{"text_format":"3","workbook":"xlsx","n_sheets":16,"sheets":["Table 1","Table 2","Table 3a,b","Table 4a-i","Table 5a,b","Table 6a,b","Table 6c,d","Table 7","Table 8","Table 9a,b","Table 10a-c","Table 11a,b","Table 12a,b","Table 13a-h","Table 14a-c","Table 15"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900"}

{"sheet":"Table 1","index":0,"n_rows":74,"n_cols":6,"rows_kept":74,"merged":[[2,0,3,0],[2,1,2,2],[2,3,2,4],[2,5,3,5]]}
["Supplementary Table 1. Overview of studied human subjects within this study."]
[]
[null,"Training set",null,"Validation set",null,"Total"]
[null,"M","F","M","F"]
["Control",60,75,32,25,{"$f":"SUM(B5:E5)","v":192}]
["BMI","26.9 ± 3.5","25.4 ± 4.0","27.6 ± 3.7","25.7 ± 5.5"]
["Age","53.7 ± 11.3","51.2 ± 11.6","49.7 ± 10.2","51.8 ± 12.1"]
["breast",7,70,2,24,{"$f":"SUM(B8:E8)","v":103}]
["BMI","26.1 ± 6.7","26.74 ± 5.32","26.1 ± 1.6","29.51 ± 6.45"]
["Age","66.1 ± 5.0","58.3 ± 11.8","64.5 ± 5.5","61.7 ± 11.6"]
["Stages"]
["T1",null,43,null,18,{"$f":"SUM(B12:E12)","v":61}]
["T2",null,3,null,3,6]
["T3","-","-","-","-","-"]
["T4",1,{"$nulls":3},1]
["Tis",null,8,null,null,8]
["Tx","-","-","-","-","-"]
["n.a.",6,16,2,3,27]
["N0",null,46,null,14,60]
["N1",null,6,null,6,12]
["N2",null,2,null,1,3]
["Nx",1,1,null,null,2]
["n.a.",6,15,2,3,26]
["M0","-","-","-","-","-"]
["M1",1,{"$nulls":3},1]
["Mx",6,45,null,20,71]
["n.a.",null,25,2,4,31]
["kidney",57,25,30,7,{"$f":"SUM(B28:E28)","v":119}]
["BMI","28.2 ± 4.5","28.1 ± 6.0","27.4 ± 3.5","25.7 ± 5.7"]
["Age","63.3 ± 11.8","65.4 ± 11.6","61.5 ± 9.8","64.7 ± 8.1"]
["Stages"]
["T1",23,11,17,5,{"$f":"SUM(B32:E32)","v":56}]
["T2",7,5,3,1,16]
["T3",26,8,9,1,44]
["T4",null,null,1,null,1]
["Tx",1,{"$nulls":3},1]
["n.a.",null,1,null,null,1]
["N0",44,23,17,6,90]
["N1",5,1,2,1,9]
["N2",2,{"$nulls":3},2]
["Nx",6,null,11,null,17]
["n.a.",null,1,null,null,1]
["M0",46,22,17,6,91]
["M1",8,2,2,1,13]
["Mx",3,null,11,null,14]
["n.a.",null,1,null,null,1]
["prostate",50,null,17,null,{"$f":"SUM(B47:E47)","v":67}]
["BMI","28.6 ± 3.7",null,"27.7 ± 2.6"]
["Age","65.6 ± 6.5",null,"64.4 ± 7.5"]
["Stages"]
["T1",1,{"$nulls":3},{"$f":"SUM(B51:E51)","v":1}]
["T2",33,null,13,null,46]
["T3",15,null,3,null,18]
["T4","-","-","-","-","-"]
["Tx",null,null,1,null,1]
["n.a.",1,{"$nulls":3},1]
["N0",11,null,5,null,16]
["N1",3,{"$nulls":3},3]
["N2","-","-","-","-","-"]
["Nx",36,null,12,null,48]
["n.a.","-","-","-","-","-"]
["M0",9,null,3,null,12]
["M1","-","-","-","-","-"]
["Mx",41,null,14,null,55]
["n.a.","-","-","-","-","-"]
["TOTAL",{"$f":"SUM(B5,B8,B28,B47)","v":174},{"$f":"SUM(C5,C8,C28,C47)","v":170},81,{"$f":"SUM(E5,E8,E28,E47)","v":56},{"$f":"SUM(B66:E66)","v":481}]
[]
["BMI - Body mass index"]
["F - Female"]
["M - Male"]
["N - Normal"]
["T - Tumor"]
["x - cannot be measured"]
["n.a. - not assigned"]

{"sheet":"Table 2","index":1,"n_rows":494,"n_cols":14,"rows_kept":494}
["Supplementary Table 2. Clinical information for all samples used in this study."]
[]
["Sample no.","Sample group","State","Age","Gender","Type of set","Type of tumor","Tumor (T)","Node (N)","Metastasis (M)","Grade (G)","BMI","Sequence code","Extraction code"]
["PA002","Healthy","N",40,"F","Tr","-","-","-","-","-",21.8,484,16]
["PA003","Healthy","N",47,"F","Tr","-","-","-","-","-",24.5,492,24]
["PA004","Healthy","N",40,"F","Tr","-","-","-","-","-",18.7,500,32]
["PA006","Healthy","N",43,"F","Tr","-","-","-","-","-",23.5,518,48]
["PA007","Healthy","N",63,"F","Tr","-","-","-","-","-",20.5,528,56]
["PA008","Healthy","N",61,"F","Tr","-","-","-","-","-",30.4,536,64]
["PA012","Healthy","N",32,"F","Tr","-","-","-","-","-",34.8,572,96]
["PA014","Healthy","N",40,"F","Tr","-","-","-","-","-",24.7,586,112]
["PA015","Healthy","N",40,"F","Tr","-","-","-","-","-",25.2,433,120]
["PA017","Healthy","N",54,"F","Tr","-","-","-","-","-",25.7,447,136]
["PA020","Healthy","N",43,"F","Tr","-","-","-","-","-",19.1,470,160]
["PA021","Healthy","N",32,"F","Tr","-","-","-","-","-",22.3,391,168]
["PA023","Healthy","N",40,"F","Tr","-","-","-","-","-",21.6,405,184]
["PA024","Healthy","N",37,"F","Tr","-","-","-","-","-",23.4,414,192]
["PA034","Healthy","N",32,"F","Tr","-","-","-","-","-",24.3,48,198]
["PA028","Healthy","N",43,"F","Tr","-","-","-","-","-",26.2,8,216]
["PA030","Healthy","N",47,"F","Tr","-","-","-","-","-",23.6,20,228]
["PA033","Healthy","N",26,"F","Tr","-","-","-","-","-",18.9,40,246]
["PA037","Healthy","N",44,"F","Tr","-","-","-","-","-",20.76,66,465]
["PA038","Healthy","N",57,"F","Tr","-","-","-","-","-",22.99,74,466]
["PA040","Healthy","N",54,"F","Tr","-","-","-","-","-",26.64,85,468]
["PA043","Healthy","N",66,"F","Tr","-","-","-","-","-",25.78,102,471]
["PA046","Healthy","N",63,"F","Tr","-","-","-","-","-",24.17,158,473]
["PA048","Healthy","N",31,"F","Tr","-","-","-","-","-",21.46,114,475]
["PA050","Healthy","N",44,"F","Tr","-","-","-","-","-",26.45,124,477]
["PA053","Healthy","N",55,"F","Tr","-","-","-","-","-",21.26,141,480]
["PA055","Healthy","N",54,"F","Tr","-","-","-","-","-",28.73,151,481]
["PA058","Healthy","N",62,"F","Tr","-","-","-","-","-",28.63,173,484]
["PA059","Healthy","N",48,"F","Tr","-","-","-","-","-",29.37,180,485]
["PA060","Healthy","N",79,"F","Tr","-","-","-","-","-",21.88,185,486]
["PA066","Healthy","N",39,"F","Tr","-","-","-","-","-",22.2,207,490]
["PA067","Healthy","N",52,"F","Tr","-","-","-","-","-",22.72,212,491]
["PA068","Healthy","N",63,"F","Tr","-","-","-","-","-",26.2,216,492]
["PA072","Healthy","N",45,"F","Tr","-","-","-","-","-",28.03,234,496]
["PA073","Healthy","N",72,"F","Tr","-","-","-","-","-",31.14,238,497]
["PA075","Healthy","N",57,"F","Tr","-","-","-","-","-",23.44,241,498]
["PA078","Healthy","N",52,"F","Tr","-","-","-","-","-",27.51,252,501]
["PA080","Healthy","N",28,"F","Tr","-","-","-","-","-",26.83,258,503]
["PA084","Healthy","N",73,"F","Tr","-","-","-","-","-",25.1,269,506]
["PA087","Healthy","N",54,"F","Tr","-","-","-","-","-",23.78,278,509]
["PA089","Healthy","N",54,"F","Tr","-","-","-","-","-",28.23,284,511]
["PA091","Healthy","N",52,"F","Tr","-","-","-","-","-",18.83,292,513]
["PA096","Healthy","N",67,"F","Tr","-","-","-","-","-",25.71,304,517]
["PA103","Healthy","N",54,"F","Tr","-","-","-","-","-",20.7,327,524]
["PA105","Healthy","N",39,"F","Tr","-","-","-","-","-",21.26,335,526]
["PA107","Healthy","N",66,"F","Tr","-","-","-","-","-",34.15,341,528]
["PA109","Healthy","N",67,"F","Tr","-","-","-","-","-",23.05,347,530]
["PA110","Healthy","N",67,"F","Tr","-","-","-","-","-",26.26,350,531]
["PA116","Healthy","N",71,"F","Tr","-","-","-","-","-",22.99,365,537]
["PA119","Healthy","N",73,"F","Tr","-","-","-","-","-",20.2,371,540]
["PA122","Healthy","N",59,"F","Tr","-","-","-","-","-",29.74,378,543]
["DV158","Healthy","N",{"v":61.3,"d":"61"},"F","Tr","-","-","-","-","-","-",489,10]
["DV159","Healthy","N",{"v":48.8,"d":"49"},"F","Tr","-","-","-","-","-","-",497,18]
["DV160","Healthy","N",{"v":47.6,"d":"48"},"F","Tr","-","-","-","-","-","-",507,26]
["DV162","Healthy","N",{"v":59.9,"d":"60"},"F","Tr","-","-","-","-","-",25.39,523,42]
["DV163","Healthy","N",{"v":42.5,"d":"43"},"F","Tr","-","-","-","-","-","-",533,50]
["DV164","Healthy","N",{"v":53.4,"d":"53"},"F","Tr","-","-","-","-","-","-",541,58]
["DV166","Healthy","N",{"v":68.3,"d":"68"},"F","Tr","-","-","-","-","-","-",559,74]
["DV168","Healthy","N",{"v":39.4,"d":"39"},"F","Tr","-","-","-","-","-",28,576,90]
["DV171","Healthy","N",{"v":54.8,"d":"55"},"F","Tr","-","-","-","-","-",26.5,437,114]
["DV175","Healthy","N",{"v":52.7,"d":"53"},"F","Tr","-","-","-","-","-",28,467,146]
["DV176","Healthy","N",{"v":57.3,"d":"57"},"F","Tr","-","-","-","-","-",22.1,388,154]
["DV177","Healthy","N",{"v":55.3,"d":"55"},"F","Tr","-","-","-","-","-",27.4,395,162]
["DV181","Healthy","N",{"v":53.7,"d":"54"},"F","Tr","-","-","-","-","-",31.64,424,194]
["DV182","Healthy","N",{"v":54.5,"d":"55"},"F","Tr","-","-","-","-","-",38.2,5,200]
["DV183","Healthy","N",{"v":37.3,"d":"37"},"F","Tr","-","-","-","-","-",26.23,11,206]
["DV186","Healthy","N",{"v":56.2,"d":"56"},"F","Tr","-","-","-","-","-",29.41,31,224]
["DV190","Healthy","N",{"v":45.5,"d":"46"},"F","Tr","-","-","-","-","-",23.3,57,248]
["DV191","Healthy","N",{"v":38.4,"d":"38"},"F","Tr","-","-","-","-","-",29,63,253]
["DV196","Healthy","N",46,"F","Tr","-","-","-","-","-",24.45,95,277]
["DV197","Healthy","N",{"v":45.1,"d":"45"},"F","Tr","-","-","-","-","-",24.5,100,281]
["DV201","Healthy","N",{"v":54.2,"d":"54"},"F","Tr","-","-","-","-","-",33.1,122,297]
["DV211","Healthy","N",{"v":51.2,"d":"51"},"F","Tr","-","-","-","-","-",23.71,176,337]
["DV213","Healthy","N",{"v":53.5,"d":"54"},"F","Tr","-","-","-","-","-",30.12,188,345]
["DV214","Healthy","N",{"v":40.9,"d":"41"},"F","Tr","-","-","-","-","-",23.4,193,349]
["PA001","Healthy","N",60,"F","Val","-","-","-","-","-",31.4,476,8]
["PA005","Healthy","N",60,"F","Val","-","-","-","-","-",27.6,510,40]
["PA011","Healthy","N",62,"F","Val","-","-","-","-","-",24.3,562,88]
["PA016","Healthy","N",43,"F","Val","-","-","-","-","-",24.6,440,128]
["PA022","Healthy","N",45,"F","Val","-","-","-","-","-",28.9,398,176]
["PA026","Healthy","N",56,"F","Val","-","-","-","-","-","-",421,204]
["PA035","Healthy","N",58,"F","Val","-","-","-","-","-",25.71,54,463]
["PA041","Healthy","N",44,"F","Val","-","-","-","-","-",23.88,92,469]
["PA052","Healthy","N",60,"F","Val","-","-","-","-","-",23.42,136,478]
["PA057","Healthy","N",27,"F","Val","-","-","-","-","-",17.58,168,483]
["PA063","Healthy","N",59,"F","Val","-","-","-","-","-",29.05,195,488]
["PA071","Healthy","N",65,"F","Val","-","-","-","-","-",38.1,230,495]
["PA077","Healthy","N",53,"F","Val","-","-","-","-","-",30.12,249,500]
["PA086","Healthy","N",45,"F","Val","-","-","-","-","-",21.14,275,508]
["PA092","Healthy","N",74,"F","Val","-","-","-","-","-",23.83,295,514]
["PA106","Healthy","N",73,"F","Val","-","-","-","-","-",28.23,338,527]
["PA114","Healthy","N",42,"F","Val","-","-","-","-","-",16.67,361,535]
["PA127","Healthy","N",38,"F","Val","-","-","-","-","-",20.86,383,548]
["DV161","Healthy","N",{"v":56.9,"d":"57"},"F","Val","-","-","-","-","-","-",515,34]
["DV165","Healthy","N",58,"F","Val","-","-","-","-","-","-",551,66]
["DV173","Healthy","N",{"v":47.1,"d":"47"},"F","Val","-","-","-","-","-",38,453,130]
["DV180","Healthy","N",{"v":34.2,"d":"34"},"F","Val","-","-","-","-","-",24,418,186]
["DV185","Healthy","N",{"v":59.1,"d":"59"},"F","Val","-","-","-","-","-","-",25,218]
["DV192","Healthy","N",{"v":29.5,"d":"30"},"F","Val","-","-","-","-","-",22,71,258]
["DV209","Healthy","N",{"v":46.2,"d":"46"},"F","Val","-","-","-","-","-",20,166,329]
["PA010","Healthy","N",47,"M","Tr","-","-","-","-","-",27.7,554,80]
["PA013","Healthy","N",44,"M","Tr","-","-","-","-","-",26.5,579,104]
["PA018","Healthy","N",42,"M","Tr","-","-","-","-","-",27.7,456,144]
["PA027","Healthy","N",46,"M","Tr","-","-","-","-","-",29.1,427,210]
["PA029","Healthy","N",48,"M","Tr","-","-","-","-","-",26.5,14,222]
["PA031","Healthy","N",66,"M","Tr","-","-","-","-","-",31.2,28,234]
["PA036","Healthy","N",58,"M","Tr","-","-","-","-","-",33.17,60,464]
["PA039","Healthy","N",63,"M","Tr","-","-","-","-","-",26.23,80,467]
["PA042","Healthy","N",51,"M","Tr","-","-","-","-","-",34.66,97,470]
["PA049","Healthy","N",38,"M","Tr","-","-","-","-","-",21.5,119,474]
["PA051","Healthy","N",65,"M","Tr","-","-","-","-","-",26.3,129,476]
["PA054","Healthy","N",27,"M","Tr","-","-","-","-","-",24.3,146,479]
["PA061","Healthy","N",59,"M","Tr","-","-","-","-","-",25.08,190,487]
["PA065","Healthy","N",65,"M","Tr","-","-","-","-","-",25.45,202,489]
["PA069","Healthy","N",45,"M","Tr","-","-","-","-","-",28.09,220,493]
["PA076","Healthy","N",64,"M","Tr","-","-","-","-","-",24.72,246,499]
["PA079","Healthy","N",25,"M","Tr","-","-","-","-","-",30.72,255,502]
["PA081","Healthy","N",77,"M","Tr","-","-","-","-","-",23.94,261,504]
["PA085","Healthy","N",76,"M","Tr","-","-","-","-","-",28.38,272,507]
["PA088","Healthy","N",54,"M","Tr","-","-","-","-","-",25.68,281,510]
["PA090","Healthy","N",56,"M","Tr","-","-","-","-","-",33.95,289,512]
["PA094","Healthy","N",71,"M","Tr","-","-","-","-","-",27.44,301,516]
["PA097","Healthy","N",69,"M","Tr","-","-","-","-","-",24.84,307,518]
["PA098","Healthy","N",52,"M","Tr","-","-","-","-","-",25.83,312,519]
["PA100","Healthy","N",53,"M","Tr","-","-","-","-","-",24.69,318,521]
["PA101","Healthy","N",67,"M","Tr","-","-","-","-","-",28.07,321,522]
["PA102","Healthy","N",61,"M","Tr","-","-","-","-","-",30.47,324,523]
["PA108","Healthy","N",70,"M","Tr","-","-","-","-","-",25.36,344,529]
["PA111","Healthy","N",69,"M","Tr","-","-","-","-","-",25.86,355,532]
["PA112","Healthy","N",47,"M","Tr","-","-","-","-","-",25.64,357,533]
["PA115","Healthy","N",46,"M","Tr","-","-","-","-","-",19.94,363,536]
["PA117","Healthy","N",73,"M","Tr","-","-","-","-","-",25.68,367,538]
["PA118","Healthy","N",51,"M","Tr","-","-","-","-","-",24.11,369,539]
["PA121","Healthy","N",66,"M","Tr","-","-","-","-","-",29.4,377,542]
["PA123","Healthy","N",55,"M","Tr","-","-","-","-","-",30.76,379,544]
["PA124","Healthy","N",50,"M","Tr","-","-","-","-","-",28.04,380,545]
["PA126","Healthy","N",39,"M","Tr","-","-","-","-","-",25.66,382,547]
["DV157","Healthy","N",{"v":50.3,"d":"50"},"M","Tr","-","-","-","-","-","-",481,2]
["DV167","Healthy","N",{"v":53.6,"d":"54"},"M","Tr","-","-","-","-","-",27.5,567,82]
["DV170","Healthy","N",{"v":54.6,"d":"55"},"M","Tr","-","-","-","-","-",26.79,430,106]
["DV172","Healthy","N",{"v":48.9,"d":"49"},"M","Tr","-","-","-","-","-",30.42,444,122]
["DV174","Healthy","N",{"v":60.6,"d":"61"},"M","Tr","-","-","-","-","-",29.06,460,138]
["DV179","Healthy","N",{"v":58.5,"d":"59"},"M","Tr","-","-","-","-","-",35.19,411,178]
["DV184","Healthy","N",52,"M","Tr","-","-","-","-","-","-",17,212]
["DV187","Healthy","N",{"v":58.7,"d":"59"},"M","Tr","-","-","-","-","-",25.9,37,230]
["DV189","Healthy","N",{"v":43.5,"d":"44"},"M","Tr","-","-","-","-","-",23,51,242]
["DV193","Healthy","N",{"v":43.6,"d":"44"},"M","Tr","-","-","-","-","-",29.8,77,263]
["DV194","Healthy","N",{"v":54.9,"d":"55"},"M","Tr","-","-","-","-","-",24.49,83,268]
["DV198","Healthy","N",{"v":43.9,"d":"44"},"M","Tr","-","-","-","-","-",25.66,105,285]
["DV199","Healthy","N",{"v":59.1,"d":"59"},"M","Tr","-","-","-","-","-",21.7,110,289]
["DV200","Healthy","N",{"v":43.6,"d":"44"},"M","Tr","-","-","-","-","-",27.2,117,293]
["DV203","Healthy","N",45,"M","Tr","-","-","-","-","-",23.55,132,305]
["DV204","Healthy","N",{"v":53.2,"d":"53"},"M","Tr","-","-","-","-","-",24.11,139,309]
["DV205","Healthy","N",{"v":39.7,"d":"40"},"M","Tr","-","-","-","-","-","-",144,313]
["DV207","Healthy","N",{"v":40.2,"d":"40"},"M","Tr","-","-","-","-","-",28.4,154,321]
["DV208","Healthy","N",{"v":64.4,"d":"64"},"M","Tr","-","-","-","-","-",34.29,161,325]
["DV210","Healthy","N",{"v":54.2,"d":"54"},"M","Tr","-","-","-","-","-",26.3,171,333]
["DV215","Healthy","N",{"v":44.5,"d":"45"},"M","Tr","-","-","-","-","-",25.38,198,353]
["DV216","Healthy","N",{"v":36.3,"d":"36"},"M","Tr","-","-","-","-","-",24.82,205,357]
["DV217","Healthy","N",{"v":63.5,"d":"64"},"M","Tr","-","-","-","-","-",15.96,210,361]
