"b","e","b","i",43,12,50,12,12,13,16,18,20,20,20,19,18,32,"T",0.29,"-",0.59,"D",0.7,"D",0.455,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE21!I34","v":17},{"$nulls":12},"4. Protein Binding: Deletion of E21 leads to 17 newly predicted potential protein binding sites (CSRD: three; GRD: two; Sec14&PH: two), while 18 potential binding sites, predicted in full length NF1, are now predicted to be lost (CSRD: two; GRD: three; Sec14&PH: one) - in addition to those in the deleted exon.   "]
[null,33,33,"K","L","H",0,0,86,0,42,1,4,1,4,"b","e","b","e",48,12,45,11,11,13,16,19,21,22,20,17,15,33,"K",0.34,"-",0.47,"D",0.68,"D",0.5,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE21!I35","v":0}]
[null,34,34,"V","L","H",1,0,42,0,30,1,5,1,3,"b","e","b","i",53,12,36,13,13,15,17,19,20,20,18,16,14,34,"V",0.26,"-",0.55,"D",0.79,"D",0.5,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE21!I36","v":-14}]
[null,35,35,"S","L","H",2,0,26,0,20,0,5,1,3,"b","e","b","i",57,12,32,19,18,17,19,21,21,20,17,13,10,35,"S",0.23,"-",0.49,"D",0.86,"D",0.408,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE21!I37","v":13}]
[null,36,36,"T","L","H",3,0,0,0,0,0,6,0,2,"b","b","b","b",64,9,29,24,23,21,21,19,17,14,11,8,7,36,"T",0.2,"-",0.51,"D",0.77,"D",0.394,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE21!I38","v":28}]
[null,37,37,"E","L","H",5,0,108,0,56,2,7,0,2,"b","e","b","e",72,8,22,6,7,9,12,16,19,23,24,22,19,37,"E",0.15,"-",0.55,"D",0.62,"D",0.39,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE21!I39","v":0}]
[null,38,38,"H","L","H",4,0,36,0,20,1,6,0,2,"b","e","b","i",69,9,24,17,17,18,20,22,22,20,16,11,8,38,"H",0.14,"-",0.47,"D",0.35,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE21!I40","v":0}]
[null,39,39,"N","L","H",4,0,0,0,0,4,6,0,2,"b","b","b","b",68,7,26,32,27,20,16,14,11,9,7,5,4,39,"N",0.12,"-",0.36,"-",0.47,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE21!I41","v":0}]
[null,40,40,"K","L","H",6,0,61,0,30,2,8,0,1,"b","e","b","i",82,4,16,13,14,16,20,23,25,23,18,12,8,40,"K",0.13,"-",0.41,"-",0.33,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G42-delE21!I42","v":0}]
[null,41,41,"E","L","H",6,0,81,0,42,1,8,0,1,"b","e","b","e",81,4,16,13,14,15,17,19,22,23,21,17,14,41,"E",0.15,"-",0.46,"-",0.36,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G43-delE21!I43","v":0}]
[null,42,42,"C","L","H",6,0,0,0,0,2,7,0,1,"b","b","b","b",79,10,13,28,26,23,21,18,14,10,6,3,2,42,"C",0.17,"-",0.32,"-",0.41,"-",0.28,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G44-delE21!I44","v":0}]
[null,43,43,"L","L","H",6,0,0,0,0,8,7,1,1,"b","b","b","b",77,14,13,42,34,20,13,10,7,5,3,2,1,43,"L",0.18,"-",0.28,"-",0.32,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G45-delE21!I45","v":0}]
[null,44,44,"I","L","H",5,0,0,0,0,3,7,1,1,"b","b","b","b",73,16,15,30,27,22,19,16,13,9,6,4,3,44,"I",0.11,"-",0.41,"-",0.4,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G46-delE21!I46","v":0}]
[null,45,45,"N","L","H",4,0,47,0,30,1,6,1,2,"b","e","b","i",70,13,22,15,15,16,19,21,22,20,17,12,9,45,"N",0.08,"-",0.41,"-",0.21,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G47-delE21!I47","v":0}]
[null,46,46,"I","L","H",3,0,0,0,0,5,6,1,2,"b","b","b","b",65,11,28,35,30,23,18,14,11,7,4,2,1,46,"I",0.08,"-",0.41,"-",0.2,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G48-delE21!I48","v":0}]
[null,47,47,"S","L","H",1,0,0,0,0,6,5,0,3,"b","b","b","b",56,9,39,36,30,21,16,13,10,7,5,4,3,47,"S",0.06,"-",0.42,"-",0.19,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G49-delE21!I49","v":0}]
[null,48,48,"K","L","H",3,0,61,0,30,1,6,0,3,"b","e","b","i",67,5,31,14,14,14,17,19,22,22,21,18,16,48,"K",0.07,"-",0.56,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G50-delE21!I50","v":25}]
[null,49,49,"Y","L","H",3,0,44,0,20,1,6,0,3,"b","e","b","i",64,5,34,17,17,19,22,23,22,19,15,12,10,49,"Y",0.1,"-",0.48,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G51-delE21!I51","v":-18}]
[null,50,50,"K","L","H",3,0,41,0,20,0,6,0,2,"b","e","b","i",67,5,30,20,19,19,20,21,20,18,14,10,7,50,"K",0.11,"-",0.46,"-",0.2,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G52-delE21!I52","v":0}]
[null,51,51,"F","L","H",6,0,0,0,0,4,7,0,1,"b","b","b","b",81,4,17,34,30,22,18,14,11,7,5,3,2,51,"F",0.12,"-",0.34,"-",0.26,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G53-delE21!I53","v":0}]
[null,52,52,"S","L","H",7,0,0,0,0,1,8,0,1,"b","b","b","b",87,3,12,24,22,19,19,18,17,15,12,8,6,52,"S",0.09,"-",0.34,"-",0.18,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G54-delE21!I54","v":0}]
[null,53,53,"L","L","H",8,0,0,0,0,3,8,0,0,"b","b","b","b",91,3,8,27,24,19,17,16,14,11,8,4,3,53,"L",0.13,"-",0.32,"-",0.15,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G55-delE21!I55","v":0}]
[null,54,54,"V","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",94,2,5,46,36,16,10,6,4,2,1,0,0,54,"V",0.09,"-",0.28,"-",0.18,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G56-delE21!I56","v":0}]
[null,55,55,"I","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,1,4,42,33,18,12,8,5,3,1,0,0,55,"I",0.06,"-",0.28,"-",0.13,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G57-delE21!I57","v":0}]
[null,56,56,"S","L","H",8,0,39,0,30,1,9,0,0,"b","e","b","i",94,0,5,16,16,17,20,22,23,20,14,8,4,56,"S",0.07,"-",0.36,"-",0.13,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G58-delE21!I58","v":-39}]
[null,57,57,"G","L","H",8,0,0,0,0,3,9,0,0,"b","b","b","b",92,1,7,28,25,20,18,17,14,10,6,3,2,57,"G",0.07,"-",0.3,"-",0.14,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G59-delE21!I59","v":0}]
[null,58,58,"L","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,0,3,48,36,14,7,4,3,1,0,0,0,58,"L",0.08,"-",0.28,"-",0.18,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G60-delE21!I60","v":0}]
[null,59,59,"T","L","H",9,0,0,0,0,1,9,0,0,"b","b","b","b",94,1,4,26,24,21,20,18,15,11,7,3,2,59,"T",0.09,"-",0.38,"-",0.18,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G61-delE21!I61","v":0}]
[null,60,60,"T","L","H",8,0,42,0,30,3,9,0,0,"b","e","b","i",92,2,7,10,10,13,16,20,23,23,19,12,7,60,"T",0.13,"-",0.43,"-",0.24,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G62-delE21!I62","v":0}]
[null,61,61,"I","L","H",8,0,0,0,0,3,9,0,0,"b","b","b","b",92,1,7,29,26,22,19,17,12,8,4,1,0,61,"I",0.15,"-",0.39,"-",0.24,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G63-delE21!I63","v":0}]
[null,62,62,"L","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",92,1,6,44,34,19,11,7,4,3,2,1,0,62,"L",0.17,"-",0.4,"-",0.19,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G64-delE21!I64","v":0}]
[null,63,63,"K","L","H",8,0,114,0,56,3,8,0,0,"b","e","b","e",90,2,9,5,6,7,10,15,21,26,28,21,16,63,"K",0.14,"-",0.53,"D",0.28,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G65-delE21!I65","v":0}]
[null,64,64,"N","L","H",6,0,47,0,30,2,7,0,1,"b","e","b","i",79,2,18,11,12,14,18,20,22,21,18,13,10,64,"N",0.2,"-",0.58,"D",0.21,"-",0.28,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G66-delE21!I66","v":0}]
[null,65,65,"V","L","H",3,0,0,0,0,2,6,0,2,"b","b","b","b",68,4,29,29,27,24,22,18,13,8,5,3,2,65,"V",0.26,"-",0.52,"D",0.16,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G67-delE21!I67","v":0}]
[null,66,66,"N","L","H",2,0,65,0,42,1,5,0,3,"b","e","b","e",63,5,39,15,14,14,16,17,19,21,21,19,17,66,"N",0.29,"-",0.56,"D",0.2,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G68-delE21!I68","v":0}]
[null,{"$f":"B68+1","v":67},67,"N","L","H",0,0,87,0,56,2,4,0,4,"b","e","b","e",51,6,50,5,6,9,13,16,20,23,25,23,21,67,"N",0.34,"-",0.65,"D",0.33,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G69-delE21!I69","v":0}]
[null,68,68,"M","L","L",1,0,78,0,42,0,3,0,5,"b","e","b","e",42,9,55,10,11,13,16,18,20,21,21,21,20,68,"M",0.35,"-",0.62,"D",0.24,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G70-delE21!I70","v":-22}]
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[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":9074}]
[{"$nulls":55},{"$f":"SUM(BD1:BD2820)-SUM(BD806:BD952)","v":3022}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},147,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":121},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":181},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":320},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":112},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":376},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.04530138524897042,"d":"5%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.14077124672407337,"d":"14%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":187},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":129},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":52},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":7},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":1},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":84},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":23},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":11},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":5},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":17}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":25},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":18}]

{"sheet":"delE25","index":7,"n_rows":2864,"n_cols":69,"rows_kept":1125,"cut":true,"merged":[[0,2,0,43],[7,68,10,118],[14,68,20,118],[24,68,29,118],[33,68,35,118],[1175,0,1572,0],[2822,54,2834,55]],"bounds":{"rows_first":500,"rows_last":125,"rows_between":500,"halvings":2}}
[null,null,"delE25"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE25)"]
[null,1,1,"M","L","L",9,0,169,0,90,3,0,0,9,"b","e","b","e",1,1,96,8,8,8,10,11,13,14,16,23,27,1,"M",0.31,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE25!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",8,8,86,7,7,8,11,14,17,19,20,25,27,2,"A",0.21,"-",0.86,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE25!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",7,0,76,0,72,1,1,0,8,"b","e","b","e",12,8,82,7,8,9,13,16,20,22,23,24,24,3,"A",0.09,"-",0.83,"D",0.36,"-",0.556,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE25!I5","v":0},{"$nulls":12},"SUMMARY:"]
[null,4,4,"H","L","L",5,0,132,0,72,2,1,1,6,"b","e","b","e",20,11,72,6,7,8,12,15,18,22,24,26,26,4,"H",0.12,"-",0.84,"D",0.29,"-",0.5,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE25!I6","v":0}]
[null,5,5,"R","L","L",5,0,104,0,42,1,1,1,7,"b","e","b","e",17,11,75,8,9,12,16,20,23,24,23,21,18,5,"R",0.1,"-",0.7,"D",0.34,"-",0.455,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE25!I7","v":0}]
[null,6,6,"P","L","L",2,0,40,0,30,2,3,0,5,"b","e","b","i",38,7,61,14,14,15,18,21,23,22,19,15,12,6,"P",0.08,"-",0.64,"D",0.34,"-",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE25!I8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (4%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of full length neurofibromin. While the majority of predicted changes in secondary structure has very low or low reliability (RI_S = 0-3), 3 predicted changes in residue secondary structure have medium relibility (RI_S = 4-5). "]
[null,7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",68,4,35,14,15,16,20,21,21,18,16,12,10,7,"V",0.21,"-",0.58,"D",0.28,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE25!I9","v":0}]
[null,8,8,"E","L","H",6,0,81,0,42,2,7,0,1,"b","e","b","e",79,6,18,9,10,11,14,17,20,23,23,19,16,8,"E",0.25,"-",0.55,"D",0.23,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE25!I10","v":27}]
[null,9,9,"W","L","H",8,0,0,0,0,2,8,0,0,"b","b","b","b",88,4,8,30,28,24,23,20,15,10,5,2,1,9,"W",0.22,"-",0.4,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE25!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,7,9,0,0,"b","b","b","b",91,4,6,40,33,19,14,10,7,4,2,1,0,10,"V",0.12,"-",0.32,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE25!I12","v":0}]
[null,11,11,"Q","L","H",8,0,0,0,0,1,9,0,0,"b","b","b","b",93,2,5,24,22,19,19,18,17,14,11,6,4,11,"Q",0.1,"-",0.28,"-",0.18,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE25!I13","v":59}]
[null,12,12,"A","L","H",8,0,0,0,0,1,9,0,0,"b","b","b","b",93,2,5,26,24,21,20,19,17,13,8,4,2,12,"A",0.12,"-",0.26,"-",0.25,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE25!I14","v":0}]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,1,3,47,35,16,9,6,4,2,1,0,0,13,"V",0.12,"-",0.26,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE25!I15","v":0},{"$nulls":12},"2. Solvent Accessibility: 326 residues (12%) are predicted to have changed their classification (according to Pbie or Pbe, with b=burried, i=intermediate, e=exposed). Almost all predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-3). NF1delE25 may have a solvent accessibility that is further reduced, beyond what is attributed to the deleted exon."]
[null,14,14,"V","L","H",9,0,0,0,0,6,9,0,0,"b","b","b","b",95,1,3,36,30,20,16,12,9,6,3,1,1,14,"V",0.13,"-",0.33,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE25!I16","v":0}]
[null,15,15,"S","L","H",8,0,39,0,30,2,9,0,0,"b","e","b","i",92,1,6,12,12,14,18,21,23,22,18,11,7,15,"S",0.14,"-",0.42,"-",0.33,"-",0.364,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE25!I17","v":15}]
[null,16,16,"R","L","H",8,0,29,0,12,3,9,0,0,"b","b","b","i",91,2,8,15,18,23,27,27,23,16,9,4,1,16,"R",0.14,"-",0.38,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE25!I18","v":0}]
[null,17,17,"F","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",91,1,8,43,34,20,13,9,6,4,2,1,0,17,"F",0.18,"-",0.39,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE25!I19","v":0}]
[null,18,18,"D","L","H",7,0,0,0,0,0,8,0,1,"b","b","b","b",89,2,11,20,20,19,20,20,19,18,15,11,8,18,"D",0.22,"-",0.59,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE25!I20","v":68}]
[null,19,19,"E","L","H",4,0,108,0,56,4,7,0,2,"b","e","b","e",74,3,26,5,5,7,9,12,16,21,26,26,26,19,"E",0.29,"-",0.59,"D",0.55,"-",0.34,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE25!I21","v":31}]
[null,20,20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",56,4,44,6,8,13,19,23,26,25,21,14,9,20,"Q",0.31,"-",0.6,"D",0.49,"-",0.33,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE25!I22","v":0}]
[null,21,21,"L","L","L",6,0,0,0,0,1,1,0,8,"b","b","b","b",14,5,82,28,28,27,24,19,14,8,5,3,2,21,"L",0.35,"-",0.59,"D",0.5,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE25!I23","v":3}]
[null,22,22,"P","L","L",7,0,76,0,56,2,1,0,8,"b","e","b","e",12,6,83,13,12,12,13,16,21,24,25,22,19,22,"P",0.38,"-",0.57,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE25!I24","v":0}]
[null,23,23,"I","L","L",5,0,20,0,12,2,1,1,7,"b","b","b","i",17,12,74,17,19,22,24,21,18,14,12,12,11,23,"I",0.39,"-",0.55,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE25!I25","v":0},{"$nulls":12},"3. Disorder: 23 residues, predicted to be disordered in the full length protein, are predicted to be ordered in the protein produced by NF1delE25, while 2 residues are predicted to be disordered in the latter but not in neurofibromin. While most of those 23 residues are isolated single or pairs of residues, there exists one big cluster of 11 residues that are located in the CSRD at positions 801-813 in NF1fl. While this could in principle indicate a potential loss of flexibility in this region of the protein - possibly affecting function -, the prediction reliability for all residues is very low, which limits the interpretability of these results."]
[null,24,24,"K","L","L",5,0,114,0,56,3,1,1,6,"b","e","b","e",19,13,71,4,5,7,10,14,18,23,26,26,25,24,"K",0.41,"-",0.57,"D",0.57,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE25!I26","v":0}]
[null,25,25,"T","L","L",6,0,127,0,90,2,1,0,7,"b","e","b","e",15,10,77,9,9,9,11,14,17,20,23,26,27,25,"T",0.4,"-",0.56,"D",0.5,"-",0.394,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE25!I27","v":-25}]
[null,26,26,"G","L","L",7,0,10,0,12,0,0,1,7,"b","b","b","i",10,11,82,19,19,20,21,20,19,18,16,15,14,26,"G",0.41,"-",0.51,"D",0.66,"D",0.455,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE25!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,0,7,"b","e","b","e",12,9,80,12,12,14,17,19,21,22,22,21,20,27,"Q",0.45,"-",0.58,"D",0.76,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE25!I29","v":0}]
[null,28,28,"Q","L","L",4,0,83,0,42,0,2,1,6,"b","e","b","e",21,16,65,10,11,13,16,18,20,21,21,21,19,28,"Q",0.49,"-",0.64,"D",0.77,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE25!I30","v":0}]
[null,29,29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",26,17,63,12,12,13,16,18,20,21,21,20,19,29,"N",0.39,"-",0.61,"D",0.66,"D",0.51,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE25!I31","v":0}]
[null,30,30,"T","L","L",3,0,28,0,20,0,2,1,5,"b","e","b","i",29,15,61,16,16,17,19,20,20,19,17,14,12,30,"T",0.38,"-",0.58,"D",0.66,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE25!I32","v":0}]
[null,31,31,"H","L","L",2,0,55,0,30,0,3,1,5,"b","e","b","i",33,14,57,11,12,13,16,19,21,21,20,18,16,31,"H",0.34,"-",0.62,"D",0.76,"D",0.495,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE25!I33","v":22}]
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[null,2795,2756,"G","L","L",4,0,0,0,0,0,1,2,6,"b","b","b","b",21,22,65,22,22,21,22,20,19,16,13,11,10,2756,"G",0.63,"D",0.45,"-",0.73,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2797-delE25!I2797","v":10}]
[null,2796,2757,"S","L","L",3,0,0,0,0,0,2,1,5,"b","b","b","b",27,20,63,21,20,19,20,20,19,18,16,14,13,2757,"S",0.62,"D",0.43,"-",0.83,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2798-delE25!I2798","v":0}]
[null,2797,2758,"A","L","L",2,0,0,0,0,1,3,1,5,"b","b","b","b",39,15,60,24,22,20,20,19,18,15,13,12,11,2758,"A",0.68,"D",0.39,"-",0.87,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2799-delE25!I2799","v":0}]
[null,2798,2759,"S","L","L",1,0,26,0,20,0,3,1,5,"b","e","b","i",41,15,57,15,15,16,18,20,20,20,20,20,19,2759,"S",0.64,"D",0.47,"D",0.87,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2800-delE25!I2800","v":13}]
[null,2799,2760,"Q","L","L",2,0,83,0,42,0,3,1,5,"b","e","b","e",38,16,59,9,10,12,16,20,22,23,22,21,20,2760,"Q",0.69,"D",0.59,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE25!I2801","v":0}]
[null,2800,2761,"V","L","L",3,0,17,0,12,0,2,1,6,"b","b","b","i",27,15,66,18,18,19,21,21,19,17,15,14,13,2761,"V",0.7,"D",0.66,"D",0.91,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE25!I2802","v":11}]
[null,2801,2762,"Q","L","L",4,0,142,0,72,0,2,1,6,"b","e","b","e",23,16,69,10,11,12,15,18,20,22,22,23,22,2762,"Q",0.68,"D",0.69,"D",0.88,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE25!I2803","v":-59}]
[null,2802,2763,"K","L","L",5,0,147,0,72,1,1,1,7,"b","e","b","e",19,11,75,8,9,11,14,16,19,22,23,25,25,2763,"K",0.63,"D",0.74,"D",0.9,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE25!I2804","v":0}]
[null,2803,2764,"Q","L","L",5,0,83,0,42,0,1,1,7,"b","e","b","e",17,13,75,8,9,11,15,18,21,22,22,22,21,2764,"Q",0.58,"D",0.7,"D",0.79,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE25!I2805","v":27}]
[null,2804,2765,"R","L","L",5,0,104,0,42,0,1,1,7,"b","e","b","e",16,14,74,10,11,13,17,19,21,22,22,22,21,2765,"R",0.54,"D",0.7,"D",0.87,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE25!I2806","v":34}]
[null,2805,2766,"S","L","L",6,0,39,0,30,0,1,1,7,"b","e","b","i",16,14,76,11,12,14,18,21,22,21,20,19,18,2766,"S",0.57,"D",0.66,"D",0.93,"D",0.677,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE25!I2807","v":-13}]
[null,2806,2767,"A","L","L",5,0,44,0,42,0,1,1,6,"b","e","b","e",20,16,70,12,12,14,17,18,20,21,21,21,20,2767,"A",0.58,"D",0.61,"D",0.92,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE25!I2808","v":-13}]
[null,2807,2768,"G","L","L",5,0,10,0,12,0,1,1,6,"b","b","b","i",17,16,71,19,19,20,21,21,19,17,15,14,14,2768,"G",0.58,"D",0.51,"D",0.85,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE25!I2809","v":15}]
[null,2808,2769,"S","L","L",4,0,54,0,42,1,2,1,6,"b","e","b","e",22,18,68,15,15,15,17,19,21,22,22,20,18,2769,"S",0.62,"D",0.53,"D",0.73,"D",0.663,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE25!I2810","v":-54}]
[null,2809,2770,"F","L","L",3,0,23,0,12,0,2,2,5,"b","b","b","i",26,25,58,20,21,22,23,21,19,15,13,12,11,2770,"F",0.7,"D",0.62,"D",0.83,"D",0.663,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE25!I2811","v":-23}]
[null,2810,2771,"K","L","L",3,0,86,0,42,1,2,2,5,"b","e","b","e",24,22,60,7,8,9,13,17,21,24,24,21,19,2771,"K",0.62,"D",0.63,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE25!I2812","v":0}]
[null,2811,2772,"R","L","L",0,0,104,0,42,1,4,1,4,"b","e","b","e",42,14,48,6,7,10,14,18,22,24,24,21,18,2772,"R",0.67,"D",0.64,"D",0.86,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE25!I2813","v":-30}]
[null,2812,2773,"N","L","L",0,0,113,0,72,2,4,0,4,"b","e","b","e",48,8,51,4,5,7,10,14,18,22,25,26,26,2773,"N",0.36,"-",0.74,"D",0.83,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE25!I2814","v":0}]
[null,2813,2774,"S","L","L",0,0,72,0,56,1,4,0,4,"b","e","b","e",53,10,46,11,11,13,16,18,20,21,22,21,20,2774,"S",0.28,"-",0.69,"D",0.8,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE25!I2815","v":0}]
[null,2814,2775,"I","L","L",0,0,70,0,42,0,4,0,4,"b","e","b","e",53,10,48,11,12,13,16,19,20,21,20,20,18,2775,"I",0.44,"-",0.66,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE25!I2816","v":-20}]
[null,2815,2776,"K","L","L",2,0,147,0,72,2,3,1,5,"b","e","b","e",37,16,58,4,4,7,10,14,18,23,26,27,26,2776,"K",0.34,"-",0.81,"D",0.81,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE25!I2817","v":0}]
[null,2816,2777,"K","L","L",3,0,184,0,90,1,2,1,5,"b","e","b","e",31,22,62,4,4,7,9,14,18,22,25,27,28,2777,"K",0.39,"-",0.81,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE25!I2818","v":-37}]
[null,2817,2778,"I","L","L",5,0,50,0,30,0,1,1,6,"b","e","b","i",17,18,72,8,9,11,15,18,19,19,18,19,19,2778,"I",0.35,"-",0.82,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE25!I2819","v":-30}]
[null,2818,2779,"V","L","L",8,0,127,0,90,4,0,0,9,"b","e","b","e",3,6,92,8,8,7,9,11,12,14,16,25,28,2779,"V",0.31,"-",0.87,"D",0.74,"D",0.541,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE25!I2820","v":0}]
[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":4835}]
[{"$nulls":55},{"$f":"SUM(BD2:BD2820)-SUM(BD1069:BD1107)","v":3377}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},39,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":100},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":133},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":272},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":67},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":326},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.035984166966534725,"d":"4%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.11730838431090321,"d":"12%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":168},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":120},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":35},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":3},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":68},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":22},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":4},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":2},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":2},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":8}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":23},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":17}]

{"sheet":"delE28","index":8,"n_rows":2864,"n_cols":69,"rows_kept":1125,"cut":true,"merged":[[0,2,0,43],[7,68,12,118],[16,68,27,118],[31,68,35,118],[39,68,43,118],[1175,0,1572,0],[1238,2,1291,43],[2822,54,2834,55]],"bounds":{"rows_first":500,"rows_last":125,"rows_between":500,"halvings":2}}
[null,null,"delE28"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE28)"]
[null,1,1,"M","L","L",9,0,169,0,90,4,0,0,9,"b","e","b","e",1,1,96,8,8,8,9,11,13,14,16,24,28,1,"M",0.31,"-",0.99,"D",0.41,"-",0.592,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE28!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",9,7,86,6,6,7,10,13,16,19,21,26,28,2,"A",0.22,"-",0.85,"D",0.54,"-",0.576,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE28!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",7,0,76,0,72,1,1,0,8,"b","e","b","e",13,7,83,7,8,9,13,16,20,22,23,25,24,3,"A",0.1,"-",0.84,"D",0.36,"-",0.545,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G5-delE28!I5","v":0},{"$nulls":12},"SUMMARY: "]
[null,4,4,"H","L","L",5,0,132,0,72,2,1,1,7,"b","e","b","e",20,11,73,7,8,10,13,16,19,22,24,26,25,4,"H",0.12,"-",0.84,"D",0.29,"-",0.495,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE28!I6","v":0}]
[null,5,5,"R","L","L",6,0,104,0,42,3,1,0,7,"b","e","b","e",16,10,77,6,7,10,15,21,25,27,24,20,16,5,"R",0.1,"-",0.7,"D",0.34,"-",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE28!I7","v":0}]
[null,6,6,"P","L","L",1,0,40,0,30,1,4,0,5,"b","e","b","i",42,5,57,16,16,17,19,21,22,21,18,15,13,6,"P",0.09,"-",0.63,"D",0.34,"-",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE28!I8","v":0},{"$nulls":12},"1. Secondary Structure: A small percentage of residues (4%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of neurofibromin. While many predicted changes in secondary structure have very low or low reliability (RI_S = 0-3), 7 predicted changes have medium reliabilty (RI_S = 4-5), 3 have high reliability (RI_S = 6-7), and 8 have very high relibility (RI_S = 8). Out of those 8, 7 are in the GRD while one is within the extended Nex-GRDmin-Cex region. We hypothesize that this has a direct negative impact on Ras/Spred1 binding."]
[null,7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",68,4,35,14,15,16,19,20,20,18,16,12,10,7,"V",0.21,"-",0.62,"D",0.28,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE28!I9","v":0}]
[null,8,8,"E","L","H",6,0,81,0,42,2,7,0,1,"b","e","b","e",81,7,16,11,11,13,15,18,21,23,22,18,15,8,"E",0.26,"-",0.54,"D",0.23,"-",0.31,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE28!I10","v":27}]
[null,9,9,"W","L","H",7,0,0,0,0,2,8,0,0,"b","b","b","b",88,5,9,31,29,25,23,19,14,9,5,2,1,9,"W",0.21,"-",0.39,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE28!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,8,8,0,0,"b","b","b","b",91,4,7,41,33,19,14,10,7,4,2,1,0,10,"V",0.12,"-",0.3,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE28!I12","v":0}]
[null,11,11,"Q","L","H",8,0,0,0,0,1,9,0,0,"b","b","b","b",93,2,5,23,21,18,18,17,17,14,11,6,4,11,"Q",0.09,"-",0.27,"-",0.18,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE28!I13","v":59}]
[null,12,12,"A","L","H",8,0,0,0,0,1,9,0,0,"b","b","b","b",93,1,5,26,24,20,20,19,17,13,8,4,2,12,"A",0.13,"-",0.26,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE28!I14","v":0}]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,1,4,47,35,16,9,6,4,2,1,0,0,13,"V",0.12,"-",0.24,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE28!I15","v":0}]
[null,14,14,"V","L","H",9,0,0,0,0,6,9,0,0,"b","b","b","b",95,1,3,36,30,19,15,11,8,5,3,1,0,14,"V",0.13,"-",0.32,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE28!I16","v":0}]
[null,15,15,"S","L","H",8,0,39,0,30,2,9,0,0,"b","e","b","i",91,2,7,12,12,14,18,21,23,22,18,11,7,15,"S",0.15,"-",0.42,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE28!I17","v":15},{"$nulls":12},"2. Solvent Accessibility: 246 residues (9%) are predicted to have changed its classification (according to Pbie/Pbe; b=burried, i=intermediate, e=exposed). Most predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-3), but five have medium reliability (RI_A = 4-5). Three of those are found in the GRD, one is right outside the GRD, and another is  in the Tubulin binding domain. NF1delE28's overall solvent accessibility is probably slightly reduced, in addition to the lost solvent accessibility attributed to the deleted exon. "]
[null,16,16,"R","L","H",8,0,29,0,12,3,8,0,0,"b","b","b","i",90,2,10,15,18,23,27,26,23,16,9,4,2,16,"R",0.15,"-",0.38,"-",0.33,"-",0.35,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE28!I18","v":0}]
[null,17,17,"F","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",91,1,9,42,33,20,13,9,6,4,2,1,0,17,"F",0.2,"-",0.4,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE28!I19","v":0}]
[null,18,18,"D","L","H",7,0,19,0,12,0,8,0,1,"b","b","b","i",89,2,11,19,19,19,20,20,19,18,15,12,9,18,"D",0.24,"-",0.6,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE28!I20","v":49}]
[null,19,19,"E","L","H",4,0,139,0,72,3,7,0,2,"b","e","b","e",73,3,27,5,6,7,9,12,16,21,25,26,25,19,"E",0.3,"-",0.59,"D",0.55,"-",0.34,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE28!I21","v":0}]
[null,20,20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",55,4,44,7,9,13,19,23,26,25,21,14,9,20,"Q",0.31,"-",0.6,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE28!I22","v":0}]
[null,21,21,"L","L","L",6,0,0,0,0,0,1,0,8,"b","b","b","b",14,5,82,27,27,27,24,19,14,8,5,3,2,21,"L",0.34,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE28!I23","v":3}]
[null,22,22,"P","L","L",7,0,76,0,56,2,1,0,8,"b","e","b","e",12,6,83,12,11,11,13,16,20,24,25,23,20,22,"P",0.38,"-",0.58,"D",0.71,"D",0.32,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE28!I24","v":0}]
[null,23,23,"I","L","L",5,0,20,0,12,2,1,1,7,"b","b","b","i",18,12,73,17,20,23,24,22,18,14,12,11,11,23,"I",0.38,"-",0.55,"D",0.66,"D",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE28!I25","v":0}]
[null,24,24,"K","L","L",5,0,114,0,56,3,1,1,6,"b","e","b","e",20,14,71,4,5,7,10,14,18,23,26,26,25,24,"K",0.39,"-",0.57,"D",0.57,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE28!I26","v":0}]
[null,25,25,"T","L","L",6,0,127,0,90,2,1,1,7,"b","e","b","e",14,11,77,9,9,9,11,14,17,20,23,26,27,25,"T",0.4,"-",0.56,"D",0.5,"-",0.384,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE28!I27","v":-25}]
[null,26,26,"G","L","L",7,0,10,0,12,0,0,1,7,"b","b","b","i",10,11,82,19,19,20,21,20,19,18,16,15,14,26,"G",0.4,"-",0.51,"D",0.66,"D",0.439,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE28!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,0,7,"b","e","b","e",12,9,79,11,11,13,16,18,21,22,22,22,21,27,"Q",0.45,"-",0.59,"D",0.76,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE28!I29","v":0}]
[null,28,28,"Q","L","L",4,0,110,0,56,1,2,1,6,"b","e","b","e",22,15,64,10,11,13,16,18,20,21,22,21,20,28,"Q",0.52,"D",0.64,"D",0.77,"D",0.51,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE28!I30","v":-27}]
[null,29,29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",27,16,62,12,12,13,16,18,20,21,21,20,19,29,"N",0.41,"-",0.6,"D",0.66,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE28!I31","v":0}]
[null,30,30,"T","L","L",3,0,28,0,20,0,2,1,5,"b","e","b","i",31,14,61,16,16,17,19,20,20,19,17,15,13,30,"T",0.39,"-",0.57,"D",0.66,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE28!I32","v":0},{"$nulls":12},"3. Disorder: 11 residues, predicted to be disordered in the full length protein are predicted to not be disordered in the protein produced by NF1delE28. Out of those, 4 are in a 6 residue long sequence at positions 29-34. 11 residues are predicted to be disordered in NF1delE28 but not in neurofibromin. All such predicted disordered residues are in one long sequence (positions 1120-1130 in NF1fl). This suggests a potential gain of flexibility in one part and a potential loss of flexibility in another. However, all predictions have very low to low reliability."]
[null,31,31,"H","L","L",1,0,77,0,42,1,3,1,5,"b","e","b","e",37,14,55,11,12,14,17,18,20,21,20,18,16,31,"H",0.35,"-",0.6,"D",0.76,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE28!I33","v":0}]
[null,32,32,"T","L","L",1,0,42,0,30,0,3,1,4,"b","e","b","i",42,12,52,12,12,13,16,18,20,20,20,19,18,32,"T",0.27,"-",0.58,"D",0.7,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE28!I34","v":17}]
[null,33,33,"K","L","H",0,0,86,0,42,1,4,1,4,"b","e","b","e",49,12,45,8,9,10,13,16,20,22,22,20,18,33,"K",0.34,"-",0.46,"-",0.68,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE28!I35","v":0}]
[null,34,34,"V","L","H",2,0,28,0,20,0,5,0,3,"b","e","b","i",57,10,37,14,14,15,18,20,20,20,18,16,14,34,"V",0.27,"-",0.56,"D",0.79,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE28!I36","v":0}]
[null,35,35,"S","L","H",2,0,39,0,30,0,5,0,3,"b","e","b","i",61,9,34,18,17,16,18,19,20,19,17,14,11,35,"S",0.23,"-",0.51,"D",0.86,"D",0.429,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE28!I37","v":0}]
[null,36,36,"T","L","H",3,0,28,0,20,0,6,0,2,"b","e","b","i",67,6,29,19,19,19,20,21,21,19,15,11,8,36,"T",0.19,"-",0.54,"D",0.77,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE28!I38","v":0}]
[null,37,37,"E","L","H",5,0,108,0,56,3,7,0,2,"b","e","b","e",74,6,22,5,5,7,10,14,18,23,25,24,22,37,"E",0.15,"-",0.57,"D",0.62,"D",0.404,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE28!I39","v":0}]
[null,38,38,"H","L","H",4,0,36,0,20,1,6,0,2,"b","e","b","i",72,8,23,17,17,18,20,22,22,20,15,11,8,38,"H",0.14,"-",0.48,"D",0.35,"-",0.3,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE28!I40","v":0},{"$nulls":12},"4. Protein Binding: Deletion of E28 (part of the GRD) leads to 4 newly predicted potential protein binding sites (CSRD: two; GRD: one), while 15 potential binding sites, predicted in full length NF1, are now predicted to be lost in the protein NF1del28 (CSRD: two; GRD: two) - in addition to those in the deleted exon."]
[null,39,39,"N","L","H",4,0,0,0,0,4,7,0,2,"b","b","b","b",73,6,25,31,27,20,17,15,12,10,8,5,4,39,"N",0.13,"-",0.38,"-",0.47,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE28!I41","v":0}]
[null,40,40,"K","L","H",7,0,61,0,30,2,8,0,1,"b","e","b","i",84,4,14,12,13,15,19,22,24,23,19,13,9,40,"K",0.15,"-",0.41,"-",0.33,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G42-delE28!I42","v":0}]
[null,41,41,"E","L","H",7,0,81,0,42,2,8,0,1,"b","e","b","e",84,4,14,12,13,14,16,19,22,23,22,18,15,41,"E",0.17,"-",0.47,"D",0.36,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G43-delE28!I43","v":0}]
[null,42,42,"C","L","H",6,0,0,0,0,3,7,0,1,"b","b","b","b",80,10,13,30,27,22,19,17,13,9,6,3,2,42,"C",0.2,"-",0.3,"-",0.41,"-",0.28,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G44-delE28!I44","v":0}]
[null,43,43,"L","L","H",6,0,0,0,0,8,7,1,1,"b","b","b","b",75,15,14,42,33,20,13,10,7,5,3,2,1,43,"L",0.21,"-",0.28,"-",0.32,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G45-delE28!I45","v":0}]
[null,44,44,"I","L","H",5,0,0,0,0,3,6,1,1,"b","b","b","b",69,17,17,31,28,23,19,16,12,9,6,4,3,44,"I",0.12,"-",0.41,"-",0.4,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G46-delE28!I46","v":0}]
[null,45,45,"N","L","H",4,0,47,0,30,1,6,1,2,"b","e","b","i",68,13,23,15,15,16,19,21,22,20,17,12,9,45,"N",0.08,"-",0.4,"-",0.21,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G47-delE28!I47","v":0}]
[null,46,46,"I","L","H",3,0,0,0,0,5,6,0,2,"b","b","b","b",65,10,29,35,30,23,18,14,10,7,4,2,1,46,"I",0.08,"-",0.42,"-",0.2,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G48-delE28!I48","v":0}]
[null,47,47,"S","L","H",1,0,0,0,0,5,5,0,4,"b","b","b","b",53,7,42,35,30,21,17,14,11,8,6,4,3,47,"S",0.06,"-",0.45,"-",0.19,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G49-delE28!I49","v":0}]
[null,48,48,"K","L","H",2,0,86,0,42,1,6,0,3,"b","e","b","e",64,4,36,13,13,13,15,18,21,22,22,20,18,48,"K",0.08,"-",0.59,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G50-delE28!I50","v":0}]
[null,49,49,"Y","L","H",1,0,44,0,20,1,5,0,4,"b","e","b","i",54,5,43,17,18,20,22,23,22,18,14,11,9,49,"Y",0.09,"-",0.52,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G51-delE28!I51","v":-18}]
[null,50,50,"K","L","H",1,0,41,0,20,0,5,0,3,"b","e","b","i",58,6,39,19,18,18,20,21,21,18,14,10,7,50,"K",0.11,"-",0.48,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G52-delE28!I52","v":0}]
[null,51,51,"F","L","H",5,0,0,0,0,5,7,0,2,"b","b","b","b",74,4,24,35,31,23,18,14,11,7,5,3,2,51,"F",0.13,"-",0.35,"-",0.26,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G53-delE28!I53","v":0}]
[null,52,52,"S","L","H",6,0,0,0,0,1,8,0,1,"b","b","b","b",85,3,16,25,23,19,19,18,16,13,10,7,5,52,"S",0.1,"-",0.34,"-",0.18,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G54-delE28!I54","v":0}]
[null,53,53,"L","L","H",8,0,0,0,0,4,8,0,0,"b","b","b","b",91,3,8,32,28,20,16,14,11,8,5,3,2,53,"L",0.15,"-",0.29,"-",0.15,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G55-delE28!I55","v":0}]
[null,54,54,"V","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",94,3,5,45,35,17,11,7,4,2,1,0,0,54,"V",0.1,"-",0.27,"-",0.18,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G56-delE28!I56","v":0}]
[null,55,55,"I","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,2,4,43,34,16,10,7,4,2,1,0,0,55,"I",0.07,"-",0.26,"-",0.13,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G57-delE28!I57","v":0}]
[null,56,56,"S","L","H",8,0,0,0,0,2,9,0,0,"b","b","b","b",94,1,5,27,24,20,18,17,15,11,8,4,3,56,"S",0.08,"-",0.33,"-",0.13,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G58-delE28!I58","v":0}]
[null,57,57,"G","L","H",8,0,0,0,0,5,9,0,0,"b","b","b","b",93,1,6,34,28,18,15,12,10,7,4,2,1,57,"G",0.08,"-",0.25,"-",0.14,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G59-delE28!I59","v":0}]
[null,58,58,"L","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",96,0,3,48,36,15,8,5,3,1,0,0,0,58,"L",0.09,"-",0.26,"-",0.18,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G60-delE28!I60","v":0}]
[null,59,59,"T","L","H",9,0,0,0,0,3,9,0,0,"b","b","b","b",95,1,4,28,25,20,18,16,13,9,6,3,2,59,"T",0.1,"-",0.34,"-",0.18,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G61-delE28!I61","v":0}]
[null,60,60,"T","L","H",8,0,42,0,30,3,9,0,0,"b","e","b","i",92,1,7,11,12,14,18,21,24,23,18,10,6,60,"T",0.14,"-",0.41,"-",0.24,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G62-delE28!I62","v":0}]
[null,61,61,"I","L","H",8,0,0,0,0,3,9,0,0,"b","b","b","b",92,1,7,31,27,21,18,15,11,7,3,1,0,61,"I",0.17,"-",0.35,"-",0.24,"-",0.29,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G63-delE28!I63","v":0}]
[null,62,62,"L","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",93,1,5,44,34,18,11,7,4,3,2,1,0,62,"L",0.18,"-",0.38,"-",0.19,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G64-delE28!I64","v":0}]
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[null,2772,2718,"G","L","L",6,0,75,0,90,1,1,0,7,"b","e","b","e",17,10,77,11,11,12,14,16,18,20,22,23,24,2718,"G",0.72,"D",0.6,"D",0.8,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2774-delE28!I2774","v":-15}]
[null,2773,2719,"I","L","L",4,0,20,0,12,2,2,1,6,"b","b","b","i",24,13,68,17,19,22,24,22,19,14,11,10,9,2719,"I",0.72,"D",0.65,"D",0.83,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2775-delE28!I2775","v":0}]
[null,2774,2720,"D","L","L",4,0,91,0,56,2,2,1,6,"b","e","b","e",27,12,69,9,10,11,14,17,20,23,24,23,22,2720,"D",0.75,"D",0.69,"D",0.75,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2776-delE28!I2776","v":-23}]
[null,2775,2721,"K","L","L",3,0,147,0,72,1,2,1,6,"b","e","b","e",29,11,67,6,7,9,13,16,19,21,22,24,23,2721,"K",0.74,"D",0.71,"D",0.75,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2777-delE28!I2777","v":0}]
[null,2776,2722,"E","L","L",5,0,139,0,72,1,1,1,7,"b","e","b","e",19,11,74,7,8,10,13,15,19,21,23,24,24,2722,"E",0.74,"D",0.67,"D",0.75,"D",0.633,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2778-delE28!I2778","v":0}]
[null,2777,2723,"N","L","L",5,0,65,0,42,1,1,1,7,"b","e","b","e",16,12,74,9,10,13,16,19,21,22,22,20,18,2723,"N",0.67,"D",0.59,"D",0.77,"D",0.622,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2779-delE28!I2779","v":0}]
[null,2778,2724,"V","L","L",5,0,17,0,12,0,1,1,6,"b","b","b","i",18,14,73,16,16,17,20,20,20,18,16,14,13,2724,"V",0.68,"D",0.59,"D",0.86,"D",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2780-delE28!I2780","v":11}]
[null,2779,2725,"E","L","L",5,0,58,0,30,1,1,1,6,"b","e","b","i",19,17,70,12,13,16,19,21,22,22,20,17,15,2725,"E",0.63,"D",0.61,"D",0.79,"D",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2781-delE28!I2781","v":23}]
[null,2780,2726,"L","L","L",4,0,68,0,42,0,2,1,6,"b","e","b","e",21,15,69,14,14,14,16,18,19,20,20,20,20,2726,"L",0.65,"D",0.53,"D",0.64,"D",0.582,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2782-delE28!I2782","v":0}]
[null,2781,2727,"S","L","L",5,0,15,0,12,0,1,1,7,"b","b","b","i",13,17,75,21,21,21,22,21,19,17,14,11,10,2727,"S",0.66,"D",0.49,"D",0.44,"-",0.576,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2783-delE28!I2783","v":0}]
[null,2782,2728,"P","L","L",5,0,16,0,12,0,1,1,7,"b","b","b","i",14,16,75,20,20,20,21,20,20,18,17,15,13,2728,"P",0.63,"D",0.49,"D",0.44,"-",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2784-delE28!I2784","v":0}]
[null,2783,2729,"T","L","L",6,0,0,0,0,0,1,1,7,"b","b","b","b",11,14,78,22,22,20,21,20,19,17,15,12,10,2729,"T",0.61,"D",0.46,"-",0.54,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2785-delE28!I2785","v":0}]
[null,2784,2730,"T","L","L",5,0,0,0,0,0,1,1,7,"b","b","b","b",17,13,73,21,21,20,21,20,19,17,14,12,11,2730,"T",0.68,"D",0.49,"D",0.44,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2786-delE28!I2786","v":0}]
[null,2785,2731,"G","L","L",5,0,25,0,30,0,1,1,6,"b","e","b","i",20,14,71,14,14,15,17,19,21,21,21,20,19,2731,"G",0.69,"D",0.55,"D",0.6,"D",0.612,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2787-delE28!I2787","v":0}]
[null,2786,2732,"H","L","L",4,0,55,0,30,1,2,1,6,"b","e","b","i",24,17,65,13,14,16,19,21,22,21,19,17,16,2732,"H",0.71,"D",0.53,"D",0.57,"-",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2788-delE28!I2788","v":0}]
[null,2787,2733,"C","L","L",5,0,27,0,20,0,1,1,6,"b","e","b","i",20,13,72,15,15,17,19,20,20,19,17,17,16,2733,"C",0.71,"D",0.51,"D",0.57,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2789-delE28!I2789","v":0}]
[null,2788,2734,"N","L","L",6,0,141,0,90,1,1,0,7,"b","e","b","e",14,10,78,9,9,11,14,16,18,20,21,24,25,2734,"N",0.69,"D",0.47,"D",0.55,"-",0.602,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2790-delE28!I2790","v":0}]
[null,2789,2735,"S","L","L",6,0,72,0,56,0,1,1,7,"b","e","b","e",14,11,78,12,12,14,16,18,20,20,21,21,21,2735,"S",0.63,"D",0.53,"D",0.52,"-",0.606,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2791-delE28!I2791","v":21}]
[null,2790,2736,"G","L","L",6,0,16,0,20,0,1,1,7,"b","e","b","i",14,12,77,13,14,16,18,20,20,20,19,18,17,2736,"G",0.48,"-",0.43,"-",0.57,"-",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2792-delE28!I2792","v":9}]
[null,2791,2737,"R","L","L",5,0,49,0,20,1,1,1,6,"b","e","b","i",13,20,71,14,15,17,20,22,22,20,17,14,12,2737,"R",0.51,"-",0.53,"D",0.59,"D",0.602,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2793-delE28!I2793","v":0}]
[null,2792,2738,"T","L","L",5,0,28,0,20,0,1,1,6,"b","e","b","i",18,18,70,18,18,18,20,21,21,20,17,15,13,2738,"T",0.56,"D",0.53,"D",0.74,"D",0.622,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2794-delE28!I2794","v":0}]
[null,2793,2739,"R","L","L",4,0,29,0,12,0,1,1,6,"b","b","b","i",17,21,68,19,20,21,22,22,20,17,13,10,8,2739,"R",0.57,"D",0.44,"-",0.76,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2795-delE28!I2795","v":0}]
[null,2794,2740,"H","L","L",5,0,0,0,0,0,1,1,6,"b","b","b","b",16,20,71,22,21,21,21,20,18,16,13,11,10,2740,"H",0.61,"D",0.49,"D",0.66,"D",0.602,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2796-delE28!I2796","v":0}]
[null,2795,2741,"G","L","L",5,0,10,0,12,0,1,1,6,"b","b","b","i",19,16,73,21,21,21,22,21,20,18,15,12,10,2741,"G",0.62,"D",0.54,"D",0.73,"D",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2797-delE28!I2797","v":0}]
[null,2796,2742,"S","L","L",4,0,0,0,0,0,2,1,6,"b","b","b","b",26,14,68,22,21,19,20,20,19,18,15,13,11,2742,"S",0.67,"D",0.47,"D",0.83,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2798-delE28!I2798","v":0}]
[null,2797,2743,"A","L","L",0,0,0,0,0,0,4,0,4,"b","b","b","b",51,9,50,23,22,20,21,20,19,16,15,14,13,2743,"A",0.72,"D",0.41,"-",0.87,"D",0.616,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2799-delE28!I2799","v":0}]
[null,2798,2744,"S","L","L",0,0,72,0,56,1,4,0,4,"b","e","b","e",48,9,51,11,11,12,15,18,20,22,23,22,21,2744,"S",0.71,"D",0.58,"D",0.87,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2800-delE28!I2800","v":-33}]
[null,2799,2745,"Q","L","L",0,0,83,0,42,2,4,1,4,"b","e","b","e",45,11,51,9,11,13,17,21,23,24,22,19,17,2745,"Q",0.7,"D",0.65,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE28!I2801","v":0}]
[null,2800,2746,"V","L","L",2,0,17,0,12,0,3,1,5,"b","b","b","i",34,16,56,20,20,20,21,20,19,16,14,12,11,2746,"V",0.67,"D",0.62,"D",0.91,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE28!I2802","v":11}]
[null,2801,2747,"Q","L","L",3,0,83,0,42,1,2,1,5,"b","e","b","e",28,19,63,13,14,15,18,20,22,23,21,18,16,2747,"Q",0.69,"D",0.68,"D",0.88,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE28!I2803","v":0}]
[null,2802,2748,"K","L","L",4,0,114,0,56,3,2,1,6,"b","e","b","e",22,17,70,7,7,9,12,16,20,24,26,26,25,2748,"K",0.69,"D",0.7,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE28!I2804","v":33}]
[null,2803,2749,"Q","L","L",5,0,83,0,42,0,1,1,6,"b","e","b","e",17,16,75,7,8,11,15,19,22,23,23,22,21,2749,"Q",0.63,"D",0.61,"D",0.79,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE28!I2805","v":27}]
[null,2804,2750,"R","L","L",6,0,104,0,42,0,1,1,7,"b","e","b","e",16,13,78,10,11,13,16,19,21,22,22,22,21,2750,"R",0.66,"D",0.67,"D",0.87,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE28!I2806","v":34}]
[null,2805,2751,"S","L","L",6,0,39,0,30,1,1,1,7,"b","e","b","i",16,12,78,13,14,16,20,22,23,22,20,18,17,2751,"S",0.67,"D",0.62,"D",0.93,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE28!I2807","v":-13}]
[null,2806,2752,"A","L","L",5,0,76,0,72,1,2,0,7,"b","e","b","e",22,10,75,10,11,12,15,16,19,20,21,24,24,2752,"A",0.66,"D",0.65,"D",0.92,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE28!I2808","v":-45}]
[null,2807,2753,"G","L","L",4,0,10,0,12,0,2,1,6,"b","b","b","i",23,11,72,20,20,19,21,21,20,18,17,15,14,2753,"G",0.6,"D",0.56,"D",0.85,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE28!I2809","v":15}]
[null,2808,2754,"S","L","L",4,0,0,0,0,0,2,1,6,"b","b","b","b",26,13,70,20,20,19,20,20,20,19,18,17,15,2754,"S",0.59,"D",0.55,"D",0.73,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE28!I2810","v":0}]
[null,2809,2755,"F","L","L",2,0,0,0,0,0,3,2,5,"b","b","b","b",33,22,55,24,24,22,22,20,17,13,11,9,9,2755,"F",0.71,"D",0.62,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE28!I2811","v":0}]
[null,2810,2756,"K","L","L",2,0,86,0,42,1,2,1,5,"b","e","b","e",31,18,58,8,8,9,13,17,21,23,23,21,19,2756,"K",0.64,"D",0.58,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE28!I2812","v":0}]
[null,2811,2757,"R","L","L",0,0,74,0,30,1,4,1,4,"b","e","b","i",45,15,47,8,10,14,19,22,24,23,21,19,16,2757,"R",0.68,"D",0.61,"D",0.86,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE28!I2813","v":0}]
[null,2812,2758,"N","L","H",0,0,113,0,72,0,4,1,4,"b","e","b","e",50,12,50,7,8,10,14,17,20,22,22,23,22,2758,"N",0.37,"-",0.71,"D",0.83,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE28!I2814","v":0}]
[null,2813,2759,"S","L","H",2,0,72,0,56,1,5,1,3,"b","e","b","e",60,14,39,10,11,13,16,19,21,22,23,22,21,2759,"S",0.25,"-",0.58,"D",0.8,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE28!I2815","v":0}]
[null,2814,2760,"I","L","H",1,0,50,0,30,0,5,1,3,"b","e","b","i",57,16,41,13,13,14,16,18,20,20,20,20,20,2760,"I",0.4,"-",0.59,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE28!I2816","v":0}]
[null,2815,2761,"K","L","H",0,0,147,0,72,3,4,1,3,"b","e","b","e",48,21,44,3,3,6,9,14,18,23,27,28,28,2761,"K",0.32,"-",0.67,"D",0.81,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE28!I2817","v":0}]
[null,2816,2762,"K","L","L",2,0,147,0,72,2,2,2,4,"b","e","b","e",32,27,55,4,4,7,10,14,18,23,26,27,27,2762,"K",0.38,"-",0.79,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE28!I2818","v":0}]
[null,2817,2763,"I","L","L",3,0,121,0,72,0,1,2,5,"b","e","b","e",19,25,63,9,10,12,15,18,19,19,18,20,20,2763,"I",0.34,"-",0.77,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE28!I2819","v":-101}]
[null,2818,2764,"V","L","L",8,0,127,0,90,4,0,0,8,"b","e","b","e",3,8,91,4,4,5,7,9,12,16,19,28,32,2764,"V",0.38,"-",0.84,"D",0.74,"D",0.545,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE28!I2820","v":0}]
[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":3313}]
[{"$nulls":55},{"$f":"SUM(BD2:BD2820)-SUM(BD1239:BD1292)","v":2083}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},54,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":109},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":96},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":209},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":45},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":246},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.0394356005788712,"d":"4%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.08900144717800289,"d":"9%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":113},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":89},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":29},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":10},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":4},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":1},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":57},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":22},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":9},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":4},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":2},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":8},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":11},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":4}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":11},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":15}]

{"sheet":"delE36","index":9,"n_rows":2864,"n_cols":69,"rows_kept":1125,"cut":true,"merged":[[0,2,0,43],[7,68,10,118],[14,68,20,118],[24,68,29,118],[33,68,35,118],[1175,0,1572,0],[2822,54,2834,55]],"bounds":{"rows_first":500,"rows_last":125,"rows_between":500,"halvings":2}}
[null,null,"delE36"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE35)"]
[null,1,1,"M","L","L",9,0,169,0,90,4,0,0,9,"b","e","b","e",1,1,96,8,7,7,9,11,13,14,16,24,28,1,"M",0.31,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE36!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",9,7,86,6,6,7,10,13,16,19,21,26,28,2,"A",0.21,"-",0.86,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE36!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",7,0,76,0,72,1,1,0,8,"b","e","b","e",13,7,83,7,7,9,13,16,20,22,23,25,24,3,"A",0.1,"-",0.83,"D",0.36,"-",0.556,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G5-delE36!I5","v":0},{"$nulls":12},"SUMMARY: "]
[null,4,4,"H","L","L",5,0,132,0,72,2,1,1,7,"b","e","b","e",20,11,73,6,6,8,12,15,18,22,24,27,26,4,"H",0.11,"-",0.84,"D",0.29,"-",0.5,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE36!I6","v":0}]
[null,5,5,"R","L","L",6,0,104,0,42,3,1,0,7,"b","e","b","e",16,10,76,6,7,10,15,21,25,27,24,20,16,5,"R",0.1,"-",0.7,"D",0.34,"-",0.455,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE36!I7","v":0}]
[null,6,6,"P","L","L",1,0,40,0,30,1,4,0,5,"b","e","b","i",42,6,56,16,16,17,19,21,22,21,18,15,13,6,"P",0.08,"-",0.64,"D",0.34,"-",0.424,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE36!I8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (4%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of full length neurofibromin. All predicted changes in secondary structure have very low or low reliability (RI_S = 0-3)."]
[null,7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",69,4,32,13,14,16,19,20,20,19,16,13,10,7,"V",0.21,"-",0.6,"D",0.28,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE36!I9","v":0}]
[null,8,8,"E","L","H",6,0,81,0,42,2,7,0,1,"b","e","b","e",83,7,14,10,11,12,15,18,21,23,22,18,15,8,"E",0.25,"-",0.53,"D",0.23,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE36!I10","v":27}]
[null,9,9,"W","L","H",8,0,0,0,0,2,8,0,0,"b","b","b","b",89,4,8,31,29,25,22,19,14,9,5,2,1,9,"W",0.22,"-",0.4,"-",0.26,"-",0.32,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE36!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,7,8,0,0,"b","b","b","b",91,4,7,40,33,19,14,10,7,4,2,1,0,10,"V",0.13,"-",0.32,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE36!I12","v":0}]
[null,11,11,"Q","L","H",8,0,0,0,0,1,9,0,0,"b","b","b","b",93,2,5,23,21,18,18,17,17,14,11,6,4,11,"Q",0.1,"-",0.28,"-",0.18,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE36!I13","v":59}]
[null,12,12,"A","L","H",8,0,0,0,0,1,9,0,0,"b","b","b","b",93,1,5,26,24,20,20,19,17,13,8,4,2,12,"A",0.13,"-",0.27,"-",0.25,"-",0.33,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE36!I14","v":0}]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,1,3,47,36,16,9,6,4,2,1,0,0,13,"V",0.12,"-",0.25,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE36!I15","v":0},{"$nulls":12},"2. Solvent Accessibility: 346 residues (12%) are predicted to have changed their classification (according to Pbie or Pbe, with b=burried, i=intermediate, e=exposed). All predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-3). NF1delE35 could  have an overall solvent accessibility that is further reduced, beyond what is attributed to the deleted exon."]
[null,14,14,"V","L","H",9,0,0,0,0,6,9,0,0,"b","b","b","b",95,1,3,36,30,20,16,12,9,6,3,1,0,14,"V",0.13,"-",0.32,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE36!I16","v":0}]
[null,15,15,"S","L","H",8,0,39,0,30,3,9,0,0,"b","e","b","i",92,1,6,12,12,14,18,21,24,23,18,11,7,15,"S",0.14,"-",0.41,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE36!I17","v":15}]
[null,16,16,"R","L","H",8,0,29,0,12,3,8,0,0,"b","b","b","i",90,2,9,15,18,23,27,26,23,16,9,4,1,16,"R",0.14,"-",0.38,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE36!I18","v":0}]
[null,17,17,"F","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",91,1,8,42,34,20,13,9,6,4,2,1,0,17,"F",0.19,"-",0.4,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE36!I19","v":0}]
[null,18,18,"D","L","H",8,0,0,0,0,0,8,0,0,"b","b","b","b",90,2,10,20,20,19,20,20,19,18,15,11,8,18,"D",0.22,"-",0.6,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE36!I20","v":68}]
[null,19,19,"E","L","H",5,0,139,0,72,3,7,0,2,"b","e","b","e",75,3,25,6,6,7,9,12,16,22,26,27,26,19,"E",0.29,"-",0.59,"D",0.55,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE36!I21","v":0}]
[null,20,20,"Q","L","H",1,0,59,0,30,3,5,0,3,"b","e","b","i",59,4,41,6,8,12,18,22,26,25,21,15,10,20,"Q",0.3,"-",0.6,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE36!I22","v":0}]
[null,21,21,"L","L","L",6,0,0,0,0,0,1,0,7,"b","b","b","b",16,5,79,27,27,27,24,20,14,8,5,3,2,21,"L",0.33,"-",0.59,"D",0.5,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE36!I23","v":3}]
[null,22,22,"P","L","L",6,0,76,0,56,2,1,0,8,"b","e","b","e",14,6,81,12,12,12,14,17,21,24,25,22,19,22,"P",0.37,"-",0.57,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE36!I24","v":0}]
[null,23,23,"I","L","L",5,0,20,0,12,2,1,1,7,"b","b","b","i",18,11,72,17,19,22,24,21,18,14,12,12,11,23,"I",0.38,"-",0.55,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE36!I25","v":0},{"$nulls":12},"3. Disorder: 29 residues, predicted to be disordered in the full length protein, are predicted to be ordered in the protein produced by NF1delE35, while 1 residue is predicted to be disordered in the latter but not in neurofibromin. Out of those 29, 11 residues are in the CSRD at positions 801-813. However, all prediction reliabilities are very low. "]
[null,24,24,"K","L","L",5,0,114,0,56,3,1,1,6,"b","e","b","e",18,14,70,4,5,7,10,14,18,23,26,26,25,24,"K",0.39,"-",0.57,"D",0.57,"-",0.347,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE36!I26","v":0}]
[null,25,25,"T","L","L",6,0,127,0,90,2,1,1,7,"b","e","b","e",13,12,76,9,9,9,11,14,17,20,23,26,27,25,"T",0.41,"-",0.56,"D",0.5,"-",0.388,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE36!I27","v":-25}]
[null,26,26,"G","L","L",7,0,10,0,12,0,0,1,8,"b","b","b","i",8,11,82,19,19,20,21,20,19,18,16,15,14,26,"G",0.4,"-",0.51,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE36!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,1,7,"b","e","b","e",12,10,78,12,12,14,17,19,21,22,22,21,20,27,"Q",0.43,"-",0.58,"D",0.76,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE36!I29","v":0}]
[null,28,28,"Q","L","L",4,0,110,0,56,1,2,1,6,"b","e","b","e",20,16,64,10,11,13,16,18,20,21,22,21,20,28,"Q",0.48,"-",0.62,"D",0.77,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE36!I30","v":-27}]
[null,29,29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",27,19,59,12,12,13,16,18,20,21,21,19,18,29,"N",0.4,"-",0.59,"D",0.66,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE36!I31","v":0}]
[null,30,30,"T","L","L",2,0,28,0,20,0,2,1,5,"b","e","b","i",30,17,57,16,16,17,19,20,20,19,17,14,12,30,"T",0.36,"-",0.56,"D",0.66,"D",0.469,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE36!I32","v":0}]
[null,31,31,"H","L","L",2,0,77,0,42,1,3,1,5,"b","e","b","e",32,16,56,11,12,13,16,18,20,21,20,18,16,31,"H",0.34,"-",0.61,"D",0.76,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE36!I33","v":0}]
[null,32,32,"T","L","L",1,0,42,0,30,0,3,1,5,"b","e","b","i",37,12,56,13,13,15,17,19,20,20,19,17,15,32,"T",0.28,"-",0.58,"D",0.7,"D",0.469,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE36!I34","v":17},{"$nulls":12},"4. Protein Binding: Deletion of E35 leads to 17 newly predicted potential protein binding sites  (CSRD: six; GRD: two), while 14 potential binding sites, predicted in full length NF1, are now predicted to be lost (CSRD: one; GRD: two) - in addition to those in the deleted exon.    "]
[null,33,33,"K","L","L",0,0,86,0,42,1,4,1,4,"b","e","b","e",42,12,51,9,9,10,13,16,20,22,22,20,17,33,"K",0.34,"-",0.47,"D",0.68,"D",0.51,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE36!I35","v":0}]
[null,34,34,"V","L","H",1,0,42,0,30,1,5,1,3,"b","e","b","i",53,11,40,13,14,15,17,19,20,20,19,16,14,34,"V",0.27,"-",0.56,"D",0.79,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE36!I36","v":-14}]
[null,35,35,"S","L","H",2,0,26,0,20,0,5,0,3,"b","e","b","i",58,8,35,18,17,17,18,19,19,19,17,14,11,35,"S",0.22,"-",0.51,"D",0.86,"D",0.418,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE36!I37","v":13}]
[null,36,36,"T","L","H",4,0,28,0,20,0,6,0,2,"b","e","b","i",69,6,28,20,19,19,20,21,21,18,15,11,8,36,"T",0.18,"-",0.53,"D",0.77,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE36!I38","v":0}]
[null,37,37,"E","L","H",5,0,108,0,56,3,7,0,1,"b","e","b","e",76,6,19,5,6,7,10,14,18,23,25,24,22,37,"E",0.14,"-",0.56,"D",0.62,"D",0.394,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE36!I39","v":0}]
[null,38,38,"H","L","H",5,0,36,0,20,1,7,0,1,"b","e","b","i",76,7,19,18,17,18,20,22,22,20,16,11,8,38,"H",0.14,"-",0.47,"D",0.35,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE36!I40","v":0}]
[null,39,39,"N","L","H",5,0,0,0,0,4,7,0,2,"b","b","b","b",74,6,23,32,27,20,17,15,12,10,7,5,3,39,"N",0.13,"-",0.37,"-",0.47,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE36!I41","v":0}]
[null,40,40,"K","L","H",7,0,61,0,30,2,8,0,1,"b","e","b","i",87,3,11,13,13,15,19,22,24,23,18,13,9,40,"K",0.14,"-",0.41,"-",0.33,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G42-delE36!I42","v":0}]
[null,41,41,"E","L","H",7,0,81,0,42,2,8,0,1,"b","e","b","e",88,3,11,12,13,14,16,19,22,23,22,18,15,41,"E",0.17,"-",0.45,"-",0.36,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G43-delE36!I43","v":0}]
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[null,2807,2770,"G","L","L",3,0,10,0,12,1,2,1,5,"b","b","b","i",27,15,62,18,19,21,23,22,19,16,14,13,12,2770,"G",0.54,"D",0.5,"D",0.85,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE36!I2809","v":15}]
[null,2808,2771,"S","L","L",3,0,54,0,42,1,2,1,5,"b","e","b","e",32,15,62,14,14,14,17,19,22,23,22,19,16,2771,"S",0.59,"D",0.52,"D",0.73,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE36!I2810","v":-54}]
[null,2809,2772,"F","L","L",0,0,23,0,12,1,3,1,4,"b","b","b","i",39,20,46,19,20,21,23,22,20,17,15,14,13,2772,"F",0.65,"D",0.64,"D",0.83,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE36!I2811","v":-23}]
[null,2810,2773,"K","L","L",1,0,86,0,42,1,3,1,5,"b","e","b","e",36,15,52,9,9,10,14,17,21,23,23,21,19,2773,"K",0.61,"D",0.64,"D",0.91,"D",0.677,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE36!I2812","v":0}]
[null,2811,2774,"R","L","H",0,0,104,0,42,1,4,1,4,"b","e","b","e",50,12,42,6,7,10,14,18,22,25,25,22,19,2774,"R",0.65,"D",0.65,"D",0.86,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE36!I2813","v":-30}]
[null,2812,2775,"N","L","H",0,0,65,0,42,0,5,0,4,"b","e","b","e",53,8,45,6,7,9,13,17,20,22,22,22,21,2775,"N",0.34,"-",0.74,"D",0.83,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE36!I2814","v":48}]
[null,2813,2776,"S","L","H",1,0,93,0,72,1,5,0,3,"b","e","b","e",58,10,43,9,10,11,14,16,18,21,22,23,22,2776,"S",0.26,"-",0.68,"D",0.8,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE36!I2815","v":-21}]
[null,2814,2777,"I","L","H",1,0,70,0,42,0,5,1,3,"b","e","b","e",58,12,42,12,13,14,17,19,20,21,20,19,18,2777,"I",0.42,"-",0.66,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE36!I2816","v":-20}]
[null,2815,2778,"K","L","L",0,0,147,0,72,2,4,1,4,"b","e","b","e",44,15,51,3,4,6,10,14,19,24,27,28,26,2778,"K",0.34,"-",0.81,"D",0.81,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE36!I2817","v":0}]
[null,2816,2779,"K","L","L",2,0,184,0,90,3,2,1,5,"b","e","b","e",32,18,61,3,3,5,8,12,16,21,26,29,31,2779,"K",0.42,"-",0.81,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE36!I2818","v":-37}]
[null,2817,2780,"I","L","L",5,0,152,0,90,0,1,1,6,"b","e","b","e",16,16,72,10,11,13,16,18,19,19,18,19,20,2780,"I",0.38,"-",0.83,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE36!I2819","v":-132}]
[null,2818,2781,"V","L","L",8,0,127,0,90,4,0,0,9,"b","e","b","e",2,5,94,7,6,6,8,10,12,15,17,26,30,2781,"V",0.35,"-",0.88,"D",0.74,"D",0.541,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE36!I2820","v":0}]
[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":4246}]
[{"$nulls":55},{"$f":"SUM(BD2:BD2820)-SUM(BD1557:BD1593)","v":2894}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},37,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":108},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":140},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":293},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":73},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":346},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.038834951456310676,"d":"4%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.12441567781373607,"d":"12%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":183},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":116},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":43},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":4},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":74},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":24},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":7},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":1},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":17}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":29},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":14}]

