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["Table 1. Characteristics of the included studies."]
["Author-year","status","Study design","Study population (N)","Drop out/loss data","Tumor location","Region ","Risk of bias assessment"]
["Patil-2020[17]","ECOG PS of 0–1","Open-label, parallel, randomized, phase 3 trial","422, mean age 48","4 withdrew","Oral cavity and others, except salivary gland, thyroid, nasopharynx","Mumbai, India","High quality"]
["Swiecicki-2016[18]","ECOG PS of 0–1","A phase 2, three-arm, randomized, open label trial","35, median age 57","Not report","Head and neck cancer (oropharynx was the most common primary site)","Michigan","Moderate quality"]
["Patil-2015[19]","KPS 70 or more","An open label, parallel, randomized phase II trial","110, median age 45","4 Withdrew","Head and neck squamous cell cancers","Mumbai, India","Moderate quality "]
["Lin-2015[20]","American Joint Committee on Cancer Staging","Cohort study","80, median age 51.2","Not report","Oral cavity","Taiwan","high quality"]
["Patil-2019[21]","ECOG PS of 0-2","Single-arm study","76, median age 41","46 deaths","Oral cavity","India","High quality"]
["Patil-2017[24]","ECOG PS of 0–2","Match pair analysis ","120, median age 52 ","Not report","Oral cavity, oropharynx, hypopharynx, larynx","Mumbai, India","High quality"]
["Lee-2017[22]","ECOG PS of 0-2","A prospective phase II single-arm open-label study","56, median age 51 ","Not report","Nasopharyngeal carcinoma","Hong Kong","Moderate quality"]
["Patil-2016[23]","ECOG PS of 0-2","Single-arm prospective study","15, median age 65 ","3 deaths","Oral cavity, oropharynx, hypopharynx","Kerala, India","High quality"]
["Patil-2017[25]","ECOG PS of 0–2","Retrospective analysis ","340, median age 48","Not report","oral cavity, oropharynx, larynx, hypopharynx, maxilla","Mumbai, India","Moderate quality"]
["Rohit-2017[26]","ECOG PS of 0-3 ","Retrospective study","32, Median age 65.21","Not report","Head and neck cancer","Florida","Moderate quality"]
["Pandey-2016[27]","Without report","Retrospective study","130, median age 54 ","Not report","Oral cavity","Mumbai, India","Moderate quality "]
["Pai-2013[28]","Without report","Retrospective analysis",64,"Not report","Oral cavity","India","Moderate quality"]
["Patil-2012[29]","ECOG PS of 1-2","Retrospective analysis ","18, median age 50.5 ","Not report","Oral cavity","Mumbai, India","Moderate quality"]
["ECOG PS: Eastern Cooperative Oncology Group performance status score; KPS: Karnofsky Performance Status."]