["PA009","Healthy","N",65,"M","Val","-","-","-","-","-",32.6,544,72]
["PA019","Healthy","N",38,"M","Val","-","-","-","-","-",24.2,463,152]
["PA032","Healthy","N",43,"M","Val","-","-","-","-","-",25.7,34,240]
["PA045","Healthy","N",33,"M","Val","-","-","-","-","-",21.45,107,472]
["PA056","Healthy","N",43,"M","Val","-","-","-","-","-",37.13,163,482]
["PA070","Healthy","N",63,"M","Val","-","-","-","-","-",29.65,226,494]
["PA083","Healthy","N",63,"M","Val","-","-","-","-","-",26.28,264,505]
["PA093","Healthy","N",74,"M","Val","-","-","-","-","-",24.31,298,515]
["PA099","Healthy","N",54,"M","Val","-","-","-","-","-",28.73,315,520]
["PA104","Healthy","N",50,"M","Val","-","-","-","-","-",27.76,330,525]
["PA113","Healthy","N",64,"M","Val","-","-","-","-","-",33.2,359,534]
["PA120","Healthy","N",60,"M","Val","-","-","-","-","-",23.29,373,541]
["PA125","Healthy","N",45,"M","Val","-","-","-","-","-",32.74,381,546]
["DV169","Healthy","N",{"v":33.4,"d":"33"},"M","Val","-","-","-","-","-",29.63,583,98]
["DV178","Healthy","N",{"v":38.6,"d":"39"},"M","Val","-","-","-","-","-",28.98,402,170]
["DV188","Healthy","N",{"v":46.6,"d":"47"},"M","Val","-","-","-","-","-",32.6,43,236]
["DV195","Healthy","N",{"v":55.6,"d":"56"},"M","Val","-","-","-","-","-",27.43,88,273]
["DV202","Healthy","N",{"v":59.2,"d":"59"},"M","Val","-","-","-","-","-","-",127,301]
["DV206","Healthy","N",{"v":52.4,"d":"52"},"M","Val","-","-","-","-","-","-",149,317]
["DV212","Healthy","N",{"v":29.8,"d":"30"},"M","Val","-","-","-","-","-",25.45,183,341]
["ExP01","Healthy","N",{"v":43.2,"d":"43"},"M","Val","-","-","-","-","-",28.81,478,6]
["ExP02","Healthy","N",{"v":59.9,"d":"60"},"M","Val","-","-","-","-","-",22.75,486,14]
["ExP06","Healthy","N",{"v":42.6,"d":"43"},"M","Val","-","-","-","-","-",26.47,520,46]
["ExP07","Healthy","N",{"v":44.8,"d":"45"},"M","Val","-","-","-","-","-",24.96,530,54]
["ExP08","Healthy","N",{"v":48.6,"d":"49"},"M","Val","-","-","-","-","-",21.3,538,62]
["ExP09","Healthy","N",{"v":42.2,"d":"42"},"M","Val","-","-","-","-","-",23.77,548,70]
["ExP11","Healthy","N",{"v":49.9,"d":"50"},"M","Val","-","-","-","-","-",29.91,564,86]
["ExP12","Healthy","N",{"v":50.1,"d":"50"},"M","Val","-","-","-","-","-",28.31,574,94]
["ExP13","Healthy","N",{"v":51.3,"d":"51"},"M","Val","-","-","-","-","-",29.4,581,102]
["ExP16","Healthy","N",{"v":55.1,"d":"55"},"M","Val","-","-","-","-","-",28.39,442,126]
["ExP17","Healthy","N",49,"M","Val","-","-","-","-","-",25.34,449,134]
["ExP18","Healthy","N",{"v":43.6,"d":"44"},"M","Val","-","-","-","-","-",26.3,458,142]
["DV219P","Breast","T",0,"F","Tr","-","pT1c","N0","Mx","G1",32.46,483,11]
["DV220P","Breast","T",68,"F","Tr","-","pT1c","pN0","pMx","G2",36.17,491,19]
["DV221P","Breast","T",67,"F","Tr","-","-","-","-","-",28.4,499,27]
["DV223P","Breast","T",58,"F","Tr","-","pTis","N0","-","G1",30.12,517,43]
["DV224P","Breast","T",69,"F","Tr","-","pT1b","N0","Mx","G1",28.34,527,51]
["DV225P","Breast","T",52,"F","Tr","-","pT1b","pN1a","pMx","G2",25.31,535,59]
["DV227P","Breast","T",34,"F","Tr","-","pT1c","pN0 (sn)","pMx","G3",21.16,553,75]
["DV228P","Breast","T",66,"F","Tr","-","-","-","-","G1",28.2,561,83]
["DV229P","Breast","T",60,"F","Tr","-","pT1c","pN0","pMx","G1",26.5,571,91]
["DV231P","Breast","T",57,"F","Tr","-","pT1b","pNx","pMx","G3",22.06,585,107]
["DV232P","Breast","T",65,"F","Tr","-","pTis","-","-","G1-2",16.42,432,115]
["DV233P","Breast","T",63,"F","Tr","-","-","-","-","G3",32.05,439,123]
["DV235P","Breast","T",64,"F","Tr","-","-","-","-",null,23.88,455,139]
["DV236P","Breast","T",67,"F","Tr","-","pT1c","pN1",null,"G2",29.41,462,147]
["DV237P","Breast","T",69,"F","Tr","-","pT1c","pN0(sn)","pMx","G1",24.34,469,155]
["DV239P","Breast","T",48,"F","Tr","-","-","-","-","-",null,397,171]
["DV240P","Breast","T",46,"F","Tr","-","ypR1","ypN0(0/8)","ypMx","G2",25.82,404,179]
["DV242P","Breast","T",59,"F","Tr","-","-","-","-","G3",31.6,420,195]
["DV244P","Breast","T",50,"F","Tr","-","pT1mi","N0","-","G3",26.44,7,207]
["DV245P","Breast","T",60,"F","Tr","-","pT1c","pN0","pMx","G1",36.17,13,213]
["DV246P","Breast","T",48,"F","Tr","-","pT1b","pN(sn)0","pMx","G1",23.8,19,219]
["DV248P","Breast","T",57,"F","Tr","-","-","-","-","-",27.45,33,231]
["DV249P","Breast","T",59,"F","Tr","-","pT1a","pN0","pMx","G2",32.37,39,237]
["DV250P","Breast","T",35,"F","Tr","-","pT1c","pN2","apMx","G2",22.27,47,243]
["DV252P","Breast","T",62,"F","Tr","-","pT1c","N0","Mx","G3",21.19,59,254]
["DV253P","Breast","T",73,"F","Tr","-","pTis","N0","Mx","G2-3",23.42,65,259]
["DV254P","Breast","T",74,"F","Tr","-","pT1b + pTis","pN(2xsn)0","pMx","G2-3",27.89,73,264]
["DV256P","Breast","T",51,"F","Tr","-","pT1c","pN0","pMx","G1",33.86,84,274]
["DV257P","Breast","T",40,"F","Tr","-","-","-","-","-",18.59,91,278]
["DV258P","Breast","T",64,"F","Tr","-","pT1c","-","-","G1",35.99,96,282]
["DV260P","Breast","T",61,"F","Tr","-","ypR1","ypN2(4/8)","ypMx","G1",36.23,106,290]
["DV261P","Breast","T",42,"F","Tr","-","pT1c","pN1","pMx","G1",20.82,113,294]
["DV262P","Breast","T",55,"F","Tr","-","-","-","-","G2",null,118,298]
["DV265P","Breast","T",66,"F","Tr","-","pT1b","pN(1+1sn)0","pMx","G1",24.84,135,310]
["DV266P","Breast","T",66,"F","Tr","-","pTis","pN(sn)0","pMx","G1-2",24.61,140,314]
["DV267P","Breast","T",60,"F","Tr","-","pT1b","pN0","pMx","G1",26.37,145,318]
["DV270P","Breast","T",66,"F","Tr","-","pT1c","pN0(2sn)","pMx","G2",28.13,162,330]
["DV271P","Breast","T",52,"F","Tr","-","-","-","-","-",25.39,167,334]
["DV274P","Breast","T",52,"F","Tr","-","pT1b","pN1","pMx","G2",21.48,184,346]
["DV276P","Breast","T",64,"F","Tr","-","pT1b","N0","-","G1",28.58,194,354]
["DV277P","Breast","T",65,"F","Tr","-","pT1c","N0(SLU)","Mx","G1",38.67,201,358]
["DV278P","Breast","T",66,"F","Tr","-","pT1b","pN0","pMx","G1",28.44,206,362]
["DV280P","Breast","T",68,"F","Tr","-","pTis","pN0(0/1-sn)","-","G3",null,215,368]
["DV281P","Breast","T",51,"F","Tr","-","pT1c","pN0","-","G2",21.77,219,371]
["DV282P","Breast","T",50,"F","Tr","-","pT1c","N0(SLU)","Mx","G2",26.17,225,374]
["DV284P","Breast","T",62,"F","Tr","-","ypR2","ypN1a(3/6)","ypMx","G3",33.66,233,380]
["DV287","Breast","T",67,"F","Tr","-","pT2","pN0(2SN)","pMx","G1",21.05,245,387]
["DV289","Breast","T",59,"F","Tr","-","pT1b","pN0(SLU)","pMx","G1",22.83,251,391]
["DV291","Breast","T",60,"F","Tr","-","pT1c","pN(sn)0","pMx","G2",22.84,257,395]
["DV292","Breast","T",75,"F","Tr","-","pT1b","pN0 (0/4)","pMx","G1",24,260,397]
["DV293","Breast","T",49,"F","Tr","-","ypT2","pN0","pMx","G2",23.72,263,399]
["DV295","Breast","T",64,"F","Tr","-","pT1c","pN(sn+axillary)0","pMx","G1",26.77,271,403]
["DV296","Breast","T",64,"F","Tr","-","pTis","pN0(0/6)","pMx","G2-3",25.01,274,405]
["DV297","Breast","T",54,"F","Tr","-","pT1c","pN0","pMx","G2",25.33,277,407]
["DV299","Breast","T",64,"F","Tr","-","pT1c","pN0(2SLU)","-","G2",30.49,283,411]
["DV300","Breast","T",43,"F","Tr","-","pT1c","pN0","-","G1",21.22,286,413]
["DV301","Breast","T",65,"F","Tr","-","pT1b","pN(sn)0","pMx","G2",27.72,291,415]
["DV303","Breast","T",45,"F","Tr","-","pT2m","pN0(sn)","-","G3",20.28,297,419]
["DV304","Breast","T",76,"F","Tr","-","-","-","-","pN0",18.83,300,421]
["DV305","Breast","T",59,"F","Tr","-","pT1c","N0","Mx","G2",26.22,303,423]
["DV307","Breast","T",52,"F","Tr","-","-","-","-","-",14.53,311,427]
["DV308","Breast","T",52,"F","Tr","-","pT1c","pN0(0/3)","pMx","G1",21.56,314,429]
["DV309","Breast","T",65,"F","Tr","-","pT1c","N0","Mx","G3",31.4,317,431]
["DV311","Breast","T",77,"F","Tr","-","pT1b","pN0(sn)","pMx","G2",32.11,323,435]
["DV312","Breast","T",67,"F","Tr","-","pTis","pN(sn)0","pMx","-",30.3,326,437]
["DV313","Breast","T",61,"F","Tr","-","-","-","-","-",25.43,329,439]
["DV316","Breast","T",66,"F","Tr","-","pT1b","pN1(1/2)","pMx","G1",30.49,340,445]
["DV317","Breast","T",42,"F","Tr","-","pT1c","N0(SLU)","Mx","G2-3",41.45,343,447]
["DV318","Breast","T",59,"F","Tr","-","pT1c","N0","-","G2",24.68,346,449]
["DV320","Breast","T",62,"F","Tr","-","pT1c","N0","Mx","G3",null,352,453]
["DV218P","Breast","T",42,"F","Val","-","pT1c","pN0","pMx","G3",20.83,475,3]
["DV222P","Breast","T",69,"F","Val","-","pT1b","N0 (sentinel)","Mx","G1",26.08,509,35]
["DV226P","Breast","T",54,"F","Val","-","pT1c","pN1 (mi)(sn)","pMx","G2",23.05,543,67]
["DV230P","Breast","T",67,"F","Val","-","pT1b","pN(2xsn)0","pMx","G1",null,578,99]
["DV234P","Breast","T",58,"F","Val","-","pT1b","pN1","pMx","G1",37.34,446,131]
["DV238P","Breast","T",68,"F","Val","-","-","-","-","G2-3",25.35,390,163]
["DV243P","Breast","T",63,"F","Val","-","pT1c","pN0(sn)","pMx","G2",37.34,426,201]
["DV247P","Breast","T",65,"F","Val","-","pT1c","pN0","pMx","G1",31.63,27,225]
["DV251P","Breast","T",46,"F","Val","-","pT1c","pN2","apMx","G3",20.2,53,249]
["DV255P","Breast","T",86,"F","Val","-","pTis + pT1c + pPn1","pN(2xsn)0","pMx","G2-3",24.14,79,269]
["DV259P","Breast","T",50,"F","Val","-","ypT2","ypN0(2sn)","ypMx","G2",32.32,101,286]
["DV263P","Breast","T",50,"F","Val","-","pT1a","N0","Mx","G2",27.78,123,302]
["DV268P","Breast","T",68,"F","Val","-","-","-","-","-",31.16,150,322]
["DV275P","Breast","T",58,"F","Val","-","pT1b","pN0","pMx","G1",35,189,350]
["DV279P","Breast","T",72,"F","Val","-","pT1b","pN1","pMx","G3",null,211,365]
["DV283P","Breast","T",73,"F","Val","-","ypT1c","N0(SLU)","Mx","G2",null,229,377]
["DV290","Breast","T",83,"F","Val","-","ypT2","ypN1","-","G3",33.2,254,393]
["DV294","Breast","T",51,"F","Val","-","mpT1mi+pT1a","pN(sn)0","pMx","G2",25.39,268,401]
["DV298","Breast","T",66,"F","Val","-","pT1c","pN0(SLU)","pMx","G1",27.51,280,409]
["DV302","Breast","T",67,"F","Val","-","pT1c","pN0","pMx","-",43.36,294,417]
["DV306","Breast","T",70,"F","Val","-","pT2","pN1","mipMX","G2",41.33,306,425]
["DV310","Breast","T",63,"F","Val","-","-","-","-","-",24.44,320,433]
["DV315","Breast","T",42,"F","Val","-","pT1c","pN1(2/14)","pMx","G2",29.76,337,443]
["DV319","Breast","T",50,"F","Val","-","mpT1b","pN(sn)0","pMx","G3",22.49,349,451]
["DV241P","Breast","T",68,"M","Tr","-","T3-4","Nx","M1b","-",29.39,413,187]
["DV269P","Breast","T",73,"M","Tr","-","-","-","-","-",null,157,326]
["DV272P","Breast","T",60,"M","Tr","-","-","-","-","-",20.98,172,338]
["DV273P","Breast","T",70,"M","Tr","-","-","-","-","-",20.2,179,342]
["DV286P","Breast","T",58,"M","Tr","-","-","-","-","-",38.22,240,385]
["DV288","Breast","T",68,"M","Tr","-","-","-","-","-",19.25,248,389]
["DV314","Breast","T",66,"M","Tr","-","-","-","-","-",28.41,334,441]
["DV264P","Breast","T",70,"M","Val","-","-","-","-","-",24.49,128,306]
["DV285P","Breast","T",59,"M","Val","-","-","-","-","-",27.68,237,383]
["DV022","Kidney","T",{"v":56.3,"d":"56"},"F","Tr","ccRCC","pT1a","N0","M0","G2-4",29,529,49]
["DV025","Kidney","T",{"v":36.9,"d":"37"},"F","Tr","ccRCC","pT1a","N0","M0","G2",33,555,73]
["DV027","Kidney","T",{"v":52.6,"d":"53"},"F","Tr","ccRCC","pT3a","N0","M0","G3",31.5,573,89]
["DV041","Kidney","T",81,"F","Tr","ccRCC","pT2b","N0","M1","G2-3",28.04,415,185]
["DV045","Kidney","T",{"v":62.9,"d":"63"},"F","Tr","ccRCC","pT1b","N0","M0","G2",26.67,15,211]
["DV047","Kidney","T",{"v":72.8,"d":"73"},"F","Tr","ccRCC","pT2a","N0","M0","G3",20.7,29,223]
["DV050","Kidney","T",{"v":68.2,"d":"68"},"F","Tr","ccRCC","pT1b","N0","M0","G1-2",19.2,49,241]
["DV055","Kidney","T",{"v":59.7,"d":"60"},"F","Tr","ccRCC","pT3b","N0","M0","G3",31.64,81,267]
["DV057","Kidney","T",73,"F","Tr","ccRCC","pT1a","N0","M0","G2",28.01,93,276]
["DV064","Kidney","T",{"v":67.1,"d":"67"},"F","Tr","ccRCC","pT3a","N0","M0","G3","-",130,304]
["DV066","Kidney","T",64,"F","Tr","ccRCC","pT3a","N0","M0","G3",29.74,142,312]
["DV068","Kidney","T",78,"F","Tr","ccRCC","pT1b","N0","M0","G2",27.48,152,320]
["DV074","Kidney","T",{"v":44.4,"d":"44"},"F","Tr","ccRCC","pT1b","N0","M0","G1",21.45,186,344]
["DV077","Kidney","T",{"v":66.6,"d":"67"},"F","Tr","chromophobe-RCC","pT2a","N0","M0","Gx",30.12,203,356]
["DV078","Kidney","T",{"v":79.9,"d":"80"},"F","Tr","ccRCC","pT3a","N0","M0","G4",24.34,208,360]
["DV086","Kidney","T",{"v":58.6,"d":"59"},"F","Tr","ccRCC","pT1a","N0","M0","G1",23.8,242,384]
["DV098","Kidney","T",{"v":73.3,"d":"73"},"F","Tr","ccRCC (sarcomatoid)","pT3a","N0","M1","G4",36.39,279,406]
["DV101","Kidney","T",{"v":70.7,"d":"71"},"F","Tr","ccRCC","pT3a","N0","M0","G3",44.82,290,412]
["DV102","Kidney","T",{"v":73.1,"d":"73"},"F","Tr","ccRCC","pT3b","N1","M0","G3",21.09,293,414]
["DV107","Kidney","T",{"v":78.8,"d":"79"},"F","Tr","ccRCC","pT1a","N0","M0","G2",23.81,308,424]
["DV111","Kidney","T",{"v":68.2,"d":"68"},"F","Tr","ccRCC","pT2a","N0","M0","G1",34.53,322,432]
["DV112","Kidney","T",{"v":61.7,"d":"62"},"F","Tr","ccRCC","pT2a","N0","M0","G1-2",34.21,325,434]
["DV148","Kidney","T",{"v":59.6,"d":"60"},"F","Tr","ccRCC","pT1a","N0","M0","G2",27.22,1012,457]
["DV144","Kidney","T",{"v":45.3,"d":"45"},"F","Tr","adult cystic nephroma/multilocular cystic-RCC","-","-","-","-",18.31,490,452]
["DV150","Kidney","T",{"v":81.7,"d":"82"},"F","Tr","ccRCC","pT1b","N0","M0","G2",29.38,1014,459]
["DV020","Kidney","T",{"v":51.4,"d":"51"},"F","Val","ccRCC (sarcomatoid)","pT3","N1","M1","G4",15.79,511,33]
["DV035","Kidney","T",{"v":65.7,"d":"66"},"F","Val","ccRCC","pT1b","N0","M0","G2","-",457,137]
["DV048","Kidney","T",{"v":69.9,"d":"70"},"F","Val","ccRCC","pT1a","N0","M0","G2",26.81,35,229]
["DV059","Kidney","T",{"v":72.6,"d":"73"},"F","Val","ccRCC","pT1a","N0","M0","G2",31.25,103,284]
["DV090","Kidney","T",{"v":57.1,"d":"57"},"F","Val","chromophobe-RCC","pT2b","N0","M0","G3-4",24.03,256,392]
["DV105","Kidney","T",{"v":75.3,"d":"75"},"F","Val","ccRCC","pT1a","N0","M0","G2",30.86,302,420]
["DV152","Kidney","T",{"v":60.8,"d":"61"},"F","Val","ccRCC","pT1a","N0","M0","G2","-",1016,461]
["DV017","Kidney","T",{"v":80.1,"d":"80"},"M","Tr","ccRCC","pT3a","N0","M0","G2",27,485,9]
["DV018","Kidney","T",{"v":59.2,"d":"59"},"M","Tr","ccRCC","pT1a","N0","M0","G2",27.7,493,17]
["DV019","Kidney","T",{"v":75.5,"d":"76"},"M","Tr","ccRCC","pT3a","Nx","Mx","G2",34.4,501,25]
["DV023","Kidney","T",{"v":66.4,"d":"66"},"M","Tr","ccRCC","pT1b","N0","M0","G2","-",537,57]
["DV024","Kidney","T",{"v":80.9,"d":"81"},"M","Tr","ccRCC","pT1b","Nx","Mx","G2",18.93,545,65]
["DV026","Kidney","T",{"v":64.2,"d":"64"},"M","Tr","ccRCC","pT3a","N0","M0","G3",32.5,563,81]
["DV029","Kidney","T",{"v":63.1,"d":"63"},"M","Tr","ccRCC","pT1a","N0","M0","G1-2",27.3,587,105]
["DV030","Kidney","T",{"v":70.5,"d":"71"},"M","Tr","ccRCC","pT1b","N0","M0","G2",30.69,434,113]
["DV031","Kidney","T",{"v":60.3,"d":"60"},"M","Tr","ccRCC","pT3a","N0","M0","G2",35,441,121]
["DV036","Kidney","T",{"v":77.5,"d":"78"},"M","Tr","papillary-RCC","pT2a","N0","M0","G2",22.99,464,145]
["DV037","Kidney","T",{"v":65.7,"d":"66"},"M","Tr","ccRCC","pT3a","N1","M1","G2",28.38,471,153]
["DV040","Kidney","T",{"v":81.2,"d":"81"},"M","Tr","ccRCC","pT1a","N0","M0","G1",23.88,408,177]
["DV042","Kidney","T",{"v":54.9,"d":"55"},"M","Tr","ccRCC","pT2a","N0","M0","G2",27.08,422,193]
["DV043","Kidney","T",{"v":61.5,"d":"62"},"M","Tr","ccRCC","pT1b","N0","M0","G2",24.69,3,199]
["DV046","Kidney","T",{"v":54.9,"d":"55"},"M","Tr","ccRCC","pT1b","N0","M0","G2",22.64,21,217]