{"sheet":"delE41","index":10,"n_rows":2864,"n_cols":68,"rows_kept":2250,"cut":true,"merged":[[0,1,0,42],[7,67,10,117],[14,67,20,117],[24,67,27,117],[31,67,34,117],[1983,1,2029,42],[2822,53,2834,54]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
[null,"delE41"]
["No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE40)"]
[1,1,"M","L","L",9,0,169,0,90,3,0,0,9,"b","e","b","e",1,1,96,8,8,8,10,11,13,14,16,24,27,1,"M",0.32,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE41!H3","v":0}]
[{"$f":"A3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",9,7,85,6,6,7,10,13,16,19,21,26,28,2,"A",0.21,"-",0.86,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE41!H4","v":0}]
[{"$f":"A4+1","v":3},3,"A","L","L",6,0,76,0,72,1,1,0,7,"b","e","b","e",13,8,82,7,7,9,13,16,20,22,23,25,24,3,"A",0.1,"-",0.82,"D",0.36,"-",0.556,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE41!H5","v":0},{"$nulls":12},"SUMMARY: "]
[4,4,"H","L","L",5,0,132,0,72,2,1,1,7,"b","e","b","e",20,11,73,7,8,10,13,16,19,22,24,26,25,4,"H",0.12,"-",0.83,"D",0.29,"-",0.505,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE41!H6","v":0}]
[5,5,"R","L","L",5,0,104,0,42,3,1,0,7,"b","e","b","e",17,10,75,6,7,10,15,21,25,27,24,20,16,5,"R",0.11,"-",0.69,"D",0.34,"-",0.449,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE41!H7","v":0}]
[6,6,"P","L","L",1,0,40,0,30,1,3,0,5,"b","e","b","i",41,5,57,16,16,17,19,21,22,21,18,15,13,6,"P",0.09,"-",0.62,"D",0.34,"-",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE41!H8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (3%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of neurofibromin. Most predicted changes in secondary structure have very low or low reliability (RI_S = 0-3), only 3 have medium or high relibility (RI_S = 4-7). "]
[7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",68,4,33,14,15,16,19,20,20,18,16,12,10,7,"V",0.22,"-",0.6,"D",0.28,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE41!H9","v":0}]
[8,8,"E","L","H",6,0,108,0,56,2,7,0,1,"b","e","b","e",80,7,16,7,8,9,12,16,20,24,25,21,17,8,"E",0.26,"-",0.54,"D",0.23,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE41!H10","v":0}]
[9,9,"W","L","H",8,0,0,0,0,3,8,0,0,"b","b","b","b",89,4,9,31,28,24,21,18,14,9,5,2,1,9,"W",0.21,"-",0.39,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE41!H11","v":0}]
[10,10,"V","L","H",8,0,0,0,0,7,9,0,0,"b","b","b","b",90,3,7,40,33,19,14,10,7,4,2,1,0,10,"V",0.11,"-",0.3,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE41!H12","v":0}]
[11,11,"Q","L","H",8,0,59,0,30,1,9,0,0,"b","e","b","i",93,1,5,16,16,17,20,22,23,20,14,7,3,11,"Q",0.09,"-",0.28,"-",0.18,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE41!H13","v":0}]
[12,12,"A","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",93,1,6,24,23,21,21,21,19,15,10,5,2,12,"A",0.13,"-",0.27,"-",0.25,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE41!H14","v":0}]
[13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,46,35,16,9,6,3,2,1,0,0,13,"V",0.11,"-",0.24,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE41!H15","v":0},{"$nulls":12},"2. Solvent Accessibility: 217 residues (8%) are predicted to have changed its classification (according to Pbie/Pbe; b=burried, i=intermediate, e=exposed). All predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-4). NF1delE40's net solvent accessibility appears to be similar to that of neurofibromin, if we disregard the lost solvent accessibility due to the deleted exon. "]
[14,14,"V","L","H",9,0,0,0,0,5,9,0,0,"b","b","b","b",95,1,3,34,29,20,16,13,9,6,4,2,1,14,"V",0.12,"-",0.33,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE41!H16","v":0}]
[15,15,"S","L","H",8,0,54,0,42,3,9,0,0,"b","e","b","e",91,1,7,8,9,11,14,18,22,24,21,14,9,15,"S",0.14,"-",0.42,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE41!H17","v":0}]
[16,16,"R","L","H",8,0,29,0,12,3,8,0,0,"b","b","b","i",90,2,10,15,18,22,26,26,22,16,9,4,2,16,"R",0.14,"-",0.39,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE41!H18","v":0}]
[17,17,"F","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",91,1,8,43,34,20,13,9,6,3,2,1,0,17,"F",0.21,"-",0.4,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE41!H19","v":0}]
[18,18,"D","L","H",7,0,68,0,42,2,8,0,0,"b","e","b","e",89,2,10,12,12,14,17,20,23,24,21,15,11,18,"D",0.25,"-",0.6,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE41!H20","v":0}]
[19,19,"E","L","H",4,0,139,0,72,3,7,0,2,"b","e","b","e",73,2,27,4,5,6,9,12,16,21,25,27,26,19,"E",0.29,"-",0.59,"D",0.55,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE41!H21","v":0}]
[20,20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",56,4,43,8,10,14,20,23,26,24,20,14,9,20,"Q",0.28,"-",0.6,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE41!H22","v":0}]
[21,21,"L","L","L",6,0,3,0,2,3,1,0,8,"b","b","b","b",14,4,82,28,29,28,25,19,13,8,5,3,2,21,"L",0.31,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE41!H23","v":0}]
[22,22,"P","L","L",7,0,76,0,56,2,1,0,8,"b","e","b","e",11,6,83,12,11,11,13,16,20,24,25,23,20,22,"P",0.37,"-",0.59,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE41!H24","v":0}]
[23,23,"I","L","L",5,0,20,0,12,2,1,1,7,"b","b","b","i",17,13,73,17,20,23,24,22,18,14,12,11,11,23,"I",0.36,"-",0.55,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE41!H25","v":0},{"$nulls":12},"3. Disorder: 14 residues, predicted to be disordered in the full length protein are predicted to not be disordered in the protein produced by NF1delE40, while 2 residues are predicted to be disordered in the latter but not in neurofibromin. All these difference are in isolated single or pairs of residues and predictions have very low reliability."]
[24,24,"K","L","L",4,0,147,0,72,2,1,1,6,"b","e","b","e",20,15,68,5,5,7,10,14,18,22,25,26,25,24,"K",0.39,"-",0.56,"D",0.57,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE41!H26","v":-33}]
[25,25,"T","L","L",6,0,127,0,90,2,1,1,7,"b","e","b","e",14,11,76,9,9,9,11,14,17,20,23,26,27,25,"T",0.4,"-",0.56,"D",0.5,"-",0.394,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE41!H27","v":-25}]
[26,26,"G","L","L",7,0,10,0,12,0,0,1,8,"b","b","b","i",9,11,82,19,19,20,21,20,19,17,16,14,14,26,"G",0.39,"-",0.51,"D",0.66,"D",0.455,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE41!H28","v":0}]
[27,27,"Q","L","L",6,0,83,0,42,0,1,1,7,"b","e","b","e",13,10,77,11,12,14,17,19,21,22,22,21,20,27,"Q",0.44,"-",0.58,"D",0.76,"D",0.48,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE41!H29","v":0}]
[28,28,"Q","L","L",4,0,110,0,56,1,2,1,6,"b","e","b","e",22,16,62,10,11,13,16,18,20,21,22,21,20,28,"Q",0.52,"D",0.64,"D",0.77,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE41!H30","v":-27}]
[29,29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",27,16,62,11,12,13,16,18,20,21,21,20,19,29,"N",0.42,"-",0.61,"D",0.66,"D",0.52,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE41!H31","v":0}]
[30,30,"T","L","L",3,0,28,0,20,0,2,1,5,"b","e","b","i",30,14,60,16,16,17,19,20,20,19,17,15,13,30,"T",0.4,"-",0.58,"D",0.66,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE41!H32","v":0},{"$nulls":12},"4. Protein Binding: Deletion of E40 leads to 14 newly predicted potential protein binding sites (CSRD: one, GRD: three), while 13 potential binding sites predicted in full length NF1 are now predicted to be lost in the protein NF1del40 (CSRD: two; GRD: two) - in addition to those in the deleted exon."]
[31,31,"H","L","L",2,0,77,0,42,1,3,1,5,"b","e","b","e",35,14,56,11,12,13,16,18,20,21,20,18,16,31,"H",0.37,"-",0.61,"D",0.76,"D",0.525,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE41!H33","v":0}]
[32,32,"T","L","L",1,0,59,0,42,0,3,1,5,"b","e","b","e",39,13,52,12,12,13,16,17,19,20,20,19,18,32,"T",0.28,"-",0.59,"D",0.7,"D",0.49,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE41!H34","v":0}]
[33,33,"K","L","L",0,0,86,0,42,1,4,1,4,"b","e","b","e",44,13,47,8,9,10,13,16,20,22,22,20,18,33,"K",0.34,"-",0.46,"-",0.68,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE41!H35","v":0}]
[34,34,"V","L","H",1,0,28,0,20,0,5,1,3,"b","e","b","i",53,11,37,14,14,15,18,20,20,20,19,16,14,34,"V",0.27,"-",0.56,"D",0.79,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE41!H36","v":0}]
[35,35,"S","L","H",2,0,39,0,30,0,5,0,3,"b","e","b","i",58,10,35,17,17,16,18,19,20,19,18,14,12,35,"S",0.23,"-",0.49,"D",0.86,"D",0.424,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE41!H37","v":0}]
[36,36,"T","L","H",3,0,28,0,20,0,6,0,2,"b","e","b","i",65,7,30,19,19,19,20,21,21,18,15,11,8,36,"T",0.19,"-",0.54,"D",0.77,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE41!H38","v":0}]
[37,37,"E","L","H",4,0,108,0,56,3,7,0,2,"b","e","b","e",72,7,23,5,6,8,11,14,18,23,25,24,22,37,"E",0.15,"-",0.57,"D",0.62,"D",0.404,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE41!H39","v":0}]
[38,38,"H","L","H",5,0,36,0,20,1,7,0,2,"b","e","b","i",73,9,22,18,17,18,20,22,22,20,16,12,9,38,"H",0.14,"-",0.47,"D",0.35,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE41!H40","v":0}]
[39,39,"N","L","H",4,0,0,0,0,4,6,0,2,"b","b","b","b",71,7,25,31,27,20,17,15,12,10,8,5,4,39,"N",0.13,"-",0.37,"-",0.47,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE41!H41","v":0}]
[40,40,"K","L","H",7,0,61,0,30,2,8,0,1,"b","e","b","i",84,5,13,12,13,15,19,22,24,23,19,13,10,40,"K",0.14,"-",0.41,"-",0.33,"-",0.31,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G42-delE41!H42","v":0}]
[41,41,"E","L","H",6,0,81,0,42,1,8,0,1,"b","e","b","e",83,5,14,13,13,14,17,19,22,23,22,18,15,41,"E",0.17,"-",0.46,"-",0.36,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G43-delE41!H43","v":0}]
[42,42,"C","L","H",6,0,0,0,0,3,7,1,1,"b","b","b","b",78,12,13,30,27,23,20,17,14,10,6,3,2,42,"C",0.2,"-",0.3,"-",0.41,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G44-delE41!H44","v":0}]
[43,43,"L","L","H",5,0,0,0,0,8,7,1,1,"b","b","b","b",75,17,14,41,33,19,13,10,7,5,3,2,1,43,"L",0.2,"-",0.28,"-",0.32,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G45-delE41!H45","v":0}]
[44,44,"I","L","H",5,0,0,0,0,3,6,1,1,"b","b","b","b",69,19,17,31,28,22,18,15,11,9,6,4,3,44,"I",0.12,"-",0.41,"-",0.4,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G46-delE41!H46","v":0}]
[45,45,"N","L","H",4,0,47,0,30,1,6,1,2,"b","e","b","i",67,16,22,17,17,17,19,21,22,20,16,12,9,45,"N",0.08,"-",0.4,"-",0.21,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G47-delE41!H47","v":0}]
[46,46,"I","L","H",3,0,0,0,0,5,6,1,2,"b","b","b","b",64,11,28,35,30,23,18,14,11,7,5,3,2,46,"I",0.08,"-",0.41,"-",0.2,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G48-delE41!H48","v":0}]
[47,47,"S","L","H",1,0,0,0,0,4,5,0,3,"b","b","b","b",54,8,40,34,29,22,18,15,11,8,6,4,3,47,"S",0.06,"-",0.45,"-",0.19,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G49-delE41!H49","v":0}]
[48,48,"K","L","H",2,0,86,0,42,1,6,0,3,"b","e","b","e",63,6,36,14,14,14,16,19,21,22,22,20,18,48,"K",0.07,"-",0.59,"D",0.2,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G50-delE41!H50","v":0}]
[49,49,"Y","L","H",1,0,44,0,20,1,5,0,4,"b","e","b","i",54,6,44,18,18,20,22,23,21,17,13,10,8,49,"Y",0.09,"-",0.52,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G51-delE41!H51","v":-18}]
[50,50,"K","L","H",1,0,41,0,20,1,5,0,3,"b","e","b","i",58,6,40,17,17,17,19,21,21,19,15,10,8,50,"K",0.1,"-",0.48,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G52-delE41!H52","v":0}]
[51,51,"F","L","H",4,0,0,0,0,4,7,0,2,"b","b","b","b",74,4,25,34,30,23,19,14,11,7,5,3,2,51,"F",0.12,"-",0.36,"-",0.26,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G53-delE41!H53","v":0}]
[52,52,"S","L","H",7,0,0,0,0,1,8,0,1,"b","b","b","b",85,3,15,24,22,19,19,18,17,14,11,7,5,52,"S",0.1,"-",0.34,"-",0.18,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G54-delE41!H54","v":0}]
[53,53,"L","L","H",8,0,0,0,0,4,9,0,0,"b","b","b","b",91,3,7,31,27,19,16,14,12,8,5,3,2,53,"L",0.15,"-",0.3,"-",0.15,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G55-delE41!H55","v":0}]
[54,54,"V","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",94,3,5,46,36,17,11,7,4,2,1,0,0,54,"V",0.1,"-",0.27,"-",0.18,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G56-delE41!H56","v":0}]
[55,55,"I","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,2,4,43,34,17,11,7,4,3,1,0,0,55,"I",0.07,"-",0.26,"-",0.13,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G57-delE41!H57","v":0}]
[56,56,"S","L","H",8,0,0,0,0,2,9,0,0,"b","b","b","b",94,1,5,26,24,20,18,17,15,12,8,5,3,56,"S",0.08,"-",0.32,"-",0.13,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G58-delE41!H58","v":0}]
[57,57,"G","L","H",8,0,0,0,0,5,9,0,0,"b","b","b","b",93,1,5,34,28,18,15,12,10,7,4,2,1,57,"G",0.08,"-",0.24,"-",0.14,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G59-delE41!H59","v":0}]
[58,58,"L","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",96,0,3,47,36,15,8,5,3,1,0,0,0,58,"L",0.08,"-",0.26,"-",0.18,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G60-delE41!H60","v":0}]
[59,59,"T","L","H",9,0,0,0,0,3,9,0,0,"b","b","b","b",95,1,3,28,25,20,18,16,13,9,6,3,2,59,"T",0.1,"-",0.34,"-",0.18,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G61-delE41!H61","v":0}]
[60,60,"T","L","H",8,0,42,0,30,3,9,0,0,"b","e","b","i",92,1,7,10,11,13,17,21,24,23,18,10,6,60,"T",0.13,"-",0.41,"-",0.24,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G62-delE41!H62","v":0}]
[61,61,"I","L","H",8,0,0,0,0,3,9,0,0,"b","b","b","b",92,1,7,31,27,21,18,15,11,7,3,1,0,61,"I",0.16,"-",0.36,"-",0.24,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G63-delE41!H63","v":0}]
[62,62,"L","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",93,1,5,44,34,18,11,7,4,3,2,1,0,62,"L",0.18,"-",0.38,"-",0.19,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G64-delE41!H64","v":0}]
[63,63,"K","L","H",8,0,114,0,56,3,8,0,0,"b","e","b","e",91,2,9,6,6,8,11,15,21,26,27,20,15,63,"K",0.14,"-",0.51,"D",0.28,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G65-delE41!H65","v":0}]
[64,64,"N","L","H",6,0,47,0,30,2,8,0,1,"b","e","b","i",80,2,18,11,12,14,18,21,23,21,18,13,9,64,"N",0.21,"-",0.57,"D",0.21,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G66-delE41!H66","v":0}]
[65,65,"V","L","H",4,0,0,0,0,4,6,0,2,"b","b","b","b",69,4,29,33,30,23,19,15,10,6,4,2,2,65,"V",0.28,"-",0.51,"D",0.16,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G67-delE41!H67","v":0}]
[66,66,"N","L","H",2,0,65,0,42,1,5,0,3,"b","e","b","e",63,5,41,16,16,16,18,20,21,22,21,18,15,66,"N",0.29,"-",0.56,"D",0.2,"-",0.32,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G68-delE41!H68","v":0}]
[{"$f":"A68+1","v":67},67,"N","L","H",0,0,87,0,56,3,4,0,4,"b","e","b","e",51,6,51,4,5,7,11,15,20,25,27,25,21,67,"N",0.33,"-",0.64,"D",0.33,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G69-delE41!H69","v":0}]
[68,68,"M","L","L",2,0,22,0,12,1,3,0,5,"b","b","b","i",37,10,59,17,18,21,22,21,18,15,13,12,11,68,"M",0.34,"-",0.64,"D",0.24,"-",0.374,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G70-delE41!H70","v":34}]
[69,69,"R","L","L",4,0,104,0,42,1,2,1,6,"b","e","b","e",26,14,68,9,10,12,15,19,21,23,23,21,19,69,"R",0.41,"-",0.62,"D",0.22,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G71-delE41!H71","v":0}]
[70,70,"I","L","L",5,0,33,0,20,0,1,1,6,"b","e","b","i",21,15,72,13,14,16,18,20,20,20,19,19,18,70,"I",0.42,"-",0.63,"D",0.32,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G72-delE41!H72","v":0}]
[71,71,"F","L","L",6,0,59,0,30,0,1,1,7,"b","e","b","i",15,14,75,10,11,13,17,19,20,20,19,19,18,71,"F",0.42,"-",0.64,"D",0.41,"-",0.374,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G73-delE41!H73","v":0}]
[72,72,"G","L","L",6,0,60,0,72,1,1,0,7,"b","e","b","e",15,10,77,9,10,12,15,17,19,21,22,24,24,72,"G",0.44,"-",0.68,"D",0.41,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G74-delE41!H74","v":0}]
[73,73,"E","L","L",5,0,174,0,90,2,1,0,7,"b","e","b","e",20,10,73,5,5,7,11,14,18,21,24,27,28,73,"E",0.42,"-",0.71,"D",0.39,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G75-delE41!H75","v":-35}]
[74,74,"A","L","L",5,0,76,0,72,1,1,1,7,"b","e","b","e",18,10,72,9,10,12,15,17,19,20,21,23,23,74,"A",0.35,"-",0.7,"D",0.27,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G76-delE41!H76","v":-45}]
[75,75,"A","L","L",5,0,21,0,20,0,1,0,7,"b","e","b","i",19,10,73,11,12,15,18,21,21,21,18,16,14,75,"A",0.35,"-",0.62,"D",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G77-delE41!H77","v":0}]
[76,76,"E","L","L",3,0,139,0,72,1,3,0,6,"b","e","b","e",34,8,66,7,8,9,12,15,19,22,23,25,25,76,"E",0.29,"-",0.62,"D",0.4,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G78-delE41!H78","v":0}]
[77,77,"K","L","L",2,0,114,0,56,1,3,0,5,"b","e","b","e",39,8,59,7,8,10,13,16,19,21,22,22,21,77,"K",0.26,"-",0.66,"D",0.45,"-",0.31,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G79-delE41!H79","v":0}]
[78,78,"N","L","L",1,0,47,0,30,1,3,1,4,"b","e","b","i",42,15,52,15,16,17,19,20,21,19,17,14,12,78,"N",0.26,"-",0.56,"D",0.27,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G80-delE41!H80","v":-16}]
[79,79,"L","L","L",0,0,0,0,0,0,3,1,4,"b","b","b","b",41,19,47,23,23,23,23,20,17,13,9,6,5,79,"L",0.22,"-",0.49,"D",0.21,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G81-delE41!H81","v":0}]
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[1958,1958,"I","L","H",7,0,0,0,0,7,8,0,1,"b","b","b","b",86,4,11,39,32,19,13,9,7,4,3,1,1,1958,"I",0.09,"-",0.3,"-",0.19,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1960-delE41!H1960","v":0}]
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[1985,{"$nulls":53},{"$f":"Nf1fl!G1987","v":0}]
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[1990,{"$nulls":53},{"$f":"Nf1fl!G1992","v":0}]
[1991,{"$nulls":53},{"$f":"Nf1fl!G1993","v":32}]
[1993,{"$nulls":53},{"$f":"Nf1fl!G1995","v":0}]
[1994,{"$nulls":53},{"$f":"Nf1fl!G1996","v":0}]
[1997,{"$nulls":53},{"$f":"Nf1fl!G1999","v":0}]
[1998,{"$nulls":53},{"$f":"Nf1fl!G2000","v":0}]
[2000,{"$nulls":53},{"$f":"Nf1fl!G2002","v":25}]
[2001,{"$nulls":53},{"$f":"Nf1fl!G2003","v":47}]
[2003,{"$nulls":53},{"$f":"Nf1fl!G2005","v":60}]
[2004,{"$nulls":53},{"$f":"Nf1fl!G2006","v":93}]
[2006,{"$nulls":53},{"$f":"Nf1fl!G2008","v":86}]
[2007,{"$nulls":53},{"$f":"Nf1fl!G2009","v":12}]
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[2013,{"$nulls":53},{"$f":"Nf1fl!G2015","v":0}]
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[2774,2727,"D","L","L",4,0,68,0,42,0,2,1,6,"b","e","b","e",26,11,69,9,10,11,14,17,20,23,23,22,21,2727,"D",0.73,"D",0.69,"D",0.75,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2776-delE41!H2776","v":0}]
[2775,2728,"K","L","L",3,0,114,0,56,2,2,1,6,"b","e","b","e",32,11,65,7,8,10,13,16,19,22,23,23,23,2728,"K",0.71,"D",0.74,"D",0.75,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2777-delE41!H2777","v":33}]
[2776,2729,"E","L","L",4,0,174,0,90,1,2,0,6,"b","e","b","e",27,10,69,6,7,9,12,15,19,21,24,25,26,2729,"E",0.72,"D",0.68,"D",0.75,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2778-delE41!H2778","v":-35}]
[2777,2730,"N","L","L",4,0,87,0,56,2,2,1,6,"b","e","b","e",24,11,70,8,9,11,14,16,20,22,24,24,23,2730,"N",0.66,"D",0.67,"D",0.77,"D",0.622,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2779-delE41!H2779","v":-22}]
[2778,2731,"V","L","L",4,0,28,0,20,1,2,1,6,"b","e","b","i",24,14,69,16,16,18,20,21,21,18,16,13,11,2731,"V",0.67,"D",0.64,"D",0.86,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2780-delE41!H2780","v":0}]
[2779,2732,"E","L","L",4,0,81,0,42,0,1,1,6,"b","e","b","e",21,17,68,11,12,14,17,20,21,22,21,20,19,2732,"E",0.63,"D",0.6,"D",0.79,"D",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2781-delE41!H2781","v":0}]
[2780,2733,"L","L","L",4,0,91,0,56,0,1,1,6,"b","e","b","e",20,17,66,13,13,14,16,18,20,20,21,21,21,2733,"L",0.64,"D",0.54,"D",0.64,"D",0.576,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2782-delE41!H2782","v":-23}]
[2781,2734,"S","L","L",6,0,15,0,12,0,0,1,7,"b","b","b","i",10,16,77,21,21,21,22,21,19,16,13,11,9,2734,"S",0.62,"D",0.48,"D",0.44,"-",0.566,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2783-delE41!H2783","v":0}]
[2782,2735,"P","L","L",6,0,16,0,12,0,1,1,7,"b","b","b","i",13,16,76,20,20,20,21,20,20,18,17,15,14,2735,"P",0.63,"D",0.52,"D",0.44,"-",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2784-delE41!H2784","v":0}]
[2783,2736,"T","L","L",6,0,0,0,0,0,1,1,7,"b","b","b","b",11,14,79,21,21,20,21,20,19,17,15,13,12,2736,"T",0.61,"D",0.46,"-",0.54,"-",0.582,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2785-delE41!H2785","v":0}]
[2784,2737,"T","L","L",5,0,0,0,0,0,1,1,6,"b","b","b","b",17,14,70,21,21,20,21,20,19,17,15,13,12,2737,"T",0.66,"D",0.49,"D",0.44,"-",0.582,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2786-delE41!H2786","v":0}]
[2785,2738,"G","L","L",4,0,25,0,30,0,2,1,6,"b","e","b","i",21,13,70,14,14,15,17,19,21,21,20,20,19,2738,"G",0.7,"D",0.53,"D",0.6,"D",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2787-delE41!H2787","v":0}]
[2786,2739,"H","L","L",4,0,55,0,30,1,2,1,6,"b","e","b","i",25,16,66,12,13,16,19,22,23,22,20,18,17,2739,"H",0.7,"D",0.54,"D",0.57,"-",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2788-delE41!H2788","v":0}]
[2787,2740,"C","L","L",5,0,27,0,20,1,1,1,6,"b","e","b","i",19,14,71,14,15,17,19,21,21,19,17,16,16,2740,"C",0.71,"D",0.51,"D",0.57,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2789-delE41!H2789","v":0}]
[2788,2741,"N","L","L",6,0,141,0,90,2,1,1,7,"b","e","b","e",14,11,77,8,8,10,12,15,17,19,21,25,27,2741,"N",0.68,"D",0.47,"D",0.55,"-",0.602,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2790-delE41!H2790","v":0}]
[2789,2742,"S","L","L",6,0,117,0,90,0,1,1,7,"b","e","b","e",12,12,78,11,11,13,15,17,19,20,21,22,23,2742,"S",0.62,"D",0.52,"D",0.52,"-",0.612,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2791-delE41!H2791","v":-24}]
[2790,2743,"G","L","L",6,0,25,0,30,0,1,1,7,"b","e","b","i",12,14,77,13,14,16,18,20,21,20,19,18,17,2743,"G",0.43,"-",0.42,"-",0.57,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2792-delE41!H2792","v":0}]
[2791,2744,"R","L","L",4,0,49,0,20,1,1,2,6,"b","e","b","i",13,26,66,14,15,17,20,22,22,20,18,15,13,2744,"R",0.42,"-",0.51,"D",0.59,"D",0.602,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2793-delE41!H2793","v":0}]
[2792,2745,"T","L","L",3,0,42,0,30,1,1,2,6,"b","e","b","i",15,26,64,18,18,18,20,21,22,20,17,14,13,2745,"T",0.5,"-",0.48,"D",0.74,"D",0.616,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2794-delE41!H2794","v":-14}]
[2793,2746,"R","L","L",2,0,29,0,12,0,1,2,5,"b","b","b","i",15,31,60,19,20,21,22,21,19,16,12,9,8,2746,"R",0.51,"-",0.4,"-",0.76,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2795-delE41!H2795","v":0}]
[2794,2747,"H","L","L",3,0,0,0,0,0,1,2,6,"b","b","b","b",15,27,64,22,21,21,21,20,18,16,13,11,9,2747,"H",0.56,"D",0.42,"-",0.66,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2796-delE41!H2796","v":0}]
[2795,2748,"G","L","L",4,0,10,0,12,0,1,2,6,"b","b","b","i",20,23,66,20,21,21,22,21,20,18,15,13,11,2748,"G",0.59,"D",0.51,"D",0.73,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2797-delE41!H2797","v":0}]
[2796,2749,"S","L","L",4,0,0,0,0,0,2,1,6,"b","b","b","b",26,17,67,23,22,20,20,20,19,17,15,13,12,2749,"S",0.65,"D",0.46,"-",0.83,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2798-delE41!H2798","v":0}]
[2797,2750,"A","L","L",0,0,0,0,0,1,4,1,4,"b","b","b","b",44,13,53,24,22,20,20,20,18,16,15,14,13,2750,"A",0.69,"D",0.41,"-",0.87,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2799-delE41!H2799","v":0}]
[2798,2751,"S","L","L",1,0,39,0,30,0,3,0,5,"b","e","b","i",43,11,57,14,14,15,18,20,21,21,21,20,19,2751,"S",0.67,"D",0.57,"D",0.87,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2800-delE41!H2800","v":0}]
[2799,2752,"Q","L","L",1,0,83,0,42,0,3,1,5,"b","e","b","e",39,13,54,9,10,12,16,19,22,23,23,22,20,2752,"Q",0.68,"D",0.65,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE41!H2801","v":0}]
[2800,2753,"V","L","L",2,0,28,0,20,1,3,1,5,"b","e","b","i",33,20,56,15,15,16,19,21,21,20,17,15,14,2753,"V",0.68,"D",0.62,"D",0.91,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE41!H2802","v":0}]
[2801,2754,"Q","L","L",4,0,83,0,42,1,2,2,5,"b","e","b","e",24,22,64,12,12,14,17,20,21,22,21,19,18,2754,"Q",0.67,"D",0.69,"D",0.88,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE41!H2803","v":0}]
[2802,2755,"K","L","L",5,0,147,0,72,2,1,1,6,"b","e","b","e",21,17,71,6,7,9,12,16,20,23,26,27,26,2755,"K",0.67,"D",0.66,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE41!H2804","v":0}]
[2803,2756,"Q","L","L",5,0,110,0,56,1,1,1,7,"b","e","b","e",16,15,75,8,9,12,15,19,21,22,23,22,21,2756,"Q",0.59,"D",0.62,"D",0.79,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE41!H2805","v":0}]
[2804,2757,"R","L","L",5,0,138,0,56,1,1,1,6,"b","e","b","e",21,16,71,9,10,12,15,18,21,23,24,23,22,2757,"R",0.61,"D",0.64,"D",0.87,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE41!H2806","v":0}]
[2805,2758,"S","L","L",4,0,26,0,20,0,2,1,6,"b","e","b","i",22,14,70,17,17,18,20,21,20,19,18,17,17,2758,"S",0.62,"D",0.58,"D",0.93,"D",0.663,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE41!H2807","v":0}]
[2806,2759,"A","L","L",3,0,44,0,42,0,2,1,6,"b","e","b","e",29,12,68,13,14,15,18,19,20,21,20,21,20,2759,"A",0.63,"D",0.59,"D",0.92,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE41!H2808","v":-13}]
[2807,2760,"G","L","L",4,0,25,0,30,0,2,1,6,"b","e","b","i",27,12,69,14,15,16,19,20,21,21,20,19,18,2760,"G",0.59,"D",0.53,"D",0.85,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE41!H2809","v":0}]
[2808,2761,"S","L","L",3,0,0,0,0,0,2,1,6,"b","b","b","b",28,14,66,21,20,19,20,20,20,18,17,15,14,2761,"S",0.6,"D",0.54,"D",0.73,"D",0.653,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE41!H2810","v":0}]
[2809,2762,"F","L","L",2,0,0,0,0,0,2,2,5,"b","b","b","b",29,24,56,25,24,22,22,19,16,12,10,9,8,2762,"F",0.71,"D",0.61,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE41!H2811","v":0}]
[2810,2763,"K","L","L",3,0,114,0,56,2,2,1,5,"b","e","b","e",27,20,60,7,7,9,12,16,20,23,24,24,22,2763,"K",0.61,"D",0.58,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE41!H2812","v":-28}]
[2811,2764,"R","L","L",2,0,74,0,30,1,3,1,5,"b","e","b","i",37,14,57,7,9,13,18,22,24,23,21,18,16,2764,"R",0.71,"D",0.64,"D",0.86,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE41!H2813","v":0}]
[2812,2765,"N","L","L",1,0,113,0,72,1,3,0,5,"b","e","b","e",44,9,59,6,7,9,13,16,19,21,22,24,24,2765,"N",0.38,"-",0.73,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE41!H2814","v":0}]
[2813,2766,"S","L","L",0,0,72,0,56,1,4,1,4,"b","e","b","e",53,12,52,9,10,12,15,17,20,22,23,23,22,2766,"S",0.29,"-",0.6,"D",0.8,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE41!H2815","v":0}]
[2814,2767,"I","L","L",0,0,50,0,30,0,4,1,4,"b","e","b","i",51,14,51,15,15,16,18,19,20,20,19,19,18,2767,"I",0.44,"-",0.59,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE41!H2816","v":0}]
[2815,2768,"K","L","L",1,0,147,0,72,3,3,1,5,"b","e","b","e",36,19,55,3,3,6,9,13,17,23,26,27,27,2768,"K",0.31,"-",0.7,"D",0.81,"D",0.653,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE41!H2817","v":0}]
[2816,2769,"K","L","L",2,0,147,0,72,1,2,2,4,"b","e","b","e",31,28,52,6,7,8,11,15,18,22,23,24,24,2769,"K",0.36,"-",0.79,"D",0.77,"D",0.582,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE41!H2818","v":0}]
[2817,2770,"I","L","L",3,0,20,0,12,0,1,2,5,"b","b","b","i",16,26,61,19,19,20,21,20,17,15,13,13,13,2770,"I",0.35,"-",0.76,"D",0.77,"D",0.576,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE41!H2819","v":0}]
[2818,2771,"V","L","L",8,0,127,0,90,3,0,0,8,"b","e","b","e",3,9,90,10,9,8,9,11,13,15,16,24,27,2771,"V",0.39,"-",0.84,"D",0.74,"D",0.545,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE41!H2820","v":0}]
[{"$nulls":53},"SUM:",{"$f":"SUM(BC1:BC2820)","v":1570}]
[{"$nulls":54},{"$f":"SUM(BC2:BC2820)-SUM(BC1984:BC2030)","v":463}]
[{"$nulls":6},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":6},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":6},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":6},"CSRD"]
[{"$nulls":6},"GRD"]
[{"$nulls":6},"Sec14 & PH"]
[{"$nulls":6},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":4},47,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":4},{"$f":"SUMPRODUCT(--(E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))-E2835","v":86},{"$nulls":10},{"$f":"SUMPRODUCT(--(P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820))-E2835","v":74},null,{"$f":"SUMPRODUCT(--(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-E2835","v":178},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BC3:BC2820)>=50))","v":36},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":16},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820) + (R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-E2835","v":217},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":4},{"$f":"E2837/(2818-E2835)","v":{"v":0.031035727174305305,"d":"3%"}},{"$nulls":11},{"$f":"Q2838/(2818-E2835)","v":{"v":0.07831107903284013,"d":"8%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=0))>0))-E2835","v":112},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=1))>0))","v":84},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=2))>0))","v":16},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=3))>0))","v":5},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=0))>0))-E2835","v":59},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=1))>0))","v":13},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=2))>0))","v":5},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=3))>0))","v":6},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=4))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=5))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=6))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=7))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":20},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AP3:AP2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":2},{"$f":"COUNTIFS(AQ3:AQ2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":14}]
[{"$nulls":20},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AP3:AP2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":14},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":13}]

{"sheet":"delE46","index":11,"n_rows":2864,"n_cols":69,"rows_kept":1125,"cut":true,"merged":[[0,2,0,43],[7,68,10,118],[14,68,20,118],[24,68,29,118],[33,68,35,118],[1175,0,1572,0],[2822,54,2834,55]],"bounds":{"rows_first":500,"rows_last":125,"rows_between":500,"halvings":2}}
[null,null,"delE46"]
[null,"No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE45)"]
[null,1,1,"M","L","L",9,0,169,0,90,3,0,0,9,"b","e","b","e",1,1,96,8,8,8,10,11,13,14,16,23,27,1,"M",0.31,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE46!I3","v":0}]
[null,{"$f":"B3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",8,8,85,7,7,8,11,14,17,19,20,25,27,2,"A",0.22,"-",0.86,"D",0.54,"-",0.576,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE46!I4","v":0}]
[null,{"$f":"B4+1","v":3},3,"A","L","L",7,0,76,0,72,1,1,0,8,"b","e","b","e",12,8,82,7,8,9,13,16,20,22,23,24,23,3,"A",0.09,"-",0.83,"D",0.36,"-",0.545,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE46!I5","v":0},{"$nulls":12},"SUMMARY:"]
[null,4,4,"H","L","L",5,0,132,0,72,2,1,1,6,"b","e","b","e",20,12,73,6,7,9,12,15,18,22,24,26,26,4,"H",0.12,"-",0.83,"D",0.29,"-",0.49,1,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE46!I6","v":0}]
[null,5,5,"R","L","L",6,0,104,0,42,2,1,1,7,"b","e","b","e",15,11,76,8,9,11,16,20,24,25,23,20,18,5,"R",0.1,"-",0.7,"D",0.34,"-",0.434,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE46!I7","v":0}]
[null,6,6,"P","L","L",2,0,40,0,30,2,3,0,5,"b","e","b","i",36,7,62,14,14,15,19,21,23,22,19,15,12,6,"P",0.09,"-",0.62,"D",0.34,"-",0.394,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE46!I8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (4%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of full length neurofibromin. The vast majority of predicted changes in secondary structure has very low or low reliability (RI_S = 0-3). Only 1 predicted changes in residue secondary structure has medium relibility (RI_S = 4-5). "]
[null,7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",66,4,35,14,14,16,20,21,21,18,16,12,9,7,"V",0.21,"-",0.57,"D",0.28,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE46!I9","v":0}]
[null,8,8,"E","L","H",6,0,108,0,56,3,7,0,1,"b","e","b","e",78,7,17,6,6,8,11,15,19,24,26,22,18,8,"E",0.26,"-",0.55,"D",0.23,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE46!I10","v":0}]
[null,9,9,"W","L","H",8,0,0,0,0,2,8,0,0,"b","b","b","b",89,4,8,30,28,23,22,19,15,10,6,3,1,9,"W",0.23,"-",0.39,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE46!I11","v":0}]
[null,10,10,"V","L","H",8,0,0,0,0,7,9,0,0,"b","b","b","b",91,3,7,40,33,19,14,11,7,4,2,1,0,10,"V",0.12,"-",0.31,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE46!I12","v":0}]
[null,11,11,"Q","L","H",8,0,59,0,30,2,9,0,0,"b","e","b","i",93,1,5,16,16,17,21,23,24,20,14,7,3,11,"Q",0.1,"-",0.28,"-",0.18,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE46!I13","v":0}]
[null,12,12,"A","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",92,1,5,23,22,21,22,21,19,15,10,5,2,12,"A",0.13,"-",0.26,"-",0.25,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE46!I14","v":0}]
[null,13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,47,35,15,8,5,3,2,1,0,0,13,"V",0.12,"-",0.26,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE46!I15","v":0},{"$nulls":12},"2. Solvent Accessibility: 333 residues (12%) are predicted to have changed their classification (according to Pbie or Pbe, with b=burried, i=intermediate, e=exposed). Almost all predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-4). NF1delE45 may have an overall solvent accessibility that is further reduced, beyond what is attributed to the deleted exon. "]
[null,14,14,"V","L","H",9,0,0,0,0,4,9,0,0,"b","b","b","b",95,1,3,33,29,21,17,14,10,7,4,2,1,14,"V",0.13,"-",0.33,"-",0.37,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE46!I16","v":0}]
[null,15,15,"S","L","H",8,0,54,0,42,3,9,0,0,"b","e","b","e",91,1,8,8,9,11,14,18,22,24,21,14,9,15,"S",0.14,"-",0.42,"-",0.33,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE46!I17","v":0}]
[null,16,16,"R","L","H",8,0,29,0,12,3,8,0,0,"b","b","b","i",90,2,9,15,18,22,26,26,22,16,9,4,2,16,"R",0.14,"-",0.38,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE46!I18","v":0}]
[null,17,17,"F","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",90,1,8,43,34,20,13,9,6,3,2,1,0,17,"F",0.21,"-",0.4,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE46!I19","v":0}]
[null,18,18,"D","L","H",7,0,68,0,42,2,8,0,1,"b","e","b","e",88,2,11,12,13,14,17,20,23,24,21,15,11,18,"D",0.24,"-",0.6,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE46!I20","v":0}]
[null,19,19,"E","L","H",4,0,139,0,72,3,6,0,2,"b","e","b","e",72,3,29,4,5,6,9,12,16,21,26,27,27,19,"E",0.29,"-",0.59,"D",0.55,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE46!I21","v":0}]
[null,20,20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",55,4,44,7,9,13,19,23,26,25,21,15,10,20,"Q",0.29,"-",0.6,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE46!I22","v":0}]
[null,21,21,"L","L","L",7,0,3,0,2,2,1,0,8,"b","b","b","b",13,4,84,28,29,28,26,20,14,8,4,3,2,21,"L",0.33,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE46!I23","v":0}]
[null,22,22,"P","L","L",7,0,57,0,42,1,1,0,8,"b","e","b","e",12,6,83,13,12,12,13,16,21,24,24,22,19,22,"P",0.37,"-",0.57,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE46!I24","v":19}]
[null,23,23,"I","L","L",5,0,20,0,12,2,1,1,7,"b","b","b","i",17,12,74,17,19,22,24,21,18,14,12,12,11,23,"I",0.37,"-",0.55,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE46!I25","v":0},{"$nulls":12},"3. Disorder: 31 residues, predicted to be disordered in the full length protein, are predicted to be ordered in the protein produced by NF1delE45. Out of those 31, 10 residues are in the CSRD at positions 801-813. However, all prediction reliabilities are very low. "]
[null,24,24,"K","L","L",5,0,147,0,72,2,1,1,6,"b","e","b","e",18,14,71,4,5,7,10,14,18,23,25,26,25,24,"K",0.42,"-",0.57,"D",0.57,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE46!I26","v":-33}]
[null,25,25,"T","L","L",6,0,127,0,90,2,1,0,7,"b","e","b","e",14,10,77,9,9,9,11,14,17,20,23,26,27,25,"T",0.42,"-",0.56,"D",0.5,"-",0.394,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE46!I27","v":-25}]
[null,26,26,"G","L","L",7,0,10,0,12,0,0,1,8,"b","b","b","i",9,11,82,19,19,20,21,20,19,18,16,15,14,26,"G",0.41,"-",0.51,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE46!I28","v":0}]
[null,27,27,"Q","L","L",6,0,83,0,42,0,1,1,7,"b","e","b","e",12,10,78,12,12,14,17,19,21,22,22,21,19,27,"Q",0.45,"-",0.57,"D",0.76,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE46!I29","v":0}]
[null,28,28,"Q","L","L",4,0,83,0,42,0,2,1,6,"b","e","b","e",21,16,64,10,11,13,16,18,20,21,21,21,19,28,"Q",0.49,"-",0.62,"D",0.77,"D",0.5,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE46!I30","v":0}]
[null,29,29,"N","L","L",3,0,47,0,30,0,2,1,5,"b","e","b","i",27,16,62,12,12,13,16,18,20,20,20,20,19,29,"N",0.41,"-",0.59,"D",0.66,"D",0.5,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE46!I31","v":18}]
[null,30,30,"T","L","L",2,0,28,0,20,0,2,1,5,"b","e","b","i",29,17,58,16,16,17,19,20,20,19,17,14,12,30,"T",0.4,"-",0.56,"D",0.66,"D",0.465,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE46!I32","v":0}]
[null,31,31,"H","L","L",2,0,77,0,42,1,3,1,5,"b","e","b","e",33,16,56,10,11,13,16,18,20,21,21,19,17,31,"H",0.35,"-",0.61,"D",0.76,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE46!I33","v":0}]
[null,32,32,"T","L","L",1,0,42,0,30,0,3,1,5,"b","e","b","i",36,14,55,13,13,15,17,19,20,20,19,17,16,32,"T",0.28,"-",0.59,"D",0.7,"D",0.455,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE46!I34","v":17},{"$nulls":12},"4. Protein Binding: Deletion of E45 leads to 13 newly predicted potential protein binding sites (CSRD: two; Tubulin BD: one; GRD: three; Sec14&PH: two), while 15 potential binding sites, predicted in full length NF1, are now predicted to be lost (CSRD: two; GRD: three) - in addition to those in the deleted exon.  "]
[null,33,33,"K","L","L",0,0,114,0,56,2,4,1,4,"b","e","b","e",42,13,50,8,9,10,13,16,20,22,23,21,19,33,"K",0.34,"-",0.47,"D",0.68,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE46!I35","v":-28}]
[null,34,34,"V","L","H",1,0,42,0,30,1,5,1,3,"b","e","b","i",52,11,39,13,13,15,18,19,21,20,19,17,15,34,"V",0.28,"-",0.57,"D",0.79,"D",0.495,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE46!I36","v":-14}]
[null,35,35,"S","L","H",2,0,26,0,20,0,5,0,3,"b","e","b","i",56,9,36,18,18,17,18,19,19,19,17,15,12,35,"S",0.22,"-",0.51,"D",0.86,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE46!I37","v":13}]
[null,36,36,"T","L","H",3,0,28,0,20,0,6,0,3,"b","e","b","i",66,6,31,20,19,19,20,21,21,18,15,11,8,36,"T",0.17,"-",0.53,"D",0.77,"D",0.404,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE46!I38","v":0}]
[null,37,37,"E","L","H",5,0,108,0,56,3,7,0,2,"b","e","b","e",75,6,21,6,6,8,11,15,19,23,25,24,21,37,"E",0.14,"-",0.56,"D",0.62,"D",0.394,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE46!I39","v":0}]
[null,38,38,"H","L","H",6,0,36,0,20,1,7,0,1,"b","e","b","i",78,7,17,17,17,18,20,22,22,20,16,12,9,38,"H",0.13,"-",0.46,"-",0.35,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE46!I40","v":0}]
[null,39,39,"N","L","H",5,0,0,0,0,4,7,0,2,"b","b","b","b",76,5,21,32,27,20,16,14,12,9,7,5,3,39,"N",0.13,"-",0.35,"-",0.47,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE46!I41","v":0}]
[null,40,40,"K","L","H",7,0,61,0,30,2,8,0,1,"b","e","b","i",86,3,12,13,14,16,20,23,25,23,17,11,7,40,"K",0.13,"-",0.4,"-",0.33,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G42-delE46!I42","v":0}]
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[null,2806,2772,"A","L","L",5,0,44,0,42,0,1,1,6,"b","e","b","e",19,15,71,12,13,14,16,18,20,21,21,21,20,2772,"A",0.59,"D",0.61,"D",0.92,"D",0.673,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE46!I2808","v":-13}]
[null,2807,2773,"G","L","L",5,0,10,0,12,0,1,1,6,"b","b","b","i",17,15,72,19,19,20,22,21,20,17,15,14,14,2773,"G",0.59,"D",0.53,"D",0.85,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE46!I2809","v":15}]
[null,2808,2774,"S","L","L",4,0,54,0,42,1,2,1,6,"b","e","b","e",23,17,68,15,15,15,17,19,21,22,22,20,18,2774,"S",0.62,"D",0.54,"D",0.73,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE46!I2810","v":-54}]
[null,2809,2775,"F","L","L",2,0,23,0,12,1,2,2,5,"b","b","b","i",28,22,57,20,21,22,24,22,19,15,13,12,11,2775,"F",0.71,"D",0.65,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE46!I2811","v":-23}]
[null,2810,2776,"K","L","L",3,0,86,0,42,1,2,1,5,"b","e","b","e",27,19,61,7,8,9,13,17,21,24,24,21,19,2776,"K",0.66,"D",0.65,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE46!I2812","v":0}]
[null,2811,2777,"R","L","L",0,0,104,0,42,2,4,1,4,"b","e","b","e",45,12,47,6,7,11,16,20,23,25,23,19,16,2777,"R",0.69,"D",0.64,"D",0.86,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE46!I2813","v":-30}]
[null,2812,2778,"N","L","H",0,0,113,0,72,2,5,0,4,"b","e","b","e",53,7,46,4,5,7,10,14,18,22,25,27,27,2778,"N",0.37,"-",0.75,"D",0.83,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE46!I2814","v":0}]
[null,2813,2779,"S","L","H",1,0,93,0,72,1,5,0,3,"b","e","b","e",57,10,42,9,10,11,14,17,19,22,23,24,23,2779,"S",0.29,"-",0.7,"D",0.8,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE46!I2815","v":-21}]
[null,2814,2780,"I","L","H",1,0,70,0,42,0,5,0,4,"b","e","b","e",56,10,46,11,11,13,16,18,20,21,20,20,18,2780,"I",0.43,"-",0.64,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE46!I2816","v":-20}]
[null,2815,2781,"K","L","L",1,0,147,0,72,2,3,1,5,"b","e","b","e",40,14,57,3,4,7,10,14,18,24,26,27,26,2781,"K",0.35,"-",0.8,"D",0.81,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE46!I2817","v":0}]
[null,2816,2782,"K","L","L",3,0,184,0,90,2,2,1,5,"b","e","b","e",31,20,63,2,3,5,7,12,16,22,26,30,31,2782,"K",0.41,"-",0.81,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE46!I2818","v":-37}]
[null,2817,2783,"I","L","L",5,0,152,0,90,0,1,1,6,"b","e","b","e",17,16,74,8,9,12,16,19,19,19,18,19,20,2783,"I",0.35,"-",0.82,"D",0.77,"D",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE46!I2819","v":-132}]
[null,2818,2784,"V","L","L",8,0,127,0,90,3,0,0,9,"b","e","b","e",3,6,93,8,8,7,9,11,13,15,17,25,28,2784,"V",0.36,"-",0.87,"D",0.74,"D",0.541,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE46!I2820","v":0}]
[{"$nulls":54},"SUM:",{"$f":"SUM(BD1:BD2820)","v":4391}]
[{"$nulls":55},{"$f":"SUM(BD2:BD2820)-SUM(BD2255:BD2288)","v":3238}]
[{"$nulls":7},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":7},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":7},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":7},"CSRD"]
[{"$nulls":7},"GRD"]
[{"$nulls":7},"Sec14 & PH"]
[{"$nulls":7},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":5},34,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--(F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))-F2835","v":124},{"$nulls":10},{"$f":"SUMPRODUCT(--(Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820))-F2835","v":132},null,{"$f":"SUMPRODUCT(--(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-F2835","v":275},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BD3:BD2820)>=50))","v":69},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":17},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820) + (S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-F2835","v":333},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":5},{"$f":"F2837/(2818-F2835)","v":{"v":0.04454022988505747,"d":"4%"}},{"$nulls":11},{"$f":"R2838/(2818-F2835)","v":{"v":0.11961206896551724,"d":"12%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=0))>0))-F2835","v":173},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=1))>0))","v":117},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=2))>0))","v":38},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=3))>0))","v":4},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=5))>0))","v":1},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":11},{"$f":"SUMPRODUCT(--((((Q3:Q2820<>Nf1fl!O3:'Nf1fl'!O2820)+(S3:S2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(L3:L2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=0))>0))-F2835","v":84},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=1))>0))","v":26},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=2))>0))","v":12},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=3))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=4))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=5))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=6))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":6},{"$f":"SUMPRODUCT(--((((F3:F2820<>Nf1fl!D3:'Nf1fl'!D2820))*(G3:G2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":21},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":0},{"$f":"COUNTIFS(AR3:AR2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":13}]
[{"$nulls":21},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":31},{"$f":"COUNTIFS(AR3:AR2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":15}]

{"sheet":"delE47","index":12,"n_rows":2864,"n_cols":68,"rows_kept":2250,"cut":true,"merged":[[0,1,0,42],[7,67,12,117],[14,67,20,117],[24,67,30,117],[34,67,36,117],[2288,1,2334,42],[2822,53,2834,54]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
[null,"delE47"]
["No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE46)"]
[1,1,"M","L","L",9,0,169,0,90,4,0,0,9,"b","e","b","e",1,1,96,8,7,7,9,11,13,14,16,24,28,1,"M",0.32,"-",0.99,"D",0.41,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE47!H3","v":0}]
[{"$f":"A3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",8,7,86,6,6,7,10,13,17,19,21,26,28,2,"A",0.22,"-",0.86,"D",0.54,"-",0.576,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE47!H4","v":0}]
[{"$f":"A4+1","v":3},3,"A","L","L",6,0,76,0,72,1,1,0,8,"b","e","b","e",13,7,82,6,7,9,13,16,20,23,24,25,24,3,"A",0.1,"-",0.83,"D",0.36,"-",0.545,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G5-delE47!H5","v":0},{"$nulls":12},"SUMMARY: "]
[4,4,"H","L","L",5,0,132,0,72,3,2,0,6,"b","e","b","e",21,10,72,5,6,7,10,13,17,22,25,29,29,4,"H",0.13,"-",0.84,"D",0.29,"-",0.495,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE47!H6","v":0}]
[5,5,"R","L","L",5,0,104,0,42,3,1,0,7,"b","e","b","e",17,9,76,6,7,10,15,21,25,27,24,20,16,5,"R",0.11,"-",0.7,"D",0.34,"-",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE47!H7","v":0}]
[6,6,"P","L","L",1,0,40,0,30,1,3,0,5,"b","e","b","i",41,6,56,16,16,17,19,21,22,21,18,15,13,6,"P",0.09,"-",0.62,"D",0.34,"-",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE47!H8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (3%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of neurofibromin. Almost all predicted changes in secondary structure have very low or low reliability (RI_S = 0-3), six have medium relibility (RI_S = 4-5) and 3 have high reliability (RI_S = 6-7). One is at (full length NF1) position 2265, the other two are at positions 2243 and 2245, all outside any known domain but close to the deleted exon sequence."]
[7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",68,4,34,13,14,16,19,20,20,19,16,13,10,7,"V",0.22,"-",0.61,"D",0.28,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE47!H9","v":0}]
[8,8,"E","L","H",6,0,108,0,56,2,7,0,1,"b","e","b","e",80,7,17,7,8,9,12,16,20,24,25,21,17,8,"E",0.26,"-",0.54,"D",0.23,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE47!H10","v":0}]
[9,9,"W","L","H",7,0,0,0,0,3,8,0,0,"b","b","b","b",88,4,9,31,28,24,21,18,14,9,5,2,1,9,"W",0.21,"-",0.4,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE47!H11","v":0}]
[10,10,"V","L","H",8,0,0,0,0,8,8,0,0,"b","b","b","b",90,3,8,41,33,19,14,10,7,4,2,1,0,10,"V",0.12,"-",0.31,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE47!H12","v":0}]
[11,11,"Q","L","H",8,0,59,0,30,1,9,0,0,"b","e","b","i",92,1,6,16,16,17,20,22,23,20,14,7,3,11,"Q",0.1,"-",0.28,"-",0.18,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE47!H13","v":0}]
[12,12,"A","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",93,1,6,24,23,21,21,21,19,15,10,5,2,12,"A",0.13,"-",0.27,"-",0.25,"-",0.33,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE47!H14","v":0}]
[13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,46,35,16,9,6,3,2,1,0,0,13,"V",0.11,"-",0.24,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE47!H15","v":0},{"$nulls":12},"2. Solvent Accessibility: 284 residues (10%) are predicted to have changed its classification (according to Pbie/Pbe; b=burried, i=intermediate, e=exposed). All predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-3). NF1delE46 will probably have a solvent accessibility that is further reduced, beyond what can be attributed to the deleted exon. "]
[14,14,"V","L","H",9,0,0,0,0,5,9,0,0,"b","b","b","b",95,1,3,34,29,20,16,12,9,6,4,2,1,14,"V",0.13,"-",0.32,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE47!H16","v":0}]
[15,15,"S","L","H",8,0,54,0,42,3,9,0,0,"b","e","b","e",91,1,7,8,9,11,14,18,22,24,21,14,9,15,"S",0.14,"-",0.41,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE47!H17","v":0}]
[16,16,"R","L","H",7,0,29,0,12,3,8,0,0,"b","b","b","i",89,2,10,15,18,22,26,26,22,16,9,4,2,16,"R",0.14,"-",0.39,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE47!H18","v":0}]
[17,17,"F","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",90,1,9,43,34,20,13,9,6,3,2,1,0,17,"F",0.22,"-",0.4,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE47!H19","v":0}]
[18,18,"D","L","H",7,0,68,0,42,2,8,0,1,"b","e","b","e",88,2,11,12,12,14,17,20,23,24,21,15,11,18,"D",0.25,"-",0.6,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE47!H20","v":0}]
[19,19,"E","L","H",4,0,139,0,72,3,6,0,2,"b","e","b","e",72,3,29,4,5,6,9,12,16,21,25,27,26,19,"E",0.29,"-",0.59,"D",0.55,"-",0.34,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE47!H21","v":0}]
[20,20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",56,4,43,8,10,14,19,23,25,24,20,14,10,20,"Q",0.29,"-",0.6,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE47!H22","v":0}]
[21,21,"L","L","L",6,0,0,0,0,1,1,0,8,"b","b","b","b",14,4,82,29,29,28,25,19,13,8,4,3,2,21,"L",0.31,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE47!H23","v":3}]
[22,22,"P","L","L",7,0,76,0,56,2,1,0,8,"b","e","b","e",11,5,84,12,11,11,13,16,20,24,25,22,20,22,"P",0.37,"-",0.59,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE47!H24","v":0}]
[23,23,"I","L","L",5,0,20,0,12,2,1,1,7,"b","b","b","i",18,13,73,17,20,23,24,22,18,14,11,11,11,23,"I",0.35,"-",0.55,"D",0.66,"D",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE47!H25","v":0},{"$nulls":12},"3. Disorder: 29 residues, predicted to be disordered in the full length protein are predicted to not be disordered in the protein produced by NF1delE46, while 3 residues are predicted to be disordered in the latter but not in neurofibromin. Some of these difference are in isolated single or pairs of residues, instead of longer sequences, with the exception of a 30 residue long sequence (starting at position 2497 in NF1fl) containing 19 residues that are no longer predicted to be disordered. While this stretch of residues is outside the major domains, it could in principle suggest that the exon deletion negatively impacts the protein's flexibility and hinders conformational changes that are necessary for protein function. However, all predictions have very low reliability."]
[24,24,"K","L","L",5,0,114,0,56,2,1,1,6,"b","e","b","e",17,14,71,6,6,9,12,16,20,23,24,22,21,24,"K",0.39,"-",0.57,"D",0.57,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE47!H26","v":0}]
[25,25,"T","L","L",6,0,127,0,90,2,1,0,7,"b","e","b","e",14,10,78,9,9,9,11,13,17,20,23,26,27,25,"T",0.41,"-",0.56,"D",0.5,"-",0.388,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE47!H27","v":-25}]
[26,26,"G","L","L",6,0,10,0,12,0,1,1,7,"b","b","b","i",11,11,80,20,20,20,21,20,19,18,16,15,14,26,"G",0.38,"-",0.49,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE47!H28","v":0}]
[27,27,"Q","L","L",6,0,83,0,42,0,1,1,7,"b","e","b","e",14,11,75,12,12,14,17,19,21,22,22,21,20,27,"Q",0.44,"-",0.57,"D",0.76,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE47!H29","v":0}]
[28,28,"Q","L","L",3,0,83,0,42,0,2,1,5,"b","e","b","e",24,17,61,10,11,13,16,18,20,21,21,21,19,28,"Q",0.48,"-",0.61,"D",0.77,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE47!H30","v":0}]
[29,29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",28,17,61,12,12,13,16,18,20,21,21,20,19,29,"N",0.39,"-",0.6,"D",0.66,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE47!H31","v":0}]
[30,30,"T","L","L",2,0,42,0,30,0,2,1,5,"b","e","b","i",31,16,59,16,16,17,19,19,20,19,17,15,13,30,"T",0.39,"-",0.57,"D",0.66,"D",0.48,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE47!H32","v":-14}]
[31,31,"H","L","L",1,0,77,0,42,1,3,1,5,"b","e","b","e",36,14,55,11,12,13,16,18,20,21,20,18,16,31,"H",0.36,"-",0.6,"D",0.76,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE47!H33","v":0}]
[32,32,"T","L","L",0,0,59,0,42,0,3,1,4,"b","e","b","e",42,13,51,12,12,13,16,17,19,20,20,19,18,32,"T",0.26,"-",0.59,"D",0.7,"D",0.48,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE47!H34","v":0}]
[33,33,"K","L","H",0,0,86,0,42,1,4,1,4,"b","e","b","e",47,13,46,8,9,10,13,16,20,22,22,20,18,33,"K",0.3,"-",0.47,"D",0.68,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE47!H35","v":0},{"$nulls":12},"4. Protein Binding: Deletion of E48 leads to 7 newly predicted potential protein binding sites (GRD: two), while 16 potential binding sites, predicted in full length NF1, are now predicted to be lost in the protein NF1del48 (CSRD: four; GRD: two; ) - in addition to those in the deleted exon."]
[34,34,"V","L","H",1,0,42,0,30,1,5,1,3,"b","e","b","i",54,11,37,15,15,16,19,20,21,19,17,14,12,34,"V",0.24,"-",0.56,"D",0.79,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE47!H36","v":-14}]
[35,35,"S","L","H",2,0,0,0,0,0,5,1,3,"b","b","b","b",60,11,31,19,18,17,18,19,19,19,16,13,10,35,"S",0.21,"-",0.49,"D",0.86,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE47!H37","v":39}]
[36,36,"T","L","H",3,0,28,0,20,0,6,0,2,"b","e","b","i",66,8,28,20,19,19,20,21,21,18,15,10,8,36,"T",0.19,"-",0.53,"D",0.77,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE47!H38","v":0}]
[37,37,"E","L","H",5,0,108,0,56,3,7,0,2,"b","e","b","e",74,7,22,6,6,8,11,15,19,23,25,23,21,37,"E",0.15,"-",0.56,"D",0.62,"D",0.4,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE47!H39","v":0}]
[38,38,"H","L","H",5,0,36,0,20,1,7,0,2,"b","e","b","i",73,7,22,18,17,18,20,22,22,19,15,11,8,38,"H",0.14,"-",0.47,"D",0.35,"-",0.3,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE47!H40","v":0}]
[39,39,"N","L","H",4,0,0,0,0,4,7,0,2,"b","b","b","b",73,6,24,32,27,20,16,14,12,9,7,5,4,39,"N",0.13,"-",0.36,"-",0.47,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE47!H41","v":0}]
[40,40,"K","L","H",7,0,61,0,30,3,8,0,1,"b","e","b","i",85,4,14,13,13,15,19,23,25,23,18,12,8,40,"K",0.16,"-",0.41,"-",0.33,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G42-delE47!H42","v":0}]
[41,41,"E","L","H",7,0,81,0,42,1,8,0,1,"b","e","b","e",84,4,13,13,13,14,17,19,22,23,21,18,14,41,"E",0.16,"-",0.46,"-",0.36,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G43-delE47!H43","v":0}]
[42,42,"C","L","H",6,0,0,0,0,3,7,1,1,"b","b","b","b",78,11,13,30,27,23,20,17,13,10,6,3,2,42,"C",0.19,"-",0.3,"-",0.41,"-",0.28,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G44-delE47!H44","v":0}]
[43,43,"L","L","H",5,0,0,0,0,8,7,1,1,"b","b","b","b",74,17,14,42,33,19,13,10,7,5,3,2,1,43,"L",0.19,"-",0.28,"-",0.32,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G45-delE47!H45","v":0}]
[44,44,"I","L","H",5,0,0,0,0,3,6,1,1,"b","b","b","b",68,18,18,31,28,22,18,15,12,9,6,4,3,44,"I",0.11,"-",0.4,"-",0.4,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G46-delE47!H46","v":0}]
[45,45,"N","L","H",4,0,47,0,30,1,6,1,2,"b","e","b","i",67,15,23,17,17,17,19,21,22,20,16,11,9,45,"N",0.08,"-",0.4,"-",0.21,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G47-delE47!H47","v":0}]
[46,46,"I","L","H",3,0,0,0,0,5,6,1,2,"b","b","b","b",63,12,29,36,31,23,17,13,9,6,4,2,2,46,"I",0.08,"-",0.41,"-",0.2,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G48-delE47!H48","v":0}]
[47,47,"S","L","H",1,0,0,0,0,4,5,0,4,"b","b","b","b",53,8,43,33,28,22,18,15,12,9,7,5,4,47,"S",0.06,"-",0.44,"-",0.19,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G49-delE47!H49","v":0}]
[48,48,"K","L","H",2,0,86,0,42,1,6,0,3,"b","e","b","e",64,6,35,14,14,14,16,19,21,23,22,19,17,48,"K",0.07,"-",0.58,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G50-delE47!H50","v":0}]
[49,49,"Y","L","H",0,0,13,0,6,2,5,0,4,"b","b","b","b",53,6,45,22,23,24,23,21,17,12,9,7,6,49,"Y",0.09,"-",0.51,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G51-delE47!H51","v":13}]
[50,50,"K","L","H",2,0,41,0,20,1,5,0,3,"b","e","b","i",59,6,39,16,16,17,19,21,21,18,14,9,6,50,"K",0.11,"-",0.47,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G52-delE47!H52","v":0}]
[51,51,"F","L","H",5,0,0,0,0,4,7,0,2,"b","b","b","b",75,4,23,33,30,23,19,15,11,8,5,3,2,51,"F",0.13,"-",0.35,"-",0.26,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G53-delE47!H53","v":0}]
[52,52,"S","L","H",7,0,0,0,0,2,8,0,1,"b","b","b","b",85,3,15,26,23,20,18,17,16,13,10,7,5,52,"S",0.11,"-",0.34,"-",0.18,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G54-delE47!H54","v":0}]
[53,53,"L","L","H",8,0,0,0,0,4,8,0,0,"b","b","b","b",91,3,8,32,27,19,16,14,11,8,5,3,2,53,"L",0.15,"-",0.29,"-",0.15,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G55-delE47!H55","v":0}]
[54,54,"V","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",94,2,5,46,36,17,11,7,4,2,1,0,0,54,"V",0.1,"-",0.27,"-",0.18,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G56-delE47!H56","v":0}]
[55,55,"I","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,2,4,43,34,16,10,7,4,2,1,0,0,55,"I",0.07,"-",0.27,"-",0.13,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G57-delE47!H57","v":0}]
[56,56,"S","L","H",8,0,0,0,0,2,9,0,0,"b","b","b","b",94,1,5,26,24,20,18,17,15,11,8,4,3,56,"S",0.08,"-",0.33,"-",0.13,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G58-delE47!H58","v":0}]
[57,57,"G","L","H",8,0,0,0,0,5,9,0,0,"b","b","b","b",93,1,6,34,28,19,15,12,10,7,4,2,1,57,"G",0.08,"-",0.25,"-",0.14,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G59-delE47!H59","v":0}]
[58,58,"L","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,0,3,47,36,15,8,5,3,1,0,0,0,58,"L",0.08,"-",0.26,"-",0.18,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G60-delE47!H60","v":0}]
[59,59,"T","L","H",9,0,0,0,0,3,9,0,0,"b","b","b","b",95,1,3,28,25,20,18,16,13,9,6,3,2,59,"T",0.1,"-",0.34,"-",0.18,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G61-delE47!H61","v":0}]
[60,60,"T","L","H",8,0,42,0,30,3,9,0,0,"b","e","b","i",92,2,7,11,12,14,18,21,24,23,17,10,6,60,"T",0.14,"-",0.41,"-",0.24,"-",0.28,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G62-delE47!H62","v":0}]
[61,61,"I","L","H",8,0,0,0,0,4,9,0,0,"b","b","b","b",92,1,7,32,28,21,18,15,11,7,3,1,0,61,"I",0.16,"-",0.35,"-",0.24,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G63-delE47!H63","v":0}]
[62,62,"L","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",93,1,5,44,34,18,11,7,4,3,2,1,0,62,"L",0.18,"-",0.37,"-",0.19,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G64-delE47!H64","v":0}]
[63,63,"K","L","H",8,0,114,0,56,3,9,0,0,"b","e","b","e",90,1,9,6,6,8,11,15,21,26,27,20,15,63,"K",0.15,"-",0.52,"D",0.28,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G65-delE47!H65","v":0}]
[64,64,"N","L","H",6,0,47,0,30,2,8,0,1,"b","e","b","i",80,2,18,11,12,14,18,21,23,22,18,13,9,64,"N",0.23,"-",0.59,"D",0.21,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G66-delE47!H66","v":0}]
[65,65,"V","L","H",4,0,0,0,0,4,6,0,2,"b","b","b","b",69,3,29,34,30,23,19,15,10,6,4,2,2,65,"V",0.3,"-",0.52,"D",0.16,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G67-delE47!H67","v":0}]
[66,66,"N","L","H",2,0,65,0,42,1,5,0,3,"b","e","b","e",62,4,42,16,16,16,18,20,21,22,21,18,16,66,"N",0.3,"-",0.56,"D",0.2,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G68-delE47!H68","v":0}]
[{"$f":"A68+1","v":67},67,"N","L","L",0,0,87,0,56,3,4,0,5,"b","e","b","e",49,5,55,4,5,7,10,14,19,24,27,26,23,67,"N",0.34,"-",0.65,"D",0.33,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G69-delE47!H69","v":0}]
[68,68,"M","L","L",2,0,22,0,12,1,3,0,5,"b","b","b","i",34,9,63,17,18,21,22,21,18,15,13,12,11,68,"M",0.35,"-",0.65,"D",0.24,"-",0.364,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G70-delE47!H70","v":34}]
[69,69,"R","L","L",4,0,104,0,42,1,2,1,6,"b","e","b","e",26,14,70,9,10,12,15,19,21,23,23,21,19,69,"R",0.42,"-",0.62,"D",0.22,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G71-delE47!H71","v":0}]
[70,70,"I","L","L",5,0,33,0,20,0,1,1,6,"b","e","b","i",20,14,74,12,13,15,18,20,20,20,19,19,18,70,"I",0.42,"-",0.64,"D",0.32,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G72-delE47!H72","v":0}]
[71,71,"F","L","L",6,0,59,0,30,0,1,1,7,"b","e","b","i",15,11,78,10,11,14,17,19,20,20,19,19,18,71,"F",0.42,"-",0.64,"D",0.41,"-",0.374,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G73-delE47!H73","v":0}]
[72,72,"G","L","L",6,0,75,0,90,1,1,0,7,"b","e","b","e",15,9,79,9,10,12,14,16,19,21,22,24,25,72,"G",0.44,"-",0.69,"D",0.41,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G74-delE47!H74","v":-15}]
[73,73,"E","L","L",5,0,139,0,72,2,1,0,7,"b","e","b","e",20,10,74,5,6,8,12,14,18,21,24,27,27,73,"E",0.43,"-",0.71,"D",0.39,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G75-delE47!H75","v":0}]
[74,74,"A","L","L",5,0,95,0,90,1,1,0,7,"b","e","b","e",19,10,73,9,10,12,15,17,19,20,22,23,24,74,"A",0.36,"-",0.71,"D",0.27,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G76-delE47!H76","v":-64}]
[75,75,"A","L","L",5,0,21,0,20,0,1,0,7,"b","e","b","i",20,10,73,12,13,15,18,21,21,21,18,16,14,75,"A",0.35,"-",0.62,"D",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G77-delE47!H77","v":0}]
[76,76,"E","L","L",2,0,139,0,72,1,3,0,5,"b","e","b","e",35,8,64,7,8,9,12,15,19,22,23,25,25,76,"E",0.29,"-",0.62,"D",0.4,"-",0.31,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G78-delE47!H78","v":0}]
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[1971,1971,"I","L","H",7,0,0,0,0,2,8,0,1,"b","b","b","b",86,3,11,28,25,21,20,18,14,10,6,4,2,1971,"I",0.13,"-",0.41,"-",0.19,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1973-delE47!H1973","v":0}]
[1972,1972,"Q","L","H",8,0,0,0,0,5,9,0,0,"b","b","b","b",91,2,7,34,29,19,16,13,9,6,4,2,1,1972,"Q",0.12,"-",0.38,"-",0.25,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1974-delE47!H1974","v":0}]
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[1977,1977,"G","L","H",8,0,0,0,0,2,9,0,0,"b","b","b","b",92,3,7,24,22,18,17,17,16,14,12,8,5,1977,"G",0.14,"-",0.39,"-",0.19,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1979-delE47!H1979","v":0}]
[1978,1978,"S","L","H",7,0,0,0,0,1,8,0,1,"b","b","b","b",88,3,11,24,23,20,20,19,17,14,10,7,6,1978,"S",0.1,"-",0.43,"-",0.24,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1980-delE47!H1980","v":39}]
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[1984,1984,"D","L","L",3,0,91,0,56,3,2,0,6,"b","e","b","e",32,5,70,5,5,6,9,13,18,23,26,26,26,1984,"D",0.15,"-",0.6,"D",0.15,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1986-delE47!H1986","v":0}]
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[1988,1988,"V","L","H",7,0,0,0,0,1,8,0,1,"b","b","b","b",82,8,12,25,24,22,21,19,16,11,7,4,2,1988,"V",0.13,"-",0.32,"-",0.14,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1990-delE47!H1990","v":0}]
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[2774,2727,"D","L","L",4,0,68,0,42,0,2,1,6,"b","e","b","e",24,12,70,9,10,11,14,17,21,23,23,23,22,2727,"D",0.75,"D",0.66,"D",0.75,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2776-delE47!H2776","v":0}]
[2775,2728,"K","L","L",3,0,147,0,72,1,2,1,6,"b","e","b","e",27,12,66,6,7,10,13,16,19,21,22,23,23,2728,"K",0.75,"D",0.69,"D",0.75,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2777-delE47!H2777","v":0}]
[2776,2729,"E","L","L",5,0,139,0,72,1,2,1,6,"b","e","b","e",21,12,71,7,7,9,12,15,19,21,23,24,24,2729,"E",0.73,"D",0.65,"D",0.75,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2778-delE47!H2778","v":0}]
[2777,2730,"N","L","L",5,0,65,0,42,0,1,1,7,"b","e","b","e",16,12,75,9,10,12,15,18,21,22,22,20,19,2730,"N",0.66,"D",0.56,"D",0.77,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2779-delE47!H2779","v":0}]
[2778,2731,"V","L","L",5,0,28,0,20,1,1,1,6,"b","e","b","i",18,14,73,16,16,18,20,21,20,18,16,14,12,2731,"V",0.66,"D",0.57,"D",0.86,"D",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2780-delE47!H2780","v":0}]
[2779,2732,"E","L","L",5,0,108,0,56,1,1,1,6,"b","e","b","e",20,17,70,8,8,11,14,17,20,22,23,23,22,2732,"E",0.62,"D",0.64,"D",0.79,"D",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2781-delE47!H2781","v":-27}]
[2780,2733,"L","L","L",4,0,118,0,72,0,2,1,6,"b","e","b","e",24,17,66,11,12,13,15,17,19,21,21,22,22,2733,"L",0.64,"D",0.54,"D",0.64,"D",0.582,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2782-delE47!H2782","v":-50}]
[2781,2734,"S","L","L",5,0,15,0,12,1,1,1,7,"b","b","b","i",14,17,74,19,20,21,23,22,20,16,14,12,11,2734,"S",0.62,"D",0.53,"D",0.44,"-",0.576,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2783-delE47!H2783","v":0}]
[2782,2735,"P","L","L",6,0,97,0,72,0,1,1,7,"b","e","b","e",15,15,75,15,15,15,17,18,20,21,21,22,21,2735,"P",0.58,"D",0.53,"D",0.44,"-",0.616,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2784-delE47!H2784","v":-81}]
[2783,2736,"T","L","L",6,0,17,0,12,0,1,1,7,"b","b","b","i",11,14,79,20,20,20,22,21,20,17,15,13,11,2736,"T",0.58,"D",0.46,"-",0.54,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2785-delE47!H2785","v":-17}]
[2784,2737,"T","L","L",5,0,0,0,0,0,1,1,6,"b","b","b","b",17,14,72,20,20,19,20,20,19,17,15,13,12,2737,"T",0.63,"D",0.49,"D",0.44,"-",0.582,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2786-delE47!H2786","v":0}]
[2785,2738,"G","L","L",5,0,35,0,42,1,1,1,6,"b","e","b","e",19,14,72,14,15,15,18,20,21,22,21,19,17,2738,"G",0.67,"D",0.5,"D",0.6,"D",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2787-delE47!H2787","v":-10}]
[2786,2739,"H","L","L",4,0,55,0,30,1,2,1,6,"b","e","b","i",24,16,67,14,15,17,20,21,22,20,18,17,16,2739,"H",0.7,"D",0.49,"D",0.57,"-",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2788-delE47!H2788","v":0}]
[2787,2740,"C","L","L",5,0,27,0,20,0,1,1,7,"b","e","b","i",20,11,74,15,15,17,19,20,20,18,17,16,15,2740,"C",0.69,"D",0.49,"D",0.57,"-",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2789-delE47!H2789","v":0}]
[2788,2741,"N","L","L",6,0,141,0,90,1,1,0,7,"b","e","b","e",14,10,78,9,10,11,13,15,18,20,21,24,25,2741,"N",0.7,"D",0.47,"D",0.55,"-",0.602,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2790-delE47!H2790","v":0}]
[2789,2742,"S","L","L",6,0,39,0,30,0,1,1,7,"b","e","b","i",12,12,79,14,14,16,19,20,21,20,18,18,17,2742,"S",0.65,"D",0.52,"D",0.52,"-",0.606,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2791-delE47!H2791","v":54}]
[2790,2743,"G","L","L",6,0,25,0,30,0,1,1,7,"b","e","b","i",12,12,78,14,14,16,18,20,21,21,19,18,17,2743,"G",0.46,"-",0.42,"-",0.57,"-",0.596,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2792-delE47!H2792","v":0}]
[2791,2744,"R","L","L",5,0,49,0,20,1,1,1,6,"b","e","b","i",14,18,72,15,16,18,20,22,22,20,17,14,12,2744,"R",0.48,"-",0.51,"D",0.59,"D",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2793-delE47!H2793","v":0}]
[2792,2745,"T","L","L",5,0,28,0,20,0,1,1,6,"b","e","b","i",20,16,71,18,18,18,20,21,21,19,17,14,13,2745,"T",0.56,"D",0.49,"D",0.74,"D",0.622,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2794-delE47!H2794","v":0}]
[2793,2746,"R","L","L",5,0,29,0,12,0,1,1,6,"b","b","b","i",18,18,71,20,21,21,22,21,20,16,13,9,8,2746,"R",0.57,"D",0.42,"-",0.76,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2795-delE47!H2795","v":0}]
[2794,2747,"H","L","L",5,0,0,0,0,0,1,1,6,"b","b","b","b",17,18,71,22,22,21,21,20,18,15,12,10,9,2747,"H",0.6,"D",0.45,"-",0.66,"D",0.602,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2796-delE47!H2796","v":0}]
[2795,2748,"G","L","L",4,0,10,0,12,0,2,1,6,"b","b","b","i",22,16,69,21,21,21,22,21,20,18,15,12,10,2748,"G",0.59,"D",0.49,"D",0.73,"D",0.606,3,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2797-delE47!H2797","v":0}]
[2796,2749,"S","L","L",3,0,0,0,0,0,2,1,6,"b","b","b","b",28,14,67,23,22,20,20,20,19,17,14,12,10,2749,"S",0.65,"D",0.43,"-",0.83,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2798-delE47!H2798","v":0}]
[2797,2750,"A","L","H",1,0,0,0,0,1,5,0,4,"b","b","b","b",57,9,44,24,23,20,20,20,18,16,15,13,12,2750,"A",0.71,"D",0.36,"-",0.87,"D",0.616,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2799-delE47!H2799","v":0}]
[2798,2751,"S","L","H",0,0,72,0,56,1,4,0,4,"b","e","b","e",53,9,48,11,11,12,15,18,20,22,23,22,21,2751,"S",0.69,"D",0.56,"D",0.87,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2800-delE47!H2800","v":-33}]
[2799,2752,"Q","L","H",0,0,83,0,42,1,4,0,4,"b","e","b","e",50,10,46,10,11,14,18,21,23,24,22,19,16,2752,"Q",0.7,"D",0.62,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE47!H2801","v":0}]
[2800,2753,"V","L","L",1,0,0,0,0,0,3,1,5,"b","b","b","b",38,14,54,21,21,20,21,20,18,15,12,11,10,2753,"V",0.67,"D",0.61,"D",0.91,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE47!H2802","v":28}]
[2801,2754,"Q","L","L",3,0,83,0,42,1,2,1,5,"b","e","b","e",29,18,62,14,14,15,18,20,22,23,21,18,16,2754,"Q",0.67,"D",0.67,"D",0.88,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE47!H2803","v":0}]
[2802,2755,"K","L","L",4,0,147,0,72,2,2,1,6,"b","e","b","e",23,17,69,7,7,9,12,16,20,24,26,27,26,2755,"K",0.69,"D",0.69,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE47!H2804","v":0}]
[2803,2756,"Q","L","L",5,0,83,0,42,1,1,1,6,"b","e","b","e",20,16,74,8,9,12,16,20,22,23,23,21,19,2756,"Q",0.6,"D",0.6,"D",0.79,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE47!H2805","v":27}]
[2804,2757,"R","L","L",6,0,104,0,42,0,1,1,7,"b","e","b","e",17,13,77,10,11,13,16,19,21,22,22,22,21,2757,"R",0.65,"D",0.66,"D",0.87,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE47!H2806","v":34}]
[2805,2758,"S","L","L",6,0,39,0,30,1,1,1,7,"b","e","b","i",14,11,80,13,14,16,20,22,23,22,20,18,17,2758,"S",0.66,"D",0.63,"D",0.93,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE47!H2807","v":-13}]
[2806,2759,"A","L","L",5,0,76,0,72,1,1,0,7,"b","e","b","e",20,9,76,10,11,11,14,16,18,20,21,24,24,2759,"A",0.66,"D",0.66,"D",0.92,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE47!H2808","v":-45}]
[2807,2760,"G","L","L",5,0,10,0,12,0,1,1,7,"b","b","b","i",20,11,75,20,20,19,21,21,20,18,17,15,14,2760,"G",0.62,"D",0.58,"D",0.85,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE47!H2809","v":15}]
[2808,2761,"S","L","L",4,0,0,0,0,0,2,1,6,"b","b","b","b",24,13,72,20,19,19,20,20,20,19,18,17,15,2761,"S",0.63,"D",0.56,"D",0.73,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE47!H2810","v":0}]
[2809,2762,"F","L","L",2,0,0,0,0,0,2,1,5,"b","b","b","b",30,21,58,24,24,22,22,20,17,13,11,9,9,2762,"F",0.72,"D",0.64,"D",0.83,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE47!H2811","v":0}]
[2810,2763,"K","L","L",3,0,86,0,42,0,2,1,5,"b","e","b","e",29,18,59,8,8,9,13,17,21,23,23,21,20,2763,"K",0.66,"D",0.59,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE47!H2812","v":0}]
[2811,2764,"R","L","L",0,0,74,0,30,1,4,1,4,"b","e","b","i",44,16,49,9,11,14,19,22,24,23,21,18,16,2764,"R",0.71,"D",0.61,"D",0.86,"D",0.653,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE47!H2813","v":0}]
[2812,2765,"N","L","L",0,0,87,0,56,1,4,1,4,"b","e","b","e",47,11,52,7,8,10,14,17,20,22,23,23,23,2765,"N",0.38,"-",0.72,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE47!H2814","v":26}]
[2813,2766,"S","L","L",0,0,72,0,56,1,4,1,3,"b","e","b","e",56,15,43,10,11,13,16,18,20,22,23,22,21,2766,"S",0.27,"-",0.59,"D",0.8,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE47!H2815","v":0}]
[2814,2767,"I","L","L",0,0,50,0,30,0,4,1,4,"b","e","b","i",53,16,46,13,14,15,17,19,20,20,20,19,18,2767,"I",0.43,"-",0.59,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE47!H2816","v":0}]
[2815,2768,"K","L","L",0,0,147,0,72,3,3,1,4,"b","e","b","e",43,20,50,3,3,6,9,14,18,23,27,28,28,2768,"K",0.36,"-",0.68,"D",0.81,"D",0.653,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE47!H2817","v":0}]
[2816,2769,"K","L","L",2,0,147,0,72,2,2,2,4,"b","e","b","e",31,27,55,4,5,7,10,14,18,23,26,27,27,2769,"K",0.4,"-",0.79,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE47!H2818","v":0}]
[2817,2770,"I","L","L",3,0,152,0,90,0,1,2,5,"b","e","b","e",18,25,63,9,10,12,15,17,18,18,18,19,20,2770,"I",0.37,"-",0.77,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE47!H2819","v":-132}]
[2818,2771,"V","L","L",8,0,127,0,90,4,0,0,8,"b","e","b","e",3,8,91,4,4,5,7,9,12,16,19,28,32,2771,"V",0.3,"-",0.84,"D",0.74,"D",0.545,1,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE47!H2820","v":0}]
[{"$nulls":53},"SUM:",{"$f":"SUM(BC1:BC2820)","v":5356}]
[{"$nulls":54},{"$f":"SUM(BC2:BC2820)-SUM(BC2289:BC2335)","v":3918}]
[{"$nulls":6},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":6},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":6},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":6},"CSRD"]
[{"$nulls":6},"GRD"]
[{"$nulls":6},"Sec14 & PH"]
[{"$nulls":6},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":4},47,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":4},{"$f":"SUMPRODUCT(--(E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))-E2835","v":93},{"$nulls":10},{"$f":"SUMPRODUCT(--(P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820))-E2835","v":128},null,{"$f":"SUMPRODUCT(--(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-E2835","v":237},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BC3:BC2820)>=50))","v":54},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":16},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820) + (R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-E2835","v":284},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":4},{"$f":"E2837/(2818-E2835)","v":{"v":0.03356189101407434,"d":"3%"}},{"$nulls":11},{"$f":"Q2838/(2818-E2835)","v":{"v":0.10249007578491519,"d":"10%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=0))>0))-E2835","v":146},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=1))>0))","v":101},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=2))>0))","v":33},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=3))>0))","v":4},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=0))>0))-E2835","v":62},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=1))>0))","v":17},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=2))>0))","v":2},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=3))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=4))>0))","v":5},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=5))>0))","v":1},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=6))>0))","v":3},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":20},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AP3:AP2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":3},{"$f":"COUNTIFS(AQ3:AQ2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":7}]
[{"$nulls":20},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AP3:AP2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":29},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":16}]

