['Famotidine-B-Chemical', ',-O', 'associated-O', 'delirium-B-Disease', '.-O']
['A-O', 'series-O', 'of-O', 'six-O', 'cases-O', '.-O']
['Famotidine-B-Chemical', 'is-O', 'a-O', 'histamine-B-Chemical', 'H2-O', ',-O', 'receptor-O', 'antagonist-O', 'used-O', 'in-O', 'inpatient-O', 'settings-O', 'for-O', 'prevention-O', 'of-O', 'stress-B-Disease', 'ulcers-I-Disease', 'and-O', 'is-O', 'showing-O', 'increasing-O', 'popularity-O', 'because-O', 'of-O', 'its-O', 'low-O', 'cost-O', '.-O']
['Although-O', 'all-O', 'of-O', 'the-O', 'currently-O', 'available-O', 'H2-O', ',-O', 'receptor-O', 'antagonists-O', 'have-O', 'shown-O', 'the-O', 'propensity-O', 'to-O', 'cause-O', 'delirium-B-Disease', ',-O', 'only-O', 'two-O', 'previously-O', 'reported-O', 'cases-O', 'have-O', 'been-O', 'associated-O', 'with-O', 'famotidine-B-Chemical', '.-O']
['The-O', 'authors-O', 'report-O', 'on-O', 'six-O', 'cases-O', 'of-O', 'famotidine-B-Chemical', ',-O', 'associated-O', 'delirium-B-Disease', 'in-O', 'hospitalized-O', 'patients-O', 'who-O', 'cleared-O', 'completely-O', 'upon-O', 'removal-O', 'of-O', 'famotidine-B-Chemical', '.-O']
['The-O', 'pharmacokinetics-O', 'of-O', 'famotidine-B-Chemical', 'are-O', 'reviewed-O', ',-O', 'with-O', 'no-O', 'change-O', 'in-O', 'its-O', 'metabolism-O', 'in-O', 'the-O', 'elderly-O', 'population-O', 'seen-O', '.-O']
['The-O', 'implications-O', 'of-O', 'using-O', 'famotidine-B-Chemical']
['Indomethacin-B-Chemical', 'induced-O', 'hypotension-B-Disease', 'in-O', 'sodium-B-Chemical', 'and-O', 'volume-O', 'depleted-O', 'rats-O', '.-O']
['After-O', 'a-O', 'single-O', 'oral-O', 'dose-O', 'of-O', '4-O', 'mg-O', '/-O', 'kg-O', 'indomethacin-B-Chemical', '(-O', 'IDM-O', ')-O', 'to-O', 'sodium-B-Chemical', 'and-O', 'volume-O', 'depleted-O', 'rats-O', 'plasma-O', 'renin-O', 'activity-O', '(-O', 'PRA-O', ')-O', 'and-O', 'systolic-O', 'blood-O', 'pressure-O', 'fell-O', 'significantly-O', 'within-O', 'four-O', 'hours-O', '.-O']
['In-O', 'sodium-B-Chemical', 'repleted-O', 'animals-O', 'indomethacin-B-Chemical', 'did-O', 'not-O', 'change-O', 'systolic-O', 'blood-O', 'pressure-O', '(-O', 'BP-O', ')-O', 'although-O', 'plasma-O', 'renin-B-Chemical', 'activity-O', 'was-O', 'decreased-O', '.-O']
['Thus-O', ',-O', 'indomethacin-B-Chemical', 'by-O', 'inhibition-O', 'of-O', 'prostaglandin-B-Chemical', 'synthesis-O', 'may-O', 'diminish-O', 'the-O', 'blood-O', 'pressure-O', 'maintaining-O', 'effect-O', 'of-O', 'the-O', 'stimulated-O', 'renin-O', ',-O', 'angiotensin-B-Chemical', 'system-O', 'in-O', 'sodium-O']
['Late-O', ',-O', 'onset-O', 'scleroderma-B-Disease', 'renal-O', 'crisis-B-Disease', 'induced-O', 'by-O', 'tacrolimus-B-Chemical', 'and-O', 'prednisolone-B-Chemical', ':-O', 'a-O', 'case-O', 'report-O', '.-O']
['Scleroderma-B-Disease', 'renal-O', 'crisis-B-Disease', '(-O', 'SRC-B-Disease', ')-O', 'is-O', 'a-O', 'rare-O', 'complication-O', 'of-O', 'systemic-O', 'sclerosis-B-Disease', '(-O', 'SSc-B-Disease', ')-O', 'but-O', 'can-O', 'be-O', 'severe-O', 'enough-O', 'to-O', 'require-O', 'temporary-O', 'or-O', 'permanent-O', 'renal-O', 'replacement-O', 'therapy-O', '.-O']
['Moderate-O', 'to-O', 'high-O', 'dose-O', 'corticosteroid-B-Chemical', 'use-O', 'is-O', 'recognized-O', 'as-O', 'a-O', 'major-O', 'risk-O', 'factor-O', 'for-O', 'SRC-B-Disease', '.-O']
['Furthermore-O', ',-O', 'there-O', 'have-O', 'been-O', 'reports-O', 'of-O', 'thrombotic-B-Disease', 'microangiopathy-I-Disease', 'precipitated-O', 'by-O', 'cyclosporine-B-Chemical', 'in-O', 'patients-O', 'with-O', 'SSc-B-Disease', '.-O']
['In-O', 'this-O', 'article-O', ',-O', 'we-O', 'report-O', 'a-O', 'patient-O', 'with-O', 'SRC-B-Disease', 'induced-O', 'by-O', 'tacrolimus-B-Chemical', 'and-O', 'corticosteroids-B-Chemical', '.-O']
['The-O', 'aim-O', 'of-O', 'this-O', 'work-O', 'is-O', 'to-O', 'call-O', 'attention-O', 'to-O', 'the-O', 'risk-O', 'of-O', 'tacrolimus-B-Chemical', 'use-O', 'in-O', 'patients-O', 'with-O', 'SSc-B-Disease']
['The-O', 'risk-O', 'and-O', 'associated-O', 'factors-O', 'of-O', 'methamphetamine-B-Chemical', 'psychosis-B-Disease', 'in-O', 'methamphetamine-B-Chemical', ',-O', 'dependent-O', 'patients-O', 'in-O', 'Malaysia-O', '.-O']
['OBJECTIVE-O', ':-O', 'The-O', 'objective-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'determine-O', 'the-O', 'risk-O', 'of-O', 'lifetime-O', 'and-O', 'current-O', 'methamphetamine-B-Chemical', ',-O', 'induced-O', 'psychosis-B-Disease', 'in-O', 'patients-O', 'with-O', 'methamphetamine-B-Chemical', 'dependence-B-Disease', '.-O']
['The-O', 'association-O', 'between-O', 'psychiatric-O', 'co-O', ',-O', 'morbidity-O', 'and-O', 'methamphetamine-B-Chemical', ',-O', 'induced-O', 'psychosis-B-Disease', 'was-O', 'also-O', 'studied-O', '.-O']
['METHODS-O', ':-O', 'This-O', 'was-O', 'a-O', 'cross-O', ',-O', 'sectional-O', 'study-O', 'conducted-O', 'concurrently-O', 'at-O', 'a-O', 'teaching-O', 'hospital-O', 'and-O', 'a-O', 'drug-O', 'rehabilitation-O', 'center-O', 'in-O', 'Malaysia-O', '.-O']
['Patients-O', 'with-O', 'the-O', 'diagnosis-O', 'of-O', 'methamphetamine-B-Chemical', 'based-O', 'on-O', 'DSM-O', ',-O', 'IV-O', 'were-O', 'interviewed-O', 'using-O', 'the-O', 'Mini-O', 'International-O', 'Neuropsychiatric-O', 'Interview-O', '(-O', 'M-O', '.-O']
['I-O', '.-O']
['N-O', '.-O']
['I-O', ')-O', 'for-O', 'methamphetamine-B-Chemical', ',-O', 'induced-O', 'psychosis-B-Disease', 'and-O', 'other-O', 'Axis-O', 'I-O', 'psychiatric-B-Disease', 'disorders-I-Disease', '.-O']
['The-O', 'information-O', 'on-O', 'sociodemographic-O', 'background-O', 'and-O', 'drug-O', 'use-O', 'history-O', 'was-O', 'obtained-O', 'from-O', 'interview-O', 'or-O', 'medical-O', 'records-O', '.-O']
['RESULTS-O', ':-O', 'Of-O', '292-O', 'subjects-O', ',-O', '47-O', '.-O']
['9-O', '%-O', 'of-O', 'the-O', 'subjects-O', 'had-O', 'a-O', 'past-O', 'history-O', 'of-O', 'psychotic-B-Disease', 'symptoms-O', 'and-O', '13-O', '.-O']
['0-O', '%-O', 'of-O', 'the-O', 'patients-O', 'were-O', 'having-O', 'current-O', 'psychotic-B-Disease', 'symptoms-O', '.-O']
['Co-O', ',-O', 'morbid-O', 'major-B-Disease', 'depressive-B-Disease', 'disorder-I-Disease', '(-O', 'OR-O', '=', '7-O', '.-O']
['18-O', ',-O', '95-O', 'CI-O', '=', '2-O', '.-O']
['612-O', ',-O', '19-O', '.-O']
['708-O', ')-O', 'bipolar-B-Disease', 'disorder-I-Disease', '(-O', 'OR-O', '=O', '13-O', '.-O']
['807-O', ',-O', '95-O', 'CI-O', '=-O', '5-O', '.-O']
['194-O', ',-O', '36-O', '.-O']
['706-O', ')-O', 'antisocial-B-Disease', 'personality-I-Disease', 'disorder-I-Disease', '(-O', 'OR-O', '=-O', '12-O', '.-O']
['619-O', ',-O', '95-O', 'CI-O', '=', '6-O', '.-O']
['702-O', ',-O', '23-O', '.-O']
['759-O', ')-O', 'and-O', 'heavy-O', 'methamphetamine-B-Chemical', 'uses-O', 'were-O', 'significantly-O', 'associated-O', 'with-O', 'lifetime-O', 'methamphetamine-B-Chemical', ',-O', 'induced-O', 'psychosis-B-Disease', 'after-O', 'adjusted-O', 'for-O', 'other-O', 'factors-O', '.-O']
['Major-B-Disease', 'depressive-B-Disease', 'disorder-I-Disease', '(-O', 'OR-O', '=-O', '2-O', '.-O']
['870-O', ',-O', 'CI-O', '=', '1-O', '.-O']
['154-O', ',-O', '7-O', '.-O']
['142-O', ')-O', 'and-O', 'antisocial-B-Disease', 'personality-I-Disease', 'disorder-I-Disease', '(-O', 'OR-O', '=-O', '3-O', '.-O']
['299-O', ',-O', '95-O', 'CI-O', '=', '1-O', '.-O']
['375-O', ',-O', '7-O', '.-O']
['914-O', ')-O', 'were-O', 'the-O', 'only-O', 'factors-O', 'associated-O', 'with-O', 'current-O', 'psychosis-B-Disease', '.-O']
['CONCLUSION-O', ':-O', 'There-O', 'was-O', 'a-O', 'high-O', 'risk-O', 'of-O', 'psychosis-B-Disease', 'in-O', 'patients-O', 'with-O', 'methamphetamine-B-Chemical', 'dependence-I-Disease', '.-O']
['It-O', 'was-O', 'associated-O', 'with-O', 'co-O', ',-O', 'morbid-O', 'affective-B-Disease', 'disorder-I-Disease', ',-O', 'antisocial-O', 'personality-O', ',-O', 'and-O', 'heavy-O', 'methamphetamine-B-Chemical', 'use-O', '.-O']
['It-O', 'is-O', 'recommended-O', 'that-O', 'all-O', 'cases-O', 'of-O', 'methamphetamine-B-Chemical', 'dependence-O', 'should-O', 'be-O', 'screened-O', 'for-O', 'psychotic-B-Disease', 'symptoms-O']
['Cerebellar-O', 'sensory-O', 'processing-O', 'alterations-O', 'impact-O', 'motor-O', 'cortical-O', 'plasticity-O', 'in-O', 'Parkinson-B-Disease', 'disease-I-Disease', ':-O', 'clues-O', 'from-O', 'dyskinetic-B-Disease', 'patients-O', '.-O']
['The-O', 'plasticity-O', 'of-O', 'primary-O', 'motor-O', 'cortex-O', '(-O', 'M1-O', ')-O', 'in-O', 'patients-O', 'with-O', 'Parkinson-B-Disease', 'disease-I-Disease', '(-O', 'PD-B-Disease', ')-O', 'and-O', 'levodopa-B-Chemical', ',-O', 'induced-O', 'dyskinesias-B-Disease', '(-O', 'LIDs-B-Disease', ')-O', 'is-O', 'severely-O', 'impaired-O', '.-O']
['We-O', 'recently-O', 'reported-O', 'in-O', 'young-O', 'healthy-O', 'subjects-O', 'that-O', 'inhibitory-O', 'cerebellar-O', 'stimulation-O', 'enhanced-O', 'the-O', 'sensorimotor-O', 'plasticity-O', 'of-O', 'M1-O', 'that-O', 'was-O', 'induced-O', 'by-O', 'paired-O', 'associative-O', 'stimulation-O', '(-O', 'PAS-O', ').-O', 'This-O', 'study-O', 'demonstrates-O', 'that-O', 'the-O', 'deficient-O', 'sensorimotor-O', 'M1-O', 'plasticity-O', 'in-O', '16-O', 'patients-O', 'with-O', 'LIDs-B-Disease', 'could-O', 'be-O', 'reinstated-O', 'by-O', 'a-O', 'single-O', 'session-O', 'of-O', 'real-O', 'inhibitory-O', 'cerebellar-O', 'stimulation-O', 'but-O', 'not-O', 'sham-O', 'stimulation-O', '.-O']
['This-O', 'was-O', 'evident-O', 'only-O', 'when-O', 'a-O', 'sensory-O', 'component-O', 'was-O', 'involved-O', 'in-O', 'the-O', 'induction-O', 'of-O', 'plasticity-O', ',-O', 'indicating-O', 'that-O', 'cerebellar-O', 'sensory-O', 'processing-O', 'function-O', 'is-O', 'involved-O', 'in-O', 'the-O', 'resurgence-O', 'of-O', 'M1-O', 'plasticity-O', '.-O']
['The-O', 'benefit-O', 'of-O', 'inhibitory-O', 'cerebellar-O', 'stimulation-O', 'on-O', 'LIDs-B-Disease', 'is-O', 'known-O', '.-O']
['To-O', 'explore-O', 'whether-O', 'this-O', 'benefit-O', 'is-O', 'linked-O', 'to-O', 'the-O', 'restoration-O', 'of-O', 'sensorimotor-O', 'plasticity-O', 'of-O', 'M1-O', ',-O', 'we-O', 'conducted-O', 'an-O', 'additional-O', 'study-O', 'looking-O', 'at-O', 'changes-O', 'in-O', 'LIDs-B-Disease', 'and-O', 'PAS-O', ',-O', 'induced-O', 'plasticity-O', 'after-O', '10-O', 'sessions-O', 'of-O', 'either-O', 'bilateral-O', ',-O', 'real-O', 'inhibitory-O', 'cerebellar-O', 'stimulation-O', 'or-O', 'sham-O', 'stimulation-O', '.-O']
['Only-O', 'real-O', 'and-O', 'not-O', 'sham-O', 'stimulation-O', 'had-O', 'an-O', 'antidyskinetic-O', 'effect-O', 'and-O', 'it-O', 'was-O', 'paralleled-O', 'by-O', 'a-O', 'resurgence-O', 'in-O', 'the-O', 'sensorimotor-O', 'plasticity-O', 'of-O', 'M1-O', '.-O']
['These-O', 'results-O', 'suggest-O', 'that-O', 'alterations-O', 'in-O', 'cerebellar-O', 'sensory-O', 'processing-O', 'function-O', ',-O', 'occurring-O', 'secondary-O', 'to-O', 'abnormal-O', 'basal-O', 'ganglia-O', 'signals-O', 'reaching-O', 'it-O', ',-O', 'may-O', 'be-O', 'an-O', 'important-O', 'element-O', 'contributing-O', 'to-O', 'the-O', 'maladaptive-O', 'sensorimotor-O', 'plasticity-O', 'of-O', 'M1-O', 'and-O', 'the-O', 'emergence-O', 'of-O', 'abnormal-O', 'involuntary-O', 'movements-I-Disease', '.-O']
['The-O', 'function-O', 'of-O', 'P2X3-O', 'receptor-O', 'and-O', 'NK1-O', 'receptor-O', 'antagonists-O', 'on-O', 'cyclophosphamide-B-Chemical', ',-O', 'induced-O', 'cystitis-B-Disease', 'in-O', 'rats-O', '.-O']
['PURPOSE-O', ':-O', 'The-O', 'purpose-O', 'of-O', 'the-O', 'study-O', 'is-O', 'to-O', 'explore-O', 'the-O', 'function-O', 'of-O', 'P2X3-O', 'and-O', 'NK1-O', 'receptors-O', 'antagonists-O', 'on-O', 'cyclophosphamide-B-Chemical', '(-O', 'CYP-O', ')-O', 'induced-O', 'cystitis-B-Disease', 'in-O', 'rats-O', '.-O']
['METHODS-O', ':-O', 'Sixty-O', 'female-O', 'Sprague-O', ',-O', 'Dawley-O', '(-O', 'SD-O', ')-O', 'rats-O', 'were-O', 'randomly-O', 'divided-O', 'into-O', 'three-O', 'groups-O', '.-O']
['The-O', 'rats-O', 'in-O', 'the-O', 'control-O', 'group-O', 'were-O', 'intraperitoneally-O', '(-O', 'i-O', '.-O']
['p-O', ')-O', 'injected-O', 'with-O', '0-O', '.-O']
['9-O', '%-O', 'saline-O', '(-O', '4-O', 'ml-O', '/-O', 'kg-O', ');-O', 'the-O', 'rats-O', 'in-O', 'the-O', 'model-O', 'group-O', 'were-O', 'i-O', '.-O']
['p-O', '.-O']
['injected-O', 'with-O', 'CYP-B-Chemical', '(-O', '150-O', 'mg-O', '/-O', 'kg-O', ')-O', ';-O', 'and-O', 'the-O', 'rats-O', 'in-O', 'the-O', 'intervention-O', 'group-O', 'were-O', 'i-O', '.-O']
['p-O', '.-O']
['injected-O', 'with-O', 'CYP-O', 'with-O', 'subsequently-O', 'perfusion-O', 'of-O', 'bladder-O', 'with-O', 'P2X3-O', 'and-O', 'NK1-O', 'receptors-O', 'x-O', 'antagonists-O', ',-O', 'Suramin-B-Chemical', 'and-O', 'GR-B-Chemical', '82334-I-Chemical', '.-O']
['Spontaneous-O', 'pain-B-Disease', 'behaviors-O', 'following-O', 'the-O', 'administration-O', 'of-O', 'CYP-B-Chemical', 'were-O', 'observed-O', '.-O']
['Urodynamic-O', 'parameters-O', ',-O', 'bladder-O', 'pressure-O', ',-O', 'volume-O', 'curve-O', ',-O', 'maximum-O', 'voiding-O', 'pressure-O', '(-O', 'MVP-O', ')-O', ',', 'and-O', 'maximum-O', 'cystometric-O', 'capacity-O', '(-O', 'MCC-O', ')-O', ',', 'were-O', 'recorded-O', '.-O']
['Pathological-O', 'changes-O', 'in-O', 'bladder-B-Disease', 'tissue-O', 'were-O', 'observed-O', '.-O']
['Immunofluorescence-O', 'was-O', 'used-O', 'to-O', 'detect-O', 'the-O', 'expression-O', 'of-O', 'P2X3-O', 'and-O', 'NK1-O', 'receptors-O', 'in-O', 'bladder-O', '.-O']
['RESULTS-O', ':-O', 'Cyclophosphamide-B-Chemical', 'treatment-O', 'increased-O', 'the-O', 'spontaneous-O', 'pain-B-Disease', 'behaviors-O', 'scores-O', '.-O']
['The-O', 'incidence-O', 'of-O', 'bladder-O', 'instability-B-Disease', 'during-O', 'urine-O', 'storage-O', 'period-O', 'of-O', 'model-O', 'group-O', 'was-O', 'significantly-O', 'higher-O', 'than-O', 'intervention-O', 'group-O', '(-O', 'X-O', '(-O', '2-O', ')-O', '7-O', '.-O']
['619-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['007-O', ')-O', 'and-O', 'control-O', 'group-O', '(-O', 'X-O', '(-O', '2-O', ')-O', '13-O', '.-O']
['755-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['000-O', ').-O', 'MCC-O', 'in-O', 'the-O', 'model-O', 'group-O', 'was-O', 'lower-O', 'than-O', 'the-O', 'control-O', 'and-O', 'intervention-O', 'groups-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'Histological-O', 'changes-O', 'evident-O', 'in-O', 'model-O', 'and-O', 'intervention-O', 'groups-O', 'rats-O', 'x-O', 'bladder-O', 'included-O', 'edema-I-Disease', ',-O', 'vasodilation-I-Disease', ',-O', 'and-O', 'infiltration-O', 'of-O', 'inflammatory-O', 'cells-O', '.-O']
['In-O', 'model-O', 'group-O', ',-O', 'the-O', 'expression-O', 'of-O', 'P2X3-O', 'receptor-O', 'increased-O', 'in-O', 'urothelium-O', 'and-O', 'suburothelium-O', ',-O', 'and-O', 'NK1-O', 'receptor-O', 'increased-O', 'in-O', 'suburothelium-O', ',-O', 'while-O', 'the-O', 'expression-O', 'of-O', 'them-O', 'in-O', 'intervention-O', 'group-O', 'was-O', 'lower-O', '.-O']
['CONCLUSIONS-O', ':-O', 'In-O', 'CYP-O', ',-O', 'induced-O', 'cystitis-B-Disease']
['Acute-B-Disease', 'hepatitis-I-Disease', 'associated-O', 'with-O', 'clopidogrel-B-Chemical', ':-O', 'a-O', 'case-O', 'report-O', 'and-O', 'review-O', 'of-O', 'the-O', 'literature-O', '.-O']
['Drug-O', ',-O', 'induced-O', 'hepatotoxicity-B-Disease', 'is-O', 'a-O', 'common-O', 'cause-O', 'of-O', 'acute-O', 'hepatitis-B-Disease', ',-O', 'and-O', 'the-O', 'recognition-O', 'of-O', 'the-O', 'responsible-O', 'drug-O', 'may-O', 'be-O', 'difficult-O', '.-O']
['We-O', 'describe-O', 'a-O', 'case-O', 'of-O', 'clopidogrel-B-Chemical', ',-O', 'related-O', 'acute-O', 'hepatitis-B-Disease', '.-O']
['The-O', 'diagnosis-O', 'is-O', 'strongly-O', 'suggested-O', 'by-O', 'an-O', 'accurate-O', 'medical-O', 'history-O', 'and-O', 'liver-O', 'biopsy-O', '.-O']
['Reports-O', 'about-O', 'cases-O', 'of-O', 'hepatotoxicity-B-Disease', 'due-O', 'to-O', 'clopidogrel-B-Chemical', 'are-O', 'increasing-O', 'in-O', 'the-O', 'last-O', 'few-O', 'years-O', ',-O', 'after-O', 'the-O', 'increased-O', 'use-O', 'of-O', 'this-O', 'drug-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'we-O', 'believe-O', 'that-O', 'physicians-O', 'should-O', 'carefully-O', 'consider-O', 'the-O', 'risk-O', 'of-O', 'drug-O', ',-O', 'induced-O', 'hepatic-B-Disease', 'injury-I-Disease', 'when-O', 'clopidogrel-B-Chemical']
['Bortezomib-B-Chemical', 'and-O', 'dexamethasone-B-Chemical', 'as-O', 'salvage-O', 'therapy-O', 'in-O', 'patients-O', 'with-O', 'relapsed-O', '/-O', 'refractory-O', 'multiple-B-Disease', 'myeloma-I-Disease', ':-O', 'analysis-O', 'of-O', 'long-O', '-O', 'term-O', 'clinical-O', 'outcomes-O', '.-O']
['Bortezomib-B-Chemical', '(-O', 'bort-B-Chemical', ')-O', 'dexamethasone-B-Chemical', '(-O', 'dex-B-Chemical', ')-O', 'is-O', 'an-O', 'effective-O', 'therapy-O', 'for-O', 'relapsed-O', '/-O', 'refractory-O', '(-O', 'R-O', '/-O', 'R-O', ')-O', 'multiple-O', 'myeloma-B-Disease', '(-O', 'MM-B-Disease', ').-O', 'This-O', 'retrospective-O', 'study-O', 'investigated-O', 'the-O', 'combination-O', 'of-O', 'bort-B-Chemical', '(-O', '1-O', '.-O']
['3-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'on-O', 'days-O', '1-O', ',-O', '4-O', ',-O', '8-O', ',-O', 'and-O', '11-O', 'every-O', '3-O', 'weeks-O', ')-O', 'and-O', 'dex-B-Chemical', '(-O', '20-O', 'mg-O', 'on-O', 'the-O', 'day-O', 'of-O', 'and-O', 'the-O', 'day-O', 'after-O', 'bort-O', ')-O', 'as-O', 'salvage-O', 'treatment-O', 'in-O', '85-O', 'patients-O', 'with-O', 'R-O', '/-O', 'R-O', 'MM-B-Disease', 'after-O', 'prior-O', 'autologous-O', 'stem-O', 'cell-O', 'transplantation-O', 'or-O', 'conventional-O', 'chemotherapy-O', '.-O']
['The-O', 'median-O', 'number-O', 'of-O', 'prior-O', 'lines-O', 'of-O', 'therapy-O', 'was-O', '2-O', '.-O']
['Eighty-O', ',-O', 'seven-O', 'percent-O', 'of-O', 'the-O', 'patients-O', 'had-O', 'received-O', 'immunomodulatory-O', 'drugs-O', 'included-O', 'in-O', 'some-O', 'line-O', 'of-O', 'therapy-O', 'before-O', 'bort-B-Chemical', ',-O', 'dex-B-Chemical', '.-O']
['The-O', 'median-O', 'number-O', 'of-O', 'bort-B-Chemical', ',-O', 'dex-B-Chemical', 'cycles-O', 'was-O', '6-O', ',-O', 'up-O', 'to-O', 'a-O', 'maximum-O', 'of-O', '12-O', 'cycles-O', '.-O']
['On-O', 'an-O', 'intention-O', ',-O', 'to-O', ',-O', 'treat-O', 'basis-O', ',-O', '55-O', '%-O', 'of-O', 'the-O', 'patients-O', 'achieved-O', 'at-O', 'least-O', 'partial-O', 'response-O', ',-O', 'including-O', '19-O', '%-O', 'CR-O', 'and-O', '35-O', '%-O', 'achieved-O', 'at-O', 'least-O', 'very-O', 'good-O', 'partial-O', 'response-O', '.-O']
['Median-O', 'durations-O', 'of-O', 'response-O', ',-O', 'time-O', 'to-O', 'next-O', 'therapy-O', 'and-O', 'treatment-O', ',-O', 'free-O', 'interval-O', 'were-O', '8-O', ',-O', '11-O', '.-O']
['2-O', ',-O', 'and-O', '5-O', '.-O']
['1-O', 'months-O', ',-O', 'respectively-O', '.-O']
['The-O', 'most-O', 'relevant-O', 'adverse-O', 'event-O', 'was-O', 'peripheral-B-Disease', 'neuropathy-B-Disease', ',-O', 'which-O', 'occurred-O', 'in-O', '78-O', '%-O', 'of-O', 'the-O', 'patients-O', '(-O', 'grade-O', 'II-O', ',-O', '38-O', ';-O', 'grade-O', 'III-O', ',-O', '21-O', ')-O', 'and-O', 'led-O', 'to-O', 'treatment-O', 'discontinuation-O', 'in-O', '6-O', '.-O', 'With-O', 'a-O', 'median-O', 'follow-O', 'up-O', 'of-O', '22-O', 'months-O', ',-O', 'median-O', 'time-O', 'to-O', 'progression-O', ',-O', 'progression-O', ',-O', 'free-O', 'survival-O', '(-O', 'PFS-O', ')-O', 'and-O', 'overall-O', 'survival-O', '(-O', 'OS-O', ')-O', 'were-O', '8-O', '.-O']
['9-O', ',-O', '8-O', '.-O']
['7-O', ',-O', 'and-O', '22-O', 'months-O', ',-O', 'respectively-O', '.-O']
['Prolonged-O', 'PFS-O', 'and-O', 'OS-O', 'were-O', 'observed-O', 'in-O', 'patients-O', 'achieving-O', 'CR-O', 'and-O', 'receiving-O', 'bort-B-Chemical', ',-O', 'dex-B-Chemical', 'a-O', 'single-O', 'line-O', 'of-O', 'prior-O', 'therapy-O', '.-O']
['Bort-B-Chemical', ',-O', 'dex-B-Chemical', 'was-O', 'an-O', 'effective-O', 'salvage-O', 'treatment-O', 'for-O', 'MM-B-Disease']
['Pubertal-O', 'exposure-O', 'to-O', 'Bisphenol-O', 'A-B-Chemical', 'increases-O', 'anxiety-B-Disease', ',-O', 'like-O', 'behavior-O', 'and-O', 'decreases-O', 'acetylcholinesterase-O', 'activity-O', 'of-O', 'hippocampus-O', 'in-O', 'adult-O', 'male-O', 'mice-O', '.-O']
['The-O', 'negative-O', 'effects-O', 'of-O', 'Bisphenol-O', 'A-O', '(-O', 'BPA-B-Chemical', ')-O', 'on-O', 'neurodevelopment-O', 'and-O', 'behaviors-O', 'have-O', 'been-O', 'well-O', 'established-O', '.-O']
['Acetylcholinesterase-O', '(', 'AChE-O', ')-O', 'is-O', 'a-O', 'regulatory-O', 'enzyme-O', 'which-O', 'is-O', 'involved-O', 'in-O', 'anxiety-B-Disease', ',-O', 'like-O', 'behavior-O', '.-O']
['This-O', 'study-O', 'investigated-O', 'behavioral-O', 'phenotypes-O', 'and-O', 'AChE-O', 'activity-O', 'in-O', 'male-O', 'mice-O', 'following-O', 'BPA-B-Chemical', 'exposure-O', 'during-O', 'puberty-O', '.-O']
['On-O', 'postnatal-O', 'day-O', '(-O', 'PND-O', ')-O', '35-O', ',-O', 'male-O', 'mice-O', 'were-O', 'exposed-O', 'to-O', '50mg-O', 'BPA-B-Chemical', '/-O', 'kg-O', 'diet-O', 'per-O', 'day-O', 'for-O', 'a-O', 'period-O', 'of-O', '35-O', 'days-O', '.-O']
['On-O', 'PND71-O', ',-O', 'a-O', 'behavioral-O', 'assay-O', 'was-O', 'performed-O', 'using-O', 'the-O', 'elevated-O', 'plus-O', 'maze-O', '(-O', 'EPM-O', ')-O', 'and-O', 'the-O', 'light-O', '/-O', 'dark-O', 'test-O', '.-O']
['In-O', 'addition-O', ',-O', 'AChE-O', 'activity-O', 'was-O', 'measured-O', 'in-O', 'the-O', 'prefrontal-O', 'cortex-O', ',-O', 'hypothalamus-O', ',-O', 'cerebellum-O', 'and-O', 'hippocampus-O', '.-O']
['Results-O', 'from-O', 'our-O', 'behavioral-O', 'phenotyping-O', 'indicated-O', 'that-O', 'anxiety-B-Disease', ',-O', 'like-O', 'behavior-O', 'was-O', 'increased-O', 'in-O', 'mice-O', 'exposed-O', 'to-O', 'BPA-B-Chemical', '.-O']
['AChE-O', 'activity-O', 'was-O', 'significantly-O', 'decreased-O', 'in-O', 'the-O', 'hippocampus-O', 'of-O', 'mice-O', 'with-O', 'BPA-B-Chemical', 'compared-O', 'to-O', 'control-O', 'mice-O', ',-O', 'whereas-O', 'no-O', 'difference-O', 'was-O', 'found-O', 'in-O', 'the-O', 'prefrontal-O', 'cortex-O', ',-O', 'hypothalamus-O', 'and-O', 'cerebellum-O', '.-O']
['Our-O', 'findings-O', 'showed-O', 'that-O', 'pubertal-O', 'BPA-B-Chemical', 'exposure-O', 'increased-O', 'anxiety-B-Disease', ',-O', 'like-O', 'behavior-O', ',-O', 'which-O', 'may-O', 'be-O', 'associated-O', 'with-O', 'decreased-O', 'AChE-O', 'activity-O', 'of-O', 'the-O', 'hippocampus-O', 'in-O', 'adult-O', 'male-O', 'mice-O', '.-O']
['Further-O', 'studies-O', 'are-O', 'necessary-O', 'to-O', 'investigate-O', 'the-O', 'cholinergic-O', 'signaling-O', 'of-O', 'the-O', 'hippocampus-O', 'in-O', 'PBE-O', 'induced-O', 'anxiety-B-Disease']
['Biochemical-O', 'effects-O', 'of-O', 'Solidago-B-Chemical', 'virgaurea-I-Chemical', 'extract-I-Chemical', 'on-O', 'experimental-O', 'cardiotoxicity-B-Disease', '.-O']
['Cardiovascular-B-Disease', 'diseases-I-Disease', '(-O', 'CVDs-B-Disease', ')-O', 'are-O', 'the-O', 'major-O', 'health-O', 'problem-O', 'of-O', 'advanced-O', 'as-O', 'well-O', 'as-O', 'developing-O', 'countries-O', 'of-O', 'the-O', 'world-O', '.-O']
['The-O', 'aim-O', 'of-O', 'the-O', 'present-O', 'study-O', 'was-O', 'to-O', 'investigate-O', 'the-O', 'protective-O', 'effect-O', 'of-O', 'the-O', 'Solidago-O', 'virgaurea-O', 'extract-O', 'on-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', 'in-O', 'rats-O', '.-O']
['The-O', 'subcutaneous-O', 'injection-O', 'of-O', 'isoproterenol-B-Chemical', '(-O', '30-O', 'mg-O', '/-O', 'kg-O', ')-O', 'into-O', 'rats-O', 'twice-O', 'at-O', 'an-O', 'interval-O', 'of-O', '24-O', 'h-O', ',-O', 'for-O', 'two-O', 'consecutive-O', 'days-O', ',-O', 'led-O', 'to-O', 'a-O', 'significant-O', 'increase-O', 'in-O', 'serum-O', 'lactate-B-Chemical', 'dehydrogenase-O', ',-O', 'creatine-B-Chemical', 'phosphokinase-O', ',-O', 'alanine-B-Chemical', 'transaminase-O', ',-O', 'aspartate-B-Chemical', 'transaminase-O', ',-O', 'and-O', 'angiotensin-B-Chemical', 'converting-O', 'enzyme-O', 'activities-O', ',-O', 'total-O', 'cholesterol-B-Chemical', ',-O', 'triglycerides-O', ',-O', 'free-O', 'serum-O', 'fatty-O', 'acid-O', ',-O', 'cardiac-O', 'tissue-O', 'malondialdehyde-B-Chemical', '(-O', 'MDA-O', ')-O', 'and-O', 'nitric-O', 'oxide-B-Chemical', 'levels-O', 'and-O', 'a-O', 'significant-O', 'decrease-O', 'in-O', 'levels-O', 'of-O', 'glutathione-B-Chemical', 'and-O', 'superoxide-B-Chemical', 'dismutase-O', 'in-O', 'cardiac-O', 'tissue-O', 'as-O', 'compared-O', 'to-O', 'the-O', 'normal-O', 'control-O', 'group-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'Pretreatment-O', 'with-O', 'S-B-Chemical']
['virgaurea-B-Chemical', 'extract-I-Chemical', 'for-O', '5-O', 'weeks-O', 'at-O', 'a-O', 'dose-O', 'of-O', '250-O', 'mg-O', '/-O', 'kg-O', 'followed-O', 'by-O', 'isoproterenol-B-Chemical', 'injection-O', 'significantly-O', 'prevented-O', 'the-O', 'observed-O', 'alterations-O', '.-O']
['Captopril-B-Chemical', '(-O', '50-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', ',-O', 'given-O', 'orally-O', ')-O', 'an-O', 'inhibitor-O', 'of-O', 'angiotensin-B-Chemical', ',-O', 'converting-O', 'enzyme-O', 'used-O', 'as-O', 'a-O', 'standard-O', 'cardioprotective-O', 'drug-O', ',-O', 'was-O', 'used-O', 'as-O', 'a-O', 'positive-O', 'control-O', 'in-O', 'this-O', 'study-O', '.-O']
['The-O', 'data-O', 'of-O', 'the-O', 'present-O', 'study-O', 'suggest-O', 'that-O', 'S-B-Chemical']
['virgaurea-B-Chemical', 'extract-I-Chemical', 'exerts-O', 'its-O', 'protective-O', 'effect-O', 'by-O', 'decreasing-O', 'MDA-B-Chemical', 'level-O', 'and-O', 'increasing-O', 'the-O', 'antioxidant-O', 'status-O', 'in-O', 'isoproterenol-B-Chemical']
['x-O', 'Real-O', ',-O', 'world-O', 'x-O', 'data-O', 'on-O', 'the-O', 'efficacy-O', 'and-O', 'safety-O', 'of-O', 'lenalidomide-B-Chemical', 'and-O', 'dexamethasone-B-Chemical', 'in-O', 'patients-O', 'with-O', 'relapsed-O', '/-O', 'refractory-O', 'multiple-O', 'myeloma-B-Disease', 'who-O', 'were-O', 'treated-O', 'according-O', 'to-O', 'the-O', 'standard-O', 'clinical-O', 'practice-O', ':-O', 'a-O', 'study-O', 'of-O', 'the-O', 'Greek-O', 'Myeloma-O', 'Study-O', 'Group-O', '.-O']
['Lenalidomide-B-Chemical', 'and-O', 'dexamethasone-B-Chemical', '(-O', 'RD-O', ')-O', 'is-O', 'a-O', 'standard-O', 'of-O', 'care-O', 'for-O', 'relapsed-O', '/-O', 'refractory-O', 'multiple-O', 'myeloma-I-Disease', '(-O', 'RRMM-O', ')-O', ',', 'but-O', 'there-O', 'is-O', 'limited-O', 'published-O', 'data-O', 'on-O', 'its-O', 'efficacy-O', 'and-O', 'safety-O', 'in-O', 'the-O', 'x-O', 'real-O', 'world-O', '(-O', 'RW-O', ')-O', ',', 'according-O', 'to-O', 'the-O', 'International-O', 'Society-O', 'of-O', 'Pharmacoeconomics-O', 'and-O', 'Outcomes-O', 'Research-O', 'definition-O', '.-O']
['We-O', 'studied-O', '212-O', 'RRMM-B-Disease', 'patients-O', 'who-O', 'received-O', 'RD-O', 'in-O', 'RW-O', '.-O']
['Objective-O', 'response-O', '(>-O', 'PR-O', '(-O', 'partial-O', 'response-O', '))-O', 'rate-O', 'was-O', '77-O', '.-O']
['4-O', '(-O', 'complete-O', 'response-O', '(-O', 'CR-O', ')-O', '20-O', '.-O']
['2-O', ').-O', 'Median-O', 'time-O', 'to-O', 'first-O', 'and-O', 'best-O', 'response-O', 'was-O', '2-O', 'and-O', '5-O', 'months-O', ',-O', 'respectively-O', '.-O']
['Median-O', 'time-O', 'to-O', 'CR-O', 'when-O', 'RD-O', 'was-O', 'given-O', 'as-O', '2nd-O', 'or-O', '>-O', '2-O', '(-O', 'nd-O', ')-O', 'line-O', 'treatment-O', 'at-O', '4-O', 'and-O', '11-O', 'months-O', ',-O', 'respectively-O', '.-O']
['Quality-O', 'of-O', 'response-O', 'was-O', 'independent-O', 'of-O', 'previous-O', 'lines-O', 'of-O', 'therapies-O', 'or-O', 'previous-O', 'exposure-O', 'to-O', 'thalidomide-B-Chemical', 'or-O', 'bortezomib-B-Chemical', '.-O']
['Median-O', 'duration-O', 'of-O', 'response-O', 'was-O', '34-O', '.-O']
['4-O', 'months-O', ',-O', 'and-O', 'it-O', 'was-O', 'higher-O', 'in-O', 'patients-O', 'who-O', 'received-O', 'RD-O', 'until-O', 'progression-O', '(-O', 'not-O', 'reached-O', 'versus-O', '19-O', 'months-O', ',-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'Improvement-O', 'of-O', 'humoral-O', 'immunity-O', 'occurred-O', 'in-O', '60-O', '%-O', 'of-O', 'responders-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', ')-O', 'and-O', 'in-O', 'the-O', 'majority-O', 'of-O', 'patients-O', 'who-O', 'achieved-O', 'stable-O', 'disease-B-Disease', '.-O']
['Adverse-O', 'events-O', 'were-O', 'reported-O', 'in-O', '68-O', '.-O']
['9-O', '%-O', 'of-O', 'patients-O', '(-O', 'myelosuppression-B-Disease', 'in-O', '49-O', '.-O']
['4-O', ')-O', 'and-O', '12-O', '.-O']
['7-O', '%-O', 'of-O', 'patients-O', 'needed-O', 'hospitalization-B-Disease', '.-O']
['Peripheral-B-Disease', 'neuropathy-I-Disease', 'was-O', 'observed-O', 'only-O', 'in-O', '2-O', '.-O']
['5-O', '%-O', 'of-O', 'patients-O', 'and-O', 'deep-O', 'vein-I-Disease', 'thrombosis-B-Disease', 'in-O', '5-O', '.-O']
['7-O', '.-O', 'Dose-O', 'reductions-O', 'were-O', 'needed-O', 'in-O', '31-O', '%-O', 'of-O', 'patients-O', 'and-O', 'permanent-O', 'discontinuation-O', 'in-O', '38-O', '.-O']
['9-O', '.-O', 'Median-O', 'time-O', 'to-O', 'treatment-O', 'discontinuation-O', 'was-O', '16-O', '.-O']
['8-O', 'months-O', '.-O']
['Performance-O', 'status-O', '(-O', 'PS-O', ')-O', 'and-O', 'initial-O', 'lenalidomide-B-Chemical', 'dose-O', 'predicted-O', 'for-O', 'treatment-O', 'discontinuation-O', '.-O']
['Extra-O', ',-O', 'medullary-B-Disease', 'relapses-I-Disease', 'occurred-O', 'in-O', '3-O', '.-O']
['8-O', '%-O', 'of-O', 'patients-O', '.-O']
['Our-O', 'study-O', 'confirms-O', 'that-O', 'RD-B-Disease', 'is-O', 'effective-O', 'and-O', 'safe-O', 'in-O', 'RRMM-B-Disease']
['The-O', 'cytogenetic-O', 'action-O', 'of-O', 'ifosfamide-B-Chemical', ',-O', 'mesna-B-Chemical', ',-O', 'and-O', 'their-O', 'combination-O', 'on-O', 'peripheral-O', 'rabbit-O', 'lymphocytes-O', ':-O', 'an-O', 'in-O', 'vivo-O', '/-O', 'in-O', 'vitro-O', 'cytogenetic-O', 'study-O', '.-O']
['Ifosfamide-B-Chemical', '(-O', 'IFO-B-Chemical', ')-O', 'is-O', 'an-O', 'alkylating-O', 'nitrogen-O', 'mustard-O', ',-O', 'administrated-O', 'as-O', 'an-O', 'antineoplasmic-O', 'agent-O', '.-O']
['It-O', 'is-O', 'characterized-O', 'by-O', 'its-O', 'intense-O', 'urotoxic-O', 'action-O', ',-O', 'leading-O', 'to-O', 'hemorrhagic-B-Disease', 'cystitis-I-Disease', '.-O']
['This-O', 'side-O', 'effect-O', 'of-O', 'IFO-B-Chemical', 'raises-O', 'the-O', 'requirement-O', 'for-O', 'the-O', 'co-O', 'administration-O', 'with-O', 'sodium-B-Chemical', '2-sulfanylethanesulfonate-B-Chemical', '(-O', 'Mesna-B-Chemical', ')-O', 'aiming-O', 'to-O', 'avoid-O', 'or-O', 'minimize-O', 'this-O', 'effect-O', '.-O']
['IFO-B-Chemical', 'and-O', 'Mesna-B-Chemical', 'were-O', 'administrated-O', 'separately-O', 'on-O', 'rabbit-O', 'x-O', 's-O', 'lymphocytes-O', 'in-O', 'vivo-O', ',-O', 'which-O', 'were-O', 'later-O', 'developed-O', 'in-O', 'vitro-O', '.-O']
['Cytogenetic-O', 'markers-O', 'for-O', 'sister-O', 'chromatid-O', 'exchanges-O', '(-O', 'SCEs-O', '),
['Mesna-B-Chemical', 'x-O', 's-O', 'action-O', ',-O', 'in-O', 'conjunction-O', 'with-O', 'IFO-B-Chemical', 'reduces-O', 'the-O', 'frequency-O', 'of-O', 'SCEs-O', ',-O', 'in-O', 'comparison-O', 'with-O', 'the-O', 'SCEs-O', 'recordings-O', 'obtained-O', 'when-O', 'IFO-B-Chemical', 'is-O', 'administered-O', 'alone-O', '.-O']
['In-O', 'addition-O', 'to-O', 'this-O', ',-O', 'when-O', 'high-O', 'concentrations-O', 'of-O', 'Mesna-B-Chemical', 'were-O', 'administered-O', 'alone-O', 'significant-O', 'reductions-O', 'of-O', 'the-O', 'PRI-O', 'were-O', 'noted-O', ',-O', 'than-O', 'with-O', 'IFO-B-Chemical', 'acting-O', 'at-O', 'the-O', 'same-O', 'concentration-O', 'on-O', 'the-O', 'lymphocytes-O', '.-O']
['Mesna-B-Chemical', 'significantly-O', 'reduces-O', 'IFO-B-Chemical', 'x-O', 's-O', 'genotoxicity-O']
['Risk-O', 'factors-O', 'and-O', 'predictors-O', 'of-O', 'levodopa-B-Chemical', ',-O', 'induced-O', 'dyskinesia-B-Disease', 'among-O', 'multiethnic-O', 'Malaysians-O', 'with-O', 'Parkinson-B-Disease', 'disease-I-Disease', '.-O']
['Chronic-O', 'pulsatile-O', 'levodopa-B-Chemical', 'therapy-O', 'for-O', 'Parkinson-B-Disease', 'disease-I-Disease', '(-O', 'PD-B-Disease', ')-O', 'leads-O', 'to-O', 'the-O', 'development-O', 'of-O', 'motor-O', 'fluctuations-O', 'and-O', 'dyskinesia-B-Disease', '.-O']
['We-O', 'studied-O', 'the-O', 'prevalence-O', 'and-O', 'predictors-O', 'of-O', 'levodopa-B-Chemical', ',-O', 'induced-O', 'dyskinesia-B-Disease', 'among-O', 'multiethnic-O', 'Malaysian-O', 'patients-O', 'with-O', 'PD-B-Disease', '.-O']
['METHODS-O', ':-O', 'This-O', 'is-O', 'a-O', 'cross-O', ',-O', 'sectional-O', 'study-O', 'involving-O', '95-O', 'patients-O', 'with-O', 'PD-B-Disease', 'on-O', 'uninterrupted-O', 'levodopa-B-Chemical', 'therapy-O', 'for-O', 'at-O', 'least-O', '6-O', 'months-O', '.-O']
['The-O', 'instrument-O', 'used-O', 'was-O', 'the-O', 'UPDRS-B-Disease', 'questionnaires-O', '.-O']
['The-O', 'predictors-O', 'of-O', 'dyskinesia-B-Disease', 'were-O', 'determined-O', 'using-O', 'multivariate-O', 'logistic-O', 'regression-O', 'analysis-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'mean-O', 'age-O', 'was-O', '65-O', '.-O']
['6-O', '+-O', '8-O', '.-O']
['5-O', 'years-O', '.-O']
['The-O', 'mean-O', 'onset-O', 'age-O', 'was-O', '58-O', '.-O']
['5-O', '+-O', '9-O', '.-O']
['8-O', 'years-O', '.-O']
['The-O', 'median-O', 'disease-B-Disease', 'duration-O', 'was-O', '6-O', '(-O', '7-O', ')-O', 'years-O', '.-O']
['Dyskinesia-B-Disease', 'was-O', 'present-O', 'in-O', '44-O', '(-O', 'n-O', '='-O', '42-O', ')-O', 'with-O', 'median-O', 'levodopa-B-Chemical', 'therapy-O', 'of-O', '3-O', 'years-O', '.-O']
['There-O', 'were-O', '64-O', '.-O']
['3-O', '%-O', 'Chinese-O', ',-O', '31-O', '%-O', 'Malays-O', ',-O', 'and-O', '3-O', '.-O']
['7-O', '%-O', 'Indians-O', 'and-O', 'other-O', 'ethnic-O', 'groups-O', '.-O']
['Eighty-O', ',-O', 'one-O', 'percent-O', 'of-O', 'patients-O', 'with-O', 'dyskinesia-B-Disease', 'had-O', 'clinical-O', 'fluctuations-O', '.-O']
['Patients-O', 'with-O', 'dyskinesia-B-Disease', 'had-O', 'lower-O', 'onset-O', 'age-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', '),-O', 'longer-O', 'duration-O', 'of-O', 'levodopa-B-Chemical', 'therapy-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', '),-O', 'longer-O', 'disease-B-Disease', 'duration-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', '),-O', 'higher-O', 'total-O', 'daily-O', 'levodopa-B-Chemical', 'dose-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', '),-O', 'and-O', 'higher-O', 'total-O', 'UPDRS-O', 'scores-O', '(-O', 'p-O', '=-O', '0-O', '.-O']
['005-O', ')-O', 'than-O', 'patients-O', 'without-O', 'dyskinesia-B-Disease', '.-O']
['The-O', 'three-O', 'significant-O', 'predictors-O', 'of-O', 'dyskinesia-B-Disease', 'were-O', 'duration-O', 'of-O', 'levodopa-B-Chemical', 'therapy-O', ',-O', 'onset-O', 'age-O', ',-O', 'and-O', 'total-O', 'daily-O', 'levodopa-B-Chemical', 'dose-O', '.-O']
['CONCLUSIONS-O', ':-O', 'The-O', 'prevalence-O', 'of-O', 'levodopa-B-Chemical', ',-O', 'induced-O', 'dyskinesia-B-Disease', 'in-O', 'our-O', 'patients-O', 'was-O', '44-O', '.-O', 'The-O', 'most-O', 'significant-O', 'predictors-O', 'were-O', 'duration-O', 'of-O', 'levodopa-B-Chemical', 'therapy-O', ',-O', 'total-O', 'daily-O', 'levodopa-B-Chemical']
['An-O', 'unexpected-O', 'diagnosis-O', 'in-O', 'a-O', 'renal-O', ',-O', 'transplant-O', 'patient-O', 'with-O', 'proteinuria-B-Disease', 'treated-O', 'with-O', 'everolimus-B-Chemical', ':-O', 'AL-O', 'amyloidosis-B-Disease', '.-O']
['Proteinuria-B-Disease', 'is-O', 'an-O', 'expected-O', 'complication-O', 'in-O', 'transplant-O', 'patients-O', 'treated-O', 'with-O', 'mammalian-O', 'target-O', 'of-O', 'rapamycin-B-Chemical', 'inhibitors-O', '(-O', 'mTOR-O', ',', 'i-O', ').-O', 'However-O', ',', 'clinical-O', 'suspicion-O', 'should-O', 'always-O', 'be-O', 'supported-O', 'by-O', 'histological-O', 'evidence-O', 'in-O', 'order-O', 'to-O', 'investigate-O', 'potential-O', 'alternate-O', 'diagnoses-O', 'such-O', 'as-O', 'acute-O', 'or-O', 'chronic-O', 'rejection-O', ',', 'interstitial-O', 'fibrosis-O', 'and-O', 'tubular-O', 'atrophy-O', ',', 'or-O', 'recurrent-O', 'or-O', 'de-O', 'novo-O', 'glomerulopathy-B-Disease', '.-O']
['In-O', 'this-O', 'case-O', 'we-O', 'report-O', 'the-O', 'unexpected-O', 'diagnosis-O', 'of-O', 'amyloidosis-B-Disease', 'in-O', 'a-O', 'renal-O', ',-O', 'transplant-O', 'patient-O', 'with-O', 'pre-O', ',-O', 'transplant-O', 'monoclonal-O', 'gammapathy-O', 'of-O', 'undetermined-O', 'significance-O', 'who-O', 'developed-O', 'proteinuria-B-Disease', 'after-O', 'conversion-O', 'from-O', 'tacrolimus-B-Chemical', 'to-O', 'everolimus-B-Chemical']
['An-O', 'investigation-O', 'of-O', 'the-O', 'pattern-O', 'of-O', 'kidney-O', 'injury-O', 'in-O', 'HIV-O', ',-O', 'positive-O', 'persons-O', 'exposed-O', 'to-O', 'tenofovir-B-Chemical', 'disoproxil-B-Chemical', 'fumarate-B-Chemical', ':-O', 'an-O', 'examination-O', 'of-O', 'a-O', 'large-O', 'population-O', 'database-O', '(-O', 'MHRA-O', 'database-O', ').-O', 'The-O', 'potential-O', 'for-O', 'tenofovir-B-Chemical', 'to-O', 'cause-O', 'a-O', 'range-O', 'of-O', 'kidney-O', 'syndromes-O', 'has-O', 'been-O', 'established-O', 'from-O', 'mechanistic-O', 'and-O', 'randomised-O', 'clinical-O', 'trials-O', '.-O']
['However-O', ',-O', 'the-O', 'exact-O', 'pattern-O', 'of-O', 'kidney-O', 'involvement-O', 'is-O', 'still-O', 'uncertain-O', '.-O']
['We-O', 'undertook-O', 'a-O', 'descriptive-O', 'analysis-O', 'of-O', 'Yellow-O', 'Card-O', 'records-O', 'of-O', '407-O', 'HIV-B-Disease', 'positive-O', 'persons-O', 'taking-O', 'tenofovir-B-Chemical', 'disoproxil-B-Chemical', 'fumarate-B-Chemical', '(-O', 'TDF-B-Chemical', ')-O', 'as-O', 'part-O', 'of-O', 'their-O', 'antiretroviral-O', 'therapy-O', 'regimen-O', 'and-O', 'submitted-O', 'to-O', 'the-O', 'Medicines-O', 'and-O', 'Healthcare-O', 'Products-O', 'Regulatory-O', 'Agency-O', '(-O', 'MHRA-O', ')-O', 'with-O', 'suspected-O', 'kidney-O', 'adverse-O', 'effects-O', '.-O']
['Reports-O', 'that-O', 'satisfy-O', 'defined-O', 'criteria-O', 'were-O', 'classified-O', 'as-O', 'acute-B-Disease', 'kidney-O', 'injury-I-Disease', ',-O', 'kidney-O', 'tubular-O', 'dysfunction-O', 'and-O', 'Fanconi-B-Disease', 'syndrome-I-Disease', '.-O']
['Of-O', 'the-O', '407-O', 'Yellow-O', 'Card-O', 'records-O', 'analysed-O', ',-O', '106-O', 'satisfied-O', 'criteria-O', 'for-O', 'TDF-O', ',-O', 'related-O', 'kidney-B-Disease', 'disease-I-Disease', ',-O', 'of-O', 'which-O', '53-O', '(-O', '50-O', ')-O', 'had-O', 'features-O', 'of-O', 'kidney-B-Disease', 'tubular-I-Disease', 'dysfunction-I-Disease', ',-O', '35-O', '(-O', '33-O', ')-O', 'were-O', 'found-O', 'to-O', 'have-O', 'features-O', 'of-O', 'glomerular-I-Disease', 'dysfunction-I-Disease', 'and-O', '18-O', '(-O', '17-O', ')-O', 'had-O', 'Fanconi-B-Disease', 'syndrome-I-Disease', '.-O']
['The-O', 'median-O', 'TDF-B-Chemical', 'exposure-O', 'was-O', '316-O', 'days-O', '(-O', 'interquartile-O', 'range-O', '120-O', ',-O', '740-O', ')-O', '.-O', 'The-O', 'incidence-O', 'of-O', 'hospitalisation-O', 'for-O', 'TDF-B-Chemical', 'kidney-O', 'adverse-O', 'effects-O', 'was-O', 'high-O', ',-O', 'particularly-O', 'amongst-O', 'patients-O', 'with-O', 'features-O', 'of-O', 'Fanconi-B-Disease', 'syndrome-I-Disease', '.-O']
['The-O', 'pattern-O', 'of-O', 'kidney-B-Disease', 'syndromes-I-Disease', 'in-O', 'this-O', 'population-O', 'series-O', 'mirrors-O', 'that-O', 'reported-O', 'in-O', 'randomised-O', 'clinical-O', 'trials-O', '.-O']
['Cessation-O', 'of-O', 'TDF-B-Chemical']
['Incidence-O', 'of-O', 'postoperative-O', 'delirium-B-Disease', 'is-O', 'high-O', 'even-O', 'in-O', 'a-O', 'population-O', 'without-O', 'known-O', 'risk-O', 'factors-O', '.-O']
['PURPOSE-O', ':-O', 'Postoperative-O', 'delirium-B-Disease', 'is-O', 'a-O', 'recognized-O', 'complication-O', 'in-O', 'populations-O', 'at-O', 'risk-O', '.-O']
['The-O', 'aim-O', 'of-O', 'this-O', 'study-O', 'is-O', 'to-O', 'assess-O', 'the-O', 'prevalence-O', 'of-O', 'early-O', 'postoperative-O', 'delirium-B-Disease', 'in-O', 'a-O', 'population-O', 'without-O', 'known-O', 'risk-O', 'factors-O', 'admitted-O', 'to-O', 'the-O', 'ICU-O', 'for-O', 'postoperative-O', 'monitoring-O', 'after-O', 'elective-O', 'major-O', 'surgery-O', '.-O']
['The-O', 'secondary-O', 'outcome-O', 'investigated-O', 'is-O', 'to-O', 'identify-O', 'eventual-O', 'independent-O', 'risk-O', 'factors-O', 'among-O', 'demographic-O', 'data-O', 'and-O', 'anesthetic-O', 'drugs-O', 'used-O', '.-O']
['METHODS-O', ':-O', 'An-O', 'observational-O', ',-O', 'prospective-O', 'study-O', 'was-O', 'conducted-O', 'on-O', 'a-O', 'consecutive-O', 'cohort-O', 'of-O', 'patients-O', 'admitted-O', 'to-O', 'our-O', 'ICU-O', 'within-O', 'and-O', 'for-O', 'at-O', 'least-O', '24-O', 'h-O', 'after-O', 'major-O', 'surgical-O', 'procedures-O', '.-O']
['Exclusion-O', 'criteria-O', 'were-O', 'any-O', 'preexisting-O', 'predisposing-O', 'factor-O', 'for-O', 'delirium-B-Disease', 'or-O', 'other-O', 'potentially-O', 'confounding-O', 'neurological-O', 'dysfunctions-I-Disease', '.-O']
['Patients-O', 'were-O', 'assessed-O', 'daily-O', 'using-O', 'the-O', 'confusion-B-Disease', 'assessment-O', 'method-O', 'for-O', 'the-O', 'ICU-O', 'scale-O', 'for-O', '3-O', 'days-O', 'after-O', 'the-O', 'surgical-O', 'procedure-O', '.-O']
['Early-O', 'postoperative-O', 'delirium-B-Disease', 'incidence-O', 'risk-O', 'factors-O', 'were-O', 'then-O', 'assessed-O', 'through-O', 'three-O', 'different-O', 'multiple-O', 'regression-O', 'models-O', '.-O']
['RESULTS-O', ':-O', 'According-O', 'to-O', 'the-O', 'confusion-B-Disease', 'assessment-O', 'method-O', 'for-O', 'the-O', 'ICU-O', 'scale-O', ',-O', '28-O', '%-O', 'of-O', 'patients-O', 'were-O', 'diagnosed-O', 'with-O', 'early-O', 'postoperative-O', 'delirium-B-Disease', '.-O']
['The-O', 'use-O', 'of-O', 'thiopentone-B-Chemical', 'was-O', 'significantly-O', 'associated-O', 'with-O', 'an-O', 'eight-O', ',-O', 'fold-O', ',-O', 'higher-O', 'risk-O', 'for-O', 'delirium-B-Disease', 'compared-O', 'to-O', 'propofol-B-Chemical', '(-O', '57-O', '.-O']
['1-O', '%-O', 'vs-O', '.-O']
['7-O', '.-O']
['1-O', ',-O', 'RR-O', '=', '8-O', '.-O']
['0-O', ',-O', 'X2-O', '=', '4-O', '.-O']
['256-O', ';-O', 'df-O', '='-O', '1-O', ';-O', '0-O', '.-O']
['05-O', '<-O', 'p-O', '<-O', '0-O', '.-O']
['02-O', ').-O', 'CONCLUSION-O', ':-O', 'In-O', 'this-O', 'study-O', 'early-O', 'postoperative-B-Disease', 'delirium-B-Disease', 'was-O', 'found-O', 'to-O', 'be-O', 'a-O', 'very-O', 'common-O', 'complication-O', 'after-O', 'major-O', 'surgery-O', ',-O', 'even-O', 'in-O', 'a-O', 'population-O', 'without-O', 'known-O', 'risk-O', 'factors-O', '.-O']
['Thiopentone-B-Chemical']
['A-O', 'single-O', 'neurotoxic-B-Disease', 'dose-O', 'of-O', 'methamphetamine-B-Chemical', 'induces-O', 'a-O', 'long-O', ',-O', 'lasting-O', 'depressive-B-Disease', ',-O', 'like-O', 'behaviour-O', 'in-O', 'mice-O', '.-O']
['Methamphetamine-B-Chemical', '(-O', 'METH-B-Chemical', ')-O', 'triggers-O', 'a-O', 'disruption-O', 'of-O', 'the-O', 'monoaminergic-O', 'system-O', 'and-O', 'METH-B-Chemical', 'abuse-O', 'leads-O', 'to-O', 'negative-O', 'emotional-O', 'states-O', 'including-O', 'depressive-B-Disease', 'symptoms-O', 'during-O', 'drug-O', 'withdrawal-O', '.-O']
['However-O', ',-O', 'it-O', 'is-O', 'currently-O', 'unknown-O', 'if-O', 'the-O', 'acute-O', 'toxic-O', 'dosage-O', 'of-O', 'METH-B-Chemical', 'also-O', 'causes-O', 'a-O', 'long-O', ',-O', 'lasting-O', 'depressive-B-Disease', 'phenotype-O', 'and-O', 'persistent-O', 'monoaminergic-O', 'deficits-O', '.-O']
['Thus-O', ',-O', 'we-O', 'now-O', 'assessed-O', 'the-O', 'depressive-B-Disease', ',-O', 'like-O', 'behaviour-O', 'in-O', 'mice-O', 'at-O', 'early-O', 'and-O', 'long-O', ',-O', 'term-O', 'periods-O', 'following-O', 'a-O', 'single-O', 'high-O', 'METH-B-Chemical', 'dose-O', '(-O', '30-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', ').-O', 'METH-B-Chemical', 'did-O', 'not-O', 'alter-O', 'the-O', 'motor-O', 'function-O', 'and-O', 'procedural-O', 'memory-O', 'of-O', 'mice-O', 'as-O', 'assessed-O', 'by-O', 'swimming-O', 'speed-O', 'and-O', 'escape-O', 'latency-O', 'to-O', 'find-O', 'the-O', 'platform-O', 'in-O', 'a-O', 'cued-O', 'version-O', 'of-O', 'the-O', 'water-O', 'maze-O', 'task-O', '.-O']
['However-O', ',-O', 'METH-B-Chemical', 'significantly-O', 'increased-O', 'the-O', 'immobility-O', 'time-O', 'in-O', 'the-O', 'tail-O', 'suspension-O', 'test-O', 'at-O', '3-O', 'and-O', '49-O', 'days-O', 'post-O', ',-O', 'administration-O', '.-O']
['This-O', 'depressive-B-Disease', ',-O', 'like-O', 'profile-O', 'induced-O', 'by-O', 'METH-B-Chemical', 'was-O', 'accompanied-O', 'by-O', 'a-O', 'marked-O', 'depletion-O', 'of-O', 'frontostriatal-O', 'dopaminergic-O', 'and-O', 'serotonergic-O', 'neurotransmission-O', ',-O', 'indicated-O', 'by-O', 'a-O', 'reduction-O', 'in-O', 'the-O', 'levels-O', 'of-O', 'dopamine-B-Chemical', ',-O', 'DOPAC-B-Chemical', 'and-O', 'HVA-B-Chemical', ',-O', 'tyrosine-B-Chemical', 'hydroxylase-O', 'and-O', 'serotonin-B-Chemical', ',-O', 'observed-O', 'at-O', 'both-O', '3-O', 'and-O', '49-O', 'days-O', 'post-O', ',-O', 'administration-O', '.-O']
['In-O', 'parallel-O', ',-O', 'another-O', 'neurochemical-O', 'feature-O', 'of-O', 'depression-B-Disease', '--O', 'astroglial-O', 'dysfunction-O', '--O', 'was-O', 'unaffected-O', 'in-O', 'the-O', 'cortex-O', 'and-O', 'the-O', 'striatal-O', 'levels-O', 'of-O', 'the-O', 'astrocytic-O', 'protein-O', 'marker-O', ',-O', 'glial-O', 'fibrillary-O', 'acidic-O', 'protein-O', ',-O', 'were-O', 'only-O', 'transiently-O', 'increased-O', 'at-O', '3-O', 'days-O', '.-O']
['These-O', 'findings-O', 'demonstrate-O', 'for-O', 'the-O', 'first-O', 'time-O', 'that-O', 'a-O', 'single-O', 'high-O', 'dose-O', 'of-O', 'METH-B-Chemical', 'induces-O', 'long-O', ',-O', 'lasting-O', 'depressive-B-Disease']
['Linezolid-B-Chemical', ',-O', 'induced-O', 'optic-B-Disease', 'neuropathy-I-Disease', '.-O']
['Many-O', 'systemic-O', 'antimicrobials-O', 'have-O', 'been-O', 'implicated-O', 'to-O', 'cause-O', 'ocular-O', 'adverse-O', 'effects-O', '.-O']
['This-O', 'is-O', 'especially-O', 'relevant-O', 'in-O', 'multidrug-O', 'therapy-O', 'where-O', 'more-O', 'than-O', 'one-O', 'drug-O', 'can-O', 'cause-O', 'a-O', 'similar-O', 'ocular-O', 'adverse-O', 'effect-O', '.-O']
['We-O', 'describe-O', 'a-O', 'case-O', 'of-O', 'progressive-O', 'loss-B-Disease', 'of-O', 'vision-I-Disease', 'associated-O', 'with-O', 'linezolid-B-Chemical', 'therapy-O', '.-O']
['A-O', '45-O', ',-O', 'year-O', ',-O', 'old-O', 'male-O', 'patient-O', 'who-O', 'was-O', 'on-O', 'treatment-O', 'with-O', 'multiple-O', 'second-O', ',-O', 'line-O', 'anti-O', ',-O', 'tuberculous-O', 'drugs-O', 'including-O', 'linezolid-B-Chemical', 'and-O', 'ethambutol-B-Chemical', 'for-O', 'extensively-O', 'drug-resistant-O', 'tuberculosis-O', '(-O', 'XDR-TB-I-Disease', ')', 'presented-O', 'to-O', 'us-O', 'with-O', 'painless-O', 'progressive-O', 'loss-O', 'of-O', 'vision-I-Disease', 'in-O', 'both-O', 'eyes-O', '.-O']
['Color-O', 'vision-O', 'was-O', 'defective-O', 'and-O', 'fundus-O', 'examination-O', 'revealed-O', 'optic-B-Disease', 'disc-O', 'edema-I-Disease', 'in-O', 'both-O', 'eyes-O', '.-O']
['Ethambutol-B-Chemical', ',-O', 'induced-O', 'toxic-O', 'optic-B-Disease', 'neuropathy-I-Disease', 'was-O', 'suspected-O', 'and-O', 'tablet-O', 'ethambutol-B-Chemical', 'was-O', 'withdrawn-O', '.-O']
['Deterioration-B-Disease', 'of-O', 'vision-I-Disease', 'occurred-O', 'despite-O', 'withdrawal-O', 'of-O', 'ethambutol-B-Chemical', '.-O']
['Discontinuation-O', 'of-O', 'linezolid-B-Chemical', 'resulted-O', 'in-O', 'marked-O', 'improvement-O', 'of-O', 'vision-O', '.-O']
['Our-O', 'report-O', 'emphasizes-O', 'the-O', 'need-O', 'for-O', 'monitoring-O', 'of-O', 'visual-O', 'function-O', 'in-O', 'patients-O', 'on-O', 'long-O', ',-O', 'term-O', 'linezolid-B-Chemical']
['Resuscitation-O', 'with-O', 'lipid-O', ',-O', 'epinephrine-B-Chemical', ',-O', 'or-O', 'both-O', 'in-O', 'levobupivacaine-B-Chemical', ',-O', 'induced-O', 'cardiac-B-Disease', 'toxicity-I-Disease', 'in-O', 'newborn-O', 'piglets-O', '.-O']
['BACKGROUND-O', ':-O', 'The-O', 'optimal-O', 'dosing-O', 'regimens-O', 'of-O', 'lipid-B-Chemical', 'emulsion-O', ',-O', 'epinephrine-B-Chemical', ',-O', 'or-O', 'both-O', 'are-O', 'not-O', 'yet-O', 'determined-O', 'in-O', 'neonates-O', 'in-O', 'cases-O', 'of-O', 'local-O', 'anaesthetic-O', 'systemic-O', 'toxicity-O', '(-O', 'LAST-O', ')-O', '.-O', 'METHODS-O', ':-O', 'Newborn-O', 'piglets-O', 'received-O', 'levobupivacaine-B-Chemical', 'until-O', 'cardiovascular-O', 'collapse-O', 'occurred-O', '.-O']
['Standard-O', 'cardiopulmonary-O', 'resuscitation-O', 'was-O', 'started-O', 'and-O', 'electrocardiogram-O', '(-O', 'ECG-O', ')-O', 'was-O', 'monitored-O', 'for-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', ',-O', 'fibrillation-I-Disease', ',-O', 'or-O', 'QRS-O', 'prolongation-O', '.-O']
['Piglets-O', 'were-O', 'then-O', 'randomly-O', 'allocated-O', 'to-O', 'four-O', 'groups-O', ':-O', 'control-O', '(-O', 'saline-O', '), ,-O', 'Intralipid-B-Chemical', ',-O', 'alone-O', ',-O', 'epinephrine-B-Chemical', 'alone-O', ',-O', 'or-O', 'a-O', 'combination-O', 'of-O', 'Intralipd-B-Chemical', 'plus-O', 'epinephrine-B-Chemical', '.-O']
['Resuscitation-O', 'continued-O', 'for-O', '30-O', 'min-O', 'or-O', 'until-O', 'there-O', 'was-O', 'a-O', 'return-O', 'of-O', 'spontaneous-O', 'circulation-O', '(-O', 'ROSC-O', ')-O', 'accompanied-O', 'by-O', 'a-O', 'mean-O', 'arterial-O', 'pressure-O', 'at-O', 'or-O', 'superior-O', 'to-O', 'the-O', 'baseline-O', 'pressure-O', 'and-O', 'normal-O', 'sinus-O', 'rhythm-O', 'for-O', 'a-O', 'period-O', 'of-O', '30-O', 'min-O', '.-O']
['RESULTS-O', ':-O', 'ROSC-O', 'was-O', 'achieved-O', 'in-O', 'only-O', 'one-O', 'of-O', 'the-O', 'control-O', 'piglets-O', 'compared-O', 'with-O', 'most-O', 'of-O', 'the-O', 'treated-O', 'piglets-O', '.-O']
['Mortality-O', 'was-O', 'not-O', 'significantly-O', 'different-O', 'between-O', 'the-O', 'three-O', 'treatment-O', 'groups-O', ',-O', 'but-O', 'was-O', 'significantly-O', 'lower-O', 'in-O', 'all-O', 'the-O', 'treatment-O', 'groups-O', 'compared-O', 'with-O', 'control-O', '.-O']
['The-O', 'number-O', 'of-O', 'ECG-O', 'abnormalities-O', 'was-O', 'zero-O', 'in-O', 'the-O', 'Intralipid-B-Chemical', 'only-O', 'group-O', ',-O', 'but-O', '14-O', 'and-O', '17-O', ',-O', 'respectively-O', ',-O', 'in-O', 'the-O', 'epinephrine-B-Chemical', 'and-O', 'epinephrine-B-Chemical', 'plus-O', 'lipid-O', 'groups-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['05-O', ')-O', 'CONCLUSIONS-O', ':-O', 'Lipid-O', 'emulsion-O', 'with-O', 'or-O', 'without-O', 'epinephrine-B-Chemical', ',-O', 'or-O', 'epinephrine-B-Chemical', 'alone-O', 'were-O', 'equally-O', 'effective-O', 'in-O', 'achieving-O', 'a-O', 'return-O', 'to-O', 'spontaneous-O', 'circulation-O', 'in-O', 'this-O', 'model-O', 'of-O', 'LAST-B-Disease', '.-O']
['Epinephrine-B-Chemical']
['Incidence-O', 'of-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', 'type-O', 'II-O', 'and-O', 'postoperative-O', 'recovery-O', 'of-O', 'platelet-O', 'count-O', 'in-O', 'liver-O', 'graft-O', 'recipients-O', ':-O', 'a-O', 'retrospective-O', 'cohort-O', 'analysis-O', '.-O']
['BACKGROUND-O', ':-O', 'Thrombocytopenia-B-Disease', 'in-O', 'patients-O', 'with-O', 'end-stage-B-Disease', 'liver-O', 'disease-I-Disease', 'is-O', 'a-O', 'common-O', 'disorder-O', 'caused-O', 'mainly-O', 'by-O', 'portal-O', 'hypertension-B-Disease', ',-O', 'low-O', 'levels-O', 'of-O', 'thrombopoetin-B-Chemical', ',-O', 'and-O', 'endotoxemia-B-Disease', '.-O']
['The-O', 'impact-O', 'of-O', 'immune-O', ',-O', 'mediated-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', 'type-O', 'II-I-Disease', '(-O', 'HIT-B-Disease', 'type-O', 'II-I-Disease', ')-O', 'as-O', 'a-O', 'cause-O', 'of-O', 'thrombocytopenia-B-Disease', 'after-O', 'liver-O', 'transplantation-O', 'is-O', 'not-O', 'yet-O', 'understood-O', ',-O', 'with-O', 'few-O', 'literature-O', 'citations-O', 'reporting-O', 'contradictory-O', 'results-O', '.-O']
['The-O', 'aim-O', 'of-O', 'our-O', 'study-O', 'was-O', 'to-O', 'demonstrate-O', 'the-O', 'perioperative-O', 'course-O', 'of-O', 'thrombocytopenia-B-Disease', 'after-O', 'liver-O', 'transplantation-O', 'and-O', 'determine-O', 'the-O', 'occurrence-O', 'of-O', 'clinical-O', 'HIT-B-Disease', 'type-O', 'II-O', '.-O']
['METHOD-O', ':-O', 'We-O', 'retrospectively-O', 'evaluated-O', 'the-O', 'medical-O', 'records-O', 'of-O', '205-O', 'consecutive-O', 'adult-O', 'patients-O', 'who-O', 'underwent-O', 'full-O', ',-O', 'size-O', 'liver-O', 'transplantation-O', 'between-O', 'January-O', '2006-O', 'and-O', 'December-O', '2010-O', 'due-O', 'to-O', 'end-stage-O', 'or-O', 'malignant-O', 'liver-B-Disease', '.-O']
['Preoperative-O', 'platelet-O', 'count-O', ',-O', 'postoperative-O', 'course-O', 'of-O', 'platelets-O', ',-O', 'and-O', 'clinical-O', 'signs-O', 'of-O', 'HIT-B-Disease', 'type-O', 'II-I-Disease', 'were-O', 'analyzed-O', '.-O']
['RESULTS-O', ':-O', 'A-O', 'total-O', 'of-O', '155-O', '(-O', '75-O', '.-O']
['6-O', ')-O', 'of-O', '205-O', 'patients-O', 'had-O', 'thrombocytopenia-B-Disease', 'before-O', 'transplantation-O', ',-O', 'significantly-O', 'influenced-O', 'by-O', 'Model-O', 'of-O', 'End-Stage-O', 'Liver-O', 'Disease-B-Disease', 'score-O', 'and-O', 'liver-O', 'cirrhosis-B-Disease', '.-O']
['The-O', 'platelet-O', 'count-O', 'exceeded-O', '100-O', ',-O', '000-O', '/-O', 'uL-O', 'in-O', 'most-O', 'of-O', 'the-O', 'patients-O', '(-O', 'n-O', '=O', '193-O', ')-O', 'at-O', 'a-O', 'medium-O', 'of-O', '7-O', 'd-O', '.-O']
['Regarding-O', 'HIT-B-Disease', 'II-B-Disease', ',-O', 'there-O', 'were-O', 'four-O', '(-O', '1-O', '.-O']
['95-O', ')-O', 'patients-O', 'with-O', 'a-O', 'background-O', 'of-O', 'HIT-B-Disease', 'type-O', 'II-I-Disease', '.-O']
['CONCLUSIONS-O', ':-O', 'The-O', 'incidence-O', 'of-O', 'HIT-B-Disease', 'in-O', 'patients-O', 'with-O', 'end-stage-B-Disease', 'hepatic-I-Disease', 'failure-I-Disease', 'is-O', ',-O', 'with-O', 'about-O', '1-O', '.-O']
['95-O', ',-O', 'rare-O', '.-O']
['For-O', 'further-O', 'reduction-O', 'of-O', 'HIT-B-Disease', 'type-O', 'II-O', ',-O', 'the-O', 'use-O', 'of-O', 'intravenous-O', 'heparin-B-Chemical', 'should-O', 'be-O', 'avoided-O', 'and-O', 'the-O', 'prophylactic-O', 'anticoagulation-O', 'should-O', 'be-O', 'performed-O', 'with-O', 'low-O', ',-O', 'molecular-O', ',-O', 'weight-O', 'heparin-B-Chemical']
['Takotsubo-B-Disease', 'syndrome-I-Disease', '(-O', 'or-O', 'apical-O', 'ballooning-O', 'syndrome-O', ')-O', 'secondary-O', 'to-O', 'Zolmitriptan-B-Chemical', '.-O']
['Takotsubo-O', 'syndrome-O', '(-O', 'TS-O', '),,-O', 'also-O', 'known-O', 'as-O', 'broken-O', 'heart-O', 'syndrome-O', ',-O', 'is-O', 'characterized-O', 'by-O', 'left-O', 'ventricle-O', 'apical-O', 'ballooning-O', 'with-O', 'elevated-O', 'cardiac-O', 'biomarkers-O', 'and-O', 'electrocardiographic-O', 'changes-O', 'suggestive-O', 'of-O', 'an-O', 'acute-O', 'coronary-O', 'syndrome-O', '(-O', 'ie-O', ',-O', 'ST-O', ',-O', 'segment-O', 'elevation-O', ',-O', 'T-O', 'wave-O', 'inversions-O', ',-O', 'and-O', 'pathologic-O', 'Q-O', 'waves-O', ').,-O', 'We-O', 'report-O', 'a-O', 'case-O', 'of-O', '54-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'with-O', 'medical-O', 'history-O', 'of-O', 'mitral-B-Disease', 'valve-I-Disease', 'prolapse-I-Disease', 'and-O', 'migraines-O', ',-O', 'who-O', 'was-O', 'admitted-O', 'to-O', 'the-O', 'hospital-O', 'for-O', 'substernal-O', 'chest-O', 'pain-O', 'and-O', 'electrocardiogram-O', 'demonstrated-O', '1-O', '/-O', '2-O', 'mm-O', 'ST-O', ',-O', 'segment-O', 'elevation-O', 'in-O', 'leads-O', 'II-O', ',-O', 'III-O', ',-O', 'aVF-O', ',-O', 'V5-O', ',-O', 'and-O', 'V6-O', 'and-O', 'positive-O', 'troponin-I-B-Chemical', '.-O']
['Emergent-O', 'coronary-O', 'angiogram-O', 'revealed-O', 'normal-O', 'coronary-O', 'arteries-O', 'with-O', 'moderately-O', 'reduced-O', 'left-O', 'ventricular-O', 'ejection-O', 'fraction-O', 'with-O', 'wall-O', 'motion-O', 'abnormalities-O', 'consistent-O', 'with-O', 'TS-B-Disease', '.-O']
['Detailed-O', 'history-O', 'obtained-O', 'retrospectively-O', 'revealed-O', 'that-O', 'the-O', 'patient-O', 'took-O', 'zolmitriptan-B-Chemical', 'sparingly-O', 'only-O', 'when-O', 'she-O', 'had-O', 'migraines-B-Disease', '.-O']
['But-O', 'before-O', 'this-O', 'event-O', ',-O', 'she-O', 'was-O', 'taking-O', 'zolmitriptan-B-Chemical', '2-O', ',-O', '3-O', 'times-O', 'daily-O', 'for-O', 'several-O', 'days-O', 'because-O', 'of-O', 'a-O', 'persistent-O', 'migraine-B-Disease', 'headache-B-Disease', '.-O']
['She-O', 'otherwise-O', 'reported-O', 'that-O', 'she-O', 'is-O', 'quite-O', 'active-O', ',-O', 'rides-O', 'horses-O', ',-O', 'and-O', 'does-O', 'show-O', 'jumping-O', 'without-O', 'any-O', 'limitations-O', 'in-O', 'her-O', 'physical-O', 'activity-O', '.-O']
['There-O', 'was-O', 'no-O', 'evidence-O', 'of-O', 'any-O', 'recent-O', 'stress-O', 'or-O', 'status-O', 'migrainosus-B-Disease', '.-O']
['Extensive-O', 'literature-O', 'search-O', 'revealed-O', 'multiple-O', 'cases-O', 'of-O', 'coronary-O', 'artery-O', 'vasospasm-B-Disease', 'secondary-O', 'to-O', 'zolmitriptan-B-Chemical', ',-O', 'but-O', 'none-O', 'of-O', 'the-O', 'cases-O', 'were-O', 'associated-O', 'with-O', 'TS-O']
['Depression-B-Disease', ',-O', 'impulsiveness-B-Disease', ',-O', 'sleep-O', ',-O', 'and-O', 'memory-O', 'in-O', 'past-O', 'and-O', 'present-O', 'polydrug-O', 'users-O', 'of-O', '3,4-methylenedioxymethamphetamine-B-Chemical', '(-O', 'MDMA-B-Chemical', ',-O', 'ecstasy-B-Chemical', ').-O', 'RATIONALE-O', ':-O', 'Ecstasy-B-Chemical', '(-O', '3,4-methylenedioxymethamphetamine-B-Chemical', ',-O', 'MDMA-B-Chemical', ')', 'is-O', 'a-O', 'worldwide-O', 'recreational-O', 'drug-O', 'of-O', 'abuse-O', '.-O']
['Unfortunately-O', ',-O', 'the-O', 'results-O', 'from-O', 'human-O', 'research-O', 'investigating-O', 'its-O', 'psychological-O', 'effects-O', 'have-O', 'been-O', 'inconsistent-O', '.-O']
['OBJECTIVES-O', ':-O', 'The-O', 'present-O', 'study-O', 'aimed-O', 'to-O', 'be-O', 'the-O', 'largest-O', 'to-O', 'date-O', 'in-O', 'sample-O', 'size-O', 'and-O', '5HT-O', ',-O', 'related-O', 'behaviors-O', ';-O', 'the-O', 'first-O', 'to-O', 'compare-O', 'present-O', 'ecstasy-B-Chemical', 'users-O', 'with-O', 'past-O', 'users-O', 'after-O', 'an-O', 'abstinence-O', 'of-O', '4-O', 'or-O', 'more-O', 'years-O', ',-O', 'and-O', 'the-O', 'first-O', 'to-O', 'include-O', 'robust-O', 'controls-O', 'for-O', 'other-O', 'recreational-O', 'substances-O', '.-O']
['METHODS-O', ':', 'A-O', 'sample-O', 'of-O', '997-O', 'participants-O', '(-O', '52-O', '%-O', 'male-O', ')-O', 'was-O', 'recruited-O', 'to-O', 'four-O', 'control-O', 'groups-O', '(-O', 'non-O', ',-O', 'drug-O', '(-O', 'ND-O', ')-O', 'alcohol-O', '/-O', 'nicotine-B-Chemical', '(-O', 'AN-O', ')-O', 'cannabis-B-Chemical', '/-O', 'alcohol-O', '/-O', 'nicotine-B-Chemical', '(-O', 'CAN-O', ')-O', 'non-O', ',-O', 'ecstasy-B-Chemical', 'polydrug-O', '(-O', 'PD-O', '))-O', 'and-O', 'two-O', 'ecstasy-B-Chemical', 'polydrug-O', 'groups-O', '(-O', 'present-O', '(-O', 'MDMA-B-Chemical', ')-O', 'and-O', 'past-O', 'users-O', '(-O', 'EX-O', ',-O', 'MDMA-B-Chemical', '))-O', '.-O', 'Participants-O', 'completed-O', 'a-O', 'drug-O', 'history-O', 'questionnaire-O', ',-O', 'Beck-O', 'Depression-O', 'Inventory-O', ',-O', 'Barratt-O', 'Impulsiveness-O', 'Scale-O', ',-O', 'Pittsburgh-O', 'Sleep-O', 'Quality-O', 'Index-O', ',-O', 'and-O', 'Wechsler-O', 'Memory-O', 'Scale-O', ',-O', 'Revised-O', 'which-O', ',-O', 'in-O', 'total-O', ',-O', 'provided-O', '13-O', 'psychometric-O', 'measures-O', '.-O']
['RESULTS-O', ':-O', 'While-O', 'the-O', 'CAN-O', 'and-O', 'PD-O', 'groups-O', 'tended-O', 'to-O', 'record-O', 'greater-O', 'deficits-O', 'than-O', 'the-O', 'non-O', ',-O', 'drug-O', 'controls-O', ',-O', 'the-O', 'MDMA-B-Chemical', 'and-O', 'EX-O', ',-O', 'MDMA-B-Chemical', 'groups-O', 'recorded-O', 'greater-O', 'deficits-O', 'than-O', 'all-O', 'the-O', 'control-O', 'groups-O', 'on-O', 'ten-O', 'of-O', 'the-O', '13-O', 'psychometric-O', 'measures-O', '.-O']
['Strikingly-O', ',-O', 'despite-O', 'prolonged-O', 'abstinence-O', '(-O', 'mean-O', ',-O', '4-O', '.-O']
['98-O', ';-O', 'range-O', ',-O', '4-O', ',-O', '9-O', 'years-O', ')-O', 'past-O', 'ecstasy-B-Chemical', 'users-O', 'showed-O', 'few-O', 'signs-O', 'of-O', 'recovery-O', '.-O']
['Compared-O', 'with-O', 'present-O', 'ecstasy-B-Chemical', 'users-O', ',-O', 'the-O', 'past-O', 'users-O', 'showed-O', 'no-O', 'change-O', 'for-O', 'ten-O', 'measures-O', ',-O', 'increased-O', 'impairment-O', 'for-O', 'two-O', 'measures-O', ',-O', 'and-O', 'improvement-O', 'on-O', 'just-O', 'one-O', 'measure-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Given-O', 'this-O', 'record-O', 'of-O', 'impaired-O', 'memory-B-Disease', 'and-O', 'clinically-O', 'significant-O', 'levels-O', 'of-O', 'depression-B-Disease', ',-O', 'impulsiveness-B-Disease', ',-O', 'and-O', 'sleep-O', 'disturbance-B-Disease', ',-O', 'the-O', 'prognosis-O', 'for-O', 'the-O', 'current-O', 'generation-O', 'of-O', 'ecstasy-B-Chemical']
['Association-O', 'of-O', 'common-O', 'genetic-O', 'variants-O', 'of-O', 'HOMER1-O', 'gene-O', 'with-O', 'levodopa-B-Chemical', 'adverse-O', 'effects-O', 'in-O', 'Parkinson-B-Disease', 'disease-I-Disease', 'patients-O', '.-O']
['Levodopa-B-Chemical', 'is-O', 'the-O', 'most-O', 'effective-O', 'symptomatic-O', 'therapy-O', 'for-O', 'Parkinson-B-Disease', 'disease-I-Disease', ',-O', 'but-O', 'its-O', 'chronic-O', 'use-O', 'could-O', 'lead-O', 'to-O', 'chronic-O', 'adverse-O', 'outcomes-O', ',-O', 'such-O', 'as-O', 'motor-O', 'fluctuations-O', ',-O', 'dyskinesia-B-Disease', 'and-O', 'visual-B-Disease', 'hallucinations-I-Disease', '.-O']
['HOMER1-O', 'is-O', 'a-O', 'protein-O', 'with-O', 'pivotal-O', 'function-O', 'in-O', 'glutamate-B-Chemical', 'transmission-O', ',-O', 'which-O', 'has-O', 'been-O', 'related-O', 'to-O', 'the-O', 'pathogenesis-O', 'of-O', 'these-O', 'complications-O', '.-O']
['This-O', 'study-O', 'investigates-O', 'whether-O', 'polymorphisms-O', 'in-O', 'the-O', 'HOMER1-O', 'gene-O', 'promoter-O', 'region-O', 'are-O', 'associated-O', 'with-O', 'the-O', 'occurrence-O', 'of-O', 'the-O', 'chronic-B-Disease', 'complications-O', 'of-O', 'levodopa-B-Chemical', 'therapy-O', '.-O']
['A-O', 'total-O', 'of-O', '205-O', 'patients-O', 'with-O', 'idiopathic-B-Disease', 'Parkinson-B-Disease', 'disease-I-Disease', 'were-O', 'investigated-O', '.-O']
['Patients-O', 'were-O', 'genotyped-O', 'for-O', 'rs4704559-O', ',-O', 'rs10942891-O', 'and-O', 'rs4704560-O', 'by-O', 'allelic-O', 'discrimination-O', 'with-O', 'Taqman-O', 'assays-O', '.-O']
['The-O', 'rs4704559-O', 'G-O', 'allele-O', 'was-O', 'associated-O', 'with-O', 'a-O', 'lower-O', 'prevalence-O', 'of-O', 'dyskinesia-B-Disease', '(-O', 'prevalence-O', 'ratio-O', '(-O', 'PR-O', ')-O', '0-O', '.-O']
['615-O', ',-O', '95-O', '%-O', 'confidence-O', 'interval-O', '(-O', 'CI-O', ')-O', '0-O', '.-O']
['426-O', ',-O', '0-O', '.-O']
['887-O', ',-O', 'P-O', '=O', '0-O', '.-O']
['009-O', ')-O', 'and-O', 'visual-B-Disease', 'hallucinations-I-Disease', '(-O', 'PR-O', '=', '0-O', '.-O']
['515-O', ',-O', '95-O', '%-O', 'CI-O', '0-O', '.-O']
['295-O', ',-O', '0-O', '.-O']
['899-O', ',-O', 'P-O', '=O', '0-O', '.-O']
['020-O', ').-O', 'Our-O', 'data-O', 'suggest-O', 'that-O', 'HOMER1-O', 'rs4704559-O', 'G-O', 'allele-O', 'has-O', 'a-O', 'protective-O', 'role-O', 'for-O', 'the-O', 'development-O', 'of-O', 'levodopa-B-Chemical']
['Crocin-B-Chemical', 'improves-O', 'lipid-O', 'dysregulation-B-Disease', 'in-O', 'subacute-O', 'diazinon-B-Chemical', 'exposure-O', 'through-O', 'ERK1-B-Chemical', '/', '2-B-Chemical', 'pathway-O', 'in-O', 'rat-O', 'liver-O', '.-O']
['INTRODUCTION-O', ':-O', 'Diazinon-B-Chemical', 'Yis-O', 'one-O', 'of-O', 'the-O', 'most-O', 'broadly-O', 'used-O', 'organophosphorus-O', 'insecticides-O', 'in-O', 'agriculture-O', '.-O']
['It-O', 'has-O', 'been-O', 'shown-O', 'that-O', 'exposure-O', 'to-O', 'diazinon-B-Chemical', 'may-O', 'interfere-O', 'with-O', 'lipid-O', 'metabolism-O', '.-O']
['Moreover-O', ',-O', 'the-O', 'hypolipidemic-O', 'effect-O', 'of-O', 'crocin-B-Chemical', 'has-O', 'been-O', 'established-O', '.-O']
['Earlier-O', 'studies-O', 'revealed-O', 'the-O', 'major-O', 'role-O', 'of-O', 'Extracellular-O', 'signal-O', 'regulated-O', 'kinase-O', '(-O', 'ERK-O', ')', 'pathways-O', 'in-O', 'low-O', 'density-O', 'lipoprotein-O', 'receptor-O', '(-O', 'LDLr-O', ')', 'expression-O', '.-O']
['The-O', 'aim-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'evaluate-O', 'changes-O', 'in-O', 'the-O', 'regulation-O', 'of-O', 'lipid-O', 'metabolism-O', ',-O', 'ERK-O', 'and-O', 'LDLr-O', 'expression-O', 'in-O', 'the-O', 'liver-O', 'of-O', 'rats-O', 'exposed-O', 'to-O', 'subacute-O', 'diazinon-B-Chemical', '.-O']
['Furthermore-O', 'ameliorating-O', 'effect-O', 'of-O', 'crocin-B-Chemical', 'on-O', 'diazinon-B-Chemical', 'induced-O', 'disturbed-O', 'cholesterol-B-Chemical', 'homeostasis-O', 'was-O', 'studied-O', '.-O']
['METHODS-O', ':-O', '24-O', 'Rats-O', 'were-O', 'divided-O', 'into-O', '4-O', 'groups-O', 'and-O', 'received-O', 'following-O', 'treatments-O', 'for-O', '4-O', 'weeks-O', ';-O', 'Corn-O', 'oil-O', '(-O', 'control-O', ')-O', ',', 'diazinon-B-Chemical', '(-O', '15mg-O', '/-O', 'kg-O', 'per-O', 'day-O', ',-O', 'orally-O', ')-O', 'and-O', 'crocin-B-Chemical', '(-O', '12-O', '.-O']
['5-O', 'and-O', '25mg-O', '/-O', 'kg-O', 'per-O', 'day-O', ',-O', 'intraperitoneally-O', ')-O', 'in-O', 'combination-O', 'with-O', 'diazinon-B-Chemical', '(-O', '15-O', 'mg-O', '/-O', 'kg-O', ')-O', '.-O', 'The-O', 'levels-O', 'of-O', 'cholesterol-B-Chemical', ',-O', 'triglyceride-B-Chemical', 'and-O', 'LDL-B-Chemical', 'in-O', 'blood-O', 'of-O', 'rats-O', 'were-O', 'analyzed-O', '.-O']
['Moreover-O', 'mRNA-O', 'levels-O', 'of-O', 'LDLr-O', 'and-O', 'ERK1-O', '/', '2-O', 'as-O', 'well-O', 'as-O', 'protein-O', 'levels-O', 'of-O', 'total-O', 'and-O', 'activated-O', 'forms-O', 'of-O', 'ERK1-O', '/', '2-O', 'in-O', 'rat-O', 'liver-O', 'were-O', 'evaluated-O', 'by-O', 'Western-O', 'blotting-O', 'and-O', 'quantitative-O', 'real-O', 'time-O', 'polymerase-O', 'chain-O', 'reaction-O', 'analysis-O', '.-O']
['RESULTS-O', ':-O', 'Our-O', 'data-O', 'showed-O', 'that-O', 'subacute-O', 'exposure-O', 'to-O', 'diazinon-B-Chemical', 'significantly-O', 'increased-O', 'concentrations-O', 'of-O', 'cholesterol-B-Chemical', ',-O', 'triglyceride-O', 'and-O', 'LDL-O', '.-O']
['Moreover-O', 'diazinon-B-Chemical', 'decreased-O', 'ERK1-O', '/', '2-O', 'protein-O', 'phosphorylation-O', 'and-O', 'LDLr-O', 'transcript-O', '.-O']
['Crocin-B-Chemical', 'reduced-O', 'inhibition-O', 'of-O', 'ERK-O', 'activation-O', 'and-O', 'diazinon-B-Chemical', ',-O', 'induced-O', 'hyperlipemia-B-Disease', 'and-O', 'increased-O', 'levels-O', 'of-O', 'LDLr-O', 'transcript-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Crocin-B-Chemical', 'may-O', 'be-O', 'considered-O', 'as-O', 'a-O', 'novel-O', 'protective-O', 'agent-O', 'in-O', 'diazinon-B-Chemical', ',-O', 'induced-O', 'hyperlipemia-B-Disease']
['GEM-B-Chemical', ',-O', 'P-O', 'chemotherapy-O', 'is-O', 'active-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'relapsed-O', 'Hodgkin-B-Disease', 'lymphoma-I-Disease', '.-O']
['Hodgkin-B-Disease', 'lymphoma-I-Disease', '(-O', 'HL-O', ')-O', 'is-O', 'a-O', 'relatively-O', 'chemosensitive-O', 'malignancy-O', '.-O']
['However-O', ',-O', 'for-O', 'those-O', 'who-O', 'relapse-O', ',-O', 'high-O', ',-O', 'dose-O', 'chemotherapy-O', 'with-O', 'autologous-O', 'stem-O', 'cell-O', 'transplant-O', 'is-O', 'the-O', 'treatment-O', 'of-O', 'choice-O', 'which-O', 'relies-O', 'on-O', 'adequate-O', 'disease-O', 'control-O', 'with-O', 'salvage-O', 'chemotherapy-O', '.-O']
['Regimens-O', 'commonly-O', 'used-O', 'often-O', 'require-O', 'inpatient-O', 'administration-O', 'and-O', 'can-O', 'be-O', 'difficult-O', 'to-O', 'deliver-O', 'due-O', 'to-O', 'toxicity-B-Disease', '.-O']
['Gemcitabine-B-Chemical', 'and-O', 'cisplatin-B-Chemical', 'have-O', 'activity-O', 'in-O', 'HL-O', ',-O', 'non-O', '-O', 'overlapping-O', 'toxicity-O', 'with-O', 'first-O', ',-O', 'line-O', 'chemotherapeutics-O', ',-O', 'and-O', 'may-O', 'be-O', 'delivered-O', 'in-O', 'an-O', 'outpatient-O', 'setting-O', '.-O']
['In-O', 'this-O', 'retrospective-O', 'single-O', ',-O', 'centre-O', 'analysis-O', ',-O', 'patients-O', 'with-O', 'relapsed-O', 'or-O', 'refractory-O', 'HL-B-Disease', 'treated-O', 'with-O', 'gemcitabine-B-Chemical', '1-O', ',-O', '000-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'day-O', '(-O', 'D-O', ')-O', '1-O', ',-O', 'D8-O', 'and-O', 'D15-O', ';-O', 'methylprednisolone-B-Chemical', '1-O', ',-O', '000-O', 'mg-O', 'D1-O', ',-O', '5-O', ';-O', 'and-O', 'cisplatin-B-Chemical', '100-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'D15-O', ',-O', 'every-O', '28-O', 'days-O', '(-O', 'GEM-B-Chemical', ',-O', 'P-O', ')-O', 'were-O', 'included-O', '.-O']
['Demographic-O', ',-O', 'survival-O', ',-O', 'response-O', 'and-O', 'toxicity-B-Disease', 'data-O', 'were-O', 'recorded-O', '.-O']
['Forty-O', ',-O', 'one-O', 'eligible-O', 'patients-O', 'were-O', 'identified-O', ':-O', 'median-O', 'age-O', '27-O', '.-O']
['One-O', 'hundred-O', 'and-O', 'twenty-O', ',-O', 'two-O', 'cycles-O', 'of-O', 'GEM-B-Chemical', ',-O', 'P-O', 'were-O', 'administered-O', 'in-O', 'total-O', '(-O', 'median-O', '3-O', 'cycles-O', ';-O', 'range-O', '1-O', ',-O', '6-O', ').-O', 'Twenty-O', 'of-O', '41-O', '(-O', '48-O', ')-O', 'patients-O', 'received-O', 'GEM-B-Chemical', ',-O', 'P-O', 'as-O', 'second-O', ',-O', 'line-O', 'treatment-O', 'and-O', '11-O', '/-O', '41-O', '(-O', '27-O', ')-O', 'as-O', 'third-O', ',-O', 'line-O', 'therapy-O', '.-O']
['Overall-O', 'response-O', 'rate-O', '(-O', 'ORR-O', ')-O', 'to-O', 'GEM-B-Chemical', ',-O', 'P-O', 'in-O', 'the-O', 'entire-O', 'cohort-O', 'was-O', '80-O', '(-O', 'complete-O', 'response-O', '(-O', 'CR-O', ')-O', '37-O', ',-O', 'partial-O', 'response-O', '44-O', ')-O', 'with-O', '14-O', '/-O', '15-O', 'CR-O', 'confirmed-O', 'as-O', 'a-O', 'metabolic-O', 'CR-O', 'on-O', 'PET-O', 'and-O', 'ORR-O', 'of-O', '85-O', '%-O', 'in-O', 'the-O', '20-O', 'second-O', ',-O', 'line-O', 'patients-O', '.-O']
['The-O', 'most-O', 'common-O', 'grade-O', '3-O', '/-O', '4-O', 'toxicities-O', 'were-O', 'haematological-O', ':-O', 'neutropenia-B-Disease', '54-O', '%-O', 'and-O', 'thrombocytopenia-B-Disease', '51-O', '.-O', 'Median-O', 'follow-O', ',-O', 'up-O', 'from-O', 'the-O', 'start-O', 'of-O', 'GEM-B-Chemical', ',-O', 'P-O', 'was-O', '4-O', '.-O']
['5-O', 'years-O', '.-O']
['Following-O', 'GEM-B-Chemical', ',-O', 'P-O', ',-O', '5-O', ',-O', 'year-O', 'progression-O', ',-O', 'free-O', 'survival-O', 'was-O', '46-O', '(-O', '95-O', '%-O', 'confidence-O', 'interval-O', '(-O', 'CI-O', '),', '30-O', ',-O', '62-O', ')-O', 'and-O', '5-O', ',-O', 'year-O', 'overall-O', 'survival-O', 'was-O', '59-O', '(-O', '95-O', '%-O', 'CI-O', ',-O', '43-O', ',-O', '74-O', ')-O', '.', 'Fourteen-O', 'of-O', '41-O', 'patients-O', 'proceeded-O', 'directly-O', 'to-O', 'autologous-O', 'transplant-O', '.-O']
['GEM-B-Chemical', ',-O', 'P-O', 'is-O', 'a-O', 'salvage-O', 'chemotherapy-O', 'with-O', 'relatively-O', 'high-O', 'response-O', 'rates-O', ',-O', 'leading-O', 'to-O', 'successful-O', 'transplantation-O', 'in-O', 'appropriate-O', 'patients-O', ',-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'relapsed-O', 'or-O', 'refractory-O', 'HL-B-Disease']
['Basal-O', 'functioning-O', 'of-O', 'the-O', 'hypothalamic-O', ',-O', 'pituitary-O', ',-O', 'adrenal-O', '(-O', 'HPA-O', ')-O', 'axis-O', 'and-O', 'psychological-O', 'distress-O', 'in-O', 'recreational-O', 'ecstasy-B-Chemical', 'polydrug-O', 'users-O', '.-O']
['RATIONALE-O', ':-O', 'Ecstasy-B-Chemical', '(-O', 'MDMA-B-Chemical', ')-O', 'is-O', 'a-O', 'psychostimulant-O', 'drug-O', 'which-O', 'is-O', 'increasingly-O', 'associated-O', 'with-O', 'psychobiological-O', 'dysfunction-O', '.-O']
['While-O', 'some-O', 'recent-O', 'studies-O', 'suggest-O', 'acute-O', 'changes-O', 'in-O', 'neuroendocrine-O', 'function-O', ',-O', 'less-O', 'is-O', 'known-O', 'about-O', 'long-O', ',-O', 'term-O', 'changes-O', 'in-O', 'HPA-O', 'functionality-O', 'in-O', 'recreational-O', 'users-O', '.-O']
['OBJECTIVES-O', ':-O', 'The-O', 'current-O', 'study-O', 'is-O', 'the-O', 'first-O', 'to-O', 'explore-O', 'the-O', 'effects-O', 'of-O', 'ecstasy-B-Chemical', ',-O', 'polydrug-O', 'use-O', 'on-O', 'psychological-O', 'distress-O', 'and-O', 'basal-O', 'functioning-O', 'of-O', 'the-O', 'HPA-O', 'axis-O', 'through-O', 'assessing-O', 'the-O', 'secretion-O', 'of-O', 'cortisol-B-Chemical', 'across-O', 'the-O', 'diurnal-O', 'period-O', '.-O']
['METHOD-O', ':-O', 'Seventy-O', ',-O', 'six-O', 'participants-O', '(-O', '21-O', 'nonusers-O', ',-O', '29-O', 'light-O', 'ecstasy-Chemical', ',-O', 'polydrug-O', 'users-O', ',-O', '26-O', 'heavy-O', 'ecstasy-Chemical', ',-O', 'polydrug-O', 'users-O', ')-O', 'completed-O', 'a-O', 'substance-O', 'use-O', 'inventory-O', 'and-O', 'measures-O', 'of-O', 'psychological-O', 'distress-O', 'at-O', 'baseline-O', ',-O', 'then-O', 'two-O', 'consecutive-O', 'days-O', 'of-O', 'cortisol-O', 'sampling-O', '(-O', 'on-O', 'awakening-O', ',-O', '30-O', 'min-O', 'post-O', 'awakening-O', ',-O', 'between-O', '1400-O', 'and-O', '1600-O', 'hours-O', 'and-O', 'pre-O', 'bedtime-O', ').-O', 'On-O', 'day-O', '2-O', ',-O', 'participants-O', 'also-O', 'attended-O', 'the-O', 'laboratory-O', 'to-O', 'complete-O', 'a-O', '20-O', ',-O', 'min-O', 'multitasking-O', 'stressor-O', '.-O']
['RESULTS-O', ':-O', 'Both-O', 'user-O', 'groups-O', 'exhibited-O', 'significantly-O', 'greater-O', 'levels-O', 'of-O', 'anxiety-B-Disease', 'and-O', 'depression-B-Disease', 'than-O', 'nonusers-O', '.-O']
['On-O', 'day-O', '1-O', ',-O', 'all-O', 'participants-O', 'exhibited-O', 'a-O', 'typical-O', 'cortisol-B-Chemical', 'profile-O', ',-O', 'though-O', 'light-O', 'users-O', 'had-O', 'significantly-O', 'elevated-O', 'levels-O', 'pre-O', ',-O', 'bed-O', '.-O']
['On-O', 'day-O', '2-O', ',-O', 'heavy-O', 'users-O', 'demonstrated-O', 'elevated-O', 'levels-O', 'upon-O', 'awakening-O', 'and-O', 'all-O', 'ecstasy-B-Chemical', ',-O', 'polydrug-O', 'users-O', 'demonstrated-O', 'elevated-O', 'pre-O', ',-O', 'bed-O', 'levels-O', 'compared-O', 'to-O', 'non-O', ',-O', 'users-O', '.-O']
['Significant-O', 'between-O', 'group-O', 'differences-O', 'were-O', 'also-O', 'observed-O', 'in-O', 'afternoon-O', 'cortisol-B-Chemical', 'levels-O', 'and-O', 'in-O', 'overall-O', 'cortisol-B-Chemical', 'secretion-O', 'across-O', 'the-O', 'day-O', '.-O']
['CONCLUSIONS-O', ':-O', 'The-O', 'increases-O', 'in-O', 'anxiety-B-Disease', 'and-O', 'depression-B-Disease', 'are-O', 'in-O', 'line-O', 'with-O', 'previous-O', 'observations-O', 'in-O', 'recreational-O', 'ecstasy-B-Chemical', ',-O', 'polydrug-O', 'users-O', '.-O']
['Dysregulated-O', 'diurnal-O', 'cortisol-B-Chemical', 'may-O', 'be-O', 'indicative-O', 'of-O', 'inappropriate-O', 'anticipation-O', 'of-O', 'forthcoming-O', 'demands-O', 'and-O', 'hypersecretion-O', 'may-O', 'lead-O', 'to-O', 'the-O', 'increased-O', 'psychological-O', 'and-O', 'physical-O', 'morbidity-O', 'associated-O', 'with-O', 'heavy-O', 'recreational-O', 'use-O', 'of-O', 'ecstasy-B-Chemical']
['Ifosfamide-B-Chemical', 'related-O', 'encephalopathy-B-Disease', ':-O', 'the-O', 'need-O', 'for-O', 'a-O', 'timely-O', 'EEG-O', 'evaluation-O', '.-O']
['BACKGROUND-O', ':-O', 'Ifosfamide-B-Chemical', 'is-O', 'an-O', 'alkylating-O', 'agent-O', 'useful-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'a-O', 'wide-O', 'range-O', 'of-O', 'cancers-B-Disease', 'including-O', 'sarcomas-I-Disease', ',-O', 'lymphoma-I-Disease', ',-O', 'gynecologic-O', 'and-O', 'testicular-O', 'cancers-I-Disease', '.-O']
['Encephalopathy-B-Disease', 'has-O', 'been-O', 'reported-O', 'in-O', '10-O', ',-O', '40-O', '%-O', 'of-O', 'patients-O', 'receiving-O', 'high-O', ',-O', 'dose-O', 'IV-O', 'ifosfamide-B-Chemical', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'highlight-O', 'the-O', 'role-O', 'of-O', 'electroencephalogram-O', '(-O', 'EEG-O', ')-O', 'in-O', 'the-O', 'early-O', 'detection-O', 'and-O', 'management-O', 'of-O', 'ifosfamide-B-Chemical', 'related-O', 'encephalopathy-B-Disease', '.-O']
['METHODS-O', ':-O', 'Retrospective-O', 'chart-O', 'review-O', 'including-O', 'clinical-O', 'data-O', 'and-O', 'EEG-O', 'recordings-O', 'was-O', 'done-O', 'on-O', 'five-O', 'patients-O', ',-O', 'admitted-O', 'to-O', 'MD-O', 'Anderson-O', 'Cancer-O', 'Center-O', 'between-O', 'years-O', '2009-O', 'and-O', '2012-O', ',-O', 'who-O', 'developed-O', 'ifosfamide-B-Chemical', 'related-O', 'acute-O', 'encephalopathy-B-Disease', '.-O']
['RESULTS-O', ':-O', 'All-O', 'five-O', 'patients-O', 'experienced-O', 'symptoms-O', 'of-O', 'encephalopathy-B-Disease', 'soon-O', 'after-O', '(-O', 'within-O', '12-O', 'h-O', ',-O', '2-O', 'days-O', ')-O', 'receiving-O', 'ifosfamide-B-Chemical', '.-O']
['Two-O', 'patients-O', 'developed-O', 'generalized-O', 'convulsions-B-Disease', 'while-O', 'one-O', 'patient-O', 'developed-O', 'continuous-O', 'non-convulsive-O', 'status-B-Disease', 'epilepticus-I-Disease', '(-O', 'NCSE-B-Disease', ')-O', 'that-O', 'required-O', 'ICU-O', 'admission-O', 'and-O', 'intubation-O', '.-O']
['Initial-O', 'EEG-O', 'showed-O', 'epileptiform-O', 'discharges-O', 'in-O', 'three-O', 'patients-O', ';-O', 'run-O', 'of-O', 'triphasic-O', 'waves-O', 'in-O', 'one-O', 'patient-O', 'and-O', 'moderate-O', 'degree-O', 'diffuse-O', 'generalized-O', 'slowing-O', '.-O']
['Mixed-O', 'pattern-O', 'with-O', 'the-O', 'presence-O', 'of-O', 'both-O', 'sharps-O', 'and-O', 'triphasic-O', 'waves-O', 'were-O', 'also-O', 'noted-O', '.-O']
['Repeat-O', 'EEGs-O', 'within-O', '24_h-O', 'of-O', 'symptom-O', 'onset-O', 'showed-O', 'marked-O', 'improvement-O', 'that-O', 'was-O', 'correlated-O', 'with-O', 'clinical-O', 'improvement-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Severity-O', 'of-O', 'ifosfamide-B-Chemical', 'related-O', 'encephalopathy-B-Disease', 'correlates-O', 'with-O', 'EEG-O', 'changes-O', '.-O']
['We-O', 'suggest-O', 'a-O', 'timely-O', 'EEG-O', 'evaluation-O', 'for-O', 'patients-O', 'receiving-O', 'ifosfamide-B-Chemical', 'who-O', 'develop-O', 'features-O', 'of-O', 'encephalopathy-B-Disease']
['Incidence-O', 'of-O', 'contrast-O', ',-O', 'induced-O', 'nephropathy-B-Disease', 'in-O', 'hospitalised-O', 'patients-O', 'with-O', 'cancer-B-Disease', '.-O']
['OBJECTIVES-O', ':-O', 'To-O', 'determine-O', 'the-O', 'frequency-O', 'of-O', 'and-O', 'possible-O', 'factors-O', 'related-O', 'to-O', 'contrast-O', ',-O', 'induced-O', 'nephropathy-B-Disease', '(-O', 'CIN-B-Disease', ')-O', 'in-O', 'hospitalised-O', 'patients-O', 'with-O', 'cancer-B-Disease', '.-O']
['METHODS-O', ':-O', 'Ninety-O', 'adult-O', 'patients-O', 'were-O', 'enrolled-O', '.-O']
['Patients-O', 'with-O', 'risk-O', 'factors-O', 'for-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'were-O', 'excluded-O', '.-O']
['Blood-O', 'samples-O', 'were-O', 'examined-O', 'the-O', 'day-O', 'before-O', 'contrast-O', ',-O', 'enhanced-O', 'computed-O', 'tomography-O', '(-O', 'CT-O', ')-O', 'and-O', 'serially-O', 'for-O', '3-O', 'days-O', 'thereafter-O', '.-O']
['CIN-B-Disease', 'was-O', 'defined-O', 'as-O', 'an-O', 'increase-O', 'in-O', 'serum-O', 'creatinine-B-Chemical', '(-O', 'Cr-B-Chemical', ')-O', 'of-O', '0-O', '.-O']
['5-O', 'mg-O', '/-O', 'dl-O', 'or-O', 'more-O', ',-O', 'or-O', 'elevation-O', 'of-O', 'Cr-B-Chemical', 'to-O', '25-O', '%-O', 'over-O', 'baseline-O', '.-O']
['Relationships-O', 'between-O', 'CIN-B-Disease', 'and-O', 'possible-O', 'risk-O', 'factors-O', 'were-O', 'investigated-O', '.-O']
['RESULTS-O', ':-O', 'CIN-B-Disease', 'was-O', 'detected-O', 'in-O', '18-O', '/-O', '90-O', '(-O', '20-O', ')-O', 'patients-O', '.-O']
['CIN-B-Disease', 'developed-O', 'in-O', '25-O', '.-O']
['5-O', '%-O', 'patients-O', 'who-O', 'underwent-O', 'chemotherapy-O', 'and-O', 'in-O', '11-O', '%-O', 'patients-O', 'who-O', 'did-O', 'not-O', '(-O', 'P-O', '=-O', '0-O', '.-O']
['1-O', ').-O', 'CIN-B-Disease', 'more-O', 'frequently-O', 'developed-O', 'in-O', 'patients-O', 'who-O', 'had-O', 'undergone-O', 'CT-O', 'within-O', '45-O', 'days-O', 'after-O', 'the-O', 'last-O', 'chemotherapy-O', '(-O', 'P-O', '=-O', '0-O', '.-O']
['005-O', ');-O', 'it-O', 'was-O', 'also-O', 'an-O', 'independent-O', 'risk-O', 'factor-O', '(-O', 'P-O', '=', '0-O', '.-O']
['017-O', ').-O', 'CIN-B-Disease', 'was-O', 'significantly-O', 'more-O', 'after-O', 'treatment-O', 'with-O', 'bevacizumab-B-Chemical', '/-O', 'irinotecan-B-Chemical', '(-O', 'P-O', '=-O', '0-O', '.-O']
['021-O', ')-O', 'and-O', 'in-O', 'patients-O', 'with-O', 'hypertension-B-Disease', '(-O', 'P-O', '=-O', '0-O', '.-O']
['044-O', ').-O', 'CONCLUSIONS-O', ':-O', 'The-O', 'incidence-O', 'of-O', 'CIN-B-Disease', 'after-O', 'CT-O', 'in-O', 'hospitalised-O', 'oncological-O', 'patients-O', 'was-O', '20-O', '.-O', 'CIN-B-Disease', 'developed-O', '4-O', '.-O']
['5-O', ',-O', 'times-O', 'more-O', 'frequently-O', 'in-O', 'patients-O', 'with-O', 'cancer-B-Disease', 'who-O', 'had-O', 'undergone-O', 'recent-O', 'chemotherapy-O', '.-O']
['Hypertension-B-Disease', 'and-O', 'the-O', 'combination-O', 'of-O', 'bevacizumab-B-Chemical', '/', 'irinotecan-B-Chemical', 'may-O', 'be-O', 'additional-O', 'risk-O', 'factors-O', 'for-O', 'CIN-B-Disease', 'development-O', '.-O']
['KEY-O', 'POINTS-O', ':-O', 'Contrast-O', ',-O', 'induced-O', 'nephropathy-B-Disease', '(-O', 'CIN-O', ')-O', 'is-O', 'a-O', 'concern-O', 'for-O', 'oncological-O', 'patients-O', 'undergoing-O', 'CT-O', '..-O', 'CIN-O', 'occurs-O', 'more-O', 'often-O', 'when-O', 'CT-O', 'is-O', 'performed-O', '<-O', '45-O', 'days-O', 'after-O', 'chemotherapy-O', '..-O', 'Hypertension-B-Disease', 'and-O', 'treatment-O', 'with-O', 'bevacizumab-B-Chemical']
['Syndrome-O', 'of-O', 'inappropriate-O', 'antidiuretic-O', 'hormone-O', 'secretion-O', 'associated-O', 'with-O', 'desvenlafaxine-B-Chemical', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'report-O', 'a-O', 'case-O', 'of-O', 'syndrome-O', 'of-O', 'inappropriate-O', 'anti-diuretic-O', 'hormone-O', '(-O', 'SIADH-B-Disease', ')-O', 'secretion-O', 'associated-O', 'with-O', 'desvenlafaxine-B-Chemical', '.-O']
['CASE-O', 'SUMMARY-O', ':-O', 'A-O', '57-O', ',-O', 'year-O', 'old-O', 'female-O', 'with-O', 'hyponatraemia-B-Disease', '.-O']
['Her-O', 'medications-O', 'included-O', 'desvenlafaxine-B-Chemical', ',-O', 'and-O', 'symptoms-O', 'included-O', 'nausea-B-Disease', ',-O', 'anxiety-B-Disease', 'and-O', 'confusion-B-Disease', '.-O']
['The-O', 'serum-O', 'sodium-B-Chemical', 'at-O', 'this-O', 'time-O', 'was-O', '120-O', 'mmol-O', '/-O', 'L-O', ',-O', 'serum-O', 'osmolality-O', 'was-O', '263-O', 'mosmol-O', '/-O', 'kg-O', ',-O', 'urine-O', 'osmolality-O', '410-O', 'mosmol-O', '/-O', 'kg-O', 'and-O', 'urine-O', 'sodium-B-Chemical', '63-O', 'mmol-O', '/-O', 'L-O', ',-O', 'consistent-O', 'with-O', 'a-O', 'diagnosis-O', 'of-O', 'SIADH-B-Disease', '.-O']
['Desvenlafaxine-B-Chemical', 'was-O', 'ceased-O', 'and-O', 'fluid-O', 'restriction-O', 'implemented-O', '.-O']
['After-O', '4-O', 'days-O', 'the-O', 'sodium-B-Chemical', 'increased-O', 'to-O', '128-O', 'mmol-O', '/-O', 'L-O', 'and-O', 'fluid-O', 'restriction-O', 'was-O', 'relaxed-O', '.-O']
['During-O', 'her-O', 'further-O', '3-O', 'weeks-O', 'inpatient-O', 'admission-O', 'the-O', 'serum-O', 'sodium-B-Chemical', 'ranged-O', 'from-O', '134-O', 'to-O', '137-O', 'mmol-O', '/-O', 'L-O', 'during-O', 'treatment-O', 'with-O', 'mirtazapine-B-Chemical', '.-O']
['DISCUSSION-O', ':-O', 'SIADH-B-Disease', 'has-O', 'been-O', 'widely-O', 'reported-O', 'with-O', 'a-O', 'range-O', 'of-O', 'antidepressants-B-Chemical', '.-O']
['This-O', 'case-O', 'report-O', 'suggests-O', 'that-O', 'desvenlafaxine-B-Chemical', 'might-O', 'cause-O', 'clinically-O', 'significant-O', 'hyponatremia-B-Disease', '.-O']
['CONCLUSIONS-O', ':-O', 'Clinicians-O', 'should-O', 'be-O', 'aware-O', 'of-O', 'the-O', 'potential-O', 'for-O', 'antidepressants-B-Chemical', 'to-O', 'cause-O', 'hyponatremia-B-Disease']
['Oxidative-O', 'stress-O', 'on-O', 'cardiotoxicity-B-Disease', 'after-O', 'treatment-O', 'with-O', 'single-O', 'and-O', 'multiple-O', 'doses-O', 'of-O', 'doxorubicin-B-Chemical', '.-O']
['The-O', 'mechanism-O', 'of-O', 'doxorubicin-B-Chemical', '(-O', 'DOX-B-Chemical', ')-O', 'induced-O', 'cardiotoxicity-B-Disease', 'remains-O', 'controversial-O', '.-O']
['Wistar-O', 'rats-O', '(-O', 'n-O', '=', '66-O', ')-O', 'received-O', 'DOX-Chemical', 'injections-O', 'intraperitoneally-O', 'and-O', 'were-O', 'randomly-O', 'assigned-O', 'to-O', '2-O', 'experimental-O', 'protocols-O', ':-O', '(1-O', ')-O', 'rats-O', 'were-O', 'killed-O', 'before-O', '(-O', '24-O', 'h-O', ',-O', 'n-O', '=', '8-O', ')-O', 'and-O', '24-O', 'h-O', 'after-O', '(+-O', '24-O', 'h-O', ',-O', 'n-O', '=', '8-O', ')-O', 'a-O', 'single-O', 'dose-O', 'of-O', 'DOX-Chemical', '(-O', '4-O', 'mg-O', '/-O', 'kg-O', 'body-O', 'weight-O', ')-O', 'to-O', 'determine-O', 'the-O', 'DOX-Chemical', 'acute-O', 'effect-O', 'and-O', '(2-O', ')-O', 'rats-O', '(-O', 'n-O', '=', '58-O', ')-O', 'received-O', '4-O', 'injections-O', 'of-O', 'DOX-Chemical', '(-O', '4-O', 'mg-O', '/-O', 'kg-O', 'body-O', 'weight-O', '/-O', 'week-O', ')-O', 'and-O', 'were-O', 'killed-O', 'before-O', 'the-O', 'first-O', 'injection-O', '(-O', 'M0-O', ')-O', 'and-O', '1-O', 'week-O', 'after-O', 'each-O', 'injection-O', '(-O', 'M1-O', ',-O', 'M2-O', ',-O', 'M3-O', ',-O', 'and-O', 'M4-O', ')-O', 'to-O', 'determine-O', 'the-O', 'chronological-O', 'effects-O', '.-O']
['Animals-O', 'used-O', 'at-O', 'M0-O', '(-O', 'n-O', '=O', '8-O', ')-O', 'were-O', 'also-O', 'used-O', 'at-O', 'moment-O', ',-O', '24-O', 'h-O', 'of-O', 'acute-O', 'study-O', '.-O']
['Cardiac-O', 'total-O', 'antioxidant-O', 'performance-O', '(-O', 'TAP-O', '),', 'DNA-O', 'damage-O', ',-O', 'and-O', 'morphology-O', 'analyses-O', 'were-O', 'carried-O', 'out-O', 'at-O', 'each-O', 'time-O', 'point-O', '.-O']
['Single-O', 'dose-O', 'of-O', 'DOX-B-Chemical', 'was-O', 'associated-O', 'with-O', 'increased-O', 'cardiac-B-Disease', 'disarrangement-O', ',-O', 'necrosis-B-Disease', ',-O', 'and-O', 'DNA-O', 'damage-O', '(-O', 'strand-O', 'breaks-O', '(-O', 'SBs-O', ')-O', 'and-O', 'oxidized-O', 'pyrimidines-O', ')-O', 'and-O', 'decreased-O', 'TAP-O', '.-O']
['The-O', 'chronological-O', 'study-O', 'showed-O', 'an-O', 'effect-O', 'of-O', 'a-O', 'cumulative-O', 'dose-O', 'on-O', 'body-O', 'weight-O', '(-O', 'R-O', '=', '0-O', '.-O']
['99-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['011-O', ')-O', 'necrosis-B-Disease', '(-O', 'R-O', '=O', '1-O', '.-O']
['00-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['004-O', '),-O', 'TAP-O', '(-O', 'R-O', '=-O', '0-O', '.-O']
['95-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['049-O', ')-O', 'and-O', 'DNA-O', 'SBs-O', '(-O', 'R-O', '=', '0-O', '.-O']
['95-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['049-O', ').-O', 'DNA-O', 'SBs-O', 'damage-O', 'was-O', 'negatively-O', 'associated-O', 'with-O', 'TAP-B-Chemical', '(-O', 'R-O', '=-O', '0-O', ').-O']
['98-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['018-O', ')-O', 'and-O', 'necrosis-B-Disease', '(-O', 'R-O', '=O', '0-O', '.-O']
['97-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['027-O', ').-O', 'Our-O', 'results-O', 'suggest-O', 'that-O', 'oxidative-O', 'damage-O', 'is-O', 'associated-O', 'with-O', 'acute-B-Disease', 'cardiotoxicity-I-Disease', 'induced-O', 'by-O', 'a-O', 'single-O', 'dose-O', 'of-O', 'DOX-B-Chemical', 'only-O', '.-O']
['Increased-O', 'resistance-O', 'to-O', 'the-O', 'oxidative-O', 'stress-O', 'is-O', 'plausible-O', 'for-O', 'the-O', 'multiple-O', 'dose-O', 'of-O', 'DOX-B-Chemical', '.-O']
['Thus-O', ',-O', 'different-O', 'mechanisms-O', 'may-O', 'be-O', 'involved-O', 'in-O', 'acute-O', 'toxicity-B-Disease', 'versus-O', 'chronic-O', 'toxicity-B-Disease']
['Tacrolimus-B-Chemical', ',-O', 'related-O', 'seizure-B-Disease', 'after-O', 'pediatric-O', 'liver-O', 'transplantation-O', '--O', 'a-O', 'single-O', ',-O', 'center-O', 'experience-O', '.-O']
['To-O', 'identify-O', 'the-O', 'risk-O', 'factors-O', 'for-O', 'new-O', 'onset-O', 'seizures-B-Disease', 'after-O', 'pediatric-O', 'LT-O', 'and-O', 'to-O', 'assess-O', 'their-O', 'clinical-O', 'implications-O', 'and-O', 'long-O', '--O', 'term-O', 'prognosis-O', '.-O']
['The-O', 'clinical-O', 'and-O', 'laboratory-O', 'data-O', 'of-O', '27-O', 'consecutive-O', 'children-O', 'who-O', 'underwent-O', 'LT-O', 'from-O', 'January-O', '2007-O', 'to-O', 'December-O', '2010-O', 'in-O', 'our-O', 'center-O', 'were-O', 'analyzed-O', 'retrospectively-O', '.-O']
['Patients-O', 'were-O', 'divided-O', 'into-O', 'seizures-B-Disease', 'group-O', 'and-O', 'a-O', 'non-O', ',-O', 'seizures-B-Disease', 'group-O', '.-O']
['Pre-O', ',-O', 'operative-O', ',-O', 'intra-O', ',-O', 'operative-O', ',-O', 'and-O', 'post-O', ',-O', 'operative-O', 'data-O', 'were-O', 'collected-O', '.-O']
['Seizures-B-Disease', 'occurred-O', 'in-O', 'four-O', 'children-O', ',-O', 'an-O', 'incidence-O', 'of-O', '14-O', '.-O']
['8-O', '.-O', 'All-O', 'exhibited-O', 'generalized-O', 'tonic-clonic-B-Disease', 'seizures-I-Disease', 'within-O', 'the-O', 'first-O', 'two-O', 'wk-O', 'after-O', 'LT-O', '.-O']
['Univariate-O', 'analysis-O', 'showed-O', 'that-O', 'the-O', 'risk-O', 'factors-O', 'associated-O', 'with-O', 'seizures-B-Disease', 'after-O', 'pediatric-O', 'LT-O', 'included-O', 'gender-O', ',-O', 'pediatric-O', 'end-stage-B-Disease', 'liver-O', 'disease-I-Disease', 'score-O', 'before-O', 'surgery-O', ',-O', 'Child-O', ',-O', 'Pugh-O', 'score-O', 'before-O', 'surgery-O', ',-O', 'serum-O', 'total-O', 'bilirubin-B-Chemical', 'after-O', 'surgery-O', ',-O', 'and-O', 'trough-O', 'TAC-B-Chemical', 'level-O', '.-O']
['Multivariate-O', 'analysis-O', 'showed-O', 'that-O', 'trough-O', 'TAC-B-Chemical', 'level-O', 'was-O', 'the-O', 'only-O', 'independent-O', 'risk-O', 'factor-O', 'associated-O', 'with-O', 'the-O', 'seizures-B-Disease', '.-O']
['All-O', 'children-O', 'who-O', 'experienced-O', 'seizures-B-Disease', 'survived-O', 'with-O', 'good-O', 'graft-O', 'function-O', 'and-O', 'remained-O', 'seizure-B-Disease', ',-O', 'free-O', 'without-O', 'anti-O', ',-O', 'epileptic-B-Disease', 'drugs-O', 'over-O', 'a-O', 'mean-O', 'follow-O', ',-O', 'up-O', 'period-O', 'of-O', '33-O', '.-O']
['7-O', '+-O', '14-O', '.-O']
['6-O', 'months-O', '.-O']
['High-O', 'trough-O', 'TAC-B-Chemical', 'level-O', 'was-O', 'the-O', 'predominant-O', 'factor-O', 'that-O', 'contributed-O', 'to-O', 'seizures-B-Disease', 'in-O', 'the-O', 'early-O', 'post-O', ',', 'operative-O', 'period-O', 'after-O', 'pediatric-O', 'LT-O', '.-O']
['High-O', 'PELD-O', 'and-O', 'Child-O', ',-O', 'Pugh-O', 'scores-O', 'before-O', 'LT-O', 'and-O', 'high-O', 'post-O', ',-O', 'operative-O', 'serum-O', 'Tbil-O', 'may-O', 'be-O', 'contributory-O', 'risk-O', 'factors-O', 'for-O', 'TAC-B-Chemical', ',-O', 'related-O', 'seizures-B-Disease']
['The-O', 'flavonoid-O', 'apigenin-B-Chemical', 'delays-O', 'forgetting-O', 'of-O', 'passive-O', 'avoidance-O', 'conditioning-O', 'in-O', 'rats-O', '.-O']
['The-O', 'present-O', 'experiments-O', 'were-O', 'performed-O', 'to-O', 'study-O', 'the-O', 'effect-O', 'of-O', 'the-O', 'flavonoid-O', 'apigenin-B-Chemical', '(-O', '20-O', 'mg-O', '/-O', 'kg-O', 'intraperitoneally-O', '(-O', 'i-O', '.-O']
['p-O', ')-O', '1-O', 'h-O', 'before-O', 'acquisition-O', ')-O', 'on-O', '24-O', 'h-O', 'retention-O', 'performance-O', 'and-O', 'forgetting-O', 'of-O', 'a-O', 'step-O', ',-O', 'through-O', 'passive-O', 'avoidance-O', 'task-O', ',-O', 'in-O', 'young-O', 'male-O', 'Wistar-O', 'rats-O', '.-O']
['There-O', 'were-O', 'no-O', 'differences-O', 'between-O', 'saline-O', ',-O', 'and-O', 'apigenin-B-Chemical', ',-O', 'treated-O', 'groups-O', 'in-O', 'the-O', '24-O', 'h-O', 'retention-O', 'trial-O', '.-O']
['Furthermore-O', ',-O', 'apigenin-B-Chemical', 'did-O', 'not-O', 'prevent-O', 'the-O', 'amnesia-B-Disease', 'induced-O', 'by-O', 'scopolamine-B-Chemical', '(-O', '1mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', '.,-O', '30-O', 'min-O', 'before-O', 'the-O', 'acquisition-O', ').-O', 'The-O', 'saline-O', ',-O', 'and-O', 'apigenin-B-Chemical', ',-O', 'treated-O', 'rats-O', 'that-O', 'did-O', 'not-O', 'step-O', 'through-O', 'into-O', 'the-O', 'dark-O', 'compartment-O', 'during-O', 'the-O', 'cut-O', ',-O', 'off-O', 'time-O', '(-O', '540-O', 's-O', ')-O', 'were-O', 'retested-O', 'weekly-O', 'for-O', 'up-O', 'to-O', 'eight-O', 'weeks-O', '.-O']
['In-O', 'the-O', 'saline-O', 'treated-O', 'group-O', ',-O', 'the-O', 'first-O', 'significant-O', 'decline-O', 'in-O', 'passive-O', 'avoidance-O', 'response-O', 'was-O', 'observed-O', 'at-O', 'four-O', 'weeks-O', ',-O', 'and-O', 'complete-O', 'memory-O', 'loss-O', 'was-O', 'found-O', 'five-O', 'weeks-O', 'after-O', 'the-O', 'acquisition-O', 'of-O', 'the-O', 'passive-O', 'avoidance-O', 'task-O', '.-O']
['At-O', 'the-O', 'end-O', 'of-O', 'the-O', 'experimental-O', 'period-O', ',-O', '60-O', '%-O', 'of-O', 'the-O', 'animals-O', 'treated-O', 'with-O', 'apigenin-B-Chemical', 'still-O', 'did-O', 'not-O', 'step-O', 'through-O', '.-O']
['These-O', 'data-O', 'suggest-O', 'that-O', '1-O', ')-O', 'apigenin-B-Chemical', 'delays-O', 'the-O', 'long-O', ',-O', 'term-O', 'forgetting-O', 'but-O', 'did-O', 'not-O', 'modulate-O', 'the-O', '24-O', 'h-O', 'retention-O', 'of-O', 'fear-O', 'memory-O', 'and-O', '2-O', ')-O', 'the-O', 'obtained-O', 'beneficial-O', 'effect-O', 'of-O', 'apigenin-B-Chemical']
['Cholecystokinin-octapeptide-B-Chemical', 'restored-O', 'morphine-B-Chemical', ',-O', 'induced-O', 'hippocampal-O', 'long-O', ',-O', 'term-O', 'potentiation-O', 'impairment-O', 'in-O', 'rats-O', '.-O']
['Cholecystokinin-octapeptide-B-Chemical', '(-O', 'CCK-8-B-Chemical', ')-O', 'which-O', 'is-O', 'a-O', 'typical-O', 'brain-O', '-O', 'gut-O', 'peptide-O', '-O', 'exerts-O', 'a-O', 'wide-O', 'range-O', 'of-O', 'biological-O', 'activities-O', 'on-O', 'the-O', 'central-O', 'nervous-O', 'system-O', '.-O']
['We-O', 'have-O', 'previously-O', 'reported-O', 'that-O', 'CCK-8-B-Chemical', 'significantly-O', 'alleviated-O', 'morphine-B-Chemical', ',-O', 'induced-O', 'amnesia-B-Disease', 'and-O', 'reversed-O', 'spine-O', 'density-O', 'decreases-O', 'in-O', 'the-O', 'CA1-O', 'region-O', 'of-O', 'the-O', 'hippocampus-O', 'in-O', 'morphine-B-Chemical', ',-O', 'treated-O', 'animals-O', '.-O']
['Here-O', ',-O', 'we-O', 'investigated-O', 'the-O', 'effects-O', 'of-O', 'CCK-8-B-Chemical', 'on-O', 'long-O', ',-O', 'term-O', 'potentiation-O', '(-O', 'LTP-O', ')-O', 'in-O', 'the-O', 'lateral-O', 'perforant-O', 'path-O', '(-O', 'LPP-O', ')-O', 'granule-O', 'cell-O', 'synapse-O', 'of-O', 'rat-O', 'dentate-O', 'gyrus-O', '(-O', 'DG-O', ')-O', 'in-O', 'acute-O', 'saline-O', 'or-O', 'morphine-B-Chemical', ',-O', 'treated-O', 'rats-O', '.-O']
['Population-O', 'spikes-O', '(-O', 'PS-O', ')-O', 'which-O', 'were-O', 'evoked-O', 'by-O', 'stimulation-O', 'of-O', 'the-O', 'LPP-O', ',-O', 'were-O', 'recorded-O', 'in-O', 'the-O', 'DG-O', 'region-O', '.-O']
['Acute-O', 'morphine-B-Chemical', '(-O', '30mg-O', '/-O', 'kg-O', ',-O', 's-O', '.-O']
['c-O', ')-O', 'treatment-O', 'significantly-O', 'attenuated-O', 'hippocampal-O', 'LTP-O', 'and-O', 'CCK-8-B-Chemical', '(-O', '1ug-O', ',-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ')-O', 'restored-O', 'the-O', 'amplitude-O', 'of-O', 'PS-O', 'that-O', 'was-O', 'attenuated-O', 'by-O', 'morphine-B-Chemical', 'injection-O', '.-O']
['Furthermore-O', ',-O', 'microinjection-O', 'of-O', 'CCK-8-B-Chemical', '(-O', '0-O', '.-O']
['1-O', 'and-O', '1ug-O', ',-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ')-O', 'also-O', 'significantly-O', 'augmented-O', 'hippocampal-O', 'LTP-O', 'in-O', 'saline-O', ',-O', 'treated-O', '(-O', '1ml-O', '/-O', 'kg-O', ',-O', 's-O', '.-O']
['c-O', ')-O', 'rats-O', '.-O']
['Pre-O', ',-O', 'treatment-O', 'of-O', 'the-O', 'CCK2-O', 'receptor-O', 'antagonist-O', 'L-O', ',', '365-O', ',', '260-O', '(-O', '10ug-O', ',-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ')-O', 'reversed-O', 'the-O', 'effects-O', 'of-O', 'CCK-8-B-Chemical', ',-O', 'but-O', 'the-O', 'CCK1-O', 'receptor-O', 'antagonist-O', 'L-O', ',', '364-O', ',', '718-O', '(-O', '10ug-O', ',', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ')-O', 'did-O', 'not-O', '.-O']
['The-O', 'present-O', 'results-O', 'demonstrate-O', 'that-O', 'CCK-8-B-Chemical', 'attenuates-O', 'the-O', 'effect-O', 'of-O', 'morphine-B-Chemical', 'on-O', 'hippocampal-O', 'LTP-O', 'through-O', 'CCK2-B-Chemical', 'receptors-O', 'and-O', 'suggest-O', 'an-O', 'ameliorative-O', 'function-O', 'of-O', 'CCK-8-B-Chemical', 'on-O', 'morphine-B-Chemical', ',-O', 'induced-O', 'memory-B-Disease', 'impairment-I-Disease']
['Glial-O', 'activation-O', 'and-O', 'post-O', ',-O', 'synaptic-O', 'neurotoxicity-O', ':-O', 'the-O', 'key-O', 'events-O', 'in-O', 'Streptozotocin-B-Chemical', '(-O', 'ICV-O', ')-O', 'induced-O', 'memory-B-Disease', 'impairment-I-Disease', 'in-O', 'rats-O', '.-O']
['In-O', 'the-O', 'present-O', 'study-O', 'the-O', 'role-O', 'of-O', 'glial-O', 'activation-O', 'and-O', 'post-O', 'synaptic-O', 'toxicity-O', 'in-O', 'ICV-O', 'Streptozotocin-B-Chemical', '(-O', 'STZ-B-Chemical', ')-O', 'induced-O', 'memory-O', 'impaired-O', 'rats-O', 'was-O', 'explored-O', '.-O']
['In-O', 'experiment-O', 'set-O', 'up-O', '1-O', ':-O', 'Memory-O', 'deficit-B-Disease', 'was-O', 'found-O', 'in-O', 'Morris-O', 'water-O', 'maze-O', 'test-O', 'on-O', '14-O', ',-O', '16-O', 'days-O', 'after-O', 'STZ-B-Chemical', '(-O', 'ICV-O', ';-O', '3mg-O', '/-O', 'Kg-O', ')-O', 'administration-O', '.-O']
['STZ-B-Chemical', 'causes-O', 'increased-O', 'expression-O', 'of-O', 'GFAP-O', ',-O', 'CD11b-O', 'and-O', 'TNF-B-Chemical', ',-O', 'a-O', 'indicating-O', 'glial-O', 'activation-O', 'and-O', 'neuroinflammation-B-Disease', '.-O']
['STZ-B-Chemical', 'also-O', 'significantly-O', 'increased-O', 'the-O', 'level-O', 'of-O', 'ROS-B-Chemical', ',-O', 'nitrite-B-Chemical', ',-O', 'Ca-B-Chemical', '(-O', '2-O', ')-O', 'and-O', 'reduced-O', 'the-O', 'mitochondrial-O', 'activity-O', 'in-O', 'synaptosomal-O', 'preparation-O', 'illustrating-O', 'free-O', 'radical-O', 'generation-O', 'and-O', 'excitotoxicity-O', '.-O']
['Increased-O', 'expression-O', 'and-O', 'activity-O', 'of-O', 'Caspase-O', ',-O', '3-O', 'was-O', 'also-O', 'observed-O', 'in-O', 'STZ-B-Chemical', 'treated-O', 'rat-O', 'which-O', 'specify-O', 'apoptotic-O', 'cell-O', 'death-O', 'in-O', 'hippocampus-O', 'and-O', 'cortex-O', '.-O']
['STZ-B-Chemical', 'treatment-O', 'showed-O', 'decrease-O', 'expression-O', 'of-O', 'post-O', 'synaptic-O', 'markers-O', 'CaMKIIa-O', 'and-O', 'PSD-O', ',-O', '95-O', ',-O', 'while-O', ',-O', 'expression-O', 'of-O', 'pre-O', 'synaptic-O', 'markers-O', '(-O', 'synaptophysin-O', 'and-O', 'SNAP-O', ',-O', '25-O', ')-O', 'remains-O', 'unaltered-O', 'indicating-O', 'selective-O', 'post-O', 'synaptic-O', 'neurotoxicity-O', '.-O']
['Oral-O', 'treatment-O', 'with-O', 'Memantine-B-Chemical', '(-O', '10mg-O', '/-O', 'kg-O', ')-O', 'and-O', 'Ibuprofen-B-Chemical', '(-O', '50-O', 'mg-O', '/-O', 'kg-O', ')-O', 'daily-O', 'for-O', '13-O', 'days-O', 'attenuated-O', 'STZ-B-Chemical', 'induced-O', 'glial-O', 'activation-O', ',-O', 'apoptotic-O', 'cell-O', 'death-O', 'and-O', 'post-O', 'synaptic-O', 'neurotoxicity-O', 'in-O', 'rat-O', 'brain-O', '.-O']
['Further-O', ',-O', 'in-O', 'experiment-O', 'set-O', 'up-O', '2-O', ':-O', 'where-O', 'memory-O', 'function-O', 'was-O', 'not-O', 'affected-O', 'i-O', '.-O']
['e-O', '.-O']
['7-O', ',-O', '9-O', 'days-O', 'after-O', 'STZ-B-Chemical', 'treatment-O', '.-O']
['The-O', 'level-O', 'of-O', 'GFAP-B-Chemical', ',-O', 'CD11b-B-Chemical', ',-O', 'TNF-B-Chemical', ',-O', 'a-O', 'ROS-B-Chemical', 'and-O', 'nitrite-B-Chemical', 'levels-O', 'were-O', 'increased-O', '.-O']
['On-O', 'the-O', 'other-O', 'hand-O', ',-O', 'apoptotic-O', 'marker-O', ',-O', 'synaptic-O', 'markers-O', ',-O', 'mitochondrial-O', 'activity-O', 'and-O', 'Ca-B-Chemical', '(-O', '2-O', ')-O', 'levels-O', 'remained-O', 'unaffected-O', '.-O']
['Collective-O', 'data-O', 'indicates-O', 'that-O', 'neuroinflammatory-O', 'process-O', 'and-O', 'oxidative-O', 'stress-O', 'occurs-O', 'earlier-O', 'to-O', 'apoptosis-O', 'and-O', 'does-O', 'not-O', 'affect-O', 'memory-O', 'function-O', '.-O']
['Present-O', 'study-O', 'clearly-O', 'suggests-O', 'that-O', 'glial-O', 'activation-O', 'and-O', 'post-O', 'synaptic-O', 'neurotoxicity-B-Disease', 'are-O', 'the-O', 'key-O', 'factors-O', 'in-O', 'STZ-B-Chemical', 'induced-O', 'memory-B-Disease', 'impairment-I-Disease']
['Comparison-O', 'of-O', 'effects-O', 'of-O', 'isotonic-O', 'sodium-B-Chemical', 'chloride-I-Chemical', 'with-O', 'diltiazem-B-Chemical', 'in-O', 'prevention-O', 'of-O', 'contrast-O', ',-O', 'induced-O', 'nephropathy-B-Disease', '.-O']
['INTRODUCTION-O', 'AND-O', 'OBJECTIVE-O', ':-O', 'Contrast-O', ',-O', 'induced-O', 'nephropathy-B-Disease', '(-O', 'CIN-O', ')', 'significantly-O', 'increases-O', 'the-O', 'morbidity-O', 'and-O', 'mortality-O', 'of-O', 'patients-O', '.-O']
['The-O', 'aim-O', 'of-O', 'this-O', 'study-O', 'is-O', 'to-O', 'investigate-O', 'and-O', 'compare-O', 'the-O', 'protective-O', 'effects-O', 'of-O', 'isotonic-O', 'sodium-B-Chemical', 'chloride-I-Chemical', 'with-O', 'sodium-B-Chemical', 'bicarbonate-I-Chemical', 'infusion-O', 'and-O', 'isotonic-O', 'sodium-B-Chemical', 'chloride-I-Chemical', 'infusion-O', 'with-O', 'diltiazem-B-Chemical', ',-O', 'a-O', 'calcium-B-Chemical', 'channel-O', 'blocker-O', ',-O', 'in-O', 'preventing-O', 'CIN-B-Disease', '.-O']
['MATERIALS-O', 'AND-O', 'METHODS-O', ':-O', 'Our-O', 'study-O', 'included-O', 'patients-O', 'who-O', 'were-O', 'administered-O', '30-O', ',-O', '60-O', 'mL-O', 'of-O', 'iodinated-B-Chemical', 'contrast-O', 'agent-O', 'for-O', 'percutaneous-O', 'coronary-O', 'angiography-O', '(-O', 'PCAG-O', ')-O', 'all-O', 'with-O', 'creatinine-B-Chemical', 'values-O', 'between-O', '1-O', '.-O']
['1-O', 'and-O', '3-O', '.-O']
['1-O', 'mg-O', '/-O', 'dL-O', '.-O']
['Patients-O', 'were-O', 'divided-O', 'into-O', 'three-O', 'groups-O', 'and-O', 'each-O', 'group-O', 'had-O', '20-O', 'patients-O', '.-O']
['The-O', 'first-O', 'group-O', 'of-O', 'patients-O', 'was-O', 'administered-O', 'isotonic-O', 'sodium-B-Chemical', 'chloride-I-Chemical', ';-O', 'the-O', 'second-O', 'group-O', 'was-O', 'administered-O', 'a-O', 'solution-O', 'that-O', 'of-O', '5-O', '%-O', 'dextrose-B-Chemical', 'and-O', 'sodium-B-Chemical', 'bicarbonate-I-Chemical', ',-O', 'while-O', 'the-O', 'third-O', 'group-O', 'was-O', 'administered-O', 'isotonic-O', 'sodium-B-Chemical', 'chloride-I-Chemical', 'before-O', 'and-O', 'after-O', 'the-O', 'contrast-O', 'injection-O', '.-O']
['The-O', 'third-O', 'group-O', 'received-O', 'an-O', 'additional-O', 'injection-O', 'of-O', 'diltiazem-B-Chemical', 'the-O', 'day-O', 'before-O', 'and-O', 'first-O', '2-O', 'days-O', 'after-O', 'the-O', 'contrast-O', 'injection-O', '.-O']
['All-O', 'of-O', 'the-O', 'patients-O', 'x-O', 'plasma-O', 'blood-O', 'urea-B-Chemical', 'nitrogen-O', '(-O', 'BUN-O', ')-O', 'and-O', 'creatinine-B-Chemical', 'levels-O', 'were-O', 'measured-O', 'on-O', 'the-O', 'second-O', 'and-O', 'seventh-O', 'day-O', 'after-O', 'the-O', 'administration-O', 'of-O', 'intravenous-O', 'contrast-O', 'material-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'basal-O', 'creatinine-B-Chemical', 'levels-O', 'were-O', 'similar-O', 'for-O', 'all-O', 'three-O', 'groups-O', '(-O', 'p-O', '>O', '0-O', '.-O']
['05-O', ').-O', 'Among-O', 'a-O', 'total-O', 'of-O', '60-O', 'patients-O', 'included-O', 'in-O', 'the-O', 'study-O', ',-O', '16-O', 'patients-O', 'developed-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', '(-O', 'ARF-B-Disease', ')-O', 'on-O', 'the-O', 'second-O', 'day-O', 'after-O', 'contrast-O', 'material-O', 'was-O', 'injected-O', '(-O', '26-O', '.-O']
['6-O', ').-O', 'The-O', 'number-O', 'of-O', 'patients-O', 'who-O', 'developed-O', 'ARF-B-Disease', 'on-O', 'the-O', 'second-O', 'day-O', 'after-O', 'the-O', 'injection-O', 'in-O', 'the-O', 'first-O', 'group-O', 'was-O', 'five-O', '(-O', '25-O', ')-O', 'in-O', 'the-O', 'second-O', 'group-O', 'was-O', 'six-O', '(-O', '30-O', ')-O', 'and-O', 'the-O', 'third-O', 'group-O', 'was-O', 'five-O', '(-O', '25-O', ')-O', '(-O', 'p-O', '>-O', '0-O', '.-O']
['05-O', ').-O', 'CONCLUSION-O', ':-O', 'There-O', 'was-O', 'no-O', 'significant-O', 'difference-O', 'between-O', 'isotonic-O', 'sodium-B-Chemical', 'chloride-I-Chemical', ',-O', 'sodium-B-Chemical', 'bicarbonate-I-Chemical', 'and-O', 'isotonic-O', 'sodium-B-Chemical', 'chloride-I-Chemical', 'with-O', 'diltiazem-B-Chemical']
['Neurocognitive-O', 'and-O', 'neuroradiologic-O', 'central-O', 'nervous-O', 'system-O', 'late-O', 'effects-O', 'in-O', 'children-O', 'treated-O', 'on-O', 'Pediatric-O', 'Oncology-O', 'Group-O', '(-O', 'POG-O', ')-O', 'P9605-O', '(-O', 'standard-O', 'risk-O', ')-O', 'and-O', 'P9201-O', '(-O', 'lesser-O', 'risk-O', ')-O', 'acute-O', 'lymphoblastic-O', 'leukemia-I-Disease', 'protocols-O', '(-O', 'ACCL0131-O', '):-O', 'a-O', 'methotrexate-B-Chemical', 'consequence-O', '?-O', 'A-O', 'report-O', 'from-O', 'the-O', 'Children-O', 'x-O', 's-O', 'Oncology-O', 'Group-O', '.-O']
['Concerns-O', 'about-O', 'long-O', ',-O', 'term-O', 'methotrexate-B-Chemical', '(-O', 'MTX-B-Chemical', ')-O', 'neurotoxicity-O', 'in-O', 'the-O', '1990s-O', 'led-O', 'to-O', 'modifications-O', 'in-O', 'intrathecal-O', '(-O', 'IT-O', ')-O', 'therapy-O', ',-O', 'leucovorin-B-Chemical', 'rescue-O', ',-O', 'and-O', 'frequency-O', 'of-O', 'systemic-O', 'MTX-B-Chemical', 'administration-O', 'in-O', 'children-O', 'with-O', 'acute-B-Disease', 'lymphoblastic-I-Disease', 'leukemia-I-Disease', '.-O']
['In-O', 'this-O', 'study-O', ',-O', 'neurocognitive-O', 'outcomes-O', 'and-O', 'neuroradiologic-O', 'evidence-O', 'of-O', 'leukoencephalopathy-B-Disease', 'were-O', 'compared-O', 'in-O', 'children-O', 'treated-O', 'with-O', 'intense-O', 'central-O', 'nervous-O', 'system-O', '(-O', 'CNS-O', ')-O', 'directed-O', 'therapy-O', '(-O', 'P9605-O', ')-O', 'versus-O', 'those-O', 'receiving-O', 'fewer-O', 'CNS-O', ',-O', 'directed-O', 'treatment-O', 'days-O', 'during-O', 'intensive-O', 'consolidation-O', '(-O', 'P9201-O', ')-O', '.-O', 'A-O', 'total-O', 'of-O', '66-O', 'children-O', 'from-O', '16-O', 'Pediatric-O', 'Oncology-O', 'Group-O', 'institutions-O', 'with-O', 'x-O', 'standard-O', ',-O', 'risk-O', 'x-O', 'acute-B-Disease', 'lymphoblastic-O', 'leukemia-O', ',-O', '1-O', '.-O']
['00-O', 'to-O', '9-O', '.-O']
['99-O', 'years-O', 'at-O', 'diagnosis-O', ',-O', 'without-O', 'evidence-O', 'of-O', 'CNS-O', 'leukemia-B-Disease', 'at-O', 'diagnosis-O', 'were-O', 'enrolled-O', 'on-O', 'ACCL0131-O', ':-O', '28-O', 'from-O', 'P9201-O', 'and-O', '38-O', 'from-O', 'P9605-O', '.-O']
['Magnetic-O', 'resonance-O', 'imaging-O', 'scans-O', 'and-O', 'standard-O', 'neuropsychological-O', 'tests-O', 'were-O', 'performed-O', '>-O', '2-O', '.-O']
['6-O', 'years-O', 'after-O', 'the-O', 'end-O', 'of-O', 'treatment-O', '.-O']
['Significantly-O', 'more-O', 'P9605-O', 'patients-O', 'developed-O', 'leukoencephalopathy-B-Disease', 'compared-O', 'with-O', 'P9201-O', 'patients-O', '(-O', '68-O', ',-O', '95-O', '%-O', 'confidence-O', 'interval-O', '49-O', '%-O', '83-O', '%-O', 'vs-O', '.-O']
['22-O', ',-O', '95-O', '%-O', 'confidence-O', 'interval-O', '5-O', '%-O', '44-O', ';-O', 'P-O', '=-O', '0-O', '.-O']
['001-O', ')-O', 'identified-O', 'as-O', 'late-O', 'as-O', '7-O', '.-O']
['7-O', 'years-O', 'after-O', 'the-O', 'end-O', 'of-O', 'treatment-O', '.-O']
['Overall-O', ',-O', '40-O', '%-O', 'of-O', 'patients-O', 'scored-O', '<-O', '85-O', 'on-O', 'either-O', 'Verbal-O', 'or-O', 'Performance-O', 'IQ-O', '.-O']
['Children-O', 'on-O', 'both-O', 'studies-O', 'had-O', 'significant-O', 'attention-O', 'problems-O', ',-O', 'but-O', 'P9605-O', 'children-O', 'scored-O', 'below-O', 'average-O', 'on-O', 'more-O', 'neurocognitive-O', 'measures-O', 'than-O', 'those-O', 'treated-O', 'on-O', 'P9201-O', '(-O', '82-O', ',-O', '14-O', '/', '17-O', 'measures-O', 'vs-O', '.-O']
['24-O', ',-O', '4-O', '/-O', '17-O', 'measures-O', ')-O', 'This-O', 'supports-O', 'ongoing-O', 'concerns-O', 'about-O', 'intensive-O', 'MTX-B-Chemical']
['Tranexamic-B-Chemical', 'acid-I-Chemical', 'overdosage-O', ',-O', 'induced-O', 'generalized-O', 'seizure-B-Disease', 'in-O', 'renal-B-Disease', 'failure-I-Disease', '.-O']
['We-O', 'report-O', 'a-O', '45-O', ',-O', 'year-O', ',-O', 'old-O', 'lady-O', 'with-O', 'chronic-B-Disease', 'kidney-I-Disease', 'disease-I-Disease', 'stage-O', '4-O', 'due-O', 'to-O', 'chronic-B-Disease', 'tubulointerstial-B-Disease', '.-O']
['She-O', 'was-O', 'admitted-O', 'to-O', 'our-O', 'center-O', 'for-O', 'severe-O', 'anemia-B-Disease', 'due-O', 'to-O', 'menorrhagia-B-Disease', 'and-O', 'deterioration-O', 'of-O', 'renal-O', 'function-O', '.-O']
['She-O', 'was-O', 'infused-O', 'three-O', 'units-O', 'of-O', 'packed-O', 'cells-O', 'during-O', 'a-O', 'session-O', 'of-O', 'hemodialysis-O', '.-O']
['Tranexamic-B-Chemical', 'acid-I-Chemical', '(-O', 'TNA-B-Chemical', ')-O', '1-O', 'g-O', '8-O', ',-O', 'hourly-O', 'was-O', 'administered-O', 'to-O', 'her-O', 'to-O', 'control-O', 'bleeding-B-Disease', 'per-O', 'vaginum-O', '.-O']
['Two-O', 'hours-O', 'after-O', 'the-O', 'sixth-O', 'dose-O', 'of-O', 'TNA-B-Chemical', ',-O', 'she-O', 'had-O', 'an-O', 'episode-O', 'of-O', 'generalized-O', 'tonic-O', 'clonic-O', 'convulsions-B-Disease', '.-O']
['TNA-B-Chemical', 'was-O', 'discontinued-O', '.-O']
['Investigations-O', 'of-O', 'the-O', 'patient-O', 'revealed-O', 'no-O', 'biochemical-O', 'or-O', 'structural-O', 'central-O', 'nervous-O', 'system-O', 'abnormalities-O', 'that-O', 'could-O', 'have-O', 'provoked-O', 'the-O', 'convulsions-B-Disease', '.-O']
['She-O', 'did-O', 'not-O', 'require-O', 'any-O', 'further-O', 'dialytic-O', 'support-O', '.-O']
['She-O', 'had-O', 'no-O', 'further-O', 'episodes-O', 'of-O', 'convulsion-B-Disease', 'till-O', 'dis-O', 'charge-O', 'and-O', 'during-O', 'the-O', 'two-O', 'months-O', 'of-O', 'follow-O', '--O', 'up-O', '.-O']
['Thus-O', ',-O', 'the-O', 'precipitating-O', 'cause-O', 'of-O', 'convulsions-B-Disease', 'was-O', 'believed-O', 'to-O', 'be-O', 'an-O', 'overdose-O', 'of-O', 'TNA-B-Chemical']
['Pre-O', ',-O', 'treatment-O', 'of-O', 'bupivacaine-B-Chemical', ',-O', 'induced-O', 'cardiovascular-B-Disease', 'depression-I-Disease', 'using-O', 'different-O', 'lipid-O', 'formulations-O', 'of-O', 'propofol-B-Chemical', '.-O']
['BACKGROUND-O', ':-O', 'Pre-O', ',-O', 'treatment-O', 'with-O', 'lipid-O', 'emulsions-O', 'has-O', 'been-O', 'shown-O', 'to-O', 'increase-O', 'lethal-O', 'doses-O', 'of-O', 'bupivacaine-B-Chemical', ',-O', 'and-O', 'the-O', 'lipid-O', 'content-O', 'of-O', 'propofol-B-Chemical', 'may-O', 'alleviate-O', 'bupivacaine-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', '.-O']
['The-O', 'aim-O', 'of-O', 'this-O', 'study-O', 'is-O', 'to-O', 'investigate-O', 'the-O', 'effects-O', 'of-O', 'propofol-B-Chemical', 'in-O', 'intralipid-O', 'or-O', 'medialipid-O', 'emulsions-O', 'on-O', 'bupivacaine-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', '.-O']
['METHODS-O', ':-O', 'Rats-O', 'were-O', 'anaesthetised-O', 'with-O', 'ketamine-B-Chemical', 'and-O', 'were-O', 'given-O', '0-O', '.-O']
['5-O', 'mg-O', '/-O', 'kg-O', '/-O', 'min-O', 'propofol-B-Chemical', 'in-O', 'intralipid-O', '(-O', 'Group-O', 'P-O', ')-O', 'propofol-B-Chemical', 'in-O', 'medialipid-O', '(-O', 'Group-O', 'L-O', ')-O', 'or-O', 'saline-O', '(-O', 'Group-O', 'C-O', ')-O', 'over-O', '20-O', 'min-O', '.-O']
['Thereafter-O', ',-O', '2-O', 'mg-O', '/-O', 'kg-O', '/-O', 'min-O', 'bupivacaine-B-Chemical', '0-O', '.-O']
['5-O', '%-O', 'was-O', 'infused-O', '.-O']
['We-O', 'recorded-O', 'time-O', 'to-O', 'first-O', 'dysrhythmia-B-Disease', 'occurrence-O', ',-O', 'respective-O', 'times-O', 'to-O', '25-O', '%-O', 'and-O', '50-O', '%-O', 'reduction-O', 'of-O', 'the-O', 'heart-O', 'rate-O', '(-O', 'HR-O', ')-O', 'and-O', 'mean-O', 'arterial-O', 'pressure-O', ',-O', 'and-O', 'time-O', 'to-O', 'asystole-B-Disease', 'and-O', 'total-O', 'amount-O', 'of-O', 'bupivacaine-B-Chemical', 'consumption-O', '.-O']
['Blood-O', 'and-O', 'tissue-O', 'samples-O', 'were-O', 'collected-O', 'following-O', 'asystole-B-Disease', '.-O']
['RESULTS-O', ':-O', 'The-O', 'time-O', 'to-O', 'first-O', 'dysrhythmia-B-Disease', 'occurrence-O', ',-O', 'time-O', 'to-O', '25-O', '%-O', 'and-O', '50-O', '%-O', 'reductions-O', 'in-O', 'HR-O', ',-O', 'and-O', 'time-O', 'to-O', 'asystole-B-Disease', 'were-O', 'longer-O', 'in-O', 'Group-O', 'P-O', 'than-O', 'the-O', 'other-O', 'groups-O', '.-O']
['The-O', 'cumulative-O', 'bupivacaine-B-Chemical', 'dose-O', 'given-O', 'at-O', 'those-O', 'time-O', 'points-O', 'was-O', 'higher-O', 'in-O', 'Group-O', 'P-O', '.-O']
['Plasma-O', 'bupivacaine-B-Chemical', 'levels-O', 'were-O', 'significantly-O', 'lower-O', 'in-O', 'Group-O', 'P-O', 'than-O', 'in-O', 'Group-O', 'C-O', '.-O']
['Bupivacaine-B-Chemical', 'levels-O', 'in-O', 'the-O', 'brain-O', 'and-O', 'heart-O', 'were-O', 'significantly-O', 'lower-O', 'in-O', 'Group-O', 'P-O', 'and-O', 'Group-O', 'L-O', 'than-O', 'in-O', 'Group-O', 'C-O', '.-O']
['CONCLUSION-O', ':-O', 'We-O', 'conclude-O', 'that-O', 'pre-O', ',-O', 'treatment-O', 'with-O', 'propofol-B-Chemical', 'in-O', 'intralipid-O', ',-O', 'compared-O', 'with-O', 'propofol-B-Chemical', 'in-O', 'medialipid-O', 'or-O', 'saline-O', ',-O', 'delayed-O', 'the-O', 'onset-O', 'of-O', 'bupivacaine-B-Chemical', ',-O', 'induced-O', 'cardiotoxic-B-Disease', 'effects-O', 'as-O', 'well-O', 'as-O', 'reduced-O', 'plasma-O', 'bupivacaine-B-Chemical', 'levels-O', '.-O']
['Further-O', 'studies-O', 'are-O', 'needed-O', 'to-O', 'explore-O', 'tissue-O', 'bupivacaine-B-Chemical', 'levels-O', 'of-O', 'propofol-B-Chemical']
['Drug-Induced-B-Disease', 'Acute-B-Disease', 'Liver-B-Disease', 'Injury-I-Disease', 'Within-O', '12-O', 'Hours-O', 'After-O', 'Fluvastatin-B-Chemical', 'Therapy-O', '.-O']
['Although-O', 'statins-B-Chemical', 'are-O', 'generally-O', 'well-O', ',-O', 'tolerated-O', 'drugs-O', ',-O', 'recent-O', 'cases-O', 'of-O', 'drug-induced-O', 'liver-B-Disease', 'injury-I-Disease', 'associated-O', 'with-O', 'their-O', 'use-O', 'have-O', 'been-O', 'reported-O', '.-O']
['A-O', '52-O', ',-O', 'year-O', ',-O', 'old-O', 'Chinese-O', 'man-O', 'reported-O', 'with-O', 'liver-B-Disease', 'damage-I-Disease', ',-O', 'which-O', 'appeared-O', '12-O', 'hours-O', 'after-O', 'beginning-O', 'treatment-O', 'with-O', 'fluvastatin-B-Chemical', '.-O']
['Patient-O', 'presented-O', 'with-O', 'complaints-O', 'of-O', 'increasing-O', 'nausea-B-Disease', ',-O', 'anorexia-B-Disease', ',-O', 'and-O', 'upper-O', 'abdominal-B-Disease', 'pain-I-Disease', '.-O']
['His-O', 'laboratory-O', 'values-O', 'showed-O', 'elevated-O', 'creatine-B-Chemical', 'kinase-O', 'and-O', 'transaminases-O', '.-O']
['Testing-O', 'for-O', 'autoantibodies-O', 'was-O', 'also-O', 'negative-O', '.-O']
['The-O', 'liver-O', 'biochemistries-O', 'eventually-O', 'normalized-O', 'within-O', '3-O', 'weeks-O', 'of-O', 'stopping-O', 'the-O', 'fluvastatin-B-Chemical', '.-O']
['Therefore-O', ',-O', 'when-O', 'prescribing-O', 'statins-B-Chemical', ',-O', 'the-O', 'possibility-O', 'of-O', 'hepatic-B-Disease', 'damage-I-Disease']
['Fluconazole-B-Chemical', 'associated-O', 'agranulocytosis-B-Disease', 'and-O', 'thrombocytopenia-B-Disease', '.-O']
['CASE-O', ':-O', 'We-O', 'describe-O', 'a-O', 'second-O', 'case-O', 'of-O', 'fluconazole-B-Chemical', 'associated-O', 'agranulocytosis-B-Disease', 'with-O', 'thrombocytopenia-B-Disease', 'and-O', 'recovery-O', 'upon-O', 'discontinuation-O', 'of-O', 'therapy-O', '.-O']
['The-O', 'patient-O', 'began-O', 'to-O', 'have-O', 'changes-O', 'in-O', 'white-O', 'blood-O', 'cells-O', 'and-O', 'platelets-O', 'within-O', '48-O', 'h-O', 'of-O', 'administration-O', 'of-O', 'fluconazole-B-Chemical', 'and-O', 'began-O', 'to-O', 'recover-O', 'with-O', '48-O', 'h-O', 'of-O', 'discontinuation-O', '.-O']
['This-O', 'case-O', 'highlights-O', 'that-O', 'drug-O', ',-O', 'induced-O', 'blood-B-Disease', 'dyscrasias-I-Disease', 'can-O', 'occur-O', 'unexpectedly-O', 'as-O', 'a-O', 'result-O', 'of-O', 'treatment-O', 'with-O', 'a-O', 'commonly-O', 'used-O', 'drug-O', 'thought-O', 'to-O', 'be-O', 'x-O', 'safe-O', '.-O', 'CONCLUSION-O', ':-O', 'According-O', 'to-O', 'Naranjo-O', 'x-O', 's-O', 'algorithm-O', 'the-O', 'likelihood-O', 'that-O', 'our-O', 'patient-O', 'x-O', 's-O', 'agranulocytosis-B-Disease', 'and-O', 'thrombocytopenia-B-Disease', 'occurred-O', 'as-O', 'a-O', 'result-O', 'of-O', 'therapy-O', 'with-O', 'fluconazole-B-Chemical', 'is-O', 'probable-O', ',-O', 'with-O', 'a-O', 'total-O', 'of-O', 'six-O', 'points-O', '.-O']
['We-O', 'feel-O', 'that-O', 'the-O', 'weight-O', 'of-O', 'the-O', 'overall-O', 'evidence-O', 'of-O', 'this-O', 'evidence-O', 'is-O', 'strong-O', '.-O']
['In-O', 'particular-O', 'the-O', 'temporal-O', 'relationship-O', 'of-O', 'bone-B-Disease', 'marrow-I-Disease', 'suppression-I-Disease', 'to-O', 'the-O', 'initiation-O', 'of-O', 'fluconazole-B-Chemical']
['Two-O', ',-O', 'dimensional-O', 'speckle-O', 'tracking-O', 'echocardiography-O', 'combined-O', 'with-O', 'high-O', ',-O', 'sensitive-O', 'cardiac-O', 'troponin-O', 'T-O', 'in-O', 'early-O', 'detection-O', 'and-O', 'prediction-O', 'of-O', 'cardiotoxicity-B-Disease', 'during-O', 'epirubicine-B-Chemical', ',-O', 'based-O', 'chemotherapy-O', '.-O']
['AIMS-O', ':-O', 'To-O', 'investigate-O', 'whether-O', 'alterations-O', 'of-O', 'myocardial-O', 'strain-O', 'and-O', 'high-O', ',-O', 'sensitive-O', 'cardiac-O', 'troponin-O', 'T-O', '(-O', 'cTnT-O', ')-O', 'could-O', 'predict-O', 'future-O', 'cardiac-B-Disease', 'dysfunction-I-Disease', 'in-O', 'patients-O', 'after-O', 'epirubicin-B-Chemical', 'exposure-O', '.-O']
['METHODS-O', ':-O', 'Seventy-O', ',-O', 'five-O', 'patients-O', 'with-O', 'non-Hodgkin-B-Disease', 'lymphoma-I-Disease', 'treated-O', 'with-O', 'epirubicin-B-Chemical', 'were-O', 'studied-O', '.-O']
['Blood-O', 'collection-O', 'and-O', 'echocardiography-O', 'were-O', 'performed-O', 'at-O', 'baseline-O', ',-O', '1-O', 'day-O', 'after-O', 'the-O', 'third-O', 'cycle-O', ',-O', 'and-O', '1-O', 'day-O', 'after-O', 'completion-O', 'of-O', 'chemotherapy-O', '.-O']
['Patients-O', 'were-O', 'studied-O', 'using-O', 'echocardiography-O', 'during-O', 'follow-O', ',-O', 'up-O', '.-O']
['Global-O', 'longitudinal-O', '(-O', 'GLS-O', ')-O', 'circumferential-O', '(-O', 'GCS-O', ')-O', 'and-O', 'radial-O', 'strain-O', '(-O', 'GRS-O', ')-O', 'were-O', 'calculated-O', 'using-O', 'speckle-O', 'tracking-O', 'echocardiography-O', '.-O']
['Left-O', 'ventricular-O', 'ejection-O', 'fraction-O', 'was-O', 'analysed-O', 'by-O', 'real-O', 'time-O', '3D-O', 'echocardiography-O', '.-O']
['Cardiotoxicity-B-Disease', 'was-O', 'defined-O', 'as-O', 'a-O', 'reduction-O', 'of-O', 'the-O', 'LVEF-O', 'of-O', '>-O', '5-O', '%-O', 'to-O', '<-O', '55-O', '%-O', 'with-O', 'symptoms-O', 'of-O', 'heart-B-Disease', 'failure-I-Disease', 'or-O', 'an-O', 'asymptomatic-O', 'reduction-O', 'of-O', 'the-O', 'LVEF-O', 'of-O', '>-O', '10-O', '%-O', 'to-O', '<-O', '55-O', '.-O', 'RESULTS-O', ':', 'Fourteen-O', 'patients-O', '(-O', '18-O', '.-O']
['67-O', ')-O', 'developed-O', 'cardiotoxicity-B-Disease', 'after-O', 'treatment-O', '.-O']
['GLS-O', '(-O', '18-O', '.-O']
['48-O', '+-O', '1-O', '.-O']
['72-O', '%-O', 'vs-O', '.--O', '15-O', '.-O']
['96-O', '+-O', '1-O', '.-O']
['6-O', ')-O', 'GCS-O', '(-O', '20-O', '.-O']
['93-O', '+-O', '2-O', '.-O']
['86-O', '%-O', 'vs-O', '.--O', '19-O', '.-O']
['20-O', '+-O', '3-O', '.-O']
['21-O', '),-O', 'and-O', 'GRS-O', '(-O', '39-O', '.-O']
['23-O', '+-O', '6-O', '.-O']
['44-O', '%-O', 'vs-O', '.-O']
['34-O', '.-O']
['98-O', '+-O', '6-O', '.-O']
['2-O', ')-O', 'were-O', 'markedly-O', 'reduced-O', 'and-O', 'cTnT-O', 'was-O', 'elevated-O', 'from-O', '0-O', '.-O']
['0010-O', '+-O', '0-O', '.-O']
['0020-O', 'to-O', '0-O', '.-O']
['0073-O', '+-O', '0-O', '.-O']
['0038-O', 'ng-O', '/-O', 'mL-O', '(-O', 'P-O', 'all-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'at-O', 'the-O', 'completion-O', 'of-O', 'chemotherapy-O', 'compared-O', 'with-O', 'baseline-O', 'values-O', '.-O']
['A-O', '>-O', '15-O', '.-O']
['9-O', '%-O', 'decrease-O', 'in-O', 'GLS-O', '[-O', 'sensitivity-O', ',-O', '86-O', ';-O', 'specificity-O', ',-O', '75-O', ';-O', 'area-O', 'under-O', 'the-O', 'curve-O', '(-O', 'AUC-O', ')-O', '0-O', '.-O']
['815-O', ';-O', 'P-O', '=O', '0-O', '.-O']
['001-O', ']-O', 'and-O', 'a-O', '>-O', '0-O', '.-O']
['004-O', 'ng-O', '/-O', 'mL-O', 'elevation-O', 'in-O', 'cTnT-O', '(-O', 'sensitivity-O', ',-O', '79-O', ';-O', 'specificity-O', ',-O', '64-O', ';-O', 'AUC-O', '=-O', '0-O', '.-O']
['757-O', ';-O', 'P-O', '=O', '0-O', '.-O']
['005-O', ')-O', 'from-O', 'baseline-O', 'to-O', 'the-O', 'third-O', 'cycle-O', 'of-O', 'chemotherapy-O', 'predicted-O', 'later-O', 'cardiotoxicity-B-Disease', '.-O']
['The-O', 'decrease-O', 'in-O', 'GLS-O', 'remained-O', 'the-O', 'only-O', 'independent-O', 'predictor-O', 'of-O', 'cardiotoxicity-B-Disease', '(-O', 'P-O', '=', '0-O', '.-O']
['000-O', ').-O', 'CONCLUSIONS-O', ':-O', 'GLS-O', 'combined-O', 'with-O', 'cTnT-O', 'may-O', 'provide-O', 'a-O', 'reliable-O', 'and-O', 'non-O', ',-O', 'invasive-O', 'method-O', 'to-O', 'predict-O', 'cardiac-B-Disease', 'dysfunction-I-Disease', 'in-O', 'patients-O', 'receiving-O', 'anthracycline-B-Chemical']
['Prevention-O', 'of-O', 'etomidate-B-Chemical', ',-O', 'induced-O', 'myoclonus-B-Disease', ':-O', 'which-O', 'is-O', 'superior-O', ':-O', 'Fentanyl-B-Chemical', ',-O', 'midazolam-B-Chemical', ',-O', 'or-O', 'a-O', 'combination-O', '?-O', 'A-O', 'Retrospective-O', 'comparative-O', 'study-O', '.-O']
['BACKGROUND-O', ':-O', 'In-O', 'this-O', 'retrospective-O', 'comparative-O', 'study-O', ',-O', 'we-O', 'aimed-O', 'to-O', 'compare-O', 'the-O', 'effectiveness-O', 'of-O', 'fentanyl-B-Chemical', ',-O', 'midazolam-B-Chemical', ',-O', 'and-O', 'a-O', 'combination-O', 'of-O', 'fentanyl-B-Chemical', 'and-O', 'midazolam-B-Chemical', 'to-O', 'prevent-O', 'etomidate-B-Chemical', ',-O', 'induced-O', 'myoclonus-B-Disease', '.-O']
['MATERIAL-O', 'AND-O', 'METHODS-O', ':-O', 'This-O', 'study-O', 'was-O', 'performed-O', 'based-O', 'on-O', 'anesthesia-O', 'records-O', '.-O']
['Depending-O', 'on-O', 'the-O', 'drugs-O', 'that-O', 'would-O', 'be-O', 'given-O', 'before-O', 'the-O', 'induction-O', 'of-O', 'anesthesia-O', 'with-O', 'etomidate-B-Chemical', ',-O', 'the-O', 'patients-O', 'were-O', 'separated-O', 'into-O', '4-O', 'groups-O', ':-O', 'no-O', 'pretreatment-O', '(-O', 'Group-O', 'NP-O', '),', 'fentanyl-B-Chemical', '1-O', 'ug-O', '.-O']
['kg-O', ',-O', '1-O', '(-O', 'Group-O', 'F-O', ')-O', 'midazolam-B-Chemical', '0-O', '.-O']
['03-O', 'mg-O', '.-O']
['kg-O', ',-O', '1-O', '(-O', 'Group-O', 'M-O', ')-O', 'and-O', 'midazolam-B-Chemical', '0-O', '.-O']
['015-O', 'mg-O', '.-O']
['kg-O', ',-O', '1-O', '+-O', 'fentanyl-B-Chemical', '0-O', '.-O']
['5-O', 'ug-O', '.-O']
['kg-O', ',-O', '1-O', '(-O', 'Group-O', 'FM-O', ')-O', '.-O', 'Patients-O', 'who-O', 'received-O', 'the-O', 'same-O', 'anesthetic-O', 'procedure-O', 'were-O', 'selected-O', ':-O', '2-O', 'minutes-O', 'after-O', 'intravenous-O', 'injections-O', 'of-O', 'the-O', 'pretreatment-O', 'drugs-O', ',-O', 'anesthesia-O', 'is-O', 'induced-O', 'with-O', '0-O', '.-O']
['3-O', 'mg-O', '.-O']
['kg-O', ',-O', '1-O', 'etomidate-B-Chemical', 'injected-O', 'intravenously-O', 'over-O', 'a-O', 'period-O', 'of-O', '20-O', ',-O', '30-O', 'seconds-O', '.-O']
['Myoclonic-B-Disease', 'movements-O', 'are-O', 'evaluated-O', ',-O', 'which-O', 'were-O', 'observed-O', 'and-O', 'graded-O', 'according-O', 'to-O', 'clinical-O', 'severity-O', 'during-O', 'the-O', '2-O', 'minutes-O', 'after-O', 'etomidate-B-Chemical', 'injection-O', '.-O']
['The-O', 'severity-O', 'of-O', 'pain-B-Disease', 'due-O', 'to-O', 'etomidate-B-Chemical', 'injection-O', ',-O', 'mean-O', 'arterial-O', 'pressure-O', ',-O', 'heart-O', 'rate-O', ',-O', 'and-O', 'adverse-O', 'effects-O', 'were-O', 'also-O', 'evaluated-O', '.-O']
['RESULTS-O', ':-O', 'Study-O', 'results-O', 'showed-O', 'that-O', 'myoclonus-B-Disease', 'incidence-O', 'was-O', '85-O', ',-O', '40-O', ',-O', '70-O', ',-O', 'and-O', '25-O', '%-O', 'in-O', 'Group-O', 'NP-O', ',-O', 'Group-O', 'F-O', ',-O', 'Group-O', 'M-O', ',-O', 'and-O', 'Group-O', 'FM-O', ',-O', 'respectively-O', ',-O', 'and-O', 'were-O', 'significantly-O', 'lower-O', 'in-O', 'Group-O', 'F-O', 'and-O', 'Group-O', 'FM-O', '.-O']
['CONCLUSIONS-O', ':-O', 'We-O', 'conclude-O', 'that-O', 'pretreatment-O', 'with-O', 'fentanyl-B-Chemical', 'or-O', 'combination-O', 'of-O', 'fentanyl-B-Chemical', 'and-O', 'midazolam-B-Chemical', 'was-O', 'effective-O', 'in-O', 'preventing-O', 'etomidate-B-Chemical', ',-O', 'induced-O', 'myoclonus-B-Disease']
['Cholestatic-B-Disease', 'presentation-O', 'of-O', 'yellow-O', 'phosphorus-B-Chemical', 'poisoning-B-Disease', '.-O']
['Yellow-O', 'phosphorus-B-Chemical', ',-O', 'a-O', 'component-O', 'of-O', 'certain-O', 'pesticide-O', 'pastes-O', 'and-O', 'fireworks-O', ',-O', 'is-O', 'well-O', 'known-O', 'to-O', 'cause-O', 'hepatotoxicity-B-Disease', '.-O']
['Poisoning-O', 'with-O', 'yellow-O', 'phosphorus-B-Chemical', 'classically-O', 'manifests-O', 'with-O', 'acute-B-Disease', 'hepatitis-I-Disease', 'leading-O', 'to-O', 'acute-B-Disease', 'liver-I-Disease', 'failure-I-Disease', 'which-O', 'may-O', 'need-O', 'liver-O', 'transplantation-O', '.-O']
['We-O', 'present-O', 'a-O', 'case-O', 'of-O', 'yellow-O', 'phosphorus-B-Chemical', 'poisoning-O', 'in-O', 'which-O', 'a-O', 'patient-O', 'presented-O', 'with-O', 'florid-O', 'clinical-O', 'features-O', 'of-O', 'cholestasis-B-Disease', 'highlighting-O', 'the-O', 'fact-O', 'that-O', 'cholestasis-B-Disease', 'can-O', 'rarely-O', 'be-O', 'a-O', 'presenting-O', 'feature-O', 'of-O', 'yellow-O', 'phosphorus-B-Chemical', 'hepatotoxicity-O']
['Vasovagal-B-Disease', 'syncope-B-Disease', 'and-O', 'severe-O', 'bradycardia-B-Disease', 'following-O', 'intranasal-O', 'dexmedetomidine-B-Chemical', 'for-O', 'pediatric-O', 'procedural-O', 'sedation-O', '.-O']
['We-O', 'report-O', 'syncope-B-Disease', 'and-O', 'bradycardia-B-Disease', 'in-O', 'an-O', '11-O', ',-O', 'year-O', ',-O', 'old-O', 'girl-O', 'following-O', 'administration-O', 'of-O', 'intranasal-O', 'dexmedetomidine-B-Chemical', 'for-O', 'sedation-O', 'for-O', 'a-O', 'voiding-O', 'cystourethrogram-O', '.-O']
['Following-O', 'successful-O', 'completion-O', 'of-O', 'VCUG-O', 'and-O', 'a-O', '60-O', ',', 'min-O', 'recovery-O', 'period-O', ',', 'the-O', 'patient-O', 'x-O', 's-O', 'level-O', 'of-O', 'consciousness-O', 'and-O', 'vital-O', 'signs-O', 'returned-O', 'to-O', 'presedation-O', 'levels-O', '.-O']
['Upon-O', 'leaving-O', 'the-O', 'sedation-O', 'area-O', ',-O', 'the-O', 'patient-O', 'collapsed-O', ',-O', 'with-O', 'no-O', 'apparent-O', 'inciting-O', 'event-O', '.-O']
['The-O', 'patient-O', 'quickly-O', 'regained-O', 'consciousness-O', 'and-O', 'no-O', 'injury-I-Disease', 'occurred-O', '.-O']
['The-O', 'primary-O', 'abnormality-O', 'found-O', 'was-O', 'persistent-O', 'bradycardia-B-Disease', ',-O', 'and-O', 'she-O', 'was-O', 'admitted-O', 'to-O', 'the-O', 'hospital-O', 'for-O', 'telemetric-O', 'observation-O', '.-O']
['The-O', 'bradycardia-B-Disease']
['Paradoxical-O', 'severe-O', 'agitation-B-Disease', 'induced-O', 'by-O', 'add-O', ',-O', 'on-O', 'high-O', ',-O', 'doses-O', 'quetiapine-B-Chemical', 'in-O', 'schizo-affective-B-Disease', 'disorder-I-Disease', '.-O']
['We-O', 'report-O', 'the-O', 'case-O', 'of-O', 'a-O', '35-O', ',-O', 'year-O', ',-O', 'old-O', 'patient-O', 'suffering-O', 'from-O', 'schizo-affective-B-Disease', 'disorder-I-Disease', 'since-O', 'the-O', 'age-O', 'of-O', '19-O', 'years-O', ',-O', 'treated-O', 'by-O', 'a-O', 'combination-O', 'of-O', 'first-O', ',-O', 'generation-O', 'antipsychotics-O', ',-O', 'zuclopenthixol-B-Chemical', '(-O', '100-O', 'mg-O', '/-O', 'day-O', ')-O', 'and-O', 'lithium-B-Chemical', '(-O', '1200-O', 'mg-O', '/-O', 'day-O', ')-O', '(-O', 'serum-O', 'lithium-O', '=-O', '0-O', '.-O']
['85-O', 'mEq-O', '/-O', 'l-O', ').-O', 'This-O', 'patient-O', 'had-O', 'no-O', 'associated-O', 'personality-B-Disease', 'disorder-I-Disease', '(-O', 'particularly-O', 'no-O', 'antisocial-B-Disease', 'disorder-I-Disease', ')-O', 'and-O', 'no-O', 'substance-B-Disease', 'abuse-B-Disease', 'disorder-I-Disease', '.-O']
['Within-O', 'the-O', '48-O', 'h-O', 'following-O', 'the-O', 'gradual-O', 'introduction-O', 'of-O', 'quetiapine-B-Chemical', '(-O', 'up-O', 'to-O', '600-O', 'mg-O', '/-O', 'day-O', ')-O', 'the-O', 'patient-O', 'presented-O', 'severe-O', 'agitation-B-Disease', 'without-O', 'an-O', 'environmental-O', 'explanation-O', ',-O', 'contrasting-O', 'with-O', 'the-O', 'absence-O', 'of-O', 'a-O', 'history-O', 'of-O', 'aggressiveness-O', 'or-O', 'personality-O', 'disorder-O', '.-O']
['The-O', 'diagnoses-O', 'of-O', 'manic-B-Disease', 'shift-O', 'and-O', 'akathisia-B-Disease', 'were-O', 'dismissed-O', '.-O']
['The-O', 'withdrawal-O', 'and-O', 'the-O', 'gradual-O', 'reintroduction-O', 'of-O', 'quetiapine-B-Chemical', '2-O', 'weeks-O', 'later-O', ',-O', 'which-O', 'led-O', 'to-O', 'another-O', 'severe-O', 'agitation-B-Disease', ',-O', 'enabled-O', 'us-O', 'to-O', 'attribute-O', 'the-O', 'agitation-B-Disease', 'specifically-O', 'to-O', 'quetiapine-B-Chemical']
['Antioxidant-O', 'effects-O', 'of-O', 'bovine-O', 'lactoferrin-B-Chemical', 'on-O', 'dexamethasone-B-Chemical', ',-O', 'induced-O', 'hypertension-B-Disease', 'in-O', 'rat-O', '.-O']
['Dexamethasone-B-Chemical', '-(-O', 'Dex-B-Chemical', ')-O', 'induced-O', 'hypertension-B-Disease', 'is-O', 'associated-O', 'with-O', 'enhanced-O', 'oxidative-O', 'stress-O', '.-O']
['Lactoferrin-B-Chemical', '(-O', 'LF-O', ')', 'is-O', 'an-O', 'iron-B-Chemical', ',-O', 'binding-O', 'glycoprotein-O', 'with-O', 'antihypertensive-O', 'properties-O', '.-O']
['In-O', 'this-O', 'study-O', ',-O', 'we-O', 'investigated-O', 'the-O', 'effect-O', 'of-O', 'chronic-O', 'administration-O', 'of-O', 'LF-B-Chemical', 'on-O', 'oxidative-O', 'stress-O', 'and-O', 'hypertension-B-Disease', 'upon-O', 'Dex-B-Chemical', 'administration-O', '.-O']
['Male-O', 'Wistar-O', 'rats-O', 'were-O', 'treated-O', 'by-O', 'Dex-B-Chemical', '(-O', '30-O', 'u-O', 'g-O', '/-O', 'kg-O', '/-O', 'day-O', 'subcutaneously-O', ')-O', 'or-O', 'saline-O', 'for-O', '14-O', 'days-O', '.-O']
['Oral-O', 'bovine-O', 'LF-B-Chemical', '(-O', '30-O', ',-O', '100-O', ',-O', '300-O', 'mg-O', '/-O', 'kg-O', ')-O', 'was-O', 'given-O', 'from-O', 'day-O', '8-O', 'to-O', '14-O', 'in-O', 'a-O', 'reversal-O', 'study-O', '.-O']
['In-O', 'a-O', 'prevention-O', 'study-O', ',-O', 'rats-O', 'received-O', '4-O', 'days-O', 'of-O', 'LF-B-Chemical', 'treatment-O', 'followed-O', 'by-O', 'Dex-B-Chemical', 'and-O', 'continued-O', 'during-O', 'the-O', 'test-O', 'period-O', '.-O']
['Systolic-O', 'blood-O', 'pressure-O', '(-O', 'SBP-O', ')-O', 'was-O', 'measured-O', 'using-O', 'tail-O', ',-O', 'cuff-O', 'method-O', '.-O']
['Thymus-O', 'weight-O', 'was-O', 'used-O', 'as-O', 'a-O', 'marker-O', 'of-O', 'glucocorticoid-O', 'activity-O', '.-O']
['Plasma-O', 'hydrogen-B-Chemical', 'peroxide-B-Chemical', '(-O', 'H2O2-B-Chemical', ')-O', 'concentration-O', 'and-O', 'ferric-B-Chemical', 'reducing-O', 'antioxidant-O', 'power-O', '(-O', 'FRAP-O', ')-O', 'value-O', 'were-O', 'determined-O', '.-O']
['Dexamethasone-B-Chemical', 'significantly-O', 'increased-O', 'SBP-O', 'and-O', 'plasma-O', 'H2O2-B-Chemical', 'level-O', 'and-O', 'decreased-O', 'thymus-O', 'and-O', 'body-O', 'weights-O', '.-O']
['LF-O', 'lowered-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'and-O', 'dose-O', 'dependently-O', 'prevented-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ')-O', 'Dex-B-Chemical', ',-O', 'induced-O', 'hypertension-B-Disease', '.-O']
['LF-O', 'prevented-O', 'body-O', 'weight-O', 'loss-O', 'and-O', 'significantly-O', 'reduced-O', 'the-O', 'elevated-O', 'plasma-O', 'H2O2-B-Chemical', 'and-O', 'increased-O', 'FRAP-O', 'values-O', '.-O']
['Chronic-O', 'administration-O', 'of-O', 'LF-B-Chemical', 'strongly-O', 'reduced-O', 'the-O', 'blood-O', 'pressure-O', 'and-O', 'production-O', 'of-O', 'ROS-B-Chemical', 'and-O', 'improved-O', 'antioxidant-O', 'capacity-O', 'in-O', 'Dex-B-Chemical', ',-O', 'induced-O', 'hypertension-B-Disease']
['The-O', 'association-O', 'between-O', 'tranexamic-B-Chemical', 'acid-I-Chemical', 'and-O', 'convulsive-B-Disease', 'seizures-I-Disease', 'after-O', 'cardiac-B-Disease', 'surgery-O', ':-O', 'a-O', 'multivariate-O', 'analysis-O', 'in-O', '11-O', '529-O', 'patients-O', '.-O']
['Because-O', 'of-O', 'a-O', 'lack-O', 'of-O', 'contemporary-O', 'data-O', 'regarding-O', 'seizures-B-Disease', 'after-O', 'cardiac-O', 'surgery-O', ',-O', 'we-O', 'undertook-O', 'a-O', 'retrospective-O', 'analysis-O', 'of-O', 'prospectively-O', 'collected-O', 'data-O', 'from-O', '11-O', '529-O', 'patients-O', 'in-O', 'whom-O', 'cardiopulmonary-O', 'bypass-O', 'was-O', 'used-O', 'from-O', 'January-O', '2004-O', 'to-O', 'December-O', '2010-O', '.-O']
['A-O', 'convulsive-B-Disease', 'seizure-B-Disease', 'was-O', 'defined-O', 'as-O', 'a-O', 'transient-O', 'episode-O', 'of-O', 'disturbed-O', 'brain-O', 'function-O', 'characterised-O', 'by-O', 'abnormal-O', 'involuntary-O', 'motor-O', 'movements-O', '.-O']
['Multivariate-O', 'regression-O', 'analysis-O', 'was-O', 'performed-O', 'to-O', 'identify-O', 'independent-O', 'predictors-O', 'of-O', 'postoperative-B-Disease', 'seizures-B-Disease', '.-O']
['A-O', 'total-O', 'of-O', '100-O', '(-O', '0-O', '.-O']
['9-O', ')-O', 'patients-O', 'developed-O', 'postoperative-O', 'convulsive-B-Disease', 'seizures-O', '.-O']
['Generalised-O', 'and-O', 'focal-O', 'seizures-B-Disease', 'were-O', 'identified-O', 'in-O', '68-O', 'and-O', '32-O', 'patients-O', ',-O', 'respectively-O', '.-O']
['The-O', 'median-O', '(-O', 'IQR-O', '[', 'range-O', '])', 'time-O', 'after-O', 'surgery-O', 'when-O', 'the-O', 'seizure-B-Disease', 'occurred-O', 'was-O', '7-O', '(-O', '6-O', ',-O', '12-O', '[', '1-O', ',-O', '216-O', '])', 'h-O', 'and-O', '8-O', '(-O', '6-O', ',-O', '11-O', '[', '4-O', ',-O', '18-O', '])', 'h-O', ',-O', 'respectively-O', '.-O']
['Epileptiform-O', 'findings-O', 'on-O', 'electroencephalography-O', 'were-O', 'seen-O', 'in-O', '19-O', 'patients-O', '.-O']
['Independent-O', 'predictors-O', 'of-O', 'postoperative-O', 'seizures-B-Disease', 'included-O', 'age-O', ',-O', 'female-O', 'sex-O', ',-O', 'redo-O', 'cardiac-O', 'surgery-O', ',-O', 'calcification-O', 'of-O', 'ascending-O', 'aorta-O', ',-O', 'congestive-B-Disease', 'heart-I-Disease', 'failure-I-Disease', ',-O', 'deep-O', 'hypothermic-O', 'circulatory-O', 'arrest-O', ',-O', 'duration-O', 'of-O', 'aortic-O', 'cross-O', 'clamp-O', 'and-O', 'tranexamic-B-Chemical', 'acid-I-Chemical', '.-O']
['When-O', 'tested-O', 'in-O', 'a-O', 'multivariate-O', 'regression-O', 'analysis-O', ',-O', 'tranexamic-B-Chemical', 'acid-I-Chemical', 'was-O', 'a-O', 'strong-O', 'independent-O', 'predictor-O', 'of-O', 'seizures-B-Disease', '(-O', 'OR-O', '14-O', '.-O']
['3-O', ',-O', '95-O', '%-O', 'CI-O', '5-O', '.-O']
['5-O', ',-O', '36-O', '.-O']
['7-O', ';-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'Patients-O', 'with-O', 'convulsive-B-Disease', 'seizures-B-Disease', 'had-O', '2-O', '.-O']
['5-O', 'times-O', 'higher-O', 'in-O', ',-O', 'hospital-O', 'mortality-O', 'rates-O', 'and-O', 'twice-O', 'the-O', 'length-O', 'of-O', 'hospital-O', 'stay-O', 'compared-O', 'with-O', 'patients-O', 'without-O', 'convulsive-B-Disease', 'seizures-I-Disease', '.-O']
['Mean-O', '(-O', 'IQR-O', '[', 'range-O', '])', 'length-O', 'of-O', 'stay-O', 'in-O', 'the-O', 'intensive-O', 'care-O', 'unit-O', 'was-O', '115-O', '(-O', '49-O', ',-O', '228-O', '[', '32-O', ',-O', '481-O', '])', 'h-O', 'in-O', 'patients-O', 'with-O', 'convulsive-B-Disease', 'seizures-B-Disease', 'compared-O', 'with-O', '26-O', '(-O', '22-O', ',-O', '69-O', '[', '14-O', ',-O', '1080-O', '])', 'h-O', 'in-O', 'patients-O', 'without-O', 'seizures-B-Disease', '(-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'Convulsive-B-Disease', 'seizures-I-Disease', 'are-O', 'a-O', 'serious-O', 'postoperative-O', 'complication-O', 'after-O', 'cardiac-O', 'surgery-O', '.-O']
['As-O', 'tranexamic-B-Chemical', 'acid-I-Chemical', 'is-O', 'the-O', 'only-O', 'modifiable-O', 'factor-O', ',-O', 'its-O', 'administration-O', ',-O', 'particularly-O', 'in-O', 'doses-O', 'exceeding-O', '80-O', 'mg-O', '.-O']
['kg-O', '(-O', '1-O', ')-O', 'should-O', 'be-O', 'weighed-O', 'against-O', 'the-O', 'risk-O', 'of-O', 'postoperative-O', 'seizures-B-Disease']
['Dysfunctional-O', 'overnight-O', 'memory-B-Disease', 'consolidation-O', 'in-O', 'ecstasy-B-Chemical', 'users-O', '.-O']
['Sleep-O', 'plays-O', 'an-O', 'important-O', 'role-O', 'in-O', 'the-O', 'consolidation-O', 'and-O', 'integration-O', 'of-O', 'memory-O', 'in-O', 'a-O', 'process-O', 'called-O', 'overnight-O', 'memory-O', 'consolidation-O', '.-O']
['Previous-O', 'studies-O', 'indicate-O', 'that-O', 'ecstasy-B-Chemical', 'users-O', 'have-O', 'marked-O', 'and-O', 'persistent-O', 'neurocognitive-O', 'and-O', 'sleep-related-O', 'impairments-O', '.-O']
['We-O', 'extend-O', 'past-O', 'research-O', 'by-O', 'examining-O', 'overnight-O', 'memory-O', 'consolidation-O', 'among-O', 'regular-O', 'ecstasy-B-Chemical', 'users-O', '(-O', 'n-O', '=', '12-O', ')', 'and-O', 'drug-O', 'naive-O', 'healthy-O', 'controls-O', '(-O', 'n-O', '=', '26-O', ').-O', 'Memory-O', 'recall-O', 'of-O', 'word-O', 'pairs-O', 'was-O', 'evaluated-O', 'before-O', 'and-O', 'after-O', 'a-O', 'period-O', 'of-O', 'sleep-O', ',-O', 'with-O', 'and-O', 'without-O', 'interference-O', 'prior-O', 'to-O', 'testing-O', '.-O']
['In-O', 'addition-O', ',-O', 'we-O', 'assessed-O', 'neurocognitive-O', 'performances-O', 'across-O', 'tasks-O', 'of-O', 'learning-O', ',-O', 'memory-O', 'and-O', 'executive-O', 'functioning-O', '.-O']
['Ecstasy-B-Chemical', 'users-O', 'demonstrated-O', 'impaired-O', 'overnight-O', 'memory-O', 'consolidation-O', ',-O', 'a-O', 'finding-O', 'that-O', 'was-O', 'more-O', 'pronounced-O', 'following-O', 'associative-O', 'interference-O', '.-O']
['Additionally-O', ',-O', 'ecstasy-B-Chemical', 'users-O', 'demonstrated-O', 'impairments-O', 'on-O', 'tasks-O', 'recruiting-O', 'frontostriatal-O', 'and-O', 'hippocampal-O', 'neural-O', 'circuitry-O', ',-O', 'in-O', 'the-O', 'domains-O', 'of-O', 'proactive-O', 'interference-O', 'memory-O', ',-O', 'long-O', ',-O', 'term-O', 'memory-O', ',-O', 'encoding-O', ',-O', 'working-O', 'memory-O', 'and-O', 'complex-O', 'planning-O', '.-O']
['We-O', 'suggest-O', 'that-O', 'ecstasy-B-Chemical', ',-O', 'associated-O', 'dysfunction-O', 'in-O', 'fronto-O', ',-O', 'temporal-O', 'circuitry-O', 'may-O', 'underlie-O', 'overnight-O', 'consolidation-O', 'memory-O', 'impairments-O', 'in-O', 'regular-O', 'ecstasy-B-Chemical']
['Normoammonemic-O', 'encephalopathy-B-Disease', ':-O', 'solely-O', 'valproate-B-Chemical', 'induced-O', 'or-O', 'multiple-O', 'mechanisms-O', '?-O', 'A-O', '77-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'presented-O', 'with-O', 'subacute-O', 'onset-O', 'progressive-O', 'confusion-B-Disease', ',-O', 'aggression-B-Disease', ',-O', 'auditory-B-Disease', 'hallucinations-I-Disease', 'and-O', 'delusions-I-Disease', '.-O']
['In-O', 'the-O', 'preceding-O', 'months-O', ',-O', 'the-O', 'patient-O', 'had-O', 'a-O', 'number-O', 'of-O', 'admissions-O', 'with-O', 'transient-O', 'unilateral-O', 'hemiparesis-B-Disease', 'with-O', 'facial-O', 'droop-O', ',-O', 'and-O', 'had-O', 'been-O', 'started-O', 'on-O', 'valproate-B-Chemical', 'for-O', 'presumed-O', 'hemiplegic-O', 'migraine-B-Disease', '.-O']
['Valproate-B-Chemical', 'was-O', 'withdrawn-O', 'soon-O', 'after-O', 'admission-O', 'and-O', 'her-O', 'cognitive-O', 'abilities-O', 'have-O', 'gradually-O', 'improved-O', 'over-O', '3-O', 'months-O', 'of-O', 'follow-O', ',-O', 'up-O', '.-O']
['Valproate-B-Chemical', 'levels-O', 'taken-O', 'prior-O', 'to-O', 'withdrawal-O', 'were-O', 'subtherapeutic-O', 'and-O', 'the-O', 'patient-O', 'was-O', 'normoammonaemic-O', '.-O']
['EEG-O', 'undertaken-O', 'during-O', 'inpatient-O', 'stay-O', 'showed-O', 'changes-O', 'consistent-O', 'with-O', 'encephalopathy-B-Disease', ',-O', 'and-O', 'low-O', 'titre-O', 'N-methyl-D-aspartate-B-Chemical', '(-O', 'NMDA-B-Chemical', ')-O', 'receptor-O', 'antibodies-O', 'were-O', 'present-O', 'in-O', 'this-O', 'patient-O', '.-O']
['The-O', 'possible-O', 'aetiologies-O', 'of-O', 'valproate-B-Chemical', ',-O', 'induced-O', 'encephalopathy-B-Disease', 'and-O', 'NMDA-B-Chemical', 'receptor-O', ',-O', 'associated-O', 'encephalitis-B-Disease']
['Cerebellar-B-Disease', 'and-O', 'oculomotor-B-Disease', 'dysfunction-I-Disease', 'induced-O', 'by-O', 'rapid-O', 'infusion-O', 'of-O', 'pethidine-B-Chemical', '.-O']
['Pethidine-B-Chemical', 'is-O', 'an-O', 'opioid-O', 'that-O', 'gains-O', 'its-O', 'popularity-O', 'for-O', 'the-O', 'effective-O', 'pain-B-Disease', 'control-O', 'through-O', 'acting-O', 'on-O', 'the-O', 'opioid-O', ',-O', 'receptors-O', '.-O']
['However-O', ',-O', 'rapid-O', 'pain-B-Disease', 'relief-O', 'sometimes-O', 'brings-O', 'about-O', 'unfavourable-O', 'side-O', 'effects-O', 'that-O', 'largely-O', 'limit-O', 'its-O', 'clinical-O', 'utility-O', '.-O']
['Common-O', 'side-O', 'effects-O', 'include-O', 'nausea-B-Disease', ',-O', 'vomiting-B-Disease', 'and-O', 'hypotension-B-Disease', '.-O']
['In-O', 'patients-O', 'with-O', 'impaired-B-Disease', 'renal-O', 'and-O', 'liver-O', 'function-O', ',-O', 'and-O', 'those-O', 'who-O', 'need-O', 'long-O', ',-O', 'term-O', 'pain-B-Disease', 'control-O', ',-O', 'pethidine-B-Chemical', 'may-O', 'cause-O', 'excitatory-O', 'central-O', 'nervous-O', 'system-O', '(-O', 'CNS-O', ')-O', 'effects-O', 'through-O', 'its-O', 'neurotoxic-O', 'metabolite-O', ',-O', 'norpethidine-B-Chemical', ',-O', 'resulting-O', 'in-O', 'irritability-B-Disease', 'and-O', 'seizure-B-Disease', 'attack-O', '.-O']
['On-O', 'the-O', 'contrary-O', ',-O', 'though-O', 'not-O', 'clinically-O', 'apparent-O', ',-O', 'pethidine-B-Chemical', 'potentially-O', 'causes-O', 'inhibitory-O', 'impacts-O', 'on-O', 'the-O', 'CNS-O', 'and-O', 'impairs-O', 'normal-O', 'cerebellar-O', 'and-O', 'oculomotor-O', 'function-O', 'in-O', 'the-O', 'short-O', 'term-O', '.-O']
['In-O', 'this-O', 'case-O', 'report-O', ',-O', 'we-O', 'highlight-O', 'opioid-O', 'x-O', 's-O', 'inhibitory-O', 'side-O', 'effects-O', 'on-O', 'the-O', 'cerebellar-O', 'structure-O', 'that-O', 'causes-O', 'dysmetria-B-Disease', ',-O', 'dysarthria-B-Disease']
['Baboon-O', 'syndrome-B-Disease', 'induced-O', 'by-O', 'ketoconazole-B-Chemical', '.-O']
['A-O', '27-O', ',-O', 'year-O', ',-O', 'old-O', 'male-O', 'patient-O', 'presented-O', 'with-O', 'a-O', 'maculopapular-B-Disease', 'eruption-O', 'on-O', 'the-O', 'flexural-O', 'areas-O', 'and-O', 'buttocks-O', 'after-O', 'using-O', 'oral-O', 'ketoconazole-B-Chemical', '.-O']
['The-O', 'patient-O', 'was-O', 'diagnosed-O', 'with-O', 'drug-O', ',-O', 'induced-O', 'baboon-O', 'syndrome-B-Disease', 'based-O', 'on-O', 'his-O', 'history-O', ',-O', 'which-O', 'included-O', 'prior-O', 'sensitivity-O', 'to-O', 'topical-O', 'ketoconazole-B-Chemical', ',-O', 'a-O', 'physical-O', 'examination-O', ',-O', 'and-O', 'histopathological-O', 'findings-O', '.-O']
['Baboon-O', 'syndrome-B-Disease', 'is-O', 'a-O', 'drug-O', ',-O', 'or-O', 'contact-O', 'allergen-O', ',-O', 'related-O', 'maculopapular-O', 'eruption-O', 'that-O', 'typically-O', 'involves-O', 'the-O', 'flexural-O', 'and-O', 'gluteal-O', 'areas-O', '.-O']
['To-O', 'the-O', 'best-O', 'of-O', 'our-O', 'knowledge-O', ',-O', 'this-O', 'is-O', 'the-O', 'first-O', 'reported-O', 'case-O', 'of-O', 'ketoconazole-B-Chemical', ',-O', 'induced-O', 'baboon-O', 'syndrome-B-Disease']
['A-O', 'Case-O', 'of-O', 'Sudden-O', 'Cardiac-B-Disease', 'Death-B-Disease', 'due-O', 'to-O', 'Pilsicainide-B-Chemical', ',-O', 'Induced-O', 'Torsades-B-Disease', 'de-O', 'Pointes-I-Disease', '.-O']
['An-O', '84-O', ',-O', 'year-O', ',-O', 'old-O', 'male-O', 'received-O', 'oral-O', 'pilsicainide-B-Chemical', ',-O', 'a-O', 'pure-O', 'sodium-B-Chemical', 'channel-O', 'blocker-O', 'with-O', 'slow-O', 'recovery-O', 'kinetics-O', ',-O', 'to-O', 'convert-O', 'his-O', 'paroxysmal-O', 'atrial-B-Disease', 'fibrillation-I-Disease', 'to-O', 'a-O', 'sinus-B-Disease', 'rhythm-O', ';-O', 'the-O', 'patient-O', 'developed-O', 'sudden-O', 'cardiac-B-Disease', 'death-I-Disease', 'two-O', 'days-O', 'later-O', '.-O']
['The-O', 'Holter-O', 'electrocardiogram-O', ',-O', 'which-O', 'was-O', 'worn-O', 'by-O', 'chance-O', ',-O', 'revealed-O', 'torsade-B-Disease', 'de-O', 'pointes-I-Disease', 'with-O', 'gradually-O', 'prolonged-O', 'QT-O', 'intervals-O', '.-O']
['This-O', 'drug-O', 'is-O', 'rapidly-O', 'absorbed-O', 'from-O', 'the-O', 'gastrointestinal-O', 'tract-O', ',-O', 'and-O', 'most-O', 'of-O', 'it-O', 'is-O', 'excreted-O', 'from-O', 'the-O', 'kidney-O', '.-O']
['Although-O', 'the-O', 'patient-O', 'x-O', 's-O', 'renal-O', 'function-O', 'was-O', 'not-O', 'highly-O', 'impaired-O', 'and-O', 'the-O', 'dose-O', 'of-O', 'pilsicainide-B-Chemical', 'was-O', 'low-O', ',-O', 'the-O', 'plasma-O', 'concentration-O', 'of-O', 'pilsicainide-B-Chemical', 'may-O', 'have-O', 'been-O', 'high-O', ',-O', 'which-O', 'can-O', 'produce-O', 'torsades-B-Disease', 'de-I-Disease', 'pointes-I-Disease', 'in-O', 'the-O', 'octogenarian-O', '.-O']