["DV049","Kidney","T",{"v":32.8,"d":"33"},"M","Tr","ccRCC","pT3a","N0","M0","G3",24.8,41,235]
["DV051","Kidney","T",{"v":71.1,"d":"71"},"M","Tr","ccRCC (sarcomatoid)","pT1b","N0","M0","G4",24.84,55,247]
["DV053","Kidney","T",{"v":51.8,"d":"52"},"M","Tr","ccRCC (sarcomatoid)","pT3a","N1","M1","G4",37.01,69,257]
["DV054","Kidney","T",{"v":75.1,"d":"75"},"M","Tr","papillary-RCC","pT3a","N0","M0","G3",24.91,75,262]
["DV056","Kidney","T",{"v":66.3,"d":"66"},"M","Tr","ccRCC","pT1b","N0","M0","G2",32.51,86,272]
["DV061","Kidney","T",{"v":50.2,"d":"50"},"M","Tr","ccRCC","pT3a","-","-","G2",33.21,115,292]
["DV062","Kidney","T",{"v":69.4,"d":"69"},"M","Tr","ccRCC","pT1a","N0","M0","G1",32.11,120,296]
["DV065","Kidney","T",{"v":44.7,"d":"45"},"M","Tr","ccRCC","pT1b","N0","M0","G1",35.65,137,308]
["DV067","Kidney","T",{"v":70.7,"d":"71"},"M","Tr","ccRCC","pT3a","N0","M0","G3",31.02,147,316]
["DV069","Kidney","T",{"v":59.2,"d":"59"},"M","Tr","ccRCC (sarcomatoid)","pT3a","Nx","M0","G4",24.78,159,324]
["DV071","Kidney","T",{"v":58.3,"d":"58"},"M","Tr","ccRCC","pT1a","N0","M0","G3",23.67,169,332]
["DV072","Kidney","T",{"v":67.9,"d":"68"},"M","Tr","ccRCC","pT1a","N0","M0","G2",35.64,174,336]
["DV073","Kidney","T",{"v":40.5,"d":"41"},"M","Tr","ccRCC","pT1b","N0","M0","G1",27.45,181,340]
["DV075","Kidney","T",{"v":77.2,"d":"77"},"M","Tr","ccRCC","pT1b","N0","M0","G2",31.14,191,348]
["DV076","Kidney","T",{"v":64.1,"d":"64"},"M","Tr","ccRCC","pT2b","N0","M0","G3",29.07,196,352]
["DV079","Kidney","T",{"v":62.7,"d":"63"},"M","Tr","ccRCC","pT3a","Nx","M1","G3",23.41,213,364]
["DV080","Kidney","T",{"v":67.9,"d":"68"},"M","Tr","chromophobe-RCC","pT2a","N0","M0","Gx",33.9,217,367]
["DV082","Kidney","T",{"v":68.1,"d":"68"},"M","Tr","ccRCC (sarcomatoid)","pT3a","Nx","M1","G4",25.35,227,373]
["DV083","Kidney","T",{"v":47.3,"d":"47"},"M","Tr","ccRCC","pT2a","N0","M0","G3",30.09,231,376]
["DV084","Kidney","T",{"v":64.1,"d":"64"},"M","Tr","ccRCC","pT3a","N0","M1","G4",22.09,235,379]
["DV087","Kidney","T",{"v":59.9,"d":"60"},"M","Tr","ccRCC","pT3a","N0","M0","G2",24.54,247,386]
["DV088","Kidney","T",{"v":56.1,"d":"56"},"M","Tr","ccRCC","pT1b","N0","M0","G2",26.6,250,388]
["DV089","Kidney","T",{"v":61.7,"d":"62"},"M","Tr","ccRCC","pT3a","N0","M0","G3",22.09,253,390]
["DV092","Kidney","T",{"v":71.9,"d":"72"},"M","Tr","ccRCC","pT3a","N1","M0","G3",21.72,262,396]
["DV093","Kidney","T",{"v":75.7,"d":"76"},"M","Tr","ccRCC","pT2a","N0","M0","G3",26.23,267,398]
["DV094","Kidney","T",{"v":61.1,"d":"61"},"M","Tr","ccRCC","pT3a","N0","M0","G3",27.64,270,400]
["DV097","Kidney","T",{"v":55.3,"d":"55"},"M","Tr","ccRCC (sarcomatoid)","pT3a","N0","M0","G4",28.53,276,404]
["DV099","Kidney","T",{"v":73.5,"d":"74"},"M","Tr","ccRCC","pT2a","N0","M0","G3",29.3,282,408]
["DV100","Kidney","T",{"v":50.5,"d":"51"},"M","Tr","ccRCC","pT1b","N0","M0","G1",34.48,285,410]
["DV104","Kidney","T",{"v":70.4,"d":"70"},"M","Tr","ccRCC","pT3a","N2","M1","G3",24.11,299,418]
["DV106","Kidney","T",{"v":40.6,"d":"41"},"M","Tr","ccRCC","pT3a","N0","M0","G3",36.57,305,422]
["DV110","Kidney","T",{"v":76.3,"d":"76"},"M","Tr","ccRCC","pT3a","N0","M0","G3",34.95,319,430]
["DV113","Kidney","T",{"v":77.3,"d":"77"},"M","Tr","ccRCC","pT3a","N0","M0","G2",20.42,328,436]
["DV114","Kidney","T",{"v":36.1,"d":"36"},"M","Tr","ccRCC","pT1b","N0","M0","G2",24.06,333,438]
["DV116","Kidney","T",82,"M","Tr","papillary-RCC","pT3a","N0","M0","G1",26.99,339,442]
["DV140","Kidney","T",70,"M","Tr","ccRCC","pT1a","N0","M0","G3",28.08,482,444]
["DV141","Kidney","T",{"v":77.8,"d":"78"},"M","Tr","ccRCC","pT3a","N0","M0","G2",32.11,484,446]
["DV143","Kidney","T",66,"M","Tr","ccRCC","pT1a","N0","M0","G3",27.72,488,450]
["DV146","Kidney","T",{"v":53.8,"d":"54"},"M","Tr","ccRCC","pT3a","N1","M1","G3",25.36,1010,455]
["DV149","Kidney","T",{"v":67.3,"d":"67"},"M","Tr","ccRCC","pTx","N0","M0","Gx",33.21,498,458]
["DV151","Kidney","T",{"v":44.6,"d":"45"},"M","Tr","ccRCC","pT1a","N0","M0","G2",28.38,500,460]
["DV153","Kidney","T",{"v":52.3,"d":"52"},"M","Tr","ccRCC","pT1b","Nx","Mx","G2",31.31,502,462]
["DV016","Kidney","T",{"v":70.7,"d":"71"},"M","Val","papillary-RCC","T1b","N0","M0","Gx",28.3,477,1]
["DV021","Kidney","T",{"v":82.3,"d":"82"},"M","Val","papillary-RCC","pT1a","Nx","Mx","Gx",27,519,41]
["DV028","Kidney","T",{"v":66.3,"d":"66"},"M","Val","ccRCC","pT2a","N0","M0","G1-2",27.4,580,97]
["DV033","Kidney","T",{"v":52.9,"d":"53"},"M","Val","ccRCC","pT1b","N0","M0","G2",22.64,448,129]
["DV039","Kidney","T",{"v":51.2,"d":"51"},"M","Val","ccRCC","pT1a","N0","M0","G2","-",399,169]
["DV044","Kidney","T",{"v":64.7,"d":"65"},"M","Val","ccRCC","pT1a","N0","M0","G2",21.33,9,205]
["DV052","Kidney","T",{"v":48.1,"d":"48"},"M","Val","ccRCC","pT3a","N0","M0","G2",27.77,61,252]
["DV058","Kidney","T",{"v":50.4,"d":"50"},"M","Val","ccRCC","pT3a","N0","M0","G2-3",27.47,98,280]
["DV063","Kidney","T",{"v":80.9,"d":"81"},"M","Val","ccRCC","pT3a","N0","M0","G3",23.66,125,300]
["DV070","Kidney","T",77,"M","Val","ccRCC","pT3a","N0","M0","G3",24.76,164,328]
["DV081","Kidney","T",{"v":53.2,"d":"53"},"M","Val","eosinophilic granular cell subform + ccRCC residuum","pT1b","N0","M0","G3",30.74,223,370]
["DV085","Kidney","T",{"v":58.6,"d":"59"},"M","Val","ccRCC","pT3a","N0","M0","G1-2",17.87,239,382]
["DV091","Kidney","T",69,"M","Val","papillary-RCC","pT2a","N0","M0","Gx",29.64,259,394]
["DV095","Kidney","T",{"v":69.9,"d":"70"},"M","Val","ccRCC","pT1b","N0","M0","G2",25.15,273,402]
["DV103","Kidney","T",{"v":72.7,"d":"73"},"M","Val","ccRCC","pT3a","N1","M1","G3",31.31,296,416]
["DV109","Kidney","T",{"v":65.3,"d":"65"},"M","Val","ccRCC","pT1b","N0","M0","G3",25.14,316,428]
["DV115","Kidney","T",{"v":55.7,"d":"56"},"M","Val","ccRCC","pT2b","N0","M0","G2",26.12,336,440]
["DV142","Kidney","T",{"v":72.2,"d":"72"},"M","Val","ccRCC (sarcomatoid)","pT3a","N1","M1","G4",32.14,486,448]
["DV145","Kidney","T",{"v":72.7,"d":"73"},"M","Val","ccRCC","pT1a","N0","M0","G1",29.94,494,454]
["DV147","Kidney","T",{"v":55.3,"d":"55"},"M","Val","papillary-RCC","pT1a","N0","M0","G2",31.48,496,456]
["ExP03","Kidney","T",{"v":49.1,"d":"49"},"M","Val","ccRCC","pT1a","Nx","Mx","G1",27.78,494,22]
["ExP04","Kidney","T",{"v":47.8,"d":"48"},"M","Val","multilocular cystic-RCC","pT1b","Nx","Mx","Gx",26,504,30]
["ExP05","Kidney","T",{"v":57.2,"d":"57"},"M","Val","papillary-RCC","pT1a","Nx","Mx","G2",27.47,512,38]
["ExP14","Kidney","T",{"v":55.1,"d":"55"},"M","Val","ccRCC","pT3a","Nx","Mx","G4",29.03,588,110]
["ExP15","Kidney","T",{"v":59.9,"d":"60"},"M","Val","ccRCC","pT4","Nx","Mx","G3",26.04,435,118]
["ExP19","Kidney","T",{"v":60.7,"d":"61"},"M","Val","ccRCC","pT1a","Nx","Mx","G2",29.26,465,150]
["ExP20","Kidney","T",{"v":52.5,"d":"53"},"M","Val","ccRCC, multilocular cystic-RCC","pT1a","Nx","Mx","G1",22.7,386,158]
["ExP22","Kidney","T",{"v":60.2,"d":"60"},"M","Val","multilocular cystic-RCC","pT1a","Nx","Mx","Gx",32.95,400,174]
["ExP23","Kidney","T",{"v":59.8,"d":"60"},"M","Val","chromophobe-RCC","pT3a","Nx","Mx","Gx",30.93,409,182]
["ExP24","Kidney","T",{"v":53.7,"d":"54"},"M","Val","ccRCC","pT1b","Nx","Mx","Gx",31.46,416,190]
["DV463","Prostate","T",{"v":66.4,"d":"66"},"M","Tr","adenokarcinom","pTc2","Nx","Mx","G3+4",26.84,487,12]
["DV464","Prostate","T",{"v":64.6,"d":"65"},"M","Tr","adenokarcinom","pT2a","Nx","M0","G3+3",28.4,495,20]
["DV465","Prostate","T",{"v":64.8,"d":"65"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+4",27.78,505,28]
["DV467","Prostate","T",{"v":75.6,"d":"76"},"M","Tr","acinar adenocarcinoma","pT2c","N0","Mx","G4+4",25.01,521,44]
["DV468","Prostate","T",{"v":65.6,"d":"66"},"M","Tr","adenokarcinom","pT2b","Nx","Mx","G4+3",26.78,531,52]
["DV469","Prostate","T",{"v":73.4,"d":"73"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+4",29.76,539,60]
["DV471","Prostate","T",{"v":51.9,"d":"52"},"M","Tr","adenokarcinom","pT2a","N0","Mx","G4+3",24.91,557,76]
["DV472","Prostate","T",{"v":64.9,"d":"65"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+3",29.22,565,84]
["DV473","Prostate","T",{"v":77.3,"d":"77"},"M","Tr","adenokarcinom","pT3a","Nx","Mx","G4+4",33.03,575,92]
["DV475","Prostate","T",{"v":71.1,"d":"71"},"M","Tr","adenokarcinom","pT3b","Nx","Mx","G4+3",31.48,589,108]
["DV476","Prostate","T",{"v":70.4,"d":"70"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+4",21.98,436,116]
["DV477","Prostate","T",{"v":71.7,"d":"72"},"M","Tr","adenokarcinom","pT2a","Nx","Mx","G3+3",29.41,443,124]
["DV479","Prostate","T",{"v":69.5,"d":"70"},"M","Tr","adenokarcinom","pT2c","N0","Mx","G3+4",31.85,459,140]
["DV480","Prostate","T",{"v":58.6,"d":"59"},"M","Tr","adenokarcinom","pT2a","Nx","Mx","G3+4",25.65,466,148]
["DV481","Prostate","T",{"v":78.7,"d":"79"},"M","Tr","acinar adenocarcinoma","pT2c","Nx","Mx","G3+4",21.91,387,156]
["DV483","Prostate","T",{"v":65.6,"d":"66"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G4+4",29,401,172]
["DV484","Prostate","T",{"v":57.7,"d":"58"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+4",33.31,410,180]
["DV485","Prostate","T",{"v":58.4,"d":"58"},"M","Tr","adenokarcinom","pT2c","N0","Mx","G4+3",31.44,417,188]
["DV487","Prostate","T",{"v":71.4,"d":"71"},"M","Tr","adenokarcinom","-","Nx","Mx","G3+4",23.78,4,202]
["DV488","Prostate","T",{"v":54.2,"d":"54"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+4",25.61,10,208]
["DV489","Prostate","T",{"v":55.7,"d":"56"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+3",26.51,16,214]
["DV491","Prostate","T",66,"M","Tr","acinar adenocarcinoma","pT2c","Nx","Mx","G3+4",33.82,30,226]
["DV492","Prostate","T",{"v":72.8,"d":"73"},"M","Tr","adenokarcinom","pT3b","Nx","Mx","G4+5",28.73,36,232]
["DV493","Prostate","T",{"v":68.9,"d":"69"},"M","Tr","acinar adenocarcinoma","pT3a","Nx","Mx","G4+5+3",26.56,42,238]
["DV495","Prostate","T",{"v":60.4,"d":"60"},"M","Tr","adenokarcinom","pT3b","Nx","Mx","G4+5",26.12,56,250]
["DV496","Prostate","T",{"v":61.4,"d":"61"},"M","Tr","acinar adenocarcinoma","pT3","Nx","Mx","G4+4",24.62,62,255]
["DV497","Prostate","T",59,"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+3",26.59,70,260]
["DV499","Prostate","T",{"v":70.7,"d":"71"},"M","Tr","adenokarcinom","pT3a","N1","Mx","G4+3",23.45,82,270]
["DV500","Prostate","T",{"v":55.4,"d":"55"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+4",44.29,87,275]
["DV501","Prostate","T",{"v":69.2,"d":"69"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G4+3",29.63,94,279]
["DV503","Prostate","T",{"v":53.5,"d":"54"},"M","Tr","adenokarcinom","pT3a","Nx","Mx","G4+3+5",28.07,104,287]
["DV504","Prostate","T",{"v":72.1,"d":"72"},"M","Tr","adenokarcinom","pT3b","Nx","Mx","G3+4",30.47,109,291]
["DV505","Prostate","T",{"v":65.8,"d":"66"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","G3+4",25.25,116,295]
["DV507","Prostate","T",72,"M","Tr","adenokarcinom","pT1c","Nx","Mx","GS3+3",30.93,126,303]
["DV508","Prostate","T",{"v":62.6,"d":"63"},"M","Tr","adenokarcinom","pT3a","N0","M0","GS4+3",28.39,131,307]
["DV509","Prostate","T",{"v":66.3,"d":"66"},"M","Tr","adenokarcinom","pT2a","N0","M0","GS4+3",27.1,138,311]
["DV511","Prostate","T",{"v":59.2,"d":"59"},"M","Tr","adenokarcinom","pT2c","N0","M0","GS3+4",34.54,148,319]
["DV512","Prostate","T",{"v":59.1,"d":"59"},"M","Tr","adenokarcinom","pT2c","Nx","M0","Gx",29.4,153,323]
["DV513","Prostate","T",64,"M","Tr","adenokarcinom","pT2c","N0","M0","GS4+3",31.02,160,327]
["DV515","Prostate","T",{"v":71.4,"d":"71"},"M","Tr","adenokarcinom","pT3b","N0","M0","GS3+4",25.01,170,335]
["DV516","Prostate","T",{"v":72.9,"d":"73"},"M","Tr","adenokarcinom","pT3a","Nx","Mx","GS4+3",27.17,175,339]
["DV517","Prostate","T",{"v":62.4,"d":"62"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","GS3+4",30.67,182,343]
["DV519","Prostate","T",{"v":57.8,"d":"58"},"M","Tr","adenokarcinom","pT3b","Nx","Mx","GS 4+5",27.46,192,351]
["DV520","Prostate","T",{"v":63.3,"d":"63"},"M","Tr","adenokarcinom","pT2c","N1","Mx","GS3+4",31.56,197,355]
["DV521","Prostate","T",{"v":67.6,"d":"68"},"M","Tr","adenokarcinom","pT3a","N1","Mx","GS 4+3",28.73,204,359]
["DV523","Prostate","T",{"v":60.9,"d":"61"},"M","Tr","adenokarcinom","pT3b","N0","M0","GS4+5",32.56,214,366]
["DV524","Prostate","T",66,"M","Tr","adenokarcinom","pT2a","N0","M0","GS3+4",29.07,218,369]
["DV525","Prostate","T",{"v":74.5,"d":"75"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","GS4+3",28.72,224,372]
["DV527","Prostate","T",72,"M","Tr","adenokarcinom","pT2c","Nx","Mx","GS4+3",27.43,232,378]
["DV528","Prostate","T",{"v":65.5,"d":"66"},"M","Tr","adenokarcinom","pT2c","Nx","Mx","GS3+4",29.01,236,381]
["DV462","Prostate","T",{"v":62.6,"d":"63"},"M","Val","adenokarcinom","pT3a","Nx","Mx","G3+4",27.68,479,4]
["DV466","Prostate","T",{"v":46.5,"d":"47"},"M","Val","adenokarcinom","pT3a","N0","Mx","G4+3",31.8,513,36]
["DV470","Prostate","T",{"v":70.3,"d":"70"},"M","Val","acinar adenocarcinoma","pT2c","Nx","Mx","G3+4",31.22,549,68]
["DV474","Prostate","T",{"v":65.4,"d":"65"},"M","Val","adenokarcinom","pT2c","Nx","Mx","G4+3",26.23,582,100]
["DV478","Prostate","T",{"v":52.4,"d":"52"},"M","Val","adenokarcinom","pT2c","Nx","Mx","G3+4",27.97,452,132]
["DV482","Prostate","T",{"v":51.9,"d":"52"},"M","Val","adenokarcinom","pT2c","N0","Mx","G3+4",27.17,394,164]
["DV486","Prostate","T",{"v":59.7,"d":"60"},"M","Val","adenokarcinom","pT2c","N0","Mx","G3+4",25.28,423,196]
["DV490","Prostate","T",{"v":68.8,"d":"69"},"M","Val","adenokarcinom","pT3a","Nx","Mx","G3+4",26.79,22,220]
["DV494","Prostate","T",{"v":71.1,"d":"71"},"M","Val","adenokarcinom","pT2c","Nx","Mx","G3+4",31.64,50,244]
["DV498","Prostate","T",{"v":64.7,"d":"65"},"M","Val","adenokarcinom","pT2c","Nx","Mx","G2+3",24.91,76,265]
["DV502","Prostate","T",{"v":72.5,"d":"73"},"M","Val","acinar adenocarcinoma","pTx","Nx","Mx","G3+3",25.88,99,283]
["DV506","Prostate","T",{"v":65.8,"d":"66"},"M","Val","adenokarcinom","pT2","N0","M0","GS4+5",30.07,121,299]
["DV510","Prostate","T",{"v":63.7,"d":"64"},"M","Val","adenokarcinom","pT2a","Nx","M0","GS 3+3",30.93,143,315]
["DV514","Prostate","T",{"v":70.1,"d":"70"},"M","Val","adenokarcinom","pT2c","N0","M0","GS3+4",23.3,165,331]
["DV518","Prostate","T",{"v":72.6,"d":"73"},"M","Val","adenokarcinom","pT2c","Nx","Mx","GS3+4",23.89,187,347]
["DV522","Prostate","T",{"v":67.4,"d":"67"},"M","Val","adenokarcinom","pT2b","Nx","Mx","GS3+4",29.74,209,363]
["DV526","Prostate","T",{"v":69.3,"d":"69"},"M","Val","adenokarcinom","pT2c","Nx","Mx","GS 3+4",27.16,228,375]
[]
["BMI - Body mass index"]
["N - Normal"]
["T - Tumor"]
["Val - Validation"]
["Tr - Training"]
["F - Female"]
["M - Male"]
["x - cannot be measured"]
[" -  not assigned or not applicable"]

{"sheet":"Table 3a,b","index":2,"n_rows":601,"n_cols":145,"rows_kept":601,"merged":[[546,3,546,4],[547,3,549,4],[550,3,552,4],[553,3,555,4],[556,3,556,4],[557,3,559,4],[560,3,562,4],[563,3,565,4],[566,3,566,4],[567,3,569,4],[570,3,572,4],[573,3,573,4],[574,3,576,4],[577,3,579,4],[580,3,580,4],[581,3,583,4],[584,3,586,4],[587,3,589,4],[590,3,592,4],[593,3,593,4],[594,3,596,4],[597,3,599,4],[600,3,600,4]]}
["Supplementary Table 3a. Molar concentrations of individual lipids measured in Phase I (discovery) by UHPSFC/MS."]