{"sheet":"delE52","index":13,"n_rows":2864,"n_cols":68,"rows_kept":2250,"cut":true,"merged":[[0,1,0,42],[7,67,10,117],[14,67,20,117],[24,67,28,117],[32,67,35,117],[2519,1,2559,42],[2822,53,2834,54]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
[null,"delE52"]
["No (NF1fl)","No","AA","OHEL","PHEL","RI_S","OACC","PACC","OREL","PREL","RI_A","pH","pE","pL","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9","Number ","Residue ","NORSnet ","NORS2st ","PROFbval ","bval2st ","Ucon ","Ucon2st ","MD_raw   ","MD_rel  ","MD2st ","Protein binding",{"$nulls":11},"PACC(Nf1fl) - PACC(delE51)"]
[1,1,"M","L","L",9,0,169,0,90,4,0,0,9,"b","e","b","e",1,1,96,8,7,7,9,11,13,14,16,25,29,1,"M",0.32,"-",0.99,"D",0.41,"-",0.596,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G3-delE52!H3","v":0}]
[{"$f":"A3+1","v":2},2,"A","L","L",7,0,95,0,90,2,0,0,8,"b","e","b","e",8,7,86,6,6,7,10,13,16,19,21,26,28,2,"A",0.21,"-",0.86,"D",0.54,"-",0.586,2,"D","P",{"$nulls":11},{"$f":"Nf1fl!G4-delE52!H4","v":0}]
[{"$f":"A4+1","v":3},3,"A","L","L",7,0,76,0,72,1,1,0,8,"b","e","b","e",13,7,83,7,8,9,13,16,20,22,23,25,24,3,"A",0.09,"-",0.83,"D",0.36,"-",0.556,1,"D","P",{"$nulls":11},{"$f":"Nf1fl!G5-delE52!H5","v":0},{"$nulls":12},"SUMMARY: "]
[4,4,"H","L","L",5,0,132,0,72,2,1,1,7,"b","e","b","e",20,11,73,7,7,9,13,16,19,22,24,26,25,4,"H",0.12,"-",0.84,"D",0.29,"-",0.505,0,"-","P",{"$nulls":11},{"$f":"Nf1fl!G6-delE52!H6","v":0}]
[5,5,"R","L","L",6,0,104,0,42,3,1,0,7,"b","e","b","e",15,9,77,6,7,10,15,20,25,27,24,20,16,5,"R",0.1,"-",0.7,"D",0.34,"-",0.455,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G7-delE52!H7","v":0}]
[6,6,"P","L","L",1,0,40,0,30,1,4,0,5,"b","e","b","i",41,5,56,16,16,17,19,21,22,21,18,15,12,6,"P",0.08,"-",0.62,"D",0.34,"-",0.424,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G8-delE52!H8","v":0},{"$nulls":12},"1. Secondary Structure: Only a small percentage of residues (3%) has a different predicted secondary structure (according to PHEL) compared to the prediction for residues of neurofibromin. Almost all predicted changes in secondary structure have very low reliability (RI_S = 0-1), the remaining two have low relibility (RI_S = 2). "]
[7,7,"V","L","H",3,0,28,0,20,1,6,0,3,"b","e","b","i",68,4,33,13,14,16,19,20,20,19,16,12,10,7,"V",0.2,"-",0.6,"D",0.28,"-",0.354,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G9-delE52!H9","v":0}]
[8,8,"E","L","H",6,0,108,0,56,2,7,0,1,"b","e","b","e",81,6,15,7,7,9,12,16,20,24,25,21,17,8,"E",0.25,"-",0.54,"D",0.23,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G10-delE52!H10","v":0}]
[9,9,"W","L","H",8,0,0,0,0,3,8,0,0,"b","b","b","b",89,3,8,31,28,24,21,18,14,9,5,2,1,9,"W",0.21,"-",0.4,"-",0.26,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G11-delE52!H11","v":0}]
[10,10,"V","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",91,3,6,41,33,19,14,10,7,4,2,1,0,10,"V",0.12,"-",0.32,"-",0.26,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G12-delE52!H12","v":0}]
[11,11,"Q","L","H",8,0,59,0,30,1,9,0,0,"b","e","b","i",93,1,5,16,16,17,20,22,23,20,14,7,3,11,"Q",0.1,"-",0.28,"-",0.18,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G13-delE52!H13","v":0}]
[12,12,"A","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",93,1,6,24,23,21,21,21,19,15,10,5,2,12,"A",0.13,"-",0.27,"-",0.25,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G14-delE52!H14","v":0}]
[13,13,"V","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",94,1,4,47,35,16,9,6,3,2,1,0,0,13,"V",0.11,"-",0.24,"-",0.25,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G15-delE52!H15","v":0},{"$nulls":12},"2. Solvent Accessibility: 240 residues (9%) are predicted to have changed its classification (according to Pbie/Pbe; b=burried, i=intermediate, e=exposed). All predicted changes of solvent accessibility have very low or low reliability (RI_A = 0-3). NF1delE51's overall solvent accessibility is probably not reduced that much further, aside from the lost solvent accessibility attributed to the deleted exon. "]
[14,14,"V","L","H",9,0,0,0,0,4,9,0,0,"b","b","b","b",95,1,3,33,29,21,17,14,10,7,4,2,1,14,"V",0.12,"-",0.32,"-",0.37,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G16-delE52!H16","v":0}]
[15,15,"S","L","H",8,0,54,0,42,3,9,0,0,"b","e","b","e",91,1,8,8,9,10,14,18,22,24,21,14,9,15,"S",0.14,"-",0.42,"-",0.33,"-",0.35,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G17-delE52!H17","v":0}]
[16,16,"R","L","H",7,0,29,0,12,3,8,0,0,"b","b","b","i",89,2,10,15,17,22,26,26,22,16,9,4,2,16,"R",0.14,"-",0.39,"-",0.33,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G18-delE52!H18","v":0}]
[17,17,"F","L","H",8,0,0,0,0,8,9,0,0,"b","b","b","b",90,1,9,42,34,21,13,9,6,4,2,1,0,17,"F",0.21,"-",0.41,"-",0.26,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G19-delE52!H19","v":0}]
[18,18,"D","L","H",7,0,68,0,42,2,8,0,1,"b","e","b","e",88,2,11,12,12,14,17,20,23,24,21,15,11,18,"D",0.24,"-",0.6,"D",0.44,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G20-delE52!H20","v":0}]
[19,19,"E","L","H",4,0,139,0,72,3,6,0,2,"b","e","b","e",71,3,29,4,5,6,9,12,16,21,25,27,26,19,"E",0.28,"-",0.6,"D",0.55,"-",0.333,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G21-delE52!H21","v":0}]
[20,20,"Q","L","H",1,0,59,0,30,3,5,0,4,"b","e","b","i",56,4,43,8,10,14,19,23,25,24,20,14,10,20,"Q",0.28,"-",0.6,"D",0.49,"-",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G22-delE52!H22","v":0}]
[21,21,"L","L","L",6,0,3,0,2,3,1,0,8,"b","b","b","b",14,4,82,28,29,28,25,19,13,8,5,3,2,21,"L",0.31,"-",0.59,"D",0.5,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G23-delE52!H23","v":0}]
[22,22,"P","L","L",7,0,76,0,56,2,1,0,8,"b","e","b","e",11,6,84,12,11,11,13,16,20,24,25,23,20,22,"P",0.36,"-",0.59,"D",0.71,"D",0.323,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G24-delE52!H24","v":0}]
[23,23,"I","L","L",5,0,20,0,12,2,1,1,6,"b","b","b","i",17,14,72,17,20,23,24,22,18,14,12,11,11,23,"I",0.35,"-",0.54,"D",0.66,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G25-delE52!H25","v":0},{"$nulls":12},"3. Disorder: 18 residues, predicted to be disordered in the full length protein are predicted to not be disordered in the protein produced by NF1delE51, while 3 residues are predicted to be disordered in the latter but not in neurofibromin. Most of these differences are in isolated single or pairs of residues, instead of longer sequences. And all predictions have very low or low reliability."]
[24,24,"K","L","L",5,0,114,0,56,3,1,1,6,"b","e","b","e",18,15,70,4,5,7,10,14,18,23,26,26,25,24,"K",0.38,"-",0.56,"D",0.57,"-",0.343,5,"-","-",{"$nulls":11},{"$f":"Nf1fl!G26-delE52!H26","v":0}]
[25,25,"T","L","L",6,0,127,0,90,2,1,1,7,"b","e","b","e",14,11,76,9,9,9,11,14,17,20,23,26,27,25,"T",0.39,"-",0.56,"D",0.5,"-",0.388,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G27-delE52!H27","v":-25}]
[26,26,"G","L","L",6,0,10,0,12,0,0,1,7,"b","b","b","i",10,12,81,19,19,20,21,20,19,18,16,15,14,26,"G",0.38,"-",0.49,"D",0.66,"D",0.444,2,"-","-",{"$nulls":11},{"$f":"Nf1fl!G28-delE52!H28","v":0}]
[27,27,"Q","L","L",6,0,83,0,42,0,1,1,7,"b","e","b","e",13,12,74,11,12,14,17,19,21,22,22,21,20,27,"Q",0.42,"-",0.57,"D",0.76,"D",0.475,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G29-delE52!H29","v":0}]
[28,28,"Q","L","L",3,0,110,0,56,1,2,1,6,"b","e","b","e",22,17,61,10,11,13,16,18,20,21,22,21,20,28,"Q",0.49,"-",0.62,"D",0.77,"D",0.505,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G30-delE52!H30","v":-27}]
[29,29,"N","L","L",3,0,65,0,42,0,2,1,5,"b","e","b","e",28,18,59,12,12,13,16,18,20,21,21,20,19,29,"N",0.39,"-",0.6,"D",0.66,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G31-delE52!H31","v":0}]
[30,30,"T","L","L",2,0,42,0,30,0,2,1,5,"b","e","b","i",30,17,56,16,16,17,19,19,20,19,17,14,12,30,"T",0.37,"-",0.56,"D",0.66,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G32-delE52!H32","v":-14}]
[31,31,"H","L","L",1,0,77,0,42,1,3,1,5,"b","e","b","e",36,15,54,11,12,14,17,18,20,21,20,18,16,31,"H",0.34,"-",0.59,"D",0.76,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G33-delE52!H33","v":0},{"$nulls":12},"4. Protein Binding: Deletion of E51 leads to 6 newly predicted potential protein binding sites (CSRD: one; Syndecans: one; Sec14&PH: one), while 14 potential binding sites, predicted in full length NF1, are now predicted to be lost in the protein NF1del51 (CSRD: two; GRD: three; ) - in addition to those in the deleted exon."]
[32,32,"T","L","L",1,0,59,0,42,0,3,1,4,"b","e","b","e",40,15,51,12,12,13,16,17,19,20,20,19,18,32,"T",0.26,"-",0.58,"D",0.7,"D",0.485,1,"-","-",{"$nulls":11},{"$f":"Nf1fl!G34-delE52!H34","v":0}]
[33,33,"K","L","L",0,0,86,0,42,1,4,1,4,"b","e","b","e",43,14,48,8,9,10,13,16,20,22,22,20,18,33,"K",0.3,"-",0.46,"-",0.68,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G35-delE52!H35","v":0}]
[34,34,"V","L","H",1,0,42,0,30,1,5,1,3,"b","e","b","i",53,12,37,15,15,16,19,20,21,20,18,15,12,34,"V",0.25,"-",0.56,"D",0.79,"D",0.515,0,"-","-",{"$nulls":11},{"$f":"Nf1fl!G36-delE52!H36","v":-14}]
[35,35,"S","L","H",2,0,26,0,20,0,5,0,3,"b","e","b","i",58,10,34,18,17,16,18,19,19,19,17,14,12,35,"S",0.2,"-",0.49,"D",0.86,"D",0.424,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G37-delE52!H37","v":13}]
[36,36,"T","L","H",3,0,28,0,20,0,6,0,2,"b","e","b","i",66,7,30,19,19,19,20,21,21,18,15,11,8,36,"T",0.18,"-",0.54,"D",0.77,"D",0.414,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G38-delE52!H38","v":0}]
[37,37,"E","L","H",5,0,108,0,56,3,7,0,2,"b","e","b","e",74,7,21,6,6,8,11,14,18,23,25,24,21,37,"E",0.14,"-",0.56,"D",0.62,"D",0.404,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G39-delE52!H39","v":0}]
[38,38,"H","L","H",5,0,36,0,20,1,7,0,2,"b","e","b","i",73,8,21,17,17,18,20,22,22,20,16,12,9,38,"H",0.13,"-",0.47,"D",0.35,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G40-delE52!H40","v":0}]
[39,39,"N","L","H",4,0,0,0,0,4,6,0,2,"b","b","b","b",72,7,24,32,27,20,16,14,12,9,7,5,4,39,"N",0.13,"-",0.37,"-",0.47,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G41-delE52!H41","v":0}]
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[1922,1922,"H","L","H",6,0,36,0,20,1,7,0,1,"b","e","b","i",79,8,15,16,17,18,21,22,22,19,14,9,6,1922,"H",0.23,"-",0.46,"-",0.13,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1924-delE52!H1924","v":0}]
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[1929,1929,"T","L","H",4,0,0,0,0,3,6,0,2,"b","b","b","b",71,5,26,30,27,22,19,15,12,8,5,3,2,1929,"T",0.06,"-",0.34,"-",0.14,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1931-delE52!H1931","v":0}]
[1930,1930,"P","L","H",5,0,0,0,0,2,7,0,1,"b","b","b","b",79,6,20,25,23,19,17,16,15,14,11,8,6,1930,"P",0.08,"-",0.35,"-",0.14,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1932-delE52!H1932","v":0}]
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[1933,1933,"S","L","H",7,0,39,0,30,1,8,0,1,"b","e","b","i",85,5,12,17,16,16,19,21,23,21,16,11,8,1933,"S",0.09,"-",0.41,"-",0.13,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1935-delE52!H1935","v":0}]
[1935,1935,"L","L","H",6,0,0,0,0,9,7,0,1,"b","b","b","b",80,7,16,43,34,19,12,8,5,3,2,1,0,1935,"L",0.14,"-",0.34,"-",0.14,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1937-delE52!H1937","v":0}]
[1936,1936,"V","L","H",6,0,0,0,0,0,7,1,1,"b","b","b","b",77,13,17,22,21,20,20,20,18,16,14,11,9,1936,"V",0.14,"-",0.43,"-",0.17,"-",0.26,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1938-delE52!H1938","v":0}]
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[1939,1939,"C","L","L",2,0,0,0,0,1,3,1,5,"b","b","b","b",32,17,54,25,24,23,21,19,16,11,8,6,5,1939,"C",0.24,"-",0.58,"D",0.25,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1941-delE52!H1941","v":0}]
[1942,1942,"N","L","L",5,0,141,0,90,2,2,0,7,"b","e","b","e",21,6,73,6,6,8,10,13,16,20,23,27,29,1942,"N",0.25,"-",0.73,"D",0.67,"D",0.424,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1944-delE52!H1944","v":0}]
[1943,1943,"D","L","L",5,0,146,0,90,3,2,0,7,"b","e","b","e",24,4,74,4,5,6,9,12,16,20,24,28,30,1943,"D",0.21,"-",0.74,"D",0.86,"D",0.408,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1945-delE52!H1945","v":0}]
[1945,1945,"A","L","L",4,0,31,0,30,0,2,0,6,"b","e","b","i",23,9,68,10,11,13,16,19,21,21,21,20,18,1945,"A",0.23,"-",0.79,"D",0.78,"D",0.404,3,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1947-delE52!H1947","v":0}]
[1946,1946,"K","L","L",3,0,86,0,42,2,3,0,6,"b","e","b","e",31,5,65,9,10,11,14,18,21,23,21,17,14,1946,"K",0.26,"-",0.7,"D",0.78,"D",0.374,4,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1948-delE52!H1948","v":0}]
[1948,1948,"Q","L","H",4,0,110,0,56,2,7,0,2,"b","e","b","e",69,2,27,7,8,9,12,15,18,22,24,23,21,1948,"Q",0.21,"-",0.66,"D",0.37,"-",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1950-delE52!H1950","v":0}]
[1949,1949,"R","L","H",5,0,49,0,20,2,7,0,2,"b","e","b","i",75,3,23,13,14,16,20,23,23,21,16,10,6,1949,"R",0.22,"-",0.56,"D",0.38,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1951-delE52!H1951","v":0}]
[1951,1951,"T","L","H",8,0,17,0,12,0,9,0,0,"b","b","b","i",92,1,6,19,19,20,22,21,19,15,10,6,3,1951,"T",0.17,"-",0.41,"-",0.28,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1953-delE52!H1953","v":0}]
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[1956,1956,"K","L","H",8,0,0,0,0,0,9,0,0,"b","b","b","b",92,1,6,24,23,22,22,21,18,13,8,4,2,1956,"K",0.09,"-",0.3,"-",0.14,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1958-delE52!H1958","v":41}]
[1958,1958,"I","L","H",8,0,0,0,0,6,8,0,0,"b","b","b","b",90,4,9,37,31,20,14,10,7,4,2,1,0,1958,"I",0.1,"-",0.28,"-",0.21,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1960-delE52!H1960","v":0}]
[1959,1959,"T","L","H",6,0,0,0,0,0,7,0,1,"b","b","b","b",82,9,13,23,22,20,20,19,18,15,11,7,5,1959,"T",0.1,"-",0.35,"-",0.4,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1961-delE52!H1961","v":0}]
[1961,1961,"T","L","H",2,0,0,0,0,6,5,2,2,"b","b","b","b",54,26,25,36,30,20,16,14,11,7,5,3,2,1961,"T",0.1,"-",0.32,"-",0.21,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1963-delE52!H1963","v":0}]
[1962,1962,"I","L","H",1,0,0,0,0,4,4,2,2,"b","b","b","b",46,28,27,33,29,22,18,14,11,8,6,5,4,1962,"I",0.09,"-",0.5,"D",0.22,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1964-delE52!H1964","v":0}]
[1964,1964,"E","L","L",1,0,58,0,30,1,3,1,4,"b","e","b","i",38,13,50,10,11,13,16,20,22,22,20,17,15,1964,"E",0.12,"-",0.56,"D",0.35,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1966-delE52!H1966","v":0}]
[1965,1965,"K","L","L",1,0,86,0,42,0,3,0,5,"b","e","b","e",37,10,55,13,13,14,16,18,20,21,21,19,18,1965,"K",0.13,"-",0.6,"D",0.34,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1967-delE52!H1967","v":0}]
[1968,1968,"Y","L","L",3,0,26,0,12,0,2,0,6,"b","b","b","i",29,7,66,19,20,20,22,21,19,16,11,7,5,1968,"Y",0.12,"-",0.49,"D",0.62,"D",0.313,6,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1970-delE52!H1970","v":0}]
[1969,1969,"P","L","H",2,0,40,0,30,2,6,0,3,"b","e","b","i",63,4,36,13,13,14,17,19,21,20,18,13,10,1969,"P",0.13,"-",0.49,"D",0.39,"-",0.3,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1971-delE52!H1971","v":0}]
[1971,1971,"I","L","H",7,0,0,0,0,2,8,0,1,"b","b","b","b",87,3,10,28,25,22,20,17,14,10,6,4,2,1971,"I",0.14,"-",0.41,"-",0.19,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1973-delE52!H1973","v":0}]
[1972,1972,"Q","L","H",8,0,0,0,0,5,9,0,0,"b","b","b","b",91,2,6,34,29,19,17,13,10,6,4,2,1,1972,"Q",0.13,"-",0.38,"-",0.25,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1974-delE52!H1974","v":0}]
[1974,1974,"K","L","H",8,0,41,0,20,2,9,0,0,"b","e","b","i",91,2,6,16,17,20,25,26,25,18,11,5,2,1974,"K",0.25,"-",0.43,"-",0.21,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1976-delE52!H1976","v":0}]
[1975,1975,"I","L","H",8,0,0,0,0,9,9,0,0,"b","b","b","b",93,2,4,43,33,17,11,8,5,3,2,1,0,1975,"I",0.22,"-",0.34,"-",0.21,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1977-delE52!H1977","v":0}]
[1977,1977,"G","L","H",8,0,0,0,0,1,8,0,0,"b","b","b","b",90,3,8,22,21,19,18,18,17,15,13,9,6,1977,"G",0.13,"-",0.4,"-",0.19,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1979-delE52!H1979","v":0}]
[1978,1978,"S","L","H",7,0,26,0,20,1,8,0,1,"b","e","b","i",87,3,11,18,18,18,21,22,22,19,14,9,7,1978,"S",0.09,"-",0.43,"-",0.24,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1980-delE52!H1980","v":13}]
[1980,1980,"G","L","H",1,0,0,0,0,0,5,0,3,"b","b","b","b",59,3,40,24,23,22,22,20,18,15,12,10,9,1980,"G",0.08,"-",0.47,"D",0.14,"-",0.27,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1982-delE52!H1982","v":0}]
[1981,1981,"Q","L","L",1,0,110,0,56,3,4,0,5,"b","e","b","e",42,4,58,6,6,8,11,14,19,24,26,26,24,1981,"Q",0.07,"-",0.67,"D",0.2,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1983-delE52!H1983","v":0}]
[1984,1984,"D","L","L",3,0,91,0,56,3,3,0,6,"b","e","b","e",33,6,66,5,5,6,9,13,18,23,26,26,26,1984,"D",0.14,"-",0.59,"D",0.15,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1986-delE52!H1986","v":0}]
[1985,1985,"L","L","H",1,0,0,0,0,0,5,0,3,"b","b","b","b",56,9,37,23,23,22,21,20,18,15,11,8,7,1985,"L",0.14,"-",0.46,"-",0.16,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1987-delE52!H1987","v":0}]
[{"$f":"A1988+1","v":1987},1987,"D","L","H",5,0,48,0,30,1,7,0,2,"b","e","b","i",73,6,20,13,14,16,18,21,22,20,16,11,8,1987,"D",0.13,"-",0.42,"-",0.16,"-",0.242,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1989-delE52!H1989","v":0}]
[1988,1988,"V","L","H",7,0,0,0,0,1,8,0,1,"b","b","b","b",82,7,12,25,24,22,21,19,16,11,7,4,2,1988,"V",0.12,"-",0.3,"-",0.14,"-",0.25,9,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1990-delE52!H1990","v":0}]
[1990,1990,"L","L","H",8,0,0,0,0,7,9,0,0,"b","b","b","b",92,2,6,39,32,19,14,10,7,5,2,1,0,1990,"L",0.09,"-",0.32,"-",0.18,"-",0.253,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1992-delE52!H1992","v":0}]
[1991,1991,"D","L","H",8,0,32,0,20,2,9,0,0,"b","e","b","i",93,1,5,16,17,19,22,24,24,20,14,7,4,1991,"D",0.06,"-",0.37,"-",0.25,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1993-delE52!H1993","v":0}]
[1993,1993,"F","L","H",9,0,0,0,0,9,9,0,0,"b","b","b","b",95,1,3,45,35,17,10,6,4,2,1,0,0,1993,"F",0.1,"-",0.28,"-",0.26,"-",0.263,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1995-delE52!H1995","v":0}]
[1994,1994,"I","L","H",9,0,0,0,0,6,9,0,0,"b","b","b","b",95,2,3,38,32,20,15,11,7,4,2,1,0,1994,"I",0.11,"-",0.29,"-",0.31,"-",0.273,8,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1996-delE52!H1996","v":0}]
[1997,1997,"S","L","H",6,0,0,0,0,7,8,0,1,"b","b","b","b",84,3,15,40,32,20,14,11,8,5,3,2,1,1997,"S",0.15,"-",0.35,"-",0.22,"-",0.283,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G1999-delE52!H1999","v":0}]
[1998,1998,"A","L","H",4,0,0,0,0,1,7,0,2,"b","b","b","b",73,5,25,25,24,22,20,18,16,13,10,8,7,1998,"A",0.17,"-",0.47,"D",0.34,"-",0.293,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G2000-delE52!H2000","v":0}]
[2000,2000,"G","L","L",2,0,25,0,30,2,3,0,5,"b","e","b","i",39,5,59,9,10,14,19,22,24,23,20,17,14,2000,"G",0.15,"-",0.64,"D",0.33,"-",0.303,7,"-","-",{"$nulls":11},{"$f":"Nf1fl!G2002-delE52!H2002","v":0}]
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[2789,2748,"S","L","L",6,0,39,0,30,1,1,1,7,"b","e","b","i",12,13,78,15,15,16,18,20,21,20,18,17,17,2748,"S",0.65,"D",0.47,"D",0.52,"-",0.606,3,"D","P",{"$nulls":11},{"$f":"Nf1fl!G2791-delE52!H2791","v":54}]
[2790,2749,"G","L","L",6,0,25,0,30,1,1,1,7,"b","e","b","i",12,12,79,14,15,16,19,20,21,20,19,17,16,2749,"G",0.49,"-",0.41,"-",0.57,"-",0.592,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2792-delE52!H2792","v":0}]
[2791,2750,"R","L","L",5,0,49,0,20,1,1,1,6,"b","e","b","i",15,17,73,15,16,18,20,22,22,20,17,15,13,2750,"R",0.52,"D",0.54,"D",0.59,"D",0.616,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2793-delE52!H2793","v":0}]
[2792,2751,"T","L","L",5,0,28,0,20,0,1,1,6,"b","e","b","i",20,16,70,18,18,18,20,21,21,19,17,14,12,2751,"T",0.57,"D",0.49,"D",0.74,"D",0.616,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2794-delE52!H2794","v":0}]
[2793,2752,"R","L","L",4,0,29,0,12,0,1,1,6,"b","b","b","i",19,20,67,20,21,21,22,21,19,16,12,9,7,2752,"R",0.57,"D",0.42,"-",0.76,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2795-delE52!H2795","v":0}]
[2794,2753,"H","L","L",4,0,0,0,0,0,1,2,6,"b","b","b","b",17,21,67,23,23,22,21,20,18,15,12,10,8,2753,"H",0.6,"D",0.43,"-",0.66,"D",0.626,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2796-delE52!H2796","v":0}]
[2795,2754,"G","L","L",4,0,10,0,12,0,1,1,6,"b","b","b","i",21,19,67,20,20,20,22,21,20,18,15,13,11,2754,"G",0.57,"D",0.49,"D",0.73,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2797-delE52!H2797","v":0}]
[2796,2755,"S","L","L",4,0,0,0,0,0,2,1,6,"b","b","b","b",24,16,69,23,22,20,20,20,19,17,15,13,11,2755,"S",0.64,"D",0.47,"D",0.83,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2798-delE52!H2798","v":0}]
[2797,2756,"A","L","L",0,0,0,0,0,1,4,1,4,"b","b","b","b",48,12,51,25,24,21,21,19,18,15,14,13,12,2756,"A",0.7,"D",0.41,"-",0.87,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2799-delE52!H2799","v":0}]
[2798,2757,"S","L","L",0,0,39,0,30,0,4,1,4,"b","e","b","i",48,11,51,12,13,14,17,19,21,21,21,20,19,2757,"S",0.72,"D",0.57,"D",0.87,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2800-delE52!H2800","v":0}]
[2799,2758,"Q","L","L",0,0,83,0,42,1,4,1,4,"b","e","b","e",48,13,48,9,10,13,17,20,23,24,23,20,18,2758,"Q",0.72,"D",0.62,"D",0.9,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2801-delE52!H2801","v":0}]
[2800,2759,"V","L","L",1,0,17,0,12,0,3,1,4,"b","b","b","i",37,18,53,20,20,20,21,21,19,16,13,12,11,2759,"V",0.67,"D",0.61,"D",0.91,"D",0.636,4,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2802-delE52!H2802","v":11}]
[2801,2760,"Q","L","L",4,0,59,0,30,0,2,1,5,"b","e","b","i",24,21,65,12,13,14,17,20,22,22,21,19,17,2760,"Q",0.69,"D",0.69,"D",0.88,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2803-delE52!H2803","v":24}]
[2802,2761,"K","L","L",5,0,114,0,56,3,1,1,6,"b","e","b","e",18,17,73,6,7,9,12,16,20,24,26,26,25,2761,"K",0.69,"D",0.69,"D",0.9,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2804-delE52!H2804","v":33}]
[2803,2762,"Q","L","L",5,0,83,0,42,0,1,1,7,"b","e","b","e",15,16,75,8,8,11,15,18,21,23,23,23,22,2762,"Q",0.61,"D",0.6,"D",0.79,"D",0.643,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2805-delE52!H2805","v":27}]
[2804,2763,"R","L","L",5,0,74,0,30,0,1,1,7,"b","e","b","i",18,13,75,10,11,13,17,19,22,22,22,22,21,2763,"R",0.62,"D",0.66,"D",0.87,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2806-delE52!H2806","v":64}]
[2805,2764,"S","L","L",5,0,93,0,72,0,1,1,7,"b","e","b","e",19,12,74,10,10,12,15,18,20,21,21,23,23,2764,"S",0.62,"D",0.61,"D",0.93,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2807-delE52!H2807","v":-67}]
[2806,2765,"A","L","L",4,0,76,0,72,1,2,1,6,"b","e","b","e",24,15,68,10,10,12,15,17,19,21,22,23,23,2765,"A",0.6,"D",0.62,"D",0.92,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2808-delE52!H2808","v":-45}]
[2807,2766,"G","L","L",5,0,10,0,12,0,1,1,6,"b","b","b","i",19,16,69,20,20,20,21,21,20,18,16,15,14,2766,"G",0.56,"D",0.54,"D",0.85,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2809-delE52!H2809","v":15}]
[2808,2767,"S","L","L",4,0,39,0,30,0,2,1,6,"b","e","b","i",24,15,70,15,14,14,17,19,21,21,21,20,19,2767,"S",0.57,"D",0.54,"D",0.73,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2810-delE52!H2810","v":-39}]
[2809,2768,"F","L","L",2,0,0,0,0,0,2,2,5,"b","b","b","b",30,22,57,23,23,23,23,20,17,13,10,9,8,2768,"F",0.68,"D",0.63,"D",0.83,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2811-delE52!H2811","v":0}]
[2810,2769,"K","L","L",2,0,114,0,56,2,3,1,5,"b","e","b","e",32,18,56,6,7,8,12,16,20,23,24,23,21,2769,"K",0.59,"D",0.57,"D",0.91,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2812-delE52!H2812","v":-28}]
[2811,2770,"R","L","L",0,0,74,0,30,0,4,1,4,"b","e","b","i",45,16,47,8,10,13,18,21,23,23,22,20,18,2770,"R",0.68,"D",0.6,"D",0.86,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2813-delE52!H2813","v":0}]
[2812,2771,"N","L","H",0,0,87,0,56,1,4,1,4,"b","e","b","e",49,12,49,7,8,10,14,17,20,22,23,23,23,2771,"N",0.33,"-",0.71,"D",0.83,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2814-delE52!H2814","v":26}]
[2813,2772,"S","L","H",1,0,72,0,56,1,5,1,3,"b","e","b","e",57,16,41,10,11,13,16,18,20,22,23,22,21,2772,"S",0.22,"-",0.58,"D",0.8,"D",0.646,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2815-delE52!H2815","v":0}]
[2814,2773,"I","L","H",0,0,50,0,30,0,4,1,4,"b","e","b","i",52,17,46,13,14,15,17,19,20,20,20,19,18,2773,"I",0.42,"-",0.59,"D",0.91,"D",0.667,6,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2816-delE52!H2816","v":0}]
[2815,2774,"K","L","L",0,0,147,0,72,3,3,1,4,"b","e","b","e",42,20,51,3,3,6,9,14,18,23,27,28,28,2774,"K",0.34,"-",0.68,"D",0.81,"D",0.657,5,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2817-delE52!H2817","v":0}]
[2816,2775,"K","L","L",2,0,147,0,72,2,2,2,4,"b","e","b","e",30,27,56,4,4,7,10,14,18,23,26,27,27,2775,"K",0.39,"-",0.79,"D",0.77,"D",0.582,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2818-delE52!H2818","v":0}]
[2817,2776,"I","L","L",3,0,152,0,90,0,1,2,6,"b","e","b","e",17,25,63,9,10,12,15,17,18,18,18,19,20,2776,"I",0.36,"-",0.77,"D",0.77,"D",0.586,2,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2819-delE52!H2819","v":-132}]
[2818,2777,"V","L","L",8,0,127,0,90,4,0,0,8,"b","e","b","e",3,8,91,4,4,5,7,9,12,16,19,28,32,2777,"V",0.37,"-",0.84,"D",0.74,"D",0.541,0,"D","-",{"$nulls":11},{"$f":"Nf1fl!G2820-delE52!H2820","v":0}]
[{"$nulls":53},"SUM:",{"$f":"SUM(BC1:BC2820)","v":3307}]
[{"$nulls":54},{"$f":"SUM(BC2:BC2820)-SUM(BC2520:BC2560)","v":988}]
[{"$nulls":6},"Light red fill with dark red text: different to Nf1fl prediction.",{"$nulls":46},"Top value: A positive value means that the NF1 protein has a larger predicted total solvent accessibility in square Angstroem than the protein without the exon. Bottom value: A positive value means that the predicted total solvent accessibility in square Angstroem of NF1 minus the area contributed by the exon is larger than that of the protein with exon deletion."]
[{"$nulls":6},"Light yellow fill with dark yellow text: larger than Nf1fl prediction."]
[{"$nulls":6},"Light green fill with dark green text: smaller than Nf1fl prediction."]
[]
[{"$nulls":6},"CSRD"]
[{"$nulls":6},"GRD"]
[{"$nulls":6},"Sec14 & PH"]
[{"$nulls":6},"Tubulin & Syndecan BDs"]
[]
[]
[]
[]
[{"$nulls":4},41,null,null,"Number of residues in the deleted exon"]
[]
[{"$nulls":4},{"$f":"SUMPRODUCT(--(E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))-E2835","v":73},{"$nulls":10},{"$f":"SUMPRODUCT(--(P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820))-E2835","v":99},null,{"$f":"SUMPRODUCT(--(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))-E2835","v":201},null,null,"(Number of differences to the values in the corresponding columns in sheet Nf1fl)",{"$nulls":33},{"$f":"SUMPRODUCT(--(ABS(BC3:BC2820)>=50))","v":49},{"$nulls":5},"(This value shows the number of entries with absolute value >=50 (in Angstrom); this is an arbitrary cut-off.)"]
[{"$nulls":16},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820) + (R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))>0)*1))-E2835","v":240},{"$nulls":3},"(Number of difference in either one of the two columns P and R when compared to the corresponding columns in sheet Nf1fl)"]
[]
[{"$nulls":4},{"$f":"E2837/(2818-E2835)","v":{"v":0.02628736046092906,"d":"3%"}},{"$nulls":11},{"$f":"Q2838/(2818-E2835)","v":{"v":0.08642419877565719,"d":"9%"}},{"$nulls":3},"(Above number in terms of % of the total number of residues in the reduced protein)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=0))>0))-E2835","v":117},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 0)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=1))>0))","v":90},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 1)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=2))>0))","v":29},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 2)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=3))>0))","v":4},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 3)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=4))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 4)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=5))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 5)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=6))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 6)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=7))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 7)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=8))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 8)"]
[{"$nulls":10},{"$f":"SUMPRODUCT(--((((P3:P2820<>Nf1fl!O3:'Nf1fl'!O2820)+(R3:R2820<>Nf1fl!Q3:'Nf1fl'!Q2820))*(K3:K2820=9))>0))","v":0},{"$nulls":9},"(Number of residues that have a predicted accessibility according to either Pbie or Pbe and predicted accuracy of 9)"]
[]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=0))>0))-E2835","v":66},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 0)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=1))>0))","v":5},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 1)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=2))>0))","v":2},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 2)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=3))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 3)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=4))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 4)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=5))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 5)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=6))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 6)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=7))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 7)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=8))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 8)"]
[{"$nulls":5},{"$f":"SUMPRODUCT(--((((E3:E2820<>Nf1fl!D3:'Nf1fl'!D2820))*(F3:F2820=9))>0))","v":0},{"$nulls":14},"(Number of residues that have a predicted change in sec structure according to PHEL and predicted accuracy of 9)"]
[]
[{"$nulls":20},"(Changes from - to D and - to P , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AP3:AP2820,\"D\",Nf1fl!AO3:AO2820,\"-\")","v":3},{"$f":"COUNTIFS(AQ3:AQ2820,\"P\",Nf1fl!AP3:AP2820,\"-\")","v":6}]
[{"$nulls":20},"(Changes from D to - and P to - , respectively)",{"$nulls":20},{"$f":"COUNTIFS(AP3:AP2820,\"-\",Nf1fl!AO3:AO2820,\"D\")","v":18},{"$f":"COUNTIFS(AQ3:AQ2820,\"-\",Nf1fl!AP3:AP2820,\"P\")","v":14}]

{"sheet":"Exons - Overview","index":14,"n_rows":19,"n_cols":26,"rows_kept":19,"merged":[[0,5,0,11],[0,18,0,23],[2,5,2,7],[2,8,2,11],[2,18,2,23],[16,5,16,11],[16,18,16,23],[17,5,17,11],[17,18,17,23]]}
[{"$nulls":5},"Protein Predict (summary results)",{"$nulls":7},"Secondary structure (brief)","Non-ordinary secondary structure",null,"Protein Protein binding",null,"Prosite",{"$nulls":6},"Other PTM predictors"]
["Exon No.","Amino Acid Sequence","Start Position","End Position","Length","helix (PROFsec-PHEL; REPROFsec)","exposed (PROFAcc)","disordered (PROFbval; Ucon; NORSnet; MD)","helix (PROFsec-PHEL)","helix (REPROFsec)","exposed (PROFAcc)","disordered (PROFbval; Ucon; NORSnet; MD)",null,"From top to bottom, figures show: \nAA;\nSecondary Structure: \nOBS_sec (ignore this line, it is blank anyways), \nPROF_sec, \nRel_sec, \nSUB_sec; (subset of the PHDsec prediction, for all residues with an expected average accuracy > 82% (tables in header))\nSolvent Accessibility: \nO_3_acc (ignore this line, it is not a prediction, it always shows 'b's), \nP_3_acc,  \nRel_acc, \nSUB_acc; (e: residues exposed with more than 16% of their surface, b: rest <- this information may apply to the text version but seems incorrect for the graphical/html putput)","From top to bottom, figures show: SEQ (AA sequence; black), NORS (disordered; blue), SEC (secondary structure; red), COILS, HTM (trans-membrane), and ACC (solvent accessibility; green)",null,"PROFisis -  a machine learning-based method that identifies interacting residues from sequence alone. Although the method is developed using transient protein–protein interfaces from complexes of experimentally known 3D structures, it never explicitly uses 3D infor- mation. Instead, it combines predicted structural features with evolutionary information.",null,"Pattern-ID: ASN_GLYCOSYLATION \nPS00001 PDOC00001 \nPattern-DE: N-glycosylation site \nPattern: N[^P][ST][^P]","Pattern-ID: PKC_PHOSPHO_SITE \nPS00005 PDOC00005 \nPattern-DE: Protein kinase C phosphorylation site\nPattern: [ST].[RK]","Pattern-ID: CAMP_PHOSPHO_SITE PS00004 PDOC00004\nPattern-DE: cAMP- and cGMP-dependent protein kinase phosphorylation site\nPattern:    [RK]{2}.[ST]","Pattern-ID: CK2_PHOSPHO_SITE \nPS00006 PDOC00006 \nPattern-DE: Casein kinase II phosphorylation site \nPattern: [ST].{2}[DE]","Pattern-ID: TYR_PHOSPHO_SITE \nPS00007 PDOC00007\nPattern-DE: Tyrosine kinase phosphorylation site\nPattern: [RK].{2,3}[DE].{2,3}Y","Pattern-ID: MYRISTYL \nPS00008 PDOC00008, \nPattern-DE: N-myristoylation site, \nPattern: G[^EDRKHPFYW].{2}[STAGCN][^P]",null,"Other PTMs  (Prediction of Ubiq. Sites):\nCKSAAP_UbSite / UbiProber (score >0.8)"]
[{"$nulls":5},"%",null,null,"region",{"$nulls":4},"https://www.rostlab.org/owiki/index.php/PROFphd","https://www.ncbi.nlm.nih.gov/pubmed/12824431\nhttps://rostlab.org/owiki/index.php/NORSp_-_predictor_of_NOn-Regular_Secondary_Structure",null,"https://rostlab.org/owiki/index.php/PROFisis",null,"(marked in red are those also reported in Phosphosite and/or UniProtKB for NF1 isoform 1 or 2)"]
[9,"KLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLK",297,354,58,"76%;\n60%",{"v":0.33,"d":"33%"},"64%;\n0%;\n0%;\n0%; ","297-308, 317-333, 340-354 (44/58)","297-307, 316-330,  346-354 (35/58)","297, 300, 304, 307-314, 334-338, 346, 350, 354 (19/58)","297-298, 301, 304-316, 335-340, 350-354 (27/58); \n- (0/58); \n- (0/58); \n- (0/58);",{"$nulls":4},"None predicted for this region.",null,null,"residue: 302, pattern SLR",{"$nulls":5},"K-297 (low confidence)\nK-305 (high confidence)"]
[12,"SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAP",421,464,44,"59%;\n55%",{"v":0.59,"d":"59%"},"66%;\n0%;\n5%;\n2%; ","429-454 (26/44)","429-452 (24/44)","421, 423, 426, 429-430, 433, 436-437, 440, 443-444, 447-448, 451-452, 454-464 (26/44)","421-424, 426-431, 434, 437-438, 441, 449, 451-464 (29/44);\n- (0/44);\n463-464 (2/44);\n464 (1/44)",{"$nulls":4},"None predicted for this region.",{"$nulls":4},"residue 421,  pattern SALD",null,"residue 455, pattern GAHPAI"]
[17,"QADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEELLRTPGASLRKGKGNSSM",616,667,52,"81%; 73%",{"v":0.44,"d":"44%"},"44%;\n27%;\n0%;\n0%; ","622-642, 645-665 (42/52)","616-627, 632, 633, 634-635, 641-662 (38/52)","618, 635-645, 647, 651, 658-659, 661-667 (23/52) ","616-620, 638-648, 661-667 (23/52);\n616-617, 643, 656-666 (14/52);\n- (0/52);\n- (0/52);",{"$nulls":4},"Protein binding predicted at position 660 (K).",null,"residue 639, pattern NTSQ;\nresidue 664, pattern NSSM","residue 657, pattern SLR",null,"residue 665, pattern SSMD"]
["18+19","DSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTE",668,775,108,"64%; 61%",{"v":0.4,"d":"40%"},"45%;\n5%;\n0%;\n0%; ","678-695, 700-718, 728-733, 735-742, 752-766, 773-775 (69/108);","678-696, 700-718, 731, 733, 735-742, 752-764, 771-775 (66/108);","668-678, 680-681, 684, 697, 699-700, 703, 707, 714, 717, 720-721, 723-725, 727-729, 732-733, 735, 738, 742-745, 756, 760, 763, 766, 770, 774 (43/108);","668-682, 698, 700-701, 717-734, 736, 741-746, 766-771 (49/108);\n769-770, 773-775 (5/108);\n- (0/108);\n- (0/108);",{"$nulls":4},"None predicted for this region.",null,null,"residue 750, pattern TGR",null,"residue 685, pattern TKLE\nresidue 737, pattern TFME",null,"residue 772, pattern GNTEAW"]
[20,"AWEDTHAKWEQATKLILNYPKAKMEDGQ",776,803,28,"64%; 64%",{"v":0.54,"d":"54%"},"50%;\n61%;\n0%;\n29%; ","776-793 (18/28);","776-793 (18/28);","781, 785, 788, 791-792, 794-803 (15/28);","789-790, 792-803 (14/28); \n776-784, 796-802 (17/28); \n- (0/28); \n796-803 (8/28);",{"$nulls":4},"Protein binding predicted at position 797 (A).",{"$nulls":6},"residue 772, pattern GNTEAW (this residue is not in this exon but the recognition pattern is partially in it)",null,"K-789  (low confidence);  K-798 (0.897)"]
[21,"AAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQ",804,950,147,"44%, 47%",{"v":0.59,"d":"59%"},"67%;\n7%;\n14%;\n13%; ","831-847, 888-905, 913-922, 927-945 (64/147);","807-808, 831-848, 887-904, 911-922, 927-945 (69/147);","804-806, 808-831, 834, 848, 852-863, 865-875, 877-879, 881-888, 891-892, 895-896, 899, 906-907, 911, 914, 918, 922, 926-927, 934, 938, 941-942, 945-950 (86/147)","804-836, 854-890, 892, 904-910, 914-915, 918-920, 923, 925, 927, 938-940, 942-950 (98/147); \n804-805, 809-810, 830-831, 868-870, 886-887 (11/147);\n812, 816-823, 861-868, 870-872 (20/147); \n804-805, 807-815, 867-873, 884 (19/147)",{"$nulls":4},"Protein binding predicted at positions 814 (K), 815 (K), 816 (R), 819 (H), 820 (V), 872 (E), 873 (R), 874 (K)",null,"residue 839, pattern NMTG","residue 871, pattern SER","residue 815, pattern RRMS\nresidue 873, pattern RKGS","residue 829, pattern SDTD\nresidue 833, pattern SLQE",null,"residue 875, pattern GSMISV",null,"K-918  (low confidence)\nK-943 (high confidence)"]
[25,"DLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLK",1067,1105,39,"72%, 72%",{"v":0.38,"d":"38%"},"64%;\n18%;\n3%;\n0%; ","1067-1082, 1094-1105 (28/39);","1067-1081, 1093-1105 (28/39)","1077, 1080-1081,  1085, 1087-1093, 1095-1096, 1099-1100 (15/39) ","1067-1071, 1081-1098, 1100-1101 (25/39); \n1069, 1085-1086, 1088, 1091, 1093, 1095 (7/39); \n1090 (1/39); \n- (0/39); ",{"$nulls":4},"Protein binding predicted at position 1090 (G)."]
[28,"DELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFK",1237,1290,54,"85%; 83%",{"v":0.26,"d":"26%"},"35%;\n0%;\n0%;\n0%; ","1237-1267, 1273-1275, 1279-1290 (46/54);","1237-1267, 1271, 1273-1274, 1280-1290 (45/54);","1244, 1254, 1261-1262, 1265-1266, 1268-1272, 1274-1276 (14/54);","1237-1238, 1248-1252, 1262-1263, 1265-1273, 1290 (19/54);\n- (0/54);\n- (0/54);\n- (0/54);",{"$nulls":4},"None predicted for this region.",{"$nulls":4},"residue 1234, pattern SQWD (this residue is not in this exon but the recognition pattern is partially in it)\nresidue 1245, pattern TLFD ",null,"residue 1277, pattern GNSLAS"]
[36,"HQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARR",1555,1591,37,"22%; \n0%",{"v":0.27,"d":"27%"},"65%;\n24%;\n0%;\n0%; ","1555-1562 (8/37)","- (0/37)","1556, 1558-1559, 1564, 1567-1568, 1576-1579 (10/37), ","1555-1570, 1576-1582, 1591 (24/37); \n1556-1564 (9/37);\n- (0/37); \n- (0/37);",{"$nulls":4},"Protein binding predicted at positions 1559 (E), 1560(K), 1561 (E).",null,null,"residue 1577, pattern TSK",{"$nulls":3},"residue 1576, pattern GTSKAG",null,"K-1567  (low confidence)"]
[41,"ITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSK",1982,2028,47,"70%; 66%",{"v":0.32,"d":"32%"},"36%;\n0%;\n0%;\n0%; ","1985-1999, 2007-2019, 2024-2028 (33/47);","1986-1999, 2007-2018, 2024-2028 (31/47);","1982-1983, 1986, 1998, 2000-2005, 2007, 2020, 2022-2023, 2026 (15/47); ","1982-1985, 1998-2008, 2023-2024 (17/47);\n- (0/47);\n- (0/47);\n- (0/47); ",{"$nulls":4},"None predicted for this region.",null,null,"residue 2004, pattern SIK \nresidue 2026, pattern SSK",{"$nulls":3},"residue 2000, pattern GGLGSI"]
[46,"ALESCLKGPDTYNSQVLIEATVIALTKLQPLLNK",2253,2286,34,"65%; 65%",{"v":0.44,"d":"44%"},"50%;\n0%;\n0%;\n0%; ","2253-2256, 2266-2283 (22/34)","2253-2256, 2265-2282 (22/34)","2254-2255, 2257-2264, 281-2282, 2284-2286 (15/34)","2255-2266, 2282-2286 (17/34);\n- (0/34);\n- (0/34);\n- (0/34); ",{"$nulls":4},"None predicted for this region.",{"$nulls":8},"K-2279  (low confidence); K-2286 (0.8029)"]
[47,"DSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDK",2287,2333,47,"70%; 72%",{"v":0.3,"d":"30%"},"40%;\n0%;\n0%;\n0%; ","2291-2303, 2307-2326 (33/47);","2290-2303, 2307-2326 (34/47);","2288, 2304-2306, 2314, 2318, 2321,2325-2328, 2330-2333 (14/47);","2287-2290, 2305-2307, 2322-2333 (19/47);\n- (0/47);\n- (0/47);\n- (0/47); ",{"$nulls":4},"Protein binding predicted at position 2287 (D).",null,null,"residue 2326, pattern SLR",null,"residue 2334, pattern SPEE (this residue is not in this exon nor is the recognition pattern but it is right next to the potentially modified residue)"]
[52,"GTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEM",{"$f":"2518","v":2518},{"$f":"2558","v":2558},41,"0%;  \n0%",{"v":0.98,"d":"98%"},"100%;\n93%;\n56%;\n98%; "," - (0/41);"," - (0/41);","2518-2520, 2522-2558 (40/41);","2518-2558 (41/41);\n2518-2519, 2522-2551, 2553-2558 (38/41);\n2534, 2537-2558 (23/41);\n2518-2519, 2521-2558 (40/41); ",{"$nulls":4},"None predicted for this region.",null,null,"residue 2519, pattern TRK",null,"residue 2554, pattern TDYE","residue 2549, pattern RRVAETDY","residue 2518, pattern GTRKSF",null,"K-2521 (0.8273)"]
[{"$nulls":14},"Interestingly, exon 51 is the only exon NORSp predicts to be fully disordered. Meta-Disorder (MD) predictions confirm high disorder (40 out of 41 residues). Moreover, NORSp predicts the region to be largely exposed to solvents (~80 %). It is therefore conceivable that this region plays a role in NF1 function.  Accordig to NORSp, exons 12, 17, 18/19, 20, 28, 40, 46 have ~45%, ~44%,  ~41%, ~64%, ~33%, ~38%, ~40% of their residues accessible to solvents, respectively. However, other predictors of accessibility may be more reliable.",null,"A single protein binding site has been predicted for exons 17, 20, 25, and 46, each. Three binding sites have been predicted for exon 35. Eight binding sites have been predicted for exon 21.",null,"Most exons (except 20, 25 and 45) have residues for which PTMs have been predicted usng Prosite (and the ones shown here are only predictions for a few PTM types). Prosite is part of the ProteinPredict server. Exon 20 has no predicted PTM residue but deleting it could perhaps influence the recognition pattern of a PTM residue in a neighboring exon. Exons 9 and 46 are predicted to have one PTM site, exons 12, 28, and 35 have two predicted PTM residues, exon 40 has three, exons 17, 18/19, and 51 have 4, and exon 21 has seven predicted PTM sites. Exons 17 and 51 each have a known phosphorylation site as reported in Phosphosite and/or UniProtKB. "]
[{"$nulls":5},"Note: PROFsec is an old method and was \"retired\" end of 2014. RePRO is the newer predictor.\nIntrinsically disordered proteins are predicted by Meta-Disorder (MD) from protein sequences. The prediction is based on a system of neural networks that combines the outputs from several original prediction methods (NORSnet, DISOPRED2,PROFbval and Ucon), with the evolutionary profiles and sequence features that correlate with the protein disorder such as predicted solvent accessibility and protein flexibility. The method was developed in 2005 by Avner Schlessinger & Burkhard Rost (Schlessinger & al. 2005).",{"$nulls":8},"NORSp is a on-line predictor of NOn-Regular Secondary Structure (NORS), i.e. disordered regions in a protein, these are structurally flexible regions that often play important roles in biological processes. Specifically, it predicts long regions with no regular secondary structure. Upon user submission of protein sequence, NORSp will analyse the protein about its secondary structure, and presence of transmembrane helices and coiled-coil. ",null,"Protein binding sites intuitively indicate functional importance. Deleting an exon with a protein binding site suggests loss of function.  ",null,"Posttranslational modifications are major effectors of protein structure and function and important mechanisms in signal transduction, activation and deactivation, etc. Consequently, potential PTM sites in exon regions are also indicators for functional relevance. "]
["Data obtained from ProteinPredict "]