['Although-O', 'the-O', 'oral-O', 'administration-O', 'of-O', 'class-O', 'IC-O', 'drugs-O', ',-O', 'including-O', 'pilsicainide-B-Chemical', ',-O', 'is-O', 'effective-O', 'to-O', 'terminate-O', 'atrial-B-Disease', 'fibrillation-I-Disease']
['All-trans-B-Chemical', 'retinoic-B-Chemical', 'acid-I-Chemical', ',-O', 'induced-O', 'inflammatory-O', 'myositis-B-Disease', 'in-O', 'a-O', 'patient-O', 'with-O', 'acute-B-Disease', 'promyelocytic-I-Disease', 'leukemia-I-Disease', '.-O']
['All-trans-O', 'retinoic-O', 'acid-O', '(-O', 'ATRA-O', '),', 'a-O', 'component-O', 'of-O', 'standard-O', 'therapy-O', 'for-O', 'acute-O', 'promyelocytic-O', 'leukemia-O', '(-O', 'APL-O', '),', 'is-O', 'associated-O', 'with-O', 'potentially-O', 'serious-O', 'but-O', 'treatable-O', 'adverse-O', 'effects-O', 'involving-O', 'numerous-O', 'organ-O', 'systems-O', ',-O', 'including-O', 'rare-O', 'skeletal-O', 'muscle-O', 'involvement-O', '.-O']
['Only-O', 'a-O', 'handful-O', 'of-O', 'cases-O', 'of-O', 'ATRA-B-Chemical', ',-O', 'induced-O', 'myositis-B-Disease', 'in-O', 'children-O', 'have-O', 'been-O', 'reported-O', ',-O', 'and-O', 'none-O', 'in-O', 'the-O', 'radiology-O', 'literature-O', '.-O']
['We-O', 'present-O', 'such-O', 'a-O', 'case-O', 'in-O', 'a-O', '15-O', ',-O', 'year-O', ',-O', 'old-O', 'boy-O', 'with-O', 'APL-B-Disease', '.-O']
['Tolerability-O', 'of-O', 'lomustine-B-Chemical', 'in-O', 'combination-O', 'with-O', 'cyclophosphamide-B-Chemical', 'in-O', 'dogs-O', 'with-O', 'lymphoma-B-Disease', '.-O']
['This-O', 'retrospective-O', 'study-O', 'describes-O', 'toxicity-O', 'associated-O', 'with-O', 'a-O', 'protocol-O', 'of-O', 'lomustine-B-Chemical', '(-O', 'CCNU-B-Chemical', ')-O', 'and-O', 'cyclophosphamide-B-Chemical', '(-O', 'CTX-B-Chemical', ')-O', 'in-O', 'dogs-O', 'with-O', 'lymphoma-B-Disease', '.-O']
['CCNU-B-Chemical', 'was-O', 'administered-O', 'per-O', 'os-O', '(-O', 'PO-O', ')-O', 'at-O', 'a-O', 'targeted-O', 'dosage-O', 'of-O', '60-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'body-O', 'surface-O', 'area-O', 'on-O', 'day-O', '0-O', ',-O', 'CTX-B-Chemical', 'was-O', 'administered-O', 'PO-O', 'at-O', 'a-O', 'targeted-O', 'dosage-O', 'of-O', '250-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'divided-O', 'over-O', 'days-O', '0-O', 'through-O', '4-O', ',-O', 'and-O', 'all-O', 'dogs-O', 'received-O', 'prophylactic-O', 'antibiotics-O', '.-O']
['Ninety-O', 'treatments-O', 'were-O', 'given-O', 'to-O', 'the-O', '57-O', 'dogs-O', 'included-O', 'in-O', 'the-O', 'study-O', '.-O']
['Neutropenia-B-Disease', 'was-O', 'the-O', 'principal-O', 'toxic-O', 'effect-O', ',-O', 'and-O', 'the-O', 'overall-O', 'frequency-O', 'of-O', 'grade-O', '4-O', 'neutropenia-B-Disease', 'after-O', 'the-O', 'first-O', 'treatment-O', 'of-O', 'CCNU-B-Chemical', '/', 'CTX-B-Chemical', 'was-O', '30-O', '(-O', '95-O', '%-O', 'confidence-O', 'interval-O', ',-O', '19-O', ',', '43-O', ')-O', '.-O', 'The-O', 'mean-O', 'body-O', 'weight-O', 'of-O', 'dogs-O', 'with-O', 'grade-O', '4-O', 'neutropenia-B-Disease', '(-O', '19-O', '.-O']
['7-O', 'kg-O', '+-O', '13-O', '.-O']
['4-O', 'kg-O', ')-O', 'was-O', 'significantly-O', 'less-O', 'than-O', 'the-O', 'mean-O', 'body-O', 'weight-O', 'of-O', 'dogs-O', 'that-O', 'did-O', 'not-O', 'develop-O', 'grade-O', '4-O', 'neutropenia-B-Disease', '(-O', '31-O', '.-O']
['7-O', 'kg-O', '+-O', '12-O', '.-O']
['4-O', 'kg-O', ';-O', 'P-O', '=.-O', '005-O', ')-O', '.-O', 'One-O', 'dog-O', '(-O', '3-O', ')-O', 'developed-O', 'hematologic-O', 'changes-O', 'suggestive-O', 'of-O', 'hepatotoxicity-B-Disease', '.-O']
['No-O', 'dogs-O', 'had-O', 'evidence-O', 'of-O', 'either-O', 'renal-B-Disease', 'toxicity-O', 'or-O', 'hemorrhagic-B-Disease', 'cystitis-I-Disease', '.-O']
['Adverse-O', 'gastrointestinal-B-Disease', 'effects-O', 'were-O', 'uncommon-O', '.-O']
['On-O', 'the-O', 'basis-O', 'of-O', 'the-O', 'findings-O', 'reported-O', 'herein-O', ',-O', 'a-O', 'dose-O', 'of-O', '60-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')', 'of-O', 'CCNU-B-Chemical', 'combined-O', 'with-O', '250-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')', 'of-O', 'CTX-B-Chemical', '(-O', 'divided-O', 'over-O', '5-O', 'days-O', ')', 'q-O', '4-O', 'wk-O', 'is-O', 'tolerable-O', 'in-O', 'tumor-O']
['Nelarabine-B-Chemical', 'neurotoxicity-B-Disease', 'with-O', 'concurrent-O', 'intrathecal-O', 'chemotherapy-O', ':-O', 'Case-O', 'report-O', 'and-O', 'review-O', 'of-O', 'literature-O', '.-O']
['Severe-O', 'nelarabine-B-Chemical', 'neurotoxicity-B-Disease', 'in-O', 'a-O', 'patient-O', 'who-O', 'received-O', 'concurrent-O', 'intrathecal-O', '(-O', 'IT-O', ')', 'chemotherapy-O', 'is-O', 'reported-O', '.-O']
['A-O', '37-O', ',-O', 'year-O', ',-O', 'old-O', 'Caucasian-O', 'woman-O', 'with-O', 'a-O', 'history-O', 'of-O', 'T-cell-B-Disease', 'lymphoblastic-I-Disease', 'lymphoma-I-Disease', 'was-O', 'admitted-O', 'for-O', 'relapsed-O', 'disease-O', '.-O']
['She-O', 'was-O', 'originally-O', 'treated-O', 'with-O', 'induction-O', 'chemotherapy-O', 'followed-O', 'by-O', 'an-O', 'autologous-O', 'transplant-O', '.-O']
['She-O', 'developed-O', 'relapsed-O', 'disease-B-Disease', '10-O', 'months-O', 'later-O', 'with-O', 'leukemic-B-Disease', 'involvement-O', '.-O']
['She-O', 'was-O', 're-O', ',-O', 'induced-O', 'with-O', 'nelarabine-B-Chemical', '1500-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'on-O', 'days-O', '1-O', ',-O', '3-O', ',-O', 'and-O', '5-O', 'with-O', '1-O', 'dose-O', 'of-O', 'IT-O', 'cytarabine-B-Chemical', '100-O', 'mg-O', 'on-O', 'day-O', '2-O', 'as-O', 'central-O', 'nervous-O', 'system-O', '(-O', 'CNS-O', ')-O', 'prophylaxis-O', '.-O']
['At-O', 'the-O', 'time-O', 'of-O', 'treatment-O', ',-O', 'she-O', 'was-O', 'on-O', 'continuous-O', 'renal-O', 'replacement-O', 'therapy-O', 'due-O', 'to-O', 'sequelae-O', 'of-O', 'tumor-B-Disease', 'lysis-O', 'syndrome-O', '(-O', 'TLS-O', ').-O', 'She-O', 'tolerated-O', 'therapy-O', 'well-O', ',-O', 'entered-O', 'a-O', 'complete-O', 'remission-O', ',-O', 'and-O', 'recovered-O', 'her-O', 'renal-O', 'function-O', '.-O']
['She-O', 'received-O', 'a-O', 'second-O', 'cycle-O', 'of-O', 'nelarabine-B-Chemical', 'without-O', 'additional-O', 'IT-O', 'prophylaxis-O', 'one-O', 'month-O', 'later-O', '.-O']
['A-O', 'week-O', 'after-O', 'this-O', 'second-O', 'cycle-O', ',-O', 'she-O', 'noted-O', 'numbness-B-Disease', 'in-O', 'her-O', 'lower-O', 'extremities-O', '.-O']
['Predominantly-O', 'sensory-O', ',-O', 'though-O', 'also-O', 'motor-O', 'and-O', 'autonomic-O', ',-O', 'peripheral-B-Disease', 'neuropathy-I-Disease', 'started-O', 'in-O', 'her-O', 'feet-O', ',-O', 'ascended-O', 'proximally-O', 'to-O', 'the-O', 'mid-O', ',-O', 'thoracic-O', 'region-O', ',-O', 'and-O', 'eventually-O', 'included-O', 'her-O', 'distal-O', 'upper-O', 'extremities-O', '.-O']
['A-O', 'magnetic-O', 'resonance-O', 'imaging-O', '(-O', 'MRI-O', ')-O', 'of-O', 'her-O', 'spine-O', 'demonstrated-O', 'changes-O', 'from-O', 'C2-O', 'to-O', 'C6-O', 'consistent-O', 'with-O', 'subacute-O', 'combined-O', 'degeneration-I-Disease', '.-O']
['Nelarabine-B-Chemical', 'was-O', 'felt-O', 'to-O', 'be-O', 'the-O', 'cause-O', 'of-O', 'her-O', 'symptoms-O', '.-O']
['Her-O', 'neuropathy-B-Disease', 'stabilized-O', 'and-O', 'showed-O', 'slight-O', 'improvement-O', 'and-O', 'ultimately-O', 'received-O', 'an-O', 'unrelated-O', ',-O', 'reduced-O', ',-O', 'intensity-O', 'allogeneic-O', 'transplant-O', 'while-O', 'in-O', 'complete-O', 'remission-O', ',-O', 'but-O', 'relapsed-O', 'disease-B-Disease', '10-O', 'weeks-O', 'later-O', '.-O']
['She-O', 'is-O', 'currently-O', 'being-O', 'treated-O', 'with-O', 'best-O', 'supportive-O', 'care-O', '.-O']
['To-O', 'our-O', 'knowledge-O', ',-O', 'this-O', 'is-O', 'the-O', 'first-O', 'published-O', 'case-O', 'report-O', 'of-O', 'severe-O', 'neurotoxicity-B-Disease', 'caused-O', 'by-O', 'nelarabine-B-Chemical']
['Valproate-B-Chemical', ',-O', 'induced-O', 'hyperammonemic-B-Disease', 'encephalopathy-B-Disease', 'in-O', 'a-O', 'renal-O', 'transplanted-O', 'patient-O', '.-O']
['Neurological-B-Disease', 'complications-I-Disease', 'after-O', 'renal-O', 'transplantation-O', 'constitute-O', 'an-O', 'important-O', 'cause-O', 'of-O', 'morbidity-O', 'and-O', 'mortality-O', '.-O']
['Their-O', 'differential-O', 'diagnosis-O', 'is-O', 'difficult-O', 'and-O', 'essential-O', 'for-O', 'subsequent-O', 'patient-O', 'x-O', 's-O', 'management-O', '.-O']
['Valproate-B-Chemical', ',-O', 'induced-O', 'hyperammonemic-B-Disease', 'encephalopathy-B-Disease', 'is-O', 'an-O', 'uncommon-O', 'but-O', 'serious-O', 'effect-O', 'of-O', 'valproate-B-Chemical', 'treatment-O', '.-O']
['Here-O', ',-O', 'we-O', 'describe-O', 'the-O', 'case-O', 'of-O', 'a-O', '15-O', ',-O', 'year-O', ',-O', 'old-O', 'girl-O', 'who-O', 'was-O', 'on-O', 'a-O', 'long-O', ',-O', 'term-O', 'therapy-O', 'with-O', 'valproate-B-Chemical', 'due-O', 'to-O', 'epilepsy-B-Disease', 'and-O', 'revealed-O', 'impaired-O', 'consciousness-B-Disease', 'with-O', 'hyperammonemia-B-Disease', '12-O', 'days-O', 'after-O', 'renal-O', 'transplantation-O', '.-O']
['After-O', 'withdraw-O', 'of-O', 'valproate-B-Chemical', ',-O', 'patients-O', 'x-O', 'symptoms-O', 'resolved-O', 'within-O', '24-O', 'h-O', '.-O']
['Clinicians-O', 'should-O', 'increase-O', 'their-O', 'awareness-O', 'for-O', 'potential-O', 'complication-O', 'of-O', 'valproate-B-Chemical']
['Necrotising-B-Disease', 'fasciitis-I-Disease', 'after-O', 'bortezomib-B-Chemical', 'and-O', 'dexamethasone-B-Chemical', ',-O', 'containing-O', 'regimen-O', 'in-O', 'an-O', 'elderly-O', 'patient-O', 'of-O', 'Waldenstrom-B-Disease', 'macroglobulinaemia-I-Disease', '.-O']
['Bortezomib-B-Chemical', 'and-O', 'high-O', ',-O', 'dose-O', 'dexamethasone-B-Chemical', ',-O', 'containing-O', 'regimens-O', 'are-O', 'considered-O', 'to-O', 'be-O', 'generally-O', 'tolerable-O', 'with-O', 'few-O', 'severe-O', 'bacterial-O', 'infections-O', 'in-O', 'patients-O', 'with-O', 'B-O', 'cell-O', 'malignancies-O', '.-O']
['However-O', ',-O', 'information-O', 'is-O', 'limited-O', 'concerning-O', 'the-O', 'safety-O', 'of-O', 'the-O', 'regimen-O', 'in-O', 'elderly-O', 'patients-O', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'a-O', '76-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'with-O', 'Waldenstrom-B-Disease', 'macroglobulinaemia-I-Disease', 'who-O', 'suffered-O', 'necrotising-B-Disease', 'fasciitis-I-Disease', 'without-O', 'neutropenia-B-Disease', 'after-O', 'the-O', 'combination-O', 'treatment-O', 'with-O', 'bortezomib-B-Chemical', ',-O', 'high-O', ',-O', 'dose-O', 'dexamethasone-B-Chemical', 'and-O', 'rituximab-B-Chemical', '.-O']
['Despite-O', 'immediate-O', 'intravenous-O', 'antimicrobial-O', 'therapy-O', ',-O', 'he-O', 'succumbed-O', '23-O', 'h-O', 'after-O', 'the-O', 'onset-O', '.-O']
['Physicians-O', 'should-O', 'recognise-O', 'the-O', 'possibility-O', 'of-O', 'fatal-O', 'bacterial-O', 'infections-B-Disease', 'related-O', 'to-O', 'bortezomib-B-Chemical', 'plus-O', 'high-O', ',-O', 'dose-O', 'dexamethasone-B-Chemical']
['An-O', 'integrated-O', 'characterization-O', 'of-O', 'serological-O', ',-O', 'pathological-O', ',-O', 'and-O', 'functional-O', 'events-O', 'in-O', 'doxorubicin-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', '.-O']
['Many-O', 'efficacious-O', 'cancer-B-Disease', 'treatments-O', 'cause-O', 'significant-O', 'cardiac-O', 'morbidity-O', ',-O', 'yet-O', 'biomarkers-O', 'or-O', 'functional-O', 'indices-O', 'of-O', 'early-O', 'damage-O', ',-O', 'which-O', 'would-O', 'allow-O', 'monitoring-O', 'and-O', 'intervention-O', ',-O', 'are-O', 'lacking-O', '.-O']
['In-O', 'this-O', 'study-O', ',-O', 'we-O', 'have-O', 'utilized-O', 'a-O', 'rat-O', 'model-O', 'of-O', 'progressive-O', 'doxorubicin-B-Chemical', '(-O', 'DOX-B-Chemical', ')-O', 'induced-O', 'cardiomyopathy-B-Disease', ',-O', 'applying-O', 'multiple-O', 'approaches-O', ',-O', 'including-O', 'cardiac-O', 'magnetic-O', 'resonance-O', 'imaging-O', '(-O', 'MRI-O', '),O', 'to-O', 'provide-O', 'the-O', 'most-O', 'comprehensive-O', 'characterization-O', 'to-O', 'date-O', 'of-O', 'the-O', 'timecourse-O', 'of-O', 'serological-O', ',-O', 'pathological-O', ',-O', 'and-O', 'functional-O', 'events-O', 'underlying-O', 'this-O', 'toxicity-O', '.-O']
['Hannover-O', 'Wistar-O', 'rats-O', 'were-O', 'dosed-O', 'with-O', '1-O', '.-O']
['25-O', 'mg-O', '/-O', 'kg-O', 'DOX-B-Chemical', 'weekly-O', 'for-O', '8-O', 'weeks-O', 'followed-O', 'by-O', 'a-O', '4-O', 'week-O', 'off-O', ',-O', 'dosing-O', 'x-O', 'recovery-O', 'x-O', 'period-O', '.-O']
['Electron-O', 'microscopy-O', 'of-O', 'the-O', 'myocardium-O', 'revealed-O', 'subcellular-O', 'degeneration-O', 'and-O', 'marked-O', 'mitochondrial-O', 'changes-O', 'after-O', 'a-O', 'single-O', 'dose-O', '.-O']
['Histopathological-O', 'analysis-O', 'revealed-O', 'progressive-O', 'cardiomyocyte-O', 'degeneration-B-Disease', ',-O', 'hypertrophy-I-Disease', '/-O', 'cytomegaly-I-Disease', ',-O', 'and-O', 'extensive-O', 'vacuolation-O', 'after-O', 'two-O', 'doses-O', '.-O']
['Extensive-O', 'replacement-O', 'fibrosis-B-Disease', '(-O', 'quantified-O', 'by-O', 'Sirius-O', 'red-O', 'staining-O', ')', 'developed-O', 'during-O', 'the-O', 'off-O', ',-O', 'dosing-O', 'period-O', '.-O']
['Functional-O', 'indices-O', 'assessed-O', 'by-O', 'cardiac-O', 'MRI-O', '(-O', 'including-O', 'left-O', 'ventricular-O', 'ejection-O', 'fraction-O', '(-O', 'LVEF-O', ')-O', 'cardiac-O', 'output-O', ',-O', 'and-O', 'E-O', '/-O', 'A-O', 'ratio-O', ')-O', 'declined-O', 'progressively-O', ',-O', 'reaching-O', 'statistical-O', 'significance-O', 'after-O', 'two-O', 'doses-O', 'and-O', 'culminating-O', 'in-O', 'x-O', 'clinical-O', 'x-O', 'LV-O', 'dysfunction-O', 'by-O', '12-O', 'weeks-O', '.-O']
['Significant-O', 'increases-O', 'in-O', 'peak-O', 'myocardial-B-Disease', 'contrast-O', 'enhancement-O', 'and-O', 'serological-O', 'cardiac-O', 'troponin-O', 'I-O', '(-O', 'cTnI-O', ')-O', 'emerged-O', 'after-O', 'eight-O', 'doses-O', ',-O', 'importantly-O', 'preceding-O', 'the-O', 'LVEF-O', 'decline-O', 'to-O', '<-O', '50-O', '.-O', 'Troponin-O', 'I-O', 'levels-O', 'positively-O', 'correlated-O', 'with-O', 'delayed-O', 'and-O', 'peak-O', 'gadolinium-B-Chemical', 'contrast-O', 'enhancement-O', ',-O', 'histopathological-O', 'grading-O', ',-O', 'and-O', 'diastolic-O', 'dysfunction-O', '.-O']
['In-O', 'summary-O', ',-O', 'subcellular-O', 'cardiomyocyte-O', 'degeneration-O', 'was-O', 'the-O', 'earliest-O', 'marker-O', ',-O', 'followed-O', 'by-O', 'progressive-O', 'functional-O', 'decline-O', 'and-O', 'histopathological-O', 'manifestations-O', '.-O']
['Myocardial-B-Disease', 'contrast-O', 'enhancement-O', 'and-O', 'elevations-O', 'in-O', 'cTnI-O', 'occurred-O', 'later-O', '.-O']
['However-O', ',-O', 'all-O', 'indices-O', 'predated-O', 'x-O', 'clinical-O', 'x-O', 'LV-B-Disease', 'dysfunction-I-Disease']
['Intradermal-O', 'glutamate-B-Chemical', 'and-O', 'capsaicin-B-Chemical', 'injections-O', ':-O', 'intra-O', ',-O', 'and-O', 'interindividual-O', 'variability-O', 'of-O', 'provoked-O', 'hyperalgesia-B-Disease', 'and-O', 'allodynia-B-Disease', '.-O']
['Intradermal-O', 'injections-O', 'of-O', 'glutamate-B-Chemical', 'and-O', 'capsaicin-B-Chemical', 'are-O', 'attractive-O', 'to-O', 'use-O', 'in-O', 'human-O', 'experimental-O', 'pain-B-Disease', 'models-O', 'because-O', 'hyperalgesia-B-Disease', 'and-O', 'allodynia-B-Disease', 'mimic-O', 'isolated-O', 'aspects-O', 'of-O', 'clinical-O', 'pain-B-Disease', 'disorders-O', '.-O']
['The-O', 'aim-O', 'of-O', 'the-O', 'present-O', 'study-O', 'was-O', 'to-O', 'investigate-O', 'the-O', 'reproducibility-O', 'of-O', 'these-O', 'models-O', '.-O']
['Twenty-O', 'healthy-O', 'male-O', 'volunteers-O', '(-O', 'mean-O', 'age-O', '24-O', 'years-O', ';-O', 'range-O', '18-O', ',-O', '38-O', 'years-O', ')-O', 'received-O', 'intradermal-O', 'injections-O', 'of-O', 'glutamate-B-Chemical', 'and-O', 'capsaicin-B-Chemical', 'in-O', 'the-O', 'volar-O', 'forearm-O', '.-O']
['Magnitudes-O', 'of-O', 'secondary-B-Disease', 'pinprick-O', 'hyperalgesia-B-Disease', 'and-O', 'brush-O', ',-O', 'evoked-O', 'allodynia-B-Disease', 'were-O', 'investigated-O', 'using-O', 'von-O', 'Frey-O', 'filaments-O', '(-O', 'gauges-O', '10-O', ',-O', '15-O', ',-O', '60-O', 'and-O', '100-O', 'g-O', ')-O', 'and-O', 'brush-O', 'strokes-O', '.-O']
['Areas-O', 'of-O', 'secondary-O', 'hyperalgesia-B-Disease', 'and-O', 'allodynia-B-Disease', 'were-O', 'quantified-O', 'immediately-O', 'after-O', 'injection-O', 'and-O', 'after-O', '15-O', ',-O', '30-O', 'and-O', '60-O', 'min-O', '.-O']
['Two-O', 'identical-O', 'experiments-O', 'separated-O', 'by-O', 'at-O', 'least-O', '7-O', 'days-O', 'were-O', 'performed-O', '.-O']
['Reproducibility-O', 'across-O', 'and-O', 'within-O', 'volunteers-O', '(-O', 'inter-O', ',-O', 'and-O', 'intra-O', ',-O', 'individual-O', 'variation-O', ',-O', 'respectively-O', ')-O', 'was-O', 'assessed-O', 'using-O', 'intraclass-O', 'correlation-O', 'coefficient-O', '(-O', 'ICC-O', ')-O', 'and-O', 'coefficient-O', 'of-O', 'variation-O', '(-O', 'CV-O', ')-O', '.-O', 'Secondary-B-Disease', 'pinprick-O', 'hyperalgesia-I-Disease', 'was-O', 'observed-O', 'as-O', 'a-O', 'marked-O', 'increase-O', 'in-O', 'the-O', 'visual-O', 'analogue-O', 'scale-O', '(-O', 'VAS-O', ')-O', 'response-O', 'to-O', 'von-O', 'Frey-O', 'gauges-O', '60-O', 'and-O', '100-O', 'g-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ')-O', 'after-O', 'glutamate-B-Chemical', 'injection-O', '.-O']
['For-O', 'capsaicin-B-Chemical', ',-O', 'secondary-O', 'pinprick-O', 'hyperalgesia-B-Disease', 'was-O', 'detected-O', 'with-O', 'all-O', 'von-O', 'Frey-O', 'gauges-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'Glutamate-B-Chemical', 'evoked-O', 'reproducible-O', 'VAS-O', 'response-O', 'to-O', 'all-O', 'von-O', 'Frey-O', 'gauges-O', '(-O', 'ICC-O', '>-O', '0-O', '.-O']
['60-O', ')-O', 'and-O', 'brush-O', 'strokes-O', '(-O', 'ICC-O', '>-O', '0-O', '.-O']
['83-O', ').-O', 'Capsaicin-B-Chemical', 'injection-O', 'was-O', 'reproducible-O', 'for-O', 'secondary-B-Disease', 'hyperalgesia-B-Disease', '(-O', 'ICC-O', '>-O', '0-O', '.-O']
['70-O', ')-O', 'and-O', 'allodynia-B-Disease', '(-O', 'ICC-O', '>O', '0-O', '.-O']
['71-O', ').-O', 'Intra-O', ',-O', 'individual-O', 'variability-O', 'was-O', 'generally-O', 'lower-O', 'for-O', 'the-O', 'VAS-O', 'response-O', 'to-O', 'von-O', 'Frey-O', 'and-O', 'brush-O', 'compared-O', 'with-O', 'areas-O', 'of-O', 'secondary-O', 'hyperalgesia-B-Disease', 'and-O', 'allodynia-B-Disease', '.-O']
['In-O', 'conclusion-O', ',-O', 'glutamate-B-Chemical', 'and-O', 'capsaicin-B-Chemical', 'yield-O', 'reproducible-O', 'hyperalgesic-B-Disease', 'and-O', 'allodynic-B-Disease']
['Ocular-B-Disease', ',-O', 'specific-O', 'ER-O', 'stress-O', 'reduction-O', 'rescues-O', 'glaucoma-B-Disease', 'in-O', 'murine-O', 'glucocorticoid-O', ',-O', 'induced-O', 'glaucoma-B-Disease', '.-O']
['Administration-O', 'of-O', 'glucocorticoids-B-Chemical', 'induces-O', 'ocular-B-Disease', 'hypertension-I-Disease', 'in-O', 'some-O', 'patients-O', '.-O']
['If-O', 'untreated-O', ',-O', 'these-O', 'patients-O', 'can-O', 'develop-O', 'a-O', 'secondary-O', 'glaucoma-B-Disease', 'that-O', 'resembles-O', 'primary-O', 'open-angle-O', 'glaucoma-B-Disease', '(-O', 'POAG-B-Disease', ')-O', '.-O', 'The-O', 'underlying-O', 'pathology-O', 'of-O', 'glucocorticoid-B-Chemical', ',-O', 'induced-O', 'glaucoma-B-Disease', 'is-O', 'not-O', 'fully-O', 'understood-O', ',-O', 'due-O', 'in-O', 'part-O', 'to-O', 'lack-O', 'of-O', 'an-O', 'appropriate-O', 'animal-O', 'model-O', '.-O']
['Here-O', ',-O', 'we-O', 'developed-O', 'a-O', 'murine-O', 'model-O', 'of-O', 'glucocorticoid-O', ',-O', 'induced-O', 'glaucoma-B-Disease', 'that-O', 'exhibits-O', 'glaucoma-B-Disease', 'features-O', 'that-O', 'are-O', 'observed-O', 'in-O', 'patients-O', '.-O']
['Treatment-O', 'of-O', 'WT-O', 'mice-O', 'with-O', 'topical-O', 'ocular-O', '0-O', '.-O']
['1-O', '%-O', 'dexamethasone-B-Chemical', 'led-O', 'to-O', 'elevation-O', 'of-O', 'intraocular-O', 'pressure-O', '(-O', 'IOP-O', '),,-O', 'functional-O', 'and-O', 'structural-O', 'loss-O', 'of-O', 'retinal-O', 'ganglion-O', 'cells-O', ',-O', 'and-O', 'axonal-O', 'degeneration-O', ',-O', 'resembling-O', 'glucocorticoid-O', ',-O', 'induced-O', 'glaucoma-B-Disease', 'in-O', 'human-O', 'patients-O', '.-O']
['Furthermore-O', ',-O', 'dexamethasone-B-Chemical', ',-O', 'induced-O', 'ocular-O', 'hypertension-B-Disease', 'was-O', 'associated-O', 'with-O', 'chronic-O', 'ER-O', 'stress-O', 'of-O', 'the-O', 'trabecular-O', 'meshwork-O', '(-O', 'TM-O', ')-O', 'Similar-O', 'to-O', 'patients-O', ',-O', 'withdrawal-O', 'of-O', 'dexamethasone-B-Chemical', 'treatment-O', 'reduced-O', 'elevated-O', 'IOP-O', 'and-O', 'ER-O', 'stress-O', 'in-O', 'this-O', 'animal-O', 'model-O', '.-O']
['Dexamethasone-B-Chemical', 'induced-O', 'the-O', 'transcriptional-O', 'factor-O', 'CHOP-O', ',-O', 'a-O', 'marker-O', 'for-O', 'chronic-O', 'ER-O', 'stress-O', ',-O', 'in-O', 'the-O', 'anterior-O', 'segment-O', 'tissues-O', ',-O', 'and-O', 'Chop-O', 'deletion-O', 'reduced-O', 'ER-O', 'stress-O', 'in-O', 'these-O', 'tissues-O', 'and-O', 'prevented-O', 'dexamethasone-B-Chemical', ',-O', 'induced-O', 'ocular-O', 'hypertension-B-Disease', '.-O']
['Furthermore-O', ',-O', 'reduction-O', 'of-O', 'ER-O', 'stress-O', 'in-O', 'the-O', 'TM-O', 'with-O', 'sodium-B-Chemical', '4-phenylbutyrate-B-Chemical', 'prevented-O', 'dexamethasone-B-Chemical', ',-O', 'induced-O', 'ocular-B-Disease', 'hypertension-B-Disease', 'in-O', 'WT-O', 'mice-O', '.-O']
['Our-O', 'data-O', 'indicate-O', 'that-O', 'ER-O', 'stress-O', 'contributes-O', 'to-O', 'glucocorticoid-O', ',-O', 'induced-O', 'ocular-B-Disease', 'hypertension-B-Disease', 'and-O', 'suggest-O', 'that-O', 'reducing-O', 'ER-O', 'stress-O', 'has-O', 'potential-O', 'as-O', 'a-O', 'therapeutic-O', 'strategy-O', 'for-O', 'treating-O', 'glucocorticoid-O', ',-O', 'induced-O', 'glaucoma-B-Disease']
['Effects-O', 'of-O', 'ginsenosides-B-Chemical', 'on-O', 'opioid-O', ',-O', 'induced-O', 'hyperalgesia-B-Disease', 'in-O', 'mice-O', '.-O']
['Opioid-B-Chemical', ',-O', 'induced-O', 'hyperalgesia-B-Disease', '(-O', 'OIH-O', ')-O', 'is-O', 'characterized-O', 'by-O', 'nociceptive-O', 'sensitization-O', 'caused-O', 'by-O', 'the-O', 'cessation-O', 'of-O', 'chronic-O', 'opioid-B-Chemical', 'use-O', '.-O']
['OIH-O', 'can-O', 'limit-O', 'the-O', 'clinical-O', 'use-O', 'of-O', 'opioid-O', 'analgesics-O', 'and-O', 'complicate-O', 'withdrawal-O', 'from-O', 'opioid-B-Disease', 'addiction-B-Disease', '.-O']
['In-O', 'this-O', 'study-O', ',-O', 'we-O', 'investigated-O', 'the-O', 'effects-O', 'of-O', 'Re-O', 'Rg1-B-Chemical', ',-O', 'and-O', 'Rb1-B-Chemical', 'ginsenosides-O', ',-O', 'the-O', 'bioactive-O', 'components-O', 'of-O', 'ginseng-O', ',-O', 'on-O', 'OIH-B-Disease', '.-O']
['OIH-B-Disease', 'was-O', 'achieved-O', 'in-O', 'mice-O', 'after-O', 'subcutaneous-O', 'administration-O', 'of-O', 'morphine-B-Chemical', 'for-O', '7-O', 'consecutive-O', 'days-O', 'three-O', 'times-O', 'per-O', 'day-O', '.-O']
['During-O', 'withdrawal-O', '(-O', 'days-O', '8-O', 'and-O', '9-O', ')-O', 'these-O', 'mice-O', 'were-O', 'administered-O', 'Re-B-Chemical', ',-O', 'Rg1-B-Chemical', ',-O', 'or-O', 'Rb1-B-Chemical', 'intragastrically-O', 'two-O', 'times-O', 'per-O', 'day-O', '.-O']
['On-O', 'the-O', 'test-O', 'day-O', '(-O', 'day-O', '10-O', ')-O', 'mice-O', 'were-O', 'subjected-O', 'to-O', 'the-O', 'thermal-O', 'sensitivity-O', 'test-O', 'and-O', 'the-O', 'acetic-O', 'acid-B-Chemical', ',-O', 'induced-O', 'writhing-O', 'test-O', '.-O']
['Re-B-Chemical', '(-O', '300-O', 'mg-O', '/-O', 'kg-O', ')-O', 'inhibited-O', 'OIH-B-Disease', 'in-O', 'both-O', 'the-O', 'thermal-O', 'sensitivity-O', 'test-O', 'and-O', 'the-O', 'acetic-O', 'acid-O', ',-O', 'induced-O', 'writhing-O', 'test-O', '.-O']
['However-O', ',-O', 'the-O', 'Rg1-B-Chemical', 'and-O', 'Rb1-B-Chemical', 'ginsenosides-O', 'failed-O', 'to-O', 'prevent-O', 'OIH-B-Disease', 'in-O', 'either-O', 'test-O', '.-O']
['Furthermore-O', ',-O', 'Rg1-B-Chemical', 'showed-O', 'a-O', 'tendency-O', 'to-O', 'aggravate-O', 'OIH-B-Disease', 'in-O', 'the-O', 'acetic-O', 'acid-O', ',-O', 'induced-O', 'writhing-O', 'test-O', '.-O']
['Our-O', 'data-O', 'suggested-O', 'that-O', 'the-O', 'ginsenoside-B-Chemical', 'Re-B-Chemical', ',-O', 'but-O', 'not-O', 'Rg1-B-Chemical', 'or-O', 'Rb1-B-Chemical', ',-O', 'may-O', 'contribute-O', 'toward-O', 'reversal-O', 'of-O', 'OIH-B-Disease']
['A-O', 'comparison-O', 'of-O', 'severe-O', 'hemodynamic-O', 'disturbances-O', 'between-O', 'dexmedetomidine-B-Chemical', 'and-O', 'propofol-B-Chemical', 'for-O', 'sedation-O', 'in-O', 'neurocritical-O', 'care-O', 'patients-O', '.-O']
['OBJECTIVE-O', ':-O', 'Dexmedetomidine-B-Chemical', 'and-O', 'propofol-B-Chemical', 'are-O', 'commonly-O', 'used-O', 'sedatives-O', 'in-O', 'neurocritical-O', 'care-O', 'as-O', 'they-O', 'allow-O', 'for-O', 'frequent-O', 'neurologic-O', 'examinations-O', '.-O']
['However-O', ',-O', 'both-O', 'agents-O', 'are-O', 'associated-O', 'with-O', 'significant-O', 'hemodynamic-O', 'side-O', 'effects-O', '.-O']
['The-O', 'primary-O', 'objective-O', 'of-O', 'this-O', 'study-O', 'is-O', 'to-O', 'compare-O', 'the-O', 'prevalence-O', 'of-O', 'severe-O', 'hemodynamic-O', 'effects-O', 'in-O', 'neurocritical-O', 'care-O', 'patients-O', 'receiving-O', 'dexmedetomidine-B-Chemical', 'and-O', 'propofol-B-Chemical', '.-O']
['DESIGN-O', ':-O', 'Multicenter-O', ',-O', 'retrospective-O', ',-O', 'propensity-O', ',-O', 'matched-O', 'cohort-O', 'study-O', '.-O']
['SETTING-O', ':-O', 'Neurocritical-O', 'care-O', 'units-O', 'at-O', 'two-O', 'academic-O', 'medical-O', 'centers-O', 'with-O', 'dedicated-O', 'neurocritical-O', 'care-O', 'teams-O', 'and-O', 'board-O', ',-O', 'certified-O', 'neurointensivists-O', '.-O']
['PATIENTS-O', ':-O', 'Neurocritical-O', 'care-O', 'patients-O', 'admitted-O', 'between-O', 'July-O', '2009-O', 'and-O', 'September-O', '2012-O', 'were-O', 'evaluated-O', 'and-O', 'then-O', 'matched-O', '1-O', ':-O', '1-O', 'based-O', 'on-O', 'propensity-O', 'scoring-O', 'of-O', 'baseline-O', 'characteristics-O', '.-O']
['INTERVENTIONS-O', ':-O', 'Continuous-O', 'sedation-O', 'with-O', 'dexmedetomidine-B-Chemical', 'or-O', 'propofol-B-Chemical', '.-O']
['MEASUREMENTS-O', 'AND-O', 'MAIN-O', 'RESULTS-O', ':-O', 'A-O', 'total-O', 'of-O', '342-O', 'patients-O', '(-O', '105-O', 'dexmedetomidine-B-Chemical', 'and-O', '237-O', 'propofol-B-Chemical', ')-O', 'were-O', 'included-O', 'in-O', 'the-O', 'analysis-O', ',-O', 'with-O', '190-O', 'matched-O', '(-O', '95-O', 'in-O', 'each-O', 'group-O', ')-O', 'by-O', 'propensity-O', 'score-O', '.-O']
['The-O', 'primary-O', 'outcome-O', 'of-O', 'this-O', 'study-O', 'was-O', 'a-O', 'composite-O', 'of-O', 'severe-O', 'hypotension-B-Disease', '(-O', 'mean-O', 'arterial-O', 'pressure-O', '<-O', '60-O', 'mm-O', 'Hg-O', ')-O', 'and-O', 'bradycardia-B-Disease', '(-O', 'heart-O', 'rate-O', '<-O', '50-O', 'beats-O', '/-O', 'min-O', ')-O', 'during-O', 'sedative-O', 'infusion-O', '.-O']
['No-O', 'difference-O', 'in-O', 'the-O', 'primary-O', 'composite-O', 'outcome-O', 'in-O', 'both-O', 'the-O', 'unmatched-O', '(-O', '30-O', '%-O', 'vs-O', '30-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['94-O', ')-O', 'or-O', 'matched-O', 'cohorts-O', '(-O', '28-O', '%-O', 'vs-O', '34-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['35-O', ')-O', 'could-O', 'be-O', 'found-O', '.-O']
['When-O', 'analyzed-O', 'separately-O', ',-O', 'no-O', 'differences-O', 'could-O', 'be-O', 'found-O', 'in-O', 'the-O', 'prevalence-O', 'of-O', 'severe-O', 'hypotension-B-Disease', 'or-O', 'bradycardia-B-Disease', 'in-O', 'either-O', 'the-O', 'unmatched-O', 'or-O', 'matched-O', 'cohorts-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Severe-O', 'hypotension-B-Disease', 'and-O', 'bradycardia-B-Disease', 'occur-O', 'at-O', 'similar-O', 'prevalence-O', 'in-O', 'neurocritical-O', 'care-O', 'patients-O', 'who-O', 'receive-O', 'dexmedetomidine-B-Chemical', 'or-O', 'propofol-B-Chemical', '.-O']
['Providers-O', 'should-O', 'similarly-O', 'consider-O', 'the-O', 'likelihood-O', 'of-O', 'hypotension-B-Disease', 'or-O', 'bradycardia-B-Disease']
['Hydroxytyrosol-B-Chemical', 'ameliorates-O', 'oxidative-O', 'stress-O', 'and-O', 'mitochondrial-O', 'dysfunction-O', 'in-O', 'doxorubicin-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', 'in-O', 'rats-O', 'with-O', 'breast-B-Disease', 'cancer-I-Disease', '.-O']
['Oxidative-O', 'stress-O', 'is-O', 'involved-O', 'in-O', 'several-O', 'processes-O', 'including-O', 'cancer-B-Disease', ',-O', 'aging-O', 'and-O', 'cardiovascular-B-Disease', 'disease-I-Disease', ',-O', 'and-O', 'has-O', 'been-O', 'shown-O', 'to-O', 'potentiate-O', 'the-O', 'therapeutic-O', 'effect-O', 'of-O', 'drugs-O', 'such-O', 'as-O', 'doxorubicin-B-Chemical', '.-O']
['Doxorubicin-B-Chemical', 'causes-O', 'significant-O', 'cardiotoxicity-B-Disease', 'characterized-O', 'by-O', 'marked-O', 'increases-O', 'in-O', 'oxidative-O', 'stress-O', 'and-O', 'mitochondrial-O', 'dysfunction-B-Disease', '.-O']
['Herein-O', ',-O', 'we-O', 'investigate-O', 'whether-O', 'doxorubicin-B-Chemical', ',-O', 'associated-O', 'chronic-O', 'cardiac-B-Disease', 'toxicity-O', 'can-O', 'be-O', 'ameliorated-O', 'with-O', 'the-O', 'antioxidant-O', 'hydroxytyrosol-B-Chemical', 'in-O', 'rats-O', 'with-O', 'breast-B-Disease', 'cancer-I-Disease', '.-O']
['Thirty-O', ',-O', 'six-O', 'rats-O', 'bearing-O', 'breast-O', 'tumors-I-Disease', 'induced-O', 'chemically-O', 'were-O', 'divided-O', 'into-O', '4-O', 'groups-O', ':-O', 'control-O', ',-O', 'hydroxytyrosol-B-Chemical', '(-O', '0-O', '.-O']
['5mg-O', '/-O', 'kg-O', ',-O', '5days-O', '/-O', 'week-O', ')-O', 'doxorubicin-B-Chemical', '(-O', '1mg-O', '/-O', 'kg-O', '/-O', 'week-O', ')-O', 'and-O', 'doxorubicin-B-Chemical', 'plus-O', 'hydroxytyrosol-B-Chemical', '.-O']
['Cardiac-O', 'disturbances-O', 'at-O', 'the-O', 'cellular-O', 'and-O', 'mitochondrial-O', 'level-O', ',-O', 'mitochondrial-O', 'electron-O', 'transport-O', 'chain-O', 'complexes-O', 'I-O', ',-O', 'IV-O', 'and-O', 'apoptosis-O', ',-O', 'inducing-O', 'factor-O', ',-O', 'and-O', 'oxidative-O', 'stress-O', 'markers-O', 'have-O', 'been-O', 'analyzed-O', '.-O']
['Hydroxytyrosol-B-Chemical', 'improved-O', 'the-O', 'cardiac-O', 'disturbances-O', 'enhanced-O', 'by-O', 'doxorubicin-B-Chemical', 'by-O', 'significantly-O', 'reducing-O', 'the-O', 'percentage-O', 'of-O', 'altered-O', 'mitochondria-O', 'and-O', 'oxidative-O', 'damage-O', '.-O']
['These-O', 'results-O', 'suggest-O', 'that-O', 'hydroxytyrosol-B-Chemical', 'improve-O', 'the-O', 'mitochondrial-O', 'electron-O', 'transport-O', 'chain-O', '.-O']
['This-O', 'study-O', 'demonstrates-O', 'that-O', 'hydroxytyrosol-B-Chemical', 'protect-O', 'rat-O', 'heart-O', 'damage-O', 'provoked-O', 'by-O', 'doxorubicin-B-Chemical']
['Amiodarone-B-Chemical', ',-O', 'induced-O', 'myxoedema-B-Disease', 'coma-B-Disease', '.-O']
['A-O', '62-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'was-O', 'found-O', 'to-O', 'have-O', 'bradycardia-B-Disease', ',-O', 'hypothermia-B-Disease', 'and-O', 'respiratory-B-Disease', 'failure-I-Disease', '3-O', 'weeks-O', 'after-O', 'initiation-O', 'of-O', 'amiodarone-B-Chemical', 'therapy-O', 'for-O', 'atrial-B-Disease', 'fibrillation-I-Disease', '.-O']
['Thyroid-O', ',-O', 'stimulating-O', 'hormone-O', 'was-O', 'found-O', 'to-O', 'be-O', '168-O', 'uIU-O', '/-O', 'mL-O', '(-O', 'nl-O', '.-O']
['0-O', '.-O']
['3-O', '-O', '5-O', 'uIU-O', '/-O', 'mL-O', ')-O', 'and-O', 'free-O', 'thyroxine-B-Chemical', '(-O', 'FT4-O', ')-O', 'was-O', '<-O', '0-O', '.-O']
['2-O', 'ng-O', '/-O', 'dL-O', '(-O', 'nl-O', '.-O']
['0-O', '.-O']
['8-O', ',-O', '1-O', '.-O']
['8-O', 'ng-O', '/-O', 'dL-O', ').-O', 'He-O', 'received-O', 'intravenous-O', 'fluids-O', ',-O', 'vasopressor-O', 'therapy-O', 'and-O', 'stress-O', 'dose-O', 'steroids-B-Chemical', ';-O', 'he-O', 'was-O', 'intubated-O', 'and-O', 'admitted-O', 'to-O', 'the-O', 'intensive-O', 'care-O', 'unit-O', '.-O']
['He-O', 'received-O', '500-O', 'ug-O', 'of-O', 'intravenous-O', 'levothyroxine-B-Chemical', 'in-O', 'the-O', 'first-O', '18-O', 'h-O', 'of-O', 'therapy-O', ',-O', 'and-O', '150-O', 'ug-O', 'intravenous-O', 'daily-O', 'thereafter-O', '.-O']
['Haemodynamic-O', 'improvement-O', ',-O', 'along-O', 'with-O', 'complete-O', 'recovery-O', 'of-O', 'mental-O', 'status-O', ',-O', 'occurred-O', 'after-O', '48-O', 'h-O', '.-O']
['Twelve-O', 'hours-O', 'after-O', 'the-O', 'initiation-O', 'of-O', 'therapy-O', ',-O', 'FT4-B-Chemical', 'was-O', '0-O', '.-O']
['96-O', 'ng-O', '/-O', 'dL-O', '.-O']
['The-O', 'patient-O', 'was-O', 'maintained-O', 'on-O', 'levothyroxine-B-Chemical', '175-O', '(-O', 'g-O', 'POorally-O', 'daily-O', '.-O']
['A-O', 'thyroid-O', 'ultrasound-O', 'showed-O', 'diffuse-O', 'heterogeneity-B-Disease', '.-O']
['The-O', '24-O', 'hour-O', 'excretion-O', 'of-O', 'iodine-B-Chemical', 'was-O', '3657-O', '(-O', 'mcg-O', '(-O', '25-O', ',', '756-O', '(-O', 'mcg-O', ').-O', 'The-O', 'only-O', 'two-O', 'cases-O', 'of-O', 'amiodarone-B-Chemical', ',-O', 'induced-O', 'myxoedema-B-Disease', 'coma-I-Disease', 'in-O', 'the-O', 'literature-O', 'report-O', 'patient-O', 'death-O', 'despite-O', 'supportive-O', 'therapy-O', 'and-O', 'thyroid-O', 'hormone-O', 'replacement-O', '.-O']
['This-O', 'case-O', 'represents-O', 'the-O', 'most-O', 'thoroughly-O', 'investigated-O', 'case-O', 'of-O', 'amiodarone-B-Chemical', ',-O', 'induced-O', 'myxoedema-B-Disease', 'coma-O', 'with-O', 'a-O', 'history-O', 'significant-O', 'for-O', 'subclinical-O', 'thyroid-B-Disease', 'disease-I-Disease']
['Use-O', 'of-O', 'argatroban-B-Chemical', 'and-O', 'catheter-O', ',-O', 'directed-O', 'thrombolysis-O', 'with-O', 'alteplase-B-Chemical', 'in-O', 'an-O', 'oncology-O', 'patient-O', 'with-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', 'with-O', 'thrombosis-B-Disease', '.-O']
['PURPOSE-O', ':-O', 'The-O', 'case-O', 'of-O', 'an-O', 'oncology-O', 'patient-O', 'who-O', 'developed-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', 'with-O', 'thrombosis-B-Disease', '(-O', 'HITT-B-Disease', ')-O', 'and-O', 'was-O', 'treated-O', 'with-O', 'argatroban-B-Chemical', 'plus-O', 'catheter-O', ',-O', 'directed-O', 'thrombolysis-O', '(-O', 'CDT-O', ')-O', 'with-O', 'alteplase-B-Chemical', 'is-O', 'presented-O', '.-O']
['SUMMARY-O', ':-O', 'A-O', '63-O', ',-O', 'year-O', ',-O', 'old-O', 'Caucasian-O', 'man-O', 'with-O', 'renal-O', 'amyloidosis-B-Disease', 'undergoing-O', 'peripheral-O', 'blood-O', 'stem-O', 'cell-O', 'collection-O', 'for-O', 'an-O', 'autologous-O', 'stem-O', 'cell-O', 'transplant-O', 'developed-O', 'extensive-O', 'bilateral-O', 'upper-extremity-O', 'deep-O', 'venous-O', 'thrombosis-B-Disease', '(-O', 'DVT-B-Disease', ')-O', 'and-O', 'pulmonary-O', 'embolism-B-Disease', 'secondary-O', 'to-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', '.-O']
['A-O', 'continuous-O', 'i-O', '.-O']
['v-O', '.-O']
['infusion-O', 'of-O', 'argatroban-B-Chemical', 'was-O', 'initiated-O', ',-O', 'and-O', 'the-O', 'patient-O', 'was-O', 'managed-O', 'on-O', 'the-O', 'general-O', 'medical-O', 'floor-O', '.-O']
['After-O', 'one-O', 'week-O', 'of-O', 'therapy-O', ',-O', 'he-O', 'was-O', 'transferred-O', 'to-O', 'the-O', 'intensive-O', 'care-O', 'unit-O', 'with-O', 'cardiopulmonary-O', 'compromise-O', 'related-O', 'to-O', 'superior-O', 'vena-O', 'cava-O', '(SVC)-O', 'syndrome-B-Disease', '.-O']
['A-O', 'percutaneous-O', 'mechanical-O', 'thrombectomy-O', 'and-O', 'CDT-O', 'with-O', 'alteplase-B-Chemical', 'were-O', 'attempted-O', ',-O', 'but-O', 'the-O', 'procedure-O', 'was-O', 'aborted-O', 'due-O', 'to-O', 'epistaxis-B-Disease', '.-O']
['The-O', 'epistaxis-B-Disease', 'resolved-O', 'the-O', 'next-O', 'day-O', ',-O', 'and-O', 'the-O', 'patient-O', 'was-O', 'restarted-O', 'on-O', 'argatroban-B-Chemical', '.-O']
['A-O', 'second-O', 'percutaneous-O', 'mechanical-O', 'thrombectomy-O', 'was-O', 'performed-O', 'six-O', 'days-O', 'later-O', 'and-O', 'resulted-O', 'in-O', 'partial-O', 'revascularization-O', 'of-O', 'the-O', 'SVC-B-Disease', 'and-O', 'central-O', 'veins-O', '.-O']
['Postthrombectomy-O', 'continuous-O', 'CDT-O', 'with-O', 'alteplase-B-Chemical', 'was-O', 'commenced-O', 'while-O', 'argatroban-B-Chemical', 'was-O', 'withheld-O', ',-O', 'and-O', 'complete-O', 'patency-O', 'of-O', 'the-O', 'SVC-O', 'and-O', 'central-O', 'veins-O', 'was-O', 'achieved-O', 'after-O', 'three-O', 'days-O', 'of-O', 'therapy-O', '.-O']
['Alteplase-B-Chemical', 'was-O', 'discontinued-O', ',-O', 'and-O', 'the-O', 'patient-O', 'was-O', 'reinitiated-O', 'on-O', 'argatroban-B-Chemical', ';-O', 'ultimately-O', ',-O', 'he-O', 'was-O', 'transitioned-O', 'to-O', 'warfarin-B-Chemical', 'for-O', 'long-O', ',-O', 'term-O', 'anticoagulation-O', '.-O']
['Although-O', 'the-O', 'patient-O', 'recovered-O', ',-O', 'he-O', 'experienced-O', 'permanent-O', 'vision-B-Disease', 'and-O', 'hearing-B-Disease', 'loss-I-Disease', ',-O', 'as-O', 'well-O', 'as-O', 'end-stage-B-Disease', 'renal-I-Disease', 'disease-I-Disease', '.-O']
['CONCLUSION-O', ':-O', 'A-O', '63-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'with-O', 'renal-O', 'amyloidosis-B-Disease', 'and-O', 'SVC-B-Disease', 'syndrome-I-Disease', 'secondary-O', 'to-O', 'HITT-B-Disease', 'was-O', 'successfully-O', 'treated-O', 'with-O', 'argatroban-B-Chemical']
['Effects-O', 'of-O', 'dehydroepiandrosterone-B-Chemical', 'in-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'schizophrenia-B-Disease', 'models-O', 'in-O', 'mice-O', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'examine-O', 'the-O', 'effects-O', 'of-O', 'dehydroepiandrosterone-B-Chemical', '(-O', 'DHEA-B-Chemical', ')-O', 'on-O', 'animal-O', 'models-O', 'of-O', 'schizophrenia-B-Disease', '.-O']
['METHODS-O', ':-O', 'Seventy-O', 'Swiss-O', 'albino-O', 'female-O', 'mice-O', '(-O', '25-O', ',-O', '35-O', 'g-O', ')-O', 'were-O', 'divided-O', 'into-O', '4-O', 'groups-O', ':-O', 'amphetamine-B-Chemical', ',-O', 'free-O', '(-O', 'control-O', ')-O', 'amphetamine-B-Chemical', ',-O', '50-O', ',-O', 'and-O', '100-O', 'mg-O', '/-O', 'kg-O', 'DHEA-B-Chemical', '.-O']
['The-O', 'DHEA-B-Chemical', 'was-O', 'administered-O', 'intraperitoneally-O', '(-O', 'ip-O', ')-O', 'for-O', '5-O', 'days-O', '.-O']
['Amphetamine-B-Chemical', '(-O', '3-O', 'mg-O', '/-O', 'kg-O', 'ip-O', ')-O', 'induced-O', 'hyper-O', 'locomotion-B-Disease', ',-O', 'apomorphine-B-Chemical', '(-O', '1-O', '.-O']
['5-O', 'mg-O', '/-O', 'kg-O', 'subcutaneously-O', '[', 'sc-O', '])', 'induced-O', 'climbing-O', ',-O', 'and-O', 'haloperidol-B-Chemical', '(-O', '1-O', '.-O']
['5-O', 'mg-O', '/-O', 'kg-O', 'sc-O', ')-O', 'induced-O', 'catalepsy-B-Disease', 'tests-O', 'were-O', 'used-O', 'as-O', 'animal-O', 'models-O', 'of-O', 'schizophrenia-B-Disease', '.-O']
['The-O', 'study-O', 'was-O', 'conducted-O', 'at-O', 'the-O', 'Animal-O', 'Experiment-O', 'Laboratories-O', ',-O', 'Department-O', 'of-O', 'Pharmacology-O', ',-O', 'Medical-O', 'School-O', ',-O', 'Eskisehir-O', 'Osmangazi-O', 'University-O', ',-O', 'Eskisehir-O', ',-O', 'Turkey-O', 'between-O', 'March-O', 'and-O', 'May-O', '2012-O', '.-O']
['Statistical-O', 'analysis-O', 'was-O', 'carried-O', 'out-O', 'using-O', 'Kruskal-O', ',-O', 'Wallis-O', 'test-O', 'for-O', 'hyper-O', 'locomotion-O', ',-O', 'and-O', 'one-O', ',-O', 'way-O', 'ANOVA-O', 'for-O', 'climbing-O', 'and-O', 'catalepsy-B-Disease', 'tests-O', '.-O']
['RESULTS-O', ':-O', 'In-O', 'the-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'locomotion-O', 'test-O', ',-O', 'there-O', 'were-O', 'significant-O', 'increases-O', 'in-O', 'all-O', 'movements-O', 'compared-O', 'with-O', 'the-O', 'amphetamine-B-Chemical', ',-O', 'free-O', 'group-O', '.-O']
['Both-O', 'DHEA-B-Chemical', '50-O', 'mg-O', '/-O', 'kg-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ')-O', ',', 'and-O', '100-O', 'mg-O', '/-O', 'kg-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'significantly-O', 'decreased-O', 'all-O', 'movements-O', 'compared-O', 'with-O', 'the-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'locomotion-O', 'group-O', '.-O']
['There-O', 'was-O', 'a-O', 'significant-O', 'difference-O', 'between-O', 'groups-O', 'in-O', 'the-O', 'haloperidol-B-Chemical', ',-O', 'induced-O', 'catalepsy-B-Disease', 'test-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'There-O', 'was-O', 'no-O', 'significant-O', 'difference-O', 'between-O', 'groups-O', 'in-O', 'terms-O', 'of-O', 'total-O', 'climbing-O', 'time-O', 'in-O', 'the-O', 'apomorphine-B-Chemical', ',-O', 'induced-O', 'climbing-O', 'test-O', '(-O', 'p-O', '>-O', '0-O', '.-O']
['05-O', ').-O', 'CONCLUSION-O', ':-O', 'We-O', 'observed-O', 'that-O', 'DHEA-B-Chemical', 'reduced-O', 'locomotor-O', 'activity-O', 'and-O', 'increased-O', 'catalepsy-B-Disease', 'at-O', 'both-O', 'doses-O', ',-O', 'while-O', 'it-O', 'had-O', 'no-O', 'effect-O', 'on-O', 'climbing-O', 'behavior-O', '.-O']
['We-O', 'suggest-O', 'that-O', 'DHEA-B-Chemical', 'displays-O', 'typical-O', 'neuroleptic-O', ',-O', 'like-O', 'effects-O', ',-O', 'and-O', 'may-O', 'be-O', 'used-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'schizophrenia-B-Disease']
['Availability-O', 'of-O', 'human-O', 'induced-O', 'pluripotent-O', 'stem-O', 'cell-O', ',-O', 'derived-O', 'cardiomyocytes-O', 'in-O', 'assessment-O', 'of-O', 'drug-O', 'potential-O', 'for-O', 'QT-O', 'prolongation-O', '.-O']
['Field-O', 'potential-O', 'duration-O', '(-O', 'FPD-O', ')-O', 'in-O', 'human-O', ',-O', 'induced-O', 'pluripotent-O', 'stem-O', 'cell-O', ',-O', 'derived-O', 'cardiomyocytes-O', '(-O', 'hiPS-O', '-O', 'CMs-O', ')-O', 'which-O', 'can-O', 'express-O', 'QT-O', 'interval-O', 'in-O', 'an-O', 'electrocardiogram-O', ',-O', 'is-O', 'reported-O', 'to-O', 'be-O', 'a-O', 'useful-O', 'tool-O', 'to-O', 'predict-O', 'K-O', '-O', 'channel-O', 'and-O', 'Ca-O', '(-O', '2-O', ')-O', 'channel-O', 'blocker-O', 'effects-O', 'on-O', 'QT-O', 'interval-O', '.-O']
['However-O', ',-O', 'there-O', 'is-O', 'no-O', 'report-O', 'showing-O', 'that-O', 'this-O', 'technique-O', 'can-O', 'be-O', 'used-O', 'to-O', 'predict-O', 'multichannel-O', 'blocker-O', 'potential-O', 'for-O', 'QT-O', 'prolongation-B-Disease', '.-O']
['The-O', 'aim-O', 'of-O', 'this-O', 'study-O', 'is-O', 'to-O', 'show-O', 'that-O', 'FPD-O', 'from-O', 'MEA-O', '(-O', 'Multielectrode-O', 'array-O', ')-O', 'of-O', 'hiPS-O', ',-O', 'CMs-O', 'can-O', 'detect-O', 'QT-O', 'prolongation-B-Disease', 'induced-O', 'by-O', 'multichannel-O', 'blockers-O', '.-O']
['hiPS-O', ',-O', 'CMs-O', 'were-O', 'seeded-O', 'onto-O', 'MEA-O', 'and-O', 'FPD-O', 'was-O', 'measured-O', 'for-O', '2min-O', 'every-O', '10min-O', 'for-O', '30min-O', 'after-O', 'drug-O', 'exposure-O', 'for-O', 'the-O', 'vehicle-O', 'and-O', 'each-O', 'drug-O', 'concentration-O', '.-O']
['IKr-O', 'and-O', 'IKs-O', 'blockers-O', 'concentration-O', ',-O', 'dependently-O', 'prolonged-O', 'corrected-O', 'FPD-O', '(-O', 'FPDc-O', ')-O', 'whereas-O', 'Ca-B-Chemical', '(-O', '2-O', ')-O', 'channel-O', 'blockers-O', 'concentration-O', ',-O', 'dependently-O', 'shortened-O', 'FPDc-O', '.-O']
['Also-O', ',-O', 'the-O', 'multichannel-O', 'blockers-O', 'Amiodarone-B-Chemical', ',-O', 'Paroxetine-B-Chemical', ',-O', 'Terfenadine-B-Chemical', 'and-O', 'Citalopram-B-Chemical', 'prolonged-O', 'FPDc-O', 'in-O', 'a-O', 'concentration-O', 'dependent-O', 'manner-O', '.-O']
['Finally-O', ',', 'the-O', 'IKr-O', 'blockers-O', ',', 'Terfenadine-B-Chemical', 'and-O', 'Citalopram-B-Chemical', ',', 'which-O', 'are-O', 'reported-O', 'to-O', 'cause-O', 'Torsade-B-Disease', 'de-I-Disease', 'Pointes-I-Disease', '(-O', 'TdP-B-Disease', ')-O', 'in-O', 'clinical-O', 'practice-O', ',', 'produced-O', 'early-O', 'afterdepolarization-O', '(-O', 'EAD-O', ').-O', 'hiPS-O', ',', 'CMs-O', 'using-O', 'MEA-O', 'system-O', 'and-O', 'FPDc-O', 'can-O', 'predict-O', 'the-O', 'effects-O', 'of-O', 'drug-O', 'candidates-O', 'on-O', 'QT-O', 'interval-O', '.-O']
['This-O', 'study-O', 'also-O', 'shows-O', 'that-O', 'this-O', 'assay-O', 'can-O', 'help-O', 'detect-O', 'EAD-B-Disease', 'for-O', 'drugs-O', 'with-O', 'TdP-B-Disease']
['Dermal-O', 'developmental-O', 'toxicity-B-Disease', 'of-O', 'N-B-Chemical', ',-O', 'phenylimide-B-Chemical', 'herbicides-B-Chemical', 'in-O', 'rats-O', '.-O']
['BACKGROUND-O', ':-O', 'S-53482-B-Chemical', 'and-O', 'S-23121-B-Chemical', 'are-O', 'N-O', ',', 'phenylimide-O', 'herbicides-O', 'and-O', 'produced-O', 'embryolethality-O', ',', 'teratogenicity-O', '(-O', 'mainly-O', 'ventricular-B-Disease', 'septal-I-Disease', 'defects-I-Disease', 'and-O', 'wavy-O', 'ribs-O', ')-O', ',', 'and-O', 'growth-O', 'retardation-O', 'in-O', 'rats-O', 'in-O', 'conventional-O', 'oral-O', 'developmental-O', 'toxicity-O', 'studies-O', '.-O']
['Our-O', 'objective-O', 'in-O', 'this-O', 'study-O', 'was-O', 'to-O', 'investigate-O', 'whether-O', 'the-O', 'compounds-O', 'induce-O', 'developmental-O', 'toxicity-B-Disease', 'via-O', 'the-O', 'dermal-O', 'route-O', ',-O', 'which-O', 'is-O', 'more-O', 'relevant-O', 'to-O', 'occupational-O', 'exposure-O', ',-O', 'hence-O', 'better-O', 'addressing-O', 'human-O', 'health-O', 'risks-O', '.-O']
['METHODS-O', ':-O', 'S-53482-B-Chemical', 'was-O', 'administered-O', 'dermally-O', 'to-O', 'rats-O', 'at-O', '30-O', ',-O', '100-O', ',-O', 'and-O', '300-O', 'mg-O', '/-O', 'kg-O', 'during-O', 'organogenesis-O', ',-O', 'and-O', 'S-23121-B-Chemical', 'was-O', 'administered-O', 'at-O', '200-O', ',-O', '400-O', ',-O', 'and-O', '800-O', 'mg-O', '/-O', 'kg-O', '(-O', 'the-O', 'maximum-O', 'applicable-O', 'dose-O', 'level-O', ')-O', '.-O', 'Fetuses-O', 'were-O', 'obtained-O', 'by-O', 'a-O', 'Cesarean-O', 'section-O', 'and-O', 'examined-O', 'for-O', 'external-O', ',-O', 'visceral-O', ',-O', 'and-O', 'skeletal-O', 'alterations-O', '.-O']
['RESULTS-O', ':-O', 'Dermal-O', 'exposure-O', 'of-O', 'rats-O', 'to-O', 'S-53482-B-Chemical', 'at-O', '300-O', 'mg-O', '/-O', 'kg-O', 'produced-O', 'patterns-O', 'of-O', 'developmental-O', 'toxicity-B-Disease', 'similar-O', 'to-O', 'those-O', 'resulting-O', 'from-O', 'oral-O', 'exposure-O', '.-O']
['Toxicity-B-Disease', 'included-O', 'embryolethality-B-Disease', ',-O', 'teratogenicity-B-Disease', ',-O', 'and-O', 'growth-O', 'retardation-B-Disease', '.-O']
['Dermal-O', 'administration-O', 'of-O', 'S-23121-B-Chemical', 'at-O', '800-O', 'mg-O', '/-O', 'kg-O', 'resulted-O', 'in-O', 'an-O', 'increased-O', 'incidence-O', 'of-O', 'embryonic-O', 'death-B-Disease', 'and-O', 'ventricular-B-Disease', 'septal-I-Disease', 'defect-I-Disease', ',-O', 'but-O', 'retarded-O', 'fetal-O', 'growth-O', 'was-O', 'not-O', 'observed-O', 'as-O', 'it-O', 'was-O', 'following-O', 'oral-O', 'exposure-O', 'to-O', 'S-23121-B-Chemical', '.-O']
['CONCLUSIONS-O', ':-O', 'Based-O', 'on-O', 'the-O', 'results-O', ',-O', 'S-53482-B-Chemical', 'and-O', 'S-23121-B-Chemical', 'were-O', 'teratogenic-O']
['Rates-O', 'of-O', 'Renal-B-Disease', 'Toxicity-I-Disease', 'in-O', 'Cancer-B-Disease', 'Patients-O', 'Receiving-O', 'Cisplatin-B-Chemical', 'With-O', 'and-O', 'Without-O', 'Mannitol-B-Chemical', '.-O']
['BACKGROUND-O', ':-O', 'Cisplatin-B-Chemical', 'is-O', 'a-O', 'widely-O', 'used-O', 'antineoplastic-O', '.-O']
['One-O', 'of-O', 'the-O', 'major-O', 'complications-O', 'of-O', 'cisplatin-B-Chemical', 'use-O', 'is-O', 'dose-O', ',-O', 'limiting-O', 'nephrotoxicity-B-Disease', '.-O']
['There-O', 'are-O', 'many-O', 'strategies-O', 'to-O', 'prevent-O', 'this-O', 'toxicity-O', ',-O', 'including-O', 'the-O', 'use-O', 'of-O', 'mannitol-B-Chemical', 'as-O', 'a-O', 'nephroprotectant-O', 'in-O', 'combination-O', 'with-O', 'hydration-O', '.-O']
['OBJECTIVE-O', ':-O', 'We-O', 'aimed-O', 'to-O', 'evaluate-O', 'the-O', 'rates-O', 'of-O', 'cisplatin-B-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease', 'in-O', 'cancer-B-Disease', 'patients-O', 'receiving-O', 'single-O', ',-O', 'agent-O', 'cisplatin-B-Chemical', 'with-O', 'and-O', 'without-O', 'mannitol-B-Chemical', '.-O']
['METHODS-O', ':-O', 'This-O', 'single-O', 'center-O', 'retrospective-O', 'analysis-O', 'was-O', 'a-O', 'quasi-O', 'experiment-O', 'created-O', 'by-O', 'the-O', 'national-O', 'mannitol-B-Chemical', 'shortage-O', '.-O']
['Data-O', 'were-O', 'collected-O', 'on-O', 'adult-O', 'cancer-B-Disease', 'patients-O', 'receiving-O', 'single-O', ',-O', 'agent-O', 'cisplatin-B-Chemical', 'as-O', 'an-O', 'outpatient-O', 'from-O', 'January-O', '2011-O', 'to-O', 'September-O', '2012-O', '.-O']
['The-O', 'primary-O', 'outcome-O', 'was-O', 'acute-B-Disease', 'kidney-O', 'injury-I-Disease', '(-O', 'AKI-B-Disease', ').-O', 'RESULTS-O', ':-O', 'We-O', 'evaluated-O', '143-O', 'patients-O', 'who-O', 'received-O', 'single-O', ',-O', 'agent-O', 'cisplatin-B-Chemical', ';-O', '97-O', '.-O']
['2-O', '%-O', 'of-O', 'patients-O', 'had-O', 'head-B-Disease', 'and-I-Disease', 'neck-I-Disease', 'cancer-I-Disease', 'as-O', 'their-O', 'primary-O', 'malignancy-O', '.-O']
['Patients-O', 'who-O', 'did-O', 'not-O', 'receive-O', 'mannitol-B-Chemical', 'were-O', 'more-O', 'likely-O', 'to-O', 'develop-O', 'nephrotoxicity-B-Disease', ':-O', 'odds-O', 'ratio-O', '[', 'OR-O', ']=-O', '2-O', '.-O']
['646-O', '(-O', '95-O', '%-O', 'CI-O', '=', '1-O', '.-O']
['008-O', ',-O', '6-O', '.-O']
['944-O', ';-O', 'P-O', '=', '0-O', '.-O']
['048-O', ').-O', 'Patients-O', 'who-O', 'received-O', 'the-O', '100-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'dosing-O', 'and-O', 'patients-O', 'who-O', 'had-O', 'a-O', 'history-O', 'of-O', 'hypertension-B-Disease', 'also-O', 'had-O', 'a-O', 'higher-O', 'likelihood-O', 'of-O', 'developing-O', 'nephrotoxicity-B-Disease', ':-O', 'OR-O', '=-O', '11-O', '.-O']
['494-O', '(-O', '95-O', '%-O', 'CI-O', '='-O', '4-O', '.-O']
['149-O', ',-O', '32-O', '.-O']
['258-O', ';-O', 'P-O', '<-O', '0-O', '.-O']
['0001-O', ')-O', 'and-O', 'OR-O', '=-O', '3-O', '.-O']
['219-O', '(-O', '95-O', '%-O', 'CI-O', '=', '1-O', '.-O']
['228-O', ',-O', '8-O', '.-O']
['439-O', ';-O', 'P-O', '=', '0-O', '.-O']
['017-O', ',-O', 'respectively-O', '.-O']
['CONCLUSIONS-O', ':-O', 'When-O', 'limited-O', 'quantities-O', 'of-O', 'mannitol-B-Chemical', 'are-O', 'available-O', ',-O', 'it-O', 'should-O', 'preferentially-O', 'be-O', 'given-O', 'to-O', 'patients-O', 'at-O', 'particularly-O', 'high-O', 'risk-O', 'of-O', 'nephrotoxicity-B-Disease', '.-O']
['Our-O', 'analysis-O', 'suggests-O', 'that-O', 'those-O', 'patients-O', 'receiving-O', 'the-O', 'dosing-O', 'schedule-O', 'of-O', '100-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'cisplatin-B-Chemical', 'every-O', '3-O', 'weeks-O', 'and-O', 'those-O', 'with-O', 'hypertension-B-Disease', 'are-O', 'at-O', 'the-O', 'greatest-O', 'risk-O', 'of-O', 'nephrotoxicity-B-Disease', 'and-O', 'would-O', 'benefit-O', 'from-O', 'the-O', 'addition-O', 'of-O', 'mannitol-B-Chemical']
['Metformin-B-Chemical', 'protects-O', 'against-O', 'seizures-B-Disease', ',-O', 'learning-O', 'and-O', 'memory-O', 'impairments-O', 'and-O', 'oxidative-O', 'damage-O', 'induced-O', 'by-O', 'pentylenetetrazole-B-Chemical', ',-O', 'induced-O', 'kindling-O', 'in-O', 'mice-O', '.-O']
['Cognitive-B-Disease', 'impairment-I-Disease', ',-O', 'the-O', 'most-O', 'common-O', 'and-O', 'severe-O', 'comorbidity-O', 'of-O', 'epilepsy-B-Disease', ',-O', 'greatly-O', 'diminishes-O', 'the-O', 'quality-O', 'of-O', 'life-O', '.-O']
['However-O', ',-O', 'current-O', 'therapeutic-O', 'interventions-O', 'for-O', 'epilepsy-B-Disease', 'can-O', 'also-O', 'cause-O', 'untoward-O', 'cognitive-O', 'effects-O', '.-O']
['Thus-O', ',-O', 'there-O', 'is-O', 'an-O', 'urgent-O', 'need-O', 'for-O', 'new-O', 'kinds-O', 'of-O', 'agents-O', 'targeting-O', 'both-O', 'seizures-B-Disease', 'and-O', 'cognition-O', 'deficits-B-Disease', '.-O']
['Oxidative-O', 'stress-O', 'is-O', 'considered-O', 'to-O', 'play-O', 'an-O', 'important-O', 'role-O', 'in-O', 'epileptogenesis-O', 'and-O', 'cognitive-O', 'deficits-O', ',-O', 'and-O', 'antioxidants-O', 'have-O', 'a-O', 'putative-O', 'antiepileptic-O', 'potential-O', '.-O']
['Metformin-B-Chemical', ',-O', 'the-O', 'most-O', 'commonly-O', 'prescribed-O', 'antidiabetic-O', 'oral-O', 'drug-O', ',-O', 'has-O', 'antioxidant-O', 'properties-O', '.-O']
['This-O', 'study-O', 'was-O', 'designed-O', 'to-O', 'evaluate-O', 'the-O', 'ameliorative-O', 'effects-O', 'of-O', 'metformin-B-Chemical', 'on-O', 'seizures-B-Disease', ',-O', 'cognitive-B-Disease', 'impairment-I-Disease', 'and-O', 'brain-O', 'oxidative-O', 'stress-O', 'markers-O', 'observed-O', 'in-O', 'pentylenetetrazole-B-Chemical', ',-O', 'induced-O', 'kindling-O', 'animals-O', '.-O']
['Male-O', 'C57BL-O', '/-O', '6-O', 'mice-O', 'were-O', 'administered-O', 'with-O', 'subconvulsive-O', 'dose-O', 'of-O', 'pentylenetetrazole-B-Chemical', '(-O', '37-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', ')-O', 'every-O', 'other-O', 'day-O', 'for-O', '14-O', 'injections-O', '.-O']
['Metformin-B-Chemical', 'was-O', 'injected-O', 'intraperitoneally-O', 'in-O', 'dose-O', 'of-O', '200mg-O', '/-O', 'kg-O', 'along-O', 'with-O', 'alternate-O', ',-O', 'day-O', 'PTZ-B-Chemical', '.-O']
['We-O', 'found-O', 'that-O', 'metformin-B-Chemical', 'suppressed-O', 'the-O', 'progression-O', 'of-O', 'kindling-O', ',-O', 'ameliorated-O', 'the-O', 'cognitive-B-Disease', 'impairment-I-Disease', 'and-O', 'decreased-O', 'brain-O', 'oxidative-O', 'stress-O', '.-O']
['Thus-O', 'the-O', 'present-O', 'study-O', 'concluded-O', 'that-O', 'metformin-B-Chemical', 'may-O', 'be-O', 'a-O', 'potential-O', 'agent-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'epilepsy-B-Disease', 'as-O', 'well-O', 'as-O', 'a-O', 'protective-O', 'medicine-O', 'against-O', 'cognitive-B-Disease', 'impairment-I-Disease', 'induced-O', 'by-O', 'seizures-B-Disease']
['P53-O', 'inhibition-O', 'exacerbates-O', 'late-O', ',-O', 'stage-O', 'anthracycline-B-Chemical', 'cardiotoxicity-B-Disease', '.-O']
['AIMS-O', ':-O', 'Doxorubicin-B-Chemical', '(-O', 'DOX-B-Chemical', ')-O', 'is-O', 'an-O', 'effective-O', 'anti-O', ',-O', 'cancer-O', 'therapeutic-O', ',-O', 'but-O', 'is-O', 'associated-O', 'with-O', 'both-O', 'acute-O', 'and-O', 'late-O', ',-O', 'stage-O', 'cardiotoxicity-B-Disease', '.-O']
['Children-O', 'are-O', 'particularly-O', 'sensitive-O', 'to-O', 'DOX-B-Chemical', ',-O', 'induced-O', 'heart-B-Disease', 'failure-I-Disease', '.-O']
['Here-O', ',-O', 'the-O', 'impact-O', 'of-O', 'p53-B-Chemical', 'inhibition-O', 'on-O', 'acute-O', 'vs-O', '.-O']
['late-O', ',-O', 'stage-O', 'DOX-B-Chemical', 'cardiotoxicity-B-Disease', 'was-O', 'examined-O', 'in-O', 'a-O', 'juvenile-O', 'model-O', '.-O']
['METHODS-O', 'AND-O', 'RESULTS-O', ':-O', 'Two-O', ',-O', 'week-O', ',-O', 'old-O', 'MHC-O', ',-O', 'CB7-O', 'mice-O', '(-O', 'which-O', 'express-O', 'dominant-O', ',-O', 'interfering-O', 'p53-O', 'in-O', 'cardiomyocytes-O', ')-O', 'and-O', 'their-O', 'non-O', ',-O', 'transgenic-O', '(-O', 'NON-O', ',-O', 'TXG-O', ')-O', 'littermates-O', 'received-O', 'weekly-O', 'DOX-B-Chemical', 'injections-O', 'for-O', '5-O', 'weeks-O', '(-O', '25-O', 'mg-O', '/-O', 'kg-O', 'cumulative-O', 'dose-O', ')-O', '.-O', 'One-O', 'week-O', 'after-O', 'the-O', 'last-O', 'DOX-B-Chemical', 'treatment-O', '(-O', 'acute-O', 'stage-O', ')-O', ',-O', 'MHC-O', ',-O', 'CB7-O', 'mice-O', 'exhibited-O', 'improved-O', 'cardiac-O', 'function-O', 'and-O', 'lower-O', 'levels-O', 'of-O', 'cardiomyocyte-O', 'apoptosis-O', 'when-O', 'compared-O', 'with-O', 'the-O', 'NON-O', ',-O', 'TXG-O', 'mice-O', '.-O']
['Surprisingly-O', ',-O', 'by-O', '13-O', 'weeks-O', 'following-O', 'the-O', 'last-O', 'DOX-B-Chemical', 'treatment-O', '(-O', 'late-O', 'stage-O', ')-O', 'MHC-O', ',-O', 'CB7-O', 'exhibited-O', 'a-O', 'progressive-O', 'decrease-O', 'in-O', 'cardiac-O', 'function-O', 'and-O', 'higher-O', 'rates-O', 'of-O', 'cardiomyocyte-O', 'apoptosis-B-Disease', 'when-O', 'compared-O', 'with-O', 'NON-O', ',-O', 'TXG-O', 'mice-O', '.-O']
['p53-O', 'inhibition-O', 'blocked-O', 'transient-O', 'DOX-B-Chemical', ',-O', 'induced-O', 'STAT3-O', 'activation-O', 'in-O', 'MHC-O', ',-O', 'CB7-O', 'mice-O', ',-O', 'which-O', 'was-O', 'associated-O', 'with-O', 'enhanced-O', 'induction-O', 'of-O', 'the-O', 'DNA-O', 'repair-O', 'proteins-O', 'Ku70-O', 'and-O', 'Ku80-O', '.-O']
['Mice-O', 'with-O', 'cardiomyocyte-O', ',-O', 'restricted-O', 'deletion-O', 'of-O', 'STAT3-B-Chemical', 'exhibited-O', 'worse-O', 'cardiac-O', 'function-O', ',-O', 'higher-O', 'levels-O', 'of-O', 'cardiomyocyte-O', 'apoptosis-O', ',-O', 'and-O', 'a-O', 'greater-O', 'induction-O', 'of-O', 'Ku70-B-Chemical', 'and-O', 'Ku80-B-Chemical', 'in-O', 'response-O', 'to-O', 'DOX-B-Chemical', 'treatment-O', 'during-O', 'the-O', 'acute-O', 'stage-O', 'when-O', 'compared-O', 'with-O', 'control-O', 'animals-O', '.-O']
['CONCLUSION-O', ':-O', 'These-O', 'data-O', 'support-O', 'a-O', 'model-O', 'wherein-O', 'a-O', 'p53-O', ',-O', 'dependent-O', 'cardioprotective-O', 'pathway-O', ',-O', 'mediated-O', 'via-O', 'STAT3-O', 'activation-O', ',-O', 'mitigates-O', 'DOX-B-Chemical', ',-O', 'induced-O', 'myocardial-B-Disease', 'stress-O', 'during-O', 'drug-O', 'delivery-O', '.-O']
['Furthermore-O', ',-O', 'these-O', 'data-O', 'suggest-O', 'an-O', 'explanation-O', 'as-O', 'to-O', 'how-O', 'p53-O', 'inhibition-O', 'can-O', 'result-O', 'in-O', 'cardioprotection-O', 'during-O', 'drug-O', 'treatment-O', 'and-O', ',-O', 'paradoxically-O', ',-O', 'enhanced-O', 'cardiotoxicity-B-Disease']
['Metronidazole-B-Chemical', ',-O', 'induced-O', 'encephalopathy-B-Disease', ':-O', 'an-O', 'uncommon-O', 'scenario-O', '.-O']
['Metronidazole-B-Chemical', 'can-O', 'produce-O', 'neurological-B-Disease', 'complications-I-Disease', 'although-O', 'it-O', 'is-O', 'not-O', 'a-O', 'common-O', 'scenario-O', '.-O']
['We-O', 'present-O', 'a-O', 'case-O', 'where-O', 'a-O', 'patient-O', 'developed-O', 'features-O', 'of-O', 'encephalopathy-B-Disease', 'following-O', 'prolonged-O', 'metronidazole-B-Chemical', 'intake-O', '.-O']
['Magnetic-O', 'resonance-O', 'imaging-O', '(-O', 'MRI-O', ')-O', 'brain-O', 'showed-O', 'abnormal-O', 'signal-O', 'intensity-O', 'involving-O', 'both-O', 'dentate-O', 'nuclei-O', 'of-O', 'cerebellum-O', 'and-O', 'splenium-O', 'of-O', 'corpus-O', 'callosum-O', '.-O']
['The-O', 'diagnosis-O', 'of-O', 'metronidazole-B-Chemical', 'toxicity-O']
['Aconitine-B-Chemical', ',-O', 'induced-O', 'Ca-B-Chemical', '2-O', '+-O', 'overload-O', 'causes-O', 'arrhythmia-B-Disease', 'and-O', 'triggers-O', 'apoptosis-O', 'through-O', 'p38-O', 'MAPK-O', 'signaling-O', 'pathway-O', 'in-O', 'rats-O', '.-O']
['Aconitine-B-Chemical', 'is-O', 'a-O', 'major-O', 'bioactive-O', 'diterpenoid-O', 'alkaloid-O', 'with-O', 'high-O', 'content-O', 'derived-O', 'from-O', 'herbal-O', 'aconitum-O', 'plants-O', '.-O']
['Emerging-O', 'evidence-O', 'indicates-O', 'that-O', 'voltage-O', 'dependent-O', 'Na-B-Chemical', ',-O', 'channels-O', 'have-O', 'pivotal-O', 'roles-O', 'in-O', 'the-O', 'cardiotoxicity-B-Disease', 'of-O', 'aconitine-B-Chemical', '.-O']
['However-O', ',-O', 'no-O', 'reports-O', 'are-O', 'available-O', 'on-O', 'the-O', 'role-O', 'of-O', 'Ca-B-Chemical', '(-O', '2-O', ')-O', 'in-O', 'aconitine-B-Chemical', 'poisoning-O', '.-O']
['In-O', 'this-O', 'study-O', ',-O', 'we-O', 'explored-O', 'the-O', 'importance-O', 'of-O', 'pathological-O', 'Ca-B-Chemical', '(-O', '2-O', ')-O', 'signaling-O', 'in-O', 'aconitine-B-Chemical', 'poisoning-B-Disease', 'in-O', 'vitro-O', 'and-O', 'in-O', 'vivo-O', '.-O']
['We-O', 'found-O', 'that-O', 'Ca-B-Chemical', '(-O', '2-O', ')-O', 'overload-O', 'lead-O', 'to-O', 'accelerated-O', 'beating-O', 'rhythm-O', 'in-O', 'adult-O', 'rat-O', 'ventricular-O', 'myocytes-O', 'and-O', 'caused-O', 'arrhythmia-B-Disease', 'in-O', 'conscious-O', 'freely-O', 'moving-O', 'rats-O', '.-O']
['To-O', 'investigate-O', 'effects-O', 'of-O', 'aconitine-B-Chemical', 'on-O', 'myocardial-B-Disease', 'injury-I-Disease', ',-O', 'we-O', 'performed-O', 'cytotoxicity-O', 'assay-O', 'in-O', 'neonatal-O', 'rat-O', 'ventricular-O', 'myocytes-O', '(-O', 'NRVMs-O', '),', 'as-O', 'well-O', 'as-O', 'measured-O', 'lactate-B-Chemical', 'dehydrogenase-O', 'level-O', 'in-O', 'the-O', 'culture-O', 'medium-O', 'of-O', 'NRVMs-O', 'and-O', 'activities-O', 'of-O', 'serum-O', 'cardiac-O', 'enzymes-O', 'in-O', 'rats-O', '.-O']
['The-O', 'results-O', 'showed-O', 'that-O', 'aconitine-B-Chemical', 'resulted-O', 'in-O', 'myocardial-B-Disease', 'injury-I-Disease', 'and-O', 'reduced-O', 'NRVMs-O', 'viability-O', 'dose-O', ',-O', 'dependently-O', '.-O']
['To-O', 'confirm-O', 'the-O', 'pro-O', ',-O', 'apoptotic-O', 'effects-O', ',-O', 'we-O', 'performed-O', 'flow-O', 'cytometric-O', 'detection-O', ',-O', 'cardiac-O', 'histology-O', ',-O', 'transmission-O', 'electron-O', 'microscopy-O', 'and-O', 'terminal-O', 'deoxynucleotidyl-O', 'transferase-O', ',-O', 'mediated-O', 'dUTP-O', ',-O', 'biotin-O', 'nick-O', 'end-O', 'labeling-O', 'assay-O', '.-O']
['The-O', 'results-O', 'showed-O', 'that-O', 'aconitine-B-Chemical', 'stimulated-O', 'apoptosis-B-Disease', 'time-O', ',-O', 'dependently-O', '.-O']
['The-O', 'expression-O', 'analysis-O', 'of-O', 'Ca-B-Chemical', '(-O', '2-O', ')-O', 'handling-O', 'proteins-O', 'demonstrated-O', 'that-O', 'aconitine-B-Chemical', 'promoted-O', 'Ca-B-Chemical', '(-O', '2-O', ')-O', 'overload-O', 'through-O', 'the-O', 'expression-O', 'regulation-O', 'of-O', 'Ca-B-Chemical', '(-O', '2-O', ')-O', 'handling-O', 'proteins-O', '.-O']
['The-O', 'expression-O', 'analysis-O', 'of-O', 'apoptosis-O', ',-O', 'related-O', 'proteins-O', 'revealed-O', 'that-O', 'pro-O', ',-O', 'apoptotic-O', 'protein-O', 'expression-O', 'was-O', 'upregulated-O', ',-O', 'and-O', 'anti-O', ',-O', 'apoptotic-O', 'protein-O', 'BCL-O', ',-O', '2-O', 'expression-O', 'was-O', 'downregulated-O', '.-O']
['Furthermore-O', ',-O', 'increased-O', 'phosphorylation-O', 'of-O', 'MAPK-O', 'family-O', 'members-O', ',-O', 'especially-O', 'the-O', 'P-O', ',-O', 'P38-O', '/-O', 'P38-O', 'ratio-O', 'was-O', 'found-O', 'in-O', 'cardiac-O', 'tissues-O', '.-O']
['Hence-O', ',-O', 'our-O', 'results-O', 'suggest-O', 'that-O', 'aconitine-B-Chemical', 'significantly-O', 'aggravates-O', 'Ca-B-Chemical', '(-O', '2-O', ')', 'overload-O', 'and-O', 'causes-O', 'arrhythmia-B-Disease']
['Chronic-O', 'treatment-O', 'with-O', 'metformin-B-Chemical', 'suppresses-O', 'toll-O', 'like-O', 'receptor-O', '4-O', 'signaling-O', 'and-O', 'attenuates-O', 'left-O', 'ventricular-O', 'dysfunction-O', 'following-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['Acute-O', 'treatment-O', 'with-O', 'metformin-B-Chemical', 'has-O', 'a-O', 'protective-O', 'effect-O', 'in-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'by-O', 'suppression-O', 'of-O', 'inflammatory-O', 'responses-O', 'due-O', 'to-O', 'activation-O', 'of-O', 'AMP-B-Chemical', ',-O', 'activated-O', 'protein-O', 'kinase-O', '(-O', 'AMPK-B-Chemical', ').-O', 'In-O', 'the-O', 'present-O', 'study-O', ',-O', 'the-O', 'effect-O', 'of-O', 'chronic-O', 'pre-O', ',-O', 'treatment-O', 'with-O', 'metformin-B-Chemical', 'on-O', 'cardiac-O', 'dysfunction-O', 'and-O', 'toll-O', ',-O', 'like-O', 'receptor-O', '4-O', '(-O', 'TLR4-B-Chemical', ')-O', 'activities-O', 'following-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'and-O', 'their-O', 'relation-O', 'with-O', 'AMPK-B-Chemical', 'were-O', 'assessed-O', '.-O']
['Male-O', 'Wistar-O', 'rats-O', 'were-O', 'randomly-O', 'assigned-O', 'to-O', 'one-O', 'of-O', '5-O', 'groups-O', '(-O', 'n-O', '=-O', '6-O', '):-O', 'normal-O', 'control-O', 'and-O', 'groups-O', 'were-O', 'injected-O', 'isoproterenol-B-Chemical', 'after-O', 'chronic-O', 'pre-O', 'treatment-O', 'with-O', '0-O', ',-O', '25-O', ',-O', '50-O', ',-O', 'or-O', '100mg-O', '/-O', 'kg-O', 'of-O', 'metformin-B-Chemical', 'twice-O', 'daily-O', 'for-O', '14-O', 'days-O', '.-O']
['Isoproterenol-B-Chemical', '(-O', '100mg-O', '/-O', 'kg-O', ')-O', 'was-O', 'injected-O', 'subcutaneously-O', 'on-O', 'the-O', '13th-O', 'and-O', '14th-O', 'days-O', 'to-O', 'induce-O', 'acute-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['Isoproterenol-B-Chemical', 'alone-O', 'decreased-O', 'left-O', 'ventricular-O', 'systolic-O', 'pressure-O', 'and-O', 'myocardial-O', 'contractility-O', 'indexed-O', 'as-O', 'LVdp-O', '/-O', 'dtmax-O', 'and-O', 'LVdp-O', '/-O', 'dtmin-O', '.-O']
['The-O', 'left-O', 'ventricular-O', 'dysfunction-I-Disease', 'was-O', 'significantly-O', 'lower-O', 'in-O', 'the-O', 'groups-O', 'treated-O', 'with-O', '25-O', 'and-O', '50mg-O', '/-O', 'kg-O', 'of-O', 'metformin-B-Chemical', '.-O']
['Metfromin-B-Chemical', 'markedly-O', 'lowered-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'elevation-O', 'in-O', 'the-O', 'levels-O', 'of-O', 'TLR4-O', 'mRNA-O', ',-O', 'myeloid-O', 'differentiation-O', 'protein-O', '88-O', '(-O', 'MyD88-O', '),', 'tumor-O', 'necrosis-O', 'factor-O', ',-O', 'alpha-O', '(-O', 'TNF-O', ',-O', 'a-O', '),', 'and-O', 'interleukin-O', '6-O', '(-O', 'IL-O', ',-O', '6-O', ')', 'in-O', 'the-O', 'heart-O', 'tissues-O', '.-O']
['Similar-O', 'changes-O', 'were-O', 'also-O', 'seen-O', 'in-O', 'the-O', 'serum-O', 'levels-O', 'of-O', 'TNF-B-Chemical', ',-O', 'a-O', 'and-O', 'IL-B-Chemical', ',-O', '6-O', '.-O']
['However-O', ',-O', 'the-O', 'lower-O', 'doses-O', 'of-O', '25-O', 'and-O', '50mg-O', '/-O', 'kg-O', 'were-O', 'more-O', 'effective-O', 'than-O', '100mg-O', '/-O', 'kg-O', '.-O']
['Phosphorylated-O', 'AMPKa-O', '(-O', 'p-O', ',-O', 'AMPK-O', ')-O', 'in-O', 'the-O', 'myocardium-O', 'was-O', 'significantly-O', 'elevated-O', 'by-O', '25mg-O', '/-O', 'kg-O', 'of-O', 'metformin-B-Chemical', ',-O', 'slightly-O', 'by-O', '50mg-O', '/-O', 'kg-O', ',-O', 'but-O', 'not-O', 'by-O', '100mg-O', '/-O', 'kg-O', '.-O']
['Chronic-O', 'pre-O', ',-O', 'treatment-O', 'with-O', 'metformin-B-Chemical', 'reduces-O', 'post-O', ',-O', 'myocardial-B-Disease', 'infarction-I-Disease']
['Neuroleptic-B-Disease', 'malignant-I-Disease', 'syndrome-I-Disease', 'induced-O', 'by-O', 'combination-O', 'therapy-O', 'with-O', 'tetrabenazine-B-Chemical', 'and-O', 'tiapride-B-Chemical', 'in-O', 'a-O', 'Japanese-O', 'patient-O', 'with-O', 'Huntington-B-Disease', 'disease-I-Disease', 'at-O', 'the-O', 'terminal-O', 'stage-O', 'of-O', 'recurrent-O', 'breast-B-Disease', 'cancer-I-Disease', '.-O']
['We-O', 'herein-O', 'describe-O', 'the-O', 'case-O', 'of-O', 'an-O', '81-O', ',-O', 'year-O', ',-O', 'old-O', 'Japanese-O', 'woman-O', 'with-O', 'neuroleptic-B-Disease', 'malignant-B-Disease', 'syndrome-I-Disease', 'that-O', 'occurred-O', '36-O', 'days-O', 'after-O', 'the-O', 'initiation-O', 'of-O', 'combination-O', 'therapy-O', 'with-O', 'tiapride-B-Chemical', '(-O', '75-O', 'mg-O', '/-O', 'day-O', ')-O', 'and-O', 'tetrabenazine-B-Chemical', '(-O', '12-O', '.-O']
['5-O', 'mg-O', '/-O', 'day-O', ')-O', 'for-O', 'Huntington-B-Disease', 'disease-I-Disease', '.-O']
['The-O', 'patient-O', 'had-O', 'been-O', 'treated-O', 'with-O', 'tiapride-B-Chemical', 'or-O', 'tetrabenazine-B-Chemical', 'alone-O', 'without-O', 'any-O', 'adverse-O', 'effects-O', 'before-O', 'the-O', 'administration-O', 'of-O', 'the-O', 'combination-O', 'therapy-O', '.-O']
['She-O', 'also-O', 'had-O', 'advanced-O', 'breast-B-Disease', 'cancer-I-Disease', 'when-O', 'the-O', 'combination-O', 'therapy-O', 'was-O', 'initiated-O', '.-O']
['To-O', 'the-O', 'best-O', 'of-O', 'our-O', 'knowledge-O', ',-O', 'the-O', 'occurrence-O', 'of-O', 'neuroleptic-B-Disease', 'malignant-O', 'syndrome-I-Disease', 'due-O', 'to-O', 'combination-O', 'therapy-O', 'with-O', 'tetrabenazine-B-Chemical', 'and-O', 'tiapride-B-Chemical', 'has-O', 'not-O', 'been-O', 'previously-O', 'reported-O', '.-O']
['Tetrabenazine-B-Chemical', 'should-O', 'be-O', 'administered-O', 'very-O', 'carefully-O', 'in-O', 'combination-O', 'with-O', 'other-O', 'neuroleptic-O', 'drugs-O']
['A-O', 'metoprolol-B-Chemical', ',-O', 'terbinafine-B-Chemical', 'combination-O', 'induced-O', 'bradycardia-B-Disease', '.-O']
['To-O', 'report-O', 'a-O', 'sinus-B-Disease', 'bradycardia-I-Disease', 'induced-O', 'by-O', 'metoprolol-B-Chemical', 'and-O', 'terbinafine-B-Chemical', 'drug-O', ',-O', 'drug-O', 'interaction-O', 'and-O', 'its-O', 'management-O', '.-O']
['A-O', '63-O', 'year-O', ',-O', 'old-O', 'Caucasian-O', 'man-O', 'on-O', 'metoprolol-B-Chemical', '200-O', 'mg-O', '/-O', 'day-O', 'for-O', 'stable-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease', 'was-O', 'prescribed-O', 'a-O', '90-O', ',-O', 'day-O', 'course-O', 'of-O', 'oral-O', 'terbinafine-B-Chemical', '250-O', 'mg-O', '/-O', 'day-O', 'for-O', 'onychomycosis-B-Disease', '.-O']
['On-O', 'the-O', '49th-O', 'day-O', 'of-O', 'terbinafine-B-Chemical', 'therapy-O', ',-O', 'he-O', 'was-O', 'brought-O', 'to-O', 'the-O', 'emergency-O', 'room-O', 'for-O', 'a-O', 'decrease-O', 'of-O', 'his-O', 'global-O', 'health-O', 'status-O', ',-O', 'confusion-B-Disease', 'and-O', 'falls-B-Disease', '.-O']
['The-O', 'electrocardiogram-O', 'revealed-O', 'a-O', '37-O', 'beats-O', '/-O', 'min-O', 'sinus-B-Disease', 'bradycardia-B-Disease', '.-O']
['A-O', 'score-O', 'of-O', '7-O', 'on-O', 'the-O', 'Naranjo-O', 'adverse-O', 'drug-O', 'reaction-O', 'probability-O', 'scale-O', 'indicates-O', 'a-O', 'probable-O', 'relationship-O', 'between-O', 'the-O', 'patient-O', 'x-O', 's-O', 'sinus-B-Disease', 'bradycardia-I-Disease', 'and-O', 'the-O', 'drug-O', 'interaction-O', 'between-O', 'metoprolol-B-Chemical', 'and-O', 'terbinafine-B-Chemical', '.-O']
['The-O', 'heart-O', 'rate-O', 'ameliorated-O', 'first-O', 'with-O', 'a-O', 'decrease-O', 'in-O', 'the-O', 'dose-O', 'of-O', 'metoprolol-B-Chemical', '.-O']
['It-O', 'was-O', 'subsequently-O', 'changed-O', 'to-O', 'bisoprolol-B-Chemical', 'and-O', 'the-O', 'heart-O', 'rate-O', 'remained-O', 'normal-O', '.-O']
['By-O', 'inhibiting-O', 'the-O', 'cytochrome-O', 'P450-O', '2D6-O', ',-O', 'terbinafine-B-Chemical', 'had-O', 'decreased-O', 'metoprolol-B-Chemical', 'x-O', 's-O', 'clearance-O', ',-O', 'leading-O', 'in-O', 'metoprolol-B-Chemical', 'accumulation-O', 'which-O', 'has-O', 'resulted-O', 'in-O', 'clinically-O', 'significant-O', 'sinus-B-Disease', 'bradycardia-I-Disease']
['Optochiasmatic-B-Disease', 'and-O', 'peripheral-B-Disease', 'neuropathy-I-Disease', 'due-O', 'to-O', 'ethambutol-B-Chemical', 'overtreatment-O', '.-O']
['Ethambutol-B-Chemical', 'is-O', 'known-O', 'to-O', 'cause-O', 'optic-B-Disease', 'neuropathy-I-Disease', 'and-O', ',-O', 'more-O', 'rarely-O', ',-O', 'axonal-O', 'polyneuropathy-B-Disease', '.-O']
['We-O', 'characterize-O', 'the-O', 'clinical-O', ',-O', 'neurophysiological-O', ',-O', 'and-O', 'neuroimaging-O', 'findings-O', 'in-O', 'a-O', '72-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'who-O', 'developed-O', 'visual-B-Disease', 'loss-I-Disease', 'and-O', 'paresthesias-B-Disease', 'after-O', '11-O', 'weeks-O', 'of-O', 'exposure-O', 'to-O', 'a-O', 'supratherapeutic-O', 'dose-O', 'of-O', 'ethambutol-B-Chemical', '.-O']
['This-O', 'case-O', 'demonstrates-O', 'the-O', 'selective-O', 'vulnerability-O', 'of-O', 'the-O', 'anterior-O', 'visual-O', 'pathways-O', 'and-O', 'peripheral-O', 'nerves-O', 'to-O', 'ethambutol-B-Chemical', 'toxicity-O']
['Testosterone-B-Chemical', 'ameliorates-O', 'streptozotocin-B-Chemical', ',-O', 'induced-O', 'memory-B-Disease', 'impairment-I-Disease', 'in-O', 'male-O', 'rats-O', '.-O']
['AIM-O', ':-O', 'To-O', 'study-O', 'the-O', 'effects-O', 'of-O', 'testosterone-B-Chemical', 'on-O', 'streptozotocin-B-Chemical', '(-O', 'STZ-B-Chemical', ')-O', 'induced-O', 'memory-B-Disease', 'impairment-I-Disease', 'in-O', 'male-O', 'rats-O', '.-O']
['METHODS-O', ':-O', 'Adult-O', 'male-O', 'Wistar-O', 'rats-O', 'were-O', 'intracerebroventricularly-O', '(-O', 'icv-O', ')-O', 'infused-O', 'with-O', 'STZ-B-Chemical', '(-O', '750-O', 'ug-O', ')-O', 'on-O', 'd-O', '1-O', 'and-O', 'd-O', '3-O', ',-O', 'and-O', 'a-O', 'passive-O', 'avoidance-O', 'task-O', 'was-O', 'assessed-O', '2-O', 'weeks-O', 'after-O', 'the-O', 'first-O', 'injection-O', 'of-O', 'STZ-B-Chemical', '.-O']
['Castration-O', 'surgery-O', 'was-O', 'performed-O', 'in-O', 'another-O', 'group-O', 'of-O', 'rats-O', ',-O', 'and-O', 'the-O', 'passive-O', 'avoidance-O', 'task-O', 'was-O', 'assessed-O', '4-O', 'weeks-O', 'after-O', 'the-O', 'operation-O', '.-O']
['Testosterone-B-Chemical', '(-O', '1-O', 'mg-O', '.-O']
['kg-O', '(-O', '1-O', ').-O', 'd-O', '(-O', '1-O', '),,-O', 'sc-O', ')-O', 'the-O', 'androgen-O', 'receptor-O', 'antagonist-O', 'flutamide-B-Chemical', '(-O', '10-O', 'mg-O', '.-O']
['kg-O', '(-O', '1-O', ').-O', 'd-O', '(-O', '1-O', '),,-O', 'ip-O', '),-O', 'the-O', 'estrogen-B-Chemical', 'receptor-O', 'antagonist-O', 'tamoxifen-B-Chemical', '(-O', '1-O', 'mg-O', '.-O']
['kg-O', '(-O', '1-O', ').-O', 'd-O', '(-O', '1-O', '),', 'ip-O', ')-O', 'or-O', 'the-O', 'aromatase-O', 'inhibitor-O', 'letrozole-B-Chemical', '(-O', '4-O', 'mg-O', '.-O']
['kg-O', '(-O', '1-O', ').-O', 'd-O', '(-O', '1-O', '),O', 'ip-O', ')-O', 'were-O', 'administered-O', 'for-O', '6-O', 'd-O', 'after-O', 'the-O', 'first-O', 'injection-O', 'of-O', 'STZ-B-Chemical', '.-O']
['RESULTS-O', ':-O', 'STZ-B-Chemical', 'administration-O', 'and-O', 'castration-O', 'markedly-O', 'decreased-O', 'both-O', 'STL1-O', '(-O', 'the-O', 'short-O', 'memory-O', ')-O', 'and-O', 'STL2-O', '(-O', 'the-O', 'long-O', 'memory-O', ')-O', 'in-O', 'passive-O', 'avoidance-O', 'tests-O', '.-O']
['Testosterone-B-Chemical', 'replacement-O', 'almost-O', 'restored-O', 'the-O', 'STL1-O', 'and-O', 'STL2-O', 'in-O', 'castrated-O', 'rats-O', ',-O', 'and-O', 'significantly-O', 'prolonged-O', 'the-O', 'STL1-O', 'and-O', 'STL2-O', 'in-O', 'STZ-O', 'treated-O', 'rats-O', '.-O']
['Administration-O', 'of-O', 'flutamide-B-Chemical', ',-O', 'letrozole-B-Chemical', 'or-O', 'tamoxifen-B-Chemical', 'significantly-O', 'impaired-O', 'the-O', 'memory-O', 'in-O', 'intact-O', 'rats-O', ',-O', 'and-O', 'significantly-O', 'attenuated-O', 'the-O', 'testosterone-B-Chemical', 'replacement-O', 'in-O', 'improving-O', 'STZ-O', ',-O', 'and-O', 'castration-O', ',-O', 'induced-O', 'memory-O', 'impairment-O', '.-O']
['CONCLUSION-O', ':-O', 'Testosterone-B-Chemical', 'administration-O', 'ameliorates-O', 'STZ-O', ',-O', 'and-O', 'castration-O', ',-O', 'induced-O', 'memory-B-Disease', 'impairment-I-Disease']
['Behavioral-O', 'and-O', 'neurochemical-O', 'studies-O', 'in-O', 'mice-O', 'pretreated-O', 'with-O', 'garcinielliptone-B-Chemical', 'FC-O', 'in-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', '.-O']
['Garcinielliptone-B-Chemical', 'FC-B-Chemical', '(-O', 'GFC-B-Chemical', ')', 'isolated-O', 'from-O', 'hexanic-B-Chemical', 'fraction-O', 'seed-O', 'extract-I-Chemical', 'of-O', 'species-O', 'Platonia-I-Chemical', 'insignis-I-Chemical', 'Mart-O', '.-O']
['It-O', 'is-O', 'widely-O', 'used-O', 'in-O', 'folk-O', 'medicine-O', 'to-O', 'treat-O', 'skin-B-Disease', 'diseases-O', 'in-O', 'both-O', 'humans-O', 'and-O', 'animals-O', 'as-O', 'well-O', 'as-O', 'the-O', 'seed-O', 'decoction-O', 'has-O', 'been-O', 'used-O', 'to-O', 'treat-O', 'diarrheas-B-Disease', 'and-O', 'inflammatory-B-Disease', 'diseases-O', '.-O']
['However-O', ',-O', 'there-O', 'is-O', 'no-O', 'research-O', 'on-O', 'GFC-B-Chemical', 'effects-O', 'in-O', 'the-O', 'central-O', 'nervous-O', 'system-O', 'of-O', 'rodents-O', '.-O']
['The-O', 'present-O', 'study-O', 'aimed-O', 'to-O', 'evaluate-O', 'the-O', 'GFC-B-Chemical', 'effects-O', 'at-O', 'doses-O', 'of-O', '25-O', ',-O', '50-O', 'or-O', '75-O', 'mg-O', '/-O', 'kg-O', 'on-O', 'seizure-B-Disease', 'parameters-O', 'to-O', 'determine-O', 'their-O', 'anticonvulsant-O', 'activity-O', 'and-O', 'its-O', 'effects-O', 'on-O', 'amino-B-Chemical', 'acid-I-Chemical', '(-O', 'r-aminobutyric-B-Chemical', 'acid-I-Chemical', '(-O', 'GABA-B-Chemical', '),,-O', 'glutamine-B-Chemical', ',-O', 'aspartate-B-Chemical', 'and-O', 'glutathione-B-Chemical', ')-O', 'levels-O', 'as-O', 'well-O', 'as-O', 'on-O', 'acetylcholinesterase-O', '(-O', 'AChE-O', ')-O', 'activity-O', 'in-O', 'mice-O', 'hippocampus-O', 'after-O', 'seizures-B-Disease', '.-O']
['GFC-B-Chemical', 'produced-O', 'an-O', 'increased-O', 'latency-O', 'to-O', 'first-O', 'seizure-B-Disease', ',-O', 'at-O', 'doses-O', '25mg-O', '/-O', 'kg-O', '(-O', '20-O', '.-O']
['12-O', '+-O', '2-O', '.-O']
['20-O', 'min-O', ')-O', '50mg-O', '/-O', 'kg-O', '(-O', '20-O', '.-O']
['95-O', '+-O', '2-O', '.-O']
['21-O', 'min-O', ')-O', 'or-O', '75-O', 'mg-O', '/-O', 'kg-O', '(-O', '23-O', '.-O']
['43-O', '+-O', '1-O', '.-O']
['99-O', 'min-O', ')-O', 'when-O', 'compared-O', 'with-O', 'seized-O', 'mice-O', '.-O']
['In-O', 'addition-O', ',-O', 'GABA-B-Chemical', 'content-O', 'of-O', 'mice-O', 'hippocampus-O', 'treated-O', 'with-O', 'GFC75-B-Chemical', 'plus-O', 'P400-B-Chemical', 'showed-O', 'an-O', 'increase-O', 'of-O', '46-O', '.-O']
['90-O', '%-O', 'when-O', 'compared-O', 'with-O', 'seized-B-Disease', 'mice-O', '.-O']
['In-O', 'aspartate-B-Chemical', ',-O', 'glutamine-B-Chemical', 'and-O', 'glutamate-B-Chemical', 'levels-O', 'detected-O', 'a-O', 'decrease-O', 'of-O', '5-O', '.-O']
['21-O', ',-O', '13-O', '.-O']
['55-O', '%-O', 'and-O', '21-O', '.-O']
['80-O', ',-O', 'respectively-O', 'in-O', 'mice-O', 'hippocampus-O', 'treated-O', 'with-O', 'GFC75-B-Chemical', 'plus-O', 'P400-B-Chemical', 'when-O', 'compared-O', 'with-O', 'seized-B-Disease', 'mice-O', '.-O']
['Hippocampus-O', 'mice-O', 'treated-O', 'with-O', 'GFC75-B-Chemical', 'plus-O', 'P400-B-Chemical', 'showed-O', 'an-O', 'increase-O', 'in-O', 'AChE-O', 'activity-O', '(-O', '63-O', '.-O']
['30-O', ')-O', 'when-O', 'compared-O', 'with-O', 'seized-O', 'mice-O', '.-O']
['The-O', 'results-O', 'indicate-O', 'that-O', 'GFC-O', 'can-O', 'exert-O', 'anticonvulsant-O', 'activity-O', 'and-O', 'reduce-O', 'the-O', 'frequency-O', 'of-O', 'installation-O', 'of-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'status-B-Disease', 'epilepticus-I-Disease', ',-O', 'as-O', 'demonstrated-O', 'by-O', 'increase-O', 'in-O', 'latency-O', 'to-O', 'first-O', 'seizure-O', 'and-O', 'decrease-O', 'in-O', 'mortality-O', 'rate-O', 'of-O', 'animals-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'our-O', 'data-O', 'suggest-O', 'that-O', 'GFC-B-Chemical', 'may-O', 'influence-O', 'in-O', 'epileptogenesis-O', 'and-O', 'promote-O', 'anticonvulsant-O', 'actions-O', 'in-O', 'pilocarpine-B-Chemical', 'model-O', 'by-O', 'modulating-O', 'the-O', 'GABA-B-Chemical', 'and-O', 'glutamate-B-Chemical']
['Standard-O', 'operating-O', 'procedures-O', 'for-O', 'antibiotic-O', 'therapy-O', 'and-O', 'the-O', 'occurrence-O', 'of-O', 'acute-B-Disease', 'kidney-I-Disease', 'injury-I-Disease', ':-O', 'a-O', 'prospective-O', ',-O', 'clinical-O', ',-O', 'non-O', ',-O', 'interventional-O', ',-O', 'observational-O', 'study-O', '.-O']
['INTRODUCTION-O', ':-O', 'Acute-O', 'kidney-B-Disease', 'injury-I-Disease', '(-O', 'AKI-O', ')-O', 'occurs-O', 'in-O', '7-O', '%-O', 'of-O', 'hospitalized-O', 'and-O', '66-O', '%-O', 'of-O', 'Intensive-O', 'Care-O', 'Unit-O', '(-O', 'ICU-O', ')-O', 'patients-O', '.-O']
['It-O', 'increases-O', 'mortality-O', ',-O', 'hospital-O', 'length-O', 'of-O', 'stay-O', ',-O', 'and-O', 'costs-O', '.-O']
['The-O', 'aim-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'investigate-O', ',-O', 'whether-O', 'there-O', 'is-O', 'an-O', 'association-O', 'between-O', 'adherence-O', 'to-O', 'guidelines-O', '(-O', 'standard-O', 'operating-O', 'procedures-O', '(-O', 'SOP-O', '))-O', 'for-O', 'potentially-O', 'nephrotoxic-O', 'antibiotics-O', 'and-O', 'the-O', 'occurrence-O', 'of-O', 'AKI-B-Disease', '.-O']
['METHODS-O', ':-O', 'This-O', 'study-O', 'was-O', 'carried-O', 'out-O', 'as-O', 'a-O', 'prospective-O', ',-O', 'clinical-O', ',-O', 'non-O', ',-O', 'interventional-O', ',-O', 'observational-O', 'study-O', '.-O']
['Data-O', 'collection-O', 'was-O', 'performed-O', 'over-O', 'a-O', 'total-O', 'of-O', '170-O', 'days-O', 'in-O', 'three-O', 'ICUs-O', 'at-O', 'Charite-O', ',-O', 'Universitaetsmedizin-O', 'Berlin-O', '.-O']
['A-O', 'total-O', 'of-O', '675-O', 'patients-O', 'were-O', 'included-O', ';-O', '163-O', 'of-O', 'these-O', 'had-O', 'therapy-O', 'with-O', 'vancomycin-B-Chemical', ',-O', 'gentamicin-B-Chemical', ',-O', 'or-O', 'tobramycin-B-Chemical', ';-O', 'were-O', '>-O', '18-O', 'years-O', ';-O', 'and-O', 'treated-O', 'in-O', 'the-O', 'ICU-O', 'for-O', '>-O', '24-O', 'hours-O', '.-O']
['Patients-O', 'with-O', 'an-O', 'adherence-O', 'to-O', 'SOP-O', '>-O', '70-O', '%-O', 'were-O', 'classified-O', 'into-O', 'the-O', 'high-O', 'adherence-O', 'group-O', '(-O', 'HAG-O', ')-O', 'and-O', 'patients-O', 'with-O', 'an-O', 'adherence-O', 'of-O', '<-O', '70-O', '%-O', 'into-O', 'the-O', 'low-O', 'adherence-O', 'group-O', '(-O', 'LAG-O', ')-O', '.-O', 'AKI-B-Disease', 'was-O', 'defined-O', 'according-O', 'to-O', 'RIFLE-O', 'criteria-O', '.-O']
['Adherence-O', 'to-O', 'SOPs-O', 'was-O', 'evaluated-O', 'by-O', 'retrospective-O', 'expert-O', 'audit-O', '.-O']
['Development-O', 'of-O', 'AKI-B-Disease', 'was-O', 'compared-O', 'between-O', 'groups-O', 'with-O', 'exact-O', 'Chi2-O', 'test-O', 'and-O', 'multivariate-O', 'logistic-O', 'regression-O', 'analysis-O', '(-O', 'two-O', ',-O', 'sided-O', 'P-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'RESULTS-O', ':-O', 'LAG-O', 'consisted-O', 'of-O', '75-O', 'patients-O', '(-O', '46-O', ')-O', 'versus-O', '88-O', 'HAG-O', 'patients-O', '(-O', '54-O', ')-O', '.-O', 'AKI-B-Disease', 'occurred-O', 'significantly-O', 'more-O', 'often-O', 'in-O', 'LAG-O', 'with-O', '36-O', '%-O', 'versus-O', '21-O', '%-O', 'in-O', 'HAG-O', '(-O', 'P-O', '=-O', '0-O', '.-O']
['035-O', ').-O', 'Basic-O', 'characteristics-O', 'were-O', 'comparable-O', ',-O', 'except-O', 'an-O', 'increased-O', 'rate-O', 'of-O', 'soft-O', 'tissue-O', 'infections-B-Disease', 'in-O', 'LAG-O', '.-O']
['Multivariate-O', 'analysis-O', 'revealed-O', 'an-O', 'odds-O', 'ratio-O', 'of-O', '2-O', '.-O']
['5-O', ',-O', 'fold-O', 'for-O', 'LAG-O', 'to-O', 'develop-O', 'AKI-B-Disease', 'compared-O', 'with-O', 'HAG-O', '(-O', '95-O', '%-O', 'confidence-O', 'interval-O', '1-O', '.-O']
['195-O', 'to-O', '5-O', '.-O']
['124-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['039-O', ').-O', 'CONCLUSION-O', ':-O', 'Low-O', 'adherence-O', 'to-O', 'SOPs-O', 'for-O', 'potentially-O', 'nephrotoxic-B-Disease', 'antibiotics-O', 'was-O', 'associated-O', 'with-O', 'a-O', 'higher-O', 'occurrence-O', 'of-O', 'AKI-B-Disease']
['Rhabdomyolysis-B-Disease', 'in-O', 'a-O', 'hepatitis-B-Disease', 'C-I-Disease', 'virus-I-Disease', 'infected-I-Disease', 'patient-O', 'treated-O', 'with-O', 'telaprevir-B-Chemical', 'and-O', 'simvastatin-B-Chemical', '.-O']
['A-O', '46-O', '--O', 'year-O', 'old-O', 'man-O', 'with-O', 'a-O', 'chronic-B-Disease', 'hepatitis-I-Disease', 'C-I-Disease', 'virus-I-Disease', 'infection-I-Disease', 'received-O', 'triple-O', 'therapy-O', 'with-O', 'ribavirin-B-Chemical', '--O', 'pegylated-B-Chemical', 'interferon-I-Chemical', 'and-O', 'telaprevir-B-Chemical', '.-O']
['The-O', 'patient-O', 'also-O', 'received-O', 'simvastatin-B-Chemical', '.-O']
['One-O', 'month-O', 'after-O', 'starting-O', 'the-O', 'antiviral-O', 'therapy-O', ',-O', 'the-O', 'patient-O', 'was-O', 'admitted-O', 'to-O', 'the-O', 'hospital-O', 'because-O', 'he-O', 'developed-O', 'rhabdomyolysis-B-Disease', '.-O']
['At-O', 'admission-O', 'simvastatin-B-Chemical', 'and-O', 'all-O', 'antiviral-O', 'drugs-O', 'were-O', 'discontinued-O', 'because-O', 'toxicity-O', 'due-O', 'to-O', 'a-O', 'drug-O', ',-O', 'drug-O', 'interaction-O', 'was-O', 'suspected-O', '.-O']
['The-O', 'creatine-B-Chemical', 'kinase-O', 'peaked-O', 'at-O', '62-O', ',-O', '246-O', 'IU-O', '/-O', 'L-O', 'and-O', 'the-O', 'patient-O', 'was-O', 'treated-O', 'with-O', 'intravenous-O', 'normal-O', 'saline-O', '.-O']
['The-O', 'patient-O', 'x-O', 's-O', 'renal-O', 'function-O', 'remained-O', 'unaffected-O', '.-O']
['Fourteen-O', 'days-O', 'after-O', 'hospitalization-O', ',-O', 'creatine-B-Chemical', 'kinase-O', 'level-O', 'had-O', 'returned-O', 'to-O', '230-O', 'IU-O', '/-O', 'L-O', 'and-O', 'the-O', 'patient-O', 'was-O', 'discharged-O', '.-O']
['Telaprevir-B-Chemical', 'was-O', 'considered-O', 'the-O', 'probable-O', 'causative-O', 'agent-O', 'of-O', 'an-O', 'interaction-O', 'with-O', 'simvastatin-B-Chemical', 'according-O', 'to-O', 'the-O', 'Drug-O', 'Interaction-O', 'Probability-O', 'Scale-O', '.-O']
['The-O', 'interaction-O', 'is-O', 'due-O', 'to-O', 'inhibition-O', 'of-O', 'CYP3A4-O', ',-O', 'mediated-O', 'simvastatin-B-Chemical', 'clearance-O', '.-O']
['Simvastatin-B-Chemical', 'plasma-O', 'concentration-O', 'increased-O', '30-O', 'times-O', 'in-O', 'this-O', 'patient-O', 'and-O', 'statin-B-Chemical', 'induced-O', 'muscle-O', 'toxicity-O', 'is-O', 'related-O', 'to-O', 'the-O', 'concentration-O', 'of-O', 'the-O', 'statin-B-Chemical', 'in-O', 'blood-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'with-O', 'this-O', 'case-O', 'we-O', 'illustrate-O', 'that-O', 'telaprevir-B-Chemical', 'as-O', 'well-O', 'as-O', 'statins-B-Chemical']
['Combination-O', 'of-O', 'bortezomib-B-Chemical', ',-O', 'thalidomide-B-Chemical', ',-O', 'and-O', 'dexamethasone-B-Chemical', '(-O', 'VTD-O', ')-O', 'as-O', 'a-O', 'consolidation-O', 'therapy-O', 'after-O', 'autologous-O', 'stem-O', 'cell-O', 'transplantation-O', 'for-O', 'symptomatic-O', 'multiple-O', 'myeloma-B-Disease', 'in-O', 'Japanese-O', 'patients-O', '.-O']
['Consolidation-O', 'therapy-O', 'for-O', 'patients-O', 'with-O', 'multiple-O', 'myeloma-B-Disease', '(-O', 'MM-B-Disease', ')-O', 'has-O', 'been-O', 'widely-O', 'adopted-O', 'to-O', 'improve-O', 'treatment-O', 'response-O', 'following-O', 'autologous-O', 'stem-O', 'cell-O', 'transplantation-O', '.-O']
['In-O', 'this-O', 'study-O', ',-O', 'we-O', 'retrospectively-O', 'analyzed-O', 'the-O', 'safety-O', 'and-O', 'efficacy-O', 'of-O', 'combination-O', 'regimen-O', 'of-O', 'bortezomib-B-Chemical', ',-O', 'thalidomide-B-Chemical', ',-O', 'and-O', 'dexamethasone-B-Chemical', '(-O', 'VTD-B-Chemical', ')-O', 'as-O', 'consolidation-O', 'therapy-O', 'in-O', '24-O', 'Japanese-O', 'patients-O', 'with-O', 'newly-O', 'diagnosed-O', 'MM-B-Disease', '.-O']
['VTD-O', 'consisted-O', 'of-O', 'bortezomib-B-Chemical', 'at-O', 'a-O', 'dose-O', 'of-O', '1-O', '.-O']
['3-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'and-O', 'dexamethasone-B-Chemical', 'at-O', 'a-O', 'dose-O', 'of-O', '40-O', 'mg-O', '/-O', 'day-O', 'on-O', 'days-O', '1-O', ',-O', '8-O', ',-O', '15-O', ',-O', 'and-O', '22-O', 'of-O', 'a-O', '35-O', ',-O', 'day-O', 'cycle-O', ',-O', 'with-O', 'daily-O', 'oral-O', 'thalidomide-B-Chemical', 'at-O', 'a-O', 'dose-O', 'of-O', '100-O', 'mg-O', '/-O', 'day-O', '.-O']
['Grade-O', '3-O', ',-O', '4-O', 'neutropenia-B-Disease', 'and-O', 'thrombocytopenia-B-Disease', 'were-O', 'documented-O', 'in-O', 'four-O', 'and-O', 'three-O', 'patients-O', '(-O', '17-O', 'and-O', '13-O', ')-O', 'respectively-O', ',-O', 'but-O', 'drug-O', 'dose-O', 'reduction-O', 'due-O', 'to-O', 'cytopenia-B-Disease', 'was-O', 'not-O', 'required-O', 'in-O', 'any-O', 'case-O', '.-O']
['Peripheral-B-Disease', 'neuropathy-I-Disease', 'was-O', 'common-O', '(-O', '63-O', ')-O', 'but-O', 'severe-O', 'grade-O', '3-O', ',-O', '4-O', 'peripheral-B-Disease', 'neuropathy-I-Disease']
['Conversion-O', 'to-O', 'sirolimus-B-Chemical', 'ameliorates-O', 'cyclosporine-B-Chemical', ',-O', 'induced-O', 'nephropathy-B-Disease', 'in-O', 'the-O', 'rat-O', ':-O', 'focus-O', 'on-O', 'serum-O', ',-O', 'urine-O', ',-O', 'gene-O', ',-O', 'and-O', 'protein-O', 'renal-O', 'expression-O', 'biomarkers-O', '.-O']
['Protocols-O', 'of-O', 'conversion-O', 'from-O', 'cyclosporin-B-Chemical', 'A-I-Chemical', '(-O', 'CsA-B-Chemical', ')-O', 'to-O', 'sirolimus-B-Chemical', '(-O', 'SRL-B-Chemical', ')-O', 'have-O', 'been-O', 'widely-O', 'used-O', 'in-O', 'immunotherapy-O', 'after-O', 'transplantation-O', 'to-O', 'prevent-O', 'CsA-B-Chemical', ',-O', 'induced-O', 'nephropathy-B-Disease', ',-O', 'but-O', 'the-O', 'molecular-O', 'mechanisms-O', 'underlying-O', 'these-O', 'protocols-O', 'remain-O', 'nuclear-O', '.-O']
['This-O', 'study-O', 'aimed-O', 'to-O', 'identify-O', 'the-O', 'molecular-O', 'pathways-O', 'and-O', 'putative-O', 'biomarkers-O', 'of-O', 'CsA-B-Chemical', ',-O', 'to-O', ',-O', 'SRL-B-Chemical', 'conversion-O', 'in-O', 'a-O', 'rat-O', 'model-O', '.-O']
['Four-O', 'animal-O', 'groups-O', '(-O', 'n-O', '=-O', '6-O', ')-O', 'were-O', 'tested-O', 'during-O', '9-O', 'weeks-O', ':-O', 'control-O', ',-O', 'CsA-B-Chemical', ',-O', 'SRL-B-Chemical', ',-O', 'and-O', 'conversion-O', '(-O', 'CsA-B-Chemical', 'for-O', '3-O', 'weeks-O', 'followed-O', 'by-O', 'SRL-B-Chemical', 'for-O', '6-O', 'weeks-O', ').-O', 'Classical-O', 'and-O', 'emergent-O', 'serum-O', ',-O', 'urinary-O', ',-O', 'and-O', 'kidney-O', 'tissue-O', '(-O', 'gene-O', 'and-O', 'protein-O', 'expression-O', ')-O', 'markers-O', 'were-O', 'assessed-O', '.-O']
['Renal-O', 'lesions-O', 'were-O', 'analyzed-O', 'in-O', 'hematoxylin-B-Chemical', 'and-O', 'eosin-B-Chemical', ',-O', 'periodic-O', 'acid-B-Chemical', ',-O', 'Schiff-B-Chemical', ',-O', 'and-O', 'Masson-O', 'x-O', 's-O', 'trichrome-O', 'stains-O', '.-O']
['SRL-B-Chemical', ',-O', 'treated-O', 'rats-O', 'presented-O', 'proteinuria-B-Disease', 'and-O', 'NGAL-B-Chemical', '(-O', 'serum-O', 'and-O', 'urinary-O', ')-O', 'as-O', 'the-O', 'best-O', 'markers-O', 'of-O', 'renal-O', 'impairment-O', '.-O']
['Short-O', 'CsA-B-Chemical', 'treatment-O', 'presented-O', 'slight-O', 'or-O', 'even-O', 'absent-O', 'kidney-O', 'lesions-O', 'and-O', 'TGF-B-Chemical', ',-O', 'b-O', ',-O', 'NF-O', ',-O', 'kb-O', ',-O', 'mTOR-B-Chemical', ',-O', 'PCNA-B-Chemical', ',-O', 'TP53-B-Chemical', ',-O', 'KIM-B-Chemical', ',-O', '1-O', ',-O', 'and-O', 'CTGF-B-Chemical', 'as-O', 'relevant-O', 'gene-O', 'and-O', 'protein-O', 'changes-O', '.-O']
['Prolonged-O', 'CsA-B-Chemical', 'exposure-O', 'aggravated-O', 'renal-B-Disease', 'damage-I-Disease', ',-O', 'without-O', 'clear-O', 'changes-O', 'on-O', 'the-O', 'traditional-O', 'markers-O', ',-O', 'but-O', 'with-O', 'changes-O', 'in-O', 'serums-O', 'TGF-B-Chemical', ',-O', 'b-O', 'and-O', 'IL-O', ',-O', '7-O', ',-O', 'TBARs-O', 'clearance-O', ',-O', 'and-O', 'kidney-O', 'TGF-B-Chemical', ',-O', 'b-O', 'and-O', 'mTOR-O', '.-O']
['Conversion-O', 'to-O', 'SRL-B-Chemical', 'prevented-O', 'CsA-B-Chemical', ',-O', 'induced-O', 'renal-B-Disease', 'damage-O', 'evolution-O', '(-O', 'absent-O', '/-O', 'mild-O', 'grade-O', 'lesions-O', ')-O', 'while-O', 'NGAL-B-Chemical', '(-O', 'serum-O', 'versus-O', 'urine-O', ')-O', 'seems-O', 'to-O', 'be-O', 'a-O', 'feasible-O', 'biomarker-O', 'of-O', 'CsA-B-Chemical', 'replacement-O', 'to-O', 'SRL-B-Chemical']
['Kinin-O', 'B2-O', 'receptor-O', 'deletion-O', 'and-O', 'blockage-O', 'ameliorates-O', 'cisplatin-B-Chemical', ',-O', 'induced-O', 'acute-O', 'renal-B-Disease', 'injury-I-Disease', '.-O']
['Cisplatin-B-Chemical', 'treatment-O', 'has-O', 'been-O', 'adopted-O', 'in-O', 'some-O', 'chemotherapies-O', ';-O', 'however-O', ',-O', 'this-O', 'drug-O', 'can-O', 'induce-O', 'acute-B-Disease', 'kidney-O', 'injury-I-Disease', 'due-O', 'its-O', 'ability-O', 'to-O', 'negatively-O', 'affect-O', 'renal-O', 'function-O', ',-O', 'augment-O', 'serum-O', 'levels-O', 'of-O', 'creatinine-B-Chemical', 'and-O', 'urea-B-Chemical', ',-O', 'increase-O', 'the-O', 'acute-B-Disease', 'tubular-I-Disease', 'necrosis-I-Disease', 'score-O', 'and-O', 'up-O', ',-O', 'regulate-O', 'cytokines-O', '(-O', 'e-O', '.-O']
['g-O', '.-O', 'IL-O', ',-O', '1b-O', 'and-O', 'TNF-O', ',-O', 'a-O', ')-O', 'The-O', 'kinin-O', 'B2-O', 'receptor-O', 'has-O', 'been-O', 'associated-O', 'with-O', 'the-O', 'inflammation-O', 'process-O', ',-O', 'as-O', 'well-O', 'as-O', 'the-O', 'regulation-O', 'of-O', 'cytokine-O', 'expression-O', ',-O', 'and-O', 'its-O', 'deletion-O', 'resulted-O', 'in-O', 'an-O', 'improvement-O', 'in-O', 'the-O', 'diabetic-O', 'nephropathy-B-Disease', 'status-O', '.-O']
['To-O', 'examine-O', 'the-O', 'role-O', 'of-O', 'the-O', 'kinin-B-Chemical', 'B2-O', 'receptor-O', 'in-O', 'cisplatin-B-Chemical', ',-O', 'induced-O', 'acute-O', 'kidney-O', 'injury-B-Disease', ',-O', 'kinin-B-Chemical', 'B2-O', 'receptor-O', 'knockout-O', 'mice-O', 'were-O', 'challenged-O', 'with-O', 'cisplatin-B-Chemical', '.-O']
['Additionally-O', ',-O', 'WT-O', 'mice-O', 'were-O', 'treated-O', 'with-O', 'a-O', 'B2-O', 'receptor-O', 'antagonist-O', 'after-O', 'cisplatin-B-Chemical', 'administration-O', '.-O']
['B2-O', 'receptor-O', ',-O', 'deficient-O', 'mice-O', 'were-O', 'less-O', 'sensitive-O', 'to-O', 'this-O', 'drug-O', 'than-O', 'the-O', 'WT-O', 'mice-O', ',-O', 'as-O', 'shown-O', 'by-O', 'reduced-O', 'weight-O', 'loss-O', ',-O', 'better-O', 'preservation-O', 'of-O', 'kidney-O', 'function-O', ',-O', 'down-O', 'regulation-O', 'of-O', 'inflammatory-O', 'cytokines-O', 'and-O', 'less-O', 'acute-O', 'tubular-O', 'necrosis-B-Disease', '.-O']
['Moreover-O', ',-O', 'treatment-O', 'with-O', 'the-O', 'kinin-B-Chemical', 'B2-O', 'receptor-O', 'antagonist-O', 'effectively-O', 'reduced-O', 'the-O', 'levels-O', 'of-O', 'serum-O', 'creatinine-B-Chemical', 'and-O', 'blood-O', 'urea-B-Chemical', 'after-O', 'cisplatin-B-Chemical', 'administration-O', '.-O']
['Thus-O', ',-O', 'our-O', 'data-O', 'suggest-O', 'that-O', 'the-O', 'kinin-B-Chemical', 'B2-O', 'receptor-O', 'is-O', 'involved-O', 'in-O', 'cisplatin-B-Chemical', ',-O', 'induced-O', 'acute-O', 'kidney-B-Disease', 'injury-I-Disease', 'by-O', 'mediating-O', 'the-O', 'necrotic-O', 'process-O', 'and-O', 'the-O', 'expression-O', 'of-O', 'inflammatory-O', 'cytokines-O', ',-O', 'thus-O', 'resulting-O', 'in-O', 'declined-O', 'renal-O', 'function-O', '.-O']
['These-O', 'results-O', 'highlight-O', 'the-O', 'kinin-B-Chemical', 'B2-O', 'receptor-O', 'antagonist-O', 'treatment-O', 'in-O', 'amelioration-O', 'of-O', 'nephrotoxicity-B-Disease', 'induced-O', 'by-O', 'cisplatin-B-Chemical']
['Safety-O', 'and-O', 'efficacy-O', 'of-O', 'fluocinolone-B-Chemical', 'acetonide-I-Chemical', 'intravitreal-O', 'implant-O', '(-O', '0-O', '.-O']
['59-O', 'mg-O', ')-O', 'in-O', 'birdshot-O', 'retinochoroidopathy-B-Disease', '.-O']
['PURPOSE-O', ':-O', 'To-O', 'report-O', 'the-O', 'treatment-O', 'outcomes-O', 'of-O', 'the-O', 'fluocinolone-B-Chemical', 'acetonide-B-Chemical', 'intravitreal-O', 'implant-O', '(-O', '0-O', '.-O']
['59-O', 'mg-O', ')-O', 'in-O', 'patients-O', 'with-O', 'birdshot-B-Disease', 'retinochoroidopathy-I-Disease', 'whose-O', 'disease-O', 'is-O', 'refractory-O', 'or-O', 'intolerant-O', 'to-O', 'conventional-O', 'immunomodulatory-O', 'therapy-O', '.-O']
['METHODS-O', ':-O', 'A-O', 'retrospective-O', 'case-O', 'series-O', 'involving-O', '11-O', 'birdshot-O', 'retinochoroidopathy-B-Disease', 'patients-O', '(-O', '11-O', 'eyes-O', ').-O', 'Eleven-O', 'patients-O', '(-O', '11-O', 'eyes-O', ')-O', 'underwent-O', 'surgery-O', 'for-O', 'fluocinolone-B-Chemical', 'acetonide-B-Chemical', 'implant-O', '(-O', '0-O', '.-O']
['59-O', 'mg-O', ').-O', 'Treatment-O', 'outcomes-O', 'of-O', 'interest-O', 'were-O', 'noted-O', 'at-O', 'baseline-O', ',-O', 'before-O', 'fluocinolone-B-Chemical', 'acetonide-B-Chemical', 'implant-O', ',-O', 'and-O', 'then-O', 'at-O', '6-O', 'months-O', ',-O', '1-O', 'year-O', ',-O', '2-O', 'years-O', ',-O', '3-O', 'years-O', ',-O', 'and-O', 'beyond-O', '3-O', 'years-O', '.-O']
['Disease-B-Disease', 'activity-O', 'markers-O', ',-O', 'including-O', 'signs-O', 'of-O', 'ocular-O', 'inflammation-B-Disease', ',-O', 'evidence-O', 'of-O', 'retinal-O', 'vasculitis-B-Disease', ',-O', 'Swedish-O', 'interactive-O', 'threshold-O', 'algorithm-O', ',-O', 'short-O', 'wavelength-O', 'automated-O', 'perimetry-O', 'Humphrey-O', 'visual-O', 'field-O', 'analysis-O', ',-O', 'electroretinographic-O', 'parameters-O', ',-O', 'and-O', 'optical-O', 'coherence-O', 'tomography-O', 'were-O', 'recorded-O', '.-O']
['Data-O', 'on-O', 'occurrence-O', 'of-O', 'cataract-B-Disease', 'and-O', 'raised-O', 'intraocular-O', 'pressure-O', 'were-O', 'collected-O', 'in-O', 'all-O', 'eyes-O', '.-O']
['RESULTS-O', ':-O', 'Intraocular-O', 'inflammation-B-Disease', 'was-O', 'present-O', 'in-O', '54-O', '.-O']
['5-O', ',-O', '9-O', '.-O']
['9-O', ',-O', '11-O', '.-O']
['1-O', ',-O', 'and-O', '0-O', '%-O', 'of-O', 'patients-O', 'at-O', 'baseline-O', ',-O', '6-O', 'months-O', ',-O', '1-O', 'year-O', ',-O', '2-O', 'years-O', ',-O', '3-O', 'years-O', ',-O', 'and-O', 'beyond-O', '3-O', 'years-O', 'after-O', 'receiving-O', 'the-O', 'implant-O', ',-O', 'respectively-O', '.-O']
['Active-O', 'vasculitis-B-Disease', 'was-O', 'noted-O', 'in-O', '36-O', '.-O']
['3-O', '%-O', 'patients-O', 'at-O', 'baseline-O', 'and-O', '0-O', '%-O', 'at-O', '3-O', 'years-O', 'of-O', 'follow-O', ',-O', 'up-O', '.-O']
['More-O', 'than-O', '20-O', '(-O', '47-O', '.-O']
['61-O', ',-O', '67-O', '.-O']
['2-O', ')-O', 'reduction-O', 'in-O', 'central-O', 'retinal-B-Disease', 'thickness-O', 'was-O', 'noted-O', 'in-O', 'all-O', 'patients-O', 'with-O', 'cystoid-O', 'macular-B-Disease', 'edema-B-Disease', 'at-O', '6-O', 'months-O', ',-O', '1-O', 'year-O', ',-O', '2-O', 'years-O', ',-O', 'and-O', '3-O', 'years-O', 'postimplant-O', '.-O']
['At-O', 'baseline-O', ',-O', '54-O', '.-O']
['5-O', '%-O', 'patients-O', 'were-O', 'on-O', 'immunomodulatory-O', 'agents-O', '.-O']
['This-O', 'percentage-O', 'decreased-O', 'to-O', '45-O', '.-O']
['45-O', ',-O', '44-O', '.-O']
['4-O', ',-O', 'and-O', '14-O', '.-O']
['28-O', '%-O', 'at-O', '1-O', 'year-O', ',-O', '2-O', 'years-O', ',-O', 'and-O', '3-O', 'years-O', 'postimplant-O', ',-O', 'respectively-O', '.-O']
['Adverse-O', 'events-O', 'included-O', 'increased-O', 'intraocular-O', 'pressure-B-Disease', '(-O', '54-O', '.-O']
['5-O', ')-O', 'and-O', 'cataract-B-Disease', 'formation-O', '(-O', '100-O', ').-O', 'CONCLUSION-O', ':-O', 'The-O', 'data-O', 'suggest-O', 'that-O', 'fluocinolone-B-Chemical', 'acetonide-B-Chemical', 'implant-O', '(-O', '0-O', '.-O']
['59-O', 'mg-O', ')-O', 'helps-O', 'to-O', 'control-O', 'inflammation-B-Disease', 'in-O', 'otherwise-O', 'treatment-O', ',-O', 'refractory-O', 'cases-O', 'of-O', 'birdshot-B-Disease', 'retinochoroidopathy-B-Disease', '.-O']
['It-O', 'is-O', 'associated-O', 'with-O', 'significant-O', 'side-O', 'effects-O', 'of-O', 'cataract-B-Disease', 'and-O', 'ocular-B-Disease', 'hypertension-B-Disease']
['Optimal-O', 'precurarizing-O', 'dose-O', 'of-O', 'rocuronium-B-Chemical', 'to-O', 'decrease-O', 'fasciculation-B-Disease', 'and-O', 'myalgia-B-Disease', 'following-O', 'succinylcholine-B-Chemical', 'administration-O', '.-O']
['BACKGROUND-O', ':-O', 'Succinylcholine-B-Chemical', 'commonly-O', 'produces-O', 'frequent-O', 'adverse-O', 'effects-O', ',-O', 'including-O', 'muscle-O', 'fasciculation-B-Disease', 'and-O', 'myalgia-B-Disease', '.-O']
['The-O', 'current-O', 'study-O', 'identified-O', 'the-O', 'optimal-O', 'dose-O', 'of-O', 'rocuronium-B-Chemical', 'to-O', 'prevent-O', 'succinylcholine-B-Chemical', ',-O', 'induced-O', 'fasciculation-B-Disease', 'and-O', 'myalgia-B-Disease', 'and-O', 'evaluated-O', 'the-O', 'influence-O', 'of-O', 'rocuronium-B-Chemical', 'on-O', 'the-O', 'speed-O', 'of-O', 'onset-O', 'produced-O', 'by-O', 'succinylcholine-B-Chemical', '.-O']
['METHODS-O', ':-O', 'This-O', 'randomized-O', ',-O', 'double-O', ',-O', 'blinded-O', 'study-O', 'was-O', 'conducted-O', 'in-O', '100-O', 'patients-O', 'randomly-O', 'allocated-O', 'into-O', 'five-O', 'groups-O', 'of-O', '20-O', 'patients-O', 'each-O', '.-O']
['Patients-O', 'were-O', 'randomized-O', 'to-O', 'receive-O', '0-O', '.-O']
['02-O', ',-O', '0-O', '.-O']
['03-O', ',-O', '0-O', '.-O']
['04-O', ',-O', '0-O', '.-O', '05-O']
['05-O', 'and-O', '0-O', '.-O']
['06-O', 'mg-O', '/-O', 'kg-O', 'rocuronium-B-Chemical', 'as-O', 'a-O', 'precurarizing-O', 'dose-O', '.-O']
['Neuromuscular-O', 'monitoring-O', 'after-O', 'each-O', 'precurarizing-O', 'dose-O', 'was-O', 'recorded-O', 'from-O', 'the-O', 'adductor-O', 'pollicis-O', 'muscle-O', 'using-O', 'acceleromyography-O', 'with-O', 'train-O', ',-O', 'of-O', ',-O', 'four-O', 'stimulation-O', 'of-O', 'the-O', 'ulnar-O', 'nerve-O', '.-O']
['All-O', 'patients-O', 'received-O', 'succinylcholine-B-Chemical', '1-O', '.-O']
['5-O', 'mg-O', '/-O', 'kg-O', 'at-O', '2-O', 'minutes-O', 'after-O', 'the-O', 'precurarization-O', ',-O', 'and-O', 'were-O', 'assessed-O', 'the-O', 'incidence-O', 'and-O', 'severity-O', 'of-O', 'fasciculations-B-Disease', ',-O', 'while-O', 'myalgia-B-Disease', 'was-O', 'assessed-O', 'at-O', '24-O', 'hours-O', 'after-O', 'surgery-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'incidence-O', 'and-O', 'severity-O', 'of-O', 'visible-O', 'muscle-B-Disease', 'fasciculation-B-Disease', 'was-O', 'significantly-O', 'less-O', 'with-O', 'increasing-O', 'the-O', 'amount-O', 'of-O', 'precurarizing-O', 'dose-O', 'of-O', 'rocuronium-B-Chemical', '(-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'Those-O', 'of-O', 'myalgia-B-Disease', 'tend-O', 'to-O', 'decrease-O', 'according-O', 'to-O', 'increasing-O', 'the-O', 'amount-O', 'of-O', 'precurarizing-O', 'dose-O', 'of-O', 'rocuronium-B-Chemical', ',-O', 'but-O', 'there-O', 'was-O', 'no-O', 'significance-O', '(-O', 'P-O', '=-O', '0-O', '.-O']
['072-O', ').-O', 'The-O', 'onset-O', 'time-O', 'of-O', 'succinylcholine-B-Chemical', 'was-O', 'significantly-O', 'longer-O', 'with-O', 'increasing-O', 'the-O', 'amount-O', 'of-O', 'precurarizing-O', 'dose-O', 'of-O', 'rocuronium-B-Chemical', '(-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'CONCLUSIONS-O', ':-O', 'Precurarization-O', 'with-O', '0-O', '.-O']
['04-O', 'mg-O', '/-O', 'kg-O', 'rocuronium-B-Chemical', 'was-O', 'the-O', 'optimal-O', 'dose-O', 'considering-O', 'the-O', 'reduction-O', 'in-O', 'the-O', 'incidence-O', 'and-O', 'severity-O', 'of-O', 'fasciculation-B-Disease', 'and-O', 'myalgia-B-Disease']
['Absence-O', 'of-O', 'PKC-O', ',-O', 'alpha-O', 'attenuates-O', 'lithium-B-Chemical', ',-O', 'induced-O', 'nephrogenic-O', 'diabetes-B-Disease', 'insipidus-I-Disease', '.-O']
['Lithium-B-Chemical', ',-O', 'an-O', 'effective-O', 'antipsychotic-O', ',-O', 'induces-O', 'nephrogenic-O', 'diabetes-B-Disease', 'insipidus-I-Disease', '(-O', 'NDI-O', ')-O', 'in-O', '40-O', '%-O', 'of-O', 'patients-O', '.-O']
['The-O', 'decreased-O', 'capacity-O', 'to-O', 'concentrate-O', 'urine-O', 'is-O', 'likely-O', 'due-O', 'to-O', 'lithium-B-Chemical', 'acutely-O', 'disrupting-O', 'the-O', 'cAMP-O', 'pathway-O', 'and-O', 'chronically-O', 'reducing-O', 'urea-B-Chemical', 'transporter-O', '(-O', 'UT-O', ',-O', 'A1-O', ')-O', 'and-O', 'water-O', 'channel-O', '(-O', 'AQP2-O', ')-O', 'expression-O', 'in-O', 'the-O', 'inner-O', 'medulla-O', '.-O']
['Targeting-O', 'an-O', 'alternative-O', 'signaling-O', 'pathway-O', ',-O', 'such-O', 'as-O', 'PKC-O', ',-O', 'mediated-O', 'signaling-O', ',-O', 'may-O', 'be-O', 'an-O', 'effective-O', 'method-O', 'of-O', 'treating-O', 'lithium-B-Chemical', ',-O', 'induced-O', 'polyuria-B-Disease', '.-O']
['PKC-O', ',-O', 'alpha-O', 'null-O', 'mice-O', '(-O', 'PKCa-O', 'KO-O', ')-O', 'and-O', 'strain-O', ',-O', 'matched-O', 'wild-O', '--O', 'type-O', '(-O', 'WT-O', ')-O', 'controls-O', 'were-O', 'treated-O', 'with-O', 'lithium-B-Chemical', 'for-O', '0-O', ',-O', '3-O', 'or-O', '5-O', 'days-O', '.-O']
['WT-O', 'mice-O', 'had-O', 'increased-O', 'urine-O', 'output-O', 'and-O', 'lowered-O', 'urine-O', 'osmolality-O', 'after-O', '3-O', 'and-O', '5-O', 'days-O', 'of-O', 'treatment-O', 'whereas-O', 'PKCa-O', 'KO-O', 'mice-O', 'had-O', 'no-O', 'change-O', 'in-O', 'urine-O', 'output-O', 'or-O', 'concentration-O', '.-O']
['Western-O', 'blot-O', 'analysis-O', 'revealed-O', 'that-O', 'AQP2-O', 'expression-O', 'in-O', 'medullary-O', 'tissues-O', 'was-O', 'lowered-O', 'after-O', '3-O', 'and-O', '5-O', 'days-O', 'in-O', 'WT-O', 'mice-O', ';-O', 'however-O', ',-O', 'AQP2-O', 'was-O', 'unchanged-O', 'in-O', 'PKCa-O', 'KO-O', '.-O']
['Similar-O', 'results-O', 'were-O', 'observed-O', 'with-O', 'UT-O', ',-O', 'A1-O', 'expression-O', '.-O']
['Animals-O', 'were-O', 'also-O', 'treated-O', 'with-O', 'lithium-B-Chemical', 'for-O', '6-O', 'weeks-O', '.-O']
['Lithium-B-Chemical', ',-O', 'treated-O', 'WT-O', 'mice-O', 'had-O', '19-O', ',', 'fold-O', 'increased-O', 'urine-O', 'output-O', 'whereas-O', 'treated-O', 'PKCa-B-Chemical', 'KO-O', 'animals-O', 'had-O', 'a-O', '4-O', ',', 'fold-O', 'increase-O', 'in-O', 'output-O', '.-O']
['AQP2-O', 'and-O', 'UT-O', ',-O', 'A1-O', 'expression-O', 'was-O', 'lowered-O', 'in-O', '6-O', 'week-O', 'lithium-B-Chemical', ',-O', 'treated-O', 'WT-O', 'animals-O', 'whereas-O', 'in-O', 'treated-O', 'PKCa-O', 'KO-O', 'mice-O', ',-O', 'AQP2-O', 'was-O', 'only-O', 'reduced-O', 'by-O', '2-O', ',-O', 'fold-O', 'and-O', 'UT-O', ',-O', 'A1-O', 'expression-O', 'was-O', 'unaffected-O', '.-O']
['Urinary-O', 'sodium-B-Chemical', ',-O', 'potassium-B-Chemical', 'and-O', 'calcium-B-Chemical', 'were-O', 'elevated-O', 'in-O', 'lithium-B-Chemical', ',-O', 'fed-O', 'WT-O', 'but-O', 'not-O', 'in-O', 'lithium-B-Chemical', ',-O', 'fed-O', 'PKCa-O', 'KO-O', 'mice-O', '.-O']
['Our-O', 'data-O', 'show-O', 'that-O', 'ablation-O', 'of-O', 'PKCa-B-Chemical', 'preserves-O', 'AQP2-B-Chemical', 'and-O', 'UT-O', 'A1-B-Chemical', 'protein-O', 'expression-O', 'and-O', 'localization-O', 'in-O', 'lithium-B-Chemical', ',-O', 'induced-O', 'NDI-B-Disease', ',-O', 'and-O', 'prevents-O', 'the-O', 'development-O', 'of-O', 'the-O', 'severe-O', 'polyuria-B-Disease', 'associated-O', 'with-O', 'lithium-B-Chemical']
['Is-O', 'Dysguesia-B-Disease', 'Going-O', 'to-O', 'be-O', 'a-O', 'Rare-O', 'or-O', 'a-O', 'Common-O', 'Side-O', ',-O', 'effect-O', 'of-O', 'Amlodipine-B-Chemical', '?-O', 'A-O', 'very-O', 'rare-O', 'side-O', ',-O', 'effect-O', 'of-O', 'amlodipine-B-Chemical', 'is-O', 'dysguesia-B-Disease', '.-O']
['A-O', 'review-O', 'of-O', 'the-O', 'literature-O', 'produced-O', 'only-O', 'one-O', 'case-O', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'about-O', 'a-O', 'female-O', 'with-O', 'essential-O', 'hypertension-B-Disease', 'on-O', 'drug-O', 'treatment-O', 'with-O', 'amlodipine-B-Chemical', 'developed-O', 'loss-O', 'of-O', 'taste-O', 'sensation-O', '.-O']
['Condition-O', 'moderately-O', 'improved-O', 'on-O', 'stoppage-O', 'of-O', 'the-O', 'drug-O', 'for-O', '25-O', 'days-O', '.-O']
['We-O', 'conclude-O', 'that-O', 'amlodipine-B-Chemical', 'can-O', 'cause-O', 'dysguesia-B-Disease', '.-O']
['Here-O', ',-O', 'we-O', 'describe-O', 'the-O', 'clinical-O', 'presentation-O', 'and-O', 'review-O', 'the-O', 'relevant-O', 'literature-O', 'on-O', 'amlodipine-B-Chemical', 'and-O', 'dysguesia-B-Disease']
['Rhabdomyolysis-B-Disease', 'in-O', 'association-O', 'with-O', 'simvastatin-B-Chemical', 'and-O', 'dosage-O', 'increment-O', 'in-O', 'clarithromycin-B-Chemical', '.-O']
['Clarithromycin-B-Chemical', 'is-O', 'the-O', 'most-O', 'documented-O', 'cytochrome-O', 'P450-O', '3A4-O', '(-O', 'CYP3A4-O', ')-O', 'inhibitor-O', 'to-O', 'cause-O', 'an-O', 'adverse-O', 'interaction-O', 'with-O', 'simvastatin-B-Chemical', '.-O']
['This-O', 'particular-O', 'case-O', 'is-O', 'of-O', 'interest-O', 'as-O', 'rhabdomyolysis-B-Disease', 'only-O', 'occurred-O', 'after-O', 'an-O', 'increase-O', 'in-O', 'the-O', 'dose-O', 'of-O', 'clarithromycin-B-Chemical', '.-O']
['The-O', 'patient-O', 'developed-O', 'raised-O', 'cardiac-O', 'biomarkers-O', 'without-O', 'any-O', 'obvious-O', 'cardiac-O', 'issues-O', ',-O', 'a-O', 'phenomenon-O', 'that-O', 'has-O', 'been-O', 'linked-O', 'to-O', 'rhabdomyolysis-B-Disease', 'previously-O', '.-O']
['To-O', 'date-O', ',-O', 'there-O', 'has-O', 'been-O', 'no-O', 'reported-O', 'effect-O', 'of-O', 'rhabdomyolysis-B-Disease', 'on-O', 'the-O', 'structure-O', 'and-O', 'function-O', 'of-O', 'cardiac-O', 'muscle-O', '.-O']
['Clinicians-O', 'need-O', 'to-O', 'be-O', 'aware-O', 'of-O', 'prescribing-O', 'concomitant-O', 'medications-O', 'that-O', 'increase-O', 'the-O', 'risk-O', 'of-O', 'myopathy-B-Disease', 'or-O', 'inhibit-O', 'the-O', 'CYP3A4-O', 'enzyme-O', '.-O']
['Our-O', 'case-O', 'suggests-O', 'that-O', 'troponin-O', 'elevation-O', 'could-O', 'be-O', 'associated-O', 'with-O', 'statin-B-Chemical', 'induced-O', 'rhabdomyolysis-B-Disease']
['Characterization-O', 'of-O', 'a-O', 'novel-O', 'BCHE-O', 'x-O', 'silent-O', 'x-O', 'allele-O', ':-O', 'point-O', 'mutation-O', '(-O', 'p-O', '.-O']
['Val204Asp-O', ')-O', 'causes-O', 'loss-O', 'of-O', 'activity-O', 'and-O', 'prolonged-O', 'apnea-B-Disease', 'with-O', 'suxamethonium-B-Chemical', '.-O']
['Butyrylcholinesterase-O', 'deficiency-O', 'is-O', 'characterized-O', 'by-O', 'prolonged-O', 'apnea-B-Disease', 'after-O', 'the-O', 'use-O', 'of-O', 'muscle-O', 'relaxants-O', '(-O', 'suxamethonium-B-Chemical', 'or-O', 'mivacurium-B-Chemical', ')-O', 'in-O', 'patients-O', 'who-O', 'have-O', 'mutations-O', 'in-O', 'the-O', 'BCHE-O', 'gene-O', '.-O']
['Here-O', ',-O', 'we-O', 'report-O', 'a-O', 'case-O', 'of-O', 'prolonged-O', 'neuromuscular-O', 'block-O', 'after-O', 'administration-O', 'of-O', 'suxamethonium-B-Chemical', 'leading-O', 'to-O', 'the-O', 'discovery-O', 'of-O', 'a-O', 'novel-O', 'BCHE-O', 'variant-O', '(-O', 'c-O', '.-O']
['695T-O', '>-O', 'A-O', ',-O', 'p-O', '.-O']
['Val204Asp-O', ').-O', 'Inhibition-O', 'studies-O', ',-O', 'kinetic-O', 'analysis-O', 'and-O', 'molecular-O', 'dynamics-O', 'were-O', 'undertaken-O', 'to-O', 'understand-O', 'how-O', 'this-O', 'mutation-O', 'disrupts-O', 'the-O', 'catalytic-O', 'triad-O', 'and-O', 'determines-O', 'a-O', 'x-O', 'silent-O', 'x-O', 'phenotype-O', '.-O']
['Low-O', 'activity-O', 'of-O', 'patient-O', 'plasma-O', 'butyrylcholinesterase-O', 'with-O', 'butyrylthiocholine-B-Chemical', '(-O', 'BTC-O', ')-O', 'and-O', 'benzoylcholine-B-Chemical', ',-O', 'and-O', 'values-O', 'of-O', 'dibucaine-B-Chemical', 'and-O', 'fluoride-B-Chemical', 'numbers-O', 'fit-O', 'with-O', 'heterozygous-O', 'atypical-O', 'silent-O', 'genotype-O', '.-O']
['Electrophoretic-O', 'analysis-O', 'of-O', 'plasma-O', 'BChE-O', 'of-O', 'the-O', 'proband-O', 'and-O', 'his-O', 'mother-O', 'showed-O', 'that-O', 'patient-O', 'has-O', 'a-O', 'reduced-O', 'amount-O', 'of-O', 'tetrameric-O', 'enzyme-O', 'in-O', 'plasma-O', 'and-O', 'that-O', 'minor-O', 'fast-O', 'moving-O', 'BChE-O', 'components-O', ':-O', 'monomer-O', ',-O', 'dimer-O', ',-O', 'and-O', 'monomer-O', ',-O', 'albumin-O', 'conjugate-O', 'are-O', 'missing-O', '.-O']
['Kinetic-O', 'analysis-O', 'showed-O', 'that-O', 'the-O', 'p-O', '.-O']
['Val204Asp-B-Disease', '/', 'p-O', '.-O']
['Asp70Gly-B-Chemical', ',-O', 'p-O', '.-O']
['Ala539Thr-O', 'BChE-O', 'displays-O', 'a-O', 'pure-O', 'Michaelian-O', 'behavior-O', 'with-O', 'BTC-B-Chemical', 'as-O', 'the-O', 'substrate-O', '.-O']
['Both-O', 'catalytic-O', 'parameters-O', 'Km-O', '='-O', '265-O', 'uM-O', 'for-O', 'BTC-B-Chemical', ',-O', 'two-O', 'times-O', 'higher-O', 'than-O', 'that-O', 'of-O', 'the-O', 'atypical-O', 'enzyme-O', ',-O', 'and-O', 'a-O', 'low-O', 'Vmax-O', 'are-O', 'consistent-O', 'with-O', 'the-O', 'absence-O', 'of-O', 'activity-O', 'against-O', 'suxamethonium-B-Chemical', '.-O']
['Molecular-O', 'dynamic-O', '(-O', 'MD-O', ')-O', 'simulations-O', 'showed-O', 'that-O', 'the-O', 'overall-O', 'effect-O', 'of-O', 'the-O', 'mutation-O', 'p-O', '.-O']
['Val204Asp-B-Chemical', 'is-O', 'disruption-O', 'of-O', 'hydrogen-B-Chemical']
['Delayed-O', 'anemia-B-Disease', 'after-O', 'treatment-O', 'with-O', 'injectable-O', 'artesunate-B-Chemical', 'in-O', 'the-O', 'Democratic-O', 'Republic-O', 'of-O', 'the-O', 'Congo-O', ':-O', 'a-O', 'manageable-O', 'issue-O', '.-O']
['Cases-O', 'of-O', 'delayed-O', 'hemolytic-B-Disease', 'anemia-I-Disease', 'have-O', 'been-O', 'described-O', 'after-O', 'treatment-O', 'with-O', 'injectable-O', 'artesunate-B-Chemical', ',-O', 'the-O', 'current-O', 'World-O', 'Health-O', 'Organization-O', '(-O', 'WHO-O', ')-O', 'recommended-O', 'first-O', ',-O', 'line-O', 'drug-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'severe-O', 'malaria-B-Disease', '.-O']
['A-O', 'total-O', 'of-O', '350-O', 'patients-O', '(-O', '215-O', '[', '61-O', '.-O']
['4-O', '%-O', '5-O', 'years-O', 'of-O', 'age-O', 'and-O', '135-O', '[-O', '38-O', '.-O']
['6-O', '%>-O', '5-O', 'years-O', 'of-O', 'age-O', ')-O', 'were-O', 'followed-O', ',-O', 'up-O', 'after-O', 'treatment-O', 'with-O', 'injectable-O', 'artesunate-B-Chemical', 'for-O', 'severe-O', 'malaria-B-Disease', 'in-O', 'hospitals-O', 'and-O', 'health-O', 'centers-O', 'of-O', 'the-O', 'Democratic-O', 'Republic-O', 'of-O', 'the-O', 'Congo-O', '.-O']
['Complete-O', 'series-O', 'of-O', 'hemoglobin-O', '(-O', 'Hb-O', ')-O', 'measurements-O', 'were-O', 'available-O', 'for-O', '201-O', 'patients-O', '.-O']
['A-O', 'decrease-O', 'in-O', 'Hb-O', 'levels-O', 'between-O', '2-O', 'and-O', '5-O', 'g-O', '/-O', 'dL-O', 'was-O', 'detected-O', 'in-O', '23-O', '(-O', '11-O', '.-O']
['4-O', ')-O', 'patients-O', 'during-O', 'the-O', 'follow-O', ',-O', 'up-O', 'period-O', '.-O']
['For-O', 'five-O', 'patients-O', ',-O', 'Hb-O', 'levels-O', 'decreased-O', 'below-O', '5-O', 'g-O', '/-O', 'dL-O', 'during-O', 'at-O', 'least-O', 'one-O', 'follow-O', '--O', 'up-O', 'visit-O', '.-O']
['All-O', 'cases-O', 'of-O', 'delayed-O', 'anemia-B-Disease']
['Regulation-O', 'of-O', 'signal-O', 'transducer-O', 'and-O', 'activator-O', 'of-O', 'transcription-O', '3-O', 'and-O', 'apoptotic-O', 'pathways-O', 'by-O', 'betaine-B-Chemical', 'attenuates-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'acute-O', 'myocardial-B-Disease', 'injury-I-Disease', 'in-O', 'rats-O', '.-O']
['The-O', 'present-O', 'study-O', 'was-O', 'designed-O', 'to-O', 'investigate-O', 'the-O', 'cardioprotective-O', 'effects-O', 'of-O', 'betaine-B-Chemical', 'on-O', 'acute-O', 'myocardial-B-Disease', 'ischemia-I-Disease', 'induced-O', 'experimentally-O', 'in-O', 'rats-O', 'focusing-O', 'on-O', 'regulation-O', 'of-O', 'signal-O', 'transducer-O', 'and-O', 'activator-O', 'of-O', 'transcription-O', '3-O', '(-O', 'STAT3-O', ')-O', 'and-O', 'apoptotic-O', 'pathways-O', 'as-O', 'the-O', 'potential-O', 'mechanism-O', 'underlying-O', 'the-O', 'drug-O', 'effect-O', '.-O']
['Male-O', 'Sprague-O', 'Dawley-O', 'rats-O', 'were-O', 'treated-O', 'with-O', 'betaine-B-Chemical', '(-O', '100-O', ',-O', '200-O', ',-O', 'and-O', '400-O', 'mg-O', '/-O', 'kg-O', ')-O', 'orally-O', 'for-O', '40-O', 'days-O', '.-O']
['Acute-O', 'myocardial-B-Disease', 'ischemic-B-Disease', 'injury-I-Disease', 'was-O', 'induced-O', 'in-O', 'rats-O', 'by-O', 'subcutaneous-O', 'injection-O', 'of-O', 'isoproterenol-B-Chemical', '(-O', '85-O', 'mg-O', '/-O', 'kg-O', ')-O', 'for-O', 'two-O', 'consecutive-O', 'days-O', '.-O']
['Serum-O', 'cardiac-O', 'marker-O', 'enzyme-O', ',-O', 'histopathological-O', 'variables-O', 'and-O', 'expression-O', 'of-O', 'protein-O', 'levels-O', 'were-O', 'analyzed-O', '.-O']
['Oral-O', 'administration-O', 'of-O', 'betaine-B-Chemical', '(-O', '200-O', 'and-O', '400-O', 'mg-O', '/-O', 'kg-O', ')-O', 'significantly-O', 'reduced-O', 'the-O', 'level-O', 'of-O', 'cardiac-O', 'marker-O', 'enzyme-O', 'in-O', 'the-O', 'serum-O', 'and-O', 'prevented-O', 'left-O', 'ventricular-O', 'remodeling-O', '.-O']
['Western-O', 'blot-O', 'analysis-O', 'showed-O', 'that-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'phosphorylation-O', 'of-O', 'STAT3-O', 'was-O', 'maintained-O', 'or-O', 'further-O', 'enhanced-O', 'by-O', 'betaine-B-Chemical', 'treatment-O', 'in-O', 'myocardium-O', '.-O']
['Furthermore-O', ',-O', 'betaine-B-Chemical', '(-O', '200-O', 'and-O', '400-O', 'mg-O', '/-O', 'kg-O', ')-O', 'treatment-O', 'increased-O', 'the-O', 'ventricular-O', 'expression-O', 'of-O', 'Bcl-O', ',-O', '2-O', 'and-O', 'reduced-O', 'the-O', 'level-O', 'of-O', 'Bax-O', ',-O', 'therefore-O', 'causing-O', 'a-O', 'significant-O', 'increase-O', 'in-O', 'the-O', 'ratio-O', 'of-O', 'Bcl-O', ',-O', '2-O', '/-O', 'Bax-O', '.-O']
['The-O', 'protective-O', 'role-O', 'of-O', 'betaine-B-Chemical', 'on-O', 'myocardial-B-Disease', 'damage-I-Disease', 'was-O', 'further-O', 'confirmed-O', 'by-O', 'histopathological-O', 'examination-O', '.-O']
['In-O', 'summary-O', ',-O', 'our-O', 'results-O', 'showed-O', 'that-O', 'betaine-B-Chemical', 'pretreatment-O', 'attenuated-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'acute-B-Disease', 'myocardial-B-Disease', 'ischemia-I-Disease']
['Quetiapine-B-Chemical', ',-O', 'induced-O', 'neutropenia-B-Disease', 'in-O', 'a-O', 'bipolar-B-Disease', 'patient-O', 'with-O', 'hepatocellular-B-Disease', 'carcinoma-I-Disease', '.-O']
['OBJECTIVE-O', ':-O', 'Quetiapine-B-Chemical', 'is-O', 'a-O', 'dibenzothiazepine-O', 'derivative-O', ',-O', 'similar-O', 'to-O', 'clozapine-B-Chemical', ',-O', 'which-O', 'has-O', 'the-O', 'highest-O', 'risk-O', 'of-O', 'causing-O', 'blood-B-Disease', 'dyscrasias-I-Disease', ',-O', 'especially-O', 'neutropenia-B-Disease', '.-O']
['There-O', 'are-O', 'some-O', 'case-O', 'reports-O', 'about-O', 'this-O', 'side-O', 'effect-O', 'of-O', 'quetiapine-B-Chemical', ',-O', 'but-O', 'possible-O', 'risk-O', 'factors-O', 'are-O', 'seldom-O', 'discussed-O', 'and-O', 'identified-O', '.-O']
['A-O', 'case-O', 'of-O', 'a-O', 'patient-O', 'with-O', 'hepatocellular-B-Disease', 'carcinoma-I-Disease', 'that-O', 'developed-O', 'neutropenia-B-Disease', 'after-O', 'treatment-O', 'with-O', 'quetiapine-B-Chemical', 'is-O', 'described-O', 'here-O', '.-O']
['CASE-O', 'REPORT-O', ':-O', 'A-O', '62-O', ',-O', 'year-O', ',-O', 'old-O', 'Taiwanese-O', 'widow-O', 'with-O', 'bipolar-B-Disease', 'disorder-I-Disease', 'was-O', 'diagnosed-O', 'with-O', 'hepatocellular-B-Disease', 'carcinoma-I-Disease', 'at-O', 'age-O', '60-O', '.-O']
['She-O', 'developed-O', 'leucopenia-B-Disease', 'after-O', 'being-O', 'treated-O', 'with-O', 'quetiapine-B-Chemical', '.-O']
['After-O', 'quetiapine-B-Chemical', 'was-O', 'discontinued-O', ',-O', 'her-O', 'white-O', 'blood-O', 'cell-O', 'count-O', 'returned-O', 'to-O', 'normal-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Although-O', 'neutropenia-B-Disease', 'is-O', 'not-O', 'a-O', 'common-O', 'side-O', 'effect-O', 'of-O', 'quetiapine-B-Chemical', ',-O', 'physicians-O', 'should-O', 'be-O', 'cautious-O', 'about-O', 'its-O', 'presentation-O', 'and-O', 'associated-O', 'risk-O', 'factors-O', '.-O']
['Hepatic-B-Disease', 'dysfunction-I-Disease', 'may-O', 'be-O', 'one-O', 'of-O', 'the-O', 'possible-O', 'risk-O', 'factors-O', ',-O', 'and-O', 'concomitant-O', 'fever-O', 'may-O', 'be-O', 'a-O', 'diagnostic-O', 'marker-O', 'for-O', 'adverse-O', 'reaction-O', 'to-O', 'quetiapine-B-Chemical']
['Lateral-O', 'antebrachial-O', 'cutaneous-O', 'neuropathy-B-Disease', 'after-O', 'steroid-B-Chemical', 'injection-O', 'at-O', 'lateral-O', 'epicondyle-O', '.-O']
['BACKGROUND-O', 'AND-O', 'OBJECTIVES-O', ':-O', 'This-O', 'report-O', 'aimed-O', 'to-O', 'present-O', 'a-O', 'case-O', 'of-O', 'lateral-B-Disease', 'antebrachial-O', 'cutaneous-O', 'neuropathy-I-Disease', '(-O', 'LACNP-I-Disease', ')-O', 'that-O', 'occurred-O', 'after-O', 'a-O', 'steroid-B-Chemical', 'injection-O', 'in-O', 'the-O', 'lateral-O', 'epicondyle-O', 'to-O', 'treat-O', 'lateral-O', 'epicondylitis-B-Disease', 'in-O', 'a-O', '40-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', '.-O']
['MATERIAL-O', 'AND-O', 'METHOD-O', ':', 'A-O', '40-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'presented-O', 'with-O', 'decreased-O', 'sensation-O', 'and-O', 'paresthesia-B-Disease', 'over-O', 'her-O', 'right-O', 'lateral-O', 'forearm-O', ';', 'the-O', 'paresthesia-B-Disease', 'had-O', 'occurred-O', 'after-O', 'a-O', 'steroid-B-Chemical', 'injection-O', 'in-O', 'the-O', 'right-O', 'lateral-O', 'epicondyle-O', '3-O', 'months-O', 'before-O', '.-O']
['Her-O', 'sensation-O', 'of-O', 'light-O', 'touch-O', 'and-O', 'pain-B-Disease', 'was-O', 'diminished-O', 'over-O', 'the-O', 'lateral-O', 'side-O', 'of-O', 'the-O', 'right-O', 'forearm-O', 'and-O', 'wrist-O', 'area-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'sensory-O', 'action-O', 'potential-O', 'amplitude-O', 'of-O', 'the-O', 'right-O', 'lateral-O', 'antebrachial-O', 'cutaneous-O', 'nerve-O', '(-O', 'LACN-O', ')-O', '(-O', '6-O', '.-O']
['2-O', 'uV-O', ')-O', 'was-O', 'lower-O', 'than-O', 'that-O', 'of-O', 'the-O', 'left-O', '(-O', '13-O', '.-O']
['1-O', 'uV-O', ').-O', 'The-O', 'difference-O', 'of-O', 'amplitude-O', 'between-O', 'both-O', 'sides-O', 'was-O', 'significant-O', 'because-O', 'there-O', 'was-O', 'more-O', 'than-O', 'a-O', '50-O', '%-O', 'reduction-O', '.-O']
['She-O', 'was-O', 'diagnosed-O', 'with-O', 'right-O', 'LACNP-B-Disease', '(-O', 'mainly-O', 'axonal-O', 'involvement-O', ')-O', 'on-O', 'the-O', 'basis-O', 'of-O', 'the-O', 'clinical-O', 'manifestation-O', 'and-O', 'the-O', 'electrodiagnostic-O', 'findings-O', '.-O']
['Her-O', 'symptoms-O', 'improved-O', 'through-O', 'physical-O', 'therapy-O', 'but-O', 'persisted-O', 'to-O', 'some-O', 'degree-O', '.-O']
['CONCLUSION-O', ':-O', 'This-O', 'report-O', 'describes-O', 'the-O', 'case-O', 'of-O', 'a-O', 'woman-O', 'with-O', 'LACNP-B-Disease', 'that-O', 'developed-O', 'after-O', 'a-O', 'steroid-B-Chemical', 'injection-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'lateral-O', 'epicondylitis-B-Disease']
['Curcumin-B-Chemical', 'prevents-O', 'maleate-I-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease', ':-O', 'relation-O', 'to-O', 'hemodynamic-O', 'alterations-O', ',-O', 'oxidative-O', 'stress-O', ',-O', 'mitochondrial-O', 'oxygen-B-Chemical', 'consumption-O', 'and-O', 'activity-O', 'of-O', 'respiratory-O', 'complex-O', 'I-O', '.-O']
['The-O', 'potential-O', 'protective-O', 'effect-O', 'of-O', 'the-O', 'dietary-O', 'antioxidant-O', 'curcumin-B-Chemical', '(-O', '120-O', 'mg-O', '/-O', 'Kg-O', '/-O', 'day-O', 'for-O', '6-O', 'days-O', ')-O', 'against-O', 'the-O', 'renal-B-Disease', 'injury-I-Disease', 'induced-O', 'by-O', 'maleate-B-Chemical', 'was-O', 'evaluated-O', '.-O']
['Tubular-B-Disease', 'proteinuria-I-Disease', 'and-O', 'oxidative-O', 'stress-O', 'were-O', 'induced-O', 'by-O', 'a-O', 'single-O', 'injection-O', 'of-O', 'maleate-B-Chemical', '(-O', '400-O', 'mg-O', '/-O', 'kg-O', ')-O', 'in-O', 'rats-O', '.-O']
['Maleate-B-Chemical', ',-O', 'induced-O', 'renal-B-Disease', 'injury-I-Disease', 'included-O', 'increase-O', 'in-O', 'renal-O', 'vascular-O', 'resistance-O', 'and-O', 'in-O', 'the-O', 'urinary-O', 'excretion-O', 'of-O', 'total-O', 'protein-O', ',-O', 'glucose-B-Chemical', ',-O', 'sodium-B-Chemical', ',-O', 'neutrophil-O', 'gelatinase-O', ',-O', 'associated-O', 'lipocalin-O', '(-O', 'NGAL-O', ')-O', 'and-O', 'N-O', '-O', 'acetyl-O', 'b-O', '-O', 'D-O', '-O', 'glucosaminidase-O', '(-O', 'NAG-O', ')-O', 'upregulation-O', 'of-O', 'kidney-O', 'injury-O', 'molecule-O', '(-O', 'KIM-O', ')-O', '1-O', ',-O', 'decrease-O', 'in-O', 'renal-O', 'blood-O', 'flow-O', 'and-O', 'claudin-O', ',-O', '2-O', 'expression-O', 'besides-O', 'of-O', 'necrosis-O', 'and-O', 'apoptosis-O', 'of-O', 'tubular-O', 'cells-O', 'on-O', '24-O', 'h-O', '.-O']
['Oxidative-O', 'stress-O', 'was-O', 'determined-O', 'by-O', 'measuring-O', 'the-O', 'oxidation-O', 'of-O', 'lipids-O', 'and-O', 'proteins-O', 'and-O', 'diminution-O', 'in-O', 'renal-O', 'Nrf2-O', 'levels-O', '.-O']
['Studies-O', 'were-O', 'also-O', 'conducted-O', 'in-O', 'renal-O', 'epithelial-O', 'LLC-O', ',-O', 'PK1-O', 'cells-O', 'and-O', 'in-O', 'mitochondria-O', 'isolated-O', 'from-O', 'kidneys-O', 'of-O', 'all-O', 'the-O', 'experimental-O', 'groups-O', '.-O']
['Maleate-I-Chemical', 'induced-O', 'cell-O', 'damage-O', 'and-O', 'reactive-O', 'oxygen-B-Chemical', 'species-O', '(-O', 'ROS-O', ')-O', 'production-O', 'in-O', 'LLC-O', ',', 'PK1-O', 'cells-O', 'in-O', 'culture-O', '.-O']
['In-O', 'addition-O', ',-O', 'maleate-I-Chemical', 'treatment-O', 'reduced-O', 'oxygen-B-Chemical', 'consumption-O', 'in-O', 'ADP-B-Chemical', ',-O', 'stimulated-O', 'mitochondria-O', 'and-O', 'diminished-O', 'respiratory-O', 'control-O', 'index-O', 'when-O', 'using-O', 'malate-B-Chemical', '/-O', 'glutamate-B-Chemical', 'as-O', 'substrate-O', '.-O']
['The-O', 'activities-O', 'of-O', 'both-O', 'complex-O', 'I-O', 'and-O', 'aconitase-O', 'were-O', 'also-O', 'diminished-O', '.-O']
['All-O', 'the-O', 'above-O', ',-O', 'described-O', 'alterations-O', 'were-O', 'prevented-O', 'by-O', 'curcumin-B-Chemical', '.-O']
['It-O', 'is-O', 'concluded-O', 'that-O', 'curcumin-B-Chemical', 'is-O', 'able-O', 'to-O', 'attenuate-O', 'in-O', 'vivo-O', 'maleate-I-Chemical', ',-O', 'induced-O', 'nephropathy-B-Disease', 'and-O', 'in-O', 'vitro-O', 'cell-O', 'damage-O', '.-O']
['The-O', 'in-O', 'vivo-O', 'protection-O', 'was-O', 'associated-O', 'to-O', 'the-O', 'prevention-O', 'of-O', 'oxidative-O', 'stress-O', 'and-O', 'preservation-O', 'of-O', 'mitochondrial-O', 'oxygen-O']
['Incidence-O', 'of-O', 'solid-O', 'tumours-B-Disease', 'among-O', 'pesticide-O', 'applicators-O', 'exposed-O', 'to-O', 'the-O', 'organophosphate-B-Chemical', 'insecticide-O', 'diazinon-B-Chemical', 'in-O', 'the-O', 'Agricultural-O', 'Health-O', 'Study-O', ':-O', 'an-O', 'updated-O', 'analysis-O', '.-O']
['OBJECTIVE-O', ':-O', 'Diazinon-B-Chemical', ',-O', 'a-O', 'common-O', 'organophosphate-O', 'insecticide-O', 'with-O', 'genotoxic-O', 'properties-O', ',-O', 'was-O', 'previously-O', 'associated-O', 'with-O', 'lung-B-Disease', 'cancer-I-Disease', 'in-O', 'the-O', 'Agricultural-O', 'Health-O', 'Study-O', '(-O', 'AHS-O', ')-O', 'cohort-O', ',-O', 'but-O', 'few-O', 'other-O', 'epidemiological-O', 'studies-O', 'have-O', 'examined-O', 'diazinon-B-Chemical', ',-O', 'associated-O', 'cancer-B-Disease', 'risk-O', '.-O']
['We-O', 'used-O', 'updated-O', 'diazinon-B-Chemical', 'exposure-O', 'and-O', 'cancer-B-Disease', 'incidence-O', 'information-O', 'to-O', 'evaluate-O', 'solid-O', 'tumour-I-Disease', 'risk-O', 'in-O', 'the-O', 'AHS-O', '.-O']
['METHODS-O', ':', 'Male-O', 'pesticide-O', 'applicators-O', 'in-O', 'Iowa-O', 'and-O', 'North-O', 'Carolina-O', 'reported-O', 'lifetime-O', 'diazinon-Chemical', 'use-O', 'at-O', 'enrolment-O', '(-O', '1993-O', ',-O', '1997-O', ')-O', 'and-O', 'follow-O', ',-O', 'up-O', '(-O', '1998-O', ',-O', '2005-O', ')-O', ';', 'cancer-Disease', 'incidence-O', 'was-O', 'assessed-O', 'through-O', '2010-O', '(-O', 'North-O', 'Carolina-O', ')/', '2011-O', '(-O', 'Iowa-O', ').', 'Among-O', 'applicators-O', 'with-O', 'usage-O', 'information-O', 'sufficient-O', 'to-O', 'evaluate-O', 'exposure-O', ',', 'response-O', 'patterns-O', ',', 'we-O', 'used-O', 'Poisson-O', 'regression-O', 'to-O', 'estimate-O', 'adjusted-O', 'rate-O', 'ratios-O', '(-O', 'RRs-O', ')-O', 'and-O', '95-O', '%-O', 'CI-O', 'for-O', 'cancer-Disease', 'sites-O', 'with-O', '>-O', '10-O', 'exposed-O', 'cases-O', 'for-O', 'both-O', 'lifetime-O', '(-O', 'LT-O', ')-O', 'exposure-O', 'days-O', 'and-O', 'intensity-O', ',', 'weighted-O', '(-O', 'IW-O', ')-O', 'lifetime-O', 'exposure-O', 'days-O', '(-O', 'accounting-O', 'for-O', 'factors-O', 'impacting-O', 'exposure-O', ').', 'RESULTS-O', ':', 'We-O', 'observed-O', 'elevated-O', 'lung-Disease', 'cancer-Disease', 'risks-O', '(-O', 'N-O', '=', '283-O', ')-O', 'among-O', 'applicators-O', 'with-O', 'the-O', 'greatest-O', 'number-O', 'of-O', 'LT-O', '(-O', 'RR-O', '=', '1-O', '.-O']
['60-O', ';-O', '95-O', '%-O', 'CI-O', '1-O', '.-O']
['11-O', 'to-O', '2-O', '.-O']
['31-O', ';-O', 'Ptrend-O', '=', '0-O', '.-O']
['02-O', ')-O', 'and-O', 'IW-O', 'days-O', 'of-O', 'diazinon-B-Chemical', 'use-O', '(-O', 'RR-O', '=-O', '1-O', '.-O']
['41-O', ';-O', '95-O', '%-O', 'CI-O', '0-O', '.-O']
['98-O', 'to-O', '2-O', '.-O']
['04-O', ';-O', 'Ptrend-O', '=', '0-O', '.-O']
['08-O', ').-O', 'Kidney-B-Disease', 'cancer-I-Disease', '(-O', 'N-O', '=-O', '94-O', ')-O', 'risks-O', 'were-O', 'non-O', ',-O', 'significantly-O', 'elevated-O', '(-O', 'RRLT-O', 'days-O', '=-O', '1-O', '.-O']
['77-O', ';-O', '95-O', '%-O', 'CI-O', '0-O', '.-O']
['90-O', 'to-O', '3-O', '.-O']
['51-O', ';-O', 'Ptrend-O', '=', '0-O', '.-O']
['09-O', ';-O', 'RRIW-O', 'days-O', '1-O', '.-O']
['37-O', ';-O', '95-O', '%-O', 'CI-O', '0-O', '.-O']
['64-O', 'to-O', '2-O', '.-O']
['92-O', ';-O', 'Ptrend-O', '=-O', '0-O', '.-O']
['50-O', ')-O', ',', 'as-O', 'were-O', 'risks-O', 'for-O', 'aggressive-O', 'prostate-B-Disease', 'cancer-I-Disease', '(-O', 'N-O', '=', '656-O', ').-O', 'CONCLUSIONS-O', ':-O', 'Our-O', 'updated-O', 'evaluation-O', 'of-O', 'diazinon-B-Chemical', 'provides-O', 'additional-O', 'evidence-O', 'of-O', 'an-O', 'association-O', 'with-O', 'lung-B-Disease', 'cancer-I-Disease', 'risk-O', '.-O']
['Newly-O', 'identified-O', 'links-O', 'to-O', 'kidney-B-Disease', 'cancer-I-Disease', 'and-O', 'associations-O', 'with-O', 'aggressive-O', 'prostate-B-Disease', 'cancer-I-Disease']
['Associations-O', 'of-O', 'Ozone-B-Chemical', 'and-O', 'PM2-O', '.-O']
['5-O', 'Concentrations-O', 'With-O', 'Parkinson-B-Disease', 'Among-O', 'Participants-O', 'in-O', 'the-O', 'Agricultural-O', 'Health-O', 'Study-O', '.-O']
['OBJECTIVE-O', ':-O', 'This-O', 'study-O', 'describes-O', 'associations-O', 'of-O', 'ozone-B-Chemical', 'and-O', 'fine-O', 'particulate-O', 'matter-O', 'with-O', 'Parkinson-B-Disease', 'disease-I-Disease', 'observed-O', 'among-O', 'farmers-O', 'in-O', 'North-O', 'Carolina-O', 'and-O', 'Iowa-O', '.-O']
['METHODS-O', ':-O', 'We-O', 'used-O', 'logistic-O', 'regression-O', 'to-O', 'determine-O', 'the-O', 'associations-O', 'of-O', 'these-O', 'pollutants-O', 'with-O', 'self-O', ',-O', 'reported-O', ',-O', 'doctor-O', ',-O', 'diagnosed-O', 'Parkinson-B-Disease', 'disease-I-Disease', '.-O']
['Daily-O', 'predicted-O', 'pollutant-O', 'concentrations-O', 'were-O', 'used-O', 'to-O', 'derive-O', 'surrogates-O', 'of-O', 'long-O', ',-O', 'term-O', 'exposure-O', 'and-O', 'link-O', 'them-O', 'to-O', 'study-O', 'participants-O', 'x-O', 'geocoded-O', 'addresses-O', '.-O']
['RESULTS-O', ':-O', 'We-O', 'observed-O', 'positive-O', 'associations-O', 'of-O', 'Parkinson-B-Disease', 'disease-I-Disease', 'with-O', 'ozone-B-Chemical', '(-O', 'odds-O', 'ratio-O', '=', '1-O', '.-O']
['39-O', ';-O', '95-O', '%-O', 'CI-O', ':-O', '0-O', '.-O']
['98-O', 'to-O', '1-O', '.-O']
['98-O', ')-O', 'and-O', 'fine-O', 'particulate-O', 'matter-O', '(-O', 'odds-O', 'ratio-O', '=-O', '1-O', '.-O']
['34-O', ';-O', '95-O', '%-O', 'CI-O', ':-O', '0-O', '.-O']
['93-O', 'to-O', '1-O', '.-O']
['93-O', ')-O', 'in-O', 'North-O', 'Carolina-O', 'but-O', 'not-O', 'in-O', 'Iowa-O', '.-O']
['CONCLUSIONS-O', ':-O', 'The-O', 'plausibility-O', 'of-O', 'an-O', 'effect-O', 'of-O', 'ambient-O', 'concentrations-O', 'of-O', 'these-O', 'pollutants-O', 'on-O', 'Parkinson-B-Disease', 'disease-I-Disease']
['Low-O', 'functional-O', 'programming-O', 'of-O', 'renal-O', 'AT2R-O', 'mediates-O', 'the-O', 'developmental-O', 'origin-O', 'of-O', 'glomerulosclerosis-B-Disease', 'in-O', 'adult-O', 'offspring-O', 'induced-O', 'by-O', 'prenatal-O', 'caffeine-B-Chemical', 'exposure-O', '.-O']
['UNASSIGNED-O', ':-O', 'Our-O', 'previous-O', 'study-O', 'has-O', 'indicated-O', 'that-O', 'prenatal-O', 'caffeine-B-Chemical', 'exposure-O', '(-O', 'PCE-O', ')', 'could-O', 'induce-O', 'intrauterine-B-Disease', 'growth-O', 'retardation-I-Disease', '(-O', 'IUGR-I-Disease', ')', 'of-O', 'offspring-O', '.-O']
['Recent-O', 'research-O', 'suggested-O', 'that-O', 'IUGR-B-Disease', 'is-O', 'a-O', 'risk-O', 'factor-O', 'for-O', 'glomerulosclerosis-B-Disease', '.-O']
['However-O', ',-O', 'whether-O', 'PCE-B-Chemical', 'could-O', 'induce-O', 'glomerulosclerosis-B-Disease', 'and-O', 'its-O', 'underlying-O', 'mechanisms-O', 'remain-O', 'unknown-O', '.-O']
['This-O', 'study-O', 'aimed-O', 'to-O', 'demonstrate-O', 'the-O', 'induction-O', 'to-O', 'glomerulosclerosis-B-Disease', 'in-O', 'adult-O', 'offspring-O', 'by-O', 'PCE-B-Chemical', 'and-O', 'its-O', 'intrauterine-O', 'programming-O', 'mechanisms-O', '.-O']
['A-O', 'rat-O', 'model-O', 'of-O', 'IUGR-B-Disease', 'was-O', 'established-O', 'by-O', 'PCE-B-Chemical', ',', 'male-O', 'fetuses-O', 'and-O', 'adult-O', 'offspring-O', 'at-O', 'the-O', 'age-O', 'of-O', 'postnatal-O', 'week-O', '24-O', 'were-O', 'euthanized-O', '.-O']
['The-O', 'results-O', 'revealed-O', 'that-O', 'the-O', 'adult-O', 'offspring-O', 'kidneys-O', 'in-O', 'the-O', 'PCE-O', 'group-O', 'exhibited-O', 'glomerulosclerosis-B-Disease', 'as-O', 'well-O', 'as-O', 'interstitial-O', 'fibrosis-B-Disease', ',-O', 'accompanied-O', 'by-O', 'elevated-O', 'levels-O', 'of-O', 'serum-O', 'creatinine-B-Chemical', 'and-O', 'urine-O', 'protein-O', '.-O']
['Renal-O', 'angiotensin-B-Chemical', 'II-I-Chemical', 'receptor-O', 'type-O', '2-O', '(-O', 'AT2R-O', ')-O', 'gene-O', 'expression-O', 'in-O', 'adult-O', 'offspring-O', 'was-O', 'reduced-O', 'by-O', 'PCE-O', ',-O', 'whereas-O', 'the-O', 'renal-O', 'angiotensin-B-Chemical', 'II-I-Chemical', 'receptor-O', 'type-O', '1a-O', '(-O', 'AT1aR-O', ')/-O', 'AT2R-O', 'expression-O', 'ratio-O', 'was-O', 'increased-O', '.-O']
['The-O', 'fetal-O', 'kidneys-O', 'in-O', 'the-O', 'PCE-B-Chemical', 'group-O', 'displayed-O', 'an-O', 'enlarged-O', 'Bowman-O', 'x-O', 's-O', 'space-O', 'and-O', 'a-O', 'shrunken-O', 'glomerular-O', 'tuft-O', ',-O', 'accompanied-O', 'by-O', 'a-O', 'reduced-O', 'cortex-O', 'width-O', 'and-O', 'an-O', 'increase-O', 'in-O', 'the-O', 'nephrogenic-O', 'zone-O', '/-O', 'cortical-O', 'zone-O', 'ratio-O', '.-O']
['Observation-O', 'by-O', 'electronic-O', 'microscope-O', 'revealed-O', 'structural-O', 'damage-O', 'of-O', 'podocytes-O', ';-O', 'the-O', 'reduced-O', 'expression-O', 'level-O', 'of-O', 'podocyte-O', 'marker-O', 'genes-O', ',-O', 'nephrin-O', 'and-O', 'podocin-O', ',-O', 'was-O', 'also-O', 'detected-O', 'by-O', 'q-O', ',', 'PCR-O', '.-O']
['Moreover-O', ',-O', 'AT2R-O', 'gene-O', 'and-O', 'protein-O', 'expressions-O', 'in-O', 'fetal-O', 'kidneys-O', 'were-O', 'inhibited-O', 'by-O', 'PCE-O', ',-O', 'associated-O', 'with-O', 'the-O', 'repression-O', 'of-O', 'the-O', 'gene-O', 'expression-O', 'of-O', 'glial-O', ',-O', 'cell-O', ',-O', 'line-O', ',-O', 'derived-O', 'neurotrophic-O', 'factor-O', '(-O', 'GDNF-O', ')/-O', 'tyrosine-B-Chemical', 'kinase-O', 'receptor-O', '(-O', 'c-O', ',-O', 'Ret-O', ')-O', 'signaling-O', 'pathway-O', '.-O']
['These-O', 'results-O', 'demonstrated-O', 'that-O', 'PCE-B-Chemical', 'could-O', 'induce-O', 'dysplasia-B-Disease', 'of-O', 'fetal-O', 'kidneys-O', 'as-O', 'well-O', 'as-O', 'glomerulosclerosis-B-Disease', 'of-O', 'adult-O', 'offspring-O', ',-O', 'and-O', 'the-O', 'low-O', 'functional-O', 'programming-O', 'of-O', 'renal-O', 'AT2R-O', 'might-O', 'mediate-O', 'the-O', 'developmental-O', 'origin-O', 'of-O', 'adult-O', 'glomerulosclerosis-B-Disease']
['1,3-Butadiene-B-Chemical', ',-O', 'CML-B-Disease', 'and-O', 'the-O', 't-O', '(-O', '9-O', ':', '22-O', ')-O', 'translocation-O', ':-O', 'A-O', 'reality-O', 'check-O', '.-O']
['UNASSIGNED-O', ':', 'Epidemiological-O', 'studies-O', 'of-O', '1,3-butadiene-B-Chemical', 'have-O', 'suggest-O', 'that-O', 'exposures-O', 'to-O', 'humans-O', 'are-O', 'associated-O', 'with-O', 'chronic-O', 'myeloid-O', 'leukemia-B-Disease', '(', 'CML-B-Disease', ').', 'CML-B-Disease', 'has-O', 'a-O', 'well-O', ',', 'documented-O', 'association-O', 'with-O', 'ionizing-O', 'radiation-O', ',', 'but-O', 'reports-O', 'of-O', 'associations-O', 'with-O', 'chemical-O', 'exposures-O', 'have-O', 'been-O', 'questioned-O', '.-O']
['Ionizing-O', 'radiation-O', 'is-O', 'capable-O', 'of-O', 'inducing-O', 'the-O', 'requisite-O', 'CML-B-Disease', ',-O', 'associated-O', 't-O', '(-O', '9-O', ':', '22-O', ')-O', 'translocation-O', '(-O', 'Philadelphia-O', 'chromosome-O', ')-O', 'in-O', 'appropriate-O', 'cells-O', 'in-O', 'vitro-O', 'but-O', ',-O', 'thus-O', 'far-O', ',-O', 'chemicals-O', 'have-O', 'not-O', 'shown-O', 'this-O', 'capacity-O', '.-O']
['We-O', 'have-O', 'proposed-O', 'that-O', '1,3-butadiene-B-Chemical', 'metabolites-O', 'be-O', 'so-O', 'tested-O', 'as-O', 'a-O', 'reality-O', 'check-O', 'on-O', 'the-O', 'epidemiological-O', 'reports-O', '.-O']
['In-O', 'order-O', 'to-O', 'conduct-O', 'reliable-O', 'testing-O', 'in-O', 'this-O', 'regard-O', ',-O', 'it-O', 'is-O', 'essential-O', 'that-O', 'a-O', 'positive-O', 'control-O', 'for-O', 'induction-O', 'be-O', 'available-O', '.-O']
['We-O', 'have-O', 'used-O', 'ionizing-O', 'radiation-O', 'to-O', 'develop-O', 'such-O', 'a-O', 'control-O', '.-O']
['Results-O', 'described-O', 'here-O', 'demonstrate-O', 'that-O', 'this-O', 'agent-O', 'does-O', 'in-O', 'fact-O', 'induce-O', 'pathogenic-O', 't-O', '(-O', '9-O', ':O', '22-O', ')-O', 'translocations-O', 'in-O', 'a-O', 'human-O', 'myeloid-O', 'cell-O', 'line-O', 'in-O', 'vitro-O', ',-O', 'but-O', 'does-O', 'so-O', 'at-O', 'low-O', 'frequencies-O', '.-O']
['Conditions-O', 'that-O', 'will-O', 'be-O', 'required-O', 'for-O', 'studies-O', 'of-O', '1,3-butadiene-B-Chemical']
['Cancer-B-Disease', 'incidence-O', 'and-O', 'metolachlor-B-Chemical', 'use-O', 'in-O', 'the-O', 'Agricultural-O', 'Health-O', 'Study-O', ':-O', 'An-O', 'update-O', '.-O']
['UNASSIGNED-O', ':-O', 'Metolachlor-B-Chemical', ',-O', 'a-O', 'widely-O', 'used-O', 'herbicide-O', ',-O', 'is-O', 'classified-O', 'as-O', 'a-O', 'Group-O', 'C-O', 'carcinogen-O', 'by-O', 'the-O', 'U-O', '.-O']
['S-O', '.-O']
['Environmental-O', 'Protection-O', 'Agency-O', 'based-O', 'on-O', 'increased-O', 'liver-B-Disease', 'neoplasms-I-Disease', 'in-O', 'female-O', 'rats-O', '.-O']
['Epidemiologic-O', 'studies-O', 'of-O', 'the-O', 'health-O', 'effects-O', 'of-O', 'metolachlor-B-Chemical', 'have-O', 'been-O', 'limited-O', '.-O']
['The-O', 'Agricultural-O', 'Health-O', 'Study-O', '(-O', 'AHS-O', ')-O', 'is-O', 'a-O', 'prospective-O', 'cohort-O', 'study-O', 'including-O', 'licensed-O', 'private-O', 'and-O', 'commercial-O', 'pesticide-O', 'applicators-O', 'in-O', 'Iowa-O', 'and-O', 'North-O', 'Carolina-O', 'enrolled-O', '1993-O', ',-O', '1997-O', '.-O']
['We-O', 'evaluated-O', 'cancer-B-Disease', 'incidence-O', 'through-O', '2010-O', '/', '2011-O', '(-O', 'NC-O', '/', 'IA-O', ')-O', 'for-O', '49-O', ',', '616-O', 'applicators-O', ',', '53-O', '%-O', 'of-O', 'whom-O', 'reported-O', 'ever-O', 'using-O', 'metolachlor-B-Chemical', '.-O']
['We-O', 'used-O', 'Poisson-O', 'regression-O', 'to-O', 'evaluate-O', 'relations-O', 'between-O', 'two-O', 'metrics-O', 'of-O', 'metolachlor-B-Chemical', 'use-O', '(-O', 'lifetime-O', 'days-O', ',-O', 'intensity-O', ',-O', 'weighted-O', 'lifetime-O', 'days-O', ')-O', 'and-O', 'cancer-B-Disease', 'incidence-O', '.-O']
['We-O', 'saw-O', 'no-O', 'association-O', 'between-O', 'metolachlor-B-Chemical', 'use-O', 'and-O', 'incidence-O', 'of-O', 'all-O', 'cancers-B-Disease', 'combined-O', '(-O', 'n-O', '='-O', '5-O', '-O', '701-O', 'with-O', 'a-O', '5-O', '-O', 'year-O', 'lag-O', ')-O', 'or-O', 'most-O', 'site-O', '-O', 'specific-O', 'cancers-B-Disease', '.-O']
['For-O', 'liver-B-Disease', 'cancer-I-Disease', ',-O', 'in-O', 'analyses-O', 'restricted-O', 'to-O', 'exposed-O', 'workers-O', ',-O', 'elevations-O', 'observed-O', 'at-O', 'higher-O', 'categories-O', 'of-O', 'use-O', 'were-O', 'not-O', 'statistically-O', 'significant-O', '.-O']
['However-O', ',-O', 'trends-O', 'for-O', 'both-O', 'lifetime-O', 'and-O', 'intensity-O', ',-O', 'weighted-O', 'lifetime-O', 'days-O', 'of-O', 'metolachor-B-Chemical', 'use-O', 'were-O', 'positive-O', 'and-O', 'statistically-O', 'significant-O', 'with-O', 'an-O', 'unexposed-O', 'reference-O', 'group-O', '.-O']
['A-O', 'similar-O', 'pattern-O', 'was-O', 'observed-O', 'for-O', 'follicular-B-Disease', 'cell-O', 'lymphoma-I-Disease', ',-O', 'but-O', 'no-O', 'other-O', 'lymphoma-B-Disease', 'subtypes-O', '.-O']
['An-O', 'earlier-O', 'suggestion-O', 'of-O', 'increased-O', 'lung-B-Disease', 'cancer-I-Disease', 'risk-O', 'at-O', 'high-O', 'levels-O', 'of-O', 'metolachlor-B-Chemical', 'use-O', 'in-O', 'this-O', 'cohort-O', 'was-O', 'not-O', 'confirmed-O', 'in-O', 'this-O', 'update-O', '.-O']
['This-O', 'suggestion-O', 'of-O', 'an-O', 'association-O', 'between-O', 'metolachlor-B-Chemical', 'and-O', 'liver-B-Disease', 'cancer-I-Disease', 'among-O', 'pesticide-O', 'applicators-O', 'is-O', 'a-O', 'novel-O', 'finding-O', 'and-O', 'echoes-O', 'observation-O', 'of-O', 'increased-O', 'liver-B-Disease', 'neoplasms-I-Disease', 'in-O', 'some-O', 'animal-O', 'studies-O', '.-O']
['However-O', ',-O', 'our-O', 'findings-O', 'for-O', 'both-O', 'liver-B-Disease', 'cancer-I-Disease', 'and-O', 'follicular-B-Disease', 'cell-I-Disease', 'lymphoma-I-Disease', 'warrant-O', 'follow-O', ',-O', 'up-O', 'to-O', 'better-O', 'differentiate-O', 'effects-O', 'of-O', 'metolachlor-B-Chemical']
['Mechanisms-O', 'Underlying-O', 'Latent-B-Disease', 'Disease-I-Disease', 'Risk-O', 'Associated-O', 'with-O', 'Early-O', ',-O', 'Life-O', 'Arsenic-B-Chemical', 'Exposure-O', ':-O', 'Current-O', 'Research-O', 'Trends-O', 'and-O', 'Scientific-O', 'Gaps-O', '.-O']
['BACKGROUND-O', ':-O', 'Millions-O', 'of-O', 'individuals-O', 'worldwide-O', ',-O', 'particularly-O', 'those-O', 'living-O', 'in-O', 'rural-O', 'and-O', 'developing-O', 'areas-O', ',-O', 'are-O', 'exposed-O', 'to-O', 'harmful-O', 'levels-O', 'of-O', 'inorganic-O', 'arsenic-B-Chemical', '(-O', 'iAs-O', ')-O', 'in-O', 'their-O', 'drinking-O', 'water-O', '.-O']
['Inorganic-O', 'As-B-Chemical', 'exposure-O', 'during-O', 'key-O', 'developmental-O', 'periods-O', 'is-O', 'associated-O', 'with-O', 'a-O', 'variety-O', 'of-O', 'adverse-O', 'health-O', 'effects-O', 'including-O', 'those-O', 'that-O', 'are-O', 'evident-O', 'in-O', 'adulthood-O', '.-O']
['There-O', 'is-O', 'considerable-O', 'interest-O', 'in-O', 'identifying-O', 'the-O', 'molecular-O', 'mechanisms-O', 'that-O', 'relate-O', 'early-O', 'life-O', 'iAs-O', 'exposure-O', 'to-O', 'the-O', 'development-O', 'of-O', 'these-O', 'latent-O', 'diseases-O', ',-O', 'particularly-O', 'in-O', 'relationship-O', 'to-O', 'cancer-B-Disease', '.-O']
['OBJECTIVES-O', ':-O', 'This-O', 'work-O', 'summarizes-O', 'research-O', 'on-O', 'the-O', 'molecular-O', 'mechanisms-O', 'that-O', 'underlie-O', 'the-O', 'increased-O', 'risk-O', 'of-O', 'cancer-B-Disease', 'development-O', 'in-O', 'adulthood-O', 'that-O', 'is-O', 'associated-O', 'with-O', 'early-O', ',-O', 'life-O', 'iAs-B-Chemical', 'exposure-O', '.-O']
['DISCUSSION-O', ':-O', 'Epigenetic-O', 'reprogramming-O', 'that-O', 'imparts-O', 'functional-O', 'changes-O', 'in-O', 'gene-O', 'expression-O', ',-O', 'the-O', 'development-O', 'of-O', 'cancer-B-Disease', 'stem-O', 'cells-O', ',-O', 'and-O', 'immunomodulation-O', 'are-O', 'plausible-O', 'underlying-O', 'mechanisms-O', 'by-O', 'which-O', 'early-O', ',-O', 'life-O', 'iAs-B-Chemical', 'exposure-O', 'elicits-O', 'latent-O', 'carcinogenic-O', 'effects-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Evidence-O', 'is-O', 'mounting-O', 'that-O', 'relates-O', 'early-O', ',-O', 'life-O', 'iAs-B-Chemical', 'exposure-O', 'and-O', 'cancer-B-Disease']
['On-O', 'the-O', 'antiarrhythmic-O', 'activity-O', 'of-O', 'one-O', 'N-O', 'substituted-O', 'piperazine-B-Chemical', 'derivative-O', 'of-O', 'trans-2-amino-3-hydroxy-1,-O', '2,-O', '3,-O', '4-tetrahydroanaphthalene-B-Chemical', '.-O']
['The-O', 'antiarrhythmic-O', 'activity-O', 'of-O', 'the-O', 'compound-O', 'N-(trans-3-hydroxy-1,2,3,4-tetrahydro-2-naphthyl)-N-(3-oxo-3-phenyl-2-methylpropyl)-piperazine-B-Chemical', 'hydrochloride-O', ',-O', 'referred-O', 'to-O', 'as-O', 'P11-O', ',-O', 'is-O', 'studied-O', 'on-O', 'anaesthesized-O', 'cats-O', 'and-O', 'Wistar-O', 'albino-O', 'rats-O', ',-O', 'as-O', 'well-O', 'as-O', 'on-O', 'non-O', ',-O', 'anaesthesized-O', 'rabbits-O', '.-O']
['Four-O', 'types-O', 'of-O', 'experimental-O', 'arrhythmia-B-Disease', 'are-O', 'used-O', '--O', 'with-O', 'BaCl2-B-Chemical', ',-O', 'with-O', 'chloroform-B-Chemical', ',-O', 'adrenaline-B-Chemical', ',-O', 'with-O', 'strophantine-B-Chemical', 'G-O', 'and-O', 'with-O', 'aconitine-B-Chemical', '.-O']
['The-O', 'compound-O', 'P11-B-Chemical', 'is-O', 'introduced-O', 'in-O', 'doses-O', 'of-O', '0-O', '.-O']
['25-O', 'and-O', '0-O', '.-O']
['50-O', 'mg-O', '/-O', 'kg-O', 'intravenously-O', 'and-O', '10-O', 'mg-O', '/-O', 'kg-O', 'orally-O', '.-O']
['The-O', 'compound-O', 'manifests-O', 'antiarrhythmic-O', 'activity-O', 'in-O', 'all-O', 'models-O', 'of-O', 'experimental-O', 'arrhythmia-B-Disease', 'used-O', ',-O', 'causing-O', 'greatest-O', 'inhibition-O', 'on-O', 'the-O', 'arrhythmia-B-Disease', 'induced-O', 'by-O', 'chloroform-B-Chemical', ',-O', 'adrenaline-B-Chemical', '(-O', 'in-O', '90-O', 'per-O', 'cent-O', ')-O', 'and-O', 'with-O', 'BaCl2-B-Chemical']
['Experimental-O', 'progressive-O', 'muscular-B-Disease', 'dystrophy-I-Disease', 'and-O', 'its-O', 'treatment-O', 'with-O', 'high-O', 'doses-O', 'anabolizing-O', 'agents-O', '.-O']
['We-O', 'are-O', 'still-O', 'a-O', 'long-O', 'way-O', 'from-O', 'discovering-O', 'an-O', 'unequivocal-O', 'pathogenetic-O', 'interpretation-O', 'of-O', 'progressive-B-Disease', 'muscular-B-Disease', 'dystrophy-I-Disease', 'in-O', 'man-O', '.-O']
['Noteworthy-O', 'efforts-O', 'have-O', 'been-O', 'made-O', 'in-O', 'the-O', 'experimental-O', 'field-O', ';-O', 'a-O', 'recessive-O', 'autosomic-O', 'form-O', 'found-O', 'in-O', 'the-O', 'mouse-O', 'seems-O', 'to-O', 'bear-O', 'the-O', 'closest-O', 'resemblance-O', 'to-O', 'the-O', 'human-O', 'form-O', 'from-O', 'the-O', 'genetic-O', 'point-O', 'of-O', 'view-O', '.-O']
['Myopathy-B-Disease', 'due-O', 'to-O', 'lack-O', 'of-O', 'vitamin-B-Chemical', 'E-I-Chemical', 'and-O', 'myopathy-B-Disease', 'induced-O', 'by-O', 'certain-O', 'viruses-O', 'have-O', 'much-O', 'in-O', 'common-O', 'anatomically-O', 'and-O', 'pathologically-O', 'with-O', 'the-O', 'human-O', 'form-O', '.-O']