[]
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[]
["Supplementary Table 3b. The statistical evaluation of Phase I (discovery) measured by UHPSFC/MS. "]
[]
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cancer)",null,"Males",{"$f":"((G560-G567)/(SQRT(((G587^2)/G550)+((G594^2)/G557))))","v":{"v":5.376332847943386,"d":"5.38"}},{"$f":"((H560-H567)/(SQRT(((H587^2)/H550)+((H594^2)/H557))))","v":{"v":7.909725671944134,"d":"7.91"}},{"v":6.952374612809683,"d":"6.95"},{"v":9.050729587414832,"d":"9.05"},{"v":8.538466523251088,"d":"8.54"},{"v":5.887621264017555,"d":"5.89"},{"v":8.12502191370746,"d":"8.13"},{"v":7.451361783583653,"d":"7.45"},{"v":7.351131187720569,"d":"7.35"},{"v":1.1628567990040557,"d":"1.16"},{"v":2.0220883589731184,"d":"2.02"},{"v":1.8475522811102023,"d":"1.85"},{"v":1.3194516243233783,"d":"1.32"},{"v":0.9495756009095795,"d":"0.95"},{"v":0.28428441573258545,"d":"0.28"},{"v":2.437486707304876,"d":"2.44"},{"v":3.062745753820608,"d":"3.06"},{"v":2.915981077330095,"d":"2.92"},{"v":2.1731562972665737,"d":"2.17"},{"v":2.4815215601325376,"d":"2.48"},{"v":2.5430430087779414,"d":"2.54"},{"v":2.467055534786417,"d":"2.47"},{"v":2.0532453948610385,"d":"2.05"},{"v":3.240003773680817,"d":"3.24"},{"v":3.8768787728860397,"d":"3.88"},{"v":3.601154629926193,"d":"3.60"},{"v":3.3089295986396525,"d":"3.31"},{"v":2.292775322744023,"d":"2.29"},{"v":3.5742748209772084,"d":"3.57"},{"v":3.0805192397417196,"d":"3.08"},{"v":3.1115266523236302,"d":"3.11"},{"v":3.4472875342196585,"d":"3.45"},{"v":3.359009430716213,"d":"3.36"},{"v":2.2214272133795747,"d":"2.22"},{"v":1.6814283572535649,"d":"1.68"},{"v":2.362851313380071,"d":"2.36"},{"v":3.278321194004345,"d":"3.28"},{"v":3.6283099663301805,"d":"3.63"},{"v":4.281455891501561,"d":"4.28"},{"v":3.9952533495221236,"d":"4.00"},{"v":2.7407462828935776,"d":"2.74"},{"v":2.698231638132906,"d":"2.70"},{"v":3.0089248657678387,"d":"3.01"},{"v":3.271126874562621,"d":"3.27"},{"v":2.5729012920987038,"d":"2.57"},{"v":1.291781797723663,"d":"1.29"},{"v":2.283480427233438,"d":"2.28"},{"v":2.657028029075373,"d":"2.66"},{"v":2.86261345821364,"d":"2.86"},{"v":3.201786041378311,"d":"3.20"},{"v":2.9054364274666193,"d":"2.91"},{"v":2.763050184698208,"d":"2.76"},{"v":1.83112639613507,"d":"1.83"},{"v":2.122425454590588,"d":"2.12"},{"v":2.23024853995834,"d":"2.23"},{"v":2.0040270844151977,"d":"2.00"},{"v":1.6578242761196036,"d":"1.66"},{"v":1.2832509797454856,"d":"1.28"},{"v":2.4502200349323005,"d":"2.45"},{"v":2.7052332760035402,"d":"2.71"},{"v":3.128586211366859,"d":"3.13"},{"v":2.927064615419091,"d":"2.93"},{"v":2.071008108809842,"d":"2.07"},{"v":1.4803520264839225,"d":"1.48"},{"v":1.2918136739010149,"d":"1.29"},{"$f":"((BT560-BT567)/(SQRT(((BT587^2)/BT550)+((BT594^2)/BT557))))","v":{"v":1.7117672785241733,"d":"1.71"}},{"v":1.783317270498876,"d":"1.78"},{"v":1.6802032178149522,"d":"1.68"},{"v":1.5528315783306565,"d":"1.55"},{"v":1.3115637818627597,"d":"1.31"},{"v":1.9537807037550545,"d":"1.95"},{"v":0.2427067834293508,"d":"0.24"},{"v":2.9646639126586014,"d":"2.96"},{"v":-0.07682264811198235,"d":"-0.08"},{"v":1.1888172621012092,"d":"1.19"},{"v":0.18030920012219967,"d":"0.18"},{"v":4.7843157102784275,"d":"4.78"},{"v":2.7306143601767423,"d":"2.73"},{"v":2.8736405807988405,"d":"2.87"},{"v":5.6318522741651265,"d":"5.63"},{"v":5.47181983398123,"d":"5.47"},{"v":5.0840210735383,"d":"5.08"},{"v":6.366109133576325,"d":"6.37"},{"v":5.563836718606694,"d":"5.56"},{"v":5.334394181811819,"d":"5.33"},{"v":3.507439205936116,"d":"3.51"},{"v":3.4758447242638977,"d":"3.48"},{"v":5.183007769920151,"d":"5.18"},{"v":2.9236182489688933,"d":"2.92"},{"v":5.3842548118634594,"d":"5.38"},{"v":4.736995506631564,"d":"4.74"},{"v":5.910767341712152,"d":"5.91"},{"v":3.9288384084142316,"d":"3.93"},{"v":8.820573730367279,"d":"8.82"},{"v":5.548867040244534,"d":"5.55"},{"v":4.038226410512426,"d":"4.04"},{"v":6.479778230675785,"d":"6.48"},{"v":5.16796048186101,"d":"5.17"},{"v":5.585317408572843,"d":"5.59"},{"v":2.844101800788503,"d":"2.84"},{"v":3.164538949681594,"d":"3.16"},{"v":6.468341587122513,"d":"6.47"},{"v":7.974039996407483,"d":"7.97"},{"v":8.102317373156401,"d":"8.10"},{"v":2.9717563882726106,"d":"2.97"},{"v":4.191476173458619,"d":"4.19"},{"v":5.169240813791305,"d":"5.17"},{"v":4.484360510352812,"d":"4.48"},{"v":2.6269321799505874,"d":"2.63"},{"v":4.192758292631678,"d":"4.19"},{"v":5.079189997975925,"d":"5.08"},{"v":6.263472492134789,"d":"6.26"},{"v":4.987851065994211,"d":"4.99"},{"v":2.977141794922493,"d":"2.98"},{"v":3.192513066938728,"d":"3.19"},{"v":4.711581470430697,"d":"4.71"},{"v":3.6597754359805856,"d":"3.66"},{"v":3.0913310730145027,"d":"3.09"},{"v":-0.5327527903140779,"d":"-0.53"},{"v":6.782295030442992,"d":"6.78"},{"v":4.0658286194267514,"d":"4.07"},{"v":7.19124621811689,"d":"7.19"},{"v":8.702843365195053,"d":"8.70"},{"v":5.355795229934077,"d":"5.36"},{"v":5.787769567503484,"d":"5.79"},{"v":3.9911826503971284,"d":"3.99"},{"v":7.558848771372903,"d":"7.56"},{"v":4.912706408858016,"d":"4.91"},{"v":7.782086113242273,"d":"7.78"},{"$f":"((EF560-EF567)/(SQRT(((EF587^2)/EF550)+((EF594^2)/EF557))))","v":{"v":8.69656073595229,"d":"8.70"}},{"v":8.156690880158285,"d":"8.16"},{"v":8.844458119272073,"d":"8.84"},{"v":7.000218702122259,"d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{"sheet":"Table 4a-i","index":3,"n_rows":193,"n_cols":16,"rows_kept":193,"merged":[[3,0,4,0],[3,1,4,1],[3,3,3,4],[3,5,4,5],[3,6,4,6],[3,8,3,9],[3,10,4,10],[3,11,4,11],[3,13,3,14],[3,15,4,15],[5,0,16,0],[17,0,28,0],[32,0,33,0],[32,1,33,1],[32,3,32,4],[32,5,33,5],[32,6,33,6],[32,8,32,9],[32,10,33,10],[32,11,33,11],[32,13,32,14],[32,15,33,15],[34,0,45,0],[46,0,57,0],[61,0,62,0],[61,1,62,1],[61,3,61,4],[61,5,62,5],[61,6,62,6],[61,8,61,9],[61,10,62,10],[61,11,62,11],[61,13,61,14],[61,15,62,15],[63,0,74,0],[75,0,86,0],[90,0,91,0],[90,1,91,1],[90,3,90,4],[90,5,91,5],[90,6,91,6],[90,8,90,9],[90,10,91,10],[90,11,91,11],[90,13,90,14],[90,15,91,15],[92,0,103,0],[104,0,115,0],[119,0,120,0],[119,1,120,1],[119,2,120,2],[119,3,120,3],[119,4,120,4],[119,5,120,5],[119,6,120,6],[121,0,132,0],[137,0,137,5],[138,1,138,2],[139,0,141,0],[139,1,139,2],[140,1,141,2],[142,0,144,0],[142,1,142,2],[143,1,144,2],[145,0,147,0],[145,1,145,2],[146,1,147,2],[152,0,152,5],[153,1,153,2],[154,0,156,0],[154,1,154,2],[155,1,156,2],[157,0,159,0],[157,1,157,2],[158,1,159,2],[160,0,162,0],[160,1,160,2],[161,1,162,2],[167,0,167,5],[168,1,168,2],[169,0,171,0],[169,1,169,2],[170,1,171,2],[172,0,174,0],[172,1,172,2],[173,1,174,2],[175,0,177,0],[175,1,175,2],[176,1,177,2],[182,0,182,5],[183,1,183,2],[184,0,186,0],[184,1,184,2],[185,1,186,2],[187,0,189,0],[187,1,187,2],[188,1,189,2],[190,0,192,0],[190,1,190,2],[191,1,192,2]]}
["Supplementary Table 4. Characteristics of OPLS-DA models for all MS based methods, phases and cancer types: "]
["a, Sensitivity, specificity, and accuracy values for training and validation sets. All variables used passing the criteria for inclusion (138 variables UHPSFC/MS and 412 variables for shotgun MS)."]
[]
[null,"Kidney","Phase I (discovery)","Phase II (qualification)",null,"Average all data sets","Breast","Phase I (discovery)","Phase II (qualification)",null,"Average all data sets","Prostate","Phase I (discovery)","Phase II (qualification)",null,"Average all data sets"]
[null,null,"UHPSFC/MS","UHPSFC/MS","Shotgun MS (LR)",null,null,"UHPSFC/MS","UHPSFC/MS","Shotgun MS (LR)",null,null,"UHPSFC/MS","UHPSFC/MS","Shotgun MS (LR)"]
["Training set","Specificity",{"$nulls":4},"Specificity",{"$nulls":4},"Specificity"]
[null,"Male ",{"v":81.66666666666667,"d":"81.7"},{"v":93.33333333333333,"d":"93.3"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(C7:E7)","v":{"v":91.66666666666667,"d":"91.7"}},"Male ",{"v":100,"d":"100.0"},{"v":100,"d":"100.0"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(H7:J7)","v":{"v":100,"d":"100.0"}},"Male ",{"v":90,"d":"90.0"},{"v":98.33333333333333,"d":"98.3"},{"v":96.66666666666667,"d":"96.7"},{"$f":"AVERAGE(M7:O7)","v":{"v":95,"d":"95.0"}}]
[null,"Female",{"v":98.66666666666667,"d":"98.7"},{"v":98.66666666666667,"d":"98.7"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(C8:E8)","v":{"v":99.11111111111113,"d":"99.1"}},"Female",{"v":93.33333333333333,"d":"93.3"},{"v":98.66666666666667,"d":"98.7"},{"v":89.33333333333333,"d":"89.3"},{"$f":"AVERAGE(H8:J8)","v":{"v":93.77777777777777,"d":"93.8"}}]
[null,"Average",{"$f":"AVERAGE(C7:C8)","v":{"v":90.16666666666667,"d":"90.2"}},{"$f":"AVERAGE(D7:D8)","v":{"v":96,"d":"96.0"}},{"$f":"AVERAGE(E7:E8)","v":{"v":100,"d":"100.0"}},{"v":95.3888888888889,"d":"95.4"},"Average",{"$f":"AVERAGE(H7:H8)","v":{"v":96.66666666666666,"d":"96.7"}},{"$f":"AVERAGE(I7:I8)","v":{"v":99.33333333333334,"d":"99.3"}},{"$f":"AVERAGE(J7:J8)","v":{"v":94.66666666666666,"d":"94.7"}},{"v":96.88888888888887,"d":"96.9"}]
[null,"Sensitivity",{"$nulls":4},"Sensitivity",{"$nulls":4},"Sensitivity"]
[null,"Male ",{"v":84.21052631578948,"d":"84.2"},{"v":85.96491228070175,"d":"86.0"},{"v":92.98245614035088,"d":"93.0"},{"$f":"AVERAGE(C11:E11)","v":{"v":87.71929824561403,"d":"87.7"}},"Male ",{"v":100,"d":"100.0"},{"v":100,"d":"100.0"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(H11:J11)","v":{"v":100,"d":"100.0"}},"Male ",{"v":82,"d":"82.0"},{"v":82,"d":"82.0"},{"v":98,"d":"98.0"},{"$f":"AVERAGE(M11:O11)","v":{"v":87.33333333333333,"d":"87.3"}}]
[null,"Female",{"v":76,"d":"76.0"},{"v":72,"d":"72.0"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(C12:E12)","v":{"v":82.66666666666667,"d":"82.7"}},"Female",{"v":80,"d":"80.0"},{"v":85.71428571428571,"d":"85.7"},{"v":77.14285714285714,"d":"77.1"},{"$f":"AVERAGE(H12:J12)","v":{"v":80.95238095238095,"d":"81.0"}}]
[null,"Average",{"$f":"AVERAGE(C11:C12)","v":{"v":80.10526315789474,"d":"80.1"}},{"$f":"AVERAGE(D11:D12)","v":{"v":78.98245614035088,"d":"79.0"}},{"$f":"AVERAGE(E11:E12)","v":{"v":96.49122807017544,"d":"96.5"}},{"v":85.19298245614034,"d":"85.2"},"Average",{"$f":"AVERAGE(H11:H12)","v":{"v":90,"d":"90.0"}},{"$f":"AVERAGE(I11:I12)","v":{"v":92.85714285714286,"d":"92.9"}},{"$f":"AVERAGE(J11:J12)","v":{"v":88.57142857142857,"d":"88.6"}},{"v":90.47619047619048,"d":"90.5"}]
[null,"Accuracy",{"$nulls":4},"Accuracy",{"$nulls":4},"Accuracy"]
[null,"Male ",{"v":82.90598290598291,"d":"82.9"},{"v":89.74358974358974,"d":"89.7"},{"v":95,"d":"95.0"},{"$f":"AVERAGE(C15:E15)","v":{"v":89.2165242165242,"d":"89.2"}},"Male ",{"v":100,"d":"100.0"},{"v":100,"d":"100.0"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(H15:J15)","v":{"v":100,"d":"100.0"}},"Male ",{"v":86.36363636363636,"d":"86.4"},{"v":90.9090909090909,"d":"90.9"},{"v":97.27272727272727,"d":"97.3"},{"$f":"AVERAGE(M15:O15)","v":{"v":91.5151515151515,"d":"91.5"}}]
[null,"Female",{"v":93,"d":"93.0"},{"v":92,"d":"92.0"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(C16:E16)","v":{"v":95,"d":"95.0"}},"Female",{"v":86.89655172413794,"d":"86.9"},{"v":92.41379310344827,"d":"92.4"},{"v":83.44827586206897,"d":"83.4"},{"$f":"AVERAGE(H16:J16)","v":{"v":87.58620689655173,"d":"87.6"}}]
[null,"Average",{"$f":"AVERAGE(C15:C16)","v":{"v":87.95299145299145,"d":"88.0"}},{"$f":"AVERAGE(D15:D16)","v":{"v":90.87179487179486,"d":"90.9"}},{"$f":"AVERAGE(E15:E16)","v":97.5},{"$f":"AVERAGE(C17:E17)","v":{"v":92.10826210826211,"d":"92.1"}},"Average",{"$f":"AVERAGE(H15:H16)","v":{"v":93.44827586206897,"d":"93.4"}},{"$f":"AVERAGE(I15:I16)","v":{"v":96.20689655172413,"d":"96.2"}},{"$f":"AVERAGE(J15:J16)","v":{"v":91.72413793103448,"d":"91.7"}},{"v":93.79310344827586,"d":"93.8"}]
["Validation set","Specificity",{"$nulls":4},"Specificity",{"$nulls":4},"Specificity"]
[null,"Male ",{"v":90.625,"d":"90.6"},87.5,{"v":100,"d":"100.0"},{"$f":"AVERAGE(C19:E19)","v":{"v":92.70833333333333,"d":"92.7"}},"Male ",{"v":100,"d":"100.0"},{"v":100,"d":"100.0"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(H19:J19)","v":{"v":100,"d":"100.0"}},"Male ",{"v":90,"d":"90.0"},{"v":85,"d":"85.0"},{"v":65,"d":"65.0"},{"$f":"AVERAGE(M19:O19)","v":{"v":80,"d":"80.0"}}]
[null,"Female",{"v":88,"d":"88.0"},{"v":100,"d":"100.0"},{"v":85.71428571428571,"d":"85.7"},{"$f":"AVERAGE(C20:E20)","v":{"v":91.23809523809524,"d":"91.2"}},"Female",{"v":88,"d":"88.0"},{"v":84,"d":"84.0"},{"v":80,"d":"80.0"},{"$f":"AVERAGE(H20:J20)","v":{"v":84,"d":"84.0"}}]
[null,"Average",{"$f":"AVERAGE(C19:C20)","v":{"v":89.3125,"d":"89.3"}},{"$f":"AVERAGE(D19:D20)","v":{"v":93.75,"d":"93.8"}},{"$f":"AVERAGE(E19:E20)","v":{"v":92.85714285714286,"d":"92.9"}},{"v":91.97321428571429,"d":"92.0"},"Average",{"$f":"AVERAGE(H19:H20)","v":{"v":94,"d":"94.0"}},{"$f":"AVERAGE(I19:I20)","v":{"v":92,"d":"92.0"}},{"$f":"AVERAGE(J19:J20)","v":{"v":90,"d":"90.0"}},{"v":92,"d":"92.0"}]
[null,"Sensitivity",{"$nulls":4},"Sensitivity",{"$nulls":4},"Sensitivity"]
[null,"Male ",{"v":73.33333333333333,"d":"73.3"},{"v":70,"d":"70.0"},{"v":90,"d":"90.0"},{"$f":"AVERAGE(C23:E23)","v":{"v":77.77777777777777,"d":"77.8"}},"Male ",{"v":100,"d":"100.0"},{"v":50,"d":"50.0"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(H23:J23)","v":{"v":83.33333333333333,"d":"83.3"}},"Male ",{"v":82.3529411764706,"d":"82.4"},{"v":76.47058823529412,"d":"76.5"},{"v":76.47058823529412,"d":"76.5"},{"$f":"AVERAGE(M23:O23)","v":{"v":78.4313725490196,"d":"78.4"}}]
[null,"Female",{"v":71.42857142857143,"d":"71.4"},{"v":85.71428571428571,"d":"85.7"},{"v":85.71428571428571,"d":"85.7"},{"$f":"AVERAGE(C24:E24)","v":{"v":80.95238095238095,"d":"81.0"}},"Female",62.5,{"v":66.66666666666667,"d":"66.7"},{"v":75,"d":"75.0"},{"$f":"AVERAGE(H24:J24)","v":{"v":68.05555555555556,"d":"68.1"}}]
[null,"Average",{"$f":"AVERAGE(C23:C24)","v":{"v":72.38095238095238,"d":"72.4"}},{"$f":"AVERAGE(D23:D24)","v":{"v":77.85714285714286,"d":"77.9"}},{"$f":"AVERAGE(E23:E24)","v":{"v":87.85714285714286,"d":"87.9"}},{"v":79.36507936507937,"d":"79.4"},"Average",{"$f":"AVERAGE(H23:H24)","v":{"v":81.25,"d":"81.3"}},{"$f":"AVERAGE(I23:I24)","v":{"v":58.333333333333336,"d":"58.3"}},{"$f":"AVERAGE(J23:J24)","v":87.5},{"v":75.69444444444444,"d":"75.7"}]
[null,"Accuracy",{"$nulls":4},"Accuracy",{"$nulls":4},"Accuracy"]
[null,"Male ",{"v":82.25806451612904,"d":"82.3"},{"v":79.03225806451613,"d":"79.0"},{"v":92.5925925925926,"d":"92.6"},{"$f":"AVERAGE(C27:E27)","v":{"v":84.62763839107926,"d":"84.6"}},"Male ",{"v":100,"d":"100.0"},{"v":95.45454545454545,"d":"95.5"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(H27:J27)","v":{"v":98.48484848484848,"d":"98.5"}},"Male ",{"v":86.48648648648648,"d":"86.5"},{"v":81.08108108108108,"d":"81.1"},{"v":70.27027027027027,"d":"70.3"},{"$f":"AVERAGE(M27:O27)","v":{"v":79.27927927927927,"d":"79.3"}}]
[null,"Female",{"v":84.375,"d":"84.4"},{"v":96.875,"d":"96.9"},{"v":85.71428571428571,"d":"85.7"},{"$f":"AVERAGE(C28:E28)","v":{"v":88.98809523809524,"d":"89.0"}},"Female",{"v":75.51020408163265,"d":"75.5"},{"v":75.51020408163265,"d":"75.5"},{"v":77.55102040816327,"d":"77.6"},{"$f":"AVERAGE(H28:J28)","v":{"v":76.19047619047619,"d":"76.2"}}]
[null,"Average",{"$f":"AVERAGE(C27:C28)","v":{"v":83.31653225806451,"d":"83.3"}},{"$f":"AVERAGE(D27:D28)","v":{"v":87.95362903225806,"d":"88.0"}},{"$f":"AVERAGE(E27:E28)","v":{"v":89.15343915343915,"d":"89.2"}},{"v":86.80786681458723,"d":"86.8"},"Average",{"$f":"AVERAGE(H27:H28)","v":{"v":87.75510204081633,"d":"87.8"}},{"$f":"AVERAGE(I27:I28)","v":{"v":85.48237476808904,"d":"85.5"}},{"$f":"AVERAGE(J27:J28)","v":{"v":88.77551020408163,"d":"88.8"}},{"$f":"AVERAGE(H29:J29)","v":{"v":87.33766233766232,"d":"87.3"}}]
[]
["b, Sensitivity, specificity, and accuracy values for training and validation sets. Common variables for all 3 data sets are used (91 variables)."]
[]
[null,"Kidney","Phase I (discovery)","Phase II (qualification)",null,"Average all data sets","Breast","Phase I (discovery)","Phase II (qualification)",null,"Average all data sets","Prostate","Phase I (discovery)","Phase II (qualification)",null,"Average all data sets"]
[null,null,"UHPSFC/MS","UHPSFC/MS","Shotgun MS (LR)",null,null,"UHPSFC/MS","UHPSFC/MS","Shotgun MS (LR)",null,null,"UHPSFC/MS","UHPSFC/MS","Shotgun MS (LR)"]
["Training set","Specificity",{"$nulls":4},"Specificity",{"$nulls":4},"Specificity"]
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[]
["c, Sensitivity, specificity, and accuracy values for training and validation sets. Only variables included, which are significant according to the Bonferroni correction in >10 from 15 models (considering all cancer types and data sets-29 variables). SM 38:1 and SM 42:1 were excluded as those variables were only significant for UHPSFC/MS data sets (10/10) and therefore a method bias can not be excluded. "]
[]
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[null,"Female",{"v":84.375,"d":"84.4"},{"v":81.25,"d":"81.3"},{"v":64.28571428571429,"d":"64.3"},{"$f":"AVERAGE(C86:E86)","v":{"v":76.63690476190476,"d":"76.6"}},"Female",{"v":77.55102040816327,"d":"77.6"},{"v":81.63265306122449,"d":"81.6"},{"v":77.55102040816327,"d":"77.6"},{"$f":"AVERAGE(H86:J86)","v":{"v":78.91156462585035,"d":"78.9"}}]
[null,"Average",{"$f":"AVERAGE(C85:C86)","v":{"v":78.47782258064515,"d":"78.5"}},{"$f":"AVERAGE(D85:D86)","v":{"v":80.14112903225806,"d":"80.1"}},{"$f":"AVERAGE(E85:E86)","v":{"v":72.88359788359789,"d":"72.9"}},{"v":77.1675164988337,"d":"77.2"},"Average",{"$f":"AVERAGE(H85:H86)","v":{"v":86.50278293135436,"d":"86.5"}},{"$f":"AVERAGE(I85:I86)","v":{"v":88.54359925788498,"d":"88.5"}},{"$f":"AVERAGE(J85:J86)","v":{"v":86.50278293135436,"d":"86.5"}},{"$f":"AVERAGE(H87:J87)","v":{"v":87.18305504019791,"d":"87.2"}}]
[]
["d, Sensitivity, specificity, and accuracy values for training and validation sets. Only variables included, which are significant according to the Bonferroni correction in >14 from 15 models (considering all cancer types and data sets-7 variables)."]