{"sheet":"Consurf","index":15,"n_rows":2825,"n_cols":15,"rows_kept":2825}
[]
[" POS"," SEQ","SCORE",null,"COLOR","CONFIDENCE INTERVAL","CONFIDENCE INTERVAL COLORS","B/E","FUNCTION","MSA DATA","RESIDUE VARIETY"]
["    ","    ","(normalized)","        ","               "]
[1,"   M",-0.62,null,9,"-0.620,-0.620",null,null,"    9,9",null,null,"  e","       f"," 125/150","M,F,V"]
[2,"   A",-0.233,null,7,"-0.233,-0.233",null,null,"    7,7",null,null,"  e","        "," 125/150","P,G,L,T,A"]
[3,"   A",-0.361,null,7,"-0.361,-0.361",null,null,"    7,7",null,null,"  e","        "," 123/150","D,N,A,S,T,I,M"]
[4,"   H",-0.383,null,8,"-0.383,-0.383",null,null,"    8,8",null,null,"  e","       f"," 124/150","N,K,S,P,Q,R,H"]
[5,"   R",-0.537,null,9,"-0.537,-0.537",null,null,"    9,9",null,null,"  e","       f"," 126/150","K,R"]
[6,"   P",-0.46,null,8,"-0.460,-0.460",null,null,"    8,8",null,null,"  e","       f"," 126/150","P,F,S"]
[7,"   V",0.511,null,2," 0.511, 0.511",null,null,"    2,2",null,null,"  e","        "," 126/150","A,N,T,G,E,D,V,S"]
[8,"   E",-0.495,null,8,"-0.495,-0.495",null,null,"    8,8",null,null,"  e","       f"," 126/150","M,G,L,E"]
[9,"   W",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 126/150","W"]
[10,"   V",-0.608,null,9,"-0.608,-0.608",null,null,"    9,9",null,null,"  b","       s"," 126/150","A,V"]
[11,"   Q",0.195,null,4," 0.195, 0.195",null,null,"    4,4",null,null,"  e","        "," 126/150","N,A,T,R,Q,D,V,S,H"]
[12,"   A",0.411,null,2," 0.411, 0.411",null,null,"    2,2",null,null,"  b","        "," 126/150","A,T,W,G,Q,V,S,H,L"]
[13,"   V",-0.323,null,7,"-0.323,-0.323",null,null,"    7,7",null,null,"  b","        "," 126/150","V,I,L"]
[14,"   V",-0.143,null,6,"-0.143,-0.143",null,null,"    6,6",null,null,"  b","        "," 126/150","M,L,I,V"]
[15,"   S",1.511,null,1," 1.511, 1.511",null,null,"    1,1",null,null,"  b","        "," 126/150","C,S,V,I,M,K,A,N,T,R,G,Q"]
[16,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 126/150","R"]
[17,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 126/150","F"]
[18,"   D",-0.482,null,8,"-0.482,-0.482",null,null,"    8,8",null,null,"  e","       f"," 126/150","E,G,R,D"]
[19,"   E",0.215,null,4," 0.215, 0.215",null,null,"    4,4",null,null,"  e","        "," 127/150","A,S,D,E,L"]
[20,"   Q",-0.493,null,8,"-0.493,-0.493",null,null,"    8,8",null,null,"  e","       f"," 133/150","Q,R,D,N,K"]
[21,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 136/150","L"]
[22,"   P",-0.572,null,9,"-0.572,-0.572",null,null,"    9,9",null,null,"  e","       f"," 136/150","L,P"]
[23,"   I",0.003,null,5," 0.003, 0.003",null,null,"    5,5",null,null,"  e","        "," 136/150","S,V,N,C,Y,I"]
[24,"   K",0.068,null,5," 0.068, 0.068",null,null,"    5,5",null,null,"  e","        "," 136/150","C,K,H,E,R,G"]
[25,"   T",0.332,null,3," 0.332, 0.332",null,null,"    3,3",null,null,"  e","        "," 133/150","G,N,A,K,T,I,S,V,F,C"]
[26,"   G",-0.12,null,6,"-0.120,-0.120",null,null,"    6,6",null,null,"  e","        "," 135/150","S,C,D,G"]
[27,"   Q",1.707,null,1," 1.707, 1.707",null,null,"    1,1",null,null,"  e","        "," 135/150","A,N,T,Q,C,S,V,I,H,L,P"]
[28,"   Q",-0.163,null,6,"-0.163,-0.163",null,null,"    6,6",null,null,"  e","        "," 135/150","Y,R,E,Q,T,H,D,S"]
[29,"   N",0.366,null,3," 0.366, 0.366",null,null,"    3,3",null,null,"  e","        "," 135/150","P,G,T,N,S"]
[30,"   T",0.106,null,4," 0.106, 0.106",null,null,"    4,4",null,null,"  e","        "," 136/150","S,C,P,L,H,T,N,A,Q,G"]
[31,"   H",-0.047,null,5,"-0.047,-0.047",null,null,"    5,5",null,null,"  e","        "," 136/150","L,P,H,N,K,T,R,Q,Y"]
[32,"   T",-0.145,null,6,"-0.145,-0.145",null,null,"    6,6",null,null,"  e","        "," 136/150","G,P,N,S,A,T"]
[33,"   K",0.443,null,2," 0.443, 0.443",null,null,"    2,2",null,null,"  e","        "," 136/150","S,L,M,H,I,T,K,Q,R"]
[34,"   V",0.92,null,1," 0.920, 0.920",null,null,"    1,1",null,null,"  e","        "," 136/150","F,V,I,M,L,A,Y,Q,E"]
[35,"   S",-0.48,null,8,"-0.480,-0.480",null,null,"    8,8",null,null,"  e","       f"," 136/150","M,H,N,S"]
[36,"   T",0.092,null,4," 0.092, 0.092",null,null,"    4,4",null,null,"  e","        "," 136/150","L,M,I,V,D,Q,E,G,T"]
[37,"   E",-0.348,null,7,"-0.348,-0.348",null,null,"    7,7",null,null,"  e","        "," 136/150","K,D,E,Q,M"]
[38,"   H",-0.187,null,6,"-0.187,-0.187",null,null,"    6,6",null,null,"  e","        "," 136/150","K,N,R,M,Q,E,H"]
[39,"   N",-0.187,null,6,"-0.187,-0.187",null,null,"    6,6",null,null,"  e","        "," 136/150","C,S,N,T,I,L"]
[40,"   K",-0.052,null,5,"-0.052,-0.052",null,null,"    5,5",null,null,"  e","        "," 137/150","I,M,V,S,R,E,Q,K,T"]
[41,"   E",0.748,null,1," 0.748, 0.748",null,null,"    1,1",null,null,"  e","        "," 137/150","L,D,Q,E,G,R,T,A,K,N"]
[42,"   C",-0.409,null,8,"-0.409,-0.409",null,null,"    8,8",null,null,"  b","        "," 137/150","C,F,S,T,Y"]
[43,"   L",-0.565,null,9,"-0.565,-0.565",null,null,"    9,9",null,null,"  b","       s"," 136/150","I,L,V"]
[44,"   I",-0.548,null,9,"-0.548,-0.548",null,null,"    9,9",null,null,"  b","       s"," 136/150","I,V"]
[45,"   N",0.34,null,3," 0.340, 0.340",null,null,"    3,3",null,null,"  e","        "," 136/150","T,A,K,N,Q,E,R,Y,S,D,L,H"]
[46,"   I",-0.542,null,9,"-0.542,-0.542",null,null,"    9,9",null,null,"  b","       s"," 136/150","I,L,V"]
[47,"   S",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 136/150","S"]
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[140,"   G",-0.13,null,6,"-0.130,-0.130",null,null,"    6,6",null,null,"  e","        "," 137/150","K,A,G,R,Q,E"]
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[143,"   F",-0.277,null,7,"-0.277,-0.277",null,null,"    7,7",null,null,"  b","        "," 137/150","F,K,S,Y"]
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[146,"   S",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 137/150","S"]
[147,"   C",0.865,null,1," 0.865, 0.865",null,null,"    1,1",null,null,"  b","        "," 137/150","V,S,C,M,L,I,T,Q"]
[148,"   N",-0.521,null,8,"-0.521,-0.521",null,null,"    8,8",null,null,"  e","       f"," 137/150","N,S,T,H,Q"]
[149,"   N",-0.441,null,8,"-0.441,-0.441",null,null,"    8,8",null,null,"  b","        "," 137/150","F,N,Y,H"]
[150,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 137/150","F"]
[151,"   N",-0.233,null,7,"-0.233,-0.233",null,null,"    7,7",null,null,"  e","        "," 137/150","N,S,T,G"]
[152,"   A",-0.49,null,8,"-0.490,-0.490",null,null,"    8,8",null,null,"  b","        "," 137/150","I,T,A,V"]
[153,"   V",-0.649,null,9,"-0.649,-0.649",null,null,"    9,9",null,null,"  b","       s"," 136/150","L,V"]
[154,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 136/150","F"]
[155,"   S",-0.323,null,7,"-0.323,-0.323",null,null,"    7,7",null,null,"  b","        "," 136/150","H,T,S,N"]
[156,"   R",-0.524,null,8,"-0.524,-0.524",null,null,"    8,8",null,null,"  e","       f"," 136/150","R,K"]
[157,"   I",-0.653,null,9,"-0.653,-0.653",null,null,"    9,9",null,null,"  b","       s"," 136/150","I,V"]
[158,"   S",-0.389,null,8,"-0.389,-0.389",null,null,"    8,8",null,null,"  b","        "," 136/150","Q,P,L,T,S,A"]
[159,"   T",0.121,null,4," 0.121, 0.121",null,null,"    4,4",null,null,"  e","        "," 136/150","T,S,N,A,D,G,I"]
[160,"   R",-0.171,null,6,"-0.171,-0.171",null,null,"    6,6",null,null,"  e","        "," 136/150","C,K,S,H,R,L"]
[161,"   L",-0.568,null,9,"-0.568,-0.568",null,null,"    9,9",null,null,"  b","       s"," 136/150","L,I,T"]
[162,"   Q",-0.256,null,7,"-0.256,-0.256",null,null,"    7,7",null,null,"  e","        "," 134/150","A,T,E,Q,S,V,M,H"]
[163,"   E",-0.281,null,7,"-0.281,-0.281",null,null,"    7,7",null,null,"  e","        "," 137/150","N,V,A,T,L,E"]
[164,"   L",-0.489,null,8,"-0.489,-0.489",null,null,"    8,8",null,null,"  b","        "," 136/150","C,A,I,L"]
[165,"   T",0.018,null,5," 0.018, 0.018",null,null,"    5,5",null,null,"  e","        "," 136/150","Q,P,I,T,S,V,A"]
[166,"   V",0.977,null,1," 0.977, 0.977",null,null,"    1,1",null,null,"  e","        "," 136/150","G,Q,N,K,A,T,I,L,P,C,V,S"]
[167,"   C",0.502,null,2," 0.502, 0.502",null,null,"    2,2",null,null,"  e","        "," 136/150","P,S,V,A,T,C,D"]
[168,"   S",0.624,null,1," 0.624, 0.624",null,null,"    1,1",null,null,"  e","        "," 132/150","P,I,V,S,D,E,G,T,N,A"]
[169,"   E",0.268,null,3," 0.268, 0.268",null,null,"    3,3",null,null,"  e","        "," 136/150","L,Q,E,D,V"]
[170,"   D",-0.493,null,8,"-0.493,-0.493",null,null,"    8,8",null,null,"  e","       f"," 136/150","E,S,D"]
[171,"   N",0.049,null,5," 0.049, 0.049",null,null,"    5,5",null,null,"  e","        "," 136/150","I,Q,D,T,S,N"]
[172,"   V",0.662,null,1," 0.662, 0.662",null,null,"    1,1",null,null,"  e","        "," 136/150","V,A,S,T,M,P,Q"]
[173,"   D",-0.519,null,8,"-0.519,-0.519",null,null,"    8,8",null,null,"  e","       f"," 136/150","E,D"]
[174,"   V",1.402,null,1," 1.402, 1.402",null,null,"    1,1",null,null,"  b","        "," 136/150","T,Y,Q,C,F,V,I,H,L"]
[175,"   H",0.02,null,5," 0.020, 0.020",null,null,"    5,5",null,null,"  b","        "," 136/150","C,S,I,H,A,N,T,G"]
[176,"   D",-0.515,null,8,"-0.515,-0.515",null,null,"    8,8",null,null,"  e","       f"," 136/150","D,E"]
[177,"   I",-0.481,null,8,"-0.481,-0.481",null,null,"    8,8",null,null,"  b","        "," 136/150","L,I"]
[178,"   E",-0.573,null,9,"-0.573,-0.573",null,null,"    9,9",null,null,"  e","       f"," 136/150","D,E"]
[179,"   L",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 136/150","L,I"]
[180,"   L",-0.512,null,8,"-0.512,-0.512",null,null,"    8,8",null,null,"  b","        "," 136/150","I,M,L,V"]
[181,"   Q",-0.569,null,9,"-0.569,-0.569",null,null,"    9,9",null,null,"  e","       f"," 136/150","H,Q,R"]
[182,"   Y",-0.442,null,8,"-0.442,-0.442",null,null,"    8,8",null,null,"  b","        "," 136/150","H,Y"]
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[184,"   N",-0.436,null,8,"-0.436,-0.436",null,null,"    8,8",null,null,"  e","       f"," 136/150","H,D,S,N"]
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[220,"   F",-0.496,null,8,"-0.496,-0.496",null,null,"    8,8",null,null,"  b","        "," 138/150","V,C,F,L,I"]
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[281,"   I",-0.513,null,8,"-0.513,-0.513",null,null,"    8,8",null,null,"  b","        "," 137/150","L,I,T"]
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[290,"   D",-0.183,null,6,"-0.183,-0.183",null,null,"    6,6",null,null,"  e","        "," 137/150","R,G,E,I,S,A,D"]
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[295,"   N",-0.105,null,6,"-0.105,-0.105",null,null,"    6,6",null,null,"  e","        "," 138/150","S,N,K,R,Q"]
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[298,"   L",1.051,null,1," 1.051, 1.051",null,null,"    1,1",null,null,"  e","        "," 138/150","Q,T,N,A,L,M,H,I,S,D,C"]
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[300,"   L",-0.223,null,6,"-0.223,-0.223",null,null,"    6,6",null,null,"  b","        "," 138/150","V,F,L,M,I"]
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[306,"   A",-0.123,null,6,"-0.123,-0.123",null,null,"    6,6",null,null,"  b","        "," 138/150","G,S,N,A,C"]
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[309,"   G",1.097,null,1," 1.097, 1.097",null,null,"    1,1",null,null,"  e","        "," 133/150","I,M,L,P,S,V,G,Q,A,N,T"]
[310,"   H",-0.254,null,7,"-0.254,-0.254",null,null,"    7,7",null,null,"  e","        "," 137/150","Q,P,Y,H,S,N"]
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[313,"   S",-0.214,null,6,"-0.214,-0.214",null,null,"    6,6",null,null,"  e","        "," 138/150","Y,H,A,N,S,T"]
[314,"   R",-0.327,null,7,"-0.327,-0.327",null,null,"    7,7",null,null,"  e","        "," 138/150","K,R"]
[315,"   Q",-0.071,null,5,"-0.071,-0.071",null,null,"    5,5",null,null,"  e","        "," 138/150","Q,A,N,H,L,P,S,V"]
[316,"   L",0.103,null,4," 0.103, 0.103",null,null,"    4,4",null,null,"  b","        "," 138/150","I,M,L,Q,N,V,S"]
[317,"   T",0.165,null,4," 0.165, 0.165",null,null,"    4,4",null,null,"  b","        "," 139/150","T,A,Q,V,S,I,L,M"]
[318,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 139/150","E"]
[319,"   S",-0.296,null,7,"-0.296,-0.296",null,null,"    7,7",null,null,"  b","        "," 139/150","Y,G,T,V,A,S"]
[320,"   A",-0.555,null,9,"-0.555,-0.555",null,null,"    9,9",null,null,"  b","       s"," 139/150","S,A,G"]
[321,"   A",-0.182,null,6,"-0.182,-0.182",null,null,"    6,6",null,null,"  b","        "," 139/150","L,I,A,V,T"]
[322,"   I",-0.073,null,5,"-0.073,-0.073",null,null,"    5,5",null,null,"  b","        "," 139/150","L,I,V,T"]
[323,"   A",-0.283,null,7,"-0.283,-0.283",null,null,"    7,7",null,null,"  b","        "," 139/150","V,S,A,T"]
[324,"   C",-0.04,null,5,"-0.040,-0.040",null,null,"    5,5",null,null,"  b","        "," 139/150","F,C,S,A,T,G"]
[325,"   V",-0.528,null,8,"-0.528,-0.528",null,null,"    8,8",null,null,"  b","        "," 139/150","S,V,I"]
[326,"   K",-0.492,null,8,"-0.492,-0.492",null,null,"    8,8",null,null,"  e","       f"," 139/150","R,N,K"]
[327,"   L",-0.508,null,8,"-0.508,-0.508",null,null,"    8,8",null,null,"  b","        "," 139/150","F,L,M"]
[328,"   C",-0.304,null,7,"-0.304,-0.304",null,null,"    7,7",null,null,"  b","        "," 139/150","F,C,T,S,I"]
[329,"   K",-0.638,null,9,"-0.638,-0.638",null,null,"    9,9",null,null,"  e","       f"," 139/150","R,K"]
[330,"   A",-0.398,null,8,"-0.398,-0.398",null,null,"    8,8",null,null,"  b","        "," 139/150","I,V,S,A,T"]
[331,"   S",-0.436,null,8,"-0.436,-0.436",null,null,"    8,8",null,null,"  b","        "," 139/150","S,A,C"]
[332,"   T",-0.647,null,9,"-0.647,-0.647",null,null,"    9,9",null,null,"  e","       f"," 139/150","C,T"]
[333,"   Y",-0.62,null,9,"-0.620,-0.620",null,null,"    9,9",null,null,"  b","       s"," 139/150","Y,F"]
[334,"   I",-0.136,null,6,"-0.136,-0.136",null,null,"    6,6",null,null,"  b","        "," 139/150","L,M,I,T,V"]
[335,"   N",0.042,null,5," 0.042, 0.042",null,null,"    5,5",null,null,"  e","        "," 139/150","K,N,S,H"]
[336,"   W",0.295,null,3," 0.295, 0.295",null,null,"    3,3",null,null,"  b","        "," 139/150","D,F,S,V,I,P,T,N,W"]
[337,"   E",0.822,null,1," 0.822, 0.822",null,null,"    1,1",null,null,"  e","        "," 132/150","S,V,F,L,I,K,A,N,T,R,Q,E"]
[338,"   D",-0.23,null,7,"-0.230,-0.230",null,null,"    7,7",null,null,"  e","        "," 139/150","K,N,D,E,Q,H"]
[339,"   N",-0.171,null,6,"-0.171,-0.171",null,null,"    6,6",null,null,"  e","        "," 139/150","H,F,C,S,V,G,R,T,A,N"]
[340,"   S",-0.433,null,8,"-0.433,-0.433",null,null,"    8,8",null,null,"  e","       f"," 139/150","N,S,H,R"]
[341,"   V",-0.195,null,6,"-0.195,-0.195",null,null,"    6,6",null,null,"  b","        "," 139/150","T,N,A,G,F,V,I,P"]
[342,"   I",0.496,null,2," 0.496, 0.496",null,null,"    2,2",null,null,"  b","        "," 139/150","T,A,V,M,L,I"]
[343,"   F",-0.504,null,8,"-0.504,-0.504",null,null,"    8,8",null,null,"  b","        "," 139/150","I,L,F,C"]
[344,"   L",1.271,null,1," 1.271, 1.271",null,null,"    1,1",null,null,"  b","        "," 139/150","Q,A,K,T,I,H,M,L,F,V,S"]
[345,"   L",-0.444,null,8,"-0.444,-0.444",null,null,"    8,8",null,null,"  b","        "," 139/150","F,L,I"]
[346,"   V",-0.541,null,9,"-0.541,-0.541",null,null,"    9,9",null,null,"  b","       s"," 139/150","V,A"]
[347,"   Q",-0.172,null,6,"-0.172,-0.172",null,null,"    6,6",null,null,"  e","        "," 139/150","H,R,Q,N,V,K"]
[348,"   S",-0.135,null,6,"-0.135,-0.135",null,null,"    6,6",null,null,"  e","        "," 139/150","C,F,S,H,P,T,N,Y,Q,R"]
[349,"   M",0.102,null,4," 0.102, 0.102",null,null,"    4,4",null,null,"  b","        "," 139/150","M,L,I,V,F,C"]
[350,"   V",0.013,null,5," 0.013, 0.013",null,null,"    5,5",null,null,"  b","        "," 139/150","V,F,M,L,I,T,Q,Y"]
[351,"   V",0.472,null,2," 0.472, 0.472",null,null,"    2,2",null,null,"  e","        "," 139/150","Q,G,T,K,A,N,M,H,I,V,S,D"]
[352,"   D",-0.52,null,8,"-0.520,-0.520",null,null,"    8,8",null,null,"  e","       f"," 139/150","N,D,E"]
[353,"   L",-0.566,null,9,"-0.566,-0.566",null,null,"    9,9",null,null,"  b","       s"," 139/150","V,I,L"]
[354,"   K",-0.367,null,7,"-0.367,-0.367",null,null,"    7,7",null,null,"  e","        "," 139/150","K,T,M,Q,I"]
[355,"   N",1.646,null,1," 1.646, 1.646",null,null,"    1,1",null,null,"  e","        "," 139/150","L,M,I,V,S,C,G,T,A,N"]
[356,"   L",-0.377,null,7,"-0.377,-0.377",null,null,"    7,7",null,null,"  b","        "," 140/150","T,Q,M,L,I"]
[357,"   L",-0.566,null,9,"-0.566,-0.566",null,null,"    9,9",null,null,"  b","       s"," 140/150","V,I,L"]
[358,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 140/150","F"]
[359,"   N",-0.342,null,7,"-0.342,-0.342",null,null,"    7,7",null,null,"  e","        "," 140/150","T,K,N,S,L,H"]
[360,"   P",0.163,null,4," 0.163, 0.163",null,null,"    4,4",null,null,"  e","        "," 138/150","T,V,Q,P"]
[361,"   S",1.184,null,1," 1.184, 1.184",null,null,"    1,1",null,null,"  e","        "," 140/150","G,Q,E,A,N,T,L,I,S,V,C,D"]
[362,"   K",-0.589,null,9,"-0.589,-0.589",null,null,"    9,9",null,null,"  e","       f"," 140/150","T,K,N"]
[363,"   P",0.736,null,1," 0.736, 0.736",null,null,"    1,1",null,null,"  e","        "," 139/150","K,V,S,T,L,Q,P"]
[364,"   F",-0.157,null,6,"-0.157,-0.157",null,null,"    6,6",null,null,"  e","        "," 139/150","V,S,F,G,Y"]
[365,"   S",-0.012,null,5,"-0.012,-0.012",null,null,"    5,5",null,null,"  e","        "," 140/150","L,I,V,S,C,F,W,T,N,A"]
[366,"   R",-0.51,null,8,"-0.510,-0.510",null,null,"    8,8",null,null,"  e","       f"," 140/150","R,V,K"]
[367,"   G",0.073,null,5," 0.073, 0.073",null,null,"    5,5",null,null,"  e","        "," 139/150","T,S,N,V,G"]
[368,"   S",2.041,null,1," 2.041, 2.041",null,null,"    1,1",null,null,"  e","        "," 138/150","H,I,L,C,F,V,S,W,Y,G,T,N,A"]
[369,"   Q",1.048,null,1," 1.048, 1.048",null,null,"    1,1",null,null,"  e","        "," 138/150","Q,N,A,T,L,M,P,I,V,S"]
[370,"   P",1.656,null,1," 1.656, 1.656",null,null,"    1,1",null,null,"  e","        "," 140/150","F,V,S,I,L,P,K,A,N,T,Y,W,G,Q"]
[371,"   A",2E-3,null,5," 0.002, 0.002",null,null,"    5,5",null,null,"  e","        "," 140/150","H,L,D,S,Q,E,N,A,T"]
[372,"   D",-0.314,null,7,"-0.314,-0.314",null,null,"    7,7",null,null,"  e","        "," 140/150","E,D,T,S"]
[373,"   V",0.212,null,4," 0.212, 0.212",null,null,"    4,4",null,null,"  b","        "," 140/150","T,Y,E,V,S,I,M,L"]
[374,"   D",0.165,null,4," 0.165, 0.165",null,null,"    4,4",null,null,"  e","        "," 140/150","H,E,D,S"]
[375,"   L",-0.56,null,9,"-0.560,-0.560",null,null,"    9,9",null,null,"  b","       s"," 140/150","G,L,M"]
[376,"   M",-0.549,null,9,"-0.549,-0.549",null,null,"    9,9",null,null,"  b","       s"," 140/150","Y,I,M,L"]
[377,"   I",-0.437,null,8,"-0.437,-0.437",null,null,"    8,8",null,null,"  b","        "," 140/150","S,V,T,I,M"]
[378,"   D",-0.398,null,8,"-0.398,-0.398",null,null,"    8,8",null,null,"  e","       f"," 140/150","E,H,D"]
[379,"   C",-0.189,null,6,"-0.189,-0.189",null,null,"    6,6",null,null,"  b","        "," 140/150","S,C,F,G,Y"]
[380,"   L",-0.314,null,7,"-0.314,-0.314",null,null,"    7,7",null,null,"  b","        "," 140/150","F,W,Y,L"]
[381,"   V",-0.384,null,8,"-0.384,-0.384",null,null,"    8,8",null,null,"  b","        "," 140/150","I,L,V"]
[382,"   S",-0.585,null,9,"-0.585,-0.585",null,null,"    9,9",null,null,"  b","       s"," 140/150","A,S,T"]
[383,"   C",0.258,null,3," 0.258, 0.258",null,null,"    3,3",null,null,"  b","        "," 140/150","N,Y,S,V,C,F,L,I"]
[384,"   F",-0.57,null,9,"-0.570,-0.570",null,null,"    9,9",null,null,"  b","       s"," 140/150","Y,F"]
[385,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 140/150","R"]
[386,"   I",-0.483,null,8,"-0.483,-0.483",null,null,"    8,8",null,null,"  b","        "," 140/150","L,I,V"]
[387,"   S",0.234,null,3," 0.234, 0.234",null,null,"    3,3",null,null,"  e","        "," 140/150","N,K,T,Y,S,D,M,H"]
[388,"   P",-0.572,null,9,"-0.572,-0.572",null,null,"    9,9",null,null,"  e","       f"," 140/150","P,H"]
[389,"   H",0.127,null,4," 0.127, 0.127",null,null,"    4,4",null,null,"  e","        "," 140/150","K,N,Y,R,G,Q,V,S,I,H,L"]
[390,"   N",-0.443,null,8,"-0.443,-0.443",null,null,"    8,8",null,null,"  e","       f"," 140/150","I,N,K,S,D"]
[391,"   N",-0.4,null,8,"-0.400,-0.400",null,null,"    8,8",null,null,"  e","       f"," 140/150","I,G,D,K,S,N"]
[392,"   Q",0.032,null,5," 0.032, 0.032",null,null,"    5,5",null,null,"  e","        "," 140/150","P,E,Q,D,N,K"]
[393,"   H",0.427,null,2," 0.427, 0.427",null,null,"    2,2",null,null,"  b","        "," 140/150","C,V,I,H,L,M,P,A,T,Y,Q"]
[394,"   F",-0.14,null,6,"-0.140,-0.140",null,null,"    6,6",null,null,"  b","        "," 138/150","P,L,T,F"]
[395,"   K",-0.513,null,8,"-0.513,-0.513",null,null,"    8,8",null,null,"  e","       f"," 138/150","R,L,D,K"]
[396,"   I",-0.127,null,6,"-0.127,-0.127",null,null,"    6,6",null,null,"  b","        "," 139/150","L,I,T,V,A,F"]
[397,"   C",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 139/150","C"]
[398,"   L",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 141/150","L,S"]
[399,"   A",-0.175,null,6,"-0.175,-0.175",null,null,"    6,6",null,null,"  e","        "," 141/150","H,Q,S,A,N,T"]
[400,"   Q",1.014,null,1," 1.014, 1.014",null,null,"    1,1",null,null,"  e","        "," 141/150","G,Q,T,I,L,P,F,V,S"]
[401,"   N",0.619,null,1," 0.619, 0.619",null,null,"    1,1",null,null,"  e","        "," 141/150","S,V,D,L,I,H,A,N,T,Q"]
[402,"   S",0.044,null,5," 0.044, 0.044",null,null,"    5,5",null,null,"  e","        "," 140/150","N,A,T,Y,S,F,L,H"]
[403,"   P",0.2,null,4," 0.200, 0.200",null,null,"    4,4",null,null,"  e","        "," 140/150","H,P,L,S,N"]
[404,"   S",1.042,null,1," 1.042, 1.042",null,null,"    1,1",null,null,"  e","        "," 141/150","F,S,H,I,P,L,T,A,Y,Q"]
[405,"   T",0.46,null,2," 0.460, 0.460",null,null,"    2,2",null,null,"  e","        "," 140/150","I,M,L,V,S,A,T"]
[406,"   F",-0.344,null,7,"-0.344,-0.344",null,null,"    7,7",null,null,"  b","        "," 141/150","Y,F"]
[407,"   H",-0.519,null,8,"-0.519,-0.519",null,null,"    8,8",null,null,"  b","        "," 141/150","H,Q"]
[408,"   Y",0.548,null,1," 0.548, 0.548",null,null,"    1,1",null,null,"  b","        "," 140/150","F,C,T,S,H,Y,L"]
[409,"   V",-0.615,null,9,"-0.615,-0.615",null,null,"    9,9",null,null,"  b","       s"," 140/150","I,V"]
[410,"   L",-0.456,null,8,"-0.456,-0.456",null,null,"    8,8",null,null,"  b","        "," 140/150","I,L,F,V"]
[411,"   V",-0.411,null,8,"-0.411,-0.411",null,null,"    8,8",null,null,"  b","        "," 140/150","V,T,F,L,I"]
[412,"   N",0.069,null,5," 0.069, 0.069",null,null,"    5,5",null,null,"  b","        "," 140/150","S,C,H,I,T,K,N,R"]
[413,"   S",-0.342,null,7,"-0.342,-0.342",null,null,"    7,7",null,null,"  b","        "," 140/150","L,G,A,V,S"]
[414,"   L",-0.554,null,9,"-0.554,-0.554",null,null,"    9,9",null,null,"  b","       s"," 139/150","T,F,L"]
[415,"   H",0.164,null,4," 0.164, 0.164",null,null,"    4,4",null,null,"  b","        "," 138/150","L,Y,H,N,F"]
[416,"   R",0.156,null,4," 0.156, 0.156",null,null,"    4,4",null,null,"  e","        "," 138/150","Q,R,L,A,K"]
[417,"   I",-0.549,null,9,"-0.549,-0.549",null,null,"    9,9",null,null,"  b","       s"," 140/150","I,T,A,V"]
[418,"   I",-0.317,null,7,"-0.317,-0.317",null,null,"    7,7",null,null,"  b","        "," 140/150","V,F,I"]
[419,"   T",-0.443,null,8,"-0.443,-0.443",null,null,"    8,8",null,null,"  e","       f"," 140/150","H,N,S,K,T"]
[420,"   N",-0.489,null,8,"-0.489,-0.489",null,null,"    8,8",null,null,"  e","       f"," 141/150","N,E,Q"]
[421,"   S",0.613,null,1," 0.613, 0.613",null,null,"    1,1",null,null,"  e","        "," 141/150","T,S,K,A,Q,P,H"]
[422,"   A",-0.129,null,6,"-0.129,-0.129",null,null,"    6,6",null,null,"  e","        "," 141/150","S,D,L,P,I,H,K,A,R"]
[423,"   L",-0.568,null,9,"-0.568,-0.568",null,null,"    9,9",null,null,"  b","       s"," 141/150","L,M,V"]
[424,"   D",2.303,null,1," 2.303, 2.303",null,null,"    1,1",null,null,"  e","        "," 141/150","T,A,Q,R,D,S,H,P,L"]
[425,"   W",-0.581,null,9,"-0.581,-0.581",null,null,"    9,9",null,null,"  e","       f"," 141/150","S,W"]
[426,"   W",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 141/150","W"]
[427,"   P",-0.464,null,8,"-0.464,-0.464",null,null,"    8,8",null,null,"  e","       f"," 141/150","A,P,Q"]
[428,"   K",0.562,null,1," 0.562, 0.562",null,null,"    1,1",null,null,"  e","        "," 141/150","H,D,V,Q,E,R,T,N,K"]
[429,"   I",-0.334,null,7,"-0.334,-0.334",null,null,"    7,7",null,null,"  b","        "," 141/150","T,N,A,V,I,R"]
[430,"   D",0.061,null,5," 0.061, 0.061",null,null,"    5,5",null,null,"  e","        "," 141/150","E,R,N,S,D"]
[431,"   A",0.557,null,1," 0.557, 0.557",null,null,"    1,1",null,null,"  b","        "," 141/150","Y,T,N,K,A,P,M,L,I,V"]
[432,"   V",0.306,null,3," 0.306, 0.306",null,null,"    3,3",null,null,"  b","        "," 141/150","I,M,L,F,V"]
[433,"   Y",-0.428,null,8,"-0.428,-0.428",null,null,"    8,8",null,null,"  b","        "," 141/150","Y,H,N"]
[434,"   C",0.233,null,3," 0.233, 0.233",null,null,"    3,3",null,null,"  b","        "," 141/150","G,Y,T,A,N,P,S,V,C"]
[435,"   H",0.137,null,4," 0.137, 0.137",null,null,"    4,4",null,null,"  e","        "," 141/150","K,S,R,Y,H"]
[436,"   S",-0.377,null,7,"-0.377,-0.377",null,null,"    7,7",null,null,"  b","        "," 141/150","G,A,S"]
[437,"   V",0.664,null,1," 0.664, 0.664",null,null,"    1,1",null,null,"  e","        "," 141/150","G,T,A,H,I,P,L,S,V"]
[438,"   E",-0.024,null,5,"-0.024,-0.024",null,null,"    5,5",null,null,"  e","        "," 141/150","Q,E,D,K,A"]
[439,"   L",-0.445,null,8,"-0.445,-0.445",null,null,"    8,8",null,null,"  b","        "," 141/150","M,L,I,F"]
[440,"   R",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  e","       f"," 141/150","K,R"]
[441,"   N",1,null,1," 1.000, 1.000",null,null,"    1,1",null,null,"  b","        "," 141/150","I,H,L,F,S,V,G,A,N,T"]
[442,"   M",-0.433,null,8,"-0.433,-0.433",null,null,"    8,8",null,null,"  b","        "," 141/150","N,I,L,M"]
[443,"   F",-0.628,null,9,"-0.628,-0.628",null,null,"    9,9",null,null,"  b","       s"," 141/150","V,F"]
[444,"   G",0.062,null,5," 0.062, 0.062",null,null,"    5,5",null,null,"  e","        "," 141/150","T,N,A,G,S,L,M,I"]
[445,"   E",-0.169,null,6,"-0.169,-0.169",null,null,"    6,6",null,null,"  e","        "," 141/150","N,D,E"]
[446,"   T",-0.483,null,8,"-0.483,-0.483",null,null,"    8,8",null,null,"  b","        "," 141/150","T,V,A,I"]
[447,"   L",-0.23,null,7,"-0.230,-0.230",null,null,"    7,7",null,null,"  b","        "," 141/150","L,M,K,V,S,C"]
[448,"   H",-0.205,null,6,"-0.205,-0.205",null,null,"    6,6",null,null,"  e","        "," 141/150","T,K,N,S,H,I,G"]
[449,"   K",-0.318,null,7,"-0.318,-0.318",null,null,"    7,7",null,null,"  e","        "," 141/150","H,L,R,K"]
[450,"   A",-0.242,null,7,"-0.242,-0.242",null,null,"    7,7",null,null,"  b","        "," 140/150","I,L,M,T,V,A"]
[451,"   V",0.679,null,1," 0.679, 0.679",null,null,"    1,1",null,null,"  b","        "," 140/150","S,V,I,M,L,N,A,T,Q"]
[452,"   Q",-0.475,null,8,"-0.475,-0.475",null,null,"    8,8",null,null,"  e","       f"," 139/150","H,Q,R,T,S"]
[453,"   G",0.471,null,2," 0.471, 0.471",null,null,"    2,2",null,null,"  e","        "," 133/150","C,T,A,N,S,G"]
[454,"   C",1.351,null,1," 1.351, 1.351",null,null,"    1,1",null,null,"  b","        "," 132/150","C,F,V,S,M,L,T,A,Y,E"]
[455,"   G",0.848,null,1," 0.848, 0.848",null,null,"    1,1",null,null,"  b","        "," 134/150","P,L,M,H,I,S,V,Q,G,T,N,A"]
[456,"   A",0.626,null,1," 0.626, 0.626",null,null,"    1,1",null,null,"  e","        "," 130/150","V,S,C,T,N,A,Q,E,G,W"]
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[500,"   I",-0.378,null,7,"-0.378,-0.378",null,null,"    7,7",null,null,"  b","        "," 140/150","C,F,T,V,I,L"]
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[530,"   V",-0.613,null,9,"-0.613,-0.613",null,null,"    9,9",null,null,"  b","       s"," 141/150","M,I,V"]
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[553,"   H",-0.548,null,9,"-0.548,-0.548",null,null,"    9,9",null,null,"  e","       f"," 142/150","H,Y,F"]
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[557,"   S",0.141,null,4," 0.141, 0.141",null,null,"    4,4",null,null,"  e","        "," 142/150","T,A,N,K,R,S,H,I,M"]
[558,"   I",-0.505,null,8,"-0.505,-0.505",null,null,"    8,8",null,null,"  b","        "," 142/150","V,I"]
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[561,"   W",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 142/150","W"]
[562,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 142/150","N"]
[563,"   P",-0.438,null,8,"-0.438,-0.438",null,null,"    8,8",null,null,"  e","       f"," 142/150","P,L,M"]
[564,"   D",0.084,null,4," 0.084, 0.084",null,null,"    4,4",null,null,"  e","        "," 142/150","H,E,Q,D,V,A"]
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[569,"   T",-0.442,null,8,"-0.442,-0.442",null,null,"    8,8",null,null,"  b","        "," 143/150","Q,S,A,T,C"]
[570,"   F",-0.628,null,9,"-0.628,-0.628",null,null,"    9,9",null,null,"  b","       s"," 143/150","F,Y"]
[571,"   W",-0.581,null,9,"-0.581,-0.581",null,null,"    9,9",null,null,"  b","       s"," 143/150","F,W"]
[572,"   E",-0.335,null,7,"-0.335,-0.335",null,null,"    7,7",null,null,"  b","        "," 143/150","D,S,K,E"]
[573,"   I",-0.182,null,6,"-0.182,-0.182",null,null,"    6,6",null,null,"  b","        "," 143/150","V,A,F,H,I"]
[574,"   S",-0.62,null,9,"-0.620,-0.620",null,null,"    9,9",null,null,"  b","       s"," 143/150","N,S,G"]
[575,"   S",-0.653,null,9,"-0.653,-0.653",null,null,"    9,9",null,null,"  b","       s"," 143/150","P,S"]
[576,"   Q",-0.571,null,9,"-0.571,-0.571",null,null,"    9,9",null,null,"  e","       f"," 143/150","H,L,Q"]
[577,"   M",-0.537,null,9,"-0.537,-0.537",null,null,"    9,9",null,null,"  b","       s"," 143/150","L,M,A,V"]
[578,"   L",-0.319,null,7,"-0.319,-0.319",null,null,"    7,7",null,null,"  b","        "," 143/150","I,M,L,V,S"]
[579,"   F",0.047,null,5," 0.047, 0.047",null,null,"    5,5",null,null,"  b","        "," 143/150","F,V,S,T,Y,L"]
[580,"   Y",-0.144,null,6,"-0.144,-0.144",null,null,"    6,6",null,null,"  b","        "," 143/150","Q,Y,T,N,K,L,I,S,F,C"]
[581,"   I",-0.549,null,9,"-0.549,-0.549",null,null,"    9,9",null,null,"  b","       s"," 143/150","V,N,M,I"]
[582,"   C",-0.544,null,9,"-0.544,-0.544",null,null,"    9,9",null,null,"  b","       s"," 143/150","S,A,C"]
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[584,"   K",-0.455,null,8,"-0.455,-0.455",null,null,"    8,8",null,null,"  e","       f"," 143/150","R,I,K,F"]
[585,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 143/150","L"]
[586,"   T",-0.503,null,8,"-0.503,-0.503",null,null,"    8,8",null,null,"  b","        "," 143/150","I,T,V,A,F"]
[587,"   S",-0.297,null,7,"-0.297,-0.297",null,null,"    7,7",null,null,"  e","        "," 143/150","S,D,N,A,T,G,Q,E"]
[588,"   H",-0.325,null,7,"-0.325,-0.325",null,null,"    7,7",null,null,"  e","        "," 143/150","N,Q,R,H"]
[589,"   Q",-0.429,null,8,"-0.429,-0.429",null,null,"    8,8",null,null,"  e","       f"," 143/150","Q,L,G,H,N"]
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[834,"   L",-0.046,null,5,"-0.046,-0.046",null,null,"    5,5",null,null,"  b","        "," 126/150","L,P,I,V,F"]
[835,"   Q",-0.159,null,6,"-0.159,-0.159",null,null,"    6,6",null,null,"  e","        "," 135/150","L,I,S,D,Q,A,N,T"]
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[845,"   C",-0.319,null,7,"-0.319,-0.319",null,null,"    7,7",null,null,"  b","        "," 147/150","L,C,S,V,A"]
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[848,"   G",-0.597,null,9,"-0.597,-0.597",null,null,"    9,9",null,null,"  b","       s"," 147/150","R,G"]
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[850,"   V",-0.58,null,9,"-0.580,-0.580",null,null,"    9,9",null,null,"  b","       s"," 146/150","V,I,M"]
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[852,"   L",-0.568,null,9,"-0.568,-0.568",null,null,"    9,9",null,null,"  b","       s"," 146/150","L,F"]
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[854,"   Q",0.241,null,3," 0.241, 0.241",null,null,"    3,3",null,null,"  e","        "," 146/150","I,H,F,C,S,Y,R,Q,A,N,K"]
[855,"   R",0.856,null,1," 0.856, 0.856",null,null,"    1,1",null,null,"  e","        "," 146/150","S,V,C,P,L,H,T,A,K,N,R"]
[856,"   S",0.533,null,2," 0.533, 0.533",null,null,"    2,2",null,null,"  e","        "," 145/150","S,C,F,L,P,I,N,A,T,G,R,Q,Y"]
[857,"   N",3.174,null,1," 3.174, 3.174",null,null,"    1,1",null,null,"  e","        "," 146/150","S,V,H,P,L,T,K,A,N,Q,R"]
[858,"   S",1.787,null,1," 1.787, 1.787",null,null,"    1,1",null,null,"  e","        "," 146/150","K,A,N,T,R,G,E,Q,V,S,I,L,P"]
[859,"   G",2.075,null,1," 2.075, 2.075",null,null,"    1,1",null,null,"  e","        "," 145/150","Q,G,R,T,A,N,K,P,L,I,V,S,C"]
[860,"   L",2.556,null,1," 2.556, 2.556",null,null,"    1,1",null,null,"  e","        "," 143/150","R,G,Q,W,K,A,N,L,P,I,V,S,F"]
[861,"   A",4.146,null,1," 4.146, 4.146",null,null,"    1,1",null,null,"  e","        "," 144/150","V,M,P,N,K,G,R,Q,S,F,D,L,I,H,A,T,Y"]
[862,"   T",2.238,null,1," 2.238, 2.238",null,null,"    1,1",null,null,"  e","        "," 107/150","L,H,I,S,D,F,Y,T,A,P,M,C,Q,E,G,N"]
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[995,"   L",-0.469,null,8,"-0.469,-0.469",null,null,"    8,8",null,null,"  b","        "," 149/150","L,I,T,V,F"]
[996,"   V",-0.617,null,9,"-0.617,-0.617",null,null,"    9,9",null,null,"  b","       s"," 149/150","I,V,T"]
[997,"   R",-0.533,null,8,"-0.533,-0.533",null,null,"    8,8",null,null,"  b","        "," 149/150","K,R"]
[998,"   Y",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","Y"]
[999,"   V",-0.377,null,7,"-0.377,-0.377",null,null,"    7,7",null,null,"  b","        "," 149/150","A,S,V,M,I"]
[1000,"   R",-0.636,null,9,"-0.636,-0.636",null,null,"    9,9",null,null,"  b","       s"," 149/150","R,H"]
[1001,"   V",-0.387,null,8,"-0.387,-0.387",null,null,"    8,8",null,null,"  b","        "," 149/150","V,N,R,I,Y,H"]
[1002,"   L",-0.455,null,8,"-0.455,-0.455",null,null,"    8,8",null,null,"  b","        "," 149/150","R,L,I,V,F"]
[1003,"   G",-0.447,null,8,"-0.447,-0.447",null,null,"    8,8",null,null,"  e","       f"," 149/150","G,E,P,D"]
[1004,"   N",-0.191,null,6,"-0.191,-0.191",null,null,"    6,6",null,null,"  b","        "," 148/150","I,M,P,C,V,S,K,A,N,T"]
[1005,"   M",0.266,null,3," 0.266, 0.266",null,null,"    3,3",null,null,"  b","        "," 149/150","N,T,I,M,L,P,C,S,V"]
[1006,"   V",0.011,null,5," 0.011, 0.011",null,null,"    5,5",null,null,"  b","        "," 147/150","G,R,T,N,K,H,I,M,L,F,V"]
[1007,"   H",0.071,null,5," 0.071, 0.071",null,null,"    5,5",null,null,"  e","        "," 149/150","H,L,F,S,Y,R,Q,N"]
[1008,"   A",0.105,null,4," 0.105, 0.105",null,null,"    4,4",null,null,"  b","        "," 149/150","H,P,F,V,S,Y,G,T,A"]
[1009,"   I",-0.205,null,6,"-0.205,-0.205",null,null,"    6,6",null,null,"  b","        "," 149/150","I,L,T,K,V"]
[1010,"   Q",-0.075,null,5,"-0.075,-0.075",null,null,"    5,5",null,null,"  e","        "," 149/150","R,Q,I,H,L,P,C,S"]
[1011,"   I",-0.449,null,8,"-0.449,-0.449",null,null,"    8,8",null,null,"  b","        "," 149/150","M,I,T,A,N,V"]
[1012,"   K",-0.64,null,9,"-0.640,-0.640",null,null,"    9,9",null,null,"  e","       f"," 149/150","R,K"]
[1013,"   T",-0.281,null,7,"-0.281,-0.281",null,null,"    7,7",null,null,"  e","        "," 149/150","T,A,N,V,C,I"]
[1014,"   K",-0.349,null,7,"-0.349,-0.349",null,null,"    7,7",null,null,"  e","        "," 149/150","R,Q,E,K"]
[1015,"   L",-0.121,null,6,"-0.121,-0.121",null,null,"    6,6",null,null,"  b","        "," 149/150","L,M,F,V"]
[1016,"   C",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","C"]
[1017,"   Q",-0.464,null,8,"-0.464,-0.464",null,null,"    8,8",null,null,"  e","       f"," 149/150","K,N,T,L,Q"]
[1018,"   L",-0.63,null,9,"-0.630,-0.630",null,null,"    9,9",null,null,"  b","       s"," 149/150","V,L"]
[1019,"   V",-0.511,null,8,"-0.511,-0.511",null,null,"    8,8",null,null,"  b","        "," 149/150","V,A,I,L"]
[1020,"   E",0.101,null,4," 0.101, 0.101",null,null,"    4,4",null,null,"  e","        "," 149/150","G,E,Q,D,S,K,T"]
[1021,"   V",0.31,null,3," 0.310, 0.310",null,null,"    3,3",null,null,"  b","        "," 150/150","L,M,I,T,A,K,V"]
[1022,"   M",-0.567,null,9,"-0.567,-0.567",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,M,I,V"]
[1023,"   M",-0.659,null,9,"-0.659,-0.659",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,M"]
[1024,"   A",1.153,null,1," 1.153, 1.153",null,null,"    1,1",null,null,"  e","        "," 150/150","S,V,D,L,T,K,N,A,Q,E,G,R"]
[1025,"   R",-0.431,null,8,"-0.431,-0.431",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,R,C,K,N"]
[1026,"   R",-0.636,null,9,"-0.636,-0.636",null,null,"    9,9",null,null,"  e","       f"," 150/150","R,Y"]
[1027,"   D",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,E"]
[1028,"   D",-0.355,null,7,"-0.355,-0.355",null,null,"    7,7",null,null,"  e","        "," 150/150","E,N,C,D"]
[1029,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L"]
[1030,"   S",-0.327,null,7,"-0.327,-0.327",null,null,"    7,7",null,null,"  e","        "," 150/150","I,L,T,A,S"]
[1031,"   F",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,F"]
[1032,"   C",-0.588,null,9,"-0.588,-0.588",null,null,"    9,9",null,null,"  e","       f"," 150/150","H,R,C"]
[1033,"   Q",-0.617,null,9,"-0.617,-0.617",null,null,"    9,9",null,null,"  e","       f"," 150/150","H,Q,S"]
[1034,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","E"]
[1035,"   M",-0.529,null,8,"-0.529,-0.529",null,null,"    8,8",null,null,"  b","        "," 150/150","V,I,L,M"]
[1036,"   K",-0.463,null,8,"-0.463,-0.463",null,null,"    8,8",null,null,"  e","       f"," 150/150","R,K"]
[1037,"   F",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,F"]
[1038,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","R"]
[1039,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","N"]
[1040,"   K",-0.643,null,9,"-0.643,-0.643",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R"]
[1041,"   M",-0.346,null,7,"-0.346,-0.346",null,null,"    7,7",null,null,"  b","        "," 150/150","L,M,V"]
[1042,"   V",-0.622,null,9,"-0.622,-0.622",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,V,T"]
[1043,"   E",-0.481,null,8,"-0.481,-0.481",null,null,"    8,8",null,null,"  e","       f"," 150/150","E,D"]
[1044,"   Y",-0.624,null,9,"-0.624,-0.624",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,M"]
[1045,"   L",-0.58,null,9,"-0.580,-0.580",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L,V"]
[1046,"   T",-0.418,null,8,"-0.418,-0.418",null,null,"    8,8",null,null,"  b","        "," 150/150","C,T,S,A,L"]
[1047,"   D",-0.587,null,9,"-0.587,-0.587",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,D"]
[1048,"   W",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","W"]
[1049,"   V",-0.221,null,6,"-0.221,-0.221",null,null,"    6,6",null,null,"  b","        "," 150/150","L,I,A,V,C"]
[1050,"   M",-0.482,null,8,"-0.482,-0.482",null,null,"    8,8",null,null,"  b","        "," 150/150","I,M,L"]
[1051,"   G",-0.039,null,5,"-0.039,-0.039",null,null,"    5,5",null,null,"  b","        "," 150/150","V,N,C,D,G,P,W"]
[1052,"   T",0.31,null,3," 0.310, 0.310",null,null,"    3,3",null,null,"  e","        "," 150/150","T,N,A,E,R,G,F,V,S,I"]
[1053,"   S",-0.309,null,7,"-0.309,-0.309",null,null,"    7,7",null,null,"  e","        "," 150/150","H,P,G,T,S,N,A"]
[1054,"   N",-0.241,null,7,"-0.241,-0.241",null,null,"    7,7",null,null,"  e","        "," 150/150","A,N,G,E,S,L,P,H"]
[1055,"   Q",0.045,null,5," 0.045, 0.045",null,null,"    5,5",null,null,"  e","        "," 150/150","Q,N,A,K,P,L,H,I,S,V,D,F"]
[1056,"   A",0.772,null,1," 0.772, 0.772",null,null,"    1,1",null,null,"  e","        "," 139/150","T,K,A,Q,G,R,S,I,P"]
[1057,"   A",1.051,null,1," 1.051, 1.051",null,null,"    1,1",null,null,"  e","        "," 150/150","A,N,T,G,S,V,I,H,L,P"]
[1058,"   D",0.785,null,1," 0.785, 0.785",null,null,"    1,1",null,null,"  e","        "," 147/150","T,N,A,Q,R,G,Y,S,V,D,P,L,I"]
[1059,"   D",1.855,null,1," 1.855, 1.855",null,null,"    1,1",null,null,"  e","        "," 150/150","S,V,D,G,E,Y,A,N,T"]
[1060,"   D",-0.233,null,7,"-0.233,-0.233",null,null,"    7,7",null,null,"  e","        "," 150/150","Q,P,E,D,C,F,N"]
[1061,"   V",0.7,null,1," 0.700, 0.700",null,null,"    1,1",null,null,"  b","        "," 150/150","N,A,T,W,G,F,S,V,I,L,M,P"]
[1062,"   K",0.503,null,2," 0.503, 0.503",null,null,"    2,2",null,null,"  e","        "," 149/150","T,X,A,K,G,V,S,C,L,I"]
[1063,"   C",1.738,null,1," 1.738, 1.738",null,null,"    1,1",null,null,"  b","        "," 147/150","A,T,G,E,Q,S,V,C,D,L,M,P,I"]
[1064,"   L",0.2,null,4," 0.200, 0.200",null,null,"    4,4",null,null,"  b","        "," 150/150","S,V,F,L,M,I,A,Q,Y"]
[1065,"   T",-0.143,null,6,"-0.143,-0.143",null,null,"    6,6",null,null,"  b","        "," 149/150","V,S,F,L,I,T,A,Q"]
[1066,"   R",-0.491,null,8,"-0.491,-0.491",null,null,"    8,8",null,null,"  e","       f"," 149/150","R,G,T,K"]
[1067,"   D",-0.212,null,6,"-0.212,-0.212",null,null,"    6,6",null,null,"  e","        "," 150/150","E,D,V"]
[1068,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,F"]
[1069,"   D",-0.539,null,9,"-0.539,-0.539",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,N,E"]
[1070,"   Q",-0.317,null,7,"-0.317,-0.317",null,null,"    7,7",null,null,"  e","        "," 150/150","I,M,L,T,A,Y,E,Q"]
[1071,"   A",-0.431,null,8,"-0.431,-0.431",null,null,"    8,8",null,null,"  b","        "," 150/150","W,L,A,S,T"]
[1072,"   S",-0.389,null,8,"-0.389,-0.389",null,null,"    8,8",null,null,"  b","        "," 150/150","C,V,A,S"]
[1073,"   M",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","M"]
[1074,"   E",-0.17,null,6,"-0.170,-0.170",null,null,"    6,6",null,null,"  e","        "," 150/150","D,A,V,H,E,Q,R"]
[1075,"   A",-0.608,null,9,"-0.608,-0.608",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,C,G"]
[1076,"   V",-0.583,null,9,"-0.583,-0.583",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L,M,V"]
[1077,"   V",-0.42,null,8,"-0.420,-0.420",null,null,"    8,8",null,null,"  b","        "," 150/150","G,E,A,V"]
[1078,"   S",-0.38,null,7,"-0.380,-0.380",null,null,"    7,7",null,null,"  b","        "," 150/150","S,A"]
[1079,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1080,"   L",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 150/150","M,L"]
[1081,"   A",0.286,null,3," 0.286, 0.286",null,null,"    3,3",null,null,"  e","        "," 150/150","L,H,V,S,R,Q,K,A"]
[1082,"   G",-0.089,null,6,"-0.089,-0.089",null,null,"    6,6",null,null,"  e","        "," 150/150","D,S,A,E,G"]
[1083,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,M"]
[1084,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","P"]
[1085,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","L"]
[1086,"   Q",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q"]
[1087,"   P",-0.586,null,9,"-0.586,-0.586",null,null,"    9,9",null,null,"  e","       f"," 149/150","P,S,X"]
[1088,"   E",-0.636,null,9,"-0.636,-0.636",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,Q"]
[1089,"   E",-0.518,null,8,"-0.518,-0.518",null,null,"    8,8",null,null,"  e","       f"," 150/150","G,E,D,T"]
[1090,"   G",-0.39,null,8,"-0.390,-0.390",null,null,"    8,8",null,null,"  e","       f"," 150/150","T,S,N,M,G,I"]
[1091,"   D",-0.569,null,9,"-0.569,-0.569",null,null,"    9,9",null,null,"  e","       f"," 150/150","V,D,E"]
[1092,"   G",-0.397,null,8,"-0.397,-0.397",null,null,"    8,8",null,null,"  e","       f"," 148/150","R,G,Q,A,C"]
[1093,"   V",0.016,null,5," 0.016, 0.016",null,null,"    5,5",null,null,"  b","        "," 150/150","C,V,P,N,A,T,G,R"]
[1094,"   E",-0.367,null,7,"-0.367,-0.367",null,null,"    7,7",null,null,"  e","        "," 150/150","E,N,T,D"]
[1095,"   L",-0.362,null,7,"-0.362,-0.362",null,null,"    7,7",null,null,"  b","        "," 150/150","M,L,P,I,V,A"]
[1096,"   M",-0.572,null,9,"-0.572,-0.572",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,M,V,N,K"]
[1097,"   E",-0.34,null,7,"-0.340,-0.340",null,null,"    7,7",null,null,"  e","        "," 150/150","D,L,G,E"]
[1098,"   A",-0.597,null,9,"-0.597,-0.597",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,N,A"]
[1099,"   K",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","K"]
[1100,"   S",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","S"]
[1101,"   Q",-0.465,null,8,"-0.465,-0.465",null,null,"    8,8",null,null,"  e","       f"," 150/150","T,K,A,H,E,Q"]
[1102,"   L",-0.579,null,9,"-0.579,-0.579",null,null,"    9,9",null,null,"  b","       s"," 150/150","M,L"]
[1103,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1104,"   L",-0.482,null,8,"-0.482,-0.482",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,L,A,S"]
[1105,"   K",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 149/150","K"]
[1106,"   Y",-0.568,null,9,"-0.568,-0.568",null,null,"    9,9",null,null,"  b","       s"," 149/150","Y,H,F"]
[1107,"   F",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 149/150","F,L"]
[1108,"   T",-0.348,null,7,"-0.348,-0.348",null,null,"    7,7",null,null,"  b","        "," 149/150","S,T,M,G,I"]
[1109,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 149/150","L,M"]
[1110,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","F"]
[1111,"   M",-0.603,null,9,"-0.603,-0.603",null,null,"    9,9",null,null,"  b","       s"," 149/150","K,I,L,M"]
[1112,"   N",-0.539,null,9,"-0.539,-0.539",null,null,"    9,9",null,null,"  e","       f"," 148/150","X,K,N"]
[1113,"   L",-0.514,null,8,"-0.514,-0.514",null,null,"    8,8",null,null,"  b","        "," 148/150","L,S,X,V,F"]
[1114,"   L",-0.461,null,8,"-0.461,-0.461",null,null,"    8,8",null,null,"  b","        "," 148/150","X,I,L,M"]
[1115,"   N",-0.577,null,9,"-0.577,-0.577",null,null,"    9,9",null,null,"  e","       f"," 147/150","G,D,X,N,S"]
[1116,"   D",-0.046,null,5,"-0.046,-0.046",null,null,"    5,5",null,null,"  e","        "," 148/150","R,G,E,Y,H,C,D"]
[1117,"   C",-0.497,null,8,"-0.497,-0.497",null,null,"    8,8",null,null,"  b","        "," 148/150","E,V,C"]
[1118,"   S",0.369,null,3," 0.369, 0.369",null,null,"    3,3",null,null,"  e","        "," 149/150","G,R,T,A,N,K,H,I,M,V,S"]
[1119,"   E",0.378,null,3," 0.378, 0.378",null,null,"    3,3",null,null,"  e","        "," 149/150","D,S,K,G,M,E"]
[1120,"   V",1.335,null,1," 1.335, 1.335",null,null,"    1,1",null,null,"  e","        "," 148/150","S,V,D,L,P,I,A,N,T,R,G,E"]
[1121,"   E",0.965,null,1," 0.965, 0.965",null,null,"    1,1",null,null,"  e","        "," 147/150","L,P,I,S,V,R,G,E,Q,N,K,A,T"]
[1122,"   D",1.566,null,1," 1.566, 1.566",null,null,"    1,1",null,null,"  e","        "," 147/150","A,N,T,G,Q,E,D,S,I,L,M,P"]
[1123,"   E",2.292,null,1," 2.292, 2.292",null,null,"    1,1",null,null,"  e","        "," 117/150","D,V,I,L,T,K,A,Q,E,G"]
[1124,"   S",1.016,null,1," 1.016, 1.016",null,null,"    1,1",null,null,"  e","        "," 147/150","K,S,N,C,D,G,E"]
[1125,"   A",0.431,null,2," 0.431, 0.431",null,null,"    2,2",null,null,"  e","        "," 143/150","D,S,K,A,T,G,Q,E"]
[1126,"   Q",1.025,null,1," 1.025, 1.025",null,null,"    1,1",null,null,"  e","        "," 143/150","C,D,S,V,P,K,A,N,T,R,Q,E"]
[1127,"   T",1.135,null,1," 1.135, 1.135",null,null,"    1,1",null,null,"  e","        "," 131/150","P,M,L,I,V,S,D,E,Q,G,T,A"]
[1128,"   G",1.47,null,1," 1.470, 1.470",null,null,"    1,1",null,null,"  e","        "," 132/150","A,N,T,G,E,D,V,S,I,M"]
[1129,"   G",1.41,null,1," 1.410, 1.410",null,null,"    1,1",null,null,"  e","        "," 134/150","E,Q,R,G,T,N,K,P,L,S,V,D,C"]
[1130,"   R",0.74,null,1," 0.740, 0.740",null,null,"    1,1",null,null,"  e","        "," 135/150","E,Q,G,R,T,K,A,N,P,H,I,S,F"]
[1131,"   K",0.948,null,1," 0.948, 0.948",null,null,"    1,1",null,null,"  e","        "," 125/150","Y,Q,G,R,T,K,H,P,L,S,V"]
[1132,"   R",1.032,null,1," 1.032, 1.032",null,null,"    1,1",null,null,"  e","        "," 142/150","T,K,N,A,Q,E,G,R,D,F,C,V,S,H,P"]
[1133,"   G",2.246,null,1," 2.246, 2.246",null,null,"    1,1",null,null,"  e","        "," 143/150","K,A,T,R,G,Q,F,V,S,I,L,M"]
[1134,"   M",1.369,null,1," 1.369, 1.369",null,null,"    1,1",null,null,"  e","        "," 145/150","E,Q,R,G,Y,T,K,N,A,P,M,L,H,I,S"]
[1135,"   S",0.722,null,1," 0.722, 0.722",null,null,"    1,1",null,null,"  e","        "," 147/150","T,A,N,E,G,R,V,S,H,I,P,M,L"]
[1136,"   R",1.487,null,1," 1.487, 1.487",null,null,"    1,1",null,null,"  e","        "," 149/150","K,A,N,T,R,G,E,Q,Y,V,S,D,P"]
[1137,"   R",0.017,null,5," 0.017, 0.017",null,null,"    5,5",null,null,"  e","        "," 149/150","S,V,Q,E,R,A,K,N"]
[1138,"   L",-0.012,null,5,"-0.012,-0.012",null,null,"    5,5",null,null,"  b","        "," 149/150","V,S,L,M,H,I,T,N,Q"]
[1139,"   A",0.393,null,2," 0.393, 0.393",null,null,"    2,2",null,null,"  e","        "," 149/150","D,S,I,L,T,A,N,E,Q,G"]
[1140,"   S",0.282,null,3," 0.282, 0.282",null,null,"    3,3",null,null,"  e","        "," 150/150","S,V,D,C,M,I,T,N,A,Q,E"]
[1141,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1142,"   R",-0.488,null,8,"-0.488,-0.488",null,null,"    8,8",null,null,"  e","       f"," 150/150","H,P,R"]
[1143,"   H",-0.111,null,6,"-0.111,-0.111",null,null,"    6,6",null,null,"  e","        "," 150/150","R,Q,N,K,T,H,F,D,S"]
[1144,"   C",0.129,null,4," 0.129, 0.129",null,null,"    4,4",null,null,"  b","        "," 150/150","T,N,A,Y,G,F,C,S,V"]
[1145,"   T",-0.617,null,9,"-0.617,-0.617",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,T"]
[1146,"   V",-0.496,null,8,"-0.496,-0.496",null,null,"    8,8",null,null,"  b","        "," 150/150","V,L,I"]
[1147,"   L",-0.458,null,8,"-0.458,-0.458",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,L,T"]
[1148,"   A",-0.608,null,9,"-0.608,-0.608",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,S"]
[1149,"   M",-0.659,null,9,"-0.659,-0.659",null,null,"    9,9",null,null,"  b","       s"," 150/150","T,M"]
[1150,"   S",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","S"]
[1151,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","N"]
[1152,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1153,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1154,"   N",-0.504,null,8,"-0.504,-0.504",null,null,"    8,8",null,null,"  e","       f"," 150/150","S,A,N,G"]
[1155,"   A",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","A"]
[1156,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","N"]
[1157,"   V",-0.564,null,9,"-0.564,-0.564",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,V"]
[1158,"   D",-0.584,null,9,"-0.584,-0.584",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,E"]
[1159,"   S",-0.615,null,9,"-0.615,-0.615",null,null,"    9,9",null,null,"  e","       f"," 150/150","T,S,I"]
[1160,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","G"]
[1161,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1162,"   M",-0.324,null,7,"-0.324,-0.324",null,null,"    7,7",null,null,"  b","        "," 150/150","V,T,M,R,Q"]
[1163,"   H",-0.607,null,9,"-0.607,-0.607",null,null,"    9,9",null,null,"  b","       s"," 150/150","H,Y,T"]
[1164,"   S",-0.621,null,9,"-0.621,-0.621",null,null,"    9,9",null,null,"  b","       s"," 150/150","S,A"]
[1165,"   I",-0.625,null,9,"-0.625,-0.625",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,I,V"]
[1166,"   G",0.149,null,4," 0.149, 0.149",null,null,"    4,4",null,null,"  b","        "," 150/150","A,S,D,R,G,E,H"]
[1167,"   L",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,M"]
[1168,"   G",-0.521,null,8,"-0.521,-0.521",null,null,"    8,8",null,null,"  b","        "," 150/150","G,A"]
[1169,"   Y",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","Y"]
[1170,"   H",-0.565,null,9,"-0.565,-0.565",null,null,"    9,9",null,null,"  e","       f"," 150/150","H,N,K,D"]
[1171,"   K",0.352,null,3," 0.352, 0.352",null,null,"    3,3",null,null,"  e","        "," 150/150","Q,R,T,K,A,P,S,D"]
[1172,"   D",-0.637,null,9,"-0.637,-0.637",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,E"]
[1173,"   L",-0.358,null,7,"-0.358,-0.358",null,null,"    7,7",null,null,"  e","        "," 150/150","V,R,L,P"]
[1174,"   Q",-0.617,null,9,"-0.617,-0.617",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q,R,K"]
[1175,"   T",-0.616,null,9,"-0.616,-0.616",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,S,T"]
[1176,"   R",-0.638,null,9,"-0.638,-0.638",null,null,"    9,9",null,null,"  b","       s"," 150/150","K,R"]
[1177,"   A",-0.526,null,8,"-0.526,-0.526",null,null,"    8,8",null,null,"  b","        "," 150/150","T,A,V"]
[1178,"   T",-0.569,null,9,"-0.569,-0.569",null,null,"    9,9",null,null,"  e","       f"," 150/150","V,S,A,T"]
[1179,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1180,"   M",-0.539,null,9,"-0.539,-0.539",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,M,I"]
[1181,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","E"]
[1182,"   V",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","V"]
[1183,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1184,"   T",-0.617,null,9,"-0.617,-0.617",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,T,R"]
[1185,"   K",-0.458,null,8,"-0.458,-0.458",null,null,"    8,8",null,null,"  e","       f"," 150/150","K,Q,R"]
[1186,"   I",-0.656,null,9,"-0.656,-0.656",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,T"]
[1187,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1188,"   Q",-0.582,null,9,"-0.582,-0.582",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,L,Q"]
[1189,"   Q",-0.652,null,9,"-0.652,-0.652",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,Q"]
[1190,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","G"]
[1191,"   T",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","T"]
[1192,"   E",-0.586,null,9,"-0.586,-0.586",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q,E"]
[1193,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1194,"   D",-0.582,null,9,"-0.582,-0.582",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,D"]
[1195,"   T",-0.618,null,9,"-0.618,-0.618",null,null,"    9,9",null,null,"  e","       f"," 150/150","M,N,T"]
[1196,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1197,"   A",-0.641,null,9,"-0.641,-0.641",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,N"]
[1198,"   E",-0.585,null,9,"-0.585,-0.585",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,E"]
[1199,"   T",-0.617,null,9,"-0.617,-0.617",null,null,"    9,9",null,null,"  b","       s"," 150/150","T,S"]
[1200,"   V",-0.516,null,8,"-0.516,-0.516",null,null,"    8,8",null,null,"  b","        "," 150/150","A,V"]
[1201,"   L",-0.472,null,8,"-0.472,-0.472",null,null,"    8,8",null,null,"  b","        "," 150/150","F,M,L"]
[1202,"   A",-0.565,null,9,"-0.565,-0.565",null,null,"    9,9",null,null,"  e","       f"," 150/150","A,S,H,M"]
[1203,"   D",-0.635,null,9,"-0.635,-0.635",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,E"]
[1204,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","R"]
[1205,"   F",-0.461,null,8,"-0.461,-0.461",null,null,"    8,8",null,null,"  b","        "," 150/150","F,Y"]
[1206,"   E",-0.481,null,8,"-0.481,-0.481",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,E,R,D"]
[1207,"   R",-0.558,null,9,"-0.558,-0.558",null,null,"    9,9",null,null,"  e","       f"," 150/150","R,Q,E,K"]
[1208,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1209,"   V",-0.654,null,9,"-0.654,-0.654",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,I"]
[1210,"   E",-0.283,null,7,"-0.283,-0.283",null,null,"    7,7",null,null,"  e","        "," 150/150","G,L,Q,E,K,D"]
[1211,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1212,"   V",-0.511,null,8,"-0.511,-0.511",null,null,"    8,8",null,null,"  b","        "," 150/150","I,M,L,T,V,A"]
[1213,"   T",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","T"]
[1214,"   M",-0.6,null,9,"-0.600,-0.600",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L,M"]
[1215,"   M",-0.446,null,8,"-0.446,-0.446",null,null,"    8,8",null,null,"  b","        "," 150/150","T,V,I,Q,M,L"]
[1216,"   G",-0.521,null,8,"-0.521,-0.521",null,null,"    8,8",null,null,"  e","       f"," 150/150","G,S,T"]
[1217,"   D",-0.397,null,8,"-0.397,-0.397",null,null,"    8,8",null,null,"  e","       f"," 150/150","D,V,E"]
[1218,"   Q",-0.495,null,8,"-0.495,-0.495",null,null,"    8,8",null,null,"  e","       f"," 150/150","K,N,D,R,Q"]
[1219,"   G",-0.437,null,8,"-0.437,-0.437",null,null,"    8,8",null,null,"  e","       f"," 150/150","G,E,S,N"]
[1220,"   E",-0.533,null,8,"-0.533,-0.533",null,null,"    8,8",null,null,"  e","       f"," 150/150","E,K,D"]
[1221,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1222,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","P"]
[1223,"   I",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","I"]
[1224,"   A",-0.608,null,9,"-0.608,-0.608",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,A"]
[1225,"   M",-0.539,null,9,"-0.539,-0.539",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,N,M,I"]
[1226,"   A",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","A"]
[1227,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1228,"   A",-0.566,null,9,"-0.566,-0.566",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,S,T"]
[1229,"   N",-0.061,null,5,"-0.061,-0.061",null,null,"    5,5",null,null,"  e","        "," 150/150","T,N,S,D,Q,H,Y"]
[1230,"   V",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","V"]
[1231,"   V",-0.524,null,8,"-0.524,-0.524",null,null,"    8,8",null,null,"  b","        "," 149/150","T,V,I"]
[1232,"   P",0.265,null,3," 0.265, 0.265",null,null,"    3,3",null,null,"  b","        "," 148/150","G,Q,A,N,T,L,M,P,S,V"]
[1233,"   C",0.189,null,4," 0.189, 0.189",null,null,"    4,4",null,null,"  b","        "," 149/150","F,C,S,P,T,N,A,R,G"]
[1234,"   S",0.082,null,4," 0.082, 0.082",null,null,"    4,4",null,null,"  e","        "," 149/150","T,N,A,Q,E,G,S,D,P,L,H"]
[1235,"   Q",-0.544,null,9,"-0.544,-0.544",null,null,"    9,9",null,null,"  e","       f"," 149/150","H,Q,E,N"]
[1236,"   W",-0.625,null,9,"-0.625,-0.625",null,null,"    9,9",null,null,"  b","       s"," 149/150","M,L,W"]
[1237,"   D",-0.637,null,9,"-0.637,-0.637",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,N"]
[1238,"   E",-0.635,null,9,"-0.635,-0.635",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,E"]
[1239,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1240,"   A",-0.529,null,8,"-0.529,-0.529",null,null,"    8,8",null,null,"  b","        "," 150/150","S,A"]
[1241,"   R",-0.638,null,9,"-0.638,-0.638",null,null,"    9,9",null,null,"  e","       f"," 150/150","H,R"]
[1242,"   V",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","V"]
[1243,"   L",-0.3,null,7,"-0.300,-0.300",null,null,"    7,7",null,null,"  b","        "," 150/150","F,Y,L"]
[1244,"   V",-0.654,null,9,"-0.654,-0.654",null,null,"    9,9",null,null,"  b","       s"," 150/150","T,V"]
[1245,"   T",-0.434,null,8,"-0.434,-0.434",null,null,"    8,8",null,null,"  b","        "," 150/150","I,M,T,N,A,S"]
[1246,"   L",-0.413,null,8,"-0.413,-0.413",null,null,"    8,8",null,null,"  b","        "," 150/150","I,L,F,V"]
[1247,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1248,"   D",-0.585,null,9,"-0.585,-0.585",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,S,D"]
[1249,"   S",-0.482,null,8,"-0.482,-0.482",null,null,"    8,8",null,null,"  b","        "," 150/150","D,S,A"]
[1250,"   R",-0.553,null,9,"-0.553,-0.553",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R"]
[1251,"   H",-0.446,null,8,"-0.446,-0.446",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,R,H,N,K"]
[1252,"   L",-0.472,null,8,"-0.472,-0.472",null,null,"    8,8",null,null,"  b","        "," 150/150","L,M,I,H,N"]
[1253,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1254,"   Y",-0.204,null,6,"-0.204,-0.204",null,null,"    6,6",null,null,"  b","        "," 150/150","P,H,S,C,G,E,Y,A,T"]
[1255,"   Q",-0.241,null,7,"-0.241,-0.241",null,null,"    7,7",null,null,"  e","        "," 150/150","H,Q,E,P,S"]
[1256,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,M"]
[1257,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,L"]
[1258,"   W",-0.24,null,7,"-0.240,-0.240",null,null,"    7,7",null,null,"  e","        "," 150/150","I,W,L,C,N"]
[1259,"   N",-0.614,null,9,"-0.614,-0.614",null,null,"    9,9",null,null,"  e","       f"," 150/150","N,K"]
[1260,"   M",-0.536,null,9,"-0.536,-0.536",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,V,I,M,L"]
[1261,"   F",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,L"]
[1262,"   S",-0.422,null,8,"-0.422,-0.422",null,null,"    8,8",null,null,"  e","       f"," 150/150","M,I,Y,A,S,N"]
[1263,"   K",-0.449,null,8,"-0.449,-0.449",null,null,"    8,8",null,null,"  e","       f"," 150/150","M,R,K"]
[1264,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","E"]
[1265,"   V",-0.653,null,9,"-0.653,-0.653",null,null,"    9,9",null,null,"  b","       s"," 149/150","A,V"]
[1266,"   E",-0.575,null,9,"-0.575,-0.575",null,null,"    9,9",null,null,"  e","       f"," 149/150","E,Y,D"]
[1267,"   L",-0.086,null,6,"-0.086,-0.086",null,null,"    6,6",null,null,"  b","        "," 150/150","L,I,A,K,S,V"]
[1268,"   A",-0.437,null,8,"-0.437,-0.437",null,null,"    8,8",null,null,"  b","        "," 150/150","T,A,S,I"]
[1269,"   D",-0.537,null,9,"-0.537,-0.537",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,D"]
[1270,"   S",-0.402,null,8,"-0.402,-0.402",null,null,"    8,8",null,null,"  b","        "," 150/150","C,S,A,G"]
[1271,"   M",-0.529,null,8,"-0.529,-0.529",null,null,"    8,8",null,null,"  b","        "," 150/150","I,L,M,P"]
[1272,"   Q",-0.471,null,8,"-0.471,-0.471",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,H,S,T"]
[1273,"   T",-0.652,null,9,"-0.652,-0.652",null,null,"    9,9",null,null,"  b","       s"," 150/150","T,S"]
[1274,"   L",-0.574,null,9,"-0.574,-0.574",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,L,P"]
[1275,"   F",-0.58,null,9,"-0.580,-0.580",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,L"]
[1276,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","R"]
[1277,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","G"]
[1278,"   N",-0.65,null,9,"-0.650,-0.650",null,null,"    9,9",null,null,"  e","       f"," 150/150","N,S"]
[1279,"   S",-0.594,null,9,"-0.594,-0.594",null,null,"    9,9",null,null,"  e","       f"," 150/150","S,T"]
[1280,"   L",-0.575,null,9,"-0.575,-0.575",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,L,M"]
[1281,"   A",-0.347,null,7,"-0.347,-0.347",null,null,"    7,7",null,null,"  b","        "," 150/150","A,S,T,G"]
[1282,"   S",-0.656,null,9,"-0.656,-0.656",null,null,"    9,9",null,null,"  b","       s"," 150/150","S,C"]
[1283,"   K",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","K"]
[1284,"   I",-0.592,null,9,"-0.592,-0.592",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L,V,T"]
[1285,"   M",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","M"]
[1286,"   T",-0.365,null,7,"-0.365,-0.365",null,null,"    7,7",null,null,"  b","        "," 150/150","G,T,N,A,S"]
[1287,"   F",-0.129,null,6,"-0.129,-0.129",null,null,"    6,6",null,null,"  b","        "," 150/150","L,Y,A,V,C,F"]
[1288,"   C",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","C"]
[1289,"   F",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,Y"]
[1290,"   K",-0.553,null,9,"-0.553,-0.553",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R"]
[1291,"   V",-0.366,null,7,"-0.366,-0.366",null,null,"    7,7",null,null,"  b","        "," 150/150","F,V,A,I,M,L,Q"]
[1292,"   Y",-0.508,null,8,"-0.508,-0.508",null,null,"    8,8",null,null,"  e","       f"," 150/150","F,Y"]
[1293,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","G"]
[1294,"   A",-0.026,null,5,"-0.026,-0.026",null,null,"    5,5",null,null,"  b","        "," 150/150","S,H,T,N,A,Y,Q,R,G"]
[1295,"   T",0.076,null,5," 0.076, 0.076",null,null,"    5,5",null,null,"  e","        "," 150/150","G,W,T,K,A,N,L,V,S,D"]
[1296,"   Y",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,Y"]
[1297,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L"]
[1298,"   Q",-0.138,null,6,"-0.138,-0.138",null,null,"    6,6",null,null,"  e","        "," 150/150","Q,L,R,H,S,K,C"]
[1299,"   K",0.809,null,1," 0.809, 0.809",null,null,"    1,1",null,null,"  e","        "," 150/150","A,N,K,T,G,E,D,S,L,M"]
[1300,"   L",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,V"]
[1301,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1302,"   D",0.395,null,2," 0.395, 0.395",null,null,"    2,2",null,null,"  e","        "," 150/150","D,F,S,H,L,T,N,A,Q,E,G"]
[1303,"   P",-0.459,null,8,"-0.459,-0.459",null,null,"    8,8",null,null,"  e","       f"," 149/150","D,G,P"]
[1304,"   L",-0.153,null,6,"-0.153,-0.153",null,null,"    6,6",null,null,"  b","        "," 150/150","H,I,E,M,L,F,S"]
[1305,"   L",-0.405,null,8,"-0.405,-0.405",null,null,"    8,8",null,null,"  b","        "," 150/150","V,T,L,I"]
[1306,"   R",1.652,null,1," 1.652, 1.652",null,null,"    1,1",null,null,"  e","        "," 150/150","S,L,M,I,T,K,N,A,E,Q,R"]
[1307,"   I",1.754,null,1," 1.754, 1.754",null,null,"    1,1",null,null,"  e","        "," 150/150","R,G,E,Q,A,T,I,L,P,F,D,V,S"]
[1308,"   V",-0.135,null,6,"-0.135,-0.135",null,null,"    6,6",null,null,"  b","        "," 150/150","W,N,T,L,M,I,V,F"]
[1309,"   I",0.484,null,2," 0.484, 0.484",null,null,"    2,2",null,null,"  b","        "," 150/150","F,V,I,L,M,T,A,Y,Q"]
[1310,"   T",1.094,null,1," 1.094, 1.094",null,null,"    1,1",null,null,"  e","        "," 150/150","H,I,M,D,S,V,Q,E,R,G,T,N,K"]
[1311,"   S",1.588,null,1," 1.588, 1.588",null,null,"    1,1",null,null,"  e","        "," 150/150","D,S,H,I,P,M,L,T,K,A,N,Q,E,G"]
[1312,"   S",2.548,null,1," 2.548, 2.548",null,null,"    1,1",null,null,"  e","        "," 146/150","C,S,L,M,P,N,A,T,G,E,Q"]
[1313,"   D",2.551,null,1," 2.551, 2.551",null,null,"    1,1",null,null,"  e","        ","  56/150","T,A,D,E,R,H"]
[1314,"   W",1.336,null,1," 1.336, 1.336",null,null,"    1,1",null,null,"  b","        ","  48/150","S,A,C,W"]
[1315,"   Q",0.005,null,5," 0.005, 0.005",null,null,"    5,5",null,null,"  e","        ","  47/150","N,H,Q"]
[1316,"   H",2.025,null,1," 2.025, 2.025",null,null,"    1,1",null,null,"  e","        "," 150/150","M,P,C,V,R,G,E,Q,N,K,H,L,D,S,Y,T"]
[1317,"   V",0.742,null,1," 0.742, 0.742",null,null,"    1,1",null,null,"  b","        "," 150/150","Q,N,A,K,T,I,L,M,P,C,S,V"]
[1318,"   S",-0.237,null,7,"-0.237,-0.237",null,null,"    7,7",null,null,"  b","        "," 150/150","M,H,S,C,F,G,R,N"]
[1319,"   F",-0.224,null,6,"-0.224,-0.224",null,null,"    6,6",null,null,"  b","        "," 150/150","Y,L,F"]
[1320,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","E"]
[1321,"   V",-0.524,null,8,"-0.524,-0.524",null,null,"    8,8",null,null,"  b","        "," 150/150","V,I"]
[1322,"   D",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","D"]
[1323,"   P",0.167,null,4," 0.167, 0.167",null,null,"    4,4",null,null,"  e","        "," 150/150","S,D,P,A,N,T,G,Q"]
[1324,"   T",-0.248,null,7,"-0.248,-0.248",null,null,"    7,7",null,null,"  e","        "," 150/150","A,S,T,R"]
[1325,"   R",-0.588,null,9,"-0.588,-0.588",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R,L"]
[1326,"   L",-0.357,null,7,"-0.357,-0.357",null,null,"    7,7",null,null,"  b","        "," 150/150","M,L,I,T,F"]
[1327,"   E",0.489,null,2," 0.489, 0.489",null,null,"    2,2",null,null,"  e","        "," 150/150","H,Y,E,Q,P,D,S"]
[1328,"   P",4.093,null,1," 4.093, 4.093",null,null,"    1,1",null,null,"  e","        "," 150/150","I,H,L,P,D,S,V,G,Q,N,K,A,T"]
[1329,"   S",2.508,null,1," 2.508, 2.508",null,null,"    1,1",null,null,"  e","        "," 150/150","F,D,S,H,K,A,N,T,R,G,E"]
[1330,"   E",-0.205,null,6,"-0.205,-0.205",null,null,"    6,6",null,null,"  e","        "," 150/150","Q,E,D"]
[1331,"   S",0.605,null,1," 0.605, 0.605",null,null,"    1,1",null,null,"  e","        "," 150/150","V,S,C,D,M,L,I,N,T,E"]
[1332,"   L",-0.323,null,7,"-0.323,-0.323",null,null,"    7,7",null,null,"  b","        "," 150/150","I,M,L,V"]
[1333,"   E",0.139,null,4," 0.139, 0.139",null,null,"    4,4",null,null,"  e","        "," 150/150","I,P,D,G,E,Q,A,K,N"]
[1334,"   E",1.417,null,1," 1.417, 1.417",null,null,"    1,1",null,null,"  e","        "," 150/150","M,H,I,V,S,D,Q,E,R,T,K,A,N"]
[1335,"   N",-0.539,null,9,"-0.539,-0.539",null,null,"    9,9",null,null,"  e","       f"," 150/150","H,Y,N"]
[1336,"   Q",-0.172,null,6,"-0.172,-0.172",null,null,"    6,6",null,null,"  e","        "," 150/150","H,Q,R,G,T,K,S"]
[1337,"   R",2.137,null,1," 2.137, 2.137",null,null,"    1,1",null,null,"  e","        "," 150/150","R,G,Q,E,K,N,A,T,L,M,C,D,S"]
[1338,"   N",-0.317,null,7,"-0.317,-0.317",null,null,"    7,7",null,null,"  e","        "," 150/150","N,S,K,R,H,Y"]
[1339,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,L"]
[1340,"   L",0.105,null,4," 0.105, 0.105",null,null,"    4,4",null,null,"  b","        "," 150/150","I,R,M,L,V,A,T"]
[1341,"   Q",1.29,null,1," 1.290, 1.290",null,null,"    1,1",null,null,"  e","        "," 149/150","R,E,Q,K,A,N,T,L,M,I,V,S,F,D"]
[1342,"   M",-0.022,null,5,"-0.022,-0.022",null,null,"    5,5",null,null,"  b","        "," 149/150","A,F,M,L,I"]
[1343,"   T",-0.604,null,9,"-0.604,-0.604",null,null,"    9,9",null,null,"  b","       s"," 149/150","T,V,A"]
[1344,"   E",0.358,null,3," 0.358, 0.358",null,null,"    3,3",null,null,"  e","        "," 149/150","R,G,E,Q,N,K,S,D"]
[1345,"   K",0.216,null,4," 0.216, 0.216",null,null,"    4,4",null,null,"  e","        "," 148/150","K,V,N,R,L,E"]
[1346,"   F",-0.369,null,7,"-0.369,-0.369",null,null,"    7,7",null,null,"  b","        "," 148/150","F,V,T,I,L"]
[1347,"   F",-0.514,null,8,"-0.514,-0.514",null,null,"    8,8",null,null,"  b","        "," 148/150","L,I,Y,F"]
[1348,"   H",0.731,null,1," 0.731, 0.731",null,null,"    1,1",null,null,"  e","        "," 148/150","S,V,C,D,L,H,X,N,K,A,T,R,G,Q,E"]
[1349,"   A",-0.036,null,5,"-0.036,-0.036",null,null,"    5,5",null,null,"  b","        "," 149/150","L,C,S,V,R,G,E,K,A"]
[1350,"   I",-0.625,null,9,"-0.625,-0.625",null,null,"    9,9",null,null,"  b","       s"," 149/150","V,L,I"]
[1351,"   I",0.097,null,4," 0.097, 0.097",null,null,"    4,4",null,null,"  b","        "," 149/150","I,L,C,T,V"]
[1352,"   S",0.593,null,1," 0.593, 0.593",null,null,"    1,1",null,null,"  e","        "," 149/150","K,N,A,T,G,E,Q,C,S,I,H,L"]
[1353,"   S",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 149/150","C,A,S"]
[1354,"   S",-0.118,null,6,"-0.118,-0.118",null,null,"    6,6",null,null,"  b","        "," 149/150","G,V,A,S,T,F"]
[1355,"   S",0.439,null,2," 0.439, 0.439",null,null,"    2,2",null,null,"  e","        "," 149/150","T,N,A,Q,E,G,S,D,P,L"]
[1356,"   E",1.29,null,1," 1.290, 1.290",null,null,"    1,1",null,null,"  e","        "," 149/150","I,M,D,V,S,R,Q,E,A,K,T"]
[1357,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","F"]
[1358,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 149/150","P"]
[1359,"   P",1.797,null,1," 1.797, 1.797",null,null,"    1,1",null,null,"  e","        "," 149/150","R,Q,K,A,T,L,P,I,V,S,F"]
[1360,"   Q",-0.58,null,9,"-0.580,-0.580",null,null,"    9,9",null,null,"  e","       f"," 149/150","Q,R,K"]
[1361,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","L"]
[1362,"   R",-0.538,null,9,"-0.538,-0.538",null,null,"    9,9",null,null,"  e","       f"," 149/150","K,R"]
[1363,"   S",-0.372,null,7,"-0.372,-0.372",null,null,"    7,7",null,null,"  e","        "," 149/150","T,Q,G,R,C,V,S,L"]
[1364,"   V",-0.56,null,9,"-0.560,-0.560",null,null,"    9,9",null,null,"  e","       f"," 149/150","V,I,M,L"]
[1365,"   C",-0.585,null,9,"-0.585,-0.585",null,null,"    9,9",null,null,"  b","       s"," 149/150","L,S,C"]
[1366,"   H",-0.488,null,8,"-0.488,-0.488",null,null,"    8,8",null,null,"  e","       f"," 149/150","N,H,R"]
[1367,"   C",-0.588,null,9,"-0.588,-0.588",null,null,"    9,9",null,null,"  b","       s"," 149/150","C,T,V"]
[1368,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","L"]
[1369,"   Y",-0.017,null,5,"-0.017,-0.017",null,null,"    5,5",null,null,"  b","        "," 149/150","K,N,R,Y,S,F,L,H"]
[1370,"   Q",-0.553,null,9,"-0.553,-0.553",null,null,"    9,9",null,null,"  e","       f"," 149/150","E,Q,Y,K"]
[1371,"   V",-0.552,null,9,"-0.552,-0.552",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,I,T,V"]
[1372,"   V",-0.599,null,9,"-0.599,-0.599",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,I,L"]
[1373,"   S",-0.237,null,7,"-0.237,-0.237",null,null,"    7,7",null,null,"  e","        "," 150/150","H,I,C,S,G,T,N,A"]
[1374,"   Q",-0.44,null,8,"-0.440,-0.440",null,null,"    8,8",null,null,"  e","       f"," 150/150","A,K,Q,R,L,H"]
[1375,"   R",-0.636,null,9,"-0.636,-0.636",null,null,"    9,9",null,null,"  e","       f"," 150/150","Y,R"]
[1376,"   F",-0.578,null,9,"-0.578,-0.578",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,F,V"]
[1377,"   P",-0.162,null,6,"-0.162,-0.162",null,null,"    6,6",null,null,"  e","        "," 150/150","G,Q,P,V,N,A,S"]
[1378,"   Q",-0.35,null,7,"-0.350,-0.350",null,null,"    7,7",null,null,"  e","        "," 150/150","T,K,N,Q,P,L,M"]
[1379,"   N",0.112,null,4," 0.112, 0.112",null,null,"    4,4",null,null,"  e","        "," 150/150","A,N,T,E,Q,D,S,I,H,L"]
[1380,"   S",-0.402,null,8,"-0.402,-0.402",null,null,"    8,8",null,null,"  e","       f"," 150/150","A,N,S,D,E,G"]
[1381,"   I",-0.383,null,8,"-0.383,-0.383",null,null,"    8,8",null,null,"  b","        "," 150/150","V,M,L,I"]
[1382,"   G",-0.155,null,6,"-0.155,-0.155",null,null,"    6,6",null,null,"  e","        "," 150/150","N,T,G,E,V,S,L,I"]
[1383,"   A",-0.61,null,9,"-0.610,-0.610",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,A"]
[1384,"   V",-0.587,null,9,"-0.587,-0.587",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,I,V"]
[1385,"   G",-0.515,null,8,"-0.515,-0.515",null,null,"    8,8",null,null,"  b","        "," 150/150","G,E,S"]
[1386,"   S",-0.619,null,9,"-0.619,-0.619",null,null,"    9,9",null,null,"  b","       s"," 150/150","T,S,M"]
[1387,"   A",-0.479,null,8,"-0.479,-0.479",null,null,"    8,8",null,null,"  b","        "," 150/150","T,V,A,L,M,I"]
[1388,"   M",-0.392,null,8,"-0.392,-0.392",null,null,"    8,8",null,null,"  b","        "," 150/150","F,V,I,L,M"]
[1389,"   F",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,F"]
[1390,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1391,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","R"]
[1392,"   F",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,Y"]
[1393,"   I",-0.559,null,9,"-0.559,-0.559",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,F,V"]
[1394,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","N"]
[1395,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","P"]
[1396,"   A",-0.647,null,9,"-0.647,-0.647",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,V"]
[1397,"   I",-0.564,null,9,"-0.564,-0.564",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,V"]
[1398,"   V",-0.654,null,9,"-0.654,-0.654",null,null,"    9,9",null,null,"  b","       s"," 150/150","T,V"]
[1399,"   S",-0.596,null,9,"-0.596,-0.596",null,null,"    9,9",null,null,"  b","       s"," 150/150","S,A,T"]
[1400,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","P"]
[1401,"   Y",-0.122,null,6,"-0.122,-0.122",null,null,"    6,6",null,null,"  e","        "," 150/150","K,T,C,F,Q,Y,H"]
[1402,"   E",-0.635,null,9,"-0.635,-0.635",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,A"]
[1403,"   A",-0.136,null,6,"-0.136,-0.136",null,null,"    6,6",null,null,"  b","        "," 150/150","A,T,Y,Q,S,H,L,M"]
[1404,"   G",-0.521,null,8,"-0.521,-0.521",null,null,"    8,8",null,null,"  e","       f"," 150/150","G,N,S"]
[1405,"   I",-0.592,null,9,"-0.592,-0.592",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,L,I"]
[1406,"   L",-0.17,null,6,"-0.170,-0.170",null,null,"    6,6",null,null,"  b","        "," 150/150","T,V,F,C,L,I"]
[1407,"   D",0.776,null,1," 0.776, 0.776",null,null,"    1,1",null,null,"  e","        "," 150/150","N,A,T,G,E,S,C,D,I,H"]
[1408,"   K",0.506,null,2," 0.506, 0.506",null,null,"    2,2",null,null,"  e","        "," 150/150","M,F,V,Q,E,R,T,N,K"]
[1409,"   K",0.422,null,2," 0.422, 0.422",null,null,"    2,2",null,null,"  e","        "," 150/150","S,V,P,I,K,A,T,E,Q,Y"]
[1410,"   P",-0.249,null,7,"-0.249,-0.249",null,null,"    7,7",null,null,"  e","        "," 150/150","V,T,I,P"]
[1411,"   P",0.568,null,1," 0.568, 0.568",null,null,"    1,1",null,null,"  e","        "," 150/150","H,L,P,A,N,S,T"]
[1412,"   P",4.074,null,1," 4.074, 4.074",null,null,"    1,1",null,null,"  e","        "," 150/150","T,A,N,Y,E,Q,S,V,H,P,L"]
[1413,"   R",1.158,null,1," 1.158, 1.158",null,null,"    1,1",null,null,"  e","        "," 150/150","T,A,N,K,E,Q,R,D,S,H,I,P"]
[1414,"   I",0.347,null,3," 0.347, 0.347",null,null,"    3,3",null,null,"  b","        "," 150/150","L,M,I,T,V,A,F"]
[1415,"   E",-0.457,null,8,"-0.457,-0.457",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,E,G,R,K"]
[1416,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","R"]
[1417,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","G"]
[1418,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1419,"   K",-0.499,null,8,"-0.499,-0.499",null,null,"    8,8",null,null,"  e","       f"," 150/150","I,M,K,T"]
[1420,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,F"]
[1421,"   M",-0.331,null,7,"-0.331,-0.331",null,null,"    7,7",null,null,"  b","        "," 150/150","V,T,I,M,L"]
[1422,"   S",-0.623,null,9,"-0.623,-0.623",null,null,"    9,9",null,null,"  b","       s"," 150/150","G,C,S"]
[1423,"   K",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","K"]
[1424,"   I",-0.489,null,8,"-0.489,-0.489",null,null,"    8,8",null,null,"  b","        "," 150/150","L,M,I,V,T"]
[1425,"   L",-0.484,null,8,"-0.484,-0.484",null,null,"    8,8",null,null,"  b","        "," 150/150","M,L,Q"]
[1426,"   Q",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q"]
[1427,"   S",-0.578,null,9,"-0.578,-0.578",null,null,"    9,9",null,null,"  e","       f"," 150/150","N,S,Q"]
[1428,"   I",-0.625,null,9,"-0.625,-0.625",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,I,V"]
[1429,"   A",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","A"]
[1430,"   N",-0.65,null,9,"-0.650,-0.650",null,null,"    9,9",null,null,"  e","       f"," 150/150","G,N"]
[1431,"   H",-0.487,null,8,"-0.487,-0.487",null,null,"    8,8",null,null,"  e","       f"," 150/150","N,Y,H,Q"]
[1432,"   V",-0.475,null,8,"-0.475,-0.475",null,null,"    8,8",null,null,"  b","        "," 150/150","T,V,I,L"]
[1433,"   L",-0.355,null,7,"-0.355,-0.355",null,null,"    7,7",null,null,"  e","        "," 150/150","T,V,Q,E,L,I"]
[1434,"   F",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,S"]
[1435,"   T",-0.542,null,9,"-0.542,-0.542",null,null,"    9,9",null,null,"  e","       f"," 149/150","S,T,L,M"]
[1436,"   K",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","K"]
[1437,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","E"]
[1438,"   E",-0.349,null,7,"-0.349,-0.349",null,null,"    7,7",null,null,"  e","        "," 150/150","V,S,I,P,L,N,K,E,Q"]
[1439,"   H",-0.606,null,9,"-0.606,-0.606",null,null,"    9,9",null,null,"  e","       f"," 150/150","Y,H,C"]
[1440,"   M",-0.658,null,9,"-0.658,-0.658",null,null,"    9,9",null,null,"  b","       s"," 150/150","M,L"]
[1441,"   R",0.203,null,4," 0.203, 0.203",null,null,"    4,4",null,null,"  e","        "," 150/150","I,P,L,M,V,E,Q,R,K"]
[1442,"   P",1.06,null,1," 1.060, 1.060",null,null,"    1,1",null,null,"  e","        "," 150/150","I,H,P,C,S,V,Y,N,A,T"]
[1443,"   F",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 150/150","C,F"]
[1444,"   N",-0.65,null,9,"-0.650,-0.650",null,null,"    9,9",null,null,"  e","       f"," 150/150","N,D"]
[1445,"   D",0.301,null,3," 0.301, 0.301",null,null,"    3,3",null,null,"  e","        "," 150/150","H,D,S,R,G,E,A,K,N"]
[1446,"   F",-0.466,null,8,"-0.466,-0.466",null,null,"    8,8",null,null,"  b","        "," 150/150","F,V,Y,L"]
[1447,"   V",-0.36,null,7,"-0.360,-0.360",null,null,"    7,7",null,null,"  b","        "," 150/150","V,I,L"]
[1448,"   K",-0.302,null,7,"-0.302,-0.302",null,null,"    7,7",null,null,"  e","        "," 150/150","T,K,S,Q,R"]
[1449,"   S",0.797,null,1," 0.797, 0.797",null,null,"    1,1",null,null,"  b","        "," 150/150","T,K,N,A,Q,E,R,D,V,S,I,L"]
[1450,"   N",-0.293,null,7,"-0.293,-0.293",null,null,"    7,7",null,null,"  e","        "," 150/150","N,K,Y,H,R"]
[1451,"   F",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,A"]
[1452,"   D",-0.251,null,7,"-0.251,-0.251",null,null,"    7,7",null,null,"  e","        "," 150/150","E,Q,G,D"]
[1453,"   A",0.969,null,1," 0.969, 0.969",null,null,"    1,1",null,null,"  e","        "," 150/150","V,S,D,M,L,P,I,H,K,N,A,T,R,G,Q"]
[1454,"   A",-0.219,null,6,"-0.219,-0.219",null,null,"    6,6",null,null,"  b","        "," 150/150","N,A,T,C,G"]
[1455,"   R",-0.474,null,8,"-0.474,-0.474",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,R,I,K"]
[1456,"   R",-0.079,null,6,"-0.079,-0.079",null,null,"    6,6",null,null,"  e","        "," 150/150","D,K,H,E,Q,R"]
[1457,"   F",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,W"]
[1458,"   F",-0.461,null,8,"-0.461,-0.461",null,null,"    8,8",null,null,"  b","        "," 150/150","I,F,V"]
[1459,"   L",0.267,null,3," 0.267, 0.267",null,null,"    3,3",null,null,"  b","        "," 150/150","I,M,L,F,S,V,Y,R,Q,E,K,N,T"]
[1460,"   D",-0.158,null,6,"-0.158,-0.158",null,null,"    6,6",null,null,"  e","        "," 150/150","T,K,N,A,E,Q,R,V,S,D"]
[1461,"   I",-0.624,null,9,"-0.624,-0.624",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,C,V"]
[1462,"   A",-0.39,null,8,"-0.390,-0.390",null,null,"    8,8",null,null,"  b","        "," 150/150","T,S,A,G,I"]
[1463,"   S",-0.402,null,8,"-0.402,-0.402",null,null,"    8,8",null,null,"  e","       f"," 150/150","E,G,N,A,L,M,V,S"]
[1464,"   D",-0.161,null,6,"-0.161,-0.161",null,null,"    6,6",null,null,"  e","        "," 150/150","T,N,K,A,D,E,G"]
[1465,"   C",-0.091,null,6,"-0.091,-0.091",null,null,"    6,6",null,null,"  b","        "," 150/150","S,C,F,L,G,P,I"]
[1466,"   P",-0.148,null,6,"-0.148,-0.148",null,null,"    6,6",null,null,"  e","        "," 150/150","D,H,E,P,G,R"]
[1467,"   T",0.238,null,3," 0.238, 0.238",null,null,"    3,3",null,null,"  e","        "," 150/150","T,K,A,S,V,F,C,P,I"]
[1468,"   S",0.882,null,1," 0.882, 0.882",null,null,"    1,1",null,null,"  e","        "," 150/150","N,A,K,T,G,Q,E,V,S,D,M,L,P,I"]
[1469,"   D",-0.072,null,5,"-0.072,-0.072",null,null,"    5,5",null,null,"  e","        "," 150/150","E,G,D"]
[1470,"   A",0.208,null,4," 0.208, 0.208",null,null,"    4,4",null,null,"  e","        "," 150/150","Q,E,G,T,A,N,H,S,V,C"]
[1471,"   V",0.904,null,1," 0.904, 0.904",null,null,"    1,1",null,null,"  e","        "," 150/150","L,I,S,V,D,G,E,N,A,T"]
[1472,"   N",0.09,null,4," 0.090, 0.090",null,null,"    4,4",null,null,"  e","        "," 150/150","T,A,N,Q,G,Y,S,P,H"]
[1473,"   H",-0.389,null,8,"-0.389,-0.389",null,null,"    8,8",null,null,"  e","       f"," 150/150","Y,H,N,S,A,T"]
[1474,"   S",-0.086,null,6,"-0.086,-0.086",null,null,"    6,6",null,null,"  b","        "," 150/150","T,N,A,S,C,P,Y"]
[1475,"   L",-0.138,null,6,"-0.138,-0.138",null,null,"    6,6",null,null,"  b","        "," 150/150","I,M,L,P,V,Y,R,K,N"]
[1476,"   S",-0.564,null,9,"-0.564,-0.564",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,S,T,P"]
[1477,"   F",-0.522,null,8,"-0.522,-0.522",null,null,"    8,8",null,null,"  b","        "," 150/150","Y,P,F"]
[1478,"   I",-0.46,null,8,"-0.460,-0.460",null,null,"    8,8",null,null,"  b","        "," 150/150","V,I,L,M"]
[1479,"   S",-0.595,null,9,"-0.595,-0.595",null,null,"    9,9",null,null,"  b","       s"," 150/150","S,N,T"]
[1480,"   D",-0.637,null,9,"-0.637,-0.637",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,D"]
[1481,"   G",-0.277,null,7,"-0.277,-0.277",null,null,"    7,7",null,null,"  b","        "," 150/150","G,T,S,A,D"]
[1482,"   N",-0.514,null,8,"-0.514,-0.514",null,null,"    8,8",null,null,"  e","       f"," 150/150","H,L,P,N,S"]
[1483,"   V",-0.448,null,8,"-0.448,-0.448",null,null,"    8,8",null,null,"  b","        "," 150/150","F,V,T,I,L"]
[1484,"   L",-0.013,null,5,"-0.013,-0.013",null,null,"    5,5",null,null,"  b","        "," 150/150","H,Y,L,F,C,V"]
[1485,"   A",-0.439,null,8,"-0.439,-0.439",null,null,"    8,8",null,null,"  b","        "," 150/150","L,T,V,A,S"]
[1486,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,V"]
[1487,"   H",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","H"]
[1488,"   R",-0.638,null,9,"-0.638,-0.638",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R"]
[1489,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1490,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1491,"   W",-0.591,null,9,"-0.591,-0.591",null,null,"    9,9",null,null,"  e","       f"," 150/150","W,F"]
[1492,"   N",-0.343,null,7,"-0.343,-0.343",null,null,"    7,7",null,null,"  e","        "," 150/150","D,S,N,T,I,M,Q"]
[1493,"   N",-0.541,null,9,"-0.541,-0.541",null,null,"    9,9",null,null,"  e","       f"," 150/150","Y,H,N"]
[1494,"   Q",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q"]
[1495,"   E",-0.528,null,8,"-0.528,-0.528",null,null,"    8,8",null,null,"  e","       f"," 150/150","E,D,V,S"]
[1496,"   K",-0.045,null,5,"-0.045,-0.045",null,null,"    5,5",null,null,"  e","        "," 150/150","R,K"]
[1497,"   I",-0.594,null,9,"-0.594,-0.594",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,M"]
[1498,"   G",-0.601,null,9,"-0.601,-0.601",null,null,"    9,9",null,null,"  b","       s"," 150/150","G,R"]
[1499,"   Q",-0.426,null,8,"-0.426,-0.426",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,E,T,A,N,D"]
[1500,"   Y",-0.507,null,8,"-0.507,-0.507",null,null,"    8,8",null,null,"  b","        "," 150/150","Y,F"]
[1501,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,L"]
[1502,"   S",-0.563,null,9,"-0.563,-0.563",null,null,"    9,9",null,null,"  e","       f"," 150/150","A,S,T"]
[1503,"   S",-0.595,null,9,"-0.595,-0.595",null,null,"    9,9",null,null,"  e","       f"," 150/150","T,S,C"]
[1504,"   N",-0.507,null,8,"-0.507,-0.507",null,null,"    8,8",null,null,"  e","       f"," 150/150","N,K,S,I,M"]
[1505,"   R",-0.589,null,9,"-0.589,-0.589",null,null,"    9,9",null,null,"  e","       f"," 150/150","S,R"]
[1506,"   D",-0.586,null,9,"-0.586,-0.586",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,S,D"]
[1507,"   H",-0.386,null,8,"-0.386,-0.386",null,null,"    8,8",null,null,"  e","       f"," 150/150","T,N,F,Q,H,W,Y"]
[1508,"   K",-0.489,null,8,"-0.489,-0.489",null,null,"    8,8",null,null,"  e","       f"," 150/150","R,K,D"]
[1509,"   A",-0.335,null,7,"-0.335,-0.335",null,null,"    7,7",null,null,"  e","        "," 150/150","D,S,A,T,H,R,Q"]
[1510,"   V",-0.507,null,8,"-0.507,-0.507",null,null,"    8,8",null,null,"  e","       f"," 150/150","V,F,L,M"]
[1511,"   G",-0.603,null,9,"-0.603,-0.603",null,null,"    9,9",null,null,"  e","       f"," 150/150","G,A"]
[1512,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","R"]
[1513,"   R",-0.588,null,9,"-0.588,-0.588",null,null,"    9,9",null,null,"  e","       f"," 150/150","T,Q,R"]
[1514,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 149/150","P"]
[1515,"   F",-0.573,null,9,"-0.573,-0.573",null,null,"    9,9",null,null,"  b","       s"," 149/150","F,V,Y"]
[1516,"   D",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  e","       f"," 149/150","D,E"]
[1517,"   K",-0.64,null,9,"-0.640,-0.640",null,null,"    9,9",null,null,"  e","       f"," 149/150","R,K"]
[1518,"   M",-0.516,null,8,"-0.516,-0.516",null,null,"    8,8",null,null,"  b","        "," 150/150","L,M"]
[1519,"   A",-0.511,null,8,"-0.511,-0.511",null,null,"    8,8",null,null,"  b","        "," 150/150","S,V,A,I"]
[1520,"   T",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","T"]
[1521,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,V"]
[1522,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1523,"   A",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","A"]
[1524,"   Y",-0.46,null,8,"-0.460,-0.460",null,null,"    8,8",null,null,"  e","       f"," 150/150","Y,H,Q"]
[1525,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,I"]
[1526,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","G"]
[1527,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","P"]
[1528,"   P",-0.586,null,9,"-0.586,-0.586",null,null,"    9,9",null,null,"  e","       f"," 150/150","P,A"]
[1529,"   E",-0.455,null,8,"-0.455,-0.455",null,null,"    8,8",null,null,"  e","       f"," 150/150","G,E,K,N,D"]
[1530,"   H",-0.521,null,8,"-0.521,-0.521",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,G,H,Y,N"]
[1531,"   K",-0.407,null,8,"-0.407,-0.407",null,null,"    8,8",null,null,"  e","       f"," 150/150","S,K,Q,R"]
[1532,"   P",0.274,null,3," 0.274, 0.274",null,null,"    3,3",null,null,"  e","        "," 150/150","T,K,S,A,P,Q,R"]
[1533,"   V",0.043,null,5," 0.043, 0.043",null,null,"    5,5",null,null,"  e","        "," 150/150","F,V,N,I,M,G,L"]
[1534,"   A",-0.279,null,7,"-0.279,-0.279",null,null,"    7,7",null,null,"  b","        ","  53/150","A,H"]
[1535,"   D",-0.174,null,6,"-0.174,-0.174",null,null,"    6,6",null,null,"  e","        "," 147/150","Y,E,F,D,S,T"]
[1536,"   T",-0.48,null,8,"-0.480,-0.480",null,null,"    8,8",null,null,"  e","       f"," 147/150","C,D,S,K,T"]
[1537,"   H",-0.14,null,6,"-0.140,-0.140",null,null,"    6,6",null,null,"  e","        "," 150/150","S,H,R,M,Q,E"]
[1538,"   W",-0.495,null,8,"-0.495,-0.495",null,null,"    8,8",null,null,"  b","        "," 150/150","F,W,R"]
[1539,"   S",-0.235,null,7,"-0.235,-0.235",null,null,"    7,7",null,null,"  b","        "," 148/150","N,A,S,T,R,G,I"]
[1540,"   S",-0.336,null,7,"-0.336,-0.336",null,null,"    7,7",null,null,"  b","        "," 148/150","G,Y,A,N,S,T"]
[1541,"   L",-0.271,null,7,"-0.271,-0.271",null,null,"    7,7",null,null,"  b","        "," 148/150","S,V,K,I,M,L"]
[1542,"   N",-0.431,null,8,"-0.431,-0.431",null,null,"    8,8",null,null,"  e","       f"," 148/150","N,D,E,P"]
[1543,"   L",-0.38,null,7,"-0.380,-0.380",null,null,"    7,7",null,null,"  b","        "," 150/150","I,Q,M,L"]
[1544,"   T",-0.429,null,8,"-0.429,-0.429",null,null,"    8,8",null,null,"  b","        "," 150/150","P,C,D,N,S,T"]
[1545,"   S",-0.561,null,9,"-0.561,-0.561",null,null,"    9,9",null,null,"  e","       f"," 150/150","S,P,G"]
[1546,"   S",-0.181,null,6,"-0.181,-0.181",null,null,"    6,6",null,null,"  e","        "," 150/150","S,A,V,N,T"]
[1547,"   K",-0.211,null,6,"-0.211,-0.211",null,null,"    6,6",null,null,"  e","        "," 150/150","Y,H,R,C,N,S,K"]
[1548,"   F",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,L"]
[1549,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","E"]
[1550,"   E",-0.268,null,7,"-0.268,-0.268",null,null,"    7,7",null,null,"  e","        "," 150/150","D,E"]
[1551,"   F",0.196,null,4," 0.196, 0.196",null,null,"    4,4",null,null,"  b","        "," 150/150","F,C,V,I,L,M"]
[1552,"   M",-0.602,null,9,"-0.602,-0.602",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,M,I,A"]
[1553,"   T",-0.083,null,6,"-0.083,-0.083",null,null,"    6,6",null,null,"  b","        "," 150/150","S,V,M,I,T,K,N,A,R"]
[1554,"   R",-0.398,null,8,"-0.398,-0.398",null,null,"    8,8",null,null,"  e","       f"," 150/150","R,G,Q,K"]
[1555,"   H",-0.241,null,7,"-0.241,-0.241",null,null,"    7,7",null,null,"  e","        "," 149/150","S,H,Y,Q,R,L"]
[1556,"   Q",-0.437,null,8,"-0.437,-0.437",null,null,"    8,8",null,null,"  e","       f"," 149/150","A,S,N,Q,I"]
[1557,"   V",-0.231,null,7,"-0.231,-0.231",null,null,"    7,7",null,null,"  e","        "," 150/150","M,L,H,I,V,F,E,A"]
[1558,"   H",-0.052,null,5,"-0.052,-0.052",null,null,"    5,5",null,null,"  e","        "," 150/150","R,Q,E,A,T,H,L,F,D"]
[1559,"   E",-0.125,null,6,"-0.125,-0.125",null,null,"    6,6",null,null,"  e","        "," 150/150","D,V,S,K,N,E,Q"]
[1560,"   K",-0.188,null,6,"-0.188,-0.188",null,null,"    6,6",null,null,"  e","        "," 150/150","S,D,L,T,N,K,E,R"]
[1561,"   E",-0.093,null,6,"-0.093,-0.093",null,null,"    6,6",null,null,"  e","        "," 150/150","D,I,E"]
[1562,"   E",-0.276,null,7,"-0.276,-0.276",null,null,"    7,7",null,null,"  e","        "," 150/150","E,D,K,N"]
[1563,"   F",-0.418,null,8,"-0.418,-0.418",null,null,"    8,8",null,null,"  b","        "," 150/150","F,L,Y"]
[1564,"   K",-0.553,null,9,"-0.553,-0.553",null,null,"    9,9",null,null,"  e","       f"," 150/150","N,K,I,Q"]
[1565,"   A",-0.155,null,6,"-0.155,-0.155",null,null,"    6,6",null,null,"  e","        "," 150/150","T,N,A,Q,R,C,S,H"]
[1566,"   L",-0.237,null,7,"-0.237,-0.237",null,null,"    7,7",null,null,"  b","        "," 150/150","V,F,L,M,I"]
[1567,"   K",-0.644,null,9,"-0.644,-0.644",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,Q"]
[1568,"   T",-0.081,null,6,"-0.081,-0.081",null,null,"    6,6",null,null,"  e","        "," 150/150","E,T,A,S,N,C"]
[1569,"   L",-0.349,null,7,"-0.349,-0.349",null,null,"    7,7",null,null,"  b","        "," 150/150","M,L,N,V,T"]
[1570,"   S",-0.466,null,8,"-0.466,-0.466",null,null,"    8,8",null,null,"  e","       f"," 150/150","N,S,T,H,L,M"]
[1571,"   I",-0.479,null,8,"-0.479,-0.479",null,null,"    8,8",null,null,"  b","        "," 150/150","I,L,V,A"]
[1572,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1573,"   Y",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,K"]
[1574,"   Q",-0.618,null,9,"-0.618,-0.618",null,null,"    9,9",null,null,"  e","       f"," 150/150","H,M,Q"]
[1575,"   A",-0.473,null,8,"-0.473,-0.473",null,null,"    8,8",null,null,"  e","       f"," 150/150","G,E,C,D,A,S"]
[1576,"   G",-0.517,null,8,"-0.517,-0.517",null,null,"    8,8",null,null,"  b","        "," 150/150","E,G"]
[1577,"   T",-0.408,null,8,"-0.408,-0.408",null,null,"    8,8",null,null,"  e","       f"," 150/150","Y,I,F,T,N,S,K"]
[1578,"   S",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  e","       f"," 150/150","T,S,N"]
[1579,"   K",-0.039,null,5,"-0.039,-0.039",null,null,"    5,5",null,null,"  e","        "," 150/150","R,T,K"]
[1580,"   A",0.994,null,1," 0.994, 0.994",null,null,"    1,1",null,null,"  e","        "," 150/150","L,I,V,S,C,D,R,G,Q,E,N,K,A,T"]
[1581,"   G",-0.35,null,7,"-0.350,-0.350",null,null,"    7,7",null,null,"  e","        "," 150/150","N,S,D,G"]
[1582,"   N",0.587,null,1," 0.587, 0.587",null,null,"    1,1",null,null,"  e","        "," 150/150","L,H,Y,N,S,F"]
[1583,"   P",-0.584,null,9,"-0.584,-0.584",null,null,"    9,9",null,null,"  e","       f"," 150/150","P,M"]
[1584,"   I",-0.557,null,9,"-0.557,-0.557",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,I"]
[1585,"   F",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,F"]
[1586,"   Y",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,I"]
[1587,"   Y",-0.437,null,8,"-0.437,-0.437",null,null,"    8,8",null,null,"  b","        "," 150/150","Y,F,C"]
[1588,"   V",-0.399,null,8,"-0.399,-0.399",null,null,"    8,8",null,null,"  b","        "," 150/150","V,I"]
[1589,"   A",-0.404,null,8,"-0.404,-0.404",null,null,"    8,8",null,null,"  b","        "," 150/150","T,A,S,F,G"]
[1590,"   R",-0.585,null,9,"-0.585,-0.585",null,null,"    9,9",null,null,"  e","       f"," 150/150","R,N,V"]
[1591,"   R",-0.59,null,9,"-0.590,-0.590",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q,R,K"]
[1592,"   F",-0.15,null,6,"-0.150,-0.150",null,null,"    6,6",null,null,"  b","        "," 150/150","F,H,Y"]
[1593,"   K",-0.554,null,9,"-0.554,-0.554",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R"]
[1594,"   T",-0.11,null,6,"-0.110,-0.110",null,null,"    6,6",null,null,"  e","        "," 150/150","G,Y,T,P,L,M,H,I,V,S,F,C"]
[1595,"   G",0.468,null,2," 0.468, 0.468",null,null,"    2,2",null,null,"  e","        "," 150/150","T,A,S,N,D,R,G"]
[1596,"   Q",-0.29,null,7,"-0.290,-0.290",null,null,"    7,7",null,null,"  e","        "," 150/150","Q,E,D"]
[1597,"   I",-0.304,null,7,"-0.304,-0.304",null,null,"    7,7",null,null,"  e","        "," 150/150","M,I,V,S,T"]
[1598,"   N",-0.454,null,8,"-0.454,-0.454",null,null,"    8,8",null,null,"  e","       f"," 150/150","E,D,T,N,S"]
[1599,"   G",0.282,null,3," 0.282, 0.282",null,null,"    3,3",null,null,"  b","        "," 150/150","F,D,A,V,S,Y,G"]
[1600,"   D",-0.392,null,8,"-0.392,-0.392",null,null,"    8,8",null,null,"  e","       f"," 150/150","E,P,D,N"]
[1601,"   L",-0.179,null,6,"-0.179,-0.179",null,null,"    6,6",null,null,"  b","        "," 150/150","F,C,M,L,Q,I"]
[1602,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L"]
[1603,"   I",-0.355,null,7,"-0.355,-0.355",null,null,"    7,7",null,null,"  b","        "," 150/150","V,M,L,I"]
[1604,"   Y",-0.566,null,9,"-0.566,-0.566",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,F,C"]
[1605,"   H",-0.647,null,9,"-0.647,-0.647",null,null,"    9,9",null,null,"  b","       s"," 150/150","H,L"]
[1606,"   V",-0.589,null,9,"-0.589,-0.589",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,A,V"]
[1607,"   L",-0.313,null,7,"-0.313,-0.313",null,null,"    7,7",null,null,"  b","        "," 150/150","M,L,I,Y,V,S"]
[1608,"   L",-0.471,null,8,"-0.471,-0.471",null,null,"    8,8",null,null,"  b","        "," 150/150","I,M,L,Q"]
[1609,"   T",-0.583,null,9,"-0.583,-0.583",null,null,"    9,9",null,null,"  e","       f"," 150/150","T,S,V"]
[1610,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1611,"   K",-0.542,null,9,"-0.542,-0.542",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,K,R,E"]
[1612,"   P",0.047,null,5," 0.047, 0.047",null,null,"    5,5",null,null,"  e","        "," 150/150","A,S,Q,P"]
[1613,"   Y",0.004,null,5," 0.004, 0.004",null,null,"    5,5",null,null,"  e","        "," 150/150","Y,H,L,F,C,K"]
[1614,"   Y",0.106,null,4," 0.106, 0.106",null,null,"    4,4",null,null,"  b","        "," 150/150","H,I,D,C,F,S,V,W,Y,R"]
[1615,"   A",0.084,null,4," 0.084, 0.084",null,null,"    4,4",null,null,"  e","        "," 150/150","E,Q,R,Y,A,N,K,H,S,D"]
[1616,"   K",-0.125,null,6,"-0.125,-0.125",null,null,"    6,6",null,null,"  e","        "," 150/150","R,Q,E,A,N,K,T,S"]
[1617,"   P",0.221,null,4," 0.221, 0.221",null,null,"    4,4",null,null,"  e","        "," 150/150","H,G,P,Q,A,S,T"]
[1618,"   Y",-0.46,null,8,"-0.460,-0.460",null,null,"    8,8",null,null,"  b","        "," 150/150","Y,I,W,F"]
[1619,"   E",-0.428,null,8,"-0.428,-0.428",null,null,"    8,8",null,null,"  e","       f"," 150/150","D,E"]
[1620,"   I",0.278,null,3," 0.278, 0.278",null,null,"    3,3",null,null,"  b","        "," 150/150","V,L,I"]
[1621,"   V",-0.49,null,8,"-0.490,-0.490",null,null,"    8,8",null,null,"  b","        "," 150/150","V,L,I"]
[1622,"   V",0.164,null,4," 0.164, 0.164",null,null,"    4,4",null,null,"  b","        "," 150/150","I,M,L,F,V"]
[1623,"   D",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","D"]
[1624,"   L",-0.239,null,7,"-0.239,-0.239",null,null,"    7,7",null,null,"  b","        "," 150/150","L,C,F"]
[1625,"   T",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","T"]
[1626,"   H",-0.569,null,9,"-0.569,-0.569",null,null,"    9,9",null,null,"  b","       s"," 150/150","N,H,R"]
[1627,"   T",-0.258,null,7,"-0.258,-0.258",null,null,"    7,7",null,null,"  e","        "," 150/150","T,V,A,F,M"]
[1628,"   G",0.082,null,4," 0.082, 0.082",null,null,"    4,4",null,null,"  b","        "," 150/150","C,S,N,T,G,R"]
[1629,"   P",0.05,null,5," 0.050, 0.050",null,null,"    5,5",null,null,"  e","        "," 150/150","G,L,P,A,V,S,T"]
[1630,"   S",0.039,null,5," 0.039, 0.039",null,null,"    5,5",null,null,"  e","        "," 150/150","E,Y,V,S,D"]
[1631,"   N",-0.614,null,9,"-0.614,-0.614",null,null,"    9,9",null,null,"  e","       f"," 150/150","H,N,C"]
[1632,"   R",-0.589,null,9,"-0.589,-0.589",null,null,"    9,9",null,null,"  e","       f"," 149/150","R,Q,K"]
[1633,"   F",-0.579,null,9,"-0.579,-0.579",null,null,"    9,9",null,null,"  b","       s"," 149/150","Y,C,F"]
[1634,"   K",-0.32,null,7,"-0.320,-0.320",null,null,"    7,7",null,null,"  e","        "," 150/150","S,K,R"]
[1635,"   T",-0.277,null,7,"-0.277,-0.277",null,null,"    7,7",null,null,"  b","        "," 150/150","T,N,V,A,S,P"]
[1636,"   D",-0.304,null,7,"-0.304,-0.304",null,null,"    7,7",null,null,"  e","        "," 150/150","Q,E,D,S"]
[1637,"   F",0.105,null,4," 0.105, 0.105",null,null,"    4,4",null,null,"  b","        "," 150/150","V,S,T,C,F,L,Y"]
[1638,"   L",-0.631,null,9,"-0.631,-0.631",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,L"]
[1639,"   S",-0.422,null,8,"-0.422,-0.422",null,null,"    8,8",null,null,"  e","       f"," 150/150","L,G,Q,H,S,N"]
[1640,"   K",-0.55,null,9,"-0.550,-0.550",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R,G"]
[1641,"   W",-0.489,null,8,"-0.489,-0.489",null,null,"    8,8",null,null,"  b","        "," 150/150","L,G,W"]
[1642,"   F",-0.515,null,8,"-0.515,-0.515",null,null,"    8,8",null,null,"  b","        "," 149/150","L,F,A"]
[1643,"   V",0.131,null,4," 0.131, 0.131",null,null,"    4,4",null,null,"  e","        "," 150/150","F,C,V,S,H,L,N,A,T,Y,Q"]
[1644,"   V",-0.402,null,8,"-0.402,-0.402",null,null,"    8,8",null,null,"  b","        "," 150/150","I,R,M,V"]
[1645,"   F",-0.289,null,7,"-0.289,-0.289",null,null,"    7,7",null,null,"  b","        "," 150/150","I,L,M,F,V,T"]
[1646,"   P",-0.406,null,8,"-0.406,-0.406",null,null,"    8,8",null,null,"  b","        "," 150/150","T,S,P,G"]
[1647,"   G",0.716,null,1," 0.716, 0.716",null,null,"    1,1",null,null,"  e","        "," 150/150","V,D,P,T,K,A,N,Q,E,G"]
[1648,"   F",0.611,null,1," 0.611, 0.611",null,null,"    1,1",null,null,"  b","        "," 150/150","S,V,F,D,M,L,P,I,H,K,A,T,G"]
[1649,"   A",-0.184,null,6,"-0.184,-0.184",null,null,"    6,6",null,null,"  b","        "," 150/150","V,F,L,M,I,A,T,G,Y"]
[1650,"   Y",-0.085,null,6,"-0.085,-0.085",null,null,"    6,6",null,null,"  e","        "," 150/150","N,T,Y,R,Q,C,V,I,M"]
[1651,"   D",0.948,null,1," 0.948, 0.948",null,null,"    1,1",null,null,"  e","        "," 150/150","S,D,P,L,H,I,T,K,N,Q,E"]
[1652,"   N",-0.535,null,9,"-0.535,-0.535",null,null,"    9,9",null,null,"  e","       f"," 150/150","R,Y,K,N"]
[1653,"   V",-0.024,null,5,"-0.024,-0.024",null,null,"    5,5",null,null,"  b","        "," 150/150","L,I,V"]
[1654,"   S",0.578,null,1," 0.578, 0.578",null,null,"    1,1",null,null,"  b","        "," 150/150","H,I,L,M,C,F,S,V,W,Y,Q,R,T,A,N"]
[1655,"   A",-0.147,null,6,"-0.147,-0.147",null,null,"    6,6",null,null,"  b","        "," 150/150","Q,T,A,N,I,M,C,S,V"]
[1656,"   V",0.141,null,4," 0.141, 0.141",null,null,"    4,4",null,null,"  b","        "," 150/150","T,A,S,V,C,I"]
[1657,"   Y",-0.567,null,9,"-0.567,-0.567",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,F"]
[1658,"   I",-0.359,null,7,"-0.359,-0.359",null,null,"    7,7",null,null,"  b","        "," 150/150","I,L,M,V"]
[1659,"   Y",-0.626,null,9,"-0.626,-0.626",null,null,"    9,9",null,null,"  b","       s"," 150/150","C,Y"]
[1660,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","N"]
[1661,"   C",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","C"]
[1662,"   N",-0.65,null,9,"-0.650,-0.650",null,null,"    9,9",null,null,"  e","       f"," 150/150","N,S"]
[1663,"   S",-0.265,null,7,"-0.265,-0.265",null,null,"    7,7",null,null,"  e","        "," 150/150","N,S,T,G"]
[1664,"   W",-0.393,null,8,"-0.393,-0.393",null,null,"    8,8",null,null,"  e","       f"," 150/150","S,T,R,W"]
[1665,"   V",-0.45,null,8,"-0.450,-0.450",null,null,"    8,8",null,null,"  b","        "," 150/150","V,A,T,L,I"]
[1666,"   R",-0.638,null,9,"-0.638,-0.638",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R"]
[1667,"   E",-0.586,null,9,"-0.586,-0.586",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q,E,D"]
[1668,"   Y",-0.508,null,8,"-0.508,-0.508",null,null,"    8,8",null,null,"  b","        "," 150/150","Y,H,F"]
[1669,"   T",-0.378,null,7,"-0.378,-0.378",null,null,"    7,7",null,null,"  b","        "," 150/150","I,T,A,S"]
[1670,"   K",-0.643,null,9,"-0.643,-0.643",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R"]
[1671,"   Y",0.483,null,2," 0.483, 0.483",null,null,"    2,2",null,null,"  e","        "," 150/150","C,F,I,Y,L,R"]
[1672,"   H",-0.513,null,8,"-0.513,-0.513",null,null,"    8,8",null,null,"  e","       f"," 150/150","Y,H,N"]
[1673,"   E",-0.19,null,6,"-0.190,-0.190",null,null,"    6,6",null,null,"  e","        "," 150/150","N,D,E"]
[1674,"   R",-0.292,null,7,"-0.292,-0.292",null,null,"    7,7",null,null,"  e","        "," 150/150","T,N,A,E,Q,R,S,H"]
[1675,"   L",-0.343,null,7,"-0.343,-0.343",null,null,"    7,7",null,null,"  b","        "," 150/150","L,I,H,V,F"]
[1676,"   L",-0.229,null,7,"-0.229,-0.229",null,null,"    7,7",null,null,"  b","        "," 150/150","L,M,F,V"]
[1677,"   T",0.332,null,3," 0.332, 0.332",null,null,"    3,3",null,null,"  b","        "," 150/150","G,T,N,A,P,M,L,S,V"]
[1678,"   G",-0.152,null,6,"-0.152,-0.152",null,null,"    6,6",null,null,"  e","        "," 150/150","A,S,P,L,R,G"]
[1679,"   L",-0.412,null,8,"-0.412,-0.412",null,null,"    8,8",null,null,"  b","        "," 150/150","F,I,L"]
[1680,"   K",-0.502,null,8,"-0.502,-0.502",null,null,"    8,8",null,null,"  e","       f"," 150/150","K,R"]
[1681,"   G",0.283,null,3," 0.283, 0.283",null,null,"    3,3",null,null,"  e","        "," 150/150","T,A,N,S,Y,G"]
[1682,"   S",-0.231,null,7,"-0.231,-0.231",null,null,"    7,7",null,null,"  e","        "," 150/150","C,D,S,N,T,H,R"]
[1683,"   K",-0.539,null,9,"-0.539,-0.539",null,null,"    9,9",null,null,"  e","       f"," 150/150","R,H,S,K"]
[1684,"   R",-0.449,null,8,"-0.449,-0.449",null,null,"    8,8",null,null,"  e","       f"," 150/150","V,K,R,Q"]
[1685,"   L",0.03,null,5," 0.030, 0.030",null,null,"    5,5",null,null,"  b","        "," 150/150","V,M,L,I"]
[1686,"   V",1.046,null,1," 1.046, 1.046",null,null,"    1,1",null,null,"  b","        "," 150/150","A,N,K,Y,Q,R,F,V,I,M,L"]
[1687,"   F",-0.577,null,9,"-0.577,-0.577",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,F,V"]
[1688,"   I",0.146,null,4," 0.146, 0.146",null,null,"    4,4",null,null,"  b","        "," 150/150","M,L,I,V,C"]
[1689,"   D",-0.058,null,5,"-0.058,-0.058",null,null,"    5,5",null,null,"  b","        "," 150/150","E,D"]
[1690,"   C",0.767,null,1," 0.767, 0.767",null,null,"    1,1",null,null,"  b","        "," 150/150","G,Y,T,N,A,P,M,L,H,I,S,V,C"]
[1691,"   P",0.579,null,1," 0.579, 0.579",null,null,"    1,1",null,null,"  e","        "," 150/150","L,P,H,V,S,Q,A,N,T"]
[1692,"   G",1.313,null,1," 1.313, 1.313",null,null,"    1,1",null,null,"  e","        "," 150/150","I,M,C,V,S,E,Q,G,R,T,N,A"]
[1693,"   K",0.22,null,4," 0.220, 0.220",null,null,"    4,4",null,null,"  e","        "," 150/150","R,Q,K,N"]
[1694,"   L",-0.578,null,9,"-0.578,-0.578",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L,F"]
[1695,"   A",0.243,null,3," 0.243, 0.243",null,null,"    3,3",null,null,"  e","        "," 150/150","K,A,N,T,Y,G,Q,C,S,I,H"]
[1696,"   E",0.234,null,3," 0.234, 0.234",null,null,"    3,3",null,null,"  e","        "," 150/150","D,E"]
[1697,"   H",0.912,null,1," 0.912, 0.912",null,null,"    1,1",null,null,"  b","        "," 150/150","L,M,H,V,C,F,Y,A"]
[1698,"   I",-0.272,null,7,"-0.272,-0.272",null,null,"    7,7",null,null,"  b","        "," 150/150","I,V"]
[1699,"   E",0.426,null,2," 0.426, 0.426",null,null,"    2,2",null,null,"  e","        "," 150/150","T,S,A,D,E"]
[1700,"   H",2.841,null,1," 2.841, 2.841",null,null,"    1,1",null,null,"  e","        "," 150/150","P,L,M,H,I,S,V,F,Q,Y,T,N,A"]
[1701,"   E",0.289,null,3," 0.289, 0.289",null,null,"    3,3",null,null,"  e","        "," 150/150","D,S,E"]
[1702,"   Q",-0.314,null,7,"-0.314,-0.314",null,null,"    7,7",null,null,"  e","        "," 150/150","L,Q,E,H,W,K"]
[1703,"   Q",-0.544,null,9,"-0.544,-0.544",null,null,"    9,9",null,null,"  e","       f"," 150/150","S,L,Q"]
[1704,"   K",-0.275,null,7,"-0.275,-0.275",null,null,"    7,7",null,null,"  e","        "," 150/150","K,R,Q"]
[1705,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","M,L"]
[1706,"   P",-0.584,null,9,"-0.584,-0.584",null,null,"    9,9",null,null,"  e","       f"," 150/150","H,P"]
[1707,"   A",-0.342,null,7,"-0.342,-0.342",null,null,"    7,7",null,null,"  e","        "," 150/150","G,A,S,K"]
[1708,"   A",-0.222,null,6,"-0.222,-0.222",null,null,"    6,6",null,null,"  b","        "," 150/150","P,G,T,V,S,A"]
[1709,"   T",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","T"]
[1710,"   L",-0.406,null,8,"-0.406,-0.406",null,null,"    8,8",null,null,"  b","        "," 150/150","L,I,V,S"]
[1711,"   A",-0.011,null,5,"-0.011,-0.011",null,null,"    5,5",null,null,"  e","        "," 150/150","A,N,T,G,Q,S,V,I,L"]
[1712,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,I"]
[1713,"   E",-0.211,null,6,"-0.211,-0.211",null,null,"    6,6",null,null,"  e","        "," 150/150","D,E"]
[1714,"   E",-0.533,null,8,"-0.533,-0.533",null,null,"    8,8",null,null,"  e","       f"," 150/150","D,F,K,E"]
[1715,"   D",-0.637,null,9,"-0.637,-0.637",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,Y"]
[1716,"   L",-0.516,null,8,"-0.516,-0.516",null,null,"    8,8",null,null,"  b","        "," 150/150","V,L,M,I"]
[1717,"   K",-0.444,null,8,"-0.444,-0.444",null,null,"    8,8",null,null,"  e","       f"," 150/150","M,L,R,N,K"]
[1718,"   V",-0.519,null,8,"-0.519,-0.519",null,null,"    8,8",null,null,"  e","       f"," 150/150","T,K,V,L,M,I"]
[1719,"   F",-0.476,null,8,"-0.476,-0.476",null,null,"    8,8",null,null,"  b","        "," 150/150","S,F,Y"]
[1720,"   H",0.108,null,4," 0.108, 0.108",null,null,"    4,4",null,null,"  e","        "," 148/150","F,S,N,A,T,I,H"]
[1721,"   N",-0.119,null,6,"-0.119,-0.119",null,null,"    6,6",null,null,"  e","        "," 150/150","H,G,P,N,S"]
[1722,"   A",-0.412,null,8,"-0.412,-0.412",null,null,"    8,8",null,null,"  b","        "," 150/150","G,M,F,A,V"]
[1723,"   L",-0.578,null,9,"-0.578,-0.578",null,null,"    9,9",null,null,"  b","       s"," 150/150","H,L,F"]
[1724,"   K",-0.554,null,9,"-0.554,-0.554",null,null,"    9,9",null,null,"  e","       f"," 150/150","L,R,K"]
[1725,"   L",-0.395,null,8,"-0.395,-0.395",null,null,"    8,8",null,null,"  e","       f"," 150/150","L,I,Y,V"]
[1726,"   A",-0.43,null,8,"-0.430,-0.430",null,null,"    8,8",null,null,"  e","       f"," 150/150","C,S,N,A,P"]
[1727,"   H",-0.442,null,8,"-0.442,-0.442",null,null,"    8,8",null,null,"  e","       f"," 150/150","H,L,P,N,S,T"]
[1728,"   K",-0.465,null,8,"-0.465,-0.465",null,null,"    8,8",null,null,"  e","       f"," 150/150","R,A,K"]
[1729,"   D",-0.476,null,8,"-0.476,-0.476",null,null,"    8,8",null,null,"  e","       f"," 148/150","E,N,D"]
[1730,"   T",-0.401,null,8,"-0.401,-0.401",null,null,"    8,8",null,null,"  e","       f"," 150/150","I,M,L,S,T"]
[1731,"   K",-0.365,null,7,"-0.365,-0.365",null,null,"    7,7",null,null,"  e","        "," 149/150","R,N,S,K"]
[1732,"   V",-0.621,null,9,"-0.621,-0.621",null,null,"    9,9",null,null,"  b","       s"," 149/150","I,C,V"]
[1733,"   S",0.2,null,4," 0.200, 0.200",null,null,"    4,4",null,null,"  b","        "," 149/150","T,N,A,Y,C,S,I,L"]
[1734,"   I",-0.359,null,7,"-0.359,-0.359",null,null,"    7,7",null,null,"  b","        "," 150/150","L,I,V,F"]
[1735,"   K",-0.643,null,9,"-0.643,-0.643",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,Q"]
[1736,"   V",-0.524,null,8,"-0.524,-0.524",null,null,"    8,8",null,null,"  b","        "," 150/150","I,L,V"]
[1737,"   G",-0.599,null,9,"-0.599,-0.599",null,null,"    9,9",null,null,"  b","       s"," 150/150","G,C"]
[1738,"   S",-0.195,null,6,"-0.195,-0.195",null,null,"    6,6",null,null,"  e","        "," 150/150","T,S,P,L"]
[1739,"   T",-0.321,null,7,"-0.321,-0.321",null,null,"    7,7",null,null,"  e","        "," 150/150","N,S,A,T,H,Q"]
[1740,"   A",-0.531,null,8,"-0.531,-0.531",null,null,"    8,8",null,null,"  b","        "," 150/150","A,S,T"]
[1741,"   V",-0.243,null,7,"-0.243,-0.243",null,null,"    7,7",null,null,"  b","        "," 150/150","V,F,M,L,I"]
[1742,"   Q",-0.652,null,9,"-0.652,-0.652",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q,H"]
[1743,"   V",-0.272,null,7,"-0.272,-0.272",null,null,"    7,7",null,null,"  b","        "," 150/150","V,I"]
[1744,"   T",-0.617,null,9,"-0.617,-0.617",null,null,"    9,9",null,null,"  e","       f"," 150/150","M,T,C"]
[1745,"   S",-0.255,null,7,"-0.255,-0.255",null,null,"    7,7",null,null,"  e","        "," 150/150","C,T,S,A,H,Y"]
[1746,"   A",0.479,null,2," 0.479, 0.479",null,null,"    2,2",null,null,"  e","        "," 150/150","A,N,T,Y,S,V,I,M,L,P"]
[1747,"   E",-0.534,null,9,"-0.534,-0.534",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,D"]
[1748,"   R",-0.363,null,7,"-0.363,-0.363",null,null,"    7,7",null,null,"  e","        "," 150/150","K,R"]
[1749,"   T",-0.067,null,5,"-0.067,-0.067",null,null,"    5,5",null,null,"  b","        "," 150/150","V,S,C,L,H,T,A,Q,Y"]
[1750,"   K",-0.413,null,8,"-0.413,-0.413",null,null,"    8,8",null,null,"  e","       f"," 150/150","R,K"]
[1751,"   V",-0.621,null,9,"-0.621,-0.621",null,null,"    9,9",null,null,"  e","       f"," 150/150","L,I,V"]
[1752,"   L",-0.578,null,9,"-0.578,-0.578",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,I,F"]
[1753,"   G",-0.077,null,6,"-0.077,-0.077",null,null,"    6,6",null,null,"  e","        "," 150/150","W,G,N,V,A,S"]
[1754,"   Q",-0.2,null,6,"-0.200,-0.200",null,null,"    6,6",null,null,"  e","        "," 150/150","H,I,Y,Q,L,F"]
[1755,"   S",0.126,null,4," 0.126, 0.126",null,null,"    4,4",null,null,"  b","        "," 150/150","Y,W,Q,N,A,T,P,S"]
[1756,"   V",-0.465,null,8,"-0.465,-0.465",null,null,"    8,8",null,null,"  b","        "," 150/150","V,A,S,I"]
[1757,"   F",0.124,null,4," 0.124, 0.124",null,null,"    4,4",null,null,"  b","        "," 150/150","L,Y,I,A,V,T,F"]
[1758,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1759,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","N"]
[1760,"   D",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","D"]
[1761,"   I",-0.49,null,8,"-0.490,-0.490",null,null,"    8,8",null,null,"  b","        "," 150/150","I,V"]
[1762,"   Y",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,F"]
[1763,"   Y",-0.622,null,9,"-0.622,-0.622",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,L"]
[1764,"   A",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","A"]
[1765,"   S",-0.595,null,9,"-0.595,-0.595",null,null,"    9,9",null,null,"  b","       s"," 150/150","C,F,S,A"]
[1766,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","E"]
[1767,"   I",-0.595,null,9,"-0.595,-0.595",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,V"]
[1768,"   E",-0.323,null,7,"-0.323,-0.323",null,null,"    7,7",null,null,"  e","        "," 150/150","K,V,D,E,Q"]
[1769,"   E",-0.347,null,7,"-0.347,-0.347",null,null,"    7,7",null,null,"  e","        "," 150/150","G,E,V,A,F,D"]
[1770,"   I",-0.556,null,9,"-0.556,-0.556",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,A,I"]
[1771,"   C",-0.328,null,7,"-0.328,-0.328",null,null,"    7,7",null,null,"  b","        "," 150/150","A,S,T,C"]
[1772,"   L",-0.397,null,8,"-0.397,-0.397",null,null,"    8,8",null,null,"  b","        "," 150/150","V,A,P,M,L"]
[1773,"   V",-0.451,null,8,"-0.451,-0.451",null,null,"    8,8",null,null,"  b","        "," 150/150","V,I,P,E,L,M"]
[1774,"   D",-0.588,null,9,"-0.588,-0.588",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,D"]
[1775,"   E",-0.431,null,8,"-0.431,-0.431",null,null,"    8,8",null,null,"  e","       f"," 150/150","E,S,N,D"]
[1776,"   N",-0.471,null,8,"-0.471,-0.471",null,null,"    8,8",null,null,"  e","       f"," 150/150","T,S,N"]
[1777,"   Q",-0.579,null,9,"-0.579,-0.579",null,null,"    9,9",null,null,"  e","       f"," 150/150","S,L,Q"]
[1778,"   F",-0.578,null,9,"-0.578,-0.578",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,C,M"]
[1779,"   T",-0.502,null,8,"-0.502,-0.502",null,null,"    8,8",null,null,"  b","        "," 150/150","S,V,T,L"]
[1780,"   L",-0.518,null,8,"-0.518,-0.518",null,null,"    8,8",null,null,"  b","        "," 150/150","V,L,I"]
[1781,"   T",-0.399,null,8,"-0.399,-0.399",null,null,"    8,8",null,null,"  b","        "," 150/150","T,S,K,N,G,I"]
[1782,"   I",-0.541,null,9,"-0.541,-0.541",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L,M,V"]
[1783,"   A",0.028,null,5," 0.028, 0.028",null,null,"    5,5",null,null,"  b","        "," 149/150","M,L,I,S,V,A,T"]
[1784,"   N",-0.538,null,9,"-0.538,-0.538",null,null,"    9,9",null,null,"  e","       f"," 150/150","N,D,Q,I"]
[1785,"   Q",-0.479,null,8,"-0.479,-0.479",null,null,"    8,8",null,null,"  e","       f"," 150/150","V,D,G,E,Q"]
[1786,"   G",0.044,null,5," 0.044, 0.044",null,null,"    5,5",null,null,"  e","        "," 150/150","N,A,T,G,C,S,V,P"]
[1787,"   T",0.495,null,2," 0.495, 0.495",null,null,"    2,2",null,null,"  e","        "," 149/150","P,S,V,R,G,E,A,T"]
[1788,"   P",0.244,null,3," 0.244, 0.244",null,null,"    3,3",null,null,"  e","        "," 150/150","Q,P,L,G,T,N"]
[1789,"   L",-0.58,null,9,"-0.580,-0.580",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L"]
[1790,"   T",-0.377,null,7,"-0.377,-0.377",null,null,"    7,7",null,null,"  b","        "," 150/150","T,A,S,K,V,H,L"]
[1791,"   F",-0.525,null,8,"-0.525,-0.525",null,null,"    8,8",null,null,"  b","        "," 150/150","F,L"]
[1792,"   M",-0.495,null,8,"-0.495,-0.495",null,null,"    8,8",null,null,"  b","        "," 150/150","T,V,A,F,M,I"]
[1793,"   H",-0.486,null,8,"-0.486,-0.486",null,null,"    8,8",null,null,"  e","       f"," 150/150","S,Q,Y,H"]
[1794,"   Q",-0.138,null,6,"-0.138,-0.138",null,null,"    6,6",null,null,"  e","        "," 150/150","I,Q,D,A,S,N,T"]
[1795,"   E",-0.439,null,8,"-0.439,-0.439",null,null,"    8,8",null,null,"  e","       f"," 150/150","S,A,D,E"]
[1796,"   C",-0.637,null,9,"-0.637,-0.637",null,null,"    9,9",null,null,"  b","       s"," 150/150","S,C"]
[1797,"   E",-0.171,null,6,"-0.171,-0.171",null,null,"    6,6",null,null,"  e","        "," 150/150","N,D,E"]
[1798,"   A",0.208,null,4," 0.208, 0.208",null,null,"    4,4",null,null,"  e","        "," 150/150","E,Q,G,T,N,A,I,S,C"]
[1799,"   I",-0.563,null,9,"-0.563,-0.563",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L,V,T"]
[1800,"   V",-0.588,null,9,"-0.588,-0.588",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,V"]
[1801,"   Q",-0.36,null,7,"-0.360,-0.360",null,null,"    7,7",null,null,"  e","        "," 150/150","R,Q,H,A,S,N,K"]
[1802,"   S",-0.336,null,7,"-0.336,-0.336",null,null,"    7,7",null,null,"  b","        "," 150/150","D,C,N,A,S"]
[1803,"   I",-0.5,null,8,"-0.500,-0.500",null,null,"    8,8",null,null,"  b","        "," 150/150","V,I"]
[1804,"   I",-0.139,null,6,"-0.139,-0.139",null,null,"    6,6",null,null,"  b","        "," 150/150","I,L,C,V,Y,R,Q,N,A,T"]
[1805,"   H",-0.608,null,9,"-0.608,-0.608",null,null,"    9,9",null,null,"  b","       s"," 150/150","N,H,Y"]
[1806,"   I",-0.625,null,9,"-0.625,-0.625",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L,V"]
[1807,"   R",-0.54,null,9,"-0.540,-0.540",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R"]
[1808,"   T",-0.509,null,8,"-0.509,-0.509",null,null,"    8,8",null,null,"  b","        "," 150/150","T,K,S,N"]
[1809,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","R"]
[1810,"   W",-0.591,null,9,"-0.591,-0.591",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y,W"]
[1811,"   E",-0.328,null,7,"-0.328,-0.328",null,null,"    7,7",null,null,"  e","        "," 150/150","A,V,T,D,M,E,Q"]
[1812,"   L",-0.577,null,9,"-0.577,-0.577",null,null,"    9,9",null,null,"  b","       s"," 150/150","M,R,L"]
[1813,"   S",-0.626,null,9,"-0.626,-0.626",null,null,"    9,9",null,null,"  e","       f"," 150/150","L,T,S"]
[1814,"   Q",-0.515,null,8,"-0.515,-0.515",null,null,"    8,8",null,null,"  e","       f"," 150/150","N,K,Q,H"]
[1815,"   P",-0.304,null,7,"-0.304,-0.304",null,null,"    7,7",null,null,"  e","        "," 150/150","P,T,S"]
[1816,"   D",-0.175,null,6,"-0.175,-0.175",null,null,"    6,6",null,null,"  e","        "," 150/150","D,N,E"]
[1817,"   S",-0.168,null,6,"-0.168,-0.168",null,null,"    6,6",null,null,"  e","        "," 150/150","F,A,N,S,T,P,Q"]
[1818,"   I",-0.247,null,7,"-0.247,-0.247",null,null,"    7,7",null,null,"  b","        "," 149/150","T,A,K,P,M,L,I,V"]
[1819,"   P",-0.21,null,6,"-0.210,-0.210",null,null,"    6,6",null,null,"  e","        "," 150/150","P,R,T,V,S,A"]
[1820,"   Q",-0.396,null,8,"-0.396,-0.396",null,null,"    8,8",null,null,"  e","       f"," 150/150","I,Q,L,T,V"]
[1821,"   H",-0.607,null,9,"-0.607,-0.607",null,null,"    9,9",null,null,"  e","       f"," 150/150","S,H,Y"]
[1822,"   T",-0.165,null,6,"-0.165,-0.165",null,null,"    6,6",null,null,"  e","        "," 150/150","K,S,A,T,P,Q"]
[1823,"   K",-0.643,null,9,"-0.643,-0.643",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q,K"]
[1824,"   I",-0.656,null,9,"-0.656,-0.656",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L"]
[1825,"   R",-0.563,null,9,"-0.563,-0.563",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,R"]
[1826,"   P",-0.485,null,8,"-0.485,-0.485",null,null,"    8,8",null,null,"  e","       f"," 150/150","P,A,S"]
[1827,"   K",-0.595,null,9,"-0.595,-0.595",null,null,"    9,9",null,null,"  e","       f"," 150/150","R,M,K"]
[1828,"   D",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","D"]
[1829,"   V",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","V"]
[1830,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","P"]
[1831,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","G"]
[1832,"   T",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","T"]
[1833,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1834,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1835,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","N"]
[1836,"   I",-0.509,null,8,"-0.509,-0.509",null,null,"    8,8",null,null,"  b","        "," 150/150","V,M,L,Q,I"]
[1837,"   A",-0.647,null,9,"-0.647,-0.647",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,T"]
[1838,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1839,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1840,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","N"]
[1841,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1842,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","G"]
[1843,"   S",-0.586,null,9,"-0.586,-0.586",null,null,"    9,9",null,null,"  e","       f"," 150/150","S,V,T"]
[1844,"   S",-0.169,null,6,"-0.169,-0.169",null,null,"    6,6",null,null,"  e","        "," 150/150","Q,A,N,T,H,L,P,C,S"]
[1845,"   D",-0.588,null,9,"-0.588,-0.588",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,N"]
[1846,"   P",-0.586,null,9,"-0.586,-0.586",null,null,"    9,9",null,null,"  e","       f"," 150/150","A,P"]
[1847,"   S",-0.329,null,7,"-0.329,-0.329",null,null,"    7,7",null,null,"  e","        "," 150/150","S,N,T,C,M,H"]
[1848,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1849,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","R"]
[1850,"   S",-0.429,null,8,"-0.429,-0.429",null,null,"    8,8",null,null,"  b","        "," 150/150","T,S,I,L"]
[1851,"   A",-0.568,null,9,"-0.568,-0.568",null,null,"    9,9",null,null,"  b","       s"," 150/150","T,V,A"]
[1852,"   A",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","A"]
[1853,"   Y",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y"]
[1854,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","N"]
[1855,"   L",-0.251,null,7,"-0.251,-0.251",null,null,"    7,7",null,null,"  b","        "," 150/150","Q,L,H"]
[1856,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","M,L"]
[1857,"   C",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","C"]
[1858,"   A",-0.529,null,8,"-0.529,-0.529",null,null,"    8,8",null,null,"  b","        "," 150/150","S,A,T"]
[1859,"   L",-0.631,null,9,"-0.631,-0.631",null,null,"    9,9",null,null,"  b","       s"," 150/150","L,V"]
[1860,"   T",-0.615,null,9,"-0.615,-0.615",null,null,"    9,9",null,null,"  e","       f"," 150/150","A,T"]
[1861,"   C",-0.073,null,5,"-0.073,-0.073",null,null,"    5,5",null,null,"  b","        "," 150/150","G,Q,C,A,K,S,T"]
[1862,"   T",-0.508,null,8,"-0.508,-0.508",null,null,"    8,8",null,null,"  e","       f"," 150/150","F,T,A,S"]
[1863,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1864,"   N",-0.382,null,8,"-0.382,-0.382",null,null,"    8,8",null,null,"  e","       f"," 150/150","E,G,H,N,D"]
[1865,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","F,L"]
[1866,"   K",-0.491,null,8,"-0.491,-0.491",null,null,"    8,8",null,null,"  e","       f"," 150/150","H,R,K"]
[1867,"   I",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","I"]
[1868,"   E",-0.481,null,8,"-0.481,-0.481",null,null,"    8,8",null,null,"  e","       f"," 150/150","E,Q,D"]
[1869,"   G",-0.331,null,7,"-0.331,-0.331",null,null,"    7,7",null,null,"  e","        "," 150/150","D,N,S,G,E"]
[1870,"   Q",-0.545,null,9,"-0.545,-0.545",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,T,H,R,Q"]
[1871,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1872,"   L",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,L"]
[1873,"   E",-0.636,null,9,"-0.636,-0.636",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q,E"]
[1874,"   T",-0.605,null,9,"-0.605,-0.605",null,null,"    9,9",null,null,"  e","       f"," 150/150","G,T,A"]
[1875,"   S",-0.01,null,5,"-0.010,-0.010",null,null,"    5,5",null,null,"  b","        "," 150/150","W,E,Q,G,T,A,K,N,H,S"]
[1876,"   G",-0.601,null,9,"-0.601,-0.601",null,null,"    9,9",null,null,"  e","       f"," 150/150","G,C"]
[1877,"   L",-0.635,null,9,"-0.635,-0.635",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L"]
[1878,"   C",-0.636,null,9,"-0.636,-0.636",null,null,"    9,9",null,null,"  b","       s"," 150/150","C,L"]
[1879,"   I",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","I"]
[1880,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","P"]
[1881,"   A",-0.473,null,8,"-0.473,-0.473",null,null,"    8,8",null,null,"  b","        "," 150/150","G,K,S,A,T"]
[1882,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","N"]
[1883,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","N"]
[1884,"   T",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","T"]
[1885,"   L",-0.383,null,8,"-0.383,-0.383",null,null,"    8,8",null,null,"  b","        "," 150/150","V,L,M,I"]
[1886,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1887,"   I",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","I"]
[1888,"   V",-0.558,null,9,"-0.558,-0.558",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,V,T"]
[1889,"   S",-0.127,null,6,"-0.127,-0.127",null,null,"    6,6",null,null,"  b","        "," 150/150","H,L,M,S,Q,E,R,G,N,K"]
[1890,"   I",-0.403,null,8,"-0.403,-0.403",null,null,"    8,8",null,null,"  b","        "," 150/150","V,L,I"]
[1891,"   S",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","S"]
[1892,"   K",-0.363,null,7,"-0.363,-0.363",null,null,"    7,7",null,null,"  e","        "," 150/150","D,N,K,I,E"]
[1893,"   T",-0.095,null,6,"-0.095,-0.095",null,null,"    6,6",null,null,"  e","        "," 150/150","T,K,R"]
[1894,"   L",-0.633,null,9,"-0.633,-0.633",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,L"]
[1895,"   A",-0.568,null,9,"-0.568,-0.568",null,null,"    9,9",null,null,"  e","       f"," 150/150","G,S,A"]
[1896,"   A",0.275,null,3," 0.275, 0.275",null,null,"    3,3",null,null,"  e","        "," 150/150","H,L,M,V,R,E,Q,A,N,T"]
[1897,"   N",-0.481,null,8,"-0.481,-0.481",null,null,"    8,8",null,null,"  e","       f"," 150/150","S,K,N,R,L,H"]
[1898,"   E",-0.539,null,9,"-0.539,-0.539",null,null,"    9,9",null,null,"  e","       f"," 150/150","A,D,E"]
[1899,"   P",-0.239,null,7,"-0.239,-0.239",null,null,"    7,7",null,null,"  e","        "," 150/150","P,Y,S,T"]
[1900,"   H",-0.569,null,9,"-0.569,-0.569",null,null,"    9,9",null,null,"  e","       f"," 150/150","R,Q,H"]
[1901,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1902,"   T",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","T"]
[1903,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1904,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","E"]
[1905,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1906,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1907,"   E",-0.197,null,6,"-0.197,-0.197",null,null,"    6,6",null,null,"  e","        "," 150/150","E,Q,R,T,K,A,H,V"]
[1908,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","E"]
[1909,"   C",-0.589,null,9,"-0.589,-0.589",null,null,"    9,9",null,null,"  b","       s"," 150/150","C,S"]
[1910,"   I",-0.531,null,8,"-0.531,-0.531",null,null,"    8,8",null,null,"  b","        "," 150/150","I,M,L"]
[1911,"   S",-0.44,null,8,"-0.440,-0.440",null,null,"    8,8",null,null,"  e","       f"," 150/150","A,S,T,H,G,Q,E"]
[1912,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","G"]
[1913,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1914,"   S",0.155,null,4," 0.155, 0.155",null,null,"    4,4",null,null,"  e","        "," 150/150","G,R,Q,V,K,S"]
[1915,"   K",0.506,null,2," 0.506, 0.506",null,null,"    2,2",null,null,"  e","        "," 150/150","S,V,L,M,H,I,N,A,K,E,Q,G,R"]
[1916,"   S",-0.653,null,9,"-0.653,-0.653",null,null,"    9,9",null,null,"  b","       s"," 150/150","S,I"]
[1917,"   S",-0.06,null,5,"-0.060,-0.060",null,null,"    5,5",null,null,"  e","        "," 150/150","S,N,T,D,P"]
[1918,"   I",-0.621,null,9,"-0.621,-0.621",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,Y,F"]
[1919,"   E",-0.584,null,9,"-0.584,-0.584",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,E"]
[1920,"   L",-0.587,null,9,"-0.587,-0.587",null,null,"    9,9",null,null,"  b","       s"," 150/150","M,L"]
[1921,"   K",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","K"]
[1922,"   H",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","H"]
[1923,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1924,"   C",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","C"]
[1925,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1926,"   E",-0.636,null,9,"-0.636,-0.636",null,null,"    9,9",null,null,"  e","       f"," 150/150","E,Q"]
[1927,"   Y",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y"]
[1928,"   M",-0.542,null,9,"-0.542,-0.542",null,null,"    9,9",null,null,"  b","       s"," 150/150","M,I"]
[1929,"   T",-0.615,null,9,"-0.615,-0.615",null,null,"    9,9",null,null,"  b","       s"," 150/150","T,S,A"]
[1930,"   P",-0.585,null,9,"-0.585,-0.585",null,null,"    9,9",null,null,"  e","       f"," 150/150","S,P"]
[1931,"   W",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","W"]
[1932,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1933,"   S",0.715,null,1," 0.715, 0.715",null,null,"    1,1",null,null,"  e","        "," 150/150","A,K,N,R,G,V,S,P,L"]
[1934,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","N"]
[1935,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1936,"   V",-0.346,null,7,"-0.346,-0.346",null,null,"    7,7",null,null,"  b","        "," 150/150","A,V,T,L,P"]
[1937,"   R",-0.393,null,8,"-0.393,-0.393",null,null,"    8,8",null,null,"  e","       f"," 150/150","R,K"]
[1938,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1939,"   C",-0.326,null,7,"-0.326,-0.326",null,null,"    7,7",null,null,"  b","        "," 149/150","C,S,V,Y,H"]
[1940,"   K",-0.392,null,8,"-0.392,-0.392",null,null,"    8,8",null,null,"  e","       f"," 149/150","R,K,N"]
[1941,"   H",0.212,null,4," 0.212, 0.212",null,null,"    4,4",null,null,"  e","        "," 148/150","H,P,L,S,Q,G,R,T,A"]
[1942,"   N",0.358,null,3," 0.358, 0.358",null,null,"    3,3",null,null,"  e","        "," 149/150","T,A,N,Q,R,C,S,H,P"]
[1943,"   D",-0.534,null,9,"-0.534,-0.534",null,null,"    9,9",null,null,"  e","       f"," 149/150","E,D"]
[1944,"   D",-0.1,null,6,"-0.100,-0.100",null,null,"    6,6",null,null,"  e","        "," 149/150","E,N,D"]
[1945,"   A",0.379,null,3," 0.379, 0.379",null,null,"    3,3",null,null,"  e","        "," 148/150","Q,G,Y,T,N,A,P,S,D"]
[1946,"   K",-0.417,null,8,"-0.417,-0.417",null,null,"    8,8",null,null,"  e","       f"," 150/150","K,R,Q"]
[1947,"   R",-0.493,null,8,"-0.493,-0.493",null,null,"    8,8",null,null,"  e","       f"," 150/150","K,R,H"]
[1948,"   Q",-0.4,null,8,"-0.400,-0.400",null,null,"    8,8",null,null,"  e","       f"," 150/150","Q,L,R,H,Y,V,K"]
[1949,"   R",-0.357,null,7,"-0.357,-0.357",null,null,"    7,7",null,null,"  e","        "," 150/150","A,S,N,K,R,Q"]
[1950,"   V",-0.512,null,8,"-0.512,-0.512",null,null,"    8,8",null,null,"  b","        "," 150/150","L,M,I,V"]
[1951,"   T",0.342,null,3," 0.342, 0.342",null,null,"    3,3",null,null,"  b","        "," 150/150","G,T,A,N,I,L,V,S"]
[1952,"   A",0.625,null,1," 0.625, 0.625",null,null,"    1,1",null,null,"  e","        "," 150/150","S,D,F,L,H,I,T,A,V,C,M,N,K,Q,E,G,R"]
[1953,"   I",-0.626,null,9,"-0.626,-0.626",null,null,"    9,9",null,null,"  b","       s"," 150/150","I,V"]
[1954,"   L",-0.467,null,8,"-0.467,-0.467",null,null,"    8,8",null,null,"  b","        "," 150/150","L,W,I"]
[1955,"   D",-0.225,null,6,"-0.225,-0.225",null,null,"    6,6",null,null,"  e","        "," 150/150","Q,E,K,N,D"]
[1956,"   K",-0.36,null,7,"-0.360,-0.360",null,null,"    7,7",null,null,"  e","        "," 150/150","R,E,Q,K,T,D"]
[1957,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1958,"   I",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","I"]
[1959,"   T",0.015,null,5," 0.015, 0.015",null,null,"    5,5",null,null,"  e","        "," 150/150","V,S,C,L,I,H,N,T,E"]
[1960,"   M",-0.346,null,7,"-0.346,-0.346",null,null,"    7,7",null,null,"  b","        "," 150/150","I,L,M,V"]
[1961,"   T",-0.652,null,9,"-0.652,-0.652",null,null,"    9,9",null,null,"  b","       s"," 150/150","S,T"]
[1962,"   I",-0.462,null,8,"-0.462,-0.462",null,null,"    8,8",null,null,"  b","        "," 150/150","A,V,L,I"]
[1963,"   N",-0.1,null,6,"-0.100,-0.100",null,null,"    6,6",null,null,"  e","        "," 150/150","T,K,S,N,D,E,Q"]
[1964,"   E",-0.589,null,9,"-0.589,-0.589",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q,E"]
[1965,"   K",0.033,null,5," 0.033, 0.033",null,null,"    5,5",null,null,"  e","        "," 150/150","I,V,S,D,G,E,K,T"]
[1966,"   Q",-0.338,null,7,"-0.338,-0.338",null,null,"    7,7",null,null,"  e","        "," 150/150","E,Q,T,A,D"]
[1967,"   M",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","M"]
[1968,"   Y",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","Y"]
[1969,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","P"]
[1970,"   S",-0.656,null,9,"-0.656,-0.656",null,null,"    9,9",null,null,"  e","       f"," 150/150","N,S"]
[1971,"   I",-0.392,null,8,"-0.392,-0.392",null,null,"    8,8",null,null,"  b","        "," 150/150","I,M,F,V"]
[1972,"   Q",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 150/150","Q"]
[1973,"   A",-0.638,null,9,"-0.638,-0.638",null,null,"    9,9",null,null,"  b","       s"," 150/150","A,I"]
[1974,"   K",-0.642,null,9,"-0.642,-0.642",null,null,"    9,9",null,null,"  e","       f"," 150/150","K,T"]
[1975,"   I",-0.656,null,9,"-0.656,-0.656",null,null,"    9,9",null,null,"  b","       s"," 150/150","V,I"]
[1976,"   W",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","W"]
[1977,"   G",-0.237,null,7,"-0.237,-0.237",null,null,"    7,7",null,null,"  b","        "," 150/150","N,A,S,G"]
[1978,"   S",-0.262,null,7,"-0.262,-0.262",null,null,"    7,7",null,null,"  e","        "," 150/150","H,K,N,S,T"]
[1979,"   L",-0.278,null,7,"-0.278,-0.278",null,null,"    7,7",null,null,"  b","        "," 150/150","I,L,M,F,V"]
[1980,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","G"]
[1981,"   Q",0.01,null,5," 0.010, 0.010",null,null,"    5,5",null,null,"  e","        "," 150/150","I,H,M,D,R,G,Q,E,K,T"]
[1982,"   I",-0.368,null,7,"-0.368,-0.368",null,null,"    7,7",null,null,"  b","        "," 150/150","L,I,V"]
[1983,"   T",-0.056,null,5,"-0.056,-0.056",null,null,"    5,5",null,null,"  b","        "," 150/150","S,A,T,G,E,P,H"]
[1984,"   D",0.092,null,4," 0.092, 0.092",null,null,"    4,4",null,null,"  e","        "," 150/150","Q,E,D"]
[1985,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1986,"   L",-0.487,null,8,"-0.487,-0.487",null,null,"    8,8",null,null,"  b","        "," 150/150","V,I,L"]
[1987,"   D",-0.636,null,9,"-0.636,-0.636",null,null,"    9,9",null,null,"  e","       f"," 150/150","G,D"]
[1988,"   V",0.038,null,5," 0.038, 0.038",null,null,"    5,5",null,null,"  b","        "," 150/150","S,V,D,C,L,M,I,T,G"]
[1989,"   V",-0.524,null,8,"-0.524,-0.524",null,null,"    8,8",null,null,"  b","        "," 150/150","V,T,I"]
[1990,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","L"]
[1991,"   D",-0.637,null,9,"-0.637,-0.637",null,null,"    9,9",null,null,"  e","       f"," 150/150","D,N"]
[1992,"   S",-0.183,null,6,"-0.183,-0.183",null,null,"    6,6",null,null,"  b","        "," 150/150","G,R,T,N,I,M,C,S"]
[1993,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","F"]
[1994,"   I",-0.481,null,8,"-0.481,-0.481",null,null,"    8,8",null,null,"  b","        "," 150/150","M,L,I"]
[1995,"   K",-0.095,null,6,"-0.095,-0.095",null,null,"    6,6",null,null,"  e","        "," 150/150","R,Q,H,S,K"]
[1996,"   T",-0.351,null,7,"-0.351,-0.351",null,null,"    7,7",null,null,"  e","        "," 150/150","C,A,K,T,R"]
[1997,"   S",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 150/150","S"]
[1998,"   A",-0.197,null,6,"-0.197,-0.197",null,null,"    6,6",null,null,"  b","        "," 150/150","L,M,I,V,E,G,T,A"]
[1999,"   T",0.475,null,2," 0.475, 0.475",null,null,"    2,2",null,null,"  e","        "," 150/150","C,D,S,I,H,A,K,N,T,G,R,E,Q"]
[2000,"   G",0.292,null,3," 0.292, 0.292",null,null,"    3,3",null,null,"  e","        "," 150/150","R,G,Y,N,H,S,D,C,F"]
[2001,"   G",-0.517,null,8,"-0.517,-0.517",null,null,"    8,8",null,null,"  e","       f"," 150/150","G,R,E"]
[2002,"   L",-0.326,null,7,"-0.326,-0.326",null,null,"    7,7",null,null,"  b","        "," 149/150","H,L,F,V"]
[2003,"   G",-0.602,null,9,"-0.602,-0.602",null,null,"    9,9",null,null,"  b","       s"," 149/150","G,S"]
[2004,"   S",-0.591,null,9,"-0.591,-0.591",null,null,"    9,9",null,null,"  b","       s"," 149/150","T,S,P,L"]
[2005,"   I",0.555,null,1," 0.555, 0.555",null,null,"    1,1",null,null,"  b","        "," 149/150","Q,R,A,N,P,L,M,H,I,S,V,D"]
[2006,"   K",-0.139,null,6,"-0.139,-0.139",null,null,"    6,6",null,null,"  e","        "," 149/150","K,T,R,Q,S,V,M,P,H"]
[2007,"   A",-0.463,null,8,"-0.463,-0.463",null,null,"    8,8",null,null,"  b","        "," 149/150","I,S,A,V"]
[2008,"   E",-0.635,null,9,"-0.635,-0.635",null,null,"    9,9",null,null,"  e","       f"," 149/150","D,E"]
[2009,"   V",-0.474,null,8,"-0.474,-0.474",null,null,"    8,8",null,null,"  b","        "," 149/150","T,V,I"]
[2010,"   M",-0.572,null,9,"-0.572,-0.572",null,null,"    9,9",null,null,"  b","       s"," 149/150","I,L,M"]
[2011,"   A",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","A"]
[2012,"   D",-0.637,null,9,"-0.637,-0.637",null,null,"    9,9",null,null,"  e","       f"," 149/150","E,D"]
[2013,"   T",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","T"]
[2014,"   A",-0.526,null,8,"-0.526,-0.526",null,null,"    8,8",null,null,"  b","        "," 149/150","A,S,T"]
[2015,"   V",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","V"]
[2016,"   A",-0.607,null,9,"-0.607,-0.607",null,null,"    9,9",null,null,"  b","       s"," 149/150","T,A,S"]
[2017,"   L",-0.631,null,9,"-0.631,-0.631",null,null,"    9,9",null,null,"  b","       s"," 149/150","L,V"]
[2018,"   A",-0.608,null,9,"-0.608,-0.608",null,null,"    9,9",null,null,"  b","       s"," 149/150","S,A,T"]
[2019,"   S",-0.588,null,9,"-0.588,-0.588",null,null,"    9,9",null,null,"  e","       f"," 149/150","A,S,Y"]
[2020,"   G",-0.065,null,5,"-0.065,-0.065",null,null,"    5,5",null,null,"  b","        "," 149/150","A,V,S,G,Y"]
[2021,"   N",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 149/150","N"]
[2022,"   V",-0.583,null,9,"-0.583,-0.583",null,null,"    9,9",null,null,"  b","       s"," 149/150","T,K,V,I"]
[2023,"   K",-0.297,null,7,"-0.297,-0.297",null,null,"    7,7",null,null,"  e","        "," 149/150","A,K,S,P,Q,E,L"]
[2024,"   L",-0.521,null,8,"-0.521,-0.521",null,null,"    8,8",null,null,"  b","        "," 149/150","I,L,V"]
[2025,"   V",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 149/150","V"]
[2026,"   S",-0.511,null,8,"-0.511,-0.511",null,null,"    8,8",null,null,"  b","        "," 149/150","T,A,S,G"]
[2027,"   S",-0.116,null,6,"-0.116,-0.116",null,null,"    6,6",null,null,"  e","        "," 149/150","D,S,L,M,T,N,A,K,R"]
[2028,"   K",-0.64,null,9,"-0.640,-0.640",null,null,"    9,9",null,null,"  e","       f"," 149/150","I,K"]
[2029,"   V",-0.279,null,7,"-0.279,-0.279",null,null,"    7,7",null,null,"  b","        "," 149/150","I,L,V,T"]
[2030,"   I",-0.655,null,9,"-0.655,-0.655",null,null,"    9,9",null,null,"  b","       s"," 149/150","I,L"]
[2031,"   G",0.297,null,3," 0.297, 0.297",null,null,"    3,3",null,null,"  e","        "," 149/150","S,I,N,A,T,W,G,E"]
[2032,"   R",-0.589,null,9,"-0.589,-0.589",null,null,"    9,9",null,null,"  e","       f"," 149/150","K,R"]
[2033,"   M",-0.35,null,7,"-0.350,-0.350",null,null,"    7,7",null,null,"  b","        "," 148/150","V,I,M,L"]
[2034,"   C",-0.441,null,8,"-0.441,-0.441",null,null,"    8,8",null,null,"  b","        "," 148/150","C,D,M,I,H"]
[2035,"   K",-0.317,null,7,"-0.317,-0.317",null,null,"    7,7",null,null,"  e","        "," 148/150","N,S,K,Q,L,G,R"]
[2036,"   I",-0.336,null,7,"-0.336,-0.336",null,null,"    7,7",null,null,"  b","        "," 148/150","V,A,F,L,M,I"]
[2037,"   I",-0.224,null,6,"-0.224,-0.224",null,null,"    6,6",null,null,"  b","        "," 148/150","I,L,M,F,V"]
[2038,"   D",-0.14,null,6,"-0.140,-0.140",null,null,"    6,6",null,null,"  e","        "," 148/150","D,S,E"]
[2039,"   K",-0.397,null,8,"-0.397,-0.397",null,null,"    8,8",null,null,"  e","       f"," 148/150","K,E,R"]
[2040,"   T",-0.615,null,9,"-0.615,-0.615",null,null,"    9,9",null,null,"  e","       f"," 148/150","S,T"]
[2041,"   C",-0.421,null,8,"-0.421,-0.421",null,null,"    8,8",null,null,"  b","        "," 148/150","G,A,S,F,C"]
[2042,"   L",0.339,null,3," 0.339, 0.339",null,null,"    3,3",null,null,"  e","        "," 148/150","T,N,A,K,Q,V,S,H,I,L,M"]
[2043,"   S",-0.526,null,8,"-0.526,-0.526",null,null,"    8,8",null,null,"  e","       f"," 148/150","A,S,N,T"]
[2044,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 148/150","P"]
[2045,"   T",-0.537,null,9,"-0.537,-0.537",null,null,"    9,9",null,null,"  e","       f"," 148/150","T,V,Q"]
[2046,"   P",1.482,null,1," 1.482, 1.482",null,null,"    1,1",null,null,"  e","        "," 148/150","S,V,L,P,H,N,A,T,Q"]
[2047,"   T",0.287,null,3," 0.287, 0.287",null,null,"    3,3",null,null,"  e","        "," 148/150","C,F,S,I,H,M,L,A,N,T,Y,R,Q"]
[2048,"   L",-0.63,null,9,"-0.630,-0.630",null,null,"    9,9",null,null,"  b","       s"," 148/150","V,L"]
[2049,"   E",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  e","       f"," 148/150","V,E"]
[2050,"   Q",-0.419,null,8,"-0.419,-0.419",null,null,"    8,8",null,null,"  e","       f"," 148/150","V,N,A,K,E,Q,R"]
[2051,"   H",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 148/150","H"]
[2052,"   L",0.157,null,4," 0.157, 0.157",null,null,"    4,4",null,null,"  b","        "," 148/150","P,M,L,I,S,V,T,N,K,A"]
[2053,"   M",-0.449,null,8,"-0.449,-0.449",null,null,"    8,8",null,null,"  e","       f"," 148/150","L,R,M"]
[2054,"   W",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 148/150","W"]
[2055,"   D",-0.276,null,7,"-0.276,-0.276",null,null,"    7,7",null,null,"  b","        "," 148/150","H,P,D,N,S"]
[2056,"   D",-0.584,null,9,"-0.584,-0.584",null,null,"    9,9",null,null,"  e","       f"," 148/150","E,D,S"]
[2057,"   I",-0.654,null,9,"-0.654,-0.654",null,null,"    9,9",null,null,"  b","       s"," 148/150","T,I"]
[2058,"   A",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 148/150","A"]
[2059,"   I",-0.547,null,9,"-0.547,-0.547",null,null,"    9,9",null,null,"  b","       s"," 148/150","V,N,T,P,I"]
[2060,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 148/150","L"]
[2061,"   A",-0.273,null,7,"-0.273,-0.273",null,null,"    7,7",null,null,"  b","        "," 148/150","L,G,T,N,S,A"]
[2062,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 148/150","R"]
[2063,"   Y",-0.625,null,9,"-0.625,-0.625",null,null,"    9,9",null,null,"  b","       s"," 148/150","Y,F"]
[2064,"   M",-0.584,null,9,"-0.584,-0.584",null,null,"    9,9",null,null,"  b","       s"," 148/150","L,M,F"]
[2065,"   L",-0.631,null,9,"-0.631,-0.631",null,null,"    9,9",null,null,"  b","       s"," 148/150","L,V"]
[2066,"   M",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 148/150","I,M,F"]
[2067,"   L",-0.574,null,9,"-0.574,-0.574",null,null,"    9,9",null,null,"  b","       s"," 148/150","L,Q,I"]
[2068,"   S",-0.656,null,9,"-0.656,-0.656",null,null,"    9,9",null,null,"  b","       s"," 148/150","S,T"]
[2069,"   F",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 148/150","F,C"]
[2070,"   N",-0.575,null,9,"-0.575,-0.575",null,null,"    9,9",null,null,"  e","       f"," 148/150","S,N,D,H"]
[2071,"   N",-0.649,null,9,"-0.649,-0.649",null,null,"    9,9",null,null,"  e","       f"," 147/150","D,N,X"]
[2072,"   S",-0.273,null,7,"-0.273,-0.273",null,null,"    7,7",null,null,"  b","        "," 147/150","C,S,X,A"]
[2073,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 148/150","L"]
[2074,"   D",-0.635,null,9,"-0.635,-0.635",null,null,"    9,9",null,null,"  e","       f"," 148/150","N,D"]
[2075,"   V",-0.653,null,9,"-0.653,-0.653",null,null,"    9,9",null,null,"  b","       s"," 148/150","V,I"]
[2076,"   A",-0.106,null,6,"-0.106,-0.106",null,null,"    6,6",null,null,"  b","        "," 148/150","T,A,Y,G,C,S,V,I"]
[2077,"   A",0.247,null,3," 0.247, 0.247",null,null,"    3,3",null,null,"  e","        "," 148/150","L,I,H,S,C,R,N,K,A,T"]
[2078,"   H",-0.525,null,8,"-0.525,-0.525",null,null,"    8,8",null,null,"  e","       f"," 146/150","S,N,H,P"]
[2079,"   L",-0.576,null,9,"-0.576,-0.576",null,null,"    9,9",null,null,"  b","       s"," 146/150","V,I,L"]
[2080,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 146/150","P"]
[2081,"   Y",0.064,null,5," 0.064, 0.064",null,null,"    5,5",null,null,"  b","        "," 146/150","Y,H,L,R,F,V,A"]
[2082,"   L",-0.465,null,8,"-0.465,-0.465",null,null,"    8,8",null,null,"  b","        "," 146/150","L,I,V"]
[2083,"   F",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 146/150","F,V"]
[2084,"   H",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 146/150","H"]
[2085,"   V",0.023,null,5," 0.023, 0.023",null,null,"    5,5",null,null,"  b","        "," 146/150","T,A,Y,V,S,F,M,L,I"]
[2086,"   V",-0.481,null,8,"-0.481,-0.481",null,null,"    8,8",null,null,"  b","        "," 146/150","V,A,I"]
[2087,"   T",-0.578,null,9,"-0.578,-0.578",null,null,"    9,9",null,null,"  b","       s"," 146/150","C,S,T"]
[2088,"   F",0.042,null,5," 0.042, 0.042",null,null,"    5,5",null,null,"  b","        "," 146/150","F,V,A,M,L"]
[2089,"   L",-0.631,null,9,"-0.631,-0.631",null,null,"    9,9",null,null,"  b","       s"," 147/150","L,M"]
[2090,"   V",-0.478,null,8,"-0.478,-0.478",null,null,"    8,8",null,null,"  b","        "," 147/150","V,L,I"]
[2091,"   A",-0.281,null,7,"-0.281,-0.281",null,null,"    7,7",null,null,"  b","        "," 147/150","Y,H,N,A,S,C,F"]
[2092,"   T",-0.477,null,8,"-0.477,-0.477",null,null,"    8,8",null,null,"  b","        "," 147/150","T,A,S,C,I"]
[2093,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 147/150","G"]
[2094,"   P",-0.422,null,8,"-0.422,-0.422",null,null,"    8,8",null,null,"  e","       f"," 147/150","T,S,N,P"]
[2095,"   L",-0.132,null,6,"-0.132,-0.132",null,null,"    6,6",null,null,"  b","        "," 147/150","S,V,I,L,M,P"]
[2096,"   S",-0.491,null,8,"-0.491,-0.491",null,null,"    8,8",null,null,"  b","        "," 147/150","P,A,S,T"]
[2097,"   L",-0.491,null,8,"-0.491,-0.491",null,null,"    8,8",null,null,"  b","        "," 147/150","F,I,M,L"]
[2098,"   R",-0.636,null,9,"-0.636,-0.636",null,null,"    9,9",null,null,"  e","       f"," 147/150","R,Q"]
[2099,"   A",-0.646,null,9,"-0.646,-0.646",null,null,"    9,9",null,null,"  b","       s"," 147/150","S,A"]
[2100,"   S",-0.528,null,8,"-0.528,-0.528",null,null,"    8,8",null,null,"  b","        "," 147/150","C,S,A"]
[2101,"   T",-0.204,null,6,"-0.204,-0.204",null,null,"    6,6",null,null,"  e","        "," 147/150","I,L,V,T"]
[2102,"   H",-0.646,null,9,"-0.646,-0.646",null,null,"    9,9",null,null,"  e","       f"," 147/150","L,H"]
[2103,"   G",-0.51,null,8,"-0.510,-0.510",null,null,"    8,8",null,null,"  b","        "," 147/150","C,G"]
[2104,"   L",-0.63,null,9,"-0.630,-0.630",null,null,"    9,9",null,null,"  b","       s"," 148/150","L,F"]
[2105,"   V",-0.585,null,9,"-0.585,-0.585",null,null,"    9,9",null,null,"  b","       s"," 148/150","L,M,A,V"]
[2106,"   I",-0.558,null,9,"-0.558,-0.558",null,null,"    9,9",null,null,"  b","       s"," 148/150","I,V,T"]
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[2275,"   I",-0.501,null,8,"-0.501,-0.501",null,null,"    8,8",null,null,"  b","        "," 144/150","V,I,M,L"]
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[2278,"   T",-0.611,null,9,"-0.611,-0.611",null,null,"    9,9",null,null,"  e","       f"," 144/150","R,T,S"]
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[2284,"   L",-0.63,null,9,"-0.630,-0.630",null,null,"    9,9",null,null,"  e","       f"," 144/150","I,L"]
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[2304,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 144/150","L"]
[2305,"   D",-0.418,null,8,"-0.418,-0.418",null,null,"    8,8",null,null,"  e","       f"," 144/150","S,D,E,H"]
[2306,"   E",-0.134,null,6,"-0.134,-0.134",null,null,"    6,6",null,null,"  e","        "," 144/150","Q,E,K,V,D"]
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[2308,"   N",0.172,null,4," 0.172, 0.172",null,null,"    4,4",null,null,"  e","        "," 144/150","P,I,S,D,F,T,K,A,N"]
[2309,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 142/150","L"]
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[2311,"   S",-0.426,null,8,"-0.426,-0.426",null,null,"    8,8",null,null,"  b","        "," 144/150","P,E,G,T,S,A,D"]
[2312,"   A",0.003,null,5," 0.003, 0.003",null,null,"    5,5",null,null,"  b","        "," 144/150","P,H,A,S,T,C"]
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[2315,"   A",-0.52,null,8,"-0.520,-0.520",null,null,"    8,8",null,null,"  e","       f"," 144/150","S,A,G"]
[2316,"   L",-0.575,null,9,"-0.575,-0.575",null,null,"    9,9",null,null,"  b","       s"," 144/150","M,L,F"]
[2317,"   L",-0.512,null,8,"-0.512,-0.512",null,null,"    8,8",null,null,"  b","        "," 144/150","M,L,V"]
[2318,"   E",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 144/150","E"]
[2319,"   Q",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 144/150","Q"]
[2320,"   N",-0.609,null,9,"-0.609,-0.609",null,null,"    9,9",null,null,"  b","       s"," 144/150","I,N,S"]
[2321,"   L",-0.631,null,9,"-0.631,-0.631",null,null,"    9,9",null,null,"  b","       s"," 144/150","L,I"]
[2322,"   H",-0.447,null,8,"-0.447,-0.447",null,null,"    8,8",null,null,"  e","       f"," 144/150","I,H,R,L,Q,D"]
[2323,"   T",-0.458,null,8,"-0.458,-0.458",null,null,"    8,8",null,null,"  e","       f"," 144/150","C,T,N,S,I,M"]
[2324,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 144/150","L"]
[2325,"   D",-0.409,null,8,"-0.409,-0.409",null,null,"    8,8",null,null,"  e","       f"," 144/150","D,N,K,I,E"]
[2326,"   S",-0.178,null,6,"-0.178,-0.178",null,null,"    6,6",null,null,"  e","        "," 144/150","I,S,C,F,E,Q,R,T,N"]
[2327,"   L",-0.066,null,5,"-0.066,-0.066",null,null,"    5,5",null,null,"  e","        "," 144/150","H,I,L,M,F,S,Q,N"]
[2328,"   R",0.07,null,5," 0.070, 0.070",null,null,"    5,5",null,null,"  e","        "," 144/150","R,G,Q,H,N,A,S"]
[2329,"   I",0.894,null,1," 0.894, 0.894",null,null,"    1,1",null,null,"  e","        "," 144/150","L,M,H,I,V,S,C,T,N,A,K"]
[2330,"   F",-0.632,null,9,"-0.632,-0.632",null,null,"    9,9",null,null,"  b","       s"," 144/150","L,F"]
[2331,"   N",0.232,null,3," 0.232, 0.232",null,null,"    3,3",null,null,"  e","        "," 144/150","D,T,N,E"]
[2332,"   D",1.583,null,1," 1.583, 1.583",null,null,"    1,1",null,null,"  e","        "," 144/150","R,E,Y,A,K,N,T,M,I,H,S,D"]
[2333,"   K",0.906,null,1," 0.906, 0.906",null,null,"    1,1",null,null,"  e","        "," 144/150","P,L,D,Q,E,R,T,K,A,N"]
[2334,"   S",0.27,null,3," 0.270, 0.270",null,null,"    3,3",null,null,"  e","        "," 144/150","R,P,V,N,S,T,C"]
[2335,"   P",0.041,null,5," 0.041, 0.041",null,null,"    5,5",null,null,"  b","        "," 144/150","F,V,N,I,P,M,L"]
[2336,"   E",0.113,null,4," 0.113, 0.113",null,null,"    4,4",null,null,"  e","        "," 144/150","K,S,A,D,Q,E,R"]
[2337,"   E",2.036,null,1," 2.036, 2.036",null,null,"    1,1",null,null,"  e","        "," 144/150","S,V,C,F,D,H,N,K,T,R,Q,E,Y"]
[2338,"   V",-0.236,null,7,"-0.236,-0.236",null,null,"    7,7",null,null,"  b","        "," 144/150","L,M,I,V,C"]
[2339,"   F",-0.446,null,8,"-0.446,-0.446",null,null,"    8,8",null,null,"  b","        "," 144/150","I,L,M,F,N,V"]
[2340,"   M",-0.54,null,9,"-0.540,-0.540",null,null,"    9,9",null,null,"  b","       s"," 144/150","T,M,L,I"]
[2341,"   A",0.927,null,1," 0.927, 0.927",null,null,"    1,1",null,null,"  e","        "," 144/150","K,A,N,T,R,E,Q,S,C,D,L,P"]
[2342,"   I",-0.106,null,6,"-0.106,-0.106",null,null,"    6,6",null,null,"  b","        "," 144/150","T,A,Y,V,S,C,F,I"]
[2343,"   R",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 144/150","R"]
[2344,"   N",0.495,null,2," 0.495, 0.495",null,null,"    2,2",null,null,"  e","        "," 144/150","V,D,C,P,H,T,N,K,E,Q,R"]
[2345,"   P",0.285,null,3," 0.285, 0.285",null,null,"    3,3",null,null,"  e","        "," 144/150","K,S,A,L,R,P,Q"]
[2346,"   L",-0.573,null,9,"-0.573,-0.573",null,null,"    9,9",null,null,"  b","       s"," 144/150","F,Y,L"]
[2347,"   E",-0.524,null,8,"-0.524,-0.524",null,null,"    8,8",null,null,"  e","       f"," 144/150","Y,I,E,D"]
[2348,"   W",0.293,null,3," 0.293, 0.293",null,null,"    3,3",null,null,"  e","        "," 144/150","G,Y,W,S,F,C,L,P"]
[2349,"   H",-0.377,null,7,"-0.377,-0.377",null,null,"    7,7",null,null,"  e","        "," 144/150","D,Q,E,G,H"]
[2350,"   C",-0.452,null,8,"-0.452,-0.452",null,null,"    8,8",null,null,"  b","        "," 144/150","C,F,S,Y"]
[2351,"   K",-0.641,null,9,"-0.641,-0.641",null,null,"    9,9",null,null,"  e","       f"," 144/150","K,G"]
[2352,"   Q",-0.459,null,8,"-0.459,-0.459",null,null,"    8,8",null,null,"  e","       f"," 144/150","L,Q,P,A,K"]
[2353,"   M",-0.508,null,8,"-0.508,-0.508",null,null,"    8,8",null,null,"  b","        "," 144/150","M,L"]
[2354,"   D",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 144/150","D"]
[2355,"   H",-0.085,null,6,"-0.085,-0.085",null,null,"    6,6",null,null,"  e","        "," 144/150","D,V,N,Y,H,L,Q"]
[2356,"   F",0.243,null,3," 0.243, 0.243",null,null,"    3,3",null,null,"  b","        "," 144/150","S,F,C,D,A,T,E,Q,Y"]
[2357,"   V",-0.583,null,9,"-0.583,-0.583",null,null,"    9,9",null,null,"  b","       s"," 144/150","V,I,M"]
[2358,"   G",-0.597,null,9,"-0.597,-0.597",null,null,"    9,9",null,null,"  b","       s"," 144/150","G,T"]
[2359,"   L",-0.631,null,9,"-0.631,-0.631",null,null,"    9,9",null,null,"  b","       s"," 144/150","L,I"]
[2360,"   N",-0.554,null,9,"-0.554,-0.554",null,null,"    9,9",null,null,"  b","       s"," 144/150","Q,Y,S,K,N"]
[2361,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 144/150","F"]
[2362,"   N",0.505,null,2," 0.505, 0.505",null,null,"    2,2",null,null,"  e","        "," 144/150","S,M,T,A,K,N,E,G,R"]
[2363,"   S",0.553,null,1," 0.553, 0.553",null,null,"    1,1",null,null,"  b","        "," 144/150","H,S,F,C,D,G,E,Q,Y,K,N,A,T"]
[2364,"   N",-0.328,null,7,"-0.328,-0.328",null,null,"    7,7",null,null,"  e","        "," 144/150","Y,H,E,P,N,S,K"]
[2365,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 144/150","F"]
[2366,"   N",-0.526,null,8,"-0.526,-0.526",null,null,"    8,8",null,null,"  b","        "," 144/150","Y,H,N"]
[2367,"   F",-0.577,null,9,"-0.577,-0.577",null,null,"    9,9",null,null,"  b","       s"," 144/150","F,C,T"]
[2368,"   A",-0.646,null,9,"-0.646,-0.646",null,null,"    9,9",null,null,"  b","       s"," 144/150","S,A"]
[2369,"   L",-0.392,null,8,"-0.392,-0.392",null,null,"    8,8",null,null,"  b","        "," 144/150","C,F,V,L,M"]
[2370,"   V",-0.582,null,9,"-0.582,-0.582",null,null,"    9,9",null,null,"  b","       s"," 144/150","L,M,V,A"]
[2371,"   G",-0.383,null,8,"-0.383,-0.383",null,null,"    8,8",null,null,"  b","        "," 144/150","F,V,A,G"]
[2372,"   H",-0.605,null,9,"-0.605,-0.605",null,null,"    9,9",null,null,"  b","       s"," 144/150","L,H,Y"]
[2373,"   L",-0.63,null,9,"-0.630,-0.630",null,null,"    9,9",null,null,"  b","       s"," 144/150","F,L"]
[2374,"   L",-0.202,null,6,"-0.202,-0.202",null,null,"    6,6",null,null,"  b","        "," 144/150","F,V,A,I,L,M"]
[2375,"   K",-0.641,null,9,"-0.641,-0.641",null,null,"    9,9",null,null,"  e","       f"," 144/150","K,L"]
[2376,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 144/150","G"]
[2377,"   Y",0.302,null,3," 0.302, 0.302",null,null,"    3,3",null,null,"  e","        "," 144/150","F,V,Y,L"]
[2378,"   R",-0.634,null,9,"-0.634,-0.634",null,null,"    9,9",null,null,"  e","       f"," 144/150","R,Y"]
[2379,"   H",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 144/150","H"]
[2380,"   P",0.326,null,3," 0.326, 0.326",null,null,"    3,3",null,null,"  e","        "," 141/150","R,L,P,E,S,T,D"]
[2381,"   S",0.1,null,4," 0.100, 0.100",null,null,"    4,4",null,null,"  e","        "," 141/150","Y,Q,T,A,I,D,V,S"]
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[2391,"   I",-0.291,null,7,"-0.291,-0.291",null,null,"    7,7",null,null,"  b","        "," 144/150","I,L,V"]
[2392,"   L",-0.573,null,9,"-0.573,-0.573",null,null,"    9,9",null,null,"  b","       s"," 144/150","L,F,V"]
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[2417,"   Y",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 144/150","Y"]
[2418,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 144/150","L"]
[2419,"   A",-0.074,null,5,"-0.074,-0.074",null,null,"    5,5",null,null,"  b","        "," 144/150","I,C,T,V,A,S"]
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[2422,"   L",-0.275,null,7,"-0.275,-0.275",null,null,"    7,7",null,null,"  b","        "," 143/150","L,I,V"]
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[2428,"   V",-0.653,null,9,"-0.653,-0.653",null,null,"    9,9",null,null,"  b","       s"," 144/150","K,V"]
[2429,"   R",-0.587,null,9,"-0.587,-0.587",null,null,"    9,9",null,null,"  e","       f"," 144/150","K,Q,R"]
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[2440,"   L",0.695,null,1," 0.695, 0.695",null,null,"    1,1",null,null,"  e","        "," 143/150","S,F,L,P,H,N,K,G,R,E,Q"]
[2441,"   L",1.492,null,1," 1.492, 1.492",null,null,"    1,1",null,null,"  b","        "," 143/150","K,A,N,T,Y,W,S,V,F,C,D,L,M,I,H"]
[2442,"   L",2.199,null,1," 2.199, 2.199",null,null,"    1,1",null,null,"  b","        "," 133/150","S,V,F,L,M,P,I,N,K,T,Q"]
[2443,"   T",1.844,null,1," 1.844, 1.844",null,null,"    1,1",null,null,"  e","        "," 142/150","L,M,P,I,H,V,S,G,E,A,K,N,T"]
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[2445,"   I",0.724,null,1," 0.724, 0.724",null,null,"    1,1",null,null,"  e","        "," 141/150","I,P,M,L,D,F,C,S,V,E,R,T,N,A"]
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[2448,"   E",0.478,null,2," 0.478, 0.478",null,null,"    2,2",null,null,"  e","        "," 142/150","E,Q,G,T,N,I,P,L,D,S,V"]
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[2450,"   V",1.467,null,1," 1.467, 1.467",null,null,"    1,1",null,null,"  e","        "," 142/150","D,F,V,S,I,P,L,M,N,K,Y,E,Q,G,R"]
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[2452,"   M",1.302,null,1," 1.302, 1.302",null,null,"    1,1",null,null,"  b","        "," 140/150","I,P,L,M,F,V,S,W,Y,G,N,K"]
[2453,"   D",1.141,null,1," 1.141, 1.141",null,null,"    1,1",null,null,"  e","        "," 137/150","K,N,A,T,G,Q,E,D,S,I,L,P"]
[2454,"   T",1.733,null,1," 1.733, 1.733",null,null,"    1,1",null,null,"  e","        "," 138/150","G,E,Y,N,A,T,L,P,I,V,S"]
[2455,"   Y",2.922,null,1," 2.922, 2.922",null,null,"    1,1",null,null,"  e","        ","  96/150","Y,G,R,Q,E,N,A,I,L,F,D,S"]
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[2471,"   Q",1.626,null,1," 1.626, 1.626",null,null,"    1,1",null,null,"  e","        "," 107/150","H,I,P,L,S,Q,T,N,A"]
[2472,"   P",1.139,null,1," 1.139, 1.139",null,null,"    1,1",null,null,"  e","        "," 108/150","H,L,P,S,R,Q,A,N,T"]
[2473,"   W",2.374,null,1," 2.374, 2.374",null,null,"    1,1",null,null,"  e","        "," 108/150","G,Q,W,N,A,P,I,H,S,V,C"]
[2474,"   S",1.719,null,1," 1.719, 1.719",null,null,"    1,1",null,null,"  e","        "," 109/150","N,A,T,R,Q,S,V,M,P"]
[2475,"   S",1.388,null,1," 1.388, 1.388",null,null,"    1,1",null,null,"  e","        ","  66/150","S,V,F,M,L,P,G,Q,E"]
[2476,"   P",1.295,null,1," 1.295, 1.295",null,null,"    1,1",null,null,"  e","        ","  66/150","V,S,T,G,Q,E,P"]
[2477,"   K",1.544,null,1," 1.544, 1.544",null,null,"    1,1",null,null,"  e","        ","  70/150","V,S,P,A,N,K,T,R,G,Q"]
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[2482,"   Y",3.142,null,1," 3.142, 3.142",null,null,"    1,1",null,null,"  e","        ","  75/150","L,P,H,S,V,F,Q,Y,N,K,A"]
[2483,"   L",2.672,null,1," 2.672, 2.672",null,null,"    1,1",null,null,"  b","        ","  76/150","T,N,A,Q,G,R,S,V,I,P,L"]
[2484,"   A",2.428,null,1," 2.428, 2.428",null,null,"    1,1",null,null,"  e","        ","  97/150","T,N,A,E,G,S,V,D,P,L,H,I"]
[2485,"   A",2.92,null,1," 2.920, 2.920",null,null,"    1,1",null,null,"  e","        ","  97/150","G,Q,E,Y,N,A,T,L,M,P,I,V,S,C"]
[2486,"   T",4.536,null,1," 4.536, 4.536",null,null,"    1,1",null,null,"  e","        ","  96/150","E,Q,G,Y,T,N,A,K,P,L,H,I,S,V"]
[2487,"   Y",1.529,null,1," 1.529, 1.529",null,null,"    1,1",null,null,"  e","        ","  98/150","Q,Y,N,A,T,P,H,S,V,F"]
[2488,"   P",3.045,null,1," 3.045, 3.045",null,null,"    1,1",null,null,"  e","        "," 133/150","P,F,D,V,S,R,G,Q,E,N,K,A,T"]
[2489,"   T",2.703,null,1," 2.703, 2.703",null,null,"    1,1",null,null,"  e","        "," 138/150","F,S,H,I,P,L,M,T,K,N,A,Q,G,R"]
[2490,"   V",3.27,null,1," 3.270, 3.270",null,null,"    1,1",null,null,"  e","        "," 138/150","T,A,N,Q,G,R,S,V,D,F,P,L,M,H,I"]
[2491,"   G",1.601,null,1," 1.601, 1.601",null,null,"    1,1",null,null,"  e","        "," 139/150","T,K,A,N,Q,G,R,D,C,V,S,H,I,P"]
[2492,"   Q",-0.181,null,6,"-0.181,-0.181",null,null,"    6,6",null,null,"  e","        ","  53/150","A,Q,G"]
[2493,"   T",1.144,null,1," 1.144, 1.144",null,null,"    1,1",null,null,"  e","        ","  53/150","T,V,A,P,L,I"]
[2494,"   S",0.576,null,1," 0.576, 0.576",null,null,"    1,1",null,null,"  e","        "," 139/150","T,A,N,Q,G,F,V,S,I,P,L,M"]
[2495,"   P",2.323,null,1," 2.323, 2.323",null,null,"    1,1",null,null,"  e","        "," 140/150","Q,R,G,T,A,N,P,L,H,S,C"]
[2496,"   R",1.077,null,1," 1.077, 1.077",null,null,"    1,1",null,null,"  e","        "," 137/150","K,A,N,T,G,R,Q,V,S,C,L,M,P,I,H"]
[2497,"   A",0.702,null,1," 0.702, 0.702",null,null,"    1,1",null,null,"  e","        "," 138/150","R,G,N,A,T,P,V,S"]
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[2499,"   K",-0.296,null,7,"-0.296,-0.296",null,null,"    7,7",null,null,"  e","        "," 141/150","R,S,K,T"]
[2500,"   S",-0.489,null,8,"-0.489,-0.489",null,null,"    8,8",null,null,"  e","       f"," 141/150","S,K,H,P,Q"]
[2501,"   M",-0.258,null,7,"-0.258,-0.258",null,null,"    7,7",null,null,"  e","        "," 142/150","I,L,R,M,E,K,T"]
[2502,"   S",-0.478,null,8,"-0.478,-0.478",null,null,"    8,8",null,null,"  e","       f"," 142/150","N,S,T,E,P,Q"]
[2503,"   L",-0.052,null,5,"-0.052,-0.052",null,null,"    5,5",null,null,"  e","        "," 142/150","T,N,Q,V,F,L,M,I"]
[2504,"   D",-0.168,null,6,"-0.168,-0.168",null,null,"    6,6",null,null,"  e","        "," 142/150","F,D,S,N,I,E,P"]
[2505,"   M",0.043,null,5," 0.043, 0.043",null,null,"    5,5",null,null,"  e","        "," 142/150","S,H,L,M,P,A,K,Y,Q,E"]
[2506,"   G",0.569,null,1," 0.569, 0.569",null,null,"    1,1",null,null,"  e","        "," 141/150","C,D,S,M,L,P,N,A,T,G"]
[2507,"   Q",0.12,null,4," 0.120, 0.120",null,null,"    4,4",null,null,"  e","        "," 141/150","Q,T,N,A,P,L,V,S,D"]
[2508,"   P",1.277,null,1," 1.277, 1.277",null,null,"    1,1",null,null,"  e","        "," 141/150","N,A,T,R,Q,S,V,C,F,M,L,P,I"]
[2509,"   S",0.578,null,1," 0.578, 0.578",null,null,"    1,1",null,null,"  e","        "," 142/150","R,Q,A,N,T,I,C,F,S,V"]
[2510,"   Q",0.282,null,3," 0.282, 0.282",null,null,"    3,3",null,null,"  e","        "," 142/150","H,L,P,F,V,S,Y,E,Q,A,K,N,T"]
[2511,"   A",0.081,null,4," 0.081, 0.081",null,null,"    4,4",null,null,"  e","        "," 142/150","Q,G,N,A,L,M,I,S,V"]
[2512,"   N",1.069,null,1," 1.069, 1.069",null,null,"    1,1",null,null,"  e","        "," 142/150","G,R,Q,Y,K,N,M,P,H,S,C"]
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[2514,"   K",0.634,null,1," 0.634, 0.634",null,null,"    1,1",null,null,"  e","        "," 140/150","S,P,M,L,H,T,K,N,Q,R,G"]
[2515,"   K",0.123,null,4," 0.123, 0.123",null,null,"    4,4",null,null,"  e","        "," 137/150","M,R,Q,S,A,K"]
[2516,"   L",0.709,null,1," 0.709, 0.709",null,null,"    1,1",null,null,"  e","        "," 138/150","A,N,K,G,R,Q,E,Y,S,V,F,L,P,H"]
[2517,"   L",1.313,null,1," 1.313, 1.313",null,null,"    1,1",null,null,"  e","        "," 123/150","T,A,K,N,Y,Q,F,V,S,H,I,P,L,M"]
[2518,"   G",1.708,null,1," 1.708, 1.708",null,null,"    1,1",null,null,"  e","        "," 134/150","S,V,F,D,P,I,A,K,T,G,Q,Y"]
[2519,"   T",1.03,null,1," 1.030, 1.030",null,null,"    1,1",null,null,"  e","        "," 122/150","P,M,H,S,V,Q,R,Y,T,N,A"]
[2520,"   R",0.404,null,2," 0.404, 0.404",null,null,"    2,2",null,null,"  e","        ","  89/150","H,L,P,D,Y,R,Q,N,T"]
[2521,"   K",0.753,null,1," 0.753, 0.753",null,null,"    1,1",null,null,"  e","        "," 115/150","Y,Q,T,N,K,H,P,M,L,D,S"]
[2522,"   S",0.042,null,5," 0.042, 0.042",null,null,"    5,5",null,null,"  e","        "," 111/150","K,T,E,Q,D,S,I,P"]
[2523,"   F",1.911,null,1," 1.911, 1.911",null,null,"    1,1",null,null,"  b","        ","  64/150","N,Q,E,V,S,D,F,P,L,H"]
[2524,"   D",1.059,null,1," 1.059, 1.059",null,null,"    1,1",null,null,"  e","        ","  66/150","S,V,D,I,T,E,Q,W"]
[2525,"   H",1.876,null,1," 1.876, 1.876",null,null,"    1,1",null,null,"  e","        ","  67/150","C,F,S,V,I,H,L,P,A,T,G"]
[2526,"   L",1.651,null,1," 1.651, 1.651",null,null,"    1,1",null,null,"  b","        ","  69/150","H,M,L,P,C,D,V,S,N,A,T"]
[2527,"   I",2.544,null,1," 2.544, 2.544",null,null,"    1,1",null,null,"  b","        ","  75/150","N,K,A,E,Q,G,Y,V,S,D,F,P,M,I"]
[2528,"   S",1.245,null,1," 1.245, 1.245",null,null,"    1,1",null,null,"  e","        ","  72/150","I,P,S,E,Q,T,K,X,N"]
[2529,"   D",1.05,null,1," 1.050, 1.050",null,null,"    1,1",null,null,"  e","        "," 107/150","Q,E,G,T,A,N,P,L,M,I,S,D"]
[2530,"   T",1.287,null,1," 1.287, 1.287",null,null,"    1,1",null,null,"  e","        "," 108/150","I,H,L,P,S,V,Y,R,G,E,Q,N,A,T"]
[2531,"   K",0.038,null,5," 0.038, 0.038",null,null,"    5,5",null,null,"  e","        "," 107/150","I,Q,R,V,X,K,S"]
[2532,"   A",1.002,null,1," 1.002, 1.002",null,null,"    1,1",null,null,"  e","        "," 108/150","Q,R,T,N,A,P,M,L,I,S,V"]
[2533,"   P",0.369,null,3," 0.369, 0.369",null,null,"    3,3",null,null,"  e","        "," 108/150","P,L,D,C,S,Q,R,G"]
[2534,"   K",0.279,null,3," 0.279, 0.279",null,null,"    3,3",null,null,"  e","        "," 108/150","K,N,A,Y,W,G,C,F,M,L"]
[2535,"   R",0.707,null,1," 0.707, 0.707",null,null,"    1,1",null,null,"  e","        "," 111/150","K,N,T,R,Y,S,F,D,M,H"]
[2536,"   Q",0.228,null,4," 0.228, 0.228",null,null,"    4,4",null,null,"  e","        "," 112/150","E,Q,G,T,K,A,N,P,M,V,S"]
[2537,"   E",0.128,null,4," 0.128, 0.128",null,null,"    4,4",null,null,"  e","        "," 119/150","Q,E,R,T,N,H,L,D,F,S"]
[2538,"   M",0.032,null,5," 0.032, 0.032",null,null,"    5,5",null,null,"  e","        "," 120/150","H,I,M,V,Q,E,G,R,T,N"]
[2539,"   E",-0.327,null,7,"-0.327,-0.327",null,null,"    7,7",null,null,"  e","        "," 120/150","G,E,Q,N,H,S,F,D"]
[2540,"   S",0.507,null,2," 0.507, 0.507",null,null,"    2,2",null,null,"  e","        "," 120/150","L,S,V,F,D,R,G,Q,N,A"]
[2541,"   G",-0.338,null,7,"-0.338,-0.338",null,null,"    7,7",null,null,"  e","        "," 120/150","Q,G,H,K,A,N,S"]
[2542,"   I",0.551,null,1," 0.551, 0.551",null,null,"    1,1",null,null,"  e","        "," 120/150","I,M,L,P,F,V,S,E,N,A,T"]
[2543,"   T",0.139,null,4," 0.139, 0.139",null,null,"    4,4",null,null,"  e","        "," 119/150","V,L,P,X,N,T,G,R,Q"]
[2544,"   T",0.188,null,4," 0.188, 0.188",null,null,"    4,4",null,null,"  e","        "," 118/150","T,A,N,Q,R,D,F,S,V,I"]
[2545,"   P",1.179,null,1," 1.179, 1.179",null,null,"    1,1",null,null,"  e","        "," 117/150","S,A,N,T,L,Q,P"]
[2546,"   P",0.265,null,3," 0.265, 0.265",null,null,"    3,3",null,null,"  e","        "," 117/150","S,P,H,T,A,K,Q,G,R"]
[2547,"   K",0.957,null,1," 0.957, 0.957",null,null,"    1,1",null,null,"  e","        ","  56/150","V,A,N,S,K,P"]
[2548,"   M",0.801,null,1," 0.801, 0.801",null,null,"    1,1",null,null,"  b","        ","  53/150","N,V,G,M,E"]
[2549,"   R",0.445,null,2," 0.445, 0.445",null,null,"    2,2",null,null,"  e","        ","  55/150","S,D,R,E,H"]
[2550,"   R",0.805,null,1," 0.805, 0.805",null,null,"    1,1",null,null,"  e","        ","  55/150","R,V,T,C,D"]
[2551,"   V",0.486,null,2," 0.486, 0.486",null,null,"    2,2",null,null,"  e","        ","  56/150","D,V,S,L,P"]
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[2553,"   E",0.589,null,1," 0.589, 0.589",null,null,"    1,1",null,null,"  e","        ","  56/150","E,P,S,A,T,F"]
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[2555,"   D",1.29,null,1," 1.290, 1.290",null,null,"    1,1",null,null,"  e","        ","  56/150","E,T,A,N,K,L,D,S"]
[2556,"   Y",0.91,null,1," 0.910, 0.910",null,null,"    1,1",null,null,"  e","        ","  55/150","Y,G,F,N,S"]
[2557,"   E",2.228,null,1," 2.228, 2.228",null,null,"    1,1",null,null,"  e","        ","  56/150","K,A,E,G,S,D,H,I"]
[2558,"   M",2.424,null,1," 2.424, 2.424",null,null,"    1,1",null,null,"  e","        ","  56/150","V,D,C,M,L,I,N,E"]
[2559,"   E",1.799,null,1," 1.799, 1.799",null,null,"    1,1",null,null,"  e","        ","  64/150","E,H,T,V,S,D"]
[2560,"   T",0.976,null,1," 0.976, 0.976",null,null,"    1,1",null,null,"  e","        ","  63/150","S,C,D,P,K,A,N,T,R,Q"]
[2561,"   Q",0.381,null,2," 0.381, 0.381",null,null,"    2,2",null,null,"  e","        ","  63/150","P,Q,L,G,H,Y"]
[2562,"   R",1.415,null,1," 1.415, 1.415",null,null,"    1,1",null,null,"  e","        ","  64/150","T,N,E,Q,R,S,V,F,P,H"]
[2563,"   I",3.125,null,1," 3.125, 3.125",null,null,"    1,1",null,null,"  e","        ","  93/150","D,S,V,I,P,L,M,T,A,K,Q,E,G"]
[2564,"   S",2.56,null,1," 2.560, 2.560",null,null,"    1,1",null,null,"  e","        ","  43/150","P,M,H,I,S,V,D,Q,T,K,A"]
[2565,"   S",1.143,null,1," 1.143, 1.143",null,null,"    1,1",null,null,"  e","        ","  97/150","A,N,K,T,G,E,Q,D,V,S"]
[2566,"   S",3.105,null,1," 3.105, 3.105",null,null,"    1,1",null,null,"  e","        ","  79/150","S,V,D,L,M,P,I,H,N,A,T,R,G,Q,E"]
[2567,"   Q",1.21,null,1," 1.210, 1.210",null,null,"    1,1",null,null,"  e","        ","  83/150","T,N,K,Q,G,R,S,V,C,P,M,I"]
[2568,"   Q",0.936,null,1," 0.936, 0.936",null,null,"    1,1",null,null,"  e","        "," 106/150","Q,G,R,T,A,K,P,L,I,S,D"]
[2569,"   H",0.881,null,1," 0.881, 0.881",null,null,"    1,1",null,null,"  e","        ","  55/150","K,N,D,P,H"]
[2570,"   P",1.16,null,1," 1.160, 1.160",null,null,"    1,1",null,null,"  e","        "," 141/150","H,P,D,S,V,G,R,E,K,N,T"]
[2571,"   H",0.513,null,2," 0.513, 0.513",null,null,"    2,2",null,null,"  e","        "," 140/150","S,D,P,H,N,A,K,T,G,R,Q,E"]
[2572,"   L",0.176,null,4," 0.176, 0.176",null,null,"    4,4",null,null,"  e","        "," 141/150","G,E,Q,K,N,A,T,L,P,C,S"]
[2573,"   R",0.92,null,1," 0.920, 0.920",null,null,"    1,1",null,null,"  e","        "," 141/150","S,V,D,L,I,T,K,A,N,E,R,G"]
[2574,"   K",-0.327,null,7,"-0.327,-0.327",null,null,"    7,7",null,null,"  e","        "," 141/150","R,G,Q,K,A"]
[2575,"   V",0.195,null,4," 0.195, 0.195",null,null,"    4,4",null,null,"  b","        "," 140/150","G,E,A,T,L,S,V,D"]
[2576,"   S",-0.458,null,8,"-0.458,-0.458",null,null,"    8,8",null,null,"  e","       f"," 140/150","F,T,S,A,E,G,R"]
[2577,"   V",-0.008,null,5,"-0.008,-0.008",null,null,"    5,5",null,null,"  e","        "," 141/150","Q,G,T,N,A,I,M,L,V,S"]
[2578,"   S",-0.175,null,6,"-0.175,-0.175",null,null,"    6,6",null,null,"  e","        "," 141/150","T,S,K,N,P,E,G"]
[2579,"   E",-0.196,null,6,"-0.196,-0.196",null,null,"    6,6",null,null,"  e","        "," 141/150","S,D,C,E,Y"]
[2580,"   S",-0.115,null,6,"-0.115,-0.115",null,null,"    6,6",null,null,"  b","        "," 141/150","S,D,C,M,T,N,E,Q,Y"]
[2581,"   N",-0.566,null,9,"-0.566,-0.566",null,null,"    9,9",null,null,"  e","       f"," 141/150","T,S,N,G"]
[2582,"   V",0.069,null,5," 0.069, 0.069",null,null,"    5,5",null,null,"  b","        "," 141/150","A,T,M,L,I,S,V,C"]
[2583,"   L",-0.628,null,9,"-0.628,-0.628",null,null,"    9,9",null,null,"  b","       s"," 141/150","M,L"]
[2584,"   L",-0.568,null,9,"-0.568,-0.568",null,null,"    9,9",null,null,"  b","       s"," 141/150","F,L,I"]
[2585,"   D",-0.524,null,8,"-0.524,-0.524",null,null,"    8,8",null,null,"  e","       f"," 141/150","D,N,E"]
[2586,"   E",-0.136,null,6,"-0.136,-0.136",null,null,"    6,6",null,null,"  e","        "," 141/150","K,S,D,P,E"]
[2587,"   E",0.408,null,2," 0.408, 0.408",null,null,"    2,2",null,null,"  e","        "," 141/150","D,N,S,L,G,Q,E"]
[2588,"   V",-0.347,null,7,"-0.347,-0.347",null,null,"    7,7",null,null,"  b","        "," 141/150","V,M,L,I"]
[2589,"   L",-0.563,null,9,"-0.563,-0.563",null,null,"    9,9",null,null,"  b","       s"," 141/150","V,L"]
[2590,"   T",-0.012,null,5,"-0.012,-0.012",null,null,"    5,5",null,null,"  e","        "," 141/150","C,N,V,S,T,P"]
[2591,"   D",-0.353,null,7,"-0.353,-0.353",null,null,"    7,7",null,null,"  e","        "," 141/150","D,N,E,G"]
[2592,"   P",0.162,null,4," 0.162, 0.162",null,null,"    4,4",null,null,"  e","        "," 141/150","L,P,I,S,V,F,D,E,Y,T"]
[2593,"   K",0.56,null,1," 0.560, 0.560",null,null,"    1,1",null,null,"  e","        "," 141/150","D,S,P,T,A,N,K,Q,G"]
[2594,"   I",-0.169,null,6,"-0.169,-0.169",null,null,"    6,6",null,null,"  b","        "," 141/150","Q,L,I,T,V,N,S"]
[2595,"   Q",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 141/150","Q"]
[2596,"   A",-0.342,null,7,"-0.342,-0.342",null,null,"    7,7",null,null,"  b","        "," 141/150","T,V,K,S,A,I"]
[2597,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 141/150","L"]
[2598,"   L",-0.378,null,7,"-0.378,-0.378",null,null,"    7,7",null,null,"  b","        "," 141/150","V,A,T,L,I"]
[2599,"   L",-0.51,null,8,"-0.510,-0.510",null,null,"    8,8",null,null,"  b","        "," 141/150","I,L,M"]
[2600,"   T",-0.609,null,9,"-0.609,-0.609",null,null,"    9,9",null,null,"  e","       f"," 141/150","A,T,I"]
[2601,"   V",-0.468,null,8,"-0.468,-0.468",null,null,"    8,8",null,null,"  b","        "," 141/150","M,I,T,V"]
[2602,"   L",-0.628,null,9,"-0.628,-0.628",null,null,"    9,9",null,null,"  b","       s"," 141/150","L,M"]
[2603,"   A",-0.462,null,8,"-0.462,-0.462",null,null,"    8,8",null,null,"  b","        "," 141/150","G,V,A,T"]
[2604,"   T",-0.568,null,9,"-0.568,-0.568",null,null,"    9,9",null,null,"  e","       f"," 141/150","I,R,C,T"]
[2605,"   L",-0.267,null,7,"-0.267,-0.267",null,null,"    7,7",null,null,"  b","        "," 141/150","M,L,Q,I"]
[2606,"   V",-0.612,null,9,"-0.612,-0.612",null,null,"    9,9",null,null,"  b","       s"," 140/150","L,V,C"]
[2607,"   K",-0.398,null,8,"-0.398,-0.398",null,null,"    8,8",null,null,"  e","       f"," 139/150","R,E,K"]
[2608,"   Y",-0.093,null,6,"-0.093,-0.093",null,null,"    6,6",null,null,"  e","        "," 139/150","Y,H,F,C,N"]
[2609,"   T",-0.022,null,5,"-0.022,-0.022",null,null,"    5,5",null,null,"  b","        "," 140/150","I,Y,C,T,S,A,N"]
[2610,"   T",-0.148,null,6,"-0.148,-0.148",null,null,"    6,6",null,null,"  e","        "," 140/150","T,S,A,V,M"]
[2611,"   D",-0.238,null,7,"-0.238,-0.238",null,null,"    7,7",null,null,"  e","        "," 140/150","D,S,N,G,E"]
[2612,"   E",-0.203,null,6,"-0.203,-0.203",null,null,"    6,6",null,null,"  e","        "," 140/150","D,E,L,G"]
[2613,"   F",0.5,null,2," 0.500, 0.500",null,null,"    2,2",null,null,"  e","        "," 140/150","D,F,S,V,H,I,T,K,A,N,G"]
[2614,"   D",-0.32,null,7,"-0.320,-0.320",null,null,"    7,7",null,null,"  e","        "," 140/150","E,G,H,I,A,D"]
[2615,"   Q",0.097,null,4," 0.097, 0.097",null,null,"    4,4",null,null,"  b","        "," 140/150","I,L,M,S,V,Q,T,N,A"]
[2616,"   R",-0.408,null,8,"-0.408,-0.408",null,null,"    8,8",null,null,"  e","       f"," 140/150","K,G,R,Q"]
[2617,"   I",-0.166,null,6,"-0.166,-0.166",null,null,"    6,6",null,null,"  b","        "," 140/150","S,V,T,F,I,Y"]
[2618,"   L",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 140/150","L,I"]
[2619,"   Y",-0.621,null,9,"-0.621,-0.621",null,null,"    9,9",null,null,"  b","       s"," 139/150","Y,F"]
[2620,"   E",-0.43,null,8,"-0.430,-0.430",null,null,"    8,8",null,null,"  e","       f"," 139/150","D,Q,E"]
[2621,"   Y",-0.474,null,8,"-0.474,-0.474",null,null,"    8,8",null,null,"  b","        "," 139/150","V,F,Y"]
[2622,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 139/150","L"]
[2623,"   A",-0.6,null,9,"-0.600,-0.600",null,null,"    9,9",null,null,"  e","       f"," 139/150","S,A,T"]
[2624,"   E",-0.512,null,8,"-0.512,-0.512",null,null,"    8,8",null,null,"  e","       f"," 139/150","D,H,E"]
[2625,"   A",-0.497,null,8,"-0.497,-0.497",null,null,"    8,8",null,null,"  b","        "," 140/150","A,K,G"]
[2626,"   S",-0.584,null,9,"-0.584,-0.584",null,null,"    9,9",null,null,"  e","       f"," 140/150","S,A,T,Y"]
[2627,"   V",-0.015,null,5,"-0.015,-0.015",null,null,"    5,5",null,null,"  b","        "," 140/150","T,V,Q,M,L,I"]
[2628,"   V",-0.578,null,9,"-0.578,-0.578",null,null,"    9,9",null,null,"  b","       s"," 140/150","A,V,S"]
[2629,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 140/150","F"]
[2630,"   P",-0.128,null,6,"-0.128,-0.128",null,null,"    6,6",null,null,"  e","        "," 140/150","D,A,S,R,P"]
[2631,"   K",-0.084,null,6,"-0.084,-0.084",null,null,"    6,6",null,null,"  e","        "," 140/150","K,F,Q,R,G"]
[2632,"   V",-0.615,null,9,"-0.615,-0.615",null,null,"    9,9",null,null,"  b","       s"," 140/150","I,V,F"]
[2633,"   F",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 140/150","F"]
[2634,"   P",-0.351,null,7,"-0.351,-0.351",null,null,"    7,7",null,null,"  e","        "," 140/150","S,P,R"]
[2635,"   V",-0.541,null,9,"-0.541,-0.541",null,null,"    9,9",null,null,"  b","       s"," 139/150","V,T,Y,I"]
[2636,"   V",-0.583,null,9,"-0.583,-0.583",null,null,"    9,9",null,null,"  b","       s"," 139/150","V,I"]
[2637,"   H",-0.283,null,7,"-0.283,-0.283",null,null,"    7,7",null,null,"  b","        "," 140/150","H,I,Y,N"]
[2638,"   N",-0.381,null,7,"-0.381,-0.381",null,null,"    7,7",null,null,"  e","        "," 140/150","P,C,T,N,S"]
[2639,"   L",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 140/150","L"]
[2640,"   L",-0.567,null,9,"-0.567,-0.567",null,null,"    9,9",null,null,"  b","       s"," 140/150","L,I"]
[2641,"   D",-0.575,null,9,"-0.575,-0.575",null,null,"    9,9",null,null,"  e","       f"," 140/150","A,D,G"]
[2642,"   S",-0.175,null,6,"-0.175,-0.175",null,null,"    6,6",null,null,"  e","        "," 140/150","F,A,V,S,Q,M,G"]
[2643,"   K",-0.523,null,8,"-0.523,-0.523",null,null,"    8,8",null,null,"  e","       f"," 140/150","D,K,R,Q"]
[2644,"   I",-0.473,null,8,"-0.473,-0.473",null,null,"    8,8",null,null,"  b","        "," 140/150","V,I,M,L"]
[2645,"   N",0.059,null,5," 0.059, 0.059",null,null,"    5,5",null,null,"  e","        "," 140/150","S,N,T,I,Q"]
[2646,"   T",0.272,null,3," 0.272, 0.272",null,null,"    3,3",null,null,"  e","        "," 140/150","A,N,T,Y,Q,S,I,H"]
[2647,"   L",-0.289,null,7,"-0.289,-0.289",null,null,"    7,7",null,null,"  b","        "," 140/150","I,L,V"]
[2648,"   L",-0.503,null,8,"-0.503,-0.503",null,null,"    8,8",null,null,"  b","        "," 140/150","V,L,M"]
[2649,"   S",0.252,null,3," 0.252, 0.252",null,null,"    3,3",null,null,"  b","        "," 140/150","T,A,N,Q,G,R,S,C,L,M"]
[2650,"   L",0.791,null,1," 0.791, 0.791",null,null,"    1,1",null,null,"  b","        "," 140/150","A,N,T,Q,F,V,S,I,H,M,L"]
[2651,"   C",-0.155,null,6,"-0.155,-0.155",null,null,"    6,6",null,null,"  b","        "," 140/150","S,C,G,Y"]
[2652,"   Q",-0.156,null,6,"-0.156,-0.156",null,null,"    6,6",null,null,"  e","        "," 140/150","N,S,D,Q,E,H,Y"]
[2653,"   D",-0.578,null,9,"-0.578,-0.578",null,null,"    9,9",null,null,"  e","       f"," 140/150","D,N"]
[2654,"   P",-0.112,null,6,"-0.112,-0.112",null,null,"    6,6",null,null,"  e","        "," 140/150","I,H,P,V,S,R,Q,K,A,T"]
[2655,"   N",0.634,null,1," 0.634, 0.634",null,null,"    1,1",null,null,"  e","        "," 140/150","T,K,N,A,E,G,V,D,C,L,M,I"]
[2656,"   L",-0.458,null,8,"-0.458,-0.458",null,null,"    8,8",null,null,"  b","        "," 140/150","I,M,L,V,T"]
[2657,"   L",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 140/150","L,V"]
[2658,"   N",0.27,null,3," 0.270, 0.270",null,null,"    3,3",null,null,"  e","        "," 140/150","G,R,T,A,K,S,N"]
[2659,"   P",-0.169,null,6,"-0.169,-0.169",null,null,"    6,6",null,null,"  b","        "," 140/150","A,S,T,P"]
[2660,"   I",-0.465,null,8,"-0.465,-0.465",null,null,"    8,8",null,null,"  b","        "," 140/150","V,I"]
[2661,"   H",-0.485,null,8,"-0.485,-0.485",null,null,"    8,8",null,null,"  b","        "," 140/150","H,Q,R,L"]
[2662,"   G",0.358,null,3," 0.358, 0.358",null,null,"    3,3",null,null,"  b","        "," 140/150","G,T,A,N,H,V,S,C"]
[2663,"   I",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 140/150","I"]
[2664,"   V",-0.55,null,9,"-0.550,-0.550",null,null,"    9,9",null,null,"  b","       s"," 140/150","V,I"]
[2665,"   Q",-0.449,null,8,"-0.449,-0.449",null,null,"    8,8",null,null,"  e","       f"," 140/150","K,N,H,E,Q"]
[2666,"   S",-0.49,null,8,"-0.490,-0.490",null,null,"    8,8",null,null,"  b","        "," 140/150","N,S"]
[2667,"   V",-0.522,null,8,"-0.522,-0.522",null,null,"    8,8",null,null,"  b","        "," 140/150","V,S,T,M,I"]
[2668,"   V",-0.27,null,7,"-0.270,-0.270",null,null,"    7,7",null,null,"  b","        "," 140/150","V,S,L,M,I"]
[2669,"   Y",-0.155,null,6,"-0.155,-0.155",null,null,"    6,6",null,null,"  b","        "," 140/150","Y,T,A,I,P,L,S,V"]
[2670,"   H",0.302,null,3," 0.302, 0.302",null,null,"    3,3",null,null,"  b","        "," 140/150","L,H,V,S,F,C,Y,A,N,T"]
[2671,"   E",-0.435,null,8,"-0.435,-0.435",null,null,"    8,8",null,null,"  e","       f"," 140/150","G,Q,E,K,N"]
[2672,"   E",-0.331,null,7,"-0.331,-0.331",null,null,"    7,7",null,null,"  e","        "," 140/150","D,G,E,Q"]
[2673,"   S",0.566,null,1," 0.566, 0.566",null,null,"    1,1",null,null,"  e","        "," 140/150","P,S,Y,Q,E,G,T,N,A"]
[2674,"   P",0.132,null,4," 0.132, 0.132",null,null,"    4,4",null,null,"  e","        "," 138/150","P,S,C,G,Q,Y,K,A,N,T"]
[2675,"   P",1.299,null,1," 1.299, 1.299",null,null,"    1,1",null,null,"  e","        ","  54/150","G,Q,P,D"]
[2676,"   Q",-0.411,null,8,"-0.411,-0.411",null,null,"    8,8",null,null,"  e","       f"," 132/150","N,V,D,R,L,Q"]
[2677,"   Y",-0.477,null,8,"-0.477,-0.477",null,null,"    8,8",null,null,"  e","       f"," 141/150","Y,P,E,Q,N"]
[2678,"   Q",-0.473,null,8,"-0.473,-0.473",null,null,"    8,8",null,null,"  e","       f"," 140/150","V,S,H,L,P,Q"]
[2679,"   T",-0.053,null,5,"-0.053,-0.053",null,null,"    5,5",null,null,"  e","        "," 139/150","S,T,L,M,P,Q,H"]
[2680,"   S",-0.43,null,8,"-0.430,-0.430",null,null,"    8,8",null,null,"  e","       f"," 139/150","H,S,A,T"]
[2681,"   Y",0.083,null,4," 0.083, 0.083",null,null,"    4,4",null,null,"  b","        "," 140/150","H,Y,R,L,C,F,N"]
[2682,"   L",-0.628,null,9,"-0.628,-0.628",null,null,"    9,9",null,null,"  b","       s"," 140/150","M,L"]
[2683,"   Q",-0.647,null,9,"-0.647,-0.647",null,null,"    9,9",null,null,"  e","       f"," 140/150","Q,S"]
[2684,"   S",-0.403,null,8,"-0.403,-0.403",null,null,"    8,8",null,null,"  e","       f"," 140/150","Q,T,S,N"]
[2685,"   F",0.046,null,5," 0.046, 0.046",null,null,"    5,5",null,null,"  b","        "," 140/150","C,F,S,V,I,M,T,Y"]
[2686,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f"," 140/150","G"]
[2687,"   F",-0.625,null,9,"-0.625,-0.625",null,null,"    9,9",null,null,"  b","       s"," 140/150","N,F"]
[2688,"   N",-0.206,null,6,"-0.206,-0.206",null,null,"    6,6",null,null,"  e","        "," 140/150","S,N,A,Y,G,R"]
[2689,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 140/150","G"]
[2690,"   L",-0.492,null,8,"-0.492,-0.492",null,null,"    8,8",null,null,"  b","        "," 140/150","Y,L,F"]
[2691,"   W",-0.462,null,8,"-0.462,-0.462",null,null,"    8,8",null,null,"  b","        "," 140/150","S,Q,W"]
[2692,"   R",-0.576,null,9,"-0.576,-0.576",null,null,"    9,9",null,null,"  b","       s"," 140/150","G,R,H"]
[2693,"   F",-0.627,null,9,"-0.627,-0.627",null,null,"    9,9",null,null,"  b","       s"," 140/150","F,L"]
[2694,"   A",-0.503,null,8,"-0.503,-0.503",null,null,"    8,8",null,null,"  b","        "," 140/150","T,S,A,K,V"]
[2695,"   G",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  b","       s"," 138/150","G"]
[2696,"   P",0.115,null,4," 0.115, 0.115",null,null,"    4,4",null,null,"  e","        "," 139/150","V,K,T,Y,H,L,P"]
[2697,"   F",-0.438,null,8,"-0.438,-0.438",null,null,"    8,8",null,null,"  e","       f"," 139/150","Y,F"]
[2698,"   S",0.164,null,4," 0.164, 0.164",null,null,"    4,4",null,null,"  e","        "," 139/150","N,K,A,T,E,V,S,P"]
[2699,"   K",-0.356,null,7,"-0.356,-0.356",null,null,"    7,7",null,null,"  e","        "," 138/150","L,E,K,N,T,D"]
[2700,"   Q",-0.155,null,6,"-0.155,-0.155",null,null,"    6,6",null,null,"  e","        ","  55/150","Q,P,K,S"]
[2701,"   T",0.197,null,4," 0.197, 0.197",null,null,"    4,4",null,null,"  e","        "," 139/150","K,N,A,T,R,E,Q,S,L"]
[2702,"   Q",0.432,null,2," 0.432, 0.432",null,null,"    2,2",null,null,"  e","        "," 139/150","Q,G,R,T,A,N,P,M,L,C,S,V"]
[2703,"   I",0.079,null,4," 0.079, 0.079",null,null,"    4,4",null,null,"  e","        "," 139/150","T,N,Q,G,S,F,C,P,M,L,H,I"]
[2704,"   P",0.24,null,3," 0.240, 0.240",null,null,"    3,3",null,null,"  e","        "," 139/150","S,V,P,L,H,N,A,Q,R,G"]
[2705,"   D",-0.243,null,7,"-0.243,-0.243",null,null,"    7,7",null,null,"  e","        "," 139/150","D,N,E,Q"]
[2706,"   Y",0.058,null,5," 0.058, 0.058",null,null,"    5,5",null,null,"  b","        "," 138/150","R,G,Y,I,S,N,T"]
[2707,"   A",-0.167,null,6,"-0.167,-0.167",null,null,"    6,6",null,null,"  b","        "," 139/150","S,V,A,I,G,P"]
[2708,"   E",-0.265,null,7,"-0.265,-0.265",null,null,"    7,7",null,null,"  e","        "," 139/150","P,Q,E,D"]
[2709,"   L",-0.474,null,8,"-0.474,-0.474",null,null,"    8,8",null,null,"  b","        "," 139/150","E,L,H,F"]
[2710,"   I",-0.388,null,8,"-0.388,-0.388",null,null,"    8,8",null,null,"  b","        "," 139/150","F,S,V,I,L"]
[2711,"   V",-0.488,null,8,"-0.488,-0.488",null,null,"    8,8",null,null,"  b","        "," 139/150","T,V,A,L"]
[2712,"   K",-0.406,null,8,"-0.406,-0.406",null,null,"    8,8",null,null,"  e","       f"," 139/150","R,T,K,S,N"]
[2713,"   F",-0.261,null,7,"-0.261,-0.261",null,null,"    7,7",null,null,"  b","        "," 139/150","F,C,A,V,W,Y"]
[2714,"   L",-0.625,null,9,"-0.625,-0.625",null,null,"    9,9",null,null,"  b","       s"," 139/150","L,C"]
[2715,"   D",-0.197,null,6,"-0.197,-0.197",null,null,"    6,6",null,null,"  e","        "," 139/150","D,K,E,R,M"]
[2716,"   A",-0.45,null,8,"-0.450,-0.450",null,null,"    8,8",null,null,"  b","        "," 139/150","T,A,V,L,R,M"]
[2717,"   L",-0.429,null,8,"-0.429,-0.429",null,null,"    8,8",null,null,"  b","        "," 139/150","M,L,I"]
[2718,"   I",-0.517,null,8,"-0.517,-0.517",null,null,"    8,8",null,null,"  b","        "," 139/150","I,V"]
[2719,"   D",-0.309,null,7,"-0.309,-0.309",null,null,"    7,7",null,null,"  e","        "," 139/150","D,K,G,E"]
[2720,"   T",-0.015,null,5,"-0.015,-0.015",null,null,"    5,5",null,null,"  b","        "," 139/150","S,V,I,L,M,T,N,K,R"]
[2721,"   Y",-0.29,null,7,"-0.290,-0.290",null,null,"    7,7",null,null,"  b","        "," 138/150","H,Y,L,C,S"]
[2722,"   L",-0.259,null,7,"-0.259,-0.259",null,null,"    7,7",null,null,"  b","        "," 138/150","V,M,L,P,Y,I,H"]
[2723,"   P",0.817,null,1," 0.817, 0.817",null,null,"    1,1",null,null,"  e","        "," 137/150","S,D,L,M,P,I,H,K,T"]
[2724,"   G",2.398,null,1," 2.398, 2.398",null,null,"    1,1",null,null,"  e","        "," 137/150","I,M,L,D,S,V,G,A,T"]
[2725,"   I",0.727,null,1," 0.727, 0.727",null,null,"    1,1",null,null,"  e","        "," 138/150","E,Q,G,Y,T,A,P,M,I,V,D"]
[2726,"   D",0.169,null,4," 0.169, 0.169",null,null,"    4,4",null,null,"  e","        "," 137/150","D,R,E"]
[2727,"   E",0.918,null,1," 0.918, 0.918",null,null,"    1,1",null,null,"  e","        ","  57/150","R,Q,E,P,D"]
[2728,"   E",3.075,null,1," 3.075, 3.075",null,null,"    1,1",null,null,"  e","        "," 121/150","A,T,L,I,S,F,D,R,G,Q,E,N,K,P,V,C"]
[2729,"   T",1.939,null,1," 1.939, 1.939",null,null,"    1,1",null,null,"  e","        "," 121/150","Q,E,R,G,T,A,I,S,V,D"]
[2730,"   S",3.505,null,1," 3.505, 3.505",null,null,"    1,1",null,null,"  e","        "," 103/150","R,G,Q,E,A,N,T,I,L,M,P,S,V"]
[2731,"   E",1.536,null,1," 1.536, 1.536",null,null,"    1,1",null,null,"  e","        "," 115/150","E,Q,R,G,T,A,N,H,P,L,M,D,F,C,S"]
[2732,"   E",0.424,null,2," 0.424, 0.424",null,null,"    2,2",null,null,"  e","        "," 107/150","D,F,S,Y,Q,E,T,N"]
[2733,"   S",1.661,null,1," 1.661, 1.661",null,null,"    1,1",null,null,"  e","        "," 102/150","N,A,T,Y,G,E,Q,F,C,S,I,H,P"]
[2734,"   L",1.226,null,1," 1.226, 1.226",null,null,"    1,1",null,null,"  e","        "," 104/150","K,N,T,E,Y,S,L,P,I,H"]
[2735,"   L",2.071,null,1," 2.071, 2.071",null,null,"    1,1",null,null,"  e","        ","  63/150","I,H,L,P,F,S,V,R,N"]
[2736,"   T",0.359,null,3," 0.359, 0.359",null,null,"    3,3",null,null,"  e","        ","  56/150","T,A,E,P,H"]
[2737,"   P",1.307,null,1," 1.307, 1.307",null,null,"    1,1",null,null,"  e","        ","  56/150","S,C,P,Y"]
[2738,"   T",0.688,null,1," 0.688, 0.688",null,null,"    1,1",null,null,"  e","        "," 109/150","D,T,I,Y,L,M,E"]
[2739,"   S",2.022,null,1," 2.022, 2.022",null,null,"    1,1",null,null,"  e","        "," 109/150","F,S,V,I,P,L,M,T,N,K,A,E,Q"]
[2740,"   P",1.079,null,1," 1.079, 1.079",null,null,"    1,1",null,null,"  e","        "," 108/150","G,Q,N,A,T,L,P,I,H,V,S"]
[2741,"   Y",0.945,null,1," 0.945, 0.945",null,null,"    1,1",null,null,"  e","        ","  94/150","G,Y,N,T,I,S,V,F,D"]
[2742,"   P",1.701,null,1," 1.701, 1.701",null,null,"    1,1",null,null,"  e","        "," 107/150","R,E,Q,N,A,I,P,D,V,S"]
[2743,"   P",1.104,null,1," 1.104, 1.104",null,null,"    1,1",null,null,"  e","        ","  71/150","S,N,R,G,P"]
[2744,"   A",2.972,null,1," 2.972, 2.972",null,null,"    1,1",null,null,"  e","        ","  86/150","V,S,L,P,N,A,K,T,R,G"]
[2745,"   L",3.521,null,1," 3.521, 3.521",null,null,"    1,1",null,null,"  e","        ","  88/150","D,C,F,S,V,L,M,T,A,N,G"]
[2746,"   Q",-0.099,null,6,"-0.099,-0.099",null,null,"    6,6",null,null,"  e","        "," 129/150","N,Q,R,W,V,S,P,L,I"]
[2747,"   S",0.925,null,1," 0.925, 0.925",null,null,"    1,1",null,null,"  e","        "," 127/150","T,N,A,E,G,S,V,I,P,L,M"]
[2748,"   Q",0.28,null,3," 0.280, 0.280",null,null,"    3,3",null,null,"  e","        ","  55/150","T,H,I,Q,G"]
[2749,"   L",1.148,null,1," 1.148, 1.148",null,null,"    1,1",null,null,"  e","        "," 130/150","G,E,Q,N,T,L,P,I,S,V,C,D"]
[2750,"   S",0.464,null,2," 0.464, 0.464",null,null,"    2,2",null,null,"  e","        "," 130/150","I,P,M,D,C,S,V,Q,G,T,N,A"]
[2751,"   I",0.527,null,2," 0.527, 0.527",null,null,"    2,2",null,null,"  b","        "," 117/150","S,V,D,C,L,I,T,N,K,G,Y"]
[2752,"   T",0.461,null,2," 0.461, 0.461",null,null,"    2,2",null,null,"  e","        "," 119/150","T,N,A,Q,R,G,D,S,V,H,I,P"]
[2753,"   A",-0.063,null,5,"-0.063,-0.063",null,null,"    5,5",null,null,"  b","        "," 132/150","G,R,E,N,A,T,L,H,S,V"]
[2754,"   N",0.281,null,3," 0.281, 0.281",null,null,"    3,3",null,null,"  e","        "," 132/150","G,R,Q,E,Y,N,A,T,P,S,D"]
[2755,"   L",1.117,null,1," 1.117, 1.117",null,null,"    1,1",null,null,"  b","        "," 130/150","I,P,L,M,F,V,S,Y,Q,T,N,K,A"]
[2756,"   N",0.127,null,4," 0.127, 0.127",null,null,"    4,4",null,null,"  e","        "," 131/150","Q,E,R,T,K,A,N,L,V,S,D"]
[2757,"   L",0.782,null,1," 0.782, 0.782",null,null,"    1,1",null,null,"  b","        "," 127/150","K,N,A,T,R,G,E,V,S,C,M,L,I"]
[2758,"   S",0.128,null,4," 0.128, 0.128",null,null,"    4,4",null,null,"  e","        "," 131/150","G,R,Q,A,K,T,I,L,D,S"]
[2759,"   N",-0.045,null,5,"-0.045,-0.045",null,null,"    5,5",null,null,"  e","        "," 131/150","N,K,A,T,Q,S,L,P,I"]
[2760,"   S",-0.205,null,6,"-0.205,-0.205",null,null,"    6,6",null,null,"  e","        "," 131/150","Q,G,R,A,N,K,S"]
[2761,"   M",0.627,null,1," 0.627, 0.627",null,null,"    1,1",null,null,"  b","        "," 130/150","G,T,N,P,M,L,V,S,D,F"]
[2762,"   T",-0.251,null,7,"-0.251,-0.251",null,null,"    7,7",null,null,"  e","        "," 131/150","S,H,P,N,K,T,R,Q"]
[2763,"   S",-0.062,null,5,"-0.062,-0.062",null,null,"    5,5",null,null,"  e","        "," 130/150","F,V,S,M,P,K,A,N,T,R,E"]
[2764,"   L",1.24,null,1," 1.240, 1.240",null,null,"    1,1",null,null,"  e","        "," 124/150","T,G,E,Q,Y,S,V,C,L,M,H"]
[2765,"   A",0.642,null,1," 0.642, 0.642",null,null,"    1,1",null,null,"  b","        "," 123/150","T,N,A,S,G,I"]
[2766,"   T",-0.205,null,6,"-0.205,-0.205",null,null,"    6,6",null,null,"  e","        ","  65/150","S,T,F,G,I"]
[2767,"   S",0.099,null,4," 0.099, 0.099",null,null,"    4,4",null,null,"  e","        ","  64/150","S,V,A,K,L,M"]
[2768,"   Q",-0.185,null,6,"-0.185,-0.185",null,null,"    6,6",null,null,"  e","        ","  64/150","V,H,Q"]
[2769,"   H",0.232,null,3," 0.232, 0.232",null,null,"    3,3",null,null,"  e","        ","  54/150","A,G,R,H"]
[2770,"   S",0.169,null,4," 0.169, 0.169",null,null,"    4,4",null,null,"  e","        "," 117/150","S,V,C,F,L,I,T,N,A,E,Q,G"]
[2771,"   P",-0.686,null,9,"-0.686,-0.686",null,null,"    9,9",null,null,"  e","       f","  51/150","P"]
[2772,"   G",1.096,null,1," 1.096, 1.096",null,null,"    1,1",null,null,"  e","        "," 128/150","G,R,E,A,N,I,L,P,F,D,V"]
[2773,"   I",0.463,null,2," 0.463, 0.463",null,null,"    2,2",null,null,"  e","        "," 128/150","Q,R,G,T,N,K,A,M,L,H,I,V,S,D"]
[2774,"   D",0.822,null,1," 0.822, 0.822",null,null,"    1,1",null,null,"  e","        "," 128/150","M,C,D,S,G,R,E,K,N,A,T"]
[2775,"   K",0.096,null,4," 0.096, 0.096",null,null,"    4,4",null,null,"  e","        "," 113/150","G,E,Q,Y,K,L,P,H,S"]
[2776,"   E",1.585,null,1," 1.585, 1.585",null,null,"    1,1",null,null,"  e","        "," 110/150","Y,G,E,K,A,T,I,F,D,S,V"]
[2777,"   N",0.599,null,1," 0.599, 0.599",null,null,"    1,1",null,null,"  e","        ","  99/150","M,P,H,S,F,R,E,W,A,K,N,T"]
[2778,"   V",1.094,null,1," 1.094, 1.094",null,null,"    1,1",null,null,"  e","        "," 103/150","M,L,P,I,H,V,S,F,R,G,A,K,T"]
[2779,"   E",1.567,null,1," 1.567, 1.567",null,null,"    1,1",null,null,"  e","        ","  81/150","D,V,S,H,L,P,N,A,T,Y,E,Q"]
[2780,"   L",1.633,null,1," 1.633, 1.633",null,null,"    1,1",null,null,"  e","        ","  81/150","T,A,N,K,E,D,S,I,L"]
[2781,"   S",0.752,null,1," 0.752, 0.752",null,null,"    1,1",null,null,"  e","        "," 100/150","C,D,S,V,I,M,P,N,A,T,Y,Q"]
[2782,"   P",2.159,null,1," 2.159, 2.159",null,null,"    1,1",null,null,"  e","        "," 100/150","P,M,L,I,V,S,E,G,R,Y,T,A,K"]
[2783,"   T",0.64,null,1," 0.640, 0.640",null,null,"    1,1",null,null,"  e","        ","  99/150","S,V,D,M,P,H,A,N,T,R,G,E,Q"]
[2784,"   T",2.959,null,1," 2.959, 2.959",null,null,"    1,1",null,null,"  e","        ","  97/150","H,I,P,L,M,F,S,V,E,G,T,N,A"]
[2785,"   G",2.479,null,1," 2.479, 2.479",null,null,"    1,1",null,null,"  e","        ","  94/150","H,I,V,S,D,E,Q,G,Y,T,K,N,A"]
[2786,"   H",2.888,null,1," 2.888, 2.888",null,null,"    1,1",null,null,"  e","        ","  84/150","A,N,T,G,S,V,F,D,L,P,H"]
[2787,"   C",2.52,null,1," 2.520, 2.520",null,null,"    1,1",null,null,"  e","        ","  85/150","G,E,A,N,T,L,V,S,C,F"]
[2788,"   N",1.296,null,1," 1.296, 1.296",null,null,"    1,1",null,null,"  e","        ","  96/150","T,A,N,G,S,F,C,H"]
[2789,"   S",0.654,null,1," 0.654, 0.654",null,null,"    1,1",null,null,"  e","        ","  74/150","E,G,T,A,N,H,C,S"]
[2790,"   G",1.395,null,1," 1.395, 1.395",null,null,"    1,1",null,null,"  e","        ","  87/150","G,R,S,K,C"]
[2791,"   R",0.049,null,5," 0.049, 0.049",null,null,"    5,5",null,null,"  e","        ","  86/150","R,G,M,H,K,N,S"]
[2792,"   T",1.368,null,1," 1.368, 1.368",null,null,"    1,1",null,null,"  e","        "," 108/150","T,A,N,K,E,R,S,V,D,M,H,I"]
[2793,"   R",0.728,null,1," 0.728, 0.728",null,null,"    1,1",null,null,"  e","        "," 107/150","H,P,D,V,S,R,E,N,A,T"]
[2794,"   H",0.174,null,4," 0.174, 0.174",null,null,"    4,4",null,null,"  e","        "," 107/150","D,S,V,H,I,T,A,Q,G"]
[2795,"   G",0.793,null,1," 0.793, 0.793",null,null,"    1,1",null,null,"  b","        "," 105/150","S,V,C,F,G,L,I"]
[2796,"   S",0.545,null,1," 0.545, 0.545",null,null,"    1,1",null,null,"  e","        ","  95/150","N,A,T,R,G,E,S,D,P"]
[2797,"   A",0.124,null,4," 0.124, 0.124",null,null,"    4,4",null,null,"  e","        ","  94/150","N,S,K,A,R,M,Q"]
[2798,"   S",0.46,null,2," 0.460, 0.460",null,null,"    2,2",null,null,"  e","        ","  94/150","A,N,K,G,Q,E,S,V,H"]
[2799,"   Q",0.58,null,1," 0.580, 0.580",null,null,"    1,1",null,null,"  e","        ","  94/150","Q,E,R,S,V,D,F,P,M,L,I"]
[2800,"   V",1.005,null,1," 1.005, 1.005",null,null,"    1,1",null,null,"  e","        ","  91/150","T,G,Q,E,S,V,F,C,P,I,H"]
[2801,"   Q",0.905,null,1," 0.905, 0.905",null,null,"    1,1",null,null,"  e","        ","  90/150","S,V,P,L,I,T,A,N,Q,R,G"]
[2802,"   K",0.037,null,5," 0.037, 0.037",null,null,"    5,5",null,null,"  e","        ","  89/150","H,R,E,D,A,N,K"]
[2803,"   Q",1.002,null,1," 1.002, 1.002",null,null,"    1,1",null,null,"  e","        ","  88/150","N,A,T,E,Q,C,D,V,S"]
[2804,"   R",0.792,null,1," 0.792, 0.792",null,null,"    1,1",null,null,"  e","        ","  95/150","C,D,S,N,K,T,R,E,Q"]
[2805,"   S",0.401,null,2," 0.401, 0.401",null,null,"    2,2",null,null,"  e","        ","  96/150","S,V,R,Q,E,N,K,A"]
[2806,"   A",2.871,null,1," 2.871, 2.871",null,null,"    1,1",null,null,"  e","        ","  96/150","S,V,F,M,L,P,I,K,A,T,G,E"]
[2807,"   G",0.191,null,4," 0.191, 0.191",null,null,"    4,4",null,null,"  e","        ","  93/150","D,K,H,I,E,G"]
[2808,"   S",0.337,null,3," 0.337, 0.337",null,null,"    3,3",null,null,"  e","        ","  90/150","H,D,C,S,E,R,T,K,N"]
[2809,"   F",2.179,null,1," 2.179, 2.179",null,null,"    1,1",null,null,"  e","        ","  81/150","K,N,A,T,G,R,V,F,D,L,M,I"]
[2810,"   K",0.481,null,2," 0.481, 0.481",null,null,"    2,2",null,null,"  e","        ","  80/150","Q,G,T,S,K,D,F"]
[2811,"   R",1.315,null,1," 1.315, 1.315",null,null,"    1,1",null,null,"  e","        ","  78/150","V,H,L,K,T,R,G,Q,E"]
[2812,"   N",1.863,null,1," 1.863, 1.863",null,null,"    1,1",null,null,"  e","        ","  77/150","S,V,D,C,P,M,H,T,A,K,N,G"]
[2813,"   S",0.891,null,1," 0.891, 0.891",null,null,"    1,1",null,null,"  e","        ","  74/150","T,K,A,N,E,G,R,S,D,C"]
[2814,"   I",0.987,null,1," 0.987, 0.987",null,null,"    1,1",null,null,"  e","        ","  71/150","Q,A,K,T,P,I,V,S,D"]
[2815,"   K",0.364,null,3," 0.364, 0.364",null,null,"    3,3",null,null,"  e","        ","  68/150","T,S,N,K,H,R"]
[2816,"   K",0.212,null,4," 0.212, 0.212",null,null,"    4,4",null,null,"  e","        ","  64/150","Y,N,S,K,F"]
[2817,"   I",2.573,null,1," 2.573, 2.573",null,null,"    1,1",null,null,"  e","        ","  64/150","I,H,M,L,P,K,V"]
[2818,"   V",0.289,null,3," 0.289, 0.289",null,null,"    3,3",null,null,"  e","        ","  58/150","L,R,H,V,S"]
[]
[]
["*Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences,"]
["or the confidence interval for the estimated score is equal to- or larger than- 4 color grades."]

