{"text_format":"3","workbook":"xlsx","n_sheets":1,"sheets":["Supplementary table3"],"read":"whole","date_system":"1900"}

{"sheet":"Supplementary table3","index":0,"n_rows":23,"n_cols":11,"rows_kept":23}
["Category","Term","Count","%","PValue","Genes","List Total","Pop Hits","Pop Total","Fold Enrichment","Benjamini"]
["SP_PIR_KEYWORDS","egf-like domain",46,3.56037151702786,{"v":1.16528415600691E-11,"d":"1.17E-11"},"NRG3, CRELD2, LDLR, ADAM21P1, ASTN1, MMRN1, ITGBL1, HMCN2, HMCN1, CD93, FAT1, IMPG2, ACAN, CNTNAP2, TPO, FBN3, TNN, FBN2, NRG2, MUC12, CUBN, NRXN2, NRXN3, ATRN, NOTCH2NL, CELSR3, CELSR2, SSPO, MUC4, SLIT3, NOTCH2, MUC3A, CLEC18A, THBD, LRP1, SNED1, FBLN2, OTOG, RELN, ADAM22, ADAM19, LRP2, MEGF6, ADAM12, SELE, LRP5",1227,230,19235,3.13528932355338,{"v":2.21014584411705e-09,"d":"2.21E-09"}]
["SP_PIR_KEYWORDS","tyrosine-specific phosphatase",11,0.851393188854489,{"v":1.37581064329726E-5,"d":"1.38E-05"},"PTPRC, PTPRD, PTPN3, PTPRZ1, PTPRH, PTPRN2, PTPN4, PTPN21, PTPRO, CDC25A, PTPN12",1227,31,19235,5.56261009017535,{"v":9.78073425648484E-4,"d":"9.78E-04"}]
["SP_PIR_KEYWORDS","actin-binding",34,2.63157894736842,{"v":4.48663919421868e-05,"d":"4.49E-05"},"HIP1R, MYO7B, SSFA2, MYBPC3, SSH2, WASF2, PXK, VILL, VCL, ESPN, MACF1, DMD, WIPF3, INF2, DBNL, PHACTR2, SPTBN5, MYH1, SPTBN4, MYH7, ACTN2, EVL, MYH6, VASP, MYO18B, SYNE2, TNS1, MIB2, FHOD3, MYH13, WASL, MYH14, MYH7B, PARVA",1227,247,19235,2.15789143726346,0.00283259724095563]
["SP_PIR_KEYWORDS","sh3 domain",30,2.3219814241486,{"v":6.99378398068517e-05,"d":"6.99E-05"},"MYO7B, BCAR1, NCF1C, CACNB2, ASAP1, ITSN2, CACNB4, ARHGAP4, MIA2, MACF1, PACSIN3, PACSIN2, PSTPIP1, DLG5, RASA1, PIK3R2, CASKIN1, SH3PXD2B, DBNL, SASH1, NOXO1, EFS, SH3BP4, ARHGAP33, FCHSD2, SH3RF3, CRK, TJP2, SASH3, SRGAP2",1227,210,19235,2.2394923739667,0.00361128379970265]
["SP_PIR_KEYWORDS","atp-binding",119,9.21052631578947,{"v":1.15353956537986E-4,"d":"1.15E-04"},"POTEKP, STK35, TTK, ITPKA, KIF13A, NLRC5, ATP2B2, DDX17, OPLAH, DHX35, MAP2K7, MAP2K5, EGFR, MAGI3, CARS, BCR, MYH1, MAGI1, PIK3CB, MYH7, MYH6, HNRNPU, MYO18B, NME3, NAV2, SMARCA5, BMP2K, FLAD1, MYO18A, MYH7B, NEK6, NEK7, DNAH11, FGFR2, DNAH17, TDRD9, CHEK1, CHEK2, RIOK1, ABCA4, ABCA3, TTBK1, DDX60L, MKI67, MAP2K2, MAP2K3, ATP11A, BRIP1, SMG1, ABCB1, ATP11C, DDX4, RPS6KL1, ATP13A4, EPHA6, EPHA8, ATP2A1, MYH13, HSPD1, MTOR, MYH14, FPGT, GUK1, UBE2E1, PC, KIF25, CDK17, HELQ, MYO7B, ATP10A, HLCS, MOV10L1, HELZ, PIP5K1A, DDR2, MCM8, ATAD3B, CHUK, ABCE1, SGK1, LIMK1, MINK1, CFTR, TOP1MT, CBWD3, PANK3, CBWD1, CDK11A, RRM1, ERN2, TNNI3K, CDK11B, SMARCAD1, DNAH9, MKNK2, BRSK2, AKAP9, BRSK1, DNAH7, BMS1, STK32C, MAP3K3, SPEG, DGKG, ABCD2, HSPA7, CAMK2B, PRKAA1, CAMK2A, AATK, ABCA12, ACSL5, FLT1, FLT4, NLK, UBE2Q2, RPS6KA5, ROCK1P1, ABCC3, SLFN13, ABCC5",1227,1326,19235,1.40686059390215,0.00545508231137226]
["SP_PIR_KEYWORDS","extracellular matrix",32,2.47678018575851,{"v":1.52658707545653E-4,"d":"1.53E-04"},"ADAMTSL1, ADAMTS14, CALR, LAMB4, COL9A3, HMCN1, COL27A1, COL6A3, ACAN, FBN3, FBN2, COL11A1, SPP1, COL18A1, WNT10A, HAPLN3, ZP3, COL13A1, LGALS1, MEPE, COL5A3, COL5A1, COL4A6, COL4A5, LAMA2, ADAMTS6, LAMA5, FBLN2, COL1A2, RELN, COL1A1, CHL1",1227,241,19235,2.08151988285701,0.00665998758470809]
["SP_PIR_KEYWORDS","metal-binding",236,18.266253869969,{"v":0.000166998107370648,"d":"1.67E-04"},"ALAD, PDLIM5, RNF213, RNF212, ZNF251, ATP2B2, PLOD2, PRIM2, BIRC8, MAP2K7, FTL, MAP2K5, ZNF43, UBR4, ZNF503, MECOM, ADAMTS6, UHRF1, NME3, NEK6, NEK7, FUS, ZNF519, TRIM64C, ZNF611, CYP2B6, ZNF76, ASAP1, CHEK2, CALR, ADAP1, TCF20, DAGLA, RPS29, DMD, CASZ1, COL18A1, DNMT3A, ZNF620, KLF10, KLF11, KLF17, ATP11A, ATP11C, DAGLB, ZNF525, ATP13A4, PXDNL, ZBTB42, CBLC, NR1I2, ATP2A1, ZFHX3, RERE, DPP3, ATP10A, ZMAT2, ZNF530, ARSI, HELZ, ZEB2, ZNF347, ZNF346, CANX, GLI3, STAC3, ASH2L, ZNF491, ZNF735, NOS2, AGAP2, NR2F1, KCNMA1, TP53, ZNF141, HERC2, ZSWIM2, MMP14, VPS8, ZDHHC14, ZDHHC17, ZDHHC11, PPEF2, ASH1L, ADAM19, ADAM12, KSR1, NSD1, REV3L, CDRT1, THAP7, LIMS1, ZNF469, FHL3, MKNK2, POLA1, CBLL1, ALPP, LOC440434, CYP2A13, CYP27B1, GNPTAB, BCL11B, TYW1, DGKG, DTNB, GATAD2B, PRKAA1, PPP3CA, RFPL3, RASA3, MLLT6, ZNF267, NLK, ZNF770, PDZRN3, SOD2, RPS6KA5, LRP1, PHF14, JMJD6, ROCK1P1, COG8, SH3RF3, ZBTB4, PHF21A, NLN, DPYD, ADH1C, ZXDB, RPS27L, APOBEC3H, ENPEP, ZIC2, APOBEC3D, TRIM46, TRIM48, AGAP9, TRIM43, TRIM44, ZNF578, RBM10, SAR1B, RNF145, CARS, ZNF813, NPEPPS, SUZ12, KDM2B, MIB2, RELN, ZNF436, ZNF845, TSHZ2, ZC3H4, ADAM21P1, ZNF846, PRUNE2, PEG10, FGD6, ADSSL1, LPO, EHMT1, LPP, ZMYM5, NR4A2, SMG1, NR4A3, CACNA2D2, FOXP1, MAN2C1, TET3, CADPS2, POLD1, ANTXR2, HIVEP1, ADAM22, FPGT, PC, ZNF85, RAI1, KDM6A, NPEPL1, CTCF, ZKSCAN3, ZZEF1, MAZ, ZNF727, TPO, RANBP2, MAN2B1, IMPDH1, PHC2, NFX1, ZCCHC4, ZNF280C, NRXN2, LIMK1, NRXN3, COQ7, MYT1L, ZNF718, ZMIZ2, ZMIZ1, UBC, CYP2A6, ERN2, TNNI3K, ZFPM2, CHFR, CPSF3, ZNF99, ADAMTS14, ABLIM3, PRSS1, BRSK2, ADH5, BRSK1, PPM1B, STK32C, NPTX1, PRDM15, MAP3K3, TGM3, XAF1, ING1, DUS3L, ADARB1, ADARB2, CBL, CREB5, ZNF705G, CADPS, RNF112, ADI1, RNF44, SULF2, SUMF2",1227,2972,19235,1.24483223478902,0.00676486161854217]
["SP_PIR_KEYWORDS","repressor",48,3.71517027863777,{"v":0.000279299926226867,"d":"2.79E-04"},"ZNF85, SBNO2, ETV7, BCLAF1, CBX4, ZEB2, CTCF, TCERG1, BCL11B, ANP32A, GATAD2B, LRRFIP1, NFX1, NFATC1, NKRF, ATF7IP, DNMT3A, ERF, SATB2, RCOR2, JARID2, KLF10, KLF11, MECP2, MED12, KLF17, ZNF141, TLE4, ZNF503, BANP, MED13, MED13L, FOXP1, FOXN3, SUZ12, CHMP1A, KDM2B, MSX1, HDAC2, PHF21A, CELF2, ZFPM2, PBX1, CUX1, NSD1, NCOR1, HDAC7, RERE",1227,435,19235,1.72981479920186,0.00988481186716705]
["SP_PIR_KEYWORDS","isopeptide bond",38,2.94117647058823,{"v":3.12931532751323E-4,"d":"3.13E-04"},"HIST1H2AC, TNRC18, GRIK2, RAD23A, CBX4, ELK1, SYNCRIP, CHEK1, ZEB2, GON4L, CTCF, PIP5K1A, HIST2H2AB, CUL2, HSF1, RANBP2, HNRNPC, ACIN1, KPNB1, POTEE, EGFR, SATB2, TP53, MYH7, MYH6, CCDC138, HIST2H3D, PSMA1, UHRF1, MSX1, EVPL, TRAF3IP3, ASH1L, UBC, TFAP2A, CUL4B, UBXN7, CPSF3",1227,319,19235,1.86741370368383,0.00984488029025465]
["SP_PIR_KEYWORDS","Endocytosis",17,1.31578947368421,{"v":0.000352855434299151,"d":"3.53E-04"},"DBNL, SYNRG, STON1, CUBN, CALY, LDLR, HIP1R, GTF2A1L, EPS15L1, ITSN2, CLEC10A, SH3BP4, LRP1, THBD, PACSIN3, PACSIN2, LRP2, LRP5",1227,96,19235,2.77603742189622,0.00999027100491278]