[]
[null,"Kidney","Phase I (discovery)","Phase II (qualification)",null,"Average all data sets","Breast","Phase I (discovery)","Phase II (qualification)",null,"Average all data sets","Prostate","Phase I (discovery)","Phase II (qualification)",null,"Average all data sets"]
[null,null,"UHPSFC/MS","UHPSFC/MS","Shotgun MS (LR)",null,null,"UHPSFC/MS","UHPSFC/MS","Shotgun MS (LR)",null,null,"UHPSFC/MS","UHPSFC/MS","Shotgun MS (LR)"]
["Training set","Specificity",{"$nulls":4},"Specificity",{"$nulls":4},"Specificity"]
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[null,"Female",{"v":100,"d":"100.0"},{"v":98.66666666666667,"d":"98.7"},87.5,{"$f":"AVERAGE(C95:E95)","v":{"v":95.3888888888889,"d":"95.4"}},"Female",{"v":90.66666666666667,"d":"90.7"},{"v":90.66666666666667,"d":"90.7"},{"v":85.33333333333333,"d":"85.3"},{"$f":"AVERAGE(H95:J95)","v":{"v":88.8888888888889,"d":"88.9"}}]
[null,"Average",{"$f":"AVERAGE(C94:C95)","v":97.5},{"$f":"AVERAGE(D94:D95)","v":{"v":97.66666666666667,"d":"97.7"}},{"$f":"AVERAGE(E94:E95)","v":{"v":67.66304347826087,"d":"67.7"}},{"$f":"AVERAGE(C96:E96)","v":{"v":87.60990338164252,"d":"87.6"}},"Average",{"$f":"AVERAGE(H94:H95)","v":{"v":95.33333333333334,"d":"95.3"}},{"$f":"AVERAGE(I94:I95)","v":{"v":95.33333333333334,"d":"95.3"}},{"$f":"AVERAGE(J94:J95)","v":{"v":92.66666666666666,"d":"92.7"}},{"$f":"AVERAGE(H96:J96)","v":{"v":94.44444444444446,"d":"94.4"}}]
[null,"Sensitivity",{"$nulls":4},"Sensitivity",{"$nulls":4},"Sensitivity"]
[null,"Male ",{"v":73.6842105263158,"d":"73.7"},{"v":70.17543859649123,"d":"70.2"},{"v":89.28571428571429,"d":"89.3"},{"$f":"AVERAGE(C98:E98)","v":{"v":77.71512113617376,"d":"77.7"}},"Male ",{"v":71.42857142857143,"d":"71.4"},{"v":85.71428571428571,"d":"85.7"},{"v":71.42857142857143,"d":"71.4"},{"$f":"AVERAGE(H98:J98)","v":{"v":76.19047619047619,"d":"76.2"}},"Male ",{"v":72,"d":"72.0"},{"v":64,"d":"64.0"},{"v":70,"d":"70.0"},{"$f":"AVERAGE(M98:O98)","v":{"v":68.66666666666667,"d":"68.7"}}]
[null,"Female",{"v":36,"d":"36.0"},{"v":36,"d":"36.0"},{"v":72,"d":"72.0"},{"$f":"AVERAGE(C99:E99)","v":{"v":48,"d":"48.0"}},"Female",{"v":62.857142857142854,"d":"62.9"},{"v":65.71428571428571,"d":"65.7"},{"v":67.14285714285714,"d":"67.1"},{"$f":"AVERAGE(H99:J99)","v":{"v":65.23809523809523,"d":"65.2"}}]
[null,"Average",{"$f":"AVERAGE(C98:C99)","v":{"v":54.8421052631579,"d":"54.8"}},{"$f":"AVERAGE(D98:D99)","v":{"v":53.08771929824562,"d":"53.1"}},{"$f":"AVERAGE(E98:E99)","v":{"v":80.64285714285714,"d":"80.6"}},{"$f":"AVERAGE(C100:E100)","v":{"v":62.85756056808688,"d":"62.9"}},"Average",{"$f":"AVERAGE(H98:H99)","v":{"v":67.14285714285714,"d":"67.1"}},{"$f":"AVERAGE(I98:I99)","v":{"v":75.71428571428571,"d":"75.7"}},{"$f":"AVERAGE(J98:J99)","v":{"v":69.28571428571428,"d":"69.3"}},{"$f":"AVERAGE(H100:J100)","v":{"v":70.71428571428571,"d":"70.7"}}]
[null,"Accuracy",{"$nulls":4},"Accuracy",{"$nulls":4},"Accuracy"]
[null,"Male ",{"v":84.61538461538461,"d":"84.6"},{"v":83.76068376068376,"d":"83.8"},{"v":77.21518987341773,"d":"77.2"},{"$f":"AVERAGE(C102:E102)","v":{"v":81.86375274982869,"d":"81.9"}},"Male ",{"v":97.01492537313433,"d":"97.0"},{"v":98.50746268656717,"d":"98.5"},{"v":97.01492537313433,"d":"97.0"},{"$f":"AVERAGE(H102:J102)","v":{"v":97.51243781094529,"d":"97.5"}},"Male ",{"v":83.63636363636364,"d":"83.6"},{"v":81.81818181818181,"d":"81.8"},{"v":82.72727272727273,"d":"82.7"},{"$f":"AVERAGE(M102:O102)","v":{"v":82.72727272727273,"d":"82.7"}}]
[null,"Female",{"v":84,"d":"84.0"},{"v":83,"d":"83.0"},{"v":79.59183673469387,"d":"79.6"},{"$f":"AVERAGE(C103:E103)","v":{"v":82.19727891156462,"d":"82.2"}},"Female",{"v":77.24137931034483,"d":"77.2"},{"v":78.62068965517241,"d":"78.6"},{"v":76.55172413793103,"d":"76.6"},{"$f":"AVERAGE(H103:J103)","v":{"v":77.47126436781609,"d":"77.5"}}]
[null,"Average",{"$f":"AVERAGE(C102:C103)","v":{"v":84.3076923076923,"d":"84.3"}},{"$f":"AVERAGE(D102:D103)","v":{"v":83.38034188034189,"d":"83.4"}},{"$f":"AVERAGE(E102:E103)","v":{"v":78.40351330405579,"d":"78.4"}},{"$f":"AVERAGE(C104:E104)","v":{"v":82.03051583069666,"d":"82.0"}},"Average",{"$f":"AVERAGE(H102:H103)","v":{"v":87.12815234173958,"d":"87.1"}},{"$f":"AVERAGE(I102:I103)","v":{"v":88.56407617086978,"d":"88.6"}},{"$f":"AVERAGE(J102:J103)","v":{"v":86.78332475553267,"d":"86.8"}},{"$f":"AVERAGE(H104:J104)","v":{"v":87.49185108938066,"d":"87.5"}}]
["Validation set","Specificity",{"$nulls":4},"Specificity",{"$nulls":4},"Specificity"]
[null,"Male ",{"v":84.375,"d":"84.4"},{"v":96.875,"d":"96.9"},{"v":57.142857142857146,"d":"57.1"},{"$f":"AVERAGE(C106:E106)","v":{"v":79.46428571428571,"d":"79.5"}},"Male ",{"v":95,"d":"95.0"},{"v":100,"d":"100.0"},{"v":100,"d":"100.0"},{"$f":"AVERAGE(H106:J106)","v":{"v":98.33333333333333,"d":"98.3"}},"Male ",{"v":85,"d":"85.0"},{"v":85,"d":"85.0"},{"v":80,"d":"80.0"},{"$f":"AVERAGE(M106:O106)","v":{"v":83.33333333333333,"d":"83.3"}}]
[null,"Female",{"v":96,"d":"96.0"},{"v":96,"d":"96.0"},{"v":71.42857142857143,"d":"71.4"},{"$f":"AVERAGE(C107:E107)","v":{"v":87.80952380952381,"d":"87.8"}},"Female",{"v":88,"d":"88.0"},{"v":92,"d":"92.0"},{"v":92,"d":"92.0"},{"$f":"AVERAGE(H107:J107)","v":{"v":90.66666666666667,"d":"90.7"}}]
[null,"Average",{"$f":"AVERAGE(C106:C107)","v":{"v":90.1875,"d":"90.2"}},{"$f":"AVERAGE(D106:D107)","v":{"v":96.4375,"d":"96.4"}},{"$f":"AVERAGE(E106:E107)","v":{"v":64.28571428571429,"d":"64.3"}},{"$f":"AVERAGE(C108:E108)","v":{"v":83.63690476190476,"d":"83.6"}},"Average",{"$f":"AVERAGE(H106:H107)","v":91.5},{"$f":"AVERAGE(I106:I107)","v":{"v":96,"d":"96.0"}},{"$f":"AVERAGE(J106:J107)","v":{"v":96,"d":"96.0"}},{"$f":"AVERAGE(H108:J108)","v":94.5}]
[null,"Sensitivity",{"$nulls":4},"Sensitivity",{"$nulls":4},"Sensitivity"]
[null,"Male ",{"v":73.33333333333333,"d":"73.3"},{"v":70,"d":"70.0"},{"v":95,"d":"95.0"},{"$f":"AVERAGE(C110:E110)","v":{"v":79.44444444444444,"d":"79.4"}},"Male ",{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":50,"d":"50.0"},{"$f":"AVERAGE(H110:J110)","v":{"v":16.666666666666668,"d":"16.7"}},"Male ",{"v":70.58823529411765,"d":"70.6"},{"v":70.58823529411765,"d":"70.6"},{"v":64.70588235294117,"d":"64.7"},{"$f":"AVERAGE(M110:O110)","v":{"v":68.62745098039215,"d":"68.6"}}]
[null,"Female",{"v":57.142857142857146,"d":"57.1"},{"v":57.142857142857146,"d":"57.1"},{"v":71.42857142857143,"d":"71.4"},{"$f":"AVERAGE(C111:E111)","v":{"v":61.904761904761905,"d":"61.9"}},"Female",{"v":66.66666666666667,"d":"66.7"},62.5,62.5,{"$f":"AVERAGE(H111:J111)","v":{"v":63.88888888888889,"d":"63.9"}}]
[null,"Average",{"$f":"AVERAGE(C110:C111)","v":{"v":65.23809523809524,"d":"65.2"}},{"$f":"AVERAGE(D110:D111)","v":{"v":63.57142857142857,"d":"63.6"}},{"$f":"AVERAGE(E110:E111)","v":{"v":83.21428571428572,"d":"83.2"}},{"$f":"AVERAGE(C112:E112)","v":{"v":70.67460317460318,"d":"70.7"}},"Average",{"$f":"AVERAGE(H110:H111)","v":{"v":33.333333333333336,"d":"33.3"}},{"$f":"AVERAGE(I110:I111)","v":{"v":31.25,"d":"31.3"}},{"$f":"AVERAGE(J110:J111)","v":{"v":56.25,"d":"56.3"}},{"$f":"AVERAGE(H112:J112)","v":{"v":40.27777777777778,"d":"40.3"}}]
[null,"Accuracy",{"$nulls":4},"Accuracy",{"$nulls":4},"Accuracy"]
[null,"Male ",{"v":79.03225806451613,"d":"79.0"},{"v":83.87096774193549,"d":"83.9"},{"v":85.18518518518519,"d":"85.2"},{"$f":"AVERAGE(C114:E114)","v":{"v":82.69613699721226,"d":"82.7"}},"Male ",{"v":86.36363636363636,"d":"86.4"},{"v":90.9090909090909,"d":"90.9"},{"v":95.45454545454545,"d":"95.5"},{"$f":"AVERAGE(H114:J114)","v":{"v":90.90909090909089,"d":"90.9"}},"Male ",{"v":78.37837837837837,"d":"78.4"},{"v":78.37837837837837,"d":"78.4"},{"v":72.97297297297297,"d":"73.0"},{"$f":"AVERAGE(M114:O114)","v":{"v":76.57657657657657,"d":"76.6"}}]
[null,"Female",87.5,87.5,{"v":71.42857142857143,"d":"71.4"},{"$f":"AVERAGE(C115:E115)","v":{"v":82.14285714285715,"d":"82.1"}},"Female",{"v":77.55102040816327,"d":"77.6"},{"v":77.55102040816327,"d":"77.6"},{"v":77.55102040816327,"d":"77.6"},{"$f":"AVERAGE(H115:J115)","v":{"v":77.55102040816327,"d":"77.6"}}]
[null,"Average",{"$f":"AVERAGE(C114:C115)","v":{"v":83.26612903225806,"d":"83.3"}},{"$f":"AVERAGE(D114:D115)","v":{"v":85.68548387096774,"d":"85.7"}},{"$f":"AVERAGE(E114:E115)","v":{"v":78.3068783068783,"d":"78.3"}},{"$f":"AVERAGE(C116:E116)","v":{"v":82.4194970700347,"d":"82.4"}},"Average",{"$f":"AVERAGE(H114:H115)","v":{"v":81.95732838589981,"d":"82.0"}},{"$f":"AVERAGE(I114:I115)","v":{"v":84.2300556586271,"d":"84.2"}},{"$f":"AVERAGE(J114:J115)","v":{"v":86.50278293135436,"d":"86.5"}},{"$f":"AVERAGE(H116:J116)","v":{"v":84.23005565862708,"d":"84.2"}}]
[]
["e, Sensitivity, specificity, and accuracy values for the UHPSFC/MS measurements from the qualification phase using the MDA models from the discovery phase for prediction."]
[]
["UHPSFC/MS",null,"Kidney",null,"Breast",null,"Prostate"]
[]
["Qualification phase sample set","Specificity",null,"Specificity",null,"Specificity"]
[null,"Male ",{"v":61.95652173913044,"d":"62.0"},"Male ",{"v":100,"d":"100.0"},"Male ",87.5]
[null,"Female",{"v":86,"d":"86.0"},"Female",{"v":94,"d":"94.0"}]
[null,"Average",{"$f":"AVERAGE(C123:C124)","v":{"v":73.97826086956522,"d":"74.0"}},"Average",{"$f":"AVERAGE(E123:E124)","v":{"v":97,"d":"97.0"}}]
[null,"Sensitivity",null,"Sensitivity",null,"Sensitivity"]
[null,"Male ",{"v":90.80459770114942,"d":"90.8"},"Male ",{"v":88.88888888888889,"d":"88.9"},"Male ",{"v":74.6268656716418,"d":"74.6"}]
[null,"Female",{"v":71.875,"d":"71.9"},"Female",{"v":57.4468085106383,"d":"57.4"}]
[null,"Average",{"$f":"AVERAGE(C127:C128)","v":{"v":81.33979885057471,"d":"81.3"}},"Average",{"$f":"AVERAGE(E127:E128)","v":{"v":73.1678486997636,"d":"73.2"}}]
[null,"Accuracy",null,"Accuracy",null,"Accuracy"]
[null,"Male ",{"v":75.97765363128492,"d":"76.0"},"Male ",{"v":98.87640449438203,"d":"98.9"},"Male ",{"v":81.63265306122449,"d":"81.6"}]
[null,"Female",{"v":82.57575757575758,"d":"82.6"},"Female",{"v":76.28865979381443,"d":"76.3"}]
[null,"Average",{"$f":"AVERAGE(C131:C132)","v":{"v":79.27670560352125,"d":"79.3"}},"Average",{"$f":"AVERAGE(E131:E132)","v":{"v":87.58253214409822,"d":"87.6"}}]
[]
[]
["f, Summary of predictive components and orthogonal in X components (Training Set). All variables used passing the criteria for inclusion (138 variables UHPSFC/MS and 412 variables for shotgun-MS)."]
[]
["Predictive + Orthogonal in X components"]
["Cancer type ","Phase",null,"Method","Male ","Female"]
["Kidney","Phase I (discovery)",null,"UHPSFC/MS","1+2+0","1+2+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+4+0","1+2+0"]
[{"$nulls":3},"Shotgun MS (LR)","1+2+0","1+3+0"]
["Breast","Phase I (discovery)",null,"UHPSFC/MS","1+5+0","1+3+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+3+0","1+4+0"]
[{"$nulls":3},"Shotgun MS (LR)","1+3+0","1+1+0"]
["Prostate","Phase I (discovery)",null,"UHPSFC/MS","1+3+0","-"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+4+0","-"]
[{"$nulls":3},"Shotgun MS (LR)","1+3+0","-"]
[]
[]
["g, Summary of predictive components and orthogonal in X components (Training Set). Common variables for all 3 data sets are used (91 variables)."]
[]
["Predictive + Orthogonal in X components"]
["Cancer type ","Phase",null,"Method","Male ","Female"]
["Kidney","Phase I (discovery)",null,"UHPSFC/MS","1+1+0","1+1+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+1+0","1+2+0"]
[{"$nulls":3},"Shotgun MS (LR)","1+2+0","1+2+0"]
["Breast","Phase I (discovery)",null,"UHPSFC/MS","1+4+0","1+3+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+3+0","1+4+0"]
[{"$nulls":3},"Shotgun MS (LR)","1+3+0","1+2+0"]
["Prostate","Phase I (discovery)",null,"UHPSFC/MS","1+5+0","-"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+4+0","-"]
[{"$nulls":3},"Shotgun MS (LR)","1+1+0","-"]
[]
[]
["h, Summary of predictive components and orthogonal in X components (Training Set). Only variables included, which are significant according to the Bonferroni correction in >10 from 15 models (considering all cancer types and data sets-29 variables). SM 38:1 and SM 42:1 were excluded as those variables were only significant for UHPSFC/MS data sets (10/10) and therefore a method bias can not be excluded. "]
[]
["Predictive + Orthogonal in X components"]
["Cancer type ","Phase",null,"Method","Male ","Female"]
["Kidney","Phase I (discovery)",null,"UHPSFC/MS","1+2+0","1+4+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+1+0","1+4+0"]
[{"$nulls":3},"Shotgun MS (LR)","1+1+0","1+1+0"]
["Breast","Phase I (discovery)",null,"UHPSFC/MS","1+2+0","1+1+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+1+0","1+1+0"]
[{"$nulls":3},"Shotgun MS (LR)","1+1+0","1+1+0"]
["Prostate","Phase I (discovery)",null,"UHPSFC/MS","1+3+0","-"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+1+0","-"]
[{"$nulls":3},"Shotgun MS (LR)","1+1+0","-"]
[]
[]
["i, Summary of predictive components and orthogonal in X components (Training Set). Only variables included, which are significant according to the Bonferroni correction in >14 from 15 models (considering all cancer types and data sets-29 variables). Only the first two components were used for OPLS modles. "]
[]
["Predictive + Orthogonal in X components"]
["Cancer type ","Phase",null,"Method","Male ","Female"]
["Kidney","Phase I (discovery)",null,"UHPSFC/MS","1+1+0","1+1+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+1+0","1+1+0"]
[{"$nulls":3},"Shotgun MS (LR)","1+1+0","1+1+0"]
["Breast","Phase I (discovery)",null,"UHPSFC/MS","1+1+0","1+1+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+1+0","1+1+0"]
[{"$nulls":3},"Shotgun MS (LR)","1+1+0","1+1+0"]
["Prostate","Phase I (discovery)",null,"UHPSFC/MS","1+1+0","-"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","1+1+0","-"]
[{"$nulls":3},"Shotgun MS (LR)","1+1+0","-"]

{"sheet":"Table 5a,b","index":4,"n_rows":230,"n_cols":28,"rows_kept":230,"merged":[[2,0,2,11],[2,12,2,27],[3,0,3,2],[3,3,3,5],[3,6,3,8],[3,9,3,11],[3,12,3,15],[3,16,3,19],[3,20,3,23],[3,24,3,27],[4,0,4,2],[4,3,4,5],[4,6,4,8],[4,9,4,11],[4,12,4,15],[4,16,4,19],[4,20,4,23],[4,24,4,27],[76,0,76,11],[76,12,76,27],[77,0,77,2],[77,3,77,5],[77,6,77,8],[77,9,77,11],[77,12,77,15],[77,16,77,19],[77,20,77,23],[77,24,77,27],[78,0,78,2],[78,3,78,5],[78,6,78,8],[78,9,78,11],[78,12,78,15],[78,16,78,19],[78,20,78,23],[78,24,78,27]]}
["Supplementary Table 5. Predicted response values calculated from OPLS-DA models for all methods and all phases. All variables used passing the criteria for inclusion (138 variables UHPSFC/MS and 412 variables for Shotgun MS). a, Validation sets."]
[]
["Phase I (discovery)",{"$nulls":11},"Phase II (qualification)"]
["Males",null,null,"Males",null,null,"Females",null,null,"Females",null,null,"Males",{"$nulls":3},"Males",{"$nulls":3},"Females",{"$nulls":3},"Females"]
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[]
["*1 Probability scores ≤0.5 predicted as normal (N), and >0.5 predicted as tumor (T). More detailed description of individual regions: >0.75 – very likely T, 0.6-0.75 – likely T, 0.5-0.6 uncertainly T, 0.4-0.5 – uncertainly healthy, 0.25-0.4 – likely healthy, and <0.25 – very likely healthy."]
[]
["b, Training sets. "]
[]
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["Specificity [%]",null,{"v":81.66666666666667,"d":"81.67"},"Specificity [%]",null,{"v":90,"d":"90.00"},"Specificity [%]",null,{"v":98.66666666666667,"d":"98.67"},"Specificity [%]",null,{"v":93.33333333333333,"d":"93.33"},"Specificity [%]",null,{"v":93.33333333333333,"d":"93.33"},{"v":100,"d":"100.00"},"Specificity [%]",null,{"v":98.33333333333333,"d":"98.33"},{"v":96.66666666666667,"d":"96.67"},"Specificity [%]",null,{"v":98.66666666666667,"d":"98.67"},{"v":100,"d":"100.00"},"Specificity [%]",null,{"v":98.66666666666667,"d":"98.67"},{"v":89.33333333333333,"d":"89.33"}]
["Accuracy [%]",null,{"v":82.90598290598291,"d":"82.91"},"Accuracy [%]",null,{"v":86.36363636363636,"d":"86.36"},"Accuracy [%]",null,{"v":93,"d":"93.00"},"Accuracy [%]",null,{"v":86.89655172413794,"d":"86.90"},"Accuracy [%]",null,{"v":89.74358974358974,"d":"89.74"},{"v":95,"d":"95.00"},"Accuracy [%]",null,{"v":90.9090909090909,"d":"90.91"},{"v":97.27272727272727,"d":"97.27"},"Accuracy [%]",null,{"v":92,"d":"92.00"},{"v":100,"d":"100.00"},"Accuracy [%]",null,{"v":92.41379310344827,"d":"92.41"},{"v":83.44827586206897,"d":"83.45"}]
[]
["*1 Probability scores ≤0.5 predicted as normal (N), and >0.5 predicted as tumor (T). More detailed description of individual regions: >0.75 – very likely T, 0.6-0.75 – likely T, 0.5-0.6 uncertainly T, 0.4-0.5 – uncertainly healthy, 0.25-0.4 – likely healthy, and <0.25 – very likely healthy."]