{"sheet":"Nf1fl (alt order)","index":16,"n_rows":2820,"n_cols":41,"rows_kept":2250,"cut":true,"merged":[[0,0,0,39]],"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["NF1 full length"]
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[7,"V","L","H",3,6,0,3,0,28,0,20,1,"b","e","b","i",69,4,33,13,14,16,19,20,20,18,16,12,10,null,0.21,"-",0.61,"D",0.28,"-",0.354,5,"-","-"]
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[13,"V","L","H",9,9,0,0,0,0,0,0,9,"b","b","b","b",94,1,4,46,35,16,9,6,3,2,1,0,0,null,0.11,"-",0.24,"-",0.25,"-",0.323,6,"-","-"]
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[1911,"S","L","H",6,8,0,1,0,72,0,56,3,"b","e","b","e",84,2,15,6,7,8,10,14,19,25,27,22,18,null,0.15,"-",0.4,"-",0.4,"-",0.303,7,"-","-"]
[1913,"F","L","H",3,6,0,3,0,0,0,0,3,"b","b","b","b",63,5,33,32,30,25,21,16,11,6,4,3,2,null,0.17,"-",0.45,"-",0.25,"-",0.293,7,"-","-"]
[1914,"S","L","H",1,5,0,4,0,54,0,42,1,"b","e","b","e",58,4,42,11,12,13,15,18,21,23,23,21,19,null,0.13,"-",0.6,"D",0.24,"-",0.313,6,"-","-"]
[1916,"S","L","L",4,2,0,6,0,15,0,12,1,"b","b","b","i",27,6,68,17,19,21,22,21,18,15,13,12,11,null,0.12,"-",0.6,"D",0.4,"-",0.303,7,"-","-"]
[1917,"S","L","L",5,2,0,7,0,54,0,42,2,"b","e","b","e",21,4,78,9,9,10,14,18,22,24,23,20,17,null,0.13,"-",0.72,"D",0.29,"-",0.303,7,"-","-"]
[1919,"E","L","H",0,4,0,4,0,108,0,56,3,"b","e","b","e",49,4,49,6,6,8,11,14,18,22,26,26,26,null,0.15,"-",0.69,"D",0.21,"-",0.3,7,"-","-"]
[1920,"L","L","H",2,5,0,3,0,0,0,0,1,"b","b","b","b",58,5,38,24,23,21,20,19,16,13,10,8,7,null,0.18,"-",0.58,"D",0.2,"-",0.283,7,"-","-"]
[1922,"H","L","H",6,7,0,1,0,36,0,20,1,"b","e","b","i",77,7,17,16,17,18,21,22,22,19,15,10,7,null,0.24,"-",0.46,"-",0.13,"-",0.263,8,"-","-"]
[1923,"L","L","H",6,7,0,1,0,0,0,0,1,"b","b","b","b",77,9,16,25,24,22,21,19,16,13,9,6,4,null,0.24,"-",0.33,"-",0.15,"-",0.26,8,"-","-"]
[1925,"L","L","H",7,8,0,1,0,0,0,0,5,"b","b","b","b",83,6,10,35,30,21,16,13,10,7,5,3,2,null,0.16,"-",0.23,"-",0.14,"-",0.253,8,"-","-"]
[1926,"E","L","H",6,8,0,1,0,0,0,0,1,"b","b","b","b",80,7,13,26,24,22,20,18,16,12,8,5,4,null,0.12,"-",0.34,"-",0.13,"-",0.253,8,"-","-"]
[1929,"T","L","H",4,6,0,2,0,0,0,0,3,"b","b","b","b",70,5,28,29,27,22,19,15,12,8,5,3,2,null,0.07,"-",0.34,"-",0.14,"-",0.27,8,"-","-"]
[1930,"P","L","H",5,7,0,2,0,0,0,0,2,"b","b","b","b",78,5,21,25,23,19,18,17,16,14,11,8,6,null,0.09,"-",0.35,"-",0.14,"-",0.263,8,"-","-"]
[1932,"L","L","H",7,8,0,0,0,0,0,0,6,"b","b","b","b",86,5,10,39,33,21,16,11,7,4,2,1,1,null,0.09,"-",0.34,"-",0.13,"-",0.253,8,"-","-"]
[1933,"S","L","H",7,8,0,1,0,39,0,30,1,"b","e","b","i",85,5,12,17,16,16,19,21,23,21,16,11,7,null,0.09,"-",0.4,"-",0.13,"-",0.263,8,"-","-"]
[1935,"L","L","H",6,8,0,1,0,0,0,0,9,"b","b","b","b",83,6,14,43,34,19,12,8,5,3,1,0,0,null,0.14,"-",0.33,"-",0.14,"-",0.253,8,"-","-"]
[1936,"V","L","H",6,7,1,1,0,0,0,0,0,"b","b","b","b",79,11,15,22,21,20,20,20,18,16,14,11,9,null,0.14,"-",0.43,"-",0.17,"-",0.263,8,"-","-"]
[1938,"F","L","H",1,5,1,3,0,23,0,12,0,"b","b","b","i",53,17,35,19,19,19,20,20,19,15,12,9,7,null,0.24,"-",0.47,"D",0.29,"-",0.293,7,"-","-"]
[1939,"C","L","L",1,3,1,5,0,0,0,0,0,"b","b","b","b",34,16,53,25,24,23,22,20,16,12,8,6,5,null,0.25,"-",0.58,"D",0.25,"-",0.293,7,"-","-"]
[1941,"H","L","L",4,2,0,6,0,55,0,30,1,"b","e","b","i",21,10,70,10,11,15,19,22,23,21,19,17,16,null,0.21,"-",0.7,"D",0.65,"D",0.404,3,"-","-"]
[1942,"N","L","L",5,2,0,7,0,141,0,90,2,"b","e","b","e",21,6,74,6,6,8,10,13,16,20,23,27,29,null,0.26,"-",0.73,"D",0.67,"D",0.434,2,"-","-"]
[1944,"D","L","L",5,2,0,7,0,117,0,72,3,"b","e","b","e",22,5,74,5,6,8,11,14,17,21,24,28,28,null,0.2,"-",0.79,"D",0.88,"D",0.465,1,"-","-"]
[1945,"A","L","L",4,2,0,6,0,31,0,30,0,"b","e","b","i",22,8,69,11,12,14,18,20,21,21,20,18,16,null,0.24,"-",0.79,"D",0.78,"D",0.404,3,"-","-"]
[1947,"R","L","H",2,5,0,3,0,74,0,30,1,"b","e","b","i",61,2,39,12,12,14,18,20,22,22,20,16,13,null,0.22,"-",0.69,"D",0.61,"D",0.354,5,"-","-"]
[1948,"Q","L","H",4,6,0,2,0,110,0,56,2,"b","e","b","e",68,3,28,8,9,10,13,16,19,22,23,21,18,null,0.22,"-",0.66,"D",0.37,"-",0.313,6,"-","-"]
[1950,"V","L","H",7,8,0,1,0,0,0,0,6,"b","b","b","b",87,1,13,37,30,19,15,12,9,6,3,1,1,null,0.2,"-",0.39,"-",0.54,"-",0.293,7,"-","-"]
[1951,"T","L","H",8,9,0,0,0,17,0,12,0,"b","b","b","i",93,1,6,19,19,20,21,21,18,14,10,5,3,null,0.17,"-",0.41,"-",0.28,"-",0.273,8,"-","-"]
[1954,"L","L","H",9,9,0,0,0,0,0,0,9,"b","b","b","b",95,1,3,46,35,16,9,6,3,2,1,0,0,null,0.1,"-",0.26,"-",0.15,"-",0.273,8,"-","-"]
[1955,"D","L","H",9,9,0,0,0,48,0,30,3,"b","e","b","i",94,1,4,11,12,15,19,23,25,22,16,8,4,null,0.08,"-",0.34,"-",0.17,"-",0.283,7,"-","-"]
[1957,"L","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",91,2,7,43,34,19,12,8,4,2,1,0,0,null,0.09,"-",0.24,"-",0.15,"-",0.273,8,"-","-"]
[1958,"I","L","H",7,8,0,0,0,0,0,0,7,"b","b","b","b",89,3,10,38,31,19,14,10,7,5,3,1,0,null,0.09,"-",0.28,"-",0.21,"-",0.273,8,"-","-"]
[1960,"M","L","H",4,6,1,1,0,0,0,0,6,"b","b","b","b",65,18,20,36,30,21,16,12,9,6,3,2,1,null,0.11,"-",0.34,"-",0.37,"-",0.263,8,"-","-"]
[1961,"T","L","H",2,5,2,2,0,0,0,0,6,"b","b","b","b",55,26,24,36,30,20,16,14,11,7,5,3,2,null,0.11,"-",0.32,"-",0.21,"-",0.253,8,"-","-"]
[1963,"N","L","L",0,3,1,4,0,65,0,42,2,"b","e","b","e",39,19,42,12,12,13,16,19,22,23,22,18,16,null,0.09,"-",0.6,"D",0.32,"-",0.28,7,"-","-"]
[1964,"E","L","L",1,3,1,5,0,58,0,30,1,"b","e","b","i",37,13,52,10,11,13,16,20,22,22,20,17,15,null,0.12,"-",0.56,"D",0.35,"-",0.283,7,"-","-"]
[1966,"Q","L","L",3,3,1,5,0,110,0,56,1,"b","e","b","e",31,11,61,10,11,12,15,18,20,22,23,22,20,null,0.12,"-",0.65,"D",0.38,"-",0.323,6,"-","-"]
[1967,"M","L","L",4,2,1,6,0,22,0,12,0,"b","b","b","i",25,12,65,19,19,20,21,20,18,15,13,12,10,null,0.13,"-",0.64,"D",0.49,"-",0.313,6,"-","-"]
[1969,"P","L","H",2,6,0,3,0,40,0,30,2,"b","e","b","i",64,3,36,12,13,14,17,19,21,20,18,14,11,null,0.14,"-",0.49,"D",0.39,"-",0.303,7,"-","-"]
[1970,"S","L","H",6,8,0,1,0,54,0,42,2,"b","e","b","e",83,3,16,8,9,11,14,17,20,22,21,17,14,null,0.13,"-",0.46,"-",0.21,"-",0.293,7,"-","-"]
[1972,"Q","L","H",8,9,0,0,0,0,0,0,4,"b","b","b","b",91,2,7,33,28,19,17,13,10,6,4,2,1,null,0.13,"-",0.38,"-",0.25,"-",0.253,8,"-","-"]
[1973,"A","L","H",9,9,0,0,0,21,0,20,1,"b","e","b","i",94,1,4,15,16,17,20,22,22,19,14,8,4,null,0.16,"-",0.43,"-",0.24,"-",0.27,8,"-","-"]
[1976,"W","L","H",9,9,0,0,0,0,0,0,6,"b","b","b","b",94,2,4,38,32,21,16,11,8,5,3,1,1,null,0.19,"-",0.28,"-",0.21,"-",0.273,8,"-","-"]
[1977,"G","L","H",8,8,0,0,0,0,0,0,1,"b","b","b","b",90,3,8,22,21,19,18,18,17,15,13,9,6,null,0.14,"-",0.4,"-",0.19,"-",0.273,8,"-","-"]
[1979,"L","L","H",5,7,0,2,0,0,0,0,6,"b","b","b","b",76,2,24,36,30,21,16,12,9,6,4,3,2,null,0.09,"-",0.45,"-",0.15,"-",0.26,8,"-","-"]
[1980,"G","L","H",1,5,0,4,0,0,0,0,0,"b","b","b","b",57,4,42,24,23,22,22,20,18,15,12,10,9,null,0.08,"-",0.48,"D",0.14,"-",0.273,8,"-","-"]
[1982,"I","L","L",5,2,0,7,0,20,0,12,1,"b","b","b","i",21,4,75,17,18,20,21,21,18,15,12,10,9,null,0.09,"-",0.65,"D",0.17,"-",0.263,8,"-","-"]
[1983,"T","L","L",5,2,0,7,0,42,0,30,0,"b","e","b","i",24,5,76,13,13,14,17,19,21,21,20,18,16,null,0.12,"-",0.7,"D",0.14,"-",0.263,8,"-","-"]
[1985,"L","L","H",1,5,0,3,0,0,0,0,0,"b","b","b","b",56,8,39,23,23,22,21,20,18,15,11,8,7,null,0.15,"-",0.47,"D",0.16,"-",0.253,8,"-","-"]
[1986,"L","L","H",2,5,0,3,0,0,0,0,3,"b","b","b","b",61,8,33,30,27,21,18,15,12,9,6,3,2,null,0.13,"-",0.39,"-",0.16,"-",0.242,9,"-","-"]
[1988,"V","L","H",7,8,0,1,0,0,0,0,1,"b","b","b","b",82,7,12,25,24,22,21,19,16,11,7,4,2,null,0.13,"-",0.3,"-",0.14,"-",0.25,9,"-","-"]
[1989,"V","L","H",7,8,0,0,0,0,0,0,9,"b","b","b","b",86,6,10,43,34,18,11,8,5,3,1,0,0,null,0.13,"-",0.25,"-",0.15,"-",0.242,9,"-","-"]
[1991,"D","L","H",8,9,0,0,0,32,0,20,2,"b","e","b","i",94,1,5,16,17,19,22,24,24,20,14,7,4,null,0.07,"-",0.36,"-",0.25,"-",0.273,8,"-","-"]
[1992,"S","L","H",8,9,0,0,0,0,0,0,0,"b","b","b","b",94,1,5,22,22,22,22,21,17,12,7,4,2,null,0.09,"-",0.34,"-",0.21,"-",0.273,8,"-","-"]
[1994,"I","L","H",9,9,0,0,0,0,0,0,6,"b","b","b","b",95,2,3,38,32,20,15,11,7,4,2,1,0,null,0.11,"-",0.29,"-",0.31,"-",0.273,8,"-","-"]
[1995,"K","L","H",8,9,0,0,0,61,0,30,2,"b","e","b","i",94,1,5,12,13,15,19,21,24,22,18,11,7,null,0.1,"-",0.4,"-",0.42,"-",0.3,7,"-","-"]
[1998,"A","L","H",4,7,0,2,0,0,0,0,1,"b","b","b","b",72,5,25,26,24,22,20,18,16,13,10,8,7,null,0.18,"-",0.47,"D",0.34,"-",0.293,7,"-","-"]
[1999,"T","L","H",2,5,0,3,0,79,0,56,1,"b","e","b","e",61,7,35,11,12,13,15,17,20,21,22,20,18,null,0.17,"-",0.59,"D",0.33,"-",0.303,7,"-","-"]
[2001,"G","L","L",4,2,0,6,0,47,0,56,3,"b","e","b","e",27,5,72,8,8,9,12,15,19,22,25,25,25,null,0.22,"-",0.68,"D",0.3,"-",0.3,7,"-","-"]
[2002,"L","L","L",5,2,0,7,0,19,0,12,2,"b","b","b","i",21,8,74,15,18,22,24,22,18,14,12,11,11,null,0.22,"-",0.7,"D",0.34,"-",0.273,8,"-","-"]
[2004,"S","L","L",5,2,0,7,0,93,0,72,1,"b","e","b","e",21,9,75,9,10,11,14,16,19,21,22,23,23,null,0.23,"-",0.64,"D",0.21,"-",0.263,8,"-","-"]
[2005,"I","L","L",3,2,1,6,0,33,0,20,1,"b","e","b","i",29,12,62,13,14,17,20,21,21,19,17,15,13,null,0.24,"-",0.59,"D",0.2,"-",0.263,8,"-","-"]
[2007,"A","L","H",3,6,0,2,0,12,0,12,0,"b","b","b","i",63,10,29,22,22,22,23,21,18,14,11,8,6,null,0.21,"-",0.49,"D",0.34,"-",0.283,7,"-","-"]
[2008,"E","L","H",5,7,1,1,0,108,0,56,2,"b","e","b","e",72,11,19,7,8,9,12,16,19,23,24,21,18,null,0.17,"-",0.48,"D",0.33,"-",0.29,7,"-","-"]
[2010,"M","L","H",6,7,1,1,0,0,0,0,6,"b","b","b","b",81,11,13,36,30,21,16,13,9,6,4,3,2,null,0.13,"-",0.34,"-",0.3,"-",0.27,8,"-","-"]
[2011,"A","L","H",6,7,0,1,0,31,0,30,1,"b","e","b","i",82,7,15,17,17,17,19,20,21,19,16,11,8,null,0.09,"-",0.42,"-",0.17,"-",0.273,8,"-","-"]
[2013,"T","L","H",5,7,1,1,0,0,0,0,6,"b","b","b","b",73,14,17,37,30,19,14,11,8,5,3,2,1,null,0.11,"-",0.28,"-",0.15,"-",0.263,8,"-","-"]
[2014,"A","L","H",5,6,1,1,0,0,0,0,7,"b","b","b","b",72,21,14,37,30,18,13,10,7,5,4,2,1,null,0.12,"-",0.27,"-",0.18,"-",0.263,8,"-","-"]
[2016,"A","L","H",4,6,2,1,0,0,0,0,4,"b","b","b","b",68,28,14,32,28,20,17,14,11,8,6,4,3,null,0.1,"-",0.2,"-",0.2,"-",0.263,8,"-","-"]
[2017,"L","L","H",3,5,2,1,0,0,0,0,7,"b","b","b","b",65,30,16,40,33,21,15,11,7,4,3,2,1,null,0.1,"-",0.19,"-",0.22,"-",0.263,8,"-","-"]
[2020,"G","L","L",1,3,1,4,0,0,0,0,1,"b","b","b","b",35,18,50,24,23,21,20,18,15,12,8,6,5,null,0.11,"-",0.37,"-",0.18,"-",0.323,6,"-","-"]
[2021,"N","L","L",3,2,1,5,0,0,0,0,0,"b","b","b","b",27,17,60,20,19,18,18,18,17,15,13,11,9,null,0.12,"-",0.39,"-",0.2,"-",0.323,6,"-","-"]
[2023,"K","L","L",0,4,0,4,0,61,0,30,1,"b","e","b","i",45,9,49,13,13,14,17,19,21,21,19,17,15,null,0.12,"-",0.47,"D",0.31,"-",0.313,6,"-","-"]
[2024,"L","L","H",2,5,1,3,0,49,0,30,1,"b","e","b","i",59,11,32,16,17,17,19,20,21,19,17,15,14,null,0.14,"-",0.56,"D",0.21,"-",0.283,7,"-","-"]
[2026,"S","L","H",4,6,0,2,0,0,0,0,4,"b","b","b","b",69,6,28,31,27,19,17,15,12,9,6,4,3,null,0.11,"-",0.4,"-",0.2,"-",0.263,8,"-","-"]
[2027,"S","L","H",7,8,0,1,0,0,0,0,1,"b","b","b","b",85,3,14,23,21,19,18,18,17,14,11,8,6,null,0.12,"-",0.43,"-",0.2,"-",0.263,8,"-","-"]
[2029,"V","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",94,2,5,43,34,18,12,8,6,4,2,1,0,null,0.17,"-",0.34,"-",0.2,"-",0.253,8,"-","-"]
[2030,"I","L","H",9,9,0,0,0,0,0,0,8,"b","b","b","b",95,1,3,40,32,19,13,9,6,3,2,0,0,null,0.12,"-",0.35,"-",0.19,"-",0.253,8,"-","-"]
[2032,"R","L","H",8,9,0,0,0,49,0,20,4,"b","e","b","i",93,1,6,9,12,17,25,29,29,22,13,5,2,null,0.13,"-",0.42,"-",0.15,"-",0.273,8,"-","-"]
[2033,"M","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",93,1,5,47,35,17,9,6,3,2,1,0,0,null,0.11,"-",0.32,"-",0.15,"-",0.283,7,"-","-"]
[2035,"K","L","H",8,8,0,0,0,114,0,56,4,"b","e","b","e",91,2,9,4,4,6,8,13,19,26,29,25,20,null,0.18,"-",0.46,"-",0.19,"-",0.323,6,"-","-"]
[2036,"I","L","H",6,7,0,1,0,20,0,12,0,"b","b","b","i",81,3,20,19,19,21,22,22,19,14,9,6,4,null,0.22,"-",0.5,"D",0.15,"-",0.323,6,"-","-"]
[2038,"D","L","L",0,4,0,4,0,68,0,42,3,"b","e","b","e",48,6,53,8,9,11,14,17,22,25,24,19,15,null,0.25,"-",0.58,"D",0.19,"-",0.354,5,"-","-"]
[2039,"K","L","L",2,3,0,5,0,114,0,56,2,"b","e","b","e",38,7,58,7,8,10,14,17,21,23,24,22,20,null,0.29,"-",0.67,"D",0.26,"-",0.394,4,"-","-"]
[2042,"L","L","L",6,0,1,7,0,19,0,12,0,"b","b","b","i",10,14,77,20,21,22,23,21,17,13,11,11,10,null,0.49,"-",0.59,"D",0.27,"-",0.364,5,"-","-"]
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[2747,"S","L","L",3,2,1,5,0,0,0,0,2,"b","b","b","b",28,18,64,27,25,22,20,17,14,11,8,7,6,null,0.52,"D",0.47,"D",0.37,"-",0.51,0,"-","-"]
[2748,"Q","L","L",2,3,1,5,0,23,0,12,0,"b","b","b","i",36,19,57,18,18,19,21,21,21,18,15,12,11,null,0.62,"D",0.53,"D",0.36,"-",0.49,1,"-","-"]
[2749,"L","L","L",2,2,1,5,0,0,0,0,0,"b","b","b","b",30,21,56,22,22,21,21,20,18,15,12,10,8,null,0.63,"D",0.47,"D",0.28,"-",0.475,1,"-","-"]
[2750,"S","L","L",2,2,2,5,0,0,0,0,0,"b","b","b","b",29,24,56,23,22,20,20,19,18,15,13,11,9,null,0.58,"D",0.48,"D",0.4,"-",0.465,1,"-","-"]
[2751,"I","L","L",2,2,2,4,0,0,0,0,0,"b","b","b","b",29,28,52,23,23,22,22,20,17,14,11,9,8,null,0.61,"D",0.51,"D",0.28,"-",0.475,1,"-","-"]
[2752,"T","L","L",1,2,3,4,0,42,0,30,1,"b","e","b","i",26,36,46,15,15,16,18,20,21,20,19,16,15,null,0.59,"D",0.55,"D",0.28,"-",0.48,1,"-","-"]
[2753,"A","L","L",2,2,2,5,0,12,0,12,0,"b","b","b","i",23,29,54,19,19,20,21,21,20,18,15,13,12,null,0.55,"D",0.47,"D",0.27,"-",0.475,1,"-","-"]
[2754,"N","L","L",3,1,2,5,0,47,0,30,0,"b","e","b","i",21,25,61,13,13,14,16,18,20,20,20,20,19,null,0.47,"-",0.55,"D",0.38,"-",0.5,0,"-","-"]
[2755,"L","L","L",4,1,2,6,0,19,0,12,1,"b","b","b","i",19,22,64,17,18,19,22,22,21,18,15,13,12,null,0.45,"-",0.55,"D",0.28,"-",0.48,1,"-","-"]
[2756,"N","L","L",4,2,1,6,0,47,0,30,0,"b","e","b","i",21,19,65,15,15,16,18,20,21,21,20,19,17,null,0.48,"-",0.55,"D",0.36,"-",0.525,0,"D","-"]
[2757,"L","L","L",4,2,1,6,0,0,0,0,0,"b","b","b","b",24,19,66,21,21,21,21,20,19,16,13,11,9,null,0.49,"-",0.49,"D",0.39,"-",0.505,0,"-","-"]
[2758,"S","L","L",4,2,1,6,0,15,0,12,0,"b","b","b","i",23,18,67,20,20,20,21,20,19,17,15,13,11,null,0.49,"-",0.56,"D",0.3,"-",0.525,0,"D","-"]
[2759,"N","L","L",3,2,1,6,0,47,0,30,0,"b","e","b","i",26,17,65,17,17,17,19,20,21,20,20,19,18,null,0.55,"D",0.53,"D",0.28,"-",0.545,1,"D","-"]
[2760,"S","L","L",4,2,1,6,0,15,0,12,0,"b","b","b","i",25,17,66,21,21,21,22,21,19,16,13,11,9,null,0.64,"D",0.49,"D",0.36,"-",0.541,0,"D","-"]
[2761,"M","L","L",3,2,2,5,0,0,0,0,0,"b","b","b","b",26,23,59,24,23,21,21,19,17,14,11,9,8,null,0.66,"D",0.48,"D",0.37,"-",0.566,1,"D","-"]
[2762,"T","L","L",3,2,2,5,0,0,0,0,0,"b","b","b","b",24,24,61,22,22,20,21,20,18,16,13,10,9,null,0.72,"D",0.46,"-",0.53,"-",0.556,1,"D","-"]
[2763,"S","L","L",3,2,2,5,0,0,0,0,1,"b","b","b","b",24,26,58,26,25,22,21,18,16,13,10,8,7,null,0.75,"D",0.41,"-",0.47,"-",0.551,1,"D","-"]
[2764,"L","L","L",3,1,2,5,0,0,0,0,0,"b","b","b","b",21,27,60,22,22,21,22,20,18,15,12,10,8,null,0.77,"D",0.45,"-",0.48,"-",0.566,1,"D","-"]
[2765,"A","L","L",3,2,2,5,0,0,0,0,0,"b","b","b","b",21,25,59,20,20,19,20,20,20,18,17,14,13,null,0.72,"D",0.49,"D",0.49,"-",0.561,1,"D","-"]
[2766,"T","L","L",3,2,2,5,0,0,0,0,0,"b","b","b","b",25,23,58,22,21,21,21,20,18,16,13,11,10,null,0.71,"D",0.52,"D",0.58,"D",0.602,3,"D","-"]
[2767,"S","L","L",3,2,1,5,0,26,0,20,0,"b","e","b","i",25,19,62,17,17,17,19,21,21,20,18,16,15,null,0.68,"D",0.53,"D",0.47,"-",0.616,4,"D","-"]
[2768,"Q","L","L",4,1,1,6,0,83,0,42,1,"b","e","b","e",21,16,69,12,13,14,17,19,21,22,21,19,18,null,0.7,"D",0.6,"D",0.51,"-",0.636,4,"D","-"]
[2769,"H","L","L",6,1,1,7,0,22,0,12,0,"b","b","b","i",13,13,77,16,17,19,21,21,20,18,16,15,14,null,0.72,"D",0.57,"D",0.78,"D",0.636,4,"D","-"]
[2770,"S","L","L",7,0,1,8,0,39,0,30,1,"b","e","b","i",8,11,83,13,14,16,19,21,22,21,19,17,16,null,0.69,"D",0.57,"D",0.86,"D",0.636,4,"D","-"]
[2771,"P","L","L",6,1,0,7,0,97,0,72,0,"b","e","b","e",14,10,80,11,12,14,17,19,20,20,20,21,20,null,0.7,"D",0.61,"D",0.87,"D",0.643,5,"D","-"]
[2772,"G","L","L",5,2,0,6,0,60,0,72,1,"b","e","b","e",22,10,74,10,10,11,14,16,18,20,22,24,24,null,0.68,"D",0.62,"D",0.8,"D",0.643,5,"D","-"]
[2773,"I","L","L",4,2,1,6,0,20,0,12,2,"b","b","b","i",24,14,68,17,19,22,24,22,19,15,12,11,11,null,0.65,"D",0.66,"D",0.83,"D",0.626,4,"D","-"]
[2774,"D","L","L",4,2,1,6,0,68,0,42,1,"b","e","b","e",25,13,68,11,11,13,16,19,22,23,22,21,19,null,0.72,"D",0.71,"D",0.75,"D",0.633,4,"D","-"]
[2775,"K","L","L",3,2,1,6,0,147,0,72,1,"b","e","b","e",30,12,65,6,7,9,13,16,19,21,23,24,24,null,0.71,"D",0.73,"D",0.75,"D",0.633,4,"D","-"]
[2776,"E","L","L",4,2,1,6,0,139,0,72,2,"b","e","b","e",25,11,69,6,6,8,12,15,18,21,23,25,25,null,0.71,"D",0.68,"D",0.75,"D",0.626,4,"D","-"]
[2777,"N","L","L",5,1,1,6,0,65,0,42,0,"b","e","b","e",19,12,72,9,10,12,15,18,21,22,22,21,19,null,0.67,"D",0.66,"D",0.77,"D",0.626,4,"D","-"]
[2778,"V","L","L",5,1,1,6,0,28,0,20,1,"b","e","b","i",20,15,71,15,16,18,20,21,21,18,16,13,12,null,0.67,"D",0.62,"D",0.86,"D",0.586,2,"D","-"]
[2779,"E","L","L",5,1,1,6,0,81,0,42,1,"b","e","b","e",18,17,70,11,12,14,17,20,21,22,21,19,18,null,0.63,"D",0.59,"D",0.79,"D",0.596,3,"D","-"]
[2780,"L","L","L",4,1,1,6,0,68,0,42,0,"b","e","b","e",19,17,67,13,13,14,16,18,20,21,20,20,20,null,0.63,"D",0.53,"D",0.64,"D",0.582,2,"D","-"]
[2781,"S","L","L",5,0,1,7,0,15,0,12,0,"b","b","b","i",10,18,77,21,21,21,22,21,19,16,13,11,9,null,0.63,"D",0.51,"D",0.44,"-",0.571,2,"D","-"]
[2782,"P","L","L",5,1,1,7,0,16,0,12,0,"b","b","b","i",12,17,75,20,20,20,21,20,20,19,17,15,14,null,0.63,"D",0.52,"D",0.44,"-",0.606,3,"D","-"]
[2783,"T","L","L",6,0,1,7,0,0,0,0,0,"b","b","b","b",10,14,78,22,21,20,21,20,19,17,15,12,11,null,0.62,"D",0.46,"-",0.54,"-",0.592,2,"D","-"]
[2784,"T","L","L",5,1,1,6,0,0,0,0,0,"b","b","b","b",18,14,71,21,20,20,21,20,19,17,15,13,12,null,0.67,"D",0.5,"D",0.44,"-",0.586,2,"D","-"]
[2785,"G","L","L",4,2,1,6,0,25,0,30,0,"b","e","b","i",23,13,69,14,14,15,17,19,21,21,20,20,19,null,0.71,"D",0.52,"D",0.6,"D",0.616,4,"D","-"]
[2786,"H","L","L",4,2,1,6,0,55,0,30,1,"b","e","b","i",26,16,66,13,14,16,19,22,23,22,19,17,16,null,0.71,"D",0.53,"D",0.57,"-",0.596,3,"D","-"]
[2787,"C","L","L",5,1,1,6,0,27,0,20,1,"b","e","b","i",20,15,70,15,15,17,19,21,21,19,17,16,16,null,0.72,"D",0.48,"D",0.57,"-",0.586,2,"D","-"]
[2788,"N","L","L",6,1,1,7,0,141,0,90,2,"b","e","b","e",15,11,77,8,8,10,12,15,17,19,21,25,27,null,0.69,"D",0.47,"D",0.55,"-",0.602,3,"D","P"]
[2789,"S","L","L",6,1,1,7,0,93,0,72,0,"b","e","b","e",12,11,80,11,12,13,15,17,19,20,20,22,22,null,0.63,"D",0.51,"D",0.52,"-",0.616,4,"D","P"]
[2790,"G","L","L",6,1,1,7,0,25,0,30,0,"b","e","b","i",12,14,77,13,13,15,18,20,21,20,19,18,17,null,0.46,"-",0.41,"-",0.57,"-",0.592,2,"D","-"]
[2791,"R","L","L",4,1,2,6,0,49,0,20,1,"b","e","b","i",13,24,67,14,15,17,20,22,22,20,18,15,13,null,0.46,"-",0.52,"D",0.59,"D",0.606,3,"D","-"]
[2792,"T","L","L",3,1,2,6,0,28,0,20,0,"b","e","b","i",16,25,63,18,18,18,20,21,21,19,17,14,12,null,0.53,"D",0.47,"D",0.74,"D",0.622,4,"D","-"]
[2793,"R","L","L",3,1,2,5,0,29,0,12,0,"b","b","b","i",16,29,60,19,20,21,22,21,20,16,13,9,8,null,0.52,"D",0.39,"-",0.76,"D",0.633,4,"D","-"]
[2794,"H","L","L",4,1,2,6,0,0,0,0,0,"b","b","b","b",16,24,66,22,21,21,21,20,19,16,13,11,9,null,0.57,"D",0.42,"-",0.66,"D",0.626,4,"D","-"]
[2795,"G","L","L",4,2,1,6,0,10,0,12,0,"b","b","b","i",22,18,69,20,20,20,21,21,20,18,16,14,12,null,0.6,"D",0.49,"D",0.73,"D",0.646,5,"D","-"]
[2796,"S","L","L",4,2,1,6,0,0,0,0,0,"b","b","b","b",27,16,67,22,21,20,20,20,19,18,16,14,12,null,0.66,"D",0.46,"-",0.83,"D",0.646,5,"D","-"]
[2797,"A","L","L",1,3,1,5,0,0,0,0,0,"b","b","b","b",43,13,56,24,22,20,21,20,19,17,15,14,13,null,0.71,"D",0.41,"-",0.87,"D",0.646,5,"D","-"]
[2798,"S","L","L",1,3,1,5,0,39,0,30,0,"b","e","b","i",42,11,57,13,14,15,18,20,21,21,21,20,19,null,0.68,"D",0.57,"D",0.87,"D",0.653,5,"D","-"]
[2799,"Q","L","L",1,3,1,5,0,83,0,42,0,"b","e","b","e",39,13,55,8,10,12,16,19,22,23,23,22,20,null,0.67,"D",0.66,"D",0.9,"D",0.653,5,"D","-"]
[2800,"V","L","L",2,3,1,5,0,28,0,20,1,"b","e","b","i",34,17,56,16,16,17,19,21,21,19,17,16,15,null,0.68,"D",0.62,"D",0.91,"D",0.636,4,"D","-"]
[2801,"Q","L","L",4,2,1,5,0,83,0,42,1,"b","e","b","e",24,21,64,12,12,14,17,20,21,22,20,18,17,null,0.68,"D",0.69,"D",0.88,"D",0.643,5,"D","-"]
[2802,"K","L","L",5,1,1,6,0,147,0,72,2,"b","e","b","e",19,18,71,7,8,10,13,16,20,23,26,27,26,null,0.67,"D",0.67,"D",0.9,"D",0.646,5,"D","-"]
[2803,"Q","L","L",5,1,1,6,0,110,0,56,1,"b","e","b","e",16,16,74,7,8,11,15,19,21,22,23,22,21,null,0.59,"D",0.61,"D",0.79,"D",0.643,5,"D","-"]
[2804,"R","L","L",5,1,1,6,0,138,0,56,1,"b","e","b","e",19,16,72,9,9,11,15,18,21,23,24,23,22,null,0.6,"D",0.64,"D",0.87,"D",0.667,6,"D","-"]
[2805,"S","L","L",5,1,1,6,0,26,0,20,0,"b","e","b","i",19,13,73,17,17,18,20,21,20,19,18,17,17,null,0.62,"D",0.59,"D",0.93,"D",0.667,6,"D","-"]
[2806,"A","L","L",4,2,1,6,0,31,0,30,0,"b","e","b","i",27,12,68,13,13,14,18,19,21,21,20,21,20,null,0.62,"D",0.61,"D",0.92,"D",0.667,6,"D","-"]
[2807,"G","L","L",4,2,1,6,0,25,0,30,0,"b","e","b","i",27,13,67,15,15,16,19,20,22,22,21,20,18,null,0.6,"D",0.53,"D",0.85,"D",0.667,6,"D","-"]
[2808,"S","L","L",3,2,1,5,0,0,0,0,0,"b","b","b","b",31,14,65,21,20,19,20,20,20,18,17,15,14,null,0.59,"D",0.53,"D",0.73,"D",0.657,5,"D","-"]
[2809,"F","L","L",2,2,2,4,0,0,0,0,0,"b","b","b","b",32,23,53,25,25,23,22,19,16,12,10,9,8,null,0.7,"D",0.6,"D",0.83,"D",0.657,5,"D","-"]
[2810,"K","L","L",2,2,1,5,0,86,0,42,1,"b","e","b","e",31,19,58,8,8,10,14,17,21,24,24,22,20,null,0.61,"D",0.58,"D",0.91,"D",0.657,5,"D","-"]
[2811,"R","L","L",1,3,1,5,0,74,0,30,1,"b","e","b","i",39,14,55,7,9,13,18,21,23,23,21,18,16,null,0.72,"D",0.63,"D",0.86,"D",0.657,5,"D","-"]
[2812,"N","L","L",0,4,0,4,0,113,0,72,1,"b","e","b","e",46,11,55,6,7,9,13,16,19,21,23,25,25,null,0.37,"-",0.72,"D",0.83,"D",0.657,5,"D","-"]
[2813,"S","L","L",0,4,1,4,0,72,0,56,1,"b","e","b","e",55,14,47,9,10,12,16,18,20,22,23,23,22,null,0.29,"-",0.58,"D",0.8,"D",0.653,5,"D","-"]
[2814,"I","L","L",0,4,1,4,0,50,0,30,0,"b","e","b","i",54,15,47,14,14,15,17,19,20,20,19,19,18,null,0.43,"-",0.58,"D",0.91,"D",0.646,5,"D","-"]
[2815,"K","L","L",0,3,1,4,0,147,0,72,3,"b","e","b","e",44,18,51,2,2,5,8,13,17,23,26,28,28,null,0.3,"-",0.7,"D",0.81,"D",0.657,5,"D","-"]
[2816,"K","L","L",2,2,2,4,0,147,0,72,2,"b","e","b","e",33,25,54,5,5,7,10,14,18,22,25,27,27,null,0.35,"-",0.8,"D",0.77,"D",0.582,2,"D","-"]
[2817,"I","L","L",4,1,2,6,0,20,0,12,1,"b","b","b","i",18,22,64,16,17,18,21,20,18,15,13,13,13,null,0.35,"-",0.77,"D",0.77,"D",0.582,2,"D","-"]
[2818,"V","L","L",8,0,0,8,0,127,0,90,3,"b","e","b","e",3,8,90,7,7,7,9,11,13,15,17,25,28,null,0.38,"-",0.84,"D",0.74,"D",0.545,1,"D","-"]