['The-O', 'authors-O', 'induced-O', 'myodystrophy-B-Disease', 'in-O', 'the-O', 'rat-O', 'by-O', 'giving-O', 'it-O', 'a-O', 'diet-O', 'lacking-O', 'in-O', 'vitamin-B-Chemical', 'E-I-Chemical', '.-O']
['The-O', 'pharmacological-O', 'characteristics-O', 'of-O', 'vitamin-B-Chemical', 'E-I-Chemical', 'and-O', 'the-O', 'degenerative-O', 'changes-O', 'brought-O', 'about-O', 'by-O', 'its-O', 'deficiency-O', ',-O', 'especially-O', 'in-O', 'the-O', 'muscles-O', ',-O', 'are-O', 'illustrated-O', '.-O']
['It-O', 'is-O', 'thus-O', 'confirmed-O', 'that-O', 'the-O', 'histological-O', 'characteristics-O', 'of-O', 'myopathic-B-Disease', 'rat-O', 'muscle-O', 'induced-O', 'experimentally-O', 'are-O', 'extraordinarily-O', 'similar-O', 'to-O', 'those-O', 'of-O', 'human-O', 'myopathy-B-Disease', 'as-O', 'confirmed-O', 'during-O', 'biopsies-O', 'performed-O', 'at-O', 'the-O', 'Orthopaedic-O', 'Traumatological-O', 'Centre-O', ',-O', 'Florence-O', '.-O']
['The-O', 'encouraging-O', 'results-O', 'obtained-O', 'in-O', 'various-O', 'authoratative-O', 'departments-O', 'in-O', 'myopathic-B-Disease', 'patients-O', 'by-O', 'using-O', 'anabolizing-O', 'steroids-O', 'have-O', 'encouraged-O', 'the-O', 'authors-O', 'to-O', 'investigate-O', 'the-O', 'beneficial-O', 'effects-O', 'of-O', 'one-O', 'anabolizing-O', 'agent-O', '(-O', 'Dianabol-B-Chemical', ',-O', 'CIBA-O', ')-O', 'at-O', 'high-O', 'doses-O', 'in-O', 'rats-O', 'rendered-O', 'myopathic-B-Disease', 'by-O', 'a-O', 'diet-O', 'deficient-O', 'in-O', 'vitamin-B-Chemical', 'E-O', '.-O']
['In-O', 'this-O', 'way-O', 'they-O', 'obtained-O', 'appreciable-O', 'changes-O', 'in-O', 'body-O', 'weight-O', '(-O', 'increased-O', 'from-O', '50-O', 'to-O', '70-O', 'g-O', 'after-O', 'forty-O', 'days-O', 'at-O', 'a-O', 'dose-O', 'of-O', '5-O', 'mg-O', 'per-O', 'day-O', 'of-O', 'anabolizing-O', 'agent-B-Chemical', '),-O', 'but-O', 'most-O', 'of-O', 'all-O', 'they-O', 'found-O', 'histological-O', 'changes-O', 'due-O', 'to-O', 'x-O', 'regenerative-O', 'x-O', 'changes-O', 'in-O', 'the-O', 'muscle-O', 'tissue-O', ',-O', 'which-O', 'however-O', 'maintained-O', 'its-O', 'myopathic-O', 'characteristics-O', 'in-O', 'the-O', 'control-O', 'animals-O', 'that-O', 'were-O', 'not-O', 'treated-O', 'with-O', 'the-O', 'anabolizing-O', 'agent-B-Chemical', '.-O']
['The-O', 'authors-O', 'conclude-O', 'by-O', 'affirming-O', 'the-O', 'undoubted-O', 'efficacy-O', 'of-O', 'the-O', 'anabolizing-O', 'steroids-B-Chemical', 'in-O', 'experimental-O', 'myopathic-B-Disease', 'disease-O', ',-O', 'but-O', 'they-O', 'have-O', 'reservations-O', 'as-O', 'to-O', 'the-O', 'transfer-O', 'of-O', 'the-O', 'results-O', 'into-O', 'the-O', 'human-O', 'field-O', ',-O', 'where-O', 'high-O', 'dosage-O', 'cannot-O', 'be-O', 'carried-O', 'out-O', 'continuously-O', 'because-O', 'of-O', 'the-O', 'effects-O', 'of-O', 'the-O', 'drug-O', 'on-O', 'virility-O', ';-O', 'because-O', 'the-O', 'tissue-O', 'injury-O', 'too-O', 'often-O', 'occurs-O', 'at-O', 'an-O', 'irreversible-O', 'stage-O', 'vis-O', ',-O', 'a-O', ',-O', 'vis-O', 'the-O', 'x-O', 'regeneration-O', 'x-O', 'of-O', 'the-O', 'muscle-O', 'tissue-O', ';-O', 'and-O', 'finally-O', 'because-O', 'the-O', 'dystrophic-O', 'injurious-O', 'agent-O', 'is-O', 'certainly-O', 'not-O', 'the-O', 'lack-O', 'of-O', 'vitamin-O', 'E-B-Chemical']
['Fetal-O', 'risks-O', 'due-O', 'to-O', 'warfarin-B-Chemical', 'therapy-O', 'during-O', 'pregnancy-O', '.-O']
['Two-O', 'mothers-O', 'with-O', 'heart-O', 'valve-B-Disease', 'prosthesis-O', 'were-O', 'treated-O', 'with-O', 'warfarin-B-Chemical', 'during-O', 'pregnancy-O', '.-O']
['In-O', 'the-O', 'first-O', 'case-O', 'a-O', 'caesarean-O', 'section-O', 'was-O', 'done-O', 'one-O', 'week-O', 'after-O', 'replacement-O', 'of-O', 'warfarin-B-Chemical', 'with-O', 'heparin-B-Chemical', '.-O']
['The-O', 'baby-O', 'died-O', 'of-O', 'cerebral-B-Disease', 'and-O', 'pulmonary-B-Disease', 'hemorrhage-I-Disease', '.-O']
['The-O', 'second-O', 'mother-O', 'had-O', 'a-O', 'male-O', 'infant-O', 'by-O', 'caesarean-O', 'section-O', '.-O']
['The-O', 'baby-O', 'showed-O', 'warfarin-B-Chemical', ',-O', 'induced-O', 'embryopathy-B-Disease', 'with-O', 'nasal-B-Disease', 'hypoplasia-I-Disease', 'and-O', 'stippled-O', 'epiphyses-O', '(-O', 'chondrodysplasia-B-Disease', 'punctata-I-Disease', ')-O', '.', 'Nasal-B-Disease', 'hypoplasia-I-Disease', 'with-O', 'or-O', 'without-O', 'stippled-O', 'epiphyses-O', 'has-O', 'now-O', 'been-O', 'reported-O', 'in-O', '11-O', 'infants-O', 'born-O', 'to-O', 'mothers-O', 'treated-O', 'with-O', 'warfarin-B-Chemical']
['Isradipine-B-Chemical', 'treatment-O', 'for-O', 'hypertension-B-Disease', 'in-O', 'general-O', 'practice-O', 'in-O', 'Hong-O', 'Kong-O', '.-O']
['A-O', '6-O', ',-O', 'week-O', 'open-O', 'study-O', 'of-O', 'the-O', 'introduction-O', 'of-O', 'isradipine-B-Chemical', 'treatment-O', 'was-O', 'conducted-O', 'in-O', 'general-O', 'practice-O', 'in-O', 'Hong-O', 'Kong-O', '.-O']
['303-O', 'Chinese-O', 'patients-O', 'with-O', 'mild-O', 'to-O', 'moderate-O', 'hypertension-B-Disease', 'entered-O', 'the-O', 'study-O', '.-O']
['Side-O', 'effects-O', 'were-O', 'reported-O', 'in-O', '21-O', '%-O', 'of-O', 'patients-O', 'and-O', 'caused-O', 'withdrawal-O', 'from-O', 'the-O', 'study-O', 'in-O', '3-O', 'patients-O', '.-O']
['The-O', 'main-O', 'side-O', ',-O', 'effects-O', 'were-O', 'headache-B-Disease', ',-O', 'dizziness-B-Disease', ',-O', 'palpitation-B-Disease', 'and-O', 'flushing-B-Disease', 'and-O', 'these-O', 'were-O', 'not-O', 'more-O', 'frequent-O', 'than-O', 'reported-O', 'in-O', 'other-O', 'studies-O', 'with-O', 'isradipine-B-Chemical', 'or-O', 'with-O', 'placebo-O', '.-O']
['Supine-O', 'blood-O', 'pressure-O', 'was-O', 'reduced-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ')-O', 'from-O', '170-O', '+-O', '20-O', '/-O', '102-O', '+-O', '6-O', 'mmHg-O', 'to-O', '153-O', '+-O', '19-O', '/-O', '92-O', '+-O', '8-O', ',-O', '147-O', '+-O', '18-O', '/-O', '88-O', '+-O', '7-O', 'and-O', '144-O', '+-O', '14-O', '/-O', '87-O', '+-O', '6-O', 'mmHg-O', 'at-O', '2-O', ',-O', '4-O', 'and-O', '6-O', 'weeks-O', 'respectively-O', 'in-O', 'evaluable-O', 'patients-O', '.-O']
['Similar-O', 'reductions-O', 'occurred-O', 'in-O', 'standing-O', 'blood-O', 'pressure-O', 'and-O', 'there-O', 'was-O', 'no-O', 'evidence-O', 'of-O', 'postural-B-Disease', 'hypotension-I-Disease']
['Tachyphylaxis-B-Disease', 'to-O', 'systemic-O', 'but-O', 'not-O', 'to-O', 'airway-O', 'responses-O', 'during-O', 'prolonged-O', 'therapy-O', 'with-O', 'high-O', 'dose-O', 'inhaled-O', 'salbutamol-B-Chemical', 'in-O', 'asthmatics-O', '.-O']
['High-O', 'doses-O', 'of-O', 'inhaled-O', 'salbutamol-B-Chemical', 'produce-O', 'substantial-O', 'improvements-O', 'in-O', 'airway-O', 'response-O', 'in-O', 'patients-O', 'with-O', 'asthma-B-Disease', ',-O', 'and-O', 'are-O', 'associated-O', 'with-O', 'dose-O', ',-O', 'dependent-O', 'systemic-O', 'beta-O', ',-O', 'adrenoceptor-O', 'responses-O', '.-O']
['The-O', 'purpose-O', 'of-O', 'the-O', 'present-O', 'study-O', 'was-O', 'to-O', 'investigate-O', 'whether-O', 'tachyphylaxis-B-Disease', 'occurs-O', 'during-O', 'prolonged-O', 'treatment-O', 'with-O', 'high-O', 'dose-O', 'inhaled-O', 'salbutamol-B-Chemical', '.-O']
['Twelve-O', 'asthmatic-B-Disease', 'patients-O', '(-O', 'FEV1-O', ',-O', '81-O', '+-O', '4-O', '%-O', 'predicted-O', ')-O', 'requiring-O', 'only-O', 'occasional-O', 'inhaled-O', 'beta-O', 'agonists-O', 'as-O', 'their-O', 'sole-O', 'therapy-O', ',-O', 'were-O', 'given-O', 'a-O', '14-O', ',-O', 'day-O', 'treatment-O', 'with-O', 'high-O', 'dose-O', 'inhaled-O', 'salbutamol-B-Chemical', '(-O', 'HDS-O', ')-O', '4-O', ',-O', '000-O', 'micrograms-O', 'daily-O', ',-O', 'low-O', 'dose-O', 'inhaled-O', 'salbutamol-B-Chemical', '(-O', 'LDS-O', ')-O', '800-O', 'micrograms-O', 'daily-O', ',-O', 'or-O', 'placebo-O', '(-O', 'PI-O', ')-O', 'by-O', 'metered-O', ',-O', 'dose-O', 'inhaler-O', 'in-O', 'a-O', 'double-O', ',-O', 'blind-O', ',-O', 'randomized-O', 'crossover-O', 'design-O', '.-O']
['During-O', 'the-O', '14-O', ',-O', 'day-O', 'run-O', ',-O', 'in-O', 'and-O', 'during-O', 'washout-O', 'periods-O', ',-O', 'inhaled-O', 'beta-O', 'agonists-O', 'were-O', 'withheld-O', 'and-O', 'ipratropium-B-Chemical', 'bromide-I-Chemical', 'was-O', 'substituted-O', 'for-O', 'rescue-O', 'purposes-O', '.-O']
['At-O', 'the-O', 'end-O', 'of-O', 'each-O', '14-O', 'day-O', 'treatment-O', ',-O', 'a-O', 'dose-O', ',-O', 'response-O', 'curve-O', '(-O', 'DRC-O', ')-O', 'was-O', 'performed-O', ',-O', 'and-O', 'airway-O', '(-O', 'FEV1-O', ',-O', 'FEF25-O', ',-O', '75-O', ')-O', 'chronotropic-O', '(-O', 'HR-O', ')-O', 'tremor-O', ',-O', 'and-O', 'metabolic-O', '(-O', 'K-O', ',-O', 'Glu-O', ')-O', 'responses-O', 'were-O', 'measured-O', 'at-O', 'each-O', 'step-O', '(-O', 'from-O', '100-O', 'to-O', '4-O', ',-O', '000-O', 'micrograms-O', ')-O', '.-O', 'Treatment-O', 'had-O', 'no-O', 'significant-O', 'effect-O', 'on-O', 'baseline-O', 'values-O', '.-O']
['There-O', 'were-O', 'dose-O', ',-O', 'dependent-O', 'increases-O', 'in-O', 'FEV1-O', 'and-O', 'FEF25-O', ',-O', '75-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'and-O', 'pretreatment-O', 'with-O', 'HDS-B-Chemical', 'did-O', 'not-O', 'displace-O', 'the-O', 'DRC-O', 'to-O', 'the-O', 'right-O', '.-O']
['DRC-O', 'for-O', 'HR-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'K-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'and-O', 'Glu-B-Chemical', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['005-O', ')-O', 'were-O', 'attenuated-O', 'after-O', 'treatment-O', 'with-O', 'HDS-B-Chemical', 'compared-O', 'with-O', 'PI-B-Chemical', '.-O']
['There-O', 'were-O', 'also-O', 'differences-O', 'between-O', 'HDS-O', 'and-O', 'LDS-O', 'for-O', 'HR-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', ')-O', 'and-O', 'Glu-B-Chemical', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ')-O', 'responses-O', '.-O']
['Frequency-O', 'and-O', 'severity-O', 'of-O', 'subjective-O', 'adverse-O', 'effects-O', 'were-O', 'also-O', 'reduced-O', 'after-O', 'HDS-O', ':-O', 'tremor-B-Disease', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', ')-O', 'palpitations-B-Disease']
['Increased-O', 'anxiogenic-O', 'effects-O', 'of-O', 'caffeine-B-Chemical', 'in-O', 'panic-B-Disease', 'disorders-I-Disease', '.-O']
['The-O', 'effects-O', 'of-O', 'oral-O', 'administration-O', 'of-O', 'caffeine-B-Chemical', '(-O', '10-O', 'mg-O', '/-O', 'kg-O', ')-O', 'on-O', 'behavioral-O', 'ratings-O', ',-O', 'somatic-O', 'symptoms-O', ',-O', 'blood-O', 'pressure-O', 'and-O', 'plasma-O', 'levels-O', 'of-O', '3-methoxy-4-hydroxyphenethyleneglycol-B-Chemical', '(-O', 'MHPG-O', ')-O', 'and-O', 'cortisol-B-Chemical', 'were-O', 'determined-O', 'in-O', '17-O', 'healthy-O', 'subjects-O', 'and-O', '21-O', 'patients-O', 'meeting-O', 'DSM-O', ',-O', 'III-O', 'criteria-O', 'for-O', 'agoraphobia-B-Disease', 'with-O', 'panic-B-Disease', 'attacks-O', 'or-O', 'panic-B-Disease', 'disorder-I-Disease', '.-O']
['Caffeine-B-Chemical', 'produced-O', 'significantly-O', 'greater-O', 'increases-O', 'in-O', 'subject-O', ',-O', 'rated-O', 'anxiety-B-Disease', ',-O', 'nervousness-B-Disease', ',-O', 'fear-B-Disease', ',-O', 'nausea-B-Disease', ',-O', 'palpitations-B-Disease', ',-O', 'restlessness-B-Disease', ',-O', 'and-O', 'tremors-B-Disease', 'in-O', 'the-O', 'patients-O', 'compared-O', 'with-O', 'healthy-O', 'subjects-O', '.-O']
['In-O', 'the-O', 'patients-O', ',-O', 'but-O', 'not-O', 'the-O', 'healthy-O', 'subjects-O', ',-O', 'these-O', 'symptoms-B-Disease', 'were-O', 'significantly-O', 'correlated-O', 'with-O', 'plasma-O', 'caffeine-B-Chemical', 'levels-O', '.-O']
['Seventy-O', ',-O', 'one-O', 'percent-O', 'of-O', 'the-O', 'patients-O', 'reported-O', 'that-O', 'the-O', 'behavioral-O', 'effects-O', 'of-O', 'caffeine-B-Chemical', 'were-O', 'similar-O', 'to-O', 'those-O', 'experienced-O', 'during-O', 'panic-B-Disease', 'attacks-O', '.-O']
['Caffeine-B-Chemical', 'did-O', 'not-O', 'alter-O', 'plasma-O', 'MHPG-B-Chemical', 'levels-O', 'in-O', 'either-O', 'the-O', 'healthy-O', 'subjects-O', 'or-O', 'patients-O', '.-O']
['Caffeine-B-Chemical', 'increased-O', 'plasma-O', 'cortisol-B-Chemical', 'levels-O', 'equally-O', 'in-O', 'the-O', 'patient-O', 'and-O', 'healthy-O', 'groups-O', '.-O']
['Because-O', 'caffeine-B-Chemical', 'is-O', 'an-O', 'adenosine-B-Chemical', 'receptor-O', 'antagonist-O', ',-O', 'these-O', 'results-O', 'suggest-O', 'that-O', 'some-O', 'panic-B-Disease', 'disorder-I-Disease', 'patients-O', 'may-O', 'have-O', 'abnormalities-O', 'in-O', 'neuronal-O', 'systems-O', 'involving-O', 'adenosine-B-Chemical', '.-O']
['Patients-O', 'with-O', 'anxiety-B-Disease', 'disorders-I-Disease', 'may-O', 'benefit-O', 'by-O', 'avoiding-O', 'caffeine-B-Chemical']
['Human-O', 'and-O', 'canine-O', 'ventricular-O', 'vasoactive-O', 'intestinal-O', 'polypeptide-O', ':-O', 'decrease-O', 'with-O', 'heart-B-Disease', 'failure-I-Disease', '.-O']
['Vasoactive-O', 'intestinal-O', 'polypeptide-O', '(-O', 'VIP-O', ')-O', 'is-O', 'a-O', 'systemic-O', 'and-O', 'coronary-O', 'vasodilator-O', 'that-O', 'may-O', 'have-O', 'positive-O', 'inotropic-O', 'properties-O', '.-O']
['Myocardial-O', 'levels-O', 'of-O', 'VIP-B-Chemical', 'were-O', 'assayed-O', 'before-O', 'and-O', 'after-O', 'the-O', 'development-O', 'of-O', 'heart-B-Disease', 'failure-I-Disease', 'in-O', 'two-O', 'canine-O', 'models-O', '.-O']
['In-O', 'the-O', 'first-O', ',-O', 'cobalt-O', 'cardiomyopathy-B-Disease', 'was-O', 'induced-O', 'in-O', 'eight-O', 'dogs-O', ';-O', 'VIP-B-Chemical', '(-O', 'by-O', 'radioimmunoassay-O', ')-O', 'decreased-O', 'from-O', '35-O', '+-O', '11-O', 'pg-O', '/-O', 'mg-O', 'protein-O', '(-O', 'mean-O', '+-O', 'SD-O', ')-O', 'to-O', '5-O', '+-O', '4-O', 'pg-O', '/-O', 'mg-O', 'protein-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'In-O', 'six-O', 'dogs-O', 'with-O', 'doxorubicin-B-Chemical', ',-O', 'induced-O', 'heart-B-Disease', 'failure-I-Disease', ',-O', 'VIP-O', 'decreased-O', 'from-O', '31-O', '+-O', '7-O', 'to-O', '11-O', '+-O', '4-O', 'pg-O', '/-O', 'mg-O', 'protein-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'In-O', 'addition-O', ',-O', 'VIP-B-Chemical', 'content-O', 'of-O', 'left-O', 'ventricular-O', 'muscle-O', 'of-O', 'resected-O', 'failing-O', 'hearts-O', 'in-O', '10-O', 'patients-O', 'receiving-O', 'a-O', 'heart-O', 'transplant-O', 'was-O', 'compared-O', 'with-O', 'the-O', 'papillary-O', 'muscles-O', 'in-O', '14-O', 'patients-O', '(-O', 'five-O', 'with-O', 'rheumatic-B-Disease', ',-O', 'nine-O', 'with-O', 'myxomatous-B-Disease', 'degeneration-I-Disease', ')-O', 'receiving-O', 'mitral-O', 'valve-O', 'prostheses-O', '.-O']
['The-O', 'lowest-O', 'myocardial-O', 'VIP-B-Chemical', 'concentration-O', 'was-O', 'found-O', 'in-O', 'the-O', 'hearts-O', 'of-O', 'patients-O', 'with-O', 'coronary-B-Disease', '(-O', 'one-O', 'patient-O', 'receiving-O', 'a-O', 'transplant-O', 'and-O', 'three-O', 'receiving-O', 'mitral-O', 'prostheses-O', ')-O', '(-O', '6-O', '.-O']
['3-O', '+-O', '1-O', '.-O']
['9-O', 'pg-O', '/-O', 'mg-O', 'protein-O', ')-O', '.-O', 'The-O', 'other-O', 'patients-O', 'undergoing-O', 'transplantation-O', 'had-O', 'an-O', 'average-O', 'ejection-O', 'fraction-O', 'of-O', '17-O', '%+-O', '6-O', '%-O', 'and-O', 'a-O', 'VIP-O', 'level-O', 'of-O', '8-O', '.-O']
['8-O', '+-O', '3-O', '.-O']
['9-O', 'pg-O', '/-O', 'mg-O', 'protein-O', '.-O']
['The-O', 'hearts-O', 'without-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease', '(-O', 'average-O', 'ejection-O', 'fraction-O', 'of-O', 'this-O', 'group-O', '62-O', '%+-O', '10-O', ')', 'had-O', 'a-O', 'VIP-B-Chemical', 'concentration-O', 'of-O', '14-O', '.-O']
['1-O', '+-O', '7-O', '.-O']
['9-O', 'pg-O', '/-O', 'mg-O', 'protein-O', ',-O', 'and-O', 'this-O', 'was-O', 'greater-O', 'than-O', 'in-O', 'hearts-O', 'of-O', 'the-O', 'patients-O', 'with-O', 'coronary-B-Disease', 'disease-I-Disease', 'and-O', 'the-O', 'hearts-O', 'of-O', 'patients-O', 'receiving-O', 'a-O', 'transplant-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'Myocardial-O', 'catecholamines-B-Chemical', 'were-O', 'also-O', 'determined-O', 'in-O', '14-O', 'subjects-O', ';-O', 'a-O', 'weak-O', 'correlation-O', '(-O', 'r-O', '=-O', '0-O', '.-O']
['57-O', ',-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ')-O', 'between-O', 'the-O', 'tissue-O', 'concentrations-O', 'of-O', 'VIP-B-Chemical', 'and-O', 'norepinephrine-B-Chemical']
['Interstrain-O', 'variation-O', 'in-O', 'acute-O', 'toxic-O', 'response-O', 'to-O', 'caffeine-B-Chemical', 'among-O', 'inbred-O', 'mice-O', '.-O']
['Acute-O', 'toxic-O', 'dosage-O', ',-O', 'dependent-O', 'behavioral-O', 'effects-O', 'of-O', 'caffeine-B-Chemical', 'were-O', 'compared-O', 'in-O', 'adult-O', 'males-O', 'from-O', 'seven-O', 'inbred-O', 'mouse-O', 'strains-O', '(-O', 'A-O', '/-O', 'J-O', ',-O', 'BALB-O', '/-O', 'cJ-O', ',-O', 'CBA-O', '/-O', 'J-O', ',-O', 'C3H-O', '/-O', 'HeJ-O', ',-O', 'C57BL-O', '/-O', '6J-O', ',-O', 'DBA-O', '/-O', '2J-O', ',-O', 'SWR-O', '/-O', 'J-O', ')-O', '.', 'C57BL-O', '/-O', '6J-O', ',-O', 'chosen-O', 'as-O', 'a-O', 'x-O', 'prototypic-O', 'x-O', 'mouse-O', 'strain-O', ',-O', 'was-O', 'used-O', 'to-O', 'determine-O', 'behavioral-O', 'responses-O', 'to-O', 'a-O', 'broad-O', 'range-O', '(-O', '5-O', ',-O', '500-O', 'mg-O', '/-O', 'kg-O', ')-O', 'of-O', 'caffeine-B-Chemical', 'doses-O', '.-O']
['Five-O', 'phenotypic-O', 'characteristics-O', '--O', 'locomotor-O', 'activity-O', ',-O', 'righting-O', 'ability-O', ',-O', 'clonic-O', 'seizure-B-Disease', 'induction-O', ',-O', 'stress-O', ',-O', 'induced-O', 'lethality-O', ',-O', 'death-O', 'without-O', 'external-O', 'stress-O', '--O', 'were-O', 'scored-O', 'at-O', 'various-O', 'caffeine-B-Chemical', 'doses-O', 'in-O', 'drug-O', ',-O', 'naive-O', 'animals-O', 'under-O', 'empirically-O', 'optimized-O', ',-O', 'rigidly-O', 'constant-O', 'experimental-O', 'conditions-O', '.-O']
['Mice-O', '(-O', 'n-O', '=', '12-O', 'for-O', 'each-O', 'point-O', ')-O', 'received-O', 'single-O', 'IP-O', 'injections-O', 'of-O', 'a-O', 'fixed-O', 'volume-O', '/-O', 'g-O', 'body-O', 'weight-O', 'of-O', 'physiological-O', 'saline-O', 'carrier-O', 'with-O', 'or-O', 'without-O', 'caffeine-B-Chemical', 'in-O', 'doses-O', 'ranging-O', 'from-O', '125-O', ',-O', '500-O', 'mg-O', '/-O', 'kg-O', '.-O']
['Loss-B-Disease', 'of-O', 'righting-O', 'ability-O', 'was-O', 'scored-O', 'at-O', '1-O', ',-O', '3-O', ',-O', '5-O', 'min-O', 'post-O', 'dosing-O', 'and-O', 'at-O', '5-O', 'min-O', 'intervals-O', 'thereafter-O', 'for-O', '20-O', 'min-O', '.-O']
['In-O', 'the-O', 'same-O', 'animals-O', 'the-O', 'occurrence-O', 'of-O', 'clonic-B-Disease', 'seizures-B-Disease', 'was-O', 'scored-O', 'as-O', 'to-O', 'time-O', 'of-O', 'onset-O', 'and-O', 'severity-O', 'for-O', '20-O', 'min-O', 'after-O', 'drug-O', 'administration-O', '.-O']
['When-O', 'these-O', 'proceeded-O', 'to-O', 'tonic-O', 'seizures-B-Disease', ',-O', 'death-B-Disease', 'occurred-O', 'in-O', 'less-O', 'than-O', '20-O', 'min-O', '.-O']
['Animals-O', 'surviving-O', 'for-O', '20-O', 'min-O', 'were-O', 'immediately-O', 'stressed-O', 'by-O', 'a-O', 'swim-O', 'test-O', 'in-O', '25-O', 'degrees-O', 'C-O', 'water-O', ',-O', 'and-O', 'death-B-Disease', ',-O', 'producing-O', 'tonic-O', 'seizures-B-Disease', 'were-O', 'scored-O', 'for-O', '2-O', 'min-O', '.-O']
['In-O', 'other-O', 'animals-O', 'locomotor-O', 'activity-O', 'was-O', 'measured-O', '15-O', 'or-O', '60-O', 'min-O', 'after-O', 'caffeine-B-Chemical', 'administration-O', '.-O']
['By-O', 'any-O', 'single-O', 'behavioral-O', 'criterion-O', 'or-O', 'a-O', 'combination-O', 'of-O', 'these-O', 'criteria-O', ',-O', 'marked-O', 'differences-O', 'in-O', 'response-O', 'to-O', 'toxic-O', 'caffeine-B-Chemical', 'doses-O', 'were-O', 'observed-O', 'between-O', 'strains-O', '.-O']
['These-O', 'results-O', 'indicate-O', 'that-O', 'behavioral-O', 'toxicity-B-Disease', 'testing-O', 'of-O', 'alkylxanthines-B-Chemical']
['Invasive-O', 'carcinoma-B-Disease', 'of-O', 'the-O', 'renal-B-Disease', 'pelvis-I-Disease', 'following-O', 'cyclophosphamide-B-Chemical', 'therapy-O', 'for-O', 'nonmalignant-O', 'disease-O', '.-O']
['A-O', '47-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'with-O', 'right-O', 'hydroureteronephrosis-B-Disease', 'due-O', 'to-O', 'ureterovesical-O', 'junction-O', 'obstruction-B-Disease', 'had-O', 'gross-O', 'hematuria-B-Disease', 'after-O', 'being-O', 'treated-O', 'for-O', 'five-O', 'years-O', 'wtih-O', 'cyclophosphamide-B-Chemical', 'for-O', 'cerebral-B-Disease', 'vasculitis-I-Disease', '.-O']
['A-O', 'right-O', 'nephroureterectomy-B-Disease', 'was-O', 'required-O', 'for-O', 'control-O', 'of-O', 'bleeding-B-Disease', '.-O']
['The-O', 'pathology-O', 'specimen-O', 'contained-O', 'clinically-O', 'occult-B-Disease', 'invasive-B-Disease', 'carcinoma-B-Disease', 'of-O', 'the-O', 'renal-O', 'pelvis-I-Disease', '.-O']
['Although-O', 'the-O', 'ability-O', 'of-O', 'cyclophosphamide-B-Chemical', 'to-O', 'cause-O', 'hemorrhagic-B-Disease', 'cystitis-I-Disease', 'and-O', 'urine-O', 'cytologic-O', 'abnormalities-O', 'indistinguishable-O', 'from-O', 'high-O', 'grade-O', 'carcinoma-B-Disease', 'is-O', 'well-O', 'known-O', ',-O', 'it-O', 'is-O', 'less-O', 'widely-O', 'appreciated-O', 'that-O', 'it-O', 'is-O', 'also-O', 'associated-O', 'with-O', 'carcinoma-B-Disease', 'of-O', 'the-O', 'urinary-O', 'tract-O', '.-O']
['Twenty-O', 'carcinomas-B-Disease', 'of-O', 'the-O', 'urinary-O', 'bladder-I-Disease', 'and-O', 'one-O', 'carcinoma-B-Disease', 'of-O', 'the-O', 'prostate-I-Disease', 'have-O', 'been-O', 'reported-O', 'in-O', 'association-O', 'with-O', 'its-O', 'use-O', '.-O']
['The-O', 'present-O', 'case-O', 'is-O', 'the-O', 'first-O', 'carcinoma-B-Disease', 'of-O', 'the-O', 'renal-O', 'pelvis-I-Disease', 'reported-O', 'in-O', 'association-O', 'with-O', 'cyclophosphamide-B-Chemical', 'treatment-O', '.-O']
['It-O', 'is-O', 'the-O', 'third-O', 'urinary-B-Disease', 'tract-I-Disease', 'cancer-I-Disease', 'reported-O', 'in-O', 'association-O', 'with-O', 'cyclophosphamide-B-Chemical', 'treatment-O', 'for-O', 'nonmalignant-O', 'disease-O', '.-O']
['The-O', 'association-O', 'of-O', 'the-O', 'tumor-B-Disease', 'with-O', 'preexisting-O', 'hydroureteronephrosis-B-Disease', 'suggests-O', 'that-O', 'stasis-O', 'prolonged-O', 'and-O', 'intensified-O', 'exposure-O', 'of-O', 'upper-O', 'urinary-O', 'tract-O', 'epithelium-O', 'to-O', 'cyclophosphamide-B-Chemical', '.-O']
['Patients-O', 'who-O', 'are-O', 'candidates-O', 'for-O', 'long-O', ',-O', 'term-O', 'cyclophosphamide-B-Chemical', 'treatment-O', 'should-O', 'be-O', 'routinely-O', 'evaluated-O', 'for-O', 'obstructive-O', 'uropathy-B-Disease']
['Ascending-O', 'dose-O', 'tolerance-O', 'study-O', 'of-O', 'intramuscular-O', 'carbetocin-B-Chemical', 'administered-O', 'after-O', 'normal-O', 'vaginal-O', 'birth-O', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'determine-O', 'the-O', 'maximum-O', 'tolerated-O', 'dose-O', '(-O', 'MTD-O', ')-O', 'of-O', 'carbetocin-B-Chemical', '(-O', 'a-O', 'long-O', ',-O', 'acting-O', 'synthetic-O', 'analogue-O', 'of-O', 'oxytocin-B-Chemical', ')-O', ',', 'when-O', 'administered-O', 'immediately-O', 'after-O', 'vaginal-O', 'delivery-O', 'at-O', 'term-O', '.-O']
['MATERIALS-O', 'AND-O', 'METHODS-O', ':-O', 'Carbetocin-B-Chemical', 'was-O', 'given-O', 'as-O', 'an-O', 'intramuscular-O', 'injection-O', 'immediately-O', 'after-O', 'the-O', 'birth-O', 'of-O', 'the-O', 'infant-O', 'in-O', '45-O', 'healthy-O', 'women-O', 'with-O', 'normal-O', 'singleton-O', 'pregnancies-O', 'who-O', 'delivered-O', 'vaginally-O', 'at-O', 'term-O', '.-O']
['Dosage-O', 'groups-O', 'of-O', '15-O', ',-O', '30-O', ',-O', '50-O', ',-O', '75-O', ',-O', '100-O', ',-O', '125-O', ',-O', '150-O', ',-O', '175-O', 'or-O', '200-O', 'microg-O', 'carbetocin-Chemical', 'were-O', 'assigned-O', 'to-O', 'blocks-O', 'of-O', 'three-O', 'women-O', 'according-O', 'to-O', 'the-O', 'continual-O', 'reassessment-O', 'method-O', '(-O', 'CRM-O', ').-O', 'RESULTS-O', ':-O', 'All-O', 'dosage-O', 'groups-O', 'consisted-O', 'of-O', 'three-O', 'women-O', ',-O', 'except-O', 'those-O', 'with-O', '100-O', 'microg-O', '(-O', 'n-O', '=', '6-O', ')-O', 'and-O', '200-O', 'microg-O', '(-O', 'n-O', '=', '18-O', ').-O', 'Recorded-O', 'were-O', 'dose-O', ',-O', 'limiting-O', 'adverse-O', 'events-O', ':-O', 'hyper--O', 'or-O', 'hypotension-Disease', '(-O', 'three-O', ')-O', ',', 'severe-O', 'abdominal-O', 'pain-Disease', '(-O', '0-O', ')-O', ',', 'vomiting-Disease', '(-O', '0-O', ')-O', 'and-O', 'retained-O', 'placenta-Disease', '(-O', 'four-O', ').-O', 'Serious-O', 'adverse-O', 'events-O', 'occurred-O', 'in-O', 'seven-O', 'women-O', ':-O', 'six-O', 'cases-O', 'with-O', 'blood-O', 'loss-Disease', '>-O', 'or-O', '='-O', '1000-O', 'ml-O', ',-O', 'four-O', 'cases-O', 'of-O', 'manual-O', 'placenta-O', 'removal-O', ',-O', 'five-O', 'cases-O', 'of-O', 'additional-O', 'oxytocics-O', 'administration-O', 'and-O', 'five-O', 'cases-O', 'of-O', 'blood-O', 'transfusion-O', '.-O']
['Maximum-O', 'blood-O', 'loss-O', 'was-O', 'greatest-O', 'at-O', 'the-O', 'upper-O', 'and-O', 'lower-O', 'dose-O', 'levels-O', ',-O', 'and-O', 'lowest-O', 'in-O', 'the-O', '70-O', ',-O', '125-O', 'microg-O', 'dose-O', 'range-O', '.-O']
['Four-O', 'out-O', 'of-O', 'six-O', 'cases-O', 'with-O', 'blood-O', 'loss-B-Disease', '>-O', 'or-O', '=-O', '1000-O', 'ml-O', 'occurred-O', 'in-O', 'the-O', '200-O', 'microg-O', 'group-O', '.-O']
['The-O', 'majority-O', 'of-O', 'additional-O', 'administration-O', 'of-O', 'oxytocics-B-Chemical', '(-O', '4-O', '/-O', '5-O', ')-O', 'and-O', 'blood-O', 'transfusion-O', '(-O', '3-O', '/-O', '5-O', ')-O', 'occurred-O', 'in-O', 'the-O', 'dose-O', 'groups-O', 'of-O', '200-O', 'microg-O', '.-O']
['All-O', 'retained-O', 'placentae-O', 'were-O', 'found-O', 'in-O', 'the-O', 'group-O', 'of-O', '200-O', 'microg-O', '.-O']
['CONCLUSION-O', ':-O', 'The-O', 'MTD-O', 'was-O', 'calculated-O', 'to-O', 'be-O', 'at-O', '200-O', 'microg-O', 'carbetocin-B-Chemical']
['A-O', 'pilot-O', 'study-O', 'to-O', 'assess-O', 'the-O', 'safety-O', 'of-O', 'dobutamine-B-Chemical', 'stress-O', 'echocardiography-O', 'in-O', 'the-O', 'emergency-O', 'department-O', 'evaluation-O', 'of-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', '.-O']
['STUDY-O', 'OBJECTIVE-O', ':-O', 'Chest-B-Disease', 'pain-I-Disease', 'in-O', 'the-O', 'setting-O', 'of-O', 'cocaine-B-Chemical', 'use-O', 'poses-O', 'a-O', 'diagnostic-O', 'dilemma-O', '.-O']
['Dobutamine-B-Chemical', 'stress-O', 'echocardiography-O', '(-O', 'DSE-O', ')-O', 'is-O', 'a-O', 'widely-O', 'available-O', 'and-O', 'sensitive-O', 'test-O', 'for-O', 'evaluating-O', 'cardiac-B-Disease', 'ischemia-I-Disease', '.-O']
['Because-O', 'of-O', 'the-O', 'theoretical-O', 'concern-O', 'regarding-O', 'administration-O', 'of-O', 'dobutamine-B-Chemical', 'in-O', 'the-O', 'setting-O', 'of-O', 'cocaine-B-Chemical', 'use-O', ',-O', 'we-O', 'conducted-O', 'a-O', 'pilot-O', 'study-O', 'to-O', 'assess-O', 'the-O', 'safety-O', 'of-O', 'DSE-O', 'in-O', 'emergency-O', 'department-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', '.-O']
['METHODS-O', ':-O', 'A-O', 'prospective-O', 'case-O', 'series-O', 'was-O', 'conducted-O', 'in-O', 'the-O', 'intensive-O', 'diagnostic-O', 'and-O', 'treatment-O', 'unit-O', 'in-O', 'the-O', 'ED-O', 'of-O', 'an-O', 'urban-O', 'tertiary-O', ',-O', 'care-O', 'teaching-O', 'hospital-O', '.-O']
['Patients-O', 'were-O', 'eligible-O', 'for-O', 'DSE-O', 'if-O', 'they-O', 'had-O', 'used-O', 'cocaine-B-Chemical', 'within-O', '24-O', 'hours-O', 'preceding-O', 'the-O', 'onset-O', 'of-O', 'chest-B-Disease', 'pain-I-Disease', 'and-O', 'had-O', 'a-O', 'normal-O', 'ECG-O', 'and-O', 'tropinin-O', 'I-O', 'level-O', '.-O']
['Patients-O', 'exhibiting-O', 'signs-O', 'of-O', 'continuing-O', 'cocaine-B-Chemical', 'toxicity-B-Disease', 'were-O', 'excluded-O', 'from-O', 'the-O', 'study-O', '.-O']
['All-O', 'patients-O', 'were-O', 'admitted-O', 'to-O', 'the-O', 'hospital-O', 'for-O', 'serial-O', 'testing-O', 'after-O', 'the-O', 'DSE-O', 'testing-O', 'in-O', 'the-O', 'intensive-O', 'diagnostic-O', 'and-O', 'treatment-O', 'unit-O', '.-O']
['RESULTS-O', ':-O', 'Twenty-O', ',-O', 'four-O', 'patients-O', 'were-O', 'enrolled-O', '.-O']
['Two-O', 'patients-O', 'had-O', 'inadequate-O', 'resting-O', 'images-O', ',-O', 'one-O', 'DSE-O', 'was-O', 'terminated-O', 'because-O', 'of-O', 'inferior-O', 'hypokinesis-B-Disease', ',-O', 'another-O', 'DSE-O', 'was-O', 'terminated-O', 'because-O', 'of-O', 'a-O', 'rate-O', 'related-O', 'atrial-O', 'conduction-O', 'deficit-B-Disease', ',-O', 'and-O', '1-O', 'patient-O', 'did-O', 'not-O', 'reach-O', 'the-O', 'target-O', 'heart-O', 'rate-O', '.-O']
['Thus-O', ',-O', '19-O', 'patients-O', 'completed-O', 'a-O', 'DSE-O', 'and-O', 'reached-O', 'their-O', 'target-O', 'heart-O', 'rates-O', '.-O']
['of-O', 'the-O', 'patients-O', 'experienced-O', 'signs-O', 'of-O', 'exaggerated-O', 'adrenergic-O', 'response-O', ',-O', 'which-O', 'was-O', 'defined-O', 'as-O', 'a-O', 'systolic-O', 'blood-O', 'pressure-O', 'of-O', 'greater-O', 'than-O', '200-O', 'mm-O', 'Hg-O', 'or-O', 'the-O', 'occurrence-O', 'of-O', 'tachydysrhythmias-O', '(-O', 'excluding-O', 'sinus-O', 'tachycardia-O', ').-O', 'Further-O', 'suggesting-O', 'lack-O', 'of-O', 'exaggerated-O', 'adrenergic-O', 'response-O', ',-O', '13-O', '(-O', '65-O', ')-O', 'of-O', '20-O', 'patients-O', 'required-O', 'supplemental-O', 'atropine-B-Chemical', 'to-O', 'reach-O', 'their-O', 'target-O', 'heart-O', 'rates-O', '.-O']
['CONCLUSION-O', ':-O', 'No-O', 'exaggerated-O', 'adrenergic-O', 'response-O', 'was-O', 'detected-O', 'when-O', 'dobutamine-B-Chemical', 'was-O', 'administered-O', 'to-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'related-O', 'chest-B-Disease', 'pain-I-Disease']
['Amiodarone-B-Chemical', ',-O', 'induced-O', 'torsade-B-Disease', 'de-I-Disease', 'pointes-I-Disease', 'during-O', 'bladder-O', 'irrigation-O', ':-O', 'an-O', 'unusual-O', 'presentation-O', '--O', 'a-O', 'case-O', 'report-O', '.-O']
['The-O', 'authors-O', 'present-O', 'a-O', 'case-O', 'of-O', 'early-O', '(-O', 'within-O', '4-O', 'days-O', ')-O', 'development-O', 'of-O', 'torsade-B-Disease', 'de-I-Disease', 'pointes-I-Disease', '(-O', 'TdP-B-Disease', ')-O', 'associated-O', 'with-O', 'oral-O', 'amiodarone-B-Chemical', 'therapy-O', '.-O']
['Consistent-O', 'with-O', 'other-O', 'reports-O', 'this-O', 'case-O', 'of-O', 'TdP-B-Disease', 'occurred-O', 'in-O', 'the-O', 'context-O', 'of-O', 'multiple-O', 'exacerbating-O', 'factors-O', 'including-O', 'hypokalemia-B-Disease', 'and-O', 'digoxin-B-Chemical', 'excess-O', '.-O']
['Transient-O', 'prolongation-O', 'of-O', 'the-O', 'QT-O', 'during-O', 'bladder-O', 'irrigation-O', 'prompted-O', 'the-O', 'episode-O', 'of-O', 'TdP-B-Disease', '.-O']
['It-O', 'is-O', 'well-O', 'known-O', 'that-O', 'bradycardia-B-Disease', 'exacerbates-O', 'acquired-O', 'TdP-B-Disease', '.-O']
['The-O', 'authors-O', 'speculate-O', 'that-O', 'the-O', 'increased-O', 'vagal-O', 'tone-O', 'during-O', 'bladder-O', 'irrigation-O', ',-O', 'a-O', 'vagal-O', 'maneuver-O', ',-O', 'in-O', 'the-O', 'context-O', 'of-O', 'amiodarone-B-Chemical', 'therapy-O', 'resulted-O', 'in-O', 'amiodarone-B-Chemical', ',-O', 'induced-O', 'proarrhythmia-B-Disease', '.-O']
['In-O', 'the-O', 'absence-O', 'of-O', 'amiodarone-B-Chemical', 'therapy-O', ',-O', 'a-O', 'second-O', 'bladder-O', 'irrigation-O', 'did-O', 'not-O', 'induce-O', 'TdP-B-Disease', 'despite-O', 'hypokalemia-B-Disease', 'and-O', 'hypomagnesemia-B-Disease']
['Acute-O', 'renal-B-Disease', 'insufficiency-I-Disease', 'after-O', 'high-O', ',-O', 'dose-O', 'melphalan-B-Chemical', 'in-O', 'patients-O', 'with-O', 'primary-O', 'systemic-O', 'amyloidosis-B-Disease', 'during-O', 'stem-O', 'cell-O', 'transplantation-O', '.-O']
['BACKGROUND-O', ':-O', 'Patients-O', 'with-O', 'primary-B-Disease', 'systemic-O', 'amyloidosis-I-Disease', '(-O', 'AL-O', ')-O', 'have-O', 'a-O', 'poor-O', 'prognosis-O', '.-O']
['Median-O', 'survival-O', 'time-O', 'from-O', 'standard-O', 'treatments-O', 'is-O', 'only-O', '17-O', 'months-O', '.-O']
['High-O', ',-O', 'dose-O', 'intravenous-O', 'melphalan-B-Chemical', 'followed-O', 'by-O', 'peripheral-O', 'blood-O', 'stem-O', 'cell-O', 'transplant-O', '(-O', 'PBSCT-O', ')', 'appears-O', 'to-O', 'be-O', 'the-O', 'most-O', 'promising-O', 'therapy-O', ',-O', 'but-O', 'treatment-O', 'mortality-O', 'can-O', 'be-O', 'high-O', '.-O']
['The-O', 'authors-O', 'have-O', 'noted-O', 'the-O', 'development-O', 'of-O', 'acute-B-Disease', 'renal-B-Disease', 'insufficiency-I-Disease', 'immediately-O', 'after-O', 'melphalan-B-Chemical', 'conditioning-O', '.-O']
['This-O', 'study-O', 'was-O', 'undertaken-O', 'to-O', 'further-O', 'examine-O', 'its-O', 'risk-O', 'factors-O', 'and-O', 'impact-O', 'on-O', 'posttransplant-O', 'mortality-O', '.-O']
['METHODS-O', ':-O', 'Consecutive-O', 'AL-B-Disease', 'patients-O', 'who-O', 'underwent-O', 'PBSCT-O', 'were-O', 'studied-O', 'retrospectively-O', '.-O']
['Acute-O', 'renal-B-Disease', 'insufficiency-I-Disease', '(-O', 'ARI-O', ')', 'after-O', 'high-O', ',-O', 'dose-O', 'melphalan-B-Chemical', 'was-O', 'defined-O', 'by-O', 'a-O', 'minimum-O', 'increase-O', 'of-O', '0-O', '.-O']
['5-O', 'mg-O', '/-O', 'dL-O', '(-O', '44-O', 'micromol-O', '/-O', 'L-O', ')-O', 'in-O', 'the-O', 'serum-O', 'creatinine-B-Chemical', 'level-O', 'that-O', 'is-O', 'greater-O', 'than-O', '50-O', '%-O', 'of-O', 'baseline-O', 'immediately-O', 'after-O', 'conditioning-O', '.-O']
['Urine-O', 'sediment-O', 'score-O', 'was-O', 'the-O', 'sum-O', 'of-O', 'the-O', 'individual-O', 'types-O', 'of-O', 'sediment-O', 'identified-O', 'on-O', 'urine-O', 'microscopy-O', '.-O']
['RESULTS-O', ':-O', 'Of-O', 'the-O', '80-O', 'patients-O', 'studied-O', ',-O', 'ARI-B-Disease', 'developed-O', 'in-O', '18-O', '.-O']
['8-O', '%-O', 'of-O', 'the-O', 'patients-O', 'after-O', 'high-O', ',-O', 'dose-O', 'melphalan-B-Chemical', '.-O']
['Univariate-O', 'analysis-O', 'identified-O', 'age-O', ',-O', 'hypoalbuminemia-B-Disease', ',-O', 'heavy-O', 'proteinuria-B-Disease', ',-O', 'diuretic-B-Chemical', 'use-O', ',-O', 'and-O', 'urine-O', 'sediment-O', 'score-O', '(>-O', '3-O', ')', 'as-O', 'risk-O', 'factors-O', '.-O']
['Age-O', 'and-O', 'urine-O', 'sediment-O', 'score-O', 'remained-O', 'independently-O', 'significant-O', 'risk-O', 'factors-O', 'in-O', 'the-O', 'multivariate-O', 'analysis-O', '.-O']
['Patients-O', 'who-O', 'had-O', 'ARI-B-Disease', 'after-O', 'high-O', ',-O', 'dose-O', 'melphalan-B-Chemical', 'underwent-O', 'dialysis-O', 'more-O', 'often-O', '(-O', 'P-O', '=', '0-O', '.-O']
['007-O', ')-O', 'and-O', 'had-O', 'a-O', 'worse-O', '1-O', '-O', 'year-O', 'survival-O', '(-O', 'P-O', '=O', '0-O', '.-O']
['03-O', ').-O', 'CONCLUSION-O', ':-O', 'The-O', 'timing-O', 'of-O', 'renal-B-Disease', 'injury-I-Disease', 'strongly-O', 'suggests-O', 'melphalan-B-Chemical', 'as-O', 'the-O', 'causative-O', 'agent-O', '.-O']
['Ongoing-O', 'tubular-O', 'injury-O', 'may-O', 'be-O', 'a-O', 'prerequisite-O', 'for-O', 'renal-O', 'injury-O', 'by-O', 'melphalan-B-Chemical', 'as-O', 'evidenced-O', 'by-O', 'the-O', 'active-O', 'urinary-O', 'sediment-O', '.-O']
['Development-O', 'of-O', 'ARI-B-Disease', 'adversely-O', 'affected-O', 'the-O', 'outcome-O', 'after-O', 'PBSCT-O', '.-O']
['Effective-O', 'preventive-O', 'measures-O', 'may-O', 'help-O', 'decrease-O', 'the-O', 'treatment-O', 'mortality-O', 'of-O', 'PBSCT-O', 'in-O', 'AL-B-Disease']
['Impaired-B-Disease', 'fear-O', 'recognition-O', 'in-O', 'regular-O', 'recreational-O', 'cocaine-B-Chemical', 'users-O', '.-O']
['INTRODUCTION-O', ':-O', 'The-O', 'ability-O', 'to-O', 'read-O', 'facial-O', 'expressions-O', 'is-O', 'essential-O', 'for-O', 'normal-O', 'human-O', 'social-O', 'interaction-O', '.-O']
['The-O', 'aim-O', 'of-O', 'the-O', 'present-O', 'study-O', 'was-O', 'to-O', 'conduct-O', 'the-O', 'first-O', 'investigation-O', 'of-O', 'facial-O', 'expression-O', 'recognition-O', 'performance-O', 'in-O', 'recreational-O', 'cocaine-B-Chemical', 'users-O', '.-O']
['MATERIALS-O', 'AND-O', 'METHODS-O', ':-O', 'Three-O', 'groups-O', ',-O', 'comprised-O', 'of-O', '21-O', 'cocaine-B-Chemical', 'naive-O', 'participants-O', '(-O', 'CN-O', ')-O', ',-', '30-O', 'occasional-O', 'cocaine-B-Chemical', '(-O', 'OC-O', ')-O', ',-', 'and-O', '48-O', 'regular-O', 'recreational-O', 'cocaine-B-Chemical', '(-O', 'RC-O', ')-O', 'users-O', ',-O', 'were-O', 'compared-O', '.-O']
['An-O', 'emotional-O', 'facial-O', 'expression-O', '(-O', 'EFE-O', ')-O', 'task-O', 'consisting-O', 'of-O', 'a-O', 'male-O', 'and-O', 'female-O', 'face-O', 'expressing-O', 'six-O', 'basic-O', 'emotions-O', '(-O', 'happiness-O', ',-O', 'surprise-O', ',-O', 'sadness-O', ',-O', 'anger-O', ',-O', 'fear-O', ',-O', 'and-O', 'disgust-O', ')-O', 'was-O', 'administered-O', '.-O']
['Mean-O', 'percent-O', 'accuracy-O', 'and-O', 'latencies-O', 'for-O', 'correct-O', 'responses-O', 'across-O', 'eight-O', 'presentations-O', 'of-O', 'each-O', 'basic-O', 'emotion-O', 'were-O', 'derived-O', '.-O']
['Participants-O', 'were-O', 'also-O', 'assessed-O', 'with-O', 'the-O', 'x-O', 'Eyes-O', 'task-O', 'x-O', 'to-O', 'investigate-O', 'their-O', 'ability-O', 'to-O', 'recognize-O', 'more-O', 'complex-O', 'emotional-O', 'states-O', 'and-O', 'the-O', 'Symptom-O', 'CheckList-O', ',-O', '90-O', ',-O', 'Revised-O', 'to-O', 'measure-O', 'psychopathology-B-Disease', '.-O']
['RESULTS-O', ':-O', 'There-O', 'were-O', 'no-O', 'group-O', 'differences-O', 'in-O', 'psychopathology-O', 'or-O', 'x-O', 'eyes-O', 'task-O', 'x-O', 'performance-O', ',-O', 'but-O', 'the-O', 'RC-O', 'group-O', ',-O', 'who-O', 'otherwise-O', 'had-O', 'similar-O', 'illicit-O', 'substance-O', 'use-O', 'histories-O', 'to-O', 'the-O', 'OC-O', 'group-O', ',-O', 'exhibited-O', 'impaired-O', 'fear-O', 'recognition-O', 'accuracy-O', 'compared-O', 'to-O', 'the-O', 'OC-O', 'and-O', 'CN-O', 'groups-O', '.-O']
['The-O', 'RC-O', 'group-O', 'also-O', 'correctly-O', 'identified-O', 'anger-O', ',-O', 'fear-O', ',-O', 'happiness-O', ',-O', 'and-O', 'surprise-O', ',-O', 'more-O', 'slowly-O', 'than-O', 'CN-O', ',-O', 'but-O', 'not-O', 'OC-B-Chemical', 'participants-O', '.-O']
['The-O', 'OC-B-Chemical', 'group-O', 'was-O', 'slower-O', 'than-O', 'CN-O', 'when-O', 'correctly-O', 'identifying-O', 'disgust-O', '.-O']
['The-O', 'selective-O', 'deficit-O', 'in-O', 'fear-O', 'recognition-O', 'accuracy-O', 'manifested-O', 'by-O', 'the-O', 'RC-O', 'group-O', 'cannot-O', 'be-O', 'explained-O', 'by-O', 'the-O', 'subacute-O', 'effects-O', 'of-O', 'cocaine-B-Chemical', ',-O', 'or-O', 'ecstasy-B-Chemical', ',-O', 'because-O', 'recent-O', 'and-O', 'less-O', 'recent-O', 'users-O', 'of-O', 'these-O', 'drugs-O', 'within-O', 'this-O', 'group-O', 'were-O', 'similarly-O', 'impaired-O', '.-O']
['Possible-O', 'parallels-O', 'between-O', 'RC-O', 'users-O', 'and-O', 'psychopaths-O', 'with-O', 'respect-O', 'to-O', 'impaired-O', 'fear-O', 'recognition-O', ',-O', 'amygdala-B-Disease', 'dysfunction-I-Disease']
['Corneal-B-Disease', 'ulcers-I-Disease', 'associated-O', 'with-O', 'aerosolized-O', 'crack-O', 'cocaine-B-Chemical', 'use-O', '.-O']
['PURPOSE-O', ':-O', 'We-O', 'report-O', '4-O', 'cases-O', 'of-O', 'corneal-B-Disease', 'ulcers-I-Disease', 'associated-O', 'with-O', 'drug-O', 'abuse-I-Disease', '.-O']
['The-O', 'pathogenesis-O', 'of-O', 'these-O', 'ulcers-B-Disease', 'and-O', 'management-O', 'of-O', 'these-O', 'patients-O', 'are-O', 'also-O', 'reviewed-O', '.-O']
['METHODS-O', ':-O', 'Review-O', 'of-O', 'all-O', 'cases-O', 'of-O', 'corneal-B-Disease', 'ulcers-I-Disease', 'associated-O', 'with-O', 'drug-B-Disease', 'abuse-I-Disease', 'seen-O', 'at-O', 'our-O', 'institution-O', 'from-O', 'July-O', '2006-O', 'to-O', 'December-O', '2006-O', '.-O']
['RESULTS-O', ':-O', 'Four-O', 'patients-O', 'with-O', 'corneal-O', 'ulcers-B-Disease', 'associated-O', 'with-O', 'crack-O', 'cocaine-B-Chemical', 'use-O', 'were-O', 'reviewed-O', '.-O']
['All-O', 'corneal-B-Disease', 'ulcers-I-Disease', 'were-O', 'cultured-O', ',-O', 'and-O', 'the-O', 'patients-O', 'were-O', 'admitted-O', 'to-O', 'the-O', 'hospital-O', 'for-O', 'intensive-O', 'topical-O', 'antibiotic-O', 'treatment-O', '.-O']
['Each-O', 'patient-O', 'received-O', 'comprehensive-O', 'health-O', 'care-O', ',-O', 'including-O', 'medical-O', 'and-O', 'substance-B-Disease', 'abuse-I-Disease', 'consultations-O', '.-O']
['Streptococcal-B-Disease', 'organisms-O', 'were-O', 'found-O', 'in-O', '3-O', 'cases-O', 'and-O', 'Capnocytophaga-B-Disease', 'and-O', 'Brevibacterium-B-Disease', 'casei-O', 'in-O', '1-O', 'patient-O', '.-O']
['The-O', 'infections-B-Disease', 'responded-O', 'to-O', 'antibiotic-O', 'treatment-O', '.-O']
['Two-O', 'patients-O', 'needed-O', 'a-O', 'lateral-O', 'tarsorrhaphy-O', 'for-O', 'persistent-O', 'epithelial-O', 'defects-I-Disease', '.-O']
['CONCLUSIONS-O', ':-O', 'Aerosolized-O', 'crack-B-Chemical', 'cocaine-B-Chemical', 'use-O', 'can-O', 'be-O', 'associated-O', 'with-O', 'the-O', 'development-O', 'of-O', 'corneal-B-Disease', 'ulcers-I-Disease', '.-O']
['Drug-B-Disease', 'abuse-I-Disease', 'provides-O', 'additional-O', 'challenges-O', 'for-O', 'management-O', '.-O']
['Not-O', 'only-O', 'treatment-O', 'of-O', 'their-O', 'infections-B-Disease', 'but-O', 'also-O', 'the-O', 'overall-O', 'poor-O', 'health-O', 'of-O', 'the-O', 'patients-O', 'and-O', 'increased-O', 'risk-O', 'of-O', 'noncompliance-O', 'need-O', 'to-O', 'be-O', 'addressed-O', '.-O']
['Comprehensive-O', 'care-O', 'may-O', 'provide-O', 'the-O', 'patient-O', 'the-O', 'opportunity-O', 'to-O', 'discontinue-O', 'their-O', 'substance-B-Disease', 'abuse-I-Disease']
['Levetiracetam-B-Chemical', 'as-O', 'an-O', 'adjunct-O', 'to-O', 'phenobarbital-B-Chemical', 'treatment-O', 'in-O', 'cats-O', 'with-O', 'suspected-O', 'idiopathic-B-Disease', 'epilepsy-I-Disease', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'assess-O', 'pharmacokinetics-O', ',-O', 'efficacy-O', ',-O', 'and-O', 'tolerability-O', 'of-O', 'oral-O', 'levetiracetam-B-Chemical', 'administered-O', 'as-O', 'an-O', 'adjunct-O', 'to-O', 'phenobarbital-B-Chemical', 'treatment-O', 'in-O', 'cats-O', 'with-O', 'poorly-O', 'controlled-O', 'suspected-O', 'idiopathic-O', 'epilepsy-B-Disease', '.-O']
['DESIGN-O', ',-O', 'Open-O', ',-O', 'label-O', ',-O', 'noncomparative-O', 'clinical-O', 'trial-O', '.-O']
['ANIMALS-O', ':-O', '12-O', 'cats-O', 'suspected-O', 'to-O', 'have-O', 'idiopathic-B-Disease', 'epilepsy-B-Disease', 'that-O', 'was-O', 'poorly-O', 'controlled-O', 'with-O', 'phenobarbital-B-Chemical', 'or-O', 'that-O', 'had-O', 'unacceptable-O', 'adverse-O', 'effects-O', 'when-O', 'treated-O', 'with-O', 'phenobarbital-B-Chemical', '.-O']
['PROCEDURES-O', ':-O', 'Cats-O', 'were-O', 'treated-O', 'with-O', 'levetiracetam-B-Chemical', '(-O', '20-O', 'mg-O', '/-O', 'kg-O', '[-O', '9-O', '.-O']
['1-O', 'mg-O', '/-O', 'lb-O', ']-O', ',-O', 'PO-O', ',-O', 'q-O', '8-O', 'h-O', ').-O', 'After-O', 'a-O', 'minimum-O', 'of-O', '1-O', 'week-O', 'of-O', 'treatment-O', ',-O', 'serum-O', 'levetiracetam-B-Chemical', 'concentrations-O', 'were-O', 'measured-O', 'before-O', 'and-O', '2-O', ',-O', '4-O', ',-O', 'and-O', '6-O', 'hours-O', 'after-O', 'drug-O', 'administration-O', ',-O', 'and-O', 'maximum-O', 'and-O', 'minimum-O', 'serum-O', 'concentrations-O', 'and-O', 'elimination-O', 'half-O', ',-O', 'life-O', 'were-O', 'calculated-O', '.-O']
['Seizure-B-Disease', 'frequencies-O', 'before-O', 'and-O', 'after-O', 'initiation-O', 'of-O', 'levetiracetam-B-Chemical', 'treatment-O', 'were-O', 'compared-O', ',-O', 'and-O', 'adverse-O', 'effects-O', 'were-O', 'recorded-O', '.-O']
['RESULTS-O', ':-O', 'Median-O', 'maximum-O', 'serum-O', 'levetiracetam-B-Chemical', 'concentration-O', 'was-O', '25-O', '.-O']
['5-O', 'microg-O', '/-O', 'mL-O', ',-O', 'median-O', 'minimum-O', 'serum-O', 'levetiracetam-B-Chemical', 'concentration-O', 'was-O', '8-O', '.-O']
['3-O', 'microg-O', '/-O', 'mL-O', ',-O', 'and-O', 'median-O', 'elimination-O', 'half-O', ',-O', 'life-O', 'was-O', '2-O', '.-O']
['9-O', 'hours-O', '.-O']
['Median-O', 'seizure-B-Disease', 'frequency-O', 'prior-O', 'to-O', 'treatment-O', 'with-O', 'levetiracetam-B-Chemical', '(-O', '2-O', '.-O']
['1-O', 'seizures-O', '/-O', 'mo-O', ')-O', 'was-O', 'significantly-O', 'higher-O', 'than-O', 'median-O', 'seizure-B-Disease', 'frequency-O', 'after-O', 'initiation-O', 'of-O', 'levetiracetam-B-Chemical', 'treatment-O', '(-O', '0-O', '.-O']
['42-O', 'seizures-O', '/-O', 'mo-O', '),-O', 'and-O', '7-O', 'of-O', '10-O', 'cats-O', 'were-O', 'classified-O', 'as-O', 'having-O', 'responded-O', 'to-O', 'levetiracetam-B-Chemical', 'treatment-O', '(-O', 'ie-O', ',-O', 'reduction-O', 'in-O', 'seizure-B-Disease', 'frequency-O', 'of-O', '>-O', 'or-O', '=-O', '50-O', ').-O', 'Two-O', 'cats-O', 'had-O', 'transient-O', 'lethargy-B-Disease', 'and-O', 'inappetence-B-Disease', '.-O']
['CONCLUSIONS-O', 'AND-O', 'CLINICAL-O', 'RELEVANCE-O', ':-O', 'Results-O', 'suggested-O', 'that-O', 'levetiracetam-B-Chemical', 'is-O', 'well-O', 'tolerated-O', 'in-O', 'cats-O', 'and-O', 'may-O', 'be-O', 'useful-O', 'as-O', 'an-O', 'adjunct-O', 'to-O', 'phenobarbital-B-Chemical', 'treatment-O', 'in-O', 'cats-O', 'with-O', 'idiopathic-B-Disease', 'epilepsy-I-Disease']
['Bilateral-O', 'haemorrhagic-O', 'infarction-I-Disease', 'of-O', 'the-O', 'globus-O', 'pallidus-O', 'after-O', 'cocaine-B-Chemical', 'and-O', 'alcohol-B-Chemical', 'intoxication-O', '.-O']
['Cocaine-B-Chemical', 'is-O', 'a-O', 'risk-O', 'factor-O', 'for-O', 'both-O', 'ischemic-B-Disease', 'and-O', 'haemorrhagic-B-Disease', 'stroke-B-Disease', '.-O']
['We-O', 'present-O', 'the-O', 'case-O', 'of-O', 'a-O', '31-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'with-O', 'bilateral-O', 'ischemia-O', 'of-O', 'the-O', 'globus-O', 'pallidus-O', 'after-O', 'excessive-O', 'alcohol-B-Chemical', 'and-O', 'intranasal-O', 'cocaine-B-Chemical', 'use-O', '.-O']
['Drug-O', ',-O', 'related-O', 'globus-O', 'pallidus-O', 'infarctions-O', 'are-O', 'most-O', 'often-O', 'associated-O', 'with-O', 'heroin-B-Chemical', '.-O']
['Bilateral-O', 'basal-O', 'ganglia-O', 'infarcts-B-Disease', 'after-O', 'the-O', 'use-O', 'of-O', 'cocaine-B-Chemical', ',-O', 'without-O', 'concurrent-O', 'heroin-B-Chemical', 'use-O', ',-O', 'have-O', 'never-O', 'been-O', 'reported-O', '.-O']
['In-O', 'our-O', 'patient-O', ',-O', 'transient-O', 'cardiac-B-Disease', 'arrhythmia-I-Disease', 'or-O', 'respiratory-B-Disease', 'dysfunction-I-Disease', 'related-O', 'to-O', 'cocaine-B-Chemical', 'and-O', '/-O', 'or-O', 'ethanol-B-Chemical', 'use-O', 'were-O', 'the-O', 'most-O', 'likely-O', 'causes-O', 'of-O', 'cerebral-B-Disease', 'hypoperfusion-I-Disease']
['Acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'after-O', 'high-O', ',-O', 'dose-O', 'methotrexate-B-Chemical', 'therapy-O', 'in-O', 'a-O', 'patient-O', 'with-O', 'ileostomy-O', '.-O']
['High-O', ',-O', 'dose-O', 'methotrexate-B-Chemical', '(-O', 'HD-O', ',-O', 'MTX-B-Chemical', ')-O', 'is-O', 'an-O', 'important-O', 'treatment-O', 'for-O', 'Burkitt-B-Disease', 'lymphoma-I-Disease', ',-O', 'but-O', 'can-O', 'cause-O', 'hepatic-B-Disease', 'and-O', 'renal-B-Disease', 'toxicity-O', 'when-O', 'its-O', 'clearance-O', 'is-O', 'delayed-O', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'acute-O', 'renal-B-Disease', 'failure-I-Disease', 'after-O', 'HD-O', ',', 'MTX-B-Chemical', 'therapy-O', 'in-O', 'a-O', 'patient-O', 'with-O', 'ileostomy-O', ',', 'The-O', 'patient-O', 'was-O', 'a-O', '3-O', ',', 'year-O', ',', 'old-O', 'boy-O', 'who-O', 'had-O', 'received-O', 'a-O', 'living-O', ',', 'related-O', 'liver-O', 'transplantation-O', 'for-O', 'congenital-O', 'biliary-O', 'atresia-B-Disease', '.-O']
['At-O', 'day-O', '833-O', 'after-O', 'the-O', 'transplantation-O', ',-O', 'he-O', 'was-O', 'diagnosed-O', 'with-O', 'PTLD-B-Disease', '(-O', 'post-transplantation-O', 'lymphoproliferative-O', 'disorder-O', ',-O', 'Burkitt-type-O', 'malignant-O', 'lymphoma-O', ').-O', 'During-O', 'induction-O', 'therapy-O', ',-O', 'he-O', 'suffered-O', 'ileal-O', 'perforation-O', 'and-O', 'ileostomy-O', 'was-O', 'performed-O', '.-O']
['Subsequent-O', 'HD-O', ',-O', 'MTX-B-Chemical', 'therapy-O', 'caused-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'that-O', 'required-O', 'continuous-O', 'hemodialysis-O', '.-O']
['We-O', 'supposed-O', 'that-O', 'intravascular-O', 'hypovolemia-B-Disease', 'due-O', 'to-O', 'substantial-O', 'drainage-O', 'from-O', 'the-O', 'ileostoma-O', 'caused-O', 'acute-B-Disease', 'prerenal-I-Disease', 'failure-I-Disease', '.-O']
['After-O', 'recovery-O', 'of-O', 'his-O', 'renal-O', 'function-O', ',-O', 'we-O', 'could-O', 'safely-O', 'treat-O', 'the-O', 'patient-O', 'with-O', 'HD-O', ',-O', 'MTX-B-Chemical']
['Antithrombotic-O', 'drug-O', 'use-O', ',-O', 'cerebral-O', 'microbleeds-O', ',-O', 'and-O', 'intracerebral-B-Disease', 'hemorrhage-I-Disease', ':-O', 'a-O', 'systematic-O', 'review-O', 'of-O', 'published-O', 'and-O', 'unpublished-O', 'studies-O', '.-O']
['BACKGROUND-O', 'AND-O', 'PURPOSE-O', ':-O', 'Cerebral-O', 'microbleeds-O', '(-O', 'MB-O', ')-O', 'are-O', 'potential-O', 'risk-O', 'factors-O', 'for-O', 'intracerebral-B-Disease', 'hemorrhage-I-Disease', '(-O', 'ICH-B-Disease', ')-O', ',', 'but-O', 'it-O', 'is-O', 'unclear-O', 'if-O', 'they-O', 'are-O', 'a-O', 'contraindication-O', 'to-O', 'using-O', 'antithrombotic-O', 'drugs-O', '.-O']
['Insights-O', 'could-O', 'be-O', 'gained-O', 'by-O', 'pooling-O', 'data-O', 'on-O', 'MB-O', 'frequency-O', 'stratified-O', 'by-O', 'antithrombotic-O', 'use-O', 'in-O', 'cohorts-O', 'with-O', 'ICH-B-Disease', 'and-O', 'ischemic-B-Disease', 'stroke-B-Disease', '(-O', 'IS-B-Disease', ')/-O', 'transient-O', 'ischemic-O', 'attack-O', '(-O', 'TIA-B-Disease', ').-O', 'METHODS-O', ':-O', 'We-O', 'performed-O', 'a-O', 'systematic-O', 'review-O', 'of-O', 'published-O', 'and-O', 'unpublished-O', 'data-O', 'from-O', 'cohorts-O', 'with-O', 'stroke-B-Disease', 'or-O', 'TIA-B-Disease', 'to-O', 'compare-O', 'the-O', 'presence-O', 'of-O', 'MB-O', 'in-O', ':-O', '(1-O', ')', 'antithrombotic-O', 'users-O', 'vs-O', 'nonantithrombotic-O', 'users-O', 'with-O', 'ICH-B-Disease', ';-O', '(2-O', ')', 'antithrombotic-O', 'users-O', 'vs-O', 'nonusers-O', 'with-O', 'IS-B-Disease', '/-O', 'TIA-B-Disease', ';-O', 'and-O', '(-O', '3-O', ')', 'ICH-B-Disease', 'vs-O', 'ischemic-B-Disease', 'events-O', 'stratified-O', 'by-O', 'antithrombotic-O', 'use-O', '.-O']
['We-O', 'also-O', 'analyzed-O', 'published-O', 'and-O', 'unpublished-O', 'follow-O', ',-O', 'up-O', 'data-O', 'to-O', 'determine-O', 'the-O', 'risk-O', 'of-O', 'ICH-B-Disease', 'in-O', 'antithrombotic-O', 'users-O', 'with-O', 'MB-O', '.-O']
['RESULTS-O', ':-O', 'In-O', 'a-O', 'pooled-O', 'analysis-O', 'of-O', '1460-O', 'ICH-B-Disease', 'and-O', '3817-O', 'IS-O', '/-O', 'TIA-B-Disease', ',-O', 'MB-O', 'were-O', 'more-O', 'frequent-O', 'in-O', 'ICH-B-Disease', 'vs-O', 'IS-O', '/-O', 'TIA-B-Disease', 'in-O', 'all-O', 'treatment-O', 'groups-O', ',-O', 'but-O', 'the-O', 'excess-O', 'increased-O', 'from-O', '2-O', '.-O']
['8-O', '(-O', 'odds-O', 'ratio-O', ';-O', 'range-O', ',-O', '2-O', '.-O']
['3-O', ',-O', '3-O', '.-O']
['5-O', ')-O', 'in-O', 'nonantithrombotic-O', 'users-O', 'to-O', '5-O', '.-O']
['7-O', '(-O', 'range-O', ',-O', '3-O', '.-O']
['4-O', ',-O', '9-O', '.-O']
['7-O', ')-O', 'in-O', 'antiplatelet-O', 'users-O', 'and-O', '8-O', '.-O']
['0-O', '(-O', 'range-O', ',-O', '3-O', '.-O']
['5-O', ',-O', '17-O', '.-O']
['8-O', ')-O', 'in-O', 'warfarin-B-Chemical', 'users-O', '(-O', 'P-O', 'difference-O', '=-O', '0-O', '.-O']
['01-O', ').-O', 'There-O', 'was-O', 'also-O', 'an-O', 'excess-O', 'of-O', 'MB-O', 'in-O', 'warfarin-B-Chemical', 'users-O', 'vs-O', 'nonusers-O', 'with-O', 'ICH-B-Disease', '(-O', 'OR-O', ',', '2-O', '.-O']
['7-O', ';-O', '95-O', '%-O', 'CI-O', ',-O', '1-O', '.-O']
['6-O', ',-O', '4-O', '.-O']
['4-O', ';-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ')-O', 'but-O', 'none-O', 'in-O', 'warfarin-B-Chemical', 'users-O', 'with-O', 'IS-B-Disease', '/-O', 'TIA-B-Disease', '(-O', 'OR-O', ',', '1-O', '.-O']
['3-O', ';-O', '95-O', '%-O', 'CI-O', ',-O', '0-O', '.-O']
['9-O', ',-O', '1-O', '.-O']
['7-O', ';-O', 'P-O', '=', '0-O', '.-O']
['33-O', ';-O', 'P-O', 'difference-O', '=-O', '0-O', '.-O']
['01-O', ').-O', 'There-O', 'was-O', 'a-O', 'smaller-O', 'excess-O', 'of-O', 'MB-O', 'in-O', 'antiplatelet-O', 'users-O', 'vs-O', 'nonusers-O', 'with-O', 'ICH-B-Disease', '(-O', 'OR-O', ',-O', '1-O', '.-O']
['7-O', ';-O', '95-O', '%-O', 'CI-O', ',-O', '1-O', '.-O']
['3-O', ',-O', '2-O', '.-O']
['3-O', ';-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', '),-O', 'but-O', 'findings-O', 'were-O', 'similar-O', 'for-O', 'antiplatelet-O', 'users-O', 'with-O', 'IS-B-Disease', '/', 'TIA-B-Disease', '(-O', 'OR-O', ',', '1-O', '.-O']
['4-O', ';-O', '95-O', '%-O', 'CI-O', ',-O', '1-O', '.-O']
['2-O', ',-O', '1-O', '.-O']
['7-O', ';-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ';-O', 'P-O', 'difference-O', '=-O', '0-O', '.-O']
['25-O', ').-O', 'In-O', 'pooled-O', 'follow-O', ',-O', 'up-O', 'data-O', 'for-O', '768-O', 'antithrombotic-O', 'users-O', ',-O', 'presence-O', 'of-O', 'MB-O', 'at-O', 'baseline-O', 'was-O', 'associated-O', 'with-O', 'a-O', 'substantially-O', 'increased-O', 'risk-O', 'of-O', 'subsequent-O', 'ICH-B-Disease', '(-O', 'OR-O', ',-O', '12-O', '.-O']
['1-O', ';-O', '95-O', '%-O', 'CI-O', ',-O', '3-O', '.-O']
['4-O', ',-O', '42-O', '.-O']
['5-O', ';-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'CONCLUSIONS-O', ':-O', 'The-O', 'excess-O', 'of-O', 'MB-O', 'in-O', 'warfarin-B-Chemical', 'users-O', 'with-O', 'ICH-B-Disease', 'compared-O', 'to-O', 'other-O', 'groups-O', 'suggests-O', 'that-O', 'MB-O', 'increase-O', 'the-O', 'risk-O', 'of-O', 'warfarin-B-Chemical', ',-O', 'associated-O', 'ICH-B-Disease', ']
['Verapamil-B-Chemical', 'stimulation-O', 'test-O', 'in-O', 'hyperprolactinemia-B-Disease', ':-O', 'loss-O', 'of-O', 'prolactin-O', 'response-O', 'in-O', 'anatomic-O', 'or-O', 'functional-O', 'stalk-O', 'effect-O', '.-O']
['AIM-O', ':-O', 'Verapamil-B-Chemical', 'stimulation-O', 'test-O', 'was-O', 'previously-O', 'investigated-O', 'as-O', 'a-O', 'tool-O', 'for-O', 'differential-O', 'diagnosis-O', 'of-O', 'hyperprolactinemia-B-Disease', ',-O', 'but-O', 'with-O', 'conflicting-O', 'results-O', '.-O']
['Macroprolactinemia-B-Disease', 'was-O', 'never-O', 'considered-O', 'in-O', 'those-O', 'previous-O', 'studies-O', '.-O']
['Here-O', ',-O', 'we-O', 'aimed-O', 'to-O', 're-O', ',-O', 'investigate-O', 'the-O', 'diagnostic-O', 'value-O', 'of-O', 'verapamil-B-Chemical', 'in-O', 'a-O', 'population-O', 'who-O', 'were-O', 'all-O', 'screened-O', 'for-O', 'macroprolactinemia-B-Disease', '.-O']
['Prolactin-O', 'responses-O', 'to-O', 'verapamil-B-Chemical', 'in-O', '65-O', 'female-O', 'patients-O', '(-O', 'age-O', ':-O', '29-O', '.-O']
['9-O', '+-O', '8-O', '.-O']
['1-O', 'years-O', ')-O', 'with-O', 'hyperprolactinemia-B-Disease', 'were-O', 'tested-O', 'in-O', 'a-O', 'descriptive-O', ',-O', 'matched-O', 'case-O', ',-O', 'control-O', 'study-O', '.-O']
['METHODS-O', ':-O', 'Verapamil-B-Chemical', '80-O', 'mg-O', ',-O', 'p-O', '.-O']
['o-O', '.-O']
['was-O', 'administered-O', ',-O', 'and-O', 'then-O', 'PRL-O', 'levels-O', 'were-O', 'measured-O', 'at-O', '8th-O', 'and-O', '16th-O', 'hours-O', ',-O', 'by-O', 'immunometric-O', 'chemiluminescence-O', '.-O']
['Verapamil-B-Chemical', 'responsiveness-O', 'was-O', 'determined-O', 'by-O', 'peak-O', 'percent-O', 'change-O', 'in-O', 'basal-O', 'prolactin-O', 'levels-O', '(-O', 'PRL-O', ')-O', '.-O', 'RESULTS-O', ':-O', 'Verapamil-B-Chemical', 'significantly-O', 'increased-O', 'PRL-O', 'levels-O', 'in-O', 'healthy-O', 'controls-O', '(-O', 'N-O', ')-O']
['8-O', ',-O', 'PRL-O', ':-O', '183-O', ')-O', 'macroprolactinoma-B-Disease', '(-O', 'N-O', '.-O']
['8-O', ',-O', 'PRL-O', ':-O', '7-O', ')-O', 'microprolactinoma-B-Disease', '(-O', 'N-O', '.-O']
['19-O', ',-O', 'PRL-O', ':-O', '21-O', ')-O', 'macroprolactinemia-B-Disease', '(-O', 'N-O', '.-O']
['23-O', ',-O', 'PRL-O', ':O', '126-O', ')-O', 'but-O', 'not-O', 'in-O', 'pseudoprolactinoma-B-Disease', '(-O', 'N-O', '.-O']
['8-O', ',-O', 'PRL-O', ':-O', '0-O', '.-O']
['8-O', ')-O', ',', 'and-O', 'risperidone-B-Chemical', ',-O', 'induced-O', 'hyperprolactinemia-B-Disease', '(-O', 'N-O', '.-O']
['7-O', ',-O', 'PRL-O', ':-O', '3-O', ').-O', 'ROC-O', 'curve-O', 'analysis-O', 'revealed-O', 'that-O', 'unresponsiveness-O', 'to-O', 'verapamil-B-Chemical', 'defined-O', 'as-O', 'PRL-O', '<-O', '7-O', ',-O', 'discriminated-O', 'anatomical-O', 'or-O', 'functional-O', 'stalk-O', 'effect-O', '(-O', 'sensitivity-O', ':-O', '74-O', ',-O', 'specificity-O', ':-O', '73-O', ',-O', 'AUC-O', ':-O', '0-O', '.-O']
['855-O', '+-O', '0-O', '.-O']
['04-O', ',-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ',-O', 'CI-O', ':-O', '0-O', '.-O']
['768-O', ',-O', '0-O', '.-O']
['942-O', ')-O', 'associated-O', 'with-O', 'pseudoprolactinoma-B-Disease', 'or-O', 'risperidone-B-Chemical', ',-O', 'induced-O', 'hyperprolactinemia-B-Disease', ',-O', 'respectively-O', '.-O']
['CONCLUSION-O', ':-O', 'Verapamil-B-Chemical', 'responsiveness-O', 'is-O', 'not-O', 'a-O', 'reliable-O', 'finding-O', 'for-O', 'the-O', 'differential-O', 'diagnosis-O', 'of-O', 'hyperprolactinemia-B-Disease', '.-O']
['However-O', ',-O', 'verapamil-B-Chemical', 'unresponsiveness-O', 'discriminates-O', 'stalk-O', 'effect-O', '(-O', 'i-O', '.-O']
['e-O', '.-O', 'anatomically-O', 'or-O', 'functionally-O', 'inhibited-O', 'dopaminergic-O', 'tonus-O', ')-O', 'from-O', 'other-O', 'causes-O', 'of-O', 'hyperprolactinemia-B-Disease']
['Central-O', 'action-O', 'of-O', 'narcotic-O', 'analgesics-O', '.-O']
['Part-O', 'IV-O', '.-O']
['Noradrenergic-O', 'influences-O', 'on-O', 'the-O', 'activity-O', 'of-O', 'analgesics-O', 'in-O', 'rats-O', '.-O']
['The-O', 'effect-O', 'of-O', 'clonidine-B-Chemical', ',-O', 'naphazoline-B-Chemical', 'and-O', 'xylometazoline-B-Chemical', 'on-O', 'analgesia-O', 'induced-O', 'by-O', 'morphine-B-Chemical', ',-O', 'codeine-B-Chemical', ',-O', 'fentanyl-B-Chemical', 'and-O', 'pentazocine-B-Chemical', ',-O', 'and-O', 'on-O', 'cataleptic-O', 'effect-O', 'of-O', 'morphine-B-Chemical', ',-O', 'codine-B-Chemical', 'and-O', 'fentanyl-B-Chemical', 'was-O', 'studied-O', 'in-O', 'rats-O', '.-O']
['The-O', 'biochemical-O', 'assays-O', 'on-O', 'the-O', 'influence-O', 'of-O', 'four-O', 'analgesics-O', 'on-O', 'the-O', 'brain-O', 'concentration-O', 'and-O', 'turnover-O', 'of-O', 'noradrenaline-B-Chemical', '(-O', 'NA-B-Chemical', ')-O', 'were-O', 'also-O', 'performed-O', '.-O']
['It-O', 'was-O', 'found-O', 'that-O', 'three-O', 'drugs-O', 'stimulating-O', 'central-O', 'NA-O', 'receptors-O', 'failed-O', 'to-O', 'affect-O', 'the-O', 'analgesic-O', 'ED50-O', 'of-O', 'all-O', 'antinociceptive-O', 'agents-O', 'and-O', 'they-O', 'enhanced-O', 'catalepsy-B-Disease', 'induced-O', 'by-O', 'morphine-B-Chemical', 'and-O', 'fentanyl-B-Chemical', '.-O']
['Codeine-B-Chemical', 'catalepsy-B-Disease', 'was-O', 'increased-O', 'by-O', 'clonidine-B-Chemical', 'and-O', 'decreased-O', 'by-O', 'naphazoline-B-Chemical', 'and-O', 'xylometazoline-B-Chemical', '.-O']
['The-O', 'brain-O', 'concentration-O', 'of-O', 'NA-B-Chemical', 'was-O', 'not-O', 'changed-O', 'by-O', 'morphine-B-Chemical', 'and-O', 'fentanyl-B-Chemical', ',-O', 'but-O', 'one-O', 'of-O', 'the-O', 'doses-O', 'of-O', 'codeine-B-Chemical', '(-O', '45-O', 'mg-O', '/-O', 'kg-O', ')-O', 'slightly-O', 'enhanced-O', 'it-O', '.-O']
['Pentazocine-B-Chemical', 'dose-O', ',-O', 'dependently-O', 'decreased-O', 'the-O', 'brain-O', 'level-O', 'of-O', 'NA-B-Chemical', '.-O']
['The-O', 'rate-O', 'of-O', 'NA-B-Chemical', 'turnover-O', 'was-O', 'not-O', 'altered-O', 'by-O', 'analgesics-O', 'except-O', 'for-O', 'the-O', 'higher-O', 'dose-O', 'of-O', 'fentanyl-B-Chemical', '(-O', '0-O', '.-O']
['2-O', 'mg-O', '/-O', 'kg-O', ')-O', 'following-O', 'which-O', 'the-O', 'disappearance-O', 'of-O', 'NA-B-Chemical', 'from-O', 'the-O', 'brain-O', 'was-O', 'diminished-O', '.-O']
['The-O', 'results-O', 'are-O', 'discussed-O', 'in-O', 'the-O', 'light-O', 'of-O', 'various-O', 'and-O', 'non-O', ',-O', 'uniform-O', 'data-O', 'from-O', 'the-O', 'literature-O', '.-O']
['It-O', 'is-O', 'suggested-O', 'that-O', 'in-O', 'rats-O', 'the-O', 'brain-O', 'NA-B-Chemical', 'plays-O', 'a-O', 'less-O', 'important-O', 'function-O', 'than-O', 'the-O', 'other-O', 'monoamines-O']
['Modification-O', 'by-O', 'propranolol-B-Chemical', 'of-O', 'cardiovascular-O', 'effects-O', 'of-O', 'induced-O', 'hypoglycaemia-B-Disease', '.-O']
['The-O', 'cardiovascular-O', 'effects-O', 'of-O', 'hypoglycaemia-B-Disease', ',-O', 'with-O', 'and-O', 'without-O', 'beta-O', ',-O', 'blockade-O', ',-O', 'were-O', 'compared-O', 'in-O', 'fourteen-O', 'healthy-O', 'men-O', '.-O']
['Eight-O', 'received-O', 'insulin-B-Chemical', 'alone-O', ',-O', 'and-O', 'eight-O', ',-O', 'including-O', 'two-O', 'of-O', 'the-O', 'original-O', 'insulin-B-Chemical', ',-O', 'only-O', 'group-O', ',-O', 'were-O', 'given-O', 'propranolol-B-Chemical', 'and-O', 'insulin-B-Chemical', '.-O']
['In-O', 'the-O', 'insulin-B-Chemical', ',-O', 'group-O', 'the-O', 'period-O', 'of-O', 'hypoglycaemia-B-Disease', 'was-O', 'associated-O', 'with-O', 'an-O', 'increase-O', 'in-O', 'heart-O', ',-O', 'rate-O', 'and-O', 'a-O', 'fall-O', 'in-O', 'diastolic-O', 'blood-O', ',-O', 'pressure-O', '.-O']
['In-O', 'the-O', 'propranolol-B-Chemical', ',-O', 'insulin-B-Chemical', 'group-O', 'there-O', 'was-O', 'a-O', 'significant-O', 'fall-O', 'in-O', 'heart-O', ',-O', 'rate-O', 'in-O', 'most-O', 'subjects-O', 'and-O', 'an-O', 'increase-O', 'in-O', 'diastolic-O', 'pressure-O', '.-O']
['Typical-O', 'S-O', ',-O', 'T-O', '/-O', 'T-O', 'changes-O', 'occurred-O', 'in-O', 'the-O', 'insulin-B-Chemical', ',-O', 'group-O', 'but-O', 'in-O', 'none-O', 'of-O', 'the-O', 'propranolol-B-Chemical', ',-O', 'insulin-B-Chemical', 'group-O', '.-O']
['Hypertension-B-Disease', 'in-O', 'diabetics-B-Disease', 'prone-O', 'to-O', 'hypoglycaemia-B-Disease']
['Prevention-O', 'and-O', 'treatment-O', 'of-O', 'endometrial-B-Disease', 'disease-I-Disease', 'in-O', 'climacteric-O', 'women-O', 'receiving-O', 'oestrogen-B-Chemical', 'therapy-O', '.-O']
['The-O', 'treatment-O', 'regimens-O', 'are-O', 'described-O', 'in-O', '74-O', 'patients-O', 'with-O', 'endometrial-B-Disease', 'disease-I-Disease', 'among-O', '850-O', 'climacteric-O', 'women-O', 'receiving-O', 'oestrogen-B-Chemical', 'therapy-O', '.-O']
['Cystic-B-Disease', 'hyperplasia-I-Disease', 'was-O', 'associated-O', 'with-O', 'unopposed-O', 'oestrogen-B-Chemical', 'therapy-O', 'without-O', 'progestagen-B-Chemical', '.-O']
['Two-O', 'courses-O', 'of-O', '21-O', 'days-O', 'of-O', '5-O', 'mg-O', 'norethisterone-B-Chemical', 'daily-O', 'caused-O', 'reversion-O', 'to-O', 'normal-O', 'in-O', 'all-O', '57-O', 'cases-O', 'of-O', 'cystic-B-Disease', 'hyperplasia-I-Disease', 'and-O', '6-O', 'of-O', 'the-O', '8-O', 'cases-O', 'of-O', 'atypical-B-Disease', 'hyperplasia-I-Disease', '.-O']
['4-O', 'cases-O', 'of-O', 'endometrial-B-Disease', 'carcinoma-I-Disease', 'referred-O', 'from-O', 'elsewhere-O', 'demonstrated-O', 'the-O', 'problems-O', 'of-O', 'inappropriate-O', 'and-O', 'unsupervised-O', 'unopposed-O', 'oestrogen-B-Chemical', 'therapy-O', 'and-O', 'the-O', 'difficulty-O', 'in-O', 'distinguishing-O', 'severe-O', 'hyperplasia-B-Disease', 'from-O', 'malignancy-I-Disease', '.-O']
['Cyclical-O', 'low-O', ',-O', 'dose-O', 'oestrogen-B-Chemical', 'therapy-O', 'with-O', '7-O', '--O', '13-O', 'days-O', 'of-O', 'progestagen-B-Chemical', 'does-O', 'not-O', 'seem-O', 'to-O', 'increase-O', 'the-O', 'risk-O', 'of-O', 'endometrial-B-Disease', 'hyperplasia-I-Disease', 'or-O', 'carcinoma-I-Disease']
['Pure-O', 'red-O', 'cell-O', 'aplasia-B-Disease', ',-O', 'toxic-O', 'dermatitis-B-Disease', 'and-O', 'lymphadenopathy-B-Disease', 'in-O', 'a-O', 'patient-O', 'taking-O', 'diphenylhydantoin-B-Chemical', '.-O']
['A-O', 'patient-O', 'taking-O', 'diphenylhydantoin-B-Chemical', 'for-O', '3-O', 'weeks-O', 'developed-O', 'a-O', 'generalized-O', 'skin-O', 'rash-B-Disease', ',-O', 'lymphadenopathy-B-Disease', 'and-O', 'pure-O', 'red-O', 'cell-O', 'aplasia-B-Disease', '.-O']
['After-O', 'withdrawal-O', 'of-O', 'the-O', 'pharmacon-O', 'all-O', 'symptoms-O', 'disappeared-O', 'spontaneously-O', '.-O']
['Skin-O', 'rash-B-Disease', 'is-O', 'a-O', 'well-O', ',-O', 'known-O', 'complication-O', 'of-O', 'diphenylhydantoin-B-Chemical', 'treatment-O', 'as-O', 'is-O', 'benign-O', 'and-O', 'malignant-O', 'lymphadenopathy-B-Disease', '.-O']
['Pure-O', 'red-O', 'cell-O', 'aplasia-B-Disease', 'associated-O', 'with-O', 'diphenylhydantoin-B-Chemical', 'medication-O', 'has-O', 'been-O', 'reported-O', 'in-O', '3-O', 'patients-O', '.-O']
['The-O', 'exact-O', 'mechanism-O', 'by-O', 'which-O', 'diphenylhydantoin-B-Chemical', 'exerts-O', 'its-O', 'toxic-O', 'effects-O', 'is-O', 'not-O', 'known-O', '.-O']
['In-O', 'this-O', 'patient-O', 'the-O', 'time-O', 'relation-O', 'between-O', 'the-O', 'ingestion-O', 'of-O', 'diphenylhydantoin-B-Chemical', 'and-O', 'the-O', 'occurrence-O', 'of-O', 'the-O', 'skin-B-Disease', 'rash-I-Disease', ',-O', 'lymphadenopathy-B-Disease', 'and-O', 'pure-O', 'red-O', 'cell-O', 'aplasia-B-Disease']
['Continuous-O', 'infusion-O', 'tobramycin-B-Chemical', 'combined-O', 'with-O', 'carbenicillin-B-Chemical', 'for-O', 'infections-O', 'in-O', 'cancer-B-Disease', 'patients-O', '.-O']
['The-O', 'cure-O', 'rate-O', 'of-O', 'infections-B-Disease', 'in-O', 'cancer-B-Disease', 'patients-O', 'is-O', 'adversely-O', 'affected-O', 'by-O', 'neutropenia-B-Disease', '(-O', 'less-O', 'than-O', '1-O', ',', '000-O', '/-O', 'mm3-O', ').-O', 'In-O', 'particular-O', ',-O', 'patients-O', 'with-O', 'severe-O', 'neutropenia-B-Disease', '(-O', 'less-O', 'than-O', '100-O', '/-O', 'mm3-O', ')-O', 'have-O', 'shown-O', 'a-O', 'poor-O', 'response-O', 'to-O', 'antibiotics-B-Chemical', '.-O']
['To-O', 'overcome-O', 'the-O', 'adverse-O', 'effects-O', 'of-O', 'neutropenia-B-Disease', ',-O', 'tobramycin-B-Chemical', 'was-O', 'given-O', 'by-O', 'continuous-O', 'infusion-O', 'and-O', 'combined-O', 'with-O', 'intermittent-O', 'carbenicillin-B-Chemical', '.-O']
['Tobramycin-B-Chemical', 'was-O', 'given-O', 'to-O', 'a-O', 'total-O', 'daily-O', 'dose-O', 'of-O', '300-O', 'mg-O', '/-O', 'm2-O', 'and-O', 'carbenicillin-B-Chemical', 'was-O', 'given-O', 'at-O', 'a-O', 'dose-O', 'of-O', '5-O', 'gm-O', 'every-O', 'four-O', 'hours-O', '.-O']
['There-O', 'were-O', '125-O', 'infectious-O', 'episodes-O', 'in-O', '116-O', 'cancer-B-Disease', 'patients-O', 'receiving-O', 'myelosuppressive-O', 'chemotherapy-O', '.-O']
['The-O', 'overall-O', 'cure-O', 'rate-O', 'was-O', '70-O', '.-O', 'Pneumonia-B-Disease', 'was-O', 'the-O', 'most-O', 'common-O', 'infection-O', 'and-O', '61-O', '%-O', 'of-O', '59-O', 'episodes-O', 'were-O', 'cured-O', '.-O']
['Gram-O', ',-O', 'negative-O', 'bacilli-O', 'were-O', 'the-O', 'most-O', 'common-O', 'causative-O', 'organisms-O', 'and-O', '69-O', '%-O', 'of-O', 'these-O', 'infections-B-Disease', 'were-O', 'cured-O', '.-O']
['The-O', 'most-O', 'common-O', 'pathogen-O', 'was-O', 'Klebsiella-B-Disease', 'pneumoniae-B-Disease', 'and-O', 'this-O', ',-O', 'together-O', 'with-O', 'Escherichia-B-Disease', 'coli-B-Disease', 'and-O', 'Pseudomonas-B-Disease', 'aeruginosa-B-Disease', ',-O', 'accounted-O', 'for-O', '74-O', '%-O', 'of-O', 'all-O', 'gram-negative-O', 'bacillary-O', 'infections-B-Disease', '.-O']
['Response-O', 'was-O', 'not-O', 'influenced-O', 'by-O', 'the-O', 'initial-O', 'neutrophil-O', 'count-O', ',-O', 'with-O', 'a-O', '62-O', '%-O', 'cure-O', 'rate-O', 'for-O', '39-O', 'episodes-O', 'associated-O', 'with-O', 'severe-O', 'neutropenia-B-Disease', '.-O']
['However-O', ',-O', 'failure-O', 'of-O', 'the-O', 'neutrophil-O', 'count-O', 'to-O', 'increase-O', 'during-O', 'therapy-O', 'adversely-O', 'affected-O', 'response-O', '.-O']
['Azotemia-B-Disease', 'was-O', 'the-O', 'major-O', 'side-O', 'effect-O', 'recognized-O', ',-O', 'and-O', 'it-O', 'occurred-O', 'in-O', '11-O', '%-O', 'of-O', 'episodes-O', '.-O']
['Major-O', 'azotemia-B-Disease', '(-O', 'serum-O', 'creatinine-B-Chemical', 'greater-O', 'than-O', '2-O', '.-O']
['5-O', 'mg-O', '/-O', 'dl-O', 'or-O', 'BUN-O', 'greater-O', 'than-O', '50-O', 'mg-O', '/-O', 'dl-O', ')-O', 'occurred-O', 'in-O', 'only-O', '2-O', '.-O', 'Azotemia-B-Disease', 'was-O', 'not-O', 'related-O', 'to-O', 'duration-O', 'of-O', 'therapy-O', 'or-O', 'serum-O', 'tobramycin-B-Chemical', 'concentration-O', '.-O']
['This-O', 'antibiotic-O', 'regimen-O', 'showed-O', 'both-O', 'therapeutic-O', 'efficacy-O', 'and-O', 'acceptable-O', 'renal-B-Disease', 'toxicity-B-Disease']
['Recurrent-O', 'subarachnoid-B-Disease', 'hemorrhage-I-Disease', 'associated-O', 'with-O', 'aminocaproic-B-Chemical', 'acid-I-Chemical', 'therapy-O', 'and-O', 'acute-O', 'renal-O', 'artery-O', 'thrombosis-B-Disease', '.-O']
['Case-O', 'report-O', '.-O']
['Epsilon-O', 'aminocaproic-B-Chemical', 'acid-O', '(-O', 'EACA-B-Chemical', ')', 'has-O', 'been-O', 'used-O', 'to-O', 'prevent-O', 'rebleeding-O', 'in-O', 'patients-O', 'with-O', 'subarachnoid-B-Disease', 'hemorrhage-I-Disease', '(-O', 'SAH-B-Disease', ').-O', 'Although-O', 'this-O', 'agent-O', 'does-O', 'decrease-O', 'the-O', 'frequency-O', 'of-O', 'rebleeding-O', ',-O', 'several-O', 'reports-O', 'have-O', 'described-O', 'thrombotic-B-Disease', 'complications-O', 'of-O', 'EACA-B-Chemical', 'therapy-O', '.-O']
['These-O', 'complications-O', 'have-O', 'included-O', 'clinical-O', 'deterioration-O', 'and-O', 'intracranial-B-Disease', 'vascular-I-Disease', 'thrombosis-I-Disease', 'in-O', 'patients-O', 'with-O', 'SAH-B-Disease', ',-O', 'arteriolar-O', 'and-O', 'capillary-O', 'fibrin-O', 'thrombi-O', 'in-O', 'patients-O', 'with-O', 'fibrinolytic-O', 'syndromes-O', 'treated-O', 'with-O', 'EACA-B-Chemical', ',-O', 'or-O', 'other-O', 'thromboembolic-O', 'phenomena-O', '.-O']
['Since-O', 'intravascular-B-Disease', 'fibrin-O', 'thrombi-O', 'are-O', 'often-O', 'observed-O', 'in-O', 'patients-O', 'with-O', 'fibrinolytic-O', 'disorders-O', ',-O', 'EACA-B-Chemical', 'should-O', 'not-O', 'be-O', 'implicated-O', 'in-O', 'the-O', 'pathogenesis-O', 'of-O', 'fibrin-O', 'thrombi-O', 'in-O', 'patients-O', 'with-O', 'disseminated-B-Disease', 'intravascular-B-Disease', 'coagulation-O', 'or-O', 'other-O', 'x-O', 'consumption-O', 'coagulopathies-O', '.-O', 'This-O', 'report-O', 'describes-O', 'subtotal-O', 'infarction-O', 'of-O', 'the-O', 'kidney-O', 'due-O', 'to-O', 'thrombosis-O', 'of-O', 'a-O', 'normal-O', 'renal-O', 'artery-O', '.-O']
['This-O', 'occlusion-O', 'occurred-O', 'after-O', 'EACA-B-Chemical', 'therapy-O', 'in-O', 'a-O', 'patient-O', 'with-O', 'SAH-B-Disease', 'and-O', 'histopathological-O', 'documentation-O', 'of-O', 'recurrent-O', 'SAH-B-Disease', '.-O']
['The-O', 'corresponding-O', 'clinical-O', 'event-O', 'was-O', 'characterized-O', 'by-O', 'marked-O', 'hypertension-B-Disease']
['Long-O', ',-O', 'term-O', 'propranolol-B-Chemical', 'therapy-O', 'in-O', 'pregnancy-O', ':-O', 'maternal-O', 'and-O', 'fetal-O', 'outcome-O', '.-O']
['Propranolol-B-Chemical', ',-O', 'a-O', 'beta-O', ',-O', 'adrenergic-O', 'blocking-O', 'agent-O', ',-O', 'has-O', 'found-O', 'an-O', 'important-O', 'position-O', 'in-O', 'the-O', 'practice-O', 'of-O', 'medicine-O', '.-O']
['Its-O', 'use-O', 'in-O', 'pregnancy-O', ',-O', 'however-O', ',-O', 'is-O', 'an-O', 'open-O', 'question-O', 'as-O', 'a-O', 'number-O', 'of-O', 'detrimental-O', 'side-O', 'effects-O', 'have-O', 'been-O', 'reported-O', 'in-O', 'the-O', 'fetus-O', 'and-O', 'neonate-O', '.-O']
['Ten-O', 'patients-O', 'and-O', '12-O', 'pregnancies-O', 'are-O', 'reported-O', 'where-O', 'chronic-O', 'propranolol-B-Chemical', 'has-O', 'been-O', 'administered-O', '.-O']
['Five-O', 'patients-O', 'with-O', 'serial-O', 'pregnancies-O', 'with-O', 'and-O', 'without-O', 'propranolol-B-Chemical', 'therapy-O', 'are-O', 'also-O', 'examined-O', '.-O']
['Maternal-O', ',-O', 'fetal-O', ',-O', 'and-O', 'neonatal-O', 'complications-O', 'are-O', 'examined-O', '.-O']
['An-O', 'attempt-O', 'is-O', 'made-O', 'to-O', 'differentiate-O', 'drug-O', ',-O', 'related-O', 'complications-O', 'from-O', 'maternal-O', 'disease-B-Disease', '--O', 'related-O', 'complications-O', '.-O']
['We-O', 'conclude-O', 'that-O', 'previously-O', 'reported-O', 'hypoglycemia-B-Disease', ',-O', 'hyperbilirubinemia-B-Disease', ',-O', 'polycythemia-B-Disease', ',-O', 'neonatal-O', 'apnea-B-Disease', ',-O', 'and-O', 'bradycardia-B-Disease', 'are-O', 'not-O', 'invariable-O', 'and-O', 'cannot-O', 'be-O', 'statistically-O', 'correlated-O', 'with-O', 'chronic-O', 'propranolol-B-Chemical', 'therapy-O', '.-O']
['Growth-O', 'retardation-I-Disease']
['Use-O', 'of-O', 'propranolol-B-Chemical', 'in-O', 'the-O', 'treatment-O', 'of-O', 'idiopathic-B-Disease', 'orthostatic-I-Disease', 'hypotension-I-Disease', '.-O']
['Five-O', 'patients-O', 'with-O', 'idiopathic-B-Disease', 'orthostatic-B-Disease', 'hypotension-I-Disease', 'who-O', 'had-O', 'physiologic-O', 'and-O', 'biochemical-O', 'evidence-O', 'of-O', 'severe-O', 'autonomic-B-Disease', 'dysfunction-I-Disease', 'were-O', 'included-O', 'in-O', 'the-O', 'study-O', '.-O']
['They-O', 'all-O', 'exhibited-O', 'markedly-O', 'reduced-O', 'plasma-O', 'catecholamines-B-Chemical', 'and-O', 'plasma-O', 'renin-O', 'activity-O', 'in-O', 'both-O', 'recumbent-O', 'and-O', 'upright-O', 'positions-O', 'and-O', 'had-O', 'marked-O', 'hypersensitivity-O', 'to-O', 'the-O', 'pressor-O', 'effects-O', 'of-O', 'infused-O', 'norepinephrine-B-Chemical', '.-O']
['Treatment-O', 'with-O', 'propanolol-B-Chemical', 'administered-O', 'intravenously-O', '(-O', '1-O', ',-O', '5-O', 'mg-O', ')-O', 'produced-O', 'increases-O', 'in-O', 'supine-O', 'and-O', 'upright-O', 'blood-O', 'pressure-O', 'in-O', '4-O', 'of-O', 'the-O', '5-O', 'individuals-O', 'with-O', 'rises-O', 'ranging-O', 'from-O', '11-O', '/-O', '6-O', 'to-O', '22-O', '/-O', '11-O', 'mmHg-O', '.-O']
['Chronic-O', 'oral-O', 'administration-O', 'of-O', 'propranolol-B-Chemical', '(-O', '40-O', ',-O', '160-O', 'mg-O', '/-O', 'day-O', ')-O', 'also-O', 'elevated-O', 'the-O', 'blood-O', 'pressures-O', 'of-O', 'these-O', 'individuals-O', 'with-O', 'increases-O', 'in-O', 'the-O', 'order-O', 'of-O', '20-O', ',-O', '35-O', '/-O', '15-O', ',-O', '25-O', 'mmg-O', 'being-O', 'observed-O', '.-O']
['In-O', '1-O', 'patient-O', ',-O', 'marked-O', 'hypertension-B-Disease', 'was-O', 'induced-O', 'by-O', 'propranolol-B-Chemical', 'and-O', 'the-O', 'drug-O', 'had-O', 'to-O', 'be-O', 'withdrawn-O', '.-O']
['It-O', 'otherwise-O', 'was-O', 'well-O', 'tolerated-O', 'and-O', 'no-O', 'important-O', 'side-O', 'effects-O', 'were-O', 'observed-O', '.-O']
['Treatment-O', 'has-O', 'been-O', 'continued-O', 'in-O', '3-O', 'individuals-O', 'for-O', '6-O', ',-O', '13-O', 'months-O', 'with-O', 'persistence-O', 'of-O', 'the-O', 'pressor-O', 'effect-O', ',-O', 'although-O', 'there-O', 'appears-O', 'to-O', 'have-O', 'been-O', 'some-O', 'decrease-O', 'in-O', 'the-O', 'degree-O', 'of-O', 'response-O', 'with-O', 'time-O', '.-O']
['Hemodynamic-O', 'measurements-O', 'in-O', '1-O', 'of-O', 'the-O', 'patients-O', 'demonstrated-O', 'an-O', 'increase-O', 'in-O', 'total-O', 'peripheral-O', 'resistance-O', 'and-O', 'essentially-O', 'no-O', 'change-O', 'in-O', 'cardiac-O', 'output-O', 'following-O', 'propranolol-B-Chemical', 'therapy-O', '.-O']
['The-O', 'studies-O', 'suggest-O', 'that-O', 'propranolol-B-Chemical', 'is-O', 'a-O', 'useful-O', 'drug-O', 'in-O', 'selected-O', 'patients-O', 'with-O', 'severe-O', 'idiopathic-B-Disease', 'orthostatic-B-Disease', 'hypotension-I-Disease']
['Total-O', 'intravenous-O', 'anesthesia-O', 'with-O', 'etomidate-B-Chemical', '.-O']
['III-O', '.-O']
['Some-O', 'observations-O', 'in-O', 'adults-O', '.-O']
['An-O', 'investigation-O', 'was-O', 'undertaken-O', 'to-O', 'determine-O', 'the-O', 'dosage-O', 'of-O', 'etomidate-B-Chemical', 'required-O', 'to-O', 'maintain-O', 'sleep-O', 'in-O', 'adults-O', 'undergoing-O', 'surgery-O', 'under-O', 'regional-O', 'local-O', 'anesthesia-O', '.-O']
['Premedication-O', 'of-O', 'diazepam-B-Chemical', '10-O', 'mg-O', 'and-O', 'atropine-B-Chemical', '0-O', '.-O']
['5-O', 'mg-O', 'was-O', 'given-O', ',-O', 'and-O', 'sleep-O', 'was-O', 'induced-O', 'and-O', 'maintained-O', 'by-O', 'intermittent-O', 'intravenous-O', 'injections-O', 'of-O', 'etomidate-B-Chemical', '0-O', '.-O']
['1-O', '/-O', 'mg-O', '/-O', 'kg-O', ',-O', 'given-O', 'whenever-O', 'the-O', 'patient-O', 'would-O', 'open-O', 'his-O', 'eyes-O', 'on-O', 'request-O', '.-O']
['A-O', 'mean-O', 'overall-O', 'dose-O', 'of-O', 'etomidate-B-Chemical', '17-O', '.-O']
['4-O', 'microgram-O', '/-O', 'kg-O', '/-O', 'min-O', '.-O']
['was-O', 'required-O', 'to-O', 'maintain-O', 'sleep-O', ',-O', 'but-O', 'great-O', 'individual-O', 'variation-O', 'occurred-O', ',-O', 'with-O', 'older-O', 'patients-O', 'requiring-O', 'less-O', 'drug-O', '.-O']
['The-O', 'investigation-O', 'was-O', 'discontinued-O', 'after-O', '18-O', 'patients-O', 'because-O', 'of-O', 'the-O', 'frequency-O', 'and-O', 'intensity-O', 'of-O', 'side-O', ',-O', 'effects-O', ',-O', 'particularly-O', 'pain-B-Disease', 'and-O', 'myoclonia-B-Disease', ',-O', 'which-O', 'caused-O', 'the-O', 'technique-O', 'to-O', 'be-O', 'abandoned-O', 'in-O', 'two-O', 'cases-O', '.-O']
['It-O', 'is-O', 'considered-O', 'unlikely-O', 'that-O', 'etomidate-B-Chemical', 'will-O', 'prove-O', 'to-O', 'be-O', 'the-O', 'hypnotic-O', 'of-O', 'choice-O', 'for-O', 'a-O', 'totally-O', 'intravenous-O', 'anesthetic-O', 'technique-O', 'in-O', 'adults-O', 'because-O', 'of-O', 'the-O', 'high-O', 'incidence-O', 'of-O', 'myoclonia-B-Disease']
['A-O', 'method-O', 'for-O', 'the-O', 'measurement-O', 'of-O', 'tremor-B-Disease', ',-O', 'and-O', 'a-O', 'comparison-O', 'of-O', 'the-O', 'effects-O', 'of-O', 'tocolytic-O', 'beta-B-Chemical', ',-O', 'mimetics-O', '.-O']
['A-O', 'method-O', 'permitting-O', 'measurement-O', 'of-O', 'finger-O', 'tremor-B-Disease', 'as-O', 'a-O', 'displacement-O', ',-O', 'time-O', 'curve-O', 'is-O', 'described-O', ',-O', 'using-O', 'a-O', 'test-O', 'system-O', 'with-O', 'simple-O', 'amplitude-O', 'calibration-O', '.-O']
['The-O', 'coordinates-O', 'of-O', 'the-O', 'inversion-O', 'points-O', 'of-O', 'the-O', 'displacement-O', ',-O', 'time-O', 'curves-O', 'were-O', 'transferred-O', 'through-O', 'graphical-O', 'input-O', 'equipment-O', 'to-O', 'punched-O', 'tape-O', '.-O']
['By-O', 'means-O', 'of-O', 'a-O', 'computer-O', 'program-O', ',-O', 'periods-O', 'and-O', 'amplitudes-O', 'of-O', 'tremor-B-Disease', 'oscillations-O', 'were-O', 'calculated-O', 'and-O', 'classified-O', '.-O']
['The-O', 'event-O', 'frequency-O', 'for-O', 'each-O', 'class-O', 'of-O', 'periods-O', 'and-O', 'amplitudes-O', 'was-O', 'determined-O', '.-O']
['The-O', 'actions-O', 'of-O', 'fenoterol-hydrobromide-B-Chemical', ',-O', 'ritodrin-HCl-B-Chemical', 'and-O', 'placebo-O', 'given-O', 'to-O', '10-O', 'healthy-O', 'subjects-O', 'by-O', 'intravenous-O', 'infusion-O', 'in-O', 'a-O', 'double-O', ',-O', 'blind-O', 'crossover-O', 'study-O', 'were-O', 'tested-O', 'by-O', 'this-O', 'method-O', '.-O']
['At-O', 'therapeutic-O', 'doses-O', 'both-O', 'substances-O', 'raised-O', 'the-O', 'mean-O', 'tremor-B-Disease', 'amplitude-O', 'to-O', 'about-O', 'three-O', 'times-O', 'the-O', 'control-O', 'level-O', '.-O']
['At-O', 'the-O', 'same-O', 'time-O', ',-O', 'the-O', 'mean-O', 'period-O', 'within-O', 'each-O', 'class-O', 'of-O', 'amplitudes-O', 'shortened-O', 'by-O', '10-O', '--O', '20-O', 'ms-O', ',-O', 'whereas-O', 'the-O', 'mean-O', 'periods-O', 'calculated-O', 'from-O', 'all-O', 'oscillations-O', 'together-O', 'did-O', 'not-O', 'change-O', 'significantly-O', '.-O']
['After-O', 'the-O', 'end-O', 'of-O', 'fenoterol-hydrobromide-B-Chemical', 'infusion-O', ',-O', 'tremor-B-Disease', 'amplitudes-O', 'decreased-O', 'significantly-O', 'faster-O', 'than-O', 'those-O', 'following-O', 'ritodrin-HCl-B-Chemical']
['Bilateral-O', 'retinal-B-Disease', 'artery-O', 'and-O', 'choriocapillaris-B-Disease', 'occlusion-I-Disease', 'following-O', 'the-O', 'injection-O', 'of-O', 'long-O', 'acting-O', 'corticosteroid-B-Chemical', 'suspensions-O', 'in-O', 'combination-O', 'with-O', 'other-O', 'drugs-O', ':-O', 'I-O', '.-O']
['Clinical-O', 'studies-O', '.-O']
['Two-O', 'well-O', ',-O', 'documented-O', 'cases-O', 'of-O', 'bilateral-O', 'retinal-B-Disease', 'artery-O', 'and-O', 'choriocapillaris-O', 'occlusions-O', 'with-O', 'blindness-O', 'following-O', 'head-O', 'and-O', 'neck-O', 'soft-O', 'tissue-O', 'injection-O', 'with-O', 'methylprednisolone-B-Chemical', 'acetate-O', 'in-O', 'combination-O', 'with-O', 'lidocaine-B-Chemical', ',-O', 'epinephrine-B-Chemical', ',-O', 'or-O', 'penicillin-B-Chemical', 'are-O', 'reported-O', '.-O']
['One-O', 'case-O', 'had-O', 'only-O', 'a-O', 'unilateral-O', 'injection-O', '.-O']
['The-O', 'acute-O', 'observations-O', 'included-O', 'hazy-O', 'sensorium-O', ',-O', 'superior-O', 'gaze-O', 'palsy-B-Disease', ',-O', 'pupillary-O', 'abnormalities-O', ',-O', 'and-O', 'conjunctival-O', 'hemorrhages-B-Disease', 'with-O', 'edema-I-Disease', '.-O']
['Follow-O', ',-O', 'up-O', 'changes-O', 'showed-O', 'marked-O', 'visual-B-Disease', 'loss-I-Disease', ',-O', 'constricted-O', 'visual-O', 'fields-O', ',-O', 'optic-O', 'nerve-O', 'pallor-O', ',-O', 'vascular-O', 'attenuation-O', ',-O', 'and-O', 'chorioretinal-B-Disease', 'atrophy-I-Disease']
['Cephalothin-B-Chemical', ',-O', 'induced-O', 'immune-O', 'hemolytic-B-Disease', 'anemia-I-Disease', '.-O']
['A-O', 'patient-O', 'with-O', 'renal-B-Disease', 'disease-O', 'developed-O', 'Coombs-O', ',-O', 'positive-O', 'hemolytic-B-Disease', 'anemia-I-Disease', 'while-O', 'receiving-O', 'cephalothin-B-Chemical', 'therapy-O', '.-O']
['An-O', 'anti-O', ',-O', 'cephalothin-B-Chemical', 'IgG-O', 'antibody-O', 'was-O', 'detected-O', 'in-O', 'the-O', 'patient-O', 'x-O', 's-O', 'serum-O', 'and-O', 'in-O', 'the-O', 'eluates-O', 'from-O', 'her-O', 'erythrocytes-O', '.-O']
['In-O', 'addition-O', ',-O', 'nonimmunologic-O', 'binding-O', 'of-O', 'normal-O', 'and-O', 'patient-O', 'x-O', 's-O', 'serum-O', 'proteins-O', 'to-O', 'her-O', 'own-O', 'and-O', 'cephalothin-B-Chemical', ',-O', 'coated-O', 'normal-O', 'red-O', 'cells-O', 'was-O', 'demonstrated-O', '.-O']
['Skin-O', 'tests-O', 'and-O', 'in-O', 'vitro-O', 'lymphocyte-O', 'stimulation-O', 'revealed-O', 'that-O', 'the-O', 'patient-O', 'was-O', 'sensitized-O', 'to-O', 'cephalothin-B-Chemical', 'and-O', 'also-O', 'to-O', 'ampicillin-B-Chemical', '.-O']
['Careful-O', 'investigation-O', 'of-O', 'drug-O', ',-O', 'induced-O', 'hemolytic-B-Disease', 'anemias-I-Disease']
['Kaliuretic-O', 'effect-O', 'of-O', 'L-dopa-B-Chemical', 'treatment-O', 'in-O', 'parkinsonian-B-Disease', 'patients-O', '.-O']
['Hypokalemia-B-Disease', ',-O', 'sometimes-O', 'severe-O', ',-O', 'was-O', 'observed-O', 'in-O', 'some-O', 'L-dopa-B-Chemical', ',-O', 'treated-O', 'parkinsonian-B-Disease', 'patients-O', '.-O']
['The-O', 'influence-O', 'of-O', 'L-dopa-B-Chemical', 'on-O', 'the-O', 'renal-O', 'excretion-O', 'of-O', 'potassium-B-Chemical', 'was-O', 'studied-O', 'in-O', '3-O', 'patients-O', 'with-O', 'hypokalemia-B-Disease', 'and-O', 'in-O', '5-O', 'normokalemic-O', 'patients-O', 'by-O', 'determination-O', 'of-O', 'renal-O', 'plasma-O', 'flow-O', ',-O', 'glomerular-O', 'filtration-O', 'rate-O', ',-O', 'plasma-O', 'concentration-O', 'of-O', 'potassium-B-Chemical', 'and-O', 'sodium-B-Chemical', 'as-O', 'well-O', 'as-O', 'urinary-O', 'excretion-O', 'of-O', 'potassium-B-Chemical', ',-O', 'sodium-B-Chemical', 'and-O', 'aldosterone-B-Chemical', '.-O']
['L-Dopa-B-Chemical', 'intake-O', 'was-O', 'found-O', 'to-O', 'cause-O', 'an-O', 'increased-O', 'excretion-O', 'of-O', 'potassium-B-Chemical', ',-O', 'and-O', 'sometimes-O', 'also-O', 'of-O', 'sodium-B-Chemical', ',-O', 'in-O', 'the-O', 'hypokalemic-B-Disease', 'but-O', 'not-O', 'in-O', 'the-O', 'normokalemic-B-Disease', 'patients-O', '.-O']
['This-O', 'effect-O', 'on-O', 'the-O', 'renal-O', 'function-O', 'could-O', 'be-O', 'prohibited-O', 'by-O', 'the-O', 'administration-O', 'of-O', 'a-O', 'peripheral-O', 'dopa-B-Chemical', 'decarbodylase-O', 'inhibitor-O', '.-O']
['It-O', 'is-O', 'not-O', 'known-O', 'why-O', 'this-O', 'effect-O', 'occurred-O', 'in-O', 'some-O', 'individuals-O', 'but-O', 'not-O', 'in-O', 'others-O', ',-O', 'but-O', 'our-O', 'results-O', 'indicate-O', 'a-O', 'correlation-O', 'between-O', 'aldosterone-B-Chemical', 'production-O', 'and-O', 'this-O', 'renal-O', 'effect-O', 'of-O', 'L-dopa-B-Chemical']
['Phenytoin-B-Chemical', 'encephalopathy-B-Disease', 'as-O', 'probable-O', 'idiosyncratic-O', 'reaction-O', ':-O', 'case-O', 'report-O', '.-O']
['A-O', 'case-O', 'of-O', 'phenytoin-B-Chemical', '(-O', 'DPH-O', ')-O', 'encephalopathy-B-Disease', 'with-O', 'increasing-O', 'seizures-B-Disease', 'and-O', 'EEG-O', 'and-O', 'mental-O', 'changes-O', 'is-O', 'described-O', '.-O']
['Despite-O', 'adequate-O', 'oral-O', 'dosage-O', 'of-O', 'DPH-B-Chemical', '(-O', '5-O', 'mg-O', '/-O', 'kg-O', '/-O', 'daily-O', ')-O', 'the-O', 'plasma-O', 'level-O', 'was-O', 'very-O', 'low-O', '(-O', '2-O', '.-O']
['8-O', 'microgramg-O', '/-O', 'ml-O', ')-O', '.-O', 'The-O', 'encephalopathy-B-Disease', 'was-O', 'probably-O', 'an-O', 'idiosyncratic-O', 'and-O', 'not-O', 'toxic-O', 'or-O', 'allergic-B-Disease', 'reaction-I-Disease', '.-O']
['In-O', 'fact-O', 'the-O', 'concentration-O', 'of-O', 'free-O', 'DPH-B-Chemical', 'was-O', 'normal-O', ',-O', 'the-O', 'patient-O', 'presented-O', 'a-O', 'retarded-O', 'morbilliform-B-Disease', 'rash-O', 'during-O', 'DPH-B-Chemical', 'treatment-O', ',-O', 'the-O', 'protidogram-O', 'was-O', 'normal-O', ',-O', 'and-O', 'an-O', 'intradermic-O', 'DPH-B-Chemical', 'injection-O', 'had-O', 'no-O', 'local-O', 'effect-O', '.-O']
['The-O', 'authors-O', 'conclude-O', 'that-O', 'in-O', 'a-O', 'patient-O', 'starting-O', 'DPH-B-Chemical', 'treatment-O', 'an-O', 'unexpected-O', 'increase-O', 'in-O', 'seizures-B-Disease', ',-O', 'with-O', 'EEG-O', 'and-O', 'mental-O', 'changes-O', 'occurring-O', 'simultaneously-O', ',-O', 'should-O', 'alert-O', 'the-O', 'physician-O', 'to-O', 'the-O', 'possible-O', 'need-O', 'for-O', 'eliminating-O', 'DPH-B-Chemical']
['Effects-O', 'of-O', 'exercise-O', 'on-O', 'the-O', 'severity-O', 'of-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['The-O', 'effect-O', 'of-O', 'exercise-O', 'on-O', 'the-O', 'severity-O', 'of-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'was-O', 'studied-O', 'in-O', 'male-O', 'rats-O', '.-O']
['Ninety-O', ',-O', 'three-O', 'rats-O', 'were-O', 'randomly-O', 'divided-O', 'into-O', 'three-O', 'groups-O', '.-O']
['The-O', 'exercise-O', ',-O', 'isoproterenol-B-Chemical', '(-O', 'E-O', '-O', '1-O', ')-O', 'and-O', 'exercise-O', 'control-O', '(-O', 'EC-O', ')-O', 'groups-O', 'exercised-O', 'daily-O', 'for-O', 'thirty-O', 'days-O', 'on-O', 'a-O', 'treadmill-O', 'at-O', '1-O', 'mph-O', ',-O', '2-O', '%-O', 'grade-O', 'while-O', 'animals-O', 'of-O', 'the-O', 'sedentary-O', ',-O', 'isoproterenol-B-Chemical', '(-O', 'S-O', '-O', 'I-O', ')-O', 'group-O', 'remained-O', 'sedentary-O', '.-O']
['Eight-O', 'animals-O', 'were-O', 'assigned-O', 'to-O', 'the-O', 'sedentary-O', 'control-O', '(-O', 'SC-O', ')-O', 'group-O', 'which-O', 'remained-O', 'sedentary-O', 'throughout-O', 'the-O', 'experimental-O', 'period-O', '.-O']
['Forty-O', ',-O', 'eight-O', 'hours-O', 'after-O', 'the-O', 'final-O', 'exercise-O', 'period-O', ',-O', 'S-O', ',-O', 'I-O', 'and-O', 'E-O', ',-O', 'I-O', 'animals-O', 'received-O', 'a-O', 'single-O', 'subcutaneous-O', 'injection-O', 'of-O', 'isoproterenol-B-Chemical', '(-O', '250-O', 'mg-O', '/-O', 'kg-O', 'body-O', 'weight-O', ').-O', 'Animals-O', 'of-O', 'the-O', 'S-O', ',-O', 'I-O', 'group-O', 'exhibited-O', 'significantly-O', '(-O', 'Pp-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ')-O', 'greater-O', 'mortality-O', 'from-O', 'the-O', 'effects-O', 'of-O', 'isoproterenol-B-Chemical', 'than-O', 'animals-O', 'of-O', 'the-O', 'E-O', ',', 'I-O', 'group-O', '.-O']
['Serum-O', 'CPK-B-Chemical', 'activity-O', 'for-O', 'E-O', ',-O', 'I-O', 'animals-O', 'was-O', 'significantly-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ')-O', 'greater-O', 'than-O', 'for-O', 'animals-O', 'in-O', 'the-O', 'S-O', ',-O', 'I-O', 'and-O', 'EC-O', 'groups-O', 'twenty-O', 'hours-O', 'following-O', 'isoproterenol-B-Chemical', 'injection-O', '.-O']
['No-O', 'statistically-O', 'significant-O', 'differences-O', 'were-O', 'observed-O', 'between-O', 'the-O', 'two-O', 'isoproterenol-B-Chemical', 'treated-O', 'groups-O', 'for-O', 'severity-O', 'of-O', 'the-O', 'induced-O', 'lesions-O', ',-O', 'changes-O', 'in-O', 'heart-O', 'weight-O', ',-O', 'or-O', 'heart-O', 'weight-O', 'to-O', 'body-O', 'weight-O', 'ratios-O', '.-O']
['The-O', 'results-O', 'indicated-O', 'that-O', 'exercise-O', 'reduced-O', 'the-O', 'mortality-O', 'associated-O', 'with-O', 'the-O', 'effects-O', 'of-O', 'large-O', 'dosages-O', 'of-O', 'isoproterenol-B-Chemical', 'but-O', 'had-O', 'little-O', 'on-O', 'the-O', 'severity-O', 'of-O', 'the-O', 'infarction-O']
['Effect-O', 'of-O', 'D-Glucarates-B-Chemical', 'on-O', 'basic-O', 'antibiotic-O', ',-O', 'induced-O', 'renal-B-Disease', 'damage-I-Disease', 'in-O', 'rats-O', '.-O']
['Dehydrated-O', 'rats-O', 'regularly-O', 'develop-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'following-O', 'single-O', 'injection-O', 'of-O', 'aminoglycoside-B-Chemical', 'antibiotics-O', 'combined-O', 'with-O', 'dextran-B-Chemical', 'or-O', 'of-O', 'antibiotics-O', 'only-O', '.-O']
['Oral-O', 'administration-O', 'of-O', '2,5-di-O-acetyl-D-glucaro-1,4-6,3-dilactone-B-Chemical', 'protected-O', 'rats-O', 'against-O', 'renal-B-Disease', 'failure-I-Disease', 'induced-O', 'by-O', 'kanamycin-B-Chemical', ',-O', 'dextran-B-Chemical', '.-O']
['The-O', 'protective-O', 'effect-O', 'was-O', 'prevalent-O', 'among-O', 'D-glucarates-B-Chemical', ',-O', 'and-O', 'also-O', 'to-O', 'other-O', 'saccharic-O', 'acid-B-Chemical', ',-O', 'hexauronic-O', 'acids-B-Chemical', 'and-O', 'hexaaldonic-O', 'acids-B-Chemical', ',-O', 'although-O', 'to-O', 'a-O', 'lesser-O', 'degree-O', ',-O', 'but-O', 'not-O', 'to-O', 'a-O', 'hexaaldose-B-Chemical', ',-O', 'sugar-O', 'alcohols-O', ',-O', 'substances-O', 'inthe-O', 'TCA-O', 'cycle-O', 'and-O', 'other-O', 'acidic-O', 'compounds-O', '.-O']
['D-Glucarates-B-Chemical', 'were-O', 'effective-O', 'against-O', 'renal-B-Disease', 'damage-I-Disease', 'induced-O', 'by-O', 'peptide-O', 'antibiotics-O', 'as-O', 'well-O', 'as-O', 'various-O', 'aminoglycoside-B-Chemical', 'antibitocis-O', '.-O']
['Dose-O', ',-O', 'responses-O', 'were-O', 'observed-O', 'in-O', 'the-O', 'protective-O', 'effect-O', 'of-O', 'D-Glucarates-B-Chemical', '.-O']
['With-O', 'a-O', 'D-glucarate-B-Chemical', 'of-O', 'a-O', 'fixed-O', 'size-O', 'of-O', 'dose-O', ',-O', 'approximately-O', 'the-O', 'same-O', 'degree-O', 'of-O', 'protection-O', 'was-O', 'obtained-O', 'against-O', 'renal-B-Disease', 'damages-I-Disease', 'induced-O', 'by-O', 'different-O', 'basic-O', 'antibiotics-O', 'despite-O', 'large-O', 'disparities-O', 'in-O', 'administration-O', 'doses-O', 'of-O', 'different-O', 'antibiotics-O', '.-O']
['D-Glucarates-B-Chemical', 'had-O', 'the-O', 'ability-O', 'to-O', 'prevent-O', 'renal-B-Disease', 'damage-I-Disease', 'but-O', 'not-O', 'to-O', 'cure-O', 'it-O', '.-O']
['Rats-O', 'excreted-O', 'acidic-O', 'urine-O', 'when-O', 'they-O', 'were-O', 'spared-O', 'from-O', 'renal-B-Disease', 'lesions-I-Disease', 'by-O', 'monosaccharides-B-Chemical', '.-O']
['The-O', 'reduction-O', 'effect-O', 'of-O', 'D-glucarates-B-Chemical', 'against-O', 'nephrotoxicity-B-Disease']
['Paraplegia-B-Disease', 'following-O', 'intrathecal-O', 'methotrexate-B-Chemical', ':-O', 'report-O', 'of-O', 'a-O', 'case-O', 'and-O', 'review-O', 'of-O', 'the-O', 'literature-O', '.-O']
['A-O', 'patient-O', 'who-O', 'developed-O', 'paraplegia-B-Disease', 'following-O', 'the-O', 'intrathecal-O', 'instillation-O', 'of-O', 'methotrexate-B-Chemical', 'is-O', 'discribed-O', '.-O']
['The-O', 'ten-O', 'previously-O', 'reported-O', 'cases-O', 'of-O', 'this-O', 'unusual-O', 'complication-O', 'are-O', 'reviewed-O', '.-O']
['The-O', 'following-O', 'factors-O', 'appear-O', 'to-O', 'predispose-O', 'to-O', 'the-O', 'development-O', 'of-O', 'this-O', 'complication-O', ':', 'abnormal-O', 'cerebrospinal-O', 'dynamics-O', 'related-O', 'to-O', 'the-O', 'presence-O', 'of-O', 'central-O', 'nervous-O', 'system-O', 'leukemia-B-Disease', ',', 'and-O', 'epidural-O', 'cerebrospinal-O', 'leakage-O', ';', 'elevated-O', 'cerebrospinal-O', 'fluid-O', 'methothexate-B-Chemical', 'concentration-O', 'related-O', 'to-O', 'abnormal-O', 'cerebrospinal-O', 'fluid-O', 'dynamics-O', 'and-O', 'to-O', 'inappropriately-O', 'high-O', 'methotrexate-B-Chemical', 'doses-O', 'based-O', 'on-O', 'body-O', 'surface-O', 'area-O', 'calculations-O', 'in-O', 'older-O', 'children-O', 'and-O', 'adults-O', ';', 'the-O', 'presence-O', 'of-O', 'neurotoxic-B-Disease', 'preservatives-O', 'in-O', 'commercially-O', 'available-O', 'methotrexate-B-Chemical', 'preparations-O', 'and-O', 'diluents-O', ';', 'and-O', 'the-O', 'use-O', 'of-O', 'methotrexate-B-Chemical', 'diluents-O', 'of-O', 'unphysiologic-O', 'pH-O', ',', 'ionic-O', 'content-O', 'and-O', 'osmolarity-O', '.-O']
['The-O', 'role-O', 'of-O', 'methotrexate-B-Chemical', 'contaminants-O', ',-O', 'local-O', 'folate-B-Chemical', 'deficiency-O', ',-O', 'and-O', 'cranial-O', 'irradiation-O', 'in-O', 'the-O', 'pathogenesis-O', 'of-O', 'intrathecal-O', 'methotrexate-B-Chemical', 'toxicity-B-Disease', 'is-O', 'unclear-O', '.-O']
['The-O', 'incidence-O', 'of-O', 'neurotoxicity-B-Disease', 'may-O', 'be-O', 'reduced-O', 'by-O', 'employing-O', 'lower-O', 'doses-O', 'of-O', 'methotrexate-B-Chemical', 'in-O', 'the-O', 'presence-O', 'of-O', 'central-O', 'nervous-O', 'system-O', 'leukemia-B-Disease', ',-O', 'in-O', 'older-O', 'children-O', 'and-O', 'adults-O', ',-O', 'and-O', 'in-O', 'the-O', 'presence-O', 'of-O', 'epidural-O', 'leakage-O', '.-O']
['Only-O', 'preservative-O', ',-O', 'free-O', 'methotrexate-B-Chemical', 'in-O', 'Elliott-O', 'x-O', 's-O', 'B-O', 'Solution-O', 'at-O', 'a-O', 'concentration-O', 'of-O', 'not-O', 'more-O', 'than-O', '1-O', 'mg-O', '/-O', 'ml-O', 'should-O', 'be-O', 'used-O', 'for-O', 'intrathecal-O', 'administration-O', '.-O']
['Periodic-O', 'monitoring-O', 'of-O', 'cerebruspinal-O', 'fluid-O', 'methotrexate-B-Chemical', 'levels-O', 'may-O', 'be-O', 'predictive-O', 'of-O', 'the-O', 'development-O', 'of-O', 'serious-O', 'neurotoxicity-B-Disease']
['Centrally-O', 'mediated-O', 'cardiovascular-O', 'effects-O', 'of-O', 'intracisternal-O', 'application-O', 'of-O', 'carbachol-B-Chemical', 'in-O', 'anesthetized-O', 'rats-O', '.-O']
['The-O', 'pressor-O', 'response-O', 'to-O', 'the-O', 'intracisternal-O', '(-O', 'i-O', '.-O']
['c-O', ')-O', 'injection-O', 'of-O', 'carbachol-B-Chemical', '(-O', '1-O', 'mug-O', ')-O', 'in-O', 'anesthetized-O', 'rats-O', 'was-O', 'analyzed-O', '.-O']
['This-O', 'response-O', 'was-O', 'significantly-O', 'reduced-O', 'by-O', 'the-O', 'intravenous-O', '(-O', 'i-O', '.-O']
['v-O', ')-O', 'injection-O', 'of-O', 'guanethidine-B-Chemical', '(-O', '5-O', 'mg-O', ')-O', 'hexamethonium-B-Chemical', '(-O', '10-O', 'mg-O', ')-O', 'or-O', 'phentolamine-B-Chemical', '(-O', '5-O', 'mg-O', ')-O', 'and-O', 'conversely-O', ',-O', 'potentiated-O', 'by-O', 'i-O', '.-O']
['v-O', '.-O']
['desmethylimipramine-B-Chemical', '(-O', '0-O', '.-O']
['3-O', 'mg-O', ')-O', 'while-O', 'propranolol-B-Chemical', '(-O', '0-O', '.-O']
['5-O', 'mg-O', ')-O', 'i-O', '.-O']
['v-O', '.-O']
['selectively-O', 'inhibited-O', 'the-O', 'enlargement-O', 'of-O', 'pulse-O', 'pressure-O', 'and-O', 'the-O', 'tachycardia-B-Disease', 'following-O', 'i-O', '.-O']
['c-O', '.-O']
['carbachol-B-Chemical', '(-O', '1-O', 'mug-O', ').-O', 'On-O', 'the-O', 'other-O', 'hand-O', ',-O', 'the-O', 'pressor-O', 'response-O', 'to-O', 'i-O', '.-O']
['c-O', '.-O']
['carbachol-B-Chemical', '(-O', '1-O', 'mug-O', ')-O', 'was-O', 'almost-O', 'completely-O', 'blocked-O', 'by-O', 'i-O', '.-O']
['c-O', '.-O']
['atropine-B-Chemical', '(-O', '3-O', 'mug-O', ')-O', 'or-O', 'hexamethonium-B-Chemical', '(-O', '500-O', 'mug-O', ')-O', ',', 'and-O', 'significantly-O', 'reduced-O', 'by-O', 'i-O', '.-O']
['c-O', '.-O']
['chlorpromazine-B-Chemical', '(-O', '50-O', 'mug-O', ')-O', 'but-O', 'significantly-O', 'potentiated-O', 'by-O', 'i-O']
['c-O', '.-O']
['desmethylimipramine-B-Chemical', '(-O', '30-O', 'mug-O', ').-O', 'The-O', 'pressor-O', 'response-O', 'to-O', 'i-O', '.-O']
['c-O', '.-O']
['carbachol-B-Chemical', '(-O', '1-O', 'mug-O', ')-O', 'remained-O', 'unchanged-O', 'after-O', 'sectioning-O', 'of-O', 'the-O', 'bilateral-O', 'cervical-O', 'vagal-O', 'nerves-O', 'but-O', 'disappeared-O', 'after-O', 'sectioning-O', 'of-O', 'the-O', 'spinal-O', 'cord-O', '(-O', 'C7-O', ',-O', 'C8-O', ')-O', '.-O', 'From-O', 'the-O', 'above-O', 'result-O', 'it-O', 'is-O', 'suggested-O', 'that-O', 'the-O', 'pressor-O', 'response-O', 'to-O', 'i-O', '.-O']
['c-O', '.-O']
['carbachol-B-Chemical']
['Hyperglycemic-O', 'effect-O', 'of-O', 'amino-B-Chemical', 'compounds-O', 'structurally-O', 'related-O', 'to-O', 'caproate-B-Chemical', 'in-O', 'rats-O', '.-O']
['The-O', 'chronic-O', 'feeding-O', 'of-O', 'small-O', 'amounts-O', '(-O', '0-O', '.-O']
['3-O', ',', '3-O', '%-O', 'of-O', 'diet-O', 'weight-O', ')-O', 'of-O', 'certain-O', 'amino-O', 'derivatives-O', 'of-O', 'caproate-B-Chemical', 'resulted-O', 'in-O', 'hyperglycemia-B-Disease', ',', 'an-O', 'elevated-O', 'glucose-B-Chemical', 'tolerance-O', 'curve-O', 'and-O', ',', 'occasionally-O', ',', 'glucosuria-B-Disease', '.-O']
['Effective-O', 'compounds-O', 'included-O', 'norleucine-B-Chemical', ',-O', 'norvaline-B-Chemical', ',-O', 'glutamate-B-Chemical', ',-O', 'epsilon-aminocaproate-B-Chemical', ',-O', 'methionine-B-Chemical', ',-O', 'and-O', 'leucine-B-Chemical']
['Fatty-B-Disease', 'liver-I-Disease', 'induced-O', 'by-O', 'tetracycline-B-Chemical', 'in-O', 'the-O', 'rat-O', '.-O']
['Dose-O', ',-O', 'response-O', 'relationships-O', 'and-O', 'effect-O', 'of-O', 'sex-O', '.-O']
['Dose-O', ',-O', 'response-O', 'relationships-O', ',-O', 'biochemical-O', 'mechanisms-O', ',-O', 'and-O', 'sex-O', 'differences-O', 'in-O', 'the-O', 'experimental-O', 'fatty-O', 'liver-B-Disease', 'induced-O', 'by-O', 'tetracycline-B-Chemical', 'were-O', 'studied-O', 'in-O', 'the-O', 'intact-O', 'rat-O', 'and-O', 'with-O', 'the-O', 'isolated-O', 'perfused-O', 'rat-O', 'liver-O', 'in-O', 'vitro-O', '.-O']
['In-O', 'the-O', 'intact-O', 'male-O', 'and-O', 'female-O', 'rat-O', ',-O', 'no-O', 'direct-O', 'relationship-O', 'was-O', 'observed-O', 'between-O', 'dose-O', 'of-O', 'tetracycline-B-Chemical', 'and-O', 'hepatic-O', 'accumulation-O', 'of-O', 'triglyceride-B-Chemical', '.-O']
['With-O', 'provision-O', 'of-O', 'adequate-O', 'oleic-B-Chemical', 'acid-B-Chemical', 'as-O', 'a-O', 'substrate-O', 'for-O', 'the-O', 'isolated-O', 'perfused-O', 'liver-O', ',-O', 'a-O', 'direct-O', 'relationship-O', 'was-O', 'observed-O', 'between-O', 'dose-O', 'of-O', 'tetracycline-B-Chemical', 'and-O', 'both-O', 'accumulation-O', 'of-O', 'triglyceride-B-Chemical', 'in-O', 'the-O', 'liver-O', 'and-O', 'depression-O', 'of-O', 'output-O', 'of-O', 'triglyceride-B-Chemical', 'by-O', 'livers-O', 'from-O', 'male-O', 'and-O', 'female-O', 'rats-O', '.-O']
['Marked-O', 'differences-O', 'were-O', 'observed-O', 'between-O', 'female-O', 'and-O', 'male-O', 'rats-O', 'with-O', 'regard-O', 'to-O', 'base-O', 'line-O', '(-O', 'control-O', ')-O', 'hepatic-O', 'concentration-O', 'of-O', 'triglyceride-B-Chemical', 'and-O', 'output-O', 'of-O', 'triglyceride-B-Chemical', '.-O']
['Accumulation-O', 'of-O', 'hepatic-O', 'triglyceride-O', ',-O', 'as-O', 'a-O', 'per-O', 'cent-O', 'of-O', 'control-O', 'values-O', ',-O', 'in-O', 'response-O', 'to-O', 'graded-O', 'doses-O', 'of-O', 'tetracycline-B-Chemical', ',-O', 'did-O', 'not-O', 'differ-O', 'significantly-O', 'between-O', 'male-O', ',-O', 'female-O', 'and-O', 'pregnant-O', 'rat-O', 'livers-O', '.-O']
['However-O', ',-O', 'livers-O', 'from-O', 'female-O', ',-O', 'and-O', 'especially-O', 'pregnant-O', 'female-O', 'rats-O', ',-O', 'were-O', 'strikingly-O', 'resistant-O', 'to-O', 'the-O', 'effects-O', 'of-O', 'tetracycline-B-Chemical', 'on-O', 'depression-B-Disease', 'of-O', 'output-O', 'of-O', 'triglyceride-O', 'under-O', 'these-O', 'experimental-O', 'conditions-O', '.-O']
['These-O', 'differences-O', 'between-O', 'the-O', 'sexes-O', 'could-O', 'not-O', 'be-O', 'related-O', 'to-O', 'altered-O', 'disposition-O', 'of-O', 'tetracycline-B-Chemical', 'or-O', 'altered-O', 'uptake-O', 'of-O', 'oleic-B-Chemical', 'acid-O', '.-O']
['Depressed-O', 'hepatic-B-Disease', 'secretion-O', 'of-O', 'triglyceride-B-Chemical', 'accounted-O', 'only-O', 'for-O', '30-O', 'to-O', '50-O', '%-O', 'of-O', 'accumulated-O', 'hepatic-B-Disease', 'triglyceride-B-Chemical', ',-O', 'indicating-O', 'that-O', 'additional-O', 'mechanisms-O', 'must-O', 'be-O', 'involved-O', 'in-O', 'the-O', 'production-O', 'of-O', 'the-O', 'triglyceride-B-Chemical', ',-O', 'rich-O', 'fatty-O', 'liver-B-Disease', 'in-O', 'response-O', 'to-O', 'tetracycline-B-Chemical']
['Fatal-O', 'myeloencephalopathy-B-Disease', 'due-O', 'to-O', 'intrathecal-O', 'vincristine-B-Chemical', 'administration-O', '.-O']
['Vincristine-B-Chemical', 'was-O', 'accidentally-O', 'given-O', 'intrathecally-O', 'to-O', 'a-O', 'child-O', 'with-O', 'leukaemia-B-Disease', ',-O', 'producing-O', 'sensory-O', 'and-O', 'motor-O', 'dysfunction-O', 'followed-O', 'by-O', 'encephalopathy-B-Disease', 'and-O', 'death-B-Disease', '.-O']
['Separate-O', 'times-O', 'for-O', 'administering-O', 'vincristine-B-Chemical']
['Progesterone-B-Chemical', 'potentiation-O', 'of-O', 'bupivacaine-B-Chemical', 'arrhythmogenicity-O', 'in-O', 'pentobarbital-B-Chemical', ',-O', 'anesthetized-O', 'rats-O', 'and-O', 'beating-O', 'rat-O', 'heart-O', 'cell-O', 'cultures-O', '.-O']
['The-O', 'effects-O', 'of-O', 'progesterone-B-Chemical', 'treatment-O', 'on-O', 'bupivacaine-B-Chemical', 'arrhythmogenicity-O', 'in-O', 'beating-O', 'rat-O', 'heart-O', 'myocyte-O', 'cultures-O', 'and-O', 'on-O', 'anesthetized-O', 'rats-O', 'were-O', 'determined-O', '.-O']
['After-O', 'determining-O', 'the-O', 'bupivacaine-B-Chemical', 'AD50-O', '(-O', 'the-O', 'concentration-O', 'of-O', 'bupivacaine-B-Chemical', 'that-O', 'caused-O', '50-O', '%-O', 'of-O', 'all-O', 'beating-O', 'rat-O', 'heart-O', 'myocyte-O', 'cultures-O', 'to-O', 'become-O', 'arrhythmic-O', '),-O', 'we-O', 'determined-O', 'the-O', 'effect-O', 'of-O', '1-O', '-O', 'hour-O', 'progesterone-B-Chemical', 'HCl-I-Chemical', 'exposure-O', 'on-O', 'myocyte-O', 'contractile-O', 'rhythm-O', '.-O']
['Each-O', 'concentration-O', 'of-O', 'progesterone-B-Chemical', '(-O', '6-O', '.-O']
['25-O', ',-O', '12-O', '.-O']
['5-O', ',-O', '25-O', ',-O', 'and-O', '50-O', 'micrograms-O', '/-O', 'ml-O', ')-O', 'caused-O', 'a-O', 'significant-O', 'and-O', 'concentration-O', ',-O', 'dependent-O', 'reduction-O', 'in-O', 'the-O', 'AD50-O', 'for-O', 'bupivacaine-B-Chemical', '.-O']
['Estradiol-B-Chemical', 'treatment-O', 'also-O', 'increased-O', 'the-O', 'arrhythmogenicity-O', 'of-O', 'bupivacaine-B-Chemical', 'in-O', 'myocyte-O', 'cultures-O', ',-O', 'but-O', 'was-O', 'only-O', 'one-O', 'fourth-O', 'as-O', 'potent-O', 'as-O', 'progesterone-B-Chemical', '.-O']
['Neither-O', 'progesterone-B-Chemical', 'nor-O', 'estradiol-B-Chemical', 'effects-O', 'on-O', 'bupivacaine-B-Chemical', 'arrhythmogenicity-B-Disease', 'were-O', 'potentiated-O', 'by-O', 'epinephrine-B-Chemical', '.-O']
['Chronic-O', 'progesterone-B-Chemical', 'pretreatment-O', '(-O', '5-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', 'for-O', '21-O', 'days-O', ')-O', 'caused-O', 'a-O', 'significant-O', 'increase-O', 'in-O', 'bupivacaine-B-Chemical', 'arrhythmogenicity-B-Disease', 'in-O', 'intact-O', 'pentobarbital-B-Chemical', ',-O', 'anesthetized-O', 'rats-O', '.-O']
['There-O', 'was-O', 'a-O', 'significant-O', 'decrease-O', 'in-O', 'the-O', 'time-O', 'to-O', 'onset-O', 'of-O', 'arrhythmia-B-Disease', 'as-O', 'compared-O', 'with-O', 'control-O', 'nonprogesterone-B-Chemical', ',-O', 'treated-O', 'rats-O', '(-O', '6-O', '.-O']
['2-O', '+-O', '1-O', '.-O']
['3-O', 'vs-O', '.-O']
['30-O', '.-O']
['8-O', '+-O', '2-O', '.-O']
['5-O', 'min-O', ',-O', 'mean-O', '+-O', 'SE-O', ')-O', '.-O', 'The-O', 'results-O', 'of-O', 'this-O', 'study-O', 'indicate-O', 'that-O', 'progesterone-B-Chemical', 'can-O', 'potentiate-O', 'bupivacaine-B-Chemical', 'arrhythmogenicity-B-Disease', 'both-O', 'in-O', 'vivo-O', 'and-O', 'in-O', 'vitro-O', '.-O']
['Potentiation-O', 'of-O', 'bupivacaine-B-Chemical', 'arrhythmia-B-Disease']
['Acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'occurring-O', 'during-O', 'intravenous-O', 'desferrioxamine-B-Chemical', 'therapy-O', ':-O', 'recovery-O', 'after-O', 'haemodialysis-O', '.-O']
['A-O', 'patient-O', 'with-O', 'transfusion-O', 'dependent-O', 'thalassemia-B-Disease', 'was-O', 'undergoing-O', 'home-O', 'intravenous-O', 'desferrioxamine-B-Chemical', '(-O', 'DFX-B-Chemical', ')-O', 'treatment-O', 'by-O', 'means-O', 'of-O', 'a-O', 'totally-O', 'implanted-O', 'system-O', 'because-O', 'of-O', 'his-O', 'poor-O', 'compliance-O', 'with-O', 'the-O', 'nightly-O', 'subcutaneous-O', 'therapy-O', '.-O']
['Due-O', 'to-O', 'an-O', 'accidental-O', 'malfunctioning-O', 'of-O', 'the-O', 'infusion-O', 'pump-O', ',-O', 'the-O', 'patient-O', 'was-O', 'inadvertently-O', 'administered-O', 'a-O', 'toxic-O', 'dosage-O', 'of-O', 'the-O', 'drug-O', 'which-O', 'caused-O', 'renal-B-Disease', 'insufficiency-I-Disease', '.-O']
['Given-O', 'the-O', 'progressive-O', 'deterioration-O', 'of-O', 'the-O', 'symptoms-O', 'and-O', 'of-O', 'the-O', 'laboratory-O', 'values-O', ',-O', 'despite-O', 'adequate-O', 'medical-O', 'treatment-O', ',-O', 'a-O', 'decision-O', 'was-O', 'made-O', 'to-O', 'introduce-O', 'haemodialytical-O', 'therapy-O', 'in-O', 'order-O', 'to-O', 'remove-O', 'the-O', 'drug-O', 'and-O', 'therapy-O', 'reduce-O', 'the-O', 'nephrotoxicity-B-Disease', '.-O']
['From-O', 'the-O', 'results-O', 'obtained-O', ',-O', 'haemodialysis-O', 'can-O', 'therefore-O', 'be-O', 'suggested-O', 'as-O', 'a-O', 'useful-O', 'therapy-O', 'in-O', 'rare-O', 'cases-O', 'of-O', 'progressive-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'caused-O', 'by-O', 'desferrioxamine-B-Chemical']
['Neuroleptic-O', ',-O', 'associated-O', 'hyperprolactinemia-B-Disease', '.-O']
['Can-O', 'it-O', 'be-O', 'treated-O', 'with-O', 'bromocriptine-B-Chemical', '?-O', 'Six-O', 'stable-O', 'psychiatric-O', 'outpatients-O', 'with-O', 'hyperprolactinemia-B-Disease', 'and-O', 'amenorrhea-O', '/-O', 'oligomenorrhea-O', 'associated-O', 'with-O', 'their-O', 'neuroleptic-O', 'medications-O', 'were-O', 'treated-O', 'with-O', 'bromocriptine-B-Chemical', '.-O']
['Daily-O', 'dosages-O', 'of-O', '5-O', ',-O', '10-O', 'mg-O', 'corrected-O', 'the-O', 'hyperprolactinemia-B-Disease', 'and-O', 'restored-O', 'menstruation-O', 'in-O', 'four-O', 'of-O', 'the-O', 'six-O', 'patients-O', '.-O']
['One-O', 'woman-O', ',-O', 'however-O', ',-O', 'developed-O', 'worsened-O', 'psychiatric-B-Disease', 'symptoms-O', 'while-O', 'taking-O', 'bromocriptine-B-Chemical', ',-O', 'and-O', 'it-O', 'was-O', 'discontinued-O', '.-O']
['Thus-O', ',-O', 'three-O', 'of-O', 'six-O', 'patients-O', 'had-O', 'their-O', 'menstrual-O', 'irregularity-B-Disease', 'successfully-O', 'corrected-O', 'with-O', 'bromocriptine-B-Chemical', '.-O']
['This-O', 'suggests-O', 'that-O', 'bromocriptine-B-Chemical', 'should-O', 'be-O', 'further-O', 'evaluated-O', 'as-O', 'potential-O', 'therapy-O', 'for-O', 'neuroleptic-O', ',-O', 'associated-O', 'hyperprolactinemia-B-Disease', 'and-O', 'amenorrhea-B-Disease', '/-O', 'galactorrhea-B-Disease']
['Ethacrynic-B-Chemical', 'acid-I-Chemical', ',-O', 'induced-O', 'convulsions-B-Disease', 'and-O', 'brain-O', 'neurotransmitters-O', 'in-O', 'mice-O', '.-O']
['Intracerebroventricular-O', 'injection-O', 'of-O', 'ethacrynic-B-Chemical', 'acid-I-Chemical', '(-O', '50-O', '%-O', 'convulsive-O', 'dose-O', ';-O', '50-O', 'micrograms-O', '/-O', 'mouse-O', ')-O', 'accelerated-O', 'the-O', 'synthesis-O', '/-O', 'turnover-O', 'of-O', '5-hydroxytryptamine-B-Chemical', '(-O', '5-HT-B-Chemical', ')-O', 'but-O', 'suppressed-O', 'the-O', 'synthesis-O', 'of-O', 'gamma-aminobutyric-B-Chemical', 'acid-I-Chemical', 'and-O', 'acetylcholine-B-Chemical', 'in-O', 'mouse-O', 'brain-O', '.-O']
['These-O', 'effects-O', 'were-O', 'completely-O', 'antagonized-O', 'by-O', 'pretreatment-O', 'with-O', 'a-O', 'glutamate-B-Chemical', '/-O', 'N-methyl-D-aspartate-B-Chemical', 'antagonist-O', ',-O', 'aminophosphonovaleric-B-Chemical', 'acid-I-Chemical', '.-O']
['In-O', 'ethacrynic-B-Chemical', 'acid-I-Chemical', ',-O', 'induced-O', 'convulsions-B-Disease']
['Pharmacology-O', 'of-O', 'gamma-aminobutyric-B-Chemical', 'acid-I-Chemical', 'A-O', 'receptor-O', 'complex-O', 'after-O', 'the-O', 'in-O', 'vivo-O', 'administration-O', 'of-O', 'the-O', 'anxioselective-O', 'and-O', 'anticonvulsant-O', 'beta-carboline-B-Chemical', 'derivative-O', 'abecarnil-B-Chemical', '.-O']
['In-O', 'rodents-O', ',-O', 'the-O', 'effect-O', 'of-O', 'the-O', 'beta-carboline-B-Chemical', 'derivative-O', 'isopropyl-6-B-Chemical', '-O', 'benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate-B-Chemical', '(-O', 'abecarrnil-B-Chemical', ')-O', 'a-O', 'new-O', 'ligand-O', 'for-O', 'benzodiazepine-B-Chemical', 'receptors-O', 'possessing-O', 'anxiolytic-O', 'and-O', 'anticonvulsant-O', 'properties-O', ',-O', 'was-O', 'evaluated-O', 'on-O', 'the-O', 'function-O', 'of-O', 'central-O', 'gamma-aminobutyric-B-Chemical', 'acid-O', '(-O', 'GABA-B-Chemical', ')', 'A-O', 'receptor-O', 'complex-O', ',-O', 'both-O', 'in-O', 'vitro-O', 'and-O', 'in-O', 'vivo-O', '.-O']
['Added-O', 'in-O', 'vitro-O', 'to-O', 'rat-O', 'cortical-O', 'membrane-O', 'preparation-O', ',-O', 'abecarnil-B-Chemical', 'increased-O', '[', '3H-O', ']-O', 'GABA-B-Chemical', 'binding-O', ',-O', 'enhanced-O', 'muscimol-B-Chemical', ',-O', 'stimulated-O', '36Cl-B-Chemical', ',-O', 'uptake-O', 'and-O', 'reduced-O', 'the-O', 'binding-O', 'of-O', 't-[35S]butylbicyclophosphorothionate-B-Chemical', '(-O', '[35S]TBPS-B-Chemical', ')-O', '.-O', 'These-O', 'effects-O', 'were-O', 'similar-O', 'to-O', 'those-O', 'induced-O', 'by-O', 'diazepam-B-Chemical', ',-O', 'whereas-O', 'the-O', 'partial-O', 'agonist-O', 'Ro-O', '16-6028-B-Chemical', '(-O', 'tert-butyl-(S)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-I-Chemical', '-imidazo[1,5-a]-pyrrolo-[2,1-c1,4]benzodiazepine-1-carboxylate-I-Chemical', ')-O', 'showed-O', 'very-O', 'weak-O', 'efficacy-O', 'in-O', 'these-O', 'biochemical-O', 'tests-O', '.-O']
['After-O', 'i-O', '.-O']
['p-O', '.-O']
['injection-O', 'to-O', 'rats-O', ',-O', 'abecarnil-B-Chemical', 'and-O', 'diazepam-B-Chemical', 'decreased-O', 'in-O', 'a-O', 'time-O', ',-O', 'dependent-O', 'and-O', 'dose-O', ',-O', 'related-O', '(-O', '0-O', '.-O']
['25-O', ',-O', '20-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', ')-O', 'manner-O', '[35S]TBPS-B-Chemical', 'binding-O', 'measured-O', 'ex-O', 'vivo-O', 'in-O', 'the-O', 'cerebral-O', 'cortex-O', '.-O']
['Moreover-O', ',-O', 'both-O', 'drugs-O', 'at-O', 'the-O', 'dose-O', 'of-O', '0-O', '.-O']
['5-O', 'mg-O', '/-O', 'kg-O', 'antagonized-O', 'completely-O', 'the-O', 'convulsant-O', 'activity-O', 'and-O', 'the-O', 'increase-O', 'of-O', '[35S]TBPS-O', 'binding-O', 'induced-O', 'by-O', 'isoniazide-B-Chemical', '(-O', '350-O', 'mg-O', '/-O', 'kg-O', 's-O', '.-O']
['c-O', ')-O', 'as-O', 'well-O', 'as-O', 'the-O', 'increase-O', 'of-O', '[35S]TBPS-B-Chemical', 'binding-O', 'induced-O', 'by-O', 'foot-O', 'shock-O', 'stress-B-Disease', '.-O']
['To-O', 'better-O', 'correlate-O', 'the-O', 'biochemical-O', 'and-O', 'the-O', 'pharmacological-O', 'effects-O', ',-O', 'we-O', 'studied-O', 'the-O', 'action-O', 'of-O', 'abecarnil-B-Chemical', 'on-O', '[35S]TBPS-B-Chemical', 'binding-O', ',-O', 'exploratory-O', 'motility-O', 'and-O', 'on-O', 'isoniazid-B-Chemical', ',-O', 'induced-O', 'biochemical-O', 'and-O', 'pharmacological-O', 'effects-O', 'in-O', 'mice-O', '.-O']
['In-O', 'these-O', 'animals-O', ',-O', 'abecarnil-B-Chemical', 'produced-O', 'a-O', 'paralleled-O', 'dose-O', ',-O', 'dependent-O', '(-O', '0-O', '.-O']
['05-O', ',-O', '1-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', ')-O', 'reduction-O', 'of-O', 'both-O', 'motor-O', 'behavior-O', 'and-O', 'cortical-O', '[-O', '35S-B-Chemical', ']-O', 'TBPS-B-Chemical', 'binding-O', '.-O']
['Moreover-O', ',-O', '0-O', '.-O']
['05-O', 'mg-O', '/-O', 'kg-O', 'of-O', 'this-O', 'beta-carboline-B-Chemical', 'reduced-O', 'markedly-O', 'the-O', 'increase-O', 'of-O', '[35S]TBPS-B-Chemical', 'binding-O', 'and-O', 'the-O', 'convulsions-B-Disease', 'induced-O', 'by-O', 'isoniazid-B-Chemical']
['Recurrent-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'in-O', 'a-O', 'postpartum-O', 'patient-O', 'receiving-O', 'bromocriptine-B-Chemical', '.-O']
['Myocardial-B-Disease', 'infarction-I-Disease', 'in-O', 'puerperium-O', 'is-O', 'infrequently-O', 'reported-O', '.-O']
['Spasm-B-Disease', ',-O', 'coronary-O', 'dissection-I-Disease', ',-O', 'or-O', 'atheromatous-O', 'etiology-O', 'has-O', 'been-O', 'described-O', '.-O']
['Bromocriptine-B-Chemical', 'has-O', 'been-O', 'implicated-O', 'in-O', 'several-O', 'previous-O', 'case-O', 'reports-O', 'of-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'in-O', 'the-O', 'puerperium-O', '.-O']
['Our-O', 'case-O', '(-O', 'including-O', 'an-O', 'inadvertent-O', 'rechallenge-O', ')', 'suggests-O', 'such-O', 'a-O', 'relationship-O', '.-O']
['Although-O', 'generally-O', 'regarded-O', 'as-O', 'x-O', 'safe-O', ',-O', 'possible-O', 'serious-O', 'cardiac-O', 'effects-O', 'of-O', 'bromocriptine-B-Chemical']
['Asterixis-B-Disease', 'induced-O', 'by-O', 'carbamazepine-B-Chemical', 'therapy-O', '.-O']
['There-O', 'are-O', 'very-O', 'few-O', 'reports-O', 'about-O', 'asterixis-B-Disease', 'as-O', 'a-O', 'side-O', 'effect-O', 'of-O', 'treatment-O', 'with-O', 'psychopharmacologic-O', 'agents-O', '.-O']
['In-O', 'this-O', 'report-O', 'we-O', 'present-O', 'four-O', 'patients-O', 'treated-O', 'with-O', 'a-O', 'combination-O', 'of-O', 'different-O', 'psychotropic-O', 'drugs-O', ',-O', 'in-O', 'whom-O', 'asterixis-B-Disease', 'was-O', 'triggered-O', 'either-O', 'by-O', 'adding-O', 'carbamazepine-B-Chemical', '(-O', 'CBZ-B-Chemical', ')-O', 'to-O', 'a-O', 'treatment-O', 'regimen-O', ',-O', 'or-O', 'by-O', 'increasing-O', 'its-O', 'dosage-O', '.-O']
['Neither-O', 'dosage-O', 'nor-O', 'serum-O', 'levels-O', 'of-O', 'CBZ-B-Chemical', 'were-O', 'in-O', 'a-O', 'higher-O', 'range-O', '.-O']
['We-O', 'consider-O', 'asterixis-B-Disease', 'to-O', 'be-O', 'an-O', 'easily-O', 'overlooked-O', 'sign-O', 'of-O', 'neurotoxicity-B-Disease', ',-O', 'which-O', 'may-O', 'occur-O', 'even-O', 'at-O', 'low-O', 'or-O', 'moderate-O', 'dosage-O', 'levels-O', ',-O', 'if-O', 'certain-O', 'drugs-O', 'as-O', 'lithium-B-Chemical', 'or-O', 'clozapine-B-Chemical', 'are-O', 'used-O', 'in-O', 'combination-O', 'with-O', 'CBZ-B-Chemical']
['Pharmacodynamics-O', 'of-O', 'the-O', 'hypotensive-B-Disease', 'effect-O', 'of-O', 'levodopa-B-Chemical', 'in-O', 'parkinsonian-B-Disease', 'patients-O', '.-O']
['Blood-O', 'pressure-O', 'effects-O', 'of-O', 'i-O', '.-O']
['v-O', '.-O']
['levodopa-B-Chemical', 'were-O', 'examined-O', 'in-O', 'parkinsonian-B-Disease', 'patients-O', 'with-O', 'stable-O', 'and-O', 'fluctuating-O', 'responses-O', 'to-O', 'levodopa-B-Chemical', '.-O']
['The-O', 'magnitude-O', 'of-O', 'the-O', 'hypotensive-B-Disease', 'effect-O', 'of-O', 'levodopa-B-Chemical', 'was-O', 'concentration-O', 'dependent-O', 'and-O', 'was-O', 'fit-O', 'to-O', 'an-O', 'Emax-O', 'model-O', 'in-O', 'fluctuating-O', 'responders-O', '.-O']
['Stable-O', 'responders-O', 'demonstrated-O', 'a-O', 'small-O', 'hypotensive-B-Disease', 'response-O', '.-O']
['Baseline-O', 'blood-O', 'pressures-O', 'were-O', 'higher-O', 'in-O', 'fluctuating-O', 'patients-O', ';-O', 'a-O', 'higher-O', 'baseline-O', 'blood-O', 'pressure-O', 'correlated-O', 'with-O', 'greater-O', 'hypotensive-O', 'effects-O', '.-O']
['Antiparkinsonian-O', 'effects-O', 'of-O', 'levodopa-B-Chemical', 'temporally-O', 'correlated-O', 'with-O', 'blood-O', 'pressure-O', 'changes-O', '.-O']
['Phenylalanine-B-Chemical', ',-O', 'a-O', 'large-O', 'neutral-O', 'amino-O', 'acid-O', '(-O', 'LNAA-O', ')', 'competing-O', 'with-O', 'levodopa-B-Chemical', 'for-O', 'transport-O', 'across-O', 'the-O', 'blood-O', ',-O', 'brain-O', 'barrier-O', ',-O', 'reduced-O', 'the-O', 'hypotensive-B-Disease', 'and-O', 'antiparkinsonian-O', 'effects-O', 'of-O', 'levodopa-B-Chemical', '.-O']
['We-O', 'conclude-O', 'that-O', 'levodopa-B-Chemical', 'has-O', 'a-O', 'central-O', 'hypotensive-B-Disease', 'action-O', 'that-O', 'parallels-O', 'the-O', 'motor-O', 'effects-O', 'in-O', 'fluctuating-O', 'patients-O', '.-O']
['The-O', 'hypotensive-B-Disease']
['Syndrome-O', 'of-O', 'inappropriate-O', 'secretion-O', 'of-O', 'antidiuretic-O', 'hormone-O', 'after-O', 'infusional-O', 'vincristine-B-Chemical', '.-O']
['A-O', '77-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'with-O', 'refractory-O', 'multiple-B-Disease', 'myeloma-I-Disease', 'was-O', 'treated-O', 'with-O', 'a-O', '4-O', ',-O', 'day-O', 'continuous-O', 'intravenous-O', 'infusion-O', 'of-O', 'vincristine-B-Chemical', 'and-O', 'doxorubicin-B-Chemical', 'and-O', '4-O', 'days-O', 'of-O', 'oral-O', 'dexamethasone-B-Chemical', '.-O']
['Nine-O', 'days-O', 'after-O', 'her-O', 'second-O', 'cycle-O', 'she-O', 'presented-O', 'with-O', 'lethargy-B-Disease', 'and-O', 'weakness-B-Disease', 'associated-O', 'with-O', 'hyponatremia-B-Disease', '.-O']
['Evaluation-O', 'revealed-O', 'the-O', 'syndrome-O', 'of-O', 'inappropriate-O', 'secretion-O', 'of-O', 'antidiuretic-O', 'hormone-O', ',-O', 'which-O', 'was-O', 'attributed-O', 'to-O', 'the-O', 'vincristine-B-Chemical', 'infusion-O', '.-O']
['After-O', 'normal-O', 'serum-O', 'sodium-B-Chemical', 'levels-O', 'returned-O', ',-O', 'further-O', 'doxorubicin-B-Chemical', 'and-O', 'dexamethasone-B-Chemical', 'chemotherapy-O', 'without-O', 'vincristine-B-Chemical']
['Heart-B-Disease', 'failure-I-Disease', ':', 'to-O', 'digitalise-O', 'or-O', 'not-O', '?', 'The-O', 'view-O', 'against-O', '.-O']
['Despite-O', 'extensive-O', 'clinical-O', 'experience-O', 'the-O', 'role-O', 'of-O', 'digoxin-B-Chemical', 'is-O', 'still-O', 'not-O', 'well-O', 'defined-O', '.-O']
['In-O', 'patients-O', 'with-O', 'atrial-B-Disease', 'fibrillation-I-Disease', 'digoxin-B-Chemical', 'is-O', 'beneficial-O', 'for-O', 'ventricular-O', 'rate-O', 'control-O', '.-O']
['For-O', 'patients-O', 'in-O', 'sinus-B-Disease', 'rhythm-O', 'and-O', 'heart-B-Disease', 'failure-I-Disease', 'the-O', 'situation-O', 'is-O', 'less-O', 'clear-O', '.-O']
['Digoxin-B-Chemical', 'has-O', 'a-O', 'narrow-O', 'therapeutic-O', ':-O', 'toxic-O', 'ratio-O', 'and-O', 'concentrations-O', 'are-O', 'affected-O', 'by-O', 'a-O', 'number-O', 'of-O', 'drugs-O', '.-O']
['Also-O', ',-O', 'digoxin-B-Chemical', 'has-O', 'undesirable-O', 'effects-O', 'such-O', 'as-O', 'increasing-O', 'peripheral-O', 'resistance-O', 'and-O', 'myocardial-O', 'demands-O', ',-O', 'and-O', 'causing-O', 'arrhythmias-B-Disease', '.-O']
['There-O', 'is-O', 'a-O', 'paucity-O', 'of-O', 'data-O', 'from-O', 'well-O', ',-O', 'designed-O', 'trials-O', '.-O']
['The-O', 'trials-O', 'that-O', 'are-O', 'available-O', 'are-O', 'generally-O', 'small-O', 'with-O', 'limitations-O', 'in-O', 'design-O', 'and-O', 'these-O', 'show-O', 'variation-O', 'in-O', 'patient-O', 'benefit-O', '.-O']
['More-O', 'convincing-O', 'evidence-O', 'is-O', 'required-O', 'showing-O', 'that-O', 'digoxin-B-Chemical', 'improves-O', 'symptoms-O', 'or-O', 'exercise-O', 'capacity-O', '.-O']
['Furthermore-O', ',-O', 'no-O', 'trial-O', 'has-O', 'had-O', 'sufficient-O', 'power-O', 'to-O', 'evaluate-O', 'mortality-O', '.-O']
['Pooled-O', 'analysis-O', 'of-O', 'the-O', 'effects-O', 'of-O', 'other-O', 'inotropic-O', 'drugs-O', 'shows-O', 'an-O', 'excess-O', 'mortality-O', 'and-O', 'there-O', 'is-O', 'a-O', 'possibility-O', 'that-O', 'digoxin-B-Chemical', 'may-O', 'increase-O', 'mortality-O', 'after-O', 'myocardial-B-Disease', 'infarction-O', '(-O', 'MI-O', ')-O', '.', 'Angiotensin-B-Chemical', ',-O', 'converting-O', 'enzyme-O', '(-O', 'ACE-O', ')-O', 'inhibitors-O', 'should-O', 'be-O', 'used-O', 'first-O', 'as-O', 'they-O', 'are-O', 'safer-O', ',-O', 'do-O', 'not-O', 'require-O', 'blood-O', 'level-O', 'monitoring-O', ',-O', 'modify-O', 'progression-O', 'of-O', 'disease-O', ',-O', 'relieve-O', 'symptoms-O', ',-O', 'improve-O', 'exercise-O', 'tolerance-O', 'and-O', 'reduce-O', 'mortality-O', '.-O']
['Caution-O', 'should-O', 'be-O', 'exercised-O', 'in-O', 'using-O', 'digoxin-B-Chemical', 'until-O', 'large-O', 'mortality-O', 'trials-O', 'are-O', 'completed-O', 'showing-O', 'either-O', 'benefit-O', 'or-O', 'harm-O', '.-O']
['Until-O', 'then-O', 'digoxin-B-Chemical']
['Intravascular-B-Disease', 'hemolysis-I-Disease', 'and-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'following-O', 'intermittent-O', 'rifampin-B-Chemical', 'therapy-O', '.-O']
['Renal-B-Disease', 'failure-I-Disease', 'is-O', 'a-O', 'rare-O', 'complication-O', 'associated-O', 'with-O', 'the-O', 'use-O', 'of-O', 'rifampin-B-Chemical', '.-O']
['Intravascular-O', 'hemolysis-B-Disease', 'leading-O', 'to-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'following-O', 'rifampin-B-Chemical', 'therapy-O', 'is-O', 'extremely-O', 'rare-O', '.-O']
['Two-O', 'patients-O', 'with-O', 'leprosy-B-Disease', 'who-O', 'developed-O', 'hemolysis-B-Disease', 'and-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'following-O', 'rifampin-B-Chemical']
['Zidovudine-B-Chemical', ',-O', 'induced-O', 'hepatitis-B-Disease', '.-O']
['A-O', 'case-O', 'of-O', 'acute-B-Disease', 'hepatitis-I-Disease', 'induced-O', 'by-O', 'zidovudine-B-Chemical', 'in-O', 'a-O', '38-O', ',-O', 'year-O', ',-O', 'old-O', 'patient-O', 'with-O', 'AIDS-B-Disease', 'is-O', 'presented-O', '.-O']
['The-O', 'mechanism-O', 'whereby-O', 'the-O', 'hepatitis-B-Disease', 'was-O', 'induced-O', 'is-O', 'not-O', 'known-O', '.-O']
['However-O', ',-O', 'the-O', 'patient-O', 'tolerated-O', 'well-O', 'an-O', 'alternative-O', 'reverse-O', 'transcriptase-O', 'inhibitor-O', ',-O', '2-O', '3-O', ''-O', 'dideoxyinosine-B-Chemical', '.-O']
['Physicians-O', 'caring-O', 'for-O', 'patients-O', 'with-O', 'AIDS-B-Disease']
['Thoracic-O', 'hematomyelia-B-Disease', 'secondary-O', 'to-O', 'coumadin-B-Chemical', 'anticoagulant-O', 'therapy-O', ':-O', 'a-O', 'case-O', 'report-O', '.-O']
['A-O', 'case-O', 'of-O', 'thoracic-B-Disease', 'hematomyelia-I-Disease']
['Mania-B-Disease', 'associated-O', 'with-O', 'fluoxetine-B-Chemical', 'treatment-O', 'in-O', 'adolescents-O', '.-O']
['Fluoxetine-B-Chemical', ',-O', 'a-O', 'selective-O', 'serotonin-B-Chemical', 'reuptake-O', 'inhibitor-O', ',-O', 'is-O', 'gaining-O', 'increased-O', 'acceptance-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'adolescent-O', 'depression-B-Disease', '.-O']
['Generally-O', 'safe-O', 'and-O', 'well-O', 'tolerated-O', 'by-O', 'adults-O', ',-O', 'fluoxetine-B-Chemical', 'has-O', 'been-O', 'reported-O', 'to-O', 'induce-O', 'mania-B-Disease', '.-O']
['The-O', 'cases-O', 'of-O', 'five-O', 'depressed-B-Disease', 'adolescents-O', ',-O', '14-O', ',-O', '16-O', 'years-O', 'of-O', 'age-O', ',-O', 'who-O', 'developed-O', 'mania-B-Disease', 'during-O', 'pharmacotherapy-O', 'with-O', 'fluoxetine-B-Chemical', ',-O', 'are-O', 'reported-O', 'here-O', '.-O']
['Apparent-O', 'risk-O', 'factors-O', 'for-O', 'the-O', 'development-O', 'of-O', 'mania-B-Disease', 'or-O', 'hypomania-B-Disease', 'during-O', 'fluoxetine-B-Chemical', 'pharmacotherapy-O', 'in-O', 'this-O', 'population-O', 'were-O', 'the-O', 'combination-O', 'of-O', 'attention-deficit-B-Disease', 'hyperactivity-B-Disease', 'disorder-I-Disease', 'and-O', 'affective-O', 'instability-O', ';-O', 'major-O', 'depression-B-Disease', 'with-O', 'psychotic-B-Disease', 'features-O', ';-O', 'a-O', 'family-O', 'history-O', 'of-O', 'affective-O', 'disorder-O', ',-O', 'especially-O', 'bipolar-B-Disease', 'disorder-I-Disease', ';-O', 'and-O', 'a-O', 'diagnosis-O', 'of-O', 'bipolar-B-Disease', 'disorder-I-Disease', '.-O']
['Further-O', 'study-O', 'is-O', 'needed-O', 'to-O', 'determine-O', 'the-O', 'optimal-O', 'dosage-O', 'and-O', 'to-O', 'identify-O', 'risk-O', 'factors-O', 'that-O', 'increase-O', 'individual-O', 'vulnerability-O', 'to-O', 'fluoxetine-B-Chemical', 'induced-O', 'mania-B-Disease']
['Gemfibrozil-B-Chemical', ',-O', 'lovastatin-B-Chemical', 'therapy-O', 'for-O', 'primary-O', 'hyperlipoproteinemias-B-Disease', '.-O']
['The-O', 'specific-O', 'aim-O', 'of-O', 'this-O', 'retrospective-O', ',-O', 'observational-O', 'study-O', 'was-O', 'to-O', 'assess-O', 'safety-O', 'and-O', 'efficacy-O', 'of-O', 'long-O', ',-O', 'term-O', '(-O', '21-O', 'months-O', '/-O', 'patient-O', ')-O', 'open-O', ',-O', 'label-O', ',-O', 'gemfibrozil-B-Chemical', ',-O', 'lovastatin-B-Chemical', 'treatment-O', 'in-O', '80-O', 'patients-O', 'with-O', 'primary-O', 'mixed-O', 'hyperlipidemia-B-Disease', '(-O', '68-O', '%-O', 'of-O', 'whom-O', 'had-O', 'atherosclerotic-B-Disease', 'vascular-O', 'disease-O', ').-O', 'Because-O', 'ideal-O', 'lipid-O', 'targets-O', 'were-O', 'not-O', 'reached-O', '(-O', 'low-O', ',-O', 'density-O', 'lipoprotein-O', '(-O', 'LDL-O', ')-O', 'cholesterol-B-Chemical', 'less-O', 'than-O', '130-O', 'mg-O', '/-O', 'dl-O', ',-O', 'high-O', ',-O', 'density-O', 'lipoprotein-O', '(-O', 'HDL-O', ')-O', 'cholesterol-B-Chemical', 'greater-O', 'than-O', '35-O', 'mg-O', '/-O', 'dl-O', ',-O', 'or-O', 'total-O', 'cholesterol-O', '/-O', 'HDL-O', 'cholesterol-O', 'less-O', 'than-O', '4-O', '.-O']
['5-O', 'mg-O', '/-O', 'dl-O', ')-O', 'with-O', 'diet-O', 'plus-O', 'a-O', 'single-O', 'drug-O', ',-O', 'gemfibrozil-B-Chemical', '(-O', '1-O', '.-O']
['2-O', 'g-O', '/-O', 'day-O', ')-O', 'lovastatin-B-Chemical', '(--O', 'primarily-O', '20-O', 'or-O', '40-O', 'mg-O', ')-O', 'treatment-O', 'was-O', 'given-O', '.-O']
['Follow-O', ',-O', 'up-O', 'visits-O', 'were-O', 'scheduled-O', 'with-O', '2-O', ',-O', 'drug-O', 'therapy-O', 'every-O', '6-O', 'to-O', '8-O', 'weeks-O', ',-O', 'an-O', 'average-O', 'of-O', '10-O', '.-O']
['3-O', 'visits-O', 'per-O', 'patient-O', ',-O', 'with-O', '741-O', 'batteries-O', 'of-O', '6-O', 'liver-O', 'function-O', 'tests-O', 'and-O', '714-O', 'creatine-B-Chemical', 'phosphokinase-O', 'levels-O', 'measured-O', '.-O']
['Only-O', '1-O', 'of-O', 'the-O', '4-O', ',-O', '446-O', 'liver-O', 'function-O', 'tests-O', '(-O', '0-O', '.-O']
['02-O', ')-O', 'a-O', 'gamma-O', 'glutamyl-O', 'transferase-O', ',-O', 'was-O', 'greater-O', 'than-O', 'or-O', 'equal-O', 'to-O', '3-O', 'times-O', 'the-O', 'upper-O', 'normal-O', 'limit-O', '.-O']
['Of-O', 'the-O', '714-O', 'creatine-B-Chemical', 'phosphokinase-O', 'levels-O', ',-O', '9-O', '%-O', 'were-O', 'high-O', ';-O', 'only-O', '1-O', '(-O', '0-O', '.-O']
['1-O', ')-O', 'was-O', 'greater-O', 'than-O', 'or-O', 'equal-O', 'to-O', '3-O', 'times-O', 'the-O', 'upper-O', 'normal-O', 'limit-O', '.-O']
['With-O', '2-O', ',-O', 'drug-O', 'therapy-O', ',-O', 'mean-O', 'total-O', 'cholesterol-B-Chemical', 'decreased-O', '22-O', '%-O', 'from-O', '255-O', 'to-O', '200-O', 'mg-O', '/-O', 'dl-O', ',-O', 'triglyceride-O', 'levels-O', 'decreased-O', '35-O', '%-O', 'from-O', '236-O', 'to-O', '154-O', 'mg-O', '/-O', 'dl-O', ',-O', 'LDL-O', 'cholesterol-B-Chemical', 'decreased-O', '26-O', '%-O', 'from-O', '176-O', 'to-O', '131-O', 'mg-O', '/-O', 'dl-O', ',-O', 'and-O', 'the-O', 'total-O', 'cholesterol-B-Chemical', '/-O', 'HDL-O', 'cholesterol-B-Chemical', 'ratio-O', 'decreased-O', '24-O', '%-O', 'from-O', '7-O', '.-O']
['1-O', 'to-O', '5-O', '.-O']
['4-O', ',-O', 'all-O', 'p-O', 'less-O', 'than-O', 'or-O', 'equal-O', 'to-O', '0-O', '.-O']
['0001-O', '.-O']
['Myositis-B-Disease', ',-O', 'attributable-O', 'to-O', 'the-O', 'drug-O', 'combination-O', 'and-O', 'symptomatic-O', 'enough-O', 'to-O', 'discontinue-O', 'it-O', ',-O', 'occurred-O', 'in-O', '3-O', '%-O', 'of-O', 'patients-O', ',-O', 'and-O', 'in-O', '1-O', '%-O', 'with-O', 'concurrent-O', 'high-O', 'creatine-B-Chemical', 'phosphokinase-O', '(-O', '769-O', 'U-O', '/-O', 'liter-O', ');-O', 'no-O', 'patients-O', 'had-O', 'rhabdomyolysis-B-Disease', 'or-O', 'myoglobinuria-B-Disease']
['Hepatocellular-B-Disease', 'carcinoma-I-Disease', 'in-O', 'Fanconi-O', 'anemia-B-Disease', 'treated-O', 'with-O', 'androgen-O', 'and-O', 'corticosteroid-B-Chemical', '.-O']
['The-O', 'case-O', 'of-O', 'an-O', '11-O', ',-O', 'year-O', ',-O', 'old-O', 'boy-O', 'is-O', 'reported-O', 'who-O', 'was-O', 'known-O', 'to-O', 'have-O', 'Fanconi-B-Disease', 'anemia-I-Disease', 'for-O', '3-O', 'years-O', 'and-O', 'was-O', 'treated-O', 'with-O', 'androgens-B-Chemical', ',-O', 'corticosteroids-B-Chemical', 'and-O', 'transfusions-O', '.-O']
['Two-O', 'weeks-O', 'before-O', 'his-O', 'death-O', 'he-O', 'was-O', 'readmitted-O', 'because-O', 'of-O', 'aplastic-B-Disease', 'crisis-O', 'with-O', 'septicemia-B-Disease', 'and-O', 'marked-O', 'abnormalities-O', 'in-O', 'liver-O', 'function-O', 'and-O', 'died-O', 'of-O', 'hemorrhagic-B-Disease', 'bronchopneumonia-I-Disease', '.-O']
['At-O', 'autopsy-O', 'peliosis-B-Disease', 'and-O', 'multiple-O', 'hepatic-O', 'tumors-O', 'were-O', 'found-O', 'which-O', 'histologically-O', 'proved-O', 'to-O', 'be-O', 'well-O', ',-O', 'differentiated-O', 'hepatocellular-B-Disease', 'carcinoma-I-Disease', '.-O']
['This-O', 'case-O', 'contributes-O', 'to-O', 'the-O', 'previous-O', 'observations-O', 'that-O', 'non-O', ',-O', 'metastasizing-O', 'hepatic-B-Disease', 'neoplasms-I-Disease', 'and-O', 'peliosis-B-Disease', 'can-O', 'develop-O', 'in-O', 'patients-O', 'with-O', 'androgen-O', ',-O', 'and-O', 'corticosteroid-B-Chemical', ',-O', 'treated-O', 'Fanconi-B-Disease', 'anemia-I-Disease']
['Chronic-O', 'lesion-O', 'of-O', 'rostral-O', 'ventrolateral-O', 'medulla-O', 'in-O', 'spontaneously-O', 'hypertensive-B-Disease', 'rats-O', '.-O']
['We-O', 'studied-O', 'the-O', 'effects-O', 'of-O', 'chronic-O', 'selective-O', 'neuronal-O', 'lesion-O', 'of-O', 'rostral-O', 'ventrolateral-O', 'medulla-O', 'on-O', 'mean-O', 'arterial-O', 'pressure-O', ',-O', 'heart-O', 'rate-O', ',-O', 'and-O', 'neurogenic-O', 'tone-O', 'in-O', 'conscious-O', ',-O', 'unrestrained-O', 'spontaneously-O', 'hypertensive-B-Disease', 'rats-O', '.-O']
['The-O', 'lesions-O', 'were-O', 'placed-O', 'via-O', 'bilateral-O', 'microinjections-O', 'of-O', '30-O', 'nmol-O', '/-O', '200-O', 'nl-O', 'N-methyl-D-aspartic-B-Chemical', 'acid-I-Chemical', '.-O']
['The-O', 'restimulation-O', 'of-O', 'this-O', 'area-O', 'with-O', 'N-methyl-D-aspartic-B-Chemical', 'acid-I-Chemical', '15-O', 'days-O', 'postlesion-O', 'failed-O', 'to-O', 'produce-O', 'a-O', 'pressor-O', 'response-O', '.-O']
['One-O', 'day-O', 'postlesion-O', ',-O', 'the-O', 'resting-O', 'mean-O', 'arterial-O', 'pressure-O', 'was-O', 'significantly-O', 'decreased-O', 'in-O', 'lesioned-O', 'rats-O', 'when-O', 'compared-O', 'with-O', 'sham-O', 'rats-O', '(-O', '100-O', '+-O', '7-O', 'versus-O', '173-O', '+-O', '4-O', 'mm-O', 'Hg-O', ',-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'Fifteen-O', 'days-O', 'later-O', ',-O', 'the-O', 'lesioned-O', 'group-O', 'still-O', 'showed-O', 'values-O', 'significantly-O', 'lower-O', 'than-O', 'the-O', 'sham-O', 'group-O', '(-O', '150-O', '+-O', '6-O', 'versus-O', '167-O', '+-O', '5-O', 'mm-O', 'Hg-O', ',-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'No-O', 'significant-O', 'heart-O', 'rate-O', 'differences-O', 'were-O', 'observed-O', 'between-O', 'the-O', 'sham-O', 'and-O', 'lesioned-O', 'groups-O', '.-O']
['The-O', 'ganglionic-O', 'blocker-O', 'trimethaphan-B-Chemical', '(-O', '5-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['v-O', ')-O', 'caused-O', 'similar-O', 'reductions-O', 'in-O', 'mean-O', 'arterial-O', 'pressure-O', 'in-O', 'both-O', 'lesioned-O', 'and-O', 'sham-O', 'groups-O', '.-O']
['The-O', 'trimethaphan-B-Chemical', ',-O', 'induced-O', 'hypotension-B-Disease', 'was-O', 'accompanied-O', 'by-O', 'a-O', 'significant-O', 'bradycardia-B-Disease', 'in-O', 'lesioned-O', 'rats-O', '(-O', '32-O', '+-O', '13-O', 'beats-O', 'per-O', 'minute-O', ')-O', 'but-O', 'a-O', 'tachycardia-B-Disease', 'in-O', 'sham-O', 'rats-O', '(+-O', '33-O', '+-O', '12-O', 'beats-O', 'per-O', 'minute-O', ')-O', '1-O', 'day-O', 'postlesion-O', '.-O']
['Therefore-O', ',-O', 'rostral-O', 'ventrolateral-O', 'medulla-O', 'neurons-O', 'appear-O', 'to-O', 'play-O', 'a-O', 'significant-O', 'role-O', 'in-O', 'maintaining-O', 'hypertension-B-Disease', 'in-O', 'conscious-O', 'spontaneously-O', 'hypertensive-B-Disease', 'rats-O', '.-O']
['Spinal-O', 'or-O', 'suprabulbar-O', 'structures-O', 'could-O', 'be-O', 'responsible-O', 'for-O', 'the-O', 'gradual-O', 'recovery-O', 'of-O', 'the-O', 'hypertension-B-Disease']
['Damage-O', 'of-O', 'substantia-O', 'nigra-O', 'pars-O', 'reticulata-O', 'during-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'status-B-Disease', 'epilepticus-I-Disease', 'in-O', 'the-O', 'rat-O', ':-O', 'immunohistochemical-O', 'study-O', 'of-O', 'neurons-O', ',-O', 'astrocytes-O', 'and-O', 'serum-O', ',-O', 'protein-O', 'extravasation-O', '.-O']
['The-O', 'substantia-O', 'nigra-O', 'has-O', 'a-O', 'gating-O', 'function-O', 'controlling-O', 'the-O', 'spread-O', 'of-O', 'epileptic-B-Disease', 'seizure-B-Disease', 'activity-O', '.-O']
['Additionally-O', ',-O', 'in-O', 'models-O', 'of-O', 'prolonged-O', 'status-B-Disease', 'epilepticus-I-Disease', 'the-O', 'pars-O', 'reticulata-O', 'of-O', 'substantia-O', 'nigra-O', '(-O', 'SNR-O', ')-O', 'suffers-O', 'from-O', 'a-O', 'massive-O', 'lesion-O', 'which-O', 'may-O', 'arise-O', 'from-O', 'a-O', 'massive-O', 'metabolic-O', 'derangement-O', 'and-O', 'hyperexcitation-O', 'developing-O', 'in-O', 'the-O', 'activated-O', 'SNR-O', '.-O']
['In-O', 'this-O', 'study-O', ',-O', 'status-B-Disease', 'epilepticus-I-Disease', 'was-O', 'induced-O', 'by-O', 'systemic-O', 'injection-O', 'of-O', 'pilocarpine-B-Chemical', 'in-O', 'rats-O', '.-O']
['The-O', 'neuropathology-O', 'of-O', 'SNR-O', 'was-O', 'investigated-O', 'using-O', 'immunohistochemical-O', 'techniques-O', 'with-O', 'the-O', 'major-O', 'emphasis-O', 'on-O', 'the-O', 'time-O', ',-O', 'course-O', 'of-O', 'changes-O', 'in-O', 'neurons-O', 'and-O', 'astrocytes-O', '.-O']
['Animals-O', 'surviving-O', '20-O', ',-O', '30-O', ',-O', '40-O', ',-O', '60-O', 'min-O', ',-O', '2-O', ',-O', '3-O', ',-O', '6-O', 'hours-O', ',-O', '1-O', ',-O', '2-O', ',-O', 'and-O', '3-O', 'days-O', 'after-O', 'induction-O', 'of-O', 'status-B-Disease', 'epilepticus-I-Disease', 'were-O', 'perfusion-O', ',-O', 'fixed-O', ',-O', 'and-O', 'brains-O', 'processed-O', 'for-O', 'immunohistochemical-O', 'staining-O', 'of-O', 'SNR-O', '.-O']
['Nissl-O', ',-O', 'staining-O', 'and-O', 'antibodies-O', 'against-O', 'the-O', 'neuron-O', ',-O', 'specific-O', 'calcium-B-Chemical', ',-O', 'binding-O', 'protein-O', ',-O', 'parvalbumin-B-Chemical', ',-O', 'served-O', 'to-O', 'detect-O', 'neuronal-B-Disease', 'damage-I-Disease', 'in-O', 'SNR-O', '.-O']
['Antibodies-O', 'against-O', 'the-O', 'astroglia-O', ',-O', 'specific-O', 'cytoskeletal-O', 'protein-O', ',-O', 'glial-O', 'fibrillary-O', 'acidic-O', 'protein-O', '(-O', 'GFAP-O', ')-O', 'and-O', 'against-O', 'the-O', 'glial-O', 'calcium-O', 'binding-O', 'protein-O', ',-O', 'S-O', '100-O', 'protein-O', ',-O', 'were-O', 'used-O', 'to-O', 'assess-O', 'the-O', 'status-O', 'of-O', 'astrocytes-O', '.-O']
['Immunohistochemical-O', 'staining-O', 'for-O', 'serum-O', ',-O', 'albumin-B-Chemical', 'and-O', 'immunoglobulins-B-Chemical', 'in-O', 'brain-O', 'tissue-O', 'was-O', 'taken-O', 'as-O', 'indicator-O', 'of-O', 'blood-O', ',-O', 'brain-O', 'barrier-O', 'disturbances-O', 'and-O', 'vasogenic-O', 'edema-O', 'formation-O', '.-O']
['Immunohistochemical-O', 'staining-O', 'indicated-O', 'loss-O', 'of-O', 'GFAP-B-Chemical', ',-O', 'staining-O', 'already-O', 'at-O', '30-O', 'min-O', 'after-O', 'induction-O', 'of-O', 'seizures-B-Disease', 'in-O', 'an-O', 'oval-O', 'focus-O', 'situated-O', 'in-O', 'the-O', 'center-O', 'of-O', 'SNR-O', 'while-O', 'sparing-O', 'medial-O', 'and-O', 'lateral-O', 'aspects-O', '.-O']
['At-O', '1-O', 'h-O', 'there-O', 'was-O', 'additional-O', 'vacuolation-O', 'in-O', 'S-O', ',-O', '100-O', 'protein-O', 'staining-O', '.-O']
['By-O', '2-O', 'hours-O', ',-O', 'parvalbumin-B-Chemical', ',-O', 'staining-O', 'changed-O', 'in-O', 'the-O', 'central-O', 'SNR-O', 'indicating-O', 'neuronal-B-Disease', 'damage-I-Disease', ',-O', 'and-O', 'Nissl-O', ',-O', 'staining-O', 'visualized-O', 'some-O', 'neuronal-B-Disease', 'distortion-O', '.-O']
['Staining-O', 'for-O', 'serum-O', ',-O', 'proteins-O', 'occurred-O', 'in-O', 'a-O', 'patchy-O', 'manner-O', 'throughout-O', 'the-O', 'forebrain-O', 'during-O', 'the-O', 'first-O', 'hours-O', '.-O']
['By-O', '6-O', 'h-O', ',-O', 'vasogenic-O', 'edema-B-Disease', 'covered-O', 'the-O', 'lesioned-O', 'SNR-O', '.-O']
['By-O', '24-O', 'h-O', ',-O', 'glial-O', 'and-O', 'neuronal-O', 'markers-O', 'indicated-O', 'a-O', 'massive-O', 'lesion-B-Disease', 'in-O', 'the-O', 'center-O', 'of-O', 'SNR-O', '.-O']
['By-O', '48-O', ',-O', '72-O', 'h-O', ',-O', 'astrocytes-O', 'surrounding-O', 'the-O', 'lesion-O', 'increased-O', 'in-O', 'size-O', ',-O', 'and-O', 'polymorphic-O', 'phagocytotic-O', 'cells-O', 'invaded-O', 'the-O', 'damaged-O', 'area-O', '.-O']
['In-O', 'a-O', 'further-O', 'group-O', 'of-O', 'animals-O', 'surviving-O', '1-O', 'to-O', '5-O', 'days-O', ',-O', 'conventional-O', 'paraffin-O', ',-O', 'sections-O', 'confirmed-O', 'the-O', 'neuronal-O', 'and-O', 'glial-O', 'damage-O', 'of-O', 'SNR-O', '.-O']
['Additional-O', 'pathology-O', 'of-O', 'similar-O', 'quality-O', 'was-O', 'found-O', 'in-O', 'the-O', 'globus-O', 'pallidus-O', '.-O']
['Since-O', 'astrocytes-O', 'were-O', 'always-O', 'damaged-O', 'in-O', 'parallel-O', 'with-O', 'neurons-O', 'in-O', 'SNR-O', 'it-O', 'is-O', 'proposed-O', 'that-O', 'the-O', 'anatomical-O', 'and-O', 'functional-O', 'interrelationship-O', 'between-O', 'neurons-O', 'and-O', 'astrocytes-O', 'is-O', 'particularly-O', 'tight-O', 'in-O', 'SNR-O', '.-O']
['Both-O', 'cell-O', 'elements-O', 'may-O', 'suffer-O', 'in-O', 'common-O', 'from-O', 'metabolic-O', 'disturbance-O', 'and-O', 'neurotransmitter-O', 'dysfunction-O', 'as-O', 'occur-O', 'during-O', 'massive-O', 'status-B-Disease', 'epilepticus-I-Disease']
['Reduced-O', 'cardiotoxicity-B-Disease', 'of-O', 'doxorubicin-B-Chemical', 'given-O', 'in-O', 'the-O', 'form-O', 'of-O', 'N-(2-hydroxypropyl)methacrylamide-B-Chemical', 'conjugates-O', ':-O', 'and-O', 'experimental-O', 'study-O', 'in-O', 'the-O', 'rat-O', '.-O']
['A-O', 'rat-O', 'model-O', 'was-O', 'used-O', 'to-O', 'evaluate-O', 'the-O', 'general-O', 'acute-O', 'toxicity-O', 'and-O', 'the-O', 'late-O', 'cardiotoxicity-B-Disease', 'of-O', '4-O', 'mg-O', '/-O', 'kg-O', 'doxorubicin-B-Chemical', '(-O', 'DOX-B-Chemical', ')-O', 'given-O', 'either-O', 'as-O', 'free-O', 'drug-O', 'or-O', 'in-O', 'the-O', 'form-O', 'of-O', 'three-O', 'N-(2-hydroxypropyl)methacrylamide-B-Chemical', '(-O', 'HPMA-B-Chemical', ')-O', 'copolymer-O', 'conjugates-O', '.-O']
['In-O', 'these-O', 'HPMA-O', 'copolymers-O', ',-O', 'DOX-B-Chemical', 'was-O', 'covalently-O', 'bound-O', 'via-O', 'peptide-O', 'linkages-O', 'that-O', 'were-O', 'either-O', 'non-O', ',-O', 'biodegradable-O', '(-O', 'Gly-O', ',-O', 'Gly-O', ')-O', 'or-O', 'degradable-O', 'by-O', 'lysosomal-O', 'proteinases-O', '(-O', 'Gly-Phe-Leu-Gly-O', ')-O', '.-O', 'In-O', 'addition-O', ',-O', 'one-O', 'biodegradable-O', 'conjugate-O', 'containing-O', 'galactosamine-B-Chemical', 'was-O', 'used-O', ';-O', 'this-O', 'residue-O', 'was-O', 'targeted-O', 'to-O', 'the-O', 'liver-O', '.-O']
['Over-O', 'the-O', 'first-O', '3-O', 'weeks-O', 'after-O', 'the-O', 'i-O', '.-O']
['v-O', '.-O']
['administration-O', 'of-O', 'free-O', 'and-O', 'polymer-O', ',-O', 'bound-O', 'DOX-B-Chemical', ',-O', 'all-O', 'animals-O', 'showed-O', 'a-O', 'transient-O', 'reduction-O', 'in-O', 'body-O', 'weight-O', '.-O']
['However-O', ',', 'the-O', 'maximal-O', 'reduction-O', 'in-O', 'body-O', 'weight-O', 'seen-O', 'in-O', 'animals-O', 'that-O', 'received-O', 'polymer-O', ',', 'bound-O', 'DOX-B-Chemical', '(-O', '4-O', 'mg-O', '/-O', 'kg-O', ')-O', 'was-O', 'significantly-O', 'lower-O', 'than-O', 'that-O', 'observed-O', 'in-O', 'those-O', 'that-O', 'received-O', 'free-O', 'DOX-B-Chemical', '(-O', '4-O', 'mg-O', '/-O', 'kg-O', ')-O', 'or-O', 'a-O', 'mixture-O', 'of-O', 'the-O', 'unmodified-O', 'parent-O', 'HPMA-O', 'copolymer-O', 'and-O', 'free-O', 'DOX-B-Chemical', '(-O', '4-O', 'mg-O', '/-O', 'kg-O', ';-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ').-O', 'Throughout-O', 'the-O', 'study-O', '(-O', '20-O', 'weeks-O', '),', 'deaths-O', 'related-O', 'to-O', 'cardiotoxicity-B-Disease', 'were-O', 'observed-O', 'only-O', 'in-O', 'animals-O', 'that-O', 'received-O', 'either-O', 'free-O', 'DOX-B-Chemical', 'or-O', 'the-O', 'mixture-O', 'of-O', 'HPMA-O', 'copolymer-O', 'and-O', 'free-O', 'DOX-B-Chemical', ';-O', 'in-O', 'these-O', 'cases-O', ',-O', 'histological-O', 'investigations-O', 'revealed-O', 'marked-O', 'changes-O', 'in-O', 'the-O', 'heart-O', 'that-O', 'were-O', 'consistent-O', 'with-O', 'DOX-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', '.-O']
['Sequential-O', 'measurements-O', 'of-O', 'cardiac-O', 'output-O', 'in-O', 'surviving-O', 'animals-O', 'that-O', 'received-O', 'either-O', 'free-O', 'DOX-B-Chemical', 'or-O', 'the-O', 'mixture-O', 'of-O', 'HPMA-O', 'copolymer-O', 'and-O', 'free-O', 'DOX-B-Chemical', 'showed-O', 'a-O', 'reduction-O', 'of-O', 'approximately-O', '30-O', '%-O', 'in-O', 'function-O', 'beginning-O', 'at-O', 'the-O', '4th-O', 'week-O', 'after-O', 'drug-O', 'administration-O', '.-O']
['The-O', 'heart-O', 'rate-O', 'in-O', 'these-O', 'animals-O', 'was-O', 'approximately-O', '12-O', '%-O', 'lower-O', 'than-O', 'that-O', 'measured-O', 'in-O', 'age-O', ',-O', 'matched-O', 'control-O', 'rats-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'Animals-O', 'that-O', 'were-O', 'given-O', 'the-O', 'HPMA-B-Chemical', 'copolymer-O', 'conjugates-O', 'containing-O', 'DOX-B-Chemical', 'exhibited-O', 'no-O', 'significant-O', 'change-O', 'in-O', 'cardiac-O', 'output-O', 'throughout-O', 'the-O', 'study-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ')-O', 'In-O', 'addition-O', ',-O', 'no-O', 'significant-O', 'histological-O', 'change-O', 'was-O', 'observed-O', 'in-O', 'the-O', 'heart-O', 'of-O', 'animals-O', 'that-O', 'received-O', 'DOX-B-Chemical', 'in-O', 'the-O', 'form-O', 'of-O', 'HPMA-O']
['Topical-O', '0-O', '.-O']
['025-O', '%-O', 'capsaicin-B-Chemical', 'in-O', 'chronic-O', 'post-herpetic-O', 'neuralgia-B-Disease', ':-O', 'efficacy-O', ',-O', 'predictors-O', 'of-O', 'response-O', 'and-O', 'long-O', ',-O', 'term-O', 'course-O', '.-O']
['In-O', 'order-O', 'to-O', 'evaluate-O', 'the-O', 'efficacy-O', ',-O', 'time-O', ',-O', 'course-O', 'of-O', 'action-O', 'and-O', 'predictors-O', 'of-O', 'response-O', 'to-O', 'topical-O', 'capsaicin-B-Chemical', ',-O', '39-O', 'patients-O', 'with-O', 'chronic-O', 'post-herpetic-O', 'neuralgia-B-Disease', '(-O', 'PHN-B-Disease', ')-O', ',', 'median-O', 'duration-O', '24-O', 'months-O', ',-O', 'were-O', 'treated-O', 'with-O', '0-O', '.-O']
['025-O', '%-O', 'capsaicin-B-Chemical', 'cream-O', 'for-O', '8-O', 'weeks-O', '.-O']
['During-O', 'therapy-O', 'the-O', 'patients-O', 'rated-O', 'their-O', 'pain-B-Disease', 'on-O', 'a-O', 'visual-O', 'analogue-O', 'scale-O', '(-O', 'VAS-O', ')-O', 'and-O', 'a-O', 'verbal-O', 'outcome-O', 'scale-O', '.-O']
['A-O', 'follow-O', ',-O', 'up-O', 'investigation-O', 'was-O', 'performed-O', '10-O', ',-O', '12-O', 'months-O', 'after-O', 'study-O', 'onset-O', 'on-O', 'the-O', 'patients-O', 'who-O', 'had-O', 'improved-O', '.-O']
['Nineteen-O', 'patients-O', '(-O', '48-O', '.-O']
['7-O', ')-O', 'substantially-O', 'improved-O', 'after-O', 'the-O', '8-O', ',-O', 'week-O', 'trial-O', ';-O', '5-O', '(-O', '12-O', '.-O']
['8-O', ')-O', 'discontinued-O', 'therapy-O', 'due-O', 'to-O', 'side-O', ',-O', 'effects-O', 'such-O', 'as-O', 'intolerable-O', 'capsaicin-B-Chemical', ',-O', 'induced-O', 'burning-O', 'sensations-O', '(-O', '4-O', ')-O', 'or-O', 'mastitis-B-Disease', '(-O', '1-O', ')-O', ';-O', '15-O', '(-O', '38-O', '.-O']
['5-O', ')-O', 'reported-O', 'no-O', 'benefit-O', '.-O']
['The-O', 'decrease-O', 'in-O', 'VAS-O', 'ratings-O', 'was-O', 'significant-O', 'after-O', '2-O', 'weeks-O', 'of-O', 'continuous-O', 'application-O', '.-O']
['Of-O', 'the-O', 'responders-O', '72-O', '.-O']
['2-O', '%-O', 'were-O', 'still-O', 'improved-O', 'at-O', 'the-O', 'follow-O', ',-O', 'up-O', ';-O', 'only-O', 'one-O', 'third-O', 'of-O', 'them-O', 'had-O', 'continued-O', 'application-O', 'irregularly-O', '.-O']
['Treatment-O', 'effect-O', 'was-O', 'not-O', 'dependent-O', 'on-O', 'patient-O', 'x-O', 's-O', 'age-O', ',-O', 'duration-O', 'or-O', 'localization-O', 'of-O', 'PHN-B-Disease', '(-O', 'trigeminal-B-Disease', 'involvement-O', 'was-O', 'excluded-O', ')-O', 'sensory-O', 'disturbance-O', 'or-O', 'pain-B-Disease', 'character-O', '.-O']