{"sheet":"Table 6a,b","index":5,"n_rows":596,"n_cols":144,"rows_kept":596,"merged":[[541,3,541,4],[542,3,544,4],[545,3,547,4],[548,3,550,4],[551,3,551,4],[552,3,554,4],[555,3,557,4],[558,3,560,4],[561,3,561,4],[562,3,564,4],[565,3,567,4],[568,3,568,4],[569,3,571,4],[572,3,574,4],[575,3,575,4],[576,3,578,4],[579,3,581,4],[582,3,584,4],[585,3,587,4],[588,3,588,4],[589,3,591,4],[592,3,594,4],[595,3,595,4]]}
["Supplementary Table 6.a Molar concentrations of individual lipids measured in Phase II (qualification) by UHPSFC/MS. "]
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[]
["Supplementary Table 6b. The statistical evaluation of Phase II (qualification) measured by UHPSFC/MS. "]
[]
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{"sheet":"Table 6c,d","index":6,"n_rows":609,"n_cols":419,"rows_kept":139,"cut":true,"merged":[[545,4,545,5],[546,4,548,5],[549,4,551,5],[552,4,554,5],[555,4,557,5],[558,4,558,5],[559,4,561,5],[562,4,564,5],[565,4,567,5],[568,4,570,5],[571,4,571,5],[572,4,574,5],[575,4,577,5],[578,4,578,5],[579,4,581,5],[582,4,584,5],[585,4,585,5],[586,4,588,5],[589,4,591,5],[592,4,594,5],[595,4,597,5],[598,4,600,5],[601,4,601,5],[602,4,604,5],[605,4,607,5],[608,4,608,5]],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
["Supplementary Table 6c. Molar concentrations of individual lipids measured in Phase II (qualification) by Shotgun MS. "]
[]
["Sample code","State","Type","Gender","Type of set","Extraction code","Measurement","CE 14:0","CE 15:0","CE 16:0","CE 16:1","CE 17:0","CE 17:1","CE 18:1","CE 18:2","CE 18:3","CE 19:0","CE 20:0","CE 20:4","CE 20:5","CE 21:1","CE 22:6","Cer d18:1/14:1; Cer d18:1/13:2 (1OH)","Cer d18:1/15:2","Cer d18:1/16:0 (1OH)","Cer d18:1/16:0; Cer d18:1/15:1 (1OH)","Cer d18:1/16:1; Cer d18:1/15:2 (1OH)","Cer d18:1/16:2","Cer d18:1/17:0; Cer d18:1/16:1 (1OH)","Cer d18:1/17:1; Cer d18:1/16:2 (1OH)","Cer d18:1/17:2","Cer d18:1/18:0; Cer d18:1/17:1 (1OH)","Cer d18:1/18:1; Cer d18:1/17:2 (1OH)","Cer d18:1/18:2","Cer d18:1/18:3","Cer d18:1/19:0; Cer d18:1/18:1 (1OH)","Cer d18:1/19:1; Cer d18:1/18:2 (1OH)","Cer d18:1/19:2","Cer d18:1/20:0; Cer d18:1/19:1 (1OH)","Cer d18:1/20:2","Cer d18:1/21:0; Cer d18:1/20:1 (1OH)","Cer d18:1/21:2","Cer d18:1/22:0; Cer d18:1/21:1 (1OH)","Cer d18:1/22:1; Cer d18:1/21:2 (1OH)","Cer d18:1/22:2","Cer d18:1/23:0; Cer d18:1/22:1 (1OH)","Cer d18:1/23:1; Cer d18:1/22:2 (1OH)","Cer d18:1/23:2","Cer d18:1/24:0 (1OH)","Cer d18:1/24:0; Cer d18:1/23:1 (1OH)","Cer d18:1/24:1; Cer d18:1/23:2 (1OH)","Cer d18:1/25:0; Cer d18:1/24:1 (1OH)","Cer d18:1/25:1; Cer d18:1/24:2 (1OH)","Cer d18:1/26:0; Cer d18:1/25:1 (1OH)","Cer d18:1/26:1; Cer d18:1/25:2 (1OH)","Cer d18:1/28:1; Cer d18:1/27:2 (1OH)","DG 28:0","DG 29:0","DG 30:0","DG 30:1","DG 31:0","DG 31:1","DG 32:0","DG 32:1","DG 32:2","DG 32:3","DG 33:0","DG 33:1","DG 33:2","DG 34:0","DG 34:1","DG 34:2","DG 34:3","DG 34:4","DG 35:0","DG 35:1","DG 35:2","DG 35:3","DG 36:0","DG 36:1","DG 36:2","DG 36:3","DG 36:4","DG 36:5","DG 37:0","DG 37:1","DG 37:2","DG 37:3","DG 37:4","DG 37:5","DG 38:0","DG 38:1","DG 38:2","DG 38:3","DG 38:4","DG 38:5","DG 38:6","DG 39:4","DG 40:0","DG 40:1","DG 40:3","DG 40:5","DG 40:6","DG 40:7; DG 39:0","DG 40:8; DG 39:1","DG 40:9; DG 39:2","DG 41:4","DG 42:0","DG 42:1","DG 42:10; DG 41:3","DG 42:2","DG 42:3","DG 42:5","DG 42:6","DG 42:7; DG 41:0","Hex2Cer d18:1/12:2","Hex2Cer d18:1/13:2","Hex2Cer d18:1/14:0 (1OH); HexCer d18:1/27:2","Hex2Cer d18:1/14:2","Hex2Cer d18:1/15:0; Hex2Cer d18:1/14:1 (1OH)","Hex2Cer d18:1/15:2","Hex2Cer d18:1/16:0; Hex2Cer d18:1/15:1 (1OH)","Hex2Cer d18:1/16:1; Hex2Cer d18:1/15:2 (1OH)","Hex2Cer d18:1/17:0; Hex2Cer d18:1/16:1 (1OH)","Hex2Cer d18:1/18:0 (1OH)","Hex2Cer d18:1/18:0; Hex2Cer d18:1/17:1 (1OH)","Hex2Cer d18:1/18:1; Hex2Cer d18:1/17:2 (1OH)","Hex2Cer d18:1/19:0 (1OH)","Hex2Cer d18:1/19:0; Hex2Cer d18:1/18:1 (1OH)","Hex2Cer d18:1/19:1; Hex2Cer d18:1/18:2 (1OH)","Hex2Cer d18:1/19:2","Hex2Cer d18:1/20:2","Hex2Cer d18:1/21:0 (1OH)","Hex2Cer d18:1/21:0; Hex2Cer d18:1/20:1 (1OH)","Hex2Cer d18:1/21:1; Hex2Cer d18:1/20:2 (1OH)","Hex2Cer d18:1/22:0; Hex2Cer d18:1/21:1 (1OH)","Hex2Cer d18:1/24:1; Hex2Cer d18:1/23:2 (1OH)","Hex2Cer d18:1/24:2","HexCer d18:1/14:2","HexCer d18:1/15:2","HexCer d18:1/16:0 (1OH)","HexCer d18:1/16:0; HexCer d18:1/15:1 (1OH)","HexCer d18:1/18:0; HexCer d18:1/17:1 (1OH)","HexCer d18:1/19:0 (1OH)","HexCer d18:1/20:0 (OH)","HexCer d18:1/20:0; HexCer d18:1/19:1 (1OH)","HexCer d18:1/21:2","HexCer d18:1/22:0 (1OH)","HexCer d18:1/22:0; HexCer d18:1/21:1 (1OH)","HexCer d18:1/22:2","HexCer d18:1/23:0 (1OH)","HexCer d18:1/23:0; HexCer d18:1/22:1 (1OH)","HexCer d18:1/23:1; HexCer d18:1/22:2 (1OH)","HexCer d18:1/23:2","HexCer d18:1/24:0 (1OH)","HexCer d18:1/24:0; HexCer d18:1/23:1 (1OH)","HexCer d18:1/24:1; HexCer d18:1/23:2 (1OH)","HexCer d18:1/25:0; HexCer d18:1/24:1 (1OH)","HexCer d18:1/25:1; HexCer d18:1/24:2 (1OH)","LPC 14:0","LPC 16:0","LPC 16:1","LPC 18:0","LPC 18:1","LPC 18:2","LPC 20:3","LPC 20:4","LPC 22:6","LPC 27:0","LPC P-22:0; LPC O-22:1","LPE 16:0","LPE 18:0","LPE 18:1","LPE 18:2","LPE 20:2","LPE 20:4","LPE 20:5","LPE 22:6","LPG 20:0","LPG 27:0","LPG O-18:0; LPG 17:0","LPG O-20:0; LPG 19:0","MG 15:0","MG 16:0","MG 17:0","MG 17:1","MG 18:0","MG 18:1","MG 18:2","MG 18:3","MG 19:0","MG 20:1","MG 21:0","MG 21:1","MG 22:0","MG 22:1","MG 22:3","MG 22:6","MG 23:0","MG 23:1","MG 24:0","MG 24:1","MG22:2","PA 36:0; PA P-38:6","PC 30:0","PC 32:0; PC O-33:0","PC 32:1; PC P-33:0","PC 32:2; PC P-33:1","PC 34:1; PC P-35:0","PC 34:2; PC P-35:1","PC 34:3; PC P-35:2","PC 34:4; PC P-35:3","PC 36:0; PC P-38:6","PC 36:1; PC P-37:0","PC 36:2; PC P-37:1","PC 36:3; PC P-37:2","PC 36:4; PC P-37:3","PC 36:5; PC P-37:4","PC 36:6; PC P-37:5","PC 36:7; PC O-36:0; PC 35:0","PC 38:3; PC P-40:9; PC P-39:2","PC 38:4; PC P-40:10; PC P-29:3","PC 38:5; PC P-39:4","PC 38:6; PC P-39:5","PC 40:10; PC P-40:2; PC 39:3","PC 40:3; PC P-42:9; PC P-41:2","PC 40:4; PC P-42:10; PC P-41:3","PC 40:5; PC P-41:4","PC 40:6; PC P-41:5","PC 42:10; PC P-42:2; PC 41:3","PC 42:5; PC P-43:4","PC 42:9; PC P-42:1; PC 41:2","PC O-32:0; PC-31:0","PC O-34:0;PC 33:0","PC P-32:0; PC-31:1","PC P-32:1; PC-31:2","PC P-34:0; PC 33:1","PC P-34:1; PC 33:2","PC P-36:0; PC 35:1","PC P-36:1; PC 35:2","PC P-36:2; PC 35:3","PC P-36:3; PC 35:4","PC P-36:4; PC 35:5","PC P-36:5; PC 35:6","PC P-38:0; PC 37:1","PC P-38:1; PC 37:2","PC P-38:2; PC 37:3","PC P-38:3; PC 37:4","PC P-38:4; PC 37:5","PC P-38:5; PC 37:6","PC P-40:3; PC 39:4","PC P-40:4; PC 39:5","PC P-40:5; PC 39:6","PC P-42:3; PC 41:4","PC P-42:4; PC 41:5","PC P-42:5; PC 41:6","PE 32:1; PE P-33:0","PE 34:1; PE P-35:0","PE 34:2; PE P-35:1","PE 34:3; PE P-35:2","PE 36:0; PE P-38:6","PE 36:2; PE P-37:1","PE 36:3; PE P-37:2","PE 36:4; PE P-37:3","PE 36:5; PE P-37:4","PE 38:0; PE P-40:6, PE O-39:0","PE 38:1; PE P-40:7; PE P-39:0","PE 38:3; PE P-40:9; PE P-39:2","PE 38:4; PE P-40:10; PE P-29:3","PE 38:5; PE P-39:4","PE 38:6; PE P-39:5","PE 38:7; PE O-38:0; PE 37:0","PE 40:0; PE P-42:6, PE O-41:0","PE 40:3; PE P-42:9; PE P-41:2","PE 40:5; PE P-41:4","PE 40:6; PE P-41:5","PE 40:7; PE O-40:0; PE 39:0","PE 40:8; PE P-40:0; PE 39:1","PE P-34:0; PE 33:1","PE P-36:3; PE 35:4","PE P-36:4; PE 35:5","PE P-38:2; PE 37:3","PE P-38:3; PE 37:4","PE P-38:4; PE 37:5","PE P-38:5; PE 37:6","PE P-40:3; PE 39:4","PE P-40:4; PE 39:5","PE P-40:5; PE 39:6","PE P-42:3; PE 41:4","PG 34:2; PG P-35:1","PI 32:0; PI O-33:0","PI 32:1; PI P-33:0","PI 34:1; PI P-35:0","PI 34:2; PI P-35:1","PI 34:3; PI P-35:2","PI 36:1; PI P-37:0","PI 36:2; PI P-37:1","PI 36:3; PI P-37:2","PI 36:4; PI P-37:3","PI 38:2; PI P-40:8; PI P-39:1","PI 38:3; PI P-40:9; PI P-39:2","PI 38:4; PI P-40:10; PI P-29:3","PI 38:5; PI P-39:4","PI 38:6; PI P-39:5","PI 40:0; PI P-42:6, PI O-41:0","PI 40:4; PI P-42:10; PI P-41:3","PI 40:5; PI P-41:4","PI 40:6; PI P-41:5","PI 42:10; PI P-42:2; PI 41:3","PI 42:3; PI P-43:2","PI 42:6; PI P-43:5","PI P-34:0; PI 33:1","PI P-38:3; PI 37:4","PI P-40:3; PI 39:4","PS 34:0; PS P-36:6","PS 36:4; PS P-37:3","PS 36:5; PS P-37:4","PS 38:6; PS P-39:5","PS 38:7; PS O-38:0; PS 37:0","PS 40:7; PS O-40:0; PS 39:0","PS 40:8; PS P-40:0; PS 39:1","PS 40:9; PS P-40:1; PS 39:2","PS P-32:0; PS-31:1","SM 32:1","SM 32:2","SM 33:1","SM 34:0","SM 34:1","SM 34:2","SM 35:0","SM 35:1","SM 36:1","SM 36:2","SM 37:1","SM 37:2","SM 39:0","SM 39:1","SM 39:2","SM 40:0","SM 40:1","SM 40:2","SM 41:1","SM 41:2","SM 42:2","SM 43:1","TG 42:0","TG 42:1","TG 42:2","TG 42:3","TG 43:0","TG 43:1","TG 44:1","TG 44:2","TG 44:3","TG 45:2","TG 45:3","TG 46:3","TG 46:4","TG 50:1","TG 50:2","TG 50:3","TG 50:4","TG 50:5","TG 51:4","TG 52:0","TG 52:1","TG 52:2","TG 52:3","TG 52:4","TG 52:5","TG 52:6","TG 53:0; TG 54:7","TG 53:1; TG 54:8","TG 53:2; TG 54:9","TG 53:3; TG 54:10","TG 53:4","TG 53:5","TG 54:2","TG 54:3","TG 54:4","TG 54:5","TG 54:6","TG 55:0; TG 56:7","TG 55:1; TG 56:8","TG 55:2; TG 56:9","TG 55:3; TG 56:10","TG 55:4","TG 55:5","TG 55:6","TG 56:2","TG 56:3","TG 56:4","TG 56:5","TG 56:6","TG 57:0; TG 58:7","TG 57:1; TG 58:8","TG 57:2; TG 58:9","TG 57:4","TG 57:5","TG 57:6","TG 58:0","TG 58:1","TG 58:2","TG 58:3","TG 58:4","TG 58:5","TG 58:6","TG 59:0; TG 60:7","TG 59:1; TG 60:8","TG 59:2; TG 60:9","TG 59:3; TG 60:10","TG 59:4","TG 59:5","TG 59:6","TG 60:0","TG 60:1","TG 60:2","TG 60:3","TG 60:4"]
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["Supplementary Table 6d. The statistical evaluation of Phase II (qualification) measured by Shotgun MS. "]
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{"sheet":"Table 7","index":7,"n_rows":488,"n_cols":136,"rows_kept":488}
["Supplementary Table 7. Comparison of the quantitative results obtained with UHPSFC/MS in the discovery (Supplementary Table 2) and qualification phase (Supplementary Table 3a). The RSD for each sample and lipid was caluclated (RSD < 10%: light green, RSD 10-20%: dark green; RSD 20-30%: light blue; RSD 30-40% dark blue; RSD > 40%: red)."]
[]
["Sample code","State","Type","Gender","Type of set","Extraction code","CE 16:1","CE 16:0","CE 18:3","CE 18:2","CE 18:1","CE 20:5","CE 20:4","CE 20:3","CE 22:6","TG 46:3","TG 46:2","TG 46:1","TG 47:2","TG 47:1","TG 48:4","TG 48:3","TG 48:2","TG 48:1","TG 48:0","TG 49:3","TG 49:2","TG 49:1","TG 50:5","TG 50:4","TG 50:3","TG 50:2","TG 50:1","TG 50:0","TG 51:6","TG 51:5","TG 51:4","TG 51:3","TG 51:2","TG 51:1","TG 52:7","TG 52:6","TG 52:5","TG 52:4","TG 52:3","TG 52:2","TG 52:1","TG 53:5","TG 53:4","TG 53:3","TG 53:2","TG 54:8","TG 54:7","TG 54:6","TG 54:5","TG 54:4","TG 54:3","TG 54:2","TG 55:6","TG 55:5","TG 55:4","TG 56:9","TG 56:8","TG 56:7","TG 56:6","TG 56:5","TG 56:4","TG 56:3","TG 56:2","TG 58:10","TG 58:9","TG 58:8","TG 58:7","TG 58:5","DG 32:0  ","DG 34:2  ","DG 34:1  ","DG 34:0  ","DG 36:3  ","DG 36:2  ","Coenzyme Q10  ","MG 16:0","MG 18:0","Cer 40:1","Cer 41:1","Cer 42:2","Cer 42:1","Cer 32:3  OH)","PC 30:0","PC 32:1","PC 32:0","PC O-34:3/P-34:2","PC O-34:2/P-34:1","PC 34:3","PC 34:2","PC 34:1","PC O-36:5/P-36:4","PC O-36:4/P-36:3","PC O-36:3/P-36:2","PC 35:2","PC 35:1","PC 36:5","PC 36:4","PC 36:3","PC 36:2","PC 36:1","PC O-38:6/P-38:5","PC O-38:5/P-38:4","PC 38:6","PC 38:5","PC 38:4","PC 38:3","PC 40:7","PC 40:6","PC 40:5","SM 32:1","SM 34:2","SM 34:1","SM 36:2","SM 36:1","SM 38:1","SM 40:2","SM 40:1","SM 41:2","SM 41:1","SM 42:3","SM 42:2","SM 42:1","LPC 16:0","LPC 18:2","LPC 18:1","LPC 18:0"]
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[]
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{"sheet":"Table 8","index":8,"n_rows":205,"n_cols":12,"rows_kept":205,"merged":[[2,0,2,11],[3,0,3,2],[3,3,3,5],[3,6,3,8],[3,9,3,11],[4,0,4,2],[4,3,4,5],[4,6,4,8],[4,9,4,11]]}
["Supplementary Table 8. Predicted response values for the UHPSFC/MS data set from the qualification phase calculated from OPLS-DA models built with the data from the discovery phase. All variables used passing the criteria for inclusion (138 variables UHPSFC/MS)"]
[]
["Phase I (discovery) used for MDA and Phase II (qualification) was predicted"]
["Males",null,null,"Males",null,null,"Females",null,null,"Females"]
["Kidney",null,null,"Prostate",null,null,"Kidney",null,null,"Breast"]
["Extraction No. ","State","UHPSFC/MS","Extraction No. ","State","UHPSFC/MS","Extraction No. ","State","UHPSFC/MS","Extraction No. ","State","UHPSFC/MS"]
[72,"N",{"v":0.44494,"d":"0.44"},72,"N",{"v":0.383193,"d":"0.38"},8,"N",{"v":0.469171,"d":"0.47"},8,"N",{"v":0.298564,"d":"0.30"}]
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["Sensitivity [%]",null,{"v":90.80459770114942,"d":"90.80"},"Sensitivity [%]",null,{"v":74.6268656716418,"d":"74.63"},"Sensitivity [%]",null,{"v":71.875,"d":"71.88"},"Sensitivity [%]",null,{"v":57.4468085106383,"d":"57.45"}]
["Specificity [%]",null,{"v":61.95652173913044,"d":"61.96"},"Specificity [%]",null,{"v":87.5,"d":"87.50"},"Specificity [%]",null,{"v":86,"d":"86.00"},"Specificity [%]",null,{"v":94,"d":"94.00"}]
["Accuracy [%]",null,{"v":75.97765363128492,"d":"75.98"},"Accuracy [%]",null,{"v":81.63265306122449,"d":"81.63"},"Accuracy [%]",null,{"v":82.57575757575758,"d":"82.58"},"Accuracy [%]",null,{"v":76.28865979381443,"d":"76.29"}]
[]
["*1 Probability scores ≤0.5 predicted as normal (N), and >0.5 predicted as tumor (T). More detailed description of individual regions: >0.75 – very likely T, 0.6-0.75 – likely T, 0.5-0.6 uncertainly T, 0.4-0.5 – uncertainly healthy, 0.25-0.4 – likely healthy, and <0.25 – very likely healthy."]

{"sheet":"Table 9a,b","index":9,"n_rows":230,"n_cols":28,"rows_kept":230,"merged":[[2,0,2,11],[2,12,2,27],[3,0,3,2],[3,3,3,5],[3,6,3,8],[3,9,3,11],[3,12,3,15],[3,16,3,19],[3,20,3,23],[3,24,3,27],[4,0,4,2],[4,3,4,5],[4,6,4,8],[4,9,4,11],[4,12,4,15],[4,16,4,19],[4,20,4,23],[4,24,4,27],[76,0,76,11],[76,12,76,27],[77,0,77,2],[77,3,77,5],[77,6,77,8],[77,9,77,11],[77,12,77,15],[77,16,77,19],[77,20,77,23],[77,24,77,27],[78,0,78,2],[78,3,78,5],[78,6,78,8],[78,9,78,11],[78,12,78,15],[78,16,78,19],[78,20,78,23],[78,24,78,27]]}
["Supplementary Table 9. Predicted response values calculated from OPLS-DA models for all methods and all phases. Common variables for all 3 data sets are used (91 variables). a, Validation sets. "]
[]
["Phase I (discovery)",{"$nulls":11},"Phase II (qualification)"]
["Males",null,null,"Males",null,null,"Females",null,null,"Females",null,null,"Males",{"$nulls":3},"Males",{"$nulls":3},"Females",{"$nulls":3},"Females"]
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[]
["*1 Probability scores ≤0.5 predicted as normal (N), and >0.5 predicted as tumor (T). More detailed description of individual regions: >0.75 – very likely T, 0.6-0.75 – likely T, 0.5-0.6 uncertainly T, 0.4-0.5 – uncertainly healthy, 0.25-0.4 – likely healthy, and <0.25 – very likely healthy."]