["SP_PIR_KEYWORDS","transcription regulation",166,12.8482972136222,{"v":4.93965034460364E-4,"d":"4.94E-04"},"STAT5A, STAT5B, CNOT3, HOXD12, CBX4, CNOT2, ZXDB, ZNF251, CTNNB1, CDKN2A, CGGBP1, SND1, ZNF578, SSX9, ZNF43, SATB2, RCOR2, MED12, MECP2, ZNF813, ZNF503, ARID1A, MED13, GRHL1, MECOM, FOXN3, SUZ12, UHRF1, KDM2B, MSX1, TFAP2A, TFAP2D, ZNF436, ZNF845, ZNF519, CRTC2, MEAF6, TSHZ2, ZNF611, HOXA13, ZNF76, SETD1A, ELK1, KEAP1, TRRAP, ZNF846, TCF21, TCF20, AHRR, TCERG1, CASZ1, TFDP3, RUNX1, RUNX2, TCF3, SSX1, TAF2, NKRF, ZNF620, KLF10, KLF11, NR4A2, KLF17, EN1, TEAD2, GTF2A1L, NR4A3, MED13L, ZNF525, FOXP1, ATF6, NOTCH2, NR1I2, HDAC2, SMARCC2, HIVEP1, NCOR1, ZFHX3, HDAC7, RERE, ZNF85, TAF1C, ZNF530, ZEB2, CTCF, ZNF347, ZKSCAN3, GLI3, PAX1, FUBP1, ARHGAP22, MCM8, MAZ, HSF1, ASH2L, ZNF727, ZNF491, ANP32A, ZNF735, LRRFIP1, NFX1, NR2F1, ATF7IP, SNAPC5, SSBP3, CCNK, ZNF280C, ARID5B, SNAPC3, SOX12, TP53, ZNF141, TLE4, BANP, MYT1L, ZNF718, CHMP1A, BRWD1, ZMIZ2, ZMIZ1, ASH1L, KHSRP, BRDT, FOXC2, ERN2, ZFPM2, WASL, CUX1, NSD1, ZNF99, FOXD4L5, THAP7, SBNO2, BCLAF1, ETV7, ZNF469, STON1, NPAS1, PRDM15, NPAS2, NPAS3, RB1CC1, BCL11B, POU2F2, POU2F1, GATAD2B, BCL3, PER3, FOXD4, NFATC1, ZNF267, SIM2, ERF, JARID2, NLK, ZNF770, AFF3, CREB5, WWTR1, POU5F1B, ZNF705G, JMJD6, ATXN7, FOXE1, ZBTB4, PHF21A, PBX1",1227,2026,19235,1.28444725496017,0.0132981941677909]
["SP_PIR_KEYWORDS","triple helix",9,0.696594427244582,{"v":0.000560915288958202,"d":"5.61E-04"},"COL13A1, DMD, COL6A3, COL1A2, COL1A1, COL11A1, COL5A1, COL4A6, COL4A5",1227,31,19235,4.5512264374162,0.0144065966670889]
["SP_PIR_KEYWORDS","nucleus",321,24.84520123839,{"v":0.00060363875882896,"d":"6.04E-04"},"STAT5A, PPP2R5C, STAT5B, HOXD12, INTS1, SYNCRIP, INTS2, WTAP, ZNF251, CTNNB1, DDX17, INTS5, INTS4, RPP30, MAP2K7, ZNF43, MAGI3, RCOR2, PTBP1, MED12, MECP2, UBR4, ZNF503, NAV3, MED13, MECOM, ERGIC2, MYO18B, UHRF1, MSX1, MAD2L1, NAV2, CMIP, PDE4DIP, NEK6, FUS, TP53TG3, CRTC2, ZNF519, ZNF611, HOXA13, RAD23A, ZNF76, CHEK1, CHEK2, XAB2, ADAP1, TCF21, TCF20, AHRR, FRG2, FRG1, CASZ1, AHNAK2, PABPC1, TCF3, NKRF, DNMT3A, NOC4L, MKI67, ZNF620, KLF10, KLF11, KLF17, EN1, DUSP21, ZNF525, ZBTB42, NOTCH2, CBLC, NR1I2, SYNE2, DCP1B, ETS2, NCOR1, ZFHX3, RERE, TAF1C, UTP18, GAR1, ZNF530, TCOF1, ZMAT2, HELZ, ZEB2, ZNF347, ZNF346, GLI3, HIST2H2AB, DIP2A, ASH2L, HSF1, ANP32A, ZNF491, SPANXD, QKI, ZNF735, SPANXC, BRD4, TWISTNB, AGAP2, FANCA, NR2F1, ATF7IP, SNAPC5, RBM42, HIST1H1B, SNAPC3, TP53, ZNF141, TLE4, CHMP1A, BRWD1, DACT1, CDK11A, ASH1L, BRDT, NOL11, FOXC2, CDK11B, NSD1, ARL4C, FOXD4L5, REV3L, HIST1H2AC, ZNF469, ETV7, POLA1, BMS1, LOC440434, SPEG, BCL11B, RB1CC1, GATAD2B, BCL3, PPP3CA, PER3, SNRNP70, TBC1D1, MLLT6, FOXD4, SIM2, NMD3, ZNF267, RRP12, PDS5A, JARID2, NUCKS1, NLK, ZNF770, AFF3, WWTR1, RPS6KA5, LRP1, JMJD6, ZBTB4, FOXE1, PHF21A, PBX1, USP48, TJP2, RALY, STK35, CBX4, CNOT3, ZXDB, UBQLN4, CNOT2, ZIC2, CDKN2A, CGGBP1, SND1, ZNF578, SRRM1, PMS2, ACIN1, ITCH, RBM10, PABPN1, SATB2, ZNF813, ARID1A, NPEPPS, GRHL1, TACC1, FOXN3, HNRNPU, SUZ12, PNPLA7, PSMA1, KDM2B, BMP2K, SMARCA5, TFAP2A, CELF2, TFAP2D, ZNF436, ZNF845, MEAF6, TSHZ2, SETD1A, ELK1, KEAP1, TRRAP, HEXDC, DAZAP1, ZNF846, PEG10, TCERG1, NIPBL, POLE3, TFDP3, HNRNPC, RUNX1, RUNX2, TAF2, EHMT1, C17ORF49, LPP, ZMYM5, RFX7, NR4A2, SMG1, BRIP1, SYCE1, GTF2A1L, HEATR1, TEAD2, NR4A3, MED13L, DPPA3, RBMX, AIM2, FOXP1, HIST2H3D, ATF6, HDAC2, POLD1, SMARCC2, HIVEP1, HNRNPH1, FPGT, HDAC7, ZNF85, RAI1, KDM6A, CTCF, TIMM50, DEK, EPS15L1, ZKSCAN3, PTMA, PAX1, FUBP1, ARHGAP22, MCM8, MAZ, PLRG1, ZNF727, HNRNPCL1, LRRFIP1, RANBP2, KPNB1, CHUK, AHNAK, PHC2, NFX1, NOL6, SSBP4, SGK1, SSBP3, ZNF280C, ARID5B, SOX12, TP53TG3B, BANP, MYT1L, ZNF718, XPC, ZMIZ2, EIF5AL1, ZMIZ1, TPPP, CPSF7, KHSRP, UBC, TNNI3K, ZFPM2, WASL, CPSF3, CHFR, CUX1, ZNF99, SMARCAD1, BCLAF1, STON1, IRX5, GON4L, HCFC2, WBP11, BRSK1, NPAS1, NPAS2, PRDM15, NPAS3, POM121, POU2F2, MSI1, POU2F1, CALML6, XAF1, MYOF, ING1, GEMIN5, NFATC1, ERF, DGCR6L, ADARB2, NFRKB, SCOC, CREB5, POU5F1B, ZNF705G, ADI1, SH3BP4, ATXN7",1227,4283,19235,1.1749099613129,0.0148269884830132]
["SP_PIR_KEYWORDS","Transcription",168,13.0030959752321,{"v":0.000729001386490658,"d":"7.29E-04"},"STAT5A, STAT5B, CNOT3, HOXD12, CBX4, CNOT2, ZXDB, ZNF251, CTNNB1, CDKN2A, CGGBP1, SND1, PRIM2, ZNF578, SSX9, ZNF43, SATB2, RCOR2, MED12, MECP2, ZNF813, ZNF503, ARID1A, MED13, GRHL1, MECOM, FOXN3, SUZ12, UHRF1, KDM2B, MSX1, TFAP2A, TFAP2D, ZNF436, ZNF845, ZNF519, CRTC2, MEAF6, TSHZ2, ZNF611, HOXA13, ZNF76, SETD1A, ELK1, KEAP1, TRRAP, XAB2, ZNF846, TCF21, TCF20, AHRR, TCERG1, CASZ1, TFDP3, RUNX1, RUNX2, TCF3, SSX1, TAF2, NKRF, ZNF620, KLF10, KLF11, NR4A2, KLF17, TEAD2, GTF2A1L, NR4A3, MED13L, ZNF525, FOXP1, ATF6, NOTCH2, NR1I2, HDAC2, SMARCC2, HIVEP1, NCOR1, ZFHX3, HDAC7, RERE, ZNF85, TAF1C, ZNF530, ZEB2, CTCF, ZNF347, ZKSCAN3, GLI3, PAX1, FUBP1, ARHGAP22, MCM8, MAZ, HSF1, ASH2L, ZNF727, ZNF491, ANP32A, ZNF735, LRRFIP1, TWISTNB, NFX1, NR2F1, ATF7IP, SNAPC5, SSBP3, CCNK, ZNF280C, ARID5B, SNAPC3, SOX12, TP53, ZNF141, TLE4, BANP, MYT1L, ZNF718, CHMP1A, BRWD1, ZMIZ2, ZMIZ1, ASH1L, KHSRP, BRDT, FOXC2, ERN2, ZFPM2, WASL, CUX1, NSD1, ZNF99, FOXD4L5, THAP7, SBNO2, BCLAF1, ETV7, ZNF469, STON1, NPAS1, PRDM15, NPAS2, NPAS3, RB1CC1, BCL11B, POU2F2, POU2F1, GATAD2B, BCL3, PER3, FOXD4, NFATC1, ZNF267, SIM2, ERF, JARID2, NLK, ZNF770, AFF3, CREB5, WWTR1, POU5F1B, ZNF705G, JMJD6, ATXN7, FOXE1, ZBTB4, PHF21A, PBX1",1227,2071,19235,1.27167698299606,0.0164611324587111]
["SP_PIR_KEYWORDS","trimer",8,0.619195046439628,{"v":0.00094425983203033,"d":"9.44E-04"},"COL13A1, COL6A3, COL1A2, COL1A1, COL11A1, COL5A1, COL4A6, COL4A5",1227,26,19235,4.82352203623597,0.0197119311118548]
["SP_PIR_KEYWORDS","phosphoric monoester hydrolase",13,1.00619195046439,0.00127496570787361,"PTPRC, PTPRD, PTPN3, PTPRZ1, PTPRH, PTPRN2, PTPN4, PTPN21, PPP3CA, ALPP, PTPRO, CDC25A, PTPN12",1227,69,19235,2.95353342073869,0.0255924709886175]
["SP_PIR_KEYWORDS","calcium channel",12,0.928792569659442,1.47902127525426E-3,"RYR1, CACNA1G, CACNA1H, RYR2, CACNB2, CACNA1E, CACNB4, CACNA1C, CACNA2D2, ITPR1, CACNA1A, ITPR2",1227,61,19235,3.08389113792135,0.0286232644756189]
["SP_PIR_KEYWORDS","hydroxylation",13,1.00619195046439,0.00164700592548037,"COL18A1, COL9A3, THBD, COL6A3, COL1A2, CELSR3, CELSR2, COL1A1, COL5A3, COL11A1, COL5A1, COL4A6, COL4A5",1227,71,19235,2.87033529621084,0.0307803011859828]
["SP_PIR_KEYWORDS","collagen",15,1.1609907120743,0.0027152430305573,"COL18A1, COL23A1, COL13A1, COL5A3, COL5A1, COL4A6, COL4A5, COL9A3, PLOD2, COL27A1, COL6A3, COL1A2, COL1A1, EDA, COL11A1",1227,95,19235,2.47522841333161,0.0486808052126886]
[]
[]
["Supplementary Table3 Keywords Enriched analysis of frequently mutated genes."]