['Treatment-O', 'response-O', 'was-O', 'not-O', 'correlated-O', 'with-O', 'the-O', 'incidence-O', ',-O', 'time-O', ',-O', 'course-O', 'or-O', 'severity-O', 'of-O', 'capsaicin-B-Chemical', ',-O', 'induced-O', 'burning-B-Disease', '.-O']
['If-O', 'confirmed-O', 'in-O', 'controlled-O', 'trials-O', ',-O', 'the-O', 'long-O', ',-O', 'term-O', 'results-O', 'of-O', 'this-O', 'open-O', ',-O', 'non-O', ',-O', 'randomized-O', 'study-O', 'might-O', 'indicate-O', 'that-O', 'the-O', 'analgesic-O', 'effect-O', 'of-O', 'capsaicin-B-Chemical', 'in-O', 'PHN-B-Disease']
['Serotonin-B-Chemical', 'reuptake-O', 'inhibitors-O', ',-O', 'paranoia-B-Disease', ',-O', 'and-O', 'the-O', 'ventral-O', 'basal-O', 'ganglia-O', '.-O']
['Antidepressants-B-Chemical', 'have-O', 'previously-O', 'been-O', 'associated-O', 'with-O', 'paranoid-O', 'reactions-O', 'in-O', 'psychiatric-B-Disease', 'patients-O', '.-O']
['Five-O', 'cases-O', 'of-O', 'paranoid-B-Disease', 'exacerbation-O', 'with-O', 'the-O', 'serotonin-B-Chemical', 'reuptake-O', 'inhibitors-O', 'fluoxetine-B-Chemical', 'and-O', 'amitriptyline-B-Chemical', 'are-O', 'reported-O', 'here-O', '.-O']
['Elements-O', 'common-O', 'to-O', 'these-O', 'cases-O', 'included-O', 'a-O', 'history-O', 'of-O', 'paranoid-B-Disease', 'symptomatology-O', 'and-O', 'the-O', 'concomitant-O', 'occurrence-O', 'of-O', 'depressive-B-Disease', 'and-O', 'psychotic-B-Disease', 'symptoms-O', '.-O']
['Complicated-O', 'depressive-B-Disease', 'disorders-O', '(-O', 'including-O', 'atypicality-O', 'of-O', 'course-O', 'and-O', 'symptomatology-O', ',-O', 'chronicity-O', ',-O', 'psychosis-B-Disease', ',-O', 'bipolarity-B-Disease', ',-O', 'and-O', 'secondary-O', 'onset-O', 'in-O', 'the-O', 'course-O', 'of-O', 'a-O', 'primary-O', 'psychosis-B-Disease', ')-O', 'may-O', 'present-O', 'particular-O', 'vulnerability-O', 'to-O', 'paranoid-B-Disease', 'exacerbations-O', 'associated-O', 'with-O', 'serotonin-B-Chemical', 'reuptake-O', 'inhibitors-O', '.-O']
['Although-O', 'the-O', 'pharmacology-O', 'and-O', 'neurobiology-O', 'of-O', 'paranoia-O', 'remain-O', 'cryptic-O', ',-O', 'several-O', 'mechanisms-O', ',-O', 'including-O', '5HT3-O', 'receptor-O', ',-O', 'mediated-O', 'dopamine-B-Chemical', 'release-O', ',-O', 'beta-O', ',-O', 'noradrenergic-O', 'receptor-O', 'downregulation-O', ',-O', 'or-O', 'GABAB-O', 'receptor-O', 'upregulation-O', 'acting-O', 'in-O', 'the-O', 'vicinity-O', 'of-O', 'the-O', 'ventral-O', 'basal-O', 'ganglia-O', '(-O', 'possibly-O', 'in-O', 'lateral-O', 'orbitofrontal-O', 'or-O', 'anterior-O', 'cingulate-O', 'circuits-O', ')-O', 'might-O', 'apply-O', 'to-O', 'this-O', 'phenomenon-O', '.-O']
['These-O', 'cases-O', 'call-O', 'attention-O', 'to-O', 'possible-O', 'paranoid-B-Disease', 'exacerbations-O', 'with-O', 'serotonin-B-Chemical', 'reuptake-O', 'blockers-O', 'in-O', 'select-O', 'patients-O', 'and-O', 'raise-O', 'neurobiological-O', 'considerations-O', 'regarding-O', 'paranoia-B-Disease']
['Five-O', 'cases-O', 'of-O', 'encephalitis-B-Disease', 'during-O', 'treatment-O', 'of-O', 'loiasis-B-Disease', 'with-O', 'diethylcarbamazine-B-Chemical', '.-O']
['Five-O', 'cases-O', 'of-O', 'encephalitis-B-Disease', 'following-O', 'treatment-O', 'with-O', 'diethylcarbamazine-B-Chemical', '(-O', 'DEC-I-Chemical', ')', 'were-O', 'observed-O', 'in-O', 'Congolese-O', 'patients-O', 'with-O', 'Loa-O', 'loa-O', 'filariasis-B-Disease', '.-O']
['Two-O', 'cases-O', 'had-O', 'a-O', 'fatal-O', 'outcome-O', 'and-O', 'one-O', 'resulted-O', 'in-O', 'severe-O', 'sequelae-O', '.-O']
['The-O', 'notable-O', 'fact-O', 'was-O', 'that-O', 'this-O', 'complication-O', 'occurred-O', 'in-O', 'three-O', 'patients-O', 'hospitalized-O', 'before-O', 'treatment-O', 'began-O', ',-O', 'with-O', 'whom-O', 'particularly-O', 'strict-O', 'therapeutic-O', 'precautions-O', 'were-O', 'taken-O', ',-O', 'i-O', '.-O']
['e-O', '.-O', 'initial-O', 'dose-O', 'less-O', 'than-O', '10-O', 'mg-O', 'of-O', 'DEC-B-Chemical', ',-O', 'very-O', 'gradual-O', 'dose-O', 'increases-O', ',-O', 'and-O', 'associated-O', 'anti-O', ',-O', 'allergic-B-Disease', 'treatment-O', '.-O']
['This-O', 'type-O', 'of-O', 'drug-O', ',-O', 'induced-O', 'complication-O', 'may-O', 'not-O', 'be-O', 'that-O', 'uncommon-O', 'in-O', 'highly-O', 'endemic-O', 'regions-O', '.-O']
['It-O', 'occurs-O', 'primarily-O', ',-O', 'but-O', 'not-O', 'exclusively-O', ',-O', 'in-O', 'subjects-O', 'presenting-O', 'with-O', 'a-O', 'high-O', 'microfilarial-O', 'load-O', '.-O']
['The-O', 'relationship-O', 'between-O', 'the-O', 'occurrence-O', 'of-O', 'encephalitis-B-Disease', 'and-O', 'the-O', 'decrease-O', 'in-O', 'microfilaremia-O']
['Delirium-B-Disease', 'in-O', 'an-O', 'elderly-O', 'woman-O', 'possibly-O', 'associated-O', 'with-O', 'administration-O', 'of-O', 'misoprostol-B-Chemical', '.-O']
['Misoprostol-B-Chemical', 'has-O', 'been-O', 'associated-O', 'with-O', 'adverse-O', 'reactions-O', ',-O', 'including-O', 'gastrointestinal-O', 'symptoms-O', ',-O', 'gynecologic-O', 'problems-O', ',-O', 'and-O', 'headache-B-Disease', '.-O']
['Changes-O', 'in-O', 'mental-O', 'status-B-Disease', ',-O', 'however-O', ',-O', 'have-O', 'not-O', 'been-O', 'reported-O', '.-O']
['We-O', 'present-O', 'a-O', 'case-O', 'in-O', 'which-O', 'an-O', '89-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'in-O', 'a-O', 'long-O', ',-O', 'term-O', 'care-O', 'facility-O', 'became-O', 'confused-O', 'after-O', 'the-O', 'initiation-O', 'of-O', 'misoprostol-B-Chemical', 'therapy-O', '.-O']
['The-O', 'patient-O', 'x-O', 's-O', 'change-O', 'in-O', 'mental-O', 'status-O', 'was-O', 'first-O', 'reported-O', 'nine-O', 'days-O', 'after-O', 'the-O', 'initiation-O', 'of-O', 'therapy-O', '.-O']
['Her-O', 'delirium-B-Disease', 'significantly-O', 'improved-O', 'after-O', 'misoprostol-B-Chemical', 'was-O', 'discontinued-O', 'and-O', 'her-O', 'mental-O', 'status-O', 'returned-O', 'to-O', 'normal-O', 'within-O', 'a-O', 'week-O', '.-O']
['Because-O', 'no-O', 'other-O', 'factors-O', 'related-O', 'to-O', 'this-O', 'patient-O', 'changed-O', 'significantly-O', ',-O', 'the-O', 'delirium-B-Disease', 'experienced-O', 'by-O', 'this-O', 'patient-O', 'possibly-O', 'resulted-O', 'from-O', 'misoprostol-B-Chemical']
['Hepatocellular-B-Disease', 'oxidant-O', 'stress-O', 'following-O', 'intestinal-O', 'ischemia-B-Disease', ',-O', 'reperfusion-O', 'injury-O', '.-O']
['Reperfusion-O', 'of-O', 'ischemic-O', 'intestine-O', 'results-O', 'in-O', 'acute-O', 'liver-O', 'dysfunction-B-Disease', 'characterized-O', 'by-O', 'hepatocellular-O', 'enzyme-O', 'release-O', 'into-O', 'plasma-O', ',-O', 'reduction-O', 'in-O', 'bile-O', 'flow-O', 'rate-O', ',-O', 'and-O', 'neutrophil-O', 'sequestration-O', 'within-O', 'the-O', 'liver-O', '.-O']
['The-O', 'pathophysiology-O', 'underlying-O', 'this-O', 'acute-B-Disease', 'hepatic-I-Disease', 'injury-I-Disease', 'is-O', 'unknown-O', '.-O']
['This-O', 'study-O', 'was-O', 'undertaken-O', 'to-O', 'determine-O', 'whether-O', 'oxidants-O', 'are-O', 'associated-O', 'with-O', 'the-O', 'hepatic-B-Disease', 'injury-I-Disease', 'and-O', 'to-O', 'determine-O', 'the-O', 'relative-O', 'value-O', 'of-O', 'several-O', 'indirect-O', 'methods-O', 'of-O', 'assessing-O', 'oxidant-O', 'exposure-O', 'in-O', 'vivo-O', '.-O']
['Rats-O', 'were-O', 'subjected-O', 'to-O', 'a-O', 'standardized-O', 'intestinal-O', 'ischemia-B-Disease', ',-O', 'reperfusion-O', 'injury-O', '.-O']
['Hepatic-B-Disease', 'tissue-O', 'was-O', 'assayed-O', 'for-O', 'lipid-O', 'peroxidation-O', 'products-O', 'and-O', 'oxidized-O', 'and-O', 'reduced-O', 'glutathione-B-Chemical', '.-O']
['There-O', 'was-O', 'no-O', 'change-O', 'in-O', 'hepatic-O', 'tissue-O', 'total-O', 'glutathione-B-Chemical', 'following-O', 'intestinal-O', 'ischemia-B-Disease', ',', 'reperfusion-O', 'injury-O', '.-O']
['Oxidized-O', 'glutathione-B-Chemical', '(-O', 'GSSG-B-Chemical', ')-O', 'increased-O', 'significantly-O', 'following-O', '30-O', 'and-O', '60-O', 'min-O', 'of-O', 'reperfusion-O', '.-O']
['There-O', 'was-O', 'no-O', 'increase-O', 'in-O', 'any-O', 'of-O', 'the-O', 'products-O', 'of-O', 'lipid-O', 'peroxidation-O', 'associated-O', 'with-O', 'this-O', 'injury-I-Disease', '.-O']
['An-O', 'increase-O', 'in-O', 'GSSG-B-Chemical', 'within-O', 'hepatic-O', 'tissue-O', 'during-O', 'intestinal-O', 'reperfusion-O', 'suggests-O', 'exposure-O', 'of-O', 'hepatocytes-O', 'to-O', 'an-O', 'oxidant-O', 'stress-O', '.-O']
['The-O', 'lack-O', 'of-O', 'a-O', 'significant-O', 'increase-O', 'in-O', 'products-O', 'of-O', 'lipid-O', 'peroxidation-O', 'suggests-O', 'that-O', 'the-O', 'oxidant-O', 'stress-O', 'is-O', 'of-O', 'insufficient-O', 'magnitude-O', 'to-O', 'result-O', 'in-O', 'irreversible-O', 'injury-O', 'to-O', 'hepatocyte-O', 'cell-O', 'membranes-O', '.-O']
['These-O', 'data-O', 'also-O', 'suggest-O', 'that-O', 'the-O', 'measurement-O', 'of-O', 'tissue-O', 'GSSG-B-Chemical']
['Diphenhydramine-B-Chemical', 'prevents-O', 'the-O', 'haemodynamic-O', 'changes-O', 'of-O', 'cimetidine-B-Chemical', 'in-O', 'ICU-O', 'patients-O', '.-O']
['Cimetidine-B-Chemical', ',-O', 'a-O', 'histamine-B-Chemical', '2-O', '(-O', 'H2-O', ')-O', 'antagonist-O', ',-O', 'produces-O', 'a-O', 'decrease-O', 'in-O', 'arterial-O', 'pressure-O', 'due-O', 'to-O', 'vasodilatation-O', ',-O', 'especially-O', 'in-O', 'critically-O', 'ill-B-Disease', 'patients-O', '.-O']
['This-O', 'may-O', 'be-O', 'because-O', 'cimetidine-B-Chemical', 'acts-O', 'as-O', 'a-O', 'histamine-B-Chemical', 'agonist-O', '.-O']
['We-O', ',-O', 'therefore-O', ',-O', 'investigated-O', 'the-O', 'effects-O', 'of-O', 'the-O', 'histamine-B-Chemical', '1-O', '(-O', 'H1-O', ')-O', 'receptor-O', 'antagonist-O', ',-O', 'diphenhydramine-B-Chemical', ',-O', 'on-O', 'the-O', 'haemodynamic-O', 'changes-O', 'observed-O', 'after-O', 'cimetidine-B-Chemical', 'in-O', 'ICU-O', 'patients-O', '.-O']
['Each-O', 'patient-O', 'was-O', 'studied-O', 'on-O', 'two-O', 'separate-O', 'days-O', '.-O']
['In-O', 'a-O', 'random-O', 'fashion-O', ',-O', 'they-O', 'received-O', 'cimetidine-B-Chemical', '200-O', 'mg-O', 'iv-O', 'on-O', 'one-O', 'day-O', ',-O', 'and-O', 'on-O', 'the-O', 'other-O', ',-O', 'a-O', 'pretreatment-O', 'of-O', 'diphenhydramine-B-Chemical', '40-O', 'mg-O', 'iv-O', 'with-O', 'cimetidine-B-Chemical', '200-O', 'mg-O', 'iv-O', '.-O']
['In-O', 'the-O', 'non-O', ',-O', 'pretreatment-O', 'group-O', ',-O', 'mean-O', 'arterial-O', 'pressure-O', '(-O', 'MAP-O', ')-O', 'decreased-O', 'from-O', '107-O', '.-O']
['4-O', '+-O', '8-O', '.-O']
['4-O', 'mmHg-O', 'to-O', '86-O', '.-O']
['7-O', '+-O', '11-O', '.-O']
['4-O', 'mmHg-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ')-O', 'two-O', 'minutes-O', 'after-O', 'cimetidine-B-Chemical', '.-O']
['Also-O', ',-O', 'systemic-O', 'vascular-O', 'resistance-O', '(-O', 'SVR-O', ')-O', 'decreased-O', 'during-O', 'the-O', 'eight-O', ',-O', 'minute-O', 'observation-O', 'period-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ').-O', 'In-O', 'contrast-O', ',-O', 'in-O', 'the-O', 'pretreatment-O', 'group-O', ',-O', 'little-O', 'haemodynamic-O', 'change-O', 'was-O', 'seen-O', '.-O']
['We-O', 'conclude-O', 'that-O', 'an-O', 'H1-O', 'antagonist-O', 'may-O', 'be-O', 'useful-O', 'in-O', 'preventing-O', 'hypotension-B-Disease', 'caused-O', 'by-O', 'iv-O', 'cimetidine-B-Chemical', ',-O', 'since-O', 'the-O', 'vasodilating-O', 'activity-O', 'of-O', 'cimetidine-B-Chemical']
['Acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'due-O', 'to-O', 'rifampicin-B-Chemical', '.-O']
['A-O', '23-O', ',-O', 'year-O', ',-O', 'old-O', 'male-O', 'patient-O', 'with-O', 'bacteriologically-O', 'proven-O', 'pulmonary-B-Disease', 'tuberculosis-B-Disease', 'was-O', 'treated-O', 'with-O', 'the-O', 'various-O', 'regimens-O', 'of-O', 'antituberculosis-O', 'drugs-O', 'for-O', 'nearly-O', '15-O', 'months-O', '.-O']
['Rifampicin-B-Chemical', 'was-O', 'administered-O', 'thrice-O', 'as-O', 'one-O', 'of-O', 'the-O', '3-O', ',', '4-O', 'drug-O', 'regimen-O', 'and-O', 'each-O', 'time-O', 'he-O', 'developed-O', 'untoward-O', 'side-O', 'effects-O', 'like-O', 'nausea-B-Disease', ',', 'vomiting-B-Disease', 'and-O', 'fever-B-Disease']
['Severe-O', 'polyneuropathy-B-Disease', 'and-O', 'motor-O', 'loss-O', 'after-O', 'intrathecal-O', 'thiotepa-B-Chemical', 'combination-O', 'chemotherapy-O', ':-O', 'description-O', 'of-O', 'two-O', 'cases-O', '.-O']
['Two-O', 'cases-O', 'of-O', 'severe-O', 'delayed-O', 'neurologic-B-Disease', 'toxicity-I-Disease', 'related-O', 'to-O', 'the-O', 'administration-O', 'of-O', 'intrathecal-O', '(-O', 'IT-O', ')-O', 'combination-O', 'chemotherapy-O', 'including-O', 'thiotepa-B-Chemical', '(-O', 'TSPA-B-Chemical', ')-O', 'are-O', 'presented-O', '.-O']
['Both-O', 'cases-O', 'developed-O', 'axonal-B-Disease', 'neuropathy-I-Disease', 'with-O', 'motor-I-Disease', 'predominance-O', 'in-O', 'the-O', 'lower-O', 'extremities-O', '1-O', 'and-O', '6-O', 'months-O', 'after-O', 'IT-O', 'chemotherapy-O', 'was-O', 'administered-O', '.-O']
['Neurologic-O', 'toxicities-B-Disease', 'have-O', 'been-O', 'described-O', 'with-O', 'IT-O', ',-O', 'methotrexate-B-Chemical', ',-O', 'IT-O', ',-O', 'cytosine-O', 'arabinoside-B-Chemical', 'and-O', 'IT-O', ',-O', 'TSPA-B-Chemical', '.-O']
['To-O', 'our-O', 'knowledge-O', ',-O', 'however-O', ',-O', 'axonal-B-Disease', 'neuropathy-I-Disease', 'following-O', 'administration-O', 'of-O', 'these-O', 'three-O', 'agents-O', 'has-O', 'not-O', 'been-O', 'previously-O', 'described-O', '.-O']
['In-O', 'spite-O', 'of-O', 'the-O', 'fact-O', 'that-O', 'TSPA-B-Chemical', 'is-O', 'a-O', 'useful-O', 'IT-O', 'agent-O', ',-O', 'its-O', 'combination-O', 'with-O', 'MTX-B-Chemical', ',-O', 'ara-C-B-Chemical', 'and-O', 'radiotherapy-O', 'could-O', 'cause-O', 'severe-O', 'neurotoxicity-B-Disease', '.-O']
['This-O', 'unexpected-O', 'complication-O', 'indicates-O', 'the-O', 'need-O', 'for-O', 'further-O', 'toxicology-O', 'research-O', 'on-O', 'IT-O', ',-O', 'TSPA-O']
['Effects-O', 'of-O', 'cromakalim-B-Chemical', 'and-O', 'pinacidil-B-Chemical', 'on-O', 'large-O', 'epicardial-O', 'and-O', 'small-O', 'coronary-O', 'arteries-O', 'in-O', 'conscious-O', 'dogs-O', '.-O']
['The-O', 'effects-O', 'of-O', 'i-O', '.-O']
['v-O', '.-O']
['bolus-O', 'administration-O', 'of-O', 'cromakalim-B-Chemical', '(-O', '1-O', ',', '10-O', 'micrograms-O', '/-O', 'kg-O', ')-O', 'and-O', 'pinacidil-B-Chemical', '(-O', '3-O', ',', '100-O', 'micrograms-O', '/-O', 'kg-O', ')-O', 'on-O', 'large-O', '(-O', 'circumflex-O', 'artery-O', ')-O', 'and-O', 'small-O', 'coronary-O', 'arteries-O', 'and-O', 'on-O', 'systemic-O', 'hemodynamics-O', 'were-O', 'investigated-O', 'in-O', 'chronically-O', 'instrumented-O', 'conscious-O', 'dogs-O', 'and-O', 'compared-O', 'to-O', 'those-O', 'of-O', 'nitroglycerin-B-Chemical', '(-O', '0-O', '.-O']
['03-O', ',-O', '10-O', 'micrograms-O', '/-O', 'kg-O', ')-O', '.-O', 'Nitroglycerin-B-Chemical', ',-O', 'up-O', 'to-O', '0-O', '.-O']
['3-O', 'micrograms-O', '/-O', 'kg-O', ',-O', 'selectively-O', 'increased-O', 'circumflex-O', 'artery-O', 'diameter-O', '(-O', 'CxAD-O', ')-O', 'without-O', 'simultaneously-O', 'affecting-O', 'any-O', 'other-O', 'cardiac-O', 'or-O', 'systemic-O', 'hemodynamic-O', 'parameter-O', '.-O']
['In-O', 'contrast-O', ',-O', 'cromakalim-B-Chemical', 'and-O', 'pinacidil-B-Chemical', 'at-O', 'all-O', 'doses-O', 'and-O', 'nitroglycerin-B-Chemical', 'at-O', 'doses-O', 'higher-O', 'than-O', '0-O', '.-O']
['3-O', 'micrograms-O', '/-O', 'kg-O', 'simultaneously-O', 'and-O', 'dose-O', ',-O', 'dependently-O', 'increased-O', 'CxAD-O', ',-O', 'coronary-O', 'blood-O', 'flow-O', 'and-O', 'heart-O', 'rate-O', 'and-O', 'decreased-O', 'coronary-O', 'vascular-O', 'resistance-O', 'and-O', 'aortic-O', 'pressure-O', '.-O']
['Cromakalim-B-Chemical', 'was-O', 'approximately-O', '8-O', ',-O', 'to-O', '9-O', '.-O']
['5-O', ',-O', 'fold-O', 'more-O', 'potent-O', 'than-O', 'pinacidil-B-Chemical', 'in-O', 'increasing-O', 'CxAD-O', '.-O']
['Vasodilation-O', 'of-O', 'large-O', 'and-O', 'small-O', 'coronary-O', 'vessels-O', 'and-O', 'hypotension-B-Disease', 'induced-O', 'by-O', 'cromakalim-B-Chemical', 'and-O', 'pinacidil-B-Chemical', 'were-O', 'not-O', 'affected-O', 'by-O', 'prior-O', 'combined-O', 'beta-O', 'adrenergic-O', 'and-O', 'muscarinic-O', 'receptors-O', 'blockade-O', 'but-O', 'drug-O', ',-O', 'induced-O', 'tachycardia-B-Disease', 'was-O', 'abolished-O', '.-O']
['When-O', 'circumflex-O', 'artery-O', 'blood-O', 'flow-O', 'was-O', 'maintained-O', 'constant-O', ',-O', 'the-O', 'increases-O', 'in-O', 'CxAD-O', 'induced-O', 'by-O', 'cromakalim-B-Chemical', '(-O', '10-O', 'micrograms-O', '/-O', 'kg-O', ')-O', 'pinacidil-B-Chemical', '(-O', '30-O', 'micrograms-O', '/-O', 'kg-O', ')-O', 'and-O', 'nitroglycerin-B-Chemical', '(-O', '10-O', 'micrograms-O', '/-O', 'kg-O', ')-O', 'were-O', 'reduced-O', 'by-O', '68-O', '+-O', '7-O', ',-O', '54-O', '+-O', '9-O', 'and-O', '1-O', '+-O', '1-O', ',-O', 'respectively-O', '.-O']
['Thus-O', ',-O', 'whereas-O', 'nitroglycerin-B-Chemical', 'preferentially-O', 'and-O', 'flow-O', ',-O', 'independently-O', 'dilates-O', 'large-O', 'coronary-O', 'arteries-O', ',-O', 'cromakalim-B-Chemical', 'and-O', 'pinacidil-B-Chemical', 'dilate-O', 'both-O', 'large-O', 'and-O', 'small-O', 'coronary-O', 'arteries-O', 'and-O', 'this-O', 'effect-O', 'is-O', 'not-O', 'dependent-O', 'upon-O', 'the-O', 'simultaneous-O', 'beta-O', 'adrenoceptors-O', ',-O', 'mediated-O', 'rise-O', 'in-O', 'myocardial-O', 'metabolic-O', 'demand-O', '.-O']
['Finally-O', ',-O', 'two-O', 'mechanisms-O', 'at-O', 'least-O', ',-O', 'direct-O', 'vasodilation-O', 'and-O', 'flow-O', 'dependency-O', ',-O', 'are-O', 'involved-O', 'in-O', 'the-O', 'cromakalim-B-Chemical', ',-O', 'and-O', 'pinacidil-B-Chemical']
['Mefenamic-B-Chemical', 'acid-I-Chemical', ',-O', 'induced-O', 'neutropenia-B-Disease', 'and-O', 'renal-B-Disease', 'failure-I-Disease', 'in-O', 'elderly-O', 'females-O', 'with-O', 'hypothyroidism-B-Disease', '.-O']
['We-O', 'report-O', 'mefenamic-B-Chemical', 'acid-I-Chemical', ',-O', 'induced-O', 'non-O', ',-O', 'oliguric-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'and-O', 'severe-O', 'neutropenia-B-Disease', 'occurring-O', 'simultaneously-O', 'in-O', 'two-O', 'elderly-O', 'females-O', '.-O']
['The-O', 'neutropenia-B-Disease', 'was-O', 'due-O', 'to-O', 'maturation-O', 'arrest-O', 'of-O', 'the-O', 'myeloid-O', 'series-O', 'in-O', 'one-O', 'patient-O', '.-O']
['Both-O', 'patients-O', 'were-O', 'also-O', 'hypothyroid-B-Disease', ',-O', 'but-O', 'it-O', 'is-O', 'not-O', 'clear-O', 'whether-O', 'this-O', 'was-O', 'a-O', 'predisposing-O', 'factor-O', 'to-O', 'the-O', 'development-O', 'of-O', 'these-O', 'adverse-O', 'reactions-O', '.-O']
['However-O', ',-O', 'it-O', 'would-O', 'seem-O', 'prudent-O', 'not-O', 'to-O', 'use-O', 'mefenamic-B-Chemical', 'acid-I-Chemical', 'in-O', 'hypothyroid-B-Disease', 'patients-O', 'until-O', 'the-O', 'hypothyroidism-B-Disease']
['Etiology-O', 'of-O', 'hypercalcemia-B-Disease', 'in-O', 'hemodialysis-O', 'patients-O', 'on-O', 'calcium-B-Chemical', 'carbonate-I-Chemical', 'therapy-O', '.-O']
['Fourteen-O', 'of-O', '39-O', 'dialysis-O', 'patients-O', '(-O', '36-O', ')-O', 'became-O', 'hypercalcemic-B-Disease', 'after-O', 'switching-O', 'to-O', 'calcium-B-Chemical', 'carbonate-I-Chemical', 'as-O', 'their-O', 'principal-O', 'phosphate-B-Chemical', 'binder-O', '.-O']
['In-O', 'order-O', 'to-O', 'identify-O', 'risk-O', 'factors-O', 'associated-O', 'with-O', 'the-O', 'development-O', 'of-O', 'hypercalcemia-B-Disease', ',-O', 'indirect-O', 'parameters-O', 'of-O', 'intestinal-O', 'calcium-O', 'reabsorption-O', 'and-O', 'bone-O', 'turnover-O', 'rate-O', 'in-O', 'these-O', '14-O', 'patients-O', 'were-O', 'compared-O', 'with-O', 'results-O', 'in-O', '14-O', 'eucalcemic-O', 'patients-O', 'matched-O', 'for-O', 'age-O', ',-O', 'sex-O', ',-O', 'length-O', 'of-O', 'time-O', 'on-O', 'dialysis-O', ',-O', 'and-O', 'etiology-O', 'of-O', 'renal-O', 'disease-B-Disease', '.-O']
['In-O', 'addition-O', 'to-O', 'experiencing-O', 'hypercalcemic-B-Disease', 'episodes-O', 'with-O', 'peak-O', 'calcium-B-Chemical', 'values-O', 'of-O', '2-O', '.-O']
['7-O', 'to-O', '3-O', '.-O']
['8-O', 'mmol-O', '/-O', 'L-O', '(-O', '10-O', '.-O']
['7-O', 'to-O', '15-O', '.-O']
['0-O', 'mg-O', '/-O', 'dL-O', ')-O', 'patients-O', 'in-O', 'the-O', 'hypercalcemic-B-Disease', 'group-O', 'exhibited-O', 'a-O', 'significant-O', 'increase-O', 'in-O', 'the-O', 'mean-O', 'calcium-B-Chemical', 'concentration-O', 'obtained-O', 'during-O', '6-O', 'months-O', 'before-O', 'the-O', 'switch-O', ',-O', 'compared-O', 'with-O', 'the-O', 'mean-O', 'value-O', 'obtained-O', 'during-O', 'the-O', '7-O', 'months-O', 'of-O', 'observation-O', 'after-O', 'the-O', 'switch-O', '(-O', '2-O', '.-O']
['4-O', '+-O', '0-O', '.-O']
['03-O', 'to-O', '2-O', '.-O']
['5-O', '+-O', '0-O', '.-O']
['03-O', 'mmol-O', '/-O', 'L-O', '[-O', '9-O', '.-O']
['7-O', '+-O', '0-O', '.-O']
['2-O', 'to-O', '10-O', '.-O']
['2-O', '+-O', '0-O', '.-O']
['1-O', 'mg-O', '/-O', 'dL-O', ']-O', 'P-O', '=-O', '0-O', '.-O']
['006-O', ').-O', 'In-O', 'contrast-O', ',-O', 'eucalcemic-O', 'patients-O', 'exhibited-O', 'no-O', 'change-O', 'in-O', 'mean-O', 'calcium-B-Chemical', 'values-O', 'over-O', 'the-O', 'same-O', 'time-O', 'period-O', '(-O', '2-O', '.-O']
['3-O', '+-O', '0-O', '.-O']
['05-O', 'to-O', '2-O', '.-O']
['3-O', '+-O', '0-O', '.-O']
['05-O', 'mmol-O', '/-O', 'L-O', '[-O', '9-O', '.-O']
['2-O', '+-O', '0-O', '.-O']
['2-O', 'to-O', '9-O', '.-O']
['2-O', '+-O', '0-O', '.-O']
['2-O', 'mg-O', '/-O', 'dL-O', ')).-O', 'CaCO3-B-Chemical', 'dosage-O', ',-O', 'calculated-O', 'dietary-O', 'calcium-B-Chemical', 'intake-O', ',-O', 'and-O', 'circulating-O', 'levels-O', 'of-O', 'vitamin-B-Chemical', 'D-I-Chemical', 'metabolites-O', 'were-O', 'similar-O', 'in-O', 'both-O', 'groups-O', '.-O']
['Physical-O', 'activity-O', 'index-O', 'and-O', 'predialysis-O', 'serum-O', 'bicarbonate-B-Chemical']
['Methyldopa-B-Chemical', ',-O', 'induced-O', 'hemolytic-B-Disease', 'anemia-I-Disease', 'in-O', 'a-O', '15-O', 'year-O', 'old-O', 'presenting-O', 'as-O', 'near-O', ',-O', 'syncope-B-Disease', '.-O']
['Methyldopa-B-Chemical', 'is-O', 'an-O', 'antihypertensive-O', 'medication-O', 'which-O', 'is-O', 'available-O', 'generically-O', 'and-O', 'under-O', 'the-O', 'trade-O', 'name-O', 'Aldomet-O', 'that-O', 'is-O', 'widely-O', 'prescribed-O', 'in-O', 'the-O', 'adult-O', 'population-O', 'and-O', 'infrequently-O', 'used-O', 'in-O', 'children-O', '.-O']
['Methyldopa-B-Chemical', 'causes-O', 'an-O', 'autoimmune-B-Disease', 'hemolytic-B-Disease', 'anemia-I-Disease', 'in-O', 'a-O', 'small-O', 'percentage-O', 'of-O', 'patients-O', 'who-O', 'take-O', 'the-O', 'drug-O', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'methyldopa-B-Chemical', ',-O', 'induced-O', 'hemolytic-B-Disease', 'anemia-I-Disease', 'in-O', 'a-O', '15-O', ',-O', 'year-O', ',-O', 'old-O', 'boy-O', 'who-O', 'presented-O', 'to-O', 'the-O', 'emergency-O', 'department-O', 'with-O', 'near-O', ',-O', 'syncope-B-Disease', '.-O']
['The-O', 'boy-O', 'had-O', 'been-O', 'treated-O', 'with-O', 'intravenous-O', 'methyldopa-B-Chemical', 'during-O', 'a-O', 'trauma-B-Disease', 'admission-O', 'seven-O', 'weeks-O', 'prior-O', 'to-O', 'presentation-O', '.-O']
['Evaluation-O', 'revealed-O', 'a-O', 'hemoglobin-O', 'of-O', 'three-O', 'grams-O', ',-O', '3-O', '+-O', 'Coombs-O', 'x-O', 'test-O', 'with-O', 'polyspecific-O', 'anti-O', ',-O', 'human-O', 'globulin-O', 'and-O', 'monospecific-O', 'IgG-O', 'reagents-O', ',-O', 'and-O', 'a-O', 'warm-O', 'reacting-O', 'autoantibody-O', '.-O']
['Transfusion-O', 'and-O', 'corticosteroid-B-Chemical', 'therapy-O', 'resulted-O', 'in-O', 'a-O', 'complete-O', 'recovery-O', 'of-O', 'the-O', 'patient-O', '.-O']
['Emergency-O', 'physicians-O', 'treating-O', 'children-O', 'must-O', 'be-O', 'aware-O', 'of-O', 'this-O', 'syndrome-B-Disease', 'in-O', 'order-O', 'to-O', 'diagnose-O', 'and-O', 'treat-O', 'it-O', 'correctly-O', '.-O']
['A-O', 'brief-O', 'review-O', 'of-O', 'autoimmune-B-Disease', 'and-O', 'drug-O', ',-O', 'induced-O', 'hemolytic-B-Disease', 'anemias-I-Disease']
['The-O', 'long-O', ',-O', 'term-O', 'safety-O', 'of-O', 'danazol-B-Chemical', 'in-O', 'women-O', 'with-O', 'hereditary-B-Disease', 'angioedema-B-Disease', '.-O']
['Although-O', 'the-O', 'short-O', ',-O', 'term-O', 'safety-O', '(-O', 'less-O', 'than-O', 'or-O', 'equal-O', 'to-O', '6-O', 'months-O', ')-O', 'of-O', 'danazol-B-Chemical', 'has-O', 'been-O', 'established-O', 'in-O', 'a-O', 'variety-O', 'of-O', 'settings-O', ',-O', 'no-O', 'information-O', 'exists-O', 'as-O', 'to-O', 'its-O', 'long-O', ',-O', 'term-O', 'safety-O', '.-O']
['We-O', 'therefore-O', 'investigated-O', 'the-O', 'long-O', ',-O', 'term-O', 'safety-O', 'of-O', 'danazol-B-Chemical', 'by-O', 'performing-O', 'a-O', 'retrospective-O', 'chart-O', 'review-O', 'of-O', '60-O', 'female-O', 'patients-O', 'with-O', 'hereditary-B-Disease', 'angioedema-B-Disease', 'treated-O', 'with-O', 'danazol-B-Chemical', 'for-O', 'a-O', 'continuous-O', 'period-O', 'of-O', '6-O', 'months-O', 'or-O', 'longer-O', '.-O']
['The-O', 'mean-O', 'age-O', 'of-O', 'the-O', 'patients-O', 'was-O', '35-O', '.-O']
['2-O', 'years-O', 'and-O', 'the-O', 'mean-O', 'duration-O', 'of-O', 'therapy-O', 'was-O', '59-O', '.-O']
['7-O', 'months-O', '.-O']
['Virtually-O', 'all-O', 'patients-O', 'experienced-O', 'one-O', 'or-O', 'more-O', 'adverse-O', 'reactions-O', '.-O']
['Menstrual-O', 'abnormalities-O', '(-O', '79-O', '),', 'weight-O', 'gain-O', '(-O', '60-O', '),', 'muscle-O', 'cramps-O', '/-O', 'myalgias-O', '(-O', '40-O', '),', 'and-O', 'transaminase-O', 'elevations-O', '(-O', '40-O', ')', 'were-O', 'the-O', 'most-O', 'common-O', 'adverse-O', 'reactions-O', '.-O']
['The-O', 'drug-O', 'was-O', 'discontinued-O', 'due-O', 'to-O', 'adverse-O', 'reactions-O', 'in-O', '8-O', 'patients-O', '.-O']
['No-O', 'patient-O', 'has-O', 'died-O', 'or-O', 'suffered-O', 'any-O', 'apparent-O', 'long-O', ',-O', 'term-O', 'sequelae-O', 'that-O', 'were-O', 'directly-O', 'attributable-O', 'to-O', 'the-O', 'drug-O', '.-O']
['We-O', 'conclude-O', 'that-O', ',-O', 'despite-O', 'a-O', 'relatively-O', 'high-O', 'incidence-O', 'of-O', 'adverse-O', 'reactions-O', ',-O', 'danazol-B-Chemical']
['Patient-O', 'tolerance-O', 'study-O', 'of-O', 'topical-O', 'chlorhexidine-B-Chemical', 'diphosphanilate-B-Chemical', ':-O', 'a-O', 'new-O', 'topical-O', 'agent-O', 'for-O', 'burns-B-Disease', '.-O']
['Effective-O', 'topical-O', 'antimicrobial-O', 'agents-O', 'decrease-O', 'infection-B-Disease', 'and-O', 'mortality-O', 'in-O', 'burn-B-Disease', 'patients-O', '.-O']
['Chlorhexidine-B-Chemical', 'phosphanilate-B-Chemical', '(-O', 'CHP-B-Chemical', '), ,-O', 'a-O', 'new-O', 'broad-O', ',-O', 'spectrum-O', 'antimicrobial-O', 'agent-O', ',-O', 'has-O', 'been-O', 'evaluated-O', 'as-O', 'a-O', 'topical-O', 'burn-B-Disease', 'wound-B-Disease', 'dressing-O', 'in-O', 'cream-O', 'form-O', ',-O', 'but-O', 'preliminary-O', 'clinical-O', 'trials-O', 'reported-O', 'that-O', 'it-O', 'was-O', 'painful-O', 'upon-O', 'application-O', '.-O']
['This-O', 'study-O', 'compared-O', 'various-O', 'concentrations-O', 'of-O', 'CHP-B-Chemical', 'to-O', 'determine-O', 'if-O', 'a-O', 'tolerable-O', 'concentration-O', 'could-O', 'be-O', 'identified-O', 'with-O', 'retention-O', 'of-O', 'antimicrobial-O', 'efficacy-O', '.-O']
['Twenty-O', ',-O', 'nine-O', 'burn-B-Disease', 'patients-O', ',-O', 'each-O', 'with-O', 'two-O', 'similar-O', 'burns-B-Disease', 'which-O', 'could-O', 'be-O', 'separately-O', 'treated-O', ',-O', 'were-O', 'given-O', 'pairs-O', 'of-O', 'treatments-O', 'at-O', 'successive-O', '12-O', ',-O', 'h-O', 'intervals-O', 'over-O', 'a-O', '3-O', ',-O', 'day-O', 'period-O', '.-O']
['One-O', 'burn-O', 'site-O', 'was-O', 'treated-O', 'with-O', 'each-O', 'of-O', 'four-O', 'different-O', 'CHP-B-Chemical', 'concentrations-O', ',-O', 'from-O', '0-O', '.-O']
['25-O', 'per-O', 'cent-O', 'to-O', '2-O', 'per-O', 'cent-O', ',-O', 'their-O', 'vehicle-O', ',-O', 'and-O', '1-O', 'per-O', 'cent-O', 'silver-B-Chemical', 'sulphadiazine-B-Chemical', '(', 'AgSD-B-Chemical', ')-O', 'cream-O', ',-O', 'an-O', 'antimicrobial-O', 'agent-O', 'frequently-O', 'used-O', 'for-O', 'topical-O', 'treatment-O', 'of-O', 'burn-B-Disease', 'wounds-O', '.-O']
['The-O', 'other-O', 'site-O', 'was-O', 'always-O', 'treated-O', 'with-O', 'AgSD-B-Chemical', 'cream-O', '.-O']
['There-O', 'was-O', 'a-O', 'direct-O', 'relationship-O', 'between-O', 'CHP-O', 'concentration-O', 'and-O', 'patients-O', 'x-O', 'ratings-O', 'of-O', 'pain-B-Disease', 'on-O', 'an-O', 'analogue-O', 'scale-O', '.-O']
['The-O', '0-O', '.-O']
['25-O', 'per-O', 'cent-O', 'CHP-B-Chemical', 'cream-O', 'was-O', 'closest-O', 'to-O', 'AgSD-O', 'in-O', 'pain-B-Disease', 'tolerance-O', ';-O', 'however-O', ',-O', 'none-O', 'of-O', 'the-O', 'treatments-O', 'differed-O', 'statistically-O', 'from-O', 'AgSD-O', 'or-O', 'from-O', 'each-O', 'other-O', '.-O']
['In-O', 'addition-O', ',-O', 'ease-O', 'of-O', 'application-O', 'of-O', 'CHP-B-Chemical', 'creams-O', 'was-O', 'less-O', 'satisfactory-O', 'than-O', 'that-O', 'of-O', 'AgSD-B-Chemical', '.-O']
['It-O', 'was-O', 'concluded-O', 'that-O', 'formulations-O', 'at-O', 'or-O', 'below-O', '0-O', '.-O']
['5-O', 'per-O', 'cent-O', 'CHP-O']
['Dose-O', ',-O', 'dependent-O', 'neurotoxicity-B-Disease', 'of-O', 'high-O', ',-O', 'dose-O', 'busulfan-B-Chemical', 'in-O', 'children-O', ':-O', 'a-O', 'clinical-O', 'and-O', 'pharmacological-O', 'study-O', '.-O']
['Busulfan-B-Chemical', 'is-O', 'known-O', 'to-O', 'be-O', 'neurotoxic-B-Disease', 'in-O', 'animals-O', 'and-O', 'humans-O', ',-O', 'but-O', 'its-O', 'acute-O', 'neurotoxicity-B-Disease', 'remains-O', 'poorly-O', 'characterized-O', 'in-O', 'children-O', '.-O']
['We-O', 'report-O', 'here-O', 'a-O', 'retrospective-O', 'study-O', 'of-O', '123-O', 'children-O', '(-O', 'median-O', 'age-O', ',-O', '6-O', '.-O']
['5-O', 'years-O', ')-O', 'receiving-O', 'high-O', ',-O', 'dose-O', 'busulfan-B-Chemical', 'in-O', 'combined-O', 'chemotherapy-O', 'before-O', 'bone-O', 'marrow-O', 'transplantation-O', 'for-O', 'malignant-B-Disease', 'solid-O', 'tumors-I-Disease', ',-O', 'brain-O', 'tumors-I-Disease', 'excluded-O', '.-O']
['Busulfan-B-Chemical', 'was-O', 'given-O', 'p-O', '.-O']
['o-O', '.-O', 'every-O', '6-O', 'hours-O', 'for-O', '16-O', 'doses-O', 'over-O', '4-O', 'days-O', '.-O']
['Two-O', 'total-O', 'doses-O', 'were-O', 'consecutively-O', 'used-O', ':-O', '16-O', 'mg-O', '/-O', 'kg-O', ',-O', 'then-O', '600-O', 'mg-O', '/-O', 'm2-O', '.-O']
['The-O', 'dose-O', 'calculation-O', 'on-O', 'the-O', 'basis-O', 'of-O', 'body-O', 'surface-O', 'area-O', 'results-O', 'in-O', 'higher-O', 'doses-O', 'in-O', 'young-O', 'children-O', 'than-O', 'in-O', 'older-O', 'patients-O', '(-O', '16-O', 'to-O', '28-O', 'mg-O', '/-O', 'kg-O', ')-O', '.-O', 'Ninety-O', ',-O', 'six-O', 'patients-O', 'were-O', 'not-O', 'given-O', 'anticonvulsive-O', 'prophylaxis-O', ';-O', '7-O', '(-O', '7-O', '.-O']
['5-O', ')-O', 'developed-O', 'seizures-B-Disease', 'during-O', 'the-O', '4-O', 'days-O', 'of-O', 'the-O', 'busulfan-B-Chemical', 'course-O', 'or-O', 'within-O', '24-O', 'h-O', 'after-O', 'the-O', 'last-O', 'dosing-O', '.-O']
['When-O', 'the-O', 'total-O', 'busulfan-B-Chemical', 'dose-O', 'was-O', 'taken-O', 'into-O', 'account-O', ',-O', 'there-O', 'was-O', 'a-O', 'significant-O', 'difference-O', 'in-O', 'terms-O', 'of-O', 'neurotoxicity-B-Disease', 'incidence-O', 'among-O', 'patients-O', 'under-O', '16-O', 'mg-O', '/-O', 'kg-O', '(-O', '1-O', 'of-O', '57-O', ',-O', '1-O', '.-O']
['7-O', ')-O', 'and-O', 'patients-O', 'under-O', '600-O', 'mg-O', '/-O', 'm2-O', '(-O', '6-O', 'of-O', '39-O', ',-O', '15-O', '.-O']
['4-O', ')-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['02-O', ')-O', '.-O', 'Twenty-O', ',-O', 'seven-O', 'patients-O', 'were-O', 'given-O', 'a-O', '600-O', ',-O', 'mg-O', '/-O', 'm2-O', 'busulfan-B-Chemical', 'total-O', 'dose-O', 'with-O', 'continuous-O', 'i-O', '.-O']
['v-O', '.-O']
['infusion-O', 'of-O', 'clonazepam-B-Chemical', ';-O', 'none-O', 'had-O', 'any-O', 'neurological-O', 'symptoms-O', '.-O']
['Busulfan-B-Chemical', 'levels-O', 'were-O', 'measured-O', 'by-O', 'a-O', 'gas-O', 'chromatographic-O', ',-O', 'mass-O', 'spectrometry-O', 'assay-O', 'in-O', 'the-O', 'plasma-O', 'and-O', 'cerebrospinal-O', 'fluid-O', 'of-O', '9-O', 'children-O', 'without-O', 'central-O', 'nervous-O', 'system-O', 'disease-O', 'under-O', '600-O', 'mg-O', '/-O', 'm2-O', 'busulfan-B-Chemical', 'with-O', 'clonazepam-B-Chemical', ':-O', 'busulfan-B-Chemical', 'cerebrospinal-O', 'fluid-O', ':-O', 'plasma-O', 'ratio-O', 'was-O', '1-O', '.-O']
['39-O', '.-O']
['This-O', 'was-O', 'significantly-O', 'different-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['02-O', ')-O', 'from-O', 'the-O', 'cerebrospinal-O', 'fluid-O', ':-O', 'plasma-O', 'ratio-O', 'previously-O', 'defined-O', 'in-O', 'children-O', 'receiving-O', 'a-O', '16-O', ',', 'mg-O', '/-O', 'kg-O', 'total-O', 'dose-O', 'of-O', 'busulfan-B-Chemical', '.-O']
['This-O', 'study-O', 'shows-O', 'that-O', 'busulfan-B-Chemical', 'neurotoxicity-B-Disease', 'is-O', 'dose-O', ',-O', 'dependent-O', 'in-O', 'children-O', 'and-O', 'efficiently-O', 'prevented-O', 'by-O', 'clonazepam-B-Chemical', '.-O']
['A-O', 'busulfan-B-Chemical', 'dose-O', 'calculated-O', 'on-O', 'the-O', 'basis-O', 'of-O', 'body-O', 'surface-O', 'area-O', ',-O', 'resulting-O', 'in-O', 'higher-O', 'doses-O', 'in-O', 'young-O', 'children-O', ',-O', 'was-O', 'followed-O', 'by-O', 'increased-O', 'neurotoxicity-B-Disease', ',-O', 'close-O', 'to-O', 'neurotoxicity-B-Disease', 'incidence-O', 'observed-O', 'in-O', 'adults-O', '.-O']
['Since-O', 'plasma-O', 'pharmacokinetic-O', 'studies-O', 'showed-O', 'a-O', 'faster-O', 'busulfan-B-Chemical', 'clearance-O', 'in-O', 'children-O', 'than-O', 'in-O', 'adults-O', ',-O', 'this-O', 'new-O', 'dose-O', 'may-O', 'approximate-O', 'more-O', 'closely-O', 'the-O', 'adult-O', 'systemic-O', 'exposure-O', 'obtained-O', 'after-O', 'the-O', 'usual-O', '16-O', ',', 'mg-O', '/-O', 'kg-O', 'total-O', 'dose-O', ',-O', 'with-O', 'potential-O', 'inferences-O', 'in-O', 'terms-O', 'of-O', 'anticancer-O', 'or-O', 'myeloablative-O', 'effects-O', '.-O']
['The-O', 'busulfan-B-Chemical']
['Histamine-B-Chemical', 'antagonists-O', 'and-O', 'd-tubocurarine-B-Chemical', ',-O', 'induced-O', 'hypotension-B-Disease', 'in-O', 'cardiac-O', 'surgical-O', 'patients-O', '.-O']
['Hemodynamic-O', 'effects-O', 'and-O', 'histamine-B-Chemical', 'release-O', 'by-O', 'bolus-O', 'injection-O', 'of-O', '0-O', '.-O']
['35-O', 'mg-O', '/-O', 'kg-O', 'of-O', 'd-tubocurarine-B-Chemical', 'were-O', 'studied-O', 'in-O', '24-O', 'patients-O', '.-O']
['H1-O', ',-O', 'and-O', 'H2-O', ',-O', 'histamine-B-Chemical', 'antagonists-O', 'or-O', 'placebo-O', 'were-O', 'given-O', 'before-O', 'dosing-O', 'with-O', 'd-tubocurarine-B-Chemical', 'in-O', 'a-O', 'randomized-O', 'double-O', ',-O', 'blind-O', 'fashion-O', 'to-O', 'four-O', 'groups-O', ':-O', 'group-O', '1-O', '--O', 'placebo-O', ';-O', 'group-O', '2-O', '--O', 'cimetidine-B-Chemical', ',-O', '4-O', 'mg-O', '/-O', 'kg-O', ',-O', 'plus-O', 'placebo-O', ';-O', 'group-O', '3-O', '--O', 'chlorpheniramine-B-Chemical', ',-O', '0-O', '.-O']
['1-O', 'mg-O', '/-O', 'kg-O', ',-O', 'plus-O', 'placebo-O', ';-O', 'and-O', 'group-O', '4-O', '--O', 'cimetidine-B-Chemical', 'plus-O', 'chlorpheniramine-B-Chemical', '.-O']
['Histamine-B-Chemical', 'release-O', 'occurred-O', 'in-O', 'most-O', 'patients-O', ',-O', 'the-O', 'highest-O', 'level-O', '2-O', 'minutes-O', 'after-O', 'd-tubocurarine-B-Chemical', 'dosing-O', '.-O']
['Group-O', '1-O', 'had-O', 'a-O', 'moderate-O', 'negative-O', 'correlation-O', 'between-O', 'plasma-O', 'histamine-B-Chemical', 'change-O', 'and-O', 'systemic-O', 'vascular-O', 'resistance-O', '(-O', 'r-O', '=-O', '0-O', '.-O']
['58-O', ';-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ')-O', 'not-O', 'present-O', 'in-O', 'group-O', '4-O', '.-O']
['Prior-O', 'dosing-O', 'with-O', 'antagonists-O', 'partially-O', 'prevented-O', 'the-O', 'fall-O', 'in-O', 'systemic-O', 'vascular-O', 'resistance-O', '.-O']
['These-O', 'data-O', 'demonstrate-O', 'that-O', 'the-O', 'hemodynamic-O', 'changes-O', 'associated-O', 'with-O', 'd-tubocurarine-B-Chemical', 'dosing-O', 'are-O', 'only-O', 'partially-O', 'explained-O', 'by-O', 'histamine-B-Chemical']
['Convulsant-O', 'effect-O', 'of-O', 'lindane-B-Chemical', 'and-O', 'regional-O', 'brain-O', 'concentration-O', 'of-O', 'GABA-B-Chemical', 'and-O', 'dopamine-B-Chemical', '.-O']
['Lindane-B-Chemical', '(-O', 'gamma-hexachlorocyclohexane-B-Chemical', ')-O', 'is-O', 'an-O', 'organochlorine-O', 'insecticide-O', 'with-O', 'known-O', 'neurotoxic-B-Disease', 'effects-O', '.-O']
['Its-O', 'mechanism-O', 'of-O', 'action-O', 'is-O', 'not-O', 'well-O', 'understood-O', 'although-O', 'it-O', 'has-O', 'been-O', 'proposed-O', 'that-O', 'lindane-B-Chemical', 'acts-O', 'as-O', 'a-O', 'non-O', ',-O', 'competitive-O', 'antagonist-O', 'at-O', 'the-O', 'gamma-aminobutyric-B-Chemical', 'acid-I-Chemical', '(-O', 'GABA-B-Chemical', ')-O', 'A-O', 'receptor-O', '.-O']
['We-O', 'studied-O', 'the-O', 'effect-O', 'of-O', 'lindane-B-Chemical', '(-O', '150-O', 'mg-O', '/-O', 'kg-O', ')-O', 'on-O', 'the-O', 'GABAergic-O', 'and-O', 'dopaminergic-O', 'systems-O', 'by-O', 'measuring-O', 'the-O', 'concentration-O', 'of-O', 'GABA-B-Chemical', ',-O', 'dopamine-B-Chemical', 'and-O', 'its-O', 'metabolites-O', 'in-O', '7-O', 'brain-O', 'areas-O', 'at-O', 'the-O', 'onset-O', 'of-O', 'seizures-B-Disease', '.-O']
['All-O', 'animals-O', 'suffered-O', 'tonic-O', 'convulsions-B-Disease', 'at-O', '18-O', '.-O']
['3-O', '+-O', '1-O', '.-O']
['4-O', 'min-O', 'after-O', 'lindane-B-Chemical', 'administration-O', '.-O']
['The-O', 'concentration-O', 'of-O', 'GABA-B-Chemical', 'was-O', 'only-O', 'slightly-O', 'but-O', 'significantly-O', 'decreased-O', 'in-O', 'the-O', 'colliculi-O', 'without-O', 'modifications-O', 'in-O', 'the-O', 'other-O', 'areas-O', '.-O']
['The-O', 'concentration-O', 'of-O', 'dopamine-B-Chemical', 'was-O', 'increased-O', 'in-O', 'the-O', 'mesencephalon-O', 'and-O', 'that-O', 'of-O', 'its-O', 'metabolite-O', 'DOPAC-B-Chemical']
['Unusual-O', 'complications-O', 'of-O', 'antithyroid-O', 'drug-O', 'therapy-O', ':-O', 'four-O', 'case-O', 'reports-O', 'and-O', 'review-O', 'of-O', 'literature-O', '.-O']
['Two-O', 'cases-O', 'of-O', 'propylthiouracil-B-Chemical', ',-O', 'associated-O', 'acute-O', 'hepatitis-B-Disease', ',-O', 'one-O', 'case-O', 'of-O', 'fatal-O', 'methimazole-B-Chemical', ',-O', 'associated-O', 'hepatocellular-O', 'necrosis-B-Disease', 'and-O', 'one-O', 'case-O', 'of-O', 'propylthiouracil-B-Chemical', ',-O', 'associated-O', 'lupus-like-B-Disease', 'syndrome-O', 'are-O', 'described-O', '.-O']
['The-O', 'literature-O', 'related-O', 'to-O', 'antithyroid-O', 'drug-O', 'side-O', 'effects-O', 'and-O', 'the-O', 'mechanisms-O', 'for-O', 'their-O', 'occurrence-O', 'are-O', 'reviewed-O', 'and-O', 'the-O', 'efficacy-O', 'and-O', 'complications-O', 'of-O', 'thyroidectomy-O', 'and-O', 'radioiodine-O', 'compared-O', 'to-O', 'those-O', 'of-O', 'antithyroid-O', 'drugs-O', '.-O']
['It-O', 'is-O', 'concluded-O', 'that-O', 'in-O', 'most-O', 'circumstances-O', '131I-O', 'is-O', 'the-O', 'therapy-O', 'of-O', 'choice-O', 'for-O', 'hyperthyroidism-B-Disease']
['Anticonvulsant-O', 'actions-O', 'of-O', 'MK-801-B-Chemical', 'on-O', 'the-O', 'lithium-B-Chemical', ',-O', 'pilocarpine-B-Chemical', 'model-O', 'of-O', 'status-B-Disease', 'epilepticus-I-Disease', 'in-O', 'rats-O', '.-O']
['MK-801-B-Chemical', ',-O', 'a-O', 'noncompetitive-O', 'N-methyl-D-aspartate-B-Chemical', '(-O', 'NMDA-B-Chemical', ')-O', 'receptor-O', 'antagonist-O', ',-O', 'was-O', 'tested-O', 'for-O', 'anticonvulsant-O', 'effects-O', 'in-O', 'rats-O', 'using-O', 'two-O', 'seizure-O', 'models-O', ',-O', 'coadministration-O', 'of-O', 'lithium-B-Chemical', 'and-O', 'pilocarpine-B-Chemical', 'and-O', 'administration-O', 'of-O', 'a-O', 'high-O', 'dose-O', 'of-O', 'pilocarpine-B-Chemical', 'alone-O', '.-O']
['Three-O', 'major-O', 'results-O', 'are-O', 'reported-O', '.-O']
['First-O', ',-O', 'pretreatment-O', 'with-O', 'MK-801-B-Chemical', 'produced-O', 'an-O', 'effective-O', 'and-O', 'dose-O', ',-O', 'dependent-O', 'anticonvulsant-O', 'action-O', 'with-O', 'the-O', 'lithium-B-Chemical', ',-O', 'pilocarpine-B-Chemical', 'model-O', 'but-O', 'not-O', 'with-O', 'rats-O', 'treated-O', 'with-O', 'pilocarpine-B-Chemical', 'alone-O', ',-O', 'suggesting-O', 'that-O', 'different-O', 'biochemical-O', 'mechanisms-O', 'control-O', 'seizures-B-Disease', 'in-O', 'these-O', 'two-O', 'models-O', '.-O']
['Second-O', ',-O', 'the-O', 'anticonvulsant-O', 'effect-O', 'of-O', 'MK-801-B-Chemical', 'in-O', 'the-O', 'lithium-B-Chemical', ',-O', 'pilocarpine-B-Chemical', 'model-O', 'only-O', 'occurred-O', 'after-O', 'initial-O', 'periods-O', 'of-O', 'seizure-B-Disease', 'activity-O', '.-O']
['This-O', 'observation-O', 'is-O', 'suggested-O', 'to-O', 'be-O', 'an-O', 'in-O', 'vivo-O', 'demonstration-O', 'of-O', 'the-O', 'conclusion-O', 'derived-O', 'from-O', 'in-O', 'vitro-O', 'experiments-O', 'that-O', 'MK-801-B-Chemical', 'binding-O', 'requires-O', 'agonist-O', ',-O', 'induced-O', 'opening-O', 'of-O', 'the-O', 'channel-O', 'sites-O', 'of-O', 'the-O', 'NMDA-B-Chemical', 'receptor-O', '.-O']
['Third-O', ',-O', 'although-O', 'it-O', 'is-O', 'relatively-O', 'easy-O', 'to-O', 'block-O', 'seizures-B-Disease', 'induced-O', 'by-O', 'lithium-B-Chemical', 'and-O', 'pilocarpine-B-Chemical', 'by-O', 'administration-O', 'of-O', 'anticonvulsants-O', 'prior-O', 'to-O', 'pilocarpine-B-Chemical', ',-O', 'it-O', 'is-O', 'more-O', 'difficult-O', 'to-O', 'terminate-O', 'ongoing-O', 'status-B-Disease', 'epilepticus-I-Disease', 'and-O', 'block-O', 'the-O', 'lethality-O', 'of-O', 'the-O', 'seizures-B-Disease', '.-O']
['Administration-O', 'of-O', 'MK-801-B-Chemical', '30-O', 'or-O', '60-O', 'min-O', 'after-O', 'pilocarpine-B-Chemical', ',-O', 'i-O', '.-O']
['e-O', '.-O', 'during-O', 'status-B-Disease', 'epilepticus-I-Disease', ',-O', 'gradually-O', 'reduced-O', 'electrical-O', 'and-O', 'behavioral-O', 'seizure-B-Disease', 'activity-O', 'and-O', 'greatly-O', 'enhanced-O', 'the-O', 'survival-O', 'rate-O', '.-O']
['These-O', 'results-O', 'suggest-O', 'that-O', 'activation-O', 'of-O', 'NMDA-B-Chemical', 'receptors-O', 'plays-O', 'an-O', 'important-O', 'role-O', 'in-O', 'status-B-Disease', 'epilepticus-I-Disease', 'and-O', 'brain-O', 'damage-I-Disease', 'in-O', 'the-O', 'lithium-B-Chemical', ',-O', 'pilocarpine-B-Chemical', 'model-O', '.-O']
['This-O', 'was-O', 'further-O', 'supported-O', 'by-O', 'results-O', 'showing-O', 'that-O', 'nonconvulsive-O', 'doses-O', 'of-O', 'NMDA-B-Chemical', 'and-O', 'pilocarpine-B-Chemical', 'were-O', 'synergistic-O', ',-O', 'resulting-O', 'in-O', 'status-B-Disease', 'epilepticus-I-Disease']
['Nifedipine-B-Chemical', 'induced-O', 'bradycardia-B-Disease', 'in-O', 'a-O', 'patient-O', 'with-O', 'autonomic-B-Disease', 'neuropathy-I-Disease', '.-O']
['An-O', '80-O', 'year-O', 'old-O', 'diabetic-B-Disease', 'male-O', 'with-O', 'evidence-O', 'of-O', 'peripheral-B-Disease', 'and-O', 'autonomic-B-Disease', 'neuropathy-I-Disease', 'was-O', 'admitted-O', 'with-O', 'chest-B-Disease', 'pain-I-Disease', '.-O']
['He-O', 'was-O', 'found-O', 'to-O', 'have-O', 'atrial-B-Disease', 'flutter-I-Disease', 'at-O', 'a-O', 'ventricular-B-Disease', 'rate-O', 'of-O', '70-O', '/-O', 'min-O', 'which-O', 'slowed-O', 'down-O', 'to-O', '30-O', ',-O', '40-O', '/-O', 'min-O', 'when-O', 'nifedipine-B-Chemical', '(-O', '60-O', 'mg-O', ')-O', 'in-O', '3-O', 'divided-O', 'doses-O', ',-O', 'during-O', 'which-O', 'he-O', 'was-O', 'paced-O', 'at-O', 'a-O', 'rate-O', 'of-O', '70-O', '/-O', 'min-O', '.-O']
['This-O', 'is-O', 'inconsistent-O', 'with-O', 'the-O', 'well-O', ',-O', 'established-O', 'finding-O', 'that-O', 'nifedipine-B-Chemical', 'induces-O', 'tachycardia-B-Disease', 'in-O', 'normally-O', 'innervated-O', 'hearts-O', '.-O']
['However-O', ',-O', 'in-O', 'hearts-O', 'deprived-O', 'of-O', 'compensatory-O', 'sympathetic-O', 'drive-O', ',-O', 'it-O', 'may-O', 'lead-O', 'to-O', 'bradycardia-B-Disease']
['The-O', 'effect-O', 'of-O', 'haloperidol-B-Chemical', 'in-O', 'cocaine-B-Chemical', 'and-O', 'amphetamine-B-Chemical', 'intoxication-O', '.-O']
['The-O', 'effectiveness-O', 'of-O', 'haloperidol-B-Chemical', 'pretreatment-O', 'in-O', 'preventing-O', 'the-O', 'toxic-O', 'effects-O', 'of-O', 'high-O', 'doses-O', 'of-O', 'amphetamine-B-Chemical', 'and-O', 'cocaine-B-Chemical', 'was-O', 'studied-O', 'in-O', 'rats-O', '.-O']
['In-O', 'this-O', 'model-O', ',-O', 'toxic-O', 'effects-O', 'were-O', 'induced-O', 'by-O', 'intraperitoneal-O', '(-O', 'i-O', '.-O']
['p-O', ')-O', 'injection-O', 'of-O', 'amphetamine-B-Chemical', '75-O', 'mg-O', '/-O', 'kg-O', '(-O', '100-O', '%-O', 'death-O', 'rate-O', ')-O', 'or-O', 'cocaine-B-Chemical', '70-O', 'mg-O', '/-O', 'kg-O', '(-O', '82-O', '%-O', 'death-O', 'rate-O', ')-O', '.', 'Haloperidol-B-Chemical', 'failed-O', 'to-O', 'prevent-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', ',-O', 'but-O', 'did-O', 'lower-O', 'the-O', 'mortality-O', 'rate-O', 'at-O', 'most-O', 'doses-O', 'tested-O', '.-O']
['Haloperidol-B-Chemical', 'decreased-O', 'the-O', 'incidence-O', 'of-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', 'at-O', 'the-O', 'two-O', 'highest-O', 'doses-O', ',-O', 'but-O', 'the-O', 'lowering-O', 'of-O', 'the-O', 'mortality-O', 'rate-O', 'did-O', 'not-O', 'reach-O', 'statistical-O', 'significance-O', 'at-O', 'any-O', 'dose-O', '.-O']
['These-O', 'data-O', 'suggest-O', 'a-O', 'protective-O', 'role-O', 'for-O', 'the-O', 'central-O', 'dopamine-O', 'blocker-O', 'haloperidol-B-Chemical', 'against-O', 'death-B-Disease', 'from-O', 'high-O', 'dose-O', 'amphetamine-B-Chemical', 'exposure-O', 'without-O', 'reducing-O', 'the-O', 'incidence-O', 'of-O', 'seizures-B-Disease', '.-O']
['In-O', 'contrast-O', ',-O', 'haloperidol-B-Chemical', 'demonstrated-O', 'an-O', 'ability-O', 'to-O', 'reduce-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease']
['Autoradiographic-O', 'evidence-O', 'of-O', 'estrogen-B-Chemical', 'binding-O', 'sites-O', 'in-O', 'nuclei-O', 'of-O', 'diethylstilbesterol-B-Chemical', 'induced-O', 'hamster-O', 'renal-O', 'carcinomas-B-Disease', '.-O']
['Estrogen-B-Chemical', 'binding-O', 'sites-O', 'were-O', 'demonstrated-O', 'by-O', 'autoradiography-O', 'in-O', 'one-O', 'transplantable-O', 'and-O', 'five-O', 'primary-O', 'diethylstilbesterol-B-Chemical', 'induced-O', 'renal-O', 'carcinomas-I-Disease', 'in-O', 'three-O', 'hamsters-O', '.-O']
['Radiolabelling-O', ',-O', 'following-O', 'the-O', 'in-O', 'vivo-O', 'injection-O', 'of-O', '3H-B-Chemical', ',-O', '17-O', 'beta-O', 'estradiol-B-Chemical', ',-O', 'was-O', 'increased-O', 'only-O', 'over-O', 'the-O', 'nuclei-O', 'of-O', 'tumor-B-Disease', 'cells-O', ';-O', 'stereologic-O', 'analysis-O', 'revealed-O', 'a-O', '4-O', '.-O']
['5-O', ',-O', 'to-O', '6-O', '.-O']
['7-O', ',-O', 'times-O', 'higher-O', 'concentration-O', 'of-O', 'reduced-O', 'silver-B-Chemical', 'grains-O', 'over-O', 'nuclei-O', 'than-O', 'cytoplasm-O', 'of-O', 'these-O', 'cells-O', '.-O']
['Despite-O', 'rapid-O', 'tubular-O', 'excretion-O', 'of-O', 'estradiol-B-Chemical', 'which-O', 'peaked-O', 'in-O', 'less-O', 'than-O', '1-O', 'h-O', ',-O', 'the-O', 'normal-O', 'cells-O', 'did-O', 'not-O', 'appear-O', 'to-O', 'bind-O', 'the-O', 'ligand-O', '.-O']
['This-O', 'is-O', 'the-O', 'first-O', 'published-O', 'report-O', 'documenting-O', 'the-O', 'preferential-O', 'in-O', 'vivo-O', 'binding-O', 'of-O', 'estrogen-B-Chemical', 'to-O', 'nuclei-O', 'of-O', 'cells-O', 'in-O', 'estrogen-B-Chemical', 'induced-O', 'hamster-O', 'renal-O', 'carcinomas-B-Disease']
['Bradycardia-B-Disease', 'due-O', 'to-O', 'biperiden-B-Chemical', '.-O']
['In-O', 'a-O', '38-O', ',-O', 'year-O', ',-O', 'old-O', 'male-O', 'patient-O', 'suffering-O', 'from-O', 'a-O', 'severe-O', 'postzosteric-O', 'trigeminal-O', 'neuralgia-B-Disease', ',-O', 'intravenous-O', 'application-O', 'of-O', '10-O', 'mg-O', 'biperiden-B-Chemical', 'lactate-I-Chemical', 'led-O', 'to-O', 'a-O', 'long-O', ',-O', 'lasting-O', 'paradoxical-O', 'reaction-O', 'characterized-O', 'by-O', 'considerable-O', 'bradycardia-B-Disease', ',-O', 'dysarthria-B-Disease', ',-O', 'and-O', 'dysphagia-B-Disease', '.-O']
['The-O', 'heart-O', 'rate-O', 'was-O', 'back-O', 'to-O', 'normal-O', 'within-O', '12-O', 'hours-O', 'upon-O', 'administration-O', 'of-O', 'orciprenaline-B-Chemical', 'under-O', 'cardiac-O', 'monitoring-O', 'in-O', 'an-O', 'intensive-O', 'care-O', 'unit-O', '.-O']
['Bradycardia-B-Disease', 'induced-O', 'by-O', 'biperiden-B-Chemical', 'is-O', 'attributed-O', 'to-O', 'the-O', 'speed-O', 'of-O', 'injection-O', 'and-O', 'to-O', 'a-O', 'dose-O', ',-O', 'related-O', 'dual-O', 'effect-O', 'of-O', 'atropine-B-Chemical', ',-O', 'like-O', 'drugs-O', 'on-O', 'muscarine-B-Chemical']
['Deliberate-O', 'hypotension-B-Disease', 'induced-O', 'by-O', 'labetalol-B-Chemical', 'with-O', 'halothane-B-Chemical', ',-O', 'enflurane-B-Chemical', 'or-O', 'isoflurane-B-Chemical', 'for-O', 'middle-O', ',-O', 'ear-O', 'surgery-O', '.-O']
['The-O', 'feasibility-O', 'of-O', 'using-O', 'labetalol-B-Chemical', ',-O', 'an-O', 'alpha-O', ',-O', 'and-O', 'beta-O', ',-O', 'adrenergic-O', 'blocking-O', 'agent-O', ',-O', 'as-O', 'a-O', 'hypotensive-B-Disease', 'agent-O', 'in-O', 'combination-O', 'with-O', 'inhalation-O', 'anaesthetics-O', '(-O', 'halothane-B-Chemical', ',-O', 'enflurane-B-Chemical', 'or-O', 'isoflurane-B-Chemical', ')-O', 'was-O', 'studied-O', 'in-O', '23-O', 'adult-O', 'patients-O', 'undergoing-O', 'middle-O', ',-O', 'ear-O', 'surgery-O', '.-O']
['The-O', 'mean-O', 'arterial-O', 'pressure-O', 'was-O', 'decreased-O', 'from-O', '86-O', '+-O', '5-O', '(-O', 's-O', '.-O']
['e-O', '.-O']
['mean-O', ')-O', 'mmHg-O', 'to-O', '52-O', '+-O', '1-O', 'mmHg-O', '(-O', '11-O', '.-O']
['5-O', '+-O', '0-O', '.-O']
['7-O', 'to-O', '6-O', '.-O']
['9-O', '+-O', '0-O', '.-O']
['1-O', 'kPa-O', ')-O', 'for-O', '98-O', '+-O', '10-O', 'min-O', 'in-O', 'the-O', 'halothane-B-Chemical', '(-O', 'H-O', ')-O', 'group-O', ',-O', 'from-O', '79-O', '+-O', '5-O', 'to-O', '53-O', '+-O', '1-O', 'mmHg-O', '(-O', '10-O', '.-O']
['5-O', '+-O', '0-O', '.-O']
['7-O', 'to-O', '7-O', '.-O']
['1-O', '+-O', '0-O', '.-O']
['1-O', 'kPa-O', ')-O', 'for-O', '129-O', '+-O', '11-O', 'min-O', 'in-O', 'the-O', 'enflurane-B-Chemical', '(-O', 'E-O', ')-O', 'group-O', ',-O', 'and-O', 'from-O', '80-O', '+-O', '4-O', 'to-O', '49-O', '+-O', '1-O', 'mmHg-O', '(-O', '10-O', '.-O']
['7-O', '+-O', '0-O', '.-O']
['5-O', 'to-O', '6-O', '.-O']
['5-O', '+-O', '0-O', '.-O']
['1-O', 'kPa-O', ')-O', 'for-O', '135-O', '+-O', '15-O', 'min-O', 'in-O', 'the-O', 'isoflurane-B-Chemical', '(-O', 'I-O', ')-O', 'group-O', '.-O']
['The-O', 'mean-O', 'H-B-Chemical', 'concentration-O', 'during-O', 'hypotension-B-Disease', 'in-O', 'the-O', 'inspiratory-O', 'gas-O', 'was-O', '0-O', '.-O']
['7-O', '+-O', '0-O', '.-O']
['1-O', 'vol-O', ',-O', 'the-O', 'mean-O', 'E-O', 'concentration-O', '1-O', '.-O']
['6-O', '+-O', '0-O', '.-O']
['2-O', 'vol-O', ',-O', 'and-O', 'the-O', 'mean-O', 'I-B-Chemical', 'concentration-O', '1-O', '.-O']
['0-O', '+-O', '0-O', '.-O']
['1-O', 'vol-O', '.-O', 'In-O', 'addition-O', ',-O', 'the-O', 'patients-O', 'received-O', 'fentanyl-B-Chemical', 'and-O', 'd-tubocurarine-B-Chemical', '.-O']
['The-O', 'initial-O', 'dose-O', 'of-O', 'labetalol-B-Chemical', 'for-O', 'lowering-O', 'blood-O', 'pressure-O', 'was-O', 'similar-O', ',-O', '0-O', '.-O']
['52-O', ',-O', '0-O', '.-O']
['59-O', 'mg-O', '/-O', 'kg-O', ',-O', 'in-O', 'all-O', 'the-O', 'groups-O', '.-O']
['During-O', 'hypotension-B-Disease', ',-O', 'the-O', 'heart-O', 'rate-O', 'was-O', 'stable-O', 'without-O', 'tachy-O', '-O', 'or-O', 'bradycardia-B-Disease', '.-O']
['The-O', 'operating-O', 'conditions-O', 'regarding-O', 'bleeding-O', 'were-O', 'estimated-O', 'in-O', 'a-O', 'double-O', ',-O', 'blind-O', 'manner-O', ',-O', 'and-O', 'did-O', 'not-O', 'differ-O', 'significantly-O', 'between-O', 'the-O', 'groups-O', '.-O']
['During-O', 'hypotension-B-Disease', ',-O', 'the-O', 'serum-O', 'creatinine-B-Chemical', 'concentration-O', 'rose-O', 'significantly-O', 'in-O', 'all-O', 'groups-O', 'from-O', 'the-O', 'values-O', 'before-O', 'hypotension-B-Disease', 'and-O', 'returned-O', 'postoperatively-O', 'to-O', 'the-O', 'initial-O', 'level-O', 'in-O', 'the-O', 'other-O', 'groups-O', ',-O', 'except-O', 'the-O', 'isoflurane-B-Chemical', 'group-O', '.-O']
['After-O', 'hypotension-B-Disease', 'there-O', 'was-O', 'no-O', 'rebound-O', 'phenomenon-O', 'in-O', 'either-O', 'blood-O', 'pressure-O', 'or-O', 'heart-O', 'rate-O', '.-O']
['These-O', 'results-O', 'indicate-O', 'that-O', 'labetalol-B-Chemical', 'induces-O', 'easily-O', 'adjustable-O', 'hypotension-B-Disease', 'without-O', 'compensatory-O', 'tachycardia-B-Disease', 'and-O', 'rebound-O', 'hypertension-B-Disease']
['Convulsion-B-Disease', 'following-O', 'intravenous-O', 'fluorescein-B-Chemical', 'angiography-O', '.-O']
['Tonic-clonic-B-Disease', 'seizures-I-Disease', 'followed-O', 'intravenous-O', 'fluorescein-B-Chemical', 'injection-O', 'for-O', 'fundus-O', 'angiography-O', 'in-O', 'a-O', '47-O', ',-O', 'year-O', ',-O', 'old-O', 'male-O', '.-O']
['Despite-O', 'precautions-O', 'this-O', 'adverse-O', 'reaction-O', 'recurred-O', 'on-O', 're-O', ',-O', 'exposure-O', 'to-O', 'intravenous-O', 'fluorescein-B-Chemical']
['Pharmacology-O', 'of-O', 'ACC-9653-B-Chemical', '(-O', 'phenytoin-B-Chemical', 'prodrug-O', ').-O', 'ACC-9653-B-Chemical', ',-O', 'the-O', 'disodium-O', 'phosphate-O', 'ester-O', 'of-O', '3-hydroxymethyl-5,5-diphenylhydantoin-O', ',-O', 'is-O', 'a-O', 'prodrug-O', 'of-O', 'phenytoin-B-Chemical', 'with-O', 'advantageous-O', 'physicochemical-O', 'properties-O', '.-O']
['ACC-9653-B-Chemical', 'is-O', 'rapidly-O', 'converted-O', 'enzymatically-O', 'to-O', 'phenytoin-B-Chemical', 'in-O', 'vivo-O', '.-O']
['ACC-9653-B-Chemical', 'and-O', 'phenytoin-B-Chemical', 'sodium-B-Chemical', 'have-O', 'equivalent-O', 'anticonvulsant-O', 'activity-O', 'against-O', 'seizures-B-Disease', 'induced-O', 'by-O', 'maximal-O', 'electroshock-O', '(-O', 'MES-O', ')-O', 'in-O', 'mice-O', 'following-O', 'i-O', '.-O']
['p-O', '.-O', 'oral-O', ',-O', 'or-O', 'i-O', '.-O']
['v-O', '.-O']
['administration-O', '.-O']
['The-O', 'ED50-O', 'doses-O', 'were-O', '16-O', 'mg-O', '/-O', 'kg-O', 'for-O', 'i-O', '.-O']
['v-O', '.-O']
['ACC-9653-B-Chemical', 'and-O', '8-O', 'mg-O', '/-O', 'kg-O', 'for-O', 'i-O', '.-O']
['v-O', '.-O']
['phenytoin-B-Chemical', 'sodium-B-Chemical', '.-O']
['ACC-9653-B-Chemical', 'and-O', 'phenytoin-B-Chemical', 'sodium-B-Chemical', 'have-O', 'similar-O', 'antiarrhythmic-O', 'activity-O', 'against-O', 'ouabain-B-Chemical', ',-O', 'induced-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'in-O', 'anesthetized-O', 'dogs-O', '.-O']
['The-O', 'total-O', 'doses-O', 'of-O', 'ACC-9653-B-Chemical', 'or-O', 'phenytoin-B-Chemical', 'sodium-O', 'necessary-O', 'to-O', 'convert-O', 'the-O', 'arrhythmia-B-Disease', 'to-O', 'a-O', 'normal-O', 'sinus-B-Disease', 'rhythm-O', 'were-O', '24-O', '+-O', '6-O', 'and-O', '14-O', '+-O', '3-O', 'mg-O', '/-O', 'kg-O', ',-O', 'respectively-O', '.-O']
['Only-O', 'phenytoin-B-Chemical', 'sodium-I-Chemical', 'displayed-O', 'in-O', 'vitro-O', 'antiarrhythmic-O', 'activity-O', 'against-O', 'strophanthidin-B-Chemical', ',-O', 'induced-O', 'arrhythmias-B-Disease', 'in-O', 'guinea-O', 'pig-O', 'right-O', 'atria-O', '.-O']
['In-O', 'anesthetized-O', 'dogs-O', ',-O', 'a-O', 'high-O', 'dose-O', 'of-O', 'ACC-9653-B-Chemical', '(-O', '31-O', 'mg-O', '/-O', 'kg-O', ')-O', 'was-O', 'infused-O', 'over-O', '15-O', ',-O', '20-O', ',-O', 'and-O', '30-O', 'min-O', 'and-O', 'the-O', 'responses-O', 'were-O', 'compared-O', 'to-O', 'an-O', 'equimolar-O', 'dose-O', 'of-O', 'phenytoin-B-Chemical', 'sodium-B-Chemical', '(-O', '21-O', 'mg-O', '/-O', 'kg-O', ')-O', '.-O', 'The-O', 'ACC-9653-B-Chemical', 'and-O', 'phenytoin-B-Chemical', 'sodium-B-Chemical', 'treatments-O', 'produced-O', 'similar-O', 'marked-O', 'reductions-O', 'in-O', 'diastolic-O', 'blood-O', 'pressure-O', 'and-O', 'contractile-O', 'force-O', '(-O', 'LVdP-O', '/-O', 'dt-O', ')-O', '.-O', 'The-O', 'maximum-O', 'effects-O', 'of-O', 'each-O', 'treatment-O', 'occurred-O', 'at-O', 'the-O', 'time-O', 'of-O', 'maximum-O', 'phenytoin-B-Chemical', 'sodium-B-Chemical', 'levels-O', '.-O']
['Acute-B-Disease', 'toxicity-O', 'studies-O', 'of-O', 'ACC-9653-B-Chemical', 'and-O', 'phenytoin-B-Chemical', 'sodium-I-Chemical', 'were-O', 'carried-O', 'out-O', 'in-O', 'mice-O', ',-O', 'rats-O', ',-O', 'rabbits-O', ',-O', 'and-O', 'dogs-O', 'by-O', 'i-O', '.-O']
['v-O', '.-O', 'i-O', '.-O']
['m-O', '.-O', 'and-O', 'i-O', '.-O']
['p-O', '.-O']
['routes-O', 'of-O', 'administration-O', '.-O']
['The-O', 'systemic-O', 'toxic-O', 'signs-O', 'of-O', 'both-O', 'agents-O', 'were-O', 'similar-O', 'and-O', 'occurred-O', 'at-O', 'approximately-O', 'equivalent-O', 'doses-O', '.-O']
['Importantly-O', ',-O', 'the-O', 'local-O', 'irritation-O', 'of-O', 'ACC-9653-B-Chemical', 'was-O', 'markedly-O', 'less-O', 'than-O', 'phenytoin-B-Chemical', 'sodium-B-Chemical']
['Phenytoin-B-Chemical', 'induced-O', 'fatal-O', 'hepatic-B-Disease', 'injury-I-Disease', '.-O']
['A-O', '61-O', 'year-O', 'old-O', 'female-O', 'developed-O', 'fatal-O', 'hepatic-B-Disease', 'failure-I-Disease', 'after-O', 'phenytoin-B-Chemical', 'administration-O', '.-O']
['A-O', 'typical-O', 'multisystem-O', 'clinical-O', 'pattern-O', 'precedes-O', 'the-O', 'manifestations-O', 'of-O', 'hepatic-B-Disease', 'injury-I-Disease', '.-O']
['The-O', 'hematologic-O', ',-O', 'biochemical-O', 'and-O', 'pathologic-O', 'features-O', 'indicate-O', 'a-O', 'mixed-O', 'hepatocellular-B-Disease', 'damage-O', 'due-O', 'to-O', 'drug-O', 'hypersensitivity-B-Disease', '.-O']
['In-O', 'a-O', 'patient-O', 'receiving-O', 'phenytoin-B-Chemical']
['Treatment-O', 'of-O', 'lethal-O', 'pertussis-B-Disease', 'vaccine-O', 'reaction-O', 'with-O', 'histamine-B-Chemical', 'H1-O', 'antagonists-O', '.-O']
['We-O', 'studied-O', 'mortality-O', 'after-O', 'pertussis-B-Disease', 'immunization-O', 'in-O', 'the-O', 'mouse-O', '.-O']
['Without-O', 'treatment-O', ',-O', '73-O', 'of-O', '92-O', 'animals-O', '(-O', '80-O', ')-O', 'died-O', 'after-O', 'injection-O', 'of-O', 'bovine-O', 'serum-O', 'albumin-O', '(-O', 'BSA-O', ')-O', 'on-O', 'day-O', '+-O', '7-O', 'of-O', 'pertussis-O', 'immunization-O', '.-O']
['After-O', 'pretreatment-O', 'with-O', '3-O', 'mg-O', 'of-O', 'cyproheptadine-B-Chemical', ',-O', '2-O', 'mg-O', 'mianserin-B-Chemical', ',-O', 'or-O', '2-O', 'mg-O', 'chlorpheniramine-B-Chemical', ',-O', 'only-O', '5-O', 'of-O', '105-O', 'animals-O', '(-O', '5-O', ')-O', 'died-O', 'after-O', 'receiving-O', 'BSA-O', 'on-O', 'day-O', '+-O', '7-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', ').-O', 'Blockade-O', 'of-O', 'histamine-B-Chemical', 'H1-O', 'receptors-O', 'may-O', 'reduce-O', 'mortality-O', 'in-O', 'pertussis-O', 'immunization-O', ',-O', 'induced-O', 'encephalopathy-B-Disease']
['Support-O', 'for-O', 'adrenaline-B-Chemical', ',-O', 'hypertension-B-Disease', 'hypothesis-O', ':-O', '18-O', 'hour-O', 'pressor-O', 'effect-O', 'after-O', '6-O', 'hours-O', 'adrenaline-B-Chemical', 'infusion-O', '.-O']
['In-O', 'a-O', 'double-O', 'blind-O', ',-O', 'crossover-O', 'study-O', '6-O', 'h-O', 'infusions-O', 'of-O', 'adrenaline-B-Chemical', '(-O', '15-O', 'ng-O', '/-O', 'kg-O', '/-O', 'min-O', ';-O', '1-O', 'ng-O', '=', '5-O', '.-O']
['458-O', 'pmol-O', ')-O', 'noradrenaline-B-Chemical', '(-O', '30-O', 'ng-O', '/-O', 'kg-O', '/-O', 'min-O', ';-O', '1-O', 'ng-O', '=-O', '5-O', '.-O']
['911-O', 'pmol-O', ')-O', 'and-O', 'a-O', '5-O', '%-O', 'dextrose-B-Chemical', 'solution-O', '(-O', '5-O', '.-O']
['4-O', 'ml-O', '/-O', 'h-O', ')-O', 'were-O', 'given-O', 'to-O', 'ten-O', 'healthy-O', 'volunteers-O', 'in-O', 'random-O', 'order-O', '2-O', 'weeks-O', 'apart-O', '.-O']
['By-O', 'means-O', 'of-O', 'intra-O', ',-O', 'arterial-O', 'ambulatory-O', 'monitoring-O', 'the-O', 'haemodynamic-O', 'effects-O', 'were-O', 'followed-O', 'for-O', '18-O', 'h-O', 'after-O', 'the-O', 'infusions-O', 'were-O', 'stopped-O', '.-O']
['Adrenaline-B-Chemical', ',-O', 'but-O', 'not-O', 'noradrenaline-B-Chemical', ',-O', 'caused-O', 'a-O', 'delayed-O', 'and-O', 'protracted-O', 'pressor-O', 'effect-O', '.-O']
['Over-O', 'the-O', 'total-O', 'postinfusion-O', 'period-O', 'systolic-O', 'and-O', 'diastolic-O', 'arterial-O', 'pressure-O', 'were-O', '6-O', '(-O', 'SEM-O', '2-O', ')-O', '%-O', 'and-O', '7-O', '(-O', '2-O', ')-O', 'respectively-O', ',-O', 'higher-O', 'than-O', 'after-O', 'dextrose-O', 'infusion-O', '(-O', 'ANOVA-O', ',-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', ').-O', 'Thus-O', ',-O', 'stress-O', 'x-O', 'levels-O', 'of-O', 'adrenaline-B-Chemical', '(-O', '230-O', 'pg-O', '/-O', 'ml-O', ')-O', 'for-O', '6-O', 'h-O', 'cause-O', 'a-O', 'delayed-O', 'and-O', 'protracted-O', 'pressor-O', 'effect-O', '.-O']
['These-O', 'findings-O', 'are-O', 'strong-O', 'support-O', 'for-O', 'the-O', 'adrenaline-B-Chemical', ',-O', 'hypertension-B-Disease']
['Effect-O', 'of-O', 'alkylxanthines-B-Chemical', 'on-O', 'gentamicin-B-Chemical', ',-O', 'induced-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'in-O', 'the-O', 'rat-O', '.-O']
['Adenosine-Chemical', 'antagonists-O', 'have-O', 'been-O', 'previously-O', 'shown-O', 'to-O', 'be-O', 'of-O', 'benefit-O', 'in-O', 'some-O', 'ischaemic-Disease', 'and-O', 'nephrotoxic-Disease', 'models-O', 'of-O', 'acute-Disease', 'renal-Disease', 'failure-Disease', '(-O', 'ARF-Disease', ').-O', 'In-O', 'the-O', 'present-O', 'study-O', ',-O', 'the-O', 'effects-O', 'of-O', 'three-O', 'alkylxanthines-Chemical', 'with-O', 'different-O', 'potencies-O', 'as-O', 'adenosine-Chemical', 'antagonists-O', '8-phenyltheophylline-Chemical', ',-O', 'theophylline-Chemical', 'and-O', 'enprofylline-Chemical', ',-O', 'were-O', 'examined-O', 'in-O', 'rats-O', 'developing-O', 'acute-Disease', 'renal-Disease', 'failure-Disease', 'after-O', '4-O', 'daily-O', 'injections-O', 'of-O', 'gentamicin-Chemical', '(-O', '200-O', 'mg-O', 'kg-O', ',-O', '1-O', ').-O', 'Renal-O', 'function-O', 'was-O', 'assessed-O', 'by-O', 'biochemical-O', '(-O', 'plasma-O', 'urea-Chemical', 'and-O', 'creatinine-Chemical', ',-O', ')', 'functional-O', '(-O', 'urine-O', 'analysis-O', 'and-O', '[', '3H', ']-O', 'inulin-Chemical', 'and-O', '[', '14C', ']-O', 'p-aminohippuric-Chemical', 'acid-Chemical', 'clearances-O', ')-O', 'and-O', 'morphological-O', '(-O', 'degree-O', 'of-O', 'necrosis-O', ')-O', 'indices-O', '.-O']
['The-O', 'various-O', 'drug-O', 'treatments-O', 'produced-O', 'improvements-O', 'in-O', 'some-O', ',-O', 'but-O', 'not-O', 'all-O', ',-O', 'measurements-O', 'of-O', 'renal-O', 'function-O', '.-O']
['However-O', ',-O', 'any-O', 'improvement-O', 'produced-O', 'by-O', 'drug-O', 'treatment-O', 'was-O', 'largely-O', 'a-O', 'result-O', 'of-O', 'a-O', 'beneficial-O', 'effect-O', 'exerted-O', 'by-O', 'its-O', 'vehicle-O', '(-O', 'polyethylene-B-Chemical', 'glycol-I-Chemical', 'and-O', 'NaOH-B-Chemical', ')-O', '.-O', 'The-O', 'lack-O', 'of-O', 'any-O', 'consistent-O', 'protective-O', 'effect-O', 'noted-O', 'with-O', 'the-O', 'alkylxanthines-B-Chemical', 'tested-O', 'in-O', 'the-O', 'present-O', 'study-O', 'indicates-O', 'that-O', 'adenosine-B-Chemical', 'plays-O', 'little-O', ',-O', 'if-O', 'any-O', ',-O', 'pathophysiological-O', 'role-O', 'in-O', 'gentamicin-B-Chemical', ',-O', 'induced-O', 'ARF-B-Disease']
['Adverse-O', 'ocular-O', 'reactions-O', 'possibly-O', 'associated-O', 'with-O', 'isotretinoin-B-Chemical', '.-O']
['A-O', 'total-O', 'of-O', '261-O', 'adverse-O', 'ocular-O', 'reactions-O', 'occurred-O', 'in-O', '237-O', 'patients-O', 'who-O', 'received-O', 'isotretinoin-B-Chemical', ',-O', 'a-O', 'commonly-O', 'used-O', 'drug-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'severe-O', 'cystic-O', 'acne-B-Disease', '.-O']
['Blepharoconjunctivitis-B-Disease', ',', 'subjective-O', 'complaints-O', 'of-O', 'dry-B-Disease', 'eyes-I-Disease', ',', 'blurred-B-Disease', 'vision-I-Disease', ',', 'contact-O', 'lens-O', 'intolerance-O', ',', 'and-O', 'photodermatitis-B-Disease', 'are-O', 'reversible-O', 'side-O', 'effects-O', '.-O']
['More-O', 'serious-O', 'ocular-B-Disease', 'adverse-O', 'reactions-O', 'include-O', 'papilledema-B-Disease', ',', 'pseudotumor-B-Disease', 'cerebri-I-Disease', ',', 'and-O', 'white-O', 'or-O', 'gray-O', 'subepithelial-O', 'corneal-O', 'opacities-O', ';-O', 'all-O', 'of-O', 'these-O', 'are-O', 'reversible-O', 'if-O', 'the-O', 'drug-O', 'is-O', 'discontinued-O', '.-O']
['Reported-O', 'cases-O', 'of-O', 'decreased-O', 'dark-O', 'adaptation-B-Disease', 'are-O', 'under-O', 'investigation-O', '.-O']
['Isotretinoin-B-Chemical', 'is-O', 'contraindicated-O', 'in-O', 'pregnancy-O', 'because-O', 'of-O', 'the-O', 'many-O', 'reported-O', 'congenital-O', 'abnormalities-O', 'after-O', 'maternal-O', 'use-O', '(-O', 'including-O', 'microphthalmos-B-Disease', ',', 'orbital-B-Disease', 'hypertelorism-B-Disease', ',', 'and-O', 'optic-B-Disease', 'nerve-O', 'hypoplasia-B-Disease']
['Procaterol-B-Chemical', 'and-O', 'terbutaline-B-Chemical', 'in-O', 'bronchial-O', 'asthma-B-Disease', '.-O']
['A-O', 'double-O', ',-O', 'blind-O', ',-O', 'placebo-O', ',-O', 'controlled-O', ',-O', 'cross-O', ',-O', 'over-O', 'study-O', '.-O']
['Procaterol-B-Chemical', ',-O', 'a-O', 'new-O', 'beta-O', ',-O', '2-O', 'adrenoceptor-O', 'stimulant-O', ',-O', 'was-O', 'studied-O', 'in-O', 'a-O', 'double-O', ',-O', 'blind-O', ',-O', 'placebo-O', ',-O', 'controlled-O', ',-O', 'cross-O', ',-O', 'over-O', 'trial-O', 'in-O', 'patients-O', 'with-O', 'bronchial-O', 'asthma-B-Disease', '.-O']
['Oral-O', 'procaterol-B-Chemical', '50-O', 'micrograms-O', 'b-O', '.-O']
['d-O', '.-O', 'procaterol-B-Chemical', '100-O', 'micrograms-O', 'b-O', '.-O']
['d-O', '.-O', 'and-O', 'terbutaline-B-Chemical', '5-O', 'mg-O', 't-O', '.-O']
['i-O', '.-O']
['d-O', '.-O', 'were-O', 'compared-O', 'when-O', 'given-O', 'randomly-O', 'in-O', '1-O', ',-O', 'week-O', 'treatment-O', 'periods-O', '.-O']
['The-O', 'best-O', 'clinical-O', 'effect-O', 'was-O', 'found-O', 'with-O', 'terbutaline-B-Chemical', '.-O']
['Both-O', 'anti-O', ',-O', 'asthmatic-B-Disease', 'and-O', 'tremorgenic-B-Disease', 'effects-O', 'of-O', 'procaterol-B-Chemical', 'were-O', 'dose-O', ',-O', 'related-O', '.-O']
['Procaterol-B-Chemical']
['Subacute-O', 'effects-O', 'of-O', 'propranolol-B-Chemical', 'and-O', 'B-O', '24-O', '/', '76-O', 'on-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'rat-O', 'heart-O', 'hypertrophy-B-Disease', 'in-O', 'correlation-O', 'with-O', 'blood-O', 'pressure-O', '.-O']
['We-O', 'compared-O', 'the-O', 'potential-O', 'beta-O', ',-O', 'receptor-O', 'blocker-O', ',-O', 'B-O', '24-O', '/-O', '76-O', 'i-O', '.-O']
['e-O', '.-O']
['1-O', '-(-O', '2-O', ',', '4-O', ',', 'dichlorophenoxy-O', ')-O', '3-O', '[', '2-O', ',', '3-O', ',', '4-O', ',', 'dimethoxyphenyl-O', ')-O', 'ethanolamino-O', ']-O', 'prop-O', 'an-O', ',-O', '2-O', ',', 'ol-O', ',-O', 'which-O', 'is-O', 'characterized-O', 'by-O', 'beta-O', '1-O', ',', 'adrenoceptor-O', 'blocking-O', 'and-O', 'beta-O', '2-O', ',', 'adrenoceptor-O', 'stimulating-O', 'properties-O', 'with-O', 'propranolol-B-Chemical', '.-O']
['The-O', 'studies-O', 'were-O', 'performed-O', 'using-O', 'an-O', 'experimental-O', 'model-O', 'of-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'heart-B-Disease', 'hypertrophy-I-Disease', 'in-O', 'rats-O', '.-O']
['A-O', 'correlation-O', 'of-O', 'the-O', 'blood-O', 'pressure-O', 'was-O', 'neither-O', 'found-O', 'in-O', 'the-O', 'development-O', 'nor-O', 'in-O', 'the-O', 'attempt-O', 'to-O', 'suppress-O', 'the-O', 'development-O', 'of-O', 'heart-O', 'hypertrophy-B-Disease', 'with-O', 'the-O', 'two-O', 'beta-O', ',', 'receptor-O', 'blockers-O', '.-O']
['Both-O', 'beta-O', ',-O', 'blockers-O', 'influenced-O', 'the-O', 'development-O', 'of-O', 'hypertrophy-B-Disease', 'to-O', 'a-O', 'different-O', ',-O', 'but-O', 'not-O', 'reproducible-O', 'extent-O', '.-O']
['It-O', 'was-O', 'possible-O', 'to-O', 'suppress-O', 'the-O', 'increased-O', 'ornithine-B-Chemical', 'decarboxylase-O', 'activity-O', 'with-O', 'both-O', 'beta-O', ',-O', 'blockers-O', 'in-O', 'hypertrophied-O', 'hearts-O', ',-O', 'but-O', 'there-O', 'was-O', 'no-O', 'effect-O', 'on-O', 'the-O', 'heart-O', 'mass-O', '.-O']
['Neither-O', 'propranolol-B-Chemical', 'nor-O', 'B-O', '24-O', '/-O', '76-O', 'could-O', 'stop-O', 'the-O', 'changes-O', 'in-O', 'the-O', 'characteristic-O', 'myosin-B-Chemical', 'isoenzyme-O', 'pattern-O', 'of-O', 'the-O', 'hypertrophied-B-Disease', 'rat-O', 'heart-O', '.-O']
['Thus-O', ',-O', 'the-O', 'investigations-O', 'did-O', 'not-O', 'provide-O', 'any-O', 'evidence-O', 'that-O', 'the-O', 'beta-O', ',-O', 'receptor-O', 'blockers-O', 'propranolol-B-Chemical', 'and-O', 'B-O', '24-O', '/-O', '76-O', 'have-O', 'the-O', 'potency-O', 'to-O', 'prevent-O', 'isoproterenol-B-Chemical', 'from-O', 'producing-O', 'heart-O', 'hypertrophy-B-Disease']
['Comparison-O', 'of-O', 'the-O', 'effect-O', 'of-O', 'oxitropium-B-Chemical', 'bromide-I-Chemical', 'and-O', 'of-O', 'slow-O', '--O', 'release-O', 'theophylline-B-Chemical', 'on-O', 'nocturnal-O', 'asthma-B-Disease', '.-O']
['The-O', 'effects-O', 'of-O', 'a-O', 'new-O', 'inhaled-O', 'antimuscarinic-O', 'drug-O', ',-O', 'oxitropium-B-Chemical', 'bromide-I-Chemical', ',-O', 'and-O', 'of-O', 'a-O', 'slow-O', ',-O', 'release-O', 'theophylline-B-Chemical', 'preparation-O', 'upon-O', 'nocturnal-O', 'asthma-B-Disease', 'were-O', 'compared-O', 'in-O', 'a-O', 'placebo-O', ',-O', 'controlled-O', 'double-O', ',-O', 'blind-O', 'study-O', '.-O']
['Two-O', 'samples-O', 'were-O', 'studied-O', ':-O', '12-O', 'patients-O', 'received-O', 'oxitropium-B-Chemical', 'at-O', '600-O', 'micrograms-O', '(-O', '6-O', 'subjects-O', ')-O', 'or-O', 'at-O', '400-O', 'micrograms-O', 't-O', '.-O']
['i-O', '.-O']
['d-O', '(-O', '6-O', 'subjects-O', ')-O', 'whereas-O', '11-O', 'received-O', 'theophylline-B-Chemical', 'at-O', '300-O', 'mg-O', 'b-O', '.-O']
['i-O', '.-O']
['d-O', '.-O']
['Morning-O', 'dipping-O', ',-O', 'assessed-O', 'by-O', 'the-O', 'fall-O', 'in-O', 'peak-O', 'flow-O', 'overnight-O', ',-O', 'was-O', 'significantly-O', 'reduced-O', 'in-O', 'the-O', 'periods-O', 'when-O', 'either-O', 'active-O', 'drug-O', 'was-O', 'taken-O', ',-O', 'whereas-O', 'no-O', 'difference-O', 'was-O', 'noticed-O', 'during-O', 'the-O', 'placebo-O', 'administration-O', '.-O']
['No-O', 'significant-O', 'difference-O', 'was-O', 'noticed-O', 'between-O', 'results-O', 'obtained-O', 'with-O', 'either-O', 'active-O', 'drug-O', ',-O', 'as-O', 'well-O', 'as-O', 'with-O', 'either-O', 'dosage-O', 'of-O', 'oxitropium-B-Chemical', '.-O']
['No-O', 'subject-O', 'reported-O', 'side-O', 'effects-O', 'of-O', 'oxitropium-B-Chemical', ',-O', 'as-O', 'compared-O', 'to-O', 'three-O', 'subjects-O', 'reporting-O', 'nausea-B-Disease', ',-O', 'vomiting-B-Disease', 'and-O', 'tremors-B-Disease', 'after-O', 'theophylline-B-Chemical', '.-O']
['Oxitropium-B-Chemical', 'proves-O', 'to-O', 'be-O', 'a-O', 'valuable-O', 'alternative-O', 'to-O', 'theophylline-B-Chemical', 'in-O', 'nocturnal-O', 'asthma-B-Disease']
['Penicillin-B-Chemical', 'anaphylaxis-B-Disease', '.-O']
['A-O', 'case-O', 'of-O', 'oral-O', 'penicillin-B-Chemical', 'anaphylaxis-B-Disease', 'is-O', 'described-O', ',-O', 'and-O', 'the-O', 'terminology-O', ',-O', 'occurrence-O', ',-O', 'clinical-O', 'manifestations-O', ',-O', 'pathogenesis-O', ',-O', 'prevention-O', ',-O', 'and-O', 'treatment-O', 'of-O', 'anaphylaxis-B-Disease', 'are-O', 'reviewed-O', '.-O']
['Emergency-O', 'physicians-O', 'should-O', 'be-O', 'aware-O', 'of-O', 'oral-O', 'penicillin-B-Chemical', 'anaphylaxis-B-Disease']
['Reversible-O', 'valproic-B-Chemical', 'acid-I-Chemical', ',-O', 'induced-O', 'dementia-B-Disease', ':-O', 'a-O', 'case-O', 'report-O', '.-O']
['Reversible-O', 'valproic-B-Chemical', 'acid-I-Chemical', ',-O', 'induced-O', 'dementia-B-Disease', 'was-O', 'documented-O', 'in-O', 'a-O', '21-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'with-O', 'epilepsy-B-Disease', 'who-O', 'had-O', 'a-O', '3-O', ',-O', 'year-O', 'history-O', 'of-O', 'insidious-O', 'progressive-O', 'decline-O', 'in-O', 'global-O', 'cognitive-O', 'abilities-O', 'documented-O', 'by-O', 'serial-O', 'neuropsychological-O', 'studies-O', '.-O']
['Repeat-O', 'neuropsychological-O', 'testing-O', '7-O', 'weeks-O', 'after-O', 'discontinuation-O', 'of-O', 'the-O', 'drug-O', 'revealed-O', 'dramatic-O', 'improvement-O', 'in-O', 'IQ-O', ',-O', 'memory-O', ',-O', 'naming-O', ',-O', 'and-O', 'other-O', 'tasks-O', 'commensurate-O', 'with-O', 'clinical-O', 'recovery-O', 'in-O', 'his-O', 'intellectual-O', 'capacity-O', '.-O']
['Possible-O', 'pathophysiological-O', 'mechanisms-O', 'which-O', 'may-O', 'have-O', 'been-O', 'operative-O', 'in-O', 'this-O', 'case-O', 'include-O', ':-O', 'a-O', 'direct-O', 'central-O', 'nervous-O', 'system-O', '(-O', 'CNS-O', ')-O', 'toxic-O', 'effect-O', 'of-O', 'valproic-B-Chemical', 'acid-I-Chemical', ';-O', 'a-O', 'paradoxical-O', 'epileptogenic-O', 'effect-O', 'secondary-O', 'to-O', 'the-O', 'drug-O', ';-O', 'and-O', 'an-O', 'indirect-O', 'CNS-O', 'toxic-O', 'effect-O', 'mediated-O', 'through-O', 'valproic-B-Chemical', 'acid-I-Chemical', ',-O', 'induced-O', 'hyperammonemia-B-Disease']
['Reversal-O', 'of-O', 'scopolamine-B-Chemical', ',-O', 'induced-O', 'amnesia-B-Disease', 'of-O', 'passive-O', 'avoidance-O', 'by-O', 'pre-O', ',-O', 'and-O', 'post-O', ',-O', 'training-O', 'naloxone-B-Chemical', '.-O']
['In-O', 'a-O', 'series-O', 'of-O', 'five-O', 'experiments-O', ',-O', 'the-O', 'modulating-O', 'role-O', 'of-O', 'naloxone-B-Chemical', 'on-O', 'a-O', 'scopolamine-B-Chemical', ',-O', 'induced-O', 'retention-O', 'deficit-O', 'in-O', 'a-O', 'passive-O', 'avoidance-O', 'paradigm-O', 'was-O', 'investigated-O', 'in-O', 'mice-O', '.-O']
['Scopolamine-B-Chemical', ',-O', 'but-O', 'not-O', 'methyl-O', 'scopolamine-B-Chemical', '(-O', '1-O', 'and-O', '3-O', 'mg-O', '/-O', 'kg-O', ')-O', 'induced-O', 'an-O', 'amnesia-B-Disease', 'as-O', 'measured-O', 'by-O', 'latency-O', 'and-O', 'duration-O', 'parameters-O', '.-O']
['Naloxone-B-Chemical', '(-O', '0-O', '.-O']
['3-O', ',-O', '1-O', ',-O', '3-O', ',-O', 'and-O', '10-O', 'mg-O', '/-O', 'kg-O', ')-O', 'injected-O', 'prior-O', 'to-O', 'training-O', 'attenuated-O', 'the-O', 'retention-O', 'deficit-B-Disease', 'with-O', 'a-O', 'peak-O', 'of-O', 'activity-O', 'at-O', '3-O', 'mg-O', '/-O', 'kg-O', '.-O']
['The-O', 'effect-O', 'of-O', 'naloxone-B-Chemical', 'could-O', 'be-O', 'antagonized-O', 'with-O', 'morphine-B-Chemical', '(-O', '1-O', ',-O', '3-O', ',-O', 'and-O', '10-O', 'mg-O', '/-O', 'kg-O', ')-O', 'demonstrating-O', 'the-O', 'opioid-O', 'specificity-O', 'of-O', 'the-O', 'naloxone-B-Chemical', 'effect-O', '.-O']
['Post-O', ',-O', 'training-O', 'administration-O', 'of-O', 'naloxone-B-Chemical', '(-O', '3-O', 'mg-O', '/-O', 'kg-O', ')-O', 'as-O', 'a-O', 'single-O', 'or-O', 'as-O', 'a-O', 'split-O', 'dose-O', 'also-O', 'attenuated-O', 'the-O', 'scopolamine-B-Chemical', ',-O', 'induced-O', 'amnesia-B-Disease', '.-O']
['Control-O', 'experiments-O', 'indicated-O', 'that-O', 'neither-O', 'an-O', 'increase-O', 'in-O', 'pain-O', 'sensitivity-O', '(-O', 'pre-O', ',-O', 'training-O', 'naloxone-B-Chemical', ')', 'nor-O', 'an-O', 'induced-O', 'aversive-O', 'state-O', '(-O', 'post-O', ',-O', 'training-O', 'naloxone-B-Chemical', ')', 'appear-O', 'to-O', 'be-O', 'responsible-O', 'for-O', 'the-O', 'influence-O', 'of-O', 'naloxone-B-Chemical', 'on-O', 'the-O', 'scopolamine-B-Chemical', ',-O', 'induced-O', 'retention-O', 'deficit-O']
['Electron-O', 'microscopic-O', 'investigations-O', 'of-O', 'the-O', 'cyclophosphamide-B-Chemical', ',-O', 'induced-O', 'lesions-O', 'of-O', 'the-O', 'urinary-O', 'bladder-O', 'of-O', 'the-O', 'rat-O', 'and-O', 'their-O', 'prevention-O', 'by-O', 'mesna-B-Chemical', '.-O']
['Fully-O', 'developed-O', 'cyclophosphamide-B-Chemical', ',-O', 'induced-O', 'cystitis-B-Disease', 'is-O', 'characterized-O', 'by-O', 'nearly-O', 'complete-O', 'detachment-O', 'of-O', 'the-O', 'urothelium-O', ',-O', 'severe-O', 'submucosal-O', 'edema-O', 'owing-O', 'to-O', 'damage-O', 'to-O', 'the-O', 'microvascular-O', 'bed-O', 'and-O', 'focal-O', 'muscle-O', 'necroses-O', '.-O']
['The-O', 'initial-O', 'response-O', 'to-O', 'the-O', 'primary-O', 'attack-O', 'by-O', 'the-O', 'cyclophosphamide-B-Chemical', 'metabolites-O', 'seems-O', 'to-O', 'be-O', 'fragmentation-O', 'of-O', 'the-O', 'luminal-O', 'membrane-O', '.-O']
['This-O', 'damages-O', 'the-O', 'cellular-O', 'barrier-O', 'against-O', 'the-O', 'hypertonic-O', 'urine-O', '.-O']
['Subsequent-O', 'breaks-O', 'in-O', 'the-O', 'lateral-O', 'cell-O', 'membranes-O', 'of-O', 'the-O', 'superficial-O', 'cells-O', 'and-O', 'in-O', 'all-O', 'the-O', 'plasma-O', 'membranes-O', 'of-O', 'the-O', 'intermediate-O', 'and-O', 'basal-O', 'cells-O', ',-O', 'intercellular-O', 'and-O', 'intracellular-O', 'edema-O', 'and-O', 'disintegration-O', 'of-O', 'the-O', 'desmosomes-O', 'and-O', 'hemidesmosomes-O', 'lead-O', 'to-O', 'progressive-O', 'degeneration-O', 'and-O', 'detachment-O', 'of-O', 'the-O', 'epithelial-O', 'cells-O', 'with-O', 'exposure-O', 'and-O', 'splitting-O', 'of-O', 'the-O', 'basal-O', 'membrane-O', '.-O']
['The-O', 'morphological-O', 'changes-O', 'of-O', 'the-O', 'endothelial-O', 'cells-O', ',-O', 'which-O', 'become-O', 'more-O', 'pronounced-O', 'in-O', 'the-O', 'later-O', 'stages-O', 'of-O', 'the-O', 'experiment-O', ',-O', 'the-O', 'involvement-O', 'of-O', 'blood-O', 'vessels-O', 'regardless-O', 'of-O', 'their-O', 'diameter-O', 'and-O', 'the-O', 'location-O', ',-O', 'dependent-O', 'extent-O', 'of-O', 'the-O', 'damage-O', 'indicate-O', 'a-O', 'direct-O', 'type-O', 'of-O', 'damage-O', 'which-O', 'is-O', 'preceded-O', 'by-O', 'a-O', 'mediator-O', ',-O', 'induced-O', 'increase-O', 'in-O', 'permeability-O', ',-O', 'the-O', 'morphological-O', 'correlate-O', 'of-O', 'which-O', 'is-O', 'the-O', 'formation-O', 'of-O', 'gaps-O', 'in-O', 'the-O', 'interendothelial-O', 'cell-O', 'connections-O', 'on-O', 'the-O', 'venules-O', '.-O']
['These-O', 'changes-O', 'can-O', 'be-O', 'effectively-O', 'prevented-O', 'by-O', 'mesna-B-Chemical']
['Increase-O', 'in-O', 'intragastric-O', 'pressure-O', 'during-O', 'suxamethonium-B-Chemical', ',-O', 'induced-O', 'muscle-B-Disease', 'fasciculations-B-Disease', 'in-O', 'children-O', ':-O', 'inhibition-O', 'by-O', 'alfentanil-B-Chemical', '.-O']
['Changes-O', 'in-O', 'intragastric-O', 'pressure-O', 'after-O', 'the-O', 'administration-O', 'of-O', 'suxamethonium-B-Chemical', '1-O', '.-O']
['5-O', 'mg-O', 'kg-O', ',-O', '1-O', 'i-O', '.-O']
['v-O', '.-O']
['were-O', 'studied-O', 'in-O', '32-O', 'children-O', '(-O', 'mean-O', 'age-O', '6-O', '.-O']
['9-O', 'yr-O', ')-O', 'pretreated-O', 'with-O', 'either-O', 'physiological-O', 'saline-O', 'or-O', 'alfentanil-B-Chemical', '50-O', 'micrograms-O', 'kg-O', ',-O', '1-O', '.-O']
['Anaesthesia-O', 'was-O', 'induced-O', 'with-O', 'thiopentone-B-Chemical', '5-O', 'mg-O', 'kg-O', ',-O', '1-O', '.-O']
['The-O', 'incidence-O', 'and-O', 'intensity-O', 'of-O', 'muscle-O', 'fasciculations-B-Disease', 'caused-O', 'by-O', 'suxamethonium-B-Chemical', 'were-O', 'significantly-O', 'greater-O', 'in-O', 'the-O', 'control-O', 'than-O', 'in-O', 'the-O', 'alfentanil-B-Chemical', 'group-O', '.-O']
['The-O', 'intragastric-O', 'pressure-O', 'during-O', 'muscle-B-Disease', 'fasciculations-B-Disease', 'was-O', 'significantly-O', 'higher-O', 'in-O', 'the-O', 'control-O', 'group-O', '(-O', '16-O', '+-O', '0-O', '.-O']
['7-O', '(-O', 'SEM-O', ')-O', 'cm-O', 'H2O-B-Chemical', ')-O', 'than-O', 'in-O', 'the-O', 'alfentanil-B-Chemical', 'group-O', '(-O', '7-O', '.-O']
['7-O', '+-O', '1-O', '.-O']
['5-O', '(-O', 'SEM-O', ')-O', 'cm-O', 'H2O-B-Chemical', ')-O', '.-O', 'The-O', 'increase-O', 'in-O', 'intragastric-O', 'pressure-O', 'was-O', 'directly-O', 'related-O', 'to-O', 'the-O', 'intensity-O', 'of-O', 'muscle-O', 'fasciculations-B-Disease', '(-O', 'regression-O', 'line-O', ':-O', 'y-O', '=', '0-O', '.-O']
['5-O', '+-O', '4-O', '.-O']
['78x-O', 'with-O', 'r-O', 'of-O', '0-O', '.-O']
['78-O', ').-O', 'It-O', 'is-O', 'concluded-O', 'that-O', 'intragastric-O', 'pressure-O', 'increases-O', 'significantly-O', 'during-O', 'muscle-O', 'fasciculations-B-Disease', 'caused-O', 'by-O', 'suxamethonium-B-Chemical', 'in-O', 'healthy-O', 'children-O', '.-O']
['Alfentanil-B-Chemical', '50-O', 'micrograms-O', 'kg-O', ',-O', '1-O', 'effectively-O', 'inhibits-O', 'the-O', 'incidence-O', 'and-O', 'intensity-O', 'of-O', 'suxamethonium-B-Chemical', ',-O', 'induced-O', 'muscle-O', 'fasciculations-B-Disease']
['Acute-O', 'insulin-B-Chemical', 'treatment-O', 'normalizes-O', 'the-O', 'resistance-O', 'to-O', 'the-O', 'cardiotoxic-O', 'effect-O', 'of-O', 'isoproterenol-B-Chemical', 'in-O', 'streptozotocin-B-Chemical', 'diabetic-B-Disease', 'rats-O', '.-O']
['A-O', 'morphometric-O', 'study-O', 'of-O', 'isoproterenol-B-Chemical', 'induced-O', 'myocardial-B-Disease', 'fibrosis-I-Disease', '.-O']
['The-O', 'acute-O', 'effect-O', 'of-O', 'insulin-B-Chemical', 'treatment-O', 'on-O', 'the-O', 'earlier-O', 'reported-O', 'protective-O', 'effect-O', 'of-O', 'streptozotocin-B-Chemical', 'diabetes-B-Disease', 'against-O', 'the-O', 'cardiotoxic-O', 'effect-O', 'of-O', 'high-O', 'doses-O', 'of-O', 'isoproterenol-B-Chemical', '(-O', 'ISO-B-Chemical', ')-O', 'was-O', 'investigated-O', 'in-O', 'rats-O', '.-O']
['Thirty-O', 'to-O', '135-O', 'min-O', 'after-O', 'the-O', 'injection-O', 'of-O', 'crystalline-O', 'insulin-B-Chemical', ',-O', 'ISO-B-Chemical', 'was-O', 'given-O', 'subcutaneously-O', 'and-O', 'when-O', 'ISO-B-Chemical', 'induced-O', 'fibrosis-B-Disease', 'in-O', 'the-O', 'myocardium-O', 'was-O', 'morphometrically-O', 'analyzed-O', '7-O', 'days-O', 'later-O', ',-O', 'a-O', 'highly-O', 'significant-O', 'correlation-O', '(-O', 'r-O', '=-O', '0-O', '.-O']
['83-O', ',-O', '2-O', 'p-O', '=-O', '0-O', '.-O']
['006-O', ')-O', 'to-O', 'the-O', 'slope-O', 'of-O', 'the-O', 'fall-O', 'in-O', 'blood-O', 'glucose-B-Chemical', 'after-O', 'insulin-B-Chemical', 'treatment-O', 'appeared-O', '.-O']
['The-O', 'myocardial-O', 'content-O', 'of-O', 'catecholamines-B-Chemical', 'was-O', 'estimated-O', 'in-O', 'these-O', '8-O', 'day-O', 'diabetic-B-Disease', 'rats-O', '.-O']
['The-O', 'norepinephrine-B-Chemical', 'content-O', 'was-O', 'significantly-O', 'increased-O', 'while-O', 'epinephrine-B-Chemical', 'remained-O', 'unchanged-O', '.-O']
['An-O', 'enhanced-O', 'sympathetic-O', 'nervous-O', 'system-O', 'activity-O', 'with-O', 'a-O', 'consequent-O', 'down-O', '--O', 'regulation-O', 'of-O', 'the-O', 'myocardial-O', 'beta-O', ',-O', 'adrenergic-O', 'receptors-O', 'could-O', ',-O', 'therefore-O', ',-O', 'explain-O', 'this-O', 'catecholamine-B-Chemical', 'resistance-O', '.-O']
['The-O', 'rapid-O', 'reversion-O', 'after-O', 'insulin-B-Chemical', 'treatment-O', 'excludes-O', 'the-O', 'possibility-O', 'that-O', 'streptozotocin-B-Chemical', 'in-O', 'itself-O', 'causes-O', 'the-O', 'ISO-B-Chemical', 'resistance-O', 'and-O', 'points-O', 'towards-O', 'a-O', 'direct-O', 'insulin-B-Chemical', 'effect-O', 'on-O', 'myocardial-O', 'catecholamine-B-Chemical', 'sensitivity-O', 'in-O', 'diabetic-B-Disease', 'rats-O', '.-O']
['The-O', 'phenomenon-O', 'described-O', 'might-O', 'elucidate-O', 'pathogenetic-O', 'mechanisms-O', 'behind-O', 'toxic-O', 'myocardial-O', 'cell-O', 'degeneration-O', 'and-O', 'may-O', 'possibly-O', 'have-O', 'relevance-O', 'for-O', 'acute-O', 'cardiovascular-B-Disease', 'complications-I-Disease', 'in-O', 'diabetic-B-Disease']
['Differential-O', 'effects-O', 'of-O', 'non-O', ',-O', 'steroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'drugs-O', 'on-O', 'seizures-B-Disease', 'produced-O', 'by-O', 'pilocarpine-B-Chemical', 'in-O', 'rats-O', '.-O']
['The-O', 'muscarinic-O', 'cholinergic-O', 'agonist-O', 'pilocarpine-B-Chemical', 'induces-O', 'in-O', 'rats-O', 'seizures-B-Disease', 'and-O', 'status-B-Disease', 'epilepticus-I-Disease', 'followed-O', 'by-O', 'widespread-O', 'damage-O', 'to-O', 'the-O', 'forebrain-O', '.-O']
['The-O', 'present-O', 'study-O', 'was-O', 'designed-O', 'to-O', 'investigate-O', 'the-O', 'effect-O', 'of-O', '5-O', 'non-O', '--O', 'steroidal-O', 'anti-O', '--O', 'inflammatory-O', 'drugs-O', ',-O', 'sodium-O', 'salicylate-B-Chemical', ',-O', 'phenylbutazone-B-Chemical', ',-O', 'indomethacin-B-Chemical', ',-O', 'ibuprofen-B-Chemical', 'and-O', 'mefenamic-B-Chemical', 'acid-I-Chemical', ',-O', 'on-O', 'seizures-B-Disease', 'produced-O', 'by-O', 'pilocarpine-B-Chemical', '.-O']
['Pretreatment-O', 'of-O', 'rats-O', 'with-O', 'sodium-B-Chemical', 'salicylate-B-Chemical', ',-O', 'ED50-O', '103-O', 'mg-O', '/-O', 'kg-O', '(-O', '60-O', ',-O', '174-O', ')-O', 'and-O', 'phenylbutazone-B-Chemical', ',-O', '59-O', 'mg-O', '/-O', 'kg-O', '(-O', '50-O', ',-O', '70-O', ')-O', 'converted-O', 'the-O', 'non-O', ',-O', 'convulsant-O', 'dose-O', 'of-O', 'pilocarpine-B-Chemical', ',-O', '200-O', 'mg-O', '/-O', 'kg-O', ',-O', 'to-O', 'a-O', 'convulsant-O', 'one-O', '.-O']
['Indomethacin-B-Chemical', ',-O', '1-O', ',-O', '10-O', 'mg-O', '/-O', 'kg-O', ',-O', 'and-O', 'ibuprofen-B-Chemical', ',-O', '10-O', ',-O', '100-O', 'mg-O', '/-O', 'kg-O', ',-O', 'failed-O', 'to-O', 'modulate-O', 'seizures-B-Disease', 'produced-O', 'by-O', 'pilocarpine-B-Chemical', '.-O']
['Mefenamic-B-Chemical', 'acid-I-Chemical', ',-O', '26-O', '(-O', '22-O', ',-O', '30-O', ')-O', 'mg-O', '/-O', 'kg-O', ',-O', 'prevented-O', 'seizures-B-Disease', 'and-O', 'protected-O', 'rats-O', 'from-O', 'seizure-B-Disease', ',-O', 'related-O', 'brain-O', 'damage-O', 'induced-O', 'by-O', 'pilocarpine-B-Chemical', ',-O', '380-O', 'mg-O', '/-O', 'kg-O', '.-O']
['These-O', 'results-O', 'indicate-O', 'that-O', 'non-O', ',-O', 'steroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'drugs-O', 'differentially-O', 'modulate-O', 'the-O', 'threshold-O', 'for-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease']
['Acute-O', 'neurologic-O', 'dysfunction-O', 'after-O', 'high-O', ',-O', 'dose-O', 'etoposide-B-Chemical', 'therapy-O', 'for-O', 'malignant-O', 'glioma-I-Disease', '.-O']
['Etoposide-B-Chemical', '(-O', 'VP-16-213-B-Chemical', ')-O', 'has-O', 'been-O', 'used-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'many-O', 'solid-O', 'tumors-B-Disease', 'and-O', 'hematologic-B-Disease', 'malignancies-I-Disease', '.-O']
['When-O', 'used-O', 'in-O', 'high-O', 'doses-O', 'and-O', 'in-O', 'conjunction-O', 'with-O', 'autologous-O', 'bone-O', 'marrow-O', 'transplantation-O', ',-O', 'this-O', 'agent-O', 'has-O', 'activity-O', 'against-O', 'several-O', 'treatment-O', 'resistant-O', 'cancers-B-Disease', 'including-O', 'malignant-O', 'glioma-B-Disease', '.-O']
['In-O', 'six-O', 'of-O', 'eight-O', 'patients-O', '(-O', '75-O', ')-O', 'who-O', 'we-O', 'treated-O', 'for-O', 'recurrent-O', 'or-O', 'resistant-O', 'glioma-B-Disease', ',-O', 'sudden-O', 'severe-O', 'neurologic-B-Disease', 'deterioration-I-Disease', 'occurred-O', '.-O']
['This-O', 'developed-O', 'a-O', 'median-O', 'of-O', '9-O', 'days-O', 'after-O', 'initiation-O', 'of-O', 'high-O', ',-O', 'dose-O', 'etoposide-B-Chemical', 'therapy-O', '.-O']
['Significant-O', 'clinical-O', 'manifestations-O', 'have-O', 'included-O', 'confusion-B-Disease', ',-O', 'papilledema-B-Disease', ',-O', 'somnolence-B-Disease', ',-O', 'exacerbation-O', 'of-O', 'motor-O', 'deficits-O', ',-O', 'and-O', 'sharp-O', 'increase-O', 'in-O', 'seizure-B-Disease', 'activity-O', '.-O']
['These-O', 'abnormalities-I-Disease', 'resolved-O', 'rapidly-O', 'after-O', 'initiation-O', 'of-O', 'high-O', ',-O', 'dose-O', 'intravenous-O', 'dexamethasone-B-Chemical', 'therapy-O', '.-O']
['In-O', 'all-O', 'patients-O', ',-O', 'computerized-O', 'tomographic-O', '(-O', 'CT-O', ')', 'brain-O', 'scans-O', 'demonstrated-O', 'stability-O', 'in-O', 'tumor-B-Disease', 'size-O', 'and-O', 'peritumor-B-Disease', 'edema-I-Disease', 'when-O', 'compared-O', 'with-O', 'pretransplant-O', 'scans-O', '.-O']
['This-O', 'complication-O', 'appears-O', 'to-O', 'represent-O', 'a-O', 'significant-O', 'new-O', 'toxicity-I-Disease', 'of-O', 'high-O', ',-O', 'dose-O', 'etoposide-B-Chemical', 'therapy-O', 'for-O', 'malignant-B-Disease', 'glioma-I-Disease']
['Progressive-O', 'bile-B-Disease', 'duct-I-Disease', 'injury-I-Disease', 'after-O', 'thiabendazole-B-Chemical', 'administration-O', '.-O']
['A-O', '27-O', ',-O', 'yr-O', ',-O', 'old-O', 'man-O', 'developed-O', 'jaundice-B-Disease', '2-O', 'wk-O', 'after-O', 'exposure-O', 'to-O', 'thiabendazole-B-Chemical', '.-O']
['Cholestasis-B-Disease', 'persisted-O', 'for-O', '3-O', 'yr-O', ',-O', 'at-O', 'which-O', 'time-O', 'a-O', 'liver-O', 'transplant-O', 'was-O', 'performed-O', '.-O']
['Two-O', 'liver-O', 'biopsy-O', 'specimens-O', 'and-O', 'the-O', 'hepatectomy-O', 'specimen-O', 'were-O', 'remarkable-O', 'for-O', 'almost-O', 'complete-O', 'disappearance-O', 'of-O', 'interlobular-O', 'bile-O', 'ducts-O', '.-O']
['Prominent-O', 'fibrosis-B-Disease', 'and-O', 'hepatocellular-O', 'regeneration-O', 'were-O', 'also-O', 'present-O', ';-O', 'however-O', ',-O', 'the-O', 'lobular-O', 'architecture-O', 'was-O', 'preserved-O', '.-O']
['This-O', 'case-O', 'represents-O', 'an-O', 'example-O', 'of-O', 'x-O', 'idiosyncratic-O', 'x-O', 'drug-induced-O', 'liver-B-Disease', 'damage-O', 'in-O', 'which-O', 'the-O', 'primary-O', 'target-O', 'of-O', 'injury-O', 'is-O', 'the-O', 'bile-B-Disease', 'duct-I-Disease', '.-O']
['An-O', 'autoimmune-B-Disease', 'pathogenesis-O', 'of-O', 'the-O', 'bile-O', 'duct-O', 'destruction-O']
['Differential-O', 'effects-O', 'of-O', '1,4-dihydropyridine-B-Chemical', 'calcium-B-Chemical', 'channel-O', 'blockers-O', ':-O', 'therapeutic-O', 'implications-O', '.-O']
['Increasing-O', 'recognition-O', 'of-O', 'the-O', 'importance-O', 'of-O', 'calcium-B-Chemical', 'in-O', 'the-O', 'pathogenesis-O', 'of-O', 'cardiovascular-B-Disease', 'disease-I-Disease', 'has-O', 'stimulated-O', 'research-O', 'into-O', 'the-O', 'use-O', 'of-O', 'calcium-B-Chemical', 'channel-O', 'blocking-O', 'agents-O', 'for-O', 'treatment-O', 'of-O', 'a-O', 'variety-O', 'of-O', 'cardiovascular-B-Disease', 'diseases-I-Disease', '.-O']
['The-O', 'favorable-O', 'efficacy-O', 'and-O', 'tolerability-O', 'profiles-O', 'of-O', 'these-O', 'agents-O', 'make-O', 'them-O', 'attractive-O', 'therapeutic-O', 'modalities-O', '.-O']
['Clinical-O', 'applications-O', 'of-O', 'calcium-B-Chemical', 'channel-O', 'blockers-O', 'parallel-O', 'their-O', 'tissue-O', 'selectivity-O', '.-O']
['In-O', 'contrast-O', 'to-O', 'verapamil-B-Chemical', 'and-O', 'diltiazem-B-Chemical', ',-O', 'which-O', 'are-O', 'roughly-O', 'equipotent-O', 'in-O', 'their-O', 'actions-O', 'on-O', 'the-O', 'heart-O', 'and-O', 'vascular-O', 'smooth-O', 'muscle-O', ',-O', 'the-O', 'dihydropyridine-O', 'calcium-B-Chemical', 'channel-O', 'blockers-O', 'are-O', 'a-O', 'group-O', 'of-O', 'potent-O', 'peripheral-O', 'vasodilator-O', 'agents-O', 'that-O', 'exert-O', 'minimal-O', 'electrophysiologic-O', 'effects-O', 'on-O', 'cardiac-O', 'nodal-O', 'or-O', 'conduction-O', 'tissue-O', '.-O']
['As-O', 'the-O', 'first-O', 'dihydropyridine-O', 'available-O', 'for-O', 'use-O', 'in-O', 'the-O', 'United-O', 'States-O', ',-O', 'nifedipine-B-Chemical', 'controls-O', 'angina-B-Disease', 'and-O', 'hypertension-B-Disease', 'with-O', 'minimal-O', 'depression-O', 'of-O', 'cardiac-O', 'function-O', '.-O']
['Additional-O', 'members-O', 'of-O', 'this-O', 'group-O', 'of-O', 'calcium-B-Chemical', 'channel-O', 'blockers-O', 'have-O', 'been-O', 'studied-O', 'for-O', 'a-O', 'variety-O', 'of-O', 'indications-O', 'for-O', 'which-O', 'they-O', 'may-O', 'offer-O', 'advantages-O', 'over-O', 'current-O', 'therapy-O', '.-O']
['Once-O', 'or-O', 'twice-O', 'daily-O', 'dosage-O', 'possible-O', 'with-O', 'nitrendipine-B-Chemical', 'and-O', 'nisoldipine-B-Chemical', 'offers-O', 'a-O', 'convenient-O', 'administration-O', 'schedule-O', ',-O', 'which-O', 'encourages-O', 'patient-O', 'compliance-O', 'in-O', 'long-O', ',-O', 'term-O', 'therapy-O', 'of-O', 'hypertension-B-Disease', '.-O']
['The-O', 'coronary-O', 'vasodilating-O', 'properties-O', 'of-O', 'nisoldipine-B-Chemical', 'have-O', 'led-O', 'to-O', 'the-O', 'investigation-O', 'of-O', 'this-O', 'agent-O', 'for-O', 'use-O', 'in-O', 'angina-B-Disease', '.-O']
['Selectivity-O', 'for-O', 'the-O', 'cerebrovascular-O', 'bed-O', 'makes-O', 'nimodipine-B-Chemical', 'potentially-O', 'useful-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'subarachnoid-B-Disease', 'hemorrhage-I-Disease', ',-O', 'migraine-B-Disease', 'headache-B-Disease', ',-O', 'dementia-B-Disease', ',-O', 'and-O', 'stroke-B-Disease', '.-O']
['In-O', 'general-O', ',-O', 'the-O', 'dihydropyridine-O', 'calcium-B-Chemical', 'channel-O', 'blockers-O', 'are-O', 'usually-O', 'well-O', 'tolerated-O', ',-O', 'with-O', 'headache-B-Disease', ',-O', 'facial-O', 'flushing-B-Disease', ',-O', 'palpitations-B-Disease', ',-O', 'edema-B-Disease', ',-O', 'nausea-B-Disease', ',-O', 'anorexia-B-Disease', ',-O', 'and-O', 'dizziness-B-Disease']
['The-O', 'enhancement-O', 'of-O', 'aminonucleoside-I-Chemical', 'nephrosis-B-Disease', 'by-O', 'the-O', 'co-O', ',-O', 'administration-O', 'of-O', 'protamine-B-Chemical', '.-O']
['An-O', 'experimental-O', 'model-O', 'of-O', 'focal-O', 'segmental-O', 'glomerular-O', 'sclerosis-B-Disease', '(-O', 'FSGS-B-Disease', ')-O', 'was-O', 'developed-O', 'in-O', 'rats-O', 'by-O', 'the-O', 'combined-O', 'administration-O', 'of-O', 'puromycin-aminonucleoside-B-Chemical', '(-O', 'AMNS-B-Chemical', ')-O', 'and-O', 'protamine-B-Chemical', 'sulfate-B-Chemical', '(-O', 'PS-B-Chemical', ')-O', '.', 'Male-O', 'Sprague-O', ',-O', 'Dawley-O', 'rats-O', ',-O', 'uninephrectomized-O', 'three-O', 'weeks-O', 'before-O', ',-O', 'received-O', 'daily-O', 'injections-O', 'of-O', 'subcutaneous-O', 'AMNS-B-Chemical', '(-O', '1-O', 'mg-O', '/-O', '100-O', 'g-O', 'body-O', 'wt-O', ')-O', 'and-O', 'intravenous-O', 'PS-B-Chemical', '(-O', '2-O', 'separated-O', 'doses-O', 'of-O', '2-O', '.-O']
['5-O', 'mg-O', '/-O', '100-O', 'g-O', 'body-O', 'wt-O', ')-O', 'for-O', 'four-O', 'days-O', '.-O']
['The-O', 'series-O', 'of-O', 'injections-O', 'were-O', 'repeated-O', 'another-O', 'three-O', 'times-O', 'at-O', '10-O', 'day-O', 'intervals-O', '.-O']
['The-O', 'animals-O', 'were-O', 'sacrificed-O', 'on-O', 'days-O', '24-O', ',-O', '52-O', ',-O', 'and-O', '80-O', '.-O']
['They-O', 'developed-O', 'nephrotic-B-Disease', 'syndrome-I-Disease', 'and-O', 'finally-O', 'renal-B-Disease', 'failure-I-Disease', '.-O']
['The-O', 'time-O', ',-O', 'course-O', 'curve-O', 'of-O', 'creatinine-B-Chemical', 'clearance-O', 'dropped-O', 'and-O', 'showed-O', 'significant-O', 'difference-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ')-O', 'from-O', 'that-O', 'of-O', 'each-O', 'control-O', 'group-O', ',-O', 'such-O', 'as-O', ',-O', 'AMNS-B-Chemical', 'alone-O', ',-O', 'PS-B-Chemical', 'alone-O', 'or-O', 'saline-O', 'injected-O', '.-O']
['Their-O', 'glomeruli-O', 'showed-O', 'changes-O', 'of-O', 'progressive-O', 'FSGS-B-Disease', '.-O']
['The-O', 'ultrastructural-O', 'studies-O', 'in-O', 'the-O', 'initial-O', 'stage-O', 'revealed-O', 'significant-O', 'lack-O', 'of-O', 'particles-O', 'of-O', 'perfused-O', 'ruthenium-B-Chemical', 'red-O', 'on-O', 'the-O', 'lamina-O', 'rara-O', 'externa-O', 'and-O', 'marked-O', 'changes-O', 'in-O', 'epithelial-O', 'cell-O', 'cytoplasm-O', '.-O']
['Therefore-O', ',-O', 'it-O', 'is-O', 'suggested-O', 'that-O', 'the-O', 'administration-O', 'of-O', 'PS-B-Chemical', 'enhances-O', 'the-O', 'toxicity-O', 'of-O', 'AMNS-B-Chemical', 'on-O', 'the-O', 'glomerulus-O', 'and-O', 'readily-O', 'produces-O', 'progressive-O', 'FSGS-B-Disease', 'in-O', 'rats-O', 'resulting-O', 'in-O', 'the-O', 'end-stage-B-Disease', 'renal-I-Disease', 'disease-I-Disease']
['Theophylline-B-Chemical', 'neurotoxicity-B-Disease', 'in-O', 'pregnant-O', 'rats-O', '.-O']
['The-O', 'purpose-O', 'of-O', 'this-O', 'investigation-O', 'was-O', 'to-O', 'determine-O', 'whether-O', 'the-O', 'neurotoxicity-O', 'of-O', 'theophylline-B-Chemical', 'is-O', 'altered-O', 'in-O', 'advanced-O', 'pregnancy-O', '.-O']
['Sprague-O', ',-O', 'Dawley-O', 'rats-O', 'that-O', 'were-O', '20-O', 'days-O', 'pregnant-O', 'and-O', 'nonpregnant-O', 'rats-O', 'of-O', 'the-O', 'same-O', 'age-O', 'and-O', 'strain-O', 'received-O', 'infusions-O', 'of-O', 'aminophylline-B-Chemical', 'until-O', 'onset-O', 'of-O', 'maximal-O', 'seizures-B-Disease', 'which-O', 'occurred-O', 'after-O', '28-O', 'and-O', '30-O', 'minutes-O', 'respectively-O', '.-O']
['Theophylline-B-Chemical', 'concentrations-O', 'at-O', 'this-O', 'endpoint-O', 'in-O', 'serum-O', '(-O', 'total-O', ')-O', 'and-O', 'CSF-O', 'were-O', 'similar-O', 'but-O', 'serum-O', '(-O', 'free-O', ')-O', 'and-O', 'brain-O', 'concentrations-O', 'were-O', 'slightly-O', 'different-O', 'in-O', 'pregnant-O', 'rats-O', '.-O']
['Theophylline-B-Chemical', 'serum-O', 'protein-O', 'binding-O', 'determined-O', 'by-O', 'equilibrium-O', 'dialysis-O', 'was-O', 'lower-O', 'in-O', 'pregnant-O', 'rats-O', '.-O']
['Fetal-O', 'serum-O', 'concentrations-O', 'at-O', 'onset-O', 'of-O', 'seizures-B-Disease', 'in-O', 'the-O', 'mother-O', 'were-O', 'similar-O', 'to-O', 'maternal-O', 'brain-O', 'and-O', 'CSF-O', 'concentrations-O', 'and-O', 'correlated-O', 'significantly-O', 'with-O', 'the-O', 'former-O', '.-O']
['It-O', 'is-O', 'concluded-O', 'that-O', 'advanced-O', 'pregnancy-O', 'has-O', 'a-O', 'negligible-O', 'effect-O', 'on-O', 'the-O', 'neurotoxic-B-Disease', 'response-O', 'to-O', 'theophylline-B-Chemical']
['Hyperkalemia-B-Disease', 'induced-O', 'by-O', 'indomethacin-B-Chemical', 'and-O', 'naproxen-B-Chemical', 'and-O', 'reversed-O', 'by-O', 'fludrocortisone-B-Chemical', '.-O']
['We-O', 'have-O', 'described-O', 'a-O', 'patient-O', 'with-O', 'severe-O', 'rheumatoid-B-Disease', 'arthritis-I-Disease', 'and-O', 'a-O', 'history-O', 'of-O', 'mefenamic-B-Chemical', 'acid-I-Chemical', 'nephropathy-O', 'in-O', 'whom-O', 'hyperkalemia-B-Disease', 'and-O', 'inappropriate-O', 'hypoaldosteronism-O', 'were-O', 'caused-O', 'by-O', 'both-O', 'indomethacin-B-Chemical', 'and-O', 'naproxen-B-Chemical', ',-O', 'without-O', 'major-O', 'decline-O', 'in-O', 'renal-O', 'function-O', '.-O']
['It-O', 'is-O', 'likely-O', 'that-O', 'preexisting-O', 'renal-B-Disease', 'disease-I-Disease', 'predisposed-O', 'this-O', 'patient-O', 'to-O', 'type-O', 'IV-O', 'renal-B-Disease', 'tubular-O', 'acidosis-B-Disease', 'with-O', 'prostaglandin-B-Chemical', 'synthetase-O', 'inhibitors-O', '.-O']
['Because-O', 'he-O', 'was-O', 'unable-O', 'to-O', 'discontinue-O', 'nonsteroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'drug-O', 'therapy-O', ',-O', 'fludrocortisone-B-Chemical', 'was-O', 'added-O', ',-O', 'correcting-O', 'the-O', 'hyperkalemia-B-Disease', 'and-O', 'allowing-O', 'indomethacin-B-Chemical']
['Hypotension-B-Disease', 'as-O', 'a-O', 'manifestation-O', 'of-O', 'cardiotoxicity-B-Disease', 'in-O', 'three-O', 'patients-O', 'receiving-O', 'cisplatin-B-Chemical', 'and-O', '5-fluorouracil-B-Chemical', '.-O']
['Cardiac-O', 'symptoms-O', ',-O', 'including-O', 'hypotension-B-Disease', ',-O', 'developed-O', 'in-O', 'three-O', 'patients-O', 'with-O', 'advanced-O', 'colorectal-B-Disease', 'carcinoma-I-Disease', 'while-O', 'being-O', 'treated-O', 'with-O', 'cisplatin-B-Chemical', '(-O', 'CDDP-B-Chemical', ')-O', 'and-O', '5-fluorouracil-B-Chemical', '(-O', '5-FU-B-Chemical', ')-O', '.', 'In-O', 'two-O', 'patients-O', ',-O', 'hypotension-B-Disease', 'was-O', 'associated-O', 'with-O', 'severe-O', 'left-O', 'ventricular-O', 'dysfunction-I-Disease', '.-O']
['All-O', 'three-O', 'patients-O', 'required-O', 'therapy-O', 'discontinuation-O', '.-O']
['Cardiac-O', 'enzymes-O', 'remained-O', 'normal-O', 'despite-O', 'transient-O', 'electrocardiographic-O', '(-O', 'EKG-O', ')-O', 'changes-O', '.-O']
['The-O', 'presentation-O', 'and-O', 'cardiac-O', 'evaluation-O', '(-O', 'hemodynamic-O', ',-O', 'echocardiographic-O', ',-O', 'and-O', 'scintigraphic-O', ')', 'of-O', 'these-O', 'patients-O', 'suggest-O', 'new-O', 'manifestations-O', 'of-O', '5-FU-B-Chemical', 'cardiotoxicity-B-Disease', 'that-O', 'may-O', 'be-O', 'influenced-O', 'by-O', 'CDDP-B-Chemical']
['Fatal-O', 'aplastic-B-Disease', 'anemia-I-Disease', 'in-O', 'a-O', 'patient-O', 'treated-O', 'with-O', 'carbamazepine-B-Chemical', '.-O']
['A-O', 'case-O', 'of-O', 'fatal-O', 'aplastic-B-Disease', 'anemia-I-Disease', 'due-O', 'to-O', 'carbamazepine-B-Chemical', 'treatment-O', 'in-O', 'an-O', 'epileptic-O', 'woman-O', 'is-O', 'reported-O', '.-O']
['Despite-O', 'concerns-O', 'of-O', 'fatal-O', 'bone-B-Disease', 'marrow-I-Disease', 'toxicity-O', 'due-O', 'to-O', 'carbamazepine-B-Chemical', ',-O', 'this-O', 'is-O', 'only-O', 'the-O', 'fourth-O', 'documented-O', 'and-O', 'published-O', 'report-O', '.-O']
['Carbamazepine-B-Chemical']
['Participation-O', 'of-O', 'a-O', 'bulbospinal-O', 'serotonergic-O', 'pathway-O', 'in-O', 'the-O', 'rat-O', 'brain-O', 'in-O', 'clonidine-B-Chemical', ',-O', 'induced-O', 'hypotension-B-Disease', 'and-O', 'bradycardia-B-Disease', '.-O']
['The-O', 'effects-O', 'of-O', 'microinjection-O', 'of-O', 'clonidine-B-Chemical', '(-O', '1-O', ',-O', '10-O', 'micrograms-O', 'in-O', '1-O', 'microliter-O', ')-O', 'into-O', 'a-O', 'region-O', 'adjacent-O', 'to-O', 'the-O', 'ventrolateral-O', 'surface-O', 'of-O', 'the-O', 'medulla-O', 'oblongata-O', 'on-O', 'cardiovascular-O', 'function-O', 'were-O', 'assessed-O', 'in-O', 'urethane-B-Chemical', ',-O', 'anesthetized-O', 'rats-O', '.-O']
['Intramedullary-O', 'administration-O', 'of-O', 'clonidine-B-Chemical', ',-O', 'but-O', 'not-O', 'saline-O', 'vehicle-O', ',-O', 'caused-O', 'a-O', 'dose-O', ',-O', 'dependent-O', 'decrease-O', 'in-O', 'both-O', 'the-O', 'mean-O', 'arterial-O', 'pressure-O', 'and-O', 'the-O', 'heart-O', 'rate-O', '.-O']
['The-O', 'clonidine-B-Chemical', ',-O', 'induced-O', 'hypotension-B-Disease', 'was-O', 'antagonized-O', 'by-O', 'prior-O', 'spinal-O', 'transection-O', ',-O', 'but-O', 'not-O', 'bilateral-O', 'vagotomy-O', '.-O']
['On-O', 'the-O', 'other-O', 'hand-O', ',-O', 'the-O', 'clonidine-B-Chemical', ',-O', 'induced-O', 'bradycardia-B-Disease', 'was-O', 'antagonized-O', 'by-O', 'prior-O', 'bilateral-O', 'vagotomy-O', ',-O', 'but-O', 'not-O', 'spinal-O', 'transection-O', '.-O']
['Furthermore-O', ',-O', 'selective-O', 'destruction-O', 'of-O', 'the-O', 'spinal-O', '5-HT-O', 'nerves-O', ',-O', 'produced-O', 'by-O', 'bilateral-O', 'spinal-O', 'injection-O', 'of-O', '5,7-dihydroxytryptamine-B-Chemical', ',-O', 'reduced-O', 'the-O', 'magnitude-O', 'of-O', 'the-O', 'vasodepressor-O', 'or-O', 'the-O', 'bradycardiac-O', 'responses-O', 'to-O', 'clonidine-B-Chemical', 'microinjected-O', 'into-O', 'the-O', 'area-O', 'near-O', 'the-O', 'ventrolateral-O', 'surface-O', 'of-O', 'the-O', 'medulla-O', 'oblongata-O', 'in-O', 'rats-O', '.-O']
['The-O', 'data-O', 'indicate-O', 'that-O', 'a-O', 'bulbospinal-O', 'serotonergic-O', 'pathway-O', 'is-O', 'involved-O', 'in-O', 'development-O', 'of-O', 'clonidine-B-Chemical', ',-O', 'induced-O', 'hypotension-B-Disease', 'and-O', 'bradycardia-B-Disease', '.-O']
['The-O', 'induced-O', 'hypotension-B-Disease', 'is-O', 'brought-O', 'about-O', 'by-O', 'a-O', 'decrease-O', 'in-O', 'sympathetic-O', 'efferent-O', 'activity-O', ',-O', 'whereas-O', 'the-O', 'induced-O', 'bradycardia-B-Disease']
['Hypertension-B-Disease', 'in-O', 'neuroblastoma-B-Disease', 'induced-O', 'by-O', 'imipramine-B-Chemical', '.-O']
['Hypertension-B-Disease', 'is-O', 'a-O', 'well-O', ',-O', 'known-O', 'finding-O', 'in-O', 'some-O', 'patients-O', 'with-O', 'neuroblastoma-B-Disease', '.-O']
['However-O', ',-O', 'it-O', 'has-O', 'not-O', 'previously-O', 'been-O', 'described-O', 'in-O', 'association-O', 'with-O', 'the-O', 'use-O', 'of-O', 'Imipramine-B-Chemical', '.-O']
['We-O', 'report-O', 'the-O', 'occurrence-O', 'of-O', 'severe-O', 'hypertension-B-Disease', '(-O', 'blood-O', 'pressure-O', '190-O', '/-O', '160-O', ')-O', 'in-O', 'a-O', '4-O', ',-O', 'year-O', ',-O', 'old-O', 'girl-O', 'with-O', 'neuroblastoma-B-Disease', 'who-O', 'was-O', 'given-O', 'Imipramine-B-Chemical', 'to-O', 'control-O', 'a-O', 'behavior-O', 'disorder-O', '.-O']
['It-O', 'was-O', 'determined-O', 'later-O', 'that-O', 'this-O', 'patient-O', 'x-O', 's-O', 'tumor-B-Disease', 'was-O', 'recurring-O', 'at-O', 'the-O', 'time-O', 'of-O', 'her-O', 'hypertensive-B-Disease', 'episode-O', '.-O']
['Since-O', 'she-O', 'had-O', 'no-O', 'blood-O', 'pressure-O', 'elevation-O', 'at-O', 'initial-O', 'diagnosis-O', 'and-O', 'none-O', 'following-O', 'discontinuation-O', 'of-O', 'the-O', 'Imipramine-B-Chemical', '(-O', 'when-O', 'she-O', 'was-O', 'in-O', 'florid-O', 'relapse-O', ')-O', 'we-O', 'believe-O', 'that-O', 'this-O', 'drug-O', 'rather-O', 'than-O', 'her-O', 'underlying-O', 'disease-O', 'alone-O', 'caused-O', 'her-O', 'hypertension-B-Disease', '.-O']
['The-O', 'mechanism-O', 'for-O', 'this-O', 'reaction-O', 'is-O', 'believed-O', 'to-O', 'be-O', 'increased-O', 'levels-O', 'of-O', 'vasoactive-O', 'catecholamines-B-Chemical', 'due-O', 'to-O', 'interference-O', 'of-O', 'their-O', 'physiologic-O', 'inactivation-O', 'by-O', 'Imipramine-B-Chemical', '.-O']
['From-O', 'this-O', 'experience-O', ',-O', 'we-O', 'urge-O', 'extreme-O', 'caution-O', 'in-O', 'the-O', 'use-O', 'of-O', 'tricyclic-O', 'antidepressants-B-Chemical', 'in-O', 'children-O', 'with-O', 'active-O', 'neuroblastoma-B-Disease']
['Rechallenge-O', 'of-O', 'patients-O', 'who-O', 'developed-O', 'oral-O', 'candidiasis-B-Disease', 'or-O', 'hoarseness-B-Disease', 'with-O', 'beclomethasone-B-Chemical', 'dipropionate-B-Chemical', '.-O']
['Of-O', '158-O', 'asthmatic-B-Disease', 'patients-O', 'who-O', 'were-O', 'placed-O', 'on-O', 'inhaled-O', 'beclomethasone-B-Chemical', ',-O', '15-O', '(-O', '9-O', '.-O']
['5-O', ')-O', 'developed-O', 'either-O', 'hoarseness-O', '(-O', '8-O', ')-O', ',', 'oral-O', 'thrush-O', '(-O', '6-O', ')-O', ',', 'or-O', 'both-O', '(-O', '1-O', ')-O', '.', 'When-O', 'their-O', 'adverse-O', 'reactions-O', 'subsided-O', ',-O', 'seven-O', 'of-O', 'these-O', '15-O', 'patients-O', 'were-O', 'rechallenged-O', 'with-O', 'inhaled-O', 'beclomethasone-B-Chemical', '.-O']
['These-O', 'included-O', 'five-O', 'cases-O', 'who-O', 'developed-O', 'hoarseness-B-Disease', 'and-O', 'three-O', 'who-O', 'developed-O', 'Candidiasis-B-Disease', '.-O']
['One-O', 'patient-O', 'had-O', 'both-O', '.-O']
['Oral-O', 'thrush-B-Disease', 'did-O', 'not-O', 'recur-O', ',-O', 'but-O', '60-O', '(-O', '3-O', '/-O', '5-O', ')', 'of-O', 'patients-O', 'with-O', 'hoarseness-B-Disease', 'had-O', 'recurrence-O', '.-O']
['We-O', 'conclude-O', 'that-O', 'patients-O', 'may-O', 'be-O', 'restarted-O', 'on-O', 'inhaled-O', 'beclomethasone-B-Chemical', 'when-O', 'clinically-O', 'indicated-O', ';-O', 'however-O', ',-O', 'because-O', 'of-O', 'the-O', 'high-O', 'recurrence-O', 'rate-O', ',-O', 'patients-O', 'who-O', 'develop-O', 'hoarseness-B-Disease', 'should-O', 'not-O', 'be-O', 're-O', ',-O', 'challenged-O', '.-O']
['Concomitant-O', 'use-O', 'of-O', 'oral-O', 'prednisone-B-Chemical', 'and-O', 'topical-O', 'beclomethasone-B-Chemical', 'may-O', 'increase-O', 'the-O', 'risk-O', 'of-O', 'developing-O', 'hoarseness-B-Disease', 'or-O', 'candidiasis-B-Disease']
['Cyclophosphamide-B-Chemical', 'cardiotoxicity-B-Disease', ':-O', 'an-O', 'analysis-O', 'of-O', 'dosing-O', 'as-O', 'a-O', 'risk-O', 'factor-O', '.-O']
['Patients-O', 'who-O', 'undergo-O', 'bone-O', 'marrow-O', 'transplantation-O', 'are-O', 'generally-O', 'immunosuppressed-O', 'with-O', 'a-O', 'dose-O', 'of-O', 'cyclophosphamide-B-Chemical', '(-O', 'CYA-B-Chemical', ')-O', 'which-O', 'is-O', 'usually-O', 'calculated-O', 'based-O', 'on-O', 'the-O', 'patient-O', 'x-O', 's-O', 'weight-O', '.-O']
['At-O', 'these-O', 'high-O', 'doses-O', 'of-O', 'CYA-B-Chemical', ',-O', 'serious-O', 'cardiotoxicity-B-Disease', 'may-O', 'occur-O', ',-O', 'but-O', 'definitive-O', 'risk-O', 'factors-O', 'for-O', 'the-O', 'development-O', 'of-O', 'such-O', 'cardiotoxicity-B-Disease', 'have-O', 'not-O', 'been-O', 'described-O', '.-O']
['Since-O', 'chemotherapeutic-O', 'agent-O', 'toxicity-B-Disease', 'generally-O', 'correlates-O', 'with-O', 'dose-O', 'per-O', 'body-O', 'surface-O', 'area-O', ',-O', 'we-O', 'retrospectively-O', 'calculated-O', 'the-O', 'dose-O', 'of-O', 'CYA-B-Chemical', 'in-O', 'patients-O', 'transplanted-O', 'at-O', 'our-O', 'institution-O', 'to-O', 'determine-O', 'whether-O', 'the-O', 'incidence-O', 'of-O', 'CYA-B-Chemical', 'cardiotoxicity-B-Disease', 'correlated-O', 'with-O', 'the-O', 'dose-O', 'per-O', 'body-O', 'surface-O', 'area-O', '.-O']
['Eighty-O', 'patients-O', 'who-O', 'were-O', 'to-O', 'receive-O', 'CYA-B-Chemical', '50-O', 'mg-O', '/-O', 'kg-O', '/-O', 'd-O', 'for-O', 'four-O', 'days-O', 'as-O', 'preparation-O', 'for-O', 'marrow-O', 'grafting-O', 'underwent-O', 'a-O', 'total-O', 'of-O', '84-O', 'transplants-O', 'for-O', 'aplastic-B-Disease', 'anemia-I-Disease', ',-O', 'Wiskott-Aldrich-B-Disease', 'syndrome-I-Disease', ',-O', 'or-O', 'severe-O', 'combined-O', 'immunodeficiency-B-Disease', 'syndrome-I-Disease', '.-O']
['Fourteen-O', 'of-O', '84-O', '(-O', '17-O', ')-O', 'patients-O', 'had-O', 'symptoms-O', 'and-O', 'signs-O', 'consistent-O', 'with-O', 'CYA-B-Chemical', 'cardiotoxicity-B-Disease', 'within-O', 'ten-O', 'days-O', 'of-O', 'receiving-O', '1-O', 'to-O', '4-O', 'doses-O', 'of-O', 'CYA-B-Chemical', '.-O']
['Six-O', 'of-O', 'the-O', '14-O', 'patients-O', 'died-O', 'with-O', 'congestive-B-Disease', 'heart-I-Disease', 'failure-I-Disease', '.-O']
['The-O', 'dose-O', 'of-O', 'CYA-B-Chemical', 'per-O', 'body-O', 'surface-O', 'area-O', 'was-O', 'calculated-O', 'for-O', 'all-O', 'patients-O', 'and-O', 'the-O', 'patients-O', 'were-O', 'divided-O', 'into-O', 'two-O', 'groups-O', 'based-O', 'on-O', 'daily-O', 'CYA-B-Chemical', 'dose-O', ':-O', 'Group-O', '1-O', ',-O', 'CYA-B-Chemical', 'less-O', 'than-O', 'or-O', 'equal-O', 'to-O', '1-O', '.-O']
['55-O', 'g-O', '/-O', 'm2-O', '/-O', 'd-O', ';-O', 'Group-O', '2-O', ',-O', 'CYA-B-Chemical', 'greater-O', 'than-O', '1-O', '.-O']
['55-O', 'g-O', '/-O', 'm2-O', '/-O', 'd-O', '.-O']
['Cardiotoxicity-B-Disease', 'that-O', 'was-O', 'thought-O', 'to-O', 'be-O', 'related-O', 'to-O', 'CYA-B-Chemical', 'occurred-O', 'in-O', '1-O', '/-O', '32-O', '(-O', '3-O', ')-O', 'of-O', 'patients-O', 'in-O', 'Group-O', '1-O', 'and-O', 'in-O', '13-O', '/-O', '52-O', '(-O', '25-O', ')-O', 'patients-O', 'in-O', 'Group-O', '2-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['025-O', ').-O', 'Congestive-B-Disease', 'heart-I-Disease', 'failure-I-Disease', 'caused-O', 'or-O', 'contributed-O', 'to-O', 'death-O', 'in-O', '0-O', '/-O', '32-O', 'patients-O', 'in-O', 'Group-O', '1-O', 'v-O', '6-O', '/-O', '52-O', '(-O', '12-O', ')-O', 'of-O', 'patients-O', 'in-O', 'Group-O', '2-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['25-O', ').-O', 'There-O', 'was-O', 'no-O', 'difference-O', 'in-O', 'the-O', 'rate-O', 'of-O', 'engraftment-O', 'of-O', 'evaluable-O', 'patients-O', 'in-O', 'the-O', 'two-O', 'groups-O', '(-O', 'P-O', 'greater-O', 'than-O', '0-O', '.-O']
['5-O', ').-O', 'We-O', 'conclude-O', 'that-O', 'the-O', 'CYA-B-Chemical', 'cardiotoxicity-O', 'correlates-O', 'with-O', 'CYA-B-Chemical', 'dosage-O', 'as-O', 'calculated-O', 'by-O', 'body-O', 'surface-O', 'area-O', ',-O', 'and-O', 'that-O', 'patients-O', 'with-O', 'aplastic-B-Disease', 'anemia-I-Disease', 'and-O', 'immunodeficiencies-O', 'can-O', 'be-O', 'effectively-O', 'prepared-O', 'for-O', 'bone-O', 'marrow-O', 'grafting-O', 'at-O', 'a-O', 'CYA-B-Chemical', 'dose-O', 'of-O', '1-O', '.-O']
['55-O', 'g-O', '/-O', 'm2-O', '/-O', 'd-O', 'for-O', 'four-O', 'days-O', 'with-O', 'a-O', 'lower-O', 'incidence-O', 'of-O', 'cardiotoxicity-B-Disease', 'than-O', 'patients-O', 'whose-O', 'CYA-B-Chemical', 'dosage-O', 'is-O', 'calculated-O', 'based-O', 'on-O', 'weight-O', '.-O']
['This-O', 'study-O', 'reaffirms-O', 'the-O', 'principle-O', 'that-O', 'drug-O', 'toxicity-B-Disease']
['Studies-O', 'of-O', 'risk-O', 'factors-O', 'for-O', 'aminoglycoside-B-Chemical', 'nephrotoxicity-B-Disease', '.-O']
['The-O', 'epidemiology-O', 'of-O', 'aminoglycoside-B-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease', 'is-O', 'not-O', 'fully-O', 'understood-O', '.-O']
['Experimental-O', 'studies-O', 'in-O', 'healthy-O', 'human-O', 'volunteers-O', 'indicate-O', 'aminoglycosides-B-Chemical', 'cause-O', 'proximal-O', 'tubular-O', 'damage-O', 'in-O', 'most-O', 'patients-O', ',-O', 'but-O', 'rarely-O', ',-O', 'if-O', 'ever-O', ',-O', 'cause-O', 'glomerular-O', 'or-O', 'tubular-O', 'dysfunction-O', '.-O']
['Clinical-O', 'trials-O', 'of-O', 'aminoglycosides-B-Chemical', 'in-O', 'seriously-O', 'ill-O', 'patients-O', 'indicate-O', 'that-O', 'the-O', 'relative-O', 'risk-O', 'for-O', 'developing-O', 'acute-B-Disease', 'renal-B-Disease', 'failure-I-Disease', 'during-O', 'therapy-O', 'ranges-O', 'from-O', '8-O', 'to-O', '10-O', 'and-O', 'that-O', 'the-O', 'attributable-O', 'risk-O', 'is-O', '70-O', '%-O', 'to-O', '80-O', '.-O', 'Further-O', 'analysis-O', 'of-O', 'these-O', 'data-O', 'suggests-O', 'that-O', 'the-O', 'duration-O', 'of-O', 'therapy-O', ',-O', 'plasma-O', 'aminoglycoside-B-Chemical', 'levels-O', ',-O', 'liver-O', 'disease-O', ',-O', 'advanced-O', 'age-O', ',-O', 'high-O', 'initial-O', 'estimated-O', 'creatinine-B-Chemical', 'clearance-O', 'and-O', ',-O', 'possibly-O', ',-O', 'female-O', 'gender-O', 'all-O', 'increase-O', 'the-O', 'risk-O', 'for-O', 'nephrotoxicity-O', '.-O']
['Other-O', 'causes-O', 'of-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', ',-O', 'such-O', 'as-O', 'shock-B-Disease', ',-O', 'appear-O', 'to-O', 'have-O', 'an-O', 'additive-O', 'effect-O', '.-O']
['Predictive-O', 'models-O', 'have-O', 'been-O', 'developed-O', 'from-O', 'these-O', 'analyses-O', 'that-O', 'should-O', 'be-O', 'useful-O', 'for-O', 'identifying-O', 'patients-O', 'at-O', 'high-O', 'risk-O', '.-O']
['These-O', 'models-O', 'may-O', 'also-O', 'be-O', 'useful-O', 'in-O', 'developing-O', 'insights-O', 'into-O', 'the-O', 'pathophysiology-O', 'of-O', 'aminoglycoside-B-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease']
['Flurothyl-O', 'seizure-B-Disease', 'thresholds-O', 'in-O', 'mice-O', 'treated-O', 'neonatally-O', 'with-O', 'a-O', 'single-O', 'injection-O', 'of-O', 'monosodium-B-Chemical', 'glutamate-B-Chemical', '(-O', 'MSG-B-Chemical', '):-O', 'evaluation-O', 'of-O', 'experimental-O', 'parameters-O', 'in-O', 'flurothyl-O', 'seizure-B-Disease', 'testing-O', '.-O']
['Monosodium-O', 'glutamate-B-Chemical', '(', 'MSG-B-Chemical', ')', 'administration-O', 'to-O', 'neonatal-O', 'rodents-O', 'produces-O', 'convulsions-B-Disease', 'and-O', 'results-O', 'in-O', 'numerous-O', 'biochemical-O', 'and-O', 'behavioral-B-Disease', 'deficits-O', '.-O']
['These-O', 'studies-O', 'were-O', 'undertaken-O', 'to-O', 'determine-O', 'if-O', 'neonatal-O', 'administration-O', 'of-O', 'MSG-B-Chemical', 'produced-O', 'permanent-O', 'alterations-O', 'in-O', 'seizure-B-Disease', 'susceptibility-O', ',-O', 'since-O', 'previous-O', 'investigations-O', 'were-O', 'inconclusive-O', '.-O']
['A-O', 'flurothyl-B-Chemical', 'ether-O', 'seizure-B-Disease', 'screening-O', 'technique-O', 'was-O', 'used-O', 'to-O', 'evaluate-O', 'seizure-B-Disease', 'susceptibility-O', 'in-O', 'adult-O', 'mice-O', 'that-O', 'received-O', 'neonatal-O', 'injections-O', 'of-O', 'MSG-B-Chemical', '(-O', '4-O', 'mg-O', '/-O', 'g-O', 'and-O', '1-O', 'mg-O', '/-O', 'g-O', ').-O', 'MSG-B-Chemical', 'treatment-O', 'resulted-O', 'in-O', 'significant-O', 'reductions-O', 'in-O', 'whole-O', 'brain-O', 'weight-O', 'but-O', 'did-O', 'not-O', 'alter-O', 'seizure-B-Disease', 'threshold-O', '.-O']
['A-O', 'naloxone-B-Chemical', '(-O', '5-O', 'mg-O', '/-O', 'kg-O', ')-O', 'challenge-O', 'was-O', 'also-O', 'ineffective-O', 'in-O', 'altering-O', 'the-O', 'seizure-B-Disease', 'thresholds-O', 'of-O', 'either-O', 'control-O', 'of-O', 'MSG-B-Chemical', ',-O', 'treated-O', 'mice-O', '.-O']
['Flurothyl-B-Chemical', 'ether-O', 'produced-O', 'hypothermia-B-Disease', 'which-O', 'was-O', 'correlated-O', 'with-O', 'the-O', 'duration-O', 'of-O', 'flurothyl-B-Chemical', 'exposure-O', ';-O', 'however-O', ',-O', 'the-O', 'relationship-O', 'of-O', 'hypothermia-B-Disease', 'to-O', 'seizure-B-Disease', 'induction-O', 'was-O', 'unclear-O', '.-O']
['Flurothyl-B-Chemical', 'seizure-B-Disease', 'testing-O', 'proved-O', 'to-O', 'be-O', 'a-O', 'rapid-O', 'and-O', 'reliable-O', 'technique-O', 'with-O', 'which-O', 'to-O', 'evaluate-O', 'seizure-B-Disease']
['Susceptibility-O', 'to-O', 'seizures-B-Disease', 'produced-O', 'by-O', 'pilocarpine-B-Chemical', 'in-O', 'rats-O', 'after-O', 'microinjection-O', 'of-O', 'isoniazid-B-Chemical', 'or-O', 'gamma-vinyl-GABA-B-Chemical', 'into-O', 'the-O', 'substantia-O', 'nigra-O', '.-O']
['Pilocarpine-B-Chemical', ',-O', 'given-O', 'intraperitoneally-O', 'to-O', 'rats-O', ',-O', 'reproduces-O', 'the-O', 'neuropathological-O', 'sequelae-O', 'of-O', 'temporal-B-Disease', 'lobe-I-Disease', 'epilepsy-I-Disease', 'and-O', 'provides-O', 'a-O', 'relevant-O', 'animal-O', 'model-O', 'for-O', 'studying-O', 'mechanisms-O', 'of-O', 'buildup-O', 'of-O', 'convulsive-O', 'activity-O', 'and-O', 'pathways-O', 'operative-O', 'in-O', 'the-O', 'generalization-O', 'and-O', 'propagation-O', 'of-O', 'seizures-O', 'within-O', 'the-O', 'forebrain-O', '.-O']
['In-O', 'the-O', 'present-O', 'study-O', ',-O', 'the-O', 'effects-O', 'of-O', 'manipulating-O', 'the-O', 'activity-O', 'of-O', 'the-O', 'gamma-aminobutyric-B-Chemical', 'acid-I-Chemical', '(-O', 'GABA-B-Chemical', ')-O', 'mediated-O', 'synaptic-O', 'inhibition-O', 'within-O', 'the-O', 'substantia-O', 'nigra-O', 'on-O', 'seizures-B-Disease', 'produced-O', 'by-O', 'pilocarpine-B-Chemical', 'in-O', 'rats-O', ',-O', 'were-O', 'investigated-O', '.-O']
['In-O', 'animals-O', 'pretreated-O', 'with-O', 'microinjections-O', 'of-O', 'isoniazid-B-Chemical', ',-O', '150-O', 'micrograms-O', ',-O', 'an-O', 'inhibitor-O', 'of-O', 'activity-O', 'of-O', 'the-O', 'GABA-B-Chemical', ',-O', 'synthesizing-O', 'enzyme-O', ',-O', 'L-glutamic-B-Chemical', 'acid-O', 'decarboxylase-O', ',-O', 'into-O', 'the-O', 'substantia-O', 'nigra-O', 'pars-O', 'reticulata-O', '(-O', 'SNR-O', ')-O', 'bilaterally-O', ',-O', 'non-O', ',-O', 'convulsant-O', 'doses-O', 'of-O', 'pilocarpine-B-Chemical', ',-O', '100-O', 'and-O', '200-O', 'mg-O', '/-O', 'kg-O', ',-O', 'resulted-O', 'in-O', 'severe-O', 'motor-O', 'limbic-O', 'seizures-B-Disease', 'and-O', 'status-B-Disease', 'epilepticus-I-Disease', '.-O']
['Electroencephalographic-O', 'and-O', 'behavioral-O', 'monitoring-O', 'revealed-O', 'a-O', 'profound-O', 'reduction-O', 'of-O', 'the-O', 'threshold-O', 'for-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'convulsions-B-Disease', '.-O']
['Morphological-O', 'analysis-O', 'of-O', 'frontal-O', 'forebrain-O', 'sections-O', 'with-O', 'light-O', 'microscopy-O', 'revealed-O', 'seizure-B-Disease', ',-O', 'related-O', 'damage-I-Disease', 'to-O', 'the-O', 'hippocampal-O', 'formation-O', ',-O', 'thalamus-O', ',-O', 'amygdala-O', ',-O', 'olfactory-O', 'cortex-O', ',-O', 'substantia-O', 'nigra-O', 'and-O', 'neocortex-O', ',-O', 'which-O', 'is-O', 'typically-O', 'observed-O', 'with-O', 'pilocarpine-B-Chemical', 'in-O', 'doses-O', 'exceeding-O', '350-O', 'mg-O', '/-O', 'kg-O', '.-O']
['Bilateral-O', 'intrastriatal-O', 'injections-O', 'of-O', 'isoniazid-B-Chemical', 'did-O', 'not-O', 'augment-O', 'seizures-B-Disease', 'produced-O', 'by-O', 'pilocarpine-B-Chemical', ',-O', '200-O', 'mg-O', '/-O', 'kg-O', '.-O']
['Application-O', 'of-O', 'an-O', 'irreversible-O', 'inhibitor-O', 'of-O', 'GABA-B-Chemical', 'transaminase-O', ',-O', 'gamma-vinyl-GABA-B-Chemical', '(-O', 'D,O-L-4-amino-hex-5-enoic-O', 'acid-O', ')-O', '5-O', 'micrograms-O', ',-O', 'into-O', 'the-O', 'SNR-O', ',-O', 'bilaterally-O', ',-O', 'suppressed-O', 'the-O', 'appearance-O', 'of-O', 'electrographic-O', 'and-O', 'behavioral-O', 'seizures-B-Disease', 'produced-O', 'by-O', 'pilocarpine-B-Chemical', ',-O', '380-O', 'mg-O', '/-O', 'kg-O', '.-O']
['This-O', 'treatment-O', 'was-O', 'also-O', 'sufficient-O', 'to-O', 'protect-O', 'animals-O', 'from-O', 'the-O', 'occurrence-O', 'of-O', 'brain-B-Disease', 'damage-I-Disease', '.-O']
['Microinjections-O', 'of-O', 'gamma-vinyl-GABA-B-Chemical', ',-O', '5-O', 'micrograms-O', ',-O', 'into-O', 'the-O', 'dorsal-O', 'striatum-O', ',-O', 'bilaterally-O', ',-O', 'failed-O', 'to-O', 'prevent-O', 'the-O', 'development-O', 'of-O', 'convulsions-B-Disease', 'produced-O', 'by-O', 'pilocarpine-B-Chemical', ',-O', '380-O', 'mg-O', '/-O', 'kg-O', '.-O']
['The-O', 'results-O', 'demonstrate-O', 'that-O', 'the-O', 'threshold-O', 'for-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', 'in-O', 'rats-O', 'is-O', 'subjected-O', 'to-O', 'the-O', 'regulation-O', 'of-O', 'the-O', 'GABA-B-Chemical']
['Non-O', ',-O', 'invasive-O', 'detection-O', 'of-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease', 'by-O', 'body-O', 'surface-O', 'electrocardiographic-O', 'mapping-O', 'after-O', 'dipyridamole-B-Chemical', 'infusion-O', '.-O']
['Electrocardiographic-O', 'changes-O', 'after-O', 'dipyridamole-B-Chemical', 'infusion-O', '(-O', '0-O', '.-O']
['568-O', 'mg-O', '/-O', 'kg-O', '/-O', '4-O', 'min-O', ')-O', 'were-O', 'studied-O', 'in-O', '41-O', 'patients-O', 'with-O', 'coronary-B-Disease', 'artery-O', 'disease-I-Disease', 'and-O', 'compared-O', 'with-O', 'those-O', 'after-O', 'submaximal-O', 'treadmill-O', 'exercise-O', 'by-O', 'use-O', 'of-O', 'the-O', 'body-O', 'surface-O', 'mapping-O', 'technique-O', '.-O']
['Patients-O', 'were-O', 'divided-O', 'into-O', 'three-O', 'groups-O', ';-O', '19-O', 'patients-O', 'without-O', 'myocardial-B-Disease', 'infarction-I-Disease', '(-O', 'non-O', ',-O', 'MI-O', 'group-O', ')-O', '14-O', 'with-O', 'anterior-O', 'infarction-I-Disease', '(-O', 'ANT-MI-O', ')-O', 'and-O', 'eight-O', 'with-O', 'inferior-O', 'infarction-I-Disease', '(-O', 'INF-MI-O', ')-O', '.-O', 'Eighty-O', ',-O', 'seven-O', 'unipolar-O', 'electrocardiograms-O', '(-O', 'ECGs-O', ')-O', 'distributed-O', 'over-O', 'the-O', 'entire-O', 'thoracic-O', 'surface-O', 'were-O', 'simultaneously-O', 'recorded-O', '.-O']
['After-O', 'dipyridamole-B-Chemical', ',-O', 'ischemic-B-Disease', 'ST-O', ',-O', 'segment-O', 'depression-O', '(-O', '0-O', '.-O']
['05-O', 'mV-O', 'or-O', 'more-O', ')-O', 'was-O', 'observed-O', 'in-O', '84-O', '%-O', 'of-O', 'the-O', 'non-O', ',-O', 'MI-B-Disease', 'group-O', ',-O', '29-O', '%-O', 'of-O', 'the-O', 'ANT-MI-B-Disease', 'group-O', ',-O', '63-O', '%-O', 'of-O', 'the-O', 'INF-MI-B-Disease', 'group-O', 'and-O', '61-O', '%-O', 'of-O', 'the-O', 'total-O', 'population-O', '.-O']
['Exercise-O', ',-O', 'induced-O', 'ST-O', 'depression-B-Disease', 'was-O', 'observed-O', 'in-O', '84-O', '%-O', 'of-O', 'the-O', 'non-O', ',-O', 'MI-B-Disease', 'group-O', ',-O', '43-O', '%-O', 'of-O', 'the-O', 'ANT-MI-B-Disease', 'group-O', ',-O', '38-O', '%-O', 'of-O', 'the-O', 'INF-MI-B-Disease', 'group-O', 'and-O', '61-O', '%-O', 'of-O', 'the-O', 'total-O', '.-O']
['For-O', 'individual-O', 'patients-O', ',-O', 'there-O', 'were-O', 'no-O', 'obvious-O', 'differences-O', 'between-O', 'the-O', 'body-O', 'surface-O', 'distribution-O', 'of-O', 'ST-B-Disease', 'depression-I-Disease', 'in-O', 'both-O', 'tests-O', '.-O']
['The-O', 'increase-O', 'in-O', 'pressure-O', 'rate-O', 'product-O', 'after-O', 'dipyridamole-B-Chemical', 'was-O', 'significantly-O', 'less-O', 'than-O', 'that-O', 'during-O', 'the-O', 'treadmill-O', 'exercise-O', '.-O']
['The-O', 'data-O', 'suggest-O', 'that-O', 'the-O', 'dipyridamole-B-Chemical', ',-O', 'induced-O', 'myocardial-B-Disease', 'ischemia-I-Disease', 'is-O', 'caused-O', 'by-O', 'the-O', 'inhomogenous-O', 'distribution-O', 'of-O', 'myocardial-O', 'blood-O', 'flow-O', '.-O']
['We-O', 'conclude-O', 'that-O', 'the-O', 'dipyridamole-B-Chemical', 'ECG-O', 'test-O', 'is-O', 'as-O', 'useful-O', 'as-O', 'the-O', 'exercise-O', 'ECG-O', 'test-O', 'for-O', 'the-O', 'assessment-O', 'of-O', 'coronary-O', 'artery-O', 'disease-B-Disease']
['Bradycardia-B-Disease', 'after-O', 'high-O', ',-O', 'dose-O', 'intravenous-O', 'methylprednisolone-B-Chemical', 'therapy-O', '.-O']
['In-O', '5-O', 'consecutive-O', 'patients-O', 'with-O', 'rheumatoid-B-Disease', 'arthritis-I-Disease', 'who-O', 'received-O', 'intravenous-O', 'high-O', 'dose-O', 'methylprednisolone-B-Chemical', '(-O', 'MP-O', ')-O', 'therapy-O', '(-O', '1-O', 'g-O', 'daily-O', 'for-O', '2-O', 'or-O', '3-O', 'consecutive-O', 'days-O', ')-O', 'a-O', 'decline-O', 'in-O', 'pulse-O', 'rate-O', 'was-O', 'observed-O', ',-O', 'most-O', 'pronounced-O', 'on-O', 'day-O', '4-O', '.-O']
['In-O', 'one-O', 'of-O', 'the-O', '5-O', 'patients-O', 'the-O', 'bradycardia-B-Disease', 'was-O', 'associated-O', 'with-O', 'complaints-O', 'of-O', 'substernal-O', 'pressure-O', '.-O']
['Reversal-O', 'to-O', 'normal-O', 'heart-O', 'rate-O', 'was-O', 'found-O', 'on-O', 'day-O', '7-O', '.-O']
['Electrocardiographic-O', 'registrations-O', 'showed-O', 'sinus-B-Disease', 'bradycardia-B-Disease', 'in-O', 'all-O', 'cases-O', '.-O']
['No-O', 'significant-O', 'changes-O', 'in-O', 'plasma-O', 'concentrations-O', 'of-O', 'electrolytes-O', 'were-O', 'found-O', '.-O']
['Careful-O', 'observation-O', 'of-O', 'patients-O', 'receiving-O', 'high-O', ',-O', 'dose-O', 'MP-B-Disease', 'is-O', 'recommended-O', '.-O']
['High-O', ',-O', 'dose-O', 'MP-B-Disease', 'may-O', 'be-O', 'contraindicated-O', 'in-O', 'patients-O', 'with-O', 'known-O', 'heart-B-Disease', 'disease-I-Disease']
['Two-O', 'cases-O', 'of-O', 'downbeat-B-Disease', 'nystagmus-B-Disease', 'and-O', 'oscillopsia-B-Disease', 'associated-O', 'with-O', 'carbamazepine-B-Chemical', '.-O']
['Downbeat-O', 'nystagmus-B-Disease', 'is-O', 'often-O', 'associated-O', 'with-O', 'structural-O', 'lesions-O', 'at-O', 'the-O', 'craniocervical-O', 'junction-O', ',-O', 'but-O', 'has-O', 'occasionally-O', 'been-O', 'reported-O', 'as-O', 'a-O', 'manifestation-O', 'of-O', 'metabolic-O', 'imbalance-O', 'or-O', 'drug-O', 'intoxication-O', '.-O']
['We-O', 'recorded-O', 'the-O', 'eye-O', 'movements-O', 'of-O', 'two-O', 'patients-O', 'with-O', 'reversible-O', 'downbeat-O', 'nystagmus-B-Disease', 'related-O', 'to-O', 'carbamazepine-B-Chemical', 'therapy-O', '.-O']
['The-O', 'nystagmus-B-Disease', 'of-O', 'both-O', 'patients-O', 'resolved-O', 'after-O', 'reduction-O', 'of-O', 'the-O', 'serum-O', 'carbamazepine-B-Chemical', 'levels-O', '.-O']
['Neuroradiologic-O', 'investigations-O', 'including-O', 'magnetic-O', 'resonance-O', 'imaging-O', 'scans-O', 'in-O', 'both-O', 'patients-O', 'showed-O', 'no-O', 'evidence-O', 'of-O', 'intracranial-O', 'abnormality-B-Disease', '.-O']
['In-O', 'patients-O', 'with-O', 'downbeat-B-Disease', 'nystagmus-I-Disease']
['Improvement-O', 'by-O', 'denopamine-B-Chemical', '(', 'TA-064-B-Chemical', ')', 'of-O', 'pentobarbital-B-Chemical', ',-O', 'induced-O', 'cardiac-O', 'failure-B-Disease', 'in-O', 'the-O', 'dog-O', 'heart-O', ',-O', 'lung-O', 'preparation-O', '.-O']
['The-O', 'efficacy-O', 'of-O', 'denopamine-B-Chemical', ',-O', 'an-O', 'orally-O', 'active-O', 'beta-O', '1-O', ',-O', 'adrenoceptor-O', 'agonist-O', ',-O', 'in-O', 'improving-O', 'cardiac-O', 'failure-B-Disease', 'was-O', 'assessed-O', 'in-O', 'dog-O', 'heart-O', ',-O', 'lung-O', 'preparations-O', '.-O']
['Cardiac-O', 'functions-O', 'depressed-O', 'by-O', 'pentobarbital-B-Chemical', '(-O', '118-O', '+-O', '28-O', 'mg-O', ';-O', 'mean-O', 'value-O', '+-O', 'SD-O', ')-O', 'such-O', 'that-O', 'cardiac-O', 'output-O', 'and-O', 'maximum-O', 'rate-O', 'of-O', 'rise-O', 'of-O', 'left-O', 'ventricular-O', 'pressure-O', '(-O', 'LV-O', 'dP-O', '/-O', 'dt-O', 'max-O', ')-O', 'had-O', 'been-O', 'reduced-O', 'by-O', 'about-O', '35-O', '%-O', 'and-O', '26-O', '%-O', 'of-O', 'the-O', 'respective-O', 'controls-O', 'were-O', 'improved-O', 'by-O', 'denopamine-B-Chemical', '(-O', '10-O', ',-O', '300-O', 'micrograms-O', ')-O', 'in-O', 'a-O', 'dose-O', ',-O', 'dependent-O', 'manner-O', '.-O']
['With-O', '100-O', 'micrograms-O', 'denopamine-B-Chemical', ',-O', 'almost-O', 'complete-O', 'restoration-O', 'of-O', 'cardiac-O', 'performance-O', 'was-O', 'attained-O', ',-O', 'associated-O', 'with-O', 'a-O', 'slight-O', 'increase-O', 'in-O', 'heart-O', 'rate-O', '.-O']
['No-O', 'arrhythmias-B-Disease', 'were-O', 'induced-O', 'by-O', 'these-O', 'doses-O', 'of-O', 'denopamine-B-Chemical', '.-O']
['The-O', 'results-O', 'warrant-O', 'clinical-O', 'trials-O', 'of-O', 'denopamine-B-Chemical', 'in-O', 'the-O', 'treatment-O', 'of-O', 'cardiac-B-Disease', 'failure-I-Disease']
['Clonazepam-B-Chemical', 'monotherapy-O', 'for-O', 'epilepsy-B-Disease', 'in-O', 'childhood-O', '.-O']
['Sixty-O', 'patients-O', '(-O', 'age-O', ',-O', 'range-O', 'one-O', 'month-O', 'to-O', '14-O', 'years-O', ')-O', 'with-O', 'other-O', 'types-O', 'of-O', 'epilepsy-B-Disease', 'than-O', 'infantile-O', 'spasms-B-Disease', 'were-O', 'treated-O', 'with-O', 'clonazepam-B-Chemical', '.-O']
['Disappearance-O', 'of-O', 'seizures-B-Disease', 'and-O', 'normalization-O', 'of-O', 'abnormal-O', 'EEG-O', 'with-O', 'disappearance-O', 'of-O', 'seizures-B-Disease', 'were-O', 'recognized-O', 'in-O', '77-O', '%-O', 'and-O', '50-O', ',-O', 'respectively-O', '.-O']
['Seizures-B-Disease', 'disappeared-O', 'in-O', '71-O', '%-O', 'of-O', 'the-O', 'patients-O', 'with-O', 'generalized-O', 'seizures-B-Disease', 'and-O', '89-O', '%-O', 'of-O', 'partial-O', 'seizures-B-Disease', '.-O']
['Improvement-O', 'of-O', 'abnormal-O', 'EEG-O', 'was-O', 'noticed-O', 'in-O', '76-O', '%-O', 'of-O', 'diffuse-O', 'paroxysms-B-Disease', 'and-O', 'in-O', '67-O', '%-O', 'of-O', 'focal-O', 'paroxysms-B-Disease', '.-O']
['In-O', 'excellent-O', 'cases-O', ',-O', 'mean-O', 'effective-O', 'dosages-O', 'were-O', '0-O', '.-O']
['086-O', '+-O', '0-O', '.-O']
['021-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', 'in-O', 'infants-O', 'and-O', '0-O', '.-O']
['057-O', '+-O', '0-O', '.-O']
['022-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', 'in-O', 'schoolchildren-O', ',-O', 'this-O', 'difference-O', 'was-O', 'statistically-O', 'significant-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['005-O', ').-O', 'The-O', 'incidence-O', 'of-O', 'side-O', 'effects-O', 'such-O', 'as-O', 'drowsiness-B-Disease', 'and-O', 'ataxia-B-Disease']
['Postmarketing-O', 'study-O', 'of-O', 'timolol-B-Chemical', ',-O', 'hydrochlorothiazide-B-Chemical', 'antihypertensive-O', 'therapy-O', '.-O']
['A-O', 'postmarketing-O', 'surveillance-O', 'study-O', 'was-O', 'conducted-O', 'to-O', 'determine-O', 'the-O', 'safety-O', 'and-O', 'efficacy-O', 'of-O', 'a-O', 'fixed-O', ',-O', 'ratio-O', 'combination-O', 'containing-O', '10-O', 'mg-O', 'of-O', 'timolol-B-Chemical', 'maleate-I-Chemical', 'and-O', '25-O', 'mg-O', 'of-O', 'hydrochlorothiazide-B-Chemical', ',-O', 'administered-O', 'twice-O', 'daily-O', 'for-O', 'one-O', 'month-O', 'to-O', 'hypertensive-B-Disease', 'patients-O', '.-O']
['Data-O', 'on-O', '9-O', ',-O', '037-O', 'patients-O', 'were-O', 'collected-O', 'by-O', '1-O', ',-O', '455-O', 'participating-O', 'physicians-O', '.-O']
['Mean-O', 'systolic-O', 'blood-O', 'pressure-O', 'decreased-O', '25-O', 'mmHg-O', 'and-O', 'mean-O', 'diastolic-O', 'blood-O', 'pressure-O', 'declined-O', '15-O', 'mmHg-O', 'after-O', 'one-O', 'month-O', 'of-O', 'timolol-B-Chemical', ',', 'hydrochlorothiazide-B-Chemical', 'therapy-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ',-O', 'both-O', 'comparisons-O', ')-O', 'Age-O', ',-O', 'race-O', ',-O', 'and-O', 'sex-O', 'appeared-O', 'to-O', 'have-O', 'no-O', 'influence-O', 'on-O', 'the-O', 'decrease-O', 'in-O', 'blood-O', 'pressure-O', '.-O']
['The-O', 'antihypertensive-O', 'effect-O', 'of-O', 'the-O', 'drug-O', 'was-O', 'greater-O', 'in-O', 'patients-O', 'with-O', 'more-O', 'severe-O', 'hypertension-B-Disease', '.-O']
['Overall-O', ',-O', '1-O', ',-O', '453-O', 'patients-O', 'experienced-O', 'a-O', 'total-O', 'of-O', '2-O', ',-O', '658-O', 'adverse-O', 'events-O', ',-O', 'the-O', 'most-O', 'common-O', 'being-O', 'fatigue-B-Disease', ',-O', 'dizziness-B-Disease', ',-O', 'and-O', 'weakness-B-Disease']
['Salicylate-B-Chemical', 'nephropathy-B-Disease', 'in-O', 'the-O', 'Gunn-O', 'rat-O', ':-O', 'potential-O', 'role-O', 'of-O', 'prostaglandins-B-Chemical', '.-O']
['We-O', 'examined-O', 'the-O', 'potential-O', 'role-O', 'of-O', 'prostaglandins-B-Chemical', 'in-O', 'the-O', 'development-O', 'of-O', 'analgesic-B-Disease', 'nephropathy-B-Disease', 'in-O', 'the-O', 'Gunn-O', 'strain-O', 'of-O', 'rat-O', '.-O']
['The-O', 'homozygous-O', 'Gunn-O', 'rats-O', 'have-O', 'unconjugated-B-Disease', 'hyperbilirubinemia-B-Disease', 'due-O', 'to-O', 'the-O', 'absence-O', 'of-O', 'glucuronyl-O', 'transferase-O', ',-O', 'leading-O', 'to-O', 'marked-O', 'bilirubin-B-Chemical', 'deposition-O', 'in-O', 'renal-O', 'medulla-O', 'and-O', 'papilla-O', '.-O']
['These-O', 'rats-O', 'are-O', 'also-O', 'highly-O', 'susceptible-O', 'to-O', 'develop-O', 'papillary-O', 'necrosis-B-Disease', 'with-O', 'analgesic-O', 'administration-O', '.-O']
['We-O', 'used-O', 'homozygous-O', '(-O', 'jj-O', ')-O', 'and-O', 'phenotypically-O', 'normal-O', 'heterozygous-O', '(-O', 'jJ-O', ')-O', 'animals-O', '.-O']
['Four-O', 'groups-O', 'of-O', 'rats-O', '(-O', 'n-O', '=-O', '7-O', ')-O', 'were-O', 'studied-O', ':-O', 'jj-O', 'and-O', 'jJ-O', 'rats-O', 'treated-O', 'either-O', 'with-O', 'aspirin-B-Chemical', '300-O', 'mg-O', '/-O', 'kg-O', 'every-O', 'other-O', 'day-O', 'or-O', 'sham-O', ',-O', 'treated-O', '.-O']
['After-O', 'one-O', 'week-O', ',-O', 'slices-O', 'of-O', 'cortex-O', ',-O', 'outer-O', 'and-O', 'inner-O', 'medulla-O', 'from-O', 'one-O', 'kidney-O', 'were-O', 'incubated-O', 'in-O', 'buffer-O', 'and-O', 'prostaglandin-B-Chemical', 'synthesis-O', 'was-O', 'determined-O', 'by-O', 'radioimmunoassay-O', '.-O']
['The-O', 'other-O', 'kidney-O', 'was-O', 'examined-O', 'histologically-O', '.-O']
['A-O', 'marked-O', 'corticomedullary-O', 'gradient-O', 'of-O', 'prostaglandin-B-Chemical', 'synthesis-O', 'was-O', 'observed-O', 'in-O', 'all-O', 'groups-O', '.-O']
['PGE2-B-Chemical', 'synthesis-O', 'was-O', 'significantly-O', 'higher-O', 'in-O', 'outer-O', 'medulla-O', ',-O', 'but-O', 'not-O', 'cortex-O', 'or-O', 'inner-O', 'medulla-O', ',-O', 'of-O', 'jj-O', '(-O', '38-O', '+-O', '6-O', 'ng-O', '/-O', 'mg-O', 'prot-O', ')-O', 'than-O', 'jJ-O', 'rats-O', '(-O', '15-O', '+-O', '3-O', ')-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ').-O', 'Aspirin-B-Chemical', 'treatment-O', 'reduced-O', 'PGE2-B-Chemical', 'synthesis-O', 'in-O', 'all-O', 'regions-O', ',-O', 'but-O', 'outer-O', 'medullary-O', 'PGE2-B-Chemical', 'remained-O', 'higher-O', 'in-O', 'jj-O', '(-O', '18-O', '+-O', '3-O', ')-O', 'than-O', 'jJ-O', 'rats-O', '(-O', '9-O', '+-O', '2-O', ')-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'PGF2-B-Chemical', 'alpha-O', 'was-O', 'also-O', 'significantly-O', 'higher-O', 'in-O', 'the-O', 'outer-O', 'medulla-O', 'of-O', 'jj-O', 'rats-O', 'with-O', 'and-O', 'without-O', 'aspirin-B-Chemical', 'administration-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'The-O', 'changes-O', 'in-O', 'renal-O', 'prostaglandin-B-Chemical', 'synthesis-O', 'were-O', 'accompanied-O', 'by-O', 'evidence-O', 'of-O', 'renal-B-Disease', 'damage-I-Disease', 'in-O', 'aspirin-B-Chemical', ',-O', 'treated-O', 'jj-O', 'but-O', 'not-O', 'jJ-O', 'rats-O', 'as-O', 'evidenced-O', 'by-O', ':-O', 'increased-O', 'incidence-O', 'and-O', 'severity-O', 'of-O', 'hematuria-B-Disease', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ')-O', 'increased-O', 'serum-O', 'creatinine-B-Chemical', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ')-O', 'and-O', 'increase-O', 'in-O', 'outer-O', 'medullary-O', 'histopathologic-O', 'lesions-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['005-O', 'compared-O', 'to-O', 'either-O', 'sham-O', ',-O', 'treated-O', 'jj-O', 'or-O', 'aspirin-B-Chemical', ',-O', 'treated-O', 'jJ-O', ')-O', 'These-O', 'results-O', 'suggest-O', 'that-O', 'enhanced-O', 'prostaglandin-B-Chemical', 'synthesis-O', 'contributes-O', 'to-O', 'maintenance-O', 'of-O', 'renal-O', 'function-O', 'and-O', 'morphological-O', 'integrity-O', ',-O', 'and-O', 'that-O', 'inhibition-O', 'of-O', 'prostaglandin-B-Chemical', 'synthesis-O', 'may-O', 'lead-O', 'to-O', 'pathological-O', 'renal-O', 'medullary-O', 'lesions-O', 'and-O', 'deterioration-O', 'of-O', 'renal-O', 'function-O']
['Prophylactic-O', 'lidocaine-B-Chemical', 'in-O', 'the-O', 'early-O', 'phase-O', 'of-O', 'suspected-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['Four-O', 'hundred-O', 'two-O', 'patients-O', 'with-O', 'suspected-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'seen-O', 'within-O', '6-O', 'hours-O', 'of-O', 'the-O', 'onset-O', 'of-O', 'symptoms-O', 'entered-O', 'a-O', 'double-O', ',-O', 'blind-O', 'randomized-O', 'trial-O', 'of-O', 'lidocaine-B-Chemical', 'vs-O', 'placebo-O', '.-O']
['During-O', 'the-O', '1-O', 'hour-O', 'after-O', 'administration-O', 'of-O', 'the-O', 'drug-O', 'the-O', 'incidence-O', 'of-O', 'ventricular-B-Disease', 'fibrillation-I-Disease', 'or-O', 'sustained-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'among-O', 'the-O', '204-O', 'patients-O', 'with-O', 'acute-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'was-O', 'low-O', ',-O', '1-O', '.-O']
['5-O', '.-O', 'Lidocaine-B-Chemical', ',-O', 'given-O', 'in-O', 'a-O', '300-O', 'mg-O', 'dose-O', 'intramuscularly-O', 'followed-O', 'by-O', '100-O', 'mg-O', 'intravenously-O', ',-O', 'did-O', 'not-O', 'prevent-O', 'sustained-O', 'ventricular-B-Disease', 'tachycardia-B-Disease', ',-O', 'although-O', 'there-O', 'was-O', 'a-O', 'significant-O', 'reduction-O', 'in-O', 'the-O', 'number-O', 'of-O', 'patients-O', 'with-O', 'warning-O', 'arrhythmias-B-Disease', 'between-O', '15-O', 'and-O', '45-O', 'minutes-O', 'after-O', 'the-O', 'administration-O', 'of-O', 'lidocaine-B-Chemical', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'The-O', 'average-O', 'plasma-O', 'lidocaine-B-Chemical', 'level-O', '10-O', 'minutes-O', 'after-O', 'administration-O', 'for-O', 'patients-O', 'without-O', 'a-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'was-O', 'significantly-O', 'higher-O', 'than-O', 'that-O', 'for-O', 'patients-O', 'with-O', 'an-O', 'acute-B-Disease', 'infarction-I-Disease', '.-O']
['The-O', 'mean-O', 'plasma-O', 'lidocaine-B-Chemical', 'level-O', 'of-O', 'patients-O', 'on-O', 'beta-O', ',-O', 'blocking-O', 'agents-O', 'was-O', 'no-O', 'different-O', 'from-O', 'that-O', 'in-O', 'patients-O', 'not-O', 'on-O', 'beta-O', 'blocking-O', 'agents-O', '.-O']
['During-O', 'the-O', '1-O', ',-O', 'hour-O', 'study-O', 'period-O', ',-O', 'the-O', 'incidence-O', 'of-O', 'central-O', 'nervous-O', 'system-O', 'side-O', 'effects-O', 'was-O', 'significantly-O', 'greater-O', 'in-O', 'the-O', 'lidocaine-B-Chemical', 'group-O', ',-O', 'hypotension-B-Disease', 'occurred-O', 'in-O', '11-O', 'patients-O', ',-O', 'nine-O', 'of-O', 'whom-O', 'had-O', 'received-O', 'lidocaine-B-Chemical', ',-O', 'and-O', 'four-O', 'patients-O', 'died-O', 'from-O', 'asystole-B-Disease', ',-O', 'three-O', 'of-O', 'whom-O', 'had-O', 'had-O', 'lidocaine-B-Chemical', '.-O']
['We-O', 'cannot-O', 'advocate-O', 'the-O', 'administration-O', 'of-O', 'lidocaine-B-Chemical', 'prophylactically-O', 'in-O', 'the-O', 'early-O', 'hours-O', 'of-O', 'suspected-O', 'myocardial-B-Disease', 'infarction-I-Disease']
['Evidence-O', 'for-O', 'a-O', 'cholinergic-O', 'role-O', 'in-O', 'haloperidol-B-Chemical', ',-O', 'induced-O', 'catalepsy-B-Disease', '.-O']
['Experiments-O', 'in-O', 'mice-O', 'tested-O', 'previous-O', 'evidence-O', 'that-O', 'activation-O', 'of-O', 'cholinergic-O', 'systems-O', 'promotes-O', 'catalepsy-B-Disease', 'and-O', 'that-O', 'cholinergic-O', 'mechanisms-O', 'need-O', 'to-O', 'be-O', 'intact-O', 'for-O', 'full-O', 'expression-O', 'of-O', 'neuroleptic-O', ',-O', 'induced-O', 'catalepsy-B-Disease', '.-O']
['Large-O', 'doses-O', 'of-O', 'the-O', 'cholinomimetic-O', ',-O', 'pilocarpine-B-Chemical', ',-O', 'could-O', 'induce-O', 'catalepsy-B-Disease', 'when-O', 'peripheral-O', 'cholinergic-O', 'receptors-O', 'were-O', 'blocked-O', '.-O']
['Low-O', 'doses-O', 'of-O', 'pilocarpine-B-Chemical', 'caused-O', 'a-O', 'pronounced-O', 'enhancement-O', 'of-O', 'the-O', 'catalepsy-B-Disease', 'that-O', 'was-O', 'induced-O', 'by-O', 'the-O', 'dopaminergic-O', 'blocker-O', ',-O', 'haloperidol-B-Chemical', '.-O']
['A-O', 'muscarinic-O', 'receptor-O', 'blocker-O', ',-O', 'atropine-B-Chemical', ',-O', 'disrupted-O', 'haloperidol-B-Chemical', ',-O', 'induced-O', 'catalepsy-B-Disease', '.-O']
['Intracranial-O', 'injection-O', 'of-O', 'an-O', 'acetylcholine-B-Chemical', ',-O', 'synthesis-O', 'inhibitor-O', ',-O', 'hemicholinium-B-Chemical', ',-O', 'prevented-O', 'the-O', 'catalepsy-B-Disease', 'that-O', 'is-O', 'usually-O', 'induced-O', 'by-O', 'haloperidol-B-Chemical', '.-O']
['These-O', 'findings-O', 'suggest-O', 'the-O', 'hypothesis-O', 'that-O', 'the-O', 'catalepsy-B-Disease', 'that-O', 'is-O', 'produced-O', 'by-O', 'neuroleptics-O', 'such-O', 'as-O', 'haloperidol-B-Chemical', 'is-O', 'actually-O', 'mediated-O', 'by-O', 'intrinsic-O', 'central-O', 'cholinergic-O', 'systems-O', '.-O']
['Alternatively-O', ',-O', 'activation-O', 'of-O', 'central-O', 'cholinergic-O', 'systems-O', 'could-O', 'promote-O', 'catalepsy-B-Disease']
['Cardiovascular-B-Disease', 'dysfunction-I-Disease', 'and-O', 'hypersensitivity-B-Disease', 'to-O', 'sodium-B-Chemical', 'pentobarbital-B-Chemical', 'induced-O', 'by-O', 'chronic-O', 'barium-B-Chemical', 'chloride-I-Chemical', 'ingestion-O', '.-O']
['Barium-B-Chemical', ',-O', 'supplemented-O', 'Long-O', ',-O', 'Evans-O', 'hooded-O', 'rats-O', 'were-O', 'characterized-O', 'by-O', 'a-O', 'persistent-O', 'hypertension-B-Disease', 'that-O', 'was-O', 'evident-O', 'after-O', '1-O', 'month-O', 'of-O', 'barium-B-Chemical', '(-O', '100-O', 'micrograms-O', '/-O', 'ml-O', 'mineral-O', 'fortified-O', 'water-O', ')-O', 'treatment-O', '.-O']
['Analysis-O', 'of-O', 'in-O', 'vivo-O', 'myocardial-O', 'excitability-O', ',-O', 'contractility-O', ',-O', 'and-O', 'metabolic-O', 'characteristics-O', 'at-O', '16-O', 'months-O', 'revealed-O', 'other-O', 'significant-O', 'barium-B-Chemical', '-O', 'induced-O', 'disturbances-O', 'within-O', 'the-O', 'cardiovascular-O', 'system-O', '.-O']
['The-O', 'most-O', 'distinctive-O', 'aspect-O', 'of-O', 'the-O', 'barium-B-Chemical', 'effect-O', 'was-O', 'a-O', 'demonstrated-O', 'hypersensitivity-O', 'of-O', 'the-O', 'cardiovascular-O', 'system-O', 'to-O', 'sodium-B-Chemical', 'pentobarbital-B-Chemical', '.-O']
['Under-O', 'barbiturate-B-Chemical', 'anesthesia-O', ',-O', 'virtually-O', 'all-O', 'of-O', 'the-O', 'myocardial-B-Disease', 'contractile-O', 'indices-O', 'were-O', 'depressed-O', 'significantly-O', 'in-O', 'barium-B-Chemical', ',-O', 'exposed-O', 'rats-O', 'relative-O', 'to-O', 'the-O', 'corresponding-O', 'control-O', ',-O', 'fed-O', 'rats-O', '.-O']
['The-O', 'lack-O', 'of-O', 'a-O', 'similar-O', 'response-O', 'to-O', 'ketamine-B-Chemical', 'and-O', 'xylazine-B-Chemical', 'anesthesia-O', 'revealed-O', 'that-O', 'the-O', 'cardiovascular-O', 'actions-O', 'of-O', 'sodium-B-Chemical', 'pentobarbital-B-Chemical', 'in-O', 'barium-B-Chemical', ',-O', 'treated-O', 'rats-O', 'were-O', 'linked-O', 'specifically-O', 'to-O', 'this-O', 'anesthetic-O', ',-O', 'and-O', 'were-O', 'not-O', 'representative-O', 'of-O', 'a-O', 'generalized-O', 'anesthetic-O', 'response-O', '.-O']
['Other-O', 'myocardial-B-Disease', 'pathophysiologic-O', 'and-O', 'metabolic-O', 'changes-O', 'induced-O', 'by-O', 'barium-B-Chemical', 'were-O', 'manifest-O', ',-O', 'irrespective-O', 'of-O', 'the-O', 'anesthetic-O', 'employed-O', '.-O']
['The-O', 'contractile-O', 'element-O', 'shortening-O', 'velocity-O', 'of-O', 'the-O', 'cardiac-O', 'muscle-O', 'fibers-O', 'was-O', 'significantly-O', 'slower-O', 'in-O', 'both-O', 'groups-O', 'of-O', 'barium-B-Chemical', ',-O', 'treated-O', 'rats-O', 'relative-O', 'to-O', 'the-O', 'control-O', 'groups-O', ',-O', 'irrespective-O', 'of-O', 'the-O', 'anesthetic-O', 'regimen-O', '.-O']
['Similarly-O', ',-O', 'significant-O', 'disturbances-O', 'in-O', 'myocardial-O', 'energy-O', 'metabolism-O', 'were-O', 'detected-O', 'in-O', 'the-O', 'barium-B-Chemical', 'exposed-O', 'rats-O', 'which-O', 'were-O', 'consistent-O', 'with-O', 'the-O', 'reduced-O', 'contractile-O', 'element-O', 'shortening-O', 'velocity-O', '.-O']
['In-O', 'addition-O', ',-O', 'the-O', 'excitability-O', 'of-O', 'the-O', 'cardiac-O', 'conduction-O', 'system-O', 'was-O', 'depressed-O', 'preferentially-O', 'in-O', 'the-O', 'atrioventricular-O', 'nodal-O', 'region-O', 'of-O', 'hearts-O', 'from-O', 'barium-B-Chemical', ',-O', 'exposed-O', 'rats-O', '.-O']
['Overall-O', ',-O', 'the-O', 'altered-O', 'cardiac-O', 'contractility-O', 'and-O', 'excitability-O', 'characteristics-O', ',-O', 'the-O', 'myocardial-O', 'metabolic-O', 'disturbances-O', ',-O', 'and-O', 'the-O', 'hypersensitivity-O', 'of-O', 'the-O', 'cardiovascular-O', 'system-O', 'to-O', 'sodium-B-Chemical', 'pentobarbital-B-Chemical', 'suggest-O', 'the-O', 'existence-O', 'of-O', 'a-O', 'heretofore-O', 'undescribed-O', 'cardiomyopathic-B-Disease', 'disorder-O', 'induced-O', 'by-O', 'chronic-O', 'barium-B-Chemical', 'exposure-O', '.-O']