[]
["b, Training sets. "]
[]
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[462,"T",{"v":0.811338,"d":"0.81"},{"$nulls":6},362,"T",{"v":0.879835,"d":"0.88"},462,"T",{"v":0.623864,"d":"0.62"},{"v":1.30212,"d":"1.30"},{"$nulls":8},362,"T",{"v":1.11204,"d":"1.11"},{"v":1.17414,"d":"1.17"}]
[{"$nulls":9},368,"T",{"v":1.0773,"d":"1.08"},{"$nulls":12},368,"T",{"v":1.27316,"d":"1.27"},{"v":1.29751,"d":"1.30"}]
[{"$nulls":9},371,"T",{"v":0.845685,"d":"0.85"},{"$nulls":12},371,"T",{"v":0.859378,"d":"0.86"},{"v":1.04488,"d":"1.04"}]
[{"$nulls":9},374,"T",{"v":0.94514,"d":"0.95"},{"$nulls":12},374,"T",{"v":1.17176,"d":"1.17"},{"v":0.996893,"d":"1.00"}]
[{"$nulls":9},380,"T",{"v":0.512053,"d":"0.51"},{"$nulls":12},380,"T",{"v":0.675543,"d":"0.68"},{"v":0.672872,"d":"0.67"}]
[{"$nulls":9},387,"T",{"v":0.639961,"d":"0.64"},{"$nulls":12},387,"T",{"v":0.536609,"d":"0.54"},{"v":0.499771,"d":"0.50"}]
[{"$nulls":9},391,"T",{"v":0.797315,"d":"0.80"},{"$nulls":12},391,"T",{"v":0.81452,"d":"0.81"},{"v":0.771577,"d":"0.77"}]
[{"$nulls":9},395,"T",{"v":0.817276,"d":"0.82"},{"$nulls":12},395,"T",{"v":0.949816,"d":"0.95"},{"v":0.679925,"d":"0.68"}]
[{"$nulls":9},397,"T",{"v":0.436082,"d":"0.44"},{"$nulls":12},397,"T",{"v":0.403315,"d":"0.40"},{"v":0.240953,"d":"0.24"}]
[{"$nulls":9},399,"T",{"v":0.513689,"d":"0.51"},{"$nulls":12},399,"T",{"v":0.473004,"d":"0.47"},{"v":0.133844,"d":"0.13"}]
[{"$nulls":9},403,"T",{"v":0.715422,"d":"0.72"},{"$nulls":12},403,"T",{"v":0.581921,"d":"0.58"},{"v":0.589653,"d":"0.59"}]
[{"$nulls":9},405,"T",{"v":0.913894,"d":"0.91"},{"$nulls":12},405,"T",{"v":1.04519,"d":"1.05"},{"v":0.831196,"d":"0.83"}]
[{"$nulls":9},407,"T",{"v":0.644811,"d":"0.64"},{"$nulls":12},407,"T",{"v":0.596163,"d":"0.60"},{"v":0.583698,"d":"0.58"}]
[{"$nulls":9},411,"T",{"v":0.922438,"d":"0.92"},{"$nulls":12},411,"T",{"v":0.713994,"d":"0.71"},{"v":0.717632,"d":"0.72"}]
[{"$nulls":9},413,"T",{"v":1.47099,"d":"1.47"},{"$nulls":12},413,"T",{"v":1.44105,"d":"1.44"},{"v":1.21001,"d":"1.21"}]
[{"$nulls":9},415,"T",{"v":0.653775,"d":"0.65"},{"$nulls":12},415,"T",{"v":0.752205,"d":"0.75"},{"v":0.566864,"d":"0.57"}]
[{"$nulls":9},419,"T",{"v":1.04546,"d":"1.05"},{"$nulls":12},419,"T",{"v":1.01066,"d":"1.01"},{"v":0.781781,"d":"0.78"}]
[{"$nulls":9},421,"T",{"v":0.632751,"d":"0.63"},{"$nulls":12},421,"T",{"v":0.640506,"d":"0.64"},{"v":0.576549,"d":"0.58"}]
[{"$nulls":9},423,"T",{"v":1.17182,"d":"1.17"},{"$nulls":12},423,"T",{"v":0.822573,"d":"0.82"},{"v":0.823256,"d":"0.82"}]
[{"$nulls":9},427,"T",{"v":1.09013,"d":"1.09"},{"$nulls":12},427,"T",{"v":1.07562,"d":"1.08"},{"v":0.787261,"d":"0.79"}]
[{"$nulls":9},429,"T",{"v":1.12681,"d":"1.13"},{"$nulls":12},429,"T",{"v":1.14438,"d":"1.14"},{"v":0.623538,"d":"0.62"}]
[{"$nulls":9},431,"T",{"v":1.01537,"d":"1.02"},{"$nulls":12},431,"T",{"v":1.12408,"d":"1.12"},{"v":0.898626,"d":"0.90"}]
[{"$nulls":9},435,"T",{"v":1.31142,"d":"1.31"},{"$nulls":12},435,"T",{"v":1.24154,"d":"1.24"},{"v":1.05477,"d":"1.05"}]
[{"$nulls":9},437,"T",{"v":1.35329,"d":"1.35"},{"$nulls":12},437,"T",{"v":1.01834,"d":"1.02"},{"v":0.985422,"d":"0.99"}]
[{"$nulls":9},439,"T",{"v":1.21942,"d":"1.22"},{"$nulls":12},439,"T",{"v":0.996661,"d":"1.00"},{"v":1.0126,"d":"1.01"}]
[{"$nulls":9},445,"T",{"v":1.10204,"d":"1.10"},{"$nulls":12},445,"T",{"v":1.07837,"d":"1.08"},{"v":0.810321,"d":"0.81"}]
[{"$nulls":9},447,"T",{"v":1.11499,"d":"1.11"},{"$nulls":12},447,"T",{"v":1.11463,"d":"1.11"},{"v":0.842808,"d":"0.84"}]
[{"$nulls":9},449,"T",{"v":0.507134,"d":"0.51"},{"$nulls":12},449,"T",{"v":0.551333,"d":"0.55"},{"v":0.404977,"d":"0.40"}]
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["Sensitivity [%]",null,{"v":75.43859649122807,"d":"75.44"},"Sensitivity [%]",null,{"v":88,"d":"88.00"},"Sensitivity [%]",null,{"v":56,"d":"56.00"},"Sensitivity [%]",null,{"v":80,"d":"80.00"},"Sensitivity [%]",null,{"v":78.94736842105263,"d":"78.95"},{"v":94.73684210526316,"d":"94.74"},"Sensitivity [%]",null,{"v":80,"d":"80.00"},{"v":64,"d":"64.00"},"Sensitivity [%]",null,{"v":64,"d":"64.00"},{"v":96,"d":"96.00"},"Sensitivity [%]",null,{"v":82.85714285714286,"d":"82.86"},{"v":77.14285714285714,"d":"77.14"}]
["Specificity [%]",null,{"v":78.33333333333333,"d":"78.33"},"Specificity [%]",null,{"v":95,"d":"95.00"},"Specificity [%]",null,{"v":98.66666666666667,"d":"98.67"},"Specificity [%]",null,{"v":90.66666666666667,"d":"90.67"},"Specificity [%]",null,{"v":83.33333333333333,"d":"83.33"},{"v":69.56521739130434,"d":"69.57"},"Specificity [%]",null,{"v":98.33333333333333,"d":"98.33"},{"v":96.66666666666667,"d":"96.67"},"Specificity [%]",null,{"v":98.66666666666667,"d":"98.67"},{"v":100,"d":"100.00"},"Specificity [%]",null,{"v":97.33333333333333,"d":"97.33"},{"v":90.66666666666667,"d":"90.67"}]
["Accuracy [%]",null,{"v":76.92307692307692,"d":"76.92"},"Accuracy [%]",null,{"v":91.81818181818181,"d":"91.82"},"Accuracy [%]",null,{"v":88,"d":"88.00"},"Accuracy [%]",null,{"v":85.51724137931035,"d":"85.52"},"Accuracy [%]",null,{"v":81.19658119658119,"d":"81.20"},{"v":87.5,"d":"87.50"},"Accuracy [%]",null,{"v":90,"d":"90.00"},{"v":81.81818181818181,"d":"81.82"},"Accuracy [%]",null,{"v":90,"d":"90.00"},{"v":97.95918367346938,"d":"97.96"},"Accuracy [%]",null,{"v":90.34482758620689,"d":"90.34"},{"v":84.13793103448276,"d":"84.14"}]
[]
["*1 Probability scores ≤0.5 predicted as normal (N), and >0.5 predicted as tumor (T). More detailed description of individual regions: >0.75 – very likely T, 0.6-0.75 – likely T, 0.5-0.6 uncertainly T, 0.4-0.5 – uncertainly healthy, 0.25-0.4 – likely healthy, and <0.25 – very likely healthy."]

{"sheet":"Table 10a-c","index":10,"n_rows":340,"n_cols":35,"rows_kept":340,"merged":[[3,0,3,13],[3,14,3,27],[3,28,3,34],[4,0,4,13],[4,14,4,27],[4,28,4,34],[5,0,5,6],[5,7,5,13],[5,14,5,20],[5,21,5,27],[5,28,5,34],[6,0,9,0],[6,1,7,2],[6,3,9,3],[6,4,9,4],[6,5,9,5],[6,6,9,6],[6,7,9,7],[6,8,7,9],[6,10,9,10],[6,11,9,11],[6,12,9,12],[6,13,9,13],[6,14,9,14],[6,15,7,16],[6,17,9,17],[6,18,9,18],[6,19,9,19],[6,20,9,20],[6,21,9,21],[6,22,7,23],[6,24,9,24],[6,25,9,25],[6,26,9,26],[6,27,9,27],[6,28,9,28],[6,29,7,30],[6,31,9,31],[6,32,9,32],[6,33,9,33],[6,34,9,34],[8,1,9,1],[8,2,9,2],[8,8,9,8],[8,9,9,9],[8,15,9,15],[8,16,9,16],[8,22,9,22],[8,23,9,23],[8,29,9,29],[8,30,9,30],[78,0,78,13],[78,14,78,27],[78,28,78,34],[79,0,79,13],[79,14,79,27],[79,28,79,34],[80,0,80,6],[80,7,80,13],[80,14,80,20],[80,21,80,27],[80,28,80,34],[81,0,84,0],[81,1,82,2],[81,3,84,3],[81,4,84,4],[81,5,84,5],[81,6,84,6],[81,7,84,7],[81,8,82,9],[81,10,84,10],[81,11,84,11],[81,12,84,12],[81,13,84,13],[81,14,84,14],[81,15,82,16],[81,17,84,17],[81,18,84,18],[81,19,84,19],[81,20,84,20],[81,21,84,21],[81,22,82,23],[81,24,84,24],[81,25,84,25],[81,26,84,26],[81,27,84,27],[81,28,84,28],[81,29,82,30],[81,31,84,31],[81,32,84,32],[81,33,84,33],[81,34,84,34],[83,1,84,1],[83,2,84,2],[83,8,84,8],[83,9,84,9],[83,15,84,15],[83,16,84,16],[83,22,84,22],[83,23,84,23],[83,29,84,29],[83,30,84,30],[162,0,162,13],[162,14,162,27],[162,28,162,34],[163,0,163,13],[163,14,163,27],[163,28,163,34],[164,0,164,6],[164,7,164,13],[164,14,164,20],[164,21,164,27],[164,28,164,34],[165,0,168,0],[165,1,166,2],[165,3,168,3],[165,4,168,4],[165,5,168,5],[165,6,168,6],[165,7,168,7],[165,8,166,9],[165,10,168,10],[165,11,168,11],[165,12,168,12],[165,13,168,13],[165,14,168,14],[165,15,166,16],[165,17,168,17],[165,18,168,18],[165,19,168,19],[165,20,168,20],[165,21,168,21],[165,22,166,23],[165,24,168,24],[165,25,168,25],[165,26,168,26],[165,27,168,27],[165,28,168,28],[165,29,166,30],[165,31,168,31],[165,32,168,32],[165,33,168,33],[165,34,168,34],[167,1,168,1],[167,2,168,2],[167,8,168,8],[167,9,168,9],[167,15,168,15],[167,16,168,16],[167,22,168,22],[167,23,168,23],[167,29,168,29],[167,30,168,30]]}
["Supplementary Table 10. Statistical parameters calculated from molar concentrations for the training set shown for all methods and all lipids with fold change ≥20%, p-value<0.05, and VIP value >1."]
[" a, Phase I (discovery). "]
[]
["Phase I (discovery)",{"$nulls":13},"Phase I (discovery)",{"$nulls":13},"Phase I (discovery)"]
["UHPSFC/MS",{"$nulls":13},"UHPSFC/MS",{"$nulls":13},"UHPSFC/MS"]
["Males",{"$nulls":6},"Females",{"$nulls":6},"Males",{"$nulls":6},"Females",{"$nulls":6},"Males"]
["Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value","Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value","Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value","Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value","Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value"]
[]
[null,"Healthy control","Kidney",{"$nulls":5},"Healthy control","Kidney",{"$nulls":5},"Healthy control","Breast",{"$nulls":5},"Healthy control","Breast",{"$nulls":5},"Healthy control","Prostate"]
[]
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[]
["* bold when < Bonferroni correction"]
["Bonferroni: (1-((1-α)^(1/N)))"]
["UHPSFC/MS",{"$f":"(1-((1-0.05)^(1/138)))","v":3.71621470669381E-4}]
[]
[" b, Phase II (qualification)- UHPSFC/MS. "]
[]
["Phase II (qualification)",{"$nulls":13},"Phase II (qualification)",{"$nulls":13},"Phase II (qualification)"]
["UHPSFC/MS",{"$nulls":13},"UHPSFC/MS",{"$nulls":13},"UHPSFC/MS"]
["Males",{"$nulls":6},"Females",{"$nulls":6},"Males",{"$nulls":6},"Females",{"$nulls":6},"Males"]
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[]
[null,"Healthy control","Kidney",{"$nulls":5},"Healthy control","Kidney",{"$nulls":5},"Healthy control","Breast",{"$nulls":5},"Healthy control","Breast",{"$nulls":5},"Healthy control","Prostate"]
[]
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[]
["* bold when < Bonferroni correction"]
["Bonferroni: (1-((1-α)^(1/N)))"]
["UHPSFC/MS",{"$f":"(1-((1-0.05)^(1/138)))","v":3.71621470669381E-4}]
[]
[" c, Phase II (qualification) - Shotgun MS. "]
[]
["Phase II (qualification)",{"$nulls":13},"Phase II (qualification)",{"$nulls":13},"Phase II (qualification)"]
["Shotgun MS",{"$nulls":13},"Shotgun MS",{"$nulls":13},"Shotgun MS"]
["Males",{"$nulls":6},"Females",{"$nulls":6},"Males",{"$nulls":6},"Females",{"$nulls":6},"Males"]
["Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value","Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value","Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value","Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value","Lipid species","Molar concentration [nmol/mL]",null,"Fold change","P-value*","T-value","VIP value"]
[]
[null,"Healthy control","Kidney",{"$nulls":5},"Healthy control","Kidney",{"$nulls":5},"Healthy control","Breast",{"$nulls":5},"Healthy control","Breast",{"$nulls":5},"Healthy control","Prostate"]
[]
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[]
[]
["* bold when < Bonferroni correction"]
["Bonferroni: (1-((1-α)^(1/N)))"]
["Shotgun MS",{"$f":"(1-((1-0.05)^(1/412)))","v":1.2449053775820396E-4}]

{"sheet":"Table 11a,b","index":11,"n_rows":230,"n_cols":28,"rows_kept":230,"merged":[[2,0,2,11],[2,12,2,27],[3,0,3,2],[3,3,3,5],[3,6,3,8],[3,9,3,11],[3,12,3,15],[3,16,3,19],[3,20,3,23],[3,24,3,27],[4,0,4,2],[4,3,4,5],[4,6,4,8],[4,9,4,11],[4,12,4,15],[4,16,4,19],[4,20,4,23],[4,24,4,27],[76,0,76,11],[76,12,76,27],[77,0,77,2],[77,3,77,5],[77,6,77,8],[77,9,77,11],[77,12,77,15],[77,16,77,19],[77,20,77,23],[77,24,77,27],[78,0,78,2],[78,3,78,5],[78,6,78,8],[78,9,78,11],[78,12,78,15],[78,16,78,19],[78,20,78,23],[78,24,78,27]]}
["Supplementary Table 11. Predicted response values calculated from OPLS-DA models for all methods and all phases. Only variables included, which are significant according to the Bonferroni correction in >10 from 15 models (considering all cancer types and data sets-29 variables). SM 38:1 and SM 42:1 were excluded as those variables were only significant for UHPSFC/MS data sets (10/10) and therefore a method bias can not be excluded. a, Validation sets. "]
[]
["Phase I (discovery)",{"$nulls":11},"Phase II (qualification)"]
["Males",null,null,"Males",null,null,"Females",null,null,"Females",null,null,"Males",{"$nulls":3},"Males",{"$nulls":3},"Females",{"$nulls":3},"Females"]
["Kidney",null,null,"Prostate",null,null,"Kidney",null,null,"Breast",null,null,"Kidney",{"$nulls":3},"Prostate",{"$nulls":3},"Kidney",{"$nulls":3},"Breast"]
["Extraction No. ","State","UHPSFC/MS","Extraction No. ","State","UHPSFC/MS","Extraction No. ","State","UHPSFC/MS","Extraction No. ","State","UHPSFC/MS","Extraction No. ","State","UHPSFC/MS","Shotgun MS (LR)","Extraction No. ","State","UHPSFC/MS","Shotgun MS (LR)","Extraction No. ","State","UHPSFC/MS","Shotgun MS (LR)","Extraction No. ","State","UHPSFC/MS","Shotgun MS (LR)"]
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[]
["*1 Probability scores ≤0.5 predicted as normal (N), and >0.5 predicted as tumor (T). More detailed description of individual regions: >0.75 – very likely T, 0.6-0.75 – likely T, 0.5-0.6 uncertainly T, 0.4-0.5 – uncertainly healthy, 0.25-0.4 – likely healthy, and <0.25 – very likely healthy."]
[]
["b, Training sets. "]
[]
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["Specificity [%]",null,{"v":81.66666666666667,"d":"81.67"},"Specificity [%]",null,{"v":95,"d":"95.00"},"Specificity [%]",null,{"v":100,"d":"100.00"},"Specificity [%]",null,{"v":90.66666666666667,"d":"90.67"},"Specificity [%]",null,{"v":81.66666666666667,"d":"81.67"},{"v":34.78260869565217,"d":"34.78"},"Specificity [%]",null,{"v":98.33333333333333,"d":"98.33"},{"v":95,"d":"95.00"},"Specificity [%]",null,{"v":100,"d":"100.00"},{"v":91.66666666666667,"d":"91.67"},"Specificity [%]",null,{"v":92,"d":"92.00"},{"v":92,"d":"92.00"}]
["Accuracy [%]",null,{"v":82.05128205128206,"d":"82.05"},"Accuracy [%]",null,{"v":89.0909090909091,"d":"89.09"},"Accuracy [%]",null,{"v":93,"d":"93.00"},"Accuracy [%]",null,{"v":79.3103448275862,"d":"79.31"},"Accuracy [%]",null,{"v":79.48717948717949,"d":"79.49"},73.75,"Accuracy [%]",null,{"v":83.63636363636364,"d":"83.64"},{"v":83.63636363636364,"d":"83.64"},"Accuracy [%]",null,{"v":94,"d":"94.00"},{"v":85.71428571428571,"d":"85.71"},"Accuracy [%]",null,{"v":80.6896551724138,"d":"80.69"},{"v":79.3103448275862,"d":"79.31"}]
[]
["*1 Probability scores ≤0.5 predicted as normal (N), and >0.5 predicted as tumor (T). More detailed description of individual regions: >0.75 – very likely T, 0.6-0.75 – likely T, 0.5-0.6 uncertainly T, 0.4-0.5 – uncertainly healthy, 0.25-0.4 – likely healthy, and <0.25 – very likely healthy."]

{"sheet":"Table 12a,b","index":12,"n_rows":230,"n_cols":28,"rows_kept":230,"merged":[[2,0,2,11],[2,12,2,27],[3,0,3,2],[3,3,3,5],[3,6,3,8],[3,9,3,11],[3,12,3,15],[3,16,3,19],[3,20,3,23],[3,24,3,27],[4,0,4,2],[4,3,4,5],[4,6,4,8],[4,9,4,11],[4,12,4,15],[4,16,4,19],[4,20,4,23],[4,24,4,27],[76,0,76,11],[76,12,76,27],[77,0,77,2],[77,3,77,5],[77,6,77,8],[77,9,77,11],[77,12,77,15],[77,16,77,19],[77,20,77,23],[77,24,77,27],[78,0,78,2],[78,3,78,5],[78,6,78,8],[78,9,78,11],[78,12,78,15],[78,16,78,19],[78,20,78,23],[78,24,78,27]]}
["Supplementary Table 12. Predicted response values calculated from OPLS-DA models for all methods and all phases. Only variables included, which are significant according to the Bonferroni correction in >14 from 15 models (considering all cancer types and data sets-7 variables).a, Validation sets. "]
[]
["Phase I (discovery)",{"$nulls":11},"Phase II (qualification)"]
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[]
["*1 Probability scores ≤0.5 predicted as normal (N), and >0.5 predicted as tumor (T). More detailed description of individual regions: >0.75 – very likely T, 0.6-0.75 – likely T, 0.5-0.6 uncertainly T, 0.4-0.5 – uncertainly healthy, 0.25-0.4 – likely healthy, and <0.25 – very likely healthy."]