{"sheet":"E9","index":17,"n_rows":60,"n_cols":40,"rows_kept":60,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
[297,"K","L","H",5,7,0,1,0,86,0,42,2,"b","e","b","e",78,3,20,8,8,11,14,17,20,22,22,18,15,null,0.23,"-",0.56,"D",0.24,"-",0.424,3,"-"]
[298,"L","L","H",7,8,0,1,0,68,0,42,1,"b","e","b","e",83,5,13,10,11,13,16,19,21,22,18,12,7,null,0.21,"-",0.5,"D",0.24,"-",0.384,4,"-"]
[299,"F","L","H",8,8,0,0,0,0,0,0,6,"b","b","b","b",89,4,8,37,31,22,17,14,10,6,3,2,1,null,0.18,"-",0.38,"-",0.44,"-",0.354,5,"-"]
[300,"L","L","H",9,9,0,0,0,0,0,0,3,"b","b","b","b",95,1,3,31,28,23,20,17,12,7,4,2,1,null,0.13,"-",0.42,"-",0.39,"-",0.333,6,"-"]
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[308,"A","L","H",0,4,0,4,0,59,0,56,3,"b","e","b","e",51,6,49,7,8,10,13,16,20,24,26,24,22,null,0.27,"-",0.66,"D",0.44,"-",0.333,6,"-"]
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[310,"H","L","L",4,2,0,6,0,55,0,30,0,"b","e","b","i",26,6,71,8,10,13,17,21,23,22,21,20,19,null,0.3,"-",0.61,"D",0.24,"-",0.323,6,"-"]
[311,"G","L","L",5,1,0,7,0,75,0,90,2,"b","e","b","e",18,9,77,7,7,9,12,14,17,19,22,26,28,null,0.28,"-",0.66,"D",0.25,"-",0.343,5,"-"]
[312,"G","L","L",5,2,0,7,0,75,0,90,3,"b","e","b","e",20,9,71,6,7,8,11,14,16,19,21,27,29,null,0.24,"-",0.68,"D",0.43,"-",0.354,5,"-"]
[313,"S","L","L",4,2,0,6,0,117,0,90,2,"b","e","b","e",25,8,70,9,9,10,13,15,17,19,20,24,26,null,0.21,"-",0.65,"D",0.49,"-",0.354,5,"-"]
[314,"R","L","L",4,2,1,6,0,74,0,30,0,"b","e","b","i",24,11,66,10,11,14,18,20,21,21,20,19,18,null,0.23,"-",0.72,"D",0.48,"-",0.313,6,"-"]
[315,"Q","L","L",3,2,1,6,0,59,0,30,2,"b","e","b","i",30,11,62,12,13,15,19,21,23,21,18,14,11,null,0.27,"-",0.68,"D",0.48,"-",0.303,7,"-"]
[316,"L","L","L",0,4,1,4,0,0,0,0,0,"b","b","b","b",44,11,47,23,23,23,23,21,18,13,10,6,5,null,0.27,"-",0.57,"D",0.36,"-",0.293,7,"-"]
[317,"T","L","H",1,5,0,3,0,0,0,0,0,"b","b","b","b",56,9,40,24,23,21,21,19,17,14,10,7,5,null,0.27,"-",0.46,"-",0.35,"-",0.27,8,"-"]
[318,"E","L","H",4,6,0,2,0,0,0,0,1,"b","b","b","b",70,7,28,26,25,22,21,18,16,12,8,5,4,null,0.22,"-",0.42,"-",0.23,"-",0.253,8,"-"]
[319,"S","L","H",6,7,0,1,0,0,0,0,3,"b","b","b","b",79,8,15,32,28,21,19,15,12,8,5,3,2,null,0.24,"-",0.34,"-",0.17,"-",0.253,8,"-"]
[320,"A","L","H",6,7,1,1,0,0,0,0,9,"b","b","b","b",79,11,12,42,33,17,12,8,6,4,2,1,1,null,0.18,"-",0.18,"-",0.2,"-",0.26,8,"-"]
[321,"A","L","H",6,7,1,0,0,0,0,0,8,"b","b","b","b",80,14,8,40,32,17,12,8,6,4,2,1,1,null,0.15,"-",0.16,"-",0.2,"-",0.253,8,"-"]
[322,"I","L","H",6,7,1,0,0,0,0,0,4,"b","b","b","b",79,17,8,33,29,22,18,14,10,6,3,1,1,null,0.13,"-",0.17,"-",0.16,"-",0.253,8,"-"]
[323,"A","L","H",5,7,1,0,0,0,0,0,9,"b","b","b","b",74,20,10,43,35,18,12,8,5,3,1,0,0,null,0.11,"-",0.14,"-",0.17,"-",0.253,8,"-"]
[324,"C","L","H",6,7,1,0,0,0,0,0,7,"b","b","b","b",81,13,8,40,33,20,14,10,7,4,2,1,0,null,0.09,"-",0.14,"-",0.15,"-",0.253,8,"-"]
[325,"V","L","H",6,7,1,0,0,0,0,0,8,"b","b","b","b",82,13,8,40,32,18,12,9,6,3,2,1,0,null,0.07,"-",0.28,"-",0.16,"-",0.253,8,"-"]
[326,"K","L","H",6,7,0,1,0,0,0,0,2,"b","b","b","b",82,9,13,27,25,21,20,18,15,11,7,4,2,null,0.06,"-",0.26,"-",0.17,"-",0.273,8,"-"]
[327,"L","L","H",7,8,0,0,0,0,0,0,9,"b","b","b","b",85,7,10,42,33,18,11,7,5,3,2,1,1,null,0.08,"-",0.2,"-",0.17,"-",0.273,8,"-"]
[328,"C","L","H",6,7,0,1,0,0,0,0,6,"b","b","b","b",78,9,15,37,31,21,15,11,7,4,2,1,1,null,0.1,"-",0.28,"-",0.15,"-",0.273,8,"-"]
[329,"K","L","H",5,7,1,1,0,41,0,20,1,"b","e","b","i",76,11,17,19,19,20,23,24,23,18,13,7,5,null,0.1,"-",0.29,"-",0.2,"-",0.273,8,"-"]
[330,"A","L","H",3,6,0,2,0,0,0,0,6,"b","b","b","b",65,10,28,34,29,18,14,11,9,7,6,5,4,null,0.14,"-",0.31,"-",0.19,"-",0.273,8,"-"]
[331,"S","L","H",3,6,1,2,0,0,0,0,5,"b","b","b","b",65,14,28,35,29,20,16,14,11,9,7,6,5,null,0.16,"-",0.27,"-",0.17,"-",0.283,7,"-"]
[332,"T","L","H",2,5,1,3,0,0,0,0,1,"b","b","b","b",54,18,34,22,20,18,18,18,18,18,17,15,13,null,0.2,"-",0.34,"-",0.28,"-",0.283,7,"-"]
[333,"Y","L","H",0,4,2,3,0,26,0,12,0,"b","b","b","i",47,23,39,19,19,19,20,20,19,16,13,11,9,null,0.18,"-",0.4,"-",0.42,"-",0.283,7,"-"]
[334,"I","L","L",2,2,2,4,0,0,0,0,1,"b","b","b","b",23,31,51,27,26,23,21,18,13,9,6,5,4,null,0.16,"-",0.45,"-",0.33,"-",0.263,8,"-"]
[335,"N","L","L",5,1,1,6,0,47,0,30,1,"b","e","b","i",17,18,68,11,12,13,16,19,21,21,20,17,15,null,0.15,"-",0.55,"D",0.28,"-",0.253,8,"-"]
[336,"W","L","L",4,2,1,6,0,68,0,30,0,"b","e","b","i",22,15,66,13,14,15,18,20,21,20,19,18,18,null,0.16,"-",0.66,"D",0.2,"-",0.253,8,"-"]
[337,"E","L","L",4,2,0,6,0,174,0,90,1,"b","e","b","e",24,8,68,7,7,9,12,15,18,21,23,25,26,null,0.15,"-",0.7,"D",0.16,"-",0.263,8,"-"]
[338,"D","L","L",4,2,0,6,0,117,0,72,0,"b","e","b","e",27,5,68,10,11,12,15,17,20,21,21,22,22,null,0.14,"-",0.7,"D",0.16,"-",0.263,8,"-"]
[339,"N","L","L",2,3,0,5,0,47,0,30,0,"b","e","b","i",36,6,62,14,14,15,17,19,20,20,19,17,16,null,0.13,"-",0.58,"D",0.16,"-",0.26,8,"-"]
[340,"S","L","H",1,5,0,4,0,0,0,0,0,"b","b","b","b",52,9,41,23,22,22,22,20,18,15,12,8,6,null,0.15,"-",0.49,"D",0.14,"-",0.253,8,"-"]
[341,"V","L","H",4,6,1,2,0,0,0,0,3,"b","b","b","b",70,11,24,31,27,21,19,16,14,10,7,4,3,null,0.25,"-",0.34,"-",0.17,"-",0.253,8,"-"]
[342,"I","L","H",6,7,0,1,0,0,0,0,6,"b","b","b","b",82,8,13,37,31,20,16,12,9,6,3,1,1,null,0.19,"-",0.28,"-",0.16,"-",0.253,8,"-"]
[343,"F","L","H",7,8,0,0,0,0,0,0,1,"b","b","b","b",84,7,10,27,26,22,21,18,14,9,5,2,1,null,0.16,"-",0.24,"-",0.13,"-",0.242,9,"-"]
[344,"L","L","H",7,8,0,1,0,0,0,0,3,"b","b","b","b",83,5,13,30,27,22,19,16,13,9,6,3,2,null,0.16,"-",0.28,"-",0.13,"-",0.25,9,"-"]
[345,"L","L","H",7,8,0,1,0,0,0,0,5,"b","b","b","b",85,5,11,35,30,22,18,14,10,6,3,1,0,null,0.14,"-",0.28,"-",0.14,"-",0.253,8,"-"]
[346,"V","L","H",7,8,0,1,0,0,0,0,9,"b","b","b","b",87,3,10,42,33,16,10,7,5,3,2,1,0,null,0.07,"-",0.23,"-",0.13,"-",0.263,8,"-"]
[347,"Q","L","H",8,9,0,0,0,0,0,0,2,"b","b","b","b",91,2,7,26,24,19,18,17,15,11,8,4,3,null,0.06,"-",0.34,"-",0.13,"-",0.283,7,"-"]
[348,"S","L","H",8,9,0,0,0,26,0,20,2,"b","e","b","i",90,1,9,16,17,18,22,24,23,19,13,7,4,null,0.07,"-",0.41,"-",0.15,"-",0.283,7,"-"]
[349,"M","L","H",8,9,0,0,0,0,0,0,7,"b","b","b","b",91,1,8,38,31,19,13,10,7,4,2,1,0,null,0.08,"-",0.41,"-",0.19,"-",0.283,7,"-"]
[350,"V","L","H",8,9,0,0,0,0,0,0,3,"b","b","b","b",93,0,5,29,26,20,18,16,13,9,6,3,2,null,0.08,"-",0.54,"D",0.19,"-",0.273,8,"-"]
[351,"V","L","H",8,9,0,0,0,59,0,42,3,"b","e","b","e",91,1,7,7,8,9,12,16,21,25,25,19,14,null,0.11,"-",0.56,"D",0.17,"-",0.273,8,"-"]
[352,"D","L","H",8,9,0,0,0,48,0,30,3,"b","e","b","i",91,0,7,9,11,15,21,25,27,25,18,10,6,null,0.16,"-",0.6,"D",0.13,"-",0.283,7,"-"]
[353,"L","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",92,0,5,42,33,18,11,7,4,3,2,1,1,null,0.19,"-",0.51,"D",0.13,"-",0.273,8,"-"]
[354,"K","L","H",8,9,0,0,0,61,0,30,2,"b","e","b","i",91,1,7,14,14,16,21,24,25,21,16,9,5,null,0.24,"-",0.48,"D",0.15,"-",0.303,7,"-"]