['These-O', 'experimental-O', 'findings-O', 'represent-O', 'the-O', 'first-O', 'indication-O', 'that-O', 'life-O', ',-O', 'long-O', 'barium-B-Chemical']
['Propranolol-B-Chemical', 'antagonism-O', 'of-O', 'phenylpropanolamine-B-Chemical', ',-O', 'induced-O', 'hypertension-B-Disease', '.-O']
['Phenylpropanolamine-B-Chemical', '(-O', 'PPA-B-Chemical', ')-O', 'overdose-O', 'can-O', 'cause-O', 'severe-O', 'hypertension-B-Disease', ',-O', 'intracerebral-B-Disease', 'hemorrhage-I-Disease', ',-O', 'and-O', 'death-B-Disease', '.-O']
['We-O', 'studied-O', 'the-O', 'efficacy-O', 'and-O', 'safety-O', 'of-O', 'propranolol-B-Chemical', 'in-O', 'the-O', 'treatment-O', 'of-O', 'PPA-B-Chemical', ',-O', 'induced-O', 'hypertension-B-Disease', '.-O']
['Subjects-O', 'received-O', 'propranolol-B-Chemical', 'either-O', 'by-O', 'mouth-O', 'for-O', '48-O', 'hours-O', 'before-O', 'PPA-B-Chemical', 'or-O', 'as-O', 'a-O', 'rapid-O', 'intravenous-O', 'infusion-O', 'after-O', 'PPA-B-Chemical', '.-O']
['PPA-O', ',-O', '75-O', 'mg-O', 'alone-O', ',-O', 'increased-O', 'blood-O', 'pressure-O', '(-O', '31-O', '+-O', '14-O', 'mm-O', 'Hg-O', 'systolic-O', ',-O', '20-O', '+-O', '5-O', 'mm-O', 'Hg-O', 'diastolic-O', ')-O', 'and-O', 'propranolol-B-Chemical', 'pretreatment-O', 'antagonized-O', 'this-O', 'increase-O', '(-O', '12-O', '+-O', '10-O', 'mm-O', 'Hg-O', 'systolic-O', ',-O', '10-O', '+-O', '7-O', 'mm-O', 'Hg-O', 'diastolic-O', ')-O', '.-O', 'Intravenous-O', 'propranolol-B-Chemical', 'after-O', 'PPA-O', 'also-O', 'decreased-O', 'blood-O', 'pressure-O', '.-O']
['Left-O', 'ventricular-O', 'function-O', '(-O', 'assessed-O', 'by-O', 'echocardiography-O', ')-O', 'showed-O', 'that-O', 'PPA-B-Chemical', 'increased-O', 'the-O', 'stroke-O', 'volume-O', '30-O', '(-O', 'from-O', '62-O', '.-O']
['5-O', '+-O', '20-O', '.-O']
['9-O', 'to-O', '80-O', '.-O']
['8-O', '+-O', '22-O', '.-O']
['4-O', 'ml-O', ')-O', 'the-O', 'ejection-O', 'fraction-O', '9-O', '(-O', 'from-O', '64-O', '%+-O', '10-O', '%-O', 'to-O', '70-O', '%+-O', '7-O', ')-O', 'and-O', 'cardiac-O', 'output-O', '14-O', '(-O', 'from-O', '3-O', '.-O']
['6-O', '+-O', '0-O', '.-O']
['6-O', 'to-O', '4-O', '.-O']
['1-O', '+-O', '1-O', '.-O']
['0-O', 'L-O', '/-O', 'min-O', ')-O', '.', 'Intravenous-O', 'propranolol-B-Chemical', 'reversed-O', 'these-O', 'effects-O', '.-O']
['Systemic-O', 'vascular-O', 'resistance-O', 'was-O', 'increased-O', 'by-O', 'PPA-B-Chemical', '28-O', '(-O', 'from-O', '1710-O', '+-O', '200-O', 'to-O', '2190-O', '+-O', '700-O', 'dyne-O', 'X-O', 'sec-O', '/-O', 'cm5-O', ')-O', 'and-O', 'was-O', 'further-O', 'increased-O', 'by-O', 'propranolol-B-Chemical', '22-O', '(-O', 'to-O', '2660-O', '+-O', '1200-O', 'dyne-O', 'X-O', 'sec-O', '/-O', 'cm5-O', ')-O', '.', 'We-O', 'conclude-O', 'that-O', 'PPA-B-Chemical', 'increases-O', 'blood-O', 'pressure-O', 'by-O', 'increasing-O', 'systemic-O', 'vascular-O', 'resistance-O', 'and-O', 'cardiac-O', 'output-O', ',-O', 'and-O', 'that-O', 'propranolol-B-Chemical', 'antagonizes-O', 'this-O', 'increase-O', 'by-O', 'reversing-O', 'the-O', 'effect-O', 'of-O', 'PPA-B-Chemical', 'on-O', 'cardiac-O', 'output-O', '.-O']
['That-O', 'propranolol-B-Chemical', 'antagonizes-O', 'the-O', 'pressor-O', 'effect-O', 'of-O', 'PPA-B-Chemical', 'is-O', 'in-O', 'contrast-O', 'to-O', 'the-O', 'interaction-O', 'in-O', 'which-O', 'propranolol-B-Chemical', 'enhances-O', 'the-O', 'pressor-O', 'effect-O', 'of-O', 'norepinephrine-B-Chemical', '.-O']
['This-O', 'is-O', 'probably-O', 'because-O', 'PPA-B-Chemical', 'has-O', 'less-O', 'beta-O', '2-O', 'activity-O', 'than-O', 'does-O', 'norepinephrine-B-Chemical']
['Mesangial-O', 'function-O', 'and-O', 'glomerular-O', 'sclerosis-B-Disease', 'in-O', 'rats-O', 'with-O', 'aminonucleoside-B-Chemical', 'nephrosis-B-Disease', '.-O']
['The-O', 'possible-O', 'relationship-O', 'between-O', 'mesangial-O', 'dysfunction-O', 'and-O', 'development-O', 'of-O', 'glomerular-O', 'sclerosis-B-Disease', 'was-O', 'studied-O', 'in-O', 'the-O', 'puromycin-B-Chemical', 'aminonucleoside-I-Chemical', '(-O', 'PAN-B-Chemical', ')--O', 'model-O', '.-O']
['Five-O', 'male-O', 'Wistar-O', 'rats-O', 'received-O', 'repeated-O', 'subcutaneous-O', 'PAN-B-Chemical', 'injections-O', ';-O', 'five-O', 'controls-O', 'received-O', 'saline-O', 'only-O', '.-O']
['After-O', '4-O', 'weeks-O', 'the-O', 'PAN-B-Chemical', 'rats-O', 'were-O', 'severely-O', 'proteinuric-B-Disease', '(-O', '190-O', '+-O', '80-O', 'mg-O', '/-O', '24-O', 'hr-O', ')-O', 'and-O', 'all-O', 'rats-O', 'were-O', 'given-O', 'colloidal-O', 'carbon-B-Chemical', '(-O', 'CC-B-Chemical', ')-O', 'intravenously-O', '.-O']
['At-O', '5-O', 'months-O', 'glomerular-O', 'sclerosis-B-Disease', 'was-O', 'found-O', 'in-O', '7-O', '.-O']
['6-O', '+-O', '3-O', '.-O']
['4-O', '%-O', 'of-O', 'the-O', 'glomeruli-O', 'of-O', 'PAN-B-Chemical', 'rats-O', ';-O', 'glomeruli-O', 'of-O', 'the-O', 'controls-O', 'were-O', 'normal-O', '.-O']
['Glomeruli-O', 'of-O', 'PAN-B-Chemical', 'rats-O', 'contained-O', 'significantly-O', 'more-O', 'CC-B-Chemical', 'than-O', 'glomeruli-O', 'of-O', 'controls-O', '.-O']
['Glomeruli-O', 'with-O', 'sclerosis-B-Disease', 'contained-O', 'significantly-O', 'more-O', 'CC-B-Chemical', 'than-O', 'non-O', ',-O', 'sclerotic-B-Disease', 'glomeruli-O', 'in-O', 'the-O', 'same-O', 'kidneys-O', '.-O']
['CC-B-Chemical', 'was-O', 'preferentially-O', 'localized-O', 'within-O', 'the-O', 'sclerotic-B-Disease', 'areas-O', 'of-O', 'the-O', 'affected-O', 'glomeruli-O', '.-O']
['Since-O', 'mesangial-O', 'CC-B-Chemical', 'clearance-O', 'from-O', 'the-O', 'mesangium-O', 'did-O', 'not-O', 'change-O', 'during-O', 'chronic-O', 'PAN-B-Chemical', 'treatment-O', ',-O', 'we-O', 'conclude-O', 'that-O', 'this-O', 'preferential-O', 'CC-B-Chemical', 'localization-O', 'within-O', 'the-O', 'lesions-O', 'is-O', 'caused-O', 'by-O', 'an-O', 'increased-O', 'CC-B-Chemical', 'uptake-O', 'shortly-O', 'after-O', 'injection-O', 'in-O', 'apparent-O', 'vulnerable-O', 'areas-O', 'where-O', 'sclerosis-B-Disease', 'will-O', 'develop-O', 'subsequently-O', '.-O']
['Cluster-O', 'analysis-O', 'showed-O', 'a-O', 'random-O', 'distribution-O', 'of-O', 'lesions-O', 'in-O', 'the-O', 'PAN-B-Chemical', 'glomeruli-O', 'in-O', 'concordance-O', 'with-O', 'the-O', 'random-O', 'localization-O', 'of-O', 'mesangial-O', 'areas-O', 'with-O', 'dysfunction-O', 'in-O', 'this-O', 'model-O', '.-O']
['Similar-O', 'to-O', 'the-O', 'remnant-O', 'kidney-O', 'model-O', 'in-O', 'PAN-B-Chemical', 'nephrosis-B-Disease', 'the-O', 'development-O', 'of-O', 'glomerular-B-Disease', 'sclerosis-I-Disease']
['Relationship-O', 'between-O', 'nicotine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', 'and-O', 'hippocampal-O', 'nicotinic-O', 'receptors-O', '.-O']
['A-O', 'controversy-O', 'has-O', 'existed-O', 'for-O', 'several-O', 'years-O', 'concerning-O', 'the-O', 'physiological-O', 'relevance-O', 'of-O', 'the-O', 'nicotinic-O', 'receptor-O', 'measured-O', 'by-O', 'alpha-O', ',-O', 'bungarotoxin-B-Chemical', 'binding-O', '.-O']
['Using-O', 'mice-O', 'derived-O', 'from-O', 'a-O', 'classical-O', 'F2-O', 'and-O', 'backcross-O', 'genetic-O', 'design-O', ',-O', 'a-O', 'relationship-O', 'between-O', 'nicotine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', 'and-O', 'alpha-O', ',-O', 'bungarotoxin-B-Chemical', 'nicotinic-O', 'receptor-O', 'concentration-O', 'was-O', 'found-O', '.-O']
['Mice-O', 'sensitive-O', 'to-O', 'the-O', 'convulsant-O', 'effects-O', 'of-O', 'nicotine-B-Chemical', 'had-O', 'greater-O', 'alpha-O', ',-O', 'bungarotoxin-B-Chemical', 'binding-O', 'in-O', 'the-O', 'hippocampus-O', 'than-O', 'seizure-B-Disease', 'insensitive-O', 'mice-O', '.-O']
['The-O', 'binding-O', 'sites-O', 'from-O', 'seizure-B-Disease', 'sensitive-O', 'and-O', 'resistant-O', 'mice-O', 'were-O', 'equally-O', 'affected-O', 'by-O', 'treatment-O', 'with-O', 'dithiothreitol-B-Chemical', ',-O', 'trypsin-B-Chemical', 'or-O', 'heat-O', '.-O']
['Thus-O', 'it-O', 'appears-O', 'that-O', 'the-O', 'difference-O', 'between-O', 'seizure-B-Disease']
['The-O', 'role-O', 'of-O', 'p-aminophenol-B-Chemical', 'in-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease', ':-O', 'effect-O', 'of-O', 'bis(p-nitrophenyl)-I-Chemical', 'phosphate-B-Chemical', 'on-O', 'acetaminophen-B-Chemical', 'and-O', 'p-aminophenol-B-Chemical', 'nephrotoxicity-B-Disease', 'and-O', 'metabolism-O', 'in-O', 'Fischer-O', '344-O', 'rats-O', '.-O']
['Acetaminophen-B-Chemical', '(-O', 'APAP-B-Chemical', ')-O', 'produces-O', 'proximal-O', 'tubular-O', 'necrosis-B-Disease', 'in-O', 'Fischer-O', '344-O', '(-O', 'F344-O', ')-O', 'rats-O', '.-O']
['Recently-O', ',-O', 'p-aminophenol-B-Chemical', '(-O', 'PAP-B-Chemical', ')-O', 'a-O', 'known-O', 'potent-O', 'nephrotoxicant-O', ',-O', 'was-O', 'identified-O', 'as-O', 'a-O', 'metabolite-O', 'of-O', 'APAP-B-Chemical', 'in-O', 'F344-O', 'rats-O', '.-O']
['The-O', 'purpose-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'determine-O', 'if-O', 'PAP-B-Chemical', 'formation-O', 'is-O', 'a-O', 'requisite-O', 'step-O', 'in-O', 'APAP-B-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease', '.-O']
['Therefore-O', ',-O', 'the-O', 'effect-O', 'of-O', 'bis(p-nitrophenyl)-B-Chemical', 'phosphate-I-Chemical', '(-O', 'BNPP-B-Chemical', '),,-O', 'an-O', 'acylamidase-O', 'inhibitor-O', ',-O', 'on-O', 'APAP-B-Chemical', 'and-O', 'PAP-B-Chemical', 'nephrotoxicity-B-Disease', 'and-O', 'metabolism-O', 'was-O', 'determined-O', '.-O']
['BNPP-B-Chemical', '(-O', '1-O', 'to-O', '8-O', 'mM-O', ')-O', 'reduced-O', 'APAP-B-Chemical', 'deacetylation-O', 'and-O', 'covalent-O', 'binding-O', 'in-O', 'F344-O', 'renal-O', 'cortical-O', 'homogenates-O', 'in-O', 'a-O', 'concentration-O', ',-O', 'dependent-O', 'manner-O', '.-O']
['Pretreatment-O', 'of-O', 'animals-O', 'with-O', 'BNPP-B-Chemical', 'prior-O', 'to-O', 'APAP-B-Chemical', 'or-O', 'PAP-B-Chemical', 'administration-O', 'resulted-O', 'in-O', 'marked-O', 'reduction-O', 'of-O', 'APAP-B-Chemical', '(-O', '900-O', 'mg-O', '/-O', 'kg-O', ')-O', 'nephrotoxicity-B-Disease', 'but-O', 'not-O', 'PAP-B-Chemical', 'nephrotoxicity-B-Disease', '.-O']
['This-O', 'result-O', 'was-O', 'not-O', 'due-O', 'to-O', 'altered-O', 'disposition-O', 'of-O', 'either-O', 'APAP-B-Chemical', 'or-O', 'acetylated-O', 'metabolites-O', 'in-O', 'plasma-O', 'or-O', 'renal-O', 'cortical-O', 'and-O', 'hepatic-O', 'tissue-O', '.-O']
['Rather-O', ',-O', 'BNPP-B-Chemical', 'pretreatment-O', 'reduced-O', 'the-O', 'fraction-O', 'of-O', 'APAP-B-Chemical', 'excreted-O', 'as-O', 'PAP-B-Chemical', 'by-O', '64-O', 'and-O', '75-O', '%-O', 'after-O', 'APAP-B-Chemical', 'doses-O', 'of-O', '750-O', 'and-O', '900-O', 'mg-O', '/-O', 'kg-O', '.-O']
['BNPP-B-Chemical', 'did-O', 'not-O', 'alter-O', 'the-O', 'excretion-O', 'of-O', 'APAP-B-Chemical', 'or-O', 'any-O', 'of-O', 'its-O', 'non-O', ',-O', 'deacetylated-O', 'metabolites-O', 'nor-O', 'did-O', 'BNPP-B-Chemical', 'alter-O', 'excretion-O', 'of-O', 'PAP-B-Chemical', 'or-O', 'its-O', 'metabolites-O', 'after-O', 'PAP-B-Chemical', 'doses-O', 'of-O', '150-O', 'and-O', '300-O', 'mg-O', '/-O', 'kg-O', '.-O']
['Therefore-O', ',-O', 'the-O', 'BNPP-B-Chemical', ',-O', 'induced-O', 'reduction-O', 'in-O', 'APAP-B-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease', 'appears-O', 'to-O', 'be-O', 'due-O', 'to-O', 'inhibition-O', 'of-O', 'APAP-B-Chemical', 'deacetylation-O', '.-O']
['It-O', 'is-O', 'concluded-O', 'that-O', 'PAP-B-Chemical', 'formation-O', ',-O', 'in-O', 'vivo-O', ',-O', 'accounts-O', ',-O', 'at-O', 'least-O', 'in-O', 'part-O', ',-O', 'for-O', 'APAP-B-Chemical', ',-O', 'induced-O', 'renal-O', 'tubular-O', 'necrosis-B-Disease']
['Morphine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', 'in-O', 'newborn-O', 'infants-O', '.-O']
['Two-O', 'neonates-O', 'suffered-O', 'from-O', 'generalized-B-Disease', 'seizures-I-Disease', 'during-O', 'the-O', 'course-O', 'of-O', 'intravenous-O', 'morphine-B-Chemical', 'sulfate-O', 'for-O', 'post-O', ',-O', 'operative-O', 'analgesia-O', '.-O']
['They-O', 'received-O', 'morphine-B-Chemical', 'in-O', 'doses-O', 'of-O', '32-O', 'micrograms-O', '/-O', 'kg-O', '/-O', 'hr-O', 'and-O', '40-O', 'micrograms-O', '/-O', 'kg-O', '/-O', 'hr-O', 'larger-O', 'than-O', 'a-O', 'group-O', 'of-O', '10-O', 'neonates-O', 'who-O', 'received-O', '6-O', ',', '24-O', 'micrograms-O', '/-O', 'kg-O', '/-O', 'hr-O', 'and-O', 'had-O', 'no-O', 'seizures-B-Disease', '.-O']
['Plasma-O', 'concentrations-O', 'of-O', 'morphine-B-Chemical', 'in-O', 'these-O', 'neonates-O', 'was-O', 'excessive-O', '(-O', '60-O', 'and-O', '90-O', 'mg-O', '/-O', 'ml-O', ')-O', '.-O', 'Other-O', 'known-O', 'reasons-O', 'for-O', 'seizures-B-Disease', 'were-O', 'ruled-O', 'out-O', 'and-O', 'the-O', 'convulsions-B-Disease', 'stopped-O', 'a-O', 'few-O', 'hours-O', 'after-O', 'cessation-O', 'of-O', 'morphine-B-Chemical', 'and-O', 'did-O', 'not-O', 'reoccur-O', 'in-O', 'the-O', 'subsequent-O', '8-O', 'months-O', '.-O']
['It-O', 'is-O', 'suggested-O', 'that-O', 'post-O', ',-O', 'operative-O', 'intravenous-O', 'morphine-B-Chemical']
['Effect-O', 'of-O', 'vincristine-B-Chemical', 'sulfate-O', 'on-O', 'Pseudomonas-B-Disease', 'infections-I-Disease', 'in-O', 'monkeys-O', '.-O']
['In-O', 'rhesus-O', 'monkeys-O', ',-O', 'intravenous-O', 'challenge-O', 'with-O', '0-O', '.-O']
['6-O', 'x-O', '10-O', '(-O', '10-O', ')-O', 'to-O', '2-O', '.-O']
['2-O', 'x-O', '10-O', '(-O', '10-O', ')-O', 'Pseudomonas-O', 'aeruginosa-O', 'organisms-O', 'caused-O', 'acute-B-Disease', 'illness-O', 'of-O', '4-O', 'to-O', '5-O', 'days-O', 'x-O', 'duration-O', 'with-O', 'spontaneous-O', 'recovery-O', 'in-O', '13-O', 'of-O', '15-O', 'monkeys-O', ';-O', 'blood-O', 'cultures-O', 'became-O', 'negative-O', '3-O', 'to-O', '17-O', 'days-O', 'after-O', 'challenge-O', '.-O']
['Leukocytosis-B-Disease', 'was-O', 'observed-O', 'in-O', 'all-O', 'monkeys-O', '.-O']
['Intravenous-O', 'or-O', 'intratracheal-O', 'inoculation-O', 'of-O', '2-O', '.-O']
['0-O', 'to-O', '2-O', '.-O']
['5-O', 'mg-O', 'of-O', 'vincristine-B-Chemical', 'sulfate-O', 'was-O', 'followed-O', 'by-O', 'leukopenia-B-Disease', 'in-O', '4-O', 'to-O', '5-O', 'days-O', '.-O']
['Intravenous-O', 'inoculation-O', 'of-O', '4-O', '.-O']
['2-O', 'x-O', '10-O', '(-O', '10-O', ')-O', 'to-O', '7-O', '.-O']
['8-O', 'x-O', '10-O', '(-O', '10-O', ')-O', 'pyocin-O', 'type-O', '6-O', 'Pseudomonas-O', 'organisms-O', 'in-O', 'monkeys-O', 'given-O', 'vincristine-B-Chemical', 'sulfate-O', '4-O', 'days-O', 'previously-O', 'resulted-O', 'in-O', 'fatal-O', 'infection-B-Disease', 'in-O', '11-O', 'of-O', '14-O', 'monkeys-O', ',-O', 'whereas-O', 'none-O', 'of-O', 'four-O', 'receiving-O', 'Pseudomonas-O', 'alone-O', 'died-O', '.-O']
['These-O', 'studies-O', 'suggest-O', 'that-O', 'an-O', 'antimetabolite-B-Chemical', ',-O', 'induced-O', 'leukopenia-B-Disease', 'predisposes-O', 'to-O', 'severe-O', 'Pseudomonas-B-Disease', 'sepsis-B-Disease']
['Central-O', 'excitatory-O', 'actions-O', 'of-O', 'flurazepam-B-Chemical', '.-O']
['Toxic-O', 'actions-O', 'of-O', 'flurazepam-B-Chemical', '(-O', 'FZP-B-Chemical', ')-O', 'were-O', 'studied-O', 'in-O', 'cats-O', ',-O', 'mice-O', 'and-O', 'rats-O', '.-O']
['High-O', 'doses-O', 'caused-O', 'an-O', 'apparent-O', 'central-O', 'excitation-O', ',-O', 'most-O', 'clearly-O', 'seen-O', 'as-O', 'clonic-O', 'convulsions-B-Disease', ',-O', 'superimposed-O', 'on-O', 'general-O', 'depression-B-Disease', '.-O']
['Following-O', 'a-O', 'lethal-O', 'dose-O', ',-O', 'death-B-Disease', 'was-O', 'always-O', 'associated-O', 'with-O', 'convulsions-B-Disease', '.-O']
['Comparing-O', 'the-O', 'relative-O', 'sensitivity-O', 'to-O', 'central-O', 'depression-O', 'and-O', 'excitation-O', 'revealed-O', 'that-O', 'rats-O', 'were-O', 'least-O', 'likely-O', 'to-O', 'have-O', 'convulsions-B-Disease', 'at-O', 'doses-O', 'that-O', 'did-O', 'not-O', 'first-O', 'cause-O', 'loss-O', 'of-O', 'consciousness-O', ',-O', 'while-O', 'cats-O', 'most-O', 'clearly-O', 'showed-O', 'marked-O', 'central-O', 'excitatory-O', 'actions-O', '.-O']
['Signs-O', 'of-O', 'FZP-B-Chemical', 'toxocity-O', 'in-O', 'cats-O', 'included-O', 'excessive-O', 'salivation-O', ',-O', 'extreme-O', 'apprehensive-O', 'behavior-O', ',-O', 'retching-O', ',-O', 'muscle-O', 'tremors-B-Disease', 'and-O', 'convulsions-B-Disease', '.-O']
['An-O', 'interaction-O', 'between-O', 'FZP-B-Chemical', 'and-O', 'pentylenetetrazol-B-Chemical', '(-O', 'PTZ-B-Chemical', ')-O', 'was-O', 'shown-O', 'by-O', 'pretreating-O', 'mice-O', 'with-O', 'FZP-B-Chemical', 'before-O', 'PTZ-B-Chemical', 'challenge-O', '.-O']
['As-O', 'a-O', 'function-O', 'of-O', 'dose-O', ',-O', 'FZP-B-Chemical', 'first-O', 'protected-O', 'against-O', 'convulsions-B-Disease', 'and-O', 'death-B-Disease', '.-O']
['At-O', 'higher-O', 'doses-O', ',-O', 'however-O', ',-O', 'convulsions-B-Disease', 'again-O', 'emerged-O', '.-O']
['These-O', 'doses-O', 'of-O', 'FZP-B-Chemical', 'were-O', 'lower-O', 'than-O', 'those-O', 'that-O', 'would-O', 'alone-O', 'cause-O', 'convulsions-B-Disease', '.-O']
['These-O', 'results-O', 'may-O', 'be-O', 'relevant-O', 'to-O', 'the-O', 'use-O', 'of-O', 'FZP-B-Chemical', 'in-O', 'clinical-O', 'situations-O', 'in-O', 'which-O', 'there-O', 'is-O', 'increased-O', 'neural-O', 'excitability-O', ',-O', 'such-O', 'as-O', 'epilepsy-B-Disease']
['Evidence-O', 'for-O', 'cardiac-O', 'beta-O', '2-O', ',-O', 'adrenoceptors-O', 'in-O', 'man-O', '.-O']
['We-O', 'compared-O', 'the-O', 'effects-O', 'of-O', 'single-O', 'doses-O', 'of-O', '50-O', 'mg-O', 'atenolol-B-Chemical', '(-O', 'cardioselective-O', '),,-O', '40-O', 'mg-O', 'propranolol-B-Chemical', '(-O', 'nonselective-O', '),,-O', 'and-O', 'placebo-O', 'on-O', 'both-O', 'exercise-O', ',-O', 'and-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'tachycardia-B-Disease', 'in-O', 'two-O', 'experiments-O', 'involving-O', 'nine-O', 'normal-O', 'subjects-O', '.-O']
['Maximal-O', 'exercise-O', 'heart-O', 'rate-O', 'was-O', 'reduced-O', 'from-O', '187-O', '+-O', '4-O', '(-O', 'SEM-O', ')', 'after-O', 'placebo-O', 'to-O', '146-O', '+-O', '7-O', 'bpm-O', 'after-O', 'atenolol-B-Chemical', 'and-O', '138-O', '+-O', '6-O', 'bpm-O', 'after-O', 'propranolol-B-Chemical', ',-O', 'but-O', 'there-O', 'were-O', 'no-O', 'differences-O', 'between-O', 'the-O', 'drugs-O', '.-O']
['The-O', 'effects-O', 'on-O', 'isoproterenol-B-Chemical', 'tachycardia-B-Disease', 'were-O', 'determined-O', 'before-O', 'and-O', 'after-O', 'atropine-B-Chemical', '(-O', '0-O', ')-O', '.-O']
['04-O', 'mg-O', '/-O', 'kg-O', 'IV-O', ').-O', 'Isoproterenol-B-Chemical', 'sensitivity-O', 'was-O', 'determined-O', 'as-O', 'the-O', 'intravenous-O', 'dose-O', 'that-O', 'increased-O', 'heart-O', 'rate-O', 'by-O', '25-O', 'bpm-O', '(-O', 'CD25-O', ')-O', 'and-O', 'this-O', 'was-O', 'increased-O', 'from-O', '1-O', '.-O']
['8-O', '+-O', '0-O', '.-O']
['3-O', 'micrograms-O', 'after-O', 'placebo-O', 'to-O', '38-O', '.-O']
['9-O', '+-O', '8-O', '.-O']
['3-O', 'micrograms-O', 'after-O', 'propranolol-B-Chemical', 'and-O', '8-O', '.-O']
['3-O', '+-O', '1-O', '.-O']
['7-O', 'micrograms-O', 'after-O', 'atenolol-B-Chemical', '.-O']
['The-O', 'difference-O', 'in-O', 'the-O', 'effects-O', 'of-O', 'the-O', 'two-O', 'was-O', 'significant-O', '.-O']
['After-O', 'atropine-B-Chemical', 'the-O', 'CD25-O', 'was-O', 'unchanged-O', 'after-O', 'placebo-O', '(-O', '2-O', '.-O']
['3-O', '+-O', '0-O', '.-O']
['3-O', 'micrograms-O', ')-O', 'and-O', 'atenolol-B-Chemical', '(-O', '7-O', '.-O']
['7-O', '+-O', '1-O', '.-O']
['3-O', 'micrograms-O', ')-O', 'it-O', 'was-O', 'reduced-O', 'after-O', 'propranolol-B-Chemical', '(-O', '24-O', '.-O']
['8-O', '+-O', '5-O', '.-O']
['0-O', 'micrograms-O', ')-O', 'but-O', 'remained-O', 'different-O', 'from-O', 'atenolol-B-Chemical', '.-O']
['This-O', 'change-O', 'with-O', 'propranolol-B-Chemical', 'sensitivity-O', 'was-O', 'calculated-O', 'as-O', 'the-O', 'apparent-O', 'Ka-O', ',-O', 'this-O', 'was-O', 'unchanged-O', 'by-O', 'atropine-B-Chemical', '(-O', '11-O', '.-O']
['7-O', '+-O', '2-O', '.-O']
['1-O', 'and-O', '10-O', '.-O']
['1-O', '+-O', '2-O', '.-O']
['5-O', 'ml-O', '/-O', 'ng-O', ').-O', 'These-O', 'data-O', 'are-O', 'consistent-O', 'with-O', 'the-O', 'hypothesis-O', 'that-O', 'exercise-O', ',-O', 'induced-O', 'tachycardia-B-Disease', 'results-O', 'largely-O', 'from-O', 'beta-O', '1-O', ',-O', 'receptor-O', 'activation-O', 'that-O', 'is-O', 'blocked-O', 'by-O', 'both-O', 'cardioselective-O', 'and-O', 'nonselective-O', 'drugs-O', ',-O', 'whereas-O', 'isoproterenol-B-Chemical']
['Hormones-O', 'and-O', 'risk-O', 'of-O', 'breast-B-Disease', 'cancer-I-Disease', '.-O']
['This-O', 'paper-O', 'reports-O', 'the-O', 'results-O', 'of-O', 'a-O', 'study-O', 'of-O', '50-O', 'menopausal-O', 'women-O', 'receiving-O', 'hormonal-O', 'replacement-O', 'therapy-O', '.-O']
['The-O', 'majority-O', '(-O', '29-O', ')-O', 'had-O', 'surgical-O', 'menopause-B-Disease', ';-O', 'their-O', 'mean-O', 'age-O', 'was-O', '45-O', '.-O']
['7-O', 'years-O', '.-O']
['It-O', 'was-O', 'hypothesized-O', 'that-O', 'progestins-B-Chemical', 'could-O', 'equilibrate-O', 'the-O', 'effects-O', 'of-O', 'the-O', 'estrogenic-O', 'stimulation-O', 'on-O', 'the-O', 'mammary-O', 'and-O', 'endometrial-B-Disease', 'target-O', 'tissues-O', 'of-O', 'women-O', 'on-O', 'hormonal-O', 'replacement-O', 'therapy-O', '.-O']
['The-O', 'treatment-O', 'schedule-O', 'consisted-O', 'of-O', 'conjugated-O', 'estrogens-B-Chemical', '(-O', 'Premarin-B-Chemical', ')', '1-O', '.-O']
['25-O', 'mg-O', '/-O', 'day-O', 'for-O', '21-O', 'days-O', 'and-O', 'Medroxyprogesterone-B-Chemical', 'acetate-B-Chemical', '10-O', 'mg-O', '/-O', 'day-O', 'for-O', '10-O', 'days-O', 'in-O', 'each-O', 'month-O', '.-O']
['The-O', 'mean-O', 'treatment-O', 'period-O', 'was-O', '18-O', 'months-O', '.-O']
['During-O', 'the-O', 'follow-O', ',-O', 'up-O', 'period-O', ',-O', 'attention-O', 'was-O', 'paid-O', 'to-O', 'breast-O', 'modifications-O', 'as-O', 'evidenced-O', 'by-O', 'symptomatology-O', ',-O', 'physical-O', 'examination-O', ',-O', 'and-O', 'plate-O', 'thermography-O', '.-O']
['Mastodynia-B-Disease', 'was-O', 'reported-O', 'by-O', '21-O', 'patients-O', ',-O', 'and-O', 'physical-O', 'examination-O', 'revealed-O', 'a-O', 'light-O', 'increase-O', 'in-O', 'breast-O', 'firmness-O', 'in-O', '12-O', 'women-O', 'and-O', 'a-O', 'moderate-O', 'increase-O', 'in-O', 'breast-O', 'nodularity-O', 'in-O', '2-O', 'women-O', '.-O']
['Themography-O', 'confirmed-O', 'the-O', 'existence-O', 'of-O', 'an-O', 'excessive-O', 'breast-O', 'stimulation-O', 'in-O', '1-O', 'women-O', 'who-O', 'complained-O', 'of-O', 'moderate-O', 'mastodynia-B-Disease', 'and-O', 'in-O', '5-O', 'of-O', 'the-O', '7-O', 'women-O', 'who-O', 'complained-O', 'of-O', 'severe-O', 'mastodynia-B-Disease', '.-O']
['Normalization-O', 'was-O', 'obtained-O', 'by-O', 'halving-O', 'the-O', 'estrogen-B-Chemical']
['Early-O', 'infections-B-Disease', 'in-O', 'kidney-O', ',-O', 'heart-O', ',-O', 'and-O', 'liver-O', 'transplant-O', 'recipients-O', 'on-O', 'cyclosporine-B-Chemical', '.-O']
['Eighty-O', ',-O', 'one-O', 'renal-O', ',-O', 'seventeen-O', 'heart-O', ',-O', 'and-O', 'twenty-O', ',-O', 'four-O', 'liver-O', 'transplant-O', 'patients-O', 'were-O', 'followed-O', 'for-O', 'infection-O', '.-O']
['Seventeen-O', 'renal-O', 'patients-O', 'received-O', 'azathioprine-B-Chemical', '(-O', 'Aza-B-Chemical', ')-O', 'and-O', 'prednisone-B-Chemical', 'as-O', 'part-O', 'of-O', 'a-O', 'randomized-O', 'trial-O', 'of-O', 'immunosuppression-O', 'with-O', '21-O', 'cyclosporine-B-Chemical', ',-O', 'and-O', ',-O', 'prednisone-B-Chemical', ',-O', 'treated-O', 'renal-O', 'transplant-O', 'patients-O', '.-O']
['All-O', 'others-O', 'received-O', 'cyclosporine-B-Chemical', 'and-O', 'prednisone-B-Chemical', '.-O']
['The-O', 'randomized-O', 'Aza-B-Chemical', 'patients-O', 'had-O', 'more-O', 'overall-O', 'infections-B-Disease', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ')-O', 'and-O', 'more-O', 'nonviral-O', 'infections-B-Disease', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['02-O', ')-O', 'than-O', 'the-O', 'randomized-O', 'cyclosporine-B-Chemical', 'patients-O', '.-O']
['Heart-O', 'and-O', 'liver-O', 'patients-O', 'had-O', 'more-O', 'infections-B-Disease', 'than-O', 'cyclosporine-B-Chemical', 'renal-O', 'patients-O', 'but-O', 'fewer-O', 'infections-B-Disease', 'than-O', 'the-O', 'Aza-B-Chemical', 'renal-O', 'patients-O', '.-O']
['There-O', 'were-O', 'no-O', 'infectious-O', 'deaths-B-Disease', 'in-O', 'renal-O', 'transplant-O', 'patients-O', 'on-O', 'cyclosporine-B-Chemical', 'or-O', 'Aza-B-Chemical', ',-O', 'but-O', 'infection-B-Disease', 'played-O', 'a-O', 'major-O', 'role-O', 'in-O', '3-O', 'out-O', 'of-O', '6-O', 'cardiac-O', 'transplant-O', 'deaths-B-Disease', 'and-O', 'in-O', '8-O', 'out-O', 'of-O', '9-O', 'liver-O', 'transplant-O', 'deaths-B-Disease', '.-O']
['Renal-O', 'patients-O', 'on-O', 'cyclosporine-B-Chemical', 'had-O', 'the-O', 'fewest-O', 'bacteremias-B-Disease', '.-O']
['Analysis-O', 'of-O', 'site-O', 'of-O', 'infection-O', 'showed-O', 'a-O', 'preponderance-O', 'of-O', 'abdominal-O', 'infections-B-Disease', 'in-O', 'liver-O', 'patients-O', ',-O', 'intrathoracic-O', 'infections-B-Disease', 'in-O', 'heart-O', 'patients-O', ',-O', 'and-O', 'urinary-O', 'tract-O', 'infections-B-Disease', 'in-O', 'renal-O', 'patients-O', '.-O']
['Pulmonary-B-Disease', 'infections-I-Disease', 'were-O', 'less-O', 'common-O', 'in-O', 'cyclosporine-B-Chemical', ',-O', 'treated-O', 'renal-O', 'patients-O', 'than-O', 'in-O', 'Aza-B-Chemical', ',-O', 'treated-O', 'patients-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ').-O', 'Aza-O', 'patients-O', 'had-O', 'significantly-O', 'more-O', 'staphylococcal-B-Disease', 'infections-O', 'than-O', 'all-O', 'other-O', 'transplant-O', 'groups-O', '(-O', 'P-O', 'less-O', 'than-O', '0-O', '.-O']
['005-O', ')-O', 'and-O', 'systemic-O', 'fungal-O', 'infections-B-Disease', 'occurred-O', 'only-O', 'in-O', 'the-O', 'liver-O', 'transplant-O', 'group-O', '.-O']
['Cytomegalovirus-B-Disease', '(-O', 'CMV-B-Disease', ')-O', 'shedding-O', 'or-O', 'serological-O', 'rises-O', 'in-O', 'antibody-O', 'titer-O', ',-O', 'or-O', 'both-O', 'occurred-O', 'in-O', '78-O', '%-O', 'of-O', 'cyclosporine-B-Chemical', 'patients-O', 'and-O', '76-O', '%-O', 'of-O', 'Aza-B-Chemical', 'patients-O', '.-O']
['Of-O', 'the-O', 'cyclosporine-B-Chemical', 'patients-O', ',-O', '15-O', '%-O', 'had-O', 'symptoms-O', 'related-O', 'to-O', 'CMV-B-Disease', 'infection-I-Disease', '.-O']
['Serological-O', 'evidence-O', 'for-O', 'Epstein-O', 'Barr-O', 'Virus-B-Disease', 'infection-I-Disease', 'was-O', 'found-O', 'in-O', '20-O', '%-O', 'of-O', '65-O', 'cyclosporine-B-Chemical', 'patients-O', 'studied-O', '.-O']
['Three-O', 'had-O', 'associated-O', 'symptoms-O', ',-O', 'and-O', 'one-O', 'developed-O', 'a-O', 'lymphoma-B-Disease', '.-O']
['Structure-O', ',-O', 'activity-O', 'and-O', 'dose-O', ',-O', 'effect-O', 'relationships-O', 'of-O', 'the-O', 'antagonism-O', 'of-O', 'picrotoxin-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', 'by-O', 'cholecystokinin-B-Chemical', ',-O', 'fragments-O', 'and-O', 'analogues-O', 'of-O', 'cholecystokinin-B-Chemical', 'in-O', 'mice-O', '.-O']
['Intraperitoneal-O', 'administration-O', 'of-O', 'cholecystokinin-B-Chemical', 'octapeptide-O', 'sulphate-O', 'ester-O', '(-O', 'CCK-8-B-Chemical', ',-O', 'SE-O', ')', 'and-O', 'nonsulphated-O', 'cholecystokinin-B-Chemical', 'octapeptide-O', '(-O', 'CCK-8-B-Chemical', ',-O', 'NS-O', ')', 'enhanced-O', 'the-O', 'latency-O', 'of-O', 'seizures-B-Disease', 'induced-O', 'by-O', 'picrotoxin-B-Chemical', 'in-O', 'mice-O', '.-O']
['Experiments-O', 'with-O', 'N-O', ',-O', 'and-O', 'C-O', ',-O', 'terminal-O', 'fragments-O', 'revealed-O', 'that-O', 'the-O', 'C-O', ',-O', 'terminal-O', 'tetrapeptide-O', '(-O', 'CCK-B-Chemical', ',-O', '5-O', ',-O', '8-O', ')', 'was-O', 'the-O', 'active-O', 'centre-O', 'of-O', 'the-O', 'CCK-B-Chemical', 'octapeptide-O', 'molecule-O', '.-O']
['The-O', 'analogues-O', 'CCK-8-B-Chemical', ',-O', 'SE-O', 'and-O', 'CCK-8-B-Chemical', ',-O', 'NS-O', '(-O', 'dose-O', 'range-O', '0-O', '.-O']
['2-O', ',-O', '6-O', '.-O']
['4-O', 'mumol-O', '/-O', 'kg-O', ')-O', 'and-O', 'caerulein-B-Chemical', 'dose-O', 'range-O', '0-O', '.-O']
['1-O', ',-O', '0-O', '.-O']
['8-O', 'mumol-O', '/-O', 'kg-O', ')-O', 'showed-O', 'bell-O', 'shaped-O', 'dose-O', ',-O', 'effect-O', 'curves-O', ',-O', 'with-O', 'the-O', 'greatest-O', 'maximum-O', 'inhibition-O', 'for-O', 'CCK-8-B-Chemical', ',-O', 'NS-O', '.-O']
['The-O', 'peptide-O', 'CCK-B-Chemical', ',-O', '5-O', ',-O', '8-O', 'had-O', 'weak-O', 'anticonvulsant-O', 'activity-O', 'in-O', 'comparison-O', 'to-O', 'the-O', 'octapeptides-O', ',-O', '3-O', '.-O']
['2-O', 'mumol-O', '/-O', 'kg-O', 'and-O', 'larger-O', 'doses-O', 'of-O', 'the-O', 'reference-O', 'drug-O', ',-O', 'diazepam-B-Chemical', ',-O', 'totally-O', 'prevented-O', 'picrotoxin-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', 'and-O', 'mortality-O', '.-O']
['The-O', 'maximum-O', 'effect-O', 'of-O', 'the-O', 'peptides-O', 'tested-O', 'was-O', 'less-O', 'than-O', 'that-O', 'of-O', 'diazepam-B-Chemical', '.-O']
['Experiments-O', 'with-O', 'analogues-O', 'and-O', 'derivatives-O', 'of-O', 'CCK-B-Chemical', ',-O', '5-O', ',-O', '8-O', 'demonstrated-O', 'that-O', 'the-O', 'effectiveness-O', 'of-O', 'the-O', 'beta-O', 'alanyl-O', 'derivatives-O', 'of-O', 'CCK-B-Chemical', ',-O', '5-O', ',-O', '8-O', 'were-O', 'enhanced-O', 'and-O', 'that-O', 'they-O', 'were-O', 'equipotent-O', 'with-O', 'CCK-8-B-Chemical', ',-O', 'SE-O', '.-O']
['Of-O', 'the-O', 'CCK-B-Chemical', ',-O', '2-O', ',-O', '8-O', 'analogues-O', ',-O', 'Ser-B-Chemical', '(-O', 'SO3H-B-Chemical', ')-O', '7-O', ',-O', 'Ac-B-Chemical', ',-O', 'CCK-B-Chemical', ',-O', '2-O', ',-O', '8-O', ',-O', 'SE-O', 'and-O', 'Thr-B-Chemical', '(-O', 'SO3H-B-Chemical', ')-O', '7-O', ',-O', 'Ac-B-Chemical', ',-O', 'CCK-B-Chemical', ',-O', '2-O', ',-O', '8-O', ',-O', 'SE-O', 'and-O', 'Hyp-B-Chemical', '(-O', 'SO3H-B-Chemical', ')-O', 'Ac-B-Chemical', ',-O', 'CCK-B-Chemical', ',-O', '2-O', ',-O', '8-O', ',-O', 'SE-O', 'were-O', 'slightly-O', 'more-O', 'active-O', 'than-O', 'CCK-8-B-Chemical']
['Vasopressin-B-Chemical', 'as-O', 'a-O', 'possible-O', 'contributor-O', 'to-O', 'hypertension-B-Disease', '.-O']
['The-O', 'role-O', 'of-O', 'vasopressin-B-Chemical', 'as-O', 'a-O', 'pressor-O', 'agent-O', 'to-O', 'the-O', 'hypertensive-B-Disease', 'process-O', 'was-O', 'examined-O', '.-O']
['Vasopressin-B-Chemical', 'plays-O', 'a-O', 'major-O', 'role-O', 'in-O', 'the-O', 'pathogenesis-O', 'of-O', 'DOCA-B-Chemical', ',-O', 'salt-B-Chemical', 'hypertension-B-Disease', ',-O', 'since-O', 'the-O', 'elevation-O', 'of-O', 'blood-O', 'pressure-O', 'was-O', 'not-O', 'substantial-O', 'in-O', 'the-O', 'rats-O', 'with-O', 'lithium-B-Chemical', ',-O', 'treated-O', 'diabetes-B-Disease', 'insipidus-I-Disease', 'after-O', 'DOCA-B-Chemical', ',-O', 'salt-B-Chemical', 'treatment-O', '.-O']
['Administration-O', 'of-O', 'DDAVP-B-Chemical', 'which-O', 'has-O', 'antidiuretic-O', 'action-O', 'but-O', 'minimal-O', 'vasopressor-O', 'effect-O', 'failed-O', 'to-O', 'increase-O', 'blood-O', 'pressure-O', 'to-O', 'the-O', 'levels-O', 'observed-O', 'after-O', 'administration-O', 'of-O', 'AVP-B-Chemical', '.-O']
['Furthermore-O', ',-O', 'the-O', 'pressor-O', 'action-O', 'of-O', 'vasopressin-B-Chemical', 'appears-O', 'to-O', 'be-O', 'important-O', 'in-O', 'the-O', 'development-O', 'of-O', 'this-O', 'model-O', 'of-O', 'hypertension-B-Disease', ',-O', 'since-O', 'the-O', 'enhanced-O', 'pressor-O', 'responsiveness-O', 'to-O', 'the-O', 'hormone-O', 'was-O', 'observed-O', 'in-O', 'the-O', 'initial-O', 'stage-O', 'of-O', 'hypertension-B-Disease', '.-O']
['Increased-O', 'secretion-O', 'of-O', 'vasopressin-B-Chemical', 'from-O', 'neurohypophysis-O', 'also-O', 'promotes-O', 'the-O', 'function-O', 'of-O', 'the-O', 'hormone-O', 'as-O', 'a-O', 'pathogenetic-O', 'factor-O', 'in-O', 'hypertension-B-Disease', '.-O']
['An-O', 'unproportional-O', 'release-O', 'of-O', 'vasopressin-B-Chemical', 'compared-O', 'to-O', 'plasma-O', 'osmolality-O', 'may-O', 'be-O', 'induced-O', 'by-O', 'the-O', 'absence-O', 'of-O', 'an-O', 'adjusting-O', 'control-O', 'of-O', 'angiotensin-B-Chemical', 'II-I-Chemical', 'forming-O', 'and-O', 'receptor-O', 'binding-O', 'capacity-O', 'for-O', 'sodium-B-Chemical', 'balance-O', 'in-O', 'the-O', 'brain-O', '.-O']
['However-O', ',-O', 'the-O', 'role-O', 'of-O', 'vasopressin-B-Chemical', 'remains-O', 'to-O', 'be-O', 'determined-O', 'in-O', 'human-O', 'essential-O', 'hypertension-B-Disease']
['Toxic-B-Disease', 'hepatitis-I-Disease', 'induced-O', 'by-O', 'disulfiram-B-Chemical', 'in-O', 'a-O', 'non-O', ',-O', 'alcoholic-O', '.-O']
['A-O', 'reversible-O', 'toxic-O', 'liver-B-Disease', 'damage-I-Disease', 'was-O', 'observed-O', 'in-O', 'a-O', 'non-O', ',-O', 'alcoholic-O', 'woman-O', 'treated-O', 'with-O', 'disulfiram-B-Chemical']
['Atrial-B-Disease', 'thrombosis-I-Disease', 'involving-O', 'the-O', 'heart-O', 'of-O', 'F-O', ',', '344-O', 'rats-O', 'ingesting-O', 'quinacrine-B-Chemical', 'hydrochloride-I-Chemical', '.-O']
['Quinacrine-B-Chemical', 'hydrochloride-I-Chemical', 'is-O', 'toxic-O', 'for-O', 'the-O', 'heart-O', 'of-O', 'F-O', ',-O', '344-O', 'rats-O', '.-O']
['Rats-O', 'treated-O', 'with-O', '500-O', 'ppm-O', 'quinacrine-B-Chemical', 'hydrochloride-I-Chemical', 'in-O', 'the-O', 'diet-O', 'all-O', 'developed-O', 'a-O', 'high-O', 'incidence-O', 'of-O', 'left-O', 'atrial-O', 'thrombosis-B-Disease', '.-O']
['The-O', 'lesion-O', 'was-O', 'associated-O', 'with-O', 'cardiac-O', 'hypertrophy-I-Disease', 'and-O', 'dilatation-O', 'and-O', 'focal-O', 'myocardial-O', 'degeneration-I-Disease', '.-O']
['Rats-O', 'died-O', 'from-O', 'cardiac-B-Disease', 'hypertrophy-I-Disease', 'with-O', 'severe-O', 'acute-O', 'and-O', 'chronic-O', 'congestion-O', 'of-O', 'the-O', 'lungs-O', ',-O', 'liver-O', ',-O', 'and-O', 'other-O', 'organs-O', '.-O']
['Seventy-O', 'percent-O', 'of-O', 'rats-O', 'given-O', '250-O', 'ppm-O', 'quinacrine-B-Chemical', 'hydrochloride-I-Chemical', 'and-O', '1-O', ',', '000-O', 'ppm-O', 'sodium-B-Chemical', 'nitrite-I-Chemical', 'simultaneously-O', 'in-O', 'the-O', 'diet-O', 'had-O', 'thrombosis-B-Disease', 'of-O', 'the-O', 'atria-O', 'of-O', 'the-O', 'heart-O', ',-O', 'while-O', 'untreated-O', 'control-O', 'rats-O', 'in-O', 'this-O', 'laboratory-O', 'did-O', 'not-O', 'have-O', 'atrial-B-Disease', 'thrombosis-B-Disease', '.-O']
['Sodium-B-Chemical', 'nitrite-I-Chemical', 'in-O', 'combination-O', 'with-O', 'quinacrine-B-Chemical', 'hydrochloride-I-Chemical']
['Alternating-O', 'sinus-B-Disease', 'rhythm-O', 'and-O', 'intermittent-O', 'sinoatrial-B-Disease', 'block-I-Disease', 'induced-O', 'by-O', 'propranolol-B-Chemical', '.-O']
['Alternating-O', 'sinus-B-Disease', 'rhythm-O', 'and-O', 'intermittent-O', 'sinoatrial-B-Disease', '(S-A)-O', 'block-I-Disease', 'was-O', 'observed-O', 'in-O', 'a-O', '57-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', ',-O', 'under-O', 'treatment-O', 'for-O', 'angina-B-Disease', 'with-O', '80-O', 'mg-O', 'propranolol-B-Chemical', 'daily-O', '.-O']
['The-O', 'electrocardiogram-O', 'showed-O', 'alternation-O', 'of-O', 'long-O', 'and-O', 'short-O', 'P-O', ',-O', 'P-O', 'intervals-O', 'and-O', 'occasional-O', 'pauses-O', '.-O']
['These-O', 'pauses-O', 'were-O', 'always-O', 'preceded-O', 'by-O', 'the-O', 'short-O', 'P-O', ',-O', 'P-O', 'intervals-O', 'and-O', 'were-O', 'usually-O', 'followed-O', 'by-O', 'one-O', 'or-O', 'two-O', 'P-O', ',-O', 'P-O', 'intervals-O', 'of-O', '0-O', '.-O']
['92-O', ',-O', '0-O', '.-O']
['95-O', 's-O', 'representing-O', 'the-O', 'basic-O', 'sinus-B-Disease', 'cycle-O', '.-O']
['Following-O', 'these-O', 'basic-O', 'sinus-B-Disease', 'cycles-O', ',-O', 'alternating-O', 'rhythm-O', 'started-O', 'with-O', 'the-O', 'longer-O', 'P-O', ',-O', 'P-O', 'interval-O', '.-O']
['The-O', 'long-O', 'P-O', ',-O', 'P-O', 'intervals-O', 'ranged-O', 'between-O', '1-O', '.-O']
['04-O', ',-O', '1-O', '.-O']
['12-O', 's-O', 'and-O', 'the-O', 'short-O', 'P-O', ',-O', 'P-O', 'intervals-O', 'between-O', '0-O', '.-O']
['80-O', ',-O', '0-O', '.-O']
['84-O', 's-O', ',-O', 'respectively-O', '.-O']
['The-O', 'duration-O', 'of-O', 'the-O', 'pauses-O', 'were-O', 'equal-O', 'or-O', 'almost-O', 'equal-O', 'to-O', 'one-O', 'short-O', 'plus-O', 'one-O', 'long-O', 'P-O', ',-O', 'P-O', 'interval-O', 'or-O', 'to-O', 'twice-O', 'the-O', 'basic-O', 'sinus-O', 'cycle-O', '.-O']
['In-O', 'one-O', 'recording-O', 'a-O', 'short-O', 'period-O', 'of-O', 'regular-O', 'sinus-B-Disease', 'rhythm-O', 'with-O', 'intermittent-O', '2-O', '/-O', '1-O', 'S-A-B-Disease', 'block-I-Disease', 'was-O', 'observed-O', '.-O']
['This-O', 'short-O', 'period-O', 'of-O', 'sinus-B-Disease', 'rhythm-O', 'was-O', 'interrupted-O', 'by-O', 'sudden-O', 'prolongation-O', 'of-O', 'the-O', 'P-O', ',-O', 'P-O', 'interval-O', 'starting-O', 'the-O', 'alternative-O', 'rhythm-O', '.-O']
['There-O', 'were-O', 'small-O', 'changes-O', 'in-O', 'the-O', 'shape-O', 'of-O', 'the-O', 'P-O', 'waves-O', 'and-O', 'P-O', ',-O', 'R-O', 'intervals-O', '.-O']
['S-O', ',-O', 'A-O', 'conduction-O', 'through-O', 'two-O', 'pathways-O', ',-O', 'the-O', 'first-O', 'with-O', '2-O', '/-O', '1-O', 'block-O', 'the-O', 'second-O', 'having-O', '0-O', '.-O']
['12-O', ',-O', '0-O', '.-O']
['14-O', 's-O', 'longer-O', 'conduction-O', 'time-O', 'and-O', 'with-O', 'occasional-O', '2-O', '/-O', '1-O', 'block-O', 'was-O', 'proposed-O', 'for-O', 'the-O', 'explanation-O', 'of-O', 'the-O', 'alternating-O', 'P-O', ',-O', 'P-O', 'interval-O', 'and-O', 'other-O', 'electrocardiographic-O', 'features-O', 'seen-O', '.-O']
['Atropine-B-Chemical', '1-O', 'mg-O', 'given-O', 'intravenously-O', 'resulted-O', 'in-O', 'shortening-O', 'of-O', 'all-O', 'P-O', ',-O', 'P-O', 'intervals-O', 'without-O', 'changing-O', 'the-O', 'rhythm-O', '.-O']
['The-O', 'abnormal-B-Disease', 'rhythm-I-Disease', 'disappeared-O', 'with-O', 'the-O', 'withdrawal-O', 'of-O', 'propranolol-B-Chemical', 'and-O', 'when-O', 'the-O', 'drug-O', 'was-O', 'restarted-O', 'a-O', '2-O', '/-O', '1-O', 'S-A-O', 'block-O', 'was-O', 'seen-O', '.-O']
['This-O', 'was-O', 'accepted-O', 'as-O', 'evidence-O', 'for-O', 'propranolol-B-Chemical', 'being-O', 'the-O', 'cause-O', 'of-O', 'this-O', 'conduction-O', 'disorder-B-Disease']
['Antitumor-O', 'effect-O', ',-O', 'cardiotoxicity-B-Disease', ',-O', 'and-O', 'nephrotoxicity-B-Disease', 'of-O', 'doxorubicin-B-Chemical', 'in-O', 'the-O', 'IgM-O', 'solid-O', 'immunocytoma-O', ',-O', 'bearing-O', 'LOU-O', '/', 'M-O', '/', 'WSL-O', 'rat-O', '.-O']
['Antitumor-O', 'activity-O', ',-O', 'cardiotoxicity-B-Disease', ',-O', 'and-O', 'nephrotoxicity-B-Disease', 'induced-O', 'by-O', 'doxorubicin-B-Chemical', 'were-O', 'studied-O', 'in-O', 'LOU-O', '/', 'M-O', '/', 'WSL-O', 'inbred-O', 'rats-O', 'each-O', 'bearing-O', 'a-O', 'transplantable-O', 'solid-O', 'IgM-O', 'immunocytoma-O', '.-O']
['Animals-O', 'with-O', 'a-O', 'tumor-B-Disease', '(-O', 'diameter-O', ',-O', '15-O', '.-O']
['8-O', '+-O', '3-O', '.-O']
['3-O', 'mm-O', ')-O', 'were-O', 'treated-O', 'with-O', 'iv-O', 'injections-O', 'of-O', 'doxorubicin-B-Chemical', 'on-O', '5-O', 'consecutive-O', 'days-O', ',-O', 'followed-O', 'by-O', '1-O', 'weekly-O', 'injection-O', 'for-O', '7-O', 'weeks-O', '(-O', 'dose-O', 'range-O', ',-O', '0-O', '.-O']
['015-O', ',-O', '4-O', '.-O']
['0-O', 'mg-O', '/-O', 'kg-O', 'body-O', 'wt-O', ')-O', '.-O', 'Tumor-B-Disease', 'regression-O', 'was-O', 'observed-O', 'with-O', '0-O', '.-O']
['5-O', 'mg-O', 'doxorubicin-B-Chemical', '/-O', 'kg-O', '.-O']
['Complete-O', 'disappearance-O', 'of-O', 'the-O', 'tumor-B-Disease', 'was-O', 'induced-O', 'with-O', '1-O', '.-O']
['0-O', 'mg-O', 'doxorubicin-B-Chemical', '/-O', 'kg-O', '.-O']
['Histologic-O', 'evidence-O', 'of-O', 'cardiotoxicity-B-Disease', 'scored-O', 'as-O', 'grade-O', 'III-O', 'was-O', 'only-O', 'observed-O', 'at-O', 'a-O', 'dose-O', 'of-O', '1-O', '.-O']
['0-O', 'mg-O', 'doxorubicin-B-Chemical', '/-O', 'kg-O', '.-O']
['Light-O', 'microscopic-O', 'evidence-O', 'of-O', 'renal-B-Disease', 'damage-I-Disease', 'was-O', 'seen-O', 'above-O', 'a-O', 'dose-O', 'of-O', '0-O', '.-O']
['5-O', 'mg-O', 'doxorubicin-B-Chemical', '/-O', 'kg-O', ',-O', 'which-O', 'resulted-O', 'in-O', 'albuminuria-B-Disease', 'and-O', 'very-O', 'low-O', 'serum-O', 'albumin-O', 'levels-O', '.-O']
['In-O', 'the-O', 'group-O', 'that-O', 'received-O', '1-O', '.-O']
['0-O', 'mg-O', 'doxorubicin-B-Chemical', '/-O', 'kg-O', ',-O', 'the-O', 'serum-O', 'albumin-B-Chemical', 'level-O', 'decreased-O', 'from-O', '33-O', '.-O']
['6-O', '+-O', '4-O', '.-O']
['1-O', 'to-O', '1-O', '.-O']
['5-O', '+-O', '0-O', '.-O']
['5-O', 'g-O', '/-O', 'liter-O', '.-O']
['Ascites-B-Disease', 'and-O', 'hydrothorax-B-Disease', 'were-O', 'observed-O', 'simultaneously-O', '.-O']
['The-O', 'same-O', 'experiments-O', 'were-O', 'performed-O', 'with-O', 'non-O', ',-O', 'tumor-B-Disease', ',-O', 'bearing-O', 'rats-O', ',-O', 'in-O', 'which-O', 'no-O', 'major-O', 'differences-O', 'were-O', 'observed-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'antitumor-O', 'activity-O', ',-O', 'cardiotoxicity-B-Disease', ',-O', 'and-O', 'nephrotoxicity-B-Disease', 'were-O', 'studied-O', 'simultaneously-O', 'in-O', 'the-O', 'same-O', 'LOU-O', '/', 'M-O', '/', 'WSL-O', 'rat-O', '.-O']
['Albuminuria-B-Disease', 'due-O', 'to-O', 'renal-O', 'damage-I-Disease', 'led-O', 'to-O', 'extremely-O', 'low-O', 'serum-O', 'albumin-O', 'levels-O', ',-O', 'so-O', 'ascites-B-Disease', 'and-O', 'hydrothorax-B-Disease', 'were-O', 'not-O', 'necessarily-O', 'a-O', 'consequence-O', 'of-O', 'the-O', 'observed-O', 'cardiomyopathy-B-Disease']
['Intraoperative-O', 'bradycardia-B-Disease', 'and-O', 'hypotension-B-Disease', 'associated-O', 'with-O', 'timolol-B-Chemical', 'and-O', 'pilocarpine-B-Chemical', 'eye-O', 'drops-O', '.-O']
['A-O', '69-O', ',-O', 'yr-O', ',-O', 'old-O', 'man-O', ',-O', 'who-O', 'was-O', 'concurrently-O', 'being-O', 'treated-O', 'with-O', 'pilocarpine-B-Chemical', 'nitrate-O', 'and-O', 'timolol-B-Chemical', 'maleate-I-Chemical', 'eye-O', 'drops-O', ',-O', 'developed-O', 'a-O', 'bradycardia-B-Disease', 'and-O', 'became-O', 'hypotensive-B-Disease', 'during-O', 'halothane-B-Chemical', 'anaesthesia-O', '.-O']
['Both-O', 'timolol-B-Chemical', 'and-O', 'pilocarpine-B-Chemical', 'were-O', 'subsequently-O', 'identified-O', 'in-O', 'a-O', '24-O', ',-O', 'h-O', 'collection-O', 'of-O', 'urine-O', '.-O']
['Timolol-B-Chemical', '(-O', 'but-O', 'not-O', 'pilocarpine-B-Chemical', ')-O', 'was-O', 'detected-O', 'in-O', 'a-O', 'sample-O', 'of-O', 'plasma-O', 'removed-O', 'during-O', 'surgery-O', ';-O', 'the-O', 'plasma-O', 'concentration-O', 'of-O', 'timolol-B-Chemical', '(-O', '2-O', '.-O']
['6-O', 'ng-O', 'ml-O', ',-O', '1-O', ')-O', 'was-O', 'consistent-O', 'with-O', 'partial-O', 'beta-O', ',-O', 'adrenoceptor-O', 'blockade-O', '.-O']
['It-O', 'is-O', 'postulated-O', 'that-O', 'this-O', 'action-O', 'may-O', 'have-O', 'been-O', 'enhanced-O', 'during-O', 'halothane-B-Chemical', 'anaesthesia-O', 'with-O', 'resultant-O', 'bradycardia-B-Disease', 'and-O', 'hypotension-B-Disease', '.-O']
['pilocarpine-B-Chemical']
['Succinylcholine-B-Chemical', 'apnoea-B-Disease', ':-O', 'attempted-O', 'reversal-O', 'with-O', 'anticholinesterases-B-Chemical', '.-O']
['Anticholinesterases-B-Chemical', 'were-O', 'administered-O', 'in-O', 'an-O', 'attempt-O', 'to-O', 'antagonize-O', 'prolonged-O', 'neuromuscular-B-Disease', 'blockade-O', 'following-O', 'the-O', 'administration-O', 'of-O', 'succinylcholine-B-Chemical', 'in-O', 'a-O', 'patient-O', 'later-O', 'found-O', 'to-O', 'be-O', 'homozygous-O', 'for-O', 'atypical-O', 'plasma-O', 'cholinesterase-B-Chemical', '.-O']
['Edrophonium-B-Chemical', '10-O', 'mg-O', ',-O', 'given-O', '74-O', 'min-O', 'after-O', 'succinylcholine-B-Chemical', ',-O', 'when-O', 'train-O', ',-O', 'of-O', ',-O', 'four-O', 'stimulation-O', 'was-O', 'characteristic-O', 'of-O', 'phase-O', 'II-O', 'block-O', ',-O', 'produced-O', 'partial-O', 'antagonism-O', 'which-O', 'was-O', 'not-O', 'sustained-O', '.-O']
['Repeated-O', 'doses-O', 'of-O', 'edrophonium-B-Chemical', 'to-O', '70-O', 'mg-O', 'and-O', 'neostigmine-B-Chemical', 'to-O', '2-O', '.-O']
['5-O', 'mg-O', 'did-O', 'not-O', 'antagonize-O', 'or-O', 'augment-O', 'the-O', 'block-B-Disease', '.-O']
['Spontaneous-O', 'respiration-O', 'recommenced-O', '200-O', 'min-O', 'after-O', 'succinylcholine-B-Chemical', 'administration-O', '.-O']
['It-O', 'is-O', 'concluded-O', 'that-O', 'anticholinesterases-O', 'are-O', 'only-O', 'partially-O', 'effective-O', 'in-O', 'restoring-O', 'neuromuscular-O', 'function-O', 'in-O', 'succinylcholine-B-Chemical', 'apnoea-B-Disease']
['Effect-O', 'of-O', 'doxorubicin-B-Chemical', 'on-O', '[omega-I-131]heptadecanoic-B-Chemical', 'acid-O', 'myocardial-O', 'scintigraphy-O', 'and-O', 'echocardiography-O', 'in-O', 'dogs-O', '.-O']
['The-O', 'effects-O', 'of-O', 'serial-O', 'treatment-O', 'with-O', 'doxorubicin-B-Chemical', 'on-O', 'dynamic-O', 'myocardial-O', 'scintigraphy-O', 'with-O', '[omega-I-131]heptadecanoic-B-Chemical', 'acid-O', '(-O', 'I-131-B-Chemical', 'HA-O', '),', 'and-O', 'on-O', 'global-O', 'left-O', 'ventricular-O', 'function-O', 'determined-O', 'echocardiographically-O', ',-O', 'were-O', 'studied-O', 'in-O', 'a-O', 'group-O', 'of-O', 'nine-O', 'mongrel-O', 'dogs-O', '.-O']
['Total-O', 'extractable-O', 'myocardial-O', 'lipid-O', 'was-O', 'compared-O', 'postmortem-O', 'between-O', 'a-O', 'group-O', 'of-O', 'control-O', 'dogs-O', 'and-O', 'doxorubicin-B-Chemical', ',-O', 'treated-O', 'dogs-O', '.-O']
['A-O', 'significant-O', 'and-O', 'then-O', 'progressive-O', 'fall-O', 'in-O', 'global-O', 'LV-O', 'function-O', 'was-O', 'observed-O', 'at-O', 'a-O', 'cumulative-O', 'doxorubicin-B-Chemical', 'dose-O', 'of-O', '4-O', 'mg-O', '/-O', 'kg-O', '.-O']
['A-O', 'significant-O', 'increase-O', 'in-O', 'the-O', 'myocardial-O', 't1-O', '/-O', '2-O', 'of-O', 'the-O', 'I-131-B-Chemical', 'HA-O', 'was-O', 'observed-O', 'only-O', 'at-O', 'a-O', 'higher-O', 'cumulative-O', 'dose-O', ',-O', '10-O', 'mg-O', '/-O', 'kg-O', '.-O']
['No-O', 'significant-O', 'alteration-O', 'in-O', 'total-O', 'extractable-O', 'myocardial-O', 'lipids-O', 'was-O', 'observed-O', 'between-O', 'control-O', 'dogs-O', 'and-O', 'those-O', 'treated-O', 'with-O', 'doxorubicin-B-Chemical', '.-O']
['Our-O', 'findings-O', 'suggest-O', 'that-O', 'the-O', 'changes-O', 'leading-O', 'to-O', 'an-O', 'alteration-O', 'of-O', 'myocardial-O', 'dynamic-O', 'imaging-O', 'with-O', 'I-131-B-Chemical', 'HA-O', 'are-O', 'not-O', 'the-O', 'initiating-O', 'factor-O', 'in-O', 'doxorubicin-B-Chemical', 'cardiotoxicity-B-Disease']
['Hemodynamics-O', 'and-O', 'myocardial-O', 'metabolism-O', 'under-O', 'deliberate-O', 'hypotension-B-Disease', '.-O']
['An-O', 'experimental-O', 'study-O', 'in-O', 'dogs-O', '.-O']
['Coronary-O', 'blood-O', 'flow-O', ',-O', 'cardiac-O', 'work-O', 'and-O', 'metabolism-O', 'were-O', 'studied-O', 'in-O', 'dogs-O', 'under-O', 'sodium-B-Chemical', 'nitroprusside-I-Chemical', '(-O', 'SNP-B-Chemical', ')-O', 'and-O', 'trimetaphan-B-Chemical', '(-O', 'TMP-B-Chemical', ')-O', 'deliberate-O', 'hypotension-B-Disease', '(-O', '20-O', '%-O', 'and-O', '40-O', '%-O', 'mean-O', 'pressure-O', 'decrease-O', 'from-O', 'baseline-O', ').-O', 'Regarding-O', 'the-O', 'effects-O', 'of-O', 'drug-O', ',-O', 'induced-O', 'hypotension-B-Disease', 'on-O', 'coronary-O', 'blood-O', 'flow-O', ',-O', 'aortic-O', 'and-O', 'coronary-O', 'sinus-O', 'metabolic-O', 'data-O', '(-O', 'pH-O', ',-O', 'pO2-O', ',-O', 'pCO2-O', ')-O', 'we-O', 'could-O', 'confirm-O', 'that-O', 'nitroprusside-B-Chemical', 'hypotension-B-Disease', 'could-O', 'be-O', 'safely-O', 'used-O', 'to-O', '30-O', '%-O', 'mean-O', 'blood-O', 'pressure-O', 'decrease-O', 'from-O', 'control-O', ',-O', 'trimetaphan-B-Chemical', 'hypotension-B-Disease', 'to-O', '20-O', '%-O', 'mean-O', 'blood-O', 'pressure-O', 'decrease-O', '.-O']
['Cardiac-O', 'work-O', 'was-O', 'significantly-O', 'reduced-O', 'during-O', 'SNP-B-Chemical', 'hypotension-B-Disease', '.-O']
['Myocardial-O', 'O2-B-Chemical', 'consumption-O', 'and-O', 'O2-B-Chemical']
['Evidence-O', 'for-O', 'a-O', 'selective-O', 'brain-O', 'noradrenergic-O', 'involvement-O', 'in-O', 'the-O', 'locomotor-O', 'stimulant-O', 'effects-O', 'of-O', 'amphetamine-B-Chemical', 'in-O', 'the-O', 'rat-O', '.-O']
['Male-O', 'rats-O', 'received-O', 'the-O', 'noradrenaline-B-Chemical', 'neurotoxin-O', 'DSP4-B-Chemical', '(-O', '50-O', 'mg-O', '/-O', 'kg-O', ')-O', '7-O', 'days-O', 'prior-O', 'to-O', 'injection-O', 'of-O', 'D-amphetamine-B-Chemical', '(-O', '10-O', 'or-O', '40-O', 'mumol-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', ').-O', 'The-O', 'hyperactivity-B-Disease', 'induced-O', 'by-O', 'D-amphetamine-B-Chemical', '(-O', '10-O', 'mumol-O', '/-O', 'kg-O', ')-O', 'was-O', 'significantly-O', 'reduced-O', 'by-O', 'DSP4-B-Chemical', 'pretreatment-O', '.-O']
['However-O', ',-O', 'the-O', 'increased-O', 'rearings-O', 'and-O', 'the-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'stereotypies-B-Disease', 'were-O', 'not-O', 'blocked-O', 'by-O', 'pretreatment-O', 'with-O', 'DSP4-B-Chemical', '.-O']
['The-O', 'reduction-O', 'of-O', 'amphetamine-B-Chemical', 'hyperactivity-B-Disease', 'induced-O', 'by-O', 'DSP4-B-Chemical', 'was-O', 'blocked-O', 'by-O', 'pretreatment-O', 'with-O', 'the-O', 'noradrenaline-B-Chemical', ',-O', 'uptake-O', 'blocking-O', 'agent-O', ',-O', 'desipramine-B-Chemical', ',-O', 'which-O', 'prevents-O', 'the-O', 'neurotoxic-O', 'action-O', 'of-O', 'DSP4-B-Chemical', '.-O']
['The-O', 'present-O', 'results-O', 'suggest-O', 'a-O', 'selective-O', 'involvement-O', 'of-O', 'central-O', 'noradrenergic-O', 'neurones-O', 'in-O', 'the-O', 'locomotor-O', 'stimulant-O', 'effect-O', 'of-O', 'amphetamine-B-Chemical']
['Accelerated-O', 'junctional-O', 'rhythms-B-Disease', 'during-O', 'oral-O', 'verapamil-B-Chemical', 'therapy-O', '.-O']
['This-O', 'study-O', 'examined-O', 'the-O', 'frequency-O', 'of-O', 'atrioventricular-B-Disease', '(-O', 'AV-O', ')-O', 'dissociation-O', 'and-O', 'accelerated-O', 'junctional-O', 'rhythms-O', 'in-O', '59-O', 'patients-O', 'receiving-O', 'oral-O', 'verapamil-B-Chemical', '.-O']
['Accelerated-O', 'junctional-O', 'rhythms-O', 'and-O', 'AV-B-Disease', 'dissociation-O', 'were-O', 'frequent-O', 'in-O', 'patients-O', 'with-O', 'supraventricular-B-Disease', 'tachyarrhythmias-I-Disease', ',-O', 'particularly-O', 'AV-B-Disease', 'nodal-O', 'reentry-O', '.-O']
['Verapamil-B-Chemical', 'administration-O', 'to-O', 'these-O', 'patients-O', 'led-O', 'to-O', 'an-O', 'asymptomatic-O', 'increase-O', 'in-O', 'activity-O', 'of-O', 'these-O', 'junctional-O', 'pacemakers-O', '.-O']
['In-O', 'patients-O', 'with-O', 'various-O', 'chest-B-Disease', 'pain-I-Disease', 'syndromes-O', ',-O', 'verapamil-B-Chemical']
['Treatment-O', 'of-O', 'ovarian-B-Disease', 'cancer-I-Disease', 'with-O', 'a-O', 'combination-O', 'of-O', 'cis-platinum-B-Chemical', ',-O', 'adriamycin-B-Chemical', ',-O', 'cyclophosphamide-B-Chemical', 'and-O', 'hexamethylmelamine-B-Chemical', '.-O']
['During-O', 'the-O', 'last-O', '2-O', '1-O', '/-O', '2-O', 'years-O', ',-O', '38-O', 'patients-O', 'with-O', 'ovarian-B-Disease', 'cancer-I-Disease', 'were-O', 'treated-O', 'with-O', 'a-O', 'combination-O', 'of-O', 'cisplatinum-B-Chemical', '(-O', 'CPDD-O', ')-O', '50-O', 'mg-O', '/-O', 'm2-O', ',-O', 'adriamycin-B-Chemical', ',-O', '30-O', 'mg-O', '/-O', 'm2-O', ',-O', 'cyclophosphamide-B-Chemical', ',-O', '300-O', 'mg-O', '/-O', 'm2-O', ',-O', 'on-O', 'day-O', '1-O', ';-O', 'and-O', 'hexamethylmelamine-B-Chemical', '(-O', 'HMM-O', ')-O', '6-O', 'mg-O', '/-O', 'kg-O', 'daily-O', ',-O', 'for-O', '14-O', 'days-O', '.-O']
['Each-O', 'course-O', 'was-O', 'repeated-O', 'monthly-O', '.-O']
['2-O', 'patients-O', 'had-O', 'stage-O', 'II-O', ',-O', '14-O', 'stage-O', 'III-O', 'and-O', '22-O', 'stage-O', 'IV-O', 'disease-B-Disease', '.-O']
['14-O', 'of-O', 'the-O', '38-O', 'patients-O', 'were-O', 'previously-O', 'treated-O', 'with-O', 'chemotherapy-O', ',-O', '1-O', 'with-O', 'radiation-O', ',-O', '6-O', 'with-O', 'both-O', 'chemotherapy-O', 'and-O', 'radiation-O', ',-O', 'and-O', '17-O', 'did-O', 'not-O', 'have-O', 'any-O', 'treatment-O', 'before-O', 'CPDD-B-Chemical', 'combination-O', '.-O']
['31-O', 'of-O', 'the-O', '38-O', 'cases-O', '(-O', '81-O', '.-O']
['5-O', ')-O', 'demonstrated-O', 'objective-O', 'responses-O', 'lasting-O', 'for-O', '2-O', 'months-O', 'or-O', 'more-O', '.-O']
['These-O', 'responses-O', 'were-O', 'partial-O', 'in-O', '19-O', 'and-O', 'complete-O', 'in-O', '12-O', 'cases-O', '.-O']
['Hematologic-B-Disease', 'toxicity-I-Disease', 'was-O', 'moderate-O', 'and-O', 'with-O', 'reversible-O', 'anemia-B-Disease', 'developing-O', 'in-O', '71-O', '%-O', 'of-O', 'patients-O', '.-O']
['Gastrointestinal-B-Disease', 'side-O', 'effects-O', 'from-O', 'CPDD-B-Chemical', 'were-O', 'universal-O', '.-O']
['HMM-O', 'gastrointestinal-B-Disease', 'toxicity-I-Disease', 'necessitated-O', 'discontinuation-O', 'of-O', 'the-O', 'drug-O', 'in-O', '5-O', 'patients-O', '.-O']
['Severe-O', 'nephrotoxicity-B-Disease']
['Nontraumatic-O', 'dissecting-O', 'aneurysm-I-Disease', 'of-O', 'the-O', 'basilar-O', 'artery-O', '.-O']
['A-O', 'case-O', 'of-O', 'nontraumatic-O', 'dissecting-O', 'aneurysm-B-Disease', 'of-O', 'the-O', 'basilar-O', 'artery-O', 'in-O', 'association-O', 'with-O', 'hypertension-B-Disease', ',-O', 'smoke-O', ',-O', 'and-O', 'oral-B-Chemical', 'contraceptives-I-Chemical', 'is-O', 'reported-O', 'in-O', 'a-O', 'young-O', 'female-O', 'patient-O', 'with-O', 'a-O', 'locked-in-O', 'syndrome-O']
['Propylthiouracil-B-Chemical', ',-O', 'induced-O', 'hepatic-B-Disease', 'damage-I-Disease', '.-O']
['Two-O', 'cases-O', 'of-O', 'propylthiouracil-B-Chemical', ',-O', 'induced-O', 'liver-B-Disease', 'damage-I-Disease', 'have-O', 'been-O', 'observed-O', '.-O']
['The-O', 'first-O', 'case-O', 'is-O', 'of-O', 'an-O', 'acute-O', 'type-O', 'of-O', 'damage-O', ',-O', 'proven-O', 'by-O', 'rechallenge-O', ';-O', 'the-O', 'second-O', 'presents-O', 'a-O', 'clinical-O', 'and-O', 'histologic-O', 'picture-O', 'resembling-O', 'chronic-B-Disease', 'active-I-Disease', 'hepatitis-I-Disease']
['Studies-O', 'on-O', 'the-O', 'bradycardia-B-Disease', 'induced-O', 'by-O', 'bepridil-B-Chemical', '.-O']
['Bepridil-B-Chemical', ',-O', 'a-O', 'novel-O', 'active-O', 'compound-O', 'for-O', 'prophylactic-O', 'treatment-O', 'of-O', 'anginal-B-Disease', 'attacks-O', ',-O', 'induced-O', 'persistent-O', 'bradycardia-B-Disease', 'and-O', 'a-O', 'non-O', ',-O', 'specific-O', 'anti-O', ',-O', 'tachycardial-O', 'effect-O', ',-O', 'the-O', 'mechanisms-O', 'of-O', 'which-O', 'were-O', 'investigated-O', 'in-O', 'vitro-O', 'and-O', 'in-O', 'vivo-O', '.-O']
['In-O', 'vitro-O', 'perfusion-O', 'of-O', 'bepridil-B-Chemical', 'in-O', 'the-O', 'life-O', ',-O', 'support-O', 'medium-O', 'for-O', 'isolated-O', 'sino-O', ',-O', 'atrial-O', 'tissue-O', 'from-O', 'rabbit-O', 'heart-O', ',-O', 'caused-O', 'a-O', 'reduction-O', 'in-O', 'action-O', 'potential-O', '(-O', 'AP-O', ')-O', 'spike-O', 'frequency-O', '(-O', 'recorded-O', 'by-O', 'KCl-B-Chemical', 'microelectrodes-O', ')-O', 'starting-O', 'at-O', 'doses-O', 'of-O', '5-O', 'X-O', '10-O', '(-O', '6-O', ')-O', 'M-O', '.-O']
['This-O', 'effect-O', 'was-O', 'dose-O', ',-O', 'dependent-O', 'up-O', 'to-O', 'concentrations-O', 'of-O', '5-O', 'X-O', '10-O', '(-O', '5-O', ')-O', 'M-O', ',-O', 'whereupon-O', 'blockade-O', 'of-O', 'sinus-B-Disease', 'activity-O', 'set-O', 'in-O', '.-O']
['Bepridil-B-Chemical', 'at-O', 'a-O', 'dose-O', 'of-O', '5-O', 'X-O', '10-O', '(-O', '6-O', ')-O', 'M-O', ',-O', 'induced-O', 'a-O', 'concomitant-O', 'reduction-O', 'in-O', 'AP-O', 'amplitude-O', '(-O', 'falling-O', 'from-O', '71-O', '+-O', '8-O', 'mV-O', 'to-O', '47-O', '+-O', '6-O', 'mV-O', ')-O', 'maximum-O', 'systolic-O', 'depolarization-O', 'velocity-O', '(-O', 'phase-O', '0-O', ')-O', 'which-O', 'fell-O', 'from-O', '1-O', '.-O']
['85-O', '+-O', '0-O', '.-O']
['35-O', 'V-O', '/-O', 's-O', 'to-O', '0-O', '.-O']
['84-O', '+-O', '0-O', '.-O']
['28-O', 'V-O', '/-O', 's-O', ',-O', 'together-O', 'with-O', 'maximum-O', 'diastolic-O', 'depolarization-O', 'velocity-O', '(-O', 'phase-O', '4-O', ')-O', 'which-O', 'fell-O', 'from-O', '38-O', '+-O', '3-O', 'mV-O', '/-O', 's-O', 'to-O', '24-O', '+-O', '5-O', 'mV-O', '/-O', 's-O', '.-O']
['In-O', 'vivo-O', 'injection-O', 'of-O', 'bepridil-B-Chemical', 'at-O', 'a-O', 'dose-O', 'of-O', '5-O', 'mg-O', '/-O', 'kg-O', '(-O', 'i-O', '.-O']
['v-O', ')-O', 'into-O', '6-O', 'anaesthetized-O', 'dogs-O', 'which-O', 'had-O', 'undergone-O', 'ablation-O', 'of-O', 'all-O', 'the-O', 'extrinsic-O', 'cardiac-O', 'afferent-O', 'nerve-O', 'supply-O', ',-O', 'together-O', 'with-O', 'a-O', 'bilateral-O', 'medullo-O', ',-O', 'adrenalectomy-O', ',-O', 'caused-O', 'a-O', 'marked-O', 'reduction-O', 'in-O', 'heart-O', 'rate-O', 'which-O', 'fell-O', 'from-O', '98-O', '.-O']
['7-O', '+-O', '4-O', '.-O']
['2-O', 'beats-O', '/-O', 'min-O', 'to-O', '76-O', '+-O', '5-O', '.-O']
['3-O', 'beats-O', '/-O', 'min-O', 'sustained-O', 'for-O', 'more-O', 'than-O', '45-O', 'min-O', '.-O']
['It-O', 'is-O', 'concluded-O', 'that-O', 'bepridil-B-Chemical', 'reduces-O', 'heart-O', 'rate-O', 'by-O', 'acting-O', 'directly-O', 'on-O', 'the-O', 'sinus-O', 'node-O', '.-O']
['This-O', 'effect-O', ',-O', 'which-O', 'results-O', 'in-O', 'a-O', 'flattening-O', 'of-O', 'the-O', 'phase-O', '0-O', 'and-O', 'phase-O', '4-O', 'slope-O', ',-O', 'together-O', 'with-O', 'a-O', 'longer-O', 'AP-O', 'duration-O', ',-O', 'may-O', 'be-O', 'due-O', 'to-O', 'an-O', 'increase-O', 'in-O', 'the-O', 'time-O', 'constants-O', 'of-O', 'slow-O', 'inward-O', 'ionic-O', 'currents-O', '(-O', 'already-O', 'demonstrated-O', 'elsewhere-O', ')-O', 'but-O', 'also-O', 'to-O', 'an-O', 'increased-O', 'time-O', 'constant-O', 'for-O', 'deactivation-O', 'of-O', 'the-O', 'outward-O', 'potassium-O', '.-O']
['Hepatitis-B-Disease', 'and-O', 'renal-O', 'tubular-O', 'acidosis-B-Disease', 'after-O', 'anesthesia-O', 'with-O', 'methoxyflurane-B-Chemical', '.-O']
['A-O', '69-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'operated-O', 'for-O', 'acute-B-Disease', 'cholecystitis-I-Disease', 'under-O', 'methoxyflurane-B-Chemical', 'anesthesia-O', 'developed-O', 'postoperatively-O', 'a-O', 'hepatic-B-Disease', 'insufficiency-O', 'syndrome-O', 'and-O', 'renal-B-Disease', 'tubular-O', 'acidosis-B-Disease', '.-O']
['Massive-O', 'bleeding-B-Disease']
['Pituitary-O', 'response-O', 'to-O', 'luteinizing-O', 'hormone-O', ',-O', 'releasing-O', 'hormone-O', 'during-O', 'haloperidol-B-Chemical', ',-O', 'induced-O', 'hyperprolactinemia-B-Disease', '.-O']
['The-O', 'effects-O', 'of-O', 'a-O', '6-O', ',-O', 'hour-O', 'infusion-O', 'with-O', 'haloperidol-B-Chemical', 'on-O', 'serum-O', 'prolactin-O', 'and-O', 'luteinizing-O', 'hormone-O', '(-O', 'LH-O', ')-O', 'levels-O', 'was-O', 'studied-O', 'in-O', 'a-O', 'group-O', 'of-O', 'male-O', 'subjects-O', '.-O']
['Five-O', 'hours-O', 'after-O', 'starting-O', 'the-O', 'infusions-O', ',-O', 'a-O', 'study-O', 'of-O', 'the-O', 'pituitary-O', 'responses-O', 'to-O', 'LH-O', ',-O', 'releasing-O', 'hormone-O', '(-O', 'LH-O', ',-O', 'RH-O', ')-O', 'was-O', 'carried-O', 'out-O', '.-O']
['Control-O', 'patients-O', 'received-O', 'infusions-O', 'of-O', '0-O', '.-O']
['9-O', '%-O', 'NaCl-B-Chemical', 'solution-O', '.-O']
['During-O', 'the-O', 'course-O', 'of-O', 'haloperidol-B-Chemical', 'infusions-O', ',-O', 'significant-O', 'hyperprolactinemia-B-Disease']
['Antirifampicin-O', 'antibodies-O', 'in-O', 'acute-O', 'rifampicin-B-Chemical', ',-O', 'associated-O', 'renal-B-Disease', 'failure-I-Disease', '.-O']
['5-O', 'patients-O', 'with-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', '(-O', '3-O', 'with-O', 'thrombopenia-B-Disease', 'and-O', 'hemolysis-B-Disease', ')-O', 'induced-O', 'by-O', 'the-O', 'reintroduction-O', 'of-O', 'rifampicin-B-Chemical', 'are-O', 'described-O', '.-O']
['No-O', 'correlation-O', 'was-O', 'found-O', 'between-O', 'the-O', 'severity-O', 'of-O', 'clinical-O', 'manifestations-O', 'and-O', 'the-O', 'total-O', 'dose-O', 'taken-O', 'by-O', 'the-O', 'patients-O', '.-O']
['In-O', 'all-O', 'but-O', '1-O', 'patient-O', ',-O', 'antirifampicin-B-Chemical', 'antibodies-O', 'were-O', 'detected-O', '.-O']
['Antibodies-O', 'suggested-O', 'to-O', 'be-O', 'of-O', 'the-O', 'IgM-O', 'class-O', 'were-O', 'detected-O', 'in-O', 'all-O', '3-O', 'patients-O', 'with-O', 'hematological-B-Disease', 'disorders-I-Disease', '.-O']
['The-O', 'pattern-O', 'of-O', 'non-O', ',-O', 'specific-O', 'acute-O', 'tubular-B-Disease', 'necrosis-I-Disease']
['Cardiovascular-O', 'effects-O', 'of-O', 'hypotension-B-Disease', 'induced-O', 'by-O', 'adenosine-B-Chemical', 'triphosphate-B-Chemical', 'and-O', 'sodium-B-Chemical', 'nitroprusside-I-Chemical', 'on-O', 'dogs-O', 'with-O', 'denervated-O', 'hearts-O', '.-O']
['Adenosine-B-Chemical', 'triphosphate-B-Chemical', '(-O', 'ATP-B-Chemical', ')-O', 'and-O', 'sodium-B-Chemical', 'nitroprusside-I-Chemical', '(-O', 'SNP-B-Chemical', ')-O', 'are-O', 'administered-O', 'to-O', 'patients-O', 'to-O', 'induce-O', 'and-O', 'control-O', 'hypotension-B-Disease', 'during-O', 'anesthesia-O', '.-O']
['SNP-B-Chemical', 'is-O', 'authorized-O', 'for-O', 'clinical-O', 'use-O', 'in-O', 'USA-O', 'and-O', 'UK-O', ',-O', 'and-O', 'ATP-B-Chemical', 'is-O', 'clinically-O', 'used-O', 'in-O', 'other-O', 'countries-O', 'such-O', 'as-O', 'Japan-O', '.-O']
['We-O', 'investigated-O', 'how-O', 'these-O', 'two-O', 'drugs-O', 'act-O', 'on-O', 'the-O', 'cardiovascular-O', 'systems-O', 'of-O', '20-O', 'dogs-O', 'whose-O', 'hearts-O', 'had-O', 'been-O', 'denervated-O', 'by-O', 'a-O', 'procedure-O', 'we-O', 'had-O', 'devised-O', '.-O']
['ATP-B-Chemical', '(-O', '10-O', 'dogs-O', ')-O', 'or-O', 'SNP-B-Chemical', '(-O', '10-O', 'dogs-O', ')-O', 'was-O', 'administered-O', 'to-O', 'reduce-O', 'mean-O', 'arterial-O', 'pressure-O', 'by-O', '30-O', '%-O', 'to-O', '70-O', '%-O', 'of-O', 'control-O', '.-O']
['Before-O', ',-O', 'during-O', 'and-O', 'after-O', 'induced-O', 'hypotension-B-Disease', ',-O', 'we-O', 'measured-O', 'major-O', 'cardiovascular-O', 'parameters-O', '.-O']
['Hypotension-B-Disease', 'induced-O', 'by-O', 'ATP-B-Chemical', 'was-O', 'accompanied-O', 'by-O', 'significant-O', 'decreases-O', 'in-O', 'mean-O', 'pulmonary-O', 'arterial-O', 'pressure-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'central-O', 'venous-O', 'pressure-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'left-O', 'ventricular-O', 'end-O', ',-O', 'diastolic-O', 'pressure-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'total-O', 'peripheral-O', 'resistance-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'rate-O', 'pressure-O', 'product-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', ')-O', 'total-O', 'body-O', 'oxygen-B-Chemical', 'consumption-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', '),-O', 'and-O', 'heart-O', 'rate-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', ')-O', 'all-O', 'these-O', 'variables-O', 'returned-O', 'normal-O', 'within-O', '30-O', 'min-O', 'after-O', 'ATP-B-Chemical', 'was-O', 'stopped-O', '.-O']
['Cardiac-O', 'output-O', 'did-O', 'not-O', 'change-O', '.-O']
['During-O', 'hypotension-B-Disease', 'produced-O', 'by-O', 'SNP-B-Chemical', 'similar-O', 'decreases-O', 'were-O', 'observed-O', 'in-O', 'mean-O', 'pulmonary-O', 'arterial-O', 'pressure-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ')-O', 'central-O', 'venous-O', 'pressure-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'left-O', 'ventricular-O', 'end-O', ',-O', 'diastolic-O', 'pressure-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['01-O', ')-O', 'total-O', 'peripheral-O', 'resistance-B-Disease', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'rate-O', 'pressure-O', 'product-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', '),-O', 'and-O', 'oxygen-B-Chemical', 'content-O', 'difference-O', 'between-O', 'arterial-O', 'and-O', 'mixed-O', 'venous-O', 'blood-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', '),-O', 'while-O', 'heart-O', 'rate-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['001-O', ')-O', 'and-O', 'cardiac-O', 'output-O', '(-O', 'p-O', 'less-O', 'than-O', '0-O', '.-O']
['05-O', ')-O', 'were-O', 'increased-O', '.-O']
['Recoveries-O', 'of-O', 'heart-O', 'rate-O', 'and-O', 'left-O', 'ventricular-O', 'end-O', ',-O', 'diastolic-O', 'pressure-O', 'were-O', 'not-O', 'shown-O', 'within-O', '60-O', 'min-O', 'after-O', 'SNP-B-Chemical', 'had-O', 'been-O', 'stopped-O', '.-O']
['Both-O', 'ATP-B-Chemical', 'and-O', 'SNP-B-Chemical']
['Comparative-O', 'study-O', ':-O', 'Endografine-B-Chemical', '(-O', 'diatrizoate-B-Chemical', '),', 'Vasurix-B-Chemical', 'polyvidone-O', '(-O', 'acetrizoate-B-Chemical', '),', 'Dimer-X-B-Chemical', '(-O', 'iocarmate-B-Chemical', ')', 'and-O', 'Hexabrix-B-Chemical', '(-O', 'ioxaglate-B-Chemical', ')', 'in-O', 'hysterosalpingography-O', '.-O']
['Side-O', 'effects-O', 'of-O', 'hysterosalpingography-O', 'with-O', 'Dimer-X-B-Chemical', ',-O', 'Hexabrix-B-Chemical', ',-O', 'Vasurix-B-Chemical', 'polyvidone-B-Chemical', 'and-O', 'Endografine-B-Chemical', 'in-O', '142-O', 'consecutive-O', 'patients-O', ',-O', 'receiving-O', 'one-O', 'of-O', 'the-O', 'four-O', 'tested-O', 'media-O', 'were-O', 'evaluated-O', 'from-O', 'replies-O', 'to-O', 'postal-O', 'questionnaires-O', '.-O']
['The-O', 'Dimer-X-B-Chemical', 'group-O', 'had-O', 'a-O', 'higher-O', 'incidence-O', 'of-O', 'nausea-B-Disease', 'and-O', 'dizziness-B-Disease', '.-O']
['The-O', 'Endografine-B-Chemical', 'group-O', 'had-O', 'a-O', 'higher-O', 'incidence-O', 'of-O', 'abdominal-O', 'pain-B-Disease', '.-O']
['These-O', 'differences-O', 'occur-O', 'especially-O', 'in-O', 'the-O', 'age-O', 'groups-O', 'under-O', '30-O', 'years-O', '.-O']
['Hexabrix-B-Chemical', 'and-O', 'Vasurix-B-Chemical', 'polyvidone-O', 'are-O', 'considered-O', 'the-O', 'best-O', 'contrast-B-Chemical', 'media-O', 'for-O', 'hysterosalpingography-O', 'and-O', 'perhaps-O', 'because-O', 'of-O', 'its-O', 'low-O', 'toxicity-O', 'Hexabrix-B-Chemical']
['Post-O', ',-O', 'suxamethonium-B-Chemical', 'pains-B-Disease', 'in-O', 'Nigerian-O', 'surgical-O', 'patients-O', '.-O']
['Contrary-O', 'to-O', 'an-O', 'earlier-O', 'report-O', 'by-O', 'Coxon-O', ',-O', 'scoline-B-Chemical', 'pain-B-Disease', 'occurs-O', 'in-O', 'African-O', 'negroes-O', '.-O']
['Its-O', 'incidence-O', 'was-O', 'determined-O', 'in-O', 'a-O', 'prospective-O', 'study-O', 'involving-O', 'a-O', 'total-O', 'of-O', '100-O', 'Nigerian-O', 'patients-O', '(-O', '50-O', 'out-O', '-O', 'patients-O', 'and-O', '50-O', 'in-O', '-O', 'patients-O', ')-O', '.-O', 'About-O', '62-O', '%-O', 'of-O', 'the-O', 'out-O', '-O', 'patients-O', 'developed-O', 'scoline-B-Chemical', 'pain-O', 'as-O', 'compared-O', 'with-O', 'about-O', '26-O', '%-O', 'among-O', 'the-O', 'in-O', '-O', 'patients-O', '.-O']
['The-O', 'abolition-O', 'of-O', 'muscle-B-Disease', 'fasciculations-I-Disease', '(-O', 'by-O', '0-O', '.-O']
['075mg-O', '/-O', 'kg-O', 'dose-O', 'of-O', 'Fazadinium-B-Chemical', ')-O', 'did-O', 'not-O', 'influence-O', 'the-O', 'occurrence-O', 'of-O', 'scoline-B-Chemical', 'pain-B-Disease', '.-O']
['Neither-O', 'the-O', 'type-O', 'of-O', 'induction-O', 'agent-O', '(-O', 'Althesin-B-Chemical', 'or-O', 'Thiopentone-B-Chemical', ')-O', 'nor-O', 'the-O', 'salt-B-Chemical', 'preparation-O', 'of-O', 'suxamethonium-B-Chemical', 'used-O', '(-O', 'chloride-I-Chemical', 'or-O', 'bromide-I-Chemical', ')-O', 'affected-O', 'the-O', 'incidence-O', 'of-O', 'scoline-B-Chemical', 'pain-B-Disease']
['Medial-O', 'changes-O', 'in-O', 'arterial-O', 'spasm-B-Disease', 'induced-O', 'by-O', 'L-norepinephrine-B-Chemical', '.-O']
['In-O', 'normal-O', 'rats-O', ',-O', 'the-O', 'media-O', 'of-O', 'small-O', 'arteries-O', '(-O', '0-O', '.-O']
['4-O', '--O', '0-O', '.-O']
['2-O', 'mm-O', 'in-O', 'diameter-O', ')-O', 'previously-O', 'was-O', 'shown-O', 'to-O', 'contain-O', 'intracellular-O', 'vacuoles-O', ',-O', 'identified-O', 'ultrastructurally-O', 'as-O', 'herniations-O', 'of-O', 'one-O', 'smooth-O', 'muscle-O', 'cell-O', 'into-O', 'another-O', '.-O']
['The-O', 'hypothesis-O', 'that-O', 'intense-O', 'vasoconstriction-O', 'would-O', 'increase-O', 'the-O', 'number-O', 'of-O', 'such-O', 'vacuoles-O', 'has-O', 'been-O', 'tested-O', '.-O']
['In-O', 'the-O', 'media-O', 'of-O', 'the-O', 'saphenous-O', 'artery-O', 'and-O', 'its-O', 'distal-O', 'branch-O', ',-O', 'vasoconstriction-O', 'induced-O', 'by-O', 'L-norepinephrine-B-Chemical', 'produced-O', 'many-O', 'cell-O', ',-O', 'to-O', ',-O', 'cell-O', 'hernias-O', 'within-O', '15-O', 'minutes-O', '.-O']
['At-O', '1-O', 'day-O', 'their-O', 'number-O', 'was-O', 'reduced-O', 'to-O', 'about-O', '1-O', '/-O', '10-O', 'of-O', 'the-O', 'original-O', 'number-O', '.-O']
['By-O', '7-O', 'days-O', 'the-O', 'vessel-O', 'was-O', 'almost-O', 'restored-O', 'to-O', 'normal-O', '.-O']
['Triple-O', 'stimulation-O', 'over-O', '1-O', 'day-O', 'induced-O', 'more-O', 'severe-O', 'changes-O', 'in-O', 'the-O', 'media-O', '.-O']
['These-O', 'findings-O', 'suggest-O', 'that-O', 'smooth-O', 'muscle-O', 'cells-O', 'are-O', 'susceptible-O', 'to-O', 'damage-I-Disease', 'in-O', 'the-O', 'course-O', 'of-O', 'their-O', 'specific-O', 'function-O', '.-O']
['The-O', 'experimental-O', 'data-O', 'are-O', 'discussed-O', 'in-O', 'relation-O', 'to-O', 'medial-O', 'changes-O', 'observed-O', 'in-O', 'other-O', 'instances-O', 'of-O', 'arterial-B-Disease', 'spasm-B-Disease']
['Abnormalities-O', 'of-O', 'the-O', 'pupil-O', 'and-O', 'visual-B-Disease', ',-O', 'evoked-O', 'potential-O', 'in-O', 'quinine-B-Chemical', 'amblyopia-B-Disease', '.-O']
['Total-O', 'blindness-B-Disease', 'with-O', 'a-O', 'transient-O', 'tonic-O', 'pupillary-O', 'response-O', ',-O', 'denervation-O', 'supersensitivity-O', ',-O', 'and-O', 'abnormal-O', 'visual-O', ',-O', 'evoked-O', 'potentials-O', 'developed-O', 'in-O', 'a-O', '54-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'after-O', 'the-O', 'use-O', 'of-O', 'quinine-B-Chemical', 'sulfate-O', 'for-O', 'leg-O', 'cramps-O', '.-O']
['He-O', 'later-O', 'recovered-O', 'normal-O', 'visual-B-Disease', 'acuity-O', '.-O']
['A-O', 'transient-O', 'tonic-O', 'pupillary-O', 'response-O', ',-O', 'denervation-O', 'supersensitivity-O', ',-O', 'and-O', 'abnormal-O', 'visual-O', ',-O', 'evoked-O', 'potentials-O', 'in-O', 'quinine-B-Chemical', 'toxicity-B-Disease']
['Suxamethonium-B-Chemical', ',-O', 'induced-O', 'jaw-O', 'stiffness-B-Disease', 'and-O', 'myalgia-B-Disease', 'associated-O', 'with-O', 'atypical-O', 'cholinesterase-B-Chemical', ':-O', 'case-O', 'report-O', '.-O']
['An-O', '11-O', ',-O', 'year-O', ',-O', 'old-O', 'boy-O', 'was-O', 'given-O', 'halothane-B-Chemical', ',-O', 'nitrous-B-Chemical', 'oxide-I-Chemical', 'and-O', 'oxygen-B-Chemical', ',-O', 'pancuronium-B-Chemical', '0-O', '.-O']
['4-O', 'mg-O', 'and-O', 'suxamethonium-B-Chemical', '100-O', 'mg-O', 'for-O', 'induction-O', 'of-O', 'anaesthesia-O', '.-O']
['In-O', 'response-O', 'to-O', 'this-O', 'a-O', 'marked-O', 'jaw-O', 'stiffness-B-Disease', 'occurred-O', 'which-O', 'lasted-O', 'for-O', 'two-O', 'minutes-O', 'and-O', 'the-O', 'anaesthesia-O', 'were-O', 'terminated-O', '.-O']
['Four-O', 'hours-O', 'of-O', 'apnoea-B-Disease', 'ensued-O', 'and-O', 'he-O', 'suffered-O', 'generalized-O', 'severe-O', 'myalgia-B-Disease', 'lasting-O', 'for-O', 'one-O', 'week-O', '.-O']
['He-O', 'was-O', 'found-O', 'to-O', 'have-O', 'atypical-O', 'plasma-O', 'cholinesterase-O', 'with-O', 'a-O', 'dibucaine-B-Chemical', 'number-O', 'of-O', '12-O', ',-O', 'indicating-O', 'homozygocity-O', '.-O']
['This-O', 'was-O', 'verified-O', 'by-O', 'study-O', 'of-O', 'the-O', 'family-O', '.-O']
['The-O', 'case-O', 'shows-O', 'that-O', 'prolonged-O', 'jaw-O', 'rigidity-B-Disease', 'and-O', 'myalgia-B-Disease', 'may-O', 'occur-O', 'after-O', 'suxamethonium-B-Chemical', 'in-O', 'patients-O', 'with-O', 'atypical-O', 'cholinesterase-O', 'despite-O', 'pretreatment-O', 'with-O', 'pancuronium-B-Chemical']
['Indomethacin-B-Chemical', ',-O', 'induced-O', 'hyperkalemia-B-Disease', 'in-O', 'three-O', 'patients-O', 'with-O', 'gouty-B-Disease', 'arthritis-I-Disease', '.-O']
['We-O', 'describe-O', 'three-O', 'patients-O', 'in-O', 'whom-O', 'severe-O', ',-O', 'life-O', ',-O', 'threatening-O', 'hyperkalemia-B-Disease', 'and-O', 'renal-B-Disease', 'insufficiency-I-Disease', 'developed-O', 'after-O', 'treatment-O', 'of-O', 'acute-O', 'gouty-O', 'arthritis-B-Disease', 'with-O', 'indomethacin-B-Chemical', '.-O']
['This-O', 'complication-O', 'may-O', 'result-O', 'from-O', 'an-O', 'inhibition-O', 'of-O', 'prostaglandin-B-Chemical', 'synthesis-O', 'and-O', 'consequent-O', 'hyporeninemic-B-Disease', 'hypoaidosteronism-B-Disease', '.-O']
['Careful-O', 'attention-O', 'to-O', 'renal-O', 'function-O', 'and-O', 'potassium-B-Chemical', 'balance-O', 'in-O', 'patients-O', 'receiving-O', 'indomethacin-B-Chemical', 'or-O', 'other-O', 'nonsteroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'agents-O', ',-O', 'particularly-O', 'in-O', 'those-O', 'patients-O', 'with-O', 'diabetes-B-Disease', 'mellitus-I-Disease', 'or-O', 'preexisting-O', 'renal-B-Disease', 'disease-I-Disease']
['Etomidate-B-Chemical', ':-O', 'a-O', 'foreshortened-O', 'clinical-O', 'trial-O', '.-O']
['A-O', 'clinical-O', 'evaluation-O', 'of-O', 'etomidate-B-Chemical', 'for-O', 'outpatient-O', 'cystoscopy-O', 'was-O', 'embarked-O', 'upon-O', '.-O']
['Unpremedicated-O', 'patients-O', 'were-O', 'given-O', 'fentanyl-B-Chemical', '1-O', 'microgram-O', '/-O', 'kg-O', 'followed-O', 'by-O', 'etomidate-B-Chemical', '0-O', '.-O']
['3-O', 'mg-O', '/-O', 'kg-O', '.-O']
['Anaesthesia-O', 'was-O', 'maintained-O', 'with-O', 'intermittent-O', 'etomidate-B-Chemical', 'in-O', '2-O', ',-O', '4-O', 'mg-O', 'doses-O', '.-O']
['Patients-O', 'were-O', 'interviewed-O', 'personally-O', 'later-O', 'the-O', 'same-O', 'day-O', ',-O', 'and-O', 'by-O', 'questionnaire-O', 'three-O', 'to-O', 'four-O', 'weeks-O', 'later-O', '.-O']
['The-O', 'trial-O', 'was-O', 'discontinued-O', 'after-O', '20-O', 'cases-O', 'because-O', 'of-O', 'an-O', 'unacceptable-O', 'incidence-O', 'of-O', 'side-O', 'effects-O', '.-O']
['Venous-O', 'pain-B-Disease', 'occurred-O', 'in-O', '68-O', '%-O', 'of-O', 'patients-O', 'and-O', '50-O', '%-O', 'had-O', 'redness-O', ',-O', 'pain-B-Disease', 'or-O', 'swelling-O', 'related-O', 'to-O', 'the-O', 'injection-O', 'site-O', ',-O', 'in-O', 'some-O', 'cases-O', 'lasting-O', 'up-O', 'to-O', 'three-O', 'weeks-O', 'after-O', 'anaesthesia-O', '.-O']
['Skeletal-B-Disease', 'movements-O', 'occurred-O', 'in-O', '50-O', '%-O', 'of-O', 'patients-O', ';-O', '30-O', '%-O', 'experienced-O', 'respiratory-B-Disease', 'upset-O', ',-O', 'one-O', 'sufficiently-O', 'severe-O', 'to-O', 'necessitate-O', 'abandoning-O', 'the-O', 'technique-O', '.-O']
['Nausea-B-Disease', 'and-O', 'vomiting-B-Disease', 'occurred-O', 'in-O', '40-O', '%-O', 'and-O', '25-O', '%-O', 'had-O', 'disturbing-O', 'emergence-O', 'psychoses-B-Disease']
['Levodopa-B-Chemical', ',-O', 'induced-O', 'dyskinesias-B-Disease', 'are-O', 'improved-O', 'by-O', 'fluoxetine-B-Chemical', '.-O']
['We-O', 'evaluated-O', 'the-O', 'severity-O', 'of-O', 'motor-O', 'disability-O', 'and-O', 'dyskinesias-B-Disease', 'in-O', 'seven-O', 'levodopa-B-Chemical', ',-O', 'responsive-O', 'patients-O', 'with-O', 'Parkinson-B-Disease', 'disease-I-Disease', 'after-O', 'an-O', 'acute-O', 'challenge-O', 'with-O', 'the-O', 'mixed-O', 'dopamine-B-Chemical', 'agonist-O', ',-O', 'apomorphine-B-Chemical', ',-O', 'before-O', 'and-O', 'after-O', 'the-O', 'administration-O', 'of-O', 'fluoxetine-B-Chemical', '(-O', '20-O', 'mg-O', 'twice-O', 'per-O', 'day-O', ')-O', 'for-O', '11-O', '+-O', '1-O', 'days-O', '.-O']
['After-O', 'fluoxetine-B-Chemical', 'treatment-O', ',-O', 'there-O', 'was-O', 'a-O', 'significant-O', '47-O', '%-O', 'improvement-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ')-O', 'of-O', 'apomorphine-B-Chemical', ',-O', 'induced-O', 'dyskinesias-B-Disease', 'without-O', 'modification-O', 'of-O', 'parkinsonian-B-Disease', 'motor-B-Disease', 'disability-I-Disease', '.-O']
['The-O', 'dyskinesias-B-Disease', 'were-O', 'reduced-O', 'predominantly-O', 'in-O', 'the-O', 'lower-O', 'limbs-O', 'during-O', 'the-O', 'onset-O', 'and-O', 'disappearance-O', 'of-O', 'dystonic-O', 'dyskinesias-B-Disease', '(-O', 'onset-O', ',-O', 'and-O', 'end-O', ',-O', 'of-O', ',-O', 'dose-O', 'dyskinesias-O', ')-O', 'and-O', 'in-O', 'the-O', 'upper-O', 'limbs-O', 'during-O', 'choreic-O', 'mid-dose-O', 'dyskinesias-B-Disease', '.-O']
['The-O', 'results-O', 'suggest-O', 'that-O', 'increased-O', 'brain-O', 'serotoninergic-O', 'transmission-O', 'with-O', 'fluoxetine-B-Chemical', 'may-O', 'reduce-O', 'levodopa-B-Chemical', ',-O', 'or-O', 'dopamine-B-Chemical', 'agonist-O', ',-O', 'induced-O', 'dyskinesias-B-Disease', 'without-O', 'aggravating-O', 'parkinsonian-B-Disease', 'motor-B-Disease', 'disability-I-Disease']
['A-O', 'large-O', 'population-O', ',-O', 'based-O', 'follow-O', '--O', 'up-O', 'study-O', 'of-O', 'trimethoprim-sulfamethoxazole-B-Chemical', ',-O', 'trimethoprim-B-Chemical', ',-O', 'and-O', 'cephalexin-B-Chemical', 'for-O', 'uncommon-O', 'serious-O', 'drug-B-Disease', 'toxicity-I-Disease', '.-O']
['We-O', 'conducted-O', 'a-O', 'population-O', ',-O', 'based-O', '45-O', ',-O', 'day-O', 'follow-O', ',-O', 'up-O', 'study-O', 'of-O', '232-O', ',-O', '390-O', 'people-O', 'who-O', 'were-O', 'prescribed-O', 'trimethoprim-sulfamethoxazole-B-Chemical', '(-O', 'TMP-SMZ-B-Chemical', ')-O', ',-O', '266-O', ',-O', '951-O', 'prescribed-O', 'trimethoprim-B-Chemical', 'alone-O', ',-O', 'and-O', '196-O', ',-O', '397-O', 'prescribed-O', 'cephalexin-B-Chemical', ',-O', 'to-O', 'estimate-O', 'the-O', 'risk-O', 'of-O', 'serious-O', 'liver-O', ',-O', 'blood-O', ',-O', 'skin-O', ',-O', 'and-O', 'renal-O', 'disorders-O', 'resulting-O', 'in-O', 'referral-O', 'or-O', 'hospitalization-O', 'associated-O', 'with-O', 'these-O', 'drugs-O', '.-O']
['The-O', 'results-O', 'were-O', 'based-O', 'on-O', 'information-O', 'recorded-O', 'on-O', 'office-O', 'computers-O', 'by-O', 'selected-O', 'general-O', 'practitioners-O', 'in-O', 'the-O', 'United-O', 'Kingdom-O', ',-O', 'together-O', 'with-O', 'a-O', 'review-O', 'of-O', 'clinical-O', 'records-O', '.-O']
['The-O', 'risk-O', 'of-O', 'clinically-O', 'important-O', 'idiopathic-B-Disease', 'liver-B-Disease', 'disease-I-Disease', 'was-O', 'similar-O', 'for-O', 'persons-O', 'prescribed-O', 'TMP-SMZ-B-Chemical', '(-O', '5-O', '.-O']
['2-O', '/-O', '100-O', ',-O', '000-O', ')-O', 'and-O', 'those-O', 'prescribed-O', 'trimethoprim-B-Chemical', 'alone-O', '(-O', '3-O', '.-O']
['8-O', '/-O', '100-O', ',-O', '000-O', ')-O', '.-O', 'The-O', 'risk-O', 'for-O', 'those-O', 'prescribed-O', 'cephalexin-B-Chemical', 'was-O', 'somewhat-O', 'lower-O', '(-O', '2-O', '.-O']
['0-O', '/-O', '100-O', ',', '000-O', ').-O', 'Only-O', 'five-O', 'patients-O', 'experienced-O', 'blood-O', 'disorders-O', ',-O', 'one-O', 'of-O', 'whom-O', 'was-O', 'exposed-O', 'to-O', 'TMP-SMZ-B-Chemical', ';-O', 'of-O', 'seven-O', 'with-O', 'erythema-B-Disease', 'multiforme-I-Disease', 'and-O', 'Stevens-Johnson-B-Disease', 'syndrome-I-Disease', ',-O', 'four-O', 'were-O', 'exposed-O', 'to-O', 'TMP-SMZ-B-Chemical', '.-O']
['The-O', 'one-O', 'case-O', 'of-O', 'toxic-O', 'epidermal-B-Disease', 'necrolysis-I-Disease', 'occurred-O', 'in-O', 'a-O', 'patient-O', 'who-O', 'took-O', 'cephalexin-B-Chemical', '.-O']
['Finally-O', ',-O', 'only-O', 'five-O', 'cases-O', 'of-O', 'acute-B-Disease', 'parenchymal-O', 'renal-I-Disease', 'disease-I-Disease']
['Clinical-O', 'safety-O', 'of-O', 'lidocaine-B-Chemical', 'in-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['STUDY-O', 'OBJECTIVE-O', ':-O', 'To-O', 'evaluate-O', 'the-O', 'safety-O', 'of-O', 'lidocaine-B-Chemical', 'in-O', 'the-O', 'setting-O', 'of-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'myocardial-B-Disease', 'infarction-I-Disease', '(-O', 'MI-B-Disease', ')-O', '.', 'DESIGN-O', ':-O', 'A-O', 'retrospective-O', ',-O', 'multicenter-O', 'study-O', '.-O']
['SETTING-O', ':-O', 'Twenty-O', ',-O', 'nine-O', 'university-O', ',-O', 'university-O', ',-O', 'affiliated-O', ',-O', 'or-O', 'community-O', 'hospitals-O', 'during-O', 'a-O', '6-O', ',-O', 'year-O', 'period-O', '(-O', 'total-O', 'of-O', '117-O', 'cumulative-O', 'hospital-O', ',-O', 'years-O', ')-O', '.-O', 'PARTICIPANTS-O', ':-O', 'Patients-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'MI-B-Disease', 'who-O', 'received-O', 'lidocaine-B-Chemical', 'in-O', 'the-O', 'emergency-O', 'department-O', '.-O']
['RESULTS-O', ':-O', 'Of-O', '29-O', 'patients-O', 'who-O', 'received-O', 'lidocaine-B-Chemical', 'in-O', 'the-O', 'setting-O', 'of-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'MI-B-Disease', ',-O', 'no-O', 'patient-O', 'died-O', ';-O', 'exhibited-O', 'bradydysrhythmias-B-Disease', ',-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', ',-O', 'or-O', 'ventricular-B-Disease', 'fibrillation-I-Disease', ';-O', 'or-O', 'experienced-O', 'seizures-B-Disease', 'after-O', 'administration-O', 'of-O', 'lidocaine-B-Chemical', '(-O', '95-O', '%-O', 'confidence-O', 'interval-O', ',-O', '0-O', '%-O', 'to-O', '11-O', ').-O', 'CONCLUSION-O', ':-O', 'Despite-O', 'theoretical-O', 'concerns-O', 'that-O', 'lidocaine-B-Chemical', 'may-O', 'enhance-O', 'cocaine-B-Chemical', 'toxicity-O', ',-O', 'the-O', 'use-O', 'of-O', 'lidocaine-B-Chemical', 'in-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'MI-B-Disease', 'was-O', 'not-O', 'associated-O', 'with-O', 'significant-O', 'cardiovascular-O', 'or-O', 'central-O', 'nervous-O', 'system-O', 'toxicity-O']
['Paclitaxel-B-Chemical', '3-O', ',', 'hour-O', 'infusion-O', 'given-O', 'alone-O', 'and-O', 'combined-O', 'with-O', 'carboplatin-B-Chemical', ':-O', 'preliminary-O', 'results-O', 'of-O', 'dose-O', ',', 'escalation-O', 'trials-O', '.-O']
['Paclitaxel-B-Chemical', '(-O', 'Taxol-B-Chemical', ';-O', 'Bristol-O', ',-O', 'Myers-O', 'Squibb-O', 'Company-O', ',-O', 'Princeton-O', ',-O', 'NJ-O', ')-O', 'by-O', '3-O', ',-O', 'hour-O', 'infusion-O', 'was-O', 'combined-O', 'with-O', 'carboplatin-B-Chemical', 'in-O', 'a-O', 'phase-O', 'I-O', '/-O', 'II-O', 'study-O', 'directed-O', 'to-O', 'patients-O', 'with-O', 'non-small-B-Disease', 'cell-I-Disease', 'lung-I-Disease', 'cancer-I-Disease', '.-O']
['Carboplatin-B-Chemical', 'was-O', 'given-O', 'at-O', 'a-O', 'fixed-O', 'target-O', 'area-O', 'under-O', 'the-O', 'concentration-O', ',-O', 'time-O', 'curve-O', 'of-O', '6-O', '.-O']
['0-O', 'by-O', 'the-O', 'Calvert-O', 'formula-O', ',-O', 'whereas-O', 'paclitaxel-B-Chemical', 'was-O', 'escalated-O', 'in-O', 'patient-O', 'cohorts-O', 'from-O', '150-O', 'mg-O', '/-O', 'm2-O', '(-O', 'dose-O', 'level-O', 'I-O', ')-O', 'to-O', '175-O', ',-O', '200-O', ',-O', '225-O', ',-O', 'and-O', '250-O', 'mg-O', '/-O', 'm2-O', '.-O']
['The-O', '225-O', 'mg-O', '/-O', 'm2-O', 'level-O', 'was-O', 'expanded-O', 'for-O', 'the-O', 'phase-O', 'II-O', 'study-O', 'since-O', 'the-O', 'highest-O', 'level-O', 'achieved-O', '(-O', '250-O', 'mg-O', '/-O', 'm2-O', ')-O', 'required-O', 'modification-O', 'because-O', 'of-O', 'nonhematologic-O', 'toxicities-O', '(-O', 'arthralgia-B-Disease', 'and-O', 'sensory-O', 'neuropathy-B-Disease', ')-O', '.-O', 'Therapeutic-O', 'effects-O', 'were-O', 'noted-O', 'at-O', 'all-O', 'dose-O', 'levels-O', ',-O', 'with-O', 'objective-O', 'responses-O', 'in-O', '17-O', '(-O', 'two-O', 'complete-O', 'and-O', '15-O', 'partial-O', 'regressions-O', ')-O', 'of-O', '41-O', 'previously-O', 'untreated-O', 'patients-O', '.-O']
['Toxicities-B-Disease', 'were-O', 'compared-O', 'with-O', 'a-O', 'cohort-O', 'of-O', 'patients-O', 'in-O', 'a-O', 'phase-O', 'I-O', 'trial-O', 'of-O', 'paclitaxel-B-Chemical', 'alone-O', 'at-O', 'identical-O', 'dose-O', 'levels-O', '.-O']
['Carboplatin-B-Chemical', 'did-O', 'not-O', 'appear-O', 'to-O', 'add-O', 'to-O', 'the-O', 'hematologic-O', 'toxicities-B-Disease', 'observed-O', ',-O', 'and-O', 'the-O', 'paclitaxel-B-Chemical', '/', 'carboplatin-B-Chemical']
['The-O', 'dose-O', ',-O', 'dependent-O', 'effect-O', 'of-O', 'misoprostol-B-Chemical', 'on-O', 'indomethacin-B-Chemical', ',-O', 'induced-O', 'renal-O', 'dysfunction-B-Disease', 'in-O', 'well-O', 'compensated-O', 'cirrhosis-B-Disease', '.-O']
['Misoprostol-B-Chemical', '(-O', '200-O', 'micrograms-O', ')-O', 'has-O', 'been-O', 'shown-O', 'to-O', 'acutely-O', 'counteract-O', 'the-O', 'indomethacin-B-Chemical', ',-O', 'induced-O', 'renal-B-Disease', 'dysfunction-I-Disease', 'in-O', 'well-O', 'compensated-O', 'cirrhotic-B-Disease', 'patients-O', '.-O']
['The-O', 'aim-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'determine-O', 'if-O', 'the-O', 'prophylactic-O', 'value-O', 'of-O', 'misoprostol-B-Chemical', 'was-O', 'dose-O', ',-O', 'dependent-O', '.-O']
['Parameters-O', 'of-O', 'renal-O', 'hemodynamics-O', 'and-O', 'tubular-O', 'sodium-O', 'and-O', 'water-O', 'handling-O', 'were-O', 'assessed-O', 'by-O', 'clearance-O', 'techniques-O', 'in-O', '26-O', 'well-O', 'compensated-O', 'cirrhotic-B-Disease', 'patients-O', 'before-O', 'and-O', 'after-O', 'an-O', 'oral-O', 'combination-O', 'of-O', '50-O', 'mg-O', 'of-O', 'indomethacin-B-Chemical', 'and-O', 'various-O', 'doses-O', 'of-O', 'misoprostol-B-Chemical', '.-O']
['The-O', '200-O', ',-O', 'micrograms-O', 'dose-O', 'was-O', 'able-O', 'to-O', 'totally-O', 'abolish-O', 'the-O', 'deleterious-O', 'renal-O', 'effects-O', 'of-O', 'indomethacin-B-Chemical', ',-O', 'whereas-O', 'the-O', '800-O', ',-O', 'micrograms-O', 'dose-O', 'resulted-O', 'in-O', 'significant-O', 'worsening-O', 'of-O', 'renal-O', 'hemodynamics-O', 'and-O', 'sodium-B-Chemical', 'retention-O', '.-O']
['These-O', 'changes-O', 'were-O', 'maximal-O', 'in-O', 'the-O', 'hour-O', 'immediately-O', 'after-O', 'medications-O', 'and-O', 'slowly-O', 'returned-O', 'toward-O', 'base-O', ',-O', 'line-O', 'levels-O', 'thereafter-O', '.-O']
['These-O', 'results-O', 'suggest-O', 'that-O', 'the-O', 'renal-O', 'protective-O', 'effects-O', 'of-O', 'misoprostol-B-Chemical', 'is-O', 'dose-O', ',-O', 'dependent-O', '.-O']
['However-O', ',-O', 'until-O', 'this-O', 'apparent-O', 'ability-O', 'of-O', '200-O', 'micrograms-O', 'of-O', 'misoprostol-B-Chemical', 'to-O', 'prevent-O', 'the-O', 'adverse-O', 'effects-O', 'of-O', 'indomethacin-B-Chemical', 'on-O', 'renal-O', 'function-O', 'is-O', 'confirmed-O', 'with-O', 'chronic-O', 'frequent-O', 'dosing-O', ',-O', 'it-O', 'would-O', 'be-O', 'prudent-O', 'to-O', 'avoid-O', 'nonsteroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'therapy-O', 'in-O', 'patients-O', 'with-O', 'cirrhosis-B-Disease']
['Increased-O', 'frequency-O', 'and-O', 'severity-O', 'of-O', 'angio-oedema-B-Disease', 'related-O', 'to-O', 'long-O', ',-O', 'term-O', 'therapy-O', 'with-O', 'angiotensin-converting-O', 'enzyme-O', 'inhibitor-O', 'in-O', 'two-O', 'patients-O', '.-O']
['Adverse-O', 'reactions-O', 'to-O', 'drugs-O', 'are-O', 'well-O', 'recognized-O', 'as-O', 'a-O', 'cause-O', 'of-O', 'acute-O', 'or-O', 'chronic-O', 'urticaria-B-Disease', ',-O', 'and-O', 'angio-oedema-B-Disease', '.-O']
['Angiotensin-converting-O', 'enzyme-O', '(ACE)-O', 'inhibitors-O', ',-O', 'used-O', 'to-O', 'treat-O', 'hypertension-B-Disease', 'and-O', 'congestive-B-Disease', 'heart-I-Disease', 'failure-I-Disease', ',-O', 'were-O', 'introduced-O', 'in-O', 'Europe-O', 'in-O', 'the-O', 'middle-O', 'of-O', 'the-O', 'eighties-O', ',-O', 'and-O', 'the-O', 'use-O', 'of-O', 'these-O', 'drugs-O', 'has-O', 'increased-O', 'progressively-O', '.-O']
['Soon-O', 'after-O', 'the-O', 'introduction-O', 'of-O', 'ACE-B-Chemical', 'inhibitors-I-Chemical', ',-O', 'acute-O', 'bouts-O', 'of-O', 'angio-oedema-B-Disease', 'were-O', 'reported-O', 'in-O', 'association-O', 'with-O', 'the-O', 'use-O', 'of-O', 'these-O', 'drugs-O', '.-O']
['We-O', 'wish-O', 'to-O', 'draw-O', 'attention-O', 'to-O', 'the-O', 'possibility-O', 'of-O', 'adverse-O', 'reactions-O', 'to-O', 'ACE-B-Chemical', 'inhibitors-I-Chemical', 'after-O', 'long-O', ',-O', 'term-O', 'use-O', 'and-O', 'in-O', 'patients-O', 'with-O', 'pre-O', ',-O', 'existing-O', 'angio-oedema-B-Disease', '.-O']
['Myoclonus-B-Disease', 'associated-O', 'with-O', 'lorazepam-B-Chemical', 'therapy-O', 'in-O', 'very-O', ',-O', 'low-O', ',-O', 'birth-O', ',-O', 'weight-O', 'infants-O', '.-O']
['Lorazepam-B-Chemical', 'is-O', 'being-O', 'used-O', 'with-O', 'increasing-O', 'frequency-O', 'as-O', 'a-O', 'sedative-O', 'in-O', 'the-O', 'newborn-O', 'and-O', 'the-O', 'young-O', 'infant-O', '.-O']
['Concern-O', 'has-O', 'been-O', 'raised-O', 'with-O', 'regard-O', 'to-O', 'the-O', 'safety-O', 'of-O', 'lorazepam-B-Chemical', 'in-O', 'this-O', 'age-O', 'group-O', ',-O', 'especially-O', 'in-O', 'very-O', ',-O', 'low-O', ',-O', 'birth-O', ',-O', 'weight-O', '(-O', 'VLBW-O', ';<', '1-O', ',', '500-O', 'g-O', ')', 'infants-O', '.-O']
['Three-O', 'young-O', 'infants-O', ',-O', 'all-O', 'of-O', 'birth-O', 'weight-O', '<-O', '1-O', ',-O', '500-O', 'g-O', ',-O', 'experienced-O', 'myoclonus-B-Disease', 'following-O', 'the-O', 'intravenous-O', 'administration-O', 'of-O', 'lorazepam-B-Chemical', '.-O']
['The-O', 'potential-O', 'neurotoxic-B-Disease', 'effects-O', 'of-O', 'the-O', 'drug-O', '(-O', 'and-O', 'its-O', 'vehicle-O', ')-O', 'in-O', 'this-O', 'population-O', 'are-O', 'discussed-O', '.-O']
['Injectable-O', 'lorazepam-B-Chemical']
['Transvenous-O', 'right-O', 'ventricular-O', 'pacing-O', 'during-O', 'cardiopulmonary-O', 'resuscitation-O', 'of-O', 'pediatric-O', 'patients-O', 'with-O', 'acute-B-Disease', 'cardiomyopathy-I-Disease', '.-O']
['We-O', 'describe-O', 'the-O', 'cardiopulmonary-O', 'resuscitation-O', 'efforts-O', 'on-O', 'five-O', 'patients-O', 'who-O', 'presented-O', 'in-O', 'acute-B-Disease', 'circulatory-O', 'failure-I-Disease', 'from-O', 'myocardial-B-Disease', 'dysfunction-I-Disease', '.-O']
['Three-O', 'patients-O', 'had-O', 'acute-O', 'viral-B-Disease', 'myocarditis-B-Disease', ',-O', 'one-O', 'had-O', 'a-O', 'carbamazepine-B-Chemical', ',-O', 'induced-O', 'acute-O', 'eosinophilic-B-Disease', 'myocarditis-B-Disease', ',-O', 'and-O', 'one-O', 'had-O', 'cardiac-O', 'hemosiderosis-B-Disease', 'resulting-O', 'in-O', 'acute-O', 'cardiogenic-B-Disease', 'shock-B-Disease', '.-O']
['All-O', 'patients-O', 'were-O', 'continuously-O', 'monitored-O', 'with-O', 'central-O', 'venous-O', 'and-O', 'arterial-O', 'catheters-O', 'in-O', 'addition-O', 'to-O', 'routine-O', 'noninvasive-O', 'monitoring-O', '.-O']
['An-O', 'introducer-O', 'sheath-O', ',-O', 'a-O', 'pacemaker-O', ',-O', 'and-O', 'sterile-O', 'pacing-O', 'wires-O', 'were-O', 'made-O', 'readily-O', 'available-O', 'for-O', 'the-O', 'patients-O', ',-O', 'should-O', 'the-O', 'need-O', 'arise-O', 'to-O', 'terminate-O', 'resistant-O', 'cardiac-B-Disease', 'dysrhythmias-I-Disease', '.-O']
['All-O', 'patients-O', 'developed-O', 'cardiocirculatory-O', 'arrest-I-Disease', 'associated-O', 'with-O', 'extreme-O', 'hypotension-B-Disease', 'and-O', 'dysrhythmias-B-Disease', 'within-O', 'the-O', 'first-O', '48-O', 'hours-O', 'of-O', 'their-O', 'admission-O', 'to-O', 'the-O', 'pediatric-O', 'intensive-O', 'care-O', 'unit-O', '(-O', 'PICU-O', ').-O', 'Right-O', 'ventricular-O', 'pacemaker-O', 'wires-O', 'were-O', 'inserted-O', 'in-O', 'all-O', 'of-O', 'them-O', 'during-O', 'cardiopulmonary-O', 'resuscitation-O', '(-O', 'CPR-O', ').-O', 'In-O', 'four-O', 'patients-O', ',-O', 'cardiac-O', 'pacing-O', 'was-O', 'used-O', ',-O', 'resulting-O', 'in-O', 'a-O', 'temporary-O', 'captured-O', 'rhythm-O', 'and-O', 'restoration-O', 'of-O', 'their-O', 'cardiac-O', 'output-O', '.-O']
['These-O', 'patients-O', 'had-O', 'a-O', 'second-O', 'event-O', 'of-O', 'cardiac-B-Disease', 'arrest-I-Disease', ',-O', 'resulting-O', 'in-O', 'death-B-Disease', ',-O', 'within-O', '10-O', 'to-O', '60-O', 'minutes-O', '.-O']
['In-O', 'one-O', 'patient-O', ',-O', 'cardiac-O', 'pacing-O', 'was-O', 'not-O', 'used-O', ',-O', 'because-O', 'he-O', 'converted-O', 'to-O', 'normal-O', 'sinus-B-Disease', 'rhythm-O', 'by-O', 'electrical-O', 'defibrillation-O', 'within-O', 'three-O', 'minutes-O', 'of-O', 'initiating-O', 'CPR-O', '.-O']
['We-O', 'conclude-O', 'that-O', 'cardiac-O', 'pacing-O', 'during-O', 'resuscitative-O', 'efforts-O', 'in-O', 'pediatric-O', 'patients-O', 'suffering-O', 'from-O', 'acute-O', 'myocardial-B-Disease', 'dysfunction-I-Disease']
['Efficacy-O', 'and-O', 'safety-O', 'of-O', 'granisetron-B-Chemical', ',-O', 'a-O', 'selective-O', '5-hydroxytryptamine-B-Chemical', ',-O', '3-O', 'receptor-O', 'antagonist-O', ',-O', 'in-O', 'the-O', 'prevention-O', 'of-O', 'nausea-B-Disease', 'and-O', 'vomiting-B-Disease', 'induced-O', 'by-O', 'high-O', ',-O', 'dose-O', 'cisplatin-B-Chemical', '.-O']
['PURPOSE-O', ':-O', 'To-O', 'assess-O', 'the-O', 'antiemetic-O', 'effects-O', 'and-O', 'safety-O', 'profile-O', 'of-O', 'four-O', 'different-O', 'doses-O', 'of-O', 'granisetron-B-Chemical', '(-O', 'Kytril-I-Chemical', ';-O', 'SmithKline-O', 'Beecham-O', 'Pharmaceuticals-O', ',-O', 'Philadelphia-O', ',-O', 'PA-O', ')-O', 'when-O', 'administered-O', 'as-O', 'a-O', 'single-O', 'intravenous-O', '(-O', 'IV-O', ')-O', 'dose-O', 'for-O', 'prophylaxis-O', 'of-O', 'cisplatin-B-Chemical', ',-O', 'induced-O', 'nausea-B-Disease', 'and-O', 'vomiting-B-Disease', '.-O']
['PATIENTS-O', 'AND-O', 'METHODS-O', ':', 'One-O', 'hundred-O', 'eighty-O', ',', 'four-O', 'chemotherapy-O', ',', 'naive-O', 'patients-O', 'receiving-O', 'high-O', ',', 'dose-O', 'cisplatin-B-Chemical', '(-O', '81-O', 'to-O', '120-O', 'mg-O', '/-O', 'm2-O', ')', 'were-O', 'randomized-O', 'to-O', 'receive-O', 'one-O', 'of-O', 'four-O', 'granisetron-B-Chemical', 'doses-O', '(-O', '5-O', ',', '10-O', ',', '20-O', ',', 'or-O', '40-O', 'micrograms-O', '/-O', 'kg-O', ')', 'administered-O', 'before-O', 'chemotherapy-O', '.-O']
['Patients-O', 'were-O', 'observed-O', 'on-O', 'an-O', 'inpatient-O', 'basis-O', 'for-O', '18-O', 'to-O', '24-O', 'hours-O', ',-O', 'and-O', 'vital-O', 'signs-O', ',-O', 'nausea-B-Disease', ',-O', 'vomiting-B-Disease', ',-O', 'retching-B-Disease', ',-O', 'and-O', 'appetite-O', 'were-O', 'assessed-O', '.-O']
['Safety-O', 'analyses-O', 'included-O', 'incidence-O', 'of-O', 'adverse-O', 'experiences-O', 'and-O', 'laboratory-O', 'parameter-O', 'changes-O', '.-O']
['RESULTS-O', ':-O', 'After-O', 'granisetron-B-Chemical', 'doses-O', 'of-O', '5-O', ',-O', '10-O', ',-O', '20-O', ',-O', 'and-O', '40-O', 'micrograms-O', '/-O', 'kg-O', ',-O', 'a-O', 'major-O', 'response-O', '(-O', '<-O', 'or-O', '=-O', 'two-O', 'vomiting-B-Disease', 'or-O', 'retching-B-Disease', 'episodes-O', ',-O', 'and-O', 'no-O', 'antiemetic-O', 'rescue-O', ')-O', 'was-O', 'recorded-O', 'in-O', '23-O', ',-O', '57-O', ',-O', '58-O', ',-O', 'and-O', '60-O', '%-O', 'of-O', 'patients-O', ',-O', 'respectively-O', ',-O', 'and-O', 'a-O', 'complete-O', 'response-O', '(-O', 'no-O', 'vomiting-B-Disease', 'or-O', 'retching-B-Disease', ',-O', 'and-O', 'no-O', 'antiemetic-O', 'rescue-O', ')-O', 'in-O', '18-O', ',-O', '41-O', ',-O', '40-O', ',-O', 'and-O', '47-O', '%-O', 'of-O', 'patients-O', ',-O', 'respectively-O', '.-O']
['There-O', 'was-O', 'a-O', 'statistically-O', 'longer-O', 'time-O', 'to-O', 'first-O', 'episode-O', 'of-O', 'nausea-B-Disease', '(-O', 'P-O', '=-O', '.0015-O', ')-O', 'and-O', 'vomiting-B-Disease', '(-O', 'P-O', '=-O', '.0001-O', ')-O', ',', 'and-O', 'fewer-O', 'patients-O', 'were-O', 'administered-O', 'additional-O', 'antiemetic-O', 'medication-O', 'in-O', 'the-O', '10-O', '-O', 'micrograms-O', '/-O', 'kg-O', 'dosing-O', 'groups-O', 'than-O', 'in-O', 'the-O', '5-O', '-O', 'micrograms-O', '/-O', 'kg-O', 'dosing-O', 'group-O', '.-O']
['As-O', 'granisetron-B-Chemical', 'dose-O', 'increased-O', ',-O', 'appetite-O', 'return-O', 'increased-O', '(-O', 'P-O', '=.-O', '040-O', ')-O', '.-O', 'Headache-B-Disease', 'was-O', 'the-O', 'most-O', 'frequently-O', 'reported-O', 'adverse-O', 'event-O', '(-O', '20-O', ')-O', '.-O', 'CONCLUSION-O', ':', 'A-O', 'single-O', '10-O', ',-O', '20-O', ',-O', 'or-O', '40-O', ',-O', 'micrograms-O', '/-O', 'kg-O', 'dose-O', 'of-O', 'granisetron-B-Chemical', 'was-O', 'effective-O', 'in-O', 'controlling-O', 'vomiting-B-Disease', 'in-O', '57-O', '%-O', 'to-O', '60-O', '%-O', 'of-O', 'patients-O', 'who-O', 'received-O', 'cisplatin-B-Chemical', 'at-O', 'doses-O', 'greater-O', 'than-O', '81-O', 'mg-O', '/-O', 'm2-O', 'and-O', 'totally-O', 'prevented-O', 'vomiting-B-Disease', 'in-O', '40-O', '%-O', 'to-O', '47-O', '%-O', 'of-O', 'patients-O', '.-O']
['There-O', 'were-O', 'no-O', 'statistically-O', 'significant-O', 'differences-O', 'in-O', 'efficacy-O', 'between-O', 'the-O', '10-O', ',-O', 'micrograms-O', '/-O', 'kg-O', 'dose-O', 'and-O', 'the-O', '20-O', ',-O', 'and-O', '40-O', ',-O', 'micrograms-O', '/-O', 'kg-O', 'doses-O', '.-O']
['Granisetron-B-Chemical']
['Adverse-O', 'interaction-O', 'between-O', 'clonidine-B-Chemical', 'and-O', 'verapamil-B-Chemical', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'report-O', 'two-O', 'cases-O', 'of-O', 'a-O', 'possible-O', 'adverse-O', 'interaction-O', 'between-O', 'clonidine-B-Chemical', 'and-O', 'verapamil-B-Chemical', 'resulting-O', 'in-O', 'atrioventricular-O', '(AV)-O', 'block-B-Disease', 'in-O', 'both-O', 'patients-O', 'and-O', 'severe-O', 'hypotension-B-Disease', 'in-O', 'one-O', 'patient-O', '.-O']
['CASE-O', 'SUMMARIES-O', ':-O', 'A-O', '54-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'with-O', 'hyperaldosteronism-B-Disease', 'was-O', 'treated-O', 'with-O', 'verapamil-B-Chemical', '480-O', 'mg-O', '/-O', 'd-O', 'and-O', 'spironolactone-B-Chemical', '100-O', 'mg-O', '/-O', 'd-O', '.-O']
['After-O', 'the-O', 'addition-O', 'of-O', 'a-O', 'minimal-O', 'dose-O', 'of-O', 'clonidine-B-Chemical', '(-O', '0-O', '.-O']
['15-O', 'mg-O', 'bid-O', ')-O', 'she-O', 'developed-O', 'complete-O', 'AV-B-Disease', 'block-I-Disease', 'and-O', 'severe-O', 'hypotension-B-Disease', ',-O', 'which-O', 'resolved-O', 'upon-O', 'cessation-O', 'of-O', 'all-O', 'medications-O', '.-O']
['A-O', '65-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'was-O', 'treated-O', 'with-O', 'extended-O', ',-O', 'release-O', 'verapamil-B-Chemical', '240-O', 'mg-O', '/-O', 'd-O', '.-O']
['After-O', 'the-O', 'addition-O', 'of-O', 'clonidine-B-Chemical', '0-O', '.-O']
['15-O', 'mg-O', 'bid-O', 'she-O', 'developed-O', 'complete-O', 'AV-B-Disease', 'block-I-Disease', ',-O', 'which-O', 'resolved-O', 'after-O', 'all-O', 'therapy-O', 'was-O', 'stopped-O', '.-O']
['DISCUSSION-O', ':-O', 'An-O', 'adverse-O', 'interaction-O', 'between-O', 'clonidine-B-Chemical', 'and-O', 'verapamil-B-Chemical', 'has-O', 'not-O', 'been-O', 'reported-O', 'previously-O', '.-O']
['We-O', 'describe-O', 'two-O', 'such-O', 'cases-O', 'and-O', 'discuss-O', 'the-O', 'various-O', 'mechanisms-O', 'that-O', 'might-O', 'cause-O', 'such-O', 'an-O', 'interaction-O', '.-O']
['Clinicians-O', 'should-O', 'be-O', 'acquainted-O', 'with-O', 'this-O', 'possibly-O', 'fatal-O', 'interaction-O', 'between-O', 'two-O', 'commonly-O', 'used-O', 'antihypertensive-O', 'drugs-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Caution-O', 'is-O', 'recommended-O', 'in-O', 'combining-O', 'clonidine-B-Chemical', 'and-O', 'verapamil-B-Chemical']
['Pharmacological-O', 'studies-O', 'on-O', 'a-O', 'new-O', 'dihydrothienopyridine-O', 'calcium-B-Chemical', 'antagonist-O', ',-O', 'S-312-d-B-Chemical', '.-O']
['5th-O', 'communication-O', ':-O', 'anticonvulsant-O', 'effects-O', 'in-O', 'mice-O', '.-O']
['S-312-B-Chemical', ',-O', 'S-312-d-B-Chemical', ',-O', 'but-O', 'not-O', 'S-312-l-B-Chemical', ',-O', 'L-O', 'type-O', 'calcium-B-Chemical', 'channel-O', 'antagonists-O', ',-O', 'showed-O', 'anticonvulsant-O', 'effects-O', 'on-O', 'the-O', 'audiogenic-O', 'tonic-O', 'convulsions-B-Disease', 'in-O', 'DBA-O', '/-O', '2-O', 'mice-O', ';-O', 'and-O', 'their-O', 'ED50-O', 'values-O', 'were-O', '18-O', '.-O']
['4-O', '(-O', '12-O', '.-O']
['8-O', ',-O', '27-O', '.-O']
['1-O', ')-O', 'mg-O', '/-O', 'kg-O', ',-O', 'p-O', '.-O']
['o-O', '.-O']
['and-O', '15-O', '.-O']
['0-O', '(-O', '10-O', '.-O']
['2-O', ',-O', '23-O', '.-O']
['7-O', ')-O', 'mg-O', '/-O', 'kg-O', ',-O', 'p-O', '.-O']
['o-O', '.-O', 'respectively-O', ',-O', 'while-O', 'that-O', 'of-O', 'flunarizine-B-Chemical', 'was-O', '34-O', '.-O']
['0-O', '(-O', '26-O', '.-O']
['0-O', ',-O', '44-O', '.-O']
['8-O', ')-O', 'mg-O', '/-O', 'kg-O', ',-O', 'p-O', '.-O']
['o-O', '.-O']
['Although-O', 'moderate-O', 'anticonvulsant-O', 'effects-O', 'of-O', 'S-312-d-B-Chemical', 'in-O', 'higher-O', 'doses-O', 'were-O', 'observed-O', 'against-O', 'the-O', 'clonic-B-Disease', 'convulsions-B-Disease', 'induced-O', 'by-O', 'pentylenetetrazole-B-Chemical', '(-O', '85-O', 'mg-O', '/-O', 'kg-O', ',-O', 's-O', '.-O']
['c-O', ')-O', 'or-O', 'bemegride-B-Chemical', '(-O', '40-O', 'mg-O', '/-O', 'kg-O', ',-O', 's-O', '.-O']
['c-O', '),-O', 'no-O', 'effects-O', 'were-O', 'observed-O', 'in-O', 'convulsions-B-Disease', 'induced-O', 'by-O', 'N-methyl-D-aspartate-B-Chemical', ',-O', 'picrotoxin-B-Chemical', ',-O', 'or-O', 'electroshock-O', 'in-O', 'Slc-O', ':-O', 'ddY-O', 'mice-O', '.-O']
['S-312-d-B-Chemical', 'may-O', 'be-O', 'useful-O', 'in-O', 'the-O', 'therapy-O', 'of-O', 'certain-O', 'types-O', 'of-O', 'human-O', 'epilepsy-B-Disease']
['Transmural-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'with-O', 'sumatriptan-B-Chemical', '.-O']
['For-O', 'sumatriptan-B-Chemical', ',-O', 'tightness-O', 'in-O', 'the-O', 'chest-B-Disease', 'caused-O', 'by-O', 'an-O', 'unknown-O', 'mechanism-O', 'has-O', 'been-O', 'reported-O', 'in-O', '3-O', ',', '5-O', '%-O', 'of-O', 'users-O', '.-O']
['We-O', 'describe-O', 'a-O', '47-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'with-O', 'an-O', 'acute-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'after-O', 'administration-O', 'of-O', 'sumatriptan-B-Chemical', '6-O', 'mg-O', 'subcutaneously-O', 'for-O', 'cluster-B-Disease', 'headache-I-Disease', '.-O']
['The-O', 'patient-O', 'had-O', 'no-O', 'history-O', 'of-O', 'underlying-O', 'ischaemic-B-Disease', 'heart-O', 'disease-I-Disease', 'or-O', 'Prinzmetal"s-B-Disease', 'angina-I-Disease']
['Flumazenil-B-Chemical', 'induces-O', 'seizures-B-Disease', 'and-O', 'death-B-Disease', 'in-O', 'mixed-O', 'cocaine-B-Chemical', ',-O', 'diazepam-B-Chemical', 'intoxications-O', '.-O']
['STUDY-O', 'HYPOTHESIS-O', ':-O', 'Administration-O', 'of-O', 'the-O', 'benzodiazepine-B-Chemical', 'antagonist-O', 'flumazenil-B-Chemical', 'may-O', 'unmask-O', 'seizures-B-Disease', 'in-O', 'mixed-O', 'cocaine-B-Chemical', ',-O', 'benzodiazepine-B-Chemical', 'intoxication-O', '.-O']
['DESIGN-O', ':-O', 'Male-O', 'Sprague-O', ',-O', 'Dawley-O', 'rats-O', 'received-O', '100-O', 'mg-O', '/-O', 'kg-O', 'cocaine-B-Chemical', 'IP-O', 'alone-O', ',-O', '5-O', 'mg-O', '/-O', 'kg-O', 'diazepam-B-Chemical', 'alone-O', ',-O', 'or-O', 'a-O', 'combination-O', 'of-O', 'diazepam-B-Chemical', 'and-O', 'cocaine-B-Chemical', '.-O']
['Three-O', 'minutes-O', 'later-O', ',-O', 'groups-O', 'were-O', 'challenged-O', 'with-O', 'vehicle-O', 'or-O', 'flumazenil-B-Chemical', '5-O', 'or-O', '10-O', 'mg-O', '/-O', 'kg-O', 'IP-O', '.-O']
['Animal-O', 'behavior-O', ',-O', 'seizures-B-Disease', '(-O', 'time-O', 'to-O', 'and-O', 'incidence-O', ')-O', 'death-B-Disease', '(-O', 'time-O', 'to-O', 'and-O', 'incidence-O', ')-O', 'and-O', 'cortical-O', 'EEG-O', 'tracings-O', 'were-O', 'recorded-O', '.-O']
['INTERVENTIONS-O', ':-O', 'Administration-O', 'of-O', 'flumazenil-B-Chemical', 'to-O', 'animals-O', 'after-O', 'they-O', 'had-O', 'received-O', 'a-O', 'combination-O', 'dose-O', 'of-O', 'cocaine-B-Chemical', 'and-O', 'diazepam-B-Chemical', '.-O']
['RESULTS-O', ':-O', 'In-O', 'group-O', '1-O', ',-O', 'animals-O', 'received-O', 'cocaine-B-Chemical', 'followed-O', 'by-O', 'vehicle-O', '.-O']
['This-O', 'resulted-O', 'in-O', '100-O', '%-O', 'developing-O', 'seizures-B-Disease', 'and-O', 'death-B-Disease', '.-O']
['Group-O', '2-O', 'received-O', 'diazepam-B-Chemical', 'alone-O', 'followed-O', 'by-O', 'vehicle-O', '.-O']
['Animals-O', 'became-O', 'somnolent-O', 'and-O', 'none-O', 'died-O', '.-O']
['Group-O', '3-O', 'received-O', 'diazepam-B-Chemical', 'followed-O', 'by-O', '5-O', 'mg-O', '/-O', 'kg-O', 'flumazenil-B-Chemical', '.-O']
['Animals-O', 'became-O', 'somnolent-O', 'after-O', 'diazepam-B-Chemical', 'and-O', 'then-O', 'active-O', 'after-O', 'flumazenil-B-Chemical', 'administration-O', '.-O']
['In-O', 'group-O', '4-O', ',-O', 'a-O', 'combination-O', 'of-O', 'cocaine-B-Chemical', 'and-O', 'diazepam-B-Chemical', 'was-O', 'administered-O', 'simultaneously-O', '.-O']
['This-O', 'resulted-O', 'in-O', 'no-O', 'overt-O', 'or-O', 'EEG-O', ',-O', 'detectable-O', 'seizures-B-Disease', 'and-O', 'a-O', '50-O', '%-O', 'incidence-O', 'of-O', 'death-B-Disease', '.-O']
['Group-O', '5-O', 'received-O', 'a-O', 'similar-O', 'combination-O', 'of-O', 'cocaine-B-Chemical', 'and-O', 'diazepam-B-Chemical', ',-O', 'followed-O', 'later-O', 'by-O', '5-O', 'mg-O', '/-O', 'kg-O', 'flumazenil-B-Chemical', '.-O']
['This-O', 'resulted-O', 'in-O', 'an-O', 'increased-O', 'incidence-O', 'of-O', 'seizures-B-Disease', ',-O', '90-O', '(-O', 'P-O', '<.-O', '01-O', ')-O', 'and-O', 'death-B-Disease', ',-O', '100-O', '(-O', 'P-O', '<-O', 'or-O', '=-O', '.-O', '01-O', ')-O', 'compared-O', 'with-O', 'group-O', '4-O', '.-O']
['Group-O', '6-O', 'received-O', 'cocaine-B-Chemical', 'and-O', 'diazepam-B-Chemical', 'followed-O', 'by-O', '10-O', 'mg-O', '/-O', 'kg-O', 'flumazenil-B-Chemical', '.-O']
['This-O', 'also-O', 'resulted-O', 'in-O', 'an-O', 'increased-O', 'incidence-O', 'of-O', 'seizures-B-Disease', ',-O', '90-O', '(-O', 'P-O', '<-O', 'or-O', '=-O', '.-O', '01-O', ')-O', ',', 'and-O', 'death-B-Disease', ',-O', '90-O', '(-O', 'P-O', '<-O', 'or-O', '=-O', '.-O', '05-O', ')-O', ',', 'compared-O', 'with-O', 'group-O', '4-O', '.-O']
['CONCLUSION-O', ':-O', 'Flumazenil-B-Chemical', 'can-O', 'unmask-O', 'seizures-B-Disease', 'and-O', 'increase-O', 'the-O', 'incidence-O', 'of-O', 'death-B-Disease', 'in-O', 'a-O', 'model-O', 'of-O', 'combined-O', 'cocaine-B-Chemical', ',-O', 'diazepam-B-Chemical']
['Mechanisms-O', 'for-O', 'protective-O', 'effects-O', 'of-O', 'free-O', 'radical-O', 'scavengers-O', 'on-O', 'gentamicin-B-Chemical', ',-O', 'mediated-O', 'nephropathy-B-Disease', 'in-O', 'rats-O', '.-O']
['Studies-O', 'were-O', 'performed-O', 'to-O', 'examine-O', 'the-O', 'mechanisms-O', 'for-O', 'the-O', 'protective-O', 'effects-O', 'of-O', 'free-O', 'radical-O', 'scavengers-O', 'on-O', 'gentamicin-B-Chemical', '(-O', 'GM-B-Chemical', ')-O', 'mediated-O', 'nephropathy-B-Disease', '.-O']
['Administration-O', 'of-O', 'GM-B-Chemical', 'at-O', '40-O', 'mg-O', '/-O', 'kg-O', 'sc-O', 'for-O', '13-O', 'days-O', 'to-O', 'rats-O', 'induced-O', 'a-O', 'significant-O', 'reduction-O', 'in-O', 'renal-O', 'blood-O', 'flow-O', '(-O', 'RBF-O', ')-O', 'and-O', 'inulin-B-Chemical', 'clearance-O', '(-O', 'CIn-O', ')-O', 'as-O', 'well-O', 'as-O', 'marked-O', 'tubular-O', 'damage-O', '.-O']
['A-O', 'significant-O', 'reduction-O', 'in-O', 'urinary-O', 'guanosine-B-Chemical', '3-O', '5\'-cyclic-O', 'monophosphate-O', '(-O', 'cGMP-B-Chemical', ')', 'excretion-O', 'and-O', 'a-O', 'significant-O', 'increase-O', 'in-O', 'renal-O', 'cortical-O', 'renin-O', 'and-O', 'endothelin-B-Chemical', '-O', '1-O', 'contents-O', 'were-O', 'also-O', 'observed-O', 'in-O', 'GM-O', '-O', 'mediated-O', 'nephropathy-B-Disease', '.-O']
['Superoxide-B-Chemical', 'dismutase-O', '(-O', 'SOD-B-Chemical', ')', 'or-O', 'dimethylthiourea-B-Chemical', '(-O', 'DMTU-B-Chemical', ')', 'significantly-O', 'lessened-O', 'the-O', 'GM-B-Chemical', ',-O', 'induced-O', 'decrement-O', 'in-O', 'CIn-O', '.-O']
['The-O', 'SOD-O', ',-O', 'induced-O', 'increase-O', 'in-O', 'glomerular-O', 'filtration-O', 'rate-O', 'was-O', 'associated-O', 'with-O', 'a-O', 'marked-O', 'improvement-O', 'in-O', 'RBF-O', ',-O', 'an-O', 'increase-O', 'in-O', 'urinary-O', 'cGMP-B-Chemical', 'excretion-O', ',-O', 'and-O', 'a-O', 'decrease-O', 'in-O', 'renal-O', 'renin-O', 'and-O', 'endothelin-B-Chemical', ',-O', '1-O', 'content-O', '.-O']
['SOD-B-Chemical', 'did-O', 'not-O', 'attenuate-O', 'the-O', 'tubular-O', 'damage-O', '.-O']
['In-O', 'contrast-O', ',-O', 'DMTU-B-Chemical', 'significantly-O', 'reduced-O', 'the-O', 'tubular-O', 'damage-O', 'and-O', 'lipid-O', 'peroxidation-O', ',-O', 'but-O', 'it-O', 'did-O', 'not-O', 'affect-O', 'renal-O', 'hemodynamics-O', 'and-O', 'vasoactive-O', 'substances-O', '.-O']
['Neither-O', 'SOD-B-Chemical', 'nor-O', 'DMTU-B-Chemical', 'affected-O', 'the-O', 'renal-O', 'cortical-O', 'GM-B-Chemical', 'content-O', 'in-O', 'GM-B-Chemical', ',-O', 'treated-O', 'rats-O', '.-O']
['These-O', 'results-O', 'suggest-O', 'that-O', '1-O', ')-O', 'both-O', 'SOD-B-Chemical', 'and-O', 'DMTU-B-Chemical', 'have-O', 'protective-O', 'effects-O', 'on-O', 'GM-B-Chemical', '-O', 'mediated-O', 'nephropathy-B-Disease', '-O', '2-O', ')-O', 'the-O', 'mechanisms-O', 'for-O', 'the-O', 'protective-O', 'effects-O', 'differ-O', 'for-O', 'SOD-B-Chemical', 'and-O', 'DMTU-B-Chemical', '-O', 'and-O', '3-O', ')-O', 'superoxide-O', 'anions-O', 'play-O', 'a-O', 'critical-O', 'role-O', 'in-O', 'GM-B-Chemical', 'nephrotoxicity-B-Disease']
['Assessment-O', 'of-O', 'cardiomyocyte-O', 'DNA-O', 'synthesis-O', 'during-O', 'hypertrophy-B-Disease', 'in-O', 'adult-O', 'mice-O', '.-O']
['The-O', 'ability-O', 'of-O', 'cardiomyocytes-O', 'to-O', 'synthesize-O', 'DNA-O', 'in-O', 'response-O', 'to-O', 'experimentally-O', 'induced-O', 'cardiac-B-Disease', 'hypertrophy-I-Disease', 'was-O', 'assessed-O', 'in-O', 'adult-O', 'mice-O', '.-O']
['Isoproterenol-B-Chemical', 'delivered-O', 'by-O', 'osmotic-O', 'minipump-O', 'implantation-O', 'in-O', 'adult-O', 'C3Heb-O', '/-O', 'FeJ-O', 'mice-O', 'resulted-O', 'in-O', 'a-O', '46-O', '%-O', 'increase-O', 'in-O', 'heart-O', 'weight-O', 'and-O', 'a-O', '19-O', '.-O']
['3-O', '%-O', 'increase-O', 'in-O', 'cardiomyocyte-O', 'area-O', '.-O']
['No-O', 'DNA-O', 'synthesis-O', ',-O', 'as-O', 'assessed-O', 'by-O', 'autoradiographic-O', 'analysis-O', 'of-O', 'isolated-O', 'cardiomyocytes-O', ',-O', 'was-O', 'observed-O', 'in-O', 'control-O', 'or-O', 'hypertrophic-B-Disease', 'hearts-O', '.-O']
['A-O', 'survey-O', 'of-O', '15-O', 'independent-O', 'inbred-O', 'strains-O', 'of-O', 'mice-O', 'revealed-O', 'that-O', 'ventricular-O', 'cardiomyocyte-O', 'nuclear-O', 'number-O', 'ranged-O', 'from-O', '3-O', 'to-O', '13-O', '%-O', 'mononucleate-O', ',-O', 'suggesting-O', 'that-O', 'cardiomyocyte-O', 'terminal-O', 'differentiation-O', 'is-O', 'influenced-O', 'directly-O', 'or-O', 'indirectly-O', 'by-O', 'genetic-O', 'background-O', '.-O']
['To-O', 'determine-O', 'whether-O', 'the-O', 'capacity-O', 'for-O', 'reactive-O', 'DNA-O', 'synthesis-O', 'was-O', 'also-O', 'subject-O', 'to-O', 'genetic-O', 'regulation-O', ',-O', 'cardiac-B-Disease', 'hypertrophy-I-Disease', 'was-O', 'induced-O', 'in-O', 'the-O', 'strains-O', 'of-O', 'mice-O', 'comprising-O', 'the-O', 'extremes-O', 'of-O', 'the-O', 'nuclear-O', 'number-O', 'survey-O', '.-O']
['These-O', 'data-O', 'indicate-O', 'that-O', 'adult-O', 'mouse-O', 'atrial-O', 'and-O', 'ventricular-O', 'cardiomyocytes-O', 'do-O', 'not-O', 'synthesize-O', 'DNA-O', 'in-O', 'response-O', 'to-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'cardiac-B-Disease', 'hypertrophy-I-Disease']
['Central-O', 'cardiovascular-O', 'effects-O', 'of-O', 'AVP-B-Chemical', 'and-O', 'ANP-B-Chemical', 'in-O', 'normotensive-O', 'and-O', 'spontaneously-O', 'hypertensive-B-Disease', 'rats-O', '.-O']
['The-O', 'purpose-O', 'of-O', 'the-O', 'present-O', 'study-O', 'was-O', 'to-O', 'compare-O', 'influence-O', 'of-O', 'central-O', 'arginine-B-Chemical', 'vasopressin-B-Chemical', '(-O', 'AVP-B-Chemical', ')-O', 'and-O', 'of-O', 'atrial-O', 'natriuretic-O', 'peptide-B-Chemical', '(-O', 'ANP-B-Chemical', ')-O', 'on-O', 'control-O', 'of-O', 'arterial-O', 'blood-O', 'pressure-O', '(-O', 'MAP-O', ')-O', 'and-O', 'heart-O', 'rate-O', '(-O', 'HR-O', ')-O', 'in-O', 'normotensive-O', '(-O', 'WKY-O', ')-O', 'and-O', 'spontaneously-O', 'hypertensive-B-Disease', '(-O', 'SHR-O', ')-O', 'rats-O', '.-O']
['Three-O', 'series-O', 'of-O', 'experiments-O', 'were-O', 'performed-O', 'on-O', '30-O', 'WKY-O', 'and-O', '30-O', 'SHR-O', ',-O', 'chronically-O', 'instrumented-O', 'with-O', 'guide-O', 'tubes-O', 'in-O', 'the-O', 'lateral-O', 'ventricle-O', '(-O', 'LV-O', ')-O', 'and-O', 'arterial-O', 'and-O', 'venous-O', 'catheters-O', '.-O']
['MAP-O', 'and-O', 'HR-O', 'were-O', 'monitored-O', 'before-O', 'and-O', 'after-O', 'i-O', '.-O']
['v-O', '.-O']
['injections-O', 'of-O', 'either-O', 'vehicle-O', 'or-O', '1-O', ',-O', '10-O', 'and-O', '50-O', 'ng-O', 'of-O', 'AVP-B-Chemical', 'and-O', '25-O', ',-O', '125-O', 'and-O', '500-O', 'ng-O', 'of-O', 'ANP-B-Chemical', '.-O']
['Sensitivity-O', 'of-O', 'cardiac-O', 'component-O', 'of-O', 'baroreflex-O', '(-O', 'CCB-O', ')-O', 'expressed-O', 'as-O', 'a-O', 'slope-O', 'of-O', 'the-O', 'regression-O', 'line-O', 'was-O', 'determined-O', 'from-O', 'relationships-O', 'between-O', 'systolic-O', 'arterial-O', 'pressure-O', '(-O', 'SAP-O', ')-O', 'and-O', 'HR-O', 'period-O', '(-O', 'HRp-O', ')-O', 'during-O', 'phenylephrine-B-Chemical', '(-O', 'Phe-B-Chemical', ')-O', 'induced-O', 'hypertension-B-Disease', 'and-O', 'sodium-B-Chemical', 'nitroprusside-I-Chemical', '(-O', 'SN-B-Chemical', ')-O', 'induced-O', 'hypotension-B-Disease', '.-O']
['CCB-O', 'was-O', 'measured-O', 'before-O', 'and-O', 'after-O', 'administration-O', 'of-O', 'either-O', 'vehicle-O', ',-O', 'AVP-B-Chemical', ',-O', 'ANP-B-Chemical', ',-O', 'or-O', 'both-O', 'peptides-O', 'together-O', '.-O']
['Increases-O', 'of-O', 'MAP-O', 'occurred-O', 'after-O', 'LV-O', 'administration-O', 'of-O', '1-O', ',-O', '10-O', 'and-O', '50-O', 'ng-O', 'of-O', 'AVP-B-Chemical', 'in-O', 'WKY-O', 'and-O', 'of-O', '10-O', 'and-O', '50-O', 'ng-O', 'in-O', 'SHR-O', '.-O']
['ANP-B-Chemical', 'did-O', 'not-O', 'cause-O', 'significant-O', 'changes-O', 'in-O', 'MAP-O', 'in-O', 'both-O', 'strains-O', 'as-O', 'compared-O', 'to-O', 'vehicle-O', ',-O', 'but-O', 'it-O', 'abolished-O', 'AVP-B-Chemical', ',-O', 'induced-O', 'MAP-O', 'increase-O', 'in-O', 'WKY-O', 'and-O', 'SHR-O', '.-O']
['CCB-O', 'was-O', 'reduced-O', 'in-O', 'WKY-O', 'and-O', 'SHR-O', 'after-O', 'LV-O', 'administration-O', 'of-O', 'AVP-B-Chemical', 'during-O', 'SN-O', ',-O', 'induced-O', 'hypotension-B-Disease', '.-O']
['In-O', 'SHR-O', 'but-O', 'not-O', 'in-O', 'WKY-O', 'administration-O', 'of-O', 'ANP-B-Chemical', ',-O', 'AVP-B-Chemical', 'and-O', 'ANP-B-Chemical', '+-O', 'AVP-B-Chemical', 'decreased-O', 'CCB-O', 'during-O', 'Phe-O', ',-O', 'induced-O', 'MAP-O', 'elevation-O', '.-O']
['The-O', 'results-O', 'indicate-O', 'that-O', 'centrally-O', 'applied-O', 'AVP-B-Chemical']
['Cutaneous-O', 'exposure-O', 'to-O', 'warfarin-B-Chemical', ',-O', 'like-O', 'anticoagulant-O', 'causing-O', 'an-O', 'intracerebral-B-Disease', 'hemorrhage-I-Disease', ':-O', 'a-O', 'case-O', 'report-O', '.-O']
['A-O', 'case-O', 'of-O', 'intercerebral-B-Disease', 'hematoma-B-Disease', 'due-O', 'to-O', 'warfarin-B-Chemical', ',-O', 'induced-O', 'coagulopathy-B-Disease', 'is-O', 'presented-O', '.-O']
['The-O', '39-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'had-O', 'spread-O', 'a-O', 'warfarin-B-Chemical', ',-O', 'type-O', 'rat-O', 'poison-O', 'around-O', 'her-O', 'house-O', 'weekly-O', 'using-O', 'her-O', 'bare-O', 'hands-O', ',-O', 'with-O', 'no-O', 'washing-O', 'post-O', 'application-O', '.-O']
['Percutaneous-O', 'absorption-O', 'of-O', 'warfarin-B-Chemical', 'causing-O', 'coagulopathy-B-Disease', ',-O', 'reported-O', 'three-O', 'times-O', 'in-O', 'the-O', 'past-O', ',-O', 'is-O', 'a-O', 'significant-O', 'risk-O', 'if-O', 'protective-O', 'measures-O', ',-O', 'such-O', 'as-O', 'gloves-O', ',-O', 'are-O', 'not-O', 'used-O', '.-O']
['An-O', 'adverse-O', 'drug-O', 'interaction-O', 'with-O', 'piroxicam-B-Chemical', ',-O', 'which-O', 'she-O', 'took-O', 'occasionally-O', ',-O', 'may-O', 'have-O', 'exacerbated-O', 'the-O', 'coagulopathy-B-Disease']
['Pediatric-O', 'heart-B-Disease', 'transplantation-O', 'without-O', 'chronic-O', 'maintenance-O', 'steroids-B-Chemical', '.-O']
['From-O', '1986-O', 'to-O', 'February-O', '1993-O', ',-O', '40-O', 'children-O', 'aged-O', '2-O', 'months-O', 'to-O', '18-O', 'years-O', '(-O', 'average-O', 'age-O', '10-O', '.-O']
['4-O', '+-O', '5-O', '.-O']
['8-O', 'years-O', ')-O', 'underwent-O', 'heart-O', 'transplantation-O', '.-O']
['Indications-O', 'for-O', 'transplantation-O', 'were-O', 'idiopathic-B-Disease', 'cardiomyopathy-I-Disease', '(-O', '52-O', ')-O', 'congenital-B-Disease', 'heart-O', 'disease-I-Disease', '(-O', '35-O', ')-O', 'with-O', 'and-O', 'without-O', 'prior-O', 'repair-O', '(-O', '71-O', '%-O', 'and-O', '29-O', ',-O', 'respectively-O', ')-O', 'hypertrophic-B-Disease', 'cardiomyopathy-I-Disease', '(-O', '5-O', ')-O', 'valvular-B-Disease', 'heart-O', 'disease-I-Disease', '(-O', '3-O', ')-O', 'and-O', 'doxorubicin-B-Chemical', 'cardiomyopathy-I-Disease', '(-O', '5-O', ')-O', '.-O', 'Patients-O', 'were-O', 'managed-O', 'with-O', 'cyclosporine-B-Chemical', 'and-O', 'azathioprine-B-Chemical', '.-O']
['No-O', 'prophylaxis-O', 'with-O', 'antilymphocyte-B-Chemical', 'globulin-I-Chemical', 'was-O', 'used-O', '.-O']
['Steroids-B-Chemical', 'were-O', 'given-O', 'to-O', '39-O', '%-O', 'of-O', 'patients-O', 'for-O', 'refractory-O', 'rejection-O', ',-O', 'but-O', 'weaning-O', 'was-O', 'always-O', 'attempted-O', 'and-O', 'generally-O', 'successful-O', '(-O', '64-O', ').-O', 'Five-O', 'patients-O', '(-O', '14-O', ')-O', 'received-O', 'maintenance-O', 'steroids-B-Chemical', '.-O']
['Four-O', 'patients-O', 'died-O', 'in-O', 'the-O', 'perioperative-O', 'period-O', 'and-O', 'one-O', 'died-O', '4-O', 'months-O', 'later-O', '.-O']
['There-O', 'have-O', 'been-O', 'no-O', 'deaths-B-Disease', 'related-O', 'to-O', 'rejection-O', 'or-O', 'infection-B-Disease', '.-O']
['Average-O', 'follow-O', ',-O', 'up-O', 'was-O', '36-O', '+-O', '19-O', 'months-O', '(-O', 'range-O', '1-O', 'to-O', '65-O', 'months-O', ').-O', 'Cumulative-O', 'survival-O', 'is-O', '88-O', '%-O', 'at-O', '5-O', 'years-O', '.-O']
['In-O', 'patients-O', 'less-O', 'than-O', '7-O', 'years-O', 'of-O', 'age-O', ',-O', 'rejection-B-Disease', 'was-O', 'monitored-O', 'noninvasively-O', '.-O']
['In-O', 'the-O', 'first-O', 'postoperative-O', 'month-O', ',-O', '89-O', '%-O', 'of-O', 'patients-O', 'were-O', 'treated-O', 'for-O', 'rejection-B-Disease', '.-O']
['Freedom-O', 'from-O', 'serious-O', 'infections-B-Disease', 'was-O', '83-O', '%-O', 'at-O', '1-O', 'month-O', 'and-O', '65-O', '%-O', 'at-O', '1-O', 'year-O', '.-O']
['Cytomegalovirus-B-Disease', 'infections-I-Disease', 'were-O', 'treated-O', 'successfully-O', 'with-O', 'ganciclovir-B-Chemical', 'in-O', '11-O', 'patients-O', '.-O']
['No-O', 'impairment-O', 'of-O', 'growth-O', 'was-O', 'observed-O', 'in-O', 'children-O', 'who-O', 'underwent-O', 'transplantation-O', 'compared-O', 'with-O', 'a-O', 'control-O', 'population-O', '.-O']
['Twenty-O', ',-O', 'one-O', 'patients-O', '(-O', '60-O', ')-O', 'have-O', 'undergone-O', 'annual-O', 'catheterizations-O', 'and-O', 'no-O', 'sign-O', 'of-O', 'graft-O', 'atherosclerosis-B-Disease', 'has-O', 'been-O', 'observed-O', '.-O']
['Seizures-B-Disease', 'occurred-O', 'in-O', 'five-O', 'patients-O', '(-O', '14-O', ')-O', 'and-O', 'hypertension-B-Disease', 'was-O', 'treated-O', 'in-O', '10-O', 'patients-O', '(-O', '28-O', ')-O', '.-O', 'No-O', 'patient-O', 'was-O', 'disabled-O', 'and-O', 'no-O', 'lymphoproliferative-B-Disease', 'disorder-O']
['Delirium-B-Disease', 'during-O', 'fluoxetine-B-Chemical', 'treatment-O', '.-O']
['A-O', 'case-O', 'report-O', '.-O']
['The-O', 'correlation-O', 'between-O', 'high-O', 'serum-O', 'tricyclic-O', 'antidepressant-B-Chemical', 'concentrations-O', 'and-O', 'central-O', 'nervous-O', 'system-O', 'side-O', 'effects-O', 'has-O', 'been-O', 'well-O', 'established-O', '.-O']
['Only-O', 'a-O', 'few-O', 'reports-O', 'exist-O', ',-O', 'however-O', ',-O', 'on-O', 'the-O', 'relationship-O', 'between-O', 'the-O', 'serum-O', 'concentrations-O', 'of-O', 'selective-O', 'serotonin-B-Chemical', 'reuptake-I-Chemical', 'inhibitors-I-Chemical', '(-O', 'SSRIs-B-Chemical', ')-O', 'and-O', 'their-O', 'toxic-O', 'effects-O', '.-O']
['In-O', 'some-O', 'cases-O', ',-O', 'a-O', 'high-O', 'serum-O', 'concentration-O', 'of-O', 'citalopram-B-Chemical', '(>-O', '600-O', 'nmol-O', '/', 'L-O', ')-O', 'in-O', 'elderly-O', 'patients-O', 'has-O', 'been-O', 'associated-O', 'with-O', 'increased-O', 'somnolence-B-Disease', 'and-O', 'movement-O', 'difficulties-B-Disease', '.-O']
['Widespread-O', 'cognitive-O', 'disorders-O', ',-O', 'such-O', 'as-O', 'delirium-B-Disease', ',-O', 'have-O', 'not-O', 'been-O', 'previously-O', 'linked-O', 'with-O', 'high-O', 'blood-O', 'levels-O', 'of-O', 'SSRIs-B-Chemical', '.-O']
['In-O', 'this-O', 'report-O', ',-O', 'we-O', 'describe-O', 'a-O', 'patient-O', 'with-O', 'acute-O', 'hyperkinetic-O', 'delirium-B-Disease', 'connected-O', 'with-O', 'a-O', 'high-O', 'serum-O', 'total-O', 'fluoxetine-B-Chemical', '(-O', 'fluoxetine-B-Chemical', 'plus-O', 'desmethylfluoxetine-B-Chemical']
['Pulmonary-B-Disease', 'edema-I-Disease', 'and-O', 'shock-B-Disease', 'after-O', 'high-O', ',-O', 'dose-O', 'aracytine-C-B-Chemical', 'for-O', 'lymphoma-I-Disease', ';-O', 'possible-O', 'role-O', 'of-O', 'TNF-B-Chemical', ',-O', 'alpha-O', 'and-O', 'PAF-B-Chemical', '.-O']
['Four-O', 'out-O', 'of-O', '23-O', 'consecutive-O', 'patients-O', 'treated-O', 'with-O', 'high-O', ',-O', 'dose-O', 'Ara-C-B-Chemical', 'for-O', 'lymphomas-B-Disease', 'in-O', 'our-O', 'institution-O', 'developed-O', 'a-O', 'strikingly-O', 'similar-O', 'syndrome-O', 'during-O', 'the-O', 'perfusion-O', '.-O']
['It-O', 'was-O', 'characterized-O', 'by-O', 'the-O', 'onset-O', 'of-O', 'fever-B-Disease', ',-O', 'diarrhea-B-Disease', ',-O', 'shock-B-Disease', ',-O', 'pulmonary-B-Disease', 'edema-I-Disease', ',-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', ',-O', 'metabolic-B-Disease', 'acidosis-I-Disease', ',-O', 'weight-O', 'gain-O', 'and-O', 'leukocytosis-B-Disease', '.-O']
['Thorough-O', 'bacteriological-O', 'screening-O', 'failed-O', 'to-O', 'provide-O', 'evidence-O', 'of-O', 'infection-B-Disease', '.-O']
['Sequential-O', 'biological-O', 'assays-O', 'of-O', 'IL-B-Chemical', ',-O', '1-O', ',-O', 'IL-B-Chemical', ',-O', '2-O', ',-O', 'TNF-B-Chemical', 'and-O', 'PAF-B-Chemical', 'were-O', 'performed-O', 'during-O', 'Ara-C-B-Chemical', 'infusion-O', 'to-O', 'ten-O', 'patients-O', ',-O', 'including-O', 'the-O', 'four-O', 'who-O', 'developed-O', 'the-O', 'syndrome-O', '.-O']
['TNF-O', 'and-O', 'PAF-B-Chemical', 'activity-O', 'was-O', 'found-O', 'in-O', 'the-O', 'serum-O', 'of-O', 'respectively-O', 'two-O', 'and-O', 'four-O', 'of-O', 'the-O', 'cases-O', ',-O', 'but-O', 'not-O', 'in-O', 'the-O', 'six-O', 'controls-O', '.-O']
['As-O', 'TNF-B-Chemical', 'and-O', 'PAF-B-Chemical', 'are-O', 'thought-O', 'to-O', 'be-O', 'involved-O', 'in-O', 'the-O', 'development-O', 'of-O', 'septic-B-Disease', 'shock-I-Disease', 'and-O', 'adult-O', 'respiratory-B-Disease', 'distress-O', 'syndrome-O', ',-O', 'we-O', 'hypothesize-O', 'that-O', 'high-O', ',-O', 'dose-O', 'Ara-C-B-Chemical']
['Protective-O', 'effect-O', 'of-O', 'clentiazem-B-Chemical', 'against-O', 'epinephrine-B-Chemical', ',-O', 'induced-O', 'cardiac-O', 'injury-O', 'in-O', 'rats-O', '.-O']
['We-O', 'investigated-O', 'the-O', 'effects-O', 'of-O', 'clentiazem-B-Chemical', ',-O', 'a-O', '1,5-benzothiazepine-O', 'calcium-B-Chemical', 'antagonist-O', ',-O', 'on-O', 'epinephrine-B-Chemical', ',-O', 'induced-O', 'cardiomyopathy-B-Disease', 'in-O', 'rats-O', '.-O']
['With-O', '2-O', ',-O', 'week-O', 'chronic-O', 'epinephrine-B-Chemical', 'infusion-O', ',-O', '16-O', 'of-O', '30-O', 'rats-O', 'died-O', 'within-O', '4-O', 'days-O', ',-O', 'and-O', 'severe-O', 'ischemic-B-Disease', 'lesions-O', 'and-O', 'fibrosis-B-Disease', 'of-O', 'the-O', 'left-O', 'ventricles-O', 'were-O', 'observed-O', '.-O']
['In-O', 'epinephrine-B-Chemical', ',-O', 'treated-O', 'rats-O', ',-O', 'left-O', 'atrial-O', 'and-O', 'left-O', 'ventricular-O', 'papillary-O', 'muscle-O', 'contractile-O', 'responses-O', 'to-O', 'isoproterenol-B-Chemical', 'were-O', 'reduced-O', ',-O', 'but-O', 'responses-O', 'to-O', 'calcium-B-Chemical', 'were-O', 'normal-O', 'or-O', 'enhanced-O', 'compared-O', 'to-O', 'controls-O', '.-O']
['Left-O', 'ventricular-O', 'alpha-O', 'and-O', 'beta-O', 'adrenoceptor-O', 'densities-O', 'were-O', 'also-O', 'reduced-O', 'compared-O', 'to-O', 'controls-O', '.-O']
['Treatment-O', 'with-O', 'clentiazem-B-Chemical', 'prevented-O', 'epinephrine-B-Chemical', ',-O', 'induced-O', 'death-B-Disease', '(-O', 'P-O', '<.-O', '05-O', ')-O', 'and-O', 'attenuated-O', 'the-O', 'ventricular-B-Disease', 'ischemic-B-Disease', 'lesions-B-Disease', 'and-O', 'fibrosis-B-Disease', ',-O', 'in-O', 'a-O', 'dose-O', ',-O', 'dependent-O', 'manner-O', '.-O']
['Left-O', 'atrial-O', 'and-O', 'left-O', 'ventricular-O', 'papillary-O', 'muscle-O', 'contractile-O', 'responses-O', 'to-O', 'isoproterenol-B-Chemical', 'were-O', 'reduced-O', 'compared-O', 'to-O', 'controls-O', 'in-O', 'groups-O', 'treated-O', 'with-O', 'clentiazem-B-Chemical', 'alone-O', ',-O', 'but-O', 'combined-O', 'with-O', 'epinephrine-B-Chemical', ',-O', 'clentiazem-B-Chemical', 'restored-O', 'left-O', 'atrial-O', 'responses-O', 'and-O', 'enhanced-O', 'left-O', 'ventricular-O', 'papillary-O', 'responses-O', 'to-O', 'isoproterenol-B-Chemical', '.-O']
['On-O', 'the-O', 'other-O', 'hand-O', 'clentiazem-B-Chemical', 'did-O', 'not-O', 'prevent-O', 'epinephrine-B-Chemical', ',-O', 'induced-O', 'down-O', '--O', 'regulation-O', 'of-O', 'alpha-O', 'and-O', 'beta-O', 'adrenoceptors-O', '.-O']
['Interestingly-O', ',-O', 'clentiazem-B-Chemical', ',-O', 'infused-O', 'alone-O', ',-O', 'resulted-O', 'in-O', 'decreased-O', 'adrenergic-O', 'receptor-O', 'densities-O', 'in-O', 'the-O', 'left-O', 'ventricle-O', '.-O']
['Clentiazem-B-Chemical', 'also-O', 'did-O', 'not-O', 'prevent-O', 'the-O', 'enhanced-O', 'responses-O', 'to-O', 'calcium-B-Chemical', 'seen-O', 'in-O', 'the-O', 'epinephrine-B-Chemical', ',-O', 'treated-O', 'animals-O', ',-O', 'although-O', 'the-O', 'high-O', 'dose-O', 'of-O', 'clentiazem-B-Chemical', 'partially-O', 'attenuated-O', 'the-O', 'maximal-O', 'response-O', 'to-O', 'calcium-B-Chemical', 'compared-O', 'to-O', 'epinephrine-B-Chemical', ',-O', 'treated-O', 'animals-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'clentiazem-B-Chemical', 'attenuated-O', 'epinephrine-B-Chemical', ',-O', 'induced-O', 'cardiac-B-Disease', 'injury-I-Disease']
['Cocaine-B-Chemical', 'induced-O', 'myocardial-B-Disease', 'ischemia-I-Disease', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'myocardial-B-Disease', 'ischemia-I-Disease', 'induced-O', 'by-O', 'cocaine-B-Chemical', '.-O']
['The-O', 'ischemia-B-Disease', 'probably-O', 'induced-O', 'by-O', 'coronary-B-Disease', 'artery-O', 'spasm-I-Disease', 'was-O', 'reversed-O', 'by-O', 'nitroglycerin-B-Chemical', 'and-O', 'calcium-B-Chemical']
['Doxorubicin-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', 'monitored-O', 'by-O', 'ECG-O', 'in-O', 'freely-O', 'moving-O', 'mice-O', '.-O']
['A-O', 'new-O', 'model-O', 'to-O', 'test-O', 'potential-O', 'protectors-O', '.-O']
['In-O', 'laboratory-O', 'animals-O', ',-O', 'histology-O', 'is-O', 'most-O', 'commonly-O', 'used-O', 'to-O', 'study-O', 'doxorubicin-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', '.-O']
['However-O', ',-O', 'for-O', 'monitoring-O', 'during-O', 'treatment-O', ',-O', 'large-O', 'numbers-O', 'of-O', 'animals-O', 'are-O', 'needed-O', '.-O']
['Recently-O', 'we-O', 'developed-O', 'a-O', 'new-O', 'method-O', 'to-O', 'measure-O', 'ECG-O', 'values-O', 'in-O', 'freely-O', 'moving-O', 'mice-O', 'by-O', 'telemetry-O', '.-O']
['With-O', 'this-O', 'model-O', 'we-O', 'investigated-O', 'the-O', 'effect-O', 'of-O', 'chronic-O', 'doxorubicin-B-Chemical', 'administration-O', 'on-O', 'the-O', 'ECG-O', 'of-O', 'freely-O', 'moving-O', 'BALB-O', '/-O', 'c-O', 'mice-O', 'and-O', 'the-O', 'efficacy-O', 'of-O', 'ICRF-187-B-Chemical', 'as-O', 'a-O', 'protective-O', 'agent-O', '.-O']
['The-O', 'ST-O', 'interval-O', 'significantly-O', 'widened-O', 'from-O', '15-O', '.-O']
['0-O', '+-O', '1-O', '.-O']
['5-O', 'to-O', '56-O', '.-O']
['8-O', '+-O', '11-O', '.-O']
['8-O', 'ms-O', 'in-O', 'week-O', '10-O', '(-O', '7-O', 'weekly-O', 'doses-O', 'of-O', '4-O', 'mg-O', '/-O', 'kg-O', 'doxorubicin-B-Chemical', 'given-O', 'i-O', '.-O']
['v-O', '.-O']
['plus-O', '3-O', 'weeks-O', 'of-O', 'observation-O', ')-O', 'The-O', 'ECG-O', 'of-O', 'the-O', 'control-O', 'animals-O', 'did-O', 'not-O', 'change-O', 'during-O', 'the-O', 'entire-O', 'study-O', '.-O']
['After-O', 'sacrifice-O', 'the-O', 'hearts-O', 'of-O', 'doxorubicin-B-Chemical', ',-O', 'treated-O', 'animals-O', 'were-O', 'enlarged-O', 'and-O', 'the-O', 'atria-O', 'were-O', 'hypertrophic-O', '.-O']
['As-O', 'this-O', 'schedule-O', 'exerted-O', 'more-O', 'toxicity-B-Disease', 'than-O', 'needed-O', 'to-O', 'investigate-O', 'protective-O', 'agents-O', ',-O', 'the-O', 'protection-O', 'of-O', 'ICRF-187-B-Chemical', 'was-O', 'determined-O', 'using-O', 'a-O', 'dose-O', 'schedule-O', 'with-O', 'lower-O', 'general-O', 'toxicity-B-Disease', '(-O', '6-O', 'weekly-O', 'doses-O', 'of-O', '4-O', 'mg-O', '/-O', 'kg-O', 'doxorubicin-B-Chemical', 'given-O', 'i-O', '.-O']
['v-O', '.-O']
['plus-O', '2-O', 'weeks-O', 'of-O', 'observation-O', ').-O', 'On-O', 'this-O', 'schedule-O', ',-O', 'the-O', 'animals-O', 'x-O', 'hearts-O', 'appeared-O', 'normal-O', 'after-O', 'sacrifice-O', 'and-O', 'ICRF-187-B-Chemical', '(-O', '50-O', 'mg-O', '/-O', 'kg-O', 'given-O', 'i-O', '.-O']
['p-O', '.-O']
['1-O', 'h-O', 'before-O', 'doxorubicin-B-Chemical', ')-O', 'provided-O', 'almost-O', 'full-O', 'protection-O', '.-O']
['These-O', 'data-O', 'were-O', 'confirmed-O', 'by-O', 'histology-O', '.-O']
['The-O', 'results-O', 'indicate-O', 'that-O', 'this-O', 'new-O', 'model-O', 'is-O', 'very-O', 'sensitive-O', 'and-O', 'enables-O', 'monitoring-O', 'of-O', 'the-O', 'development-O', 'of-O', 'cardiotoxicity-B-Disease', 'with-O', 'time-O', '.-O']
['These-O', 'findings-O', 'result-O', 'in-O', 'a-O', 'model-O', 'that-O', 'allows-O', 'the-O', 'testing-O', 'of-O', 'protectors-O', 'against-O', 'doxorubicin-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', 'as-O', 'demonstrated-O', 'by-O', 'the-O', 'protection-O', 'provided-O', 'by-O', 'ICRF-187-B-Chemical']
['Epinephrine-B-Chemical', 'dysrhythmogenicity-O', 'is-O', 'not-O', 'enhanced-O', 'by-O', 'subtoxic-O', 'bupivacaine-B-Chemical', 'in-O', 'dogs-O', '.-O']
['Since-O', 'bupivacaine-B-Chemical', 'and-O', 'epinephrine-B-Chemical', 'may-O', 'both-O', 'precipitate-O', 'dysrhythmias-B-Disease', ',-O', 'circulating-O', 'bupivacaine-B-Chemical', 'during-O', 'regional-O', 'anesthesia-O', 'could-O', 'potentiate-O', 'dysrhythmogenic-O', 'effects-O', 'of-O', 'epinephrine-B-Chemical', '.-O']
['We-O', 'therefore-O', 'examined-O', 'whether-O', 'bupivacaine-B-Chemical', 'alters-O', 'the-O', 'dysrhythmogenicity-O', 'of-O', 'subsequent-O', 'administration-O', 'of-O', 'epinephrine-B-Chemical', 'in-O', 'conscious-O', ',-O', 'healthy-O', 'dogs-O', 'and-O', 'in-O', 'anesthetized-O', 'dogs-O', 'with-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['Forty-O', ',-O', 'one-O', 'conscious-O', 'dogs-O', 'received-O', '10-O', 'micrograms-O', '.-O']
['kg-O', ',-O', '1-O', '.-O']
['min-O', ',-O', '1-O', 'epinephrine-B-Chemical', '.-O']
['Seventeen-O', 'animals-O', 'responded-O', 'with-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', '(-O', 'VT-O', ')-O', 'within-O', '3-O', 'min-O', '.-O']
['After-O', '3-O', 'h-O', ',-O', 'these-O', 'responders-O', 'randomly-O', 'received-O', '1-O', 'or-O', '2-O', 'mg-O', '/-O', 'kg-O', 'bupivacaine-B-Chemical', 'or-O', 'saline-O', 'over-O', '5-O', 'min-O', ',-O', 'followed-O', 'by-O', '10-O', 'micrograms-O', '.-O']
['kg-O', ',-O', '1-O', '.-O']
['min-O', ',-O', '1-O', 'epinephrine-B-Chemical', '.-O']
['In-O', 'the-O', 'bupivacaine-B-Chemical', 'groups-O', ',-O', 'epinephrine-B-Chemical', 'caused-O', 'fewer-O', 'prodysrhythmic-O', 'effects-O', 'than-O', 'without-O', 'bupivacaine-B-Chemical', '.-O']
['VT-B-Disease', 'appeared-O', 'in-O', 'fewer-O', 'dogs-O', 'and-O', 'at-O', 'a-O', 'later-O', 'time-O', ',-O', 'and-O', 'there-O', 'were-O', 'more-O', 'sinoatrial-B-Disease', 'beats-O', 'and-O', 'less-O', 'ectopies-O', '.-O']
['Epinephrine-B-Chemical', 'shortened-O', 'QT-O', 'less-O', 'after-O', 'bupivacaine-B-Chemical', 'than-O', 'in-O', 'control-O', 'animals-O', '.-O']
['One-O', 'day-O', 'after-O', 'experimental-O', 'myocardial-B-Disease', 'infarction-I-Disease', ',-O', 'six-O', 'additional-O', 'halothane-B-Chemical', ',-O', 'anesthetized-O', 'dogs-O', 'received-O', '4-O', 'micrograms-O', '.-O']
['kg-O', ',-O', '1-O', '.-O']
['min-O', ',-O', '1-O', 'epinephrine-B-Chemical', 'until-O', 'VT-O', 'appeared-O', '.-O']
['After-O', '45-O', 'min-O', ',-O', '1-O', 'mg-O', '/-O', 'kg-O', 'bupivacaine-B-Chemical', 'was-O', 'injected-O', 'over-O', '5-O', 'min-O', ',-O', 'again-O', 'followed-O', 'by-O', '4-O', 'micrograms-O', '.-O']
['kg-O', ',-O', '1-O', '.-O']
['min-O', ',-O', '1-O', 'epinephrine-B-Chemical', '.-O']
['In-O', 'these-O', 'dogs-O', ',-O', 'the-O', 'prodysrhythmic-O', 'response-O', 'to-O', 'epinephrine-B-Chemical', 'was-O', 'also-O', 'mitigated-O', 'by-O', 'preceding-O', 'bupivacaine-B-Chemical', '.-O']
['Bupivacaine-B-Chemical', 'antagonizes-O', 'epinephrine-B-Chemical', 'dysrhythmogenicity-O', 'in-O', 'conscious-O', 'dogs-O', 'susceptible-O', 'to-O', 'VT-B-Disease', 'and-O', 'in-O', 'anesthetized-O', 'dogs-O', 'with-O', 'spontaneous-O', 'postinfarct-B-Disease', 'dysrhythmias-I-Disease', '.-O']
['There-O', 'is-O', 'no-O', 'evidence-O', 'that-O', 'systemic-O', 'subtoxic-O', 'bupivacaine-B-Chemical', 'administration-O', 'enhances-O', 'the-O', 'dysrhythmogenicity-B-Disease', 'of-O', 'subsequent-O', 'epinephrine-B-Chemical']
['Milk-alkali-O', 'syndrome-O', 'induced-O', 'by-O', '1,25(OH)2D-B-Chemical', 'in-O', 'a-O', 'patient-O', 'with-O', 'hypoparathyroidism-B-Disease', '.-O']
['Milk-alkali-B-Disease', 'syndrome-I-Disease', 'was-O', 'first-O', 'described-O', '70-O', 'years-O', 'ago-O', 'in-O', 'the-O', 'context-O', 'of-O', 'the-O', 'treatment-O', 'of-O', 'peptic-B-Disease', 'ulcer-I-Disease', 'disease-I-Disease', 'with-O', 'large-O', 'amounts-O', 'of-O', 'calcium-B-Chemical', 'and-O', 'alkali-O', '.-O']
['Although-O', 'with-O', 'current-O', 'ulcer-B-Disease', 'therapy-O', '(-O', 'H-O', ',-O', '2-O', 'blockers-O', ',-O', 'omeprazole-B-Chemical', ',-O', 'and-O', 'sucralfate-B-Chemical', '),-O', 'the-O', 'frequency-O', 'of-O', 'milk-alkali-B-Disease', 'syndrome-I-Disease', 'has-O', 'decreased-O', 'significantly-O', ',-O', 'the-O', 'classic-O', 'triad-O', 'of-O', 'hypercalcemia-B-Disease', ',-O', 'alkalosis-B-Disease', ',-O', 'and-O', 'renal-O', 'impairment-B-Disease', 'remains-O', 'the-O', 'hallmark-O', 'of-O', 'the-O', 'syndrome-O', '.-O']
['Milk-alkali-O', 'syndrome-B-Disease', 'can-O', 'present-O', 'serious-O', 'and-O', 'occasionally-O', 'life-O', ',-O', 'threatening-O', 'illness-I-Disease', 'unless-O', 'diagnosed-O', 'and-O', 'treated-O', 'appropriately-O', '.-O']
['This-O', 'article-O', 'presents-O', 'a-O', 'patient-O', 'with-O', 'hypoparathyroidism-B-Disease', 'who-O', 'was-O', 'treated-O', 'with-O', 'calcium-B-Chemical', 'carbonate-I-Chemical', 'and-O', 'calcitriol-B-Chemical', 'resulting-O', 'in-O', 'two-O', 'admissions-O', 'to-O', 'the-O', 'hospital-O', 'for-O', 'milk-alkali-O', 'syndrome-B-Disease', '.-O']
['The-O', 'patient-O', 'was-O', 'successfully-O', 'treated-O', 'with-O', 'intravenous-O', 'pamidronate-B-Chemical', 'on-O', 'his-O', 'first-O', 'admission-O', 'and-O', 'with-O', 'hydrocortisone-B-Chemical', 'on-O', 'the-O', 'second-O', '.-O']
['This-O', 'illustrates-O', 'intravenous-O', 'pamidronate-B-Chemical', 'as-O', 'a-O', 'valuable-O', 'therapeutic-O', 'tool-O', 'when-O', 'milk-alkali-B-Disease', 'syndrome-I-Disease', 'presents-O', 'as-O', 'hypercalcemic-B-Disease', 'emergency-O']
['Encephalopathy-B-Disease', 'during-O', 'amitriptyline-B-Chemical', 'therapy-O', ':-O', 'are-O', 'neuroleptic-B-Disease', 'malignant-O', 'syndrome-O', 'and-O', 'serotonin-B-Chemical', 'syndrome-O', 'spectrum-O', 'disorders-O', '?-O', 'This-O', 'report-O', 'describes-O', 'a-O', 'case-O', 'of-O', 'encephalopathy-B-Disease', 'developed-O', 'in-O', 'the-O', 'course-O', 'of-O', 'amitriptyline-B-Chemical', 'therapy-O', ',-O', 'during-O', 'a-O', 'remission-O', 'of-O', 'unipolar-B-Disease', 'depression-O', '.-O']
['This-O', 'patient-O', 'could-O', 'have-O', 'been-O', 'diagnosed-O', 'as-O', 'having-O', 'either-O', 'neuroleptic-B-Disease', 'malignant-I-Disease', 'syndrome-I-Disease', '(-O', 'NMS-B-Disease', ')-O', 'or-O', 'serotonin-B-Disease', 'syndrome-I-Disease', '(-O', 'SS-B-Disease', ')-O', '.', 'The-O', 'major-O', 'determinant-O', 'of-O', 'the-O', 'symptoms-O', 'may-O', 'have-O', 'been-O', 'dopamine-B-Chemical', '/', 'serotonin-B-Chemical', 'imbalance-O', 'in-O', 'the-O', 'central-O', 'nervous-O', 'system-O', '.-O']
['The-O', 'NMS-B-Disease', ',-O', 'like-O', 'encephalopathy-B-Disease', 'that-O', 'develops-O', 'in-O', 'association-O', 'with-O', 'the-O', 'use-O', 'of-O', 'antidepressants-B-Chemical', 'indicates-O', 'that-O', 'NMS-B-Disease', 'and-O', 'SS-O']
['Genetic-O', 'separation-O', 'of-O', 'tumor-B-Disease', 'growth-O', 'and-O', 'hemorrhagic-B-Disease', 'phenotypes-O', 'in-O', 'an-O', 'estrogen-B-Chemical', ',-O', 'induced-O', 'tumor-B-Disease', '.-O']
['Chronic-O', 'administration-O', 'of-O', 'estrogen-B-Chemical', 'to-O', 'the-O', 'Fischer-O', '344-O', '(-O', 'F344-O', ')-O', 'rat-O', 'induces-O', 'growth-O', 'of-O', 'large-O', ',-O', 'hemorrhagic-O', 'pituitary-B-Disease', 'tumors-I-Disease', '.-O']
['Ten-O', 'weeks-O', 'of-O', 'diethylstilbestrol-B-Chemical', '(-O', 'DES-B-Chemical', ')-O', 'treatment-O', 'caused-O', 'female-O', 'F344-O', 'rat-O', 'pituitaries-O', 'to-O', 'grow-O', 'to-O', 'an-O', 'average-O', 'of-O', '109-O', '.-O']
['2-O', '+-O', '6-O', '.-O']
['3-O', 'mg-O', '(-O', 'mean-O', '+-O', 'SE-O', ')-O', 'versus-O', '11-O', '.-O']
['3-O', '+-O', '1-O', '.-O']
['4-O', 'mg-O', 'for-O', 'untreated-O', 'rats-O', ',-O', 'and-O', 'to-O', 'become-O', 'highly-O', 'hemorrhagic-B-Disease', '.-O']
['The-O', 'same-O', 'DES-B-Chemical', 'treatment-O', 'produced-O', 'no-O', 'significant-O', 'growth-O', '(-O', '8-O', '.-O']
['9-O', '+-O', '0-O', '.-O']
['5-O', 'mg-O', 'for-O', 'treated-O', 'females-O', 'versus-O', '8-O', '.-O']
['7-O', '+-O', '1-O', '.-O']
['1-O', 'for-O', 'untreated-O', 'females-O', ')-O', 'or-O', 'morphological-O', 'changes-O', 'in-O', 'Brown-O', 'Norway-O', '(-O', 'BN-O', ')-O', 'rat-O', 'pituitaries-O', '.-O']
['An-O', 'F1-O', 'hybrid-O', 'of-O', 'F344-O', 'and-O', 'BN-O', 'exhibited-O', 'significant-O', 'pituitary-O', 'growth-O', 'after-O', '10-O', 'weeks-O', 'of-O', 'DES-B-Chemical', 'treatment-O', 'with-O', 'an-O', 'average-O', 'mass-O', 'of-O', '26-O', '.-O']
['3-O', '+-O', '0-O', '.-O']
['7-O', 'mg-O', 'compared-O', 'with-O', '8-O', '.-O']
['6-O', '+-O', '0-O', '.-O']
['9-O', 'mg-O', 'for-O', 'untreated-O', 'rats-O', '.-O']
['Surprisingly-O', ',-O', 'the-O', 'F1-O', 'hybrid-O', 'tumors-B-Disease', 'were-O', 'not-O', 'hemorrhagic-B-Disease', 'and-O', 'had-O', 'hemoglobin-O', 'content-O', 'and-O', 'outward-O', 'appearance-O', 'identical-O', 'to-O', 'that-O', 'of-O', 'BN-O', '.-O']
['Expression-O', 'of-O', 'both-O', 'growth-O', 'and-O', 'morphological-O', 'changes-O', 'is-O', 'due-O', 'to-O', 'multiple-O', 'genes-O', '.-O']
['However-O', ',-O', 'while-O', 'DES-B-Chemical', ',-O', 'induced-O', 'pituitary-B-Disease', 'growth-O', 'exhibited-O', 'quantitative-O', ',-O', 'additive-O', 'inheritance-O', ',-O', 'the-O', 'hemorrhagic-B-Disease', 'phenotype-O', 'exhibited-O', 'recessive-O', ',-O', 'epistatic-O', 'inheritance-O', '.-O']
['Only-O', '5-O', 'of-O', 'the-O', '160-O', 'F2-O', 'pituitaries-O', 'exhibited-O', 'the-O', 'hemorrhagic-B-Disease', 'phenotype-O', ';-O', '36-O', 'of-O', 'the-O', '160-O', 'F2-O', 'pituitaries-O', 'were-O', 'in-O', 'the-O', 'F344-O', 'range-O', 'of-O', 'mass-O', ',-O', 'but-O', '31-O', 'of-O', 'these-O', 'were-O', 'not-O', 'hemorrhagic-O', ',-O', 'indicating-O', 'that-O', 'the-O', 'hemorrhagic-B-Disease', 'phenotype-O', 'is-O', 'not-O', 'merely-O', 'a-O', 'consequence-O', 'of-O', 'extensive-O', 'growth-O', '.-O']
['The-O', 'hemorrhagic-B-Disease']
['Increased-O', 'expression-O', 'of-O', 'neuronal-O', 'nitric-B-Chemical', 'oxide-I-Chemical', 'synthase-O', 'in-O', 'bladder-O', 'afferent-O', 'pathways-O', 'following-O', 'chronic-O', 'bladder-O', 'irritation-O', '.-O']
['Immunocytochemical-O', 'techniques-O', 'were-O', 'used-O', 'to-O', 'examine-O', 'alterations-O', 'in-O', 'the-O', 'expression-O', 'of-O', 'neuronal-O', 'nitric-B-Chemical', 'oxide-I-Chemical', 'synthase-O', '(-O', 'NOS-O', ')-O', 'in-O', 'bladder-O', 'pathways-O', 'following-O', 'acute-O', 'and-O', 'chronic-O', 'irritation-O', 'of-O', 'the-O', 'urinary-O', 'tract-O', 'of-O', 'the-O', 'rat-O', '.-O']
['Chemical-O', 'cystitis-B-Disease', 'was-O', 'induced-O', 'by-O', 'cyclophosphamide-B-Chemical', '(-O', 'CYP-O', ')-O', 'which-O', 'is-O', 'metabolized-O', 'to-O', 'acrolein-B-Chemical', ',-O', 'an-O', 'irritant-O', 'eliminated-O', 'in-O', 'the-O', 'urine-O', '.-O']
['Injection-O', 'of-O', 'CYP-B-Chemical', '(-O', 'n-O', '=', '10-O', ',-O', '75-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', ')-O', '2-O', 'hours-O', 'prior-O', 'to-O', 'perfusion-O', '(-O', 'acute-O', 'treatment-O', ')-O', 'of-O', 'the-O', 'animals-O', 'increased-O', 'Fos-B-Chemical', ',-O', 'immunoreactivity-O', '(-O', 'IR-O', ')-O', 'in-O', 'neurons-O', 'in-O', 'the-O', 'dorsal-O', 'commissure-O', ',-O', 'dorsal-O', 'horn-O', ',-O', 'and-O', 'autonomic-O', 'regions-O', 'of-O', 'spinal-O', 'segments-O', '(-O', 'L1-O', ',-O', 'L2-O', 'and-O', 'L6-O', ',-O', 'S1-O', ')-O', 'which-O', 'receive-O', 'afferent-O', 'inputs-O', 'from-O', 'the-O', 'bladder-O', ',-O', 'urethra-O', ',-O', 'and-O', 'ureter-O', '.-O']
['Fos-O', ',-O', 'IR-O', 'in-O', 'the-O', 'spinal-O', 'cord-O', 'was-O', 'not-O', 'changed-O', 'in-O', 'rats-O', 'receiving-O', 'chronic-O', 'CYP-O', 'treatment-O', '(-O', 'n-O', '=', '15-O', ',-O', '75-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', '.,-O', 'every-O', '3rd-O', 'day-O', 'for-O', '2-O', 'weeks-O', ')-O', '.-O', 'In-O', 'control-O', 'animals-O', 'and-O', 'in-O', 'animals-O', 'treated-O', 'acutely-O', 'with-O', 'CYP-B-Chemical', ',-O', 'only-O', 'small-O', 'numbers-O', 'of-O', 'NOS-B-Chemical', ',-O', 'IR-O', 'cells-O', '(-O', '0-O', '.-O']
['5-O', ',-O', '0-O', '.-O']
['7-O', 'cell-O', 'profiles-O', '/-O', 'sections-O', ')-O', 'were-O', 'detected-O', 'in-O', 'the-O', 'L6-O', '-O', 'S1-O', 'dorsal-O', 'root-O', 'ganglia-O', '(-O', 'DRG-O', ')-O', '.-O', 'Chronic-O', 'CYP-B-Chemical', 'administration-O', 'significantly-O', '(-O', 'P-O', '<-O', 'or-O', '=-O', '.-O', '002-O', ')-O', 'increased-O', 'bladder-O', 'weight-O', 'by-O', '60-O', '%-O', 'and-O', 'increased-O', '(-O', '7-O', '-O', 'to-O', '11-O', '-O', 'fold-O', ')-O', 'the-O', 'numbers-O', 'of-O', 'NOS-B-Chemical', '-O', 'immunoreactive-O', '(-O', 'IR-O', ')-O', 'afferent-O', 'neurons-O', 'in-O', 'the-O', 'L6-O', '-O', 'S1-O', 'DRG-O', '.-O']
['A-O', 'small-O', 'increase-O', '(-O', '1-O', '.-O']
['5-O', ',-O', 'fold-O', ')-O', 'also-O', 'occurred-O', 'in-O', 'the-O', 'L1-O', 'DRG-O', ',-O', 'but-O', 'no-O', 'change-O', 'was-O', 'detected-O', 'in-O', 'the-O', 'L2-O', 'and-O', 'L5-O', 'DRG-O', '.-O']
['Bladder-O', 'afferent-O', 'cells-O', 'in-O', 'the-O', 'L6-O', ',-O', 'S1-O', 'DRG-O', 'labeled-O', 'by-O', 'Fluorogold-B-Chemical', '(-O', '40-O', 'microliters-O', ')-O', 'injected-O', 'into-O', 'the-O', 'bladder-O', 'wall-O', 'did-O', 'not-O', 'exhibit-O', 'NOS-O', ',-O', 'IR-O', 'in-O', 'control-O', 'animals-O', ';-O', 'however-O', ',-O', 'following-O', 'chronic-O', 'CYP-B-Chemical']
['Effects-O', 'of-O', 'a-O', 'new-O', 'calcium-B-Chemical', 'antagonist-O', ',-O', 'CD-832-B-Chemical', ',-O', 'on-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'myocardial-B-Disease', 'ischemia-I-Disease', 'in-O', 'dogs-O', 'with-O', 'partial-O', 'coronary-O', 'stenosis-I-Disease', '.-O']
['Effects-O', 'of-O', 'CD-832-B-Chemical', 'on-O', 'isoproterenol-B-Chemical', '(-O', 'ISO-B-Chemical', ')-O', 'induced-O', 'myocardial-B-Disease', 'ischemia-I-Disease', 'were-O', 'studied-O', 'in-O', 'dogs-O', 'with-O', 'partial-O', 'coronary-O', 'stenosis-I-Disease', 'of-O', 'the-O', 'left-O', 'circumflex-O', 'coronary-O', 'artery-O', 'and-O', 'findings-O', 'were-O', 'compared-O', 'with-O', 'those-O', 'for-O', 'nifedipine-B-Chemical', 'or-O', 'diltiazem-B-Chemical', '.-O']