[]
["b, Training sets. "]
[]
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["Specificity [%]",null,{"v":95,"d":"95.00"},"Specificity [%]",null,{"v":93.33333333333333,"d":"93.33"},"Specificity [%]",null,{"v":100,"d":"100.00"},"Specificity [%]",null,{"v":90.66666666666667,"d":"90.67"},"Specificity [%]",null,{"v":96.66666666666667,"d":"96.67"},{"v":47.82608695652174,"d":"47.83"},"Specificity [%]",null,{"v":96.66666666666667,"d":"96.67"},{"v":93.33333333333333,"d":"93.33"},"Specificity [%]",null,{"v":98.66666666666667,"d":"98.67"},{"v":87.5,"d":"87.50"},"Specificity [%]",null,{"v":90.66666666666667,"d":"90.67"},{"v":85.33333333333333,"d":"85.33"}]
["Accuracy [%]",null,{"v":84.61538461538461,"d":"84.62"},"Accuracy [%]",null,{"v":83.63636363636364,"d":"83.64"},"Accuracy [%]",null,{"v":84,"d":"84.00"},"Accuracy [%]",null,{"v":77.24137931034483,"d":"77.24"},"Accuracy [%]",null,{"v":83.76068376068376,"d":"83.76"},{"v":77.21518987341773,"d":"77.22"},"Accuracy [%]",null,{"v":81.81818181818181,"d":"81.82"},{"v":82.72727272727273,"d":"82.73"},"Accuracy [%]",null,{"v":83,"d":"83.00"},{"v":79.59183673469387,"d":"79.59"},"Accuracy [%]",null,{"v":78.62068965517241,"d":"78.62"},{"v":76.55172413793103,"d":"76.55"}]
[]
["*1 Probability scores ≤0.5 predicted as normal (N), and >0.5 predicted as tumor (T). More detailed description of individual regions: >0.75 – very likely T, 0.6-0.75 – likely T, 0.5-0.6 uncertainly T, 0.4-0.5 – uncertainly healthy, 0.25-0.4 – likely healthy, and <0.25 – very likely healthy."]

{"sheet":"Table 13a-h","index":13,"n_rows":116,"n_cols":7,"rows_kept":116,"merged":[[2,0,3,0],[2,1,3,1],[2,4,3,4],[4,0,11,0],[12,0,19,0],[23,0,24,0],[23,1,24,1],[23,4,24,4],[25,0,32,0],[33,0,40,0],[44,0,45,0],[44,1,45,1],[44,4,45,4],[46,0,53,0],[54,0,61,0],[65,0,66,0],[65,1,66,1],[65,4,66,4],[67,0,74,0],[75,0,82,0],[87,1,87,2],[88,0,89,0],[88,1,88,2],[89,1,89,2],[90,0,91,0],[90,1,90,2],[91,1,91,2],[95,1,95,2],[96,0,97,0],[96,1,96,2],[97,1,97,2],[98,0,99,0],[98,1,98,2],[99,1,99,2],[103,1,103,2],[104,0,105,0],[104,1,104,2],[105,1,105,2],[106,0,107,0],[106,1,106,2],[107,1,107,2],[111,1,111,2],[112,0,113,0],[112,1,112,2],[113,1,113,2],[114,0,115,0],[114,1,114,2],[115,1,115,2]]}
["Supplementary Table 13a. Prediction of the cancer type using the OPLS-DA models. All variables used passing the criteria for inclusion (138 variables UHPSFC/MS and 412 variables for Shotgun MS)."]
[]
[null,"Male ","Phase I (discovery)","Phase II (qualification)","Female","Phase I (discovery)","Phase II (qualification)"]
[null,null,"UHPSFC/MS","UHPSFC/MS",null,"UHPSFC/MS","UHPSFC/MS"]
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[]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Kidney",{"v":66.66666666666667,"d":"66.67"},{"v":70.17543859649123,"d":"70.18"},"Kidney",{"v":24,"d":"24.00"},{"v":44,"d":"44.00"}]
[null,"Prostate",{"v":66,"d":"66.00"},{"v":46,"d":"46.00"},"Breast",{"v":81.42857142857143,"d":"81.43"},{"v":74.28571428571429,"d":"74.29"}]
[]
[null,"Accuracy",{"v":66.46706586826348,"d":"66.47"},{"v":66.46706586826348,"d":"66.47"},"Accuracy",{"v":77.6470588235294,"d":"77.65"},{"v":77.05882352941177,"d":"77.06"}]
[]
["Validation set","Specificity",68.75,{"v":78.125,"d":"78.13"},"Specificity",{"v":84,"d":"84.00"},{"v":88,"d":"88.00"}]
[]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Kidney",{"v":50,"d":"50.00"},{"v":66.66666666666667,"d":"66.67"},"Kidney",{"v":42.857142857142854,"d":"42.86"},{"v":42.857142857142854,"d":"42.86"}]
[null,"Prostate",{"v":58.8235294117647,"d":"58.82"},{"v":41.1764705882353,"d":"41.18"},"Breast",{"v":66.66666666666667,"d":"66.67"},{"v":75,"d":"75.00"}]
[]
[null,"Accuracy",{"v":59.49367088607595,"d":"59.49"},{"v":65.82278481012658,"d":"65.82"},"Accuracy",{"v":71.42857142857143,"d":"71.43"},{"v":76.78571428571429,"d":"76.79"}]
[]
[]
["Supplementary Table 13b. Prediction of the cancer type using the OPLS-DA models. Common variables for all 3 data sets are used (91 variables)."]
[]
[null,"Male ","Phase I (discovery)","Phase II (qualification)","Female","Phase I (discovery)","Phase II (qualification)"]
[null,null,"UHPSFC/MS","UHPSFC/MS",null,"UHPSFC/MS","UHPSFC/MS"]
["Training set","Specificity",{"v":81.66666666666667,"d":"81.67"},{"v":81.66666666666667,"d":"81.67"},"Specificity",{"v":90.66666666666667,"d":"90.67"},{"v":89.33333333333333,"d":"89.33"}]
[]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Kidney",{"v":73.6842105263158,"d":"73.68"},{"v":68.42105263157895,"d":"68.42"},"Kidney",{"v":20,"d":"20.00"},{"v":32,"d":"32.00"}]
[null,"Prostate",{"v":66,"d":"66.00"},{"v":42,"d":"42.00"},"Breast",{"v":82.85714285714286,"d":"82.86"},{"v":75.71428571428571,"d":"75.71"}]
[]
[null,"Accuracy",{"v":74.25149700598803,"d":"74.25"},{"v":65.26946107784431,"d":"65.27"},"Accuracy",{"v":77.05882352941177,"d":"77.06"},{"v":75.29411764705883,"d":"75.29"}]
[]
["Validation set","Specificity",{"v":75,"d":"75.00"},{"v":84.375,"d":"84.38"},"Specificity",{"v":92,"d":"92.00"},{"v":92,"d":"92.00"}]
[]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Kidney",{"v":66.66666666666667,"d":"66.67"},{"v":66.66666666666667,"d":"66.67"},"Kidney",{"v":14.285714285714286,"d":"14.29"},{"v":28.571428571428573,"d":"28.57"}]
[null,"Prostate",{"v":64.70588235294117,"d":"64.71"},{"v":41.1764705882353,"d":"41.18"},"Breast",{"v":79.16666666666667,"d":"79.17"},{"v":75,"d":"75.00"}]
[]
[null,"Accuracy",{"v":69.62025316455696,"d":"69.62"},{"v":68.35443037974683,"d":"68.35"},"Accuracy",{"v":76.78571428571429,"d":"76.79"},{"v":76.78571428571429,"d":"76.79"}]
[]
[]
["Supplementary Table 13c. Prediction of the cancer type using the OPLS-DA models. Only variables included, which are significant according to the Bonferroni correction in >10 from 15 models (considering all cancer types and data sets-29 variables). SM 38:1 and SM 42:1 were excluded as those variables were only significant for UHPSFC/MS data sets (10/10) and therefore a method bias can not be excluded. "]
[]
[null,"Male ","Phase I (discovery)","Phase II (qualification)","Female","Phase I (discovery)","Phase II (qualification)"]
[null,null,"UHPSFC/MS","UHPSFC/MS",null,"UHPSFC/MS","UHPSFC/MS"]
["Training set","Specificity",{"v":73.33333333333333,"d":"73.33"},{"v":83.33333333333333,"d":"83.33"},"Specificity",{"v":92,"d":"92.00"},{"v":96,"d":"96.00"}]
[]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Kidney",{"v":49.12280701754386,"d":"49.12"},{"v":50.87719298245614,"d":"50.88"},"Kidney",{"v":8,"d":"8.00"},{"v":16,"d":"16.00"}]
[null,"Prostate",{"v":54,"d":"54.00"},{"v":40,"d":"40.00"},"Breast",{"v":60,"d":"60.00"},{"v":70,"d":"70.00"}]
[]
[null,"Accuracy",{"v":59.2814371257485,"d":"59.28"},{"v":59.2814371257485,"d":"59.28"},"Accuracy",{"v":66.47058823529412,"d":"66.47"},{"v":73.52941176470588,"d":"73.53"}]
[]
["Validation set","Specificity",{"v":75,"d":"75.00"},{"v":96.875,"d":"96.88"},"Specificity",{"v":88,"d":"88.00"},{"v":80,"d":"80.00"}]
[]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Kidney",{"v":60,"d":"60.00"},{"v":53.333333333333336,"d":"53.33"},"Kidney",{"v":0,"d":"0.00"},{"v":14.285714285714286,"d":"14.29"}]
[null,"Prostate",{"v":52.94117647058823,"d":"52.94"},{"v":41.1764705882353,"d":"41.18"},"Breast",{"v":62.5,"d":"62.50"},{"v":75,"d":"75.00"}]
[]
[null,"Accuracy",{"v":64.55696202531645,"d":"64.56"},{"v":68.35443037974683,"d":"68.35"},"Accuracy",{"v":66.07142857142857,"d":"66.07"},{"v":69.64285714285714,"d":"69.64"}]
[]
[]
["Supplementary Table 13d. Prediction of the cancer type using the OPLS-DA models. Only variables included, which are significant according to the Bonferroni correction in >14 from 15 models (considering all cancer types and data sets-7 variables)."]
[]
[null,"Male ","Phase I (discovery)","Phase II (qualification)","Female","Phase I (discovery)","Phase II (qualification)"]
[null,null,"UHPSFC/MS","UHPSFC/MS",null,"UHPSFC/MS","UHPSFC/MS"]
["Training set","Specificity",{"v":95,"d":"95.00"},{"v":93.33333333333333,"d":"93.33"},"Specificity","-","-"]
[]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Kidney",{"v":63.1578947368421,"d":"63.16"},{"v":49.12280701754386,"d":"49.12"},"Kidney","-","-"]
[null,"Prostate",{"v":4,"d":"4.00"},{"v":32,"d":"32.00"},"Breast","-","-"]
[]
[null,"Accuracy",{"v":56.88622754491018,"d":"56.89"},{"v":59.880239520958085,"d":"59.88"},"Accuracy","-","-"]
[]
["Validation set","Specificity",93.75,93.75,"Specificity","-","-"]
[]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Kidney",{"v":60,"d":"60.00"},{"v":66.66666666666667,"d":"66.67"},"Kidney","-","-"]
[null,"Prostate",{"v":0,"d":"0.00"},{"v":41.1764705882353,"d":"41.18"},"Breast","-","-"]
[]
[null,"Accuracy",{"v":60.75949367088607,"d":"60.76"},{"v":72.15189873417721,"d":"72.15"},"Accuracy","-","-"]
[]
[]
[]
["e, Summary of predictive components and orthogonal in X components (Training Set). All variables used passing the criteria for inclusion (138 variables UHPSFC/MS)."]
[]
["Model","Phase",null,"Method","Predictive + Orthogonal in X components"]
["M cancers (N, kidney, prostate)","Phase I (discovery)",null,"UHPSFC/MS","2+2+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","2+2+0"]
["F cancers (N, kidney, breast)","Phase I (discovery)",null,"UHPSFC/MS","2+3+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","2+2+0"]
[]
["f, Summary of predictive components and orthogonal in X components (Training Set). Common variables for all 3 data sets are used (91 variables)."]
[]
["Model","Phase",null,"Method","Predictive + Orthogonal in X components"]
["M cancers (N, kidney, prostate)","Phase I (discovery)",null,"UHPSFC/MS","2+4+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","2+1+0"]
["F cancers (N, kidney, breast)","Phase I (discovery)",null,"UHPSFC/MS","2+2+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","2+2+0"]
[]
["g, Summary of predictive components and orthogonal in X components (Training Set). Only variables included, which are significant according to the Bonferroni correction in >10 from 15 models (considering all cancer types and data sets-29 variables). SM 38:1 and SM 42:1 were excluded as those variables were only significant for UHPSFC/MS data sets (10/10) and therefore a method bias can not be excluded. "]
[]
["Model","Phase",null,"Method","Predictive + Orthogonal in X components"]
["M cancers (N, kidney, prostate)","Phase I (discovery)",null,"UHPSFC/MS","2+1+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","2+0+0"]
["F cancers (N, kidney, breast)","Phase I (discovery)",null,"UHPSFC/MS","2+0+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","2+3+0"]
[]
["h, Summary of predictive components and orthogonal in X components (Training Set). Only variables included, which are significant according to the Bonferroni correction in >14 from 15 models (considering all cancer types and data sets-7 variables).  "]
[]
["Model","Phase",null,"Method","Predictive + Orthogonal in X components"]
["M cancers (N, kidney, prostate)","Phase I (discovery)",null,"UHPSFC/MS","1+2+0"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","2+1+0"]
["F cancers (N, kidney, breast)","Phase I (discovery)",null,"UHPSFC/MS","-"]
[null,"Phase II (qualification)",null,"UHPSFC/MS","-"]

{"sheet":"Table 14a-c","index":14,"n_rows":58,"n_cols":7,"rows_kept":58,"merged":[[2,0,4,0],[2,1,4,1],[2,2,2,3],[2,4,4,4],[2,5,2,6],[5,0,11,0],[12,0,18,0],[22,0,24,0],[22,1,24,1],[22,2,22,3],[22,4,24,4],[22,5,22,6],[25,0,31,0],[32,0,38,0],[42,0,44,0],[42,1,44,1],[42,2,42,3],[42,4,44,4],[42,5,42,6],[45,0,51,0],[52,0,58,0]]}
["Supplementary Table 14a. OPLS-DA models of cancer types. All variables used passing the criteria for inclusion (138 variables UHPSFC/MS and 412 variables for Shotgun MS)."]
[]
[null,"Male ","Prostate vs. Kidney",null,"Female ","Breast vs. Kidney"]
[null,null,"Phase I (discovery)","Phase II (qualification)",null,"Phase I (discovery)","Phase II (qualification)"]
[null,null,"UHPSFC/MS","UHPSFC/MS",null,"UHPSFC/MS","UHPSFC/MS"]
["Training set"]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Prostate",{"v":84,"d":"84.00"},{"v":84,"d":"84.00"},"Breast",{"v":95.71428571428571,"d":"95.71"},{"v":100,"d":"100.00"}]
[null,"Kidney",{"v":80.70175438596492,"d":"80.70"},{"v":82.45614035087719,"d":"82.46"},"Kidney",{"v":80,"d":"80.00"},{"v":28,"d":"28.00"}]
[]
[null,"Accuracy",{"v":82.24299065420561,"d":"82.24"},{"v":83.17757009345794,"d":"83.18"},"Accuracy",{"v":91.57894736842105,"d":"91.58"},{"v":81.05263157894737,"d":"81.05"}]
[]
["Validation set"]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Prostate",{"v":76.47058823529412,"d":"76.47"},{"v":88.23529411764706,"d":"88.24"},"Breast",{"v":100,"d":"100.00"},{"v":100,"d":"100.00"}]
[null,"Kidney",{"v":56.666666666666664,"d":"56.67"},{"v":66.66666666666667,"d":"66.67"},"Kidney",{"v":85.71428571428571,"d":"85.71"},{"v":14.285714285714286,"d":"14.29"}]
[]
[null,"Accuracy",{"v":63.829787234042556,"d":"63.83"},{"v":74.46808510638297,"d":"74.47"},"Accuracy",{"v":96.7741935483871,"d":"96.77"},{"v":80.64516129032258,"d":"80.65"}]
[]
[]
["Supplementary Table 14b. OPLS-DA models of cancer types. Common variables for all 3 data sets are used (91 variables)."]
[]
[null,"Male ","Prostate vs. Kidney",null,"Female ","Breast vs. Kidney"]
[null,null,"Phase I (discovery)","Phase II (qualification)",null,"Phase I (discovery)","Phase II (qualification)"]
[null,null,"UHPSFC/MS","UHPSFC/MS",null,"UHPSFC/MS","UHPSFC/MS"]
["Training set"]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Prostate",{"v":74,"d":"74.00"},{"v":82,"d":"82.00"},"Breast",{"v":94.28571428571429,"d":"94.29"},{"v":98.57142857142857,"d":"98.57"}]
[null,"Kidney",{"v":80.70175438596492,"d":"80.70"},{"v":78.94736842105263,"d":"78.95"},"Kidney",{"v":84,"d":"84.00"},{"v":68,"d":"68.00"}]
[]
[null,"Accuracy",{"v":77.57009345794393,"d":"77.57"},{"v":80.37383177570094,"d":"80.37"},"Accuracy",{"v":91.57894736842105,"d":"91.58"},{"v":90.52631578947368,"d":"90.53"}]
[]
["Validation set"]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Prostate",{"v":70.58823529411765,"d":"70.59"},{"v":88.23529411764706,"d":"88.24"},"Breast",{"v":100,"d":"100.00"},{"v":95.83333333333333,"d":"95.83"}]
[null,"Kidney",{"v":70,"d":"70.00"},{"v":60,"d":"60.00"},"Kidney",{"v":85.71428571428571,"d":"85.71"},{"v":85.71428571428571,"d":"85.71"}]
[]
[null,"Accuracy",{"v":70.2127659574468,"d":"70.21"},{"v":70.2127659574468,"d":"70.21"},"Accuracy",{"v":96.7741935483871,"d":"96.77"},{"v":93.54838709677419,"d":"93.55"}]
[]
[]
["Supplementary Table 14c. OPLS-DA models of cancer types. Only variables included, which are significant according to the Bonferroni correction in >10 from 15 models (considering all cancer types and data sets-29 variables). SM 38:1 and SM 42:1 were excluded as those variables were only significant for UHPSFC/MS data sets (10/10) and therefore a method bias can not be excluded. "]
[]
[null,"Male ","Prostate vs. Kidney",null,"Female ","Breast vs. Kidney"]
[null,null,"Phase I (discovery)","Phase II (qualification)",null,"Phase I (discovery)","Phase II (qualification)"]
[null,null,"UHPSFC/MS","UHPSFC/MS",null,"UHPSFC/MS","UHPSFC/MS"]
["Training set"]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Prostate","-","-","Breast",{"v":95.71428571428571,"d":"95.71"},{"v":95.71428571428571,"d":"95.71"}]
[null,"Kidney","-","-","Kidney",{"v":36,"d":"36.00"},{"v":64,"d":"64.00"}]
[]
[null,"Accuracy","-","-","Accuracy",{"v":80,"d":"80.00"},{"v":87.36842105263158,"d":"87.37"}]
[]
["Validation set"]
[null,"Sensitivity",null,null,"Sensitivity"]
[null,"Prostate","-","-","Breast",{"v":100,"d":"100.00"},{"v":100,"d":"100.00"}]
[null,"Kidney","-","-","Kidney",{"v":14.285714285714286,"d":"14.29"},{"v":42.857142857142854,"d":"42.86"}]
[]
[null,"Accuracy","-","-","Accuracy",{"v":80.64516129032258,"d":"80.65"},{"v":87.09677419354838,"d":"87.10"}]

{"sheet":"Table 15","index":15,"n_rows":32,"n_cols":5,"rows_kept":32,"merged":[[2,0,5,0],[2,1,5,1],[2,2,5,2],[2,3,5,3],[2,4,5,4]]}
["Supplementary Table 15. Concentrations of the internal standard (IS) mixture used for the lipidomic quantitation."]
[]
["IS","Molecular weight","Stock concentration [µg/µL]","Volume [µL]","Concentration in plasma [nmol/mL]"]
[]
[]
[]
["CE 16:0 D7",{"v":631.6285,"d":"631.63"},2,200,{"v":443.29855286770623,"d":"443.3"}]
["Cer 30:1",{"v":481.4495,"d":"481.45"},2,4,{"v":11.631541833567177,"d":"11.6"}]
["DG 24:2",{"v":452.3502,"d":"452.35"},2,15,{"v":46.42420850040522,"d":"46.4"}]
["Hex2Cer 30:1",{"v":805.5551,"d":"805.56"},2,4,{"v":6.9517280692531145,"d":"7.0"}]
["HexCer 30:1",{"v":643.5023,"d":"643.50"},2.1,3,{"v":6.853122358692424,"d":"6.9"}]
["Cholesterol D7",{"v":393.6988,"d":"393.70"},2,300,{"v":1066.8053852335847,"d":"1066.8"}]
["PI 33:1 D7",{"v":846.596,"d":"846.60"},1,16,{"v":13.229450647061881,"d":"13.2"}]
["LPC 17:0",{"v":509.3481,"d":"509.35"},2.1,20,{"v":57.72083963796076,"d":"57.7"}]
["LPE 14:0",{"v":425.2542,"d":"425.25"},2,4,{"v":13.168594219645566,"d":"13.2"}]
["LPG 14:0a",{"v":478.2308,"d":"478.23"},2.1,14,{"v":43.03361473163167,"d":"43.0"}]
["MG 19:1",{"v":370.3083,"d":"370.31"},2,30,{"v":113.41900789153254,"d":"113.4"}]
["PA 28:0",{"v":614.3924,"d":"614.39"},2,4,{"v":9.11469608022495,"d":"9.1"}]
["PC 28:0",{"v":677.4996,"d":"677.50"},2,60,{"v":123.98531305405938,"d":"124.0"}]
["PE 28:0",{"v":635.4526,"d":"635.45"},2,4,{"v":8.812616393417857,"d":"8.8"}]
["PG 28:0a",{"v":688.4291,"d":"688.43"},2,2,{"v":4.067230743151328,"d":"4.1"}]
["PS 28:0a",{"v":701.4244,"d":"701.42"},2,4,{"v":7.983754200737813,"d":"8.0"}]
["SM 30:1",{"v":646.505,"d":"646.51"},2,20,{"v":43.309796521295276,"d":"43.3"}]
["SHexCer 30:1b",{"v":740.4857,"d":"740.49"},0.25,0.28,{"v":0.06617278362026438,"d":"0.1"}]
["TG 57:3",{"v":926.8302,"d":"926.83"},2,75,{"v":113.28935979859094,"d":"113.3"}]
["PC 44:2",{"v":897.719,"d":"897.72"},2,80,{"v":124.7606433639034,"d":"124.8"}]
["Solvent",null,"CHCl3:IPA      (2:8, v/v)",140.72000000000003]
["Total volume",null,null,1000]
[]
[]
["a IS is the sodium salt."]
["b IS is the ammonium salt."]