{"sheet":"E12","index":18,"n_rows":46,"n_cols":40,"rows_kept":46,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
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[422,"A","L","L",4,2,1,6,0,59,0,56,1,"b","e","b","e",21,14,67,10,11,12,15,17,20,22,23,22,20,null,0.29,"-",0.58,"D",0.26,"-",0.28,7,"-"]
[423,"L","L","L",4,1,1,6,0,9,0,6,3,"b","b","b","b",13,20,69,23,25,26,25,20,15,10,7,6,5,null,0.33,"-",0.54,"D",0.26,"-",0.273,8,"-"]
[424,"D","L","L",5,1,1,6,0,91,0,56,2,"b","e","b","e",16,16,70,7,7,9,11,15,19,22,24,24,23,null,0.32,"-",0.51,"D",0.3,"-",0.283,7,"-"]
[425,"W","L","L",5,1,1,6,0,27,0,12,1,"b","b","b","i",19,14,72,17,18,20,22,21,19,16,13,12,12,null,0.36,"-",0.45,"-",0.27,"-",0.263,8,"-"]
[426,"W","L","L",5,1,1,6,0,27,0,12,1,"b","b","b","i",18,16,71,18,19,20,22,21,19,15,12,10,8,null,0.3,"-",0.51,"D",0.2,"-",0.26,8,"-"]
[427,"P","L","L",4,2,1,6,0,40,0,30,1,"b","e","b","i",22,16,66,15,15,16,18,20,21,20,18,15,12,null,0.23,"-",0.56,"D",0.17,"-",0.27,8,"-"]
[428,"K","L","L",3,2,1,5,0,86,0,42,1,"b","e","b","e",29,14,62,10,10,11,14,17,20,22,21,19,17,null,0.24,"-",0.56,"D",0.17,"-",0.283,7,"-"]
[429,"I","L","H",1,5,0,3,0,0,0,0,0,"b","b","b","b",52,10,41,25,24,23,22,19,15,11,8,6,5,null,0.18,"-",0.49,"D",0.15,"-",0.293,7,"-"]
[430,"D","L","H",2,5,0,3,0,48,0,30,1,"b","e","b","i",59,7,39,13,13,14,17,19,21,21,19,16,13,null,0.18,"-",0.56,"D",0.18,"-",0.303,7,"-"]
[431,"A","L","H",4,7,0,2,0,31,0,30,1,"b","e","b","i",72,6,24,14,14,15,17,19,20,20,17,14,11,null,0.18,"-",0.52,"D",0.2,"-",0.313,6,"-"]
[432,"V","L","H",5,7,0,1,0,0,0,0,3,"b","b","b","b",76,7,20,32,28,22,19,16,12,9,6,4,3,null,0.17,"-",0.41,"-",0.21,"-",0.313,6,"-"]
[433,"Y","L","H",5,7,0,2,0,0,0,0,0,"b","b","b","b",74,6,24,24,23,23,22,20,17,13,9,6,5,null,0.16,"-",0.41,"-",0.14,"-",0.323,6,"-"]
[434,"C","L","H",5,7,0,2,0,40,0,30,0,"b","e","b","i",74,6,24,18,17,17,18,20,21,19,16,12,9,null,0.14,"-",0.51,"D",0.17,"-",0.323,6,"-"]
[435,"H","L","H",4,6,0,2,0,0,0,0,0,"b","b","b","b",69,6,28,23,23,22,21,20,17,14,10,7,5,null,0.11,"-",0.46,"-",0.16,"-",0.303,7,"-"]
[436,"S","L","H",3,6,0,3,0,0,0,0,5,"b","b","b","b",65,5,34,33,28,19,15,13,10,8,6,5,4,null,0.09,"-",0.43,"-",0.14,"-",0.283,7,"-"]
[437,"V","L","H",4,7,0,2,0,0,0,0,0,"b","b","b","b",72,4,24,23,22,21,20,18,15,13,10,8,7,null,0.08,"-",0.49,"D",0.13,"-",0.283,7,"-"]
[438,"E","L","H",4,7,0,2,0,58,0,30,1,"b","e","b","i",74,4,25,16,16,17,20,22,23,21,17,12,9,null,0.1,"-",0.52,"D",0.15,"-",0.293,7,"-"]
[439,"L","L","H",6,8,0,1,0,0,0,0,4,"b","b","b","b",81,3,16,33,29,21,17,14,11,8,6,4,3,null,0.12,"-",0.41,"-",0.21,"-",0.293,7,"-"]
[440,"R","L","H",7,8,0,1,0,0,0,0,0,"b","b","b","b",88,2,11,22,21,21,21,21,18,14,10,6,4,null,0.11,"-",0.41,"-",0.23,"-",0.293,7,"-"]
[441,"N","L","H",7,8,0,1,0,47,0,30,2,"b","e","b","i",88,2,10,13,13,14,17,20,22,22,19,13,10,null,0.13,"-",0.47,"D",0.17,"-",0.3,7,"-"]
[442,"M","L","H",7,8,0,1,0,0,0,0,2,"b","b","b","b",88,2,10,28,27,24,21,18,14,9,5,3,1,null,0.13,"-",0.38,"-",0.19,"-",0.283,7,"-"]
[443,"F","L","H",8,9,0,0,0,0,0,0,7,"b","b","b","b",90,2,8,40,32,20,14,10,7,4,2,1,0,null,0.11,"-",0.32,"-",0.22,"-",0.283,7,"-"]
[444,"G","L","H",8,9,0,0,0,0,0,0,0,"b","b","b","b",92,1,6,22,21,19,20,19,18,15,11,7,5,null,0.09,"-",0.4,"-",0.29,"-",0.303,7,"-"]
[445,"E","L","H",8,9,0,0,0,58,0,30,3,"b","e","b","i",92,1,7,9,10,13,18,21,24,23,19,13,8,null,0.09,"-",0.43,"-",0.21,"-",0.3,7,"-"]
[446,"T","L","H",7,8,0,1,0,0,0,0,3,"b","b","b","b",89,1,11,29,26,21,19,17,13,10,6,4,2,null,0.11,"-",0.34,"-",0.22,"-",0.293,7,"-"]
[447,"L","L","H",7,8,0,1,0,0,0,0,6,"b","b","b","b",88,2,10,36,30,21,16,13,9,6,4,2,1,null,0.11,"-",0.36,"-",0.27,"-",0.293,7,"-"]
[448,"H","L","H",7,8,0,1,0,55,0,30,2,"b","e","b","i",88,2,11,13,13,15,18,21,23,23,20,14,10,null,0.12,"-",0.44,"-",0.29,"-",0.333,6,"-"]
[449,"K","L","H",6,8,0,1,0,86,0,42,3,"b","e","b","e",83,2,16,6,8,11,16,20,24,26,23,17,12,null,0.18,"-",0.47,"D",0.29,"-",0.33,6,"-"]
[450,"A","L","H",5,7,0,2,0,0,0,0,2,"b","b","b","b",77,5,22,27,24,21,19,17,14,11,9,6,5,null,0.2,"-",0.46,"-",0.24,"-",0.323,6,"-"]
[451,"V","L","H",4,6,0,2,0,0,0,0,1,"b","b","b","b",72,8,25,26,24,21,20,18,14,11,9,7,6,null,0.21,"-",0.49,"D",0.22,"-",0.333,6,"-"]
[452,"Q","L","H",2,5,0,3,0,110,0,56,2,"b","e","b","e",61,9,35,10,10,11,13,16,19,23,24,22,20,null,0.22,"-",0.55,"D",0.33,"-",0.384,4,"-"]
[453,"G","L","H",1,5,0,3,0,35,0,42,2,"b","e","b","e",56,9,40,10,11,13,17,20,23,24,22,18,15,null,0.22,"-",0.55,"D",0.34,"-",0.364,5,"-"]
[454,"C","L","H",0,4,1,4,0,16,0,12,0,"b","b","b","i",50,12,44,21,21,21,22,20,17,13,10,9,8,null,0.28,"-",0.54,"D",0.2,"-",0.343,5,"-"]
[455,"G","L","L",0,4,1,4,0,25,0,30,1,"b","e","b","i",46,16,47,14,14,15,18,20,22,22,21,18,16,null,0.34,"-",0.57,"D",0.22,"-",0.364,5,"-"]
[456,"A","L","L",2,3,1,5,0,95,0,90,1,"b","e","b","e",34,15,58,9,10,11,13,15,17,19,21,23,24,null,0.34,"-",0.55,"D",0.22,"-",0.394,4,"-"]
[457,"H","L","L",3,2,1,6,0,55,0,30,0,"b","e","b","i",26,15,65,12,13,15,18,20,21,21,20,18,16,null,0.31,"-",0.53,"D",0.19,"-",0.364,5,"-"]
[458,"P","L","L",5,1,1,6,0,16,0,12,1,"b","b","b","i",20,14,72,18,20,21,23,22,19,16,14,14,13,null,0.35,"-",0.53,"D",0.22,"-",0.364,5,"-"]
[459,"A","L","L",4,1,1,6,0,31,0,30,0,"b","e","b","i",21,16,70,13,13,14,17,19,21,21,21,20,18,null,0.39,"-",0.56,"D",0.31,"-",0.384,4,"-"]
[460,"I","L","L",4,1,2,6,0,20,0,12,0,"b","b","b","i",19,23,63,20,21,22,23,21,18,14,11,9,8,null,0.44,"-",0.56,"D",0.24,"-",0.384,4,"-"]
[461,"R","L","L",3,1,2,5,0,49,0,20,1,"b","e","b","i",19,25,62,15,16,18,20,22,22,19,16,13,11,null,0.42,"-",0.55,"D",0.25,"-",0.394,4,"-"]
[462,"M","L","L",3,1,2,5,0,22,0,12,0,"b","b","b","i",19,24,63,20,20,21,22,21,19,16,13,11,9,null,0.51,"-",0.59,"D",0.19,"-",0.434,2,"-"]
[463,"A","L","L",4,2,2,5,0,12,0,12,0,"b","b","b","i",22,22,63,18,18,19,20,20,20,18,17,15,13,null,0.52,"D",0.61,"D",0.24,"-",0.469,1,"-"]
[464,"P","L","L",2,2,1,5,0,16,0,12,0,"b","b","b","i",30,20,59,19,19,20,21,20,19,18,16,14,12,null,0.55,"D",0.57,"D",0.29,"-",0.525,0,"D"]

{"sheet":"E17","index":19,"n_rows":54,"n_cols":40,"rows_kept":54,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
[616,"Q","L","L",1,3,1,5,0,83,0,42,0,"b","e","b","e",36,17,54,10,10,12,15,18,20,22,22,21,19,null,0.2,"-",0.56,"D",0.71,"D",0.424,3,"-"]
[617,"A","L","L",1,3,1,4,0,12,0,12,0,"b","b","b","i",38,17,54,19,20,21,22,19,17,14,13,12,12,null,0.17,"-",0.55,"D",0.82,"D",0.384,4,"-"]
[618,"D","L","L",1,3,1,5,0,68,0,42,1,"b","e","b","e",36,16,54,12,12,13,16,18,20,21,20,18,16,null,0.16,"-",0.52,"D",0.51,"-",0.32,6,"-"]
[619,"R","L","L",1,3,1,4,0,49,0,20,1,"b","e","b","i",35,17,50,17,18,19,21,22,21,18,14,11,9,null,0.13,"-",0.51,"D",0.35,"-",0.29,7,"-"]
[620,"S","L","L",1,3,1,4,0,0,0,0,1,"b","b","b","b",35,20,48,24,23,21,20,18,16,13,11,9,8,null,0.11,"-",0.48,"D",0.2,"-",0.273,8,"-"]
[621,"S","L","L",0,3,2,3,0,0,0,0,2,"b","b","b","b",40,25,41,26,24,21,19,17,15,13,11,9,7,null,0.13,"-",0.45,"-",0.15,"-",0.263,8,"-"]
[622,"C","L","H",1,4,2,2,0,0,0,0,3,"b","b","b","b",47,30,28,29,27,22,19,16,13,9,7,5,4,null,0.12,"-",0.38,"-",0.13,"-",0.263,8,"-"]
[623,"H","L","H",2,4,2,2,0,0,0,0,2,"b","b","b","b",53,31,23,28,26,21,19,17,14,10,7,5,4,null,0.1,"-",0.35,"-",0.13,"-",0.263,8,"-"]
[624,"F","L","H",2,5,3,1,0,0,0,0,3,"b","b","b","b",56,32,18,29,26,21,18,15,12,9,6,4,3,null,0.11,"-",0.36,"-",0.13,"-",0.263,8,"-"]
[625,"L","L","H",3,5,2,1,0,0,0,0,3,"b","b","b","b",60,29,17,29,27,22,19,16,13,9,6,4,3,null,0.11,"-",0.33,"-",0.13,"-",0.263,8,"-"]
[626,"L","L","H",3,6,2,1,0,0,0,0,4,"b","b","b","b",65,26,16,33,29,21,17,14,10,7,4,2,2,null,0.12,"-",0.29,"-",0.15,"-",0.273,8,"-"]
[627,"F","L","H",4,6,2,1,0,0,0,0,4,"b","b","b","b",67,23,16,32,28,21,18,14,11,7,5,3,2,null,0.09,"-",0.29,"-",0.13,"-",0.273,8,"-"]
[628,"Y","L","H",4,6,2,1,0,0,0,0,3,"b","b","b","b",65,24,17,28,25,21,18,15,12,10,7,5,4,null,0.07,"-",0.34,"-",0.14,"-",0.29,7,"-"]
[629,"G","L","H",4,6,2,1,0,0,0,0,2,"b","b","b","b",65,25,17,28,25,21,19,17,14,10,7,5,4,null,0.08,"-",0.32,"-",0.13,"-",0.283,7,"-"]
[630,"V","L","H",3,5,2,1,0,0,0,0,4,"b","b","b","b",64,27,18,33,29,21,17,14,10,7,5,3,2,null,0.08,"-",0.29,"-",0.14,"-",0.283,7,"-"]
[631,"G","L","H",3,5,2,1,0,0,0,0,4,"b","b","b","b",63,26,19,31,27,20,17,14,11,9,7,5,4,null,0.09,"-",0.32,"-",0.16,"-",0.293,7,"-"]
[632,"C","L","H",2,5,2,1,0,0,0,0,2,"b","b","b","b",58,30,20,26,24,21,19,16,13,11,8,6,5,null,0.11,"-",0.37,"-",0.2,"-",0.293,7,"-"]
[633,"D","L","H",2,5,2,2,0,32,0,20,1,"b","e","b","i",56,29,24,18,18,19,21,22,22,19,15,10,8,null,0.12,"-",0.36,"-",0.27,"-",0.313,6,"-"]
[634,"I","L","H",2,4,2,2,0,0,0,0,4,"b","b","b","b",53,28,27,31,27,21,17,14,11,8,6,5,4,null,0.13,"-",0.38,"-",0.29,"-",0.313,6,"-"]
[635,"P","L","H",2,5,2,2,0,0,0,0,2,"b","b","b","b",55,25,27,26,24,20,19,17,14,12,10,8,7,null,0.13,"-",0.41,"-",0.38,"-",0.343,5,"-"]
[636,"S","L","H",1,4,2,3,0,39,0,30,1,"b","e","b","i",52,23,33,17,16,16,18,20,21,20,18,15,13,null,0.15,"-",0.47,"D",0.45,"-",0.374,4,"-"]
[637,"S","L","H",1,4,1,3,0,0,0,0,0,"b","b","b","b",50,19,37,20,19,19,19,19,19,17,15,12,11,null,0.18,"-",0.46,"-",0.47,"-",0.374,4,"-"]
[638,"G","L","H",1,4,1,3,0,0,0,0,0,"b","b","b","b",49,17,39,23,22,20,20,19,16,14,11,10,9,null,0.16,"-",0.49,"D",0.43,"-",0.364,5,"-"]
[639,"N","L","H",0,4,1,4,0,65,0,42,0,"b","e","b","e",46,16,45,13,13,13,15,18,20,21,21,19,18,null,0.19,"-",0.54,"D",0.44,"-",0.364,5,"-"]
[640,"T","L","H",0,4,1,4,0,42,0,30,1,"b","e","b","i",47,15,46,13,14,16,18,20,21,20,19,16,15,null,0.15,"-",0.55,"D",0.48,"-",0.374,4,"-"]
[641,"S","L","H",0,4,1,4,0,54,0,42,0,"b","e","b","e",48,13,45,11,11,13,16,18,20,21,21,20,19,null,0.14,"-",0.55,"D",0.42,"-",0.374,4,"-"]
[642,"Q","L","H",0,4,1,4,0,110,0,56,1,"b","e","b","e",48,13,47,9,10,11,14,16,19,21,22,21,20,null,0.17,"-",0.58,"D",0.48,"-",0.374,4,"-"]
[643,"M","L","L",1,3,1,5,0,22,0,12,1,"b","b","b","i",40,12,53,18,19,21,22,20,17,14,12,11,10,null,0.14,"-",0.61,"D",0.6,"D",0.374,4,"-"]
[644,"S","L","L",2,3,0,5,0,39,0,30,1,"b","e","b","i",36,9,58,12,12,14,17,20,22,22,20,17,14,null,0.13,"-",0.64,"D",0.42,"-",0.354,5,"-"]
[645,"M","L","H",0,5,0,4,0,56,0,30,1,"b","e","b","i",51,9,42,9,10,12,16,18,20,20,19,16,14,null,0.15,"-",0.62,"D",0.3,"-",0.343,5,"-"]
[646,"D","L","H",2,6,0,3,0,68,0,42,1,"b","e","b","e",62,5,36,13,13,14,17,19,21,22,20,17,14,null,0.15,"-",0.58,"D",0.3,"-",0.343,5,"-"]
[647,"H","L","H",6,8,0,1,0,0,0,0,1,"b","b","b","b",83,4,14,25,23,20,20,18,15,12,9,6,5,null,0.12,"-",0.54,"D",0.27,"-",0.323,6,"-"]
[648,"E","L","H",8,8,0,0,0,58,0,30,2,"b","e","b","i",89,3,9,11,12,14,18,20,22,21,18,13,9,null,0.11,"-",0.51,"D",0.37,"-",0.35,5,"-"]
[649,"E","L","H",8,8,0,0,0,58,0,30,2,"b","e","b","i",89,4,7,12,13,15,19,22,23,22,17,11,7,null,0.12,"-",0.45,"-",0.33,"-",0.343,5,"-"]
[650,"L","L","H",8,9,0,0,0,0,0,0,3,"b","b","b","b",90,3,7,32,28,22,19,16,12,8,5,3,1,null,0.13,"-",0.37,"-",0.41,"-",0.333,6,"-"]
[651,"L","L","H",8,8,0,0,0,0,0,0,0,"b","b","b","b",89,3,8,25,24,23,22,19,16,12,8,5,3,null,0.1,"-",0.36,"-",0.37,"-",0.333,6,"-"]
[652,"R","L","H",8,9,0,0,0,74,0,30,2,"b","e","b","i",90,2,8,15,15,16,20,22,24,21,15,9,5,null,0.11,"-",0.38,"-",0.29,"-",0.333,6,"-"]
[653,"T","L","H",7,8,0,1,0,0,0,0,0,"b","b","b","b",87,2,11,23,23,22,21,20,17,12,8,5,3,null,0.08,"-",0.34,"-",0.26,"-",0.354,5,"-"]
[654,"P","L","H",8,8,0,0,0,0,0,0,4,"b","b","b","b",89,2,9,33,28,20,17,14,11,7,4,2,1,null,0.08,"-",0.35,"-",0.29,"-",0.374,4,"-"]
[655,"G","L","H",7,8,0,1,0,0,0,0,2,"b","b","b","b",88,2,10,26,24,20,18,16,14,12,9,6,4,null,0.08,"-",0.41,"-",0.38,"-",0.434,2,"-"]
[656,"A","L","H",7,8,0,1,0,21,0,20,2,"b","e","b","i",88,2,10,15,16,18,22,24,24,20,14,8,5,null,0.09,"-",0.39,"-",0.68,"D",0.465,1,"-"]
[657,"S","L","H",7,8,0,1,0,0,0,0,1,"b","b","b","b",86,2,15,25,23,21,19,18,15,12,9,6,4,null,0.09,"-",0.41,"-",0.61,"D",0.459,2,"-"]
[658,"L","L","H",7,8,0,1,0,0,0,0,2,"b","b","b","b",84,3,14,27,25,21,19,16,13,10,7,5,4,null,0.11,"-",0.46,"-",0.64,"D",0.444,2,"-"]
[659,"R","L","H",5,7,0,2,0,74,0,30,2,"b","e","b","i",77,4,21,13,13,13,16,19,22,22,19,13,10,null,0.13,"-",0.5,"D",0.64,"D",0.444,2,"-"]
[660,"K","L","H",5,7,0,1,0,61,0,30,2,"b","e","b","i",76,5,19,12,13,14,17,20,22,21,18,13,10,null,0.13,"-",0.45,"-",0.7,"D",0.455,2,"-"]
[661,"G","L","H",4,6,0,2,0,16,0,20,0,"b","e","b","i",67,10,25,19,18,19,20,21,20,17,14,11,8,null,0.15,"-",0.48,"D",0.6,"D",0.444,2,"-"]
[662,"K","L","H",3,6,1,2,0,86,0,42,1,"b","e","b","e",65,12,28,13,13,15,17,19,20,21,19,17,15,null,0.17,"-",0.52,"D",0.65,"D",0.465,1,"-"]
[663,"G","L","H",2,5,1,3,0,25,0,30,1,"b","e","b","i",58,12,34,14,14,15,17,19,21,21,19,16,14,null,0.18,"-",0.52,"D",0.82,"D",0.465,1,"-"]
[664,"N","L","H",1,5,1,3,0,3,0,2,0,"b","b","b","b",53,13,39,19,20,20,20,19,17,15,13,12,11,null,0.18,"-",0.54,"D",0.78,"D",0.414,3,"-"]
[665,"S","L","H",0,4,1,4,0,54,0,42,1,"b","e","b","e",50,15,44,12,13,14,17,20,21,22,21,19,17,null,0.21,"-",0.6,"D",0.61,"D",0.404,3,"-"]
[666,"S","L","L",0,3,1,4,0,72,0,56,2,"b","e","b","e",43,14,52,8,8,10,13,16,20,23,24,22,21,null,0.23,"-",0.62,"D",0.61,"D",0.394,4,"-"]
[667,"M","L","L",1,3,1,4,0,22,0,12,1,"b","b","b","i",40,17,52,17,19,20,22,20,18,15,13,12,11,null,0.27,"-",0.59,"D",0.33,"-",0.364,5,"-"]

{"sheet":"E18E19","index":20,"n_rows":110,"n_cols":40,"rows_kept":110,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
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[757,"K","L","H",8,8,0,0,0,41,0,20,1,"b","e","b","i",89,3,8,16,16,17,19,22,22,20,16,10,7,null,0.08,"-",0.4,"-",0.19,"-",0.283,7,"-"]
[758,"R","L","H",8,9,0,0,0,49,0,20,2,"b","e","b","i",90,2,8,16,17,20,24,26,24,18,11,5,3,null,0.16,"-",0.41,"-",0.21,"-",0.29,7,"-"]
[759,"V","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",93,2,5,43,33,16,10,7,4,2,1,0,0,null,0.21,"-",0.32,"-",0.23,"-",0.283,7,"-"]
[760,"M","L","H",8,9,0,0,0,0,0,0,0,"b","b","b","b",93,2,5,24,23,22,22,20,16,11,7,3,2,null,0.22,"-",0.35,"-",0.24,"-",0.283,7,"-"]
[761,"A","L","H",8,9,0,0,0,31,0,30,3,"b","e","b","i",93,2,6,13,13,15,19,23,26,25,21,13,8,null,0.27,"-",0.35,"-",0.25,"-",0.273,8,"-"]
[762,"L","L","H",8,9,0,0,0,0,0,0,1,"b","b","b","b",93,1,5,27,26,24,23,20,15,9,5,2,1,null,0.24,"-",0.28,"-",0.18,"-",0.273,8,"-"]
[763,"L","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",94,2,5,43,34,19,12,8,5,3,2,1,1,null,0.18,"-",0.32,"-",0.19,"-",0.263,8,"-"]
[764,"R","L","H",7,8,0,1,0,29,0,12,0,"b","b","b","i",88,3,11,17,17,19,20,20,20,18,15,11,8,null,0.18,"-",0.37,"-",0.22,"-",0.3,7,"-"]
[765,"R","L","H",6,8,0,1,0,74,0,30,2,"b","e","b","i",81,4,16,10,11,14,18,22,23,21,17,12,8,null,0.19,"-",0.45,"-",0.28,"-",0.313,6,"-"]
[766,"I","L","H",2,5,0,3,0,0,0,0,0,"b","b","b","b",58,5,37,25,25,24,22,18,13,8,5,3,2,null,0.18,"-",0.48,"D",0.28,"-",0.3,7,"-"]
[767,"E","L","L",3,3,0,6,0,81,0,42,1,"b","e","b","e",32,5,66,12,12,13,15,18,21,23,23,21,18,null,0.14,"-",0.68,"D",0.41,"-",0.323,6,"-"]
[768,"H","L","L",7,1,0,8,0,22,0,12,1,"b","b","b","i",10,5,84,14,16,19,22,22,20,17,14,12,10,null,0.15,"-",0.62,"D",0.56,"-",0.333,6,"-"]
[769,"P","L","L",7,0,0,8,0,0,0,0,0,"b","b","b","b",9,6,84,19,19,18,19,18,18,17,16,14,13,null,0.15,"-",0.58,"D",0.62,"D",0.354,5,"-"]
[770,"T","L","L",6,1,0,7,0,0,0,0,0,"b","b","b","b",13,8,80,21,21,21,21,20,17,15,12,11,9,null,0.16,"-",0.47,"D",0.58,"D",0.323,6,"-"]
[771,"A","L","L",4,2,1,6,0,21,0,20,0,"b","e","b","i",24,11,64,17,17,17,19,20,20,18,16,13,12,null,0.18,"-",0.52,"D",0.57,"-",0.313,6,"-"]
[772,"G","L","L",2,3,1,5,0,0,0,0,1,"b","b","b","b",34,12,56,26,24,21,20,18,16,12,9,6,4,null,0.21,"-",0.37,"-",0.57,"-",0.303,7,"-"]
[773,"N","L","H",1,5,1,3,0,0,0,0,3,"b","b","b","b",52,10,38,29,26,21,19,16,13,9,5,3,2,null,0.25,"-",0.34,"-",0.69,"D",0.303,7,"-"]
[774,"T","L","H",5,7,0,2,0,0,0,0,2,"b","b","b","b",73,6,21,29,27,22,20,17,13,9,6,3,2,null,0.22,"-",0.34,"-",0.65,"D",0.3,7,"-"]
[775,"E","L","H",7,8,0,1,0,0,0,0,0,"b","b","b","b",84,5,12,23,22,20,20,19,17,13,9,5,3,null,0.19,"-",0.41,"-",0.61,"D",0.313,6,"-"]

{"sheet":"E20","index":21,"n_rows":30,"n_cols":40,"rows_kept":30,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
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["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
[776,"A","L","H",7,8,0,1,0,0,0,0,7,"b","b","b","b",88,2,10,39,31,17,13,10,8,5,3,1,1,null,0.14,"-",0.26,"-",0.61,"D",0.32,6,"-"]
[777,"W","L","H",9,9,0,0,0,0,0,0,7,"b","b","b","b",94,1,4,40,33,21,16,11,7,4,2,0,0,null,0.09,"-",0.27,"-",0.77,"D",0.303,7,"-"]
[778,"E","L","H",9,9,0,0,0,38,0,20,1,"b","e","b","i",94,0,4,18,18,18,21,22,22,17,12,6,3,null,0.06,"-",0.33,"-",0.6,"D",0.323,6,"-"]
[779,"D","L","H",8,9,0,0,0,48,0,30,2,"b","e","b","i",93,1,5,10,12,16,21,24,25,21,14,7,3,null,0.07,"-",0.42,"-",0.69,"D",0.364,5,"-"]
[780,"T","L","H",8,9,0,0,0,0,0,0,8,"b","b","b","b",93,0,5,41,32,18,12,9,6,4,2,1,0,null,0.06,"-",0.34,"-",0.64,"D",0.333,6,"-"]
[781,"H","L","H",8,9,0,0,0,0,0,0,4,"b","b","b","b",94,0,5,33,29,23,19,15,10,6,3,1,1,null,0.05,"-",0.33,"-",0.63,"D",0.343,5,"-"]
[782,"A","L","H",8,9,0,0,0,44,0,42,2,"b","e","b","e",93,0,6,8,9,11,14,18,21,23,20,14,9,null,0.04,"-",0.45,"-",0.77,"D",0.343,5,"-"]
[783,"K","L","H",8,9,0,0,0,61,0,30,3,"b","e","b","i",91,1,9,9,11,16,22,26,27,22,14,7,3,null,0.05,"-",0.43,"-",0.82,"D",0.343,5,"-"]
[784,"W","L","H",8,9,0,0,0,0,0,0,7,"b","b","b","b",92,1,6,39,33,22,15,11,7,4,2,1,0,null,0.07,"-",0.29,"-",0.6,"D",0.283,7,"-"]
[785,"E","L","H",8,9,0,0,0,58,0,30,3,"b","e","b","i",93,0,6,12,13,17,23,26,27,22,15,8,4,null,0.05,"-",0.41,"-",0.46,"-",0.293,7,"-"]
[786,"Q","L","H",8,8,0,0,0,59,0,30,2,"b","e","b","i",89,1,9,12,13,15,18,22,24,24,19,13,9,null,0.06,"-",0.45,"-",0.36,"-",0.293,7,"-"]
[787,"A","L","H",7,8,0,1,0,0,0,0,6,"b","b","b","b",89,1,10,38,31,20,15,11,8,5,3,2,1,null,0.07,"-",0.38,"-",0.39,"-",0.293,7,"-"]
[788,"T","L","H",7,8,0,1,0,0,0,0,3,"b","b","b","b",88,2,11,29,26,21,19,16,12,9,6,4,3,null,0.08,"-",0.35,"-",0.22,"-",0.293,7,"-"]
[789,"K","L","H",8,9,0,0,0,86,0,42,2,"b","e","b","e",91,2,8,8,9,10,13,17,22,26,26,21,17,null,0.11,"-",0.47,"D",0.31,"-",0.333,6,"-"]
[790,"L","L","H",6,7,0,1,0,19,0,12,1,"b","b","b","i",82,4,17,17,18,21,23,23,21,17,13,9,7,null,0.17,"-",0.48,"D",0.36,"-",0.333,6,"-"]
[791,"I","L","H",6,7,0,1,0,0,0,0,5,"b","b","b","b",79,9,19,34,29,21,17,14,10,7,5,3,3,null,0.26,"-",0.46,"-",0.31,"-",0.333,6,"-"]
[792,"L","L","H",2,5,1,3,0,0,0,0,0,"b","b","b","b",60,13,33,21,21,21,20,19,17,15,13,11,9,null,0.24,"-",0.51,"D",0.44,"-",0.343,5,"-"]
[793,"N","L","H",0,4,1,4,0,65,0,42,2,"b","e","b","e",48,11,47,10,11,13,16,20,23,24,23,19,16,null,0.25,"-",0.6,"D",0.34,"-",0.364,5,"-"]
[794,"Y","L","L",4,2,0,6,0,44,0,20,1,"b","e","b","i",27,9,68,16,17,19,21,22,20,17,14,12,10,null,0.32,"-",0.6,"D",0.3,"-",0.404,3,"-"]
[795,"P","L","L",4,2,1,6,0,27,0,20,1,"b","e","b","i",28,11,68,17,17,19,20,21,20,18,17,16,15,null,0.37,"-",0.65,"D",0.49,"-",0.455,2,"-"]
[796,"K","L","L",2,3,1,5,0,184,0,90,2,"b","e","b","e",33,12,61,5,6,8,10,13,17,21,24,27,28,null,0.4,"-",0.72,"D",0.6,"D",0.545,1,"D"]
[797,"A","L","L",3,2,1,6,0,95,0,90,1,"b","e","b","e",29,12,64,7,8,10,14,17,19,20,21,24,25,null,0.38,"-",0.76,"D",0.8,"D",0.596,3,"D"]
[798,"K","L","L",3,2,1,5,0,147,0,72,1,"b","e","b","e",30,13,64,6,7,9,12,15,18,21,23,24,24,null,0.36,"-",0.72,"D",0.76,"D",0.582,2,"D"]
[799,"M","L","L",3,2,1,5,0,37,0,20,0,"b","e","b","i",31,16,62,13,14,16,19,20,20,19,18,18,18,null,0.4,"-",0.73,"D",0.86,"D",0.556,1,"D"]
[800,"E","L","L",3,2,1,6,0,174,0,90,3,"b","e","b","e",28,14,65,3,4,6,10,13,16,19,23,29,31,null,0.49,"-",0.76,"D",0.89,"D",0.566,1,"D"]
[801,"D","L","L",3,2,0,6,0,146,0,90,3,"b","e","b","e",30,8,68,6,6,8,11,14,16,19,21,27,29,null,0.45,"-",0.72,"D",0.82,"D",0.535,0,"D"]
[802,"G","L","L",3,2,0,6,0,75,0,90,2,"b","e","b","e",29,9,68,9,10,11,14,16,18,18,19,23,25,null,0.42,"-",0.7,"D",0.7,"D",0.535,0,"D"]
[803,"Q","L","L",4,2,1,6,0,178,0,90,2,"b","e","b","e",24,13,65,6,6,8,11,14,17,20,22,26,27,null,0.45,"-",0.71,"D",0.52,"-",0.525,0,"D"]