['In-O', 'the-O', 'presence-O', 'of-O', 'coronary-O', 'artery-O', 'stenosis-I-Disease', ',-O', '3-O', ',', 'min-O', 'periods-O', 'of-O', 'intracoronary-O', 'ISO-B-Chemical', 'infusion-O', '(-O', '10-O', 'ng-O', '/-O', 'kg-O', '/-O', 'min-O', ')-O', 'increased-O', 'heart-O', 'rate-O', 'and-O', 'maximal-O', 'rate-O', 'of-O', 'left-O', 'ventricular-O', 'pressure-O', 'rise-O', ',-O', 'which-O', 'resulted-O', 'in-O', 'a-O', 'decrease-O', 'in-O', 'percentage-O', 'segmental-O', 'shortening-O', 'and-O', 'ST-O', ',', 'segment-O', 'elevation-O', 'of-O', 'the-O', 'epicardial-O', 'electrocardiogram-O', '.-O']
['After-O', 'the-O', 'control-O', 'ISO-O', 'infusion-O', 'with-O', 'stenosis-B-Disease', 'was-O', 'performed-O', ',-O', 'equihypotensive-O', 'doses-O', 'of-O', 'CD-832-B-Chemical', '(-O', '3-O', 'and-O', '10-O', 'micrograms-O', '/-O', 'kg-O', '/-O', 'min-O', ',-O', 'n-O', '=O', '7-O', ')-O', 'nifedipine-B-Chemical', '(-O', '1-O', 'and-O', '3-O', 'micrograms-O', '/-O', 'kg-O', '/-O', 'min-O', ',-O', 'n-O', '=O', '9-O', ')-O', 'or-O', 'diltiazem-B-Chemical', '(-O', '10-O', 'and-O', '30-O', 'micrograms-O', '/-O', 'kg-O', '/-O', 'min-O', ',-O', 'n-O', '=O', '7-O', ')-O', 'were-O', 'infused-O', '5-O', 'min-O', 'before-O', 'and-O', 'during-O', 'the-O', 'second-O', 'and-O', 'third-O', 'ISO-O', 'infusion-O', '.-O']
['Both-O', 'CD-832-B-Chemical', 'and-O', 'diltiazem-B-Chemical', ',-O', 'but-O', 'not-O', 'nifedipine-B-Chemical', ',-O', 'significantly-O', 'reduced-O', 'the-O', 'increase-O', 'in-O', 'heart-O', 'rate-O', 'induced-O', 'by-O', 'ISO-B-Chemical', 'infusion-O', '.-O']
['In-O', 'contrast-O', 'to-O', 'nifedipine-B-Chemical', ',-O', 'CD-832-B-Chemical', '(-O', '10-O', 'micrograms-O', '/-O', 'kg-O', '/-O', 'min-O', ')-O', 'prevented-O', 'the-O', 'decrease-O', 'in-O', 'percentage-O', 'segmental-O', 'shortening-O', 'from-O', '32-O', '+-O', '12-O', '%-O', 'to-O', '115-O', '+-O', '26-O', '%-O', 'of-O', 'the-O', 'control-O', 'value-O', '(-O', 'P-O', '<.-O', '01-O', ')-O', 'and-O', 'ST-O', ',-O', 'segment-O', 'elevation-O', 'from-O', '5-O', '.-O']
['6-O', '+-O', '1-O', '.-O']
['0-O', 'mV-O', 'to-O', '1-O', '.-O']
['6-O', '+-O', '1-O', '.-O']
['3-O', 'mV-O', '(-O', 'P-O', '<.-O', '01-O', ')-O', 'at-O', '3-O', 'min-O', 'after-O', 'ISO-B-Chemical', 'infusion-O', 'with-O', 'stenosis-B-Disease', '.-O']
['Diltiazem-B-Chemical', '(-O', '30-O', 'micrograms-O', '/-O', 'kg-O', '/-O', 'min-O', ')-O', 'also-O', 'prevented-O', 'the-O', 'decrease-O', 'in-O', 'percentage-O', 'segmental-O', 'shortening-O', 'from-O', '34-O', '+-O', '14-O', '%-O', 'to-O', '63-O', '+-O', '18-O', '%-O', 'of-O', 'the-O', 'control-O', 'value-O', '(-O', 'P-O', '<.-O', '05-O', ')-O', 'and-O', 'ST-O', ',', 'segment-O', 'elevation-O', 'from-O', '4-O', '.-O']
['7-O', '+-O', '0-O', '.-O']
['7-O', 'mV-O', 'to-O', '2-O', '.-O']
['1-O', '+-O', '0-O', '.-O']
['7-O', 'mV-O', '(-O', 'P-O', '<.-O', '01-O', ')-O', 'at-O', '3-O', 'min-O', 'after-O', 'ISO-B-Chemical', 'infusion-O', 'with-O', 'stenosis-B-Disease', '.-O']
['These-O', 'data-O', 'show-O', 'that-O', 'CD-832-B-Chemical', 'improves-O', 'myocardial-B-Disease', 'ischemia-I-Disease', 'during-O', 'ISO-B-Chemical', 'infusion-O', 'with-O', 'stenosis-I-Disease', 'and-O', 'suggest-O', 'that-O', 'the-O', 'negative-O', 'chronotropic-O', 'property-O', 'of-O', 'CD-832-B-Chemical', 'plays-O', 'a-O', 'major-O', 'role-O', 'in-O', 'the-O', 'beneficial-O', 'effects-O', 'of-O', 'CD-832-B-Chemical']
['The-O', 'effect-O', 'of-O', 'recombinant-O', 'human-O', 'insulin-B-Chemical', ',-O', 'like-O', 'growth-O', 'factor-O', ',-O', 'I-O', 'on-O', 'chronic-O', 'puromycin-B-Chemical', 'aminonucleoside-I-Chemical', 'nephropathy-B-Disease', 'in-O', 'rats-O', '.-O']
['We-O', 'recently-O', 'demonstrated-O', 'that-O', 'recombinant-O', 'hGH-B-Chemical', 'exacerbates-O', 'renal-O', 'functional-O', 'and-O', 'structural-O', 'injury-O', 'in-O', 'chronic-O', 'puromycin-B-Chemical', 'aminonucleoside-I-Chemical', '(-O', 'PAN-B-Chemical', ')-O', 'nephropathy-B-Disease', ',-O', 'an-O', 'experimental-O', 'model-O', 'of-O', 'glomerular-O', 'disease-O', '.-O']
['Therefore-O', ',-O', 'we-O', 'examined-O', 'whether-O', 'recombinant-O', 'human-O', '(-O', 'rh-O', ')-O', 'IGF-B-Chemical', ',-O', 'I-O', 'is-O', 'a-O', 'safer-O', 'alternative-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'growth-O', 'failure-O', 'in-O', 'rats-O', 'with-O', 'chronic-O', 'PAN-B-Chemical', 'nephropathy-B-Disease', '.-O']
['The-O', 'glomerulopathy-B-Disease', 'was-O', 'induced-O', 'by-O', 'seven-O', 'serial-O', 'injections-O', 'of-O', 'PAN-B-Chemical', 'over-O', '12-O', 'wk-O', '.-O']
['Experimental-O', 'animals-O', '(-O', 'n-O', '=-O', '6-O', ')-O', 'received-O', 'rhIGF-B-Chemical', ',-O', 'I-O', ',-O', '400-O', 'micrograms-O', '/-O', 'd-O', ',-O', 'whereas-O', 'control-O', 'rats-O', '(-O', 'n-O', '=-O', '6-O', ')-O', 'received-O', 'the-O', 'vehicle-O', '.-O']
['rhIGF-B-Chemical', ',-O', 'I-O', 'improved-O', 'weight-B-Disease', 'gain-I-Disease', 'by-O', '14-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ')-O', 'without-O', 'altering-O', 'hematocrit-O', 'or-O', 'blood-O', 'pressure-O', 'in-O', 'rats-O', 'with-O', 'renal-B-Disease', 'disease-I-Disease', '.-O']
['Urinary-O', 'protein-O', 'excretion-O', 'was-O', 'unaltered-O', 'by-O', 'rhIGF-B-Chemical', ',-O', 'I-O', 'treatment-O', 'in-O', 'rats-O', 'with-O', 'chronic-O', 'PAN-B-Chemical', 'nephropathy-I-Disease', '.-O']
['After-O', '12-O', 'wk-O', ',-O', 'the-O', 'inulin-B-Chemical', 'clearance-O', 'was-O', 'higher-O', 'in-O', 'rhIGF-B-Chemical', ',-O', 'I-O', ',', 'treated-O', 'rats-O', ',-O', '0-O', '.-O']
['48-O', '+-O', '0-O', '.-O']
['08-O', 'versus-O', '0-O', '.-O']
['24-O', '+-O', '0-O', '.-O']
['06-O', 'mL-O', '/-O', 'min-O', '/-O', '100-O', 'g-O', 'of-O', 'body-O', 'weight-O', 'in-O', 'untreated-O', 'PAN-B-Chemical', 'nephropathy-B-Disease', 'animals-O', ',-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', '.-O']
['The-O', 'improvement-O', 'in-O', 'GFR-O', 'was-O', 'not-O', 'associated-O', 'with-O', 'enhanced-O', 'glomerular-O', 'hypertrophy-O', 'or-O', 'increased-O', 'segmental-O', 'glomerulosclerosis-I-Disease', ',-O', 'tubulointerstitial-O', 'injury-O', ',-O', 'or-O', 'renal-O', 'cortical-O', 'malondialdehyde-B-Chemical', 'content-O', '.-O']
['In-O', 'rats-O', 'with-O', 'PAN-B-Chemical', 'nephropathy-B-Disease', ',-O', 'administration-O', 'of-O', 'rhIGF-B-Chemical', ',-O', 'I-O', 'increased-O', 'IGF-O', ',-O', 'I-O', 'and-O', 'GH-O', 'receptor-O', 'gene-O', 'expression-O', ',-O', 'without-O', 'altering-O', 'the-O', 'steady-O', 'state-O', 'level-O', 'of-O', 'IGF-O', ',-O', 'I-O', 'receptor-O', 'mRNA-O', '.-O']
['In-O', 'normal-O', 'rats-O', 'with-O', 'intact-O', 'kidneys-O', ',-O', 'rhIGF-O', ',-O', 'I-O', 'administration-O', '(-O', 'n-O', '=-O', '4-O', ')-O', 'did-O', 'not-O', 'alter-O', 'weight-O', 'gain-O', ',-O', 'blood-O', 'pressure-O', ',-O', 'proteinuria-O', ',-O', 'GFR-O', ',-O', 'glomerular-O', 'planar-O', 'area-O', ',-O', 'renal-O', 'cortical-O', 'malondialdehyde-O', 'content-O', ',-O', 'or-O', 'glomerular-O', 'or-O', 'tubulointerstitial-O', 'damage-O', ',-O', 'compared-O', 'with-O', 'untreated-O', 'animals-O', '(-O', 'n-O', '=-O', '4-O', ')-O', '.-O', 'rhIGF-O', ',-O', 'I-O', 'treatment-O', 'reduced-O', 'the-O', 'steady-O', 'state-O', 'renal-O', 'IGF-O', ',-O', 'I-O', 'mRNA-O', 'level-O', 'but-O', 'did-O', 'not-O', 'modify-O', 'gene-O', 'expression-O', 'of-O', 'the-O', 'IGF-O', ',-O', 'I-O', 'or-O', 'GH-O', 'receptors-O', '.-O']
['We-O', 'conclude-O', 'that-O', ':-O', '1-O', ')-O', 'administration-O', 'of-O', 'rhIGF-B-Chemical', ',-O', 'I-O', 'improves-O', 'growth-O', 'and-O', 'GFR-O', 'in-O', 'rats-O', 'with-O', 'chronic-O', 'PAN-B-Chemical', 'nephropathy-B-Disease']
['Nefiracetam-B-Chemical', '(-O', 'DM-9384-O', ')-O', 'reverses-O', 'apomorphine-B-Chemical', ',-O', 'induced-O', 'amnesia-B-Disease', 'of-O', 'a-O', 'passive-O', 'avoidance-O', 'response-O', ':-O', 'delayed-O', 'emergence-O', 'of-O', 'the-O', 'memory-O', 'retention-O', 'effects-O', '.-O']
['Nefiracetam-B-Chemical', 'is-O', 'a-O', 'novel-O', 'pyrrolidone-B-Chemical', 'derivative-O', 'which-O', 'attenuates-O', 'scopolamine-B-Chemical', ',-O', 'induced-O', 'learning-O', 'and-O', 'post-training-O', 'consolidation-O', 'deficits-I-Disease', '.-O']
['Given-O', 'that-O', 'apomorphine-B-Chemical', 'inhibits-O', 'passive-O', 'avoidance-O', 'retention-O', 'when-O', 'given-O', 'during-O', 'training-O', 'or-O', 'in-O', 'a-O', 'defined-O', '10-O', ',-O', '12h-O', 'post-O', ',-O', 'training-O', 'period-O', ',-O', 'we-O', 'evaluated-O', 'the-O', 'ability-O', 'of-O', 'nefiracetam-B-Chemical', 'to-O', 'attenuate-O', 'amnesia-B-Disease', 'induced-O', 'by-O', 'dopaminergic-O', 'agonism-O', '.-O']
['A-O', 'step-O', ',-O', 'down-O', 'passive-O', 'avoidance-O', 'paradigm-O', 'was-O', 'employed-O', 'and-O', 'nefiracetam-B-Chemical', '(-O', '3-O', 'mg-O', '/-O', 'kg-O', ')-O', 'and-O', 'apomorphine-B-Chemical', '(-O', '0-O', '.-O']
['5-O', 'mg-O', '/-O', 'kg-O', ')-O', 'were-O', 'given-O', 'alone-O', 'or-O', 'in-O', 'combination-O', 'during-O', 'training-O', 'and-O', 'at-O', 'the-O', '10-O', ',-O', '12h-O', 'post-O', ',-O', 'training-O', 'period-O', 'of-O', 'consolidation-O', '.-O']
['Co-O', ',-O', 'administration-O', 'of-O', 'nefiracetam-B-Chemical', 'and-O', 'apomorphine-B-Chemical', 'during-O', 'training-O', 'or-O', '10h-O', 'thereafter-O', 'produced-O', 'no-O', 'significant-O', 'anti-O', ',-O', 'amnesic-B-Disease', 'effect-O', '.-O']
['However-O', ',-O', 'administration-O', 'of-O', 'nefiracetam-B-Chemical', 'during-O', 'training-O', 'completely-O', 'reversed-O', 'the-O', 'amnesia-B-Disease', 'induced-O', 'by-O', 'apomorphine-B-Chemical', 'at-O', 'the-O', '10h-O', 'post-O', ',-O', 'training-O', 'time-O', 'and-O', 'the-O', 'converse-O', 'was-O', 'also-O', 'true-O', '.-O']
['These-O', 'effects-O', 'were-O', 'not-O', 'mediated-O', 'by-O', 'a-O', 'dopaminergic-O', 'mechanism-O', 'as-O', 'nefiracetam-B-Chemical', ',-O', 'at-O', 'millimolar-O', 'concentrations-O', ',-O', 'failed-O', 'to-O', 'displace-O', 'either-O', '[', '3H-B-Chemical', ']', 'SCH-B-Chemical', '23390-B-Chemical', 'or-O', '[', '3H-B-Chemical', ']', 'spiperone-B-Chemical', 'binding-O', 'from-O', 'D1-O', 'or-O', 'D2-O', 'dopamine-B-Chemical', 'receptor-O', 'subtypes-O', ',-O', 'respectively-O', '.-O']
['It-O', 'is-O', 'suggested-O', 'that-O', 'nefiracetam-B-Chemical']
['Human-O', 'corticotropin-O', ',-O', 'releasing-O', 'hormone-O', 'and-O', 'thyrotropin-O', ',-O', 'releasing-O', 'hormone-O', 'modulate-O', 'the-O', 'hypercapnic-O', 'ventilatory-O', 'response-O', 'in-O', 'humans-O', '.-O']
['Human-O', 'corticotropin-O', ',-O', 'releasing-O', 'hormone-O', '(-O', 'hCRH-O', ')-O', 'and-O', 'thyrotropin-O', ',-O', 'releasing-O', 'hormone-O', '(-O', 'TRH-O', ')-O', 'are-O', 'known-O', 'to-O', 'stimulate-O', 'ventilation-O', 'after-O', 'i-O', '.-O']
['v-O', '.-O']
['administration-O', 'in-O', 'humans-O', '.-O']
['In-O', 'a-O', 'placebo-O', ',-O', 'controlled-O', ',-O', 'single-O', ',-O', 'blind-O', 'study-O', 'we-O', 'aimed-O', 'to-O', 'clarify-O', 'if-O', 'both-O', 'peptides-O', 'act-O', 'by-O', 'altering-O', 'central-O', 'chemosensitivity-O', '.-O']
['Two-O', 'subsequent-O', 'CO2-B-Chemical', ',-O', 'rebreathing-O', 'tests-O', 'were-O', 'performed-O', 'in-O', 'healthy-O', 'young-O', 'volunteers-O', '.-O']
['During-O', 'the-O', 'first-O', 'test-O', '0-O', '.-O']
['9-O', '%-O', 'NaCl-B-Chemical', 'was-O', 'given-O', 'i-O', '.-O']
['v-O', '.;-O', 'during-O', 'the-O', 'second-O', 'test-O', '200-O', 'micrograms-O', 'of-O', 'hCRH-B-Chemical', '(-O', 'n-O', '=', '12-O', ')-O', 'or-O', '400-O', 'micrograms-O', 'of-O', 'TRH-B-Chemical', '(-O', 'n-O', '=', '6-O', ')-O', 'was-O', 'administered-O', 'i-O', '.-O']
['v-O', '.-O']
['Nine-O', 'subjects-O', 'received-O', '0-O', '.-O']
['9-O', '%-O', 'NaCl-B-Chemical', 'i-O', '.-O']
['v-O', '.-O']
['during-O', 'both-O', 'rebreathing-O', 'manoeuvres-O', '.-O']
['The-O', 'CO2-B-Chemical', ',-O', 'response-O', 'curves-O', 'for-O', 'the-O', 'two-O', 'tests-O', 'were-O', 'compared-O', 'within-O', 'the-O', 'same-O', 'subject-O', '.-O']
['In-O', 'the-O', 'hCRH-B-Chemical', 'group-O', 'a-O', 'marked-O', 'parallel-O', 'shift-O', 'of-O', 'the-O', 'CO2-B-Chemical', ',-O', 'response-O', 'curve-O', 'to-O', 'the-O', 'left-O', 'was-O', 'observed-O', 'after-O', 'hCRH-B-Chemical', '(-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'The-O', 'same-O', 'effect-O', 'occurred-O', 'following-O', 'TRH-B-Chemical', 'but-O', 'was-O', 'less-O', 'striking-O', '(-O', 'P-O', '=', '0-O', '.-O']
['05-O', ').-O', 'hCRH-B-Chemical', 'and-O', 'TRH-B-Chemical', 'caused-O', 'a-O', 'reduction-O', 'in-O', 'the-O', 'CO2-B-Chemical', 'threshold-O', '.-O']
['The-O', 'CO2-B-Chemical', ',-O', 'response-O', 'curves-O', 'in-O', 'the-O', 'control-O', 'group-O', 'were-O', 'nearly-O', 'identical-O', '.-O']
['The-O', 'results-O', 'indicate-O', 'an-O', 'additive-O', 'effect-O', 'of-O', 'both-O', 'releasing-O', 'hormones-O', 'on-O', 'the-O', 'hypercapnic-B-Disease']
['Lamivudine-B-Chemical', 'is-O', 'effective-O', 'in-O', 'suppressing-O', 'hepatitis-B-Disease', 'B-I-Disease', 'virus-O', 'DNA-O', 'in-O', 'Chinese-O', 'hepatitis-B-Disease', 'B-I-Disease', 'surface-O', 'antigen-O', 'carriers-O', ':-O', 'a-O', 'placebo-O', ',-O', 'controlled-O', 'trial-O', '.-O']
['Lamivudine-B-Chemical', 'is-O', 'a-O', 'novel-O', '2-O', 'dideoxy-O', 'cytosine-B-Chemical', 'analogue-O', 'that-O', 'has-O', 'potent-O', 'inhibitory-O', 'effects-O', 'on-O', 'hepatitis-B-Chemical', 'B-I-Chemical', 'virus-I-Chemical', 'replication-O', 'in-O', 'vitro-O', 'and-O', 'in-O', 'vivo-O', '.-O']
['We-O', 'performed-O', 'a-O', 'single-O', ',-O', 'blind-O', ',-O', 'placebo-O', ',-O', 'controlled-O', 'study-O', 'to-O', 'assess-O', 'its-O', 'effectiveness-O', 'and-O', 'safety-O', 'in-O', 'Chinese-O', 'hepatitis-B-Chemical', 'B-I-Chemical', 'surface-O', 'antigen-I-Chemical', '(-O', 'HBsAg-B-Chemical', ')-O', 'carriers-O', '.-O']
['Forty-O', ',-O', 'two-O', 'Chinese-O', 'HBsAg-O', 'carriers-O', 'were-O', 'randomized-O', 'to-O', 'receive-O', 'placebo-O', '(-O', '6-O', 'patients-O', ')-O', 'or-O', 'lamivudine-B-Chemical', 'orally-O', 'in-O', 'dosages-O', 'of-O', '25-O', 'mg-O', ',-O', '100-O', 'mg-O', ',-O', 'or-O', '300-O', 'mg-O', 'daily-O', '(-O', '12-O', 'patients-O', 'for-O', 'each-O', 'dosage-O', ')-O', '.-O', 'The-O', 'drug-O', 'was-O', 'given-O', 'for-O', '4-O', 'weeks-O', '.-O']
['The-O', 'patients-O', 'were-O', 'closely-O', 'monitored-O', 'clinically-O', ',-O', 'biochemically-O', ',-O', 'and-O', 'serologically-O', 'up-O', 'to-O', '4-O', 'weeks-O', 'after-O', 'drug-O', 'treatment-O', '.-O']
['All-O', '36-O', 'patients-O', 'receiving-O', 'lamivudine-B-Chemical', 'had-O', 'a-O', 'decrease-O', 'in-O', 'hepatitis-B-Disease', 'B-I-Disease', 'virus-O', '(-O', 'HBV-O', ')-O', 'DNA-O', 'values-O', 'of-O', '>90-O', '(-O', 'P-O', '<.-O', '001-O', 'compared-O', 'with-O', 'placebo-O', ').-O', 'Although-O', '25-O', 'mg-O', 'of-O', 'lamivudine-B-Chemical', 'was-O', 'slightly-O', 'less-O', 'effective-O', 'than-O', '100-O', 'mg-O', '(-O', 'P-O', '=.-O', '011-O', ')-O', 'and-O', '300-O', 'mg-O', '(-O', 'P-O', '=.-O', '005-O', ')-O', 'it-O', 'still-O', 'induced-O', '94-O', '%-O', 'suppression-O', 'of-O', 'HBV-O', 'DNA-O', 'after-O', 'the-O', 'fourth-O', 'week-O', 'of-O', 'therapy-O', '.-O']
['HBV-O', 'DNA-O', 'values-O', 'returned-O', 'to-O', 'pretreatment-O', 'levels-O', 'within-O', '4-O', 'weeks-O', 'of-O', 'cessation-O', 'of-O', 'therapy-O', '.-O']
['There-O', 'was-O', 'no-O', 'change-O', 'in-O', 'the-O', 'hepatitis-B-Chemical', 'B-I-Chemical', 'e-I-Chemical', 'antigen-I-Chemical', 'status-O', 'or-O', 'in-O', 'aminotransferase-O', 'levels-O', '.-O']
['No-O', 'serious-O', 'adverse-O', 'events-O', 'were-O', 'observed-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'a-O', '4-O', ',-O', 'week-O', 'course-O', 'of-O', 'lamivudine-B-Chemical', 'was-O', 'safe-O', 'and-O', 'effective-O', 'in-O', 'suppression-O', 'of-O', 'HBV-O', 'DNA-O', 'in-O', 'Chinese-O', 'HBsAg-B-Chemical', 'carriers-O', '.-O']
['The-O', 'suppression-O', 'was-O', '>-O', '90-O', '%-O', 'but-O', 'reversible-O', '.-O']
['Studies-O', 'with-O', 'long-O', ',-O', 'term-O', 'lamivudine-B-Chemical']
['Population-O', ',-O', 'based-O', 'study-O', 'of-O', 'risk-O', 'of-O', 'venous-B-Disease', 'thromboembolism-I-Disease', 'associated-O', 'with-O', 'various-O', 'oral-B-Chemical', 'contraceptives-I-Chemical', '.-O']
['BACKGROUND-O', ':-O', 'Four-O', 'studies-O', 'published-O', 'since-O', 'December-O', ',-O', '1995-O', ',-O', 'reported-O', 'that-O', 'the-O', 'incidence-O', 'of-O', 'venous-B-Disease', 'thromboembolism-I-Disease', '(-O', 'VTE-B-Disease', ')-O', 'was-O', 'higher-O', 'in-O', 'women-O', 'who-O', 'used-O', 'oral-B-Chemical', 'contraceptives-I-Chemical', '(-O', 'OCs-O', ')-O', 'containing-O', 'the-O', 'third-O', ',-O', 'generation-O', 'progestagens-O', 'gestodene-B-Chemical', 'or-O', 'desogestrel-B-Chemical', 'than-O', 'in-O', 'users-O', 'of-O', 'OCs-O', 'containing-O', 'second-O', ',-O', 'generation-O', 'progestagens-O', '.-O']
['However-O', ',-O', 'confounding-O', 'and-O', 'bias-O', 'in-O', 'the-O', 'design-O', 'of-O', 'these-O', 'studies-O', 'may-O', 'have-O', 'affected-O', 'the-O', 'findings-O', '.-O']
['The-O', 'aim-O', 'of-O', 'our-O', 'study-O', 'was-O', 'to-O', 're-O', ',-O', 'examine-O', 'the-O', 'association-O', 'between-O', 'risk-O', 'of-O', 'VTE-B-Disease', 'and-O', 'OC-B-Chemical', 'use-O', 'with-O', 'a-O', 'different-O', 'study-O', 'design-O', 'and-O', 'analysis-O', 'to-O', 'avoid-O', 'some-O', 'of-O', 'the-O', 'bias-O', 'and-O', 'confounding-O', 'of-O', 'the-O', 'earlier-O', 'studies-O', '.-O']
['METHODS-O', ':-O', 'We-O', 'used-O', 'computer-O', 'records-O', 'of-O', 'patients-O', 'from-O', '143-O', 'general-O', 'practices-O', 'in-O', 'the-O', 'UK-O', '.-O']
['The-O', 'study-O', 'was-O', 'based-O', 'on-O', 'the-O', 'medical-O', 'records-O', 'of-O', 'about-O', '540-O', ',', '000-O', 'women-O', 'born-O', 'between-O', '1941-O', 'and-O', '1981-O', '.-O']
['All-O', 'women-O', 'who-O', 'had-O', 'a-O', 'recorded-O', 'diagnosis-O', 'of-O', 'deep-vein-B-Disease', 'thrombosis-I-Disease', ',-O', 'venous-B-Disease', 'thrombosis-I-Disease', 'not-O', 'otherwise-O', 'specified-O', ',-O', 'or-O', 'pulmonary-B-Disease', 'embolus-I-Disease', 'during-O', 'the-O', 'study-O', 'period-O', ',-O', 'and-O', 'who-O', 'had-O', 'been-O', 'treated-O', 'with-O', 'an-O', 'anticoagulant-B-Chemical', 'were-O', 'identified-O', 'as-O', 'potential-O', 'cases-O', 'of-O', 'VTE-B-Disease', '.-O']
['We-O', 'did-O', 'a-O', 'cohort-O', 'analysis-O', 'to-O', 'estimate-O', 'and-O', 'compare-O', 'incidence-O', 'of-O', 'VTE-B-Disease', 'in-O', 'users-O', 'of-O', 'the-O', 'main-O', 'OC-B-Chemical', 'preparations-O', ',-O', 'and-O', 'a-O', 'nested-O', 'case-O', ',-O', 'control-O', 'study-O', 'to-O', 'calculate-O', 'the-O', 'odds-O', 'ratios-O', 'of-O', 'VTE-B-Disease', 'associated-O', 'with-O', 'use-O', 'of-O', 'different-O', 'types-O', 'of-O', 'OC-B-Chemical', ',-O', 'after-O', 'adjustment-O', 'for-O', 'potential-O', 'confounding-O', 'factors-O', '.-O']
['In-O', 'the-O', 'case-O', ',-O', 'control-O', 'study-O', ',-O', 'we-O', 'matched-O', 'cases-O', 'to-O', 'controls-O', 'by-O', 'exact-O', 'year-O', 'of-O', 'birth-O', ',-O', 'practice-O', ',-O', 'and-O', 'current-O', 'use-O', 'of-O', 'OCs-B-Chemical', '.-O']
['We-O', 'used-O', 'a-O', 'multiple-O', 'logistic-O', 'regression-O', 'model-O', 'that-O', 'included-O', 'body-O', 'mass-O', 'index-O', ',-O', 'number-O', 'of-O', 'cycles-O', ',-O', 'change-O', 'in-O', 'type-O', 'of-O', 'OC-B-Chemical', 'prescribed-O', 'within-O', '3-O', 'months-O', 'of-O', 'the-O', 'event-O', ',-O', 'previous-O', 'pregnancy-O', ',-O', 'and-O', 'concurrent-O', 'disease-B-Disease', '.-O']
['FINDINGS-O', ':-O', '85-O', 'women-O', 'met-O', 'the-O', 'inclusion-O', 'criteria-O', 'for-O', 'VTE-B-Disease', ',-O', 'two-O', 'of-O', 'whom-O', 'were-O', 'users-O', 'of-O', 'progestagen-B-Chemical', ',-O', 'only-O', 'OCs-B-Chemical', '.-O']
['Of-O', 'the-O', '83-O', 'cases-O', 'of-O', 'VTE-B-Disease', 'associated-O', 'with-O', 'use-O', 'of-O', 'combined-O', 'OCs-O', ',-O', '43-O', 'were-O', 'recorded-O', 'as-O', 'deep-vein-B-Disease', 'thrombosis-B-Disease', ',-O', '35-O', 'as-O', 'pulmonary-B-Disease', 'thrombosis-B-Disease', ',-O', 'and-O', 'five-O', 'as-O', 'venous-B-Disease', 'thrombosis-B-Disease', 'not-O', 'otherwise-O', 'specified-O', '.-O']
['The-O', 'crude-O', 'rate-O', 'of-O', 'VTE-B-Disease', 'per-O', '10-O', ',-O', '000-O', 'woman-O', ',-O', 'years-O', 'was-O', '4-O', '.-O']
['10-O', 'in-O', 'current-O', 'users-O', 'of-O', 'any-O', 'OC-B-Chemical', ',-O', '3-O', '.-O']
['10-O', 'in-O', 'users-O', 'of-O', 'second-O', ',-O', 'generation-O', 'OCs-I-Chemical', ',-O', 'and-O', '4-O', '.-O']
['96-O', 'in-O', 'users-O', 'of-O', 'third-O', ',-O', 'generation-O', 'preparations-O', '.-O']
['After-O', 'adjustment-O', 'for-O', 'age-O', ',-O', 'the-O', 'rate-O', 'ratio-O', 'of-O', 'VTE-B-Disease', 'in-O', 'users-O', 'of-O', 'third-O', ',-O', 'generation-O', 'relative-O', 'to-O', 'second-O', ',-O', 'generation-O', 'OCs-B-Chemical', 'was-O', '1-O', '.-O']
['68-O', '(-O', '95-O', '%-O', 'CI-O', '1-O', '.-O']
['04-O', ',-O', '2-O', '.-O']
['75-O', ')-O', 'Logistic-O', 'regression-O', 'showed-O', 'no-O', 'significant-O', 'difference-O', 'in-O', 'the-O', 'risk-O', 'of-O', 'VTE-B-Disease', 'between-O', 'users-O', 'of-O', 'third-O', ',-O', 'generation-O', 'and-O', 'second-O', ',-O', 'generation-O', 'OCs-B-Chemical', '.-O']
['Among-O', 'users-O', 'of-O', 'third-O', ',-O', 'generation-O', 'progestagens-O', ',-O', 'the-O', 'risk-O', 'of-O', 'VTE-B-Disease', 'was-O', 'higher-O', 'in-O', 'users-O', 'of-O', 'desogestrel-B-Chemical', 'with-O', '20-O', 'g-O', 'ethinyloestradiol-B-Chemical', 'than-O', 'in-O', 'users-O', 'of-O', 'gestodene-B-Chemical', 'or-O', 'desogestrel-B-Chemical', 'with-O', '30-O', 'g-O', 'ethinyloestradiol-B-Chemical', '.-O']
['With-O', 'all-O', 'second-O', ',-O', 'generation-O', 'OCs-B-Chemical', 'as-O', 'the-O', 'reference-O', ',-O', 'the-O', 'odds-O', 'ratios-O', 'for-O', 'VTE-B-Disease', 'were-O', '3-O', '.-O']
['49-O', '(-O', '1-O', '.-O']
['21-O', ',-O', '10-O', '.-O']
['12-O', ')-O', 'for-O', 'desogestrel-B-Chemical', 'plus-O', '20-O', 'g-O', 'ethinyloestradiol-B-Chemical', 'and-O', '1-O', '.-O']
['18-O', '(-O', '0-O', '.-O']
['66-O', ',-O', '2-O', '.-O']
['17-O', ')-O', 'for-O', 'the-O', 'other-O', 'third-O', ',-O', 'generation-O', 'progestagens-B-Chemical', '.-O']
['INTERPRETATION-O', ':-O', 'The-O', 'previously-O', 'reported-O', 'increase-O', 'in-O', 'odds-O', 'ratio-O', 'associated-O', 'with-O', 'third-O', ',-O', 'generation-O', 'OCs-B-Chemical', 'when-O', 'compared-O', 'with-O', 'second-O', ',-O', 'generation-O', 'products-O', 'is-O', 'likely-O', 'to-O', 'have-O', 'been-O', 'the-O', 'result-O', 'of-O', 'residual-O', 'confounding-O', 'by-O', 'age-O', '.-O']
['The-O', 'increased-O', 'odds-O', 'ratio-O', 'associated-O', 'with-O', 'products-O', 'containing-O', '20-O', 'micrograms-O', 'ethinyloestradiol-B-Chemical', 'and-O', 'desogestrel-B-Chemical']
['MK-801-B-Chemical', 'augments-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'electrographic-O', 'seizure-B-Disease', 'but-O', 'protects-O', 'against-O', 'brain-O', 'damage-I-Disease', 'in-O', 'rats-O', '.-O']
['1-O', '.-O']
['The-O', 'authors-O', 'examined-O', 'the-O', 'anticonvulsant-O', 'effects-O', 'of-O', 'MK-801-B-Chemical', 'on-O', 'the-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'seizure-B-Disease', 'model-O', '.-O']
['Intraperitoneal-O', 'injection-O', 'of-O', 'pilocarpine-B-Chemical', '(-O', '400-O', 'mg-O', '/-O', 'kg-O', ')-O', 'induced-O', 'tonic-O', 'and-O', 'clonic-B-Disease', 'seizure-B-Disease', '.-O']
['Scopolamine-B-Chemical', '(-O', '10-O', 'mg-O', '/-O', 'kg-O', ')-O', 'and-O', 'pentobarbital-B-Chemical', '(-O', '5-O', 'mg-O', '/-O', 'kg-O', ')-O', 'prevented-O', 'development-O', 'of-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'behavioral-O', 'seizure-B-Disease', 'but-O', 'MK-801-B-Chemical', '(-O', '0-O', '.-O']
['5-O', 'mg-O', '/-O', 'kg-O', ')-O', 'did-O', 'not-O', '.-O']
['2-O', '.-O']
['An-O', 'electrical-O', 'seizure-B-Disease', 'measured-O', 'with-O', 'hippocampal-O', 'EEG-O', 'appeared-O', 'in-O', 'the-O', 'pilocarpine-B-Chemical', ',-O', 'treated-O', 'group-O', '.-O']
['Scopolamine-B-Chemical', 'and-O', 'pentobarbital-B-Chemical', 'blocked-O', 'the-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'electrographic-O', 'seizure-B-Disease', ',-O', 'MK-801-B-Chemical', 'treatment-O', 'augmented-O', 'the-O', 'electrographic-O', 'seizure-B-Disease', 'induced-O', 'by-O', 'pilocarpine-B-Chemical', '.-O']
['3-O', '.-O']
['Brain-O', 'damage-I-Disease', 'was-O', 'assessed-O', 'by-O', 'examining-O', 'the-O', 'hippocampus-O', 'microscopically-O', '.-O']
['Pilocarpine-B-Chemical', 'produced-O', 'neuronal-O', 'death-B-Disease', 'in-O', 'the-O', 'hippocampus-O', ',-O', 'which-O', 'showed-O', 'pyknotic-O', 'changes-O', '.-O']
['Pentobarbital-B-Chemical', ',-O', 'scopolamine-B-Chemical', 'and-O', 'MK-801-B-Chemical', 'protected-O', 'the-O', 'brain-O', 'damage-O', 'by-O', 'pilocarpine-B-Chemical', ',-O', 'though-O', 'in-O', 'the-O', 'MK-801-B-Chemical', ',-O', 'treated-O', 'group-O', ',-O', 'the-O', 'pyramidal-O', 'cells-O', 'of-O', 'hippocampus-O', 'appeared-O', 'darker-O', 'than-O', 'normal-O', '.-O']
['In-O', 'all-O', 'treatments-O', ',-O', 'granule-O', 'cells-O', 'of-O', 'the-O', 'dentate-O', 'gyrus-O', 'were-O', 'not-O', 'affected-O', '.-O']
['4-O', '.-O']
['These-O', 'results-O', 'indicate-O', 'that-O', 'status-B-Disease', 'epilepticus-I-Disease', 'induced-O', 'by-O', 'pilocarpine-B-Chemical', 'is-O', 'initiated-O', 'by-O', 'cholinergic-O', 'overstimulation-O', 'and-O', 'propagated-O', 'by-O', 'glutamatergic-O', 'transmission-O', ',-O', 'the-O', 'elevation-O', 'of-O', 'which-O', 'may-O', 'cause-O', 'brain-O', 'damage-O', 'through-O', 'an-O', 'excitatory-O', 'NMDA-B-Chemical']
['Paclitaxel-B-Chemical', ',-O', '5-fluorouracil-B-Chemical', ',-O', 'and-O', 'folinic-B-Chemical', 'acid-I-Chemical', 'in-O', 'metastatic-O', 'breast-B-Disease', 'cancer-I-Disease', ':-O', 'BRE-O', ',-O', '26-O', ',-O', 'a-O', 'phase-O', 'II-O', 'trial-O', '.-O']
['5-Fluorouracil-B-Chemical', 'plus-O', 'folinic-B-Chemical', 'acid-I-Chemical', 'and-O', 'paclitaxel-B-Chemical', '(-O', 'Taxol-B-Chemical', ';-O', 'Bristol-O', ',', 'Myers-O', 'Squibb-O', 'Company-O', ',', 'Princeton-O', ',', 'NJ-O', ')-O', 'are-O', 'effective-O', 'salvage-O', 'therapies-O', 'for-O', 'metastatic-O', 'breast-B-Disease', 'cancer-I-Disease', 'patients-O', '.-O']
['Paclitaxel-B-Chemical', 'and-O', '5-fluorouracil-B-Chemical', 'have-O', 'additive-O', 'cytotoxicity-O', 'in-O', 'MCF-O', ',-O', '7-O', 'cell-O', 'lines-O', '.-O']
['We-O', 'performed-O', 'a-O', 'phase-O', 'II-O', 'trial-O', 'of-O', 'paclitaxel-B-Chemical', '175-O', 'mg-O', '/-O', 'm2-O', 'over-O', '3-O', 'hours-O', 'on-O', 'day-O', 'I-O', 'followed-O', 'by-O', 'folinic-B-Chemical', 'acid-I-Chemical', '300-O', 'mg-O', 'over-O', '1-O', 'hour-O', 'before-O', '5-fluorouracil-B-Chemical', '350-O', 'mg-O', '/-O', 'm2-O', 'on-O', 'days-O', '1-O', 'to-O', '3-O', 'every-O', '28-O', 'days-O', '(-O', 'TFL-O', ')-O', 'in-O', 'women-O', 'with-O', 'metastatic-O', 'breast-B-Disease', 'cancer-I-Disease', '.-O']
['Analysis-O', 'is-O', 'reported-O', 'on-O', '37-O', 'patients-O', 'with-O', 'a-O', 'minimum-O', 'of-O', '6-O', 'months-O', 'follow-O', ',-O', 'up-O', 'who-O', 'received-O', 'a-O', 'total-O', 'of-O', '192-O', 'cycles-O', 'of-O', 'TFL-O', ':-O', 'nine-O', 'cycles-O', '(-O', '5-O', ')-O', 'were-O', 'associated-O', 'with-O', 'grade-O', '3-O', '/-O', '4-O', 'neutropenia-B-Disease', 'requiring-O', 'hospitalization-O', ';-O', 'seven-O', '(-O', '4-O', ')-O', 'cycles-O', 'in-O', 'two-O', 'patients-O', 'required-O', 'granulocyte-O', 'colony-stimulating-O', 'factor-O', 'due-O', 'to-O', 'neutropenia-B-Disease', ';-O', 'no-O', 'patient-O', 'required-O', 'platelet-O', 'transfusions-O', '.-O']
['Grade-O', '3-O', '/-O', '4-O', 'nonhematologic-B-Disease', 'toxicities-B-Disease', 'were-O', 'uncommon-O', '.-O']
['Among-O', 'the-O', '34-O', 'patients-O', 'evaluable-O', 'for-O', 'response-O', ',-O', 'there-O', 'were-O', 'three-O', 'complete-O', 'responses-O', '(-O', '9-O', ')-O', 'and-O', '18-O', 'partial-O', 'responses-O', '(-O', '53-O', ')-O', 'for-O', 'an-O', 'overall-O', 'response-O', 'rate-O', 'of-O', '62-O', '.-O', 'Of-O', 'the-O', '19-O', 'evaluable-O', 'patients-O', 'with-O', 'prior-O', 'doxorubicin-B-Chemical', 'exposure-O', ',-O', '11-O', '(-O', '58-O', ')-O', 'responded-O', 'compared-O', 'with-O', 'nine-O', 'of-O', '15-O', '(-O', '60-O', ')-O', 'without-O', 'prior-O', 'doxorubicin-B-Chemical', '.-O']
['Plasma-O', 'paclitaxel-B-Chemical', 'concentrations-O', 'were-O', 'measured-O', 'at-O', 'the-O', 'completion-O', 'of-O', 'paclitaxel-B-Chemical', 'infusion-O', 'and-O', 'at-O', '24-O', 'hours-O', 'in-O', '19-O', 'patients-O', '.-O']
['TFL-B-Chemical', 'is-O', 'an-O', 'active-O', ',-O', 'well-O', ',-O', 'tolerated-O', 'regimen-O', 'in-O', 'metastatic-O', 'breast-B-Disease', 'cancer-I-Disease']
['Efficacy-O', 'and-O', 'proarrhythmia-O', 'with-O', 'the-O', 'use-O', 'of-O', 'd,l-sotalol-B-Chemical', 'for-O', 'sustained-O', 'ventricular-B-Disease', 'tachyarrhythmias-I-Disease', '.-O']
['This-O', 'study-O', 'prospectively-O', 'evaluated-O', 'the-O', 'clinical-O', 'efficacy-O', ',-O', 'the-O', 'incidence-O', 'of-O', 'torsades-B-Disease', 'de-I-Disease', 'pointes-I-Disease', ',-O', 'and-O', 'the-O', 'presumable-O', 'risk-O', 'factors-O', 'for-O', 'torsades-B-Disease', 'de-I-Disease', 'pointes-I-Disease', 'in-O', 'patients-O', 'treated-O', 'with-O', 'd,l-sotalol-B-Chemical', 'for-O', 'sustained-O', 'ventricular-B-Disease', 'tachyarrhythmias-I-Disease', '.-O']
['Eighty-O', ',-O', 'one-O', 'consecutive-O', 'patients-O', '(-O', '54-O', 'with-O', 'coronary-O', 'artery-O', 'disease-O', ',-O', 'and-O', '20-O', 'with-O', 'dilated-O', 'cardiomyopathy-O', ')-O', 'with-O', 'inducible-O', 'sustained-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'or-O', 'ventricular-B-Disease', 'fibrillation-I-Disease', 'received-O', 'oral-O', 'd,l-sotalol-B-Chemical', 'to-O', 'prevent-O', 'induction-O', 'of-O', 'the-O', 'ventricular-O', 'tachyarrhythmia-O', '.-O']
['During-O', 'oral-O', 'loading-O', 'with-O', 'd,l-sotalol-B-Chemical', ',-O', 'continuous-O', 'electrocardiographic-O', '(-O', 'ECG-O', ')-O', 'monitoring-O', 'was-O', 'performed-O', '.-O']
['Those-O', 'patients-O', 'in-O', 'whom-O', 'd,l-sotalol-B-Chemical', 'prevented-O', 'induction-O', 'of-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'or-O', 'ventricular-B-Disease', 'fibrillation-I-Disease', 'were-O', 'discharged-O', 'with-O', 'the-O', 'drug-O', 'and-O', 'followed-O', 'up-O', 'on-O', 'an-O', 'outpatient-O', 'basis-O', 'for-O', '21-O', '+-O', '18-O', 'months-O', '.-O']
['Induction-O', 'of-O', 'the-O', 'ventricular-B-Disease', 'tachyarrhythmia-I-Disease', 'was-O', 'prevented-O', 'by-O', 'oral-O', 'd,l-sotalol-B-Chemical', 'in-O', '35-O', '(-O', '43-O', ')-O', 'patients-O', ';-O', 'the-O', 'ventricular-B-Disease', 'tachyarrhythmia-I-Disease', 'remained-O', 'inducible-O', 'in-O', '40-O', '(-O', '49-O', ')-O', 'patients-O', ';-O', 'and-O', 'two-O', '(-O', '2-O', '.-O']
['5-O', ')-O', 'patients-O', 'did-O', 'not-O', 'tolerate-O', 'even-O', '40-O', 'mg-O', 'of-O', 'd,l-sotalol-B-Chemical', 'once-O', 'daily-O', '.-O']
['Four-O', '(-O', '5-O', ')-O', 'patients-O', 'had-O', 'from-O', 'torsades-B-Disease', 'de-O', 'pointes-I-Disease', 'during-O', 'the-O', 'initial-O', 'oral-O', 'treatment-O', 'with-O', 'd,l-sotalol-B-Chemical', '.-O']
['Neither-O', 'ECG-O', '[', 'sinus-O', ',', 'cycle-O', 'length-O', '(', 'SCL-O', '),', 'QT-O', 'or-O', 'QTc-O', 'interval-O', ',', 'or-O', 'U-O', 'wave-O', ']', 'nor-O', 'clinical-O', 'parameters-O', 'identified-O', 'patients-O', 'at-O', 'risk-O', 'for-O', 'torsades-B-Disease', 'de-I-Disease', 'pointes-I-Disease', '.-O']
['However-O', ',-O', 'the-O', 'oral-O', 'dose-O', 'of-O', 'd,l-sotalol-B-Chemical', 'was-O', 'significantly-O', 'lower-O', 'in-O', 'patients-O', 'with-O', 'torsades-B-Disease', 'de-I-Disease', 'pointes-I-Disease', '(-O', '200-O', '+-O', '46-O', 'vs-O', '.-O']
['328-O', '+-O', '53-O', 'mg-O', '/-O', 'day-O', ';-O', 'p-O', '=-O', '0-O', '.-O']
['0017-O', ').-O', 'Risk-O', 'factors-O', 'associated-O', 'with-O', 'the-O', 'development-O', 'of-O', 'torsades-B-Disease', 'de-O', 'pointes-I-Disease', 'were-O', 'the-O', 'appearance-O', 'of-O', 'an-O', 'U-O', 'wave-O', '(-O', 'p-O', '=O', '0-O', '.-O']
['049-O', '),-O', 'female-O', 'gender-O', '(-O', 'p-O', '=', '0-O', '.-O']
['015-O', ')-O', 'and-O', 'significant-O', 'dose-O', ',-O', 'corrected-O', 'changes-O', 'of-O', 'SCL-O', ',-O', 'QT-O', 'interval-O', ',-O', 'and-O', 'QTc-O', 'interval-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'During-O', 'follow-O', ',-O', 'up-O', ',-O', 'seven-O', '(-O', '20-O', ')-O', 'patients-O', 'had-O', 'a-O', 'nonfatal-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'recurrence-O', ',-O', 'and-O', 'two-O', '(-O', '6-O', ')-O', 'patients-O', 'died-O', 'suddenly-O', '.-O']
['One-O', 'female-O', 'patient-O', 'with-O', 'stable-O', 'cardiac-B-Disease', 'disease-I-Disease', 'had-O', 'recurrent-O', 'torsades-B-Disease', 'de-O', 'pointes-I-Disease', 'after-O', '2-O', 'years-O', 'of-O', 'successful-O', 'treatment-O', 'with-O', 'd,l-sotalol-B-Chemical', '.-O']
['Torsades-B-Disease', 'de-I-Disease', 'pointes-I-Disease', 'occurred-O', 'early-O', 'during-O', 'treatment-O', 'even-O', 'with-O', 'low-O', 'doses-O', 'of-O', 'oral-O', 'd,l-sotalol-B-Chemical', '.-O']
['Pronounced-O', 'changes-O', 'in-O', 'the-O', 'surface-O', 'ECG-O', '(-O', 'cycle-O', 'length-O', ',-O', 'QT-O', ',-O', 'and-O', 'QTc-O', ')-O', 'in-O', 'relation-O', 'to-O', 'the-O', 'dose-O', 'of-O', 'oral-O', 'd,l-sotalol-B-Chemical', 'might-O', 'identify-O', 'a-O', 'subgroup-O', 'of-O', 'patients-O', 'with-O', 'an-O', 'increased-O', 'risk-O', 'for-O', 'torsades-B-Disease', 'de-O', 'pointes-I-Disease', '.-O']
['Other-O', 'ECG-O', 'parameters-O', 'before-O', 'the-O', 'application-O', 'of-O', 'd,l-sotalol-B-Chemical', 'did-O', 'not-O', 'identify-O', 'patients-O', 'at-O', 'increased-O', 'risk-O', 'for-O', 'torsades-B-Disease', 'de-I-Disease', 'pointes-I-Disease', '.-O']
['Recurrence-O', 'rates-O', 'of-O', 'ventricular-B-Disease', 'tachyarrhythmias-I-Disease', 'are-O', 'high-O', 'despite-O', 'complete-O', 'suppression-O', 'of-O', 'the-O', 'arrhythmia-B-Disease', 'during-O', 'programmed-O', 'stimulation-O', '.-O']
['Therefore-O', 'programmed-O', 'electrical-O', 'stimulation-O', 'in-O', 'the-O', 'case-O', 'of-O', 'd,l-sotalol-B-Chemical']
['Chronic-O', 'hyperprolactinemia-B-Disease', 'and-O', 'changes-O', 'in-O', 'dopamine-B-Chemical', 'neurons-O', '.-O']
['The-O', 'tuberoinfundibular-O', 'dopaminergic-O', '(-O', 'TIDA-O', ')-O', 'system-O', 'is-O', 'known-O', 'to-O', 'inhibit-O', 'prolactin-O', '(-O', 'PRL-O', ')-O', 'secretion-O', '.-O']
['In-O', 'young-O', 'animals-O', 'this-O', 'system-O', 'responds-O', 'to-O', 'acute-O', 'elevations-O', 'in-O', 'serum-O', 'PRL-B-Chemical', 'by-O', 'increasing-O', 'its-O', 'activity-O', '.-O']
['However-O', ',-O', 'this-O', 'responsiveness-O', 'is-O', 'lost-O', 'in-O', 'aging-O', 'rats-O', 'with-O', 'chronically-O', 'high-O', 'serum-O', 'PRL-B-Chemical', 'levels-O', '.-O']
['The-O', 'purpose-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'induce-O', 'hyperprolactinemia-B-Disease', 'in-O', 'rats-O', 'for-O', 'extended-O', 'periods-O', 'of-O', 'time-O', 'and-O', 'examine-O', 'its-O', 'effects-O', 'on-O', 'dopaminergic-O', 'systems-O', 'in-O', 'the-O', 'brain-O', '.-O']
['Hyperprolactinemia-B-Disease', 'was-O', 'induced-O', 'by-O', 'treatment-O', 'with-O', 'haloperidol-B-Chemical', ',-O', 'a-O', 'dopamine-B-Chemical', 'receptor-O', 'antagonist-O', ',-O', 'and-O', 'Palkovits-O', 'x-O', 'microdissection-O', 'technique-O', 'in-O', 'combination-O', 'with-O', 'high-O', ',-O', 'performance-O', 'liquid-O', 'chromatography-O', 'was-O', 'used-O', 'to-O', 'measure-O', 'neurotransmitter-O', 'concentrations-O', 'in-O', 'several-O', 'areas-O', 'of-O', 'the-O', 'brain-O', '.-O']
['After-O', '6-O', 'months-O', 'of-O', 'hyperprolactinemia-B-Disease', ',-O', 'dopamine-B-Chemical', '(-O', 'DA-B-Chemical', ')-O', 'concentrations-O', 'in-O', 'the-O', 'median-O', 'eminence-O', '(-O', 'ME-O', ')-O', 'increased-O', 'by-O', '84-O', '%-O', 'over-O', 'the-O', 'control-O', 'group-O', '.-O']
['Nine-O', 'months-O', 'of-O', 'hyperprolactinemia-B-Disease', 'produced-O', 'a-O', '50-O', '%-O', 'increase-O', 'in-O', 'DA-B-Chemical', 'concentrations-O', 'in-O', 'the-O', 'ME-O', 'over-O', 'the-O', 'control-O', 'group-O', '.-O']
['However-O', ',-O', 'DA-O', 'response-O', 'was-O', 'lost-O', 'if-O', 'a-O', '9-O', ',', 'month-O', 'long-O', 'haloperidol-B-Chemical', ',-O', 'induced-O', 'hyperprolactinemia-B-Disease', 'was-O', 'followed-O', 'by-O', 'a-O', '1-O', '1-O', '/', '2-O', 'month-O', ',-O', 'long-O', 'extremely-O', 'high-O', 'increase-O', 'in-O', 'serum-O', 'PRL-O', 'levels-O', 'produced-O', 'by-O', 'implantation-O', 'of-O', 'MMQ-O', 'cells-O', 'under-O', 'the-O', 'kidney-O', 'capsule-O', '.-O']
['There-O', 'was-O', 'no-O', 'change-O', 'in-O', 'the-O', 'levels-O', 'of-O', 'DA-B-Chemical', ',-O', 'norepinephrine-B-Chemical', '(-O', 'NE-B-Chemical', ')-O', 'serotonin-B-Chemical', '(-O', '5-HT-B-Chemical', ')-O', 'or-O', 'their-O', 'metabolites-O', 'in-O', 'the-O', 'arcuate-O', 'nucleus-O', '(-O', 'AN-O', ')-O', 'medial-O', 'preoptic-O', 'area-O', '(-O', 'MPA-O', ')-O', 'caudate-O', 'putamen-O', '(-O', 'CP-O', ')-O', 'substantia-O', 'nigra-O', '(-O', 'SN-O', ')-O', 'and-O', 'zona-O', 'incerta-O', '(-O', 'ZI-O', ')-O', 'except-O', 'for-O', 'a-O', 'decrease-O', 'in-O', '5-hydroxyindoleacetic-B-Chemical', 'acid-O', '(-O', '5-HIAA-B-Chemical', ')-O', 'in-O', 'the-O', 'AN-O', 'after-O', '6-O', ',-O', 'months-O', 'of-O', 'hyperprolactinemia-B-Disease', 'and-O', 'an-O', 'increase-O', 'in-O', 'DA-B-Chemical', 'concentrations-O', 'in-O', 'the-O', 'AN-O', 'after-O', '9-O', ',-O', 'months-O', 'of-O', 'hyperprolactinemia-B-Disease', '.-O']
['These-O', 'results-O', 'demonstrate-O', 'that-O', 'hyperprolactinemia-B-Disease', 'specifically-O', 'affects-O', 'TIDA-O', 'neurons-O', 'and-O', 'these-O', 'effects-O', 'vary-O', ',-O', 'depending-O', 'on-O', 'the-O', 'duration-O', 'and-O', 'intensity-O', 'of-O', 'hyperprolactinemia-B-Disease', '.-O']
['The-O', 'age-O', ',-O', 'related-O', 'decrease-O', 'in-O', 'hypothalamic-O', 'dopamine-B-Chemical']
['Treatment-O', ',-O', 'related-O', 'disseminated-O', 'necrotizing-O', 'leukoencephalopathy-B-Disease', 'with-O', 'characteristic-O', 'contrast-O', 'enhancement-O', 'of-O', 'the-O', 'white-O', 'matter-O', '.-O']
['This-O', 'report-O', 'describes-O', 'unique-O', 'contrast-O', 'enhancement-O', 'of-O', 'the-O', 'white-O', 'matter-O', 'on-O', 'T1-O', ',', 'weighted-O', 'magnetic-O', 'resonance-O', 'images-O', 'of-O', 'two-O', 'patients-O', 'with-O', 'disseminated-O', 'necrotizing-O', 'leukoencephalopathy-B-Disease', ',', 'which-O', 'developed-O', 'from-O', 'acute-B-Disease', 'lymphoblastic-I-Disease', 'leukemia-I-Disease', 'treated-O', 'with-O', 'high-O', ',', 'dose-O', 'methotrexate-B-Chemical', '.-O']
['In-O', 'both-O', 'patients-O', ',-O', 'the-O', 'enhancement-O', 'was-O', 'more-O', 'pronounced-O', 'near-O', 'the-O', 'base-O', 'of-O', 'the-O', 'brain-O', 'than-O', 'at-O', 'the-O', 'vertex-O', '.-O']
['Necropsy-O', 'of-O', 'the-O', 'first-O', 'case-O', 'revealed-O', 'loss-B-Disease', 'of-O', 'myelination-O', 'and-O', 'necrosis-B-Disease', 'of-O', 'the-O', 'white-O', 'matter-O', '.-O']
['Possible-O', 'mechanisms-O', 'causing-O', 'such-O', 'a-O', 'leukoencephalopathy-B-Disease']
['Thrombotic-B-Disease', 'complications-O', 'in-O', 'acute-B-Disease', 'promyelocytic-I-Disease', 'leukemia-I-Disease', 'during-O', 'all-trans-retinoic-B-Chemical', 'acid-I-Chemical', 'therapy-O', '.-O']
['A-O', 'case-O', 'of-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', ',-O', 'due-O', 'to-O', 'occlusion-O', 'of-O', 'renal-O', 'vessels-O', 'in-O', 'a-O', 'patient-O', 'with-O', 'acute-B-Disease', 'promyelocytic-I-Disease', 'leukemia-I-Disease', '(-O', 'APL-B-Disease', ')-O', 'treated-O', 'with-O', 'all-trans-retinoic-B-Chemical', 'acid-I-Chemical', '(-O', 'ATRA-B-Chemical', ')-O', 'and-O', 'tranexamic-B-Chemical', 'acid-I-Chemical', 'has-O', 'been-O', 'described-O', 'recently-O', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'in-O', 'an-O', 'APL-B-Disease', 'patient-O', 'treated-O', 'with-O', 'ATRA-B-Chemical', 'alone-O', '.-O']
['This-O', 'case-O', 'further-O', 'supports-O', 'the-O', 'concern-O', 'about-O', 'thromboembolic-B-Disease', 'complications-O', 'associated-O', 'with-O', 'ATRA-B-Chemical', 'therapy-O', 'in-O', 'APL-B-Disease', 'patients-O', '.-O']
['The-O', 'patients-O', ',-O', 'a-O', '43-O', '--O', 'year-O', '--O', 'old-O', 'man-O', ',-O', 'presented-O', 'all-O', 'the-O', 'signs-O', 'and-O', 'symptoms-O', 'of-O', 'APL-B-Disease', 'and-O', 'was-O', 'included-O', 'in-O', 'a-O', 'treatment-O', 'protocol-O', 'with-O', 'ATRA-B-Chemical', '.-O']
['After-O', '10-O', 'days-O', 'of-O', 'treatment-O', ',-O', 'he-O', 'developed-O', 'acute-B-Disease', 'renal-B-Disease', 'failure-I-Disease', 'that-O', 'was-O', 'completely-O', 'reversible-O', 'after-O', 'complete-O', 'remission-O', 'of-O', 'APL-B-Disease', 'was-O', 'achieved-O', 'and-O', 'therapy-O', 'discontinued-O', '.-O']
['We-O', 'conclude-O', 'that-O', 'ATRA-B-Chemical', 'is-O', 'a-O', 'valid-O', 'therapeutic-O', 'choice-O', 'for-O', 'patients-O', 'with-O', 'APL-B-Disease', ',', 'although-O', 'the-O', 'procoagulant-O', 'tendency-O', 'is-O', 'not-O', 'completely-O', 'corrected-O', '.-O']
['Thrombotic-B-Disease', 'events-O', ',-O', 'however-O', ',-O', 'could-O', 'be-O', 'avoided-O', 'by-O', 'using-O', 'low-O', ',-O', 'dose-O', 'heparin-B-Chemical']
['Pupillary-O', 'changes-O', 'associated-O', 'with-O', 'the-O', 'development-O', 'of-O', 'stimulant-O', ',-O', 'induced-O', 'mania-B-Disease', ':', 'a-O', 'case-O', 'report-O', '.-O']
['A-O', '30-O', ',-O', 'year-O', ',-O', 'old-O', 'cocaine-B-Chemical', ',-O', 'dependent-O', 'man-O', 'who-O', 'was-O', 'a-O', 'subject-O', 'in-O', 'a-O', 'study-O', 'evaluating-O', 'the-O', 'anticraving-O', 'efficacy-O', 'of-O', 'the-O', 'stimulant-O', 'medication-O', 'diethylpropion-B-Chemical', '(-O', 'DEP-B-Chemical', ')-O', 'became-O', 'manic-B-Disease', 'during-O', 'his-O', 'second-O', 'week-O', 'on-O', 'the-O', 'study-O', 'drug-O', '.-O']
['Pupillometric-O', 'changes-O', 'while-O', 'on-O', 'DEP-B-Chemical', ',-O', 'especially-O', 'changes-O', 'in-O', 'the-O', 'total-O', 'power-O', 'of-O', 'pupillary-O', 'oscillation-O', ',-O', 'were-O', 'dramatically-O', 'different-O', 'than-O', 'those-O', 'observed-O', 'in-O', 'the-O', 'eight-O', 'other-O', 'study-O', 'subjects-O', 'who-O', 'did-O', 'not-O', 'become-O', 'manic-B-Disease', '.-O']
['The-O', 'large-O', 'changes-O', 'in-O', 'total-O', 'power-O', 'of-O', 'pupillary-O', 'oscillation-O', 'occurred-O', 'a-O', 'few-O', 'days-O', 'before-O', 'the-O', 'patient-O', 'became-O', 'fully-O', 'manic-B-Disease', '.-O']
['Such-O', 'medication-O', ',-O', 'associated-O', 'changes-O', 'in-O', 'the-O', 'total-O', 'power-O', 'of-O', 'pupillary-O', 'oscillation-O', 'might-O', 'be-O', 'of-O', 'utility-O', 'in-O', 'identifying-O', 'persons-O', 'at-O', 'risk-O', 'for-O', 'manic-B-Disease']
['The-O', 'negative-O', 'mucosal-O', 'potential-O', ':-O', 'separating-O', 'central-O', 'and-O', 'peripheral-O', 'effects-O', 'of-O', 'NSAIDs-B-Chemical', 'in-O', 'man-O', '.-O']
['OBJECTIVE-O', ':-O', 'We-O', 'wanted-O', 'to-O', 'test-O', 'whether-O', 'assessment-O', 'of-O', 'both-O', 'a-O', 'central-O', 'pain-B-Disease', ',-O', 'related-O', 'signal-O', '(-O', 'chemo-O', ',-O', 'somatosensory-O', 'evoked-O', 'potential-O', ',-O', 'CSSEP-O', ')-O', 'and-O', 'a-O', 'concomitantly-O', 'recorded-O', 'peripheral-O', 'signal-O', '(-O', 'negative-O', 'mucosal-O', 'potential-O', ',-O', 'NMP-O', ')-O', 'allows-O', 'for-O', 'separation-O', 'of-O', 'central-O', 'and-O', 'peripheral-O', 'effects-O', 'of-O', 'NSAIDs-B-Chemical', '.-O']
['For-O', 'this-O', 'purpose-O', ',-O', 'experimental-O', 'conditions-O', 'were-O', 'created-O', 'in-O', 'which-O', 'NSAIDs-B-Chemical', 'had-O', 'previously-O', 'been-O', 'observed-O', 'to-O', 'produce-O', 'effects-O', 'on-O', 'phasic-O', 'and-O', 'tonic-O', 'pain-B-Disease', 'by-O', 'either-O', 'central-O', 'or-O', 'peripheral-O', 'mechanisms-O', '.-O']
['METHODS-O', ':-O', 'According-O', 'to-O', 'a-O', 'double-O', ',-O', 'blind-O', ',-O', 'randomised-O', ',-O', 'controlled-O', ',-O', 'threefold-O', 'cross-O', ',-O', 'over-O', 'design-O', ',-O', '18-O', 'healthy-O', 'subjects-O', '(-O', '11-O', 'males-O', ',-O', '7-O', 'females-O', ';-O', 'mean-O', 'age-O', '26-O', 'years-O', ')-O', 'received-O', 'either-O', 'placebo-O', ',-O', '400-O', 'mg-O', 'ibuprofen-B-Chemical', ',-O', 'or-O', '800-O', 'mg-O', 'ibuprofen-B-Chemical', '.-O']
['Phasic-O', 'pain-B-Disease', 'was-O', 'applied-O', 'by-O', 'means-O', 'of-O', 'short-O', 'pulses-O', 'of-O', 'CO2-B-Chemical', 'to-O', 'the-O', 'nasal-O', 'mucosa-O', '(-O', 'stimulus-O', 'duration-O', '500-O', 'ms-O', ',-O', 'interval-O', 'approximately-O', '60-O', 's-O', ')-O', 'and-O', 'tonic-O', 'pain-B-Disease', 'was-O', 'induced-O', 'in-O', 'the-O', 'nasal-O', 'cavity-O', 'by-O', 'means-O', 'of-O', 'dry-O', 'air-O', 'of-O', 'controlled-O', 'temperature-O', ',-O', 'humidity-O', 'and-O', 'flow-O', 'rate-O', '(-O', '22-O', 'degrees-O', 'C-O', ',-O', '0-O', '%-O', 'relative-O', 'humidity-O', ',-O', '145-O', 'ml-O', '.-O']
['s-O', ',-O', '1-O', ').-O', 'Both-O', 'CSSEPs-O', 'as-O', 'central-O', 'and-O', 'NMPs-O', 'as-O', 'peripheral-O', 'correlates-O', 'of-O', 'pain-B-Disease', 'were-O', 'obtained-O', 'in-O', 'response-O', 'to-O', 'the-O', 'CO2-B-Chemical', 'stimuli-O', '.-O']
['Additionally-O', ',-O', 'the-O', 'subjects-O', 'rated-O', 'the-O', 'intensity-O', 'of-O', 'both-O', 'phasic-O', 'and-O', 'tonic-O', 'pain-B-Disease', 'by-O', 'means-O', 'of-O', 'visual-O', 'analogue-O', 'scales-O', '.-O']
['RESULTS-O', ':', 'As-O', 'described-O', 'earlier-O', ',-O', 'administration-O', 'of-O', 'ibuprofen-B-Chemical', 'was-O', 'followed-O', 'by-O', 'a-O', 'decrease-O', 'in-O', 'tonic-O', 'pain-B-Disease', 'but-O', ',-O', 'relative-O', 'to-O', 'placebo-O', ',-O', 'an-O', 'increase-O', 'in-O', 'correlates-O', 'of-O', 'phasic-O', 'pain-B-Disease', ',-O', 'indicating-O', 'a-O', 'specific-O', 'effect-O', 'of-O', 'ibuprofen-B-Chemical', 'on-O', 'the-O', 'interaction-O', 'between-O', 'the-O', 'pain-B-Disease', 'stimuli-O', 'under-O', 'these-O', 'special-O', 'experimental-O', 'conditions-O', '.-O']
['Based-O', 'on-O', 'the-O', 'similar-O', 'behaviour-O', 'of-O', 'CSSEP-O', 'and-O', 'NMP-O', ',-O', 'it-O', 'was-O', 'concluded-O', 'that-O', 'the-O', 'pharmacological-O', 'process-O', 'underlying-O', 'this-O', 'phenomenon-O', 'was-O', 'localised-O', 'in-O', 'the-O', 'periphery-O', '.-O']
['By-O', 'means-O', 'of-O', 'the-O', 'simultaneous-O', 'recording-O', 'of-O', 'interrelated-O', 'peripheral-O', 'and-O', 'central-O', 'electrophysiologic-O', 'correlates-O', 'of-O', 'nociception-O', ',-O', 'it-O', 'was-O', 'possible-O', 'to-O', 'separate-O', 'central-O', 'and-O', 'peripheral-O', 'effects-O', 'of-O', 'an-O', 'NSAID-B-Chemical', '.-O']
['The-O', 'major-O', 'advantage-O', 'of-O', 'this-O', 'pain-B-Disease', 'model-O', 'is-O', 'the-O', 'possibility-O', 'of-O', 'obtaining-O', 'peripheral-O', 'pain-B-Disease']
['Acute-B-Disease', 'severe-B-Disease', 'depression-I-Disease', 'following-O', 'peri-O', ',', 'operative-O', 'ondansetron-B-Chemical', '.-O']
['A-O', '41-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'with-O', 'a-O', 'strong-O', 'history-O', 'of-O', 'postoperative-B-Disease', 'nausea-I-Disease', 'and-I-Disease', 'vomiting-I-Disease', 'presented-O', 'for-O', 'abdominal-O', 'hysterectomy-O', '3-O', 'months-O', 'after-O', 'a-O', 'previous-O', 'anaesthetic-O', 'where-O', 'ondansetron-B-Chemical', 'prophylaxis-O', 'had-O', 'been-O', 'used-O', '.-O']
['She-O', 'had-O', 'developed-O', 'a-O', 'severe-O', 'acute-O', 'major-B-Disease', 'depression-I-Disease', 'disorder-I-Disease', 'almost-O', 'immediately-O', 'thereafter-O', ',-O', 'possibly-O', 'related-O', 'to-O', 'the-O', 'use-O', 'of-O', 'a-O', 'serotonin-B-Chemical', 'antagonist-O', '.-O']
['Nine-O', 'years-O', 'before-O', 'she-O', 'had-O', 'experienced-O', 'a-O', 'self-O', ',-O', 'limited-O', 'puerperal-O', 'depressive-B-Disease', 'episode-O', '.-O']
['Anaesthesia-O', 'with-O', 'a-O', 'propofol-B-Chemical', 'infusion-O', 'and-O', 'avoidance-O', 'of-O', 'serotonin-B-Chemical', 'antagonists-O', 'provided-O', 'a-O', 'nausea-B-Disease', ',-O', 'free-O', 'postoperative-B-Disease', 'course-O', 'without-O', 'exacerbation-O', 'of-O', 'the-O', 'depression-B-Disease', 'disorder-I-Disease']
['Hypertensive-B-Disease', 'response-O', 'during-O', 'dobutamine-B-Chemical', 'stress-O', 'echocardiography-O', '.-O']
['Among-O', '3-O', ',', '129-O', 'dobutamine-B-Chemical', 'stress-O', 'echocardiographic-O', 'studies-O', ',', 'a-O', 'hypertensive-B-Disease', 'response-O', ',', 'defined-O', 'as-O', 'systolic-O', 'blood-O', 'pressure-O', '(-O', 'BP-O', ')-O', '>-O', 'or-O', '=-O', '220-O', 'mm-O', 'Hg-O', 'and-O', '/-O', 'or-O', 'diastolic-O', 'BP-O', '>-O', 'or-O', '=-O', '110-O', 'mm-O', 'Hg-O', ',-O', 'occurred-O', 'in-O', '30-O', 'patients-O', '(-O', '1-O', ').-O', 'Patients-O', 'with-O', 'this-O', 'response-O', 'more-O', 'often-O', 'had-O', 'a-O', 'history-O', 'of-O', 'hypertension-B-Disease', 'and-O', 'had-O', 'higher-O', 'resting-O', 'systolic-O', 'and-O', 'diastolic-O', 'BP-O', 'before-O', 'dobutamine-B-Chemical']
['Continuously-O', 'nebulized-O', 'albuterol-B-Chemical', 'in-O', 'severe-O', 'exacerbations-O', 'of-O', 'asthma-B-Disease', 'in-O', 'adults-O', ':-O', 'a-O', 'case-O', ',-O', 'controlled-O', 'study-O', '.-O']
['A-O', 'retrospective-O', ',-O', 'case-O', ',-O', 'controlled-O', 'analysis-O', 'comparing-O', 'patients-O', 'admitted-O', 'to-O', 'a-O', 'medical-O', 'intensive-O', 'care-O', 'unit-O', 'with-O', 'severe-O', 'exacerbations-O', 'of-O', 'asthma-B-Disease', 'who-O', 'received-O', 'continuously-O', 'nebulized-O', 'albuterol-B-Chemical', '(-O', 'CNA-O', ')', 'versus-O', 'intermittent-O', 'albuterol-B-Chemical', '(-O', 'INA-O', ')', 'treatments-O', 'is-O', 'reported-O', '.-O']
['Forty-O', 'matched-O', 'pairs-O', 'of-O', 'patients-O', 'with-O', 'asthma-B-Disease', 'are-O', 'compared-O', '.-O']
['CNA-B-Chemical', 'was-O', 'administered-O', 'for-O', 'a-O', 'mean-O', 'of-O', '11-O', '+-O', '10-O', 'hr-O', '.-O']
['The-O', 'incidence-O', 'of-O', 'cardiac-B-Disease', 'dysrhythmias-I-Disease', 'was-O', 'similar-O', 'between-O', 'groups-O', '.-O']
['Symptomatic-O', 'hypokalemia-B-Disease']
['Hyperosmolar-B-Disease', 'nonketotic-B-Disease', 'coma-B-Disease', 'precipitated-O', 'by-O', 'lithium-B-Chemical', ',-O', 'induced-O', 'nephrogenic-B-Disease', 'diabetes-B-Disease', 'insipidus-I-Disease', '.-O']
['A-O', '45-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', ',-O', 'with-O', 'a-O', '10-O', ',-O', 'year-O', 'history-O', 'of-O', 'manic-B-Disease', 'depression-I-Disease', 'treated-O', 'with-O', 'lithium-B-Chemical', ',-O', 'was-O', 'admitted-O', 'with-O', 'hyperosmolar-O', 'nonketotic-O', 'coma-B-Disease', '.-O']
['He-O', 'gave-O', 'a-O', 'five-O', 'year-O', 'history-O', 'of-O', 'polyuria-B-Disease', 'and-O', 'polydipsia-B-Disease', ',-O', 'during-O', 'which-O', 'time-O', 'urinalysis-O', 'had-O', 'been-O', 'negative-O', 'for-O', 'glucose-B-Chemical', '.-O']
['After-O', 'recovery-O', 'from-O', 'hyperglycaemia-B-Disease', ',-O', 'he-O', 'remained-O', 'polyuric-B-Disease', 'despite-O', 'normal-O', 'blood-O', 'glucose-B-Chemical', 'concentrations-O', ';-O', 'water-O', 'deprivation-O', 'testing-O', 'indicated-O', 'nephrogenic-O', 'diabetes-B-Disease', 'insipidus-I-Disease', ',-O', 'likely-O', 'to-O', 'be-O', 'lithium-B-Chemical', ',-O', 'induced-O', '.-O']
['We-O', 'hypothesize-O', 'that-O', 'when-O', 'this-O', 'man-O', 'developed-O', 'type-O', '2-O', 'diabetes-B-Disease', ',-O', 'chronic-O', 'polyuria-B-Disease', 'due-O', 'to-O', 'nephrogenic-O', 'diabetes-B-Disease', 'insipidus-I-Disease', 'was-O', 'sufficient-O', 'to-O', 'precipitate-O', 'hyperosmolar-O', 'dehydration-B-Disease']
['Effects-O', 'of-O', 'the-O', 'intracoronary-O', 'infusion-O', 'of-O', 'cocaine-B-Chemical', 'on-O', 'left-O', 'ventricular-O', 'systolic-O', 'and-O', 'diastolic-O', 'function-O', 'in-O', 'humans-O', '.-O']
['BACKGROUND-O', ':-O', 'In-O', 'dogs-O', ',-O', 'a-O', 'large-O', 'amount-O', 'of-O', 'intravenous-O', 'cocaine-B-Chemical', 'causes-O', 'a-O', 'profound-O', 'deterioration-O', 'of-O', 'left-O', 'ventricular-O', '(LV)-O', 'systolic-O', 'function-O', 'and-O', 'an-O', 'increase-O', 'in-O', 'LV-O', 'end-O', ',-O', 'diastolic-O', 'pressure-O', '.-O']
['This-O', 'study-O', 'was-O', 'done-O', 'to-O', 'assess-O', 'the-O', 'influence-O', 'of-O', 'a-O', 'high-O', 'intracoronary-O', 'cocaine-B-Chemical', 'concentration-O', 'on-O', 'LV-O', 'systolic-O', 'and-O', 'diastolic-O', 'function-O', 'in-O', 'humans-O', '.-O']
['METHODS-O', 'AND-O', 'RESULTS-O', ':-O', 'In-O', '20-O', 'patients-O', '(-O', '14-O', 'men-O', 'and-O', '6-O', 'women-O', 'aged-O', '39-O', 'to-O', '72-O', 'years-O', ')-O', 'referred-O', 'for-O', 'cardiac-O', 'catheterization-O', 'for-O', 'the-O', 'evaluation-O', 'of-O', 'chest-O', 'pain-O', ',-O', 'we-O', 'measured-O', 'heart-O', 'rate-O', ',-O', 'systemic-O', 'arterial-O', 'pressure-O', ',-O', 'LV-O', 'pressure-O', 'and-O', 'its-O', 'first-O', 'derivative-O', '(-O', 'dP-O', '/-O', 'dt-O', ')-O', 'and-O', 'LV-O', 'volumes-O', 'and-O', 'ejection-O', 'fraction-O', 'before-O', 'and-O', 'during-O', 'the-O', 'final-O', '2-O', 'to-O', '3-O', 'minutes-O', 'of-O', 'a-O', '15-O', ',-O', 'minute-O', 'intracoronary-O', 'infusion-O', 'of-O', 'saline-O', '(-O', 'n-O', '=', '10-O', ',-O', 'control-O', 'subjects-O', ')-O', 'or-O', 'cocaine-B-Chemical', 'hydrochloride-O', '1-O', 'mg-O', '/-O', 'min-O', '(-O', 'n-O', '=', '10-O', ').-O', 'No-O', 'variable-O', 'changed-O', 'with-O', 'saline-O', '.-O']
['With-O', 'cocaine-B-Chemical', ',-O', 'the-O', 'drug-O', 'concentration-O', 'in-O', 'blood-O', 'obtained-O', 'from-O', 'the-O', 'coronary-O', 'sinus-O', 'was-O', '3-O', '.-O']
['0-O', '+-O', '0-O', '.-O']
['4-O', '(-O', 'mean-O', '+-O', 'SD-O', ')-O', 'mg-O', '/-O', 'L-O', ',-O', 'similar-O', 'in-O', 'magnitude-O', 'to-O', 'the-O', 'blood-O', 'cocaine-B-Chemical', 'concentration-O', 'reported-O', 'in-O', 'abusers-O', 'dying-O', 'of-O', 'cocaine-B-Chemical', 'intoxication-O', '.-O']
['Cocaine-B-Chemical', 'induced-O', 'no-O', 'significant-O', 'change-O', 'in-O', 'heart-O', 'rate-O', ',-O', 'LV-O', 'dP-O', '/-O', 'dt-O', '(-O', 'positive-O', 'or-O', 'negative-O', ')-O', ',O', 'or-O', 'LV-O', 'end-O', ',-O', 'diastolic-O', 'volume-O', ',-O', 'but-O', 'it-O', 'caused-O', 'an-O', 'increase-O', 'in-O', 'systolic-O', 'and-O', 'mean-O', 'arterial-O', 'pressures-O', ',-O', 'LV-O', 'end-O', ',-O', 'diastolic-O', 'pressure-O', ',-O', 'and-O', 'LV-O', 'end-O', ',-O', 'systolic-O', 'volume-O', ',-O', 'as-O', 'well-O', 'as-O', 'a-O', 'decrease-O', 'in-O', 'LV-O', 'ejection-O', 'fraction-O', '.-O']
['CONCLUSIONS-O', ':-O', 'In-O', 'humans-O', ',-O', 'the-O', 'intracoronary-O', 'infusion-O', 'of-O', 'cocaine-B-Chemical', 'sufficient-O', 'in-O', 'amount-O', 'to-O', 'achieve-O', 'a-O', 'high-O', 'drug-O', 'concentration-O', 'in-O', 'coronary-O', 'sinus-O', 'blood-O', 'causes-O', 'a-O', 'deterioration-O', 'of-O', 'LV-O', 'systolic-O', 'and-O', 'diastolic-O', 'performance-O']
['Heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', ',-O', 'paradoxical-O', 'thromboembolism-B-Disease', ',-O', 'and-O', 'other-O', 'side-O', 'effects-O', 'of-O', 'heparin-B-Chemical', 'therapy-O', '.-O']
['Although-O', 'several-O', 'new-O', 'anticoagulant-O', 'drugs-O', 'are-O', 'in-O', 'development-O', ',-O', 'heparin-B-Chemical', 'remains-O', 'the-O', 'drug-O', 'of-O', 'choice-O', 'for-O', 'most-O', 'anticoagulation-O', 'needs-O', '.-O']
['The-O', 'clinical-O', 'effects-O', 'of-O', 'heparin-B-Chemical', 'are-O', 'meritorious-O', ',-O', 'but-O', 'side-O', 'effects-O', 'do-O', 'exist-O', '.-O']
['Important-O', 'untoward-O', 'effects-O', 'of-O', 'heparin-B-Chemical', 'therapy-O', 'including-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', ',-O', 'heparin-B-Chemical', ',-O', 'associated-O', 'osteoporosis-B-Disease', ',-O', 'eosinophilia-B-Disease', ',-O', 'skin-O', 'reactions-O', ',-O', 'allergic-B-Disease', 'reactions-O', 'other-O', 'than-O', 'thrombocytopenia-B-Disease', 'and-O', 'alopecia-B-Disease']
['Nonopaque-O', 'crystal-O', 'deposition-O', 'causing-O', 'ureteric-O', 'obstruction-B-Disease', 'in-O', 'patients-O', 'with-O', 'HIV-B-Disease', 'undergoing-O', 'indinavir-B-Chemical', 'therapy-O', '.-O']
['OBJECTIVE-O', ':-O', 'We-O', 'describe-O', 'the-O', 'unique-O', 'CT-O', 'features-O', 'of-O', 'ureteric-B-Disease', 'calculi-I-Disease', 'in-O', 'six-O', 'HIV-infected-B-Disease', 'patients-O', 'receiving-O', 'indinavir-B-Chemical', ',-O', 'the-O', 'most-O', 'commonly-O', 'used-O', 'HIV-O', 'protease-O', 'inhibitor-O', ',-O', 'which-O', 'is-O', 'associated-O', 'with-O', 'an-O', 'increased-O', 'incidence-O', 'of-O', 'urolithiasis-B-Disease', '.-O']
['CONCLUSION-O', ':-O', 'Ureteric-B-Disease', 'obstruction-I-Disease', 'caused-O', 'by-O', 'precipitated-O', 'indinavir-B-Chemical', 'crystals-O', 'may-O', 'be-O', 'difficult-O', 'to-O', 'diagnose-O', 'with-O', 'unenhanced-O', 'CT-O', '.-O']
['The-O', 'calculi-B-Disease', 'are-O', 'not-O', 'opaque-O', ',-O', 'and-O', 'secondary-O', 'signs-O', 'of-O', 'obstruction-B-Disease', 'may-O', 'be-O', 'absent-O', 'or-O', 'minimal-O', 'and-O', 'should-O', 'be-O', 'sought-O', 'carefully-O', '.-O']
['Images-O', 'may-O', 'need-O', 'to-O', 'be-O', 'obtained-O', 'using-O', 'i-O']
['v-O', '.-O']
['contrast-O', 'material-O', 'to-O', 'enable-O', 'diagnosis-O', 'of-O', 'ureteric-O', 'stones-O', 'or-O', 'obstruction-O', 'in-O', 'patients-O', 'with-O', 'HIV-B-Disease', 'infection-O', 'who-O', 'receive-O', 'indinavir-B-Chemical']
['Ischemic-B-Disease', 'colitis-I-Disease', 'and-O', 'sumatriptan-B-Chemical', 'use-O', '.-O']
['Sumatriptan-B-Chemical', 'succinate-I-Chemical', ',-O', 'a-O', 'serotonin-B-Chemical', ',-O', '1-O', '(-O', '5-hydroxytryptamine-B-Chemical', ',-O', '1-O', ')-O', 'receptor-O', 'agonist-O', ',-O', 'is-O', 'an-O', 'antimigraine-O', 'drug-O', 'that-O', 'is-O', 'reported-O', 'to-O', 'act-O', 'by-O', 'selectively-O', 'constricting-O', 'intracranial-O', 'arteries-O', '.-O']
['Recently-O', ',-O', 'vasopressor-O', 'responses-O', 'that-O', 'are-O', 'distinct-O', 'from-O', 'the-O', 'cranial-O', 'circulation-O', 'have-O', 'been-O', 'demonstrated-O', 'to-O', 'occur-O', 'in-O', 'the-O', 'systemic-O', ',-O', 'pulmonary-O', ',-O', 'and-O', 'coronary-O', 'circulations-O', '.-O']
['Cases-O', 'have-O', 'been-O', 'published-O', 'of-O', 'coronary-O', 'vasospasm-B-Disease', ',-O', 'myocardial-B-Disease', 'ischemia-I-Disease', ',-O', 'and-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'occurring-O', 'after-O', 'sumatriptan-B-Chemical', 'use-O', '.-O']
['We-O', 'report-O', 'on-O', 'the-O', 'development-O', 'of-O', '8-O', 'serious-O', 'cases-O', 'of-O', 'ischemic-B-Disease', 'colitis-B-Disease', 'in-O', 'patients-O', 'with-O', 'migraine-B-Disease', 'treated-O', 'with-O', 'sumatriptan-B-Chemical']
['Pallidotomy-B-Disease', 'with-O', 'the-O', 'gamma-O', 'knife-O', ':-O', 'a-O', 'positive-O', 'experience-O', '.-O']
['51-O', 'patients-O', 'with-O', 'medically-O', 'refractory-O', 'Parkinson-B-Disease', 'disease-I-Disease', 'underwent-O', 'stereotactic-O', 'posteromedial-O', 'pallidotomy-O', 'between-O', 'August-O', '1993-O', 'and-O', 'February-O', '1997-O', 'for-O', 'treatment-O', 'of-O', 'bradykinesia-B-Disease', ',', 'rigidity-B-Disease', ',', 'and-O', 'L-DOPA-B-Chemical', ',', 'induced-O', 'dyskinesias-B-Disease', '.-O']
['In-O', '29-O', 'patients-O', ',-O', 'the-O', 'pallidotomies-O', 'were-O', 'performed-O', 'with-O', 'the-O', 'Leksell-O', 'Gamma-O', 'Knife-O', 'and-O', 'in-O', '22-O', 'they-O', 'were-O', 'performed-O', 'with-O', 'the-O', 'standard-O', 'radiofrequency-O', '(-O', 'RF-O', ')-O', 'method-O', '.-O']
['Clinical-O', 'assessment-O', 'as-O', 'well-O', 'as-O', 'blinded-O', 'ratings-O', 'of-O', 'Unified-O', 'Parkinson-B-Disease', 'Disease-I-Disease', 'Rating-O', 'Scale-O', '(', 'UPDRS-O', ')', 'scores-O', 'were-O', 'carried-O', 'out-O', 'pre-O', ',-O', 'and-O', 'postoperatively-O', '.-O']
['Mean-O', 'follow-O', ',-O', 'up-O', 'time-O', 'is-O', '20-O', '.-O']
['6-O', 'months-O', '(-O', 'range-O', '6-O', ',-O', '48-O', ')-O', 'and-O', 'all-O', 'except-O', '4-O', 'patients-O', 'have-O', 'been-O', 'followed-O', 'more-O', 'than-O', 'one-O', 'year-O', '.-O']
['85-O', 'percent-O', 'of-O', 'patients-O', 'with-O', 'dyskinesias-B-Disease', 'were-O', 'relieved-O', 'of-O', 'symptoms-O', ',-O', 'regardless-O', 'of-O', 'whether-O', 'the-O', 'pallidotomies-O', 'were-O', 'performed-O', 'with-O', 'the-O', 'Gamma-O', 'Knife-O', 'or-O', 'radiofrequency-O', 'methods-O', '.-O']
['About-O', '2-O', '/-O', '3-O', 'of-O', 'the-O', 'patients-O', 'in-O', 'both-O', 'Gamma-O', 'Knife-O', 'and-O', 'radiofrequency-O', 'groups-O', 'showed-O', 'improvements-O', 'in-O', 'bradykinesia-B-Disease', 'and-O', 'rigidity-B-Disease', ',-O', 'although-O', 'when-O', 'considered-O', 'as-O', 'a-O', 'group-O', 'neither-O', 'the-O', 'Gamma-O', 'Knife-O', 'nor-O', 'the-O', 'radiofrequency-O', 'group-O', 'showed-O', 'statistically-O', 'significant-O', 'improvements-O', 'in-O', 'UPDRS-O', 'scores-O', '.-O']
['One-O', 'patient-O', 'in-O', 'the-O', 'Gamma-O', 'Knife-O', 'group-O', '(-O', '3-O', '.-O']
['4-O', ')-O', 'developed-O', 'a-O', 'homonymous-O', 'hemianopsia-B-Disease', '9-O', 'months-O', 'following-O', 'treatment-O', 'and-O', '5-O', 'patients-O', '(-O', '27-O', '.-O']
['7-O', ')-O', 'in-O', 'the-O', 'radiofrequency-O', 'group-O', 'became-O', 'transiently-O', 'confused-B-Disease', 'postoperatively-O', '.-O']
['No-O', 'other-O', 'complications-O', 'were-O', 'seen-O', '.-O']
['Gamma-O', 'Knife-O', 'pallidotomy-O', 'is-O', 'as-O', 'effective-O', 'as-O', 'radiofrequency-O', 'pallidotomy-O', 'in-O', 'controlling-O', 'certain-O', 'of-O', 'the-O', 'symptoms-O', 'of-O', 'Parkinson-B-Disease', 'disease-I-Disease', '.-O']
['It-O', 'may-O', 'be-O', 'the-O', 'only-O', 'practical-O', 'technique-O', 'available-O', 'in-O', 'certain-O', 'patients-O', ',-O', 'such-O', 'as-O', 'those-O', 'who-O', 'take-O', 'anticoagulants-O', ',-O', 'have-O', 'bleeding-B-Disease']
['Neuroleptic-O', 'malignant-B-Disease', 'syndrome-O', 'and-O', 'methylphenidate-B-Chemical', '.-O']
['A-O', '1-O', ',-O', 'year-O', ',-O', 'old-O', 'female-O', 'presented-O', 'with-O', 'neuroleptic-O', 'malignant-O', 'syndrome-B-Disease', 'probably-O', 'caused-O', 'by-O', 'methylphenidate-B-Chemical', '.-O']
['She-O', 'had-O', 'defects-O', 'in-O', 'the-O', 'supratentorial-O', 'brain-O', 'including-O', 'the-O', 'basal-O', 'ganglia-I-Disease', 'and-O', 'the-O', 'striatum-I-Disease', '(-O', 'multicystic-O', 'encephalomalacia-I-Disease', ')-O', 'due-O', 'to-O', 'severe-O', 'perinatal-O', 'hypoxic-ischemic-O', 'encephalopathy-B-Disease', ',-O', 'which-O', 'was-O', 'considered-O', 'to-O', 'be-O', 'a-O', 'possible-O', 'predisposing-O', 'factor-O', 'causing-O', 'neuroleptic-O', 'malignant-O', 'syndrome-B-Disease', '.-O']
['A-O', 'dopaminergic-O', 'blockade-O', 'mechanism-O', 'generally-O', 'is-O', 'accepted-O', 'as-O', 'the-O', 'pathogenesis-O', 'of-O', 'this-O', 'syndrome-B-Disease', '.-O']
['However-O', ',-O', 'methylphenidate-B-Chemical', 'is-O', 'a-O', 'dopamine-B-Chemical', 'agonist-O', 'via-O', 'the-O', 'inhibition-O', 'of-O', 'uptake-O', 'of-O', 'dopamine-B-Chemical', ',-O', 'and-O', 'therefore-O', 'dopaminergic-O', 'systems-O', 'in-O', 'the-O', 'brainstem-O', '(-O', 'mainly-O', 'the-O', 'midbrain-O', ')-O', 'and-O', 'the-O', 'spinal-O', 'cord-O', 'were-O', 'unlikely-O', 'to-O', 'participate-O', 'in-O', 'the-O', 'onset-O', 'of-O', 'this-O', 'syndrome-O', '.-O']
['A-O', 'relative-O', 'gamma-aminobutyric-B-Chemical', 'acid-I-Chemical', ',-O', 'ergic-O', 'deficiency-O', 'might-O', 'occur-O', 'because-O', 'diazepam-B-Chemical', ',-O', 'a-O', 'gamma-aminobutyric-B-Chemical', 'acid-I-Chemical', ',-O', 'mimetic-O', 'agent-O', ',-O', 'was-O', 'strikingly-O', 'effective-O', '.-O']
['This-O', 'is-O', 'the-O', 'first-O', 'reported-O', 'patient-O', 'with-O', 'neuroleptic-B-Disease', 'malignant-B-Disease', 'syndrome-I-Disease', 'probably-O', 'caused-O', 'by-O', 'methylphenidate-B-Chemical']
['Differential-O', 'effects-O', 'of-O', '17alpha-ethinylestradiol-B-Chemical', 'on-O', 'the-O', 'neutral-O', 'and-O', 'acidic-O', 'pathways-O', 'of-O', 'bile-O', 'salt-B-Chemical', 'synthesis-O', 'in-O', 'the-O', 'rat-O', '.-O']
['Effects-O', 'of-O', '17alpha-ethinylestradiol-B-Chemical', '(-O', 'EE-B-Chemical', ')-O', 'on-O', 'the-O', 'neutral-O', 'and-O', 'acidic-O', 'biosynthetic-O', 'pathways-O', 'of-O', 'bile-O', 'salt-O', '(-O', 'BS-O', ')-O', 'synthesis-O', 'were-O', 'evaluated-O', 'in-O', 'rats-O', 'with-O', 'an-O', 'intact-O', 'enterohepatic-O', 'circulation-O', 'and-O', 'in-O', 'rats-O', 'with-O', 'long-O', ',-O', 'term-O', 'bile-O', 'diversion-O', 'to-O', 'induce-O', 'BS-O', 'synthesis-O', '.-O']
['For-O', 'this-O', 'purpose-O', ',-O', 'bile-O', 'salt-O', 'pool-O', 'composition-O', ',-O', 'synthesis-O', 'of-O', 'individual-O', 'BS-O', 'in-O', 'vivo-O', ',-O', 'hepatic-O', 'activities-O', ',-O', 'and-O', 'expression-O', 'levels-O', 'of-O', 'cholesterol-O', '7alpha-O', ',-O', 'hydroxylase-O', '(-O', 'CYP7A-O', ')-O', 'and-O', 'sterol-O', '27-O', ',-O', 'hydroxylase-O', '(-O', 'CYP27-O', ')-O', 'as-O', 'well-O', 'as-O', 'of-O', 'other-O', 'enzymes-O', 'involved-O', 'in-O', 'BS-O', 'synthesis-O', ',-O', 'were-O', 'analyzed-O', 'in-O', 'rats-O', 'treated-O', 'with-O', 'EE-B-Chemical', '(-O', '5-O', 'mg-O', '/-O', 'kg-O', ',-O', '3-O', 'days-O', ')-O', 'or-O', 'its-O', 'vehicle-O', '.-O']
['BS-O', 'pool-O', 'size-O', 'was-O', 'decreased-O', 'by-O', '27-O', '%-O', 'but-O', 'total-O', 'BS-O', 'synthesis-O', 'was-O', 'not-O', 'affected-O', 'by-O', 'EE-O', 'in-O', 'intact-O', 'rats-O', '.-O']
['Synthesis-O', 'of-O', 'cholate-B-Chemical', 'was-O', 'reduced-O', 'by-O', '68-O', '%-O', 'in-O', 'EE-B-Chemical', ',-O', 'treated-O', 'rats-O', ',-O', 'while-O', 'that-O', 'of-O', 'chenodeoxycholate-B-Chemical', 'was-O', 'increased-O', 'by-O', '60-O', '.-O', 'The-O', 'recently-O', 'identified-O', 'Delta22-O', ',-O', 'isomer-O', 'of-O', 'beta-O', ',-O', 'muricholate-B-Chemical', 'contributed-O', 'for-O', '5-O', '.-O']
['4-O', '%-O', 'and-O', '18-O', '.-O']
['3-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'to-O', 'the-O', 'pool-O', 'in-O', 'control-O', 'and-O', 'EE-B-Chemical', ',-O', 'treated-O', 'rats-O', ',-O', 'respectively-O', ',-O', 'but-O', 'could-O', 'not-O', 'be-O', 'detected-O', 'in-O', 'bile-O', 'after-O', 'exhaustion-O', 'of-O', 'the-O', 'pool-O', '.-O']
['A-O', 'clear-O', 'reduction-O', 'of-O', 'BS-O', 'synthesis-O', 'was-O', 'found-O', 'in-O', 'bile-O', ',-O', 'diverted-O', 'rats-O', 'treated-O', 'with-O', 'EE-B-Chemical', ',-O', 'yet-O', 'biliary-O', 'BS-O', 'composition-O', 'was-O', 'only-O', 'minimally-O', 'affected-O', '.-O']
['Activity-O', 'of-O', 'CYP7A-O', 'was-O', 'decreased-O', 'by-O', 'EE-B-Chemical', 'in-O', 'both-O', 'intact-O', 'and-O', 'bile-O', ',-O', 'diverted-O', 'rats-O', ',-O', 'whereas-O', 'the-O', 'activity-O', 'of-O', 'the-O', 'CYP27-O', 'was-O', 'not-O', 'affected-O', '.-O']
['Hepatic-O', 'mRNA-O', 'levels-O', 'of-O', 'CYP7A-O', 'were-O', 'significantly-O', 'reduced-O', 'by-O', 'EE-B-Chemical', 'in-O', 'bile-O', ',-O', 'diverted-O', 'rats-O', 'only-O', ';-O', 'CYP27-O', 'mRNA-O', 'levels-O', 'were-O', 'not-O', 'affected-O', 'by-O', 'EE-B-Chemical', '.-O']
['In-O', 'addition-O', ',-O', 'mRNA-O', 'levels-O', 'of-O', 'sterol-O', '12alpha-O', ',-O', 'hydroxylase-O', 'and-O', 'lithocholate-O', '6beta-O', ',-O', 'hydroxylase-O', 'were-O', 'increased-O', 'by-O', 'bile-O', 'diversion-O', 'and-O', 'suppressed-O', 'by-O', 'EE-B-Chemical', '.-O']
['This-O', 'study-O', 'shows-O', 'that-O', '17alpha-ethinylestradiol-B-Chemical', '(-O', 'EE-B-Chemical', ')-O', 'induced-O', 'intrahepatic-B-Disease', 'cholestasis-B-Disease', 'in-O', 'rats-O', 'is-O', 'associated-O', 'with-O', 'selective-O', 'inhibition-O', 'of-O', 'the-O', 'neutral-O', 'pathway-O', 'of-O', 'bile-O', 'salt-O', '(-O', 'BS-O', ')-O', 'synthesis-O', '.-O']
['Simultaneous-O', 'impairment-O', 'of-O', 'other-O', 'enzymes-O', 'in-O', 'the-O', 'BS-O', 'biosynthetic-O', 'pathways-O', 'may-O', 'contribute-O', 'to-O', 'overall-O', 'effects-O', 'of-O', 'EE-B-Chemical', 'on-O', 'BS-O']
['Glibenclamide-B-Chemical', ',-O', 'sensitive-O', 'hypotension-B-Disease', 'produced-O', 'by-O', 'helodermin-B-Chemical', 'assessed-O', 'in-O', 'the-O', 'rat-O', '.-O']
['The-O', 'effects-O', 'of-O', 'helodermin-B-Chemical', ',-O', 'a-O', 'basic-O', '35-O', 'amino-O', 'acid-O', 'peptide-O', 'isolated-O', 'from-O', 'the-O', 'venom-O', 'of-O', 'a-O', 'lizard-O', 'salivary-O', 'gland-O', ',-O', 'on-O', 'arterial-O', 'blood-O', 'pressure-O', 'and-O', 'heart-O', 'rate-O', 'were-O', 'examined-O', 'in-O', 'the-O', 'rat-O', ',-O', 'focusing-O', 'on-O', 'the-O', 'possibility-O', 'that-O', 'activation-O', 'of-O', 'ATP-B-Chemical', 'sensitive-O', 'K-O', '+(-O', 'K-O', '(-O', 'ATP-B-Chemical', '))', 'channels-O', 'is-O', 'involved-O', 'in-O', 'the-O', 'responses-O', '.-O']
['The-O', 'results-O', 'were-O', 'also-O', 'compared-O', 'with-O', 'those-O', 'of-O', 'vasoactive-O', 'intestinal-O', 'polypeptide-O', '(-O', 'VIP-O', ').-O', 'Helodermin-B-Chemical', 'produced-O', 'hypotension-B-Disease', 'in-O', 'a-O', 'dose-O', ',-O', 'dependent-O', 'manner-O', 'with-O', 'approximately-O', 'similar-O', 'potency-O', 'and-O', 'duration-O', 'to-O', 'VIP-B-Chemical', '.-O']
['Hypotension-B-Disease', 'induced-O', 'by-O', 'both-O', 'peptides-O', 'was-O', 'significantly-O', 'attenuated-O', 'by-O', 'glibenclamide-B-Chemical', ',-O', 'which-O', 'abolished-O', 'a-O', 'levcromakalim-B-Chemical', ',-O', 'produced-O', 'decrease-O', 'in-O', 'arterial-O', 'blood-O', 'pressure-O', '.-O']
['Oxyhemoglobin-B-Chemical', 'did-O', 'not-O', 'affect-O', 'helodermin-B-Chemical', ',-O', 'induced-O', 'hypotension-B-Disease', ',-O', 'whereas-O', 'it-O', 'shortened-O', 'the-O', 'duration-O', 'of-O', 'acetylcholine-B-Chemical', '(-O', 'ACh-B-Chemical', ')-O', 'produced-O', 'hypotension-B-Disease', '.-O']
['These-O', 'findings-O', 'suggest-O', 'that-O', 'helodermin-B-Chemical', ',-O', 'produced-O', 'hypotension-B-Disease', 'is-O', 'partly-O', 'attributable-O', 'to-O', 'the-O', 'activation-O', 'of-O', 'glibenclamide-B-Chemical', ',-O', 'sensitive-O', 'K-B-Chemical', '+-O', 'channels-O', '(-O', 'K-O', '(-O', 'ATP-B-Chemical', ')--O', 'channels-O', '),', 'which-O', 'presumably-O', 'exist-O', 'on-O', 'arterial-O', 'smooth-O', 'muscle-O', 'cells-O', '.-O']
['EDRF-O', '(-O', 'endothelium-O', ',-O', 'derived-O', 'relaxing-O', 'factor-O', ')-O', '/-O', 'nitric-B-Chemical', 'oxide-I-Chemical', 'does-O', 'not-O', 'seem-O', 'to-O', 'play-O', 'an-O', 'important-O', 'role-O', 'in-O', 'the-O', 'peptide-O', ',-O', 'produced-O', 'hypotension-B-Disease']
['Long-O', ',-O', 'term-O', 'efficacy-O', 'and-O', 'adverse-O', 'event-O', 'of-O', 'nifedipine-B-Chemical', 'sustained-O', ',-O', 'release-O', 'tablets-O', 'for-O', 'cyclosporin-B-Chemical', 'A-I-Chemical', ',-O', 'induced-O', 'hypertension-B-Disease', 'in-O', 'patients-O', 'with-O', 'psoriasis-B-Disease', '.-O']
['Thirteen-O', 'psoriatic-O', 'patients-O', 'with-O', 'hypertension-B-Disease', 'during-O', 'the-O', 'course-O', 'of-O', 'cyclosporin-B-Chemical', 'A-I-Chemical', 'therapy-O', 'were-O', 'treated-O', 'for-O', '25-O', 'months-O', 'with-O', 'a-O', 'calcium-B-Chemical', 'channel-O', 'blocker-O', ',-O', 'sustained-O', ',-O', 'release-O', 'nifedipine-B-Chemical', ',-O', 'to-O', 'study-O', 'the-O', 'clinical-O', 'antihypertensive-O', 'effects-O', 'and-O', 'adverse-O', 'events-O', 'during-O', 'treatment-O', 'with-O', 'both-O', 'drugs-O', '.-O']
['Seven-O', 'of-O', 'the-O', '13-O', 'patients-O', 'had-O', 'exhibited-O', 'a-O', 'subclinical-O', 'hypertensive-B-Disease', 'state-O', 'before-O', 'cyclosporin-B-Chemical', 'A-I-Chemical', 'therapy-O', '.-O']
['Both-O', 'systolic-O', 'and-O', 'diastolic-O', 'blood-O', 'pressures-O', 'of-O', 'these-O', '13-O', 'patients-O', 'were-O', 'decreased-O', 'significantly-O', 'after-O', '4-O', 'weeks-O', 'of-O', 'nifedipine-B-Chemical', 'therapy-O', ',-O', 'and-O', 'blood-O', 'pressure-O', 'was-O', 'maintained-O', 'within-O', 'the-O', 'normal-O', 'range-O', 'thereafter-O', 'for-O', '25-O', 'months-O', '.-O']
['The-O', 'adverse-O', 'events-O', 'during-O', 'combined-O', 'therapy-O', 'with-O', 'cyclosporin-B-Chemical', 'A-I-Chemical', 'and-O', 'nifedipine-B-Chemical', 'included-O', 'an-O', 'increase-O', 'in-O', 'blood-O', 'urea-B-Chemical', 'nitrogen-B-Chemical', 'levels-O', 'in-O', '9-O', 'of-O', 'the-O', '13-O', 'patients-O', 'and-O', 'development-O', 'of-O', 'gingival-O', 'hyperplasia-B-Disease', 'in-O', '2-O', 'of-O', 'the-O', '13-O', 'patients-O', '.-O']
['Our-O', 'findings-O', 'indicate-O', 'that-O', 'sustained-O', ',-O', 'release-O', 'nifedipine-B-Chemical', 'is-O', 'useful-O', 'for-O', 'hypertensive-B-Disease', 'psoriatic-B-Disease', 'patients-O', 'under-O', 'long-O', ',-O', 'term-O', 'treatment-O', 'with-O', 'cyclosporin-B-Chemical', 'A-I-Chemical', ',-O', 'but-O', 'that-O', 'these-O', 'patients-O', 'should-O', 'be-O', 'monitored-O', 'for-O', 'gingival-O', 'hyperplasia-B-Disease']
['Torsade-B-Disease', 'de-I-Disease', 'pointes-I-Disease', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'during-O', 'low-O', 'dose-O', 'intermittent-O', 'dobutamine-B-Chemical', 'treatment-O', 'in-O', 'a-O', 'patient-O', 'with-O', 'dilated-B-Disease', 'cardiomyopathy-I-Disease', 'and-O', 'congestive-B-Disease', 'heart-I-Disease', 'failure-I-Disease', '.-O']
['The-O', 'authors-O', 'describe-O', 'the-O', 'case-O', 'of-O', 'a-O', '56-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'with-O', 'chronic-O', ',-O', 'severe-O', 'heart-O', 'failure-B-Disease', 'secondary-O', 'to-O', 'dilated-B-Disease', 'cardiomyopathy-I-Disease', 'and-O', 'absence-O', 'of-O', 'significant-O', 'ventricular-O', 'arrhythmias-O', 'who-O', 'developed-O', 'QT-O', 'prolongation-B-Disease', 'and-O', 'torsade-B-Disease', 'de-O', 'pointes-I-Disease', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'during-O', 'one-O', 'cycle-O', 'of-O', 'intermittent-O', 'low-O', 'dose-O', '(-O', '2-O', '.-O']
['5-O', 'mcg-O', '/-O', 'kg-O', 'per-O', 'min-O', ')-O', 'dobutamine-B-Chemical', '.-O']
['This-O', 'report-O', 'of-O', 'torsade-B-Disease', 'de-I-Disease', 'pointes-I-Disease', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'during-O', 'intermittent-O', 'dobutamine-B-Chemical', 'supports-O', 'the-O', 'hypothesis-O', 'that-O', 'unpredictable-O', 'fatal-O', 'arrhythmias-B-Disease', 'may-O', 'occur-O', 'even-O', 'with-O', 'low-O', 'doses-O', 'and-O', 'in-O', 'patients-O', 'with-O', 'no-O', 'history-O', 'of-O', 'significant-O', 'rhythm-O', 'disturbances-O', '.-O']
['The-O', 'mechanisms-O', 'of-O', 'proarrhythmic-O', 'effects-O', 'of-O', 'Dobutamine-B-Chemical']
['Positive-O', 'skin-O', 'tests-O', 'in-O', 'late-O', 'reactions-O', 'to-O', 'radiographic-O', 'contrast-O', 'media-O', '.-O']
['In-O', 'the-O', 'last-O', 'few-O', 'years-O', 'delayed-O', 'reactions-O', 'several-O', 'hours-O', 'after-O', 'the-O', 'injection-O', 'of-O', 'radiographic-O', 'and-O', 'contrast-O', 'materials-O', '(-O', 'PRC-O', ')-O', 'have-O', 'been-O', 'described-O', 'with-O', 'increasing-O', 'frequency-O', '.-O']
['The-O', 'authors-O', 'report-O', 'two-O', 'observations-O', 'on-O', 'patients-O', 'with-O', 'delayed-B-Disease', 'reactions-O', 'in-O', 'whom-O', 'intradermoreactions-O', '(-O', 'IDR-O', ')', 'and-O', 'patch-O', 'tests-O', 'to-O', 'a-O', 'series-O', 'of-O', 'ionic-O', 'and-O', 'non-O', 'ionic-O', 'PRC-B-Chemical', 'were-O', 'studied-O', '.-O']
['After-O', 'angiography-O', 'by-O', 'the-O', 'venous-O', 'route-O', 'in-O', 'patient-O', 'n-O', 'degree-O', '1-O', 'a-O', 'biphasic-O', 'reaction-O', 'with-O', 'an-O', 'immediate-O', 'reaction-O', '(-O', 'dyspnea-B-Disease', ',', 'loss-O', 'of-O', 'consciousness-B-Disease', ')', 'and-O', 'delayed-O', 'macro-papular-O', 'rash-B-Disease', 'appeared-O', ',', 'whilst-O', 'patient-O', 'n-O', 'degree-O', '2-O', 'developed-O', 'a-O', 'generalised-O', 'sensation-O', 'of-O', 'heat-O', ',', 'persistent-O', 'pain-O', 'at-O', 'the-O', 'site-O', 'of-O', 'injection-O', 'immediately-O', 'and-O', 'a-O', 'generalised-O', 'macro-O', ',', 'papular-O', 'reaction-O', 'after-O', '24-O', 'hours-O', '.-O']
['The-O', 'skin-O', 'tests-O', 'revealed-O', 'positive-O', 'delayed-O', 'reactions-O', 'of-O', '24-O', 'hours-O', 'and-O', '48-O', 'hours-O', 'by-O', 'IDR-O', 'and-O', 'patch-O', 'tests-O', 'to-O', 'only-O', 'some-O', 'PRC-B-Chemical', 'with-O', 'common-O', 'chains-O', 'in-O', 'their-O', 'structures-O', '.-O']
['The-O', 'positive-O', 'skin-O', 'tests-O', 'are-O', 'in-O', 'favour-O', 'of-O', 'immunological-O', 'reactions-O', 'and-O', 'may-O', 'help-O', 'in-O', 'diagnosis-O', 'of-O', 'allergy-B-Disease']
['Risk-O', 'of-O', 'transient-O', 'hyperammonemic-B-Disease', 'encephalopathy-B-Disease', 'in-O', 'cancer-B-Disease', 'patients-O', 'who-O', 'received-O', 'continuous-O', 'infusion-O', 'of-O', '5-fluorouracil-B-Chemical', 'with-O', 'the-O', 'complication-O', 'of-O', 'dehydration-B-Disease', 'and-O', 'infection-B-Disease', '.-O']
['From-O', '1986-O', 'to-O', '1998-O', ',-O', '29-O', 'cancer-B-Disease', 'patients-O', 'who-O', 'had-O', '32-O', 'episodes-O', 'of-O', 'transient-O', 'hyperammonemic-B-Disease', 'encephalopathy-I-Disease', 'related-O', 'to-O', 'continuous-O', 'infusion-O', 'of-O', '5-fluorouracil-B-Chemical', '(-O', '5-FU-B-Chemical', ')-O', 'were-O', 'identified-O', '.-O']
['of-O', 'the-O', 'patients-O', 'had-O', 'decompensated-O', 'liver-B-Disease', 'disease-I-Disease', '.-O']
['Onset-O', 'of-O', 'hyperammonemic-B-Disease', 'encephalopathy-B-Disease', 'varied-O', 'from-O', '0-O', '.-O']
['5-O', 'to-O', '5-O', 'days-O', '(-O', 'mean-O', ':-O', '2-O', '.-O']
['6-O', '+-O', '1-O', '.-O']
['3-O', 'days-O', ')-O', 'after-O', 'the-O', 'initiation-O', 'of-O', 'chemotherapy-O', '.-O']
['Plasma-O', 'ammonium-B-Chemical', 'level-O', 'ranged-O', 'from-O', '248-O', 'to-O', '2387-O', 'microg-O', '(-O', 'mean-O', ':-O', '626-O', '+-O', '431-O', 'microg-O', ')-O', 'Among-O', 'the-O', '32-O', 'episodes-O', ',-O', '26-O', '(-O', '81-O', ')-O', 'had-O', 'various-O', 'degrees-O', 'of-O', 'azotemia-B-Disease', ',-O', '18-O', '(-O', '56-O', ')-O', 'occurred-O', 'during-O', 'bacterial-O', 'infections-O', 'and-O', '14-O', '(-O', '44-O', ')-O', 'without-O', 'infection-O', 'occurred-O', 'during-O', 'periods-O', 'of-O', 'dehydration-B-Disease', '.-O']
['Higher-O', 'plasma-O', 'ammonium-B-Chemical', 'levels-O', 'and-O', 'more-O', 'rapid-O', 'onset-O', 'of-O', 'hyperammonemia-B-Disease', 'were-O', 'seen-O', 'in-O', '18-O', 'patients-O', 'with-O', 'bacterial-B-Disease', 'infections-I-Disease', '(-O', 'p-O', '=-O', '0-O', ').-O']
['003-O', 'and-O', '0-O', '.-O']
['0006-O', ',-O', 'respectively-O', ')-O', 'and-O', 'in-O', 'nine-O', 'patients-O', 'receiving-O', 'high-O', 'daily-O', 'doses-O', '(-O', '2600-O', 'or-O', '1800-O', 'mg-O', '/-O', 'm2-O', ')-O', 'of-O', '5-FU-B-Chemical', '(-O', 'p-O', '=O', '0-O', '.-O']
['0001-O', 'and-O', '<-O', '0-O', '.-O']
['0001-O', ',-O', 'respectively-O', ')-O', '.', 'In-O', '25-O', 'out-O', 'of-O', '32-O', 'episodes-O', '(-O', '78-O', ')-O', ',', 'plasma-O', 'ammonium-B-Chemical', 'levels-O', 'and-O', 'mental-O', 'status-O', 'returned-O', 'to-O', 'normal-O', 'within-O', '2-O', 'days-O', 'after-O', 'adequate-O', 'management-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'hyperammonemic-O', 'encephalopathy-B-Disease', 'can-O', 'occur-O', 'in-O', 'patients-O', 'receiving-O', 'continuous-O', 'infusion-O', 'of-O', '5-FU-B-Chemical', '.-O']
['Azotemia-B-Disease', ',-O', 'body-O', 'fluid-O', 'insufficiency-I-Disease', 'and-O', 'bacterial-O', 'infections-B-Disease', 'were-O', 'frequently-O', 'found-O', 'in-O', 'these-O', 'patients-O', '.-O']
['It-O', 'is-O', 'therefore-O', 'important-O', 'to-O', 'recognize-O', 'this-O', 'condition-B-Disease', 'in-O', 'patients-O', 'receiving-O', 'continuous-O', 'infusion-O', 'of-O', '5-FU-B-Chemical']
['The-O', 'effects-O', 'of-O', 'quinine-B-Chemical', 'and-O', '4-aminopyridine-B-Chemical', 'on-O', 'conditioned-O', 'place-O', 'preference-O', 'and-O', 'changes-O', 'in-O', 'motor-O', 'activity-O', 'induced-O', 'by-O', 'morphine-B-Chemical', 'in-O', 'rats-O', '.-O']
['1-O', '.-O']
['The-O', 'effects-O', 'of-O', 'two-O', 'unselective-O', 'potassium-B-Chemical', '(-O', 'K-O', ',-O', ')', 'channel-O', 'blockers-O', ',-O', 'quinine-B-Chemical', '(-O', '12-O', '.-O']
['5-O', ',', '25-O', 'and-O', '50-O', 'mg-O', '/-O', 'kg-O', ')-O', 'and-O', '4-aminopyridine-B-Chemical', '(-O', '1-O', 'and-O', '2-O', 'mg-O', '/-O', 'kg-O', ')-O', 'on-O', 'conditioned-O', 'place-O', 'preference-O', 'and-O', 'biphasic-O', 'changes-O', 'in-O', 'motor-O', 'activity-O', 'induced-O', 'by-O', 'morphine-B-Chemical', '(-O', '10-O', 'mg-O', '/-O', 'kg-O', ')-O', 'were-O', 'tested-O', 'in-O', 'Wistar-O', 'rats-O', '.-O']
['Quinine-B-Chemical', 'is-O', 'known-O', 'to-O', 'block-O', 'voltage-O', '-,O', 'calcium-B-Chemical', ',', 'and-O', 'ATP-B-Chemical', ',', 'sensitive-O', 'K-O', ',-O', 'channels-O', 'while-O', '4-aminopyridine-B-Chemical', 'is-O', 'known-O', 'to-O', 'block-O', 'voltage-O', ',', 'sensitive-O', 'K-O', ',-O', 'channels-O', '.-O']
['2-O', '.-O']
['In-O', 'the-O', 'counterbalanced-O', 'method-O', ',-O', 'quinine-B-Chemical', 'attenuated-O', 'morphine-B-Chemical', ',-O', 'induced-O', 'place-O', 'preference-O', ',-O', 'whereas-O', '4-aminopyridine-B-Chemical', 'was-O', 'ineffective-O', '.-O']
['In-O', 'the-O', 'motor-O', 'activity-O', 'test-O', 'measured-O', 'with-O', 'an-O', 'Animex-O', ',-O', 'activity-O', 'meter-O', 'neither-O', 'of-O', 'the-O', 'K-O', ',-O', 'channel-O', 'blockers-O', 'affected-O', 'morphine-B-Chemical', ',-O', 'induced-O', 'hypoactivity-I-Disease', ',-O', 'but-O', 'both-O', 'K-O', ',-O', 'channel-O', 'blockers-O', 'prevented-O', 'morphine-B-Chemical', ',-O', 'induced-O', 'secondary-O', 'hyperactivity-I-Disease', '.-O']
['3-O', '.-O']
['These-O', 'results-O', 'suggest-O', 'the-O', 'involvement-O', 'of-O', 'quinine-B-Chemical', ',-O', 'sensitive-O', 'but-O', 'not-O', '4-aminopyridine-B-Chemical', ',-O', 'sensitive-O', 'K-O', ',-O', 'channels-O', 'in-O', 'morphine-B-Chemical', 'reward-O', '.-O']
['It-O', 'is-O', 'also-O', 'suggested-O', 'that-O', 'the-O', 'blockade-O', 'of-O', 'K-O', ',-O', 'channels-O', 'sensitive-O', 'to-O', 'these-O', 'blockers-O', 'is-O', 'not-O', 'sufficient-O', 'to-O', 'prevent-O', 'morphine-B-Chemical', ',-O', 'induced-O', 'hypoactivity-B-Disease', 'whereas-O', 'morphine-B-Chemical', ',-O', 'induced-O', 'hyperactivity-B-Disease', 'seems-O', 'to-O', 'be-O', 'connected-O', 'to-O', 'both-O', 'quinine-B-Chemical', ',-O', 'and-O', '4-aminopyridine-B-Chemical', ',-O', 'sensitive-O', 'K-O', ',-O']
['Nociceptin-B-Chemical', '/-O', 'orphanin-B-Chemical', 'FQ-B-Chemical', 'and-O', 'nocistatin-B-Chemical', 'on-O', 'learning-O', 'and-O', 'memory-O', 'impairment-B-Disease', 'induced-O', 'by-O', 'scopolamine-B-Chemical', 'in-O', 'mice-O', '.-O']
['1-O', '.-O']
['Nociceptin-B-Chemical', ',-O', 'also-O', 'known-O', 'as-O', 'orphanin-O', 'FQ-O', ',-O', 'is-O', 'an-O', 'endogenous-O', 'ligand-O', 'for-O', 'the-O', 'orphan-O', 'opioid-O', 'receptor-O', ',-O', 'like-O', 'receptor-O', '1-O', '(-O', 'ORL1-O', ')-O', 'and-O', 'involves-O', 'in-O', 'various-O', 'functions-O', 'in-O', 'the-O', 'central-O', 'nervous-O', 'system-O', '(-O', 'CNS-O', ')-O', '.-O', 'On-O', 'the-O', 'other-O', 'hand-O', ',-O', 'nocistatin-B-Chemical', 'is-O', 'recently-O', 'isolated-O', 'from-O', 'the-O', 'same-O', 'precursor-O', 'as-O', 'nociceptin-B-Chemical', 'and-O', 'blocks-O', 'nociceptin-B-Chemical', ',-O', 'induced-O', 'allodynia-B-Disease', 'and-O', 'hyperalgesia-B-Disease', '.-O']
['2-O', '.-O']
['Although-O', 'ORL1-O', 'receptors-O', 'which-O', 'display-O', 'a-O', 'high-O', 'degree-O', 'of-O', 'sequence-O', 'homology-O', 'with-O', 'classical-O', 'opioid-O', 'receptors-O', 'are-O', 'abundant-O', 'in-O', 'the-O', 'hippocampus-O', ',-O', 'little-O', 'is-O', 'known-O', 'regarding-O', 'their-O', 'role-O', 'in-O', 'learning-O', 'and-O', 'memory-O', '.-O']
['3-O', '.-O']
['The-O', 'present-O', 'study-O', 'was-O', 'designed-O', 'to-O', 'investigate-O', 'whether-O', 'nociceptin-B-Chemical', '/', 'orphanin-B-Chemical', 'FQ-B-Chemical', 'and-O', 'nocistatin-B-Chemical', 'could-O', 'modulate-O', 'impairment-O', 'of-O', 'learning-O', 'and-O', 'memory-O', 'induced-O', 'by-O', 'scopolamine-B-Chemical', ',-O', 'a-O', 'muscarinic-O', 'cholinergic-O', 'receptor-O', 'antagonist-O', ',-O', 'using-O', 'spontaneous-O', 'alternation-O', 'of-O', 'Y-O', ',', 'maze-O', 'and-O', 'step-O', ',', 'down-O', 'type-O', 'passive-O', 'avoidance-O', 'tasks-O', 'in-O', 'mice-O', '.-O']
['4-O', '.-O']
['While-O', 'nocistatin-B-Chemical', '(-O', '0-O', '.-O']
['5-O', ',-O', '5-O', '.-O']
['0-O', 'nmol-O', 'mouse-O', ',-O', '1-O', ',-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ')-O', 'administered-O', '30-O', 'min-O', 'before-O', 'spontaneous-O', 'alternation-O', 'performance-O', 'or-O', 'the-O', 'training-O', 'session-O', 'of-O', 'the-O', 'passive-O', 'avoidance-O', 'task-O', ',-O', 'had-O', 'no-O', 'effect-O', 'on-O', 'spontaneous-O', 'alternation-O', 'or-O', 'passive-O', 'avoidance-O', 'behaviours-O', ',-O', 'a-O', 'lower-O', 'per-O', 'cent-O', 'alternation-O', 'and-O', 'shorter-O', 'median-O', 'step-O', ',-O', 'down-O', 'latency-O', 'in-O', 'the-O', 'retention-O', 'test-O', 'were-O', 'obtained-O', 'in-O', 'nociceptin-B-Chemical', '(-O', '1-O', '.-O']
['5-O', 'and-O', '/-O', 'or-O', '5-O', '.-O']
['0-O', 'nmol-O', 'mouse-O', ',-O', '1-O', ',-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ')-O', 'treated-O', 'normal-O', 'mice-O', '.-O']
['5-O', '.-O']
['Administration-O', 'of-O', 'nocistatin-B-Chemical', '(-O', '1-O', '.-O']
['5-O', 'and-O', '/-O', 'or-O', '5-O', '.-O']
['0-O', 'nmol-O', 'mouse-O', ',-O', '1-O', ',-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ')-O', '30-O', 'min-O', 'before-O', 'spontaneous-O', 'alternation-O', 'performance-O', 'or-O', 'the-O', 'training-O', 'session-O', 'of-O', 'the-O', 'passive-O', 'avoidance-O', 'task-O', ',-O', 'attenuated-O', 'the-O', 'scopolamine-B-Chemical', ',-O', 'induced-O', 'impairment-B-Disease', 'of-O', 'spontaneous-O', 'alternation-O', 'and-O', 'passive-O', 'avoidance-O', 'behaviours-O', '.-O']
['6-O', '.-O']
['These-O', 'results-O', 'indicated-O', 'that-O', 'nocistatin-B-Chemical', ',-O', 'a-O', 'new-O', 'biologically-O', 'active-O', 'peptide-O', ',-O', 'ameliorates-O', 'impairments-O', 'of-O', 'spontaneous-O', 'alternation-O', 'and-O', 'passive-O', 'avoidance-O', 'induced-O', 'by-O', 'scopolamine-B-Chemical']
['Meloxicam-B-Chemical', ',-O', 'induced-O', 'liver-B-Disease', 'toxicity-I-Disease', '.-O']
['We-O', 'report-O', 'the-O', 'case-O', 'of-O', 'a-O', 'female-O', 'patient-O', 'with-O', 'rheumatoid-B-Disease', 'arthritis-I-Disease', 'who-O', 'developed-O', 'acute-O', 'cytolytic-O', 'hepatitis-B-Disease', 'due-O', 'to-O', 'meloxicam-B-Chemical', '.-O']
['Recently-O', 'introduced-O', 'in-O', 'Belgium-O', ',-O', 'meloxicam-B-Chemical', 'is-O', 'the-O', 'first-O', 'nonsteroidal-O', 'antiinflammatory-O', 'drug-O', 'with-O', 'selective-O', 'action-O', 'on-O', 'the-O', 'inducible-O', 'form-O', 'of-O', 'cyclooxygenase-O', '2-O', '.-O']
['The-O', 'acute-O', 'cytolytic-O', 'hepatitis-B-Disease', 'occurred-O', 'rapidly-O', 'after-O', 'meloxicam-B-Chemical', 'administration-O', 'and-O', 'was-O', 'associated-O', 'with-O', 'the-O', 'development-O', 'of-O', 'antinuclear-O', 'antibodies-O', 'suggesting-O', 'a-O', 'hypersensitivity-O', 'mechanism-O', '.-O']
['This-O', 'first-O', 'case-O', 'of-O', 'meloxicam-B-Chemical', 'related-O', 'liver-B-Disease', 'toxicity-O', 'demonstrates-O', 'the-O', 'potential-O', 'of-O', 'this-O', 'drug-O', 'to-O', 'induce-O', 'hepatic-B-Disease', 'damage-O']
['Induction-O', 'of-O', 'apoptosis-O', 'by-O', 'remoxipride-B-Chemical', 'metabolites-O', 'in-O', 'HL60-O', 'and-O', 'CD34-O', '+/-O', 'CD19-O', ',', 'human-O', 'bone-B-Disease', 'marrow-I-Disease', 'progenitor-O', 'cells-O', ':-O', 'potential-O', 'relevance-O', 'to-O', 'remoxipride-B-Chemical', ',-O', 'induced-O', 'aplastic-B-Disease', 'anemia-I-Disease', '.-O']
['The-O', 'antipsychotic-O', 'agent-O', ',-O', 'remoxipride-B-Chemical', '[O', '(S)-(-)-3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxybenz-O', 'amide-O', ']-O', 'has-O', 'been-O', 'associated-O', 'with-O', 'acquired-O', 'aplastic-B-Disease', 'anemia-I-Disease', '.-O']
['We-O', 'have-O', 'examined-O', 'the-O', 'ability-O', 'of-O', 'remoxipride-B-Chemical', ',-O', 'three-O', 'pyrrolidine-O', 'ring-O', 'metabolites-O', 'and-O', 'five-O', 'aromatic-O', 'ring-O', 'metabolites-O', 'of-O', 'the-O', 'parent-O', 'compound-O', 'to-O', 'induce-O', 'apoptosis-B-Disease', 'in-O', 'HL60-O', 'cells-O', 'and-O', 'human-O', 'bone-O', 'marrow-O', 'progenitor-O', '(-O', 'HBMP-O', ')-O', 'cells-O', '.-O']
['Cells-O', 'were-O', 'treated-O', 'for-O', '0-O', ',-O', '24-O', 'h-O', 'with-O', 'each-O', 'compound-O', '(-O', '0-O', ',-O', '200-O', 'microM-O', ')-O', '.-O', 'Apoptosis-O', 'was-O', 'assessed-O', 'by-O', 'fluorescence-O', 'microscopy-O', 'in-O', 'Hoechst-O', '33342-B-Chemical', ',-O', 'and-O', 'propidium-O', 'iodide-B-Chemical', 'stained-O', 'cell-O', 'samples-O', '.-O']
['Results-O', 'were-O', 'confirmed-O', 'by-O', 'determination-O', 'of-O', 'internucleosomal-O', 'DNA-O', 'fragmentation-O', 'using-O', 'gel-O', 'electrophoresis-O', 'for-O', 'HL60-O', 'cell-O', 'samples-O', 'and-O', 'terminal-O', 'deoxynucleotidyl-O', 'transferase-O', 'assay-O', 'in-O', 'HBMP-O', 'cells-O', '.-O']
['The-O', 'catechol-B-Chemical', 'and-O', 'hydroquinone-B-Chemical', 'metabolites-O', ',-O', 'NCQ436-B-Chemical', 'and-O', 'NCQ344-B-Chemical', ',-O', 'induced-O', 'apoptosis-B-Disease', 'in-O', 'HL60-O', 'and-O', 'HBMP-O', 'cells-O', 'in-O', 'a-O', 'time-O', ',-O', 'and-O', 'concentration-O', 'dependent-O', 'manner-O', ',-O', 'while-O', 'the-O', 'phenols-O', ',-O', 'NCR181-B-Chemical', ',-O', 'FLA873-B-Chemical', ',-O', 'and-O', 'FLA797-B-Chemical', ',-O', 'and-O', 'the-O', 'derivatives-O', 'formed-O', 'by-O', 'oxidation-O', 'of-O', 'the-O', 'pyrrolidine-O', 'ring-O', ',-O', 'FLA838-B-Chemical', ',-O', 'NCM001-B-Chemical', ',-O', 'and-O', 'NCL118-B-Chemical', ',-O', 'had-O', 'no-O', 'effect-O', '.-O']
['No-O', 'necrosis-B-Disease', 'was-O', 'observed-O', 'in-O', 'cells-O', 'treated-O', 'with-O', 'NCQ436-B-Chemical', 'but-O', 'NCQ344-B-Chemical', 'had-O', 'a-O', 'biphasic-O', 'effect-O', 'in-O', 'both-O', 'cell-O', 'types-O', ',-O', 'inducing-O', 'apoptosis-B-Disease', 'at-O', 'lower-O', 'concentrations-O', 'and-O', 'necrosis-B-Disease', 'at-O', 'higher-O', 'concentrations-O', '.-O']
['These-O', 'data-O', 'show-O', 'that-O', 'the-O', 'catechol-B-Chemical', 'and-O', 'hydroquinone-B-Chemical', 'metabolites-O', 'of-O', 'remoxipride-B-Chemical', 'have-O', 'direct-O', 'toxic-O', 'effects-O', 'in-O', 'HL60-O', 'and-O', 'HBMP-O', 'cells-O', ',-O', 'leading-O', 'to-O', 'apoptosis-B-Disease', ',-O', 'while-O', 'the-O', 'phenol-B-Chemical', 'metabolites-O', 'were-O', 'inactive-O', '.-O']
['Similarly-O', ',-O', 'benzene-B-Chemical', ',-O', 'derived-O', 'catechol-B-Chemical', 'and-O', 'hydroquinone-B-Chemical', ',-O', 'but-O', 'not-O', 'phenol-B-Chemical', ',-O', 'induce-O', 'apoptosis-B-Disease', 'in-O', 'HBMP-O', 'cells-O', '[', 'Moran-O', 'et-O', 'al-O', '.-O', 'Mol-O', '.-O']
['Pharmacol-O', '.,-O', '50-O', '(-O', '1996-O', ')-O', '610-O', ',-O', '615-O', '].-O', 'We-O', 'propose-O', 'that-O', 'remoxipride-B-Chemical', 'and-O', 'benzene-B-Chemical', 'may-O', 'induce-O', 'aplastic-B-Disease', 'anemia-I-Disease', 'via-O', 'production-O', 'of-O', 'similar-O', 'reactive-O', 'metabolites-O', 'and-O', 'that-O', 'the-O', 'ability-O', 'of-O', 'NCQ436-B-Chemical', 'and-O', 'NCQ344-B-Chemical', 'to-O', 'induce-O', 'apoptosis-O', 'in-O', 'HBMP-O', 'cells-O', 'may-O', 'contribute-O', 'to-O', 'the-O', 'mechanism-O', 'underlying-O', 'acquired-O', 'aplastic-B-Disease', 'anemia-I-Disease', 'that-O', 'has-O', 'been-O', 'associated-O', 'with-O', 'remoxipride-B-Chemical']
['Synthesis-O', 'and-O', 'preliminary-O', 'pharmacological-O', 'investigations-O', 'of-O', '1-(1,2-dihydro-2-acenaphthylenyl)piperazine-B-Chemical', 'derivatives-O', 'as-O', 'potential-O', 'atypical-O', 'antipsychotic-O', 'agents-O', 'in-O', 'mice-O', '.-O']
['In-O', 'research-O', 'towards-O', 'the-O', 'development-O', 'of-O', 'new-O', 'atypical-O', 'antipsychotic-O', 'agents-O', ',-O', 'one-O', 'strategy-O', 'is-O', 'that-O', 'the-O', 'dopaminergic-O', 'system-O', 'can-O', 'be-O', 'modulated-O', 'through-O', 'manipulation-O', 'of-O', 'the-O', 'serotonergic-O', 'system-O', '.-O']
['The-O', 'synthesis-O', 'and-O', 'preliminary-O', 'pharmacological-O', 'evaluation-O', 'of-O', 'a-O', 'series-O', 'of-O', 'potential-O', 'atypical-O', 'antipsychotic-O', 'agents-O', 'based-O', 'on-O', 'the-O', 'structure-O', 'of-O', '1-(1,2-dihydro-2-acenaphthylenyl)piperazine-B-Chemical', '(-O', '7-O', ')-O', 'is-O', 'described-O', '.-O']
['Compound-O', '7e-O', ',-O', '5-{2-[4-(1,2-dihydro-2-acenaphthylenyl)piperazinyl]ethyl}-2,3-dihy-O', 'dro-1H-O', 'indol-2-one-O', ',-O', 'from-O', 'this-O', 'series-O', 'showed-O', 'significant-O', 'affinities-O', 'at-O', 'the-O', '5-O', ',', 'HT1A-O', 'and-O', '5-O', ',', 'HT2A-O', 'receptors-O', 'and-O', 'moderate-O', 'affinity-O', 'at-O', 'the-O', 'D2-O', 'receptor-O', '.-O']
['7e-O', 'exhibits-O', 'a-O', 'high-O', 'reversal-O', 'of-O', 'catalepsy-B-Disease', 'induced-O', 'by-O', 'haloperidol-B-Chemical']
['Sub-O', ',-O', 'chronic-O', 'inhibition-O', 'of-O', 'nitric-oxide-B-Chemical', 'synthesis-O', 'modifies-O', 'haloperidol-B-Chemical', ',-O', 'induced-O', 'catalepsy-B-Disease', 'and-O', 'the-O', 'number-O', 'of-O', 'NADPH-B-Chemical', ',-O', 'diaphorase-O', 'neurons-O', 'in-O', 'mice-O', '.-O']
['RATIONALE-O', ':-O', 'NG-nitro-L-arginine-B-Chemical', '(-O', 'L-NOARG-B-Chemical', ')-O', 'an-O', 'inhibitor-O', 'of-O', 'nitric-oxide-B-Chemical', 'synthase-O', '(-O', 'NOS-B-Chemical', ')-O', 'induces-O', 'catalepsy-B-Disease', 'in-O', 'mice-O', '.-O']
['This-O', 'effect-O', 'undergoes-O', 'rapid-O', 'tolerance-O', ',-O', 'showing-O', 'a-O', 'significant-O', 'decrease-O', 'after-O', '2-O', 'days-O', 'of-O', 'sub-O', '--O', 'chronic-O', 'L-NOARG-B-Chemical', 'treatment-O', '.-O']
['Nitric-B-Chemical', 'oxide-I-Chemical', '(-O', 'NO-B-Chemical', ')-O', 'has-O', 'been-O', 'shown-O', 'to-O', 'influence-O', 'dopaminergic-O', 'neurotransmission-O', 'in-O', 'the-O', 'striatum-O', '.-O']
['Neuroleptic-O', 'drugs-O', 'such-O', 'as-O', 'haloperidol-B-Chemical', ',-O', 'which-O', 'block-O', 'dopamine-B-Chemical', 'receptors-O', ',-O', 'also-O', 'cause-O', 'catalepsy-B-Disease', 'in-O', 'rodents-O', '.-O']
['OBJECTIVES-O', ':-O', 'To-O', 'investigate-O', 'the-O', 'effects-O', 'of-O', 'subchronic-O', 'L-NOARG-B-Chemical', 'treatment-O', 'in-O', 'haloperidol-B-Chemical', ',-O', 'induced-O', 'catalepsy-B-Disease', 'and-O', 'the-O', 'number-O', 'of-O', 'NOS-B-Chemical', 'neurons-O', 'in-O', 'areas-O', 'related-O', 'to-O', 'motor-O', 'control-O', '.-O']
['METHODS-O', ':-O', 'Male-O', 'albino-O', 'Swiss-O', 'mice-O', 'were-O', 'treated-O', 'sub-O', ',', 'chronically-O', '(-O', 'twice-O', 'a-O', 'day-O', 'for-O', '4-O', 'days-O', ')-O', 'with-O', 'L-NOARG-B-Chemical', '(-O', '40-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', ')-O', 'or-O', 'haloperidol-B-Chemical', '(-O', '1-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', ').-O', 'Catalepsy-B-Disease', 'was-O', 'evaluated-O', 'at-O', 'the-O', 'beginning-O', 'and-O', 'the-O', 'end-O', 'of-O', 'the-O', 'treatments-O', '.-O']
['Reduced-O', 'nicotinamide-B-Chemical', 'adenine-B-Chemical', 'dinucleotide-B-Chemical', 'phosphate-B-Chemical', ',-O', 'diaphorase-O', '(-O', 'NADPH-B-Chemical', ',-O', 'd-O', ')-O', 'histochemistry-O', 'was-O', 'also-O', 'employed-O', 'to-O', 'visualize-O', 'NOS-B-Chemical', 'as-O', 'an-O', 'index-O', 'of-O', 'enzyme-O', 'expression-O', 'in-O', 'mice-O', 'brain-O', 'regions-O', 'related-O', 'to-O', 'motor-O', 'control-O', '.-O']
['RESULTS-O', ':-O', 'L-NOARG-O', 'sub-O', ',-O', 'chronic-O', 'administration-O', 'produced-O', 'tolerance-O', 'of-O', 'L-NOARG-O', 'and-O', 'of-O', 'haloperidol-B-Chemical', ',-O', 'induced-O', 'catalepsy-B-Disease', '.-O']
['It-O', 'also-O', 'induced-O', 'an-O', 'increase-O', 'in-O', 'the-O', 'number-O', 'of-O', 'NADPH-B-Chemical', ',-O', 'd-O', ',-O', 'positive-O', 'cells-O', 'in-O', 'the-O', 'dorsal-O', 'part-O', 'of-O', 'the-O', 'caudate-O', 'and-O', 'accumbens-O', 'nuclei-O', 'compared-O', 'with-O', 'haloperidol-B-Chemical', 'and-O', 'in-O', 'the-O', 'pedunculopontine-O', 'tegmental-O', 'nucleus-O', 'compared-O', 'with-O', 'saline-O', '.-O']
['In-O', 'contrast-O', ',-O', 'there-O', 'was-O', 'a-O', 'decrease-O', 'in-O', 'NADPH-B-Chemical', ',-O', 'd-O', 'neuron-O', 'number-O', 'in-O', 'the-O', 'substantia-O', 'nigra-O', ',-O', 'pars-O', 'compacta-O', 'in-O', 'both-O', 'haloperidol-B-Chemical', ',-O', 'treated-O', 'and-O', 'L-NOARG-B-Chemical', ',-O', 'treated-O', 'animals-O', '.-O']
['CONCLUSIONS-O', ':-O', 'The-O', 'results-O', 'give-O', 'further-O', 'support-O', 'to-O', 'the-O', 'hypothesis-O', 'that-O', 'NO-B-Chemical']
['Prolonged-O', 'left-O', 'ventricular-O', 'dysfunction-I-Disease', 'occurs-O', 'in-O', 'patients-O', 'with-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease', 'after-O', 'both-O', 'dobutamine-B-Chemical', 'and-O', 'exercise-O', 'induced-O', 'myocardial-B-Disease', 'ischaemia-I-Disease', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'determine-O', 'whether-O', 'pharmacological-O', 'stress-O', 'leads-O', 'to-O', 'prolonged-O', 'but-O', 'reversible-O', 'left-O', 'ventricular-O', 'dysfunction-B-Disease', 'in-O', 'patients-O', 'with-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease', ',-O', 'similar-O', 'to-O', 'that-O', 'seen-O', 'after-O', 'exercise-O', '.-O']
['DESIGN-O', ':-O', 'A-O', 'randomised-O', 'crossover-O', 'study-O', 'of-O', 'recovery-O', 'time-O', 'of-O', 'systolic-O', 'and-O', 'diastolic-O', 'left-O', 'ventricular-O', 'function-O', 'after-O', 'exercise-O', 'and-O', 'dobutamine-B-Chemical', 'induced-O', 'ischaemia-B-Disease', '.-O']
['SUBJECTS-O', ':-O', '10-O', 'patients-O', 'with-O', 'stable-O', 'angina-B-Disease', ',-O', 'angiographically-O', 'proven-O', 'coronary-B-Disease', 'artery-O', 'disease-I-Disease', ',-O', 'and-O', 'normal-O', 'left-O', 'ventricular-O', 'function-O', '.-O']
['INTERVENTIONS-O', ':-O', 'Treadmill-O', 'exercise-O', 'and-O', 'dobutamine-B-Chemical', 'stress-O', 'were-O', 'performed-O', 'on-O', 'different-O', 'days-O', '.-O']
['Quantitative-O', 'assessment-O', 'of-O', 'systolic-O', 'and-O', 'diastolic-O', 'left-O', 'ventricular-O', 'function-O', 'was-O', 'performed-O', 'using-O', 'transthoracic-O', 'echocardiography-O', 'at-O', 'baseline-O', 'and-O', 'at-O', 'regular-O', 'intervals-O', 'after-O', 'each-O', 'test-O', '.-O']
['RESULTS-O', ':-O', 'Both-O', 'forms-O', 'of-O', 'stress-O', 'led-O', 'to-O', 'prolonged-O', 'but-O', 'reversible-O', 'systolic-B-Disease', 'and-O', 'diastolic-B-Disease', 'dysfunction-I-Disease', '.-O']
['There-O', 'was-O', 'no-O', 'difference-O', 'in-O', 'the-O', 'maximum-O', 'double-O', 'product-O', '(-O', 'p-O', '=-O', '0-O', '.-O']
['53-O', ')-O', 'or-O', 'ST-O', 'depression-B-Disease', '(-O', 'p-O', '=-O', '0-O', '.-O']
['63-O', ')-O', 'with-O', 'either-O', 'form-O', 'of-O', 'stress-O', '.-O']
['After-O', 'exercise-O', ',-O', 'ejection-O', 'fraction-O', 'was-O', 'reduced-O', 'at-O', '15-O', 'and-O', '30-O', 'minutes-O', 'compared-O', 'with-O', 'baseline-O', '(-O', 'mean-O', '(-O', 'SEM-O', ')-O', '-', '5-O', '.-O']
['6-O', '(-O', '1-O', '.-O']
['5-O', ')-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ';-O', 'and-O', ',-O', '6-O', '.-O']
['1-O', '(-O', '2-O', '.-O']
['2-O', ')-O', ',-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', '),-O', 'and-O', 'at-O', '30-O', 'and-O', '45-O', 'minutes-O', 'after-O', 'dobutamine-B-Chemical', '(-O', '10-O', '.-O']
['8-O', '(-O', '1-O', '.-O']
['8-O', ')%-O', 'and-O', ',-O', '5-O', '.-O']
['5-O', '(-O', '1-O', '.-O']
['8-O', ')-O', 'both-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'Regional-O', 'analysis-O', 'showed-O', 'a-O', 'reduction-O', 'in-O', 'the-O', 'worst-O', 'affected-O', 'segment-O', '15-O', 'and-O', '30-O', 'minutes-O', 'after-O', 'exercise-O', '(-O', '27-O', '.-O']
['9-O', '(-O', '7-O', '.-O']
['2-O', ')%-O', 'and-O', ',-O', '28-O', '.-O']
['6-O', '(-O', '5-O', '.-O']
['7-O', ')-O', 'both-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'and-O', 'at-O', '30-O', 'minutes-O', 'after-O', 'dobutamine-B-Chemical', '(-O', '32-O', '(-O', '5-O', '.-O']
['3-O', ')-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'The-O', 'isovolumic-O', 'relaxation-O', 'period-O', 'was-O', 'prolonged-O', '45-O', 'minutes-O', 'after-O', 'each-O', 'form-O', 'of-O', 'stress-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'CONCLUSIONS-O', ':-O', 'In-O', 'patients-O', 'with-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease', ',-O', 'dobutamine-B-Chemical', 'induced-O', 'ischaemia-I-Disease', 'results-O', 'in-O', 'prolonged-O', 'reversible-O', 'left-O', 'ventricular-O', 'dysfunction-I-Disease', ',-O', 'presumed-O', 'to-O', 'be-O', 'myocardial-B-Disease', 'stunning-I-Disease', ',-O', 'similar-O', 'to-O', 'that-O', 'seen-O', 'after-O', 'exercise-O', '.-O']
['Dobutamine-B-Chemical', 'induced-O', 'ischaemia-I-Disease', 'could-O', 'therefore-O', 'be-O', 'used-O', 'to-O', 'study-O', 'the-O', 'pathophysiology-O', 'of-O', 'this-O', 'phenomenon-O', 'further-O', 'in-O', 'patients-O', 'with-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease']
['Anorexigens-B-Chemical', 'and-O', 'pulmonary-O', 'hypertension-B-Disease', 'in-O', 'the-O', 'United-O', 'States-O', ':-O', 'results-O', 'from-O', 'the-O', 'surveillance-O', 'of-O', 'North-O', 'American-O', 'pulmonary-O', 'hypertension-B-Disease', '.-O']
['BACKGROUND-O', ':-O', 'The-O', 'use-O', 'of-O', 'appetite-B-Chemical', 'suppressants-I-Chemical', 'in-O', 'Europe-O', 'has-O', 'been-O', 'associated-O', 'with-O', 'the-O', 'development-O', 'of-O', 'primary-B-Disease', 'pulmonary-I-Disease', 'hypertension-I-Disease', '(-O', 'PPH-B-Disease', ')-O', '.', 'Recently-O', ',-O', 'fenfluramine-B-Chemical', 'appetite-B-Chemical', 'suppressants-I-Chemical', 'became-O', 'widely-O', 'used-O', 'in-O', 'the-O', 'United-O', 'States-O', 'but-O', 'were-O', 'withdrawn-O', 'in-O', 'September-O', '1997-O', 'because-O', 'of-O', 'concerns-O', 'over-O', 'adverse-O', 'effects-O', '.-O']
['MATERIALS-O', 'AND-O', 'METHODS-O', ':-O', 'We-O', 'conducted-O', 'a-O', 'prospective-O', 'surveillance-O', 'study-O', 'on-O', 'patients-O', 'diagnosed-O', 'with-O', 'pulmonary-B-Disease', 'hypertension-I-Disease', 'at-O', '12-O', 'large-O', 'referral-O', 'centers-O', 'in-O', 'North-O', 'America-O', '.-O']
['Data-O', 'collected-O', 'on-O', 'patients-O', 'seen-O', 'from-O', 'September-O', '1-O', ',-O', '1996-O', ',-O', 'to-O', 'December-O', '31-O', ',-O', '1997-O', ',-O', 'included-O', 'the-O', 'cause-O', 'of-O', 'the-O', 'pulmonary-B-Disease', 'hypertension-I-Disease', 'and-O', 'its-O', 'severity-O', '.-O']
['Patients-O', 'with-O', 'no-O', 'identifiable-O', 'cause-O', 'of-O', 'pulmonary-B-Disease', 'hypertension-I-Disease', 'were-O', 'classed-O', 'as-O', 'PPH-B-Disease', '.-O']
['A-O', 'history-O', 'of-O', 'drug-O', 'exposure-O', 'also-O', 'was-O', 'taken-O', 'with-O', 'special-O', 'attention-O', 'on-O', 'the-O', 'use-O', 'of-O', 'antidepressants-B-Chemical', ',-O', 'anorexigens-B-Chemical', ',-O', 'and-O', 'amphetamines-B-Chemical', '.-O']
['RESULTS-O', ':-O', 'Five-O', 'hundred-O', 'seventy-O', ',-O', 'nine-O', 'patients-O', 'were-O', 'studied-O', ',-O', '205-O', 'with-O', 'PPH-B-Disease', 'and-O', '374-O', 'with-O', 'pulmonary-B-Disease', 'hypertension-I-Disease', 'from-O', 'other-O', 'causes-O', '(-O', 'secondary-O', 'pulmonary-B-Disease', 'hypertension-I-Disease', '[', 'SPH-O', ']).-O', 'The-O', 'use-O', 'of-O', 'anorexigens-B-Chemical', 'was-O', 'common-O', 'in-O', 'both-O', 'groups-O', '.-O']
['However-O', ',-O', 'of-O', 'the-O', 'medications-O', 'surveyed-O', ',-O', 'only-O', 'the-O', 'fenfluramines-B-Chemical', 'had-O', 'a-O', 'significant-O', 'preferential-O', 'association-O', 'with-O', 'PPH-B-Disease', 'as-O', 'compared-O', 'with-O', 'SPH-B-Disease', '(-O', 'adjusted-O', 'odds-O', 'ratio-O', 'for-O', 'use-O', '>-O', '6-O', 'months-O', ',-O', '7-O', '.-O']
['5-O', ';-O', '95-O', '%-O', 'confidence-O', 'interval-O', ',-O', '1-O', '.-O']
['7-O', 'to-O', '32-O', '.-O']
['4-O', ').-O', 'The-O', 'association-O', 'was-O', 'stronger-O', 'with-O', 'longer-O', 'duration-O', 'of-O', 'use-O', 'when-O', 'compared-O', 'to-O', 'shorter-O', 'duration-O', 'of-O', 'use-O', 'and-O', 'was-O', 'more-O', 'pronounced-O', 'in-O', 'recent-O', 'users-O', 'than-O', 'in-O', 'remote-O', 'users-O', '.-O']
['An-O', 'unexpectedly-O', 'high-O', '(-O', '11-O', '.-O']
['4-O', ')-O', 'number-O', 'of-O', 'patients-O', 'with-O', 'SPH-B-Disease', 'had-O', 'used-O', 'anorexigens-B-Chemical', '.-O']
['CONCLUSION-O', ':-O', 'The-O', 'magnitude-O', 'of-O', 'the-O', 'association-O', 'with-O', 'PPH-B-Disease', ',-O', 'the-O', 'increase-O', 'of-O', 'association-O', 'with-O', 'increasing-O', 'duration-O', 'of-O', 'use-O', ',-O', 'and-O', 'the-O', 'specificity-O', 'for-O', 'fenfluramines-B-Chemical', 'are-O', 'consistent-O', 'with-O', 'previous-O', 'studies-O', 'indicating-O', 'that-O', 'fenfluramines-B-Chemical', 'are-O', 'causally-O', 'related-O', 'to-O', 'PPH-B-Disease', '.-O']
['The-O', 'high-O', 'prevalence-O', 'of-O', 'anorexigen-B-Chemical', 'use-O', 'in-O', 'patients-O', 'with-O', 'SPH-B-Disease', 'also-O', 'raises-O', 'the-O', 'possibility-O', 'that-O', 'these-O', 'drugs-O', 'precipitate-O', 'pulmonary-B-Disease', 'hypertension-I-Disease']
['Clinical-O', 'aspects-O', 'of-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', 'and-O', 'thrombosis-B-Disease', 'and-O', 'other-O', 'side-O', 'effects-O', 'of-O', 'heparin-B-Chemical', 'therapy-O', '.-O']
['Heparin-B-Chemical', ',-O', 'first-O', 'used-O', 'to-O', 'prevent-O', 'the-O', 'clotting-O', 'of-O', 'blood-O', 'in-O', 'vitro-O', ',-O', 'has-O', 'been-O', 'clinically-O', 'used-O', 'to-O', 'treat-O', 'thrombosis-B-Disease', 'for-O', 'more-O', 'than-O', '50-O', 'years-O', '.-O']
['Although-O', 'several-O', 'new-O', 'anticoagulant-O', 'drugs-O', 'are-O', 'in-O', 'development-O', ',-O', 'heparin-B-Chemical', 'remains-O', 'the-O', 'anticoagulant-O', 'of-O', 'choice-O', 'to-O', 'treat-O', 'acute-O', 'thrombotic-B-Disease', 'episodes-O', '.-O']
['The-O', 'clinical-O', 'effects-O', 'of-O', 'heparin-B-Chemical', 'are-O', 'meritorious-O', ',-O', 'but-O', 'side-O', 'effects-O', 'do-O', 'exist-O', '.-O']
['Bleeding-B-Disease', 'is-O', 'the-O', 'primary-O', 'untoward-O', 'effect-O', 'of-O', 'heparin-B-Chemical', '.-O']
['Major-O', 'bleeding-B-Disease', 'is-O', 'of-O', 'primary-O', 'concern-O', 'in-O', 'patients-O', 'receiving-O', 'heparin-B-Chemical', 'therapy-O', '.-O']
['However-O', ',-O', 'additional-O', 'important-O', 'untoward-O', 'effects-O', 'of-O', 'heparin-B-Chemical', 'therapy-O', 'include-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', ',-O', 'heparin-B-Chemical', ',-O', 'associated-O', 'osteoporosis-B-Disease', ',-O', 'eosinophilia-B-Disease', ',-O', 'skin-O', 'reactions-O', ',-O', 'allergic-B-Disease', 'reactions-O', 'other-O', 'than-O', 'thrombocytopenia-B-Disease', ',-O', 'alopecia-B-Disease', ',-O', 'transaminasemia-B-Disease', ',-O', 'hyperkalemia-B-Disease', ',-O', 'hypoaldosteronism-B-Disease', ',-O', 'and-O', 'priapism-B-Disease', '.-O']
['These-O', 'side-O', 'effects-O', 'are-O', 'relatively-O', 'rare-O', 'in-O', 'a-O', 'given-O', 'individual-O', ',-O', 'but-O', 'given-O', 'the-O', 'extremely-O', 'widespread-O', 'use-O', 'of-O', 'heparin-B-Chemical', ',-O', 'some-O', 'are-O', 'quite-O', 'common-O', ',-O', 'particularly-O', 'HITT-B-Disease', 'and-O', 'osteoporosis-B-Disease', '.-O']
['Although-O', 'reasonable-O', 'incidences-O', 'of-O', 'many-O', 'of-O', 'these-O', 'side-O', 'effects-O', 'can-O', 'be-O', 'x-O', 'softly-O', 'x-O', 'deduced-O', 'from-O', 'current-O', 'reports-O', 'dealing-O', 'with-O', 'unfractionated-O', 'heparin-B-Chemical', ',-O', 'at-O', 'present-O', 'the-O', 'incidences-O', 'of-O', 'these-O', 'side-O', 'effects-O', 'with-O', 'newer-O', 'low-O', 'molecular-O', 'weight-O', 'heparins-B-Chemical']
['A-O', 'case-O', 'of-O', 'bilateral-O', 'optic-O', 'neuropathy-B-Disease', 'in-O', 'a-O', 'patient-O', 'on-O', 'tacrolimus-B-Chemical', '(-O', 'FK506-B-Chemical', ')-O', 'therapy-O', 'after-O', 'liver-O', 'transplantation-O', '.-O']
['PURPOSE-O', ':-O', 'To-O', 'report-O', 'a-O', 'case-O', 'of-O', 'bilateral-O', 'optic-O', 'neuropathy-I-Disease', 'in-O', 'a-O', 'patient-O', 'receiving-O', 'tacrolimus-B-Chemical', '(-O', 'FK-B-Chemical', '506-I-Chemical', ',-O', 'Prograf-O', ';-O', 'Fujisawa-O', 'USA-O', ',', 'Inc-O', ',', 'Deerfield-O', ',', 'Illinois-O', ')-O', 'for-O', 'immunosuppression-O', 'after-O', 'orthotropic-O', 'liver-O', 'transplantation-O', '.-O']
['METHOD-O', ':-O', 'Case-O', 'report-O', '.-O']
['In-O', 'a-O', '58-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'receiving-O', 'tacrolimus-B-Chemical', 'after-O', 'orthotropic-O', 'liver-O', 'transplantation-O', ',-O', 'serial-O', 'neuro-O', ',-O', 'ophthalmologic-O', 'examinations-O', 'and-O', 'laboratory-O', 'studies-O', 'were-O', 'performed-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'patient-O', 'had-O', 'episodic-O', 'deterioration-O', 'of-O', 'vision-O', 'in-O', 'both-O', 'eyes-O', ',-O', 'with-O', 'clinical-O', 'features-O', 'resembling-O', 'ischemic-B-Disease', 'optic-B-Disease', 'neuropathies-I-Disease', '.-O']
['Deterioration-O', 'of-O', 'vision-B-Disease', 'occurred-O', 'despite-O', 'discontinuation-O', 'of-O', 'the-O', 'tacrolimus-B-Chemical', '.-O']
['CONCLUSION-O', ':-O', 'Tacrolimus-B-Chemical', 'and-O', 'other-O', 'immunosuppressive-O', 'agents-O', 'may-O', 'be-O', 'associated-O', 'with-O', 'optic-O', 'nerve-O', 'toxicity-B-Disease']
['Hypercalcemia-B-Disease', ',-O', 'arrhythmia-B-Disease', ',-O', 'and-O', 'mood-O', 'stabilizers-O', '.-O']
['Recent-O', 'findings-O', 'in-O', 'a-O', 'bipolar-B-Disease', 'patient-O', 'receiving-O', 'maintenance-O', 'lithium-B-Chemical', 'therapy-O', 'who-O', 'developed-O', 'hypercalcemia-B-Disease', 'and-O', 'severe-O', 'bradyarrhythmia-B-Disease', 'prompted-O', 'the-O', 'authors-O', 'to-O', 'conduct-O', 'a-O', 'retrospective-O', 'study-O', 'of-O', 'bipolar-B-Disease', 'patients-O', 'with-O', 'lithium-B-Chemical', ',-O', 'associated-O', 'hypercalcemia-B-Disease', '.-O']
['A-O', 'printout-O', 'of-O', 'all-O', 'cases-O', 'of-O', 'hypercalcemia-B-Disease', 'that-O', 'presented-O', 'during-O', 'a-O', '1-O', ',-O', 'year-O', 'period-O', 'was-O', 'generated-O', '.-O']
['After-O', 'eliminating-O', 'spurious-O', 'hypercalcemias-O', 'or-O', 'those-O', 'associated-O', 'with-O', 'intravenous-O', 'fluids-O', ',-O', 'the-O', 'authors-O', 'identified-O', '18-O', 'non-O', ',-O', 'lithium-B-Chemical', ',-O', 'treated-O', 'patients-O', 'with-O', 'hypercalcemias-O', 'related-O', 'to-O', 'malignancies-O', 'and-O', 'other-O', 'medical-O', 'conditions-O', '(-O', 'group-O', 'A-O', ')-O', 'and-O', '12-O', 'patients-O', 'with-O', 'lithium-B-Chemical', ',-O', 'associated-O', 'hypercalcemia-O', '(-O', 'group-O', 'B-O', ')-O', '.-O', 'Patients-O', 'in-O', 'group-O', 'B-O', 'were-O', 'not-O', 'comparable-O', 'to-O', 'those-O', 'in-O', 'group-O', 'A-O', ',-O', 'as-O', 'the-O', 'latter-O', 'were-O', 'medically-O', 'compromised-O', 'and-O', 'were-O', 'receiving-O', 'multiple-O', 'pharmacotherapies-O', '.-O']
['Thus-O', ',-O', 'two-O', 'control-O', 'groups-O', 'were-O', 'generated-O', ':-O', 'group-O', 'C1-O', ',-O', 'which-O', 'included-O', 'age-O', ',-O', 'and-O', 'sex-O', ',-O', 'comparable-O', 'lithium-B-Chemical', ',-O', 'treated-O', 'bipolar-B-Disease', 'normocalcemic-O', 'patients-O', ',-O', 'and-O', 'group-O', 'C2-O', ',-O', 'which-O', 'included-O', 'bipolar-B-Disease', 'normocalcemic-O', 'patients-O', 'treated-O', 'with-O', 'anticonvulsant-B-Chemical', 'mood-O', 'stabilizers-O', '.-O']
['The-O', 'electrocardiographic-O', '(-O', 'ECG-O', ')-O', 'findings-O', 'for-O', 'patients-O', 'in-O', 'group-O', 'B-O', 'were-O', 'compared-O', 'with-O', 'those-O', 'of-O', 'patients-O', 'in-O', 'groups-O', 'C1-O', 'and-O', 'C2-O', '.-O']
['It-O', 'was-O', 'found-O', 'that-O', 'these-O', 'groups-O', 'did-O', 'not-O', 'differ-O', 'in-O', 'their-O', 'overall-O', 'frequency-O', 'of-O', 'ECG-O', 'abnormalities-O', ';-O', 'however-O', ',-O', 'there-O', 'were-O', 'significant-O', 'differences-O', 'in-O', 'the-O', 'frequency-O', 'of-O', 'conduction-O', 'defects-O', '.-O']
['Patients-O', 'with-O', 'hypercalcemia-B-Disease', 'resulting-O', 'from-O', 'medical-O', 'diseases-O', 'and-O', 'bipolar-B-Disease', 'patients-O', 'with-O', 'lithium-B-Chemical', ',-O', 'associated-O', 'hypercalcemia-B-Disease']
['Attenuation-O', 'of-O', 'nephrotoxicity-B-Disease', 'by-O', 'a-O', 'novel-O', 'lipid-O', 'nanosphere-O', '(-O', 'NS-O', ',', '718-O', ')', 'incorporating-O', 'amphotericin-B-Chemical', 'B-I-Chemical', '.-O']
['NS-O', ',-O', '718-O', ',-O', 'a-O', 'lipid-O', 'nanosphere-O', 'incorporating-O', 'amphotericin-B-Chemical', 'B-I-Chemical', ',-O', 'is-O', 'effective-O', 'against-O', 'pathogenic-O', 'fungi-O', 'and-O', 'has-O', 'low-O', 'toxicity-O', '.-O']
['We-O', 'compared-O', 'the-O', 'toxicity-O', 'of-O', 'NS-O', ',', '718-O', 'with-O', 'that-O', 'of-O', 'Fungizone-O', '(-O', 'amphotericin-B-Chemical', 'B-sodium-B-Chemical', 'deoxycholate-O', ';-O', 'D-AmB-B-Chemical', ')', 'in-O', 'vitro-O', 'using-O', 'renal-O', 'cell-O', 'cultures-O', 'and-O', 'in-O', 'vivo-O', 'by-O', 'biochemical-O', 'analysis-O', ',-O', 'histopathological-O', 'study-O', 'of-O', 'the-O', 'kidney-O', 'and-O', 'pharmacokinetic-O', 'study-O', 'of-O', 'amphotericin-B-Chemical', 'B-I-Chemical', 'following-O', 'intravenous-O', 'infusion-O', 'of-O', 'the-O', 'formulation-O', 'in-O', 'rats-O', '.-O']
['Incubation-O', 'with-O', 'NS-O', ',-O', '718-O', 'resulted-O', 'in-O', 'significantly-O', 'less-O', 'damage-O', 'of-O', 'cultured-O', 'human-O', 'renal-O', 'proximal-O', 'tubular-O', 'epithelial-O', 'cells-O', 'compared-O', 'with-O', 'D-AmB-B-Chemical', '.-O']
['Serum-O', 'blood-O', 'urea-B-Chemical', 'and-O', 'creatinine-B-Chemical', 'concentrations-O', 'increased-O', 'significantly-O', 'in-O', 'rats-O', 'given-O', 'an-O', 'iv-O', 'infusion-O', 'of-O', 'D-AmB-B-Chemical', '3-O', 'mg-O', '/-O', 'kg-O', 'but-O', 'not-O', 'in-O', 'those-O', 'given-O', 'the-O', 'same-O', 'dose-O', 'of-O', 'NS-O', ',-O', '718-O', '.-O']
['Histopathological-O', 'examination-O', 'of-O', 'the-O', 'kidney-O', 'showed-O', 'tubular-O', 'necrosis-B-Disease', 'in-O', 'D-AmB-B-Chemical', ',-O', 'treated-O', 'rats-O', 'but-O', 'no-O', 'change-O', 'in-O', 'NS-O', ',-O', '718-O', ',-O', 'treated-O', 'rats-O', '.-O']
['Amphotericin-B-Chemical', 'B-I-Chemical', 'concentrations-O', 'in-O', 'the-O', 'kidney-O', 'in-O', 'NS-O', ',-O', '718-O', ',-O', 'treated-O', 'rats-O', 'were-O', 'higher-O', 'than-O', 'those-O', 'in-O', 'D-AmB-B-Chemical', ',-O', 'treated-O', 'rats-O', '.-O']
['Our-O', 'in-O', 'vitro-O', 'and-O', 'in-O', 'vivo-O', 'results-O', 'suggest-O', 'that-O', 'incorporation-O', 'of-O', 'amphotericin-B-Chemical', 'B-I-Chemical', 'into-O', 'lipid-O', 'nanospheres-O', 'of-O', 'NS-O', ',', '718-O', 'attenuates-O', 'the-O', 'nephrotoxicity-B-Disease', 'of-O', 'amphotericin-B-Chemical', 'B-I-Chemical']
['Patterns-O', 'of-O', 'sulfadiazine-B-Chemical', 'acute-O', 'nephrotoxicity-B-Disease', '.-O']
['Sulfadiazine-B-Chemical', 'acute-O', 'nephrotoxicity-B-Disease', 'is-O', 'reviving-O', 'specially-O', 'because-O', 'of-O', 'its-O', 'use-O', 'in-O', 'toxoplasmosis-B-Disease', 'in-O', 'HIV-B-Disease', ',-O', 'positive-O', 'patients-O', '.-O']
['We-O', 'report-O', '4-O', 'cases-O', ',-O', 'one-O', 'of-O', 'them-O', 'in-O', 'a-O', 'previously-O', 'healthy-O', 'person-O', '.-O']
['Under-O', 'treatment-O', 'with-O', 'sulfadiazine-B-Chemical', 'they-O', 'developed-O', 'oliguria-B-Disease', ',-O', 'abdominal-O', 'pain-I-Disease', ',-O', 'renal-B-Disease', 'failure-I-Disease', 'and-O', 'showed-O', 'multiple-O', 'radiolucent-O', 'renal-O', 'calculi-I-Disease', 'in-O', 'echography-O', '.-O']
['All-O', 'patients-O', 'recovered-O', 'their-O', 'previous-O', 'normal-O', 'renal-O', 'function-O', 'after-O', 'adequate-O', 'hydration-O', 'and-O', 'alcalinization-O', '.-O']
['A-O', 'nephrostomy-O', 'tube-O', 'had-O', 'to-O', 'be-O', 'placed-O', 'in-O', 'one-O', 'of-O', 'the-O', 'patients-O', 'for-O', 'ureteral-O', 'lithiasis-B-Disease', 'in-O', 'a-O', 'single-O', 'functional-O', 'kidney-O', '.-O']
['of-O', 'them-O', 'needed-O', 'dialysis-O', 'or-O', 'a-O', 'renal-O', 'biopsy-O', 'because-O', 'of-O', 'a-O', 'typical-O', 'benign-O', 'course-O', '.-O']
['Treatment-O', 'with-O', 'sulfadiazine-B-Chemical']
['Downbeat-B-Disease', 'nystagmus-B-Disease', 'associated-O', 'with-O', 'intravenous-O', 'patient-O', ',-O', 'controlled-O', 'administration-O', 'of-O', 'morphine-B-Chemical', '.-O']
['IMPLICATIONS-O', ':-O', 'This-O', 'case-O', 'documents-O', 'a-O', 'patient-O', 'who-O', 'developed-O', 'dizziness-B-Disease', 'with-O', 'downbeating-O', 'nystagmus-B-Disease', 'while-O', 'receiving-O', 'a-O', 'relatively-O', 'large-O', 'dose-O', 'of-O', 'IV-O', 'patient-O', ',-O', 'controlled-O', 'analgesia-O', 'morphine-B-Chemical', '.-O']
['Although-O', 'there-O', 'have-O', 'been-O', 'case-O', 'reports-O', 'of-O', 'epidural-O', 'morphine-B-Chemical', 'with-O', 'these-O', 'symptoms-O', 'and-O', 'signs-O', ',-O', 'this-O', 'has-O', 'not-O', 'been-O', 'previously-O', 'documented-O', 'with-O', 'IV-O', 'or-O', 'patient-O', ',-O', 'controlled-O', 'analgesia-O', 'morphine-B-Chemical']
['Hemodynamic-O', 'and-O', 'antiadrenergic-O', 'effects-O', 'of-O', 'dronedarone-B-Chemical', 'and-O', 'amiodarone-B-Chemical', 'in-O', 'animals-O', 'with-O', 'a-O', 'healed-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['The-O', 'hemodynamic-O', 'and-O', 'antiadrenergic-O', 'effects-O', 'of-O', 'dronedarone-B-Chemical', ',-O', 'a-O', 'noniodinated-O', 'compound-O', 'structurally-O', 'related-O', 'to-O', 'amiodarone-B-Chemical', ',-O', 'were-O', 'compared-O', 'with-O', 'those-O', 'of-O', 'amiodarone-B-Chemical', 'after-O', 'prolonged-O', 'oral-O', 'administration-O', ',-O', 'both-O', 'at-O', 'rest-O', 'and-O', 'during-O', 'sympathetic-O', 'stimulation-O', 'in-O', 'conscious-O', 'dogs-O', 'with-O', 'a-O', 'healed-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['All-O', 'dogs-O', '(-O', 'n-O', '=-O', '6-O', ')-O', 'randomly-O', 'received-O', 'orally-O', 'dronedarone-B-Chemical', '(-O', '10-O', 'and-O', '30-O', 'mg-O', '/-O', 'kg-O', ')-O', 'amiodarone-B-Chemical', '(-O', '10-O', 'and-O', '30-O', 'mg-O', '/-O', 'kg-O', ')-O', 'and-O', 'placebo-O', 'twice-O', 'daily-O', 'for-O', '7-O', 'days-O', ',-O', 'with-O', 'a-O', '3-O', ',-O', 'week-O', 'washout-O', 'between-O', 'consecutive-O', 'treatments-O', '.-O']
['Heart-O', 'rate-O', '(-O', 'HR-O', ')-O', 'mean-O', 'arterial-O', 'pressure-O', '(-O', 'MBP-O', ')-O', 'positive-O', 'rate-O', 'of-O', 'increase-O', 'of-O', 'left-O', 'ventricular-O', 'pressure-O', '(+-O', 'LVdP-O', '/-O', 'dt-O', ')-O', 'echocardiographically-O', 'assessed-O', 'left-O', 'ventricular-O', 'ejection-O', 'fraction-O', '(-O', 'LVEF-O', ')-O', 'and-O', 'fractional-O', 'shortening-O', '(-O', 'FS-O', ')-O', 'as-O', 'well-O', 'as-O', 'chronotropic-O', 'response-O', 'to-O', 'isoproterenol-B-Chemical', 'and-O', 'exercise-O', ',-O', 'induced-O', 'sympathetic-O', 'stimulation-O', 'were-O', 'evaluated-O', 'under-O', 'baseline-O', 'and-O', 'posttreatment-O', 'conditions-O', '.-O']
['Resting-O', 'values-O', 'of-O', 'LVEF-O', ',-O', 'FS-O', ',+-O', 'LVdP-O', '/-O', 'dt-O', ',-O', 'and-O', 'MBP-O', 'remained-O', 'unchanged-O', 'whatever-O', 'the-O', 'drug-O', 'and-O', 'the-O', 'dosing-O', 'regimen-O', ',-O', 'whereas-O', 'resting-O', 'HR-O', 'was-O', 'significantly-O', 'and-O', 'dose-O', ',-O', 'dependently-O', 'lowered-O', 'after-O', 'dronedarone-B-Chemical', 'and-O', 'to-O', 'a-O', 'lesser-O', 'extent-O', 'after-O', 'amiodarone-B-Chemical', '.-O']
['Both-O', 'dronedarone-B-Chemical', 'and-O', 'amiodarone-B-Chemical', 'significantly-O', 'reduced-O', 'the-O', 'exercise-O', ',-O', 'induced-O', 'tachycardia-B-Disease', 'and-O', ',-O', 'at-O', 'the-O', 'highest-O', 'dose-O', ',-O', 'decreased-O', 'the-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'tachycardia-B-Disease', '.-O']
['Thus-O', ',-O', 'dronedarone-B-Chemical', 'and-O', 'amiodarone-B-Chemical', 'displayed-O', 'a-O', 'similar-O', 'level-O', 'of-O', 'antiadrenergic-O', 'effect-O', 'and-O', 'did-O', 'not-O', 'impair-O', 'the-O', 'resting-O', 'left-O', 'ventricular-O', 'function-O', '.-O']
['Consequently-O', ',-O', 'dronedarone-B-Chemical', 'might-O', 'be-O', 'particularly-O', 'suitable-O', 'for-O', 'the-O', 'treatment-O', 'and-O', 'prevention-O', 'of-O', 'various-O', 'clinical-O', 'arrhythmias-B-Disease', '.-O']
['Phase-O', '2-O', 'trial-O', 'of-O', 'liposomal-O', 'doxorubicin-B-Chemical', '(-O', '40-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', '))-O', 'in-O', 'platinum-B-Chemical', '/-O', 'paclitaxel-B-Chemical', ',-O', 'refractory-O', 'ovarian-B-Disease', 'and-O', 'fallopian-O', 'tube-O', 'cancers-I-Disease', 'and-O', 'primary-O', 'carcinoma-I-Disease', 'of-O', 'the-O', 'peritoneum-B-Disease', '.-O']
['BACKGROUND-O', ':-O', 'Several-O', 'studies-O', 'have-O', 'demonstrated-O', 'liposomal-O', 'doxorubicin-B-Chemical', '(-O', 'Doxil-B-Chemical', ')-O', 'to-O', 'be-O', 'an-O', 'active-O', 'antineoplastic-O', 'agent-O', 'in-O', 'platinum-O', ',-O', 'resistant-O', 'ovarian-B-Disease', 'cancer-I-Disease', ',-O', 'with-O', 'dose-O', 'limiting-O', 'toxicity-O', 'of-O', 'the-O', 'standard-O', 'dosing-O', 'regimen-O', '(-O', '50-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'q-O', '4-O', 'weeks-O', ')-O', 'being-O', 'severe-O', 'erythrodysesthesia-B-Disease', '(-O', 'hand-foot-B-Disease', 'syndrome-I-Disease', ')-O', 'and-O', 'stomatitis-B-Disease', '.-O']
['We-O', 'wished-O', 'to-O', 'develop-O', 'a-O', 'more-O', 'tolerable-O', 'liposomal-O', 'doxorubicin-B-Chemical', 'treatment-O', 'regimen-O', 'and-O', 'document-O', 'its-O', 'level-O', 'of-O', 'activity-O', 'in-O', 'a-O', 'well-O', ',-O', 'defined-O', 'patient-O', 'population-O', 'with-O', 'platinum-B-Chemical', '/-O', 'paclitaxel-B-Chemical', ',-O', 'refractory-O', 'disease-O', '.-O']
['METHODS-O', 'AND-O', 'MATERIALS-O', ':-O', 'Patients-O', 'with-O', 'ovarian-B-Disease', 'or-O', 'fallopian-O', 'tube-O', 'cancers-O', 'or-O', 'primary-O', 'peritoneal-O', 'carcinoma-O', 'with-O', 'platinum-B-Chemical', '/-O', 'paclitaxel-B-Chemical', ',-O', 'refractory-O', 'disease-O', '(-O', 'stable-O', 'or-O', 'progressive-O', 'disease-O', 'following-O', 'treatment-O', 'with-O', 'these-O', 'agents-O', 'or-O', 'previous-O', 'objective-O', 'response-O', '<-O', '3-O', 'months-O', 'in-O', 'duration-O', ')-O', 'were-O', 'treated-O', 'with-O', 'liposomal-O', 'doxorubicin-B-Chemical', 'at-O', 'a-O', 'dose-O', 'of-O', '40-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'q-O', '4-O', 'weeks-O', '.-O']
['RESULTS-O', ':-O', 'A-O', 'total-O', 'of-O', '49-O', 'patients-O', '(-O', 'median-O', 'age-O', ':-O', '60-O', ';-O', 'range-O', '41-O', ',-O', '81-O', ')-O', 'entered-O', 'this-O', 'phase-O', '2-O', 'trial-O', '.-O']
['The-O', 'median-O', 'number-O', 'of-O', 'prior-O', 'regimens-O', 'was-O', '2-O', '(-O', 'range-O', ':-O', '1-O', ',-O', '6-O', ').-O', 'Six-O', '(-O', '12-O', ')-O', 'and-O', '4-O', '(-O', '8-O', ')-O', 'patients-O', 'experienced-O', 'grade-O', '2-O', 'hand-foot-O', 'syndrome-B-Disease', 'and-O', 'stomatitis-B-Disease', ',-O', 'respectively-O', '(-O', 'no-O', 'episodes-O', 'of-O', 'grade-O', '3-O', ').-O', 'One-O', 'patient-O', 'developed-O', 'grade-O', '3-O', 'diarrhea-B-Disease', 'requiring-O', 'hospitalization-O', 'for-O', 'hydration-O', '.-O']
['Six-O', '(-O', '12-O', ')-O', 'individuals-O', 'required-O', 'dose-O', 'reductions-O', '.-O']
['The-O', 'median-O', 'number-O', 'of-O', 'courses-O', 'of-O', 'liposomal-O', 'doxorubicin-B-Chemical', 'administered-O', 'on-O', 'this-O', 'protocol-O', 'was-O', '2-O', '(-O', 'range-O', ':O', '1-O', ',-O', '12-O', ').-O', 'Four-O', 'of-O', '44-O', 'patients-O', '(-O', '9-O', ')-O', 'evaluable-O', 'for-O', 'response-O', 'exhibited-O', 'objective-O', 'and-O', 'subjective-O', 'evidence-O', 'of-O', 'an-O', 'antineoplastic-O', 'effect-O', 'of-O', 'therapy-O', '.-O']
['CONCLUSION-O', ':-O', 'This-O', 'modified-O', 'liposomal-O', 'doxorubicin-B-Chemical', 'regimen-O', 'results-O', 'in-O', 'less-O', 'toxicity-O', '(-O', 'stomatitis-B-Disease', ',-O', 'hand-foot-B-Disease', 'syndrome-I-Disease', ')-O', 'than-O', 'the-O', 'standard-O', 'FDA-O', ',-O', 'approved-O', 'dose-O', 'schedule-O', '.-O']
['Definite-O', ',-O', 'although-O', 'limited-O', ',-O', 'antineoplastic-O', 'activity-O', 'is-O', 'observed-O', 'in-O', 'patients-O', 'with-O', 'well-O', ',-O', 'defined-O', 'platinum-B-Chemical', ',-O', 'and-O', 'paclitaxel-B-Chemical', ',-O', 'refractory-O', 'ovarian-B-Disease', 'cancer-I-Disease']
['Efficacy-O', 'of-O', 'olanzapine-B-Chemical', 'in-O', 'acute-O', 'bipolar-B-Disease', 'mania-I-Disease', ':-O', 'a-O', 'double-O', ',-O', 'blind-O', ',-O', 'placebo-O', ',-O', 'controlled-O', 'study-O', '.-O']
['The-O', 'Olanzipine-B-Chemical', 'HGGW-O', 'Study-O', 'Group-O', '.-O']
['BACKGROUND-O', ':-O', 'We-O', 'compared-O', 'the-O', 'efficacy-O', 'and-O', 'safety-O', 'of-O', 'olanzapine-B-Chemical', 'vs-O', 'placebo-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'acute-O', 'bipolar-B-Disease', 'mania-B-Disease', '.-O']
['METHODS-O', ':-O', 'Four-O', ',-O', 'week-O', ',-O', 'randomized-O', ',-O', 'double-O', ',-O', 'blind-O', ',-O', 'parallel-O', 'study-O', '.-O']
['A-O', 'total-O', 'of-O', '115-O', 'patients-O', 'with-O', 'a-O', 'DSM-O', ',-O', 'IV-O', 'diagnosis-O', 'of-O', 'bipolar-B-Disease', 'disorder-I-Disease', ',-O', 'manic-B-Disease', 'or-O', 'mixed-O', ',-O', 'were-O', 'randomized-O', 'to-O', 'olanzapine-B-Chemical', ',-O', '5-O', 'to-O', '20-O', 'mg-O', '/-O', 'd-O', '(-O', 'n-O', '=O', '55-O', '),', '-O', 'or-O', 'placebo-O', '(-O', 'n-O', '=O', '60-O', ').', 'The-O', 'primary-O', 'efficacy-O', 'measure-O', 'was-O', 'the-O', 'Young-O', ',-O', 'Mania-O', 'Rating-O', 'Scale-O', '(-O', 'Y-O', ',-O', 'MRS-O', ')', 'total-O', 'score-O', '.-O']
['Response-O', 'and-O', 'euthymia-O', 'were-O', 'defined-O', ',-O', 'a-O', 'priori-O', ',-O', 'as-O', 'at-O', 'least-O', 'a-O', '50-O', '%-O', 'improvement-O', 'from-O', 'baseline-O', 'to-O', 'end-O', 'point-O', 'and-O', 'as-O', 'a-O', 'score-O', 'of-O', 'no-O', 'less-O', 'than-O', '12-O', 'at-O', 'end-O', 'point-O', 'in-O', 'the-O', 'Y-O', ',', 'MRS-O', 'total-O', 'score-O', ',-O', 'respectively-O', '.-O']
['Safety-O', 'was-O', 'assessed-O', 'using-O', 'adverse-O', 'events-O', ',-O', 'Extrapyramidal-B-Disease', 'Symptom-O', '(-O', 'EPS-B-Disease', ')', 'rating-O', 'scales-O', ',-O', 'laboratory-O', 'values-O', ',-O', 'electrocardiograms-O', ',-O', 'vital-O', 'signs-O', ',-O', 'and-O', 'weight-O', 'change-O', '.-O']
['RESULTS-O', ':-O', 'Olanzapine-B-Chemical', ',-O', 'treated-O', 'patients-O', 'demonstrated-O', 'a-O', 'statistically-O', 'significant-O', 'greater-O', 'mean-O', '(+-O', 'SD-O', ')-O', 'improvement-O', 'in-O', 'Y-O', 'MRS-O', 'total-O', 'score-O', 'than-O', 'placebo-O', ',-O', 'treated-O', 'patients-O', '(-O', '14-O', '.-O']
['8-O', '+-O', '12-O', '.-O']
['5-O', 'and-O', ',-O', '8-O', '.-O']
['1-O', '+-O', '12-O', '.-O']
['7-O', ',-O', 'respectively-O', ';-O', 'P-O', '<.-O', '001-O', ')-O', 'which-O', 'was-O', 'evident-O', 'at-O', 'the-O', 'first-O', 'postbaseline-O', 'observation-O', '1-O', 'week-O', 'after-O', 'randomization-O', 'and-O', 'was-O', 'maintained-O', 'throughout-O', 'the-O', 'study-O', '(-O', 'last-O', 'observation-O', 'carried-O', 'forward-O', ')-O', 'Olanzapine-B-Chemical', ',-O', 'treated-O', 'patients-O', 'demonstrated-O', 'a-O', 'higher-O', 'rate-O', 'of-O', 'response-O', '(-O', '65-O', '%-O', 'vs-O', '43-O', ',-O', 'respectively-O', ';-O', 'P-O', '=.-O', '02-O', ')-O', 'and-O', 'euthymia-O', '(-O', '61-O', '%-O', 'vs-O', '36-O', ',-O', 'respectively-O', ';-O', 'P-O', '=.-O', '01-O', ')-O', 'than-O', 'placebo-O', ',-O', 'treated-O', 'patients-O', '.-O']
['There-O', 'were-O', 'no-O', 'statistically-O', 'significant-O', 'differences-O', 'in-O', 'EPSs-B-Disease', 'between-O', 'groups-O', '.-O']
['However-O', ',-O', 'olanzapine-B-Chemical', ',-O', 'treated-O', 'patients-O', 'had-O', 'a-O', 'statistically-O', 'significant-O', 'greater-O', 'mean-O', '(+-O', 'SD-O', ')-O', 'weight-O', 'gain-O', 'than-O', 'placebo-O', ',-O', 'treated-O', 'patients-O', '(-O', '2-O', '.-O']
['1-O', '+-O', '2-O', '.-O']
['8-O', 'vs-O', '0-O', '.-O']
['45-O', '+-O', '2-O', '.-O']
['3-O', 'kg-O', ',-O', 'respectively-O', ')-O', 'and-O', 'also-O', 'experienced-O', 'more-O', 'treatment-O', ',-O', 'emergent-O', 'somnolence-B-Disease', '(-O', '21-O', 'patients-O', '[-O', '38-O', '.-O']
['2-O', '%]-O', 'vs-O', '5-O', '[-O', '8-O', '.-O']
['3-O', '%]-O', 'respectively-O', ')-O', 'CONCLUSION-O', ':-O', 'Olanzapine-B-Chemical', 'demonstrated-O', 'greater-O', 'efficacy-O', 'than-O', 'placebo-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'acute-O', 'bipolar-B-Disease', 'mania-B-Disease']
['The-O', 'effect-O', 'of-O', 'pupil-O', 'dilation-O', 'with-O', 'tropicamide-B-Chemical', 'on-O', 'vision-O', 'and-O', 'driving-O', 'simulator-O', 'performance-O', '.-O']
['PURPOSE-O', ':-O', 'To-O', 'assess-O', 'the-O', 'effect-O', 'of-O', 'pupil-O', 'dilation-O', 'on-O', 'vision-O', 'and-O', 'driving-O', 'ability-O', '.-O']
['METHODS-O', ':', 'A-O', 'series-O', 'of-O', 'tests-O', 'on-O', 'various-O', 'parameters-O', 'of-O', 'visual-O', 'function-O', 'and-O', 'driving-O', 'simulator-O', 'performance-O', 'were-O', 'performed-O', 'on-O', '12-O', 'healthy-O', 'drivers-O', ',-O', 'before-O', 'and-O', 'after-O', 'pupil-O', 'dilation-O', 'using-O', 'guttae-O', 'tropicamide-B-Chemical', '1-O', '.-O', 'A-O', 'driving-O', 'simulator-O', '(-O', 'Transport-O', 'Research-O', 'Laboratory-O', ')-O', 'was-O', 'used-O', 'to-O', 'measure-O', 'reaction-O', 'time-O', '(-O', 'RT-O', ')-O', ',-O', 'speed-O', 'maintenance-O', 'and-O', 'steering-O', 'accuracy-O', '.-O']
['Tests-O', 'of-O', 'basic-O', 'visual-O', 'function-O', 'included-O', 'high-O', ',-O', 'and-O', 'low-O', ',-O', 'contrast-O', 'visual-O', 'acuity-O', '(-O', 'HCVA-O', 'and-O', 'LCVA-O', ')-O', 'Pelli-O', ',-O', 'Robson-O', 'contrast-O', 'threshold-O', '(-O', 'CT-O', ')-O', 'and-O', 'Goldmann-O', 'perimetry-O', '(-O', 'FIELDS-O', ')-O', 'Useful-O', 'Field-O', 'of-O', 'View-O', '(-O', 'UFOV-O', '--O', 'a-O', 'test-O', 'of-O', 'visual-O', 'attention-O', ')-O', 'was-O', 'also-O', 'undertaken-O', '.-O']
['The-O', 'mean-O', 'differences-O', 'in-O', 'the-O', 'pre-O', ',-O', 'and-O', 'post-O', ',-O', 'dilatation-O', 'measurements-O', 'were-O', 'tested-O', 'for-O', 'statistical-O', 'significance-O', 'at-O', 'the-O', '95-O', '%-O', 'level-O', 'using-O', 'one-O', ',-O', 'tail-O', 'paired-O', 't-O', ',-O', 'tests-O', '.-O']
['RESULTS-O', ':-O', 'Pupillary-O', 'dilation-O', 'resulted-O', 'in-O', 'a-O', 'statistically-O', 'significant-O', 'deterioration-O', 'in-O', 'CT-O', 'and-O', 'HCVA-O', '.-O']
['Five-O', 'of-O', '12-O', 'drivers-O', 'also-O', 'exhibited-O', 'deterioration-B-Disease', 'in-O', 'LCVA-O', ',-O', 'CT-O', 'and-O', 'RT-O', '.-O']
['Little-O', 'evidence-O', 'emerged-O', 'for-O', 'deterioration-O', 'in-O', 'FIELDS-O', 'and-O', 'UFOV-O', '.-O']
['Also-O', ',-O', '7-O', 'of-O', '12-O', 'drivers-O', 'appeared-O', 'to-O', 'adjust-O', 'their-O', 'driving-O', 'behaviour-O', 'by-O', 'reducing-O', 'their-O', 'speed-O', 'on-O', 'the-O', 'driving-O', 'simulator-O', ',-O', 'leading-O', 'to-O', 'improved-O', 'steering-O', 'accuracy-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Pupillary-B-Disease', 'dilation-O']
['A-O', 'case-O', 'of-O', 'isotretinoin-B-Chemical', 'embryopathy-B-Disease', 'with-O', 'bilateral-O', 'anotia-B-Disease', 'and-O', 'Taussig-Bing-B-Disease', 'malformation-I-Disease', '.-O']
['We-O', 'report-O', 'a-O', 'newborn-O', 'infant-O', 'with-O', 'multiple-O', 'congenital-O', 'anomalies-O', '(-O', 'anotia-B-Disease', 'and-O', 'Taussig-Bing-B-Disease', 'malformation-I-Disease', ')-O', 'due-O', 'to-O', 'exposure-O', 'to-O', 'isotretinoin-B-Chemical', 'within-O', 'the-O', 'first-O', 'trimester-O', '.-O']
['In-O', 'this-O', 'paper-O', 'we-O', 'aim-O', 'to-O', 'draw-O', 'to-O', 'the-O', 'fact-O', 'that-O', 'caution-O', 'is-O', 'needed-O', 'when-O', 'prescribing-O', 'vitamin-B-Chemical', 'A-I-Chemical']
['Effect-O', 'of-O', 'methoxamine-B-Chemical', 'on-O', 'maximum-O', 'urethral-O', 'pressure-O', 'in-O', 'women-O', 'with-O', 'genuine-O', 'stress-B-Disease', 'incontinence-I-Disease', ':-O', 'a-O', 'placebo-O', ',-O', 'controlled-O', ',-O', 'double-O', ',-O', 'blind-O', 'crossover-O', 'study-O', '.-O']
['The-O', 'aim-O', 'of-O', 'the-O', 'study-O', 'was-O', 'to-O', 'evaluate-O', 'the-O', 'potential-O', 'role-O', 'for-O', 'a-O', 'selective-O', 'alpha1-O', ',-O', 'adrenoceptor-O', 'agonist-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'urinary-B-Disease', 'stress-B-Disease', 'incontinence-I-Disease', '.-O']
['A-O', 'randomised-O', ',-O', 'double-O', ',-O', 'blind-O', ',-O', 'placebo-O', ',-O', 'controlled-O', ',-O', 'crossover-O', 'study-O', 'design-O', 'was-O', 'employed-O', '.-O']
['Half-O', 'log-O', 'incremental-O', 'doses-O', 'of-O', 'intravenous-O', 'methoxamine-B-Chemical', 'or-O', 'placebo-O', '(-O', 'saline-O', ')-O', 'were-O', 'administered-O', 'to-O', 'a-O', 'group-O', 'of-O', 'women-O', 'with-O', 'genuine-O', 'stress-B-Disease', 'incontinence-I-Disease', 'while-O', 'measuring-O', 'maximum-O', 'urethral-O', 'pressure-O', '(-O', 'MUP-O', ')-O', 'blood-O', 'pressure-O', ',-O', 'heart-O', 'rate-O', ',-O', 'and-O', 'symptomatic-O', 'side-O', 'effects-O', '.-O']
['Methoxamine-B-Chemical', 'evoked-O', 'non-O', ',-O', 'significant-O', 'increases-O', 'in-O', 'MUP-O', 'and-O', 'diastolic-O', 'blood-O', 'pressure-O', 'but-O', 'caused-O', 'a-O', 'significant-O', 'rise-O', 'in-O', 'systolic-O', 'blood-O', 'pressure-O', 'and-O', 'significant-O', 'fall-O', 'in-O', 'heart-O', 'rate-O', 'at-O', 'maximum-O', 'dosage-O', '.-O']
['Systemic-O', 'side-O', 'effects-O', 'including-O', 'piloerection-B-Disease', ',-O', 'headache-B-Disease', ',-O', 'and-O', 'cold-O', 'extremities-O', 'were-O', 'experienced-O', 'in-O', 'all-O', 'subjects-O', '.-O']
['The-O', 'results-O', 'indicate-O', 'that-O', 'the-O', 'clinical-O', 'usefulness-O', 'of-O', 'direct-O', ',-O', 'peripherally-O', 'acting-O', 'sub-O', ',-O', 'type-O', ',-O', 'selective-O', 'alpha1-O', ',-O', 'adrenoceptor-O', 'agonists-O', 'in-O', 'the-O', 'medical-O', 'treatment-O', 'of-O', 'stress-B-Disease', 'incontinence-I-Disease']
['Toleration-O', 'of-O', 'high-O', 'doses-O', 'of-O', 'angiotensin-B-Chemical', '-converting-O', 'enzyme-O', 'inhibitors-O', 'in-O', 'patients-O', 'with-O', 'chronic-B-Disease', 'heart-O', 'failure-I-Disease', ':-O', 'results-O', 'from-O', 'the-O', 'ATLAS-O', 'trial-O', '.-O']
['The-O', 'Assessment-O', 'of-O', 'Treatment-O', 'with-O', 'Lisinopril-B-Chemical', 'and-O', 'Survival-O', '.-O']
['BACKGROUND-O', ':-O', 'Treatment-O', 'with-O', 'angiotensin-converting-B-Chemical', 'enzyme-O', '(ACE)-O', 'inhibitors-O', 'reduces-O', 'mortality-O', 'and-O', 'morbidity-O', 'in-O', 'patients-O', 'with-O', 'chronic-O', 'heart-O', 'failure-O', '(-O', 'CHF-O', ')-O', ',', 'but-O', 'most-O', 'affected-O', 'patients-O', 'are-O', 'not-O', 'receiving-O', 'these-O', 'agents-O', 'or-O', 'are-O', 'being-O', 'treated-O', 'with-O', 'doses-O', 'lower-O', 'than-O', 'those-O', 'found-O', 'to-O', 'be-O', 'efficacious-O', 'in-O', 'trials-O', ',-O', 'primarily-O', 'because-O', 'of-O', 'concerns-O', 'about-O', 'the-O', 'safety-O', 'and-O', 'tolerability-O', 'of-O', 'these-O', 'agents-O', ',-O', 'especially-O', 'at-O', 'the-O', 'recommended-O', 'doses-O', '.-O']
['The-O', 'present-O', 'study-O', 'examines-O', 'the-O', 'safety-O', 'and-O', 'tolerability-O', 'of-O', 'high-O', ',-O', 'compared-O', 'with-O', 'low-O', ',-O', 'dose-O', 'lisinopril-B-Chemical', 'in-O', 'CHF-B-Disease', '.-O']
['METHODS-O', ':-O', 'The-O', 'Assessment-O', 'of-O', 'Lisinopril-B-Chemical', 'and-O', 'Survival-O', 'study-O', 'was-O', 'a-O', 'multicenter-O', ',-O', 'randomized-O', ',-O', 'double-O', ',-O', 'blind-O', 'trial-O', 'in-O', 'which-O', 'patients-O', 'with-O', 'or-O', 'without-O', 'previous-O', 'ACE-B-Chemical', 'inhibitor-O', 'treatment-O', 'were-O', 'stabilized-O', 'receiving-O', 'medium-O', ',-O', 'dose-O', 'lisinopril-B-Chemical', '(-O', '12-O', '.-O']
['5-O', 'or-O', '15-O', '.-O']
['0-O', 'mg-O', 'once-O', 'daily-O', '[', 'OD-O', ']-O', 'for-O', '2-O', 'to-O', '4-O', 'weeks-O', 'and-O', 'then-O', 'randomized-O', 'to-O', 'high-O', '-(-O', '35-O', '.-O']
['0-O', 'or-O', '32-O', '.-O']
['5-O', 'mg-O', 'OD-O', ')-O', 'or-O', 'low-O', ',-O', 'dose-O', '(-O', '5-O', '.-O']
['0-O', 'or-O', '2-O', '.-O']
['5-O', 'mg-O', 'OD-O', ')-O', 'groups-O', '.-O']
['Patients-O', 'with-O', 'New-O', 'York-O', 'Heart-O', 'Association-O', 'classes-O', 'II-O', 'to-O', 'IV-O', 'CHF-B-Disease', 'and-O', 'left-O', 'ventricular-O', 'ejection-O', 'fractions-O', 'of-O', 'no-O', 'greater-O', 'than-O', '0-O', '.-O']
['30-O', '(-O', 'n-O', '=-O', '3164-O', ')-O', 'were-O', 'randomized-O', 'and-O', 'followed-O', 'up-O', 'for-O', 'a-O', 'median-O', 'of-O', '46-O', 'months-O', '.-O']
['We-O', 'examined-O', 'the-O', 'occurrence-O', 'of-O', 'adverse-O', 'events-O', 'and-O', 'the-O', 'need-O', 'for-O', 'discontinuation-O', 'and-O', 'dose-O', 'reduction-O', 'during-O', 'treatment-O', ',-O', 'with-O', 'a-O', 'focus-O', 'on-O', 'hypotension-B-Disease', 'and-O', 'renal-B-Disease', 'dysfunction-I-Disease', '.-O']
['RESULTS-O', ':-O', 'Of-O', '405-O', 'patients-O', 'not-O', 'previously-O', 'receiving-O', 'an-O', 'ACE-B-Chemical', 'inhibitor-I-Chemical', ',-O', 'doses-O', 'in-O', 'only-O', '4-O', '.-O']
['2-O', '%-O', 'could-O', 'not-O', 'be-O', 'titrated-O', 'to-O', 'the-O', 'medium-O', 'doses-O', 'required-O', 'for-O', 'randomization-O', 'because-O', 'of-O', 'symptoms-O', 'possibly-O', 'related-O', 'to-O', 'hypotension-B-Disease', '(-O', '2-O', '.-O']
['0-O', ')-O', 'or-O', 'because-O', 'of-O', 'renal-B-Disease', 'dysfunction-I-Disease', 'or-O', 'hyperkalemia-B-Disease', '(-O', '2-O', '.-O']
['3-O', ').-O', 'Doses-O', 'in-O', 'more-O', 'than-O', '90-O', '%-O', 'of-O', 'randomized-O', 'patients-O', 'in-O', 'the-O', 'high-O', ',-O', 'and-O', 'low-O', ',-O', 'dose-O', 'groups-O', 'were-O', 'titrated-O', 'to-O', 'their-O', 'assigned-O', 'target-O', ',-O', 'and-O', 'the-O', 'mean-O', 'doses-O', 'of-O', 'blinded-O', 'medication-O', 'in-O', 'both-O', 'groups-O', 'remained-O', 'similar-O', 'throughout-O', 'the-O', 'study-O', '.-O']
['Withdrawals-O', 'occurred-O', 'in-O', '27-O', '.-O']
['1-O', '%-O', 'of-O', 'the-O', 'high-O', ',-O', 'and-O', '30-O', '.-O']
['7-O', '%-O', 'of-O', 'the-O', 'low-O', ',-O', 'dose-O', 'groups-O', '.-O']
['Subgroups-O', 'presumed-O', 'to-O', 'be-O', 'at-O', 'higher-O', 'risk-O', 'for-O', 'ACE-B-Chemical', 'inhibitor-O', 'intolerance-O', '(-O', 'blood-O', 'pressure-O', ',<O', '120-O', 'mm-O', 'Hg-O', ';-O', 'creatinine-B-Chemical', ',>-O', 'or-O', '=-O', '132-O', '.-O']
['6-O', 'micromol-O', '/-O', 'L-O', '[>-O', 'or-O', '=-O', '1-O', '.-O']
['5-O', 'mg-O', '/-O', 'dL-O', '];-O', 'age-O', ',>-O', 'or-O', '=-O', '70-O', 'years-O', ';-O', 'and-O', 'patients-O', 'with-O', 'diabetes-B-Disease', ')-O', 'generally-O', 'tolerated-O', 'the-O', 'high-O', ',-O', 'dose-O', 'strategy-O', '.-O']
['CONCLUSIONS-O', ':-O', 'These-O', 'findings-O', 'demonstrate-O', 'that-O', 'ACE-B-Chemical', 'inhibitor-O', 'therapy-O', 'in-O', 'most-O', 'patients-O', 'with-O', 'CHF-B-Disease']
['Cocaine-B-Chemical', ',-O', 'ethanol-B-Chemical', ',-O', 'and-O', 'cocaethylene-B-Chemical', 'cardiotoxity-O', 'in-O', 'an-O', 'animal-O', 'model-O', 'of-O', 'cocaine-B-Chemical', 'and-O', 'ethanol-B-Chemical', 'abuse-O', '.-O']
['OBJECTIVES-O', ':-O', 'Simultaneous-O', 'abuse-O', 'of-O', 'cocaine-B-Disease', 'and-O', 'ethanol-B-Chemical', 'affects-O', '12-O', 'million-O', 'Americans-O', 'annually-O', '.-O']
['In-O', 'combination-O', ',-O', 'these-O', 'substances-O', 'are-O', 'substantially-O', 'more-O', 'toxic-O', 'than-O', 'either-O', 'drug-O', 'alone-O', '.-O']
['Their-O', 'combined-O', 'cardiac-O', 'toxicity-B-Disease', 'may-O', 'be-O', 'due-O', 'to-O', 'independent-O', 'effects-O', 'of-O', 'each-O', 'drug-O', ';-O', 'however-O', ',-O', 'they-O', 'may-O', 'also-O', 'be-O', 'due-O', 'to-O', 'cocaethylene-B-Chemical', '(-O', 'CE-O', ')-O', 'a-O', 'cocaine-B-Chemical', 'metabolite-O', 'formed-O', 'only-O', 'in-O', 'the-O', 'presence-O', 'of-O', 'ethanol-B-Chemical', '.-O']
['The-O', 'purpose-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'delineate-O', 'the-O', 'role-O', 'of-O', 'CE-O', 'in-O', 'the-O', 'combined-O', 'cardiotoxicity-O', 'of-O', 'cocaine-B-Chemical', 'and-O', 'ethanol-B-Chemical', 'in-O', 'a-O', 'model-O', 'simulating-O', 'their-O', 'abuse-O', '.-O']
['METHODS-O', ':-O', 'Twenty-O', ',-O', 'three-O', 'dogs-O', 'were-O', 'randomized-O', 'to-O', 'receive-O', 'either-O', '1-O', ')-O', 'three-O', 'intravenous-O', '(-O', 'IV-O', ')-O', 'boluses-O', 'of-O', 'cocaine-B-Chemical', '7-O', '.-O']
['5-O', 'mg-O', '/-O', 'kg-O', 'with-O', 'ethanol-B-Chemical', '(-O', '1-O', 'g-O', '/-O', 'kg-O', ')-O', 'as-O', 'an-O', 'IV-O', 'infusion-O', '(-O', 'C-O', '+-O', 'E-O', ',-O', 'n-O', '=O', '8-O', ')-O', '2-O', ')', 'three-O', 'cocaine-B-Chemical', 'boluses-O', 'only-O', '(-O', 'C-O', ',-O', 'n-O', '=O', '6-O', ')-O', '3-O', ')', 'ethanol-B-Chemical', 'infusion-O', 'only-O', '(-O', 'E-O', ',-O', 'n-O', '=O', '5-O', ')-O', ',-O', 'or-O', '4-O', ')', 'placebo-O', 'boluses-O', 'and-O', 'infusion-O', '(-O', 'n-O', '=O', '4-O', ')-O', '.-O', 'Hemodynamic-O', 'measurements-O', ',-O', 'electrocardiograms-O', ',-O', 'and-O', 'serum-O', 'drug-O', 'concentrations-O', 'were-O', 'obtained-O', 'at-O', 'baseline-O', ',-O', 'and-O', 'then-O', 'at-O', 'fixed-O', 'time-O', 'intervals-O', 'after-O', 'each-O', 'drug-O', 'was-O', 'administered-O', '.-O']
['RESULTS-O', ':-O', 'Two-O', 'of-O', 'eight-O', 'dogs-O', 'in-O', 'the-O', 'C-O', '+-O', 'E-O', 'group-O', 'experienced-O', 'cardiovascular-B-Disease', 'collapse-O', '.-O']
['The-O', 'most-O', 'dramatic-O', 'hemodynamic-O', 'changes-O', 'occurred-O', 'after-O', 'each-O', 'cocaine-B-Chemical', 'bolus-O', 'in-O', 'the-O', 'C-O', '+-O', 'E-O', 'and-O', 'C-O', 'only-O', 'groups-O', ';-O', 'however-O', ',-O', 'persistent-O', 'hemodynamic-O', 'changes-O', 'occurred-O', 'in-O', 'the-O', 'C-O', '+-O', 'E-O', 'group-O', '.-O']
['Peak-O', 'CE-O', 'levels-O', 'were-O', 'associated-O', 'with-O', 'a-O', '45-O', '(-O', 'SD-O', '+-O', '22-O', ',-O', '95-O', '%-O', 'CI-O', '=-O', '22-O', '%-O', 'to-O', '69-O', ')-O', 'decrease-O', 'in-O', 'cardiac-O', 'output-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ')-O', 'a-O', '56-O', '(-O', 'SD-O', '+-O', '23-O', ',-O', '95-O', '%-O', 'CI-O', '=-O', '32-O', '%-O', 'to-O', '80-O', ')-O', 'decrease-O', 'in-O', 'dP-O', '/-O', 'dt-O', '(-O', 'max-O', ')-O', '(-O', 'p-O', '<.-O', '006-O', ')-O', 'and-O', 'a-O', '23-O', '(-O', 'SD-O', '+-O', '15-O', ',-O', '95-O', '%-O', 'CI-O', '=-O', '7-O', '%-O', 'to-O', '49-O', ')-O', 'decrease-O', 'in-O', 'SVO-O', '(-O', '2-O', ')-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['025-O', ').-O', 'Ventricular-O', 'arrhythmias-O', 'were-O', 'primarily-O', 'observed-O', 'in-O', 'the-O', 'C-O', '+-O', 'E-O', 'group-O', ',-O', 'in-O', 'which-O', 'four-O', 'of-O', 'eight-O', 'dogs-O', 'experienced-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', '.-O']
['CONCLUSIONS-O', ':-O', 'Cocaine-B-Chemical', 'and-O', 'ethanol-B-Chemical', 'in-O', 'combination-O', 'were-O', 'more-O', 'toxic-O', 'than-O', 'either-O', 'substance-O', 'alone-O', '.-O']
['Co-O', ',-O', 'administration-O', 'resulted-O', 'in-O', 'prolonged-O', 'cardiac-B-Disease', 'toxicity-I-Disease', 'and-O', 'was-O', 'dysrhythmogenic-O', '.-O']
['Peak-O', 'serum-O', 'cocaethylene-B-Chemical', 'concentrations-O', 'were-O', 'associated-O', 'with-O', 'prolonged-O', 'myocardial-B-Disease', 'depression-I-Disease']
['Worsening-O', 'of-O', 'Parkinsonism-B-Disease', 'after-O', 'the-O', 'use-O', 'of-O', 'veralipride-B-Chemical', 'for-O', 'treatment-O', 'of-O', 'menopause-O', ':-O', 'case-O', 'report-O', '.-O']