{"sheet":"E21","index":22,"n_rows":149,"n_cols":40,"rows_kept":149,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
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["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
[804,"A","L","L",4,2,1,6,0,31,0,30,0,"b","e","b","i",25,13,65,12,13,14,17,19,21,21,20,20,18,null,0.47,"-",0.69,"D",0.79,"D",0.525,0,"D"]
[805,"A","L","L",2,3,1,5,0,12,0,12,0,"b","b","b","i",33,13,60,17,18,19,21,21,20,18,16,15,13,null,0.39,"-",0.65,"D",0.71,"D",0.525,0,"D"]
[806,"E","L","L",1,3,1,5,0,81,0,42,0,"b","e","b","e",41,13,54,9,10,12,15,17,20,21,21,21,20,null,0.42,"-",0.63,"D",0.5,"-",0.515,0,"-"]
[807,"S","L","L",1,3,1,4,0,54,0,42,0,"b","e","b","e",42,13,52,11,11,13,15,18,19,21,21,20,19,null,0.51,"-",0.64,"D",0.44,"-",0.535,0,"D"]
[808,"L","L","L",0,4,1,4,0,9,0,6,0,"b","b","b","b",46,18,46,20,20,21,21,21,18,15,12,11,10,null,0.51,"-",0.56,"D",0.53,"-",0.525,0,"D"]
[809,"H","L","L",1,3,1,4,0,22,0,12,1,"b","b","b","i",38,20,52,17,18,19,21,21,19,17,14,12,11,null,0.47,"-",0.56,"D",0.59,"D",0.52,0,"D"]
[810,"K","L","L",2,3,1,5,0,147,0,72,2,"b","e","b","e",35,18,59,7,7,9,12,15,18,21,24,25,25,null,0.42,"-",0.62,"D",0.64,"D",0.535,0,"D"]
[811,"T","L","L",2,2,1,5,0,59,0,42,0,"b","e","b","e",33,18,61,11,12,14,17,20,21,22,21,20,19,null,0.48,"-",0.61,"D",0.43,"-",0.556,1,"D"]
[812,"I","L","L",2,2,2,5,0,20,0,12,0,"b","b","b","i",30,22,58,18,19,20,21,19,17,14,12,12,11,null,0.54,"D",0.57,"D",0.43,"-",0.535,0,"D"]
[813,"V","L","L",3,2,2,5,0,28,0,20,0,"b","e","b","i",27,22,61,14,15,16,19,21,21,21,19,18,16,null,0.46,"-",0.59,"D",0.55,"-",0.531,0,"D"]
[814,"K","L","L",4,2,1,6,0,147,0,72,0,"b","e","b","e",25,17,66,11,11,13,15,17,19,20,21,22,22,null,0.45,"-",0.65,"D",0.48,"-",0.551,1,"D"]
[815,"R","L","L",4,1,1,6,0,74,0,30,0,"b","e","b","i",20,17,68,10,11,14,18,20,21,21,19,19,18,null,0.43,"-",0.64,"D",0.37,"-",0.556,1,"D"]
[816,"R","L","L",4,1,1,6,0,104,0,42,1,"b","e","b","e",21,21,65,10,11,14,17,19,21,22,21,19,17,null,0.54,"D",0.61,"D",0.35,"-",0.515,0,"-"]
[817,"M","L","L",4,2,1,6,0,22,0,12,1,"b","b","b","i",23,20,65,17,18,20,22,21,19,17,14,13,12,null,0.56,"D",0.58,"D",0.43,"-",0.5,0,"-"]
[818,"S","L","L",4,2,1,6,0,93,0,72,1,"b","e","b","e",21,16,68,9,10,11,14,16,19,21,22,24,24,null,0.57,"D",0.57,"D",0.5,"-",0.505,0,"-"]
[819,"H","L","L",4,1,1,6,0,165,0,90,1,"b","e","b","e",20,15,69,9,10,11,15,16,18,19,20,23,24,null,0.55,"D",0.57,"D",0.39,"-",0.49,1,"-"]
[820,"V","L","L",4,1,1,6,0,28,0,20,0,"b","e","b","i",19,18,67,11,13,15,19,21,21,20,18,18,17,null,0.61,"D",0.56,"D",0.28,"-",0.465,1,"-"]
[821,"S","L","L",5,1,1,6,0,117,0,90,1,"b","e","b","e",16,16,71,11,12,12,15,16,18,19,20,23,24,null,0.61,"D",0.54,"D",0.31,"-",0.475,1,"-"]
[822,"G","L","L",5,1,1,6,0,25,0,30,0,"b","e","b","i",19,14,72,13,14,16,19,20,21,20,19,18,17,null,0.6,"D",0.54,"D",0.3,"-",0.455,2,"-"]
[823,"G","L","L",4,2,1,6,0,60,0,72,0,"b","e","b","e",21,13,70,12,13,14,16,18,19,20,20,22,22,null,0.58,"D",0.62,"D",0.3,"-",0.469,1,"-"]
[824,"G","L","L",4,2,1,6,0,16,0,20,0,"b","e","b","i",22,13,69,13,14,17,20,21,21,20,18,17,15,null,0.47,"-",0.59,"D",0.38,"-",0.459,2,"-"]
[825,"S","L","L",4,2,1,6,0,54,0,42,0,"b","e","b","e",24,13,67,12,12,14,16,18,20,21,21,20,19,null,0.47,"-",0.62,"D",0.47,"-",0.444,2,"-"]
[826,"I","L","L",3,2,1,6,0,20,0,12,1,"b","b","b","i",26,14,62,14,15,18,21,21,20,17,15,13,12,null,0.46,"-",0.65,"D",0.51,"-",0.465,1,"-"]
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[916,"N","L","H",3,6,1,2,0,0,0,0,0,"b","b","b","b",64,14,27,23,22,21,21,21,18,15,11,8,5,null,0.27,"-",0.43,"-",0.35,"-",0.283,7,"-"]
[917,"V","L","H",5,7,0,2,0,0,0,0,8,"b","b","b","b",75,9,22,39,31,18,12,10,7,5,4,3,2,null,0.23,"-",0.42,"-",0.23,"-",0.293,7,"-"]
[918,"K","L","H",6,7,0,1,0,86,0,42,2,"b","e","b","e",80,5,17,11,11,14,17,21,24,25,21,15,11,null,0.22,"-",0.48,"D",0.37,"-",0.35,5,"-"]
[919,"D","L","H",6,8,0,1,0,48,0,30,1,"b","e","b","i",81,4,16,15,15,17,19,21,23,23,21,17,14,null,0.27,"-",0.47,"D",0.25,"-",0.32,6,"-"]
[920,"L","L","H",5,7,0,2,0,0,0,0,2,"b","b","b","b",75,7,22,28,26,22,21,19,16,12,9,7,5,null,0.24,"-",0.53,"D",0.27,"-",0.293,7,"-"]
[921,"V","L","H",3,6,0,2,0,0,0,0,5,"b","b","b","b",68,9,29,35,30,21,17,14,11,8,6,4,3,null,0.18,"-",0.37,"-",0.28,"-",0.28,7,"-"]
[922,"G","L","H",0,4,0,4,0,0,0,0,1,"b","b","b","b",52,6,49,24,22,19,18,16,16,15,14,12,10,null,0.13,"-",0.46,"-",0.33,"-",0.273,8,"-"]
[923,"L","L","L",0,4,0,5,0,32,0,20,0,"b","e","b","i",48,5,53,18,18,18,20,21,21,19,16,14,12,null,0.16,"-",0.57,"D",0.19,"-",0.263,8,"-"]
[924,"E","L","L",0,4,1,4,0,23,0,12,0,"b","b","b","i",44,11,53,17,17,18,19,19,18,16,14,11,10,null,0.19,"-",0.41,"-",0.14,"-",0.263,8,"-"]
[925,"L","L","L",1,3,0,5,0,0,0,0,3,"b","b","b","b",39,10,58,30,28,23,20,16,13,10,7,5,4,null,0.2,"-",0.52,"D",0.18,"-",0.263,8,"-"]
[926,"S","L","L",4,2,0,7,0,0,0,0,1,"b","b","b","b",26,5,73,26,25,22,21,19,16,12,8,5,3,null,0.17,"-",0.39,"-",0.17,"-",0.26,8,"-"]
[927,"P","L","H",1,5,0,4,0,0,0,0,2,"b","b","b","b",54,6,43,27,25,21,19,16,14,11,9,7,6,null,0.18,"-",0.49,"D",0.15,"-",0.263,8,"-"]
[928,"A","L","H",4,7,0,2,0,0,0,0,1,"b","b","b","b",71,4,25,25,24,21,20,18,16,12,9,6,5,null,0.22,"-",0.41,"-",0.14,"-",0.253,8,"-"]
[929,"L","L","H",6,7,0,1,0,0,0,0,6,"b","b","b","b",79,5,16,38,32,20,15,11,7,5,2,1,1,null,0.25,"-",0.38,"-",0.14,"-",0.26,8,"-"]
[930,"Y","L","H",7,8,0,1,0,0,0,0,5,"b","b","b","b",85,5,10,36,32,22,18,13,9,5,2,1,0,null,0.16,"-",0.28,"-",0.19,"-",0.253,8,"-"]
[931,"P","L","H",8,8,0,0,0,0,0,0,1,"b","b","b","b",88,3,8,25,24,20,20,18,16,12,8,4,3,null,0.12,"-",0.36,"-",0.15,"-",0.263,8,"-"]
[932,"M","L","H",8,9,0,0,0,0,0,0,1,"b","b","b","b",90,3,7,25,24,21,20,18,16,12,8,4,2,null,0.15,"-",0.38,"-",0.17,"-",0.26,8,"-"]
[933,"L","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",91,2,6,46,35,16,10,6,4,2,1,0,0,null,0.09,"-",0.28,"-",0.18,"-",0.263,8,"-"]
[934,"F","L","H",8,9,0,0,0,0,0,0,6,"b","b","b","b",93,1,6,38,31,20,15,11,7,4,2,1,0,null,0.06,"-",0.39,"-",0.22,"-",0.263,8,"-"]
[935,"N","L","H",8,9,0,0,0,65,0,42,3,"b","e","b","e",91,1,6,7,8,9,13,17,21,23,20,14,9,null,0.05,"-",0.45,"-",0.22,"-",0.273,8,"-"]
[936,"K","L","H",8,9,0,0,0,41,0,20,3,"b","e","b","i",91,0,7,14,15,19,23,25,24,19,12,6,3,null,0.06,"-",0.46,"-",0.22,"-",0.283,7,"-"]
[937,"L","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",92,0,7,45,35,19,11,7,4,2,1,0,0,null,0.08,"-",0.41,"-",0.37,"-",0.283,7,"-"]
[938,"K","L","H",8,9,0,0,0,41,0,20,2,"b","e","b","i",92,0,6,14,15,16,20,23,23,20,15,9,6,null,0.08,"-",0.53,"D",0.36,"-",0.293,7,"-"]
[939,"N","L","H",8,9,0,0,0,87,0,56,4,"b","e","b","e",91,1,6,4,5,6,9,13,19,26,27,22,17,null,0.13,"-",0.56,"D",0.35,"-",0.293,7,"-"]
[940,"T","L","H",8,9,0,0,0,28,0,20,3,"b","e","b","i",90,1,8,14,15,19,23,25,23,18,11,5,2,null,0.18,"-",0.48,"D",0.4,"-",0.273,8,"-"]
[941,"I","L","H",8,9,0,0,0,0,0,0,7,"b","b","b","b",91,1,7,39,32,19,13,9,6,4,2,1,1,null,0.21,"-",0.43,"-",0.32,"-",0.283,7,"-"]
[942,"S","L","H",8,8,0,0,0,39,0,30,2,"b","e","b","i",89,2,9,11,12,14,18,21,24,24,22,15,11,null,0.2,"-",0.55,"D",0.49,"-",0.273,8,"-"]
[943,"K","L","H",6,7,0,1,0,114,0,56,4,"b","e","b","e",82,4,17,3,4,6,10,14,20,26,28,24,19,null,0.22,"-",0.54,"D",0.34,"-",0.27,8,"-"]
[944,"F","L","H",4,6,0,2,0,0,0,0,1,"b","b","b","b",73,5,27,26,25,23,21,19,15,11,7,5,3,null,0.25,"-",0.49,"D",0.36,"-",0.263,8,"-"]
[945,"F","L","H",1,5,0,3,0,0,0,0,0,"b","b","b","b",57,9,41,24,24,23,23,20,16,12,9,7,6,null,0.22,"-",0.56,"D",0.27,"-",0.263,8,"-"]
[946,"D","L","L",2,3,0,5,0,91,0,56,3,"b","e","b","e",37,7,59,7,8,9,11,14,18,22,24,23,22,null,0.24,"-",0.68,"D",0.26,"-",0.283,7,"-"]
[947,"S","L","L",4,2,0,6,0,72,0,56,1,"b","e","b","e",28,6,68,6,7,10,14,17,20,22,23,23,23,null,0.24,"-",0.67,"D",0.18,"-",0.303,7,"-"]
[948,"Q","L","L",4,2,0,6,0,142,0,72,2,"b","e","b","e",27,7,69,7,8,9,12,15,18,21,23,25,25,null,0.27,"-",0.69,"D",0.15,"-",0.323,6,"-"]
[949,"G","L","L",5,2,0,7,0,35,0,42,0,"b","e","b","e",21,9,72,11,12,14,16,18,20,21,21,21,20,null,0.27,"-",0.69,"D",0.22,"-",0.354,5,"-"]
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{"sheet":"E25","index":23,"n_rows":41,"n_cols":40,"rows_kept":41,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
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[1068,"L","L","H",3,6,0,3,0,0,0,0,4,"b","b","b","b",65,5,33,33,29,21,17,14,10,7,5,3,2,null,0.09,"-",0.53,"D",0.46,"-",0.354,5,"-"]
[1069,"D","L","H",3,6,0,3,0,48,0,30,1,"b","e","b","i",69,3,31,17,16,15,17,19,21,20,18,14,12,null,0.08,"-",0.51,"D",0.61,"D",0.364,5,"-"]
[1070,"Q","L","H",6,8,0,1,0,39,0,20,2,"b","e","b","i",81,2,16,16,16,18,21,23,23,20,15,9,6,null,0.09,"-",0.54,"D",0.5,"-",0.333,6,"-"]
[1071,"A","L","H",7,8,0,1,0,0,0,0,2,"b","b","b","b",85,3,12,26,23,20,19,17,15,12,10,7,6,null,0.08,"-",0.49,"D",0.4,"-",0.303,7,"-"]
[1072,"S","L","H",7,8,0,0,0,0,0,0,6,"b","b","b","b",88,3,10,37,31,19,14,11,9,6,4,2,1,null,0.09,"-",0.39,"-",0.34,"-",0.29,7,"-"]
[1073,"M","L","H",9,9,0,0,0,0,0,0,6,"b","b","b","b",94,1,4,36,30,20,15,12,9,6,4,2,1,null,0.09,"-",0.33,"-",0.35,"-",0.27,8,"-"]
[1074,"E","L","H",9,9,0,0,0,38,0,20,2,"b","e","b","i",94,1,4,14,15,17,21,24,24,21,15,9,5,null,0.11,"-",0.34,"-",0.22,"-",0.263,8,"-"]
[1075,"A","L","H",8,9,0,0,0,0,0,0,4,"b","b","b","b",93,1,6,32,27,19,16,14,12,9,6,3,2,null,0.16,"-",0.23,"-",0.19,"-",0.27,8,"-"]
[1076,"V","L","H",9,9,0,0,0,0,0,0,9,"b","b","b","b",94,2,3,44,34,15,9,6,4,2,1,0,0,null,0.19,"-",0.27,"-",0.19,"-",0.273,8,"-"]
[1077,"V","L","H",9,9,0,0,0,0,0,0,4,"b","b","b","b",94,2,3,31,27,18,15,12,10,7,5,3,2,null,0.22,"-",0.31,"-",0.15,"-",0.3,7,"-"]
[1078,"S","L","H",8,9,0,0,0,39,0,30,3,"b","e","b","i",92,2,5,11,13,16,21,24,26,23,17,9,5,null,0.19,"-",0.4,"-",0.19,"-",0.303,7,"-"]
[1079,"L","L","H",8,9,0,0,0,0,0,0,5,"b","b","b","b",91,1,7,34,29,20,15,11,8,5,3,1,0,null,0.19,"-",0.28,"-",0.14,"-",0.293,7,"-"]
[1080,"L","L","H",8,9,0,0,0,0,0,0,5,"b","b","b","b",90,3,7,35,30,21,16,12,8,5,3,2,1,null,0.21,"-",0.43,"-",0.15,"-",0.283,7,"-"]
[1081,"A","L","H",5,7,0,2,0,59,0,56,1,"b","e","b","e",75,4,23,10,10,11,14,17,19,21,22,19,17,null,0.26,"-",0.47,"D",0.18,"-",0.29,7,"-"]
[1082,"G","L","H",2,5,0,3,0,35,0,42,2,"b","e","b","e",60,6,38,4,6,8,13,17,20,23,23,20,16,null,0.26,"-",0.6,"D",0.25,"-",0.293,7,"-"]
[1083,"L","L","L",4,2,0,6,0,3,0,2,2,"b","b","b","b",25,8,68,26,27,27,24,19,13,8,4,2,2,null,0.28,"-",0.58,"D",0.28,"-",0.303,7,"-"]
[1084,"P","L","L",7,1,0,8,0,57,0,42,1,"b","e","b","e",10,8,82,13,13,14,16,18,21,23,23,20,18,null,0.32,"-",0.68,"D",0.37,"-",0.333,6,"-"]
[1085,"L","L","L",6,0,1,7,0,3,0,2,1,"b","b","b","b",7,16,79,23,25,25,24,19,14,9,7,7,7,null,0.34,"-",0.66,"D",0.59,"D",0.364,5,"-"]
[1086,"Q","L","L",6,0,1,7,0,23,0,12,0,"b","b","b","i",6,17,79,15,16,18,20,20,20,18,16,13,11,null,0.32,"-",0.66,"D",0.58,"D",0.394,4,"-"]
[1087,"P","L","L",6,1,1,7,0,40,0,30,0,"b","e","b","i",10,13,77,16,16,16,18,20,21,20,19,18,16,null,0.43,"-",0.69,"D",0.49,"-",0.367,5,"-"]
[1088,"E","L","L",6,1,0,7,0,174,0,90,1,"b","e","b","e",12,9,78,6,7,9,12,15,18,20,22,25,26,null,0.41,"-",0.76,"D",0.74,"D",0.434,2,"-"]
[1089,"E","L","L",5,1,0,7,0,174,0,90,1,"b","e","b","e",18,8,74,7,7,9,12,15,18,21,24,26,27,null,0.47,"-",0.78,"D",0.54,"-",0.455,2,"-"]
[1090,"G","L","L",4,2,0,6,0,35,0,42,0,"b","e","b","e",23,8,72,11,11,13,16,18,20,21,21,21,20,null,0.56,"D",0.72,"D",0.56,"-",0.475,1,"-"]
[1091,"D","L","L",4,2,0,6,0,117,0,72,1,"b","e","b","e",26,9,70,7,7,9,12,15,18,21,23,24,24,null,0.47,"-",0.72,"D",0.61,"D",0.465,1,"-"]
[1092,"G","L","L",2,3,0,5,0,60,0,72,1,"b","e","b","e",36,8,62,8,8,10,13,15,19,22,23,24,24,null,0.45,"-",0.72,"D",0.55,"-",0.465,1,"-"]
[1093,"V","L","L",0,4,0,5,0,59,0,42,0,"b","e","b","e",45,7,53,11,12,14,16,18,20,21,21,20,19,null,0.36,"-",0.73,"D",0.58,"D",0.424,3,"-"]
[1094,"E","L","H",0,4,0,4,0,108,0,56,1,"b","e","b","e",48,9,48,10,11,12,15,17,20,22,23,22,20,null,0.36,"-",0.65,"D",0.51,"-",0.364,5,"-"]
[1095,"L","L","H",1,5,0,3,0,49,0,30,1,"b","e","b","i",59,6,41,16,16,17,19,20,21,20,17,15,13,null,0.31,"-",0.65,"D",0.58,"D",0.378,4,"-"]
[1096,"M","L","H",2,5,0,3,0,56,0,30,0,"b","e","b","i",62,8,34,14,14,15,18,19,20,20,19,17,15,null,0.23,"-",0.65,"D",0.35,"-",0.374,4,"-"]
[1097,"E","L","H",3,6,0,2,0,81,0,42,2,"b","e","b","e",68,7,29,12,12,14,16,20,23,24,23,19,17,null,0.23,"-",0.64,"D",0.26,"-",0.354,5,"-"]
[1098,"A","L","H",4,6,0,2,0,0,0,0,0,"b","b","b","b",72,6,27,23,22,21,21,19,17,14,12,10,9,null,0.21,"-",0.55,"D",0.24,"-",0.364,5,"-"]
[1099,"K","L","H",4,7,0,2,0,61,0,30,1,"b","e","b","i",74,6,25,16,16,15,17,20,21,21,18,14,12,null,0.16,"-",0.46,"-",0.25,"-",0.354,5,"-"]
[1100,"S","L","H",4,6,0,2,0,0,0,0,1,"b","b","b","b",69,5,27,25,23,20,19,18,16,14,11,9,8,null,0.15,"-",0.5,"D",0.26,"-",0.354,5,"-"]
[1101,"Q","L","H",5,7,0,1,0,59,0,30,1,"b","e","b","i",78,4,20,16,16,17,20,22,23,21,16,12,9,null,0.16,"-",0.52,"D",0.24,"-",0.374,4,"-"]
[1102,"L","L","H",6,7,0,1,0,0,0,0,1,"b","b","b","b",80,6,17,26,24,22,20,19,16,12,8,5,4,null,0.15,"-",0.36,"-",0.2,"-",0.343,5,"-"]
[1103,"F","L","H",6,7,0,1,0,0,0,0,6,"b","b","b","b",82,5,16,36,30,21,16,13,9,6,4,2,1,null,0.13,"-",0.34,"-",0.16,"-",0.323,6,"-"]
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[1105,"K","L","H",8,8,0,0,0,41,0,20,1,"b","e","b","i",90,3,10,17,18,18,22,24,24,19,13,7,4,null,0.11,"-",0.38,"-",0.13,"-",0.313,6,"-"]

{"sheet":"E28","index":24,"n_rows":56,"n_cols":40,"rows_kept":56,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
[1237,"D","L","H",5,7,0,1,0,68,0,42,2,"b","e","b","e",79,2,20,7,8,10,14,18,21,23,22,18,14,null,0.17,"-",0.57,"D",0.16,"-",0.253,8,"-"]
[1238,"E","L","H",7,8,0,1,0,58,0,30,2,"b","e","b","i",88,2,10,11,11,13,17,20,23,23,19,14,10,null,0.24,"-",0.56,"D",0.16,"-",0.253,8,"-"]
[1239,"L","L","H",8,9,0,0,0,0,0,0,7,"b","b","b","b",92,1,6,39,31,19,13,10,7,4,2,1,1,null,0.17,"-",0.4,"-",0.16,"-",0.25,9,"-"]
[1240,"A","L","H",8,9,0,0,0,0,0,0,5,"b","b","b","b",92,2,5,34,29,19,16,12,9,6,4,2,1,null,0.14,"-",0.36,"-",0.13,"-",0.242,9,"-"]
[1241,"R","L","H",8,9,0,0,0,74,0,30,2,"b","e","b","i",93,2,4,14,15,16,20,23,24,20,14,7,4,null,0.19,"-",0.41,"-",0.13,"-",0.242,9,"-"]
[1242,"V","L","H",8,9,0,0,0,0,0,0,5,"b","b","b","b",93,1,5,34,29,20,16,13,10,6,3,1,0,null,0.16,"-",0.23,"-",0.13,"-",0.242,9,"-"]
[1243,"L","L","H",9,9,0,0,0,0,0,0,9,"b","b","b","b",94,1,4,46,35,17,10,6,4,2,1,0,0,null,0.14,"-",0.2,"-",0.13,"-",0.242,9,"-"]
[1244,"V","L","H",9,9,0,0,0,0,0,0,6,"b","b","b","b",95,1,4,37,31,19,14,10,8,5,3,1,0,null,0.1,"-",0.25,"-",0.14,"-",0.25,9,"-"]
[1245,"T","L","H",8,8,0,0,0,0,0,0,1,"b","b","b","b",90,3,9,24,23,21,20,19,17,13,8,5,3,null,0.08,"-",0.28,"-",0.14,"-",0.253,8,"-"]
[1246,"L","L","H",7,8,0,1,0,0,0,0,7,"b","b","b","b",86,2,13,39,32,20,14,10,7,4,2,1,1,null,0.08,"-",0.28,"-",0.13,"-",0.253,8,"-"]
[1247,"F","L","H",6,7,0,1,0,0,0,0,4,"b","b","b","b",80,3,18,34,30,24,19,15,10,6,3,2,1,null,0.06,"-",0.35,"-",0.13,"-",0.253,8,"-"]
[1248,"D","L","H",3,6,0,3,0,48,0,30,2,"b","e","b","i",68,2,31,15,15,15,18,21,23,22,18,13,10,null,0.06,"-",0.54,"D",0.13,"-",0.263,8,"-"]
[1249,"S","L","H",1,5,0,4,0,0,0,0,1,"b","b","b","b",57,2,40,23,22,20,19,18,16,13,11,8,7,null,0.06,"-",0.52,"D",0.13,"-",0.263,8,"-"]
[1250,"R","L","H",2,5,0,3,0,49,0,20,1,"b","e","b","i",59,2,39,16,16,16,19,21,21,19,15,11,9,null,0.06,"-",0.52,"D",0.13,"-",0.253,8,"-"]
[1251,"H","L","H",4,7,0,2,0,55,0,30,1,"b","e","b","i",71,2,28,16,16,17,20,22,23,21,18,13,11,null,0.07,"-",0.55,"D",0.13,"-",0.253,8,"-"]
[1252,"L","L","H",6,7,0,1,0,0,0,0,0,"b","b","b","b",79,3,18,21,20,20,20,21,19,17,13,10,8,null,0.08,"-",0.47,"D",0.13,"-",0.242,9,"-"]
[1253,"L","L","H",7,8,0,1,0,0,0,0,5,"b","b","b","b",86,3,11,34,28,19,16,13,10,7,5,3,2,null,0.09,"-",0.4,"-",0.13,"-",0.242,9,"-"]
[1254,"Y","L","H",8,9,0,0,0,0,0,0,2,"b","b","b","b",91,1,6,27,25,21,19,17,14,11,7,3,2,null,0.09,"-",0.41,"-",0.15,"-",0.242,9,"-"]
[1255,"Q","L","H",8,9,0,0,0,59,0,30,1,"b","e","b","i",92,1,5,15,16,17,20,22,23,20,15,9,5,null,0.1,"-",0.41,"-",0.2,"-",0.25,9,"-"]
[1256,"L","L","H",8,9,0,0,0,0,0,0,4,"b","b","b","b",93,1,5,33,29,22,18,14,10,6,3,1,0,null,0.11,"-",0.3,"-",0.18,"-",0.242,9,"-"]
[1257,"L","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",93,2,5,46,35,16,9,6,4,2,1,0,0,null,0.07,"-",0.29,"-",0.13,"-",0.242,9,"-"]
[1258,"W","L","H",9,9,0,0,0,0,0,0,1,"b","b","b","b",94,1,4,23,22,19,19,18,16,13,9,5,3,null,0.06,"-",0.39,"-",0.14,"-",0.253,8,"-"]
[1259,"N","L","H",8,9,0,0,0,47,0,30,2,"b","e","b","i",92,1,7,12,13,15,19,23,24,22,16,9,5,null,0.08,"-",0.41,"-",0.14,"-",0.253,8,"-"]
[1260,"M","L","H",8,9,0,0,0,0,0,0,3,"b","b","b","b",92,1,7,31,28,22,19,16,12,7,4,2,1,null,0.09,"-",0.36,"-",0.14,"-",0.263,8,"-"]
[1261,"F","L","H",8,9,0,0,0,0,0,0,8,"b","b","b","b",93,2,5,40,32,18,13,9,6,4,2,1,0,null,0.12,"-",0.36,"-",0.14,"-",0.253,8,"-"]
[1262,"S","L","H",8,9,0,0,0,39,0,30,3,"b","e","b","i",92,1,6,10,11,13,17,20,24,24,20,13,8,null,0.13,"-",0.54,"D",0.17,"-",0.273,8,"-"]
[1263,"K","L","H",7,8,0,1,0,114,0,56,3,"b","e","b","e",89,1,10,3,4,6,9,14,20,26,27,22,17,null,0.15,"-",0.55,"D",0.27,"-",0.3,7,"-"]
[1264,"E","L","H",6,8,0,1,0,0,0,0,0,"b","b","b","b",83,1,15,22,21,21,21,19,16,12,9,6,4,null,0.13,"-",0.46,"-",0.28,"-",0.273,8,"-"]
[1265,"V","L","H",5,7,0,1,0,0,0,0,4,"b","b","b","b",77,4,20,33,29,22,18,14,10,7,4,3,2,null,0.21,"-",0.51,"D",0.28,"-",0.263,8,"-"]
[1266,"E","L","H",3,6,0,2,0,108,0,56,4,"b","e","b","e",68,6,31,4,5,6,9,14,19,25,28,25,21,null,0.19,"-",0.62,"D",0.47,"-",0.28,7,"-"]
[1267,"L","L","H",1,5,0,3,0,91,0,56,3,"b","e","b","e",55,7,41,5,6,8,12,15,19,23,25,24,22,null,0.18,"-",0.67,"D",0.44,"-",0.27,8,"-"]
[1268,"A","L","L",2,3,0,5,0,12,0,12,1,"b","b","b","i",34,8,61,18,19,21,22,21,18,15,12,10,9,null,0.22,"-",0.61,"D",0.23,"-",0.263,8,"-"]
[1269,"D","L","L",4,2,0,6,0,117,0,72,2,"b","e","b","e",24,9,72,5,5,7,9,13,18,22,26,27,27,null,0.27,"-",0.72,"D",0.15,"-",0.273,8,"-"]
[1270,"S","L","L",4,2,0,6,0,54,0,42,1,"b","e","b","e",24,10,71,9,9,11,14,17,21,23,23,21,19,null,0.32,"-",0.69,"D",0.19,"-",0.283,7,"-"]
[1271,"M","L","L",1,3,1,4,0,11,0,6,0,"b","b","b","b",41,17,52,20,20,21,21,20,18,15,13,12,11,null,0.3,"-",0.57,"D",0.16,"-",0.283,7,"-"]
[1272,"Q","L","L",1,3,1,4,0,59,0,30,1,"b","e","b","i",41,13,53,16,17,17,20,22,23,22,19,14,10,null,0.3,"-",0.52,"D",0.22,"-",0.29,7,"-"]
[1273,"T","L","H",0,4,1,3,0,0,0,0,0,"b","b","b","b",46,20,41,22,22,21,21,20,19,17,14,12,10,null,0.26,"-",0.49,"D",0.25,"-",0.283,7,"-"]
[1274,"L","L","H",0,4,2,3,0,0,0,0,3,"b","b","b","b",45,23,36,31,28,23,20,17,14,10,7,5,4,null,0.28,"-",0.41,"-",0.16,"-",0.273,8,"-"]
[1275,"F","L","H",0,3,2,3,0,0,0,0,4,"b","b","b","b",42,25,39,33,29,23,18,15,11,8,6,4,3,null,0.28,"-",0.43,"-",0.15,"-",0.273,8,"-"]
[1276,"R","L","L",0,3,2,4,0,0,0,0,0,"b","b","b","b",39,24,46,25,24,23,22,20,17,12,8,5,4,null,0.21,"-",0.39,"-",0.19,"-",0.283,7,"-"]
[1277,"G","L","L",2,3,1,5,0,0,0,0,2,"b","b","b","b",34,17,56,26,24,21,19,17,15,12,9,7,6,null,0.14,"-",0.39,"-",0.23,"-",0.293,7,"-"]
[1278,"N","L","L",2,3,1,5,0,0,0,0,1,"b","b","b","b",34,13,61,26,25,22,21,18,15,11,8,6,5,null,0.14,"-",0.32,"-",0.18,"-",0.293,7,"-"]
[1279,"S","L","H",0,4,0,4,0,0,0,0,1,"b","b","b","b",47,10,47,26,25,21,20,18,16,12,9,6,5,null,0.15,"-",0.39,"-",0.18,"-",0.293,7,"-"]
[1280,"L","L","H",4,6,0,2,0,0,0,0,1,"b","b","b","b",70,9,25,26,25,21,20,18,16,12,9,6,5,null,0.16,"-",0.39,"-",0.26,"-",0.283,7,"-"]
[1281,"A","L","H",5,7,0,1,0,0,0,0,5,"b","b","b","b",77,7,19,34,29,20,17,14,11,8,6,4,3,null,0.15,"-",0.33,"-",0.18,"-",0.263,8,"-"]
[1282,"S","L","H",7,8,0,1,0,0,0,0,3,"b","b","b","b",86,4,10,31,27,21,18,15,13,10,7,4,3,null,0.14,"-",0.34,"-",0.15,"-",0.26,8,"-"]
[1283,"K","L","H",8,8,0,0,0,41,0,20,1,"b","e","b","i",89,3,8,17,17,18,22,23,23,19,13,7,5,null,0.14,"-",0.28,"-",0.13,"-",0.26,8,"-"]
[1284,"I","L","H",8,8,0,0,0,0,0,0,6,"b","b","b","b",89,2,8,37,31,20,15,12,9,5,3,1,1,null,0.16,"-",0.28,"-",0.14,"-",0.253,8,"-"]
[1285,"M","L","H",8,9,0,0,0,0,0,0,7,"b","b","b","b",93,2,5,40,32,19,14,10,6,4,2,1,0,null,0.18,"-",0.3,"-",0.14,"-",0.253,8,"-"]
[1286,"T","L","H",8,9,0,0,0,42,0,30,1,"b","e","b","i",93,1,5,16,16,16,18,20,22,21,16,10,5,null,0.13,"-",0.38,"-",0.13,"-",0.28,7,"-"]
[1287,"F","L","H",8,9,0,0,0,23,0,12,0,"b","b","b","i",94,1,5,21,21,21,22,21,17,13,8,5,3,null,0.12,"-",0.34,"-",0.13,"-",0.263,8,"-"]
[1288,"C","L","H",8,9,0,0,0,0,0,0,4,"b","b","b","b",92,1,7,34,30,22,18,14,10,6,4,2,1,null,0.09,"-",0.33,"-",0.13,"-",0.27,8,"-"]
[1289,"F","L","H",7,8,0,1,0,0,0,0,2,"b","b","b","b",87,2,12,27,25,22,20,17,14,11,8,6,4,null,0.09,"-",0.46,"-",0.13,"-",0.253,8,"-"]
[1290,"K","L","H",5,7,0,2,0,61,0,30,2,"b","e","b","i",77,2,23,14,14,15,18,20,22,22,19,14,11,null,0.07,"-",0.52,"D",0.13,"-",0.253,8,"-"]

{"sheet":"E36","index":25,"n_rows":39,"n_cols":40,"rows_kept":39,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
[1555,"H","L","H",1,4,1,3,0,0,0,0,0,"b","b","b","b",50,19,35,22,22,21,21,19,17,14,12,10,9,null,0.24,"-",0.53,"D",0.45,"-",0.414,3,"-"]
[1556,"Q","L","H",1,4,1,3,0,59,0,30,1,"b","e","b","i",49,17,38,14,14,15,18,20,21,21,20,17,15,null,0.24,"-",0.54,"D",0.69,"D",0.465,1,"-"]
[1557,"V","L","H",1,4,1,3,0,28,0,20,0,"b","e","b","i",50,19,38,15,15,17,19,20,20,20,19,17,16,null,0.23,"-",0.56,"D",0.65,"D",0.465,1,"-"]
[1558,"H","L","H",0,4,1,3,0,36,0,20,0,"b","e","b","i",45,20,41,15,15,16,19,21,21,20,18,16,14,null,0.23,"-",0.56,"D",0.79,"D",0.485,1,"-"]
[1559,"E","L","H",0,4,1,3,0,58,0,30,1,"b","e","b","i",45,19,41,13,13,15,17,20,22,22,20,18,16,null,0.23,"-",0.57,"D",0.74,"D",0.465,1,"-"]
[1560,"K","L","H",0,4,1,3,0,86,0,42,1,"b","e","b","e",47,18,42,12,12,14,16,19,21,22,22,20,18,null,0.25,"-",0.59,"D",0.61,"D",0.459,2,"-"]
[1561,"E","L","H",0,4,1,3,0,108,0,56,1,"b","e","b","e",47,19,41,7,8,10,14,17,19,21,23,23,23,null,0.21,"-",0.6,"D",0.72,"D",0.48,1,"-"]
[1562,"E","L","H",0,4,1,3,0,108,0,56,3,"b","e","b","e",45,20,43,5,5,7,10,14,19,24,27,26,24,null,0.19,"-",0.59,"D",0.81,"D",0.455,2,"-"]
[1563,"F","L","L",1,3,2,4,0,11,0,6,1,"b","b","b","b",35,25,49,19,20,21,21,19,17,14,11,11,10,null,0.18,"-",0.59,"D",0.7,"D",0.404,3,"-"]
[1564,"K","L","L",1,2,2,4,0,114,0,56,3,"b","e","b","e",31,27,49,6,6,7,10,13,17,21,24,23,22,null,0.15,"-",0.59,"D",0.65,"D",0.37,5,"-"]
[1565,"A","L","L",1,2,2,4,0,44,0,42,0,"b","e","b","e",31,31,46,11,11,12,15,18,21,22,22,20,19,null,0.14,"-",0.59,"D",0.37,"-",0.323,6,"-"]
[1566,"L","L","L",0,2,3,3,0,19,0,12,0,"b","b","b","i",31,35,42,18,19,20,21,20,17,15,13,12,11,null,0.13,"-",0.57,"D",0.23,"-",0.293,7,"-"]
[1567,"K","L","L",0,2,3,3,0,114,0,56,2,"b","e","b","e",29,36,43,8,8,9,12,15,19,22,23,22,20,null,0.11,"-",0.57,"D",0.16,"-",0.303,7,"-"]
[1568,"T","L","E",0,2,3,3,0,42,0,30,1,"b","e","b","i",30,39,38,14,14,15,18,19,21,21,19,16,13,null,0.11,"-",0.56,"D",0.22,"-",0.293,7,"-"]
[1569,"L","L","E",0,2,4,3,0,9,0,6,1,"b","b","b","b",23,43,39,21,21,22,22,20,18,15,12,9,8,null,0.1,"-",0.52,"D",0.17,"-",0.29,7,"-"]
[1570,"S","L","E",1,1,4,3,0,26,0,20,1,"b","e","b","i",19,51,34,16,17,19,22,23,23,20,15,11,8,null,0.12,"-",0.47,"D",0.17,"-",0.293,7,"-"]
[1571,"I","L","E",4,1,6,2,0,0,0,0,2,"b","b","b","b",14,65,24,28,26,22,20,17,15,11,7,4,3,null,0.14,"-",0.4,"-",0.22,"-",0.283,7,"-"]
[1572,"F","L","E",6,1,7,1,0,0,0,0,0,"b","b","b","b",11,76,16,24,23,21,21,19,17,13,10,7,5,null,0.13,"-",0.36,"-",0.18,"-",0.273,8,"-"]
[1573,"Y","L","E",5,1,6,1,0,0,0,0,1,"b","b","b","b",13,74,19,25,24,21,20,18,16,13,9,6,4,null,0.16,"-",0.35,"-",0.22,"-",0.283,7,"-"]
[1574,"Q","L","E",4,1,6,2,0,39,0,20,1,"b","e","b","i",13,69,22,18,18,19,22,23,23,20,16,12,9,null,0.15,"-",0.34,"-",0.3,"-",0.293,7,"-"]
[1575,"A","L","E",2,1,5,3,0,0,0,0,0,"b","b","b","b",12,57,36,22,21,21,21,21,19,16,13,10,9,null,0.14,"-",0.41,"-",0.27,"-",0.293,7,"-"]
[1576,"G","L","E",1,1,4,3,0,0,0,0,0,"b","b","b","b",12,53,42,21,20,19,20,20,19,16,14,12,11,null,0.12,"-",0.48,"D",0.37,"-",0.303,7,"-"]
[1577,"T","L","E",0,1,4,4,0,42,0,30,1,"b","e","b","i",12,51,43,14,15,16,19,20,22,21,19,16,14,null,0.1,"-",0.54,"D",0.56,"-",0.303,7,"-"]
[1578,"S","L","L",1,1,3,4,0,39,0,30,0,"b","e","b","i",18,35,51,14,15,16,18,20,21,21,19,18,17,null,0.11,"-",0.57,"D",0.57,"-",0.303,7,"-"]
[1579,"K","L","L",3,1,2,5,0,147,0,72,2,"b","e","b","e",17,27,58,6,6,8,11,14,18,21,24,27,27,null,0.1,"-",0.59,"D",0.37,"-",0.283,7,"-"]
[1580,"A","L","L",5,1,1,7,0,44,0,42,0,"b","e","b","e",11,18,75,10,10,12,15,17,20,21,21,21,21,null,0.09,"-",0.65,"D",0.28,"-",0.273,8,"-"]
[1581,"G","L","L",6,0,1,7,0,25,0,30,0,"b","e","b","i",6,16,80,14,14,15,17,19,20,20,20,19,17,null,0.09,"-",0.59,"D",0.22,"-",0.27,8,"-"]
[1582,"N","L","L",4,0,2,6,0,31,0,20,1,"b","e","b","i",4,28,71,15,17,19,22,23,22,19,15,10,7,null,0.09,"-",0.51,"D",0.18,"-",0.253,8,"-"]
[1583,"P","L","E",2,0,5,3,0,0,0,0,2,"b","b","b","b",4,60,40,28,27,23,21,18,15,11,7,4,3,null,0.1,"-",0.4,"-",0.17,"-",0.242,9,"-"]
[1584,"I","L","E",7,0,8,1,0,0,0,0,6,"b","b","b","b",3,85,13,37,31,21,16,12,9,5,3,1,0,null,0.1,"-",0.24,"-",0.15,"-",0.24,9,"-"]
[1585,"F","L","E",8,0,9,0,0,0,0,0,8,"b","b","b","b",3,90,6,41,34,20,13,9,7,4,2,1,0,null,0.12,"-",0.19,"-",0.16,"-",0.24,9,"-"]
[1586,"Y","L","E",8,0,9,0,0,0,0,0,7,"b","b","b","b",3,92,5,39,32,19,14,10,7,4,2,1,0,null,0.14,"-",0.17,"-",0.14,"-",0.24,9,"-"]
[1587,"Y","L","E",8,0,8,0,0,0,0,0,7,"b","b","b","b",3,89,8,39,32,21,15,11,8,5,2,1,1,null,0.15,"-",0.17,"-",0.15,"-",0.242,9,"-"]
[1588,"V","L","E",6,0,8,1,0,0,0,0,6,"b","b","b","b",6,82,13,36,30,20,16,12,9,6,3,2,1,null,0.14,"-",0.2,"-",0.14,"-",0.242,9,"-"]
[1589,"A","L","E",4,1,6,2,0,0,0,0,4,"b","b","b","b",12,65,25,33,28,21,17,14,10,7,5,3,3,null,0.1,"-",0.29,"-",0.16,"-",0.253,8,"-"]
[1590,"R","L","E",1,1,5,3,0,49,0,20,1,"b","e","b","i",15,53,36,18,18,19,21,22,22,19,15,11,8,null,0.07,"-",0.42,"-",0.23,"-",0.28,7,"-"]
[1591,"R","L","L",0,1,4,4,0,74,0,30,2,"b","e","b","i",17,44,45,11,12,16,20,23,24,21,17,13,10,null,0.11,"-",0.48,"D",0.23,"-",0.283,7,"-"]

{"sheet":"E41","index":26,"n_rows":49,"n_cols":40,"rows_kept":49,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
[1982,"I","L","L",5,2,0,7,0,20,0,12,1,"b","b","b","i",21,4,75,17,18,20,21,21,18,15,12,10,9,null,0.09,"-",0.65,"D",0.17,"-",0.263,8,"-"]
[1983,"T","L","L",5,2,0,7,0,42,0,30,0,"b","e","b","i",24,5,76,13,13,14,17,19,21,21,20,18,16,null,0.12,"-",0.7,"D",0.14,"-",0.263,8,"-"]
[1984,"D","L","L",3,3,0,6,0,91,0,56,3,"b","e","b","e",33,5,68,5,5,6,9,13,18,23,26,26,26,null,0.15,"-",0.59,"D",0.15,"-",0.263,8,"-"]
[1985,"L","L","H",1,5,0,3,0,0,0,0,0,"b","b","b","b",56,8,39,23,23,22,21,20,18,15,11,8,7,null,0.15,"-",0.47,"D",0.16,"-",0.253,8,"-"]
[1986,"L","L","H",2,5,0,3,0,0,0,0,3,"b","b","b","b",61,8,33,30,27,21,18,15,12,9,6,3,2,null,0.13,"-",0.39,"-",0.16,"-",0.242,9,"-"]
[1987,"D","L","H",5,7,0,2,0,48,0,30,1,"b","e","b","i",74,6,21,13,14,16,19,21,22,20,16,11,7,null,0.14,"-",0.42,"-",0.16,"-",0.242,9,"-"]
[1988,"V","L","H",7,8,0,1,0,0,0,0,1,"b","b","b","b",82,7,12,25,24,22,21,19,16,11,7,4,2,null,0.13,"-",0.3,"-",0.14,"-",0.25,9,"-"]
[1989,"V","L","H",7,8,0,0,0,0,0,0,9,"b","b","b","b",86,6,10,43,34,18,11,8,5,3,1,0,0,null,0.13,"-",0.25,"-",0.15,"-",0.242,9,"-"]
[1990,"L","L","H",8,9,0,0,0,0,0,0,7,"b","b","b","b",92,2,7,39,32,19,14,10,7,4,2,1,0,null,0.09,"-",0.32,"-",0.18,"-",0.253,8,"-"]
[1991,"D","L","H",8,9,0,0,0,32,0,20,2,"b","e","b","i",94,1,5,16,17,19,22,24,24,20,14,7,4,null,0.07,"-",0.36,"-",0.25,"-",0.273,8,"-"]
[1992,"S","L","H",8,9,0,0,0,0,0,0,0,"b","b","b","b",94,1,5,22,22,22,22,21,17,12,7,4,2,null,0.09,"-",0.34,"-",0.21,"-",0.273,8,"-"]
[1993,"F","L","H",9,9,0,0,0,0,0,0,9,"b","b","b","b",95,1,3,45,35,17,10,6,4,2,1,0,0,null,0.1,"-",0.28,"-",0.26,"-",0.27,8,"-"]
[1994,"I","L","H",9,9,0,0,0,0,0,0,6,"b","b","b","b",95,2,3,38,32,20,15,11,7,4,2,1,0,null,0.11,"-",0.29,"-",0.31,"-",0.273,8,"-"]
[1995,"K","L","H",8,9,0,0,0,61,0,30,2,"b","e","b","i",94,1,5,12,13,15,19,21,24,22,18,11,7,null,0.1,"-",0.4,"-",0.42,"-",0.3,7,"-"]
[1996,"T","L","H",7,8,0,1,0,17,0,12,0,"b","b","b","i",88,2,11,20,21,22,23,22,19,14,9,5,3,null,0.14,"-",0.32,"-",0.25,"-",0.283,7,"-"]
[1997,"S","L","H",6,8,0,1,0,0,0,0,7,"b","b","b","b",84,4,15,40,32,20,14,12,8,5,3,2,1,null,0.16,"-",0.34,"-",0.22,"-",0.283,7,"-"]
[1998,"A","L","H",4,7,0,2,0,0,0,0,1,"b","b","b","b",72,5,25,26,24,22,20,18,16,13,10,8,7,null,0.18,"-",0.47,"D",0.34,"-",0.293,7,"-"]
[1999,"T","L","H",2,5,0,3,0,79,0,56,1,"b","e","b","e",61,7,35,11,12,13,15,17,20,21,22,20,18,null,0.17,"-",0.59,"D",0.33,"-",0.303,7,"-"]
[2000,"G","L","L",2,3,0,5,0,25,0,30,2,"b","e","b","i",39,5,59,9,10,14,19,22,24,23,20,17,14,null,0.16,"-",0.64,"D",0.33,"-",0.293,7,"-"]
[2001,"G","L","L",4,2,0,6,0,47,0,56,3,"b","e","b","e",27,5,72,8,8,9,12,15,19,22,25,25,25,null,0.22,"-",0.68,"D",0.3,"-",0.3,7,"-"]
[2002,"L","L","L",5,2,0,7,0,19,0,12,2,"b","b","b","i",21,8,74,15,18,22,24,22,18,14,12,11,11,null,0.22,"-",0.7,"D",0.34,"-",0.273,8,"-"]
[2003,"G","L","L",5,1,0,7,0,60,0,72,2,"b","e","b","e",16,10,75,6,6,8,11,15,19,22,25,27,27,null,0.22,"-",0.71,"D",0.27,"-",0.27,8,"-"]
[2004,"S","L","L",5,2,0,7,0,93,0,72,1,"b","e","b","e",21,9,75,9,10,11,14,16,19,21,22,23,23,null,0.23,"-",0.64,"D",0.21,"-",0.263,8,"-"]
[2005,"I","L","L",3,2,1,6,0,33,0,20,1,"b","e","b","i",29,12,62,13,14,17,20,21,21,19,17,15,13,null,0.24,"-",0.59,"D",0.2,"-",0.263,8,"-"]
[2006,"K","L","L",1,3,1,5,0,86,0,42,2,"b","e","b","e",39,11,54,9,9,11,15,18,22,23,21,16,13,null,0.22,"-",0.56,"D",0.25,"-",0.273,8,"-"]
[2007,"A","L","H",3,6,0,2,0,12,0,12,0,"b","b","b","i",63,10,29,22,22,22,23,21,18,14,11,8,6,null,0.21,"-",0.49,"D",0.34,"-",0.283,7,"-"]
[2008,"E","L","H",5,7,1,1,0,108,0,56,2,"b","e","b","e",72,11,19,7,8,9,12,16,19,23,24,21,18,null,0.17,"-",0.48,"D",0.33,"-",0.29,7,"-"]
[2009,"V","L","H",6,7,1,1,0,0,0,0,0,"b","b","b","b",76,12,15,24,23,22,22,21,18,14,10,6,4,null,0.16,"-",0.41,"-",0.24,"-",0.273,8,"-"]
[2010,"M","L","H",6,7,1,1,0,0,0,0,6,"b","b","b","b",81,11,13,36,30,21,16,13,9,6,4,3,2,null,0.13,"-",0.34,"-",0.3,"-",0.27,8,"-"]
[2011,"A","L","H",6,7,0,1,0,31,0,30,1,"b","e","b","i",82,7,15,17,17,17,19,20,21,19,16,11,8,null,0.09,"-",0.42,"-",0.17,"-",0.273,8,"-"]
[2012,"D","L","H",5,7,0,1,0,32,0,20,1,"b","e","b","i",75,9,18,17,18,19,22,23,23,19,15,10,7,null,0.12,"-",0.39,"-",0.17,"-",0.27,8,"-"]
[2013,"T","L","H",5,7,1,1,0,0,0,0,6,"b","b","b","b",73,14,17,37,30,19,14,11,8,5,3,2,1,null,0.11,"-",0.28,"-",0.15,"-",0.263,8,"-"]
[2014,"A","L","H",5,6,1,1,0,0,0,0,7,"b","b","b","b",72,21,14,37,30,18,13,10,7,5,4,2,1,null,0.12,"-",0.27,"-",0.18,"-",0.263,8,"-"]
[2015,"V","L","H",4,6,2,1,0,0,0,0,4,"b","b","b","b",68,27,14,31,27,19,16,13,11,9,7,4,3,null,0.11,"-",0.28,"-",0.24,"-",0.26,8,"-"]
[2016,"A","L","H",4,6,2,1,0,0,0,0,4,"b","b","b","b",68,28,14,32,28,20,17,14,11,8,6,4,3,null,0.1,"-",0.2,"-",0.2,"-",0.263,8,"-"]
[2017,"L","L","H",3,5,2,1,0,0,0,0,7,"b","b","b","b",65,30,16,40,33,21,15,11,7,4,3,2,1,null,0.1,"-",0.19,"-",0.22,"-",0.263,8,"-"]
[2018,"A","L","H",3,5,2,2,0,0,0,0,5,"b","b","b","b",58,25,23,34,29,21,16,13,10,8,6,4,4,null,0.09,"-",0.23,"-",0.17,"-",0.283,7,"-"]
[2019,"S","L","H",1,4,2,3,0,0,0,0,3,"b","b","b","b",48,21,36,29,26,20,17,15,12,9,7,6,5,null,0.1,"-",0.33,"-",0.15,"-",0.293,7,"-"]
[2020,"G","L","L",1,3,1,4,0,0,0,0,1,"b","b","b","b",35,18,50,24,23,21,20,18,15,12,8,6,5,null,0.11,"-",0.37,"-",0.18,"-",0.323,6,"-"]
[2021,"N","L","L",3,2,1,5,0,0,0,0,0,"b","b","b","b",27,17,60,20,19,18,18,18,17,15,13,11,9,null,0.12,"-",0.39,"-",0.2,"-",0.323,6,"-"]
[2022,"V","L","L",2,3,1,5,0,0,0,0,0,"b","b","b","b",33,13,59,23,22,21,20,19,17,15,12,10,8,null,0.13,"-",0.43,"-",0.38,"-",0.333,6,"-"]
[2023,"K","L","L",0,4,0,4,0,61,0,30,1,"b","e","b","i",45,9,49,13,13,14,17,19,21,21,19,17,15,null,0.12,"-",0.47,"D",0.31,"-",0.313,6,"-"]
[2024,"L","L","H",2,5,1,3,0,49,0,30,1,"b","e","b","i",59,11,32,16,17,17,19,20,21,19,17,15,14,null,0.14,"-",0.56,"D",0.21,"-",0.283,7,"-"]
[2025,"V","L","H",3,5,1,3,0,0,0,0,2,"b","b","b","b",61,11,31,29,27,22,20,18,14,11,8,5,4,null,0.14,"-",0.44,"-",0.2,"-",0.273,8,"-"]
[2026,"S","L","H",4,6,0,2,0,0,0,0,4,"b","b","b","b",69,6,28,31,27,19,17,15,12,9,6,4,3,null,0.11,"-",0.4,"-",0.2,"-",0.263,8,"-"]
[2027,"S","L","H",7,8,0,1,0,0,0,0,1,"b","b","b","b",85,3,14,23,21,19,18,18,17,14,11,8,6,null,0.12,"-",0.43,"-",0.2,"-",0.263,8,"-"]
[2028,"K","L","H",8,8,0,0,0,61,0,30,3,"b","e","b","i",90,3,9,11,12,14,19,22,24,22,16,10,6,null,0.15,"-",0.43,"-",0.14,"-",0.253,8,"-"]

{"sheet":"E46","index":27,"n_rows":36,"n_cols":40,"rows_kept":36,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
[2253,"A","L","H",4,6,0,2,0,0,0,0,1,"b","b","b","b",70,5,26,27,25,22,21,19,15,10,7,4,3,null,0.21,"-",0.35,"-",0.2,"-",0.303,7,"-"]
[2254,"L","L","H",4,6,0,2,0,0,0,0,7,"b","b","b","b",72,7,26,39,31,19,13,10,7,4,3,2,2,null,0.26,"-",0.4,"-",0.26,"-",0.303,7,"-"]
[2255,"E","L","H",2,5,0,3,0,108,0,56,2,"b","e","b","e",61,6,40,7,8,9,12,16,19,23,24,22,20,null,0.27,"-",0.54,"D",0.41,"-",0.343,5,"-"]
[2256,"S","L","H",0,4,0,4,0,54,0,42,2,"b","e","b","e",50,8,47,7,8,11,15,19,23,25,24,20,17,null,0.28,"-",0.61,"D",0.46,"-",0.333,6,"-"]
[2257,"C","L","L",0,4,1,4,0,16,0,12,1,"b","b","b","i",44,12,52,17,18,20,22,22,19,15,12,10,9,null,0.25,"-",0.64,"D",0.33,"-",0.293,7,"-"]
[2258,"L","L","L",2,3,1,5,0,49,0,30,1,"b","e","b","i",37,11,61,13,14,16,19,21,22,21,20,18,16,null,0.28,"-",0.67,"D",0.26,"-",0.303,7,"-"]
[2259,"K","L","L",3,2,1,5,0,184,0,90,2,"b","e","b","e",32,12,65,4,4,6,10,14,17,21,25,27,28,null,0.33,"-",0.7,"D",0.4,"-",0.364,5,"-"]
[2260,"G","L","L",3,2,0,6,0,75,0,90,1,"b","e","b","e",30,9,67,7,8,9,12,14,18,21,24,26,27,null,0.25,"-",0.69,"D",0.36,"-",0.343,5,"-"]
[2261,"P","L","L",3,2,0,6,0,16,0,12,1,"b","b","b","i",32,9,66,16,17,19,21,20,18,16,15,14,13,null,0.29,"-",0.66,"D",0.37,"-",0.303,7,"-"]
[2262,"D","L","L",3,2,0,6,0,91,0,56,2,"b","e","b","e",32,9,67,7,7,9,12,16,19,22,23,23,22,null,0.23,"-",0.62,"D",0.39,"-",0.323,6,"-"]
[2263,"T","L","L",2,3,1,5,0,42,0,30,0,"b","e","b","i",37,11,60,13,13,14,17,18,20,20,19,17,15,null,0.21,"-",0.61,"D",0.39,"-",0.303,7,"-"]
[2264,"Y","L","L",0,4,1,4,0,26,0,12,1,"b","b","b","i",43,12,50,19,21,22,23,21,18,13,11,9,8,null,0.19,"-",0.57,"D",0.21,"-",0.273,8,"-"]
[2265,"N","L","L",0,4,0,4,0,47,0,30,1,"b","e","b","i",44,10,53,14,14,15,17,19,21,20,17,14,12,null,0.17,"-",0.57,"D",0.26,"-",0.283,7,"-"]
[2266,"S","L","H",0,4,0,4,0,0,0,0,0,"b","b","b","b",52,8,46,23,23,21,21,19,17,14,10,7,5,null,0.19,"-",0.48,"D",0.23,"-",0.293,7,"-"]
[2267,"Q","L","H",3,6,0,2,0,0,0,0,1,"b","b","b","b",64,10,31,24,23,21,20,19,17,14,11,8,7,null,0.15,"-",0.42,"-",0.19,"-",0.263,8,"-"]
[2268,"V","L","H",5,7,1,1,0,0,0,0,2,"b","b","b","b",70,11,19,27,25,21,20,18,15,11,8,5,4,null,0.19,"-",0.38,"-",0.16,"-",0.263,8,"-"]
[2269,"L","L","H",6,7,0,1,0,0,0,0,5,"b","b","b","b",79,10,12,35,31,23,18,14,10,6,3,1,0,null,0.15,"-",0.26,"-",0.16,"-",0.263,8,"-"]
[2270,"I","L","H",7,8,0,0,0,0,0,0,7,"b","b","b","b",87,6,8,39,33,20,15,10,7,4,2,1,0,null,0.11,"-",0.21,"-",0.15,"-",0.263,8,"-"]
[2271,"E","L","H",8,9,0,0,0,0,0,0,4,"b","b","b","b",91,3,6,33,30,22,18,14,11,7,3,1,0,null,0.11,"-",0.21,"-",0.13,"-",0.273,8,"-"]
[2272,"A","L","H",8,9,0,0,0,0,0,0,6,"b","b","b","b",93,2,4,37,31,20,15,11,8,5,3,1,1,null,0.09,"-",0.21,"-",0.13,"-",0.273,8,"-"]
[2273,"T","L","H",9,9,0,0,0,0,0,0,9,"b","b","b","b",94,1,4,43,34,18,12,8,5,3,1,0,0,null,0.09,"-",0.17,"-",0.15,"-",0.293,7,"-"]
[2274,"V","L","H",9,9,0,0,0,0,0,0,9,"b","b","b","b",96,1,3,44,35,18,11,7,4,2,1,0,0,null,0.06,"-",0.2,"-",0.15,"-",0.303,7,"-"]
[2275,"I","L","H",9,9,0,0,0,0,0,0,3,"b","b","b","b",94,2,4,30,27,22,19,15,11,7,4,2,1,null,0.07,"-",0.27,"-",0.21,"-",0.303,7,"-"]
[2276,"A","L","H",8,9,0,0,0,0,0,0,6,"b","b","b","b",93,2,7,37,31,19,15,11,8,5,3,1,1,null,0.1,"-",0.2,"-",0.19,"-",0.303,7,"-"]
[2277,"L","L","H",9,9,0,0,0,0,0,0,7,"b","b","b","b",95,1,4,40,33,20,14,10,6,4,2,1,0,null,0.12,"-",0.23,"-",0.16,"-",0.293,7,"-"]
[2278,"T","L","H",8,9,0,0,0,0,0,0,2,"b","b","b","b",91,2,7,27,25,21,19,17,15,11,7,4,3,null,0.13,"-",0.33,"-",0.13,"-",0.283,7,"-"]
[2279,"K","L","H",7,8,0,0,0,41,0,20,2,"b","e","b","i",89,2,10,15,15,17,21,24,24,21,15,9,5,null,0.15,"-",0.42,"-",0.16,"-",0.323,6,"-"]
[2280,"L","L","H",7,8,0,1,0,0,0,0,6,"b","b","b","b",87,2,11,36,29,18,13,10,7,5,3,2,1,null,0.22,"-",0.37,"-",0.26,"-",0.323,6,"-"]
[2281,"Q","L","H",7,8,0,1,0,0,0,0,3,"b","b","b","b",86,3,13,29,26,21,19,17,14,11,8,5,4,null,0.2,"-",0.46,"-",0.33,"-",0.323,6,"-"]
[2282,"P","L","H",4,6,0,2,0,97,0,72,3,"b","e","b","e",71,4,28,6,6,7,9,12,16,22,27,28,27,null,0.2,"-",0.59,"D",0.5,"-",0.354,5,"-"]
[2283,"L","L","H",1,5,0,4,0,49,0,30,1,"b","e","b","i",55,4,45,8,9,12,17,21,23,23,21,17,14,null,0.16,"-",0.67,"D",0.54,"-",0.323,6,"-"]
[2284,"L","L","L",4,2,0,6,0,9,0,6,3,"b","b","b","b",26,6,70,24,25,26,24,21,15,10,6,5,4,null,0.18,"-",0.68,"D",0.28,"-",0.283,7,"-"]
[2285,"N","L","L",6,1,0,7,0,65,0,42,1,"b","e","b","e",17,6,79,8,9,10,13,18,22,25,25,22,20,null,0.18,"-",0.71,"D",0.37,"-",0.337,6,"-"]
[2286,"K","L","L",4,2,0,6,0,184,0,90,1,"b","e","b","e",27,7,70,6,7,8,11,14,17,20,22,24,25,null,0.18,"-",0.69,"D",0.46,"-",0.374,4,"-"]

{"sheet":"E47","index":28,"n_rows":49,"n_cols":40,"rows_kept":49,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
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[2288,"S","L","L",2,3,0,5,0,39,0,30,1,"b","e","b","i",35,7,61,14,15,16,19,20,21,20,18,16,15,null,0.18,"-",0.67,"D",0.41,"-",0.32,6,"-"]
[2289,"P","L","L",1,3,1,5,0,40,0,30,1,"b","e","b","i",39,11,53,15,16,17,20,21,22,20,17,14,11,null,0.2,"-",0.61,"D",0.42,"-",0.293,7,"-"]
[2290,"L","L","L",0,4,1,4,0,0,0,0,0,"b","b","b","b",44,12,46,26,25,23,23,20,17,12,8,5,4,null,0.22,"-",0.48,"D",0.28,"-",0.273,8,"-"]
[2291,"H","L","H",1,5,1,3,0,0,0,0,2,"b","b","b","b",55,11,38,30,28,23,21,18,14,9,5,3,2,null,0.19,"-",0.36,"-",0.17,"-",0.253,8,"-"]
[2292,"K","L","H",4,6,0,2,0,0,0,0,2,"b","b","b","b",72,8,24,28,26,21,19,17,15,11,7,4,3,null,0.13,"-",0.4,"-",0.15,"-",0.25,9,"-"]
[2293,"A","L","H",6,7,0,1,0,0,0,0,3,"b","b","b","b",80,7,15,30,27,21,18,15,12,8,5,3,2,null,0.11,"-",0.24,"-",0.13,"-",0.242,9,"-"]
[2294,"L","L","H",7,8,0,1,0,0,0,0,8,"b","b","b","b",83,7,11,42,35,20,14,9,5,3,1,0,0,null,0.12,"-",0.24,"-",0.13,"-",0.242,9,"-"]
[2295,"F","L","H",7,8,0,0,0,0,0,0,9,"b","b","b","b",85,6,10,44,35,19,12,8,5,3,1,0,0,null,0.11,"-",0.23,"-",0.13,"-",0.242,9,"-"]
[2296,"W","L","H",8,9,0,0,0,0,0,0,6,"b","b","b","b",91,4,6,37,32,23,17,12,8,4,2,1,0,null,0.11,"-",0.14,"-",0.13,"-",0.253,8,"-"]
[2297,"V","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",92,3,5,41,32,17,11,8,5,3,2,1,0,null,0.1,"-",0.12,"-",0.13,"-",0.253,8,"-"]
[2298,"A","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",92,3,5,45,34,14,8,6,4,2,1,0,0,null,0.1,"-",0.1,"-",0.15,"-",0.25,9,"-"]
[2299,"V","L","H",8,9,0,0,0,0,0,0,8,"b","b","b","b",91,5,5,40,32,18,12,8,6,4,2,1,0,null,0.09,"-",0.18,"-",0.13,"-",0.253,8,"-"]
[2300,"A","L","H",8,8,0,0,0,0,0,0,9,"b","b","b","b",88,5,8,42,32,16,10,7,5,3,2,1,0,null,0.04,"-",0.12,"-",0.14,"-",0.263,8,"-"]
[2301,"V","L","H",7,8,0,0,0,0,0,0,6,"b","b","b","b",86,5,10,35,29,20,15,11,8,6,4,2,1,null,0.06,"-",0.2,"-",0.15,"-",0.27,8,"-"]
[2302,"L","L","H",6,8,0,1,0,0,0,0,2,"b","b","b","b",81,5,15,29,26,22,20,17,14,10,6,4,3,null,0.08,"-",0.23,"-",0.18,"-",0.273,8,"-"]
[2303,"Q","L","H",3,6,0,3,0,0,0,0,0,"b","b","b","b",63,8,32,20,19,18,18,18,18,16,13,10,8,null,0.08,"-",0.41,"-",0.15,"-",0.26,8,"-"]
[2304,"L","L","L",2,3,0,5,0,0,0,0,1,"b","b","b","b",36,6,59,24,23,21,18,16,14,11,8,5,4,null,0.1,"-",0.42,"-",0.14,"-",0.263,8,"-"]
[2305,"D","L","L",4,2,0,6,0,91,0,56,2,"b","e","b","e",27,4,68,7,7,9,12,16,20,22,23,21,20,null,0.11,"-",0.54,"D",0.15,"-",0.263,8,"-"]
[2306,"E","L","L",5,2,0,7,0,81,0,42,2,"b","e","b","e",23,3,75,9,9,11,15,19,22,23,21,17,14,null,0.11,"-",0.53,"D",0.17,"-",0.293,7,"-"]
[2307,"V","L","H",1,5,0,3,0,17,0,12,1,"b","b","b","i",57,4,39,19,20,22,23,21,18,16,13,10,8,null,0.1,"-",0.52,"D",0.22,"-",0.283,7,"-"]
[2308,"N","L","H",4,6,0,2,0,47,0,30,1,"b","e","b","i",71,4,27,15,15,16,19,21,22,20,17,12,9,null,0.12,"-",0.41,"-",0.2,"-",0.273,8,"-"]
[2309,"L","L","H",7,8,0,1,0,0,0,0,1,"b","b","b","b",84,3,12,24,23,21,20,19,18,14,10,6,4,null,0.14,"-",0.41,"-",0.26,"-",0.253,8,"-"]
[2310,"Y","L","H",8,8,0,0,0,0,0,0,4,"b","b","b","b",88,3,8,35,31,23,19,15,10,5,2,1,0,null,0.1,"-",0.34,"-",0.16,"-",0.242,9,"-"]
[2311,"S","L","H",8,9,0,0,0,0,0,0,1,"b","b","b","b",91,2,6,25,23,21,20,19,16,12,8,4,3,null,0.1,"-",0.35,"-",0.13,"-",0.242,9,"-"]
[2312,"A","L","H",8,9,0,0,0,0,0,0,2,"b","b","b","b",91,2,7,26,24,20,19,18,16,12,8,4,3,null,0.14,"-",0.36,"-",0.15,"-",0.242,9,"-"]
[2313,"G","L","H",8,9,0,0,0,0,0,0,9,"b","b","b","b",93,1,5,44,33,15,9,6,4,3,2,1,0,null,0.1,"-",0.2,"-",0.16,"-",0.25,9,"-"]
[2314,"T","L","H",9,9,0,0,0,0,0,0,6,"b","b","b","b",94,1,4,36,30,19,15,11,8,5,3,1,0,null,0.08,"-",0.32,"-",0.21,"-",0.253,8,"-"]
[2315,"A","L","H",8,9,0,0,0,31,0,30,2,"b","e","b","i",93,1,5,15,15,17,21,23,24,20,15,8,4,null,0.09,"-",0.34,"-",0.2,"-",0.26,8,"-"]
[2316,"L","L","H",8,9,0,0,0,0,0,0,3,"b","b","b","b",93,0,5,30,27,22,19,17,13,8,5,2,1,null,0.09,"-",0.29,"-",0.18,"-",0.253,8,"-"]
[2317,"L","L","H",9,9,0,0,0,0,0,0,9,"b","b","b","b",94,0,4,47,36,17,9,6,3,2,1,0,0,null,0.09,"-",0.28,"-",0.19,"-",0.253,8,"-"]
[2318,"E","L","H",9,9,0,0,0,38,0,20,3,"b","e","b","i",95,0,3,13,14,17,22,25,25,21,14,7,4,null,0.1,"-",0.41,"-",0.15,"-",0.263,8,"-"]
[2319,"Q","L","H",8,9,0,0,0,83,0,42,2,"b","e","b","e",93,1,5,10,10,12,16,19,22,23,20,13,9,null,0.11,"-",0.44,"-",0.17,"-",0.263,8,"-"]
[2320,"N","L","H",8,9,0,0,0,0,0,0,3,"b","b","b","b",91,1,8,31,27,21,18,16,12,8,4,2,1,null,0.13,"-",0.34,"-",0.19,"-",0.253,8,"-"]
[2321,"L","L","H",8,9,0,0,0,0,0,0,6,"b","b","b","b",93,1,5,36,31,21,16,12,8,5,3,2,1,null,0.17,"-",0.41,"-",0.19,"-",0.263,8,"-"]
[2322,"H","L","H",7,8,0,1,0,77,0,42,3,"b","e","b","e",87,2,12,6,7,9,12,16,21,25,25,18,13,null,0.14,"-",0.51,"D",0.28,"-",0.263,8,"-"]
[2323,"T","L","H",6,7,0,1,0,42,0,30,3,"b","e","b","i",80,2,20,11,12,14,18,21,24,23,19,13,9,null,0.16,"-",0.5,"D",0.17,"-",0.263,8,"-"]
[2324,"L","L","H",4,7,0,2,0,0,0,0,5,"b","b","b","b",72,4,26,35,30,23,18,14,9,5,3,2,1,null,0.22,"-",0.54,"D",0.14,"-",0.263,8,"-"]
[2325,"D","L","H",1,5,0,3,0,48,0,30,2,"b","e","b","i",59,5,40,11,12,14,17,21,23,23,20,16,12,null,0.24,"-",0.58,"D",0.14,"-",0.27,8,"-"]
[2326,"S","L","H",0,5,0,4,0,72,0,56,2,"b","e","b","e",53,5,46,9,9,11,13,16,18,21,23,22,20,null,0.23,"-",0.64,"D",0.18,"-",0.32,6,"-"]
[2327,"L","L","L",0,4,0,5,0,49,0,30,1,"b","e","b","i",45,7,53,11,12,15,19,21,22,21,18,16,14,null,0.22,"-",0.64,"D",0.25,"-",0.343,5,"-"]
[2328,"R","L","L",3,3,0,6,0,138,0,56,1,"b","e","b","e",33,8,64,9,10,12,15,18,20,22,23,22,22,null,0.2,"-",0.67,"D",0.27,"-",0.354,5,"-"]
[2329,"I","L","L",3,2,1,6,0,70,0,42,1,"b","e","b","e",27,12,66,12,13,15,18,20,21,22,21,19,17,null,0.19,"-",0.69,"D",0.42,"-",0.364,5,"-"]
[2330,"F","L","L",4,2,1,6,0,11,0,6,2,"b","b","b","b",23,16,64,19,22,25,25,21,17,12,9,8,8,null,0.2,"-",0.65,"D",0.42,"-",0.333,6,"-"]
[2331,"N","L","L",5,1,1,6,0,87,0,56,2,"b","e","b","e",19,12,71,7,7,9,12,15,19,22,24,24,23,null,0.22,"-",0.68,"D",0.47,"-",0.313,6,"-"]
[2332,"D","L","L",3,2,0,6,0,117,0,72,0,"b","e","b","e",30,7,67,10,11,12,15,17,20,20,20,21,21,null,0.22,"-",0.65,"D",0.52,"-",0.313,6,"-"]
[2333,"K","L","L",0,4,0,4,0,114,0,56,2,"b","e","b","e",45,8,51,7,7,9,11,14,17,20,22,22,21,null,0.17,"-",0.66,"D",0.32,"-",0.303,7,"-"]

{"sheet":"E52","index":29,"n_rows":43,"n_cols":40,"rows_kept":43,"merged":[[0,5,0,7],[0,17,0,19],[0,20,0,29]]}
["Counting residues","amino acid","observed secondary structure: H=helix, E=extended (sheet), L=loop","predicted secondary structure: H=helix, E=extended (sheet), L=loop","reliability index for PROFsec prediction (0=lo 9=high)","\"probability\" for assigning helix/strand/loop (10=high, 0=low)",null,null,"observed solvent accessibility (acc) in square Angstroem","predicted solvent accessibility (acc) in square Angstroem","observed relative solvent accessibility (acc) in 10 states: a value of n (=0-9) corresponds to a relative acc. of between n*n % and (n+1)*(n+1) % (e.g. for n=5: 16-25%).","predicted relative solvent accessibility (acc) in 10 states","reliability index for PROFacc prediction (0=low to 9=high)","observerd relative solvent accessibility (acc) in 2 states: b = 0-16%, e = 16-100%","predicted  relative solvent accessibility (acc) in 2 states","observerd relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%","predicted relative solvent accessibility (acc) in 3 states","actual neural network output from PROFsec for helix unit (H), strand unit (E), AND  'no-regular' unit (L)",null,null,"Ot4: actual neural network output from PROFsec for unit 0 coding for a relative solvent accessibility of 4*4 - 5*5 percent (16-25%). Note: OtN, with N=0-9 give the same information for the other output units!",{"$nulls":10},"raw score by NORSnet (prediction of unstructured loops)","two-state prediction by NORSnet; D=disordered","raw score by PROFbval (prediction of residue flexibility from sequence)","two-state prediction by PROFbval","raw score by Ucon (prediction of protein disorder using predicted internal contacts)","two-state prediction by Ucon","raw score by MD (prediction of protein disorder using orthogonal sources)","reliability of the prediction by MD; values range from 0-9. 9=strong prediction","two-state prediction by MD"]
["No","AA","OHEL","PHEL","RI_S","pH","pE","pL","OACC","PACC","OREL","PREL","RI_A","Obe","Pbe","Obie","Pbie","OtH","OtE","OtL","Ot0","Ot1","Ot2","Ot3","Ot4","Ot5","Ot6","Ot7","Ot8","Ot9",null,"NORSnet","NORS2st","PROFbval","bval2st","Ucon","Ucon2st","MD_raw","MD_rel","MD2st"]
[2518,"G","L","L",2,3,2,4,0,35,0,42,0,"b","e","b","e",33,22,53,11,11,12,15,18,20,22,22,21,20,null,0.29,"-",0.62,"D",0.85,"D",0.545,1,"D"]
[2519,"T","L","L",2,2,2,5,0,42,0,30,0,"b","e","b","i",31,23,54,12,12,14,16,19,21,21,21,19,18,null,0.27,"-",0.6,"D",0.69,"D",0.525,0,"D"]
[2520,"R","L","L",3,2,2,5,0,74,0,30,1,"b","e","b","i",27,23,58,11,13,15,19,21,22,22,20,18,16,null,0.29,"-",0.59,"D",0.42,"-",0.515,0,"-"]
[2521,"K","L","L",2,2,2,5,0,86,0,42,0,"b","e","b","e",30,22,57,10,11,12,15,18,20,23,23,22,20,null,0.3,"-",0.61,"D",0.44,"-",0.541,0,"D"]
[2522,"S","L","L",2,2,2,5,0,15,0,12,0,"b","b","b","i",30,22,57,18,18,18,20,19,19,18,16,15,13,null,0.3,"-",0.58,"D",0.59,"D",0.556,1,"D"]
[2523,"F","L","L",1,3,2,4,0,23,0,12,0,"b","b","b","i",34,28,49,20,20,20,21,19,18,15,13,11,10,null,0.37,"-",0.54,"D",0.67,"D",0.551,1,"D"]
[2524,"D","L","L",1,2,2,4,0,48,0,30,1,"b","e","b","i",33,31,48,12,13,15,18,20,22,21,20,17,15,null,0.41,"-",0.56,"D",0.67,"D",0.561,1,"D"]
[2525,"H","L","L",0,2,3,4,0,55,0,30,1,"b","e","b","i",31,36,45,14,15,17,20,22,23,21,18,15,13,null,0.42,"-",0.52,"D",0.78,"D",0.582,2,"D"]
[2526,"L","L","L",0,2,3,4,0,19,0,12,0,"b","b","b","i",28,39,46,19,19,19,20,20,19,17,15,12,11,null,0.4,"-",0.49,"D",0.63,"D",0.582,2,"D"]
[2527,"I","L","L",0,2,3,4,0,20,0,12,0,"b","b","b","i",25,40,46,21,21,21,22,20,18,15,13,10,9,null,0.42,"-",0.49,"D",0.65,"D",0.602,3,"D"]
[2528,"S","L","L",2,2,2,5,0,54,0,42,0,"b","e","b","e",25,29,54,13,13,14,16,18,20,21,21,21,20,null,0.43,"-",0.5,"D",0.89,"D",0.636,4,"D"]
[2529,"D","L","L",4,2,2,5,0,48,0,30,0,"b","e","b","i",22,21,62,9,10,13,16,19,21,21,21,21,20,null,0.41,"-",0.56,"D",0.87,"D",0.626,4,"D"]
[2530,"T","L","L",4,1,1,6,0,28,0,20,0,"b","e","b","i",18,18,67,13,13,15,18,20,20,20,19,19,18,null,0.45,"-",0.6,"D",0.91,"D",0.636,4,"D"]
[2531,"K","L","L",6,1,1,7,0,147,0,72,2,"b","e","b","e",13,14,75,5,6,8,11,14,17,20,23,26,26,null,0.43,"-",0.65,"D",0.97,"D",0.657,5,"D"]
[2532,"A","L","L",6,1,0,7,0,31,0,30,1,"b","e","b","i",14,10,78,14,14,16,19,20,21,20,18,17,15,null,0.47,"-",0.64,"D",0.97,"D",0.646,5,"D"]
[2533,"P","L","L",4,2,1,6,0,40,0,30,0,"b","e","b","i",22,11,71,12,13,14,18,19,21,20,19,19,18,null,0.49,"-",0.65,"D",0.98,"D",0.646,5,"D"]
[2534,"K","L","L",2,2,1,5,0,147,0,72,2,"b","e","b","e",32,15,60,5,6,7,10,14,18,22,25,26,26,null,0.55,"D",0.62,"D",0.97,"D",0.646,5,"D"]
[2535,"R","L","L",2,2,1,5,0,74,0,30,1,"b","e","b","i",31,16,59,12,13,15,18,20,21,21,19,17,16,null,0.49,"-",0.61,"D",0.97,"D",0.636,4,"D"]
[2536,"Q","L","L",3,2,1,5,0,39,0,20,0,"b","e","b","i",26,20,59,14,15,17,19,21,21,20,19,17,16,null,0.49,"-",0.61,"D",0.86,"D",0.636,4,"D"]
[2537,"E","L","L",3,2,2,5,0,108,0,56,2,"b","e","b","e",25,23,59,7,8,10,13,16,20,23,24,23,21,null,0.55,"D",0.62,"D",0.86,"D",0.636,4,"D"]
[2538,"M","L","L",3,2,2,5,0,22,0,12,1,"b","b","b","i",23,23,58,17,19,21,23,22,19,16,13,12,11,null,0.57,"D",0.6,"D",0.82,"D",0.626,4,"D"]
[2539,"E","L","L",4,2,1,6,0,58,0,30,0,"b","e","b","i",24,18,64,12,12,14,17,19,21,21,21,20,19,null,0.55,"D",0.61,"D",0.73,"D",0.612,3,"D"]
[2540,"S","L","L",4,2,1,6,0,93,0,72,0,"b","e","b","e",23,16,65,12,13,14,16,18,19,20,20,21,21,null,0.53,"D",0.56,"D",0.74,"D",0.626,4,"D"]
[2541,"G","L","L",4,1,1,6,0,35,0,42,0,"b","e","b","e",20,19,66,13,13,14,17,19,20,21,20,19,18,null,0.53,"D",0.56,"D",0.82,"D",0.626,4,"D"]
[2542,"I","L","L",3,1,2,6,0,20,0,12,1,"b","b","b","i",12,27,66,19,20,22,23,21,18,15,12,11,11,null,0.53,"D",0.56,"D",0.65,"D",0.606,3,"D"]
[2543,"T","L","L",4,0,2,6,0,42,0,30,0,"b","e","b","i",10,25,69,14,14,15,17,19,21,21,21,19,18,null,0.55,"D",0.56,"D",0.78,"D",0.616,4,"D"]
[2544,"T","L","L",5,0,1,7,0,17,0,12,1,"b","b","b","i",9,18,75,18,19,20,22,21,19,16,14,12,11,null,0.55,"D",0.56,"D",0.74,"D",0.626,4,"D"]
[2545,"P","L","L",5,1,1,7,0,40,0,30,1,"b","e","b","i",14,16,72,14,14,16,18,20,21,20,19,17,16,null,0.59,"D",0.61,"D",0.62,"D",0.626,4,"D"]
[2546,"P","L","L",3,2,1,6,0,27,0,20,0,"b","e","b","i",24,17,63,14,15,16,19,21,21,20,19,18,16,null,0.61,"D",0.61,"D",0.64,"D",0.636,4,"D"]
[2547,"K","L","L",2,3,1,5,0,86,0,42,0,"b","e","b","e",33,18,57,11,12,13,16,18,20,21,21,20,19,null,0.62,"D",0.62,"D",0.83,"D",0.636,4,"D"]
[2548,"M","L","L",2,3,1,5,0,22,0,12,1,"b","b","b","i",34,17,57,18,19,21,22,21,19,15,13,11,10,null,0.54,"D",0.62,"D",0.83,"D",0.643,5,"D"]
[2549,"R","L","L",3,2,1,5,0,74,0,30,0,"b","e","b","i",29,18,62,11,12,14,17,20,22,22,21,19,17,null,0.57,"D",0.65,"D",0.88,"D",0.626,4,"D"]
[2550,"R","L","L",3,2,1,5,0,74,0,30,0,"b","e","b","i",24,20,63,11,12,14,17,19,21,21,21,20,18,null,0.61,"D",0.66,"D",0.73,"D",0.636,4,"D"]
[2551,"V","L","L",4,1,1,6,0,42,0,30,1,"b","e","b","i",21,18,67,13,14,16,19,20,21,19,18,17,16,null,0.61,"D",0.65,"D",0.76,"D",0.633,4,"D"]
[2552,"A","L","L",5,1,1,6,0,31,0,30,0,"b","e","b","i",19,15,70,13,13,15,18,20,21,20,20,19,18,null,0.61,"D",0.64,"D",0.5,"-",0.622,4,"D"]
[2553,"E","L","L",4,2,1,6,0,81,0,42,0,"b","e","b","e",22,12,71,9,10,12,16,18,21,23,23,23,21,null,0.59,"D",0.68,"D",0.69,"D",0.622,4,"D"]
[2554,"T","L","L",4,2,0,6,0,102,0,72,0,"b","e","b","e",24,10,72,11,11,13,16,18,19,20,20,22,22,null,0.62,"D",0.64,"D",0.65,"D",0.612,3,"D"]
[2555,"D","L","L",4,2,1,6,0,117,0,72,1,"b","e","b","e",24,12,67,9,9,11,14,16,18,20,22,24,24,null,0.65,"D",0.65,"D",0.66,"D",0.596,3,"D"]
[2556,"Y","L","L",4,2,1,6,0,66,0,30,1,"b","e","b","i",23,13,68,12,13,15,19,20,21,20,19,17,16,null,0.61,"D",0.65,"D",0.76,"D",0.586,2,"D"]
[2557,"E","L","L",5,1,1,6,0,81,0,42,0,"b","e","b","e",17,15,71,12,12,14,17,18,20,21,21,20,19,null,0.62,"D",0.67,"D",0.64,"D",0.576,2,"D"]
[2558,"M","L","L",4,2,1,6,0,56,0,30,1,"b","e","b","i",21,18,65,15,15,17,19,20,21,19,18,16,15,null,0.64,"D",0.64,"D",0.59,"D",0.576,2,"D"]