['We-O', 'describe-O', 'a-O', 'female-O', 'patient-O', 'with-O', 'stable-O', 'Parkinson-B-Disease', 'disease-I-Disease', 'who-O', 'has-O', 'shown-O', 'a-O', 'marked-O', 'worsening-O', 'of-O', 'her-O', 'motor-O', 'functions-O', 'following-O', 'therapy-O', 'of-O', 'menopause-O', 'related-O', 'symptoms-O', 'with-O', 'veralipride-B-Chemical', ',-O', 'as-O', 'well-O', 'as-O', 'the-O', 'improvement-O', 'of-O', 'her-O', 'symptoms-O', 'back-O', 'to-O', 'baseline-O', 'after-O', 'discontinuation-O', 'of-O', 'the-O', 'drug-O', '.-O']
['We-O', 'emphasize-O', 'the-O', 'anti-O', ',-O', 'dopaminergic-O', 'effect-O', 'of-O', 'veralipride-B-Chemical']
['Viracept-B-Chemical', 'and-O', 'irregular-B-Disease', 'heartbeat-B-Disease', 'warning-O', '.-O']
['A-O', 'group-O', 'of-O', 'doctors-O', 'in-O', 'Boston-O', 'warn-O', 'that-O', 'the-O', 'protease-O', 'inhibitor-O', 'Viracept-B-Chemical', 'may-O', 'cause-O', 'an-O', 'irregular-O', 'heart-O', 'beat-O', ',-O', 'known-O', 'as-O', 'bradycardia-B-Disease', ',-O', 'in-O', 'people-O', 'with-O', 'HIV-O', '.-O']
['Bradycardia-B-Disease', 'occurred-O', 'in-O', 'a-O', '45-O', ',-O', 'year-O', ',-O', 'old-O', 'male-O', 'patient-O', 'who-O', 'was-O', 'Viracept-B-Chemical']
['Frequency-O', 'of-O', 'appearance-O', 'of-O', 'myeloperoxidase-O', ',-O', 'antineutrophil-O', 'cytoplasmic-O', 'antibody-O', '(-O', 'MPO-O', ',-O', 'ANCA-O', ')-O', 'in-O', 'Graves-O', ''-B-Disease', 'disease-I-Disease', 'patients-O', 'treated-O', 'with-O', 'propylthiouracil-B-Chemical', 'and-O', 'the-O', 'relationship-O', 'between-O', 'MPO-O', ',-O', 'ANCA-O', 'and-O', 'clinical-O', 'manifestations-O', '.-O']
['OBJECTIVE-O', ':-O', 'Myeloperoxidase-O', 'antineutrophil-O', 'cytoplasmic-O', 'antibody-O', '(-O', 'MPO-O', ',-O', 'ANCA-O', ')-O', 'positive-O', 'vasculitis-B-Disease', 'has-O', 'been-O', 'reported-O', 'in-O', 'patients-O', 'with-O', 'Graves-B-Disease', 'disease-I-Disease', 'who-O', 'were-O', 'treated-O', 'with-O', 'propylthiouracil-B-Chemical', '(-O', 'PTU-O', ').-O', 'The-O', 'appearance-O', 'of-O', 'MPO-O', ',-O', 'ANCA-O', 'in-O', 'these-O', 'cases-O', 'was-O', 'suspected-O', 'of-O', 'being-O', 'related-O', 'to-O', 'PTU-B-Chemical', 'because-O', 'the-O', 'titres-O', 'of-O', 'MPO-O', ',-O', 'ANCA-O', 'decreased-O', 'when-O', 'PTU-B-Chemical', 'was-O', 'stopped-O', '.-O']
['Nevertheless-O', ',-O', 'there-O', 'have-O', 'been-O', 'no-O', 'studies-O', 'on-O', 'the-O', 'temporal-O', 'relationship-O', 'between-O', 'the-O', 'appearance-O', 'of-O', 'MPO-O', ',-O', 'ANCA-O', 'and-O', 'vasculitis-B-Disease', 'during-O', 'PTU-B-Chemical', 'therapy-O', ',-O', 'or-O', 'on-O', 'the-O', 'incidence-O', 'of-O', 'MPO-O', ',-O', 'ANCA-O', 'in-O', 'untreated-O', 'Graves''-B-Disease', 'disease-I-Disease', 'patients-O', '.-O']
['Therefore-O', ',-O', 'we-O', 'sought-O', 'to-O', 'address-O', 'these-O', 'parameters-O', 'in-O', 'patients-O', 'with-O', 'Graves-B-Disease', 'disease-I-Disease', '.-O']
['PATIENTS-O', ':-O', 'We-O', 'investigated-O', '102-O', 'untreated-O', 'patients-O', 'with-O', 'hyperthyroidism-B-Disease', 'due-O', 'to-O', 'Graves-B-Disease', 'disease-I-Disease', 'for-O', 'the-O', 'presence-O', 'of-O', 'MPO-O', ',-O', 'ANCA-O', ',-O', 'and-O', 'for-O', 'the-O', 'development-O', 'vasculitis-B-Disease', 'after-O', 'starting-O', 'PTU-B-Chemical', 'therapy-O', '.-O']
['Twenty-O', ',-O', 'nine-O', 'of-O', 'them-O', 'were-O', 'later-O', 'excluded-O', 'because-O', 'of-O', 'adverse-O', 'effects-O', 'of-O', 'PTU-B-Chemical', 'or-O', 'because-O', 'the-O', 'observation-O', 'period-O', 'was-O', 'less-O', 'than-O', '3-O', 'months-O', '.-O']
['The-O', 'remaining-O', '73-O', 'patients-O', '(-O', '55-O', 'women-O', 'and-O', '18-O', 'men-O', ')-O', 'all-O', 'of-O', 'whom-O', 'were-O', 'examined-O', 'for-O', 'more-O', 'than-O', '3-O', 'months-O', ',-O', 'were-O', 'adopted-O', 'as-O', 'the-O', 'subjects-O', 'of-O', 'the-O', 'investigation-O', '.-O']
['The-O', 'median-O', 'observation-O', 'period-O', 'was-O', '23-O', '.-O']
['6-O', 'months-O', '(-O', 'range-O', ':-O', '3-O', ',-O', '37-O', 'months-O', ').-O', 'MEASUREMENTS-O', ':-O', 'MPO-O', ',-O', 'ANCA-O', 'was-O', 'measured-O', 'at-O', 'intervals-O', 'of-O', '2-O', ',-O', '6-O', 'months-O', '.-O']
['RESULTS-O', ':-O', 'Before-O', 'treatment-O', ',-O', 'the-O', 'MPO-B-Chemical', ',-O', 'ANCA-B-Chemical', 'titres-O', 'of-O', 'all-O', '102-O', 'untreated-O', 'Graves-B-Disease', 'disease-I-Disease', 'patients-O', 'were-O', 'within-O', 'the-O', 'reference-O', 'range-O', '(-O', 'below-O', '10-O', 'U-O', '/-O', 'ml-O', ')-O', '.-O', 'Three-O', '(-O', '4-O', '.-O']
['1-O', ')-O', 'of-O', 'the-O', '73-O', 'patients-O', 'were-O', 'positive-O', 'for-O', 'MPO-B-Chemical', ',-O', 'ANCA-B-Chemical', 'at-O', '13-O', ',-O', '16-O', 'and-O', '17-O', 'months-O', ',-O', 'respectively-O', ',-O', 'after-O', 'the-O', 'start-O', 'of-O', 'PTU-B-Chemical', 'therapy-O', '.-O']
['In-O', 'two-O', 'of-O', 'them-O', ',-O', 'the-O', 'MPO-O', ',-O', 'ANCA-O', 'titres-O', 'transiently-O', 'increased-O', 'to-O', '12-O', '.-O']
['8-O', 'and-O', '15-O', '.-O']
['0-O', 'U-O', '/-O', 'ml-O', ',-O', 'respectively-O', ',-O', 'despite-O', 'continued-O', 'PTU-B-Chemical', 'therapy-O', ',-O', 'but-O', 'no-O', 'vasculitic-B-Disease', 'disorders-I-Disease', 'developed-O', '.-O']
['In-O', 'the-O', 'third-O', 'patient-O', ',-O', 'the-O', 'MPO-O', ',-O', 'ANCA-O', 'titre-O', 'increased-O', 'to-O', '204-O', 'U-O', '/-O', 'ml-O', 'and-O', 'she-O', 'developed-O', 'a-O', 'higher-O', 'fever-B-Disease', ',-O', 'oral-O', 'ulcers-B-Disease', 'and-O', 'polyarthralgia-B-Disease', ',-O', 'but-O', 'the-O', 'symptoms-O', 'resolved-O', '2-O', 'weeks-O', 'after-O', 'stopping-O', 'PTU-B-Chemical', 'therapy-O', ',-O', 'and-O', 'the-O', 'MPO-O', ',-O', 'ANCA-O', 'titre-O', 'decreased-O', 'to-O', '20-O', '.-O']
['7-O', 'U-O', '/-O', 'ml-O', 'by-O', '4-O', 'months-O', 'after-O', 'discontinuing-O', 'PTU-B-Chemical', '.-O']
['CONCLUSIONS-O', ':-O', 'PTU-B-Chemical', 'therapy-O', 'may-O', 'be-O', 'related-O', 'to-O', 'the-O', 'appearance-O', 'of-O', 'MPO-O', ',-O', 'ANCA-O', ',-O', 'but-O', 'MPO-O', ',-O', 'ANCA-O', 'does-O', 'not-O', 'appear-O', 'to-O', 'be-O', 'closely-O', 'related-O', 'to-O', 'vasculitis-B-Disease']
['Prevalence-O', 'of-O', 'heart-B-Disease', 'in-O', 'asymptomatic-O', 'chronic-O', 'cocaine-B-Chemical', 'users-O', '.-O']
['To-O', 'determine-O', 'the-O', 'prevalence-O', 'of-O', 'heart-B-Disease', 'in-O', 'outpatient-O', 'young-O', 'asymptomatic-O', 'chronic-O', 'cocaine-B-Chemical', 'users-O', ',-O', '35-O', 'cocaine-B-Chemical', 'users-O', 'and-O', '32-O', 'age-O', ',-O', 'matched-O', 'controls-O', 'underwent-O', 'resting-O', 'and-O', 'exercise-O', 'electrocardiography-O', '(-O', 'ECG-O', ')-O', 'and-O', 'Doppler-O', 'echocardiography-O', '.-O']
['Findings-O', 'consistent-O', 'with-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease', 'were-O', 'detected-O', 'in-O', '12-O', '(-O', '34-O', ')-O', 'patients-O', 'and-O', '3-O', '(-O', '9-O', ')-O', 'controls-O', '(-O', 'p-O', '=-O', '0-O', '.-O']
['01-O', ').-O', 'Decreased-O', 'left-O', 'ventricular-O', 'systolic-O', 'function-O', 'was-O', 'demonstrated-O', 'in-O', '5-O', '(-O', '14-O', ')-O', 'patients-O', ',-O', 'but-O', 'in-O', 'none-O', 'of-O', 'the-O', 'controls-O', '(-O', 'p-O', '=-O', '0-O', '.-O']
['055-O', ').-O', 'Finally-O', ',-O', 'resting-O', 'and-O', 'peak-O', 'exercise-O', 'abnormal-O', 'left-O', 'ventricular-O', 'filling-O', 'was-O', 'detected-O', 'in-O', '38-O', 'and-O', '35-O', '%-O', 'of-O', 'patients-O', 'as-O', 'compared-O', 'to-O', '19-O', 'and-O', '9-O', '%-O', 'of-O', 'controls-O', ',-O', 'respectively-O', '(-O', 'p-O', '=-O', '0-O', '.-O']
['11-O', 'and-O', '0-O', '.-O']
['02-O', ',-O', 'respectively-O', ')-O', '.', 'We-O', 'conclude-O', 'that-O', 'coronary-B-Disease', 'artery-I-Disease', 'or-O', 'myocardial-B-Disease', 'disease-I-Disease', 'is-O', 'common-O', '(-O', '38-O', ')-O', 'in-O', 'young-O', 'asymptomatic-O', 'chronic-O', 'cocaine-B-Chemical']
['Cardioprotective-O', 'effects-O', 'of-O', 'Picrorrhiza-B-Chemical', 'kurroa-B-Chemical', 'against-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'myocardial-B-Disease', 'stress-O', 'in-O', 'rats-O', '.-O']
['The-O', 'cardioprotective-O', 'effect-O', 'of-O', 'the-O', 'ethanol-B-Chemical', 'extract-O', 'of-O', 'Picrorrhiza-O', 'kurroa-O', 'rhizomes-O', 'and-O', 'roots-O', '(-O', 'PK-O', ')-O', 'on-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'in-O', 'rats-O', 'with-O', 'respect-O', 'to-O', 'lipid-O', 'metabolism-O', 'in-O', 'serum-O', 'and-O', 'heart-O', 'tissue-O', 'has-O', 'been-O', 'investigated-O', '.-O']
['Oral-O', 'pre-O', ',-O', 'treatment-O', 'with-O', 'PK-B-Chemical', '(-O', '80-O', 'mg-O', 'kg-O', '(-O', '1-O', ')-O', 'day-O', '(-O', '1-O', ')-O', 'for-O', '15-O', 'days-O', ')-O', 'significantly-O', 'prevented-O', 'the-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'myocardial-B-Disease', 'infarction-I-Disease']
['Phase-O', '2-O', 'early-O', 'afterdepolarization-O', 'as-O', 'a-O', 'trigger-O', 'of-O', 'polymorphic-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'in-O', 'acquired-O', 'long-QT-B-Disease', 'syndrome-I-Disease', ':-O', 'direct-O', 'evidence-O', 'from-O', 'intracellular-O', 'recordings-O', 'in-O', 'the-O', 'intact-O', 'left-O', 'ventricular-O', 'wall-O', '.-O']
['BACKGROUND-O', ':-O', 'This-O', 'study-O', 'examined-O', 'the-O', 'role-O', 'of-O', 'phase-O', '2-O', 'early-O', 'afterdepolarization-O', '(-O', 'EAD-O', ')-O', 'in-O', 'producing-O', 'a-O', 'trigger-O', 'to-O', 'initiate-O', 'torsade-O', 'de-O', 'pointes-O', '(-O', 'TdP-B-Disease', ')-O', 'with-O', 'QT-O', 'prolongation-O', 'induced-O', 'by-O', 'dl-O', ',-O', 'sotalol-B-Chemical', 'and-O', 'azimilide-B-Chemical', '.-O']
['The-O', 'contribution-O', 'of-O', 'transmural-O', 'dispersion-O', 'of-O', 'repolarization-O', '(-O', 'TDR-O', ')-O', 'to-O', 'transmural-O', 'propagation-O', 'of-O', 'EAD-O', 'and-O', 'the-O', 'maintenance-O', 'of-O', 'TdP-B-Disease', 'was-O', 'also-O', 'evaluated-O', '.-O']
['METHODS-O', 'AND-O', 'RESULTS-O', ':-O', 'Transmembrane-O', 'action-O', 'potentials-O', 'from-O', 'epicardium-O', ',-O', 'midmyocardium-O', ',-O', 'and-O', 'endocardium-O', 'were-O', 'recorded-O', 'simultaneously-O', ',-O', 'together-O', 'with-O', 'a-O', 'transmural-O', 'ECG-O', ',-O', 'in-O', 'arterially-O', 'perfused-O', 'canine-O', 'and-O', 'rabbit-O', 'left-O', 'ventricular-O', 'preparations-O', '.-O']
['dl-O', ',-O', 'Sotalol-B-Chemical', 'preferentially-O', 'prolonged-O', 'action-O', 'potential-O', 'duration-O', '(-O', 'APD-O', ')-O', 'in-O', 'M-O', 'cells-O', 'dose-O', ',-O', 'dependently-O', '(-O', '1-O', 'to-O', '100-O', 'micromol-O', '/-O', 'L-O', ')-O', 'leading-O', 'to-O', 'QT-O', 'prolongation-O', 'and-O', 'an-O', 'increase-O', 'in-O', 'TDR-O', '.-O']
['Azimilide-B-Chemical', ',-O', 'however-O', ',-O', 'significantly-O', 'prolonged-O', 'APD-O', 'and-O', 'QT-O', 'interval-O', 'at-O', 'concentrations-O', 'from-O', '0-O', '.-O']
['1-O', 'to-O', '10-O', 'micromol-O', '/-O', 'L-O', 'but-O', 'shortened-O', 'them-O', 'at-O', '30-O', 'micromol-O', '/-O', 'L-O', '.-O']
['Unlike-O', 'dl-O', ',-O', 'sotalol-B-Chemical', ',-O', 'azimilide-B-Chemical', '(>-O', '3-O', 'micromol-O', '/-O', 'L-O', ')-O', 'increased-O', 'epicardial-O', 'APD-O', 'markedly-O', ',-O', 'causing-O', 'a-O', 'diminished-O', 'TDR-O', '.-O']
['Although-O', 'both-O', 'dl-O', ',-O', 'sotalol-B-Chemical', 'and-O', 'azimilide-B-Chemical', 'rarely-O', 'induced-O', 'EADs-B-Disease', 'in-O', 'canine-O', 'left-O', 'ventricles-O', ',-O', 'they-O', 'produced-O', 'frequent-O', 'EADs-B-Disease', 'in-O', 'rabbits-O', ',-O', 'in-O', 'which-O', 'more-O', 'pronounced-O', 'QT-O', 'prolongation-I-Disease', 'was-O', 'seen-O', '.-O']
['An-O', 'increase-O', 'in-O', 'TDR-O', 'by-O', 'dl-O', ',', 'sotalol-B-Chemical', 'facilitated-O', 'transmural-O', 'propagation-O', 'of-O', 'EADs-O', 'that-O', 'initiated-O', 'multiple-O', 'episodes-O', 'of-O', 'spontaneous-O', 'TdP-B-Disease', 'in-O', '3-O', 'of-O', '6-O', 'rabbit-O', 'left-O', 'ventricles-O', '.-O']
['Of-O', 'note-O', ',-O', 'although-O', 'azimilide-B-Chemical', '(-O', '3-O', 'to-O', '10-O', 'micromol-O', '/-O', 'L-O', ')-O', 'increased-O', 'APD-O', 'more-O', 'than-O', 'dl-O', ',-O', 'sotalol-B-Chemical', ',-O', 'its-O', 'EADs-O', 'often-O', 'failed-O', 'to-O', 'propagate-O', 'transmurally-O', ',-O', 'probably-O', 'because-O', 'of-O', 'a-O', 'diminished-O', 'TDR-O', '.-O']
['CONCLUSIONS-O', ':-O', 'This-O', 'study-O', 'provides-O', 'the-O', 'first-O', 'direct-O', 'evidence-O', 'from-O', 'intracellular-O', 'action-O', 'potential-O', 'recordings-O', 'that-O', 'phase-O', '2-O', 'EAD-O', 'can-O', 'be-O', 'generated-O', 'from-O', 'intact-O', 'ventricular-O', 'wall-O', 'and-O', 'produce-O', 'a-O', 'trigger-O', 'to-O', 'initiate-O', 'the-O', 'onset-O', 'of-O', 'TdP-B-Disease', 'under-O', 'QT-O', 'prolongation-I-Disease']
['Prenatal-O', 'cocaine-B-Chemical', 'exposure-O', 'and-O', 'cranial-B-Disease', 'sonographic-O', 'findings-O', 'in-O', 'preterm-B-Disease', 'infants-O', '.-O']
['PURPOSE-O', ':-O', 'Prenatal-O', 'cocaine-B-Chemical', 'exposure-O', 'has-O', 'been-O', 'linked-O', 'with-O', 'subependymal-B-Disease', 'hemorrhage-I-Disease', 'and-O', 'the-O', 'formation-O', 'of-O', 'cysts-I-Disease', 'that-O', 'are-O', 'detectable-O', 'on-O', 'cranial-O', 'sonography-O', 'in-O', 'neonates-O', 'born-O', 'at-O', 'term-O', '.-O']
['We-O', 'sought-O', 'to-O', 'determine-O', 'if-O', 'prenatal-O', 'cocaine-B-Chemical', 'exposure-O', 'increases-O', 'the-O', 'incidence-O', 'of-O', 'subependymal-B-Disease', 'cysts-I-Disease', 'in-O', 'preterm-O', 'infants-O', '.-O']
['METHODS-O', ':-O', 'We-O', 'retrospectively-O', 'reviewed-O', 'the-O', 'medical-O', 'records-O', 'and-O', 'cranial-O', 'sonograms-O', 'obtained-O', 'during-O', 'a-O', '1-O', ',-O', 'year-O', 'period-O', 'on-O', '122-O', 'premature-O', '(-O', '<-O', '36-O', 'weeks-O', 'of-O', 'gestation)-O', 'infants-O', '.-O']
['Infants-O', 'were-O', 'categorized-O', 'into-O', '1-O', 'of-O', '2-O', 'groups-O', ':-O', 'those-O', 'exposed-O', 'to-O', 'cocaine-B-Chemical', 'and-O', 'those-O', 'not-O', 'exposed-O', 'to-O', 'cocaine-B-Chemical', '.-O']
['Infants-O', 'were-O', 'assigned-O', 'to-O', 'the-O', 'cocaine-B-Chemical', ',-O', 'exposed-O', 'group-O', 'if-O', 'there-O', 'was-O', 'a-O', 'maternal-O', 'history-O', 'of-O', 'cocaine-B-Chemical', 'abuse-I-Disease', 'during-O', 'pregnancy-O', 'or-O', 'if-O', 'maternal-O', 'or-O', 'neonatal-O', 'urine-O', 'toxicology-O', 'results-O', 'were-O', 'positive-O', 'at-O', 'the-O', 'time-O', 'of-O', 'delivery-O', '.-O']
['RESULTS-O', ':-O', 'Five-O', 'of-O', 'the-O', '122-O', 'infants-O', 'were-O', 'excluded-O', 'from-O', 'the-O', 'study-O', 'because-O', 'of-O', 'insufficient-O', 'medical-O', 'and-O', 'drug-O', 'histories-O', '.-O']
['The-O', 'incidence-O', 'of-O', 'subependymal-B-Disease', 'cysts-I-Disease', 'in-O', 'the-O', '117-O', 'remaining-O', 'infants-O', 'was-O', '14-O', '(-O', '16-O', 'of-O', '117-O', ').-O', 'The-O', 'incidence-O', 'of-O', 'subependymal-B-Disease', 'cysts-I-Disease', 'in-O', 'infants-O', 'exposed-O', 'to-O', 'cocaine-B-Chemical', 'prenatally-O', 'was-O', '44-O', '(-O', '8-O', 'of-O', '18-O', ')-O', 'compared-O', 'with-O', '8-O', '(-O', '8-O', 'of-O', '99-O', ')-O', 'in-O', 'the-O', 'unexposed-O', 'group-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'CONCLUSIONS-O', ':-O', 'We-O', 'found-O', 'an-O', 'increased-O', 'incidence-O', 'of-O', 'subependymal-B-Disease', 'cyst-B-Disease', 'formation-O', 'in-O', 'preterm-B-Disease', 'infants-O', 'who-O', 'were-O', 'exposed-O', 'to-O', 'cocaine-B-Chemical']
['Thalidomide-B-Chemical', 'neuropathy-B-Disease', 'in-O', 'patients-O', 'treated-O', 'for-O', 'metastatic-O', 'prostate-B-Disease', 'cancer-I-Disease', '.-O']
['We-O', 'prospectively-O', 'evaluated-O', 'thalidomide-B-Chemical', ',-O', 'induced-O', 'neuropathy-B-Disease', 'using-O', 'electrodiagnostic-O', 'studies-O', '.-O']
['Sixty-O', ',-O', 'seven-O', 'men-O', 'with-O', 'metastatic-O', 'androgen-O', ',-O', 'independent-O', 'prostate-B-Disease', 'cancer-I-Disease', 'in-O', 'an-O', 'open-O', ',-O', 'label-O', 'trial-O', 'of-O', 'oral-O', 'thalidomide-B-Chemical', 'underwent-O', 'neurologic-O', 'examinations-O', 'and-O', 'nerve-O', 'conduction-O', 'studies-O', '(-O', 'NCS-O', ')-O', 'prior-O', 'to-O', 'and-O', 'at-O', '3-O', ',-O', 'month-O', 'intervals-O', 'during-O', 'treatment-O', '.-O']
['NCS-O', 'included-O', 'recording-O', 'of-O', 'sensory-O', 'nerve-O', 'action-O', 'potentials-O', '(-O', 'SNAPs-O', ')-O', 'from-O', 'median-O', ',-O', 'radial-O', ',-O', 'ulnar-O', ',-O', 'and-O', 'sural-O', 'nerves-O', '.-O']
['SNAP-O', 'amplitudes-O', 'for-O', 'each-O', 'nerve-O', 'were-O', 'expressed-O', 'as-O', 'the-O', 'percentage-O', 'of-O', 'its-O', 'baseline-O', ',-O', 'and-O', 'the-O', 'mean-O', 'of-O', 'the-O', 'four-O', 'was-O', 'termed-O', 'the-O', 'SNAP-O', 'index-O', '.-O']
['A-O', '40-O', '%-O', 'decline-O', 'in-O', 'the-O', 'SNAP-O', 'index-O', 'was-O', 'considered-O', 'clinically-O', 'significant-O', '.-O']
['Thalidomide-B-Chemical', 'was-O', 'discontinued-O', 'in-O', '55-O', 'patients-O', 'for-O', 'lack-O', 'of-O', 'therapeutic-O', 'response-O', '.-O']
['Of-O', '67-O', 'patients-O', 'initially-O', 'enrolled-O', ',-O', '24-O', 'remained-O', 'on-O', 'thalidomide-B-Chemical', 'for-O', '3-O', 'months-O', ',-O', '8-O', 'remained-O', 'at-O', '6-O', 'months-O', ',-O', 'and-O', '3-O', 'remained-O', 'at-O', '9-O', 'months-O', '.-O']
['Six-O', 'patients-O', 'developed-O', 'neuropathy-B-Disease', '.-O']
['Clinical-O', 'symptoms-O', 'and-O', 'a-O', 'decline-O', 'in-O', 'the-O', 'SNAP-O', 'index-O', 'occurred-O', 'concurrently-O', '.-O']
['Older-O', 'age-O', 'and-O', 'cumulative-O', 'dose-O', 'were-O', 'possible-O', 'contributing-O', 'factors-O', '.-O']
['Neuropathy-B-Disease', 'may-O', 'thus-O', 'be-O', 'a-O', 'common-O', 'complication-O', 'of-O', 'thalidomide-B-Chemical', 'in-O', 'older-O', 'patients-O', '.-O']
['The-O', 'SNAP-O', 'index-O', 'can-O', 'be-O', 'used-O', 'to-O', 'monitor-O', 'peripheral-B-Disease', 'neuropathy-I-Disease']
['Overexpression-O', 'of-O', 'copper-B-Chemical', '/', 'zinc-B-Chemical', ',-O', 'superoxide-B-Chemical', 'dismutase-O', 'protects-O', 'from-O', 'kanamycin-B-Chemical', ',-O', 'induced-O', 'hearing-B-Disease', 'loss-I-Disease', '.-O']
['The-O', 'participation-O', 'of-O', 'reactive-O', 'oxygen-O', 'species-O', 'in-O', 'aminoglycoside-B-Chemical', ',-O', 'induced-O', 'ototoxicity-B-Disease', 'has-O', 'been-O', 'deduced-O', 'from-O', 'observations-O', 'that-O', 'aminoglycoside-B-Chemical', ',-O', 'iron-B-Chemical', 'complexes-O', 'catalyze-O', 'the-O', 'formation-O', 'of-O', 'superoxide-O', 'radicals-O', 'in-O', 'vitro-O', 'and-O', 'that-O', 'antioxidants-O', 'attenuate-O', 'ototoxicity-B-Disease', 'in-O', 'vivo-O', '.-O']
['We-O', 'therefore-O', 'hypothesized-O', 'that-O', 'overexpression-O', 'of-O', 'Cu-B-Chemical', '/', 'Zn-B-Chemical', ',-O', 'superoxide-B-Chemical', 'dismutase-O', '(-O', 'h-O', ',', 'SOD1-B-Chemical', ')-O', 'should-O', 'protect-O', 'transgenic-O', 'mice-O', 'from-O', 'ototoxicity-B-Disease', '.-O']
['Immunocytochemistry-O', 'confirmed-O', 'expression-O', 'of-O', 'h-O', ',', 'SOD1-B-Chemical', 'in-O', 'inner-O', 'ear-O', 'tissues-O', 'of-O', 'transgenic-O', 'C57BL-O', '/', '6-O', ',', 'TgN-O', '[', 'SOD1-B-Chemical', ']-O', '3Cje-O', 'mice-O', '.-O']
['Transgenic-O', 'and-O', 'nontransgenic-O', 'littermates-O', 'received-O', 'kanamycin-B-Chemical', '(-O', '400-O', 'mg-O', '/-O', 'kg-O', 'body-O', 'weight-O', '/-O', 'day-O', ')-O', 'for-O', '10-O', 'days-O', 'beginning-O', 'on-O', 'day-O', '10-O', 'after-O', 'birth-O', '.-O']
['Auditory-O', 'thresholds-O', 'were-O', 'tested-O', 'by-O', 'evoked-O', 'auditory-O', 'brain-O', 'stem-O', 'responses-O', 'at-O', '1-O', 'month-O', 'after-O', 'birth-O', '.-O']
['In-O', 'nontransgenic-O', 'animals-O', ',-O', 'the-O', 'threshold-O', 'in-O', 'the-O', 'kanamycin-B-Chemical', ',-O', 'treated-O', 'group-O', 'was-O', '45-O', ',-O', '50-O', 'dB-O', 'higher-O', 'than-O', 'in-O', 'saline-O', ',-O', 'injected-O', 'controls-O', '.-O']
['In-O', 'the-O', 'transgenic-O', 'group-O', ',-O', 'kanamycin-B-Chemical', 'increased-O', 'the-O', 'threshold-O', 'by-O', 'only-O', '15-O', 'dB-O', 'over-O', 'the-O', 'respective-O', 'controls-O', '.-O']
['The-O', 'effects-O', 'were-O', 'similar-O', 'at-O', '12-O', 'and-O', '24-O', 'kHz-O', '.-O']
['The-O', 'protection-O', 'by-O', 'overexpression-O', 'of-O', 'superoxide-B-Chemical', 'dismutase-O', 'supports-O', 'the-O', 'hypothesis-O', 'that-O', 'oxidant-O', 'stress-O', 'plays-O', 'a-O', 'significant-O', 'role-O', 'in-O', 'aminoglycoside-B-Chemical', ',-O', 'induced-O', 'ototoxicity-B-Disease']
['Prednisone-B-Chemical', 'induces-O', 'anxiety-B-Disease', 'and-O', 'glial-O', 'cerebral-O', 'changes-O', 'in-O', 'rats-O', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'assess-O', 'whether-O', 'prednisone-B-Chemical', '(-O', 'PDN-O', ')-O', 'produces-O', 'anxiety-B-Disease', 'and-O', '/-O', 'or-O', 'cerebral-O', 'glial-O', 'changes-O', 'in-O', 'rats-O', '.-O']
['METHODS-O', ':-O', 'Male-O', 'Wistar-O', 'rats-O', 'were-O', 'studied-O', 'and-O', '3-O', 'groups-O', 'were-O', 'formed-O', '(-O', '8-O', 'rats-O', 'per-O', 'group-O', ')-O', '.-O', 'The-O', 'moderate-O', ',-O', 'dose-O', 'group-O', 'received-O', '5-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', 'PDN-B-Chemical', 'released-O', 'from-O', 'a-O', 'subcutaneous-O', 'implant-O', '.-O']
['In-O', 'the-O', 'high-O', ',-O', 'dose-O', 'group-O', ',-O', 'implants-O', 'containing-O', 'PDN-B-Chemical', 'equivalent-O', 'to-O', '60-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', 'were-O', 'applied-O', '.-O']
['In-O', 'the-O', 'control-O', 'group-O', 'implants-O', 'contained-O', 'no-O', 'PDN-B-Chemical', '.-O']
['Anxiety-B-Disease', 'was-O', 'assessed-O', 'using-O', 'an-O', 'open-O', 'field-O', 'and-O', 'elevated-O', 'plus-O', ',-O', 'maze-O', 'devices-O', '.-O']
['The-O', 'number-O', 'of-O', 'cells-O', 'and-O', 'cytoplasmic-O', 'transformation-O', 'of-O', 'astrocytes-O', 'and-O', 'microglia-O', 'cells-O', 'were-O', 'assessed-O', 'by-O', 'immunohistochemical-O', 'analyses-O', '.-O']
['RESULTS-O', ':-O', 'Anxiety-B-Disease', 'was-O', 'documented-O', 'in-O', 'both-O', 'groups-O', 'of-O', 'PDN-B-Chemical', 'treated-O', 'rats-O', 'compared-O', 'with-O', 'controls-O', '.-O']
['The-O', 'magnitude-O', 'of-O', 'transformation-O', 'of-O', 'the-O', 'microglia-O', 'assessed-O', 'by-O', 'the-O', 'number-O', 'of-O', 'intersections-O', 'was-O', 'significantly-O', 'higher-O', 'in-O', 'the-O', 'PDN-B-Disease', 'groups-O', 'than-O', 'in-O', 'controls-O', 'in-O', 'the-O', 'prefrontal-O', 'cortex-O', '(-O', 'moderate-O', ',-O', 'dose-O', ',-O', '24-O', '.-O']
['1-O', ';-O', 'high-O', ',-O', 'dose-O', ',-O', '23-O', '.-O']
['6-O', ';-O', 'controls-O', '18-O', '.-O']
['7-O', ';-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'and-O', 'striatum-O', '(-O', 'moderate-O', ',-O', 'dose-O', '25-O', '.-O']
['6-O', ';-O', 'high-O', ',-O', 'dose-O', '26-O', '.-O']
['3-O', ';-O', 'controls-O', '18-O', '.-O']
['9-O', ';-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'but-O', 'not-O', 'in-O', 'hippocampus-O', '.-O']
['The-O', 'number-O', 'of-O', 'stained-O', 'microglia-O', 'cells-O', 'was-O', 'significantly-O', 'higher-O', 'in-O', 'the-O', 'PDN-B-Chemical', 'treated-O', 'groups-O', 'in-O', 'the-O', 'prefrontal-O', 'cortex-O', 'than-O', 'in-O', 'controls-O', '(-O', 'moderate-O', ',-O', 'dose-O', ',-O', '29-O', '.-O']
['1-O', ';-O', 'high-O', ',-O', 'dose-O', ',-O', '28-O', '.-O']
['4-O', ';-O', 'control-O', ',-O', '17-O', '.-O']
['7-O', 'cells-O', 'per-O', 'field-O', ';-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'Stained-O', 'microglia-O', 'cells-O', 'were-O', 'significantly-O', 'more-O', 'numerous-O', 'striatum-O', 'and-O', 'hippocampus-O', 'in-O', 'the-O', 'high-O', ',-O', 'dose-O', 'group-O', 'compared-O', 'to-O', 'controls-O', '.-O']
['CONCLUSION-O', ':-O', 'Subacute-O', 'exposure-O', 'to-O', 'PDN-B-Chemical', 'induced-O', 'anxiety-B-Disease', 'and-O', 'reactivity-O', 'of-O', 'microglia-O', '.-O']
['The-O', 'relevance-O', 'of-O', 'these-O', 'features-O', 'for-O', 'patients-O', 'using-O', 'PDN-B-Chemical']
['Phase-O', 'II-O', 'study-O', 'of-O', 'carboplatin-B-Chemical', 'and-O', 'liposomal-O', 'doxorubicin-B-Chemical', 'in-O', 'patients-O', 'with-O', 'recurrent-O', 'squamous-B-Disease', 'cell-I-Disease', 'carcinoma-I-Disease', 'of-O', 'the-O', 'cervix-I-Disease', '.-O']
['BACKGROUND-O', ':-O', 'The-O', 'activity-O', 'of-O', 'the-O', 'combination-O', 'of-O', 'carboplatin-B-Chemical', 'and-O', 'liposomal-O', 'doxorubicin-B-Chemical', 'was-O', 'tested-O', 'in-O', 'a-O', 'Phase-O', 'II-O', 'study-O', 'of-O', 'patients-O', 'with-O', 'recurrent-O', 'cervical-B-Disease', 'carcinoma-I-Disease', '.-O']
['METHODS-O', ':', 'The-O', 'combination-O', 'of-O', 'carboplatin-B-Chemical', '(-O', 'area-O', 'under-O', 'the-O', 'concentration-O', 'curve-O', '[', 'AUC-O', ']-O', '5-O', ')-O', 'and-O', 'liposomal-O', 'doxorubicin-B-Chemical', '(-O', 'Doxil-O', ';-O', 'starting-O', 'dose-O', ',-O', '40-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', '))-O', 'was-O', 'administered-O', 'intravenously-O', 'every-O', '28-O', 'days-O', 'to-O', '37-O', 'patients-O', 'with-O', 'recurrent-O', 'squamous-B-Disease', 'cell-I-Disease', 'cervical-I-Disease', 'carcinoma-I-Disease', 'to-O', 'determine-O', 'antitumor-O', 'activity-O', 'and-O', 'toxicity-B-Disease', 'profile-O', '.-O']
['RESULTS-O', ':-O', 'Twenty-O', ',-O', 'nine-O', 'patients-O', 'were-O', 'assessable-O', 'for-O', 'response-O', ',-O', 'and-O', '35-O', 'patients-O', 'were-O', 'assessable-O', 'for-O', 'toxicity-B-Disease', '.-O']
['The-O', 'overall-O', 'response-O', 'rate-O', 'was-O', '38-O', ',-O', 'the-O', 'median-O', 'time-O', 'to-O', 'response-O', 'was-O', '10-O', 'weeks-O', ',-O', 'the-O', 'median-O', 'duration-O', 'of-O', 'response-O', 'was-O', '26-O', 'weeks-O', ',-O', 'and-O', 'the-O', 'median-O', 'survival-O', 'was-O', '37-O', 'weeks-O', '.-O']
['The-O', 'main-O', 'toxic-O', 'effect-O', 'was-O', 'myelosuppression-B-Disease', ',', 'with-O', 'Grade-O', '3-O', 'and-O', '4-O', 'neutropenia-B-Disease', 'in-O', '16-O', 'patients-O', ',', 'anemia-B-Disease', 'in-O', '12-O', 'patients-O', ',', 'thrombocytopenia-B-Disease', 'in-O', '11-O', 'patients-O', ',', 'and-O', 'neutropenic-O', 'fever-B-Disease', 'in-O', '3-O', 'patients-O', '.-O']
['Four-O', 'patients-O', 'had-O', 'five-O', 'infusion-O', ',-O', 'related-O', 'reactions-O', 'during-O', 'the-O', 'infusion-O', 'of-O', 'liposomal-O', 'doxorubicin-B-Chemical', ',-O', 'leading-O', 'to-O', 'treatment-O', 'discontinuation-O', 'in-O', 'three-O', 'patients-O', '.-O']
['Grade-O', '>-O', 'or-O', '=-O', '2-O', 'nonhematologic-O', 'toxicity-O', 'included-O', 'nausea-B-Disease', 'in-O', '17-O', 'patients-O', ',-O', 'emesis-B-Disease', 'in-O', '14-O', 'patients-O', ',-O', 'fatigue-B-Disease', 'in-O', '9-O', 'patients-O', ',-O', 'mucositis-B-Disease', 'and-O', '/-O', 'or-O', 'stomatitis-B-Disease', 'in-O', '8-O', 'patients-O', ',-O', 'constipation-B-Disease', 'in-O', '6-O', 'patients-O', ',-O', 'weight-O', 'loss-B-Disease', 'in-O', '5-O', 'patients-O', ',-O', 'hand-foot-B-Disease', 'syndrome-I-Disease', 'in-O', '2-O', 'patients-O', ',-O', 'and-O', 'skin-O', 'reactions-B-Disease', 'in-O', '3-O', 'patients-O', '.-O']
['CONCLUSIONS-O', ':-O', 'The-O', 'combination-O', 'of-O', 'carboplatin-B-Chemical', 'and-O', 'liposomal-O', 'doxorubicin-B-Chemical', 'has-O', 'modest-O', 'activity-O', 'in-O', 'patients-O', 'with-O', 'recurrent-O', 'cervical-O', 'carcinoma-B-Disease']
['Antimicrobial-O', ',-O', 'induced-O', 'mania-B-Disease', '(-O', 'antibiomania-I-Disease', '):-O', 'a-O', 'review-O', 'of-O', 'spontaneous-O', 'reports-O', '.-O']
['The-O', 'authors-O', 'reviewed-O', 'reported-O', 'cases-O', 'of-O', 'antibiotic-O', ',-O', 'induced-O', 'manic-B-Disease', 'episodes-O', 'by-O', 'means-O', 'of-O', 'a-O', 'MEDLINE-O', 'and-O', 'PsychLit-O', 'search-O', 'for-O', 'reports-O', 'of-O', 'antibiotic-O', ',-O', 'induced-O', 'mania-B-Disease', '.-O']
['Unpublished-O', 'reports-O', 'were-O', 'requested-O', 'from-O', 'the-O', 'World-O', 'Health-O', 'Organization-O', '(-O', 'WHO-O', ')-O', 'and-O', 'the-O', 'Food-O', 'and-O', 'Drug-O', 'Administration-O', '(-O', 'FDA-O', ')-O', '.', 'Twenty-O', ',-O', 'one-O', 'reports-O', 'of-O', 'antimicrobial-O', ',-O', 'induced-O', 'mania-B-Disease', 'were-O', 'found-O', 'in-O', 'the-O', 'literature-O', '.-O']
['There-O', 'were-O', '6-O', 'cases-O', 'implicating-O', 'clarithromycin-B-Chemical', ',-O', '13-O', 'implicating-O', 'isoniazid-B-Chemical', ',-O', 'and-O', '1-O', 'case-O', 'each-O', 'implicating-O', 'erythromycin-B-Chemical', 'and-O', 'amoxicillin-B-Chemical', '.-O']
['The-O', 'WHO-O', 'reported-O', '82-O', 'cases-O', '.-O']
['Of-O', 'these-O', ',-O', 'clarithromycin-B-Chemical', 'was-O', 'implicated-O', 'in-O', '23-O', '(-O', '27-O', '.-O']
['6-O', ')-O', 'cases-O', ',-O', 'ciprofloxacin-B-Chemical', 'in-O', '12-O', '(-O', '14-O', '.-O']
['4-O', ')-O', 'cases-O', ',-O', 'and-O', 'ofloxacin-B-Chemical', 'in-O', '10-O', '(-O', '12-O', ')-O', 'cases-O', '.-O']
['Cotrimoxazole-B-Chemical', ',-O', 'metronidazole-B-Chemical', ',-O', 'and-O', 'erythromycin-B-Chemical', 'were-O', 'involved-O', 'in-O', '15-O', 'reported-O', 'manic-B-Disease', 'episodes-O', '.-O']
['Cases-O', 'reported-O', 'by-O', 'the-O', 'FDA-O', 'showed-O', 'clarithromycin-B-Chemical', 'and-O', 'ciprofloxacin-B-Chemical', 'to-O', 'be-O', 'the-O', 'most-O', 'frequently-O', 'associated-O', 'with-O', 'the-O', 'development-O', 'of-O', 'mania-B-Disease', '.-O']
['Statistical-O', 'analysis-O', 'of-O', 'the-O', 'data-O', 'would-O', 'not-O', 'have-O', 'demonstrated-O', 'a-O', 'significant-O', 'statistical-O', 'correlative-O', 'risk-O', 'and-O', 'was-O', 'therefore-O', 'not-O', 'undertaken-O', '.-O']
['Patients-O', 'have-O', 'an-O', 'increased-O', 'risk-O', 'of-O', 'developing-O', 'mania-B-Disease', 'while-O', 'being-O', 'treated-O', 'with-O', 'antimicrobials-B-Chemical', '.-O']
['Although-O', 'this-O', 'is-O', 'not-O', 'a-O', 'statistically-O', 'significant-O', 'risk-O', ',-O', 'physicians-O', 'must-O', 'be-O', 'aware-O', 'of-O', 'the-O', 'effect-O', 'and-O', 'reversibility-O', '.-O']
['Further-O', 'research-O', 'clearly-O', 'is-O', 'required-O', 'to-O', 'determine-O', 'the-O', 'incidence-O', 'of-O', 'antimicrobial-B-Chemical', '--O', 'induced-O', 'mania-B-Disease', '--O', 'the-O', 'relative-O', 'risk-O', 'factors-O', 'of-O', 'developing-O', 'an-O', 'antimicrobial-B-Chemical', '--O', 'induced-O', 'manic-O', 'episode-O', 'among-O', 'various-O', 'demographic-O', 'populations-O', '--O', 'and-O', 'the-O', 'incidence-O', 'of-O', 'patients-O', 'who-O', 'continue-O', 'to-O', 'have-O', 'persistent-O', 'affective-O', 'disorders-O', 'once-O', 'the-O', 'initial-O', 'episode-O', '--O', 'which-O', 'occurs-O', 'while-O', 'the-O', 'patient-O', 'is-O', 'taking-O', 'antibiotics-B-Chemical', '--O', 'subsides-O', '.-O']
['The-O', 'authors-O', 'elected-O', 'to-O', 'name-O', 'this-O', 'syndrome-O', 'x-O', 'antibiomania-B-Disease', '.-O']
['Levodopa-B-Chemical', ',-O', 'induced-O', 'ocular-O', 'dyskinesias-B-Disease', 'in-O', 'Parkinson-B-Disease', 'disease-I-Disease', '.-O']
['Levodopa-B-Chemical', ',-O', 'induced-O', 'ocular-O', 'dyskinesias-B-Disease', 'are-O', 'very-O', 'uncommon-O', '.-O']
['Usually-O', 'they-O', 'occur-O', 'simultaneously-O', 'with-O', 'limb-O', 'peak-O', ',-O', 'dose-O', 'choreatic-B-Disease', 'dyskinesias-B-Disease', '.-O']
['We-O', 'report-O', 'on-O', 'a-O', 'patient-O', 'with-O', 'leftward-O', 'and-O', 'upward-O', 'deviations-O', 'of-O', 'gaze-O', 'during-O', 'the-O', 'peak-O', 'effect-O', 'of-O', 'levodopa-B-Chemical', ',-O', 'and-O', 'hypothesize-O', 'that-O', 'a-O', 'severe-O', 'dopaminergic-O', 'denervation-O', 'in-O', 'the-O', 'caudate-O', 'nucleus-O', 'is-O', 'needed-O', 'for-O', 'the-O', 'appearance-O', 'of-O', 'these-O', 'levodopa-B-Chemical', ',-O', 'induce-O', 'ocular-O', 'dyskinesias-B-Disease']
['A-O', 'comparison-O', 'of-O', 'glyceryl-B-Chemical', 'trinitrate-B-Chemical', 'with-O', 'diclofenac-B-Chemical', 'for-O', 'the-O', 'treatment-O', 'of-O', 'primary-O', 'dysmenorrhea-B-Disease', ':-O', 'an-O', 'open-O', ',-O', 'randomized-O', ',-O', 'cross-O', ',-O', 'over-O', 'trial-O', '.-O']
['Primary-O', 'dysmenorrhea-B-Disease', 'is-O', 'a-O', 'syndrome-O', 'characterized-O', 'by-O', 'painful-O', 'uterine-O', 'contractility-O', 'caused-O', 'by-O', 'a-O', 'hypersecretion-O', 'of-O', 'endometrial-O', 'prostaglandins-B-Chemical', ';-O', 'non-O', ',-O', 'steroidal-O', 'anti-O', '--O', 'inflammatory-O', 'drugs-O', 'are-O', 'the-O', 'first-O', 'choice-O', 'for-O', 'its-O', 'treatment-O', '.-O']
['However-O', ',-O', 'in-O', 'vivo-O', 'and-O', 'in-O', 'vitro-O', 'studies-O', 'have-O', 'demonstrated-O', 'that-O', 'myometrial-O', 'cells-O', 'are-O', 'also-O', 'targets-O', 'of-O', 'the-O', 'relaxant-O', 'effects-O', 'of-O', 'nitric-O', 'oxide-B-Chemical', '(-O', 'NO-B-Chemical', ')-O', '.-O', 'The-O', 'aim-O', 'of-O', 'the-O', 'present-O', 'study-O', 'was-O', 'to-O', 'determine-O', 'the-O', 'efficacy-O', 'of-O', 'glyceryl-O', 'trinitrate-B-Chemical', '(-O', 'GTN-B-Chemical', ')-O', ',', 'an-O', 'NO-B-Chemical', 'donor-O', ',-O', 'in-O', 'the-O', 'resolution-O', 'of-O', 'primary-O', 'dysmenorrhea-B-Disease', 'in-O', 'comparison-O', 'with-O', 'diclofenac-B-Chemical', '(-O', 'DCF-B-Chemical', ')-O', '.-O', 'A-O', 'total-O', 'of-O', '24-O', 'patients-O', 'with-O', 'the-O', 'diagnosis-O', 'of-O', 'severe-O', 'primary-O', 'dysmenorrhea-B-Disease', 'were-O', 'studied-O', 'during-O', 'two-O', 'consecutive-O', 'menstrual-O', 'cycles-O', '.-O']
['In-O', 'an-O', 'open-O', ',-O', 'cross-O', ',-O', 'over-O', ',-O', 'controlled-O', 'design-O', ',-O', 'patients-O', 'were-O', 'randomized-O', 'to-O', 'receive-O', 'either-O', 'DCF-B-Chemical', 'per-O', 'os-O', 'or-O', 'GTN-B-Chemical', 'patches-O', 'the-O', 'first-O', 'days-O', 'of-O', 'menses-O', ',-O', 'when-O', 'menstrual-O', 'cramps-O', 'became-O', 'unendurable-O', '.-O']
['In-O', 'the-O', 'subsequent-O', 'cycle-O', 'the-O', 'other-O', 'treatment-O', 'was-O', 'used-O', '.-O']
['Patients-O', 'received-O', 'up-O', 'to-O', '3-O', 'doses-O', '/-O', 'day-O', 'of-O', '50-O', 'mg-O', 'DCF-B-Chemical', 'or-O', '2-O', '.-O']
['5-O', 'mg-O', '/-O', '24-O', 'h-O', 'transdermal-O', 'GTN-B-Chemical', 'for-O', 'the-O', 'first-O', '3-O', 'days-O', 'of-O', 'the-O', 'cycle-O', ',-O', 'according-O', 'to-O', 'their-O', 'needs-O', '.-O']
['The-O', 'participants-O', 'recorded-O', 'menstrual-O', 'symptoms-O', 'and-O', 'possible-O', 'side-O', ',-O', 'effects-O', 'at-O', 'different-O', 'times-O', '(-O', '0-O', ',-O', '30-O', ',-O', '60-O', ',-O', '120-O', 'minutes-O', ')-O', 'after-O', 'the-O', 'first-O', 'dose-O', 'of-O', 'medication-O', 'on-O', 'the-O', 'first-O', 'day-O', 'of-O', 'the-O', 'cycle-O', ',-O', 'with-O', 'both-O', 'drugs-O', '.-O']
['The-O', 'difference-O', 'in-O', 'pain-B-Disease', 'intensity-O', 'score-O', '(-O', 'DPI-O', ')-O', 'was-O', 'the-O', 'main-O', 'outcome-O', 'variable-O', '.-O']
['Both-O', 'treatments-O', 'significantly-O', 'reduced-O', 'DPI-O', 'by-O', 'the-O', '30th-O', 'minute-O', '(-O', 'GTN-B-Chemical', ',-O', '12-O', '.-O']
['8-O', '+-O', '17-O', '.-O']
['9-O', ';-O', 'DCF-O', ',-O', '18-O', '.-O']
['9-O', '+-O', '16-O', '.-O']
['6-O', ').-O', 'However-O', ',-O', 'DCF-B-Chemical', 'continued-O', 'to-O', 'be-O', 'effective-O', 'in-O', 'reducing-O', 'pelvic-B-Disease', 'pain-B-Disease', 'for-O', 'two-O', 'hours-O', ',-O', 'whereas-O', 'GTN-B-Chemical', 'scores-O', 'remained-O', 'more-O', 'or-O', 'less-O', 'stable-O', 'after-O', '30-O', 'min-O', 'and-O', 'significantly-O', 'higher-O', 'than-O', 'those-O', 'for-O', 'DFC-B-Chemical', '(-O', 'after-O', 'one-O', 'hour-O', ':-O', 'GTN-O', ',-O', '12-O', '.-O']
['8-O', '+-O', '17-O', '.-O']
['9-O', ';-O', 'DFC-O', ',-O', '18-O', '.-O']
['9-O', '+-O', '16-O', '.-O']
['6-O', 'and-O', 'after-O', 'two-O', 'hours-O', ':-O', 'GTN-B-Chemical', ',-O', '23-O', '.-O']
['7-O', '+-O', '20-O', '.-O']
['5-O', ';-O', 'DFC-O', ',-O', '59-O', '.-O']
['7-O', '+-O', '17-O', '.-O']
['9-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['0001-O', ').-O', 'Low-O', 'back-O', 'pain-B-Disease', 'was-O', 'also-O', 'relieved-O', 'by-O', 'both-O', 'drugs-O', '.-O']
['Headache-B-Disease', 'was-O', 'significantly-O', 'increased-O', 'by-O', 'GTN-B-Chemical', 'but-O', 'not-O', 'by-O', 'DCF-B-Chemical', '.-O']
['Eight-O', 'patients-O', 'stopped-O', 'using-O', 'GTN-B-Chemical', 'because-O', 'headache-B-Disease', '--O', 'attributed-O', 'to-O', 'its-O', 'use-O', '--O', 'became-O', 'intolerable-O', '.-O']
['These-O', 'findings-O', 'indicate-O', 'that-O', 'GTN-B-Chemical', 'has-O', 'a-O', 'reduced-O', 'efficacy-O', 'and-O', 'tolerability-O', 'by-O', 'comparison-O', 'with-O', 'DCF-B-Chemical', 'in-O', 'the-O', 'treatment-O', 'of-O', 'primary-O', 'dysmenorrhea-B-Disease']
['Temocapril-B-Chemical', ',-O', 'a-O', 'long-O', ',-O', 'acting-O', 'non-O', ',-O', 'SH-O', 'group-O', 'angiotensin-B-Chemical', 'converting-O', 'enzyme-O', 'inhibitor-O', ',-O', 'modulates-O', 'glomerular-O', 'injury-O', 'in-O', 'chronic-O', 'puromycin-B-Chemical', 'aminonucleoside-I-Chemical', 'nephrosis-B-Disease', '.-O']
['The-O', 'purpose-O', 'of-O', 'the-O', 'present-O', 'study-O', 'was-O', 'to-O', 'determine-O', 'whether-O', 'chronic-O', 'administration-O', 'of-O', 'temocapril-B-Chemical', ',-O', 'a-O', 'long-O', ',-O', 'acting-O', 'non-O', ',-O', 'SH-O', 'group-O', 'angiotensin-B-Chemical', 'converting-O', 'enzyme-O', '(-O', 'ACE-O', ')-O', 'inhibitor-O', ',-O', 'reduced-O', 'proteinuria-B-Disease', ',-O', 'inhibited-O', 'glomerular-O', 'hypertrophy-O', 'and-O', 'prevented-O', 'glomerulosclerosis-B-Disease', 'in-O', 'chronic-O', 'puromycin-B-Chemical', 'aminonucleoside-I-Chemical', '(-O', 'PAN-B-Chemical', ')-O', 'induced-O', 'nephrotic-B-Disease', 'rats-O', '.-O']
['Nephrosis-B-Disease', 'was-O', 'induced-O', 'by-O', 'injection-O', 'of-O', 'PAN-B-Chemical', '(-O', '15mg-O', '/-O', '100g-O', 'body-O', 'weight-O', ')-O', 'in-O', 'male-O', 'Sprague-O', ',-O', 'Dawley-O', '(-O', 'SD-O', ')-O', 'rats-O', '.-O']
['Four-O', 'groups-O', 'were-O', 'used-O', ',-O', 'i-O', ')-O', 'the-O', 'PAN-B-Chemical', 'group-O', '(-O', '14-O', ')-O', ',-O', 'ii-O', ')-O', 'PAN-B-Chemical', '/-O', 'temocapril-B-Chemical', '(-O', '13-O', ')-O', ',-O', 'iii-O', ')-O', 'temocapril-B-Chemical', '(-O', '14-O', ')-O', 'and-O', 'iv-O', ')-O', 'untreated-O', 'controls-O', '(-O', '15-O', ').-O', 'Temocapril-B-Chemical', '(-O', '8-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', ')-O', 'was-O', 'administered-O', 'to-O', 'the-O', 'rats-O', 'which-O', 'were-O', 'killed-O', 'at-O', 'weeks-O', '4-O', ',-O', '14-O', 'or-O', '20-O', '.-O']
['At-O', 'each-O', 'time-O', 'point-O', ',-O', 'systolic-O', 'blood-O', 'pressure-O', '(-O', 'BP-O', ')-O', ',-O', 'urinary-O', 'protein-O', 'excretion-O', 'and-O', 'renal-O', 'histopathological-O', 'findings-O', 'were-O', 'evaluated-O', ',-O', 'and-O', 'morphometric-O', 'image-O', 'analysis-O', 'was-O', 'done-O', '.-O']
['Systolic-O', 'BP-O', 'in-O', 'the-O', 'PAN-B-Chemical', 'group-O', 'was-O', 'significantly-O', 'high-O', 'at-O', '4-O', ',-O', '14-O', 'and-O', '20-O', 'weeks-O', ',-O', 'but-O', 'was-O', 'normal-O', 'in-O', 'the-O', 'PAN-B-Chemical', '/-O', 'temocapril-B-Chemical', 'group-O', '.-O']
['Urinary-O', 'protein-O', 'excretion-O', 'in-O', 'the-O', 'PAN-B-Chemical', 'group-O', 'increased-O', 'significantly-O', ',-O', 'peaking-O', 'at-O', '8-O', 'days-O', ',-O', 'then-O', 'decreased-O', 'at-O', '4-O', 'weeks-O', ',-O', 'but-O', 'rose-O', 'again-O', 'significantly-O', 'at-O', '14-O', 'and-O', '20-O', 'weeks-O', '.-O']
['Temocapril-B-Chemical', 'did-O', 'not-O', 'attenuate-O', 'proteinuria-B-Disease', 'at-O', '8-O', 'days-O', ',-O', 'but-O', 'it-O', 'did-O', 'markedly-O', 'lower-O', 'it-O', 'from-O', 'weeks-O', '4-O', 'to-O', '20-O', '.-O']
['The-O', 'glomerulosclerosis-B-Disease', 'index-O', '(-O', 'GSI-O', ')-O', 'was-O', '6-O', '.-O']
['21-O', '%-O', 'at-O', '4-O', 'weeks-O', 'and-O', 'respectively-O', '25-O', '.-O']
['35-O', '%-O', 'and-O', '30-O', '.-O']
['49-O', '%-O', 'at-O', '14-O', 'and-O', '20-O', 'weeks-O', 'in-O', 'the-O', 'PAN-B-Chemical', 'group-O', '.-O']
['There-O', 'was-O', 'a-O', 'significant-O', 'correlation-O', 'between-O', 'urinary-O', 'protein-O', 'excretion-O', 'and-O', 'GSI-O', '(-O', 'r-O', '=-O', '0-O', '.-O']
['808-O', ',-O', 'p-O', '<-O', '0-O', '.-O']
['0001-O', ').-O', 'The-O', 'ratio-O', 'of-O', 'glomerular-O', 'tuft-O', 'area-O', 'to-O', 'the-O', 'area-O', 'of-O', 'Bowman-O', 'x-O', 's-O', 'capsules-O', '(-O', 'GT-O', '/-O', 'BC-O', ')-O', 'in-O', 'the-O', 'PAN-B-Chemical', 'group-O', 'was-O', 'significantly-O', 'increased-O', ',-O', 'but-O', 'it-O', 'was-O', 'significantly-O', 'lower-O', 'in-O', 'the-O', 'PAN-B-Chemical', '/-O', 'temocapril-B-Chemical', 'group-O', '.-O']
['It-O', 'appears-O', 'that-O', 'temocapril-B-Chemical', 'was-O', 'effective-O', 'in-O', 'retarding-O', 'renal-O', 'progression-O', 'and-O', 'protected-O', 'renal-O', 'function-O', 'in-O', 'PAN-B-Chemical', 'neprotic-O']
['Pulmonary-B-Disease', 'hypertension-I-Disease', 'after-O', 'ibuprofen-B-Chemical', 'prophylaxis-O', 'in-O', 'very-O', 'preterm-O', 'infants-O', '.-O']
['We-O', 'report-O', 'three-O', 'cases-O', 'of-O', 'severe-O', 'hypoxaemia-B-Disease', 'after-O', 'ibuprofen-B-Chemical', 'administration-O', 'during-O', 'a-O', 'randomised-O', 'controlled-O', 'trial-O', 'of-O', 'prophylactic-O', 'treatment-O', 'of-O', 'patent-O', 'ductus-O', 'arteriosus-B-Disease', 'with-O', 'ibuprofen-B-Chemical', 'in-O', 'premature-O', 'infants-O', 'born-O', 'at-O', 'less-O', 'than-O', '28-O', 'weeks-O', 'of-O', 'gestation-O', '.-O']
['Echocardiography-O', 'showed-O', 'severely-O', 'decreased-O', 'pulmonary-O', 'blood-O', 'flow-O', '.-O']
['Hypoxaemia-B-Disease', 'resolved-O', 'quickly-O', 'on-O', 'inhaled-O', 'nitric-B-Chemical', 'oxide-I-Chemical', 'therapy-O', '.-O']
['We-O', 'suggest-O', 'that-O', 'investigators-O', 'involved-O', 'in-O', 'similar-O', 'trials-O', 'pay-O', 'close-O', 'attention-O', 'to-O', 'pulmonary-O', 'pressure-O', 'if-O', 'hypoxaemia-B-Disease', 'occurs-O', 'after-O', 'prophylactic-O', 'administration-O', 'of-O', 'ibuprofen-B-Chemical']
['Hyponatremia-B-Disease', 'and-O', 'syndrome-O', 'of-O', 'inappropriate-O', 'anti-diuretic-O', 'hormone-O', 'reported-O', 'with-O', 'the-O', 'use-O', 'of-O', 'Vincristine-B-Chemical', ':-O', 'an-O', 'over-O', ',-O', 'representation-O', 'of-O', 'Asians-O', '?-O', 'PURPOSE-O', ':-O', 'This-O', 'retrospective-O', 'study-O', 'used-O', 'a-O', 'pharmaceutical-O', 'company-O', 'x-O', 's-O', 'global-O', 'safety-O', 'database-O', 'to-O', 'determine-O', 'the-O', 'reporting-O', 'rate-O', 'of-O', 'hyponatremia-B-Disease', 'and-O', '/-O', 'or-O', 'syndrome-O', 'of-O', 'inappropriate-O', 'secretion-O', 'of-O', 'anti-diuretic-O', 'hormone-O', '(-O', 'SIADH-B-Disease', ')-O', 'among-O', 'vincristine-B-Chemical', '-O', 'treated-O', 'patients-O', 'and-O', 'to-O', 'explore-O', 'the-O', 'possibility-O', 'of-O', 'at-O', '-O', 'risk-O', 'population-O', 'subgroups-O', '.-O']
['METHOD-O', ':-O', 'We-O', 'searched-O', 'the-O', 'Eli-O', 'Lilly-O', 'and-O', 'Company-O', 'x-O', 's-O', 'computerized-O', 'adverse-O', 'event-O', 'database-O', 'for-O', 'all-O', 'reported-O', 'cases-O', 'of-O', 'hyponatremia-B-Disease', 'and-O', '/-O', 'or-O', 'SIADH-B-Disease', 'as-O', 'of-O', '1-O', 'November-O', '1999-O', 'that-O', 'had-O', 'been-O', 'reported-O', 'during-O', 'the-O', 'use-O', 'of-O', 'vincristine-B-Chemical', '.-O']
['RESULTS-O', ':-O', 'A-O', 'total-O', 'of-O', '76-O', 'cases-O', 'of-O', 'hyponatremia-B-Disease', 'and-O', '/-O', 'or-O', 'SIADH-B-Disease', 'associated-O', 'with-O', 'vincristine-B-Chemical', 'use-O', 'were-O', 'identified-O', '.-O']
['The-O', 'overall-O', 'reporting-O', 'rate-O', 'was-O', 'estimated-O', 'to-O', 'be-O', '1-O', '.-O']
['3-O', '/-O', '100-O', ',-O', '000-O', 'treated-O', 'patients-O', '.-O']
['The-O', 'average-O', 'age-O', 'of-O', 'patients-O', 'was-O', '35-O', '.-O']
['6-O', '+-O', '28-O', '.-O']
['3-O', 'years-O', ',-O', 'and-O', '62-O', '%-O', 'were-O', 'males-O', '.-O']
['Approximately-O', '75-O', '%-O', 'of-O', 'the-O', 'patients-O', 'were-O', 'receiving-O', 'treatment-O', 'for-O', 'leukemia-B-Disease', 'or-O', 'lymphoma-B-Disease', '.-O']
['Among-O', 'the-O', '39-O', 'reports-O', 'that-O', 'included-O', 'information-O', 'on-O', 'race-O', ',-O', 'the-O', 'racial-O', 'distribution-O', 'was-O', ':-O', '1-O', 'Black-O', ',-O', '3-O', 'Caucasian-O', ',-O', 'and-O', '35-O', 'Asian-O', '.-O']
['CONCLUSION-O', ':-O', 'Our-O', 'data-O', 'suggest-O', 'that-O', 'Asian-O', 'patients-O', 'may-O', 'be-O', 'at-O', 'increased-O', 'risk-O', 'of-O', 'hyponatremia-B-Disease', 'and-O', '/-O', 'or-O', 'SIADH-B-Disease', 'associated-O', 'with-O', 'vincristine-B-Chemical', 'use-O', '.-O']
['Although-O', 'the-O', 'overall-O', 'reported-O', 'rate-O', 'of-O', 'SIADH-B-Disease', 'associated-O', 'with-O', 'vincristine-B-Chemical']
['Delayed-O', 'toxicity-O', 'of-O', 'cyclophosphamide-B-Chemical', 'on-O', 'the-O', 'bladder-B-Disease', 'of-O', 'DBA-O', '/-O', '2-O', 'and-O', 'C57BL-O', '/-O', '6-O', 'female-O', 'mouse-O', '.-O']
['The-O', 'present-O', 'study-O', 'describes-O', 'the-O', 'delayed-O', 'development-O', 'of-O', 'a-O', 'severe-O', 'bladder-B-Disease', 'pathology-O', 'in-O', 'a-O', 'susceptible-O', 'strain-O', 'of-O', 'mice-O', '(-O', 'DBA-O', '/-O', '2-O', ')-O', 'but-O', 'not-O', 'in-O', 'a-O', 'resistant-O', 'strain-O', '(-O', 'C57BL-O', '/-O', '6-O', ')-O', 'when-O', 'both-O', 'were-O', 'treated-O', 'with-O', 'a-O', 'single-O', '300-O', 'mg-O', '/-O', 'kg-O', 'dose-O', 'of-O', 'cyclophosphamide-B-Chemical', '(-O', 'CY-B-Chemical', ')-O', '.-O', 'Inbred-O', 'DBA-O', '/-O', '2-O', 'and-O', 'C57BL-O', '/-O', '6-O', 'female-O', 'mice-O', 'were-O', 'injected-O', 'with-O', 'CY-B-Chemical', ',-O', 'and-O', 'the-O', 'effect-O', 'of-O', 'the-O', 'drug-O', 'on-O', 'the-O', 'bladder-O', 'was-O', 'assessed-O', 'during-O', '100-O', 'days-O', 'by-O', 'light-O', 'microscopy-O', 'using-O', 'different-O', 'staining-O', 'procedures-O', ',-O', 'and-O', 'after-O', '30-O', 'days-O', 'by-O', 'conventional-O', 'electron-O', 'microscopy-O', '.-O']
['Early-O', 'CY-B-Chemical', 'toxicity-O', 'caused-O', 'a-O', 'typical-O', 'haemorrhagic-B-Disease', 'cystitis-I-Disease', 'in-O', 'both-O', 'strains-O', 'that-O', 'was-O', 'completely-O', 'repaired-O', 'in-O', 'about-O', '7-O', ',', '10-O', 'days-O', '.-O']
['After-O', '30-O', 'days-O', 'of-O', 'CY-B-Chemical', 'injection-O', 'ulcerous-O', 'and-O', 'non-O', ',-O', 'ulcerous-O', 'forms-O', 'of-O', 'chronic-B-Disease', 'cystitis-B-Disease', 'appeared-O', 'in-O', '86-O', '%-O', 'of-O', 'DBA-O', '/-O', '2-O', 'mice-O', 'but-O', 'only-O', 'in-O', '4-O', '%-O', 'of-O', 'C57BL-O', '/-O', '6-O', 'mice-O', '.-O']
['Delayed-O', 'cystitis-B-Disease', 'was-O', 'characterized-O', 'by-O', 'infiltration-O', 'and-O', 'transepithelial-O', 'passage-O', 'into-O', 'the-O', 'lumen-O', 'of-O', 'inflammatory-O', 'cells-O', 'and-O', 'by-O', 'frequent-O', 'exfoliation-O', 'of-O', 'the-O', 'urothelium-O', '.-O']
['Mast-O', 'cells-O', 'appeared-O', 'in-O', 'the-O', 'connective-O', 'and-O', 'muscular-O', 'layers-O', 'of-O', 'the-O', 'bladder-O', 'at-O', 'a-O', 'much-O', 'higher-O', 'number-O', 'in-O', 'DBA-O', '/-O', '2-O', 'mice-O', 'than-O', 'in-O', 'C57BL-O', '/-O', '6-O', 'mice-O', 'or-O', 'untreated-O', 'controls-O', '.-O']
['Electron-O', 'microscopy-O', 'disclosed-O', 'the-O', 'absence-O', 'of-O', 'the-O', 'typical-O', 'discoidal-O', 'vesicles-O', 'normally-O', 'present-O', 'in-O', 'the-O', 'cytoplasm-O', 'of-O', 'surface-O', 'cells-O', '.-O']
['Instead-O', ',-O', 'numerous-O', 'abnormal-O', 'vesicles-O', 'containing-O', 'one-O', 'or-O', 'several-O', 'dark-O', 'granules-O', 'were-O', 'observed-O', 'in-O', 'the-O', 'cytoplasm-O', 'of-O', 'cells-O', 'from-O', 'all-O', 'the-O', 'epithelial-O', 'layers-O', '.-O']
['Delayed-O', 'cystitis-B-Disease', 'still-O', 'persisted-O', 'in-O', 'DBA-O', '/-O', '2-O', 'mice-O', '100-O', 'days-O', 'after-O', 'treatment-O', '.-O']
['These-O', 'results-O', 'indicate-O', 'that-O', 'delayed-O', 'toxicity-O', 'of-O', 'CY-B-Chemical', 'in-O', 'female-O', 'DBA-O', '/-O', '2-O', 'mice-O', 'causes-O', 'a-O', 'bladder-O', 'pathology-O', 'that-O', 'is-O', 'not-O', 'observed-O', 'in-O', 'C57BL-O', '/-O', '6-O', 'mice-O', '.-O']
['This-O', 'pathology-O', 'resembles-O', 'interstitial-B-Disease', 'cystitis-I-Disease']
['High-O', ',-O', 'dose-O', '5-fluorouracil-B-Chemical', '/-O', 'folinic-B-Chemical', 'acid-I-Chemical', 'in-O', 'combination-O', 'with-O', 'three-O', ',-O', 'weekly-O', 'mitomycin-B-Chemical', 'C-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'advanced-O', 'gastric-B-Disease', 'cancer-I-Disease', '.-O']
['A-O', 'phase-O', 'II-O', 'study-O', '.-O']
['BACKGROUND-O', ':-O', 'The-O', '24-O', ',-O', 'hour-O', 'continuous-O', 'infusion-O', 'of-O', '5-fluorouracil-B-Chemical', '(-O', '5-FU-B-Chemical', ')-O', 'and-O', 'folinic-B-Chemical', 'acid-I-Chemical', '(-O', 'FA-B-Chemical', ')-O', 'as-O', 'part-O', 'of-O', 'several-O', 'new-O', 'multidrug-O', 'chemotherapy-O', 'regimens-O', 'in-O', 'advanced-O', 'gastric-B-Disease', 'cancer-I-Disease', '(-O', 'AGC-B-Disease', ')-O', 'has-O', 'shown-O', 'to-O', 'be-O', 'effective-O', ',-O', 'with-O', 'low-O', 'toxicity-O', '.-O']
['In-O', 'a-O', 'previous-O', 'phase-O', 'II-O', 'study-O', 'with-O', '3-O', ',', 'weekly-O', 'bolus-O', '5-FU-B-Chemical', ',', 'FA-B-Chemical', 'and-O', 'mitomycin-B-Chemical', 'C-O', '(-O', 'MMC-B-Chemical', ')', 'we-O', 'found-O', 'a-O', 'low-O', 'toxicity-B-Disease', 'rate-O', 'and-O', 'response-O', 'rates-O', 'comparable-O', 'to-O', 'those-O', 'of-O', 'regimens-O', 'such-O', 'as-O', 'ELF-B-Chemical', ',', 'FAM-B-Chemical', 'or-O', 'FAMTX-B-Chemical', ',', 'and-O', 'a-O', 'promising-O', 'median-O', 'overall-O', 'survival-O', '.-O']
['In-O', 'order-O', 'to-O', 'improve-O', 'this-O', 'MMC-B-Chemical', ',-O', 'dependent-O', 'schedule-O', 'we-O', 'initiated-O', 'a-O', 'phase-O', 'II-O', 'study-O', 'with-O', 'high-O', ',-O', 'dose-O', '5-FU-B-Chemical', '/-O', 'FA-B-Chemical', 'and-O', '3-O', ',-O', 'weekly-O', 'bolus-O', 'MMC-B-Chemical', '.-O']
['PATIENTS-O', 'AND-O', 'METHODS-O', ':-O', 'From-O', 'February-O', ',-O', '1998-O', 'to-O', 'September-O', ',-O', '2000-O', 'we-O', 'recruited-O', '33-O', 'patients-O', 'with-O', 'AGC-B-Disease', 'to-O', 'receive-O', 'weekly-O', '24-O', ',-O', 'hour-O', '5-FU-B-Chemical', '2-O', ',-O', '600-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'preceded-O', 'by-O', '2-O', ',-O', 'hour-O', 'FA-B-Chemical', '500-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'for-O', '6-O', 'weeks-O', ',-O', 'followed-O', 'by-O', 'a-O', '2-O', ',-O', 'week-O', 'rest-O', 'period-O', '.-O']
['Bolus-O', 'MMC-B-Chemical', '10-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')-O', 'was-O', 'added-O', 'in-O', '3-O', ',-O', 'weekly-O', 'intervals-O', '.-O']
['Treatment-O', 'given-O', 'on-O', 'an-O', 'outpatient-O', 'basis-O', ',-O', 'using-O', 'portable-O', 'pump-O', 'systems-O', ',-O', 'was-O', 'repeated-O', 'on-O', 'day-O', '57-O', '.-O']
['Patients-O', 'x-O', 'characteristics-O', 'were-O', ':-O', 'male-O', '/-O', 'female-O', 'ratio-O', '20-O', '/-O', '13-O', ';-O', 'median-O', 'age-O', '57-O', '(-O', '27-O', ',-O', '75-O', ')-O', 'years-O', ';-O', 'median-O', 'WHO-O', 'status-O', '1-O', '(-O', '0-O', ',-O', '2-O', ')-O', '.-O', '18-O', 'patients-O', 'had-O', 'a-O', 'primary-O', 'AGC-B-Disease', ',-O', 'and-O', '15-O', 'showed-O', 'a-O', 'relapsed-O', 'AGC-B-Disease', '.-O']
['Median-O', 'follow-O', ',-O', 'up-O', 'was-O', '11-O', '.-O']
['8-O', 'months-O', '(-O', 'range-O', 'of-O', 'those-O', 'surviving-O', ':-O', '2-O', '.-O']
['7-O', ',-O', '11-O', '.-O']
['8-O', 'months-O', ').-O', 'RESULTS-O', ':-O', '32-O', 'patients-O', 'were-O', 'evaluable-O', 'for-O', 'response-O', ',-O', 'complete-O', 'remission-O', '9-O', '.-O']
['1-O', '(-O', 'n-O', '=', '3-O', ')-O', 'partial-O', 'remission-O', '45-O', '.-O']
['5-O', '(-O', 'n-O', '='-O', '15-O', ')-O', 'no-O', 'change-O', '27-O', '.-O']
['3-O', '(-O', 'n-O', '=O', '9-O', ')-O', 'progressive-O', 'disease-B-Disease', '15-O', '.-O']
['1-O', '(-O', 'n-O', '=-O', '5-O', ')-O', '.-O', 'Median-O', 'overall-O', 'survival-O', 'time-O', 'was-O', '10-O', '.-O']
['2-O', 'months-O', '[', '95-O', '%-O', 'confidence-O', 'interval-O', '(-O', 'CI-O', '):-O', '8-O', '.-O']
['7-O', ',-O', '11-O', '.-O']
['6-O', ']-O', 'and-O', 'median-O', 'progression-O', ',-O', 'free-O', 'survival-O', 'time-O', 'was-O', '7-O', '.-O']
['6-O', 'months-O', '(-O', '95-O', '%-O', 'CI-O', ':-O', '4-O', '.-O']
['4-O', ',-O', '10-O', '.-O']
['9-O', ').-O', 'The-O', 'worst-O', 'toxicities-B-Disease', ',-O', 'observed-O', 'were-O', '(-O', 'CTC-O', ',-O', 'NCI-O', '1-O', '/', '2-O', '/', '3-O', ')-O', 'leukopenia-B-Disease', '45-O', '.-O']
['5-O', '/-O', '18-O', '.-O']
['2-O', '/-O', '6-O', '.-O']
['1-O', ',-O', 'thrombocytopenia-B-Disease', '33-O', '.-O']
['3-O', '/-O', '9-O', '.-O']
['1-O', '/-O', '6-O', '.-O']
['1-O', ',-O', 'vomitus-B-Disease', '24-O', '.-O']
['2-O', '/-O', '9-O', '.-O']
['1-O', '/-O', '0-O', ',-O', 'diarrhea-B-Disease', '36-O', '.-O']
['4-O', '/-O', '6-O', '.-O']
['1-O', '/-O', '3-O', '.-O']
['0-O', ',-O', 'stomatitis-B-Disease', '18-O', '.-O']
['2-O', '/-O', '9-O', '.-O']
['1-O', '/-O', '0-O', ',-O', 'hand-foot-B-Disease', 'syndrome-I-Disease', '12-O', '.-O']
['1-O', '/-O', '0-O', '/-O', '0-O', '.-O']
['Two-O', 'patients-O', 'developed-O', 'hemolytic-uremic-B-Disease', 'syndrome-I-Disease', '(-O', 'HUS-B-Disease', ')-O', '.-O', 'CONCLUSIONS-O', ':-O', 'High-O', ',-O', 'dose-O', '5-FU-B-Chemical', '/-O', 'FA-B-Chemical', '/-O', 'MMC-B-Chemical', 'is-O', 'an-O', 'effective-O', 'and-O', 'well-O', ',-O', 'tolerated-O', 'outpatient-O', 'regimen-O', 'for-O', 'AGC-B-Disease', '(-O', 'objective-O', 'response-O', 'rate-O', '54-O', '.-O']
['6-O', ').-O', 'It-O', 'may-O', 'serve-O', 'as-O', 'an-O', 'alternative-O', 'to-O', 'cisplatin-B-Chemical', ',-O', 'containing-O', 'regimens-O', ';-O', 'however-O', ',-O', 'it-O', 'has-O', 'to-O', 'be-O', 'considered-O', 'that-O', 'possibly-O', 'HUS-B-Disease']
['Persistent-O', 'sterile-O', 'leukocyturia-O', 'is-O', 'associated-O', 'with-O', 'impaired-O', 'renal-O', 'function-O', 'in-O', 'human-B-Disease', 'immunodeficiency-I-Disease', 'virus-I-Disease', 'type-O', '1-infected-I-Disease', 'children-O', 'treated-O', 'with-O', 'indinavir-B-Chemical', '.-O']
['BACKGROUND-O', ':-O', 'Prolonged-O', 'administration-O', 'of-O', 'indinavir-B-Chemical', 'is-O', 'associated-O', 'with-O', 'the-O', 'occurrence-O', 'of-O', 'a-O', 'variety-O', 'of-O', 'renal-O', 'complications-O', 'in-O', 'adults-O', '.-O']
['These-O', 'well-O', ',-O', 'documented-O', 'side-O', 'effects-O', 'have-O', 'restricted-O', 'the-O', 'use-O', 'of-O', 'this-O', 'potent-O', 'protease-O', 'inhibitor-O', 'in-O', 'children-O', '.-O']
['DESIGN-O', ':-O', 'A-O', 'prospective-O', 'study-O', 'to-O', 'monitor-O', 'indinavir-B-Chemical', ',-O', 'related-O', 'nephrotoxicity-B-Disease', 'in-O', 'a-O', 'cohort-O', 'of-O', '30-O', 'human-B-Disease', 'immunodeficiency-I-Disease', 'virus-I-Disease', 'type-O', '1-infected-I-Disease', 'children-O', 'treated-O', 'with-O', 'indinavir-B-Chemical', '.-O']
['METHODS-O', ':-O', 'Urinary-O', 'pH-O', ',-O', 'albumin-O', ',-O', 'creatinine-B-Chemical', ',-O', 'the-O', 'presence-O', 'of-O', 'erythrocytes-O', ',-O', 'leukocytes-O', ',-O', 'bacteria-O', 'and-O', 'crystals-O', ',-O', 'and-O', 'culture-O', 'were-O', 'analyzed-O', 'every-O', '3-O', 'months-O', 'for-O', '96-O', 'weeks-O', '.-O']
['Serum-O', 'creatinine-B-Chemical', 'levels-O', 'were-O', 'routinely-O', 'determined-O', 'at-O', 'the-O', 'same-O', 'time-O', 'points-O', '.-O']
['Steady-O', ',-O', 'state-O', 'pharmacokinetics-O', 'of-O', 'indinavir-B-Chemical', 'were-O', 'done-O', 'at-O', 'week-O', '4-O', 'after-O', 'the-O', 'initiation-O', 'of-O', 'indinavir-B-Chemical', '.-O']
['RESULTS-O', ':-O', 'The-O', 'cumulative-O', 'incidence-O', 'of-O', 'persistent-O', 'sterile-O', 'leukocyturia-B-Disease', '(>-O', 'or-O', '='-O', '75-O', 'cells-O', '/-O', 'micro-O', 'L-O', 'in-O', 'at-O', 'least-O', '2-O', 'consecutive-O', 'visits-O', ')-O', 'after-O', '96-O', 'weeks-O', 'was-O', '53-O', '.-O', 'Persistent-O', 'sterile-O', 'leukocyturia-B-Disease', 'was-O', 'frequently-O', 'associated-O', 'with-O', 'a-O', 'mild-O', 'increase-O', 'in-O', 'the-O', 'urine-O', 'albumin-O', '/-O', 'creatinine-B-Chemical', 'ratio-O', 'and-O', 'by-O', 'microscopic-O', 'hematuria-B-Disease', '.-O']
['The-O', 'cumulative-O', 'incidence-O', 'of-O', 'serum-O', 'creatinine-B-Chemical', 'levels-O', '>-O', '50-O', '%-O', 'above-O', 'normal-O', 'was-O', '33-O', '%-O', 'after-O', '96-O', 'weeks-O', '.-O']
['Children-O', 'with-O', 'persistent-O', 'sterile-O', 'leukocyturia-B-Disease', 'more-O', 'frequently-O', 'had-O', 'serum-O', 'creatinine-B-Chemical', 'levels-O', 'of-O', '50-O', '%-O', 'above-O', 'normal-O', 'than-O', 'those-O', 'children-O', 'without-O', 'persistent-O', 'sterile-O', 'leukocyturia-B-Disease', '.-O']
['In-O', 'children-O', 'younger-O', 'than-O', '5-O', '.-O']
['6-O', 'years-O', ',-O', 'persistent-O', 'sterile-O', 'leukocyturia-B-Disease', 'was-O', 'significantly-O', 'more-O', 'frequent-O', 'than-O', 'in-O', 'older-O', 'children-O', '.-O']
['A-O', 'higher-O', 'cumulative-O', 'incidence-O', 'of-O', 'persistent-O', 'leukocyturia-B-Disease', 'was-O', 'found-O', 'in-O', 'children-O', 'with-O', 'an-O', 'area-O', 'under-O', 'the-O', 'curve-O', '>-O', '19-O', 'mg-O', '/-O', 'L-O', 'x-O', 'h-O', 'or-O', 'a-O', 'peak-O', 'serum-O', 'level-O', 'of-O', 'indinavir-B-Chemical', '>-O', '12-O', 'mg-O', '/-O', 'L-O', '.-O']
['In-O', '4-O', 'children-O', ',-O', 'indinavir-B-Chemical', 'was-O', 'discontinued-O', 'because-O', 'of-O', 'nephrotoxicity-B-Disease', '.-O']
['Subsequently-O', ',-O', 'the-O', 'serum-O', 'creatinine-B-Chemical', 'levels-O', 'decreased-O', ',-O', 'the-O', 'urine-O', 'albumin-O', '/-O', 'creatinine-B-Chemical', 'ratios-O', 'returned-O', 'to-O', 'zero-O', ',-O', 'and-O', 'the-O', 'leukocyturia-B-Disease', 'disappeared-O', 'within-O', '3-O', 'months-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Children-O', 'treated-O', 'with-O', 'indinavir-B-Chemical', 'have-O', 'a-O', 'high-O', 'cumulative-O', 'incidence-O', 'of-O', 'persistent-O', 'sterile-O', 'leukocyturia-B-Disease', '.-O']
['Children-O', 'with-O', 'persistent-O', 'sterile-O', 'leukocyturia-B-Disease', 'more-O', 'frequently-O', 'had-O', 'an-O', 'increase-O', 'in-O', 'serum-O', 'creatinine-B-Chemical', 'levels-O', 'of-O', '>-O', '50-O', '%-O', 'above-O', 'normal-O', '.-O']
['Younger-O', 'children-O', 'have-O', 'an-O', 'additional-O', 'risk-O', 'for-O', 'renal-B-Disease', 'complications-O', '.-O']
['The-O', 'impairment-O', 'of-O', 'the-O', 'renal-O', 'function-O', 'in-O', 'these-O', 'children-O', 'occurred-O', 'in-O', 'the-O', 'absence-O', 'of-O', 'clinical-O', 'symptoms-O', 'of-O', 'nephrolithiasis-B-Disease', '.-O']
['Indinavir-B-Chemical', ',-O', 'associated-O', 'nephrotoxicity-B-Disease', 'must-O', 'be-O', 'monitored-O', 'closely-O', ',-O', 'especially-O', 'in-O', 'children-O', 'with-O', 'risk-O', 'factors-O', 'such-O', 'as-O', 'persistent-O', 'sterile-O', 'leukocyturia-B-Disease', ',-O', 'age-O', '<-O', '5-O', '.-O']
['6-O', 'years-O', ',-O', 'an-O', 'area-O', 'under-O', 'the-O', 'curve-O', 'of-O', 'indinavir-B-Chemical']
['Utility-O', 'of-O', 'troponin-O', 'I-O', 'in-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', '.-O']
['Baseline-O', 'electrocardiogram-O', 'abnormalities-O', 'and-O', 'market-O', 'elevations-O', 'not-O', 'associated-O', 'with-O', 'myocardial-B-Disease', 'necrosis-O', 'make-O', 'accurate-O', 'diagnosis-O', 'of-O', 'myocardial-B-Disease', 'infarction-I-Disease', '(', 'MI-O', ')', 'difficult-O', 'in-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',', 'associated-O', 'chest-O', 'pain-O', '.-O']
['Troponin-B-Chemical', 'sampling-O', 'may-O', 'offer-O', 'greater-O', 'diagnostic-O', 'utility-O', 'in-O', 'these-O', 'patients-O', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'assess-O', 'outcomes-O', 'based-O', 'on-O', 'troponin-B-Chemical', 'positivity-O', 'in-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', 'chest-B-Disease', 'pain-I-Disease', 'admitted-O', 'for-O', 'exclusion-O', 'of-O', 'MI-B-Disease', '.-O']
['METHODS-O', ':-O', 'Outcomes-O', 'were-O', 'examined-O', 'in-O', 'patients-O', 'admitted-O', 'for-O', 'possible-O', 'MI-B-Disease', 'after-O', 'cocaine-B-Chemical', 'use-O', '.-O']
['All-O', 'patients-O', 'underwent-O', 'a-O', 'rapid-O', 'rule-O', ',-O', 'in-O', 'protocol-O', 'that-O', 'included-O', 'serial-O', 'sampling-O', 'of-O', 'creatine-B-Chemical', 'kinase-O', '(-O', 'CK-O', ')-O', ',', 'CK-O', ',-O', 'MB-O', ',-O', 'and-O', 'cardiac-O', 'troponin-O', 'I-O', '(-O', 'cTnI-O', ')-O', 'over-O', 'eight-O', 'hours-O', '.-O']
['Outcomes-O', 'included-O', 'CK-O', ',-O', 'MB-O', 'MI-B-Disease', '(-O', 'CK-O', ',-O', 'MB-O', '>-O', 'or-O', '=-O', '8-O', 'ng-O', '/-O', 'mL-O', 'with-O', 'a-O', 'relative-O', 'index-O', '[(-O', 'CK-O', ',-O', 'MB-O', 'x-O', '100-O', ')/-O', 'total-O', 'CK-O', ']-O', '>-O', 'or-O', '=-O', '4-O', ',-O', 'cardiac-O', 'death-B-Disease', ',-O', 'and-O', 'significant-O', 'coronary-O', 'disease-B-Disease', '(-O', '>-O', 'or-O', '=-O', '50-O', ').-O', 'RESULTS-O', ':-O', 'Of-O', 'the-O', '246-O', 'admitted-O', 'patients-O', ',-O', '34-O', '(-O', '14-O', ')-O', 'met-O', 'CK-O', ',-O', 'MB-O', 'criteria-O', 'for-O', 'MI-B-Disease', 'and-O', '38-O', '(-O', '16-O', ')-O', 'had-O', 'cTnI-O', 'elevations-O', '.-O']
['Angiography-O', 'was-O', 'performed-O', 'in-O', '29-O', 'of-O', '38-O', 'patients-O', 'who-O', 'were-O', 'cTnI-O', ',-O', 'positive-O', ',-O', 'with-O', 'significant-O', 'disease-O', 'present-O', 'in-O', '25-O', '(-O', '86-O', ').-O', 'Three-O', 'of-O', 'the-O', 'four-O', 'patients-O', 'without-O', 'significant-O', 'disease-O', 'who-O', 'had-O', 'cTnI-O', 'elevations-O', 'met-O', 'CK-O', ',-O', 'MB-O', 'criteria-O', 'for-O', 'MI-O', ',-O', 'and-O', 'the-O', 'other-O', 'had-O', 'a-O', 'peak-O', 'CK-O', ',-O', 'MB-O', 'level-O', 'of-O', '13-O', 'ng-O', '/-O', 'mL-O', '.-O']
['Sensitivities-O', ',-O', 'specificities-O', ',-O', 'and-O', 'positive-O', 'and-O', 'negative-O', 'likelihood-O', 'ratios-O', 'for-O', 'predicting-O', 'cardiac-B-Disease', 'death-B-Disease', 'or-O', 'significant-O', 'disease-B-Disease', 'were-O', 'high-O', 'for-O', 'both-O', 'CK-O', ',-O', 'MB-O', 'MI-O', 'and-O', 'cTnI-O', 'and-O', 'were-O', 'not-O', 'significantly-O', 'different-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Most-O', 'patients-O', 'with-O', 'cTnI-B-Chemical', 'elevations-O', 'meet-O', 'CK-O', ',-O', 'MB-O', 'criteria-O', 'for-O', 'MI-B-Disease', ',-O', 'as-O', 'well-O', 'as-O', 'have-O', 'a-O', 'high-O', 'incidence-O', 'of-O', 'underlying-O', 'significant-O', 'disease-O', '.-O']
['Troponin-O', 'appears-O', 'to-O', 'have-O', 'an-O', 'equivalent-O', 'diagnostic-O', 'accuracy-O', 'compared-O', 'with-O', 'CK-O', ',-O', 'MB-O', 'for-O', 'diagnosing-O', 'necrosis-B-Disease', 'in-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', 'and-O', 'suspected-O', 'MI-B-Disease']
['Acute-B-Disease', 'interstitial-B-Disease', 'nephritis-I-Disease', 'due-O', 'to-O', 'nicergoline-B-Chemical', '(-O', 'Sermion-B-Chemical', ').-O', 'We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'acute-B-Disease', 'interstitial-B-Disease', 'nephritis-I-Disease', '(-O', 'AIN-B-Disease', ').-O', 'A-O', '50-O', ',-O', 'year-O', ',-O', 'old-O', 'patient-O', 'admitted-O', 'to-O', 'our-O', 'hospital-O', 'for-O', 'fever-O', 'and-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', '.-O']
['Before-O', 'admission-O', ',-O', 'he-O', 'had-O', 'been-O', 'taking-O', 'nicergoline-B-Chemical', 'and-O', 'bendazac-B-Chemical', 'lysine-B-Chemical', 'due-O', 'to-O', 'retinal-B-Disease', 'vein-I-Disease', 'occlusion-I-Disease', 'at-O', 'ophthalmologic-O', 'department-O', '.-O']
['Thereafter-O', ',-O', 'he-O', 'experienced-O', 'intermittent-O', 'fever-B-Disease', 'and-O', 'skin-O', 'rash-B-Disease', '.-O']
['On-O', 'admission-O', ',-O', 'clinical-O', 'symptoms-O', '(-O', 'i-O', '.-O']
['e-O', '.-O']
['arthralgia-B-Disease', 'and-O', 'fever-B-Disease', ')-O', 'and-O', 'laboratory-O', 'findings-O', '(-O', 'i-O', '.-O']
['e-O', '.-O']
['eosinophilia-B-Disease', 'and-O', 'renal-B-Disease', 'failure-I-Disease', ')-O', 'suggested-O', 'AIN-B-Disease', ',-O', 'and-O', 'which-O', 'was-O', 'confirmed-O', 'by-O', 'pathologic-O', 'findings-O', 'on-O', 'renal-O', 'biopsy-O', '.-O']
['A-O', 'lymphocyte-O', 'transformation-O', 'test-O', 'demonstrated-O', 'a-O', 'positive-O', 'result-O', 'against-O', 'nicergoline-B-Chemical', '.-O']
['Treatment-O', 'was-O', 'consisted-O', 'of-O', 'withdrawal-O', 'of-O', 'nicergoline-B-Chemical', 'and-O', 'intravenous-O', 'methylprednisolone-B-Chemical', ',-O', 'and-O', 'his-O', 'renal-O', 'function-O', 'was-O', 'completely-O', 'recovered-O', '.-O']
['To-O', 'our-O', 'knowledge-O', ',-O', 'this-O', 'is-O', 'the-O', 'first-O', 'report-O', 'of-O', 'nicergoline-B-Chemical', ',-O', 'associated-O', 'AIN-B-Disease']
['Neuroleptic-O', 'malignant-B-Disease', 'syndrome-I-Disease', 'complicated-O', 'by-O', 'massive-O', 'intestinal-O', 'bleeding-O', 'in-O', 'a-O', 'patient-O', 'with-O', 'chronic-B-Disease', 'renal-I-Disease', 'failure-I-Disease', '.-O']
['A-O', 'patient-O', 'with-O', 'chronic-B-Disease', 'renal-I-Disease', 'failure-I-Disease', '(-O', 'CRF-B-Disease', ')-O', 'developed-O', 'neuroleptic-O', 'malignant-O', 'syndrome-O', '(-O', 'NMS-B-Disease', ')-O', 'after-O', 'administration-O', 'of-O', 'risperidone-B-Chemical', 'and-O', 'levomepromazine-B-Chemical', '.-O']
['In-O', 'addition-O', 'to-O', 'the-O', 'typical-O', 'symptoms-O', 'of-O', 'NMS-B-Disease', ',-O', 'massive-O', 'intestinal-O', 'bleeding-B-Disease', 'was-O', 'observed-O', 'during-O', 'the-O', 'episode-O', '.-O']
['This-O', 'report-O', 'suggests-O', 'that-O', 'NMS-B-Disease', 'in-O', 'a-O', 'patient-O', 'with-O', 'CRF-B-Disease', 'may-O', 'be-O', 'complicated-O', 'by-O', 'intestinal-O', 'bleeding-B-Disease']
['Blood-O', 'brain-O', 'barrier-O', 'in-O', 'right-O', ',-O', 'and-O', 'left-O', ',-O', 'pawed-O', 'female-O', 'rats-O', 'assessed-O', 'by-O', 'a-O', 'new-O', 'staining-O', 'method-O', '.-O']
['The-O', 'asymmetrical-O', 'breakdown-O', 'of-O', 'the-O', 'blood-O', ',-O', 'brain-O', 'barrier-O', '(-O', 'BBB-O', ')-O', 'was-O', 'studied-O', 'in-O', 'female-O', 'rats-O', '.-O']
['Paw-O', 'preference-O', 'was-O', 'assessed-O', 'by-O', 'a-O', 'food-O', 'reaching-O', 'test-O', '.-O']
['Adrenaline-B-Chemical', ',-O', 'induced-O', 'hypertension-B-Disease', 'was-O', 'used-O', 'to-O', 'destroy-O', 'the-O', 'BBB-O', ',-O', 'which-O', 'was-O', 'evaluated-O', 'using-O', 'triphenyltetrazolium-B-Chemical', '(-O', 'TTC-O', ')-O', 'staining-O', 'of-O', 'the-O', 'brain-O', 'slices-O', 'just-O', 'after-O', 'giving-O', 'adrenaline-B-Chemical', 'for-O', '30-O', 's-O', '.-O']
['In-O', 'normal-O', 'rats-O', ',-O', 'the-O', 'whole-O', 'brain-O', 'sections-O', 'exhibited-O', 'complete-O', 'staining-O', 'with-O', 'TTC-B-Chemical', '.-O']
['After-O', 'adrenaline-B-Chemical', 'infusion-O', 'for-O', '30-O', 's-O', ',-O', 'there-O', 'were-O', 'large-O', 'unstained-O', 'areas-O', 'in-O', 'the-O', 'left-O', 'brain-O', 'in-O', 'right-O', ',-O', 'pawed-O', 'animals-O', ',-O', 'and-O', 'vice-O', 'versa-O', 'in-O', 'left-O', ',-O', 'pawed-O', 'animals-O', '.-O']
['Similar-O', 'results-O', 'were-O', 'obtained-O', 'in-O', 'seizure-B-Disease']
['Carvedilol-B-Chemical', 'protects-O', 'against-O', 'doxorubicin-B-Chemical', ',-O', 'induced-O', 'mitochondrial-O', 'cardiomyopathy-B-Disease', '.-O']
['Several-O', 'cytopathic-O', 'mechanisms-O', 'have-O', 'been-O', 'suggested-O', 'to-O', 'mediate-O', 'the-O', 'dose-O', ',-O', 'limiting-O', 'cumulative-O', 'and-O', 'irreversible-O', 'cardiomyopathy-B-Disease', 'caused-O', 'by-O', 'doxorubicin-B-Chemical', '.-O']
['Recent-O', 'evidence-O', 'indicates-O', 'that-O', 'oxidative-O', 'stress-O', 'and-O', 'mitochondrial-O', 'dysfunction-O', 'are-O', 'key-O', 'factors-O', 'in-O', 'the-O', 'pathogenic-O', 'process-O', '.-O']
['The-O', 'objective-O', 'of-O', 'this-O', 'investigation-O', 'was-O', 'to-O', 'test-O', 'the-O', 'hypothesis-O', 'that-O', 'carvedilol-B-Chemical', ',-O', 'a-O', 'nonselective-O', 'beta-O', ',-O', 'adrenergic-O', 'receptor-O', 'antagonist-O', 'with-O', 'potent-O', 'antioxidant-O', 'properties-O', ',-O', 'protects-O', 'against-O', 'the-O', 'cardiac-B-Disease', 'and-O', 'hepatic-B-Disease', 'mitochondrial-O', 'bioenergetic-O', 'dysfunction-O', 'associated-O', 'with-O', 'subchronic-O', 'doxorubicin-B-Chemical', 'toxicity-O', '.-O']
['Heart-O', 'and-O', 'liver-O', 'mitochondria-O', 'were-O', 'isolated-O', 'from-O', 'rats-O', 'treated-O', 'for-O', '7-O', 'weeks-O', 'with-O', 'doxorubicin-B-Chemical', '(-O', '2-O', 'mg-O', '/-O', 'kg-O', 'sc-O', '/-O', 'week-O', ')-O', 'carvedilol-B-Chemical', '(-O', '1-O', 'mg-O', '/-O', 'kg-O', 'ip-O', '/-O', 'week-O', ')-O', 'or-O', 'the-O', 'combination-O', 'of-O', 'the-O', 'two-O', 'drugs-O', '.-O']
['Heart-O', 'mitochondria-O', 'isolated-O', 'from-O', 'doxorubicin-B-Chemical', ',-O', 'treated-O', 'rats-O', 'exhibited-O', 'depressed-O', 'rates-O', 'for-O', 'state-O', '3-O', 'respiration-O', '(-O', '336-O', '+-O', '26-O', 'versus-O', '425-O', '+-O', '53-O', 'natom-O', 'O-O', '/-O', 'min-O', '/-O', 'mg-O', 'protein-O', ')-O', 'and-O', 'a-O', 'lower-O', 'respiratory-O', 'control-O', 'ratio-O', '(-O', 'RCR-O', ')-O', '(-O', '4-O', '.-O']
['3-O', '+-O', '0-O', '.-O']
['6-O', 'versus-O', '5-O', '.-O']
['8-O', '+-O', '0-O', '.-O']
['4-O', ')-O', 'compared-O', 'with-O', 'cardiac-B-Disease', 'mitochondria-O', 'isolated-O', 'from-O', 'saline-O', ',-O', 'treated-O', 'rats-O', '.-O']
['Mitochondrial-O', 'calcium-B-Chemical', ',-O', 'loading-O', 'capacity-O', 'and-O', 'the-O', 'activity-O', 'of-O', 'NADH-B-Chemical', ',-O', 'dehydrogenase-O', 'were-O', 'also-O', 'suppressed-O', 'in-O', 'cardiac-O', 'mitochondria-O', 'from-O', 'doxorubicin-B-Chemical', ',-O', 'treated-O', 'rats-O', '.-O']
['Doxorubicin-B-Chemical', 'treatment-O', 'also-O', 'caused-O', 'a-O', 'decrease-O', 'in-O', 'RCR-O', 'for-O', 'liver-O', 'mitochondria-O', '(-O', '3-O', '.-O']
['9-O', '+-O', '0-O', '.-O']
['9-O', 'versus-O', '5-O', '.-O']
['6-O', '+-O', '0-O', '.-O']
['7-O', 'for-O', 'control-O', 'rats-O', ')-O', 'and-O', 'inhibition-O', 'of-O', 'hepatic-O', 'cytochrome-O', 'oxidase-O', 'activity-O', '.-O']
['Coadministration-O', 'of-O', 'carvedilol-B-Chemical', 'decreased-O', 'the-O', 'extent-O', 'of-O', 'cellular-O', 'vacuolization-O', 'in-O', 'cardiac-O', 'myocytes-O', 'and-O', 'prevented-O', 'the-O', 'inhibitory-O', 'effect-O', 'of-O', 'doxorubicin-B-Chemical', 'on-O', 'mitochondrial-O', 'respiration-O', 'in-O', 'both-O', 'heart-O', 'and-O', 'liver-O', '.-O']
['Carvedilol-B-Chemical', 'also-O', 'prevented-O', 'the-O', 'decrease-O', 'in-O', 'mitochondrial-O', 'Ca-B-Chemical', '(-O', '2-O', ')', 'loading-O', 'capacity-O', 'and-O', 'the-O', 'inhibition-O', 'of-O', 'the-O', 'respiratory-O', 'complexes-O', 'of-O', 'heart-O', 'mitochondria-O', 'caused-O', 'by-O', 'doxorubicin-B-Chemical', '.-O']
['Carvedilol-B-Chemical', 'by-O', 'itself-O', 'did-O', 'not-O', 'affect-O', 'any-O', 'of-O', 'the-O', 'parameters-O', 'measured-O', 'for-O', 'heart-O', 'or-O', 'liver-O', 'mitochondria-O', '.-O']
['It-O', 'is-O', 'concluded-O', 'that-O', 'this-O', 'protection-O', 'by-O', 'carvedilol-B-Chemical', 'against-O', 'both-O', 'the-O', 'structural-O', 'and-O', 'functional-O', 'cardiac-O', 'tissue-O', 'damage-O', 'may-O', 'afford-O', 'significant-O', 'clinical-O', 'advantage-O', 'in-O', 'minimizing-O', 'the-O', 'dose-O', ',-O', 'limiting-O', 'mitochondrial-O', 'dysfunction-O', 'and-O', 'cardiomyopathy-B-Disease', 'that-O', 'accompanies-O', 'long-O', ',-O', 'term-O', 'doxorubicin-B-Chemical', 'therapy-O', 'in-O', 'cancer-B-Disease']
['Cocaine-B-Chemical', ',-O', 'induced-O', 'hyperactivity-B-Disease', 'is-O', 'more-O', 'influenced-O', 'by-O', 'adenosine-B-Chemical', 'receptor-O', 'agonists-O', 'than-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'hyperactivity-B-Disease', '.-O']
['The-O', 'influence-O', 'of-O', 'adenosine-B-Chemical', 'receptor-O', 'agonists-O', 'and-O', 'antagonists-O', 'on-O', 'cocaine-B-Chemical', ',-O', 'and-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'hyperactivity-B-Disease', 'was-O', 'examined-O', 'in-O', 'mice-O', '.-O']
['All-O', 'adenosine-B-Chemical', 'receptor-O', 'agonists-O', 'significantly-O', 'decreased-O', 'the-O', 'locomotor-O', 'activity-O', 'in-O', 'mice-O', ',-O', 'and-O', 'the-O', 'effects-O', 'were-O', 'dose-O', ',-O', 'dependent-O', '.-O']
['It-O', 'seems-O', 'that-O', 'adenosine-B-Chemical', 'A1-O', 'and-O', 'A2-O', 'receptors-O', 'might-O', 'be-O', 'involved-O', 'in-O', 'this-O', 'reaction-O', '.-O']
['Moreover-O', ',-O', 'all-O', 'adenosine-B-Chemical', 'receptor-O', 'agonists-O', ':-O', '2-p-(2-carboxyethyl)phenethylamino-5\'-N-ethylcarboxamidoadenosine-I-Chemical', '(-O', 'CGS-B-Chemical', '21680-I-Chemical', ')-O', 'A2A-O', 'receptor-O', 'agonist-O', ',-O', 'N6-cyclopentyladenosine-I-Chemical', '(-O', 'CPA-B-Chemical', ')-O', 'A1-O', 'receptor-O', 'agonist-O', ',-O', 'and-O', '5\'-N-ethylcarboxamidoadenosine-I-Chemical', '(-O', 'NECA-B-Chemical', ')-O', 'A2-O', '/-O', 'A1-O', 'receptor-O', 'agonist-O', 'significantly-O', 'and-O', 'dose-O', ',-O', 'dependently-O', 'decreased-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'locomotor-O', 'activity-O', '.-O']
['CPA-B-Chemical', 'reduced-O', 'cocaine-B-Chemical', 'action-O', 'at-O', 'the-O', 'doses-O', 'which-O', ',-O', 'given-O', 'alone-O', ',-O', 'did-O', 'not-O', 'influence-O', 'motility-O', ',-O', 'while-O', 'CGS-B-Chemical', '21680-B-Chemical', 'and-O', 'NECA-B-Chemical', 'decreased-O', 'the-O', 'action-O', 'of-O', 'cocaine-B-Chemical', 'at-O', 'the-O', 'doses-O', 'which-O', ',-O', 'given-O', 'alone-O', ',-O', 'decreased-O', 'locomotor-O', 'activity-O', 'in-O', 'animals-O', '.-O']
['These-O', 'results-O', 'suggest-O', 'the-O', 'involvement-O', 'of-O', 'both-O', 'adenosine-B-Chemical', 'receptors-O', 'in-O', 'the-O', 'action-O', 'of-O', 'cocaine-B-Chemical', 'although-O', 'agonists-O', 'of-O', 'A1-O', 'receptors-O', 'seem-O', 'to-O', 'have-O', 'stronger-O', 'influence-O', 'on-O', 'it-O', '.-O']
['The-O', 'selective-O', 'blockade-O', 'of-O', 'A2-O', 'adenosine-B-Chemical', 'receptor-O', 'by-O', 'DMPX-B-Chemical', '(-O', '3,7-dimethyl-1-propargylxanthine-B-Chemical', ')-O', 'significantly-O', 'enhanced-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'locomotor-O', 'activity-O', 'of-O', 'animals-O', '.-O']
['Caffeine-B-Chemical', 'had-O', 'similar-O', 'action-O', 'but-O', 'the-O', 'effect-O', 'was-O', 'not-O', 'significant-O', '.-O']
['CPT-O', '(-O', '8-cyclopentyltheophylline-B-Chemical', ')-O', 'A1-O', 'receptor-O', 'antagonist-O', ',-O', 'did-O', 'not-O', 'show-O', 'any-O', 'influence-O', 'in-O', 'this-O', 'test-O', '.-O']
['Similarly-O', ',-O', 'all-O', 'adenosine-B-Chemical', 'receptor-O', 'agonists-O', 'decreased-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'hyperactivity-B-Disease', ',-O', 'but-O', 'at-O', 'the-O', 'higher-O', 'doses-O', 'than-O', 'those-O', 'which-O', 'were-O', 'active-O', 'in-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'hyperactivity-B-Disease', '.-O']
['The-O', 'selective-O', 'blockade-O', 'of-O', 'A2-O', 'adenosine-B-Chemical', 'receptors-O', '(-O', 'DMPX-B-Chemical', ')-O', 'and-O', 'non-O', ',-O', 'selective-O', 'blockade-O', 'of-O', 'adenosine-B-Chemical', 'receptors-O', '(-O', 'caffeine-B-Chemical', ')-O', 'significantly-O', 'increased-O', 'the-O', 'action-O', 'of-O', 'amphetamine-B-Chemical', 'in-O', 'the-O', 'locomotor-O', 'activity-O', 'test-O', '.-O']
['Our-O', 'results-O', 'have-O', 'shown-O', 'that-O', 'all-O', 'adenosine-B-Chemical', 'receptor-O', 'agonists-O', '(-O', 'A1-O', 'and-O', 'A2-O', ')-O', 'reduce-O', 'cocaine-B-Chemical', ',-O', 'and-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'locomotor-O', 'activity-O', 'and-O', 'indicate-O', 'that-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'hyperactivity-B-Disease', 'is-O', 'more-O', 'influenced-O', 'by-O', 'adenosine-B-Chemical', 'receptor-O', 'agonists-O', '(-O', 'particularly-O', 'A1-O', 'receptors-O', ')-O', 'than-O', 'amphetamine-B-Chemical', ',-O', 'induced-O', 'hyperactivity-B-Disease']
['Amiodarone-B-Chemical', 'and-O', 'the-O', 'risk-O', 'of-O', 'bradyarrhythmia-B-Disease', 'requiring-O', 'permanent-O', 'pacemaker-O', 'in-O', 'elderly-O', 'patients-O', 'with-O', 'atrial-B-Disease', 'fibrillation-I-Disease', 'and-O', 'prior-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['OBJECTIVES-O', ':-O', 'The-O', 'aim-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'determine-O', 'whether-O', 'the-O', 'use-O', 'of-O', 'amiodarone-B-Chemical', 'in-O', 'patients-O', 'with-O', 'atrial-B-Disease', 'fibrillation-I-Disease', '(-O', 'AF-I-Disease', ')-O', 'increases-O', 'the-O', 'risk-O', 'of-O', 'bradyarrhythmia-B-Disease', 'requiring-O', 'a-O', 'permanent-O', 'pacemaker-O', '.-O']
['BACKGROUND-O', ':-O', 'Reports-O', 'of-O', 'severe-O', 'bradyarrhythmia-B-Disease', 'during-O', 'amiodarone-B-Chemical', 'therapy-O', 'are-O', 'infrequent-O', 'and-O', 'limited-O', 'to-O', 'studies-O', 'assessing-O', 'the-O', 'therapy-O', 'x-O', 's-O', 'use-O', 'in-O', 'the-O', 'management-O', 'of-O', 'patients-O', 'with-O', 'ventricular-B-Disease', 'arrhythmias-I-Disease', '.-O']
['METHODS-O', ':-O', 'A-O', 'study-O', 'cohort-O', 'of-O', '8-O', ',', '770-O', 'patients-O', 'age-O', '>O', 'or-O', '=O', '65-O', 'years-O', 'with-O', 'a-O', 'new-O', 'diagnosis-O', 'of-O', 'AF-B-Disease', 'was-O', 'identified-O', 'from-O', 'a-O', 'provincewide-O', 'database-O', 'of-O', 'Quebec-O', 'residents-O', 'with-O', 'a-O', 'myocardial-B-Disease', 'infarction-I-Disease', '(-O', 'MI-B-Disease', ')-O', 'between-O', '1991-O', 'and-O', '1999-O', '.-O']
['Using-O', 'a-O', 'nested-O', 'case-O', ',-O', 'control-O', 'design-O', ',-O', '477-O', 'cases-O', 'of-O', 'bradyarrhythmia-B-Disease', 'requiring-O', 'a-O', 'permanent-O', 'pacemaker-O', 'were-O', 'matched-O', '(-O', '1-O', ':-O', '4-O', ')-O', 'to-O', '1-O', ',-O', '908-O', 'controls-O', '.-O']
['Multivariable-O', 'logistic-O', 'regression-O', 'was-O', 'used-O', 'to-O', 'estimate-O', 'the-O', 'odds-O', 'ratio-O', '(-O', 'OR-O', ')-O', 'of-O', 'pacemaker-O', 'insertion-O', 'associated-O', 'with-O', 'amiodarone-B-Chemical', 'use-O', ',-O', 'controlling-O', 'for-O', 'baseline-O', 'risk-O', 'factors-O', 'and-O', 'exposure-O', 'to-O', 'sotalol-B-Chemical', ',-O', 'Class-O', 'I-O', 'antiarrhythmic-O', 'agents-O', ',-O', 'beta-O', ',-O', 'blockers-O', ',-O', 'calcium-B-Chemical', 'channel-O', 'blockers-O', ',-O', 'and-O', 'digoxin-B-Chemical', '.-O']
['RESULTS-O', ':-O', 'amiodarone-B-Chemical', 'use-O', 'was-O', 'associated-O', 'with-O', 'an-O', 'increased-O', 'risk-O', 'of-O', 'pacemaker-O', 'insertion-O', '(-O', 'OR-O', ':-O', '2-O', '.-O']
['14-O', ',-O', '95-O', '%-O', 'confidence-O', 'interval-O', '[', 'CI-O', ']:-O', '1-O', '.-O']
['30-O', 'to-O', '3-O', '.-O']
['54-O', ').-O', 'This-O', 'effect-O', 'was-O', 'modified-O', 'by-O', 'gender-O', ',-O', 'with-O', 'a-O', 'greater-O', 'risk-O', 'in-O', 'women-O', 'versus-O', 'men-O', '(-O', 'OR-O', ':-O', '3-O', '.-O']
['86-O', ',-O', '95-O', '%-O', 'CI-O', ':-O', '1-O', '.-O']
['70-O', 'to-O', '8-O', '.-O']
['75-O', 'vs-O', '.-O']
['OR-O', ':-O', '1-O', '.-O']
['52-O', ',-O', '95-O', '%-O', 'CI-O', ':-O', '0-O', '.-O']
['80-O', 'to-O', '2-O', '.-O']
['89-O', ').-O', 'Digoxin-B-Chemical', 'was-O', 'the-O', 'only-O', 'other-O', 'medication-O', 'associated-O', 'with-O', 'an-O', 'increased-O', 'risk-O', 'of-O', 'pacemaker-O', 'insertion-O', '(-O', 'OR-O', ':', '1-O', '.-O']
['78-O', ',-O', '95-O', '%-O', 'CI-O', ':-O', '1-O', '.-O']
['37-O', 'to-O', '2-O', '.-O']
['31-O', ').-O', 'CONCLUSIONS-O', ':-O', 'This-O', 'study-O', 'suggests-O', 'that-O', 'the-O', 'use-O', 'of-O', 'amiodarone-B-Chemical', 'in-O', 'elderly-O', 'patients-O', 'with-O', 'AF-B-Disease', 'and-O', 'a-O', 'previous-O', 'MI-B-Disease', 'increases-O', 'the-O', 'risk-O', 'of-O', 'bradyarrhythmia-B-Disease', 'requiring-O', 'a-O', 'permanent-O', 'pacemaker-O', '.-O']
['The-O', 'finding-O', 'of-O', 'an-O', 'augmented-O', 'risk-O', 'of-O', 'pacemaker-O', 'insertion-O', 'in-O', 'elderly-O', 'women-O', 'receiving-O', 'amiodarone-B-Chemical']
['Indomethacin-B-Chemical', ',-O', 'induced-O', 'morphologic-O', 'changes-O', 'in-O', 'the-O', 'rat-O', 'urinary-B-Disease', 'bladder-I-Disease', 'epithelium-O', '.-O']
['OBJECTIVES-O', ':-O', 'To-O', 'evaluate-O', 'the-O', 'morphologic-O', 'changes-O', 'in-O', 'rat-O', 'urothelium-O', 'induced-O', 'by-O', 'indomethacin-B-Chemical', '.-O']
['Nonsteroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'drug-O', ',-O', 'induced-O', 'cystitis-B-Disease', 'is-O', 'a-O', 'poorly-O', 'recognized-O', 'and-O', 'under-O', ',-O', 'reported-O', 'condition-O', '.-O']
['In-O', 'addition-O', 'to-O', 'tiaprofenic-B-Chemical', 'acid-I-Chemical', ',-O', 'indomethacin-B-Chemical', 'has-O', 'been-O', 'reported-O', 'to-O', 'be-O', 'associated-O', 'with-O', 'this-O', 'condition-O', '.-O']
['METHODS-O', ':', 'Three-O', 'groups-O', 'were-O', 'established-O', ':', 'a-O', 'control-O', 'group-O', '(-O', 'n-O', '=-O', '10-O', ')-O', ',', 'a-O', 'high-O', ',-O', 'dose-O', 'group-O', '(-O', 'n-O', '=-O', '10-O', ')-O', ',', 'treated-O', 'with-O', 'one-O', 'intraperitoneal-O', 'injection-O', 'of-O', 'indomethacin-B-Chemical', '20-O', 'mg-O', '/-O', 'kg-O', ',-O', 'and-O', 'a-O', 'therapeutic-O', 'dose-O', 'group-O', '(-O', 'n-O', '=-O', '10-O', ')-O', 'in-O', 'which-O', 'oral-O', 'indomethacin-B-Chemical', 'was-O', 'administered-O', '3-O', '.-O']
['25-O', 'mg-O', '/-O', 'kg-O', 'body-O', 'weight-O', 'daily-O', 'for-O', '3-O', 'weeks-O', '.-O']
['The-O', 'animals-O', 'were-O', 'then-O', 'killed-O', 'and-O', 'the-O', 'bladders-O', 'removed-O', 'for-O', 'light-O', 'and-O', 'electron-O', 'microscopic-O', 'studies-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'light-O', 'microscopic-O', 'findings-O', 'showed-O', 'some-O', 'focal-O', 'epithelial-O', 'degeneration-B-Disease', 'that-O', 'was-O', 'more-O', 'prominent-O', 'in-O', 'the-O', 'high-O', ',-O', 'dose-O', 'group-O', '.-O']
['When-O', 'compared-O', 'with-O', 'the-O', 'control-O', 'group-O', ',-O', 'both-O', 'indomethacin-B-Chemical', 'groups-O', 'revealed-O', 'statistically-O', 'increased-O', 'numbers-O', 'of-O', 'mast-O', 'cells-O', 'in-O', 'the-O', 'mucosa-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['0001-O', ')-O', 'and-O', 'penetration-O', 'of-O', 'lanthanum-B-Chemical', 'nitrate-B-Chemical', 'through-O', 'intercellular-O', 'areas-O', 'of-O', 'the-O', 'epithelium-O', '.-O']
['Furthermore-O', ',-O', 'the-O', 'difference-O', 'in-O', 'mast-O', 'cell-O', 'counts-O', 'between-O', 'the-O', 'high-O', 'and-O', 'therapeutic-O', 'dose-O', 'groups-O', 'was-O', 'also-O', 'statistically-O', 'significant-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['0001-O', ').-O', 'CONCLUSIONS-O', ':-O', 'Indomethacin-B-Chemical', 'resulted-O', 'in-O', 'histopathologic-O', 'findings-O', 'typical-O', 'of-O', 'interstitial-B-Disease', 'cystitis-B-Disease', ',-O', 'such-O', 'as-O', 'leaky-O', 'bladder-O', 'epithelium-O', 'and-O', 'mucosal-O', 'mastocytosis-B-Disease', '.-O']
['The-O', 'true-O', 'incidence-O', 'of-O', 'nonsteroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'drug-O', ',-O', 'induced-O', 'cystitis-B-Disease']
['An-O', 'open-O', ',-O', 'label-O', 'phase-O', 'II-O', 'study-O', 'of-O', 'low-O', ',-O', 'dose-O', 'thalidomide-B-Chemical', 'in-O', 'androgen-O', ',-O', 'independent-O', 'prostate-B-Disease', 'cancer-I-Disease', '.-O']
['The-O', 'antiangiogenic-O', 'effects-O', 'of-O', 'thalidomide-B-Chemical', 'have-O', 'been-O', 'assessed-O', 'in-O', 'clinical-O', 'trials-O', 'in-O', 'patients-O', 'with-O', 'various-O', 'solid-O', 'and-O', 'haematological-O', 'malignancies-B-Disease', '.-O']
['Thalidomide-B-Chemical', 'blocks-O', 'the-O', 'activity-O', 'of-O', 'angiogenic-O', 'agents-O', 'including-O', 'bFGF-B-Chemical', ',-O', 'VEGF-B-Chemical', 'and-O', 'IL-O', ',-O', '6-O', '.-O']
['We-O', 'undertook-O', 'an-O', 'open-O', ',-O', 'label-O', 'study-O', 'using-O', 'thalidomide-B-Chemical', '100-O', 'mg-O', 'once-O', 'daily-O', 'for-O', 'up-O', 'to-O', '6-O', 'months-O', 'in-O', '20-O', 'men-O', 'with-O', 'androgen-O', ',-O', 'independent-O', 'prostate-B-Disease', 'cancer-I-Disease', '.-O']
['The-O', 'mean-O', 'time-O', 'of-O', 'study-O', 'was-O', '109-O', 'days-O', '(-O', 'median-O', '107-O', ',-O', 'range-O', '4-O', ',-O', '184-O', 'days-O', ').-O', 'Patients-O', 'underwent-O', 'regular-O', 'measurement-O', 'of-O', 'prostate-O', ',-O', 'specific-O', 'antigen-O', '(-O', 'PSA-O', ')-O', ',-O', 'urea-B-Chemical', 'and-O', 'electrolytes-O', ',-O', 'serum-O', 'bFGF-B-Chemical', 'and-O', 'VEGF-B-Chemical', '.-O']
['Three-O', 'men-O', '(-O', '15-O', ')-O', 'showed-O', 'a-O', 'decline-O', 'in-O', 'serum-O', 'PSA-B-Chemical', 'of-O', 'at-O', 'least-O', '50-O', ',-O', 'sustained-O', 'throughout-O', 'treatment-O', '.-O']
['Of-O', '16-O', 'men-O', 'treated-O', 'for-O', 'at-O', 'least-O', '2-O', 'months-O', ',-O', 'six-O', '(-O', '37-O', '.-O']
['5-O', ')-O', 'showed-O', 'a-O', 'fall-O', 'in-O', 'absolute-O', 'PSA-B-Chemical', 'by-O', 'a-O', 'median-O', 'of-O', '48-O', '.-O', 'Increasing-O', 'levels-O', 'of-O', 'serum-O', 'bFGF-B-Chemical', 'and-O', 'VEGF-B-Chemical', 'were-O', 'associated-O', 'with-O', 'progressive-O', 'disease-O', ';-O', 'five-O', 'of-O', 'six-O', 'men-O', 'who-O', 'demonstrated-O', 'a-O', 'fall-O', 'in-O', 'PSA-B-Chemical', 'also-O', 'showed-O', 'a-O', 'decline-O', 'in-O', 'bFGF-B-Chemical', 'and-O', 'VEGF-B-Chemical', 'levels-O', ',-O', 'and-O', 'three-O', 'of-O', 'four-O', 'men-O', 'with-O', 'a-O', 'rising-O', 'PSA-B-Chemical', 'showed-O', 'an-O', 'increase-O', 'in-O', 'both-O', 'growth-O', 'factors-O', '.-O']
['Adverse-O', 'effects-O', 'included-O', 'constipation-B-Disease', ',', 'morning-O', 'drowsiness-B-Disease', ',', 'dizziness-B-Disease', 'and-O', 'rash-B-Disease', ',', 'and-O', 'resulted-O', 'in-O', 'withdrawal-O', 'from-O', 'the-O', 'study-O', 'by-O', 'three-O', 'men-O', '.-O']
['Evidence-O', 'of-O', 'peripheral-B-Disease', 'sensory-O', 'neuropathy-I-Disease', 'was-O', 'found-O', 'in-O', 'nine-O', 'of-O', '13-O', 'men-O', 'before-O', 'treatment-O', '.-O']
['In-O', 'the-O', 'seven-O', 'men-O', 'who-O', 'completed-O', 'six-O', 'months-O', 'on-O', 'thalidomide-B-Chemical', ',-O', 'subclinical-O', 'evidence-O', 'of-O', 'peripheral-B-Disease', 'neuropathy-I-Disease', 'was-O', 'found-O', 'in-O', 'four-O', 'before-O', 'treatment-O', ',-O', 'but-O', 'in-O', 'all-O', 'seven-O', 'at-O', 'repeat-O', 'testing-O', '.-O']
['The-O', 'findings-O', 'indicate-O', 'that-O', 'thalidomide-B-Chemical', 'may-O', 'be-O', 'an-O', 'option-O', 'for-O', 'patients-O', 'who-O', 'have-O', 'failed-O', 'other-O', 'forms-O', 'of-O', 'therapy-O', ',-O', 'provided-O', 'close-O', 'follow-O', ',-O', 'up-O', 'is-O', 'maintained-O', 'for-O', 'development-O', 'of-O', 'peripheral-B-Disease', 'neuropathy-I-Disease']
['Central-O', 'nervous-O', 'system-O', 'toxicity-B-Disease', 'following-O', 'the-O', 'administration-O', 'of-O', 'levobupivacaine-B-Chemical', 'for-O', 'lumbar-O', 'plexus-O', 'block-O', ':-O', 'A-O', 'report-O', 'of-O', 'two-O', 'cases-O', '.-O']
['BACKGROUND-O', 'AND-O', 'OBJECTIVES-O', ':-O', 'Central-O', 'nervous-O', 'system-O', 'and-O', 'cardiac-O', 'toxicity-B-Disease', 'following-O', 'the-O', 'administration-O', 'of-O', 'local-O', 'anesthetics-O', 'is-O', 'a-O', 'recognized-O', 'complication-O', 'of-O', 'regional-O', 'anesthesia-O', '.-O']
['Levobupivacaine-B-Chemical', ',-O', 'the-O', 'pure-O', 'S-O', '(-)-O', 'enantiomer-O', 'of-O', 'bupivacaine-B-Chemical', ',-O', 'was-O', 'developed-O', 'to-O', 'improve-O', 'the-O', 'cardiac-O', 'safety-O', 'profile-O', 'of-O', 'bupivacaine-B-Chemical', '.-O']
['We-O', 'describe-O', '2-O', 'cases-O', 'of-O', 'grand-O', 'mal-B-Disease', 'seizures-B-Disease', 'following-O', 'accidental-O', 'intravascular-O', 'injection-O', 'of-O', 'levobupivacaine-B-Chemical', '.-O']
['CASE-O', 'REPORT-O', ':-O', 'Two-O', 'patients-O', 'presenting-O', 'for-O', 'elective-O', 'orthopedic-O', 'surgery-O', 'of-O', 'the-O', 'lower-O', 'limb-O', 'underwent-O', 'blockade-O', 'of-O', 'the-O', 'lumbar-O', 'plexus-O', 'via-O', 'the-O', 'posterior-O', 'approach-O', '.-O']
['Immediately-O', 'after-O', 'the-O', 'administration-O', 'of-O', 'levobupivacaine-B-Chemical', '0-O', '.-O']
['5-O', '%-O', 'with-O', 'epinephrine-B-Chemical', '2-O', '.-O']
['5-O', 'microgram-O', '/-O', 'mL-O', ',-O', 'the-O', 'patients-O', 'developed-O', 'grand-O', 'mal-O', 'seizures-B-Disease', ',-O', 'despite-O', 'negative-O', 'aspiration-O', 'for-O', 'blood-O', 'and-O', 'no-O', 'clinical-O', 'signs-O', 'of-O', 'intravenous-O', 'epinephrine-B-Chemical', 'administration-O', '.-O']
['The-O', 'seizures-B-Disease', 'were-O', 'successfully-O', 'treated-O', 'with-O', 'sodium-B-Chemical', 'thiopental-B-Chemical', 'in-O', 'addition-O', 'to-O', 'succinylcholine-B-Chemical', 'in-O', '1-O', 'patient-O', '.-O']
['Neither-O', 'patient-O', 'developed-O', 'signs-O', 'of-O', 'cardiovascular-B-Disease', 'toxicity-I-Disease', '.-O']
['Both-O', 'patients-O', 'were-O', 'treated-O', 'preoperatively-O', 'with-O', 'beta-O', ',-O', 'adrenergic-O', 'antagonist-O', 'medications-O', ',-O', 'which-O', 'may-O', 'have-O', 'masked-O', 'the-O', 'cardiovascular-O', 'signs-O', 'of-O', 'the-O', 'unintentional-O', 'intravascular-O', 'administration-O', 'of-O', 'levobupivacaine-B-Chemical', 'with-O', 'epinephrine-B-Chemical', '.-O']
['CONCLUSIONS-O', ':-O', 'Although-O', 'levobupivacaine-B-Chemical', 'may-O', 'have-O', 'a-O', 'safer-O', 'cardiac-O', 'toxicity-O', 'profile-O', 'than-O', 'racemic-O', 'bupivacaine-B-Chemical', ',-O', 'if-O', 'adequate-O', 'amounts-O', 'of-O', 'levobupivacaine-B-Chemical', 'reach-O', 'the-O', 'circulation-O', ',-O', 'it-O', 'will-O', 'result-O', 'in-O', 'convulsions-B-Disease', '.-O']
['Plasma-O', 'concentrations-O', 'sufficient-O', 'to-O', 'result-O', 'in-O', 'central-O', 'nervous-O', 'system-O', 'toxicity-B-Disease', 'did-O', 'not-O', 'produce-O', 'manifestations-O', 'of-O', 'cardiac-O', 'toxicity-B-Disease']
['Anaesthetic-O', 'complications-O', 'associated-O', 'with-O', 'myotonia-B-Disease', 'congenita-I-Disease', ':-O', 'case-O', 'study-O', 'and-O', 'comparison-O', 'with-O', 'other-O', 'myotonic-B-Disease', 'disorders-O', '.-O']
['Myotonia-B-Disease', 'congenita-I-Disease', '(-O', 'MC-O', ')-O', 'is-O', 'caused-O', 'by-O', 'a-O', 'defect-O', 'in-O', 'the-O', 'skeletal-O', 'muscle-O', 'chloride-B-Chemical', 'channel-O', 'function-O', ',-O', 'which-O', 'may-O', 'cause-O', 'sustained-O', 'membrane-O', 'depolarisation-O', '.-O']
['We-O', 'describe-O', 'a-O', 'previously-O', 'healthy-O', '32-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'who-O', 'developed-O', 'a-O', 'life-O', ',-O', 'threatening-O', 'muscle-B-Disease', 'spasm-I-Disease', 'and-O', 'secondary-O', 'ventilation-O', 'difficulties-O', 'following-O', 'a-O', 'preoperative-O', 'injection-O', 'of-O', 'suxamethonium-B-Chemical', '.-O']
['The-O', 'muscle-B-Disease', 'spasms-I-Disease', 'disappeared-O', 'spontaneously-O', 'and-O', 'the-O', 'surgery-O', 'proceeded-O', 'without-O', 'further-O', 'problems-O', '.-O']
['When-O', 'subsequently-O', 'questioned-O', ',-O', 'she-O', 'reported-O', 'minor-O', 'symptoms-O', 'suggesting-O', 'a-O', 'myotonic-B-Disease', 'condition-O', '.-O']
['Myotonia-B-Disease', 'was-O', 'found-O', 'on-O', 'clinical-O', 'examination-O', 'and-O', 'EMG-O', '.-O']
['The-O', 'diagnosis-O', 'MC-B-Disease', 'was-O', 'confirmed-O', 'genetically-O', '.-O']
['Neither-O', 'the-O', 'patient-O', 'nor-O', 'the-O', 'anaesthetist-O', 'were-O', 'aware-O', 'of-O', 'the-O', 'diagnosis-O', 'before-O', 'this-O', 'potentially-O', 'lethal-O', 'complication-O', 'occurred-O', '.-O']
['We-O', 'give-O', 'a-O', 'brief-O', 'overview-O', 'of-O', 'ion-B-Chemical', 'channel-O', 'disorders-I-Disease', 'including-O', 'malignant-B-Disease', 'hyperthermia-I-Disease']
['Respiratory-O', 'pattern-O', 'in-O', 'a-O', 'rat-O', 'model-O', 'of-O', 'epilepsy-B-Disease', '.-O']
['PURPOSE-O', ':-O', 'Apnea-B-Disease', 'is-O', 'known-O', 'to-O', 'occur-O', 'during-O', 'seizures-B-Disease', ',-O', 'but-O', 'systematic-O', 'studies-O', 'of-O', 'ictal-O', 'respiratory-O', 'changes-O', 'in-O', 'adults-O', 'are-O', 'few-O', '.-O']
['Data-O', 'regarding-O', 'respiratory-B-Disease', 'pattern-O', 'defects-I-Disease', 'during-O', 'interictal-O', 'periods-O', 'also-O', 'are-O', 'scarce-O', '.-O']
['Here-O', 'we-O', 'sought-O', 'to-O', 'generate-O', 'information-O', 'with-O', 'regard-O', 'to-O', 'the-O', 'interictal-O', 'period-O', 'in-O', 'animals-O', 'with-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'epilepsy-B-Disease', '.-O']
['METHODS-O', ':-O', 'Twelve-O', 'rats-O', '(-O', 'six-O', 'chronically-O', 'epileptic-B-Disease', 'animals-O', 'and-O', 'six-O', 'controls-O', ')-O', 'were-O', 'anesthetized-O', ',-O', 'given-O', 'tracheotomies-O', ',-O', 'and-O', 'subjected-O', 'to-O', 'hyperventilation-O', 'or-O', 'hypoventilation-O', 'conditions-O', '.-O']
['Breathing-O', 'movements-O', 'caused-O', 'changes-O', 'in-O', 'thoracic-O', 'volume-O', 'and-O', 'forced-O', 'air-O', 'to-O', 'flow-O', 'tidally-O', 'through-O', 'a-O', 'pneumotachograph-O', '.-O']
['This-O', 'flow-O', 'was-O', 'measured-O', 'by-O', 'using-O', 'a-O', 'differential-O', 'pressure-O', 'transducer-O', ',-O', 'passed-O', 'through-O', 'a-O', 'polygraph-O', ',-O', 'and-O', 'from-O', 'this-O', 'to-O', 'a-O', 'computer-O', 'with-O', 'custom-O', 'software-O', 'that-O', 'derived-O', 'ventilation-O', '(-O', 'VE-O', ')-O', ',', 'tidal-O', 'volume-O', '(-O', 'VT-O', ')-O', ',', 'inspiratory-O', 'time-O', '(-O', 'TI-O', ')-O', ',', 'expiratory-O', 'time-O', '(-O', 'TE-O', ')-O', ',', 'breathing-O', 'frequency-O', '(-O', 'f-O', ')-O', ',', 'and-O', 'mean-O', 'inspiratory-O', 'flow-O', '(-O', 'VT-O', '/', 'TI-O', ')-O', 'on-O', 'a-O', 'breath-O', ',-O', 'by-O', ',-O', 'breath-O', 'basis-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'hyperventilation-O', 'maneuver-O', 'caused-O', 'a-O', 'decrease-O', 'in-O', 'spontaneous-O', 'ventilation-O', 'in-O', 'pilocarpine-B-Chemical', ',-O', 'treated-O', 'and-O', 'control-O', 'rats-O', '.-O']
['Although-O', 'VE-O', 'had-O', 'a-O', 'similar-O', 'decrease-O', 'in-O', 'both-O', 'groups-O', ',-O', 'in-O', 'the-O', 'epileptic-B-Disease', 'group-O', ',-O', 'the-O', 'decrease-O', 'in-O', 'VE-O', 'was-O', 'due-O', 'to-O', 'a-O', 'significant-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ')-O', 'increase-O', 'in-O', 'TE-B-Chemical', 'peak-O', 'in-O', 'relation-O', 'to-O', 'that-O', 'of-O', 'the-O', 'control-O', 'animals-O', '.-O']
['The-O', 'hypoventilation-B-Disease', 'maneuver-O', 'led-O', 'to-O', 'an-O', 'increase-O', 'in-O', 'the-O', 'arterial-O', 'Paco2-O', ',-O', 'followed-O', 'by-O', 'an-O', 'increase-O', 'in-O', 'VE-O', '.-O']
['In-O', 'the-O', 'epileptic-B-Disease', 'group-O', ',-O', 'the-O', 'increase-O', 'in-O', 'VE-O', 'was-O', 'mediated-O', 'by-O', 'a-O', 'significant-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ')-O', 'decrease-O', 'in-O', 'TE-O', 'peak-O', 'compared-O', 'with-O', 'the-O', 'control-O', 'group-O', '.-O']
['Systemic-O', 'application-O', 'of-O', 'KCN-B-Chemical', ',-O', 'to-O', 'evaluate-O', 'the-O', 'effects-O', 'of-O', 'peripheral-O', 'chemoreception-O', 'activation-O', 'on-O', 'ventilation-O', ',-O', 'led-O', 'to-O', 'a-O', 'similar-O', 'increase-O', 'in-O', 'VE-O', 'for-O', 'both-O', 'groups-O', '.-O']
['CONCLUSIONS-O', ':-O', 'The-O', 'data-O', 'indicate-O', 'that-O', 'pilocarpine-B-Chemical', ',-O', 'treated-O', 'animals-O', 'have-O', 'an-O', 'altered-O', 'ability-O', 'to-O', 'react-O', 'to-O', '(O', 'or-O', 'compensate-O', 'for-O', ')', 'blood-O', 'gas-O', 'changes-O', 'with-O', 'changes-O', 'in-O', 'ventilation-O', 'and-O', 'suggest-O', 'that-O', 'it-O', 'is-O', 'centrally-O', 'determined-O', '.-O']
['We-O', 'speculate-O', 'on-O', 'the-O', 'possible-O', 'relation-O', 'of-O', 'the-O', 'current-O', 'findings-O', 'on-O', 'treating-O', 'different-O', 'epilepsy-B-Disease']
['Increased-O', 'serum-O', 'soluble-O', 'Fas-O', 'in-O', 'patients-O', 'with-O', 'acute-B-Disease', 'liver-B-Disease', 'failure-I-Disease', 'due-O', 'to-O', 'paracetamol-B-Chemical', 'overdose-B-Disease', '.-O']
['BACKGROUND-O', '/', 'AIMS-O', ':-O', 'Experimental-O', 'studies-O', 'have-O', 'suggested-O', 'that-O', 'apoptosis-B-Disease', 'via-O', 'the-O', 'Fas-B-Chemical', '/', 'Fas-B-Chemical', 'Ligand-B-Chemical', 'signaling-O', 'system-O', 'may-O', 'play-O', 'an-O', 'important-O', 'role-O', 'in-O', 'the-O', 'development-O', 'of-O', 'acute-O', 'liver-B-Disease', 'failure-I-Disease', '.-O']
['The-O', 'aim-O', 'of-O', 'the-O', 'study-O', 'was-O', 'to-O', 'investigate-O', 'the-O', 'soluble-O', 'form-O', 'of-O', 'Fas-O', 'in-O', 'patients-O', 'with-O', 'acute-B-Disease', 'liver-B-Disease', 'failure-I-Disease', '.-O']
['METHODOLOGY-O', ':-O', 'Serum-O', 'levels-O', 'of-O', 'sFas-O', '(-O', 'soluble-O', 'Fas-O', ')-O', 'were-O', 'measured-O', 'by-O', 'ELISA-O', 'in-O', '24-O', 'patients-O', 'with-O', 'acute-B-Disease', 'liver-B-Disease', 'failure-I-Disease', 'and-O', '10-O', 'normal-O', 'control-O', 'subjects-O', '.-O']
['Serum-O', 'levels-O', 'of-O', 'tumor-B-Disease', 'necrosis-B-Disease', 'factor-O', ',-O', 'alpha-O', 'and-O', 'interferon-O', ',-O', 'gamma-O', 'were-O', 'also-O', 'determined-O', 'by-O', 'ELISA-O', '.-O']
['RESULTS-O', ':-O', 'Serum-O', 'sFas-B-Chemical', 'was-O', 'significantly-O', 'increased-O', 'in-O', 'patients-O', 'with-O', 'acute-B-Disease', 'liver-I-Disease', 'failure-I-Disease', '(-O', 'median-O', ',-O', '26-O', '.-O']
['8-O', 'U-O', '/-O', 'mL-O', ';-O', 'range-O', ',-O', '6-O', '.-O']
['9-O', ',-O', '52-O', '.-O']
['7-O', 'U-O', '/-O', 'mL-O', ')-O', 'compared-O', 'to-O', 'the-O', 'normal-O', 'controls-O', '(-O', 'median-O', ',-O', '8-O', '.-O']
['6-O', 'U-O', '/-O', 'mL-O', ';-O', 'range-O', ',-O', '6-O', '.-O']
['5-O', ',-O', '12-O', '.-O']
['0-O', 'U-O', '/-O', 'mL-O', ',-O', 'P-O', '<-O', '0-O', '.-O']
['0001-O', ').-O', 'Levels-O', 'were-O', 'significantly-O', 'greater-O', 'in-O', 'patients-O', 'with-O', 'acute-B-Disease', 'liver-O', 'failure-I-Disease', 'due-O', 'to-O', 'paracetamol-B-Chemical', 'overdose-B-Disease', '(-O', 'median-O', ',-O', '28-O', '.-O']
['7-O', 'U-O', '/-O', 'mL-O', ';-O', 'range-O', ',', '12-O', '.-O']
['8-O', ',-O', '52-O', '.-O']
['7-O', 'U-O', '/-O', 'mL-O', ',-O', 'n-O', '=-O', '17-O', ')-O', 'than-O', 'those-O', 'due-O', 'to-O', 'non-O', ',-O', 'A-O', 'to-O', 'E-O', 'hepatitis-B-Disease', '(-O', 'median-O', ',-O', '12-O', '.-O']
['5-O', 'U-O', '/-O', 'mL-O', ';-O', 'range-O', ',-O', '6-O', '.-O']
['9-O', ',-O', '46-O', '.-O']
['0-O', 'U-O', '/-O', 'mL-O', ',-O', 'n-O', '=-O', '7-O', ',-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'There-O', 'was-O', 'no-O', 'relationship-O', 'of-O', 'sFas-B-Chemical', 'to-O', 'eventual-O', 'outcome-O', 'in-O', 'the-O', 'patients-O', '.-O']
['A-O', 'significant-O', 'correlation-O', 'was-O', 'observed-O', 'between-O', 'serum-O', 'sFas-B-Chemical', 'levels-O', 'and-O', 'aspartate-B-Chemical', 'aminotransferase-O', '(-O', 'r-O', '=', '0-O', '.-O']
['613-O', ',-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'CONCLUSIONS-O', ':-O', 'The-O', 'increased-O', 'concentration-O', 'of-O', 'sFas-B-Chemical', 'in-O', 'serum-O', 'of-O', 'patients-O', 'with-O', 'acute-B-Disease', 'liver-B-Disease', 'failure-I-Disease', 'may-O', 'reflect-O', 'activation-O', 'of-O', 'Fas-B-Chemical', ',-O', 'mediated-O', 'apoptosis-O', 'in-O', 'the-O', 'liver-O', 'and-O', 'this-O', 'together-O', 'with-O', 'increased-O', 'tumor-B-Disease', 'necrosis-I-Disease']
['Bilateral-O', 'subthalamic-O', 'nucleus-O', 'stimulation-O', 'for-O', 'Parkinson-B-Disease', 'disease-I-Disease', '.-O']
['High-O', 'frequency-O', 'stimulation-O', 'of-O', 'the-O', 'subthalamic-O', 'nucleus-O', '(-O', 'STN-O', ')-O', 'is-O', 'known-O', 'to-O', 'ameliorate-O', 'the-O', 'signs-O', 'and-O', 'symptoms-O', 'of-O', 'advanced-O', 'Parkinson-B-Disease', 'disease-I-Disease', '.-O']
['AIM-O', ':-O', 'We-O', 'studied-O', 'the-O', 'effect-O', 'of-O', 'high-O', 'frequency-O', 'STN-O', 'stimulation-O', 'in-O', '23-O', 'patients-O', '.-O']
['METHOD-O', ':-O', 'Twenty-O', ',-O', 'three-O', 'patients-O', 'suffering-O', 'from-O', 'severe-O', 'Parkinson-B-Disease', 'disease-I-Disease', '(-O', 'Stages-O', 'III-O', ',-O', 'V-O', 'on-O', 'Hoehn-O', 'and-O', 'Yahr-O', 'scale-O', ')-O', 'and-O', ',-O', 'particularly-O', 'bradykinesia-B-Disease', ',-O', 'rigidity-B-Disease', ',-O', 'and-O', 'levodopa-B-Chemical', ',-O', 'induced-O', 'dyskinesias-B-Disease', 'underwent-O', 'bilateral-O', 'implantation-O', 'of-O', 'electrodes-O', 'in-O', 'the-O', 'STN-O', '.-O']
['Preoperative-O', 'and-O', 'postoperative-O', 'assessments-O', 'of-O', 'these-O', 'patients-O', 'at-O', '1-O', ',-O', '3-O', ',-O', '6-O', 'and-O', '12-O', 'months-O', 'follow-O', ',-O', 'up-O', ',-O', 'in-O', 'x-O', 'on-O', 'x-O', 'and-O', 'x-O', 'off-O', 'x-O', 'drug-O', 'conditions-O', ',-O', 'was-O', 'carried-O', 'out-O', 'using-O', 'Unified-O', 'Parkinson-O', 'Disease-O', 'Rating-O', 'Scale-O', ',-O', 'Hoehn-O', 'and-O', 'Yahr-O', 'staging-O', ',-O', 'England-O', 'activities-O', 'of-O', 'daily-O', 'living-O', 'score-O', 'and-O', 'video-O', 'recordings-O', '.-O']
['RESULTS-O', ':-O', 'After-O', 'one-O', 'year-O', 'of-O', 'electrical-O', 'stimulation-O', 'of-O', 'the-O', 'STN-O', ',-O', 'the-O', 'patients-O', 'x-O', 'scores-O', 'for-O', 'activities-O', 'of-O', 'daily-O', 'living-O', 'and-O', 'motor-O', 'examination-O', 'scores-O', '(-O', 'Unified-O', 'Parkinson-O', 'Disease-O', 'Rating-O', 'Scale-O', 'parts-O', 'II-O', 'and-O', 'III-O', ')-O', 'off-O', 'medication-O', 'improved-O', 'by-O', '62-O', '%-O', 'and-O', '61-O', '%-O', 'respectively-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['0005-O', ').-O', 'The-O', 'subscores-O', 'for-O', 'the-O', 'akinesia-B-Disease', ',-O', 'rigidity-B-Disease', ',-O', 'tremor-B-Disease', 'and-O', 'gait-O', 'also-O', 'improved-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['0005-O', ')-O', 'The-O', 'average-O', 'levodopa-B-Chemical', 'dose-O', 'decreased-O', 'from-O', '813-O', 'mg-O', 'to-O', '359-O', 'mg-O', '.-O']
['The-O', 'cognitive-O', 'functions-O', 'remained-O', 'unchanged-O', '.-O']
['Two-O', 'patients-O', 'developed-O', 'device-O', ',-O', 'related-O', 'complications-O', 'and-O', 'two-O', 'patients-O', 'experienced-O', 'abnormal-O', 'weight-O', 'gain-O', '.-O']
['CONCLUSION-O', ':-O', 'Bilateral-O', 'subthalamic-O', 'nucleus-O', 'stimulation-O', 'is-O', 'an-O', 'effective-O', 'treatment-O', 'for-O', 'advanced-O', 'Parkinson-B-Disease', 'disease-I-Disease', '.-O']
['It-O', 'reduces-O', 'the-O', 'severity-O', 'of-O', 'x-O', 'off-O', 'x-O', 'phase-O', 'symptoms-O', ',-O', 'improves-O', 'the-O', 'axial-O', 'symptoms-O', 'and-O', 'reduces-O', 'levodopa-B-Chemical', 'requirements-O', '.-O']
['The-O', 'reduction-O', 'in-O', 'the-O', 'levodopa-B-Chemical', 'dose-O', 'is-O', 'useful-O', 'in-O', 'controlling-O', 'drug-induced-O', 'dyskinesias-B-Disease']
['Ocular-B-Disease', 'motility-O', 'changes-O', 'after-O', 'subtenon-O', 'carboplatin-B-Chemical', 'chemotherapy-O', 'for-O', 'retinoblastoma-B-Disease', '.-O']
['BACKGROUND-O', ':-O', 'Focal-O', 'subtenon-O', 'carboplatin-B-Chemical', 'injections-O', 'have-O', 'recently-O', 'been-O', 'used-O', 'as-O', 'a-O', 'presumably-O', 'toxicity-O', ',-O', 'free-O', 'adjunct-O', 'to-O', 'systemic-O', 'chemotherapy-O', 'for-O', 'intraocular-O', 'retinoblastoma-B-Disease', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'report-O', 'our-O', 'clinical-O', 'experience-O', 'with-O', 'abnormal-O', 'ocular-B-Disease', 'motility-O', 'in-O', 'patients-O', 'treated-O', 'with-O', 'subtenon-O', 'carboplatin-B-Chemical', 'chemotherapy-O', '.-O']
['METHODS-O', ':-O', 'We-O', 'noted-O', 'abnormal-O', 'ocular-B-Disease', 'motility-O', 'in-O', '10-O', 'consecutive-O', 'patients-O', 'with-O', 'retinoblastoma-B-Disease', 'who-O', 'had-O', 'received-O', 'subtenon-O', 'carboplatin-B-Chemical', '.-O']
['During-O', 'ocular-B-Disease', 'manipulation-O', 'under-O', 'general-O', 'anesthesia-O', ',-O', 'we-O', 'assessed-O', 'their-O', 'eyes-O', 'by-O', 'forced-O', 'duction-O', 'testing-O', ',-O', 'comparing-O', 'ocular-B-Disease', 'motility-O', 'after-O', 'tumor-B-Disease', 'control-O', 'with-O', 'ocular-B-Disease', 'motility-O', 'at-O', 'diagnosis-O', '.-O']
['Eyes-O', 'subsequently-O', 'enucleated-O', 'because-O', 'of-O', 'treatment-O', 'failure-O', '(-O', 'n-O', '=', '4-O', ')-O', 'were-O', 'examined-O', 'histologically-O', '.-O']
['RESULTS-O', ':-O', 'Limitation-O', 'of-O', 'ocular-B-Disease', 'motility-O', 'was-O', 'detected-O', 'in-O', 'all-O', '12-O', 'eyes-O', 'of-O', '10-O', 'patients-O', 'treated-O', 'for-O', 'intraocular-O', 'retinoblastoma-B-Disease', 'with-O', '1-O', 'to-O', '6-O', 'injections-O', 'of-O', 'subtenon-O', 'carboplatin-B-Chemical', 'as-O', 'part-O', 'of-O', 'multimodality-O', 'therapy-O', '.-O']
['Histopathological-O', 'examination-O', 'revealed-O', 'many-O', 'lipophages-O', 'in-O', 'the-O', 'periorbital-O', 'fat-O', 'surrounding-O', 'the-O', 'optic-O', 'nerve-O', 'in-O', '1-O', 'eye-O', ',-O', 'indicative-O', 'of-O', 'phagocytosis-O', 'of-O', 'previously-O', 'existing-O', 'fat-O', 'cells-O', 'and-O', 'suggesting-O', 'prior-O', 'fat-O', 'necrosis-B-Disease', '.-O']
['The-O', 'enucleations-O', 'were-O', 'technically-O', 'difficult-O', 'and-O', 'hazardous-O', 'for-O', 'globe-O', 'rupture-O', 'because-O', 'of-O', 'extensive-O', 'orbital-O', 'soft-O', 'tissue-O', 'adhesions-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Subtenon-O', 'carboplatin-B-Chemical', 'chemotherapy-O', 'is-O', 'associated-O', 'with-O', 'significant-O', 'fibrosis-B-Disease', 'of-O', 'orbital-O', 'soft-O', 'tissues-O', ',-O', 'leading-O', 'to-O', 'mechanical-O', 'restriction-O', 'of-O', 'eye-O', 'movements-O', 'and-O', 'making-O', 'subsequent-O', 'enucleation-O', 'difficult-O', '.-O']
['Subtenon-O', 'carboplatin-B-Chemical', 'is-O', 'not-O', 'free-O', 'of-O', 'toxicity-B-Disease']
['Ethambutol-B-Chemical', 'and-O', 'optic-B-Disease', 'neuropathy-I-Disease', '.-O']
['PURPOSE-O', ':-O', 'To-O', 'demonstrate-O', 'the-O', 'association-O', 'between-O', 'ethambutol-B-Chemical', 'and-O', 'optic-B-Disease', 'neuropathy-I-Disease', '.-O']
['METHOD-O', ':-O', 'Thirteen-O', 'patients-O', 'who-O', 'developed-O', 'optic-B-Disease', 'neuropathy-I-Disease', 'after-O', 'being-O', 'treated-O', 'with-O', 'ethambutol-B-Chemical', 'for-O', 'tuberculosis-B-Disease', 'of-O', 'the-O', 'lung-O', 'or-O', 'lymph-O', 'node-O', 'at-O', 'Siriraj-O', 'Hospital-O', 'between-O', '1997-O', 'and-O', '2001-O', 'were-O', 'retrospectively-O', 'reviewed-O', '.-O']
['The-O', 'clinical-O', 'characteristics-O', 'and-O', 'initial-O', 'and-O', 'final-O', 'visual-O', 'acuity-O', 'were-O', 'analyzed-O', 'to-O', 'determine-O', 'visual-O', 'outcome-O', '.-O']
['RESULTS-O', ':-O', 'All-O', 'patients-O', 'had-O', 'optic-B-Disease', 'neuropathy-I-Disease', 'between-O', '1-O', 'to-O', '6-O', 'months-O', '(-O', 'mean-O', '='-O', '2-O', '.-O']
['9-O', 'months-O', ')-O', 'after-O', 'starting-O', 'ethambutol-B-Chemical', 'therapy-O', 'at-O', 'a-O', 'dosage-O', 'ranging-O', 'from-O', '13-O', 'to-O', '20-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', '(-O', 'mean-O', '=', '17-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', ')-O', 'Seven-O', '(-O', '54-O', ')-O', 'of-O', 'the-O', '13-O', 'patients-O', 'experienced-O', 'visual-B-Disease', 'recovery-O', 'after-O', 'stopping-O', 'the-O', 'drug-O', '.-O']
['Of-O', '6-O', 'patients-O', 'with-O', 'irreversible-O', 'visual-B-Disease', 'impairment-I-Disease', ',-O', '4-O', 'patients-O', 'had-O', 'diabetes-B-Disease', 'mellitus-I-Disease', ',-O', 'glaucoma-B-Disease', 'and-O', 'a-O', 'history-O', 'of-O', 'heavy-O', 'smoking-B-Chemical', '.-O']
['CONCLUSION-O', ':-O', 'Early-O', 'recognition-O', 'of-O', 'optic-B-Disease', 'neuropathy-I-Disease', 'should-O', 'be-O', 'considered-O', 'in-O', 'patients-O', 'with-O', 'ethambutol-B-Chemical', 'therapy-O', '.-O']
['A-O', 'low-O', 'dose-O', 'and-O', 'prompt-O', 'discontinuation-O', 'of-O', 'the-O', 'drug-O', 'is-O', 'recommended-O', 'particularly-O', 'in-O', 'individuals-O', 'with-O', 'diabetes-B-Disease', 'mellitus-I-Disease', ',-O', 'glaucoma-B-Disease']
['Treatment-O', 'of-O', 'compensatory-O', 'gustatory-O', 'hyperhidrosis-B-Disease', 'with-O', 'topical-O', 'glycopyrrolate-B-Chemical', '.-O']
['Gustatory-B-Disease', 'hyperhidrosis-B-Disease', 'is-O', 'facial-O', 'sweating-O', 'usually-O', 'associated-O', 'with-O', 'the-O', 'eating-O', 'of-O', 'hot-O', 'spicy-O', 'food-O', 'or-O', 'even-O', 'smelling-O', 'this-O', 'food-O', '.-O']
['Current-O', 'options-O', 'of-O', 'treatment-O', 'include-O', 'oral-O', 'anticholinergic-O', 'drugs-O', ',-O', 'the-O', 'topical-O', 'application-O', 'of-O', 'anticholinergics-O', 'or-O', 'aluminum-B-Chemical', 'chloride-I-Chemical', ',-O', 'and-O', 'the-O', 'injection-O', 'of-O', 'botulinum-B-Chemical', 'toxin-B-Chemical', '.-O']
['Thirteen-O', 'patients-O', 'have-O', 'been-O', 'treated-O', 'to-O', 'date-O', 'with-O', '1-O', '.-O']
['5-O', '%-O', 'or-O', '2-O', '%-O', 'topical-O', 'glycopyrrolate-B-Chemical', '.-O']
['All-O', 'patients-O', 'had-O', 'gustatory-B-Disease', 'hyperhidrosis-B-Disease', ',-O', 'which-O', 'interfered-O', 'with-O', 'their-O', 'social-O', 'activities-O', ',-O', 'after-O', 'transthroacic-O', 'endoscopic-O', 'sympathectomy-O', ',-O', 'and-O', 'which-O', 'was-O', 'associated-O', 'with-O', 'compensatory-O', 'focal-O', 'hyperhidrosis-B-Disease', '.-O']
['After-O', 'applying-O', 'topical-O', 'glycopyrrolate-B-Chemical', ',-O', 'the-O', 'subjective-O', 'effect-O', 'was-O', 'excellent-O', '(-O', 'no-O', 'sweating-O', 'after-O', 'eating-O', 'hot-O', 'spicy-O', 'food-O', ')-O', 'in-O', '10-O', 'patients-O', '(-O', '77-O', ')-O', 'and-O', 'fair-O', '(-O', 'clearly-O', 'reduced-O', 'sweating-O', ')-O', 'in-O', '3-O', 'patients-O', '(-O', '23-O', ')-O', '.-O', 'All-O', 'had-O', 'reported-O', 'incidents-O', 'of-O', 'being-O', 'very-O', 'embarrassed-O', 'whilst-O', 'eating-O', 'hot-O', 'spicy-O', 'foods-O', '.-O']
['Adverse-O', 'effects-O', 'included-O', 'a-O', 'mildly-O', 'dry-B-Disease', 'mouth-I-Disease', 'and-O', 'a-O', 'sore-B-Disease', 'throat-I-Disease', 'in-O', '2-O', 'patients-O', '(-O', '2-O', '%-O', 'glycopyrrolate-B-Chemical', '),-O', 'a-O', 'light-O', 'headache-B-Disease', 'in-O', '1-O', 'patient-O', '(-O', '1-O', '.-O']
['5-O', '%-O', 'glycopyrrolate-B-Chemical', ').-O', 'The-O', 'topical-O', 'application-O', 'of-O', 'a-O', 'glycopyrrolate-B-Chemical', 'pad-O', 'appeared-O', 'to-O', 'be-O', 'safe-O', ',-O', 'efficacious-O', ',-O', 'well-O', 'tolerated-O', ',-O', 'and-O', 'a-O', 'convenient-O', 'method-O', 'of-O', 'treatment-O', 'for-O', 'moderate-O', 'to-O', 'severe-O', 'symptoms-O', 'of-O', 'gustatory-O', 'hyperhidrosis-B-Disease']
['Pharmacological-O', 'characteristics-O', 'and-O', 'side-O', 'effects-O', 'of-O', 'a-O', 'new-O', 'galenic-O', 'formulation-O', 'of-O', 'propofol-B-Chemical', 'without-O', 'soyabean-O', 'oil-O', '.-O']
['We-O', 'compared-O', 'the-O', 'pharmacokinetics-O', ',-O', 'pharmacodynamics-O', 'and-O', 'safety-O', 'profile-O', 'of-O', 'a-O', 'new-O', 'galenic-O', 'formulation-O', 'of-O', 'propofol-B-Chemical', '(-O', 'AM149-O', '1-O', '),', 'which-O', 'does-O', 'not-O', 'contain-O', 'soyabean-O', 'oil-O', ',-O', 'with-O', 'a-O', 'standard-O', 'formulation-O', 'of-O', 'propofol-B-Chemical', '(-O', 'Disoprivan-O', '1-O', ').-O', 'In-O', 'a-O', 'randomised-O', ',-O', 'double-O', ',-O', 'blind-O', ',-O', 'cross-O', ',-O', 'over-O', 'study-O', ',-O', '30-O', 'healthy-O', 'volunteers-O', 'received-O', 'a-O', 'single-O', 'intravenous-O', 'bolus-O', 'injection-O', 'of-O', '2-O', '.-O']
['5-O', 'mg-O', '.-O']
['kg-O', ',-O', '1-O', 'propofol-B-Chemical', '.-O']
['Plasma-O', 'propofol-B-Chemical', 'levels-O', 'were-O', 'measured-O', 'for-O', '48-O', 'h-O', 'following-O', 'drug-O', 'administration-O', 'and-O', 'evaluated-O', 'according-O', 'to-O', 'a-O', 'three-O', ',-O', 'compartment-O', 'model-O', '.-O']
['The-O', 'pharmacodynamic-O', 'parameters-O', 'assessed-O', 'included-O', 'induction-O', 'and-O', 'emergence-O', 'times-O', ',-O', 'respiratory-O', 'and-O', 'cardiovascular-O', 'effects-O', ',-O', 'and-O', 'pain-B-Disease', 'on-O', 'injection-O', '.-O']
['Patients-O', 'were-O', 'monitored-O', 'for-O', 'side-O', 'effects-O', 'over-O', '48-O', 'h-O', '.-O']
['Owing-O', 'to-O', 'a-O', 'high-O', 'incidence-O', 'of-O', 'thrombophlebitis-B-Disease', ',-O', 'the-O', 'study-O', 'was-O', 'terminated-O', 'prematurely-O', 'and-O', 'only-O', 'the-O', 'data-O', 'of-O', 'the-O', 'two-O', 'parallel-O', 'treatment-O', 'groups-O', '(-O', '15-O', 'patients-O', 'in-O', 'each-O', 'group-O', ')-O', 'were-O', 'analysed-O', '.-O']
['Plasma-O', 'concentrations-O', 'did-O', 'not-O', 'differ-O', 'significantly-O', 'between-O', 'the-O', 'two-O', 'formulations-O', '.-O']
['Anaesthesia-O', 'induction-O', 'and-O', 'emergence-O', 'times-O', ',-O', 'respiratory-O', 'and-O', 'cardiovascular-O', 'variables-O', 'showed-O', 'no-O', 'significant-O', 'differences-O', 'between-O', 'the-O', 'two-O', 'treatment-O', 'groups-O', '.-O']
['Pain-B-Disease', 'on-O', 'injection-O', '(-O', '80-O', 'vs-O', '.-O']
['20-O', ',-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'and-O', 'thrombophlebitis-B-Disease', '(-O', '93-O', '.-O']
['3-O', 'vs-O', '.-O']
['6-O', '.-O']
['6-O', ',-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', ')-O', 'occurred-O', 'more-O', 'frequently-O', 'with-O', 'AM149-B-Chemical', 'than-O', 'with-O', 'Disoprivan-B-Chemical', '.-O']
['Although-O', 'both-O', 'formulations-O', 'had-O', 'similar-O', 'pharmacokinetic-O', 'and-O', 'pharmacodynamic-O', 'profiles-O', 'the-O', 'new-O', 'formulation-O', 'is-O', 'not-O', 'suitable-O', 'for-O', 'clinical-O', 'use-O', 'due-O', 'to-O', 'the-O', 'high-O', 'incidence-O', 'of-O', 'thrombophlebitis-B-Disease']
['Vinorelbine-B-Chemical', ',-O', 'related-O', 'cardiac-O', 'events-O', ':-O', 'a-O', 'meta-O', ',-O', 'analysis-O', 'of-O', 'randomized-O', 'clinical-O', 'trials-O', '.-O']
['Several-O', 'cases-O', 'of-O', 'cardiac-O', 'adverse-O', 'reactions-O', 'related-O', 'to-O', 'vinorelbine-B-Chemical', '(-O', 'VNR-O', ')', 'have-O', 'been-O', 'reported-O', 'in-O', 'the-O', 'literature-O', '.-O']
['In-O', 'order-O', 'to-O', 'quantify-O', 'the-O', 'incidence-O', 'of-O', 'these-O', 'cardiac-O', 'events-O', ',-O', 'we-O', 'performed-O', 'a-O', 'meta-O', ',-O', 'analysis-O', 'of-O', 'clinical-O', 'trials-O', 'comparing-O', 'VNR-B-Chemical', 'with-O', 'other-O', 'chemotherapeutic-O', 'agents-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'various-O', 'malignancies-O', '.-O']
['Randomized-O', 'clinical-O', 'trials-O', 'comparing-O', 'VNR-O', 'with-O', 'other-O', 'drugs-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'cancer-B-Disease', 'were-O', 'searched-O', 'in-O', 'Medline-O', ',-O', 'Embase-O', ',-O', 'Evidence-O', ',-O', 'based-O', 'Medicine-O', 'Reviews-O', 'databases-O', 'and-O', 'the-O', 'Cochrane-O', 'library-O', 'from-O', '1987-O', 'to-O', '2002-O', '.-O']
['Outcomes-O', 'of-O', 'interest-O', 'were-O', 'severe-O', 'cardiac-O', 'events-O', ',-O', 'toxic-O', 'deaths-B-Disease', 'and-O', 'cardiac-O', 'event-O', ',-O', 'related-O', 'deaths-B-Disease', 'reported-O', 'in-O', 'each-O', 'publication-O', '.-O']
['We-O', 'found-O', '19-O', 'trials-O', ',-O', 'involving-O', '2441-O', 'patients-O', 'treated-O', 'by-O', 'VNR-B-Chemical', 'and-O', '2050-O', 'control-O', 'patients-O', '.-O']
['The-O', 'incidence-O', 'of-O', 'cardiac-O', 'events-O', 'with-O', 'VNR-B-Chemical', 'was-O', '1-O', '.-O']
['19-O', '%-O', '[O', '95-O', '%-O', 'confidence-O', 'interval-O', '(-O', 'CI-O', ')(-O', '0-O', '.-O']
['75-O', ';-O', '1-O', '.-O']
['67-O', ')-O', '.-O', 'There-O', 'was-O', 'no-O', 'difference-O', 'in-O', 'the-O', 'risk-O', 'of-O', 'cardiac-O', 'events-O', 'between-O', 'VNR-O', 'and-O', 'other-O', 'drugs-O', '[-O', 'odds-O', 'ratio-O', ':-O', '0-O', '.-O']
['92-O', ',-O', '95-O', '%-O', 'CI-O', '(-O', '0-O', '.-O']
['54-O', ';-O', '1-O', '.-O']
['55-O', ')-O', '.-O', 'The-O', 'risk-O', 'of-O', 'VNR-O', 'cardiac-O', 'events-O', 'was-O', 'similar-O', 'to-O', 'vindesine-B-Chemical', '(-O', 'VDS-O', ')-O', 'and-O', 'other-O', 'cardiotoxic-O', 'drugs-O', '[O', 'fluorouracil-B-Chemical', ',-O', 'anthracyclines-B-Chemical', ',-O', 'gemcitabine-B-Chemical', '(-O', 'GEM-O', ')-O', 'em-O', 'leader-O', '].-O', 'Even-O', 'if-O', 'it-O', 'did-O', 'not-O', 'reach-O', 'statistical-O', 'significance-O', 'because-O', 'of-O', 'a-O', 'few-O', 'number-O', 'of-O', 'cases-O', ',-O', 'the-O', 'risk-O', 'was-O', 'lower-O', 'in-O', 'trials-O', 'excluding-O', 'patients-O', 'with-O', 'cardiac-O', 'history-O', ',-O', 'and-O', 'seemed-O', 'to-O', 'be-O', 'higher-O', 'in-O', 'trials-O', 'including-O', 'patients-O', 'with-O', 'pre-O', ',-O', 'existing-O', 'cardiac-O', 'diseases-O', '.-O']
['Vinorelbine-B-Chemical', ',-O', 'related-O', 'cardiac-B-Disease', 'events-O', 'concern-O', 'about-O', '1-O', '%-O', 'of-O', 'treated-O', 'patients-O', 'in-O', 'clinical-O', 'trials-O', '.-O']
['However-O', ',-O', 'the-O', 'risk-O', 'associated-O', 'with-O', 'VNR-B-Disease', '.-O']
['MRI-O', 'findings-O', 'of-O', 'hypoxic-O', 'cortical-O', 'laminar-O', 'necrosis-B-Disease', 'in-O', 'a-O', 'child-O', 'with-O', 'hemolytic-B-Disease', 'anemia-I-Disease', 'crisis-O', '.-O']
['We-O', 'present-O', 'magnetic-O', 'resonance-O', 'imaging-O', 'findings-O', 'of-O', 'a-O', '5-O', ',-O', 'year-O', ',-O', 'old-O', 'girl-O', 'who-O', 'had-O', 'a-O', 'rapidly-O', 'installing-O', 'hemolytic-B-Disease', 'anemia-I-Disease', 'crisis-O', 'induced-O', 'by-O', 'trimethoprim-sulfomethoxazole-B-Chemical', ',-O', 'resulting-O', 'in-O', 'cerebral-O', 'anoxia-B-Disease', 'leading-O', 'to-O', 'permanent-O', 'damage-O', '.-O']
['Magnetic-O', 'Resonance-O', 'imaging-O', 'revealed-O', 'cortical-O', 'laminar-O', 'necrosis-I-Disease', 'in-O', 'arterial-O', 'border-O', 'zones-O', 'in-O', 'both-O', 'cerebral-O', 'hemispheres-O', ',-O', 'ischemic-O', 'changes-O', 'in-O', 'subcortical-O', 'white-O', 'matter-O', 'of-O', 'left-O', 'cerebral-O', 'hemisphere-O', ',-O', 'and-O', 'in-O', 'the-O', 'left-O', 'putamen-O', '.-O']
['Although-O', 'cortical-O', 'laminar-O', 'necrosis-B-Disease']
['The-O', 'natural-O', 'history-O', 'of-O', 'Vigabatrin-B-Chemical', 'associated-O', 'visual-B-Disease', 'field-O', 'defects-I-Disease', 'in-O', 'patients-O', 'electing-O', 'to-O', 'continue-O', 'their-O', 'medication-O', '.-O']
['PURPOSE-O', ':-O', 'To-O', 'determine-O', 'the-O', 'natural-O', 'history-O', 'of-O', 'visual-O', 'field-O', 'defects-O', 'in-O', 'a-O', 'group-O', 'of-O', 'patients-O', 'known-O', 'to-O', 'have-O', 'Vigabatrin-B-Chemical', ',-O', 'associated-O', 'changes-O', 'who-O', 'elected-O', 'to-O', 'continue-O', 'the-O', 'medication-O', 'because-O', 'of-O', 'good-O', 'seizure-O', 'control-O', '.-O']
['METHODS-O', ':-O', 'All-O', 'patients-O', 'taking-O', 'Vigabatrin-B-Chemical', 'alone-O', 'or-O', 'in-O', 'combination-O', 'with-O', 'other-O', 'antiepileptic-O', 'drugs-O', 'for-O', 'at-O', 'least-O', '5-O', 'years-O', '(-O', 'range-O', '5-O', ',-O', '12-O', 'years-O', ')-O', 'were-O', 'entered-O', 'into-O', 'a-O', 'visual-O', 'surveillance-O', 'programme-O', '.-O']
['Patients-O', 'were-O', 'followed-O', 'up-O', 'at-O', '6-O', ',-O', 'monthly-O', 'intervals-O', 'for-O', 'not-O', 'less-O', 'than-O', '18-O', 'months-O', '(-O', 'range-O', '18-O', ',-O', '43-O', 'months-O', ').-O', 'In-O', 'all-O', ',-O', '16-O', 'patients-O', 'with-O', 'unequivocal-O', 'defects-B-Disease', 'continued-O', 'the-O', 'medication-O', '.-O']
['Following-O', 'already-O', 'published-O', 'methodology-O', '(-O', 'Eye-O', '2002-O', ';-O', '16-O', ';-O', '567-O', ',-O', '571-O', ')-O', 'monocular-O', 'mean-O', 'radial-O', 'degrees-O', '(-O', 'MRDs-O', ')-O', 'to-O', 'the-O', 'I-O', '/-O', '4e-O', 'isopter-O', 'on-O', 'Goldmann-O', 'perimetry-O', 'was-O', 'calculated-O', 'for-O', 'the-O', 'right-O', 'eye-O', 'at-O', 'the-O', 'time-O', 'of-O', 'discovery-O', 'of-O', 'a-O', 'visual-O', 'field-O', 'defect-O', 'and-O', 'again-O', 'after-O', 'not-O', 'less-O', 'than-O', '18-O', 'months-O', 'follow-O', ',-O', 'up-O', '.-O']
['RESULTS-O', ':-O', 'Mean-O', 'right-O', 'eye-O', 'MRD-B-Disease', 'at-O', 'presentation-O', 'was-O', '36-O', '.-O']
['98-O', 'degrees-O', '(-O', 'range-O', '22-O', '.-O']
['25-O', ',-O', '51-O', '.-O']
['0-O', ')-O', 'compared-O', 'to-O', '38-O', '.-O']
['40-O', 'degrees-O', '(-O', 'range-O', '22-O', '.-O']
['5-O', ',-O', '49-O', '.-O']
['75-O', ')-O', 'after-O', 'follow-O', ',-O', 'up-O', ';-O', 'P-O', '=', '0-O', '.-O']
['338-O', 'unpaired-O', 't-O', ',-O', 'test-O', '.-O']
['Only-O', 'one-O', 'patient-O', 'demonstrated-O', 'a-O', 'deterioration-O', 'in-O', 'visual-B-Disease', 'field-O', 'during-O', 'the-O', 'study-O', 'period-O', 'and-O', 'discontinued-O', 'treatment-O', '.-O']
['CONCLUSION-O', ':', 'Established-O', 'visual-O', 'field-O', 'defects-B-Disease', 'presumed-O', 'to-O', 'be-O', 'due-O', 'to-O', 'Vigabatrin-B-Chemical', 'therapy-O', 'did-O', 'not-O', 'usually-O', 'progress-O', 'in-O', 'spite-O', 'of-O', 'continuing-O', 'use-O', 'of-O', 'the-O', 'medication-O', '.-O']
['These-O', 'data-O', 'give-O', 'support-O', 'to-O', 'the-O', 'hypothesis-O', 'that-O', 'the-O', 'pathogenesis-O', 'of-O', 'Vigabatrin-B-Chemical', ',-O', 'associated-O', 'visual-O', 'field-O', 'defects-O', 'may-O', 'be-O', 'an-O', 'idiosyncratic-O', 'adverse-B-Disease', 'drug-I-Disease', 'reaction-I-Disease', 'rather-O', 'than-O', 'dose-O', ',-O', 'dependent-O', 'toxicity-O']
['Induction-O', 'of-O', 'rosaceiform-B-Disease', 'dermatitis-I-Disease', 'during-O', 'treatment-O', 'of-O', 'facial-O', 'inflammatory-B-Disease', 'dermatoses-I-Disease', 'with-O', 'tacrolimus-B-Chemical', 'ointment-O', '.-O']
['BACKGROUND-O', ':-O', 'Tacrolimus-B-Chemical', 'ointment-O', 'is-O', 'increasingly-O', 'used-O', 'for-O', 'anti-O', ',-O', 'inflammatory-O', 'treatment-O', 'of-O', 'sensitive-O', 'areas-O', 'such-O', 'as-O', 'the-O', 'face-O', ',-O', 'and-O', 'recent-O', 'observations-O', 'indicate-O', 'that-O', 'the-O', 'treatment-O', 'is-O', 'effective-O', 'in-O', 'steroid-O', ',-O', 'aggravated-O', 'rosacea-B-Disease', 'and-O', 'perioral-O', 'dermatitis-B-Disease', '.-O']
['We-O', 'report-O', 'on-O', 'rosaceiform-B-Disease', 'dermatitis-I-Disease', 'as-O', 'a-O', 'complication-O', 'of-O', 'treatment-O', 'with-O', 'tacrolimus-B-Chemical', 'ointment-O', '.-O']
['OBSERVATIONS-O', ':-O', 'Six-O', 'adult-O', 'patients-O', 'with-O', 'inflammatory-O', 'facial-O', 'dermatoses-B-Disease', 'were-O', 'treated-O', 'with-O', 'tacrolimus-B-Chemical', 'ointment-O', 'because-O', 'of-O', 'the-O', 'ineffectiveness-O', 'of-O', 'standard-O', 'treatments-O', '.-O']
['Within-O', '2-O', 'to-O', '3-O', 'weeks-O', 'of-O', 'initially-O', 'effective-O', 'and-O', 'well-O', ',-O', 'tolerated-O', 'treatment-O', ',-O', '3-O', 'patients-O', 'with-O', 'a-O', 'history-O', 'of-O', 'rosacea-B-Disease', 'and-O', '1-O', 'with-O', 'a-O', 'history-O', 'of-O', 'acne-B-Disease', 'experienced-O', 'sudden-O', 'worsening-O', 'with-O', 'pustular-O', 'rosaceiform-O', 'lesions-O', '.-O']
['Biopsy-O', 'revealed-O', 'an-O', 'abundance-O', 'of-O', 'Demodex-B-Disease', 'mites-O', 'in-O', '2-O', 'of-O', 'these-O', 'patients-O', '.-O']
['In-O', '1-O', 'patient-O', 'with-O', 'eyelid-O', 'eczema-B-Disease', ',-O', 'rosaceiform-O', 'periocular-O', 'dermatitis-B-Disease', 'gradually-O', 'appeared-O', 'after-O', '3-O', 'weeks-O', 'of-O', 'treatment-O', '.-O']
['In-O', '1-O', 'patient-O', 'with-O', 'atopic-O', 'dermatitis-B-Disease', ',-O', 'telangiectatic-O', 'and-O', 'papular-O', 'rosacea-B-Disease', 'insidiously-O', 'appeared-O', 'after-O', '5-O', 'months-O', 'of-O', 'treatment-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Our-O', 'observations-O', 'suggest-O', 'that-O', 'the-O', 'spectrum-O', 'of-O', 'rosaceiform-B-Disease', 'dermatitis-I-Disease', 'as-O', 'a-O', 'complication-O', 'of-O', 'treatment-O', 'with-O', 'tacrolimus-B-Chemical', 'ointment-O', 'is-O', 'heterogeneous-O', '.-O']
['A-O', 'variety-O', 'of-O', 'factors-O', ',-O', 'such-O', 'as-O', 'vasoactive-O', 'properties-O', 'of-O', 'tacrolimus-B-Chemical']
['Structural-O', 'abnormalities-I-Disease', 'in-O', 'the-O', 'brains-O', 'of-O', 'human-O', 'subjects-O', 'who-O', 'use-O', 'methamphetamine-B-Chemical', '.-O']
['We-O', 'visualize-O', ',-O', 'for-O', 'the-O', 'first-O', 'time-O', ',-O', 'the-O', 'profile-O', 'of-O', 'structural-B-Disease', 'deficits-I-Disease', 'in-O', 'the-O', 'human-O', 'brain-O', 'associated-O', 'with-O', 'chronic-O', 'methamphetamine-B-Disease', '(-O', 'MA-O', ')-O', 'abuse-I-Disease', '.-O']
['Studies-O', 'of-O', 'human-O', 'subjects-O', 'who-O', 'have-O', 'used-O', 'MA-B-Chemical', 'chronically-O', 'have-O', 'revealed-O', 'deficits-O', 'in-O', 'dopaminergic-O', 'and-O', 'serotonergic-O', 'systems-O', 'and-O', 'cerebral-O', 'metabolic-O', 'abnormalities-I-Disease', '.-O']
['Using-O', 'magnetic-O', 'resonance-O', 'imaging-O', '(-O', 'MRI-O', ')-O', 'and-O', 'new-O', 'computational-O', 'brain-O', ',-O', 'mapping-O', 'techniques-O', ',-O', 'we-O', 'determined-O', 'the-O', 'pattern-O', 'of-O', 'structural-O', 'brain-O', 'alterations-O', 'associated-O', 'with-O', 'chronic-O', 'MA-B-Chemical', 'abuse-O', 'in-O', 'human-O', 'subjects-O', 'and-O', 'related-O', 'these-O', 'deficits-O', 'to-O', 'cognitive-O', 'impairment-O', '.-O']
['We-O', 'used-O', 'high-O', ',-O', 'resolution-O', 'MRI-O', 'and-O', 'surface-O', ',-O', 'based-O', 'computational-O', 'image-O', 'analyses-O', 'to-O', 'map-O', 'regional-O', 'abnormalities-O', 'in-O', 'the-O', 'cortex-O', ',-O', 'hippocampus-O', ',-O', 'white-O', 'matter-O', ',-O', 'and-O', 'ventricles-O', 'in-O', '22-O', 'human-O', 'subjects-O', 'who-O', 'used-O', 'MA-B-Chemical', 'and-O', '21-O', 'age-O', ',-O', 'matched-O', ',-O', 'healthy-O', 'controls-O', '.-O']
['Cortical-O', 'maps-O', 'revealed-O', 'severe-O', 'gray-O', 'matter-O', 'deficits-O', 'in-O', 'the-O', 'cingulate-O', ',-O', 'limbic-O', ',-O', 'and-O', 'paralimbic-O', 'cortices-O', 'of-O', 'MA-B-Chemical', 'abusers-O', '(-O', 'averaging-O', '11-O', '.-O']
['3-O', '%-O', 'below-O', 'control-O', ';-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'On-O', 'average-O', ',-O', 'MA-O', 'abusers-O', 'had-O', '7-O', '.-O']
['8-O', '%-O', 'smaller-O', 'hippocampal-O', 'volumes-O', 'than-O', 'control-O', 'subjects-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ';-O', 'left-O', ',-O', 'p-O', '=O', '0-O', '.-O']
['01-O', ';-O', 'right-O', ',-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ')-O', 'and-O', 'significant-O', 'white-B-Disease', ',', 'matter-I-Disease', 'hypertrophy-I-Disease', '(-O', '7-O', '.-O']
['0-O', ';-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'Hippocampal-O', 'deficits-B-Disease', 'were-O', 'mapped-O', 'and-O', 'correlated-O', 'with-O', 'memory-O', 'performance-O', 'on-O', 'a-O', 'word-O', ',-O', 'recall-O', 'test-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'MRI-O', ',-O', 'based-O', 'maps-O', 'suggest-O', 'that-O', 'chronic-O', 'methamphetamine-B-Chemical', 'abuse-O', 'causes-O', 'a-O', 'selective-O', 'pattern-O', 'of-O', 'cerebral-O', 'deterioration-O', 'that-O', 'contributes-O', 'to-O', 'impaired-O', 'memory-B-Disease', 'performance-O', '.-O']
['MA-B-Chemical', 'may-O', 'selectively-O', 'damage-O', 'the-O', 'medial-O', 'temporal-O', 'lobe-O', 'and-O', ',-O', 'consistent-O', 'with-O', 'metabolic-O', 'studies-O', ',-O', 'the-O', 'cingulate-O', ',-O', 'limbic-O', 'cortex-O', ',-O', 'inducing-O', 'neuroadaptation-O', ',-O', 'neuropil-O', 'reduction-O', ',-O', 'or-O', 'cell-O', 'death-O', '.-O']
['Prominent-O', 'white-B-Disease', ',', 'matter-I-Disease', 'hypertrophy-I-Disease', 'may-O', 'result-O', 'from-O', 'altered-O', 'myelination-O', 'and-O', 'adaptive-O', 'glial-O', 'changes-O', ',-O', 'including-O', 'gliosis-B-Disease', 'secondary-O', 'to-O', 'neuronal-O', 'damage-O', '.-O']
['These-O', 'brain-O', 'substrates-O', 'may-O', 'help-O', 'account-O', 'for-O', 'the-O', 'symptoms-O', 'of-O', 'MA-B-Disease', 'abuse-I-Disease', ',-O', 'providing-O', 'therapeutic-O', 'targets-O', 'for-O', 'drug-B-Chemical', ',-O', 'induced-O', 'brain-O', 'injury-I-Disease']
['Disruption-O', 'of-O', 'hepatic-O', 'lipid-O', 'homeostasis-O', 'in-O', 'mice-O', 'after-O', 'amiodarone-B-Chemical', 'treatment-O', 'is-O', 'associated-O', 'with-O', 'peroxisome-O', 'proliferator-O', ',-O', 'activated-O', 'receptor-O', ',-O', 'alpha-O', 'target-O', 'gene-O', 'activation-O', '.-O']
['Amiodarone-B-Chemical', ',-O', 'an-O', 'efficacious-O', 'and-O', 'widely-O', 'used-O', 'antiarrhythmic-O', 'agent-O', ',-O', 'has-O', 'been-O', 'reported-O', 'to-O', 'cause-O', 'hepatotoxicity-B-Disease', 'in-O', 'some-O', 'patients-O', '.-O']
['To-O', 'gain-O', 'insight-O', 'into-O', 'the-O', 'mechanism-O', 'of-O', 'this-O', 'unwanted-O', 'effect-O', ',-O', 'mice-O', 'were-O', 'administered-O', 'various-O', 'doses-O', 'of-O', 'amiodarone-B-Chemical', 'and-O', 'examined-O', 'for-O', 'changes-O', 'in-O', 'hepatic-O', 'histology-O', 'and-O', 'gene-O', 'regulation-O', '.-O']
['Amiodarone-B-Chemical', 'induced-O', 'hepatomegaly-B-Disease', ',-O', 'hepatocyte-O', 'microvesicular-O', 'lipid-O', 'accumulation-O', ',-O', 'and-O', 'a-O', 'significant-O', 'decrease-O', 'in-O', 'serum-O', 'triglycerides-O', 'and-O', 'glucose-B-Chemical', '.-O']
['Northern-O', 'blot-O', 'analysis-O', 'of-O', 'hepatic-O', 'RNA-O', 'revealed-O', 'a-O', 'dose-O', ',-O', 'dependent-O', 'increase-O', 'in-O', 'the-O', 'expression-O', 'of-O', 'a-O', 'number-O', 'of-O', 'genes-O', 'critical-O', 'for-O', 'fatty-O', 'acid-O', 'oxidation-O', ',-O', 'lipoprotein-O', 'assembly-O', ',-O', 'and-O', 'lipid-O', 'transport-O', '.-O']
['Many-O', 'of-O', 'these-O', 'genes-O', 'are-O', 'regulated-O', 'by-O', 'the-O', 'peroxisome-O', 'proliferator-O', ',-O', 'activated-O', 'receptor-O', ',-O', 'alpha-O', '(-O', 'PPARalpha-O', ')-O', 'a-O', 'ligand-O', ',-O', 'activated-O', 'nuclear-O', 'hormone-O', 'receptor-O', 'transcription-O', 'factor-O', '.-O']
['The-O', 'absence-O', 'of-O', 'induction-O', 'of-O', 'these-O', 'genes-O', 'as-O', 'well-O', 'as-O', 'hepatomegaly-B-Disease', 'in-O', 'PPARalpha-O', 'knockout-O', '[', 'PPARalpha-O', '-/-]-O', 'mice-O', 'indicated-O', 'that-O', 'the-O', 'effects-O', 'of-O', 'amiodarone-B-Chemical', 'were-O', 'dependent-O', 'upon-O', 'the-O', 'presence-O', 'of-O', 'a-O', 'functional-O', 'PPARalpha-O', 'gene-O', '.-O']
['Compared-O', 'to-O', 'wild-O', ',-O', 'type-O', 'mice-O', ',-O', 'treatment-O', 'of-O', 'PPARalpha-O', '-/-O', 'mice-O', 'with-O', 'amiodarone-B-Chemical', 'resulted-O', 'in-O', 'an-O', 'increased-O', 'rate-O', 'and-O', 'extent-O', 'of-O', 'total-O', 'body-O', 'weight-O', 'loss-O', '.-O']
['The-O', 'inability-O', 'of-O', 'amiodarone-B-Chemical', 'to-O', 'directly-O', 'activate-O', 'either-O', 'human-O', 'or-O', 'mouse-O', 'PPARalpha-O', 'transiently-O', 'expressed-O', 'in-O', 'human-O', 'HepG2-O', 'hepatoma-O', 'cells-O', 'indicates-O', 'that-O', 'the-O', 'effects-O', 'of-O', 'amiodarone-B-Chemical', 'on-O', 'the-O', 'function-O', 'of-O', 'this-O', 'receptor-O', 'were-O', 'indirect-O', '.-O']
['Based-O', 'upon-O', 'these-O', 'results-O', ',-O', 'we-O', 'conclude-O', 'that-O', 'amiodarone-B-Chemical', 'disrupts-O', 'hepatic-O', 'lipid-O', 'homeostasis-O', 'and-O', 'that-O', 'the-O', 'increased-O', 'expression-O', 'of-O', 'PPARalpha-O', 'target-O', 'genes-O', 'is-O', 'secondary-O', 'to-O', 'this-O', 'toxic-O', 'effect-O', '.-O']
['These-O', 'results-O', 'provide-O', 'important-O', 'new-O', 'mechanistic-O', 'information-O', 'regarding-O', 'the-O', 'hepatotoxic-B-Disease', 'effects-O', 'of-O', 'amiodarone-B-Chemical', 'and-O', 'indicate-O', 'that-O', 'PPARalpha-O', 'protects-O', 'against-O', 'amiodarone-B-Chemical', ',-O', 'induced-O', 'hepatotoxicity-B-Disease']
['Safety-O', 'and-O', 'compliance-O', 'with-O', 'once-O', ',-O', 'daily-O', 'niacin-B-Chemical', 'extended-release/Olovastatin-B-Chemical', 'as-O', 'initial-O', 'therapy-O', 'in-O', 'the-O', 'Impact-O', 'of-O', 'Medical-O', 'Subspecialty-O', 'on-O', 'Patient-O', 'Compliance-O', 'to-O', 'Treatment-O', '(-O', 'IMPACT-O', ')-O', 'study-O', '.-O']
['Niacin-B-Chemical', 'extended-release/lovastatin-B-Chemical', 'is-O', 'a-O', 'new-O', 'combination-O', 'product-O', 'approved-O', 'for-O', 'treatment-O', 'of-O', 'primary-O', 'hypercholesterolemia-B-Disease', 'and-O', 'mixed-O', 'dyslipidemia-B-Disease', '.-O']
['This-O', 'open-O', ',-O', 'labeled-O', ',-O', 'multicenter-O', 'study-O', 'evaluated-O', 'the-O', 'safety-O', 'of-O', 'bedtime-O', 'niacin-B-Chemical', 'extended-release/lovastatin-B-Chemical', 'when-O', 'dosed-O', 'as-O', 'initial-O', 'therapy-O', 'and-O', 'patient-O', 'compliance-O', 'to-O', 'treatment-O', 'in-O', 'various-O', 'clinical-O', 'practice-O', 'settings-O', '.-O']
['A-O', 'total-O', 'of-O', '4-O', ',', '499-O', 'patients-O', 'with-O', 'dyslipidemia-B-Disease', 'requiring-O', 'drug-O', 'intervention-O', 'was-O', 'enrolled-O', 'at-O', '1-O', ',', '081-O', 'sites-O', '.-O']
['Patients-O', 'were-O', 'treated-O', 'with-O', '1-O', 'tablet-O', '(-O', '500-O', 'mg-O', 'of-O', 'niacin-B-Chemical', 'extended-O', ',-O', 'release-O', '/', '20-O', 'mg-O', 'of-O', 'lovastatin-B-Chemical', ')-O', 'once-O', 'nightly-O', 'for-O', '4-O', 'weeks-O', 'and-O', 'then-O', '2-O', 'tablets-O', 'for-O', '8-O', 'weeks-O', '.-O']
['Patients-O', 'also-O', 'received-O', 'dietary-O', 'counseling-O', ',-O', 'educational-O', 'materials-O', ',-O', 'and-O', 'reminders-O', 'to-O', 'call-O', 'a-O', 'toll-O', 'free-O', 'number-O', 'that-O', 'provided-O', 'further-O', 'education-O', 'about-O', 'dyslipidemia-B-Disease', 'and-O', 'niacin-B-Chemical', 'extended-release/lovastatin-B-Chemical', '.-O']
['Primary-O', 'end-O', 'points-O', 'were-O', 'study-O', 'compliance-O', ',-O', 'increases-O', 'in-O', 'liver-O', 'transaminases-O', 'to-O', '>-O', '3-O', 'times-O', 'the-O', 'upper-O', 'limit-O', 'of-O', 'normal-O', ',-O', 'and-O', 'clinical-O', 'myopathy-B-Disease', '.-O']
['Final-O', 'study-O', 'status-O', 'was-O', 'available-O', 'for-O', '4-O', ',', '217-O', 'patients-O', '(-O', '94-O', ').-O', 'Compliance-O', 'to-O', 'niacin-B-Chemical', '/', 'lovastatin-B-Chemical', 'was-O', '77-O', ',', 'with-O', '3-O', ',', '245-O', 'patients-O', 'completing-O', 'the-O', 'study-O', '.-O']
['Patients-O', 'in-O', 'the-O', 'southeast-O', 'and-O', 'those-O', 'enrolled-O', 'by-O', 'endocrinologists-O', 'had-O', 'the-O', 'lowest-O', 'compliance-O', 'and-O', 'highest-O', 'adverse-O', 'event-O', 'rates-O', '.-O']
['Flushing-B-Disease', 'was-O', 'the-O', 'most-O', 'common-O', 'adverse-O', 'event-O', ',-O', 'reported-O', 'by-O', '18-O', '%-O', 'of-O', 'patients-O', 'and-O', 'leading-O', 'to-O', 'discontinuation-O', 'by-O', '6-O', '.-O', 'Incidence-O', 'of-O', 'increased-O', 'aspartate-B-Chemical', 'aminotransferase-O', 'and-O', '/-O', 'or-O', 'alanine-B-Chemical', 'aminotransferase-O', '>-O', '3-O', 'times-O', 'the-O', 'upper-O', 'limit-O', 'of-O', 'normal-O', 'was-O', '<-O', '0-O', '.-O']
['3-O', '.-O', 'An-O', 'increase-O', 'of-O', 'creatine-B-Chemical', 'phosphokinase-O', 'to-O', '>-O', '5-O', 'times-O', 'the-O', 'upper-O', 'limit-O', 'of-O', 'normal-O', 'occurred-O', 'in-O', '0-O', '.-O']
['24-O', '%-O', 'of-O', 'patients-O', ',-O', 'and-O', 'no-O', 'cases-O', 'of-O', 'drug-O', ',-O', 'induced-O', 'myopathy-B-Disease', 'were-O', 'observed-O', '.-O']
['Niacin-B-Chemical', 'extended-release/O', 'lovastatin-B-Chemical']
['Protective-O', 'effect-O', 'of-O', 'Terminalia-B-Chemical', 'chebula-I-Chemical', 'against-O', 'experimental-O', 'myocardial-B-Disease', 'injury-I-Disease', 'induced-O', 'by-O', 'isoproterenol-B-Chemical', '.-O']
['Cardioprotective-O', 'effect-O', 'of-O', 'ethanolic-O', 'extract-B-Chemical', 'of-I-Chemical', 'Terminalia-I-Chemical', 'chebula-I-Chemical', 'fruits-I-Chemical', '(-O', '500-O', 'mg-O', '/-O', 'kg-O', 'body-O', 'wt-O', ')-O', 'was-O', 'examined-O', 'in-O', 'isoproterenol-B-Chemical', '(-O', '200-O', 'mg-O', '/-O', 'kg-O', 'body-O', 'wt-O', ')-O', 'induced-O', 'myocardial-B-Disease', 'damage-O', 'in-O', 'rats-O', '.-O']
['In-O', 'isoproterenol-B-Chemical', 'administered-O', 'rats-O', ',-O', 'the-O', 'level-O', 'of-O', 'lipid-O', 'peroxides-O', 'increased-O', 'significantly-O', 'in-O', 'the-O', 'serum-O', 'and-O', 'heart-O', '.-O']
['A-O', 'significant-O', 'decrease-O', 'was-O', 'observed-O', 'in-O', 'the-O', 'activity-O', 'of-O', 'the-O', 'myocardial-O', 'marker-O', 'enzymes-O', 'with-O', 'a-O', 'concomitant-O', 'increase-O', 'in-O', 'their-O', 'activity-O', 'in-O', 'serum-O', '.-O']
['Histopathological-O', 'examination-O', 'was-O', 'carried-O', 'out-O', 'to-O', 'confirm-O', 'the-O', 'myocardial-B-Disease', 'necrosis-I-Disease', '.-O']
['T.-O', 'chebula-B-Chemical', 'extract-I-Chemical', 'pretreatment-O', 'was-O', 'found-O', 'to-O', 'ameliorate-O', 'the-O', 'effect-O', 'of-O', 'isoproterenol-B-Chemical', 'on-O', 'lipid-O', 'peroxide-O']
['A-O', 'case-O', 'of-O', 'postoperative-B-Disease', 'anxiety-I-Disease', 'due-O', 'to-O', 'low-O', 'dose-O', 'droperidol-B-Chemical', 'used-O', 'with-O', 'patient-O', ',-O', 'controlled-O', 'analgesia-O', '.-O']
['A-O', 'multiparous-O', 'woman-O', 'in-O', 'good-O', 'psychological-O', 'health-O', 'underwent-O', 'urgent-O', 'caesarean-O', 'section-O', 'in-O', 'labour-O', '.-O']
['Postoperatively-O', ',-O', 'she-O', 'was-O', 'given-O', 'a-O', 'patient-O', ',-O', 'controlled-O', 'analgesia-O', 'device-O', 'delivering-O', 'boluses-O', 'of-O', 'diamorphine-B-Chemical', '0-O', '.-O']
['5-O', 'mg-O', 'and-O', 'droperidol-B-Chemical', '0-O', '.-O']
['025-O', 'mg-O', '.-O']
['Whilst-O', 'using-O', 'the-O', 'device-O', 'she-O', 'gradually-O', 'became-O', 'anxious-B-Disease', ',', 'the-O', 'feeling-O', 'worsening-O', 'after-O', 'each-O', 'bolus-O', '.-O']
['The-O', 'diagnosis-O', 'of-O', 'droperidol-B-Chemical', ',-O', 'induced-O', 'psychological-B-Disease', 'disturbance-I-Disease', 'was-O', 'not-O', 'made-O', 'straight-O', 'away-O', 'although-O', 'on-O', 'subsequent-O', 'close-O', 'questioning-O', 'the-O', 'patient-O', 'gave-O', 'a-O', 'very-O', 'clear-O', 'history-O', '.-O']
['After-O', 'she-O', 'had-O', 'received-O', 'a-O', 'total-O', 'of-O', 'only-O', '0-O', '.-O']
['9-O', 'mg-O', 'droperidol-B-Chemical', ',-O', 'a-O', 'syringe-O', 'containing-O', 'diamorphine-B-Chemical']
['Accurate-O', 'patient-O', 'history-O', 'contributes-O', 'to-O', 'differentiating-O', 'diabetes-B-Disease', 'insipidus-I-Disease', ':-O', 'a-O', 'case-O', 'study-O', '.-O']
['This-O', 'case-O', 'study-O', 'highlights-O', 'the-O', 'important-O', 'contribution-O', 'of-O', 'nursing-O', 'in-O', 'obtaining-O', 'an-O', 'accurate-O', 'health-O', 'history-O', '.-O']
['The-O', 'case-O', 'discussed-O', 'herein-O', 'initially-O', 'appeared-O', 'to-O', 'be-O', 'neurogenic-B-Disease', 'diabetes-B-Disease', 'insipidus-I-Disease', '(-O', 'DI-O', ')-O', 'secondary-O', 'to-O', 'a-O', 'traumatic-O', 'brain-O', 'injury-O', '.-O']
['The-O', 'nursing-O', 'staff-O', ',-O', 'by-O', 'reviewing-O', 'the-O', 'patient-O', 'x-O', 's-O', 'health-O', 'history-O', 'with-O', 'his-O', 'family-O', ',-O', 'discovered-O', 'a-O', 'history-O', 'of-O', 'polydipsia-B-Disease', 'and-O', 'long-O', ',-O', 'standing-O', 'lithium-B-Chemical', 'use-O', '.-O']
['Lithium-B-Chemical', 'is-O', 'implicated-O', 'in-O', 'drug-O', ',-O', 'induced-O', 'nephrogenic-O', 'DI-O', ',-O', 'and-O', 'because-O', 'the-O', 'patient-O', 'had-O', 'not-O', 'received-O', 'lithium-B-Chemical', 'since-O', 'being-O', 'admitted-O', 'to-O', 'the-O', 'hospital-O', ',-O', 'his-O', 'treatment-O', 'changed-O', 'to-O', 'focus-O', 'on-O', 'nephrogenic-O', 'DI-O', '.-O']
['By-O', 'combining-O', 'information-O', 'from-O', 'the-O', 'patient-O', 'history-O', ',-O', 'the-O', 'physical-O', 'examination-O', ',-O', 'and-O', 'radiologic-O', 'and-O', 'laboratory-O', 'studies-O', ',-O', 'the-O', 'critical-O', 'care-O', 'team-O', 'demonstrated-O', 'that-O', 'the-O', 'patient-O', 'had-O', 'been-O', 'self-O', 'treating-O', 'his-O', 'lithium-B-Chemical', ',-O', 'induced-O', 'nephrogenic-O', 'DI-B-Disease', 'and-O', 'developed-O', 'neurogenic-O', 'DI-B-Disease', 'secondary-O', 'to-O', 'brain-O', 'trauma-O', '.-O']
['Thus-O', 'successful-O', 'treatment-O', 'required-O', 'that-O', 'nephrogenic-B-Disease', 'and-O', 'neurogenic-B-Disease', 'DI-B-Disease']
['Factors-O', 'contributing-O', 'to-O', 'ribavirin-B-Chemical', ',-O', 'induced-O', 'anemia-B-Disease', '.-O']
['BACKGROUND-O', 'AND-O', 'AIM-O', ':-O', 'Interferon-B-Chemical', 'and-O', 'ribavirin-B-Chemical', 'combination-O', 'therapy-O', 'for-O', 'chronic-B-Disease', 'hepatitis-I-Disease', 'C-I-Disease', 'produces-O', 'hemolytic-B-Disease', 'anemia-I-Disease', '.-O']
['This-O', 'study-O', 'was-O', 'conducted-O', 'to-O', 'identify-O', 'the-O', 'factors-O', 'contributing-O', 'to-O', 'ribavirin-B-Chemical', ',-O', 'induced-O', 'anemia-B-Disease', '.-O']
['METHODS-O', ':-O', 'Eighty-O', ',-O', 'eight-O', 'patients-O', 'with-O', 'chronic-B-Disease', 'hepatitis-I-Disease', 'C-I-Disease', 'who-O', 'received-O', 'interferon-alpha-2b-B-Chemical', 'at-O', 'a-O', 'dose-O', 'of-O', '6-O', 'MU-O', 'administered-O', 'intramuscularly-O', 'for-O', '24-O', 'weeks-O', 'in-O', 'combination-O', 'with-O', 'ribavirin-B-Chemical', 'administered-O', 'orally-O', 'at-O', 'a-O', 'dose-O', 'of-O', '600-O', 'mg-O', 'or-O', '800-O', 'mg-O', 'participated-O', 'in-O', 'the-O', 'study-O', '.-O']
['A-O', 'hemoglobin-O', 'concentration-O', 'of-O', '<-O', '10-O', 'g-O', '/-O', 'dL-O', 'was-O', 'defined-O', 'as-O', 'ribavirin-B-Chemical', ',-O', 'induced-O', 'anemia-B-Disease', '.-O']
['RESULTS-O', ':-O', 'Ribavirin-B-Chemical', ',-O', 'induced-O', 'anemia-B-Disease', 'occurred-O', 'in-O', '18-O', '(-O', '20-O', '.-O']
['5-O', ')-O', 'patients-O', 'during-O', 'treatment-O', '.-O']
['A-O', '2-O', 'g-O', '/-O', 'dL-O', 'decrease-O', 'in-O', 'hemoglobin-O', 'concentrations-O', 'in-O', 'patients-O', 'with-O', 'anemia-B-Disease', 'was-O', 'observed-O', 'at-O', 'week-O', '2-O', 'after-O', 'the-O', 'start-O', 'of-O', 'treatment-O', '.-O']
['The-O', 'hemoglobin-B-Chemical', 'concentration-O', 'in-O', 'patients-O', 'with-O', '>-O', 'or-O', '='-O', '2-O', 'g-O', '/-O', 'dL-O', 'decrease-O', 'at-O', 'week-O', '2-O', 'was-O', 'observed-O', 'to-O', 'be-O', 'significantly-O', 'lower-O', 'even-O', 'after-O', 'week-O', '2-O', 'than-O', 'in-O', 'patients-O', 'with-O', '<-O', '2-O', 'g-O', '/-O', 'dL-O', 'decrease-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'A-O', 'significant-O', 'relationship-O', 'was-O', 'observed-O', 'between-O', 'the-O', 'rate-O', 'of-O', 'reduction-O', 'of-O', 'hemoglobin-O', 'concentrations-O', 'at-O', 'week-O', '2-O', 'and-O', 'the-O', 'severity-O', 'of-O', 'anemia-B-Disease', '(-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ').-O', 'Such-O', 'factors-O', 'as-O', 'sex-O', '(-O', 'female-O', ')-O', ',-O', 'age-O', '(-O', '>-O', 'or-O', '='-O', '60-O', 'years-O', 'old-O', ')-O', ',-O', 'and-O', 'the-O', 'ribavirin-B-Chemical', 'dose-O', 'by-O', 'body-O', 'weight-O', '(-O', '12-O', 'mg-O', '/-O', 'kg-O', 'or-O', 'more-O', ')-O', 'were-O', 'significant-O', 'by-O', 'univariate-O', 'analysis-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Careful-O', 'administration-O', 'is-O', 'necessary-O', 'in-O', 'patients-O', '>-O', 'or-O', '=-O', '60-O', 'years-O', 'old-O', ',-O', 'in-O', 'female-O', 'patients-O', ',-O', 'and-O', 'in-O', 'patients-O', 'receiving-O', 'a-O', 'ribavirin-B-Chemical']
['Oxidative-O', 'damage-O', 'precedes-O', 'nitrative-O', 'damage-O', 'in-O', 'adriamycin-B-Chemical', ',-O', 'induced-O', 'cardiac-B-Disease', 'mitochondrial-O', 'injury-O', '.-O']
['The-O', 'purpose-O', 'of-O', 'the-O', 'present-O', 'study-O', 'was-O', 'to-O', 'determine-O', 'if-O', 'elevated-O', 'reactive-O', 'oxygen-B-Chemical', '(-O', 'ROS-O', ')/-O', 'nitrogen-O', 'species-O', '(-O', 'RNS-O', ')-O', 'reported-O', 'to-O', 'be-O', 'present-O', 'in-O', 'adriamycin-B-Chemical', '(-O', 'ADR-B-Chemical', ')-O', 'induced-O', 'cardiotoxicity-B-Disease', 'actually-O', 'resulted-O', 'in-O', 'cardiomyocyte-O', 'oxidative-O', '/-O', 'nitrative-O', 'damage-O', ',-O', 'and-O', 'to-O', 'quantitatively-O', 'determine-O', 'the-O', 'time-O', 'course-O', 'and-O', 'subcellular-O', 'localization-O', 'of-O', 'these-O', 'postulated-O', 'damage-O', 'products-O', 'using-O', 'an-O', 'in-O', 'vivo-O', 'approach-O', '.-O']
['B6C3-O', 'mice-O', 'were-O', 'treated-O', 'with-O', 'a-O', 'single-O', 'dose-O', 'of-O', '20-O', 'mg-O', '/-O', 'kg-O', 'ADR-B-Chemical', '.-O']
['Ultrastructural-O', 'damage-O', 'and-O', 'levels-O', 'of-O', '4-hydroxy-2-nonenal-B-Chemical', '(-O', '4HNE-B-Chemical', ')-O', 'protein-O', 'adducts-O', 'and-O', '3-nitrotyrosine-B-Chemical', '(-O', '3NT-B-Chemical', ')-O', 'were-O', 'analyzed-O', '.-O']
['Quantitative-O', 'ultrastructural-O', 'damage-O', 'using-O', 'computerized-O', 'image-O', 'techniques-O', 'showed-O', 'cardiomyocyte-O', 'injury-B-Disease', 'as-O', 'early-O', 'as-O', '3-O', 'hours-O', ',-O', 'with-O', 'mitochondria-O', 'being-O', 'the-O', 'most-O', 'extensively-O', 'and-O', 'progressively-O', 'injured-O', 'subcellular-O', 'organelle-O', '.-O']
['Analysis-O', 'of-O', '4HNE-B-Chemical', 'protein-O', 'adducts-O', 'by-O', 'immunogold-O', 'electron-O', 'microscopy-O', 'showed-O', 'appearance-O', 'of-O', '4HNE-B-Chemical', 'protein-O', 'adducts-O', 'in-O', 'mitochondria-O', 'as-O', 'early-O', 'as-O', '3-O', 'hours-O', ',-O', 'with-O', 'a-O', 'peak-O', 'at-O', '6-O', 'hours-O', 'and-O', 'subsequent-O', 'decline-O', 'at-O', '24-O', 'hours-O', '.-O']
['3NT-O', 'levels-O', 'were-O', 'significantly-O', 'increased-O', 'in-O', 'all-O', 'subcellular-O', 'compartments-O', 'at-O', '6-O', 'hours-O', 'and-O', 'subsequently-O', 'declined-O', 'at-O', '24-O', 'hours-O', '.-O']
['Our-O', 'data-O', 'showed-O', 'ADR-B-Chemical', 'induced-O', '4HNE-B-Chemical', ',-O', 'protein-O', 'adducts-O', 'in-O', 'mitochondria-O', 'at-O', 'the-O', 'same-O', 'time-O', 'point-O', 'as-O', 'when-O', 'mitochondrial-O', 'injury-B-Disease', 'initially-O', 'appeared-O', '.-O']
['These-O', 'results-O', 'document-O', 'for-O', 'the-O', 'first-O', 'time-O', 'in-O', 'vivo-O', 'that-O', 'mitochondrial-O', 'oxidative-O', 'damage-O', 'precedes-O', 'nitrative-O', 'damage-O', '.-O']
['The-O', 'progressive-O', 'nature-O', 'of-O', 'mitochondrial-B-Disease', 'injury-I-Disease']
['Sotalol-B-Chemical', ',-O', 'induced-O', 'coronary-O', 'spasm-B-Disease', 'in-O', 'a-O', 'patient-O', 'with-O', 'dilated-B-Disease', 'cardiomyopathy-I-Disease', 'associated-O', 'with-O', 'sustained-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', '.-O']
['A-O', '54-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'with-O', 'severe-O', 'left-O', 'ventricular-O', 'dysfunction-I-Disease', 'due-O', 'to-O', 'dilated-B-Disease', 'cardiomyopathy-I-Disease', 'was-O', 'referred-O', 'to-O', 'our-O', 'hospital-O', 'for-O', 'symptomatic-O', 'incessant-O', 'sustained-O', 'ventricular-O', 'tachycardia-I-Disease', '(-O', 'VT-O', ').-O', 'After-O', 'the-O', 'administration-O', 'of-O', 'nifekalant-B-Chemical', 'hydrochloride-I-Chemical', ',-O', 'sustained-O', 'VT-O', 'was-O', 'terminated-O', '.-O']
['An-O', 'alternate-O', 'class-O', 'III-O', 'agent-O', ',-O', 'sotalol-B-Chemical', ',-O', 'was-O', 'also-O', 'effective-O', 'for-O', 'the-O', 'prevention-O', 'of-O', 'VT-B-Disease', '.-O']
['However-O', ',-O', 'one-O', 'month-O', 'after-O', 'switching-O', 'over-O', 'nifekalant-B-Chemical', 'to-O', 'sotalol-B-Chemical', ',-O', 'a-O', 'short-O', 'duration-O', 'of-O', 'ST-O', 'elevation-O', 'was-O', 'documented-O', 'in-O', 'ECG-O', 'monitoring-O', 'at-O', 'almost-O', 'the-O', 'same-O', 'time-O', 'for-O', 'three-O', 'consecutive-O', 'days-O', '.-O']
['ST-O', 'elevation-O', 'with-O', 'chest-B-Disease', 'discomfort-O', 'disappeared-O', 'since-O', 'he-O', 'began-O', 'taking-O', 'long-O', 'acting-O', 'diltiazem-B-Chemical', '.-O']
['Coronary-B-Disease', 'vasospasm-I-Disease', 'may-O', 'be-O', 'induced-O', 'by-O', 'the-O', 'non-O', ',-O', 'selective-O', 'beta-O', ',-O', 'blocking-O', 'properties-O', 'of-O', 'sotalol-B-Chemical']
['Effects-O', 'of-O', 'the-O', 'antidepressant-O', 'trazodone-B-Chemical', ',-O', 'a-O', '5-HT-B-Chemical', '2A-O', '/', '2C-O', 'receptor-O', 'antagonist-O', ',-O', 'on-O', 'dopamine-B-Chemical', ',-O', 'dependent-O', 'behaviors-O', 'in-O', 'rats-O', '.-O']
['RATIONALE-O', ':-O', '5-Hydroxytryptamine-B-Chemical', ',-O', 'via-O', 'stimulation-O', 'of-O', '5-HT-B-Chemical', '2C-O', 'receptors-O', ',-O', 'exerts-O', 'a-O', 'tonic-O', 'inhibitory-O', 'influence-O', 'on-O', 'dopaminergic-O', 'neurotransmission-O', ',-O', 'whereas-O', 'activation-O', 'of-O', '5-HT-B-Chemical', '2A-O', 'receptors-O', 'enhances-O', 'stimulated-O', 'DAergic-O', 'neurotransmission-O', '.-O']
['The-O', 'antidepressant-B-Chemical', 'trazodone-B-Chemical', 'is-O', 'a-O', '5-HT-B-Chemical', '2A-O', ',-O', '2C-O', 'receptor-O', 'antagonist-O', '.-O']
['OBJECTIVES-O', ':-O', 'To-O', 'evaluate-O', 'the-O', 'effect-O', 'of-O', 'trazodone-B-Chemical', 'treatment-O', 'on-O', 'behaviors-O', 'dependent-O', 'on-O', 'the-O', 'functional-O', 'status-O', 'of-O', 'the-O', 'nigrostriatal-O', 'DAergic-O', 'system-O', '.-O']
['METHODS-O', ':-O', 'The-O', 'effect-O', 'of-O', 'pretreatment-O', 'with-O', 'trazodone-B-Chemical', 'on-O', 'dexamphetamine-B-Chemical', ',-O', 'and-O', 'apomorphine-B-Chemical', ',-O', 'induced-O', 'oral-O', 'stereotypies-O', ',-O', 'on-O', 'catalepsy-B-Disease', 'induced-O', 'by-O', 'haloperidol-B-Chemical', 'and-O', 'apomorphine-B-Chemical', '(-O', '0-O', '.-O']
['05-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', '),-O', 'on-O', 'ergometrine-B-Chemical', ',-O', 'induced-O', 'wet-O', 'dog-O', 'shake-O', '(-O', 'WDS-O', ')-O', 'behavior-O', 'and-O', 'fluoxetine-B-Chemical', ',-O', 'induced-O', 'penile-B-Disease', 'erections-I-Disease', 'was-O', 'studied-O', 'in-O', 'rats-O', '.-O']
['We-O', 'also-O', 'investigated-O', 'whether-O', 'trazodone-B-Chemical', 'induces-O', 'catalepsy-B-Disease', 'in-O', 'rats-O', '.-O']
['RESULTS-O', ':-O', 'Trazodone-B-Chemical', 'at-O', '2-O', '.-O']
['5-O', ',-O', '20-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', '.-O']
['did-O', 'not-O', 'induce-O', 'catalepsy-B-Disease', ',-O', 'and-O', 'did-O', 'not-O', 'antagonize-O', 'apomorphine-B-Chemical', '(-O', '1-O', '.-O']
['5-O', 'and-O', '3-O', 'mg-O', '/-O', 'kg-O', ')-O', 'stereotypy-B-Disease', 'and-O', 'apomorphine-B-Chemical', '(-O', '0-O', '.-O']
['05-O', 'mg-O', '/-O', 'kg-O', ')-O', 'induced-O', 'catalepsy-B-Disease', '.-O']
['However-O', ',-O', 'pretreatment-O', 'with-O', '5-O', ',-O', '10-O', 'and-O', '20-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', '.-O']
['trazodone-B-Chemical', 'enhanced-O', 'dexamphetamine-B-Chemical', 'stereotypy-O', ',-O', 'and-O', 'antagonized-O', 'haloperidol-B-Chemical', 'catalepsy-B-Disease', ',-O', 'ergometrine-B-Chemical', ',-O', 'induced-O', 'WDS-B-Disease', 'behavior-O', 'and-O', 'fluoxetine-B-Chemical', ',-O', 'induced-O', 'penile-O', 'erections-B-Disease', '.-O']
['Trazodone-B-Chemical', 'at-O', '30-O', ',-O', '40-O', 'and-O', '50-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', '.-O']
['induced-O', 'catalepsy-B-Disease', 'and-O', 'antagonized-O', 'apomorphine-B-Chemical', 'and-O', 'dexamphetamine-B-Chemical', 'stereotypies-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Our-O', 'results-O', 'indicate-O', 'that-O', 'trazodone-B-Chemical', 'at-O', '2-O', '.-O']
['5-O', ',-O', '20-O', 'mg-O', '/-O', 'kg-O', 'does-O', 'not-O', 'block-O', 'pre-O', ',-O', 'and-O', 'postsynaptic-O', 'striatal-O', 'D2-O', 'DA-O', 'receptors-O', ',-O', 'while-O', 'at-O', '30-O', ',-O', '40-O', 'and-O', '50-O', 'mg-O', '/-O', 'kg-O', 'it-O', 'blocks-O', 'postsynaptic-O', 'striatal-O', 'D2-O', 'DA-O', 'receptors-O', '.-O']
['Furthermore-O', ',-O', 'at-O', '5-O', ',-O', '10-O', 'and-O', '20-O', 'mg-O', '/-O', 'kg-O', ',-O', 'trazodone-B-Chemical', 'blocks-O', '5-HT-B-Chemical', '2A-O', 'and-O', '5-HT-B-Chemical', '2C-O', 'receptors-O', '.-O']
['We-O', 'suggest-O', 'that-O', 'trazodone-B-Chemical', '(-O', '5-O', ',-O', '10-O', 'and-O', '20-O', 'mg-O', '/-O', 'kg-O', ')-O', 'by-O', 'blocking-O', 'the-O', '5-HT-B-Chemical', '2C-O', 'receptors-O', ',-O', 'releases-O', 'the-O', 'nigrostriatal-O', 'DAergic-O', 'neurons-O', 'from-O', 'tonic-O', 'inhibition-O', 'caused-O', 'by-O', '5-HT-B-Chemical', ',-O', 'and-O', 'thereby-O', 'potentiates-O', 'dexamphetamine-B-Chemical', 'stereotypy-O', 'and-O', 'antagonizes-O', 'haloperidol-B-Chemical', 'catalepsy-B-Disease']
['Swallowing-O', 'abnormalities-O', 'and-O', 'dyskinesia-B-Disease', 'in-O', 'Parkinson-B-Disease', 'disease-I-Disease', '.-O']
['Gastrointestinal-B-Disease', 'abnormalities-I-Disease', 'in-O', 'Parkinson-B-Disease', 'disease-I-Disease', '(-O', 'PD-B-Disease', ')-O', 'have-O', 'been-O', 'known-O', 'for-O', 'almost-O', 'two-O', 'centuries-O', ',-O', 'but-O', 'many-O', 'aspects-O', 'concerning-O', 'their-O', 'pathophysiology-O', 'have-O', 'not-O', 'been-O', 'completely-O', 'clarified-O', '.-O']
['The-O', 'aim-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'characterize-O', 'the-O', 'oropharyngeal-O', 'dynamics-O', 'in-O', 'PD-B-Disease', 'patients-O', 'with-O', 'and-O', 'without-O', 'levodopa-B-Chemical', ',-O', 'induced-O', 'dyskinesia-B-Disease', '.-O']
['Fifteen-O', 'dyskinetic-B-Disease', ',-O', '12-O', 'nondyskinetic-O', 'patients-O', ',-O', 'and-O', 'a-O', 'control-O', 'group-O', 'were-O', 'included-O', '.-O']
['Patients-O', 'were-O', 'asked-O', 'about-O', 'dysphagia-B-Disease', 'and-O', 'evaluated-O', 'with-O', 'the-O', 'Unified-O', 'Parkinson-O', 'Disease-O', 'Rating-O', 'Scale-O', 'Parts-O', 'II-O', 'and-O', 'III-O', 'and-O', 'the-O', 'Hoehn-O', 'and-O', 'Yahr-O', 'scale-O', '.-O']
['Deglutition-O', 'was-O', 'assessed-O', 'using-O', 'modified-O', 'barium-B-Chemical', 'swallow-O', 'with-O', 'videofluoroscopy-O', '.-O']
['Nondyskinetic-O', 'patients-O', ',-O', 'but-O', 'not-O', 'the-O', 'dyskinetic-O', 'ones-O', ',-O', 'showed-O', 'less-O', 'oropharyngeal-O', 'swallowing-O', 'efficiency-O', '(-O', 'OPSE-O', ')-O', 'for-O', 'liquid-O', 'food-O', 'than-O', 'controls-O', '(-O', 'Dunnett-O', ',-O', 'P-O', '=', '0-O', '.-O']
['02-O', ').-O', 'Dyskinetic-B-Disease', 'patients-O', 'tended-O', 'to-O', 'have-O', 'a-O', 'greater-O', 'OPSE-O', 'than-O', 'nondyskinetic-O', '(-O', 'Dunnett-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['06-O', ').-O', 'Patients-O', 'who-O', 'were-O', 'using-O', 'a-O', 'higher-O', 'dose-O', 'of-O', 'levodopa-B-Chemical', 'had-O', 'a-O', 'greater-O', 'OPSE-O', 'and-O', 'a-O', 'trend-O', 'toward-O', 'a-O', 'smaller-O', 'oral-O', 'transit-O', 'time-O', '(-O', 'Pearson-O', 'x-O', 's-O', 'correlation-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['01-O', 'and-O', '0-O', '.-O']
['08-O', ',-O', 'respectively-O', ')-O', '.', 'Neither-O', 'the-O', 'report-O', 'of-O', 'dysphagia-B-Disease', 'nor-O', 'any-O', 'of-O', 'the-O', 'PD-B-Disease', 'severity-O', 'parameters-O', 'correlated-O', 'to-O', 'the-O', 'videofluoroscopic-O', 'variables-O', '.-O']
['In-O', 'the-O', 'current-O', 'study-O', ',-O', 'dyskinetic-B-Disease', 'patients-O', 'performed-O', 'better-O', 'in-O', 'swallowing-O', 'function-O', ',-O', 'which-O', 'could-O', 'be-O', 'explained-O', 'on-O', 'the-O', 'basis-O', 'of-O', 'a-O', 'greater-O', 'levodopa-B-Chemical', 'dose-O', '.-O']
['Our-O', 'results-O', 'suggest-O', 'a-O', 'role-O', 'for-O', 'levodopa-B-Chemical', 'in-O', 'the-O', 'oral-O', 'phase-O', 'of-O', 'deglutition-O', 'and-O', 'confirm-O', 'that-O', 'dysphagia-B-Disease', 'is-O', 'not-O', 'a-O', 'good-O', 'predictor-O', 'of-O', 'deglutition-O', 'alterations-O', 'in-O', 'PD-B-Disease']
['Inhibition-O', 'of-O', 'nuclear-O', 'factor-O', ',-O', 'kappaB-O', 'activation-O', 'attenuates-O', 'tubulointerstitial-B-Disease', 'nephritis-I-Disease', 'induced-O', 'by-O', 'gentamicin-B-Chemical', '.-O']
['BACKGROUND-O', ':-O', 'Animals-O', 'treated-O', 'with-O', 'gentamicin-B-Chemical', 'can-O', 'show-O', 'residual-O', 'areas-O', 'of-O', 'interstitial-B-Disease', 'fibrosis-I-Disease', 'in-O', 'the-O', 'renal-O', 'cortex-O', '.-O']
['This-O', 'study-O', 'investigated-O', 'the-O', 'expression-O', 'of-O', 'nuclear-O', 'factor-O', ',-O', 'kappaB-O', '(-O', 'NF-O', '-O', 'kappaB-O', ')-O', 'mitogen-O', ',-O', 'activated-O', 'protein-O', '(-O', 'MAP-O', ')-O', 'kinases-O', 'and-O', 'macrophages-O', 'in-O', 'the-O', 'renal-O', 'cortex-O', 'and-O', 'structural-O', 'and-O', 'functional-O', 'renal-O', 'changes-O', 'of-O', 'rats-O', 'treated-O', 'with-O', 'gentamicin-B-Chemical', 'or-O', 'gentamicin-B-Chemical', '+-O', 'pyrrolidine-B-Chemical', 'dithiocarbamate-O', '(-O', 'PDTC-B-Chemical', ')-O', 'an-O', 'NF-O', '-O', 'kappaB-O', 'inhibitor-O', '.-O']
['METHODS-O', ':-O', '38-O', 'female-O', 'Wistar-O', 'rats-O', 'were-O', 'injected-O', 'with-O', 'gentamicin-B-Chemical', ',-O', '40-O', 'mg-O', '/-O', 'kg-O', ',-O', 'twice-O', 'a-O', 'day-O', 'for-O', '9-O', 'days-O', ',-O', '38-O', 'with-O', 'gentamicin-B-Chemical', '+-O', 'PDTC-B-Chemical', ',-O', 'and-O', '28-O', 'with-O', '0-O', '.-O']
['15-O', 'M-O', 'NaCl-B-Chemical', 'solution-O', '.-O']
['The-O', 'animals-O', 'were-O', 'killed-O', '5-O', 'and-O', '30-O', 'days-O', 'after-O', 'these-O', 'injections-O', 'and-O', 'the-O', 'kidneys-O', 'were-O', 'removed-O', 'for-O', 'histological-O', 'and-O', 'immunohistochemical-O', 'studies-O', '.-O']
['The-O', 'results-O', 'of-O', 'the-O', 'immunohistochemical-O', 'studies-O', 'were-O', 'scored-O', 'according-O', 'to-O', 'the-O', 'extent-O', 'of-O', 'staining-O', '.-O']
['The-O', 'fractional-O', 'interstitial-B-Disease', 'area-O', 'was-O', 'determined-O', 'by-O', 'morphometry-O', '.-O']
['RESULTS-O', ':-O', 'Gentamicin-B-Chemical', ',-O', 'treated-O', 'rats-O', 'presented-O', 'a-O', 'transitory-O', 'increase-O', 'in-O', 'plasma-O', 'creatinine-B-Chemical', 'levels-O', '.-O']
['Increased-O', 'ED-B-Disease', ',-O', '1-O', ',-O', 'MAP-O', 'kinases-O', 'and-O', 'NF-O', ',-O', 'kappaB-O', 'staining-O', 'were-O', 'also-O', 'observed-O', 'in-O', 'the-O', 'renal-O', 'cortex-O', 'from-O', 'all-O', 'gentamicin-B-Chemical', ',-O', 'treated-O', 'rats-O', 'compared-O', 'to-O', 'control-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'The-O', 'animals-O', 'killed-O', 'on-O', 'day-O', '30-O', 'also-O', 'presented-O', 'fibrosis-B-Disease', 'in-O', 'the-O', 'renal-O', 'cortex-O', 'despite-O', 'the-O', 'recovery-O', 'of-O', 'renal-O', 'function-O', '.-O']
['Treatment-O', 'with-O', 'PDTC-B-Chemical', 'reduced-O', 'the-O', 'functional-O', 'and-O', 'structural-O', 'changes-O', 'induced-O', 'by-O', 'gentamicin-B-Chemical', '.-O']
['CONCLUSIONS-O', ':-O', 'These-O', 'data-O', 'show-O', 'that-O', 'inhibition-O', 'of-O', 'NF-O', ',-O', 'kappaB-O', 'activation-O', 'attenuates-O', 'tubulointerstitial-B-Disease', 'nephritis-I-Disease', 'induced-O', 'by-O', 'gentamicin-B-Chemical']
['Glucose-B-Chemical', 'metabolism-O', 'in-O', 'patients-O', 'with-O', 'schizophrenia-B-Disease', 'treated-O', 'with-O', 'atypical-O', 'antipsychotic-O', 'agents-O', ':-O', 'a-O', 'frequently-O', 'sampled-O', 'intravenous-O', 'glucose-B-Chemical', 'tolerance-O', 'test-O', 'and-O', 'minimal-O', 'model-O', 'analysis-O', '.-O']
['BACKGROUND-O', ':-O', 'While-O', 'the-O', 'incidence-O', 'of-O', 'new-O', 'onset-O', 'diabetes-B-Disease', 'mellitus-I-Disease', 'may-O', 'be-O', 'increasing-O', 'in-O', 'patients-O', 'with-O', 'schizophrenia-B-Disease', 'treated-O', 'with-O', 'certain-O', 'atypical-O', 'antipsychotic-O', 'agents-O', ',-O', 'it-O', 'remains-O', 'unclear-O', 'whether-O', 'atypical-O', 'agents-O', 'are-O', 'directly-O', 'affecting-O', 'glucose-B-Chemical', 'metabolism-O', 'or-O', 'simply-O', 'increasing-O', 'known-O', 'risk-O', 'factors-O', 'for-O', 'diabetes-B-Disease', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'study-O', 'the-O', '2-O', 'drugs-O', 'most-O', 'clearly-O', 'implicated-O', '(-O', 'clozapine-B-Chemical', 'and-O', 'olanzapine-B-Chemical', ')-O', 'and-O', 'risperidone-B-Chemical', 'using-O', 'a-O', 'frequently-O', 'sampled-O', 'intravenous-O', 'glucose-B-Chemical', 'tolerance-O', 'test-O', '.-O']
['DESIGN-O', ':-O', 'A-O', 'cross-O', ',-O', 'sectional-O', 'design-O', 'in-O', 'stable-O', ',-O', 'treated-O', 'patients-O', 'with-O', 'schizophrenia-B-Disease', 'evaluated-O', 'using-O', 'a-O', 'frequently-O', 'sampled-O', 'intravenous-O', 'glucose-B-Chemical', 'tolerance-O', 'test-O', 'and-O', 'the-O', 'Bergman-O', 'minimal-O', 'model-O', 'analysis-O', '.-O']
['SETTING-O', ':-O', 'Subjects-O', 'were-O', 'recruited-O', 'from-O', 'an-O', 'urban-O', 'community-O', 'mental-B-Disease', 'health-O', 'clinic-O', 'and-O', 'were-O', 'studied-O', 'at-O', 'a-O', 'general-O', 'clinical-O', 'research-O', 'center-O', '.-O']
['Patients-O', 'Fifty-O', 'subjects-O', 'signed-O', 'informed-O', 'consent-O', 'and-O', '41-O', 'underwent-O', 'the-O', 'frequently-O', 'sampled-O', 'intravenous-O', 'glucose-B-Chemical', 'tolerance-O', 'test-O', '.-O']
['Thirty-O', ',-O', 'six-O', 'nonobese-O', 'subjects-O', 'with-O', 'schizophrenia-B-Disease', 'or-O', 'schizoaffective-B-Disease', 'disorder-O', ',-O', 'matched-O', 'by-O', 'body-O', 'mass-O', 'index-O', 'and-O', 'treated-O', 'with-O', 'either-O', 'clozapine-B-Chemical', ',-O', 'olanzapine-B-Chemical', ',-O', 'or-O', 'risperidone-B-Chemical', ',-O', 'were-O', 'included-O', 'in-O', 'the-O', 'analysis-O', '.-O']
['MAIN-O', 'OUTCOME-O', 'MEASURES-O', ':-O', 'Fasting-O', 'plasma-O', 'glucose-B-Chemical', 'and-O', 'fasting-O', 'serum-O', 'insulin-B-Chemical', 'levels-O', ',-O', 'insulin-O', 'sensitivity-O', 'index-O', ',-O', 'homeostasis-O', 'model-O', 'assessment-O', 'of-O', 'insulin-O', 'resistance-O', ',-O', 'and-O', 'glucose-B-Chemical', 'effectiveness-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'mean-O', '+-O', 'SD-O', 'duration-O', 'of-O', 'treatment-O', 'with-O', 'the-O', 'identified-O', 'atypical-O', 'antipsychotic-O', 'agent-O', 'was-O', '68-O', '.-O']
['3-O', '+-O', '28-O', '.-O']
['9-O', 'months-O', '(-O', 'clozapine-B-Chemical', ')-O', '29-O', '.-O']
['5-O', '+-O', '17-O', '.-O']
['5-O', 'months-O', '(-O', 'olanzapine-B-Chemical', ')-O', 'and-O', '40-O', '.-O']
['9-O', '+-O', '33-O', '.-O']
['7-O', '(-O', 'risperidone-B-Chemical', ').-O', 'Fasting-O', 'serum-O', 'insulin-O', 'concentrations-O', 'differed-O', 'among-O', 'groups-O', '(-O', 'F-O', '(-O', '33-O', ')-O', '3-O', '.-O']
['35-O', ';-O', 'P-O', '=.-O', '047-O', ')-O', '(-O', 'clozapine-B-Chemical', '>-O', 'olanzapine-B-Chemical', '>-O', 'risperidone-B-Chemical', ')-O', 'with-O', 'significant-O', 'differences-O', 'between-O', 'clozapine-B-Chemical', 'and-O', 'risperidone-B-Chemical', '(-O', 't-O', '(-O', '33-O', ')-O', '2-O', '.-O']
['32-O', ';-O', 'P-O', '=.-O', '03-O', ')-O', 'and-O', 'olanzapine-B-Chemical', 'and-O', 'risperidone-B-Chemical', '(-O', 't-O', '(-O', '33-O', ')-O', '2-O', '.-O']
['15-O', ';-O', 'P-O', '=-O', '.-O', '04-O', ').-O', 'There-O', 'was-O', 'a-O', 'significant-O', 'difference-O', 'in-O', 'insulin-B-Chemical', 'sensitivity-O', 'index-O', 'among-O', 'groups-O', '(-O', 'F-O', '(-O', '33-O', ')-O', '10-O', '.-O']
['66-O', ';-O', 'P-O', '<.-O', '001-O', ')-O', '('-O', 'clozapine-B-Chemical', '<-O', 'olanzapine-B-Chemical', '<-O', 'risperidone-B-Chemical', ')-O', ',', 'with-O', 'subjects-O', 'who-O', 'received-O', 'clozapine-B-Chemical', 'and-O', 'olanzapine-B-Chemical', 'exhibiting-O', 'significant-O', 'insulin-O', 'resistance-O', 'compared-O', 'with-O', 'subjects-O', 'who-O', 'were-O', 'treated-O', 'with-O', 'risperidone-B-Chemical', '(-O', 'clozapine-B-Chemical', 'vs-O', 'risperidone-B-Chemical', ',-O', 't-O', '(-O', '33-O', ')-O', '4-O', '.-O']
['29-O', ';-O', 'P-O', '<.-O', '001-O', ';-O', 'olanzapine-B-Chemical', 'vs-O', 'risperidone-B-Chemical', ',-O', 't-O', '(-O', '33-O', ')-O', '3-O', '.-O']
['62-O', ';-O', 'P-O', '=.-O', '001-O', '[', 'P-O', '<.-O', '001-O', ']).-O', 'The-O', 'homeostasis-O', 'model-O', 'assessment-O', 'of-O', 'insulin-B-Chemical', 'resistance-O', 'also-O', 'differed-O', 'significantly-O', 'among-O', 'groups-O', '(-O', 'F-O', '(-O', '33-O', ')-O', '4-O', '.-O']
['92-O', ';-O', 'P-O', '=.-O', '01-O', ')-O', '(-O', 'clozapine-B-Chemical', '>-O', 'olanzapine-B-Chemical', '>-O', 'risperidone-B-Chemical', ')-O', '(-O', 'clozapine-B-Chemical', 'vs-O', 'risperidone-B-Chemical', ',-O', 't-O', '(-O', '33-O', ')-O', '2-O', '.-O']
['94-O', ';-O', 'P-O', '=.-O', '006-O', ';-O', 'olanzapine-B-Chemical', 'vs-O', 'risperidone-B-Chemical', ',-O', 't-O', '(-O', '33-O', ')-O', '2-O', '.-O']
['42-O', ';-O', 'P-O', '=-O', '.-O', '02-O', ').-O', 'There-O', 'was-O', 'a-O', 'significant-O', 'difference-O', 'among-O', 'groups-O', 'in-O', 'glucose-B-Chemical', 'effectiveness-O', '(-O', 'F-O', '(-O', '30-O', ')-O', '4-O', '.-O']
['18-O', ';-O', 'P-O', '=.-O', '02-O', ')-O', '(-O', 'clozapine-B-Chemical', '<-O', 'olanzapine-B-Chemical', '<-O', 'risperidone-B-Chemical', ')-O', 'with-O', 'significant-O', 'differences-O', 'between-O', 'clozapine-B-Chemical', 'and-O', 'risperidone-B-Chemical', '(-O', 't-O', '(-O', '30-O', ')-O', '2-O', '.-O']
['59-O', ';-O', 'P-O', '=-O', '.-O', '02-O', ')-O', 'and-O', 'olanzapine-B-Chemical', 'and-O', 'risperidone-B-Chemical', '(-O', 't-O', '(-O', '30-O', ')-O', '2-O', '.-O']
['34-O', ',-O', 'P-O', '=.-O', '03-O', ')-O', 'CONCLUSIONS-O', ':', 'Both-O', 'nonobese-O', 'clozapine-B-Chemical', ',-O', 'and-O', 'olanzapine-B-Chemical', ',-O', 'treated-O', 'groups-O', 'displayed-O', 'significant-O', 'insulin-O', 'resistance-O', 'and-O', 'impairment-O', 'of-O', 'glucose-B-Chemical', 'effectiveness-O', 'compared-O', 'with-O', 'risperidone-B-Chemical', ',-O', 'treated-O', 'subjects-O', '.-O']
['Patients-O', 'taking-O', 'clozapine-B-Chemical', 'and-O', 'olanzapine-B-Chemical', 'must-O', 'be-O', 'examined-O', 'for-O', 'insulin-B-Chemical', 'resistance-O']
['Focal-O', 'cerebral-O', 'ischemia-B-Disease', 'in-O', 'rats-O', ':-O', 'effect-O', 'of-O', 'phenylephrine-B-Chemical', ',-O', 'induced-O', 'hypertension-B-Disease', 'during-O', 'reperfusion-O', '.-O']
['After-O', '180-O', 'min-O', 'of-O', 'temporary-O', 'middle-O', 'cerebral-O', 'artery-O', 'occlusion-O', 'in-O', 'spontaneously-O', 'hypertensive-B-Disease', 'rats-O', ',-O', 'the-O', 'effect-O', 'of-O', 'phenylephrine-B-Chemical', ',-O', 'induced-O', 'hypertension-B-Disease', 'on-O', 'ischemic-B-Disease', 'brain-O', 'injury-O', 'and-O', 'blood-O', ',-O', 'brain-O', 'barrier-O', 'permeability-O', 'was-O', 'determined-O', '.-O']
['Blood-O', 'pressure-O', 'was-O', 'manipulated-O', 'by-O', 'one-O', 'of-O', 'the-O', 'following-O', 'schedules-O', 'during-O', '120-O', 'min-O', 'of-O', 'reperfusion-O', ':-O', 'Control-O', ',-O', 'normotensive-O', 'reperfusion-O', ';-O', '90-O', '/-O', 'hypertension-B-Disease', '(-O', '90-O', '/-O', 'HTN-O', ')-O', 'blood-O', 'pressure-O', 'was-O', 'increased-O', 'by-O', '35-O', 'mm-O', 'Hg-O', 'during-O', 'the-O', 'initial-O', '90-O', 'min-O', 'of-O', 'reperfusion-O', 'only-O', ';-O', '15-O', '/-O', 'hypertension-B-Disease', '(-O', '15-O', '/-O', 'HTN-O', ')-O', 'normotensive-O', 'reperfusion-O', 'for-O', '30-O', 'min-O', 'followed-O', 'by-O', '15-O', 'min-O', 'of-O', 'hypertension-B-Disease', 'and-O', '75-O', 'min-O', 'of-O', 'normotension-O', '.-O']
['Part-O', 'A-O', ',-O', 'for-O', 'eight-O', 'rats-O', 'in-O', 'each-O', 'group-O', 'brain-O', 'injury-B-Disease', 'was-O', 'evaluated-O', 'by-O', 'staining-O', 'tissue-O', 'using-O', '2,3,5-triphenyltetrazolium-B-Chemical', 'chloride-I-Chemical', 'and-O', 'edema-B-Disease', 'was-O', 'evaluated-O', 'by-O', 'microgravimetry-O', '.-O']
['Part-O', 'B-O', ',-O', 'for-O', 'eight-O', 'different-O', 'rats-O', 'in-O', 'each-O', 'group-O', 'blood-O', ',-O', 'brain-O', 'barrier-O', 'permeability-O', 'was-O', 'evaluated-O', 'by-O', 'measuring-O', 'the-O', 'amount-O', 'and-O', 'extent-O', 'of-O', 'extravasation-O', 'of-O', 'Evans-O', 'Blue-O', 'dye-O', '.-O']
['Brain-O', 'injury-I-Disease', '(-O', 'percentage-O', 'of-O', 'the-O', 'ischemic-O', 'hemisphere-O', ')-O', 'was-O', 'less-O', 'in-O', 'the-O', '15-O', '/-O', 'HTN-O', 'group-O', '(-O', '16-O', '+-O', '6-O', ',-O', 'mean-O', '+-O', 'SD-O', ')-O', 'versus-O', 'the-O', '90-O', '/-O', 'HTN-O', 'group-O', '(-O', '30-O', '+-O', '6-O', ')-O', ',-O', 'which-O', 'was-O', 'in-O', 'turn-O', 'less-O', 'than-O', 'the-O', 'control-O', 'group-O', '(-O', '42-O', '+-O', '5-O', ')-O', '.-O', 'Specific-O', 'gravity-O', 'was-O', 'greater-O', 'in-O', 'the-O', '15-O', '/-O', 'HTN-O', 'group-O', '(-O', '1-O', '.-O']
['043-O', '+-O', '0-O', '.-O']
['002-O', ')-O', 'versus-O', 'the-O', '90-O', '/-O', 'HTN-B-Disease', '(-O', '1-O', '.-O']
['036-O', '+-O', '0-O', '.-O']
['003-O', ')-O', 'and-O', 'control-O', '(-O', '1-O', '.-O']
['037-O', '+-O', '0-O', '.-O']
['003-O', ')-O', 'groups-O', '.-O']
['Evans-O', 'Blue-B-Chemical', '(-O', 'mug-O', 'g-O', ',-O', '1-O', 'of-O', 'brain-O', 'tissue-O', ')', 'was-O', 'greater-O', 'in-O', 'the-O', '90-O', '/-O', 'HTN-B-Disease', 'group-O', '(-O', '24-O', '.-O']
['4-O', '+-O', '6-O', '.-O']
['0-O', ')-O', 'versus-O', 'the-O', 'control-O', 'group-O', '(-O', '12-O', '.-O']
['3-O', '+-O', '4-O', '.-O']
['1-O', '),-O', 'which-O', 'was-O', 'in-O', 'turn-O', 'greater-O', 'than-O', 'the-O', '15-O', '/-O', 'HTN-B-Disease', 'group-O', '(-O', '7-O', '.-O']
['3-O', '+-O', '3-O', '.-O']
['2-O', ').-O', 'This-O', 'study-O', 'supports-O', 'a-O', 'hypothesis-O', 'that-O', 'during-O', 'reperfusion-O', ',-O', 'a-O', 'short-O', 'interval-O', 'of-O', 'hypertension-B-Disease', 'decreases-O', 'brain-O', 'injury-I-Disease', 'and-O', 'edema-I-Disease', ';-O', 'and-O', 'that-O', 'sustained-O', 'hypertension-B-Disease', 'increases-O', 'the-O', 'risk-O', 'of-O', 'vasogenic-O', 'edema-I-Disease']
['People-O', 'aged-O', 'over-O', '75-O', 'in-O', 'atrial-B-Disease', 'fibrillation-I-Disease', 'on-O', 'warfarin-B-Chemical', ':-O', 'the-O', 'rate-O', 'of-O', 'major-O', 'hemorrhage-O', 'and-O', 'stroke-B-Disease', 'in-O', 'more-O', 'than-O', '500-O', 'patient-O', ',-O', 'years-O', 'of-O', 'follow-O', ',-O', 'up-O', '.-O']
['OBJECTIVES-O', ':-O', 'To-O', 'determine-O', 'the-O', 'incidence-O', 'of-O', 'major-O', 'hemorrhage-B-Disease', 'and-O', 'stroke-B-Disease', 'in-O', 'people-O', 'aged-O', '76-O', 'and-O', 'older-O', 'with-O', 'atrial-B-Disease', 'fibrillation-I-Disease', 'on-O', 'adjusted-O', ',-O', 'dose-O', 'warfarin-B-Chemical', 'who-O', 'had-O', 'been-O', 'recently-O', 'been-O', 'admitted-O', 'to-O', 'hospital-O', '.-O']
['DESIGN-O', ':-O', 'A-O', 'retrospective-O', 'observational-O', 'cohort-O', 'study-O', '.-O']
['SETTING-O', ':-O', 'A-O', 'major-O', 'healthcare-O', 'network-O', 'involving-O', 'four-O', 'tertiary-O', 'hospitals-O', '.-O']
['PARTICIPANTS-O', ':-O', 'Two-O', 'hundred-O', 'thirty-O', ',-O', 'five-O', 'patients-O', 'aged-O', '76-O', 'and-O', 'older-O', 'admitted-O', 'to-O', 'a-O', 'major-O', 'healthcare-O', 'network-O', 'between-O', 'July-O', '1-O', ',-O', '2001-O', ',-O', 'and-O', 'June-O', '30-O', ',-O', '2002-O', ',-O', 'with-O', 'atrial-B-Disease', 'fibrillation-I-Disease', 'on-O', 'warfarin-B-Chemical', 'were-O', 'enrolled-O', '.-O']
['MEASUREMENTS-O', ':-O', 'Information-O', 'regarding-O', 'major-O', 'bleeding-B-Disease', 'episodes-O', ',-O', 'strokes-I-Disease', ',-O', 'and-O', 'warfarin-B-Chemical', 'use-O', 'was-O', 'obtained-O', 'from-O', 'patients-O', ',-O', 'relatives-O', ',-O', 'primary-O', 'physicians-O', ',-O', 'and-O', 'medical-O', 'records-O', '.-O']
['RESULTS-O', ':-O', 'Two-O', 'hundred-O', 'twenty-O', 'eight-O', 'patients-O', '(-O', '42-O', '%-O', 'men-O', ')-O', 'with-O', 'a-O', 'mean-O', 'age-O', 'of-O', '81-O', '.-O']
['1-O', '(-O', 'range-O', '76-O', ',-O', '94-O', ')-O', 'were-O', 'included-O', 'in-O', 'the-O', 'analysis-O', '.-O']
['Total-O', 'follow-O', ',-O', 'up-O', 'on-O', 'warfarin-B-Chemical', 'was-O', '530-O', 'years-O', '(-O', 'mean-O', '28-O', 'months-O', ').-O', 'There-O', 'were-O', '53-O', 'major-O', 'hemorrhages-B-Disease', ',-O', 'for-O', 'an-O', 'annual-O', 'rate-O', 'of-O', '10-O', '.-O']
['0-O', ',-O', 'including-O', '24-O', '(-O', '45-O', '.-O']
['3-O', ')-O', 'life-O', ',-O', 'threatening-O', 'and-O', 'five-O', '(-O', '9-O', '.-O']
['4-O', ')-O', 'fatal-O', 'bleeds-B-Disease', '.-O']
['The-O', 'annual-O', 'stroke-B-Disease', 'rate-O', 'after-O', 'initiation-O', 'of-O', 'warfarin-B-Chemical', 'was-O', '2-O', '.-O']
['6-O', '.-O', 'CONCLUSION-O', ':-O', 'The-O', 'rate-O', 'of-O', 'major-O', 'hemorrhage-B-Disease', 'was-O', 'high-O', 'in-O', 'this-O', 'old-O', ',-O', 'frail-O', 'group-O', ',-O', 'but-O', 'excluding-O', 'fatalities-O', ',-O', 'resulted-O', 'in-O', 'no-O', 'long-O', ',-O', 'term-O', 'sequelae-O', ',-O', 'and-O', 'the-O', 'stroke-B-Disease', 'rate-O', 'on-O', 'warfarin-B-Chemical', 'was-O', 'low-O', ',-O', 'demonstrating-O', 'how-O', 'effective-O', 'warfarin-B-Chemical']
['Safety-O', 'of-O', 'celecoxib-B-Chemical', 'in-O', 'patients-O', 'with-O', 'adverse-O', 'skin-O', 'reactions-O', 'to-O', 'acetaminophen-B-Chemical', '(-O', 'paracetamol-B-Chemical', ')-O', 'and-O', 'nimesulide-B-Chemical', 'associated-O', 'or-O', 'not-O', 'with-O', 'common-O', 'non-O', '-O', 'steroidal-O', 'anti-O', '-O', 'inflammatory-O', 'drugs-O', '.-O']
['BACKGROUND-O', ':-O', 'Acetaminophen-B-Chemical', '(-O', 'paracetamol-B-Chemical', '--O', 'P-O', ')-O', 'and-O', 'Nimesulide-B-Chemical', '(-O', 'N-O', ')-O', 'are-O', 'widely-O', 'used-O', 'analgesic-O', ',-O', 'antipyretic-O', '/-O', 'anti-O', ',-O', 'inflammatory-O', 'drugs-O', '.-O']
['The-O', 'rate-O', 'of-O', 'adverse-O', 'hypersensitivity-B-Disease', 'reactions-O', 'to-O', 'these-O', 'agents-O', 'is-O', 'generally-O', 'low-O', '.-O']
['On-O', 'the-O', 'contrary-O', 'non-O', ',-O', 'steroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'drugs-O', '(-O', 'NSAIDs-B-Chemical', ')-O', 'are-O', 'commonly-O', 'involved-O', 'in-O', 'such-O', 'reactions-O', '.-O']
['Celecoxib-B-Chemical', '(-O', 'CE-B-Chemical', ')-O', 'is-O', 'a-O', 'novel-O', 'drug-O', ',-O', 'with-O', 'high-O', 'selectivity-O', 'and-O', 'affinity-O', 'for-O', 'COX-O', ',-O', '2-O', 'enzyme-O', '.-O']
['OBJECTIVE-O', ':-O', 'We-O', 'evaluated-O', 'the-O', 'tolerability-O', 'of-O', 'CE-B-Chemical', 'in-O', 'a-O', 'group-O', 'of-O', 'patients-O', 'with-O', 'documented-O', 'history-O', 'of-O', 'adverse-O', 'cutaneous-O', 'reactions-O', 'to-O', 'P-B-Chemical', 'and-O', 'N-B-Chemical', 'associated-O', 'or-O', 'not-O', 'to-O', 'classic-O', 'NSAIDs-B-Chemical', '.-O']
['METHODS-O', ':-O', 'We-O', 'studied-O', '9-O', 'patients-O', 'with-O', 'hypersensitivity-B-Disease', 'to-O', 'P-B-Chemical', 'and-O', 'N-B-Chemical', 'with-O', 'or-O', 'without-O', 'associated-O', 'reactions-O', 'to-O', 'classic-O', 'NSAIDs-B-Chemical', '.-O']
['The-O', 'diagnosis-O', 'of-O', 'P-B-Chemical', 'and-O', 'N-B-Chemical', ',-O', 'induced-O', 'skin-O', 'reactions-O', 'was-O', 'based-O', 'in-O', 'vivo-O', 'challenge-O', '.-O']
['The-O', 'placebo-O', 'was-O', 'blindly-O', 'administered-O', 'at-O', 'the-O', 'beginning-O', 'of-O', 'each-O', 'challenge-O', '.-O']
['After-O', 'three-O', 'days-O', ',-O', 'a-O', 'cumulative-O', 'dosage-O', 'of-O', '200-O', 'mg-O', 'of-O', 'CE-B-Chemical', 'in-O', 'refracted-O', 'doses-O', 'were-O', 'given-O', '.-O']
['After-O', '2-O', ',-O', '3-O', 'days-O', ',-O', 'a-O', 'single-O', 'dose-O', 'of-O', '200-O', 'mg-O', 'was-O', 'administered-O', '.-O']
['All-O', 'patients-O', 'were-O', 'observed-O', 'for-O', '6-O', 'hours-O', 'after-O', 'each-O', 'challenge-O', ',-O', 'and-O', 'controlled-O', 'again-O', 'after-O', '24-O', 'hours-O', 'to-O', 'exclude-O', 'delayed-O', 'reactions-O', '.-O']
['The-O', 'challenge-O', 'was-O', 'considered-O', 'positive-O', 'if-O', 'one-O', 'or-O', 'more-O', 'of-O', 'the-O', 'following-O', 'appeared-O', ':-O', 'erythema-B-Disease', ',-O', 'rush-B-Disease', 'or-O', 'urticaria-B-Disease', ',-O', 'angioedema-B-Disease', '.-O']
['RESULTS-O', ':-O', 'No-O', 'reaction-O', 'was-O', 'observed-O', 'with-O', 'placebo-O', 'and-O', 'eight-O', 'patients-O', '(-O', '88-O', '.-O']
['8-O', ')-O', 'tolerated-O', 'CE-B-Chemical', '.-O']
['Only-O', 'one-O', 'patient-O', 'developed-O', 'a-O', 'moderate-O', 'angioedema-B-Disease', 'of-O', 'the-O', 'lips-O', '.-O']
['CONCLUSION-O', ':-O', 'Only-O', 'one-O', 'hypersensitivity-B-Disease', 'reaction-I-Disease', 'to-O', 'CE-B-Chemical', 'was-O', 'documented-O', 'among-O', '9-O', 'P-O', 'and-O', 'N-O', ',-O', 'highly-O', 'NSAIDs-B-Chemical', 'intolerant-O', 'patients-O', '.-O']
['Thus-O', ',-O', 'we-O', 'conclude-O', 'that-O', 'CE-B-Chemical', 'is-O', 'a-O', 'reasonably-O', 'safe-O', 'alternative-O', 'to-O', 'be-O', 'used-O', 'in-O', 'subjects-O', 'who-O', 'do-O', 'not-O', 'tolerate-O', 'P-B-Chemical', 'and-O', 'N-B-Chemical']
['Case-O', ',-O', 'control-O', 'study-O', 'of-O', 'regular-O', 'analgesic-O', 'and-O', 'nonsteroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'use-O', 'and-O', 'end-stage-B-Disease', 'renal-I-Disease', 'disease-I-Disease', '.-O']
['BACKGROUND-O', ':-O', 'Studies-O', 'on-O', 'the-O', 'association-O', 'between-O', 'the-O', 'long-O', ',-O', 'term-O', 'use-O', 'of-O', 'aspirin-B-Chemical', 'and-O', 'other-O', 'analgesic-O', 'and-O', 'nonsteroidal-O', '--O', 'anti-O', ',-O', 'inflammatory-O', 'drugs-O', '(-O', 'NSAIDs-O', ')-O', 'and-O', 'end-stage-B-Disease', 'renal-I-Disease', 'disease-I-Disease', '(-O', 'ESRD-B-Disease', ')-O', 'have-O', 'given-O', 'conflicting-O', 'results-O', '.-O']
['In-O', 'order-O', 'to-O', 'examine-O', 'this-O', 'association-O', ',-O', 'a-O', 'case-O', ',-O', 'control-O', 'study-O', 'with-O', 'incident-O', 'cases-O', 'of-O', 'ESRD-B-Disease', 'was-O', 'carried-O', 'out-O', '.-O']
['METHODS-O', ':-O', 'The-O', 'cases-O', 'were-O', 'all-O', 'patients-O', 'entering-O', 'the-O', 'local-O', 'dialysis-O', 'program-O', 'because-O', 'of-O', 'ESRD-B-Disease', 'in-O', 'the-O', 'study-O', 'area-O', 'between-O', 'June-O', '1-O', ',-O', '1995-O', 'and-O', 'November-O', '30-O', ',-O', '1997-O', '.-O']
['They-O', 'were-O', 'classified-O', 'according-O', 'to-O', 'the-O', 'underlying-O', 'disease-O', ',-O', 'which-O', 'had-O', 'presumably-O', 'led-O', 'them-O', 'to-O', 'ESRD-B-Disease', '.-O']
['Controls-O', 'were-O', 'patients-O', 'admitted-O', 'to-O', 'the-O', 'same-O', 'hospitals-O', 'from-O', 'where-O', 'the-O', 'cases-O', 'arose-O', ',-O', 'also-O', 'matched-O', 'by-O', 'age-O', 'and-O', 'sex-O', '.-O']
['Odds-O', 'ratios-O', 'were-O', 'calculated-O', 'using-O', 'a-O', 'conditional-O', 'logistic-O', 'model-O', ',-O', 'including-O', 'potential-O', 'confounding-O', 'factors-O', ',-O', 'both-O', 'for-O', 'the-O', 'whole-O', 'study-O', 'population-O', 'and-O', 'for-O', 'the-O', 'various-O', 'underlying-O', 'diseases-B-Disease', '.-O']
['RESULTS-O', ':-O', 'Five-O', 'hundred-O', 'and-O', 'eighty-O', ',-O', 'three-O', 'cases-O', 'and-O', '1190-O', 'controls-O', 'were-O', 'included-O', 'in-O', 'the-O', 'analysis-O', '.-O']
['Long-O', ',-O', 'term-O', 'use-O', 'of-O', 'any-O', 'analgesic-O', 'was-O', 'associated-O', 'with-O', 'an-O', 'overall-O', 'odds-O', 'ratio-O', 'of-O', '1-O', '.-O']
['22-O', '(-O', '95-O', '%-O', 'CI-O', ',-O', '0-O', '.-O']
['89-O', ',-O', '1-O', '.-O']
['66-O', ').-O', 'For-O', 'specific-O', 'groups-O', 'of-O', 'drugs-O', ',-O', 'the-O', 'risks-O', 'were-O', '1-O', '.-O']
['56-O', '(-O', '1-O', '.-O']
['05-O', ',-O', '2-O', '.-O']
['30-O', ')-O', 'for-O', 'aspirin-B-Chemical', ',-O', '1-O', '.-O']
['03-O', '(-O', '0-O', '.-O']
['60-O', ',-O', '1-O', '.-O']
['76-O', ')-O', 'for-O', 'pyrazolones-B-Chemical', ',-O', '0-O', '.-O']
['80-O', '(-O', '0-O', '.-O']
['39-O', ',-O', '1-O', '.-O']
['63-O', ')-O', 'for-O', 'paracetamol-B-Chemical', ',-O', 'and-O', '0-O', '.-O']
['94-O', '(-O', '0-O', '.-O']
['57-O', ',-O', '1-O', '.-O']
['56-O', ')-O', 'for-O', 'nonaspirin-O', 'NSAIDs-B-Chemical', '.-O']
['The-O', 'risk-O', 'of-O', 'ESRD-B-Disease', 'associated-O', 'with-O', 'aspirin-B-Chemical', 'was-O', 'related-O', 'to-O', 'the-O', 'cumulated-O', 'dose-O', 'and-O', 'duration-O', 'of-O', 'use-O', ',-O', 'and-O', 'it-O', 'was-O', 'particularly-O', 'high-O', 'among-O', 'the-O', 'subset-O', 'of-O', 'patients-O', 'with-O', 'vascular-O', 'nephropathy-B-Disease', 'as-O', 'underlying-O', 'disease-O', '[', '2-O', '.-O']
['35-O', '(-O', '1-O', '.-O']
['17-O', ',-O', '4-O', '.-O']
['72-O', ')-O', '.-O', 'CONCLUSION-O', ':-O', 'Our-O', 'data-O', 'indicate-O', 'that-O', 'long-O', ',-O', 'term-O', 'use-O', 'of-O', 'nonaspirin-O', 'analgesic-O', 'drugs-O', 'and-O', 'NSAIDs-B-Chemical', 'is-O', 'not-O', 'associated-O', 'with-O', 'an-O', 'increased-O', 'risk-O', 'of-O', 'ESRD-B-Disease', '.-O']
['However-O', ',-O', 'the-O', 'chronic-O', 'use-O', 'of-O', 'aspirin-B-Chemical', 'may-O', 'increase-O', 'the-O', 'risk-O', 'of-O', 'ESRD-B-Disease']
['Two-O', 'cases-O', 'of-O', 'amisulpride-B-Chemical', 'overdose-B-Disease', ':-O', 'a-O', 'cause-O', 'for-O', 'prolonged-O', 'QT-O', 'syndrome-I-Disease', '.-O']
['Two-O', 'cases-O', 'of-O', 'deliberate-O', 'self-O', ',-O', 'poisoning-B-Disease', 'with-O', '5-O', 'g-O', 'and-O', '3-O', '.-O']
['6-O', 'g-O', 'of-O', 'amisulpride-B-Chemical', ',-O', 'respectively-O', ',-O', 'are-O', 'reported-O', '.-O']
['In-O', 'both-O', 'cases-O', ',-O', 'QT-O', 'prolongation-B-Disease', 'and-O', 'hypocalcaemia-B-Disease', 'were-O', 'noted-O', '.-O']
['The-O', 'QT-O', 'prolongation-B-Disease', 'appeared-O', 'to-O', 'respond-O', 'to-O', 'administration-O', 'of-O', 'i-O', '.-O']
['v-O', '.-O']
['calcium-B-Chemical', 'gluconate-I-Chemical']
['Growth-O', ',-O', 'associated-O', 'protein-O', '43-O', 'expression-O', 'in-O', 'hippocampal-O', 'molecular-O', 'layer-O', 'of-O', 'chronic-B-Disease', 'epileptic-B-Disease', 'rats-O', 'treated-O', 'with-O', 'cycloheximide-B-Chemical', '.-O']
['PURPOSE-O', ':-O', 'GAP43-O', 'has-O', 'been-O', 'thought-O', 'to-O', 'be-O', 'linked-O', 'with-O', 'mossy-O', 'fiber-O', 'sprouting-O', '(-O', 'MFS-O', ')-O', 'in-O', 'various-O', 'experimental-O', 'models-O', 'of-O', 'epilepsy-B-Disease', '.-O']
['To-O', 'investigate-O', 'how-O', 'GAP43-O', 'expression-O', '(-O', 'GAP43-O', ',', 'ir-O', ')-O', 'correlates-O', 'with-O', 'MFS-O', ',-O', 'we-O', 'assessed-O', 'the-O', 'intensity-O', '(-O', 'densitometry-O', ')-O', 'and-O', 'extension-O', '(-O', 'width-O', ')-O', 'of-O', 'GAP43-O', ',', 'ir-O', 'in-O', 'the-O', 'inner-O', 'molecular-O', 'layer-O', 'of-O', 'the-O', 'dentate-O', 'gyrus-O', '(-O', 'IML-O', ')-O', 'of-O', 'rats-O', 'subject-O', 'to-O', 'status-B-Disease', 'epilepticus-I-Disease', 'induced-O', 'by-O', 'pilocarpine-B-Chemical', '(-O', 'Pilo-O', ')-O', 'previously-O', 'injected-O', 'or-O', 'not-O', 'with-O', 'cycloheximide-B-Chemical', '(-O', 'CHX-O', ')-O', 'which-O', 'has-O', 'been-O', 'shown-O', 'to-O', 'inhibit-O', 'MFS-O', '.-O']
['METHODS-O', ':-O', 'CHX-B-Chemical', 'was-O', 'injected-O', 'before-O', 'the-O', 'Pilo-B-Chemical', 'injection-O', 'in-O', 'adult-O', 'Wistar-O', 'rats-O', '.-O']
['The-O', 'Pilo-O', 'group-O', 'was-O', 'injected-O', 'with-O', 'the-O', 'same-O', 'drugs-O', ',-O', 'except-O', 'for-O', 'CHX-B-Chemical', '.-O']
['Animals-O', 'were-O', 'killed-O', 'between-O', '30-O', 'and-O', '60-O', 'days-O', 'later-O', ',-O', 'and-O', 'brain-O', 'sections-O', 'were-O', 'processed-O', 'for-O', 'GAP43-B-Chemical', 'immunohistochemistry-O', '.-O']
['RESULTS-O', ':-O', 'Densitometry-O', 'showed-O', 'no-O', 'significant-O', 'difference-O', 'regarding-O', 'GAP43-O', ',-O', 'ir-O', 'in-O', 'the-O', 'IML-O', 'between-O', 'Pilo-O', ',-O', 'CHX-O', '+-O', 'Pilo-O', ',-O', 'and-O', 'control-O', 'groups-O', '.-O']
['However-O', ',-O', 'the-O', 'results-O', 'of-O', 'the-O', 'width-O', 'of-O', 'the-O', 'GAP43-B-Chemical', ',-O', 'ir-O', 'band-O', 'in-O', 'the-O', 'IML-O', 'showed-O', 'that-O', 'CHX-B-Chemical', '+-O', 'Pilo-B-Chemical', 'and-O', 'control-O', 'animals-O', 'had-O', 'a-O', 'significantly-O', 'larger-O', 'band-O', '(-O', 'p-O', '=O', '0-O', '.-O']
['03-O', ')-O', 'as-O', 'compared-O', 'with-O', 'that-O', 'in-O', 'the-O', 'Pilo-B-Chemical', 'group-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Our-O', 'current-O', 'finding-O', 'that-O', 'animals-O', 'in-O', 'the-O', 'CHX-B-Chemical', '+-O', 'Pilo-B-Chemical', 'group-O', 'have-O', 'a-O', 'GAP43-B-Chemical', ',-O', 'ir-O', 'band-O', 'in-O', 'the-O', 'IML-O', ',-O', 'similar-O', 'to-O', 'that-O', 'of-O', 'controls-O', ',-O', 'reinforces-O', 'prior-O', 'data-O', 'on-O', 'the-O', 'blockade-O', 'of-O', 'MFS-B-Disease', 'in-O', 'these-O', 'animals-O', '.-O']
['The-O', 'change-O', 'in-O', 'GAP43-O', ',-O', 'ir-O', 'present-O', 'in-O', 'Pilo-O']
['Nicotine-B-Chemical', 'antagonizes-O', 'caffeine-B-Chemical', ',-O', 'but-O', 'not-O', 'pentylenetetrazole-B-Chemical', ',-O', 'induced-O', 'anxiogenic-O', 'effect-O', 'in-O', 'mice-O', '.-O']
['RATIONALE-O', ':-O', 'Nicotine-B-Chemical', 'and-O', 'caffeine-B-Chemical', 'are-O', 'widely-O', 'consumed-O', 'licit-O', 'psychoactive-O', 'drugs-O', 'worldwide-O', '.-O']
['Epidemiological-O', 'studies-O', 'showed-O', 'that-O', 'they-O', 'were-O', 'generally-O', 'used-O', 'concurrently-O', '.-O']
['Although-O', 'some-O', 'studies-O', 'in-O', 'experimental-O', 'animals-O', 'indicate-O', 'clear-O', 'pharmacological-O', 'interactions-O', 'between-O', 'them-O', ',-O', 'no-O', 'studies-O', 'have-O', 'shown-O', 'a-O', 'specific-O', 'interaction-O', 'on-O', 'anxiety-O', 'responses-O', '.-O']
['OBJECTIVES-O', ':-O', 'The-O', 'present-O', 'study-O', 'investigates-O', 'the-O', 'effects-O', 'of-O', 'nicotine-B-Chemical', 'on-O', 'anxiety-B-Disease', 'induced-O', 'by-O', 'caffeine-B-Chemical', 'and-O', 'another-O', 'anxiogenic-O', 'drug-O', ',-O', 'pentylenetetrazole-B-Chemical', ',-O', 'in-O', 'mice-O', '.-O']
['The-O', 'elevated-O', 'plus-O', 'maze-O', '(-O', 'EPM-O', ')-O', 'test-O', 'was-O', 'used-O', 'to-O', 'evaluate-O', 'the-O', 'effects-O', 'of-O', 'drugs-O', 'on-O', 'anxiety-B-Disease', '.-O']
['METHODS-O', ':-O', 'Adult-O', 'male-O', 'Swiss-O', 'Webster-O', 'mice-O', '(-O', '25-O', ',-O', '32-O', 'g-O', ')-O', 'were-O', 'given-O', 'nicotine-B-Chemical', '(-O', '0-O', '.-O']
['05-O', ',-O', '0-O', '.-O']
['25-O', 'mg-O', '/-O', 'kg-O', 's-O', '.-O']
['c-O', ')-O', 'or-O', 'saline-O', '10-O', 'min-O', 'before-O', 'caffeine-B-Chemical', '(-O', '70-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', ')-O', 'or-O', 'pentylenetetrazole-B-Chemical', '(-O', '15-O', 'and-O', '30-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', ')-O', 'injections-O', '.-O']
['After-O', '15-O', 'min-O', ',-O', 'mice-O', 'were-O', 'evaluated-O', 'for-O', 'their-O', 'open-O', ',-O', 'and-O', 'closed-O', ',-O', 'arm-O', 'time-O', 'and-O', 'entries-O', 'on-O', 'the-O', 'EPM-O', 'for-O', 'a-O', '10-O', ',-O', 'min-O', 'session-O', '.-O']
['Locomotor-O', 'activity-O', 'was-O', 'recorded-O', 'for-O', 'individual-O', 'groups-O', 'by-O', 'using-O', 'the-O', 'same-O', 'treatment-O', 'protocol-O', 'with-O', 'the-O', 'EPM-O', 'test-O', '.-O']
['RESULTS-O', ':-O', 'Nicotine-B-Chemical', '(-O', '0-O', '.-O']
['05-O', ',-O', '0-O', '.-O']
['25-O', 'mg-O', '/-O', 'kg-O', ')-O', 'itself-O', 'did-O', 'not-O', 'produce-O', 'any-O', 'significant-O', 'effect-O', 'in-O', 'the-O', 'EPM-O', 'test-O', ',-O', 'whereas-O', 'caffeine-B-Chemical', '(-O', '70-O', 'mg-O', '/-O', 'kg-O', ')-O', 'and-O', 'pentylenetetrazole-B-Chemical', '(-O', '30-O', 'mg-O', '/-O', 'kg-O', ')-O', 'produced-O', 'an-O', 'anxiogenic-B-Disease', 'effect-O', ',-O', 'apparent-O', 'with-O', 'decreases-O', 'in-O', 'open-O', ',-O', 'arm-O', 'time-O', 'and-O', 'entry-O', '.-O']
['Nicotine-B-Chemical', '(-O', '0-O', '.-O']
['25-O', 'mg-O', '/-O', 'kg-O', ')-O', 'pretreatment-O', 'blocked-O', 'the-O', 'caffeine-B-Chemical', ',-O', 'but-O', 'not-O', 'pentylenetetrazole-B-Chemical', ',-O', 'induced-O', 'anxiety-B-Disease', '.-O']
['Administration-O', 'of-O', 'each-O', 'drug-O', 'and-O', 'their-O', 'combinations-O', 'did-O', 'not-O', 'produce-O', 'any-O', 'effect-O', 'on-O', 'locomotor-O', 'activity-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Our-O', 'results-O', 'suggest-O', 'that-O', 'the-O', 'antagonistic-O', 'effect-O', 'of-O', 'nicotine-B-Chemical', 'on-O', 'caffeine-B-Chemical', ',-O', 'induced-O', 'anxiety-B-Disease', 'is-O', 'specific-O', 'to-O', 'caffeine-B-Chemical', ',-O', 'instead-O', 'of-O', 'a-O', 'non-O', ',-O', 'specific-O', 'anxiolytic-O', 'effect-O', '.-O']
['Thus-O', ',-O', 'it-O', 'may-O', 'extend-O', 'the-O', 'current-O', 'findings-O', 'on-O', 'the-O', 'interaction-O', 'between-O', 'nicotine-B-Chemical', 'and-O', 'caffeine-B-Chemical']
['Long-O', 'term-O', 'hormone-B-Chemical', 'therapy-O', 'for-O', 'perimenopausal-O', 'and-O', 'postmenopausal-O', 'women-O', '.-O']
['BACKGROUND-O', ':-O', 'Hormone-O', 'therapy-O', '(-O', 'HT-O', ')-O', 'is-O', 'widely-O', 'used-O', 'for-O', 'controlling-O', 'menopausal-B-Disease', 'symptoms-O', '.-O']
['It-O', 'has-O', 'also-O', 'been-O', 'used-O', 'for-O', 'the-O', 'management-O', 'and-O', 'prevention-O', 'of-O', 'cardiovascular-B-Disease', ',', 'osteoporosis-B-Disease', 'and-O', 'dementia-B-Disease', 'in-O', 'older-O', 'women-O', 'but-O', 'the-O', 'evidence-O', 'supporting-O', 'its-O', 'use-O', 'for-O', 'these-O', 'indications-O', 'is-O', 'largely-O', 'observational-O', '.-O']
['OBJECTIVES-O', ':-O', 'To-O', 'assess-O', 'the-O', 'effect-O', 'of-O', 'long-O', ',-O', 'term-O', 'HT-O', 'on-O', 'mortality-O', ',-O', 'heart-O', 'disease-B-Disease', ',-O', 'venous-B-Disease', 'thromboembolism-I-Disease', ',-O', 'stroke-B-Disease', ',-O', 'transient-O', 'ischaemic-O', 'attacks-O', ',-O', 'breast-B-Disease', 'cancer-I-Disease', ',-O', 'colorectal-B-Disease', 'cancer-I-Disease', ',-O', 'ovarian-B-Disease', 'cancer-I-Disease', ',-O', 'endometrial-B-Disease', 'cancer-I-Disease', ',-O', 'gallbladder-B-Disease', 'disease-I-Disease', ',-O', 'cognitive-O', 'function-O', ',-O', 'dementia-B-Disease', ',-O', 'fractures-O', 'and-O', 'quality-O', 'of-O', 'life-O', '.-O']
['SEARCH-O', 'STRATEGY-O', ':-O', 'We-O', 'searched-O', 'the-O', 'following-O', 'databases-O', 'up-O', 'to-O', 'November-O', '2004-O', ':-O', 'the-O', 'Cochrane-O', 'Menstrual-O', 'Disorders-O', 'and-O', 'Subfertility-O', 'Group-O', 'Trials-O', 'Register-O', ',-O', 'Cochrane-O', 'Central-O', 'Register-O', 'of-O', 'Controlled-O', 'Trials-O', '(-O', 'CENTRAL-O', ')-O', ',-O', 'MEDLINE-O', ',-O', 'EMBASE-O', ',-O', 'Biological-O', 'Abstracts-O', '.-O']
['Relevant-O', 'non-O', ',-O', 'indexed-O', 'journals-O', 'and-O', 'conference-O', 'abstracts-O', 'were-O', 'also-O', 'searched-O', '.-O']
['SELECTION-O', 'CRITERIA-O', ':-O', 'Randomised-O', 'double-O', ',-O', 'blind-O', 'trials-O', 'of-O', 'HT-O', '(-O', 'oestrogens-B-Chemical', 'with-O', 'or-O', 'without-O', 'progestogens-B-Chemical', ')-O', 'versus-O', 'placebo-O', ',-O', 'taken-O', 'for-O', 'at-O', 'least-O', 'one-O', 'year-O', 'by-O', 'perimenopausal-O', 'or-O', 'postmenopausal-O', 'women-O', '.-O']
['DATA-O', 'COLLECTION-O', 'AND-O', 'ANALYSIS-O', ':-O', 'Fifteen-O', 'RCTs-O', 'were-O', 'included-O', '.-O']
['Trials-O', 'were-O', 'assessed-O', 'for-O', 'quality-O', 'and-O', 'two-O', 'review-O', 'authors-O', 'extracted-O', 'data-O', 'independently-O', '.-O']
['They-O', 'calculated-O', 'risk-O', 'ratios-O', 'for-O', 'dichotomous-O', 'outcomes-O', 'and-O', 'weighted-O', 'mean-O', 'differences-O', 'for-O', 'continuous-O', 'outcomes-O', '.-O']
['Clinical-O', 'heterogeneity-O', 'precluded-O', 'meta-O', 'analysis-O', 'for-O', 'most-O', 'outcomes-O', '.-O']
['MAIN-O', 'RESULTS-O', ':-O', 'All-O', 'the-O', 'statistically-O', 'significant-O', 'results-O', 'were-O', 'derived-O', 'from-O', 'the-O', 'two-O', 'biggest-O', 'trials-O', '.-O']
['In-O', 'relatively-O', 'healthy-O', 'women-O', ',-O', 'combined-O', 'continuous-O', 'HT-O', 'significantly-O', 'increased-O', 'the-O', 'risk-O', 'of-O', 'venous-B-Disease', 'thromboembolism-I-Disease', 'or-O', 'coronary-O', 'event-O', '(-O', 'after-O', 'one-O', 'year-O', 'x-O', 's-O', 'use-O', ')-O', 'stroke-B-Disease', '(-O', 'after-O', '3-O', 'years-O', ')-O', 'breast-B-Disease', 'cancer-I-Disease', '(-O', 'after-O', '5-O', 'years-O', ')-O', 'and-O', 'gallbladder-B-Disease', 'disease-I-Disease', '.-O']
['Long-O', '-O', 'term-O', 'oestrogen-B-Chemical', '-O', 'only-O', 'HT-O', 'also-O', 'significantly-O', 'increased-O', 'the-O', 'risk-O', 'of-O', 'stroke-B-Disease', 'and-O', 'gallbladder-B-Disease', 'disease-I-Disease', '.-O']
['Overall-O', ',-O', 'the-O', 'only-O', 'statistically-O', 'significant-O', 'benefits-O', 'of-O', 'HT-O', 'were-O', 'a-O', 'decreased-O', 'incidence-O', 'of-O', 'fractures-B-Disease', 'and-O', 'colon-B-Disease', 'cancer-B-Disease', 'with-O', 'long-O', ',-O', 'term-O', 'use-O', '.-O']
['Among-O', 'relatively-O', 'healthy-O', 'women-O', 'over-O', '65-O', 'years-O', 'taking-O', 'continuous-O', 'combined-O', 'HT-O', ',-O', 'there-O', 'was-O', 'a-O', 'statistically-O', 'significant-O', 'increase-O', 'in-O', 'the-O', 'incidence-O', 'of-O', 'dementia-B-Disease', '.-O']
['Among-O', 'women-O', 'with-O', 'cardiovascular-O', 'disease-O', ',-O', 'long-O', ',-O', 'term-O', 'use-O', 'of-O', 'combined-O', 'continuous-O', 'HT-O', 'significantly-O', 'increased-O', 'the-O', 'risk-O', 'of-O', 'venous-B-Disease', 'thromboembolism-I-Disease', '.-O']
['No-O', 'trials-O', 'focussed-O', 'specifically-O', 'on-O', 'younger-O', 'women-O', '.-O']
['However-O', ',-O', 'one-O', 'trial-O', 'analysed-O', 'subgroups-O', 'of-O', '2839-O', 'relatively-O', 'healthy-O', '50-O', 'to-O', '59-O', 'year-O', ',-O', 'old-O', 'women-O', 'taking-O', 'combined-O', 'continuous-O', 'HT-B-Disease', 'and-O', '1637-O', 'taking-O', 'oestrogen-B-Chemical', ',-O', 'only-O', 'HT-B-Disease', ',-O', 'versus-O', 'similar-O', ',-O', 'sized-O', 'placebo-O', 'groups-O', '.-O']
['The-O', 'only-O', 'significantly-O', 'increased-O', 'risk-O', 'reported-O', 'was-O', 'for-O', 'venous-B-Disease', 'thromboembolism-I-Disease', 'in-O', 'women-O', 'taking-O', 'combined-O', 'continuous-O', 'HT-O', ';-O', 'their-O', 'absolute-O', 'risk-O', 'remained-O', 'very-O', 'low-O', '.-O']
['AUTHORS-O', 'x-O', 'CONCLUSIONS-O', ':-O', 'HT-B-Disease', 'is-O', 'not-O', 'indicated-O', 'for-O', 'the-O', 'routine-O', 'management-O', 'of-O', 'chronic-O', 'disease-O']
['Drug-induced-O', 'liver-B-Disease', 'injury-I-Disease', ':-O', 'an-O', 'analysis-O', 'of-O', '461-O', 'incidences-O', 'submitted-O', 'to-O', 'the-O', 'Spanish-O', 'registry-O', 'over-O', 'a-O', '10-O', ',-O', 'year-O', 'period-O', '.-O']
['BACKGROUND-O', '&-O', 'AIMS-O', ':-O', 'Progress-O', 'in-O', 'the-O', 'understanding-O', 'of-O', 'susceptibility-O', 'factors-O', 'to-O', 'drug-induced-O', 'liver-O', 'injury-O', '(-O', 'DILI-B-Disease', ')-O', 'and-O', 'outcome-O', 'predictability-O', 'are-O', 'hampered-O', 'by-O', 'the-O', 'lack-O', 'of-O', 'systematic-O', 'programs-O', 'to-O', 'detect-O', 'bona-O', 'fide-O', 'cases-O', '.-O']
['METHODS-O', ':-O', 'A-O', 'cooperative-O', 'network-O', 'was-O', 'created-O', 'in-O', '1994-O', 'in-O', 'Spain-O', 'to-O', 'identify-O', 'all-O', 'suspicions-O', 'of-O', 'DILI-B-Disease', 'following-O', 'a-O', 'prospective-O', 'structured-O', 'report-O', 'form-O', '.-O']
['The-O', 'liver-O', 'damage-O', 'was-O', 'characterized-O', 'according-O', 'to-O', 'hepatocellular-B-Disease', ',-O', 'cholestatic-B-Disease', ',-O', 'and-O', 'mixed-O', 'laboratory-O', 'criteria-O', 'and-O', 'to-O', 'histologic-O', 'criteria-O', 'when-O', 'available-O', '.-O']
['Further-O', 'evaluation-O', 'of-O', 'causality-O', 'assessment-O', 'was-O', 'centrally-O', 'performed-O', '.-O']
['RESULTS-O', ':-O', 'Since-O', 'April-O', '1994-O', 'to-O', 'August-O', '2004-O', ',-O', '461-O', 'out-O', 'of-O', '570-O', 'submitted-O', 'cases-O', ',-O', 'involving-O', '505-O', 'drugs-O', ',-O', 'were-O', 'deemed-O', 'to-O', 'be-O', 'related-O', 'to-O', 'DILI-B-Disease', '.-O']
['The-O', 'antiinfective-O', 'group-O', 'of-O', 'drugs-O', 'was-O', 'the-O', 'more-O', 'frequently-O', 'incriminated-O', ',-O', 'amoxicillin-clavulanate-B-Chemical', 'accounting-O', 'for-O', 'the-O', '12-O', '.-O']
['8-O', '%-O', 'of-O', 'the-O', 'whole-O', 'series-O', '.-O']
['The-O', 'hepatocellular-O', 'pattern-O', 'of-O', 'damage-O', 'was-O', 'the-O', 'most-O', 'common-O', '(-O', '58-O', ')-O', 'was-O', 'inversely-O', 'correlated-O', 'with-O', 'age-O', '(-O', 'P-O', '<.-O', '0001-O', ')-O', 'and-O', 'had-O', 'the-O', 'worst-O', 'outcome-O', '(-O', 'Cox-O', 'regression-O', ',-O', 'P-O', '<.-O', '034-O', ')-O', '.-O', 'Indeed-O', ',-O', 'the-O', 'incidence-O', 'of-O', 'liver-O', 'transplantation-O', 'and-O', 'death-B-Disease', 'in-O', 'this-O', 'group-O', 'was-O', '11-O', '.-O']
['7-O', '%-O', 'if-O', 'patients-O', 'had-O', 'jaundice-B-Disease', 'at-O', 'presentation-O', ',-O', 'whereas-O', 'the-O', 'corresponding-O', 'figure-O', 'was-O', '3-O', '.-O']
['8-O', '%-O', 'in-O', 'nonjaundiced-O', 'patients-O', '(-O', 'P-O', '<.-O', '04-O', ').-O', 'Factors-O', 'associated-O', 'with-O', 'the-O', 'development-O', 'of-O', 'fulminant-B-Disease', 'hepatic-B-Disease', 'failure-I-Disease', 'were-O', 'female-O', 'sex-O', '(-O', 'OR-O', '=-O', '25-O', ';-O', '95-O', '%-O', 'CI-O', ':-O', '4-O', '.-O']
['1-O', ',-O', '151-O', ';-O', 'P-O', '<.-O', '0001-O', ')-O', 'hepatocellular-B-Disease', 'damage-I-Disease', '(-O', 'OR-O', '='-O', '7-O', '.-O']
['9-O', ';-O', '95-O', '%-O', 'CI-O', ':-O', '1-O', '.-O']
['6-O', ',-O', '37-O', ';-O', 'P-O', '<.-O', '009-O', ')-O', 'and-O', 'higher-O', 'baseline-O', 'plasma-O', 'bilirubin-B-Chemical', 'value-O', '(-O', 'OR-O', '=-O', '1-O', '.-O']
['15-O', ';-O', '95-O', '%-O', 'CI-O', ':-O', '1-O', '.-O']
['09-O', ',-O', '1-O', '.-O']
['22-O', ';-O', 'P-O', '<.-O', '0001-O', ')-O', 'CONCLUSIONS-O', ':-O', 'Patients-O', 'with-O', 'drug-O', ',-O', 'induced-O', 'hepatocellular-O', 'jaundice-B-Disease', 'have-O', '11-O', '.-O']
['7-O', '%-O', 'chance-O', 'of-O', 'progressing-O', 'to-O', 'death-B-Disease', 'or-O', 'transplantation-O', '.-O']
['Amoxicillin-clavulanate-B-Chemical', 'stands-O', 'out-O', 'as-O', 'the-O', 'most-O', 'common-O', 'drug-O', 'related-O', 'to-O', 'DILI-B-Disease', 'I-Disease']
['Morphological-O', 'evaluation-O', 'of-O', 'the-O', 'effect-O', 'of-O', 'd-ribose-B-Chemical', 'on-O', 'adriamycin-B-Chemical', ',-O', 'evoked-O', 'cardiotoxicity-B-Disease', 'in-O', 'rats-O', '.-O']
['The-O', 'influence-O', 'of-O', 'd-ribose-B-Chemical', 'on-O', 'adriamycin-B-Chemical', ',-O', 'induced-O', 'myocardiopathy-B-Disease', 'in-O', 'rats-O', 'was-O', 'studied-O', '.-O']
['Adriamycin-B-Chemical', 'in-O', 'the-O', 'cumulative-O', 'dose-O', 'of-O', '25-O', 'mg-O', '/-O', 'kg-O', 'evoked-O', 'fully-O', 'developed-O', 'cardiac-B-Disease', 'toxicity-I-Disease', '.-O']
['D-ribose-B-Chemical', 'in-O', 'the-O', 'multiple-O', 'doses-O', 'of-O', '200-O', 'mg-O', '/-O', 'kg-O', 'did-O', 'not-O', 'influence-O', 'ADR-B-Disease', 'cardiotoxicity-I-Disease']
['In-O', 'vivo-O', 'evidences-O', 'suggesting-O', 'the-O', 'role-O', 'of-O', 'oxidative-O', 'stress-O', 'in-O', 'pathogenesis-O', 'of-O', 'vancomycin-B-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease', ':-O', 'protection-O', 'by-O', 'erdosteine-B-Chemical', '.-O']
['The-O', 'aims-O', 'of-O', 'this-O', 'study-O', 'were-O', 'to-O', 'examine-O', 'vancomycin-B-Chemical', '(-O', 'VCM-B-Chemical', ')-O', 'induced-O', 'oxidative-O', 'stress-O', 'that-O', 'promotes-O', 'production-O', 'of-O', 'reactive-O', 'oxygen-B-Chemical', 'species-O', '(-O', 'ROS-O', ')-O', 'and-O', 'to-O', 'investigate-O', 'the-O', 'role-O', 'of-O', 'erdosteine-B-Chemical', ',-O', 'an-O', 'expectorant-O', 'agent-O', ',-O', 'which-O', 'has-O', 'also-O', 'antioxidant-O', 'properties-O', ',-O', 'on-O', 'kidney-O', 'tissue-O', 'against-O', 'the-O', 'possible-O', 'VCM-B-Chemical', ',-O', 'induced-O', 'renal-O', 'impairment-O', 'in-O', 'rats-O', '.-O']
['Rats-O', 'were-O', 'divided-O', 'into-O', 'three-O', 'groups-O', ':-O', 'sham-O', ',-O', 'VCM-O', 'and-O', 'VCM-O', 'plus-O', 'erdosteine-B-Chemical', '.-O']
['VCM-B-Chemical', 'was-O', 'administrated-O', 'intraperitoneally-O', '(-O', 'i-O', '.-O']
['p-O', ')-O', 'with-O', '200mgkg-O', '(-O', '1-O', ')-O', 'twice-O', 'daily-O', 'for-O', '7-O', 'days-O', '.-O']
['Erdosteine-B-Chemical', 'was-O', 'administered-O', 'orally-O', '.-O']
['VCM-B-Chemical', 'administration-O', 'to-O', 'control-O', 'rats-O', 'significantly-O', 'increased-O', 'renal-O', 'malondialdehyde-B-Chemical', '(-O', 'MDA-B-Chemical', ')-O', 'and-O', 'urinary-O', 'N-O', ',', 'acetyl-O', ',', 'beta-O', ',', 'd-O', ',', 'glucosaminidase-O', '(-O', 'NAG-B-Chemical', ',-O', 'a-O', 'marker-O', 'of-O', 'renal-O', 'tubular-O', 'injury-O', ')-O', 'excretion-O', 'but-O', 'decreased-O', 'superoxide-O', 'dismutase-O', '(-O', 'SOD-B-Chemical', ')-O', 'and-O', 'catalase-O', '(-O', 'CAT-B-Chemical', ')-O', 'activities-O', '.-O']
['Erdosteine-B-Chemical', 'administration-O', 'with-O', 'VCM-B-Chemical', 'injections-O', 'caused-O', 'significantly-O', 'decreased-O', 'renal-O', 'MDA-B-Chemical', 'and-O', 'urinary-O', 'NAG-B-Chemical', 'excretion-O', ',-O', 'and-O', 'increased-O', 'SOD-B-Chemical', 'activity-O', ',-O', 'but-O', 'not-O', 'CAT-B-Chemical', 'activity-O', 'in-O', 'renal-O', 'tissue-O', 'when-O', 'compared-O', 'with-O', 'VCM-B-Chemical', 'alone-O', '.-O']
['Erdosteine-B-Chemical', 'showed-O', 'histopathological-O', 'protection-O', 'against-O', 'VCM-B-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease', '.-O']
['There-O', 'were-O', 'a-O', 'significant-O', 'dilatation-O', 'of-O', 'tubular-O', 'lumens-O', ',-O', 'extensive-O', 'epithelial-O', 'cell-O', 'vacuolization-O', ',-O', 'atrophy-B-Disease', ',-O', 'desquamation-O', ',-O', 'and-O', 'necrosis-B-Disease', 'in-O', 'VCM-O', 'treated-O', 'rats-O', 'more-O', 'than-O', 'those-O', 'of-O', 'the-O', 'control-O', 'and-O', 'the-O', 'erdosteine-B-Chemical', 'groups-O', '.-O']
['Erdosteine-B-Chemical', 'caused-O', 'a-O', 'marked-O', 'reduction-O', 'in-O', 'the-O', 'extent-O', 'of-O', 'tubular-O', 'damage-O', '.-O']
['It-O', 'is-O', 'concluded-O', 'that-O', 'oxidative-O', 'tubular-O', 'damage-O', 'plays-O', 'an-O', 'important-O', 'role-O', 'in-O', 'the-O', 'VCM-B-Chemical', ',-O', 'induced-O', 'nephrotoxicity-B-Disease', 'and-O', 'the-O', 'modulation-O', 'of-O', 'oxidative-O', 'stress-O', 'with-O', 'erdosteine-B-Chemical', 'reduces-O', 'the-O', 'VCM-B-Chemical', ',-O', 'induced-O', 'kidney-O', 'damage-O']
['Does-O', 'domperidone-B-Chemical', 'potentiate-O', 'mirtazapine-B-Chemical', ',-O', 'associated-O', 'restless-O', 'legs-O', 'syndrome-B-Disease', '?', 'There-O', 'is-O', 'now-O', 'evidence-O', 'to-O', 'suggest-O', 'a-O', 'central-O', 'role-O', 'for-O', 'the-O', 'dopaminergic-O', 'system-O', 'in-O', 'restless-O', 'legs-O', 'syndrome-B-Disease', '(-O', 'RLS-O', ')-O', '.', 'For-O', 'example-O', ',-O', 'the-O', 'symptoms-O', 'of-O', 'RLS-O', 'can-O', 'be-O', 'dramatically-O', 'improved-O', 'by-O', 'levodopa-B-Chemical', 'and-O', 'dopamine-B-Chemical', 'agonists-O', ',-O', 'whereas-O', 'central-O', 'dopamine-B-Chemical', 'D2-O', 'receptor-O', 'antagonists-O', 'can-O', 'induce-O', 'or-O', 'aggravate-O', 'RLS-O', 'symptoms-O', '.-O']
['To-O', 'our-O', 'knowledge-O', ',-O', 'there-O', 'is-O', 'no-O', 'previous-O', 'report-O', 'regarding-O', 'whether-O', 'domperidone-B-Chemical', ',-O', 'a-O', 'peripheral-O', 'dopamine-B-Chemical', 'D2-O', 'receptor-O', 'antagonist-O', ',-O', 'can-O', 'also-O', 'induce-O', 'or-O', 'aggravate-O', 'symptoms-O', 'of-O', 'RLS-B-Disease', '.-O']
['Mirtazapine-B-Chemical', ',-O', 'the-O', 'first-O', 'noradrenergic-O', 'and-O', 'specific-O', 'serotonergic-O', 'antidepressant-B-Chemical', '(-O', 'NaSSA-O', ')-O', 'has-O', 'been-O', 'associated-O', 'with-O', 'RLS-B-Disease', 'in-O', 'several-O', 'recent-O', 'publications-O', '.-O']
['The-O', 'authors-O', 'report-O', 'here-O', 'a-O', 'depressed-B-Disease', 'patient-O', 'comorbid-O', 'with-O', 'postprandial-B-Disease', 'dyspepsia-I-Disease', 'who-O', 'developed-O', 'RLS-B-Disease', 'after-O', 'mirtazapine-B-Chemical', 'had-O', 'been-O', 'added-O', 'to-O', 'his-O', 'domperidone-B-Chemical', 'therapy-O', '.-O']
['Our-O', 'patient-O', 'started-O', 'to-O', 'have-O', 'symptoms-O', 'of-O', 'RLS-B-Disease', 'only-O', 'after-O', 'he-O', 'had-O', 'been-O', 'treated-O', 'with-O', 'mirtazapine-B-Chemical', ',-O', 'and-O', 'his-O', 'RLS-B-Disease', 'symptoms-O', 'resolved-O', 'completely-O', 'upon-O', 'discontinuation-O', 'of-O', 'his-O', 'mirtazapine-B-Chemical', '.-O']
['Such-O', 'a-O', 'temporal-O', 'relationship-O', 'between-O', 'the-O', 'use-O', 'of-O', 'mirtazapine-B-Chemical', 'and-O', 'the-O', 'symptoms-O', 'of-O', 'RLS-B-Disease', 'in-O', 'our-O', 'patient-O', 'did-O', 'not-O', 'support-O', 'a-O', 'potentiating-O', 'effect-O', 'of-O', 'domperione-B-Chemical', 'on-O', 'mirtazapine-B-Chemical', ',-O', 'associated-O', 'RLS-B-Disease', '.-O']
['However-O', ',-O', 'physicians-O', 'should-O', 'be-O', 'aware-O', 'of-O', 'the-O', 'possibility-O', 'that-O', 'mirtazapine-B-Chemical', 'can-O', 'be-O', 'associated-O', 'with-O', 'RLS-B-Disease', 'in-O', 'some-O', 'individuals-O', ',-O', 'especially-O', 'those-O', 'receiving-O', 'concomitant-O', 'dopamine-B-Chemical']
['Antiandrogenic-O', 'therapy-O', 'can-O', 'cause-O', 'coronary-B-Disease', 'arterial-I-Disease', 'disease-I-Disease', '.-O']
['AIM-O', ':-O', 'To-O', 'study-O', 'the-O', 'change-O', 'of-O', 'lipid-O', 'metabolism-O', 'by-O', 'antiandrogen-B-Chemical', 'therapy-O', 'in-O', 'patients-O', 'with-O', 'prostate-B-Disease', 'cancer-I-Disease', '.-O']
['MATERIALS-O', 'AND-O', 'METHODS-O', ':-O', 'We-O', 'studied-O', 'with-O', 'a-O', '2-O', '.-O']
['5-O', 'years-O', 'follow-O', ',-O', 'up-O', 'the-O', 'changes-O', 'in-O', 'plasma-O', 'cholesterols-O', '(-O', 'C-O', ')-O', 'triglycerides-O', '(-O', 'TG-O', ')-O', 'lipoproteins-O', '(-O', 'LP-O', ')-O', 'and-O', 'apolipoproteins-O', '(-O', 'Apo-O', ')-O', 'B-O', '-O', '100-O', '-O', 'A-O', '-O', 'I-O', '-O', 'and-O', 'A-O', '-O', 'II-O', 'pro-O', 'fi-O', 'les-O', 'in-O', '24-O', 'patients-O', 'of-O', 'mean-O', 'age-O', '60-O', 'years-O', 'with-O', 'low-O', 'risk-O', 'prostate-B-Disease', 'cancer-I-Disease', '(-O', 'stage-O', ':O', 'T1cN0M0-O', '-O', 'Gleason-O', 'score-O', ':O', '2-O', '-O', '5-O', ')-O', 'during-O', 'treatment-O', 'with-O', 'cyproterone-B-Chemical', 'acetate-I-Chemical', '(-O', 'CPA-B-Chemical', ')-O', 'without-O', 'surgical-O', 'management-O', 'or-O', 'radiation-O', 'therapy-O', '.-O']
['RESULTS-O', ':-O', 'Significant-O', 'decreases-O', 'of-O', 'HDL-B-Chemical', ',-O', 'C-B-Chemical', ',-O', 'Apo-B-Chemical', 'A-O', ',-O', 'I-O', 'and-O', 'Apo-B-Chemical', 'A-O', ',-O', 'II-O', 'and-O', 'an-O', 'increase-O', 'of-O', 'triglyceride-B-Chemical', 'levels-O', 'in-O', 'VLDL-B-Chemical', 'were-O', 'induced-O', 'by-O', 'CPA-B-Chemical', '.-O']
['After-O', 'a-O', 'period-O', 'of-O', '2-O', '.-O']
['5-O', 'years-O', 'on-O', 'CPA-B-Chemical', 'treatment-O', ',-O', 'four-O', 'patients-O', 'out-O', 'of-O', 'twenty-O', ',-O', 'four-O', 'were-O', 'found-O', 'to-O', 'be-O', 'affected-O', 'by-O', 'coronary-B-Disease', 'heart-I-Disease', 'disease-I-Disease', '.-O']
['CONCLUSIONS-O', ':-O', 'Ischaemic-B-Disease', 'coronary-O', 'arteriosclerosis-I-Disease', 'with-O', 'an-O', 'incidence-O', 'rate-O', 'of-O', '16-O', '.-O']
['6-O', '%-O', 'as-O', 'caused-O', 'by-O', 'prolonged-O', 'CPA-B-Chemical', 'therapy-O', 'is-O', 'mediated-O', 'through-O', 'changes-O', 'in-O', 'HDL-B-Chemical', 'cholesterol-B-Chemical', ',-O', 'Apo-O', 'A-O', ',-O', 'I-O', 'and-O', 'Apo-O', 'A-O', ',-O', 'II-O', 'pro-O', 'fi-O', 'les-O', ',-O', 'other-O', 'than-O', 'the-O', 'well-O', ',-O', 'known-O', 'hyperglyceridemic-O', 'effect-O', 'caused-O', 'by-O', 'estrogen-B-Chemical']
['5-Fluorouracil-B-Chemical', 'cardiotoxicity-B-Disease', 'induced-O', 'by-O', 'alpha-fluoro-beta-alanine-B-Chemical', '.-O']
['Cardiotoxicity-B-Disease', 'is-O', 'a-O', 'rare-O', 'complication-O', 'occurring-O', 'during-O', '5-fluorouracil-B-Chemical', '(-O', '5-FU-B-Chemical', ')-O', 'treatment-O', 'for-O', 'malignancies-O', '.-O']
['We-O', 'herein-O', 'report-O', 'the-O', 'case-O', 'of-O', 'a-O', '70-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'with-O', '5-FU-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', ',-O', 'in-O', 'whom-O', 'a-O', 'high-O', 'serum-O', 'level-O', 'of-O', 'alpha-fluoro-beta-alanine-B-Chemical', '(-O', 'FBAL-B-Chemical', ')-O', 'was-O', 'observed-O', '.-O']
['The-O', 'patient-O', ',-O', 'who-O', 'had-O', 'unresectable-O', 'colon-B-Disease', 'cancer-I-Disease', 'metastases-O', 'to-O', 'the-O', 'liver-I-Disease', 'and-O', 'lung-I-Disease', ',-O', 'was-O', 'referred-O', 'to-O', 'us-O', 'for-O', 'chemotherapy-O', 'from-O', 'an-O', 'affiliated-O', 'hospital-O', ';-O', 'he-O', 'had-O', 'no-O', 'cardiac-B-Disease', 'history-O', '.-O']
['After-O', 'admission-O', ',-O', 'the-O', 'patient-O', 'received-O', 'a-O', 'continuous-O', 'intravenous-O', 'infusion-O', 'of-O', '5-FU-B-Chemical', '(-O', '1000-O', 'mg-O', '/-O', 'day-O', ')-O', 'during-O', 'which-O', 'precordial-O', 'pain-O', 'with-O', 'right-O', 'bundle-O', 'branch-O', 'block-O', 'occurred-O', 'concomitantly-O', 'with-O', 'a-O', 'high-O', 'serum-O', 'FBAL-B-Chemical', 'concentration-O', 'of-O', '1955-O', 'ng-O', '/-O', 'ml-O', '.-O']
['Both-O', 'the-O', 'precordial-O', 'pain-B-Disease', 'and-O', 'the-O', 'electrocardiographic-O', 'changes-O', 'disappeared-O', 'spontaneously-O', 'after-O', 'the-O', 'discontinuation-O', 'of-O', '5-FU-B-Chemical', '.-O']
['As-O', 'the-O', 'precordial-O', 'pain-B-Disease', 'in-O', 'this-O', 'patient-O', 'was-O', 'considered-O', 'to-O', 'have-O', 'been-O', 'due-O', 'to-O', '5-FU-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', ',-O', 'the-O', 'administration-O', 'of-O', '5-FU-B-Chemical', 'was-O', 'abandoned-O', '.-O']
['Instead-O', ',-O', 'oral-O', 'administration-O', 'of-O', 'S-B-Chemical', ',-O', '1-O', '(-O', 'a-O', 'derivative-O', 'of-O', '5-FU-B-Chemical', ')-O', ',', 'at-O', '200-O', 'mg-O', '/-O', 'day-O', 'twice-O', 'a-O', 'week-O', ',-O', 'was-O', 'instituted-O', ',-O', 'because-O', 'S-B-Chemical', ',-O', '1-O', 'has-O', 'a-O', 'strong-O', 'inhibitory-O', 'effect-O', 'on-O', 'dihydropyrimidine-O', 'dehydrogenase-O', ',-O', 'which-O', 'catalyzes-O', 'the-O', 'degradative-O', 'of-O', '5-FU-B-Chemical', 'into-O', 'FBAL-O', '.-O']
['The-O', 'serum-O', 'FBAL-B-Chemical', 'concentration-O', 'subsequently-O', 'decreased-O', 'to-O', '352-O', 'ng-O', '/-O', 'ml-O', ',-O', 'the-O', 'same-O', 'as-O', 'the-O', 'value-O', 'measured-O', 'on-O', 'the-O', 'first-O', 'day-O', 'of-O', 'S-O', ',-O', '1-O', 'administration-O', '.-O']
['Thereafter-O', ',-O', 'no-O', 'cardiac-B-Disease', 'symptoms-O', 'were-O', 'observed-O', '.-O']
['The-O', 'patient-O', 'achieved-O', 'a-O', 'partial-O', 'response-O', '6-O', 'months-O', 'after-O', 'the-O', 'initiation-O', 'of-O', 'the-O', 'S-O', ',-O', '1-O', 'treatment-O', '.-O']
['The-O', 'experience-O', 'of-O', 'this-O', 'case-O', ',-O', 'together-O', 'with-O', 'a-O', 'review-O', 'of-O', 'the-O', 'literature-O', ',-O', 'suggests-O', 'that-O', 'FBAL-O', 'is-O', 'related-O', 'to-O', '5-FU-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', '.-O']
['S-O', ',-O', '1-O', 'may-O', 'be-O', 'administered-O', 'safely-O', 'to-O', 'patients-O', 'with-O', '5-FU-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease']
['The-O', 'influence-O', 'of-O', 'the-O', 'time-O', 'interval-O', 'between-O', 'monoHER-B-Chemical', 'and-O', 'doxorubicin-B-Chemical', 'administration-O', 'on-O', 'the-O', 'protection-O', 'against-O', 'doxorubicin-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', 'in-O', 'mice-O', '.-O']
['PURPOSE-O', ':-O', 'Despite-O', 'its-O', 'well-O', ',-O', 'known-O', 'cardiotoxicity-B-Disease', ',-O', 'the-O', 'anthracyclin-O', 'doxorubicin-B-Chemical', '(-O', 'DOX-B-Chemical', ')-O', 'continues-O', 'to-O', 'be-O', 'an-O', 'effective-O', 'and-O', 'widely-O', 'used-O', 'chemotherapeutic-O', 'agent-O', '.-O']
['DOX-B-Chemical', ',-O', 'induced-O', 'cardiac-B-Disease', 'damage-I-Disease', 'presumably-O', 'results-O', 'from-O', 'the-O', 'formation-O', 'of-O', 'free-O', 'radicals-O', 'by-O', 'DOX-B-Chemical', '.-O']
['Reactive-O', 'oxygen-B-Chemical', 'species-O', 'particularly-O', 'affect-O', 'the-O', 'cardiac-O', 'myocytes-O', 'because-O', 'these-O', 'cells-O', 'seem-O', 'to-O', 'have-O', 'a-O', 'relatively-O', 'poor-O', 'antioxidant-O', 'defense-O', 'system-O', '.-O']
['The-O', 'semisynthetic-O', 'flavonoid-O', 'monohydroxyethylrutoside-B-Chemical', '(', 'monoHER-I-Chemical', ')', 'showed-O', 'cardioprotection-O', 'against-O', 'DOX-B-Chemical', ',-O', 'induced-O', 'cardiotoxicity-B-Disease', 'through-O', 'its-O', 'radical-O', 'scavenging-O', 'and-O', 'iron-B-Chemical', 'chelating-O', 'properties-O', '.-O']
['Because-O', 'of-O', 'the-O', 'relatively-O', 'short-O', 'final-O', 'half-O', ',-O', 'life-O', 'of-O', 'monoHER-B-Chemical', '(-O', 'about-O', '30-O', 'min-O', ')-O', ',', 'it-O', 'is-O', 'expected-O', 'that-O', 'the-O', 'time-O', 'interval-O', 'between-O', 'monoHER-B-Chemical', 'and-O', 'DOX-B-Chemical', 'might-O', 'be-O', 'of-O', 'influence-O', 'on-O', 'the-O', 'cardioprotective-O', 'effect-O', 'of-O', 'monoHER-B-Chemical', '.-O']
['Therefore-O', ',-O', 'the-O', 'aim-O', 'of-O', 'the-O', 'present-O', 'study-O', 'was-O', 'to-O', 'investigate-O', 'this-O', 'possible-O', 'effect-O', '.-O']
['METHODS-O', ':-O', 'Six-O', 'groups-O', 'of-O', '6-O', 'BALB-O', '/-O', 'c-O', 'mice-O', 'were-O', 'treated-O', 'with-O', 'saline-O', ',-O', 'DOX-B-Chemical', 'alone-O', 'or-O', 'DOX-B-Chemical', '(-O', '4-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['v-O', ')-O', 'preceded-O', 'by-O', 'monoHER-B-Chemical', '(-O', '500-O', 'mg-O', '/-O', 'kg-O', 'i-O', '.-O']
['p-O', ')-O', 'with-O', 'an-O', 'interval-O', 'of-O', '10-O', ',-O', '30-O', ',-O', '60-O', 'or-O', '120-O', 'min-O', '.-O']
['After-O', 'a-O', '6-O', ',-O', 'week-O', 'treatment-O', 'period-O', 'and-O', 'additional-O', 'observation-O', 'for-O', '2-O', 'weeks-O', ',-O', 'the-O', 'mice-O', 'were-O', 'sacrificed-O', '.-O']
['Their-O', 'cardiac-O', 'tissues-O', 'were-O', 'processed-O', 'for-O', 'light-O', 'microscopy-O', ',-O', 'after-O', 'which-O', 'cardiomyocyte-O', 'damage-O', 'was-O', 'evaluated-O', 'according-O', 'to-O', 'Billingham-O', '(-O', 'in-O', 'Cancer-O', 'Treat-O', 'Rep-O', '62-O', '(-O', '6-O', '):-O', '865-O', ',-O', '872-O', ',-O', '1978-O', ')-O', '.-O', 'Microscopic-O', 'evaluation-O', 'revealed-O', 'that-O', 'treatment-O', 'with-O', 'DOX-B-Chemical', 'alone-O', 'induced-O', 'significant-O', 'cardiac-B-Disease', 'damage-O', 'in-O', 'comparison-O', 'to-O', 'the-O', 'saline-O', 'control-O', 'group-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'RESULTS-O', ':-O', 'The-O', 'number-O', 'of-O', 'damaged-O', 'cardiomyocytes-O', 'was-O', '9-O', '.-O']
['6-O', ',-O', 'fold-O', '(-O', '95-O', '%-O', 'CI-O', '4-O', '.-O']
['4-O', ',-O', '21-O', '.-O']
['0-O', ')-O', 'higher-O', 'in-O', 'mice-O', 'treated-O', 'with-O', 'DOX-B-Chemical', 'alone-O', 'than-O', 'that-O', 'in-O', 'animals-O', 'of-O', 'the-O', 'control-O', 'group-O', '.-O']
['The-O', 'ratio-O', 'of-O', 'aberrant-O', 'cardiomyocytes-O', 'in-O', 'mice-O', 'treated-O', 'with-O', 'DOX-B-Chemical', 'preceded-O', 'by-O', 'monoHER-O', 'and-O', 'those-O', 'in-O', 'mice-O', 'treated-O', 'with-O', 'saline-O', 'ranged-O', 'from-O', '1-O', '.-O']
['6-O', 'to-O', '2-O', '.-O']
['8-O', '(-O', 'mean-O', '2-O', '.-O']
['2-O', ',-O', '95-O', '%-O', 'CI-O', '1-O', '.-O']
['2-O', ',-O', '4-O', '.-O']
['1-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['019-O', ').-O', 'The-O', 'mean-O', 'protective-O', 'effect-O', 'by-O', 'adding-O', 'monoHER-O', 'before-O', 'DOX-B-Chemical', 'led-O', 'to-O', 'a-O', 'significant-O', '4-O', '.-O']
['4-O', ',-O', 'fold-O', 'reduction-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ',-O', '95-O', '%-O', 'CI-O', '2-O', '.-O']
['3-O', ',-O', '8-O', '.-O']
['2-O', ')-O', 'of-O', 'abnormal-B-Disease', 'cardiomyocytes-O', '.-O']
['This-O', 'protective-O', 'effect-O', 'did-O', 'not-O', 'depend-O', 'on-O', 'the-O', 'time-O', 'interval-O', 'between-O', 'monoHER-O', 'and-O', 'DOX-B-Chemical', 'administration-O', '(-O', 'P-O', '=', '0-O', '.-O']
['345-O', ').-O', 'CONCLUSION-O', ':-O', 'The-O', 'results-O', 'indicate-O', 'that-O', 'in-O', 'an-O', 'outpatient-O', 'clinical-O', 'setting-O', 'monoHER-O', 'may-O', 'be-O', 'administered-O', 'shortly-O', 'before-O', 'DOX-B-Chemical']
['Clinical-O', 'evaluation-O', 'of-O', 'adverse-O', 'effects-O', 'during-O', 'bepridil-B-Chemical', 'administration-O', 'for-O', 'atrial-B-Disease', 'fibrillation-I-Disease', 'and-O', 'flutter-I-Disease', '.-O']
['BACKGROUND-O', ':-O', 'Bepridil-B-Chemical', 'hydrochloride-I-Chemical', '(-O', 'Bpd-B-Chemical', ')-O', 'has-O', 'attracted-O', 'attention-O', 'as-O', 'an-O', 'effective-O', 'drug-O', 'for-O', 'atrial-B-Disease', 'fibrillation-I-Disease', '(-O', 'AF-B-Disease', ')-O', 'and-O', 'atrial-B-Disease', 'flutter-I-Disease', '(-O', 'AFL-B-Disease', ')-O', '.', 'However-O', ',-O', 'serious-O', 'adverse-O', 'effects-O', ',-O', 'including-O', 'torsade-B-Disease', 'de-O', 'pointes-I-Disease', '(-O', 'Tdp-B-Disease', ')-O', ',', 'have-O', 'been-O', 'reported-O', '.-O']
['METHODS-O', 'AND-O', 'RESULTS-O', ':-O', 'Adverse-O', 'effects-O', 'of-O', 'Bpd-B-Disease', 'requiring-O', 'discontinuation-O', 'of-O', 'treatment-O', 'were-O', 'evaluated-O', '.-O']
['Bpd-O', 'was-O', 'administered-O', 'to-O', '459-O', 'patients-O', '(-O', '361-O', 'males-O', ',-O', '63-O', '+-O', '12-O', 'years-O', 'old-O', ')-O', 'comprising-O', '378-O', 'AF-B-Disease', 'and-O', '81-O', 'AFL-B-Disease', 'cases-O', '.-O']
['Mean-O', 'left-O', 'ventricular-O', 'ejection-O', 'fraction-O', 'and-O', 'atrial-O', 'dimension-O', '(-O', 'LAD-O', ')-O', 'were-O', '66-O', '+-O', '11-O', '%-O', 'and-O', '40-O', '+-O', '6-O', 'mm-O', ',-O', 'respectively-O', '.-O']
['Adverse-O', 'effects-O', 'were-O', 'observed-O', 'in-O', '19-O', 'patients-O', '(-O', '4-O', ')-O', 'during-O', 'an-O', 'average-O', 'follow-O', ',-O', 'up-O', 'of-O', '20-O', 'months-O', '.-O']
['There-O', 'was-O', 'marked-O', 'QT-O', 'prolongation-B-Disease', 'greater-O', 'than-O', '0-O', '.-O']
['55-O', 's-O', 'in-O', '13-O', 'patients-O', ',-O', 'bradycardia-B-Disease', 'less-O', 'than-O', '40-O', 'beats-O', '/-O', 'min-O', 'in-O', '6-O', 'patients-O', ',-O', 'dizziness-B-Disease', 'and-O', 'general-O', 'fatigue-B-Disease', 'in-O', '1-O', 'patient-O', 'each-O', '.-O']
['In-O', '4-O', 'of-O', '13-O', 'patients-O', 'with-O', 'QT-O', 'prolongation-I-Disease', ',-O', 'Tdp-B-Disease', 'occurred-O', '.-O']
['The-O', 'major-O', 'triggering-O', 'factors-O', 'of-O', 'Tdp-B-Disease', 'were-O', 'hypokalemia-B-Disease', 'and-O', 'sudden-O', 'decrease-O', 'in-O', 'heart-O', 'rate-O', '.-O']
['There-O', 'were-O', 'no-O', 'differences-O', 'in-O', 'the-O', 'clinical-O', 'backgrounds-O', 'of-O', 'the-O', 'patients-O', 'with-O', 'and-O', 'without-O', 'Tdp-B-Disease', 'other-O', 'than-O', 'LAD-O', 'and-O', 'age-O', ',-O', 'which-O', 'were-O', 'larger-O', 'and-O', 'older-O', 'in-O', 'the-O', 'patients-O', 'with-O', 'Tdp-B-Disease', '.-O']
['CONCLUSION-O', ':-O', 'Careful-O', 'observation-O', 'of-O', 'serum-O', 'potassium-B-Chemical', 'concentration-O', 'and-O', 'the-O', 'ECG-O', 'should-O', 'always-O', 'be-O', 'done-O', 'during-O', 'Bpd-B-Disease']
['Enhanced-O', 'isoproterenol-B-Chemical', ',-O', 'induced-O', 'cardiac-B-Disease', 'hypertrophy-I-Disease', 'in-O', 'transgenic-O', 'rats-O', 'with-O', 'low-O', 'brain-O', 'angiotensinogen-O', '.-O']
['We-O', 'have-O', 'previously-O', 'shown-O', 'that-O', 'a-O', 'permanent-O', 'deficiency-O', 'in-O', 'the-O', 'brain-O', 'renin-O', ',-O', 'angiotensin-B-Chemical', 'system-O', '(-O', 'RAS-O', ')-O', 'may-O', 'increase-O', 'the-O', 'sensitivity-O', 'of-O', 'the-O', 'baroreflex-O', 'control-O', 'of-O', 'heart-O', 'rate-O', '.-O']
['In-O', 'this-O', 'study-O', 'we-O', 'aimed-O', 'at-O', 'studying-O', 'the-O', 'involvement-O', 'of-O', 'the-O', 'brain-O', 'RAS-O', 'in-O', 'the-O', 'cardiac-O', 'reactivity-O', 'to-O', 'the-O', 'beta-O', ',-O', 'adrenoceptor-O', '(-O', 'beta-O', ',-O', 'AR-O', ')-O', 'agonist-O', 'isoproterenol-B-Chemical', '(-O', 'Iso-B-Chemical', ')-O', '.-O', 'Transgenic-O', 'rats-O', 'with-O', 'low-O', 'brain-O', 'angiotensinogen-B-Chemical', '(-O', 'TGR-O', ')-O', 'were-O', 'used-O', '.-O']
['In-O', 'isolated-O', 'hearts-O', ',-O', 'Iso-O', 'induced-O', 'a-O', 'significantly-O', 'greater-O', 'increase-O', 'in-O', 'left-O', 'ventricular-O', '(-O', 'LV-O', ')-O', 'pressure-O', 'and-O', 'maximal-O', 'contraction-O', '(+-O', 'dP-O', '/-O', 'dt-O', '(-O', 'max-O', '))-O', 'in-O', 'the-O', 'TGR-O', 'than-O', 'in-O', 'the-O', 'Sprague-O', ',-O', 'Dawley-O', '(-O', 'SD-O', ')-O', 'rats-O', '.-O']
['LV-O', 'hypertrophy-B-Disease', 'induced-O', 'by-O', 'Iso-B-Chemical', 'treatment-O', 'was-O', 'significantly-O', 'higher-O', 'in-O', 'TGR-O', 'than-O', 'in-O', 'SD-O', 'rats-O', '(-O', 'in-O', 'g-O', 'LV-O', 'wt-O', '/-O', '100-O', 'g-O', 'body-O', 'wt-O', ',-O', '0-O', '.-O']
['28-O', '+-O', '0-O', '.-O']
['004-O', 'vs-O', '.-O']
['0-O', '.-O']
['24-O', '+-O', '0-O', '.-O']
['004-O', ',-O', 'respectively-O', ')-O', '.-O', 'The-O', 'greater-O', 'LV-O', 'hypertrophy-O', 'in-O', 'TGR-O', 'rats-O', 'was-O', 'associated-O', 'with-O', 'more-O', 'pronounced-O', 'downregulation-O', 'of-O', 'beta-O', ',-O', 'AR-O', 'and-O', 'upregulation-O', 'of-O', 'LV-O', 'beta-O', ',-O', 'AR-O', 'kinase-O', ',-O', '1-O', 'mRNA-O', 'levels-O', 'compared-O', 'with-O', 'those-O', 'in-O', 'SD-O', 'rats-O', '.-O']
['The-O', 'decrease-O', 'in-O', 'the-O', 'heart-O', 'rate-O', '(-O', 'HR-O', ')-O', 'induced-O', 'by-O', 'the-O', 'beta-O', ',-O', 'AR-O', 'antagonist-O', 'metoprolol-B-Chemical', 'in-O', 'conscious-O', 'rats-O', 'was-O', 'significantly-O', 'attenuated-O', 'in-O', 'TGR-O', 'compared-O', 'with-O', 'SD-O', 'rats-O', '(-O', '9-O', '.-O']
['9-O', '+-O', '1-O', '.-O']
['7-O', '%-O', 'vs-O', '.--O', '18-O', '.-O']
['1-O', '+-O', '1-O', '.-O']
['5-O', '),-O', 'whereas-O', 'the-O', 'effect-O', 'of-O', 'parasympathetic-O', 'blockade-O', 'by-O', 'atropine-B-Chemical', 'on-O', 'HR-O', 'was-O', 'similar-O', 'in-O', 'both-O', 'strains-O', '.-O']
['These-O', 'results-O', 'indicate-O', 'that-O', 'TGR-O', 'are-O', 'more-O', 'sensitive-O', 'to-O', 'beta-O', ',-O', 'AR-O', 'agonist-O', ',-O', 'induced-O', 'cardiac-O', 'inotropic-O', 'response-O', 'and-O', 'hypertrophy-B-Disease']
['Drug-O', ',-O', 'induced-O', 'long-O', 'QT-O', 'syndrome-B-Disease', 'in-O', 'injection-O', 'drug-O', 'users-O', 'receiving-O', 'methadone-B-Chemical', ':-O', 'high-O', 'frequency-O', 'in-O', 'hospitalized-O', 'patients-O', 'and-O', 'risk-O', 'factors-O', '.-O']
['BACKGROUND-O', ':-O', 'Drug-O', ',-O', 'induced-O', 'long-O', 'QT-B-Disease', 'syndrome-I-Disease', 'is-O', 'a-O', 'serious-O', 'adverse-B-Disease', 'drug-I-Disease', 'reaction-O', '.-O']
['Methadone-B-Chemical', 'prolongs-O', 'the-O', 'QT-O', 'interval-O', 'in-O', 'vitro-O', 'in-O', 'a-O', 'dose-O', ',-O', 'dependent-O', 'manner-O', '.-O']
['In-O', 'the-O', 'inpatient-O', 'setting-O', ',-O', 'the-O', 'frequency-O', 'of-O', 'QT-O', 'interval-O', 'prolongation-O', 'with-O', 'methadone-B-Chemical', 'treatment-O', ',-O', 'its-O', 'dose-O', 'dependence-O', ',-O', 'and-O', 'the-O', 'importance-O', 'of-O', 'cofactors-O', 'such-O', 'as-O', 'drug-O', ',-O', 'drug-O', 'interactions-O', 'remain-O', 'unknown-O', '.-O']
['METHODS-O', ':-O', 'We-O', 'performed-O', 'a-O', 'systematic-O', ',-O', 'retrospective-O', 'study-O', 'comparing-O', 'active-O', 'or-O', 'former-O', 'intravenous-O', 'drug-O', 'users-O', 'receiving-O', 'methadone-B-Chemical', 'and-O', 'those-O', 'not-O', 'receiving-O', 'methadone-B-Chemical', 'among-O', 'all-O', 'patients-O', 'hospitalized-O', 'over-O', 'a-O', '5-O', ',-O', 'year-O', 'period-O', 'in-O', 'a-O', 'tertiary-O', 'care-O', 'hospital-O', '.-O']
['A-O', 'total-O', 'of-O', '167-O', 'patients-O', 'receiving-O', 'methadone-B-Chemical', 'fulfilled-O', 'the-O', 'inclusion-O', 'criteria-O', 'and-O', 'were-O', 'compared-O', 'with-O', 'a-O', 'control-O', 'group-O', 'of-O', '80-O', 'injection-O', 'drug-O', 'users-O', 'not-O', 'receiving-O', 'methadone-B-Chemical', '.-O']
['In-O', 'addition-O', 'to-O', 'methadone-B-Chemical', 'dose-O', ',-O', '15-O', 'demographic-O', ',-O', 'biological-O', ',-O', 'and-O', 'pharmacological-O', 'variables-O', 'were-O', 'considered-O', 'as-O', 'potential-O', 'risk-O', 'factors-O', 'for-O', 'QT-B-Disease', 'prolongation-I-Disease', '.-O']
['RESULTS-O', ':-O', 'Among-O', '167-O', 'methadone-B-Chemical', 'maintenance-O', 'patients-O', ',-O', 'the-O', 'prevalence-O', 'of-O', 'QTc-B-Disease', 'prolongation-I-Disease', 'to-O', '0-O', '.-O']
['50-O', 'second-O', '((-O', '1-O', '/-O', '2-O', '))-O', 'or-O', 'longer-O', 'was-O', '16-O', '.-O']
['2-O', '%-O', 'compared-O', 'with-O', '0-O', '%-O', 'in-O', '80-O', 'control-O', 'subjects-O', '.-O']
['Six-O', 'patients-O', '(-O', '3-O', '.-O']
['6-O', ')-O', 'in-O', 'the-O', 'methadone-B-Chemical', 'group-O', 'presented-O', 'torsades-B-Disease', 'de-I-Disease', 'pointes-I-Disease', '.-O']
['QTc-O', 'length-O', 'was-O', 'weakly-O', 'but-O', 'significantly-O', 'associated-O', 'with-O', 'methadone-B-Chemical', 'daily-O', 'dose-O', '(-O', 'Spearman-O', 'rank-O', 'correlation-O', 'coefficient-O', ',-O', '0-O', '.-O']
['20-O', ';-O', 'P-O', '<.-O', '01-O', ').-O', 'Multivariate-O', 'regression-O', 'analysis-O', 'allowed-O', 'attribution-O', 'of-O', '31-O', '.-O']
['8-O', '%-O', 'of-O', 'QTc-O', 'variability-O', 'to-O', 'methadone-B-Chemical', 'dose-O', ',-O', 'cytochrome-O', 'P-O', '450-O', '3A4-O', 'drug-O', ',-O', 'drug-O', 'interactions-O', ',-O', 'hypokalemia-B-Disease', ',-O', 'and-O', 'altered-O', 'liver-O', 'function-O', '.-O']
['CONCLUSIONS-O', ':-O', 'QT-O', 'interval-O', 'prolongation-O', 'in-O', 'methadone-B-Chemical', 'maintenance-O', 'patients-O', 'hospitalized-O', 'in-O', 'a-O', 'tertiary-O', 'care-O', 'center-O', 'is-O', 'a-O', 'frequent-O', 'finding-O', '.-O']
['Methadone-B-Chemical', 'dose-O', ',-O', 'presence-O', 'of-O', 'cytochrome-O', 'P-O', '450-O', '3A4-O', 'inhibitors-O', ',-O', 'potassium-B-Chemical', 'level-O', ',-O', 'and-O', 'liver-O', 'function-O', 'contribute-O', 'to-O', 'QT-O', 'prolongation-B-Disease', '.-O']
['Long-O', 'QT-O', 'syndrome-B-Disease', 'can-O', 'occur-O', 'with-O', 'low-O', 'doses-O', 'of-O', 'methadone-B-Chemical']
['Mechanisms-O', 'of-O', 'hypertension-B-Disease', 'induced-O', 'by-O', 'nitric-B-Chemical', 'oxide-I-Chemical', '(-O', 'NO-B-Chemical', ')-O', 'deficiency-O', ':-O', 'focus-O', 'on-O', 'venous-O', 'function-O', '.-O']
['Loss-O', 'of-O', 'endothelial-O', 'cell-O', ',-O', 'derived-O', 'nitric-B-Chemical', 'oxide-I-Chemical', '(-O', 'NO-B-Chemical', ')-O', 'in-O', 'hypertension-B-Disease', 'is-O', 'a-O', 'hallmark-O', 'of-O', 'arterial-O', 'dysfunction-O', '.-O']
['Experimental-O', 'hypertension-B-Disease', 'created-O', 'by-O', 'the-O', 'removal-O', 'of-O', 'NO-B-Chemical', ',-O', 'however-O', ',-O', 'involves-O', 'mechanisms-O', 'in-O', 'addition-O', 'to-O', 'decreased-O', 'arterial-O', 'vasodilator-O', 'activity-O', '.-O']
['These-O', 'include-O', 'augmented-O', 'endothelin-B-Chemical', ',-O', '1-O', '(-O', 'ET-O', ',-O', '1-O', ')-O', 'release-O', ',-O', 'increased-O', 'sympathetic-O', 'nervous-O', 'system-O', 'activity-O', ',-O', 'and-O', 'elevated-O', 'tissue-O', 'oxidative-O', 'stress-O', '.-O']
['We-O', 'hypothesized-O', 'that-O', 'increased-O', 'venous-O', 'smooth-O', 'muscle-O', '(-O', 'venomotor-O', ')-O', 'tone-O', 'plays-O', 'a-O', 'role-O', 'in-O', 'Nomega-nitro-L-arginine-B-Chemical', '(-O', 'LNNA-B-Chemical', ')-O', 'hypertension-B-Disease', 'through-O', 'these-O', 'mechanisms-O', '.-O']
['Rats-O', 'were-O', 'treated-O', 'with-O', 'the-O', 'NO-B-Chemical', 'synthase-O', 'inhibitor-O', 'LNNA-B-Chemical', '(-O', '0-O', '.-O']
['5-O', 'g-O', '/-O', 'L-O', 'in-O', 'drinking-O', 'water-O', ')-O', 'for-O', '2-O', 'weeks-O', '.-O']
['Mean-O', 'arterial-O', 'pressure-O', 'of-O', 'conscious-O', 'rats-O', 'was-O', '119-O', '+-O', '2-O', 'mm-O', 'Hg-O', 'in-O', 'control-O', 'and-O', '194-O', '+-O', '5-O', 'mm-O', 'Hg-O', 'in-O', 'LNNA-B-Chemical', 'rats-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'Carotid-O', 'arteries-O', 'and-O', 'vena-O', 'cava-O', 'were-O', 'removed-O', 'for-O', 'measurement-O', 'of-O', 'isometric-O', 'contraction-O', '.-O']
['Maximal-O', 'contraction-O', 'to-O', 'norepinephrine-B-Chemical', 'was-O', 'modestly-O', 'reduced-O', 'in-O', 'arteries-O', 'from-O', 'LNNA-B-Chemical', 'compared-O', 'with-O', 'control-O', 'rats-O', 'whereas-O', 'the-O', 'maximum-O', 'contraction-O', 'to-O', 'ET-B-Chemical', ',-O', '1-O', 'was-O', 'significantly-O', 'reduced-O', '(-O', '54-O', '%-O', 'control-O', ').-O', 'Maximum-O', 'contraction-O', 'of-O', 'vena-O', 'cava-O', 'to-O', 'norepinephrine-B-Chemical', '(-O', '37-O', '%-O', 'control-O', ')', 'also-O', 'was-O', 'reduced-O', 'but-O', 'no-O', 'change-O', 'in-O', 'response-O', 'to-O', 'ET-B-Chemical', ',-O', '1-O', 'was-O', 'observed-O', '.-O']
['Mean-O', 'circulatory-O', 'filling-O', 'pressure-O', ',-O', 'an-O', 'in-O', 'vivo-O', 'measure-O', 'of-O', 'venomotor-O', 'tone-O', ',-O', 'was-O', 'not-O', 'elevated-O', 'in-O', 'LNNA-B-Chemical', 'hypertension-B-Disease', 'at-O', '1-O', 'or-O', '2-O', 'weeks-O', 'after-O', 'LNNA-B-Chemical', '.-O']
['The-O', 'superoxide-O', 'scavenger-O', 'tempol-B-Chemical', '(-O', '30-O', '-O', '100-O', '-O', 'and-O', '300-O', 'micromol-O', 'kg-O', '(-O', '1-O', ')-O', 'IV-O', ')-O', 'did-O', 'not-O', 'change-O', 'arterial-O', 'pressure-O', 'in-O', 'control-O', 'rats-O', 'but-O', 'caused-O', 'a-O', 'dose-O', '-O', 'dependent-O', 'decrease-O', 'in-O', 'LNNA-O', 'rats-O', '(-O', '18-O', '+-O', '8-O', '-O', '26-O', '+-O', '15-O', '-O', 'and-O', '-O', '54-O', '+-O', '11-O', 'mm-O', 'Hg-O', ').-O', 'Similarly-O', '-O', 'ganglionic-O', 'blockade-O', 'with-O', 'hexamethonium-B-Chemical', 'caused-O', 'a-O', 'significantly-O', 'greater-O', 'fall-O', 'in-O', 'LNNA-O', 'hypertensive-O', 'rats-O', '(-O', '76-O', '+-O', '9-O', 'mm-O', 'Hg-O', ')-O', 'compared-O', 'with-O', 'control-O', 'rats-O', '(-O', '35-O', '+-O', '10-O', 'mm-O', 'Hg-O', ').-O', 'Carotid-O', 'arteries-O', '-O', 'vena-O', 'cava-O', '-O', 'and-O', 'sympathetic-O', 'ganglia-O', 'from-O', 'LNNA-O', 'rats-O', 'had-O', 'higher-O', 'basal-O', 'levels-O', 'of-O', 'superoxide-O', 'compared-O', 'with-O', 'those-O', 'from-O', 'control-O', 'rats-O', '.-O']
['These-O', 'data-O', 'suggest-O', 'that-O', 'while-O', 'NO-B-Chemical', 'deficiency-O', 'increases-O', 'oxidative-O', 'stress-O', 'and-O', 'sympathetic-O', 'activity-O', 'in-O', 'both-O', 'arterial-O', 'and-O', 'venous-O', 'vessels-O', ',-O', 'the-O', 'impact-O', 'on-O', 'veins-O', 'does-O', 'not-O', 'make-O', 'a-O', 'major-O', 'contribution-O', 'to-O', 'this-O', 'form-O', 'of-O', 'hypertension-B-Disease']
['Association-O', 'of-O', 'DRD2-O', 'polymorphisms-O', 'and-O', 'chlorpromazine-B-Chemical', ',-O', 'induced-O', 'extrapyramidal-B-Disease', 'syndrome-I-Disease', 'in-O', 'Chinese-O', 'schizophrenic-B-Disease', 'patients-O', '.-O']
['AIM-O', ':-O', 'Extrapyramidal-O', 'syndrome-O', '(-O', 'EPS-O', ')-O', 'is-O', 'most-O', 'commonly-O', 'affected-O', 'by-O', 'typical-O', 'antipsychotic-O', 'drugs-O', 'that-O', 'have-O', 'a-O', 'high-O', 'affinity-O', 'with-O', 'the-O', 'D2-O', 'receptor-O', '.-O']
['Recently-O', ',-O', 'many-O', 'research-O', 'groups-O', 'have-O', 'reported-O', 'on-O', 'the-O', 'positive-O', 'relationship-O', 'between-O', 'the-O', 'genetic-O', 'variations-O', 'in-O', 'the-O', 'DRD2-O', 'gene-O', 'and-O', 'the-O', 'therapeutic-O', 'response-O', 'in-O', 'schizophrenia-B-Disease', 'patients-O', 'as-O', 'a-O', 'result-O', 'of-O', 'the-O', 'role-O', 'of-O', 'variations-O', 'in-O', 'the-O', 'receptor-O', 'in-O', 'modulating-O', 'receptor-O', 'expression-O', '.-O']
['In-O', 'this-O', 'study-O', ',-O', 'we-O', 'evaluate-O', 'the-O', 'role-O', 'DRD2-O', 'plays-O', 'in-O', 'chlorpromazine-B-Chemical', ',-O', 'induced-O', 'EPS-B-Disease', 'in-O', 'schizophrenic-B-Disease', 'patients-O', '.-O']
['METHODS-O', ':-O', 'We-O', 'identified-O', 'seven-O', 'SNP-B-Chemical', '(-O', 'single-O', 'nucleotide-O', 'polymorphism-O', ')(-O', '141Cins-O', '>-O', 'del-O', ',-O', 'TaqIB-O', ',-O', 'TaqID-O', ',-O', 'Ser311Cys-O', ',-O', 'rs6275-O', ',-O', 'rs6277-O', 'and-O', 'TaqIA-O', ')-O', 'in-O', 'the-O', 'DRD2-B-Chemical', 'gene-O', 'in-O', '146-O', 'schizophrenic-B-Disease', 'inpatients-O', '(-O', '59-O', 'with-O', 'EPS-B-Disease', 'and-O', '87-O', 'without-O', 'EPS-B-Disease', ')-O', 'according-O', 'to-O', 'the-O', 'Simpson-O', ',-O', 'Angus-O', 'Scale-O', ')-O', 'treated-O', 'with-O', 'chlorpromazine-B-Chemical', 'after-O', '8-O', 'weeks-O', '.-O']
['The-O', 'alleles-O', 'of-O', 'all-O', 'loci-O', 'were-O', 'determined-O', 'by-O', 'PCR-O', '(-O', 'polymerase-O', 'chain-O', 'reaction-O', ').-O', 'RESULTS-O', ':-O', 'Polymorphisms-O', 'TaqID-O', ',-O', 'Ser311Cys-O', 'and-O', 'rs6277-O', 'were-O', 'not-O', 'polymorphic-O', 'in-O', 'the-O', 'population-O', 'recruited-O', 'in-O', 'the-O', 'present-O', 'study-O', '.-O']
['No-O', 'statistical-O', 'significance-O', 'was-O', 'found-O', 'in-O', 'the-O', 'allele-O', 'distribution-O', 'of-O', ',-O', '141Cins-B-Chemical', '>-O', 'del-O', ',-O', 'TaqIB-B-Chemical', ',-O', 'rs6275-B-Chemical', 'and-O', 'TaqIA-B-Chemical', 'or-O', 'in-O', 'the-O', 'estimated-O', 'haplotypes-O', '(-O', 'constituted-O', 'by-O', 'TaqIB-B-Chemical', ',-O', 'rs6275-B-Chemical', 'and-O', 'TaqIA-B-Chemical', ')-O', 'in-O', 'linkage-O', 'disequilibrium-O', 'between-O', 'the-O', 'two-O', 'groups-O', '.-O']
['CONCLUSION-O', ':-O', 'Our-O', 'results-O', 'did-O', 'not-O', 'lend-O', 'strong-O', 'support-O', 'to-O', 'the-O', 'view-O', 'that-O', 'the-O', 'genetic-O', 'variation-O', 'of-O', 'the-O', 'DRD2-O', 'gene-O', 'plays-O', 'a-O', 'major-O', 'role-O', 'in-O', 'the-O', 'individually-O', 'variable-O', 'adverse-O', 'effect-O', 'induced-O', 'by-O', 'chlorpromazine-B-Chemical', ',-O', 'at-O', 'least-O', 'in-O', 'Chinese-O', 'patients-O', 'with-O', 'schizophrenia-B-Disease', '.-O']
['Our-O', 'results-O', 'confirmed-O', 'a-O', 'previous-O', 'study-O', 'on-O', 'the-O', 'relationship-O', 'between-O', 'DRD2-B-Chemical', 'and-O', 'EPS-B-Disease', '.-O']
['Physical-O', 'training-O', 'decreases-O', 'susceptibility-O', 'to-O', 'subsequent-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', 'in-O', 'the-O', 'rat-O', '.-O']
['Regular-O', 'motor-O', 'activity-O', 'has-O', 'many-O', 'benefits-O', 'for-O', 'mental-O', 'and-O', 'physical-O', 'condition-O', 'but-O', 'its-O', 'implications-O', 'for-O', 'epilepsy-B-Disease', 'are-O', 'still-O', 'controversial-O', '.-O']
['In-O', 'order-O', 'to-O', 'elucidate-O', 'this-O', 'problem-O', ',-O', 'we-O', 'have-O', 'studied-O', 'the-O', 'effect-O', 'of-O', 'long-O', ',-O', 'term-O', 'physical-O', 'activity-O', 'on-O', 'susceptibility-O', 'to-O', 'subsequent-O', 'seizures-B-Disease', '.-O']
['Male-O', 'Wistar-O', 'rats-O', 'were-O', 'subjected-O', 'to-O', 'repeated-O', 'training-O', 'sessions-O', 'in-O', 'a-O', 'treadmill-O', 'and-O', 'swimming-O', 'pool-O', '.-O']
['Thereafter-O', ',-O', 'seizures-B-Disease', 'were-O', 'induced-O', 'by-O', 'pilocarpine-B-Chemical', 'injections-O', 'in-O', 'trained-O', 'and-O', 'non-O', ',-O', 'trained-O', 'control-O', 'groups-O', '.-O']
['During-O', 'the-O', 'acute-O', 'period-O', 'of-O', 'status-O', 'epilepticus-B-Disease', ',-O', 'we-O', 'measured-O', ':-O', '(1)-O', 'the-O', 'latency-O', 'of-O', 'the-O', 'first-O', 'motor-O', 'sign-O', '(2)-O', 'the-O', 'intensity-O', 'of-O', 'seizures-B-Disease', '(3)-O', 'the-O', 'time-O', 'when-O', 'it-O', 'occurred-O', 'within-O', 'the-O', '6-O', ',-O', 'h-O', 'observation-O', 'period-O', ',-O', 'and-O', '(4)-O', 'the-O', 'time-O', 'when-O', 'the-O', 'acute-O', 'period-O', 'ended-O', '.-O']
['All-O', 'these-O', 'behavioral-O', 'parameters-O', 'showed-O', 'statistically-O', 'significant-O', 'changes-O', 'suggesting-O', 'that-O', 'regular-O', 'physical-O', 'exercises-O', 'decrease-O', 'susceptibility-O', 'to-O', 'subsequently-O', 'induced-O', 'seizures-B-Disease', 'and-O', 'ameliorate-O', 'the-O', 'course-O', 'of-O', 'experimentally-O', 'induced-O', 'status-B-Disease', 'epilepticus-I-Disease']
['Tonic-O', 'dopaminergic-O', 'stimulation-O', 'impairs-O', 'associative-O', 'learning-O', 'in-O', 'healthy-O', 'subjects-O', '.-O']
['Endogenous-O', 'dopamine-B-Chemical', 'plays-O', 'a-O', 'central-O', 'role-O', 'in-O', 'salience-O', 'coding-O', 'during-O', 'associative-O', 'learning-O', '.-O']
['Administration-O', 'of-O', 'the-O', 'dopamine-B-Chemical', 'precursor-O', 'levodopa-B-Chemical', 'enhances-O', 'learning-O', 'in-O', 'healthy-O', 'subjects-O', 'and-O', 'stroke-B-Disease', 'patients-O', '.-O']
['Because-O', 'levodopa-B-Chemical', 'increases-O', 'both-O', 'phasic-O', 'and-O', 'tonic-O', 'dopaminergic-O', 'neurotransmission-O', ',-O', 'the-O', 'critical-O', 'mechanism-O', 'mediating-O', 'the-O', 'enhancement-O', 'of-O', 'learning-O', 'is-O', 'unresolved-O', '.-O']
['We-O', 'here-O', 'probed-O', 'how-O', 'selective-O', 'tonic-O', 'dopaminergic-O', 'stimulation-O', 'affects-O', 'associative-O', 'learning-O', '.-O']
['Forty-O', 'healthy-O', 'subjects-O', 'were-O', 'trained-O', 'in-O', 'a-O', 'novel-O', 'vocabulary-O', 'of-O', '45-O', 'concrete-O', 'nouns-O', 'over-O', 'the-O', 'course-O', 'of-O', '5-O', 'consecutive-O', 'training-O', 'days-O', 'in-O', 'a-O', 'prospective-O', ',-O', 'randomized-O', ',-O', 'double-O', ',-O', 'blind-O', ',-O', 'placebo-O', ',-O', 'controlled-O', 'design-O', '.-O']
['Subjects-O', 'received-O', 'the-O', 'tonically-O', 'stimulating-O', 'dopamine-B-Chemical', ',-O', 'receptor-O', 'agonist-O', 'pergolide-B-Chemical', '(-O', '0-O', '.-O']
['1-O', 'mg-O', ')-O', 'vs-O', 'placebo-O', '120-O', 'min-O', 'before-O', 'training-O', 'on-O', 'each-O', 'training-O', 'day-O', '.-O']
['The-O', 'dopamine-B-Chemical', 'agonist-O', 'significantly-O', 'impaired-O', 'novel-O', 'word-O', 'learning-O', 'compared-O', 'to-O', 'placebo-O', '.-O']
['This-O', 'learning-O', 'decrement-O', 'persisted-O', 'up-O', 'to-O', 'the-O', 'last-O', 'follow-O', ',-O', 'up-O', '4-O', 'weeks-O', 'post-O', ',-O', 'training-O', '.-O']
['Subjects-O', 'treated-O', 'with-O', 'pergolide-B-Chemical', 'also-O', 'showed-O', 'restricted-O', 'emotional-O', 'responses-O', 'compared-O', 'to-O', 'the-O', 'PLACEBO-O', 'group-O', '.-O']
['The-O', 'extent-O', 'of-O', 'x-O', 'flattened-O', 'x-O', 'affect-O', 'with-O', 'pergolide-B-Chemical', 'was-O', 'related-O', 'to-O', 'the-O', 'degree-O', 'of-O', 'learning-O', 'inhibition-O', '.-O']
['These-O', 'findings-O', 'suggest-O', 'that-O', 'tonic-O', 'occupation-O', 'of-O', 'dopamine-B-Chemical', 'receptors-O', 'impairs-O', 'learning-O', 'by-O', 'competition-O', 'with-O', 'phasic-O', 'dopamine-B-Chemical', 'signals-O', '.-O']
['Thus-O', ',-O', 'phasic-O', 'signaling-O', 'seems-O', 'to-O', 'be-O', 'the-O', 'critical-O', 'mechanism-O', 'by-O', 'which-O', 'dopamine-B-Chemical', 'enhances-O', 'associative-O', 'learning-O', 'in-O', 'healthy-O', 'subjects-O', 'and-O', 'stroke-B-Disease']
['Minocycline-B-Chemical', ',-O', 'induced-O', 'vasculitis-B-Disease', 'fulfilling-O', 'the-O', 'criteria-O', 'of-O', 'polyarteritis-B-Disease', 'nodosa-B-Disease', '.-O']
['A-O', '47-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'who-O', 'had-O', 'been-O', 'taking-O', 'minocycline-B-Chemical', 'for-O', 'palmoplantar-O', 'pustulosis-B-Disease', 'developed-O', 'fever-B-Disease', ',-O', 'myalgias-B-Disease', ',-O', 'polyneuropathy-B-Disease', ',-O', 'and-O', 'testicular-O', 'pain-B-Disease', ',-O', 'with-O', 'elevated-O', 'C-O', ',-O', 'reactive-O', 'protein-O', '(-O', 'CRP-B-Chemical', ').-O', 'Neither-O', 'myeloperoxidase-B-Chemical', ',-O', 'nor-O', 'proteinase-B-Chemical', ',-O', '3-O', ',-O', 'antineutrophil-O', 'cytoplasmic-O', 'antibody-O', 'was-O', 'positive-O', '.-O']
['These-O', 'manifestations-O', 'met-O', 'the-O', 'American-O', 'College-O', 'of-O', 'Rheumatology-O', '1990-O', 'criteria-O', 'for-O', 'the-O', 'classification-O', 'of-O', 'polyarteritis-B-Disease', 'nodosa-I-Disease', '.-O']
['Stopping-O', 'minocycline-B-Chemical', 'led-O', 'to-O', 'amelioration-O', 'of-O', 'symptoms-O', 'and-O', 'normalization-O', 'of-O', 'CRP-B-Chemical', 'level-O', '.-O']
['To-O', 'our-O', 'knowledge-O', ',-O', 'this-O', 'is-O', 'the-O', 'second-O', 'case-O', 'of-O', 'minocycline-B-Chemical', ',-O', 'induced-O', 'vasculitis-B-Disease', 'satisfying-O', 'the-O', 'criteria-O', '.-O']
['Differential-O', 'diagnosis-O', 'for-O', 'drug-O', ',-O', 'induced-O', 'disease-B-Disease', 'is-O', 'invaluable-O', 'even-O', 'for-O', 'patients-O', 'with-O', 'classical-O', 'polyarteritis-B-Disease', 'nodosa-I-Disease']
['Intramuscular-O', 'hepatitis-B-Chemical', 'B-I-Chemical', 'immune-O', 'globulin-O', 'combined-O', 'with-O', 'lamivudine-B-Chemical', 'in-O', 'prevention-O', 'of-O', 'hepatitis-B-Chemical', 'B-I-Chemical', 'recurrence-O', 'after-O', 'liver-O', 'transplantation-O', '.-O']
['BACKGROUND-O', ':-O', 'Combined-O', 'hepatitis-B-Chemical', 'B-I-Chemical', 'immune-O', 'globulin-O', '(-O', 'HBIg-B-Chemical', ')-O', 'and-O', 'lamivudine-B-Chemical', 'in-O', 'prophylaxis-O', 'of-O', 'the-O', 'recurrence-O', 'of-O', 'hepatitis-B-Chemical', 'B-I-Chemical', 'after-O', 'liver-O', 'transplantation-O', 'has-O', 'significantly-O', 'improved-O', 'the-O', 'survival-O', 'of-O', 'HBsAg-B-Chemical', 'positive-O', 'patients-O', '.-O']
['This-O', 'study-O', 'was-O', 'undertaken-O', 'to-O', 'evaluate-O', 'the-O', 'outcomes-O', 'of-O', 'liver-O', 'transplantation-O', 'for-O', 'patients-O', 'with-O', 'hepatitis-B-Disease', 'B-I-Disease', 'virus-O', '(-O', 'HBV-O', ')-O', '.', 'METHODS-O', ':-O', 'A-O', 'retrospective-O', 'chart-O', 'analysis-O', 'and-O', 'a-O', 'review-O', 'of-O', 'the-O', 'organ-O', 'transplant-O', 'database-O', 'identified-O', '51-O', 'patients-O', '(-O', '43-O', 'men-O', 'and-O', '8-O', 'women-O', ')-O', 'transplanted-O', 'for-O', 'benign-O', 'HBV-O', 'related-O', 'cirrhotic-O', 'diseases-O', 'between-O', 'June-O', '2002-O', 'and-O', 'December-O', '2004-O', 'who-O', 'had-O', 'survived-O', 'more-O', 'than-O', '3-O', 'months-O', '.-O']
['HBIg-B-Chemical', 'was-O', 'administered-O', 'intravenously-O', 'during-O', 'the-O', 'first-O', 'week-O', 'and-O', 'intramuscularly-O', 'thereafter-O', '.-O']
['RESULTS-O', ':-O', 'At-O', 'a-O', 'median-O', 'follow-O', ',-O', 'up-O', 'of-O', '14-O', '.-O']
['1-O', 'months-O', ',-O', 'the-O', 'overall-O', 'recurrence-O', 'rate-O', 'in-O', 'the-O', '51-O', 'patients-O', 'was-O', '3-O', '.-O']
['9-O', '(-O', '2-O', '/-O', '51-O', ').-O', 'The-O', 'overall-O', 'patient-O', 'survival-O', 'was-O', '88-O', '.-O']
['3-O', ',-O', 'and-O', '82-O', '.-O']
['4-O', '%-O', 'after-O', '1-O', 'and-O', '2-O', 'years-O', ',-O', 'respectively-O', '.-O']
['A-O', 'daily-O', 'oral-O', 'dose-O', 'of-O', '100-O', 'mg-O', 'lamivudine-B-Chemical', 'for-O', '2-O', 'weeks-O', 'before-O', 'transplantation-O', 'for-O', '10-O', 'patients-O', 'enabled-O', '57-O', '.-O']
['1-O', '(-O', '4-O', '/-O', '7-O', ')-O', 'and-O', '62-O', '.-O']
['5-O', '(-O', '5-O', '/-O', '8-O', ')-O', 'of-O', 'HBV-O', ',-O', 'DNA-O', 'and-O', 'HBeAg-B-Chemical', 'positive-O', 'patients-O', 'respectively-O', 'to-O', 'convert-O', 'to-O', 'be-O', 'negative-O', '.-O']
['Intramuscular-O', 'HBIg-B-Chemical', 'was-O', 'well-O', 'tolerated-O', 'in-O', 'all-O', 'patients-O', '.-O']
['CONCLUSION-O', ':-O', 'Lamivudine-B-Chemical']
['Anticonvulsant-O', 'effect-O', 'of-O', 'eslicarbazepine-B-Chemical', 'acetate-I-Chemical', '(-O', 'BIA-B-Chemical', '2-093-B-Chemical', ')-O', 'on-O', 'seizures-B-Disease', 'induced-O', 'by-O', 'microperfusion-O', 'of-O', 'picrotoxin-B-Chemical', 'in-O', 'the-O', 'hippocampus-O', 'of-O', 'freely-O', 'moving-O', 'rats-O', '.-O']
['Eslicarbazepine-B-Chemical', 'acetate-I-Chemical', '(-O', 'BIA-B-Chemical', '2-093-O', ',', 'S-(-)-10-acetoxy-10,11-dihydro-5H-dibenzo/b,f/azepine-5-carboxamide-I-Chemical', ')-O', 'is-O', 'a-O', 'novel-O', 'antiepileptic-O', 'drug-O', ',-O', 'now-O', 'in-O', 'Phase-O', 'III-O', 'clinical-O', 'trials-O', ',-O', 'designed-O', 'with-O', 'the-O', 'aim-O', 'of-O', 'improving-O', 'efficacy-O', 'and-O', 'safety-O', 'in-O', 'comparison-O', 'with-O', 'the-O', 'structurally-O', 'related-O', 'drugs-O', 'carbamazepine-B-Chemical', '(-O', 'CBZ-B-Chemical', ')-O', 'and-O', 'oxcarbazepine-B-Chemical', '(-O', 'OXC-B-Chemical', ')-O', '.-O', 'We-O', 'have-O', 'studied-O', 'the-O', 'effects-O', 'of-O', 'oral-O', 'treatment-O', 'with-O', 'eslicarbazepine-B-Chemical', 'acetate-I-Chemical', 'on-O', 'a-O', 'whole-O', ',', 'animal-O', 'model-O', 'in-O', 'which-O', 'partial-O', 'seizures-B-Disease', 'can-O', 'be-O', 'elicited-O', 'repeatedly-O', 'on-O', 'different-O', 'days-O', 'without-O', 'changes-O', 'in-O', 'threshold-O', 'or-O', 'seizure-O', 'patterns-O', '.-O']
['In-O', 'the-O', 'animals-O', 'treated-O', 'with-O', 'threshold-O', 'doses-O', 'of-O', 'picrotoxin-B-Chemical', ',-O', 'the-O', 'average-O', 'number-O', 'of-O', 'seizures-B-Disease', 'was-O', '2-O', '.-O']
['3-O', '+-O', '1-O', '.-O']
['2-O', ',-O', 'and-O', 'average-O', 'seizure-B-Disease', 'duration-O', 'was-O', '39-O', '.-O']
['5-O', '+-O', '8-O', '.-O']
['4s-O', '.-O']
['Pre-O', ',-O', 'treatment-O', 'with-O', 'a-O', 'dose-O', 'of-O', '30-O', 'mg-O', '/-O', 'kg-O', '2h-O', 'before-O', 'picrotoxin-B-Chemical', 'microperfusion-O', 'prevented-O', 'seizures-B-Disease', 'in-O', 'the-O', '75-O', '%-O', 'of-O', 'the-O', 'rats-O', '.-O']
['Lower-O', 'doses-O', '(-O', '3-O', 'and-O', '10mg-O', '/-O', 'kg-O', ')-O', 'did-O', 'not-O', 'suppress-O', 'seizures-B-Disease', ',-O', 'however-O', ',-O', 'after-O', 'administration-O', 'of-O', '10mg-O', '/-O', 'kg-O', ',-O', 'significant-O', 'reductions-O', 'in-O', 'seizures-B-Disease', 'duration-O', '(-O', '24-O', '.-O']
['3-O', '+-O', '6-O', '.-O']
['8s-O', ')-O', 'and-O', 'seizure-B-Disease', 'number-O', '(-O', '1-O', '.-O']
['6-O', '+-O', '0-O', '.-O']
['34-O', ')-O', 'were-O', 'found-O', '.-O']
['No-O', 'adverse-O', 'effects-O', 'of-O', 'eslicarbazepine-B-Chemical', 'acetate-I-Chemical']
['Acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'associated-O', 'with-O', 'prolonged-O', 'intake-O', 'of-O', 'slimming-O', 'pills-O', 'containing-O', 'anthraquinones-B-Chemical', '.-O']
['Chinese-O', 'herbal-O', 'medicine-O', 'preparations-O', 'are-O', 'widely-O', 'available-O', 'and-O', 'often-O', 'regarded-O', 'by-O', 'the-O', 'public-O', 'as-O', 'natural-O', 'and-O', 'safe-O', 'remedies-O', 'for-O', 'a-O', 'variety-O', 'of-O', 'medical-O', 'conditions-O', '.-O']
['Nephropathy-B-Disease', 'caused-O', 'by-O', 'Chinese-O', 'herbs-O', 'has-O', 'previously-O', 'been-O', 'reported-O', ',-O', 'usually-O', 'involving-O', 'the-O', 'use-O', 'of-O', 'aristolochic-B-Chemical', 'acids-B-Chemical', '.-O']
['We-O', 'report-O', 'a-O', '23-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'who-O', 'developed-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'following-O', 'prolonged-O', 'use-O', 'of-O', 'a-O', 'proprietary-O', 'Chinese-O', 'herbal-O', 'slimming-O', 'pill-O', 'that-O', 'contained-O', 'anthraquinone-B-Chemical', 'derivatives-O', ',-O', 'extracted-O', 'from-O', 'Rhizoma-O', 'Rhei-O', '(-O', 'rhubarb-O', ')-O', '.-O', 'The-O', 'renal-O', 'injury-O', 'was-O', 'probably-O', 'aggravated-O', 'by-O', 'the-O', 'concomitant-O', 'intake-O', 'of-O', 'a-O', 'non-O', ',-O', 'steroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'drug-O', ',-O', 'diclofenac-B-Chemical', '.-O']
['Renal-O', 'pathology-O', 'was-O', 'that-O', 'of-O', 'hypocellular-O', 'interstitial-B-Disease', 'fibrosis-B-Disease', '.-O']
['Spontaneous-O', 'renal-O', 'recovery-O', 'occurred-O', 'upon-O', 'cessation-O', 'of-O', 'the-O', 'slimming-O', 'pills-O', ',-O', 'but-O', 'mild-O', 'interstitial-O', 'fibrosis-B-Disease', 'and-O', 'tubular-O', 'atrophy-B-Disease', 'was-O', 'still-O', 'evident-O', 'histologically-O', '4-O', 'months-O', 'later-O', '.-O']
['Although-O', 'a-O', 'causal-O', 'relationship-O', 'between-O', 'the-O', 'use-O', 'of-O', 'an-O', 'anthraquinone-B-Chemical', ',-O', 'containing-O', 'herbal-O', 'agent-O', 'and-O', 'renal-B-Disease', 'injury-I-Disease', 'remains-O', 'to-O', 'be-O', 'proven-O', ',-O', 'phytotherapy-O', ',-O', 'associated-O', 'interstitial-B-Disease', 'nephropathy-I-Disease', 'should-O', 'be-O', 'considered-O', 'in-O', 'patients-O', 'who-O', 'present-O', 'with-O', 'unexplained-O', 'renal-B-Disease', 'failure-I-Disease']
['Chloroacetaldehyde-B-Chemical', 'as-O', 'a-O', 'sulfhydryl-O', 'reagent-O', ':-O', 'the-O', 'role-O', 'of-O', 'critical-O', 'thiol-O', 'groups-O', 'in-O', 'ifosfamide-B-Chemical', 'nephropathy-B-Disease', '.-O']
['Chloroacetaldehyde-B-Chemical', '(-O', 'CAA-B-Chemical', ')-O', 'is-O', 'a-O', 'metabolite-O', 'of-O', 'the-O', 'alkylating-B-Chemical', 'agent-O', 'ifosfamide-B-Chemical', '(-O', 'IFO-B-Chemical', ')-O', 'and-O', 'putatively-O', 'responsible-O', 'for-O', 'renal-B-Disease', 'damage-I-Disease', 'following-O', 'anti-O', 'tumor-O', 'therapy-O', 'with-O', 'IFO-B-Chemical', '.-O']
['Depletion-O', 'of-O', 'sulfhydryl-O', '(-O', 'SH-O', ')-O', 'groups-O', 'has-O', 'been-O', 'reported-O', 'from-O', 'cell-O', 'culture-O', ',-O', 'animal-O', 'and-O', 'clinical-O', 'studies-O', '.-O']
['In-O', 'this-O', 'work-O', 'the-O', 'effect-O', 'of-O', 'CAA-B-Chemical', 'on-O', 'human-O', 'proximal-O', 'tubule-O', 'cells-O', 'in-O', 'primary-O', 'culture-O', '(-O', 'hRPTEC-O', ')-O', 'was-O', 'investigated-O', '.-O']
['Toxicity-B-Disease', 'of-O', 'CAA-B-Chemical', 'was-O', 'determined-O', 'by-O', 'protein-O', 'content-O', ',-O', 'cell-O', 'number-O', ',-O', 'LDH-O', 'release-O', ',-O', 'trypan-O', 'blue-O', 'exclusion-O', 'assay-O', 'and-O', 'caspase-O', ',', '3-O', 'activity-O', '.-O']
['Free-O', 'thiols-O', 'were-O', 'measured-O', 'by-O', 'the-O', 'method-O', 'of-O', 'Ellman-O', '.-O']
['CAA-B-Chemical', 'reduced-O', 'hRPTEC-O', 'cell-O', 'number-O', 'and-O', 'protein-O', ',-O', 'induced-O', 'a-O', 'loss-O', 'in-O', 'free-O', 'intracellular-O', 'thiols-O', 'and-O', 'an-O', 'increase-O', 'in-O', 'necrosis-B-Disease', 'markers-O', '.-O']
['CAA-B-Chemical', 'but-O', 'not-O', 'acrolein-B-Chemical', 'inhibited-O', 'the-O', 'cysteine-O', 'proteases-O', 'caspase-O', ',-O', '3-O', ',-O', 'caspase-O', ',-O', '8-O', 'and-O', 'cathepsin-O', 'B-O', '.-O']
['Caspase-O', 'activation-O', 'by-O', 'cisplatin-B-Chemical', 'was-O', 'inhibited-O', 'by-O', 'CAA-B-Chemical', '.-O']
['In-O', 'cells-O', 'stained-O', 'with-O', 'fluorescent-O', 'dyes-O', 'targeting-O', 'lysosomes-O', ',-O', 'CAA-B-Chemical', 'induced-O', 'an-O', 'increase-O', 'in-O', 'lysosomal-O', 'size-O', 'and-O', 'lysosomal-O', 'leakage-O', '.-O']
['The-O', 'effects-O', 'of-O', 'CAA-B-Chemical', 'on-O', 'cysteine-B-Chemical', 'protease-O', 'activities-O', 'and-O', 'thiols-O', 'could-O', 'be-O', 'reproduced-O', 'in-O', 'cell-O', 'lysate-O', '.-O']
['Acidification-O', ',-O', 'which-O', 'slowed-O', 'the-O', 'reaction-O', 'of-O', 'CAA-B-Chemical', 'with-O', 'thiol-O', 'donors-O', ',-O', 'could-O', 'also-O', 'attenuate-O', 'effects-O', 'of-O', 'CAA-B-Chemical', 'on-O', 'necrosis-B-Disease', 'markers-O', ',-O', 'thiol-O', 'depletion-O', 'and-O', 'cysteine-O', 'protease-O', 'inhibition-O', 'in-O', 'living-O', 'cells-O', '.-O']
['Thus-O', ',-O', 'CAA-B-Chemical', 'directly-O', 'reacts-O', 'with-O', 'cellular-O', 'protein-O', 'and-O', 'non-O', ',-O', 'protein-O', 'thiols-O', ',-O', 'mediating-O', 'its-O', 'toxicity-O', 'on-O', 'hRPTEC-O', '.-O']
['This-O', 'effect-O', 'can-O', 'be-O', 'reduced-O', 'by-O', 'acidification-O', '.-O']
['Therefore-O', ',-O', 'urinary-O', 'acidification-O', 'could-O', 'be-O', 'an-O', 'option-O', 'to-O', 'prevent-O', 'IFO-B-Disease', 'nephropathy-I-Disease']
['Stereological-O', 'methods-O', 'reveal-O', 'the-O', 'robust-O', 'size-O', 'and-O', 'stability-O', 'of-O', 'ectopic-O', 'hilar-O', 'granule-O', 'cells-O', 'after-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'status-B-Disease', 'epilepticus-I-Disease', 'in-O', 'the-O', 'adult-O', 'rat-O', '.-O']
['Following-O', 'status-B-Disease', 'epilepticus-I-Disease', 'in-O', 'the-O', 'rat-O', ',-O', 'dentate-O', 'granule-O', 'cell-O', 'neurogenesis-O', 'increases-O', 'greatly-O', ',-O', 'and-O', 'many-O', 'of-O', 'the-O', 'new-O', 'neurons-O', 'appear-O', 'to-O', 'develop-O', 'ectopically-O', ',-O', 'in-O', 'the-O', 'hilar-O', 'region-O', 'of-O', 'the-O', 'hippocampal-O', 'formation-O', '.-O']
['It-O', 'has-O', 'been-O', 'suggested-O', 'that-O', 'the-O', 'ectopic-B-Disease', 'hilar-O', 'granule-O', 'cells-O', 'could-O', 'contribute-O', 'to-O', 'the-O', 'spontaneous-B-Disease', 'seizures-I-Disease', 'that-O', 'ultimately-O', 'develop-O', 'after-O', 'status-B-Disease', 'epilepticus-I-Disease', '.-O']
['However-O', ',-O', 'the-O', 'population-O', 'has-O', 'never-O', 'been-O', 'quantified-O', ',-O', 'so-O', 'it-O', 'is-O', 'unclear-O', 'whether-O', 'it-O', 'is-O', 'substantial-O', 'enough-O', 'to-O', 'have-O', 'a-O', 'strong-O', 'influence-O', 'on-O', 'epileptogenesis-B-Disease', '.-O']
['To-O', 'quantify-O', 'this-O', 'population-O', ',-O', 'the-O', 'total-O', 'number-O', 'of-O', 'ectopic-I-Disease', 'hilar-O', 'granule-O', 'cells-O', 'was-O', 'estimated-O', 'using-O', 'unbiased-O', 'stereology-O', 'at-O', 'different-O', 'times-O', 'after-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'status-B-Disease', 'epilepticus-I-Disease', '.-O']
['The-O', 'number-O', 'of-O', 'hilar-O', 'neurons-O', 'immunoreactive-O', 'for-O', 'Prox-O', ',-O', '1-O', ',-O', 'a-O', 'granule-O', ',-O', 'cell-O', ',-O', 'specific-O', 'marker-O', ',-O', 'was-O', 'estimated-O', 'using-O', 'the-O', 'optical-O', 'fractionator-O', 'method-O', '.-O']
['The-O', 'results-O', 'indicate-O', 'that-O', 'the-O', 'size-O', 'of-O', 'the-O', 'hilar-O', 'ectopic-I-Disease', 'granule-O', 'cell-O', 'population-O', 'after-O', 'status-B-Disease', 'epilepticus-I-Disease', 'is-O', 'substantial-O', ',-O', 'and-O', 'stable-O', 'over-O', 'time-O', '.-O']
['Interestingly-O', ',-O', 'the-O', 'size-O', 'of-O', 'the-O', 'population-O', 'appears-O', 'to-O', 'be-O', 'correlated-O', 'with-O', 'the-O', 'frequency-O', 'of-O', 'behavioral-O', 'seizures-B-Disease', ',-O', 'because-O', 'animals-O', 'with-O', 'more-O', 'ectopic-O', 'granule-O', 'cells-O', 'in-O', 'the-O', 'hilus-O', 'have-O', 'more-O', 'frequent-O', 'behavioral-O', 'seizures-B-Disease', '.-O']
['The-O', 'hilar-O', 'ectopic-O', 'granule-O', 'cell-O', 'population-O', 'does-O', 'not-O', 'appear-O', 'to-O', 'vary-O', 'systematically-O', 'across-O', 'the-O', 'septotemporal-O', 'axis-O', ',-O', 'although-O', 'it-O', 'is-O', 'associated-O', 'with-O', 'an-O', 'increase-O', 'in-O', 'volume-O', 'of-O', 'the-O', 'hilus-B-Disease', '.-O']
['The-O', 'results-O', 'provide-O', 'new-O', 'insight-O', 'into-O', 'the-O', 'potential-O', 'role-O', 'of-O', 'ectopic-O', 'hilar-O', 'granule-O', 'cells-O', 'in-O', 'the-O', 'pilocarpine-B-Chemical', 'model-O', 'of-O', 'temporal-B-Disease', 'lobe-I-Disease', 'epilepsy-I-Disease']
['A-O', 'prospective-O', ',-O', 'open-O', ',-O', 'label-O', 'trial-O', 'of-O', 'galantamine-B-Chemical', 'in-O', 'autistic-B-Disease', 'disorder-I-Disease', '.-O']
['OBJECTIVE-O', ':-O', 'Post-O', ',-O', 'mortem-O', 'studies-O', 'have-O', 'reported-O', 'abnormalities-O', 'of-O', 'the-O', 'cholinergic-O', 'system-O', 'in-O', 'autism-B-Disease', '.-O']
['The-O', 'purpose-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'assess-O', 'the-O', 'use-O', 'of-O', 'galantamine-B-Chemical', ',-O', 'an-O', 'acetylcholinesterase-O', 'inhibitor-O', 'and-O', 'nicotinic-O', 'receptor-O', 'modulator-O', ',-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'interfering-O', 'behaviors-O', 'in-O', 'children-O', 'with-O', 'autism-B-Disease', '.-O']
['METHODS-O', ':-O', 'Thirteen-O', 'medication-O', ',-O', 'free-O', 'children-O', 'with-O', 'autism-B-Disease', '(-O', 'mean-O', 'age-O', ',-O', '8-O', '.-O']
['8-O', '+-O', '3-O', '.-O']
['5-O', 'years-O', ')-O', 'participated-O', 'in-O', 'a-O', '12-O', ',-O', 'week-O', ',-O', 'open-O', ',-O', 'label-O', 'trial-O', 'of-O', 'galantamine-B-Chemical', '.-O']
['Patients-O', 'were-O', 'rated-O', 'monthly-O', 'by-O', 'parents-O', 'on-O', 'the-O', 'Aberrant-O', 'Behavior-O', 'Checklist-O', '(-O', 'ABC-O', ')', 'and-O', 'the-O', 'Conners-O', 'x-O', 'Parent-O', 'Rating-O', 'Scale-O', ',-O', 'Revised-O', ',-O', 'and-O', 'by-O', 'a-O', 'physician-O', 'using-O', 'the-O', 'Children-O', 'x-O', 's-O', 'Psychiatric-O', 'Rating-O', 'Scale-O', 'and-O', 'the-O', 'Clinical-O', 'Global-O', 'Impressions-O', 'scale-O', '.-O']
['RESULTS-O', ':-O', 'Patients-O', 'showed-O', 'a-O', 'significant-O', 'reduction-O', 'in-O', 'parent-O', ',-O', 'rated-O', 'irritability-O', 'and-O', 'social-O', 'withdrawal-O', 'on-O', 'the-O', 'ABC-O', 'as-O', 'well-O', 'as-O', 'significant-O', 'improvements-O', 'in-O', 'emotional-O', 'lability-O', 'and-O', 'inattention-O', 'on-O', 'the-O', 'Conners-O', 'x-O', 'Parent-O', 'Rating-O', 'Scale-O', '--O', 'Revised-O', '.-O']
['Similarly-O', ',-O', 'clinician-O', 'ratings-O', 'showed-O', 'reductions-O', 'in-O', 'the-O', 'anger-B-Disease', 'subscale-O', 'of-O', 'the-O', 'Children-O', 'x-O', 's-O', 'Psychiatric-O', 'Rating-O', 'Scale-O', '.-O']
['Eight-O', 'of-O', '13-O', 'participants-O', 'were-O', 'rated-O', 'as-O', 'responders-O', 'on-O', 'the-O', 'basis-O', 'of-O', 'their-O', 'improvement-O', 'scores-O', 'on-O', 'the-O', 'Clinical-O', 'Global-O', 'Impressions-O', 'scale-O', '.-O']
['Overall-O', ',-O', 'galantamine-B-Chemical', 'was-O', 'well-O', ',-O', 'tolerated-O', ',-O', 'with-O', 'no-O', 'significant-O', 'adverse-O', 'effects-O', 'apart-O', 'from-O', 'headaches-B-Disease', 'in-O', 'one-O', 'patient-O', '.-O']
['CONCLUSION-O', ':-O', 'In-O', 'this-O', 'open-O', 'trial-O', ',-O', 'galantamine-B-Chemical', 'was-O', 'well-O', ',-O', 'tolerated-O', 'and-O', 'appeared-O', 'to-O', 'be-O', 'beneficial-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'interfering-O', 'behaviors-O', 'in-O', 'children-O', 'with-O', 'autism-B-Disease', ',-O', 'particularly-O', 'aggression-B-Disease', ',-O', 'behavioral-O', 'dyscontrol-B-Disease', ',-O', 'and-O', 'inattention-B-Disease']
['Randomized-O', 'comparison-O', 'of-O', 'olanzapine-B-Chemical', 'versus-O', 'risperidone-B-Chemical', 'for-O', 'the-O', 'treatment-O', 'of-O', 'first-O', ',-O', 'episode-O', 'schizophrenia-B-Disease', ':-O', '4-O', ',-O', 'month-O', 'outcomes-O', '.-O']
['OBJECTIVE-O', ':-O', 'The-O', 'authors-O', 'compared-O', '4-O', '--O', 'month-O', 'treatment-O', 'outcomes-O', 'for-O', 'olanzapine-B-Chemical', 'versus-O', 'risperidone-B-Chemical', 'in-O', 'patients-O', 'with-O', 'first-O', '--O', 'episode-O', 'schizophrenia-B-Disease', 'spectrum-O', 'disorders-I-Disease', '.-O']
['METHOD-O', ':-O', 'One-O', 'hundred-O', 'twelve-O', 'subjects-O', '(-O', '70-O', '%-O', 'male-O', ';-O', 'mean-O', 'age-O', '='-O', '23-O', '.-O']
['3-O', 'years-O', '[O', 'SD-O', '=-O', '5-O', '.-O']
['1-O', '])', 'with-O', 'first-O', ',-O', 'episode-O', 'schizophrenia-B-Disease', '(-O', '75-O', '),', 'schizophreniform-B-Disease', 'disorder-I-Disease', '(-O', '17-O', '),', 'or-O', 'schizoaffective-B-Disease', 'disorder-I-Disease', '(-O', '8-O', ')-O', 'were-O', 'randomly-O', 'assigned-O', 'to-O', 'treatment-O', 'with-O', 'olanzapine-B-Chemical', '(-O', '2-O', '.-O']
['5-O', ',-O', '20-O', 'mg-O', '/-O', 'day-O', ')-O', 'or-O', 'risperidone-B-Chemical', '(-O', '1-O', ',-O', '6-O', 'mg-O', '/-O', 'day-O', ').-O', 'RESULTS-O', ':-O', 'Response-O', 'rates-O', 'did-O', 'not-O', 'significantly-O', 'differ-O', 'between-O', 'olanzapine-B-Chemical', '(-O', '43-O', '.-O']
['7-O', ',-O', '95-O', '%-O', 'CI-O', '=-O', '28-O', '.-O']
['8-O', '%-O', '58-O', '.-O']
['6-O', ')-O', 'and-O', 'risperidone-B-Chemical', '(--O', '54-O', '.-O']
['3-O', ',-O', '95-O', '%-O', 'CI-O', '=-O', '39-O', '.-O']
['9-O', '%-O', '68-O', '.-O']
['7-O', ').-O', 'Among-O', 'those-O', 'responding-O', 'to-O', 'treatment-O', ',-O', 'more-O', 'subjects-O', 'in-O', 'the-O', 'olanzapine-B-Chemical', 'group-O', '(-O', '40-O', '.-O']
['9-O', ',-O', '95-O', '%-O', 'CI-O', '=', '16-O', '.-O']
['8-O', '%-O', '65-O', '.-O']
['0-O', ')-O', 'than-O', 'in-O', 'the-O', 'risperidone-B-Chemical', 'group-O', '(-O', '18-O', '.-O']
['9-O', ',-O', '95-O', '%-O', 'CI-O', '=-O', '0-O', '%-O', '39-O', '.-O']
['2-O', ')-O', 'had-O', 'subsequent-O', 'ratings-O', 'not-O', 'meeting-O', 'response-O', 'criteria-O', '.-O']
['Negative-O', 'symptom-O', 'outcomes-O', 'and-O', 'measures-O', 'of-O', 'parkinsonism-B-Disease', 'and-O', 'akathisia-B-Disease', 'did-O', 'not-O', 'differ-O', 'between-O', 'medications-O', '.-O']
['Extrapyramidal-O', 'symptom-O', 'severity-O', 'scores-O', 'were-O', '1-O', '.-O']
['4-O', '(-O', '95-O', '%-O', 'CI-O', '='-O', '1-O', '.-O']
['2-O', ',-O', '1-O', '.-O']
['6-O', ')-O', 'with-O', 'risperidone-B-Chemical', 'and-O', '1-O', '.-O']
['2-O', '(-O', '95-O', '%-O', 'CI-O', '=', '1-O', '.-O']
['0-O', ',-O', '1-O', '.-O']
['4-O', ')-O', 'with-O', 'olanzapine-B-Chemical', '.-O']
['Significantly-O', 'more-O', 'weight-O', 'gain-O', 'occurred-O', 'with-O', 'olanzapine-B-Chemical', 'than-O', 'with-O', 'risperidone-B-Chemical', ':-O', 'the-O', 'increase-O', 'in-O', 'weight-O', 'at-O', '4-O', 'months-O', 'relative-O', 'to-O', 'baseline-O', 'weight-O', 'was-O', '17-O', '.-O']
['3-O', '(-O', '95-O', '%-O', 'CI-O', '=-O', '14-O', '.-O']
['2-O', '%-O', '20-O', '.-O']
['5-O', ')-O', 'with-O', 'olanzapine-B-Chemical', 'and-O', '11-O', '.-O']
['3-O', '(-O', '95-O', '%-O', 'CI-O', '=', '8-O', '.-O']
['4-O', '%-O', '14-O', '.-O']
['3-O', ')-O', 'with-O', 'risperidone-B-Chemical', '.-O']
['Body-O', 'mass-O', 'index-O', 'at-O', 'baseline-O', 'and-O', 'at-O', '4-O', 'months-O', 'was-O', '24-O', '.-O']
['3-O', '(-O', '95-O', '%-O', 'CI-O', '=', '22-O', '.-O']
['8-O', ',-O', '25-O', '.-O']
['7-O', ')-O', 'versus-O', '28-O', '.-O']
['2-O', '(-O', '95-O', '%-O', 'CI-O', '=-O', '26-O', '.-O']
['7-O', ',-O', '29-O', '.-O']
['7-O', ')-O', 'with-O', 'olanzapine-B-Chemical', 'and-O', '23-O', '.-O']
['9-O', '(-O', '95-O', '%-O', 'CI-O', '=-O', '22-O', '.-O']
['5-O', ',-O', '25-O', '.-O']
['3-O', ')-O', 'versus-O', '26-O', '.-O']
['7-O', '(-O', '95-O', '%-O', 'CI-O', '=-O', '25-O', '.-O']
['2-O', ',-O', '28-O', '.-O']
['2-O', ')-O', 'with-O', 'risperidone-B-Chemical', '.-O']
['CONCLUSIONS-O', ':-O', 'Clinical-O', 'outcomes-O', 'with-O', 'risperidone-B-Chemical', 'were-O', 'equal-O', 'to-O', 'those-O', 'with-O', 'olanzapine-B-Chemical', ',-O', 'and-O', 'response-O', 'may-O', 'be-O', 'more-O', 'stable-O', '.-O']
['Olanzapine-B-Chemical', 'may-O', 'have-O', 'an-O', 'advantage-O', 'for-O', 'motor-O', 'side-O', 'effects-O', '.-O']
['Both-O', 'medications-O', 'caused-O', 'substantial-O', 'rapid-O', 'weight-O', 'gain-O', ',-O', 'but-O', 'weight-O', 'gain-O', 'was-O', 'greater-O', 'with-O', 'olanzapine-B-Chemical']
['Early-O', 'paracentral-O', 'visual-O', 'field-O', 'loss-B-Disease', 'in-O', 'patients-O', 'taking-O', 'hydroxychloroquine-B-Chemical', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'review-O', 'the-O', 'natural-O', 'history-O', 'and-O', 'ocular-O', 'and-O', 'systemic-O', 'adverse-O', 'effects-O', 'of-O', 'patients-O', 'taking-O', 'hydroxychloroquine-B-Chemical', 'sulfate-O', 'who-O', 'attended-O', 'an-O', 'ophthalmic-O', 'screening-O', 'program-O', '.-O']
['DESIGN-O', ':-O', 'Retrospective-O', 'study-O', '.-O']
['RESULTS-O', ':-O', 'Records-O', 'of-O', '262-O', 'patients-O', 'who-O', 'were-O', 'taking-O', 'hydroxychloroquine-B-Chemical', 'and-O', 'screened-O', 'in-O', 'the-O', 'Department-O', 'of-O', 'Ophthalmology-O', 'were-O', 'reviewed-O', '.-O']
['Of-O', 'the-O', '262-O', 'patients-O', ',-O', '14-O', '(-O', '18-O', ')-O', 'of-O', '76-O', 'who-O', 'had-O', 'stopped-O', 'treatment-O', 'at-O', 'the-O', 'time-O', 'of-O', 'the-O', 'study-O', 'experienced-O', 'documented-O', 'adverse-O', 'effects-O', '.-O']
['Systemic-O', 'adverse-O', 'effects-O', 'occurred-O', 'in-O', '8-O', 'patients-O', '(-O', '10-O', '.-O']
['5-O', ')-O', 'and-O', 'ocular-O', 'adverse-O', 'effects-O', ',-O', 'in-O', '5-O', '(-O', '6-O', '.-O']
['5-O', ').-O', 'Thirty-O', ',-O', 'five-O', 'patients-O', '(-O', '13-O', '.-O']
['4-O', ')-O', 'had-O', 'visual-B-Disease', 'field-O', 'abnormalities-I-Disease', ',-O', 'which-O', 'were-O', 'attributed-O', 'to-O', 'hydroxychloroquine-B-Chemical', 'treatment-O', 'in-O', '4-O', 'patients-O', '(-O', '1-O', '.-O']
['5-O', ').-O', 'Three-O', 'of-O', 'the-O', '4-O', 'patients-O', 'were-O', 'taking-O', 'less-O', 'than-O', '6-O', '.-O']
['5-O', 'mg-O', '/-O', 'kg-O', 'per-O', 'day-O', 'and-O', 'all-O', 'patients-O', 'had-O', 'normal-O', 'renal-O', 'and-O', 'liver-O', 'function-O', 'test-O', 'results-O', '.-O']
['CONCLUSIONS-O', ':-O', 'The-O', 'current-O', 'study-O', 'used-O', 'a-O', 'protocol-O', 'of-O', 'visual-O', 'acuity-O', 'and-O', 'color-O', 'vision-O', 'assessment-O', ',-O', 'funduscopy-O', ',-O', 'and-O', 'Humphrey-O', '10-O', ',-O', '2-O', 'visual-O', 'field-O', 'testing-O', 'and-O', 'shows-O', 'that-O', 'visual-O', 'field-O', 'defects-B-Disease', 'appeared-O', 'before-O', 'any-O', 'corresponding-O', 'changes-O', 'in-O', 'any-O', 'other-O', 'tested-O', 'clinical-O', 'parameters-O', ';-O', 'the-O', 'defects-B-Disease', 'were-O', 'reproducible-O', 'and-O', 'the-O', 'test-O', 'parameters-O', 'were-O', 'reliable-O', '.-O']
['Patients-O', 'taking-O', 'hydroxychloroquine-B-Chemical']
['Peri-O', ',-O', 'operative-O', 'atrioventricular-B-Disease', 'block-I-Disease', 'as-O', 'a-O', 'result-O', 'of-O', 'chemotherapy-O', 'with-O', 'epirubicin-B-Chemical', 'and-O', 'paclitaxel-B-Chemical', '.-O']
['A-O', '47-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'presented-O', 'for-O', 'mastectomy-O', 'and-O', 'immediate-O', 'latissimus-O', 'dorsi-O', 'flap-O', 'reconstruction-O', 'having-O', 'been-O', 'diagnosed-O', 'with-O', 'carcinoma-B-Disease', 'of-O', 'the-O', 'breast-B-Disease', '6-O', 'months-O', 'previously-O', '.-O']
['In-O', 'the-O', 'preceding-O', 'months-O', 'she-O', 'had-O', 'received-O', 'neo-O', 'adjuvant-O', 'chemotherapy-O', 'with-O', 'epirubicin-B-Chemical', ',-O', 'paclitaxel-B-Chemical', '(-O', 'Taxol-B-Chemical', ')', 'and-O', 'cyclophosphamide-B-Chemical', '.-O']
['This-O', 'had-O', 'been-O', 'apparently-O', 'uncomplicated-O', 'and-O', 'she-O', 'had-O', 'maintained-O', 'a-O', 'remarkably-O', 'high-O', 'level-O', 'of-O', 'physical-O', 'activity-O', '.-O']
['She-O', 'was-O', 'found-O', 'to-O', 'be-O', 'bradycardic-B-Disease', 'at-O', 'pre-O', ',-O', 'operative-O', 'assessment-O', 'but-O', 'had-O', 'no-O', 'cardiac-O', 'symptoms-O', '.-O']
['Second-O', 'degree-O', 'Mobitz-O', 'type-O', 'II-O', 'atrioventricular-B-Disease', 'block-I-Disease', 'was-O', 'diagnosed-O', 'on-O', 'electrocardiogram-O', ',-O', 'and-O', 'temporary-O', 'transvenous-O', 'ventricular-O', 'pacing-O', 'instituted-O', 'in-O', 'the-O', 'peri-O', ',', 'operative-O', 'period-O', '.-O']
['We-O', 'discuss-O', 'how-O', 'evidence-O', ',-O', 'based-O', 'guidelines-O', 'would-O', 'not-O', 'have-O', 'been-O', 'helpful-O', 'in-O', 'this-O', 'case-O', ',-O', 'and-O', 'how-O', 'chemotherapy-O', 'can-O', 'exhibit-O', 'substantial-O', 'cardiotoxicity-B-Disease']
['Risks-O', 'and-O', 'benefits-O', 'of-O', 'COX-2-B-Chemical', 'inhibitors-O', 'vs-O', 'non-O', ',-O', 'selective-O', 'NSAIDs-B-Chemical', ':-O', 'does-O', 'their-O', 'cardiovascular-B-Disease', 'risk-O', 'exceed-O', 'their-O', 'gastrointestinal-B-Disease', 'benefit-O', '?-O', 'A-O', 'retrospective-O', 'cohort-O', 'study-O', '.-O']
['OBJECTIVES-O', ':-O', 'The-O', 'risk-O', 'of-O', 'acute-B-Disease', 'myocardial-I-Disease', 'infarction-I-Disease', '(-O', 'AMI-B-Chemical', ')-O', 'with-O', 'COX-2-B-Chemical', 'inhibitors-O', 'may-O', 'offset-O', 'their-O', 'gastrointestinal-O', '(-O', 'GI-O', ')-O', 'benefit-O', 'compared-O', 'with-O', 'non-O', ',-O', 'selective-O', '(-O', 'NS-O', ')-O', 'non-steroidal-O', 'anti-inflammatory-O', 'drugs-O', '(-O', 'NSAIDs-B-Chemical', ')-O', '.', 'We-O', 'aimed-O', 'to-O', 'compare-O', 'the-O', 'risks-O', 'of-O', 'hospitalization-O', 'for-O', 'AMI-B-Disease', 'and-O', 'GI-O', 'bleeding-O', 'among-O', 'elderly-O', 'patients-O', 'using-O', 'COX-2-B-Chemical', 'inhibitors-O', ',-O', 'NS-O', ',-O', 'NSAIDs-B-Chemical', 'and-O', 'acetaminophen-B-Chemical', '.-O']
['METHODS-O', ':-O', 'We-O', 'conducted-O', 'a-O', 'retrospective-O', 'cohort-O', 'study-O', 'using-O', 'administrative-O', 'data-O', 'of-O', 'patients-O', '>-O', 'or-O', '=-O', '65-O', 'years-O', 'of-O', 'age-O', 'who-O', 'filled-O', 'a-O', 'prescription-O', 'for-O', 'NSAID-B-Chemical', 'or-O', 'acetaminophen-B-Chemical', 'during-O', '1999-O', ',-O', '2002-O', '.-O']
['Outcomes-O', 'were-O', 'compared-O', 'using-O', 'Cox-O', 'regression-O', 'models-O', 'with-O', 'time-O', ',-O', 'dependent-O', 'exposures-O', '.-O']
['RESULTS-O', ':-O', 'Person-O', ',-O', 'years-O', 'of-O', 'exposure-O', 'among-O', 'non-O', ',-O', 'users-O', 'of-O', 'aspirin-B-Chemical', 'were-O', ':-O', '75-O', ',-O', '761-O', 'to-O', 'acetaminophen-B-Chemical', ',-O', '42-O', ',-O', '671-O', 'to-O', 'rofecoxib-B-Chemical', '65-O', ',-O', '860-O', 'to-O', 'celecoxib-B-Chemical', ',-O', 'and-O', '37-O', ',-O', '495-O', 'to-O', 'NS-O', ',-O', 'NSAIDs-B-Chemical', '.-O']
['Among-O', 'users-O', 'of-O', 'aspirin-B-Chemical', ',-O', 'they-O', 'were-O', ':-O', '14-O', ',-O', '671-O', 'to-O', 'rofecoxib-B-Chemical', ',-O', '22-O', ',-O', '875-O', 'to-O', 'celecoxib-B-Chemical', ',-O', '9-O', ',-O', '832-O', 'to-O', 'NS-O', ',-O', 'NSAIDs-O', 'and-O', '38-O', ',-O', '048-O', 'to-O', 'acetaminophen-B-Chemical', '.-O']
['Among-O', 'non-O', ',-O', 'users-O', 'of-O', 'aspirin-B-Chemical', ',-O', 'the-O', 'adjusted-O', 'hazard-O', 'ratios-O', '(-O', '95-O', '%-O', 'confidence-O', 'interval-O', ')-O', 'of-O', 'hospitalization-O', 'for-O', 'AMI-B-Disease', '/-O', 'GI-B-Disease', 'vs-O', 'the-O', 'acetaminophen-B-Chemical', '(-O', 'with-O', 'no-O', 'aspirin-B-Chemical', ')-O', 'group-O', 'were-O', ':-O', 'rofecoxib-B-Chemical', '1-O', '.-O']
['27-O', '(-O', '1-O', '.-O']
['13-O', ',-O', '1-O', '.-O']
['42-O', ')-O', 'celecoxib-B-Chemical', '0-O', '.-O']
['93-O', '(-O', '0-O', '.-O']
['83-O', ',-O', '1-O', '.-O']
['03-O', ')-O', 'naproxen-B-Chemical', '1-O', '.-O']
['59-O', '(-O', '1-O', '.-O']
['31-O', ',-O', '1-O', '.-O']
['93-O', '),-O', 'diclofenac-B-Chemical', '1-O', '.-O']
['17-O', '(-O', '0-O', '.-O']
['99-O', ',-O', '1-O', '.-O']
['38-O', ')-O', 'and-O', 'ibuprofen-B-Chemical', '1-O', '.-O']
['05-O', '(-O', '0-O', '.-O']
['74-O', ',-O', '1-O', '.-O']
['51-O', ').-O', 'Among-O', 'users-O', 'of-O', 'aspirin-B-Chemical', ',-O', 'they-O', 'were-O', ':-O', 'rofecoxib-B-Chemical', '1-O', '.-O']
['73-O', '(-O', '1-O', '.-O']
['52-O', ',-O', '1-O', '.-O']
['98-O', '),-O', 'celecoxib-B-Chemical', '1-O', '.-O']
['34-O', '(-O', '1-O', '.-O']
['19-O', ',-O', '1-O', '.-O']
['52-O', '),-O', 'ibuprofen-B-Chemical', '1-O', '.-O']
['51-O', '(-O', '0-O', '.-O']
['95-O', ',-O', '2-O', '.-O']
['41-O', '),-O', 'diclofenac-B-Chemical', '1-O', '.-O']
['69-O', '(-O', '1-O', '.-O']
['35-O', ',-O', '2-O', '.-O']
['10-O', ')-O', 'naproxen-B-Chemical', '1-O', '.-O']
['35-O', '(-O', '0-O', '.-O']
['97-O', ',-O', '1-O', '.-O']
['88-O', ')-O', 'and-O', 'acetaminophen-B-Chemical', '1-O', '.-O']
['29-O', '(-O', '1-O', '.-O']
['17-O', ',-O', '1-O', '.-O']
['42-O', ').-O', 'CONCLUSION-O', ':-O', 'Among-O', 'non-O', ',-O', 'users-O', 'of-O', 'aspirin-B-Chemical', ',-O', 'naproxen-B-Chemical', 'seemed-O', 'to-O', 'carry-O', 'the-O', 'highest-O', 'risk-O', 'for-O', 'AMI-B-Disease', '/', 'GI-B-Disease', 'bleeding-I-Disease', '.-O']
['The-O', 'AMI-B-Chemical', '/-O', 'GI-B-Disease', 'toxicity-O', 'of-O', 'celecoxib-B-Chemical', 'was-O', 'similar-O', 'to-O', 'that-O', 'of-O', 'acetaminophen-B-Chemical', 'and-O', 'seemed-O', 'to-O', 'be-O', 'better-O', 'than-O', 'those-O', 'of-O', 'rofecoxib-B-Chemical', 'and-O', 'NS-O', ',-O', 'NSAIDs-O', '.-O']
['Among-O', 'users-O', 'of-O', 'aspirin-B-Chemical', ',-O', 'both-O', 'celecoxib-B-Chemical', 'and-O', 'naproxen-B-Chemical']
['Quinine-B-Chemical', ',-O', 'induced-O', 'arrhythmia-B-Disease', 'in-O', 'a-O', 'patient-O', 'with-O', 'severe-O', 'malaria-B-Disease', '.-O']
['It-O', 'was-O', 'reported-O', 'that-O', 'there-O', 'was-O', 'a-O', 'case-O', 'of-O', 'severe-O', 'malaria-B-Disease', 'patient-O', 'with-O', 'jaundice-B-Disease', 'who-O', 'presented-O', 'with-O', 'arrhythmia-B-Disease', '(-O', 'premature-O', 'ventricular-O', 'contraction-O', ')-O', 'while-O', 'getting-O', 'quinine-B-Chemical', 'infusion-O', 'was-O', 'reported-O', '.-O']
['A-O', 'man-O', ',-O', '25-O', 'years-O', 'old-O', ',-O', 'was-O', 'admitted-O', 'to-O', 'hospital-O', 'with-O', 'high-O', 'fever-B-Disease', ',-O', 'chill-B-Disease', ',-O', 'vomiting-B-Disease', ',-O', 'jaundice-B-Disease', '.-O']
['The-O', 'patient-O', 'was-O', 'fully-O', 'conscious-O', ',-O', 'blood-O', 'pressure-O', '120-O', '/-O', '80-O', 'mmHg-O', ',-O', 'pulse-O', 'rate-O', '100-O', 'x-O', '/-O', 'minute-O', ',-O', 'regular-O', '.-O']
['On-O', 'admission-O', ',-O', 'laboratory-O', 'examination-O', 'showed-O', 'Plasmodium-B-Disease', 'falciparum-O', '(+++)-O', 'total-O', 'bilirubin-B-Chemical', '8-O', '.-O']
['25-O', 'mg-O', '/-O', 'dL-O', ',-O', 'conjugated-O', 'bilirubin-B-Chemical', '4-O', '.-O']
['36-O', 'mg-O', '/-O', 'dL-O', ',-O', 'unconjugated-O', 'bilirubin-B-Chemical', '3-O', '.-O']
['89-O', 'mg-O', '/-O', 'dL-O', ',-O', 'potassium-B-Chemical', '3-O', '.-O']
['52-O', 'meq-O', '/-O', 'L-O', 'Patient-O', 'was-O', 'diagnosed-O', 'as-O', 'severe-B-Disease', 'malaria-B-Disease', 'with-O', 'jaundice-B-Disease', 'and-O', 'got-O', 'quinine-B-Chemical', 'infusion-O', 'in-O', 'dextrose-O', '5-O', '%-O', '500-O', 'mg-O', '/-O', '8-O', 'hour-O', '.-O']
['On-O', 'the-O', 'second-O', 'day-O', 'the-O', 'patient-O', 'had-O', 'vomitus-O', ',-O', 'diarrhea-O', ',-O', 'tinnitus-B-Disease', ',-O', 'loss-O', 'of-O', 'hearing-B-Disease', '.-O']
['After-O', '30-O', 'hours-O', 'of-O', 'quinine-B-Chemical', 'infusion-O', 'the-O', 'patient-O', 'felt-O', 'palpitation-O', 'and-O', 'electrocardiography-O', '(-O', 'ECG-O', ')-O', 'recording-O', 'showed-O', 'premature-O', 'ventricular-O', 'contraction-O', '(-O', 'PVC-O', ')-O', '>O', '5-O', 'x-O', '/-O', 'minute-O', ',-O', 'trigemini-O', ',-O', 'constant-O', 'type-O', '--O', 'sinoatrial-O', 'block-I-Disease', ',-O', 'positive-O', 'U-O', 'wave-O', '.-O']
['He-O', 'was-O', 'treated-O', 'with-O', 'lidocaine-B-Chemical', '50-O', 'mg-O', 'intravenously-O', 'followed-O', 'by-O', 'infusion-O', '1500-O', 'mg-O', 'in-O', 'dextrose-O', '5-O', '%-O', '24-O', 'hour-O', 'and-O', 'potassium-B-Chemical', 'aspartate-B-Chemical', 'tablet-O', '.-O']
['Quinine-B-Chemical', 'infusion-O', 'was-O', 'discontinued-O', 'and-O', 'changed-O', 'with-O', 'sulfate-O', 'quinine-B-Chemical', 'tablets-O', '.-O']
['Three-O', 'hours-O', 'later-O', 'the-O', 'patient-O', 'felt-O', 'better-O', ',-O', 'the-O', 'frequency-O', 'of-O', 'PVC-O', 'reduced-O', 'to-O', '4-O', ',-O', '5-O', 'x-O', '/-O', 'minute-O', 'and-O', 'on-O', 'the-O', 'third-O', 'day-O', 'ECG-O', 'was-O', 'normal-O', ',-O', 'potassium-B-Chemical', 'level-O', 'was-O', '3-O', '.-O']
['34-O', 'meq-O', '/-O', 'L-O', '.-O']
['He-O', 'was-O', 'discharged-O', 'on-O', '7th-O', 'day-O', 'in-O', 'good-O', 'condition-O', '.-O']
['Quinine-B-Chemical', ',-O', 'like-O', 'quinidine-B-Chemical', ',-O', 'is-O', 'a-O', 'chincona-O', 'alkaloid-O', 'that-O', 'has-O', 'anti-O', ',-O', 'arrhythmic-O', 'property-O', ',-O', 'although-O', 'it-O', 'also-O', 'pro-O', ',-O', 'arrhythmic-O', 'that-O', 'can-O', 'cause-O', 'various-O', 'arrhythmias-O', ',-O', 'including-O', 'severe-O', 'arrhythmia-B-Disease', 'such-O', 'as-O', 'multiple-O', 'PVC-B-Disease', '.-O']
['Administration-O', 'of-O', 'parenteral-O', 'quinine-B-Chemical', 'must-O', 'be-O', 'done-O', 'carefully-O', 'and-O', 'with-O', 'good-O', 'observation-O', 'because-O', 'of-O', 'its-O', 'pro-O', 'arrhythmic-O', 'effect-O', ',-O', 'especially-O', 'in-O', 'older-O', 'patients-O', 'who-O', 'have-O', 'heart-O', 'diseases-B-Disease', 'or-O', 'patients-O', 'with-O', 'electrolyte-O', 'disorder-B-Disease', '(-O', 'hypokalemia-B-Disease', ')-O', 'which-O', 'frequently-O', 'occurs-O', 'due-O', 'to-O', 'vomiting-B-Disease', 'and-O', 'or-O', 'diarrhea-B-Disease', 'in-O', 'malaria-B-Disease', ']
['Penicillamine-B-Chemical', ',-O', 'related-O', 'lichenoid-O', 'dermatitis-B-Disease', 'and-O', 'utility-O', 'of-O', 'zinc-B-Chemical', 'acetate-I-Chemical', 'in-O', 'a-O', 'Wilson-B-Disease', 'disease-I-Disease', 'patient-O', 'with-O', 'hepatic-O', 'presentation-O', ',-O', 'anxiety-O', 'and-O', 'SPECT-O', 'abnormalities-O', '.-O']
['Wilson-O', 'disease-B-Disease', 'is-O', 'an-O', 'autosomal-O', 'recessive-O', 'disorder-O', 'of-O', 'hepatic-O', 'copper-B-Chemical', 'metabolism-O', 'with-O', 'consequent-O', 'copper-B-Chemical', 'accumulation-O', 'and-O', 'toxicity-O', 'in-O', 'many-O', 'tissues-O', 'and-O', 'consequent-O', 'hepatic-O', 'neurologic-O', 'and-O', 'psychiatric-O', 'disorders-O', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'Wilson-B-Disease', 'disease-I-Disease', 'with-O', 'chronic-O', 'liver-B-Disease', 'disease-I-Disease', ';-O', 'moreover-O', ',-O', 'in-O', 'our-O', 'patient-O', ',-O', 'presenting-O', 'also-O', 'with-O', 'high-O', 'levels-O', 'of-O', 'state-O', 'anxiety-O', 'without-O', 'depression-O', ',-O', '99mTc-B-Chemical', ',-O', 'ECD-B-Chemical', ',-O', 'SPECT-O', 'showed-O', 'cortical-O', 'hypoperfusion-O', 'in-O', 'frontal-O', 'lobes-O', ',-O', 'more-O', 'marked-O', 'on-O', 'the-O', 'left-O', 'frontal-O', 'lobe-O', '.-O']
['During-O', 'the-O', 'follow-O', ',-O', 'up-O', 'of-O', 'our-O', 'patient-O', ',-O', 'penicillamine-B-Chemical', 'was-O', 'interrupted-O', 'after-O', 'the-O', 'appearance-O', 'of-O', 'a-O', 'lichenoid-B-Disease', 'dermatitis-I-Disease', ',-O', 'and-O', 'zinc-B-Chemical', 'acetate-O', 'permitted-O', 'to-O', 'continue-O', 'the-O', 'successful-O', 'treatment-O', 'of-O', 'the-O', 'patient-O', 'without-O', 'side-O', ',-O', 'effects-O', '.-O']
['In-O', 'our-O', 'case-O', 'the-O', 'therapy-O', 'with-O', 'zinc-B-Chemical', 'acetate-I-Chemical', 'represented-O', 'an-O', 'effective-O', 'treatment-O', 'for-O', 'a-O', 'Wilson-B-Disease', 'disease-I-Disease', 'patient-O', 'in-O', 'which-O', 'penicillamine-B-Chemical', ',-O', 'related-O', 'side-O', 'effects-O', 'appeared-O', '.-O']
['The-O', 'safety-O', 'of-O', 'the-O', 'zinc-B-Chemical', 'acetate-B-Chemical', 'allowed-O', 'us-O', 'to-O', 'avoid-O', 'other-O', 'potentially-O', 'toxic-O', 'chelating-O', 'drugs-O', ';-O', 'this-O', 'observation-O', 'is-O', 'in-O', 'line-O', 'with-O', 'the-O', 'growing-O', 'evidence-O', 'on-O', 'the-O', 'efficacy-O', 'of-O', 'the-O', 'drug-O', 'in-O', 'the-O', 'treatment-O', 'of-O', 'Wilson-B-Disease', '.-O']
['Since-O', 'most-O', 'of-O', 'Wilson-B-Disease', 'disease-I-Disease', 'penicillamine-B-Chemical', ',-O', 'treated-O', 'patients-O', 'do-O', 'not-O', 'seem-O', 'to-O', 'develop-O', 'this-O', 'skin-O', 'lesion-O', ',-O', 'it-O', 'could-O', 'be-O', 'conceivable-O', 'that-O', 'a-O', 'specific-O', 'genetic-O', 'factor-O', 'is-O', 'involved-O', 'in-O', 'drug-O', 'response-O', '.-O']
['Further-O', 'studies-O', 'are-O', 'needed-O', 'for-O', 'a-O', 'better-O', 'clarification-O', 'of-O', 'Wilson-B-Disease', 'disease-I-Disease', 'therapy-O', ',-O', 'and-O', 'in-O', 'particular-O', 'to-O', 'differentiate-O', 'specific-O', 'therapies-O', 'for-O', 'different-O', 'Wilson-B-Disease', 'disease-I-Disease']
['A-O', 'dramatic-O', 'drop-O', 'in-O', 'blood-O', 'pressure-O', 'following-O', 'prehospital-O', 'GTN-B-Chemical', 'administration-O', '.-O']
['A-O', 'male-O', 'in-O', 'his-O', 'sixties-O', 'with-O', 'no-O', 'history-O', 'of-O', 'cardiac-B-Disease', 'chest-B-Disease', 'pain-I-Disease', 'awoke-O', 'with-O', 'chest-B-Disease', 'pain-I-Disease', 'following-O', 'an-O', 'afternoon-O', 'sleep-O', '.-O']
['The-O', 'patient-O', 'did-O', 'not-O', 'self-O', 'medicate-O', '.-O']
['The-O', 'patient-O', 'x-O', 's-O', 'observations-O', 'were-O', 'within-O', 'normal-O', 'limits-O', ',-O', 'he-O', 'was-O', 'administered-O', 'oxygen-B-Chemical', 'via-O', 'a-O', 'face-O', 'mask-O', 'and-O', 'glyceryl-O', 'trinitrate-B-Chemical', '(-O', 'GTN-O', ')-O', '.', 'Several-O', 'minutes-O', 'after-O', 'the-O', 'GTN-O', 'the-O', 'patient-O', 'experienced-O', 'a-O', 'sudden-O', 'drop-O', 'in-O', 'blood-O', 'pressure-O', 'and-O', 'heart-O', 'rate-O', ',-O', 'this-O', 'was-O', 'rectified-O', 'by-O', 'atropine-B-Chemical', 'sulphate-B-Chemical', 'and-O', 'a-O', 'fluid-O', 'challenge-O', '.-O']
['There-O', 'was-O', 'no-O', 'further-O', 'deterioration-O', 'in-O', 'the-O', 'patient-O', 'x-O', 's-O', 'condition-O', 'during-O', 'transport-O', 'to-O', 'hospital-O', '.-O']
['There-O', 'are-O', 'very-O', 'few-O', 'documented-O', 'case-O', 'like-O', 'this-O', 'in-O', 'the-O', 'prehospital-O', 'scientific-O', 'literature-O', '.-O']
['The-O', 'cause-O', 'appears-O', 'to-O', 'be-O', 'the-O', 'Bezold-O', ',', 'Jarish-O', 'reflex-O', ',', 'stimulation-O', 'of-O', 'the-O', 'ventricular-O', 'walls-O', 'which-O', 'in-O', 'turn-O', 'decreases-O', 'sympathetic-O', 'outflow-O', 'from-O', 'the-O', 'vasomotor-O', 'centre-O', '.-O']
['Prehospital-O', 'care-O', 'providers-O', 'who-O', 'are-O', 'managing-O', 'any-O', 'patient-O', 'with-O', 'a-O', 'syncopal-B-Disease', 'episode-O']
['Acute-B-Disease', 'encephalopathy-I-Disease', 'and-O', 'cerebral-B-Disease', 'vasospasm-I-Disease', 'after-O', 'multiagent-O', 'chemotherapy-O', 'including-O', 'PEG-asparaginase-B-Chemical', 'and-O', 'intrathecal-O', 'cytarabine-B-Chemical', 'for-O', 'the-O', 'treatment-O', 'of-O', 'acute-B-Disease', 'lymphoblastic-I-Disease', 'leukemia-I-Disease', '.-O']
['A-O', '7-O', ',-O', 'year-O', ',-O', 'old-O', 'girl-O', 'with-O', 'an-O', 'unusual-O', 'reaction-O', 'to-O', 'induction-O', 'chemotherapy-O', 'for-O', 'precursor-O', 'B-O', ',-O', 'cell-O', 'acute-B-Disease', 'lymphoblastic-I-Disease', 'leukemia-I-Disease', '(-O', 'ALL-B-Disease', ')-O', 'is-O', 'described-O', '.-O']
['The-O', 'patient-O', 'developed-O', 'acute-O', 'encephalopathy-B-Disease', 'evidenced-O', 'by-O', 'behavioral-O', 'changes-O', ',-O', 'aphasia-I-Disease', ',-O', 'incontinence-I-Disease', ',-O', 'visual-O', 'hallucinations-I-Disease', ',-O', 'and-O', 'right-O', ',-O', 'sided-O', 'weakness-O', 'with-O', 'diffuse-O', 'cerebral-O', 'vasospasm-I-Disease', 'on-O', 'magnetic-O', 'resonance-O', 'angiography-O', 'after-O', 'the-O', 'administration-O', 'of-O', 'intrathecal-O', 'cytarabine-B-Chemical', '.-O']
['Vincristine-B-Chemical', ',-O', 'dexamethasone-B-Chemical', ',-O', 'and-O', 'polyethylene-B-Chemical', 'glycol-asparaginase-B-Chemical']
['Comparison-O', 'of-O', 'valsartan-B-Chemical', '/-O', 'hydrochlorothiazide-B-Chemical', 'combination-O', 'therapy-O', 'at-O', 'doses-O', 'up-O', 'to-O', '320-O', '/-O', '25-O', 'mg-O', 'versus-O', 'monotherapy-O', ':-O', 'a-O', 'double-O', ',-O', 'blind-O', ',-O', 'placebo-O', ',-O', 'controlled-O', 'study-O', 'followed-O', 'by-O', 'long-O', ',-O', 'term-O', 'combination-O', 'therapy-O', 'in-O', 'hypertensive-B-Disease', 'adults-O', '.-O']
['BACKGROUND-O', ':-O', 'One-O', 'third-O', 'of-O', 'patients-O', 'treated-O', 'for-O', 'hypertension-B-Disease', 'attain-O', 'adequate-O', 'blood-O', 'pressure-O', '(-O', 'BP-O', ')-O', 'control-O', ',-O', 'and-O', 'multidrug-O', 'regimens-O', 'are-O', 'often-O', 'required-O', '.-O']
['Given-O', 'the-O', 'lifelong-O', 'nature-O', 'of-O', 'hypertension-B-Disease', ',-O', 'there-O', 'is-O', 'a-O', 'need-O', 'to-O', 'evaluate-O', 'the-O', 'long-O', ',-O', 'term-O', 'efficacy-O', 'and-O', 'tolerability-O', 'of-O', 'higher-O', 'doses-O', 'of-O', 'combination-O', 'anti-O', ',-O', 'hypertensive-O', 'therapies-O', '.-O']
['OBJECTIVE-O', ':-O', 'This-O', 'study-O', 'investigated-O', 'the-O', 'efficacy-O', 'and-O', 'tolerability-O', 'of-O', 'valsartan-B-Chemical', '(-O', 'VAL-O', ')-O', 'or-O', 'hydrochlorothiazide-B-Chemical', '(-O', 'HCTZ-O', ')-O', 'monotherapy-O', 'and-O', 'higher-O', '-O', 'dose-O', 'combinations-O', 'in-O', 'patients-O', 'with-O', 'essential-O', 'hypertension-B-Disease', '.-O']
['METHODS-O', ':-O', 'The-O', 'first-O', 'part-O', 'of-O', 'this-O', 'study-O', 'was-O', 'an-O', '8-O', ',-O', 'week-O', ',-O', 'multicenter-O', ',-O', 'randomized-O', ',-O', 'double-O', ',-O', 'blind-O', ',-O', 'placebo-O', 'controlled-O', ',-O', 'parallel-O', ',-O', 'group-O', 'trial-O', '.-O']
['Patients-O', 'with-O', 'essential-O', 'hypertension-B-Disease', '(-O', 'mean-O', 'sitting-O', 'diastolic-O', 'BP-O', '[-O', 'MSDBP-O', ']-O', '>-O', 'or-O', '=-O', '95-O', 'mm-O', 'Hg-O', 'and-O', '<-O', '110-O', 'mm-O', 'Hg-O', ')-O', 'were-O', 'randomized-O', 'to-O', '1-O', 'of-O', '8-O', 'treatment-O', 'groups-O', ':-O', 'VAL-B-Chemical', '160-O', 'or-O', '320-O', 'mg-O', ';-O', 'HCTZ-B-Chemical', '12-O', '.-O']
['5-O', 'or-O', '25-O', 'mg-O', ';-O', 'VAL-B-Chemical', '/-O', 'HCTZ-B-Chemical', '160-O', '/-O', '12-O', '.-O']
['5-O', ',-O', '320-O', '/-O', '12-O', '.-O']
['5-O', ',-O', 'or-O', '320-O', '/-O', '25-O', 'mg-O', ';-O', 'or-O', 'placebo-O', '.-O']
['Mean-O', 'changes-O', 'in-O', 'MSDBP-O', 'and-O', 'mean-O', 'sitting-O', 'systolic-O', 'BP-O', '(-O', 'MSSBP-O', ')-O', 'were-O', 'analyzed-O', 'at-O', 'the-O', '8-O', ',', 'week-O', 'core-O', 'study-O', 'end-O', 'point-O', '.-O']
['VAL-B-Chemical', '/-O', 'HCTZ-B-Chemical', '320-O', '/-O', '12-O', '.-O']
['5-O', 'and-O', '320-O', '/-O', '25-O', 'mg-O', 'were-O', 'further-O', 'investigated-O', 'in-O', 'a-O', '54-O', ',-O', 'week-O', ',-O', 'open-O', ',-O', 'label-O', 'extension-O', '.-O']
['Response-O', 'was-O', 'defined-O', 'as-O', 'MSDBP-O', '<-O', '90-O', 'mm-O', 'Hg-O', 'or-O', 'a-O', '>-O', 'or-O', '=-O', '10-O', 'mm-O', 'Hg-O', 'decrease-O', 'compared-O', 'to-O', 'baseline-O', '.-O']
['Control-O', 'was-O', 'defined-O', 'as-O', 'MSDBP-O', '<-O', '90-O', 'mm-O', 'Hg-O', 'compared-O', 'with-O', 'baseline-O', '.-O']
['Tolerability-O', 'was-O', 'assessed-O', 'by-O', 'monitoring-O', 'adverse-O', 'events-O', 'at-O', 'randomization-O', 'and-O', 'all-O', 'subsequent-O', 'study-O', 'visits-O', 'and-O', 'regular-O', 'evaluation-O', 'of-O', 'hematology-O', 'and-O', 'blood-O', 'chemistry-O', '.-O']
['RESULTS-O', ':-O', 'A-O', 'total-O', 'of-O', '1346-O', 'patients-O', 'were-O', 'randomized-O', 'into-O', 'the-O', '8-O', 'week-O', 'core-O', 'study-O', '(-O', '734-O', 'men-O', ',-O', '612-O', 'women-O', ';-O', '924-O', 'white-O', ',-O', '291-O', 'black-O', ',-O', '23-O', 'Asian-O', ',-O', '108-O', 'other-O', ';-O', 'mean-O', 'age-O', ',-O', '52-O', '.-O']
['7-O', 'years-O', ';-O', 'mean-O', 'weight-O', ',-O', '92-O', '.-O']
['6-O', 'kg-O', ').-O', 'All-O', 'active-O', 'treatments-O', 'were-O', 'associated-O', 'with-O', 'significantly-O', 'reduced-O', 'MSSBP-O', 'and-O', 'MSDBP-O', 'during-O', 'the-O', 'core-O', '8-O', 'week-O', 'study-O', ',-O', 'with-O', 'each-O', 'monotherapy-O', 'significantly-O', 'contributing-O', 'to-O', 'the-O', 'overall-O', 'effect-O', 'of-O', 'combination-O', 'therapy-O', '(-O', 'VAL-B-Chemical', 'and-O', 'HCTZ-B-Chemical', ',-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'Each-O', 'combination-O', 'was-O', 'associated-O', 'with-O', 'significantly-O', 'greater-O', 'reductions-O', 'in-O', 'MSSBP-O', 'and-O', 'MSDBP-O', 'compared-O', 'with-O', 'the-O', 'monotherapies-O', 'and-O', 'placebo-O', '(-O', 'all-O', ',-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'The-O', 'mean-O', 'reduction-O', 'in-O', 'MSSBP-O', '/-O', 'MSDBP-O', 'with-O', 'VAL-B-Chemical', '/-O', 'HCTZ-B-Chemical', '320-O', '/-O', '25-O', 'mg-O', 'was-O', '24-O', '.-O']
['7-O', '/-O', '16-O', '.-O']
['6-O', 'mm-O', 'Hg-O', ',-O', 'compared-O', 'with-O', '5-O', '.-O']
['9-O', '/-O', '7-O', '.-O']
['0-O', 'mm-O', 'Hg-O', 'with-O', 'placebo-O', '.-O']
['The-O', 'reduction-O', 'in-O', 'MSSBP-O', 'was-O', 'significantly-O', 'greater-O', 'with-O', 'VAL-B-Chemical', '/-O', 'HCTZ-B-Chemical', '320-O', '/-O', '25-O', 'mg-O', 'compared-O', 'with-O', 'VAL-B-Chemical', '/-O', 'HCTZ-B-Chemical', '160-O', '/-O', '12-O', '.-O']
['5-O', 'mg-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['002-O', ').-O', 'Rates-O', 'of-O', 'response-O', 'and-O', 'BP-O', 'control-O', 'were-O', 'significantly-O', 'higher-O', 'in-O', 'the-O', 'groups-O', 'that-O', 'received-O', 'combination-O', 'treatment-O', 'compared-O', 'with-O', 'those-O', 'that-O', 'received-O', 'monotherapy-O', '.-O']
['The-O', 'incidence-O', 'of-O', 'hypokalemia-B-Disease', 'was-O', 'lower-O', 'with-O', 'VAL-B-Chemical', '/', 'HCTZ-B-Chemical', 'combinations-O', '(-O', '1-O', '.-O']
['8-O', '%-O', '6-O', '.-O']
['1-O', ')-O', 'than-O', 'with-O', 'HCTZ-B-Chemical', 'monotherapies-O', '(-O', '7-O', '.-O']
['1-O', '%-O', '13-O', '.-O']
['3-O', ').-O', 'The-O', 'majority-O', 'of-O', 'adverse-O', 'events-O', 'in-O', 'the-O', 'core-O', 'study-O', 'were-O', 'of-O', 'mild-O', 'to-O', 'moderate-O', 'severity-O', '.-O']
['The-O', 'efficacy-O', 'and-O', 'tolerability-O', 'of-O', 'VAL-B-Chemical', '/', 'HCTZ-B-Chemical', 'combinations-O', 'were-O', 'maintained-O', 'during-O', 'the-O', 'extension-O', '(-O', '797-O', 'patients-O', ').-O', 'CONCLUSIONS-O', ':-O', 'In-O', 'this-O', 'study-O', 'population-O', ',-O', 'combination-O', 'therapies-O', 'with-O', 'VAL-B-Chemical', '/', 'HCTZ-B-Chemical', 'were-O', 'associated-O', 'with-O', 'significantly-O', 'greater-O', 'BP-O', 'reductions-O', 'compared-O', 'with-O', 'either-O', 'monotherapy-O', ',-O', 'were-O', 'well-O', 'tolerated-O', ',-O', 'and-O', 'were-O', 'associated-O', 'with-O', 'less-O', 'hypokalemia-O', 'than-O', 'HCTZ-B-Chemical']
['Succimer-B-Chemical', 'chelation-O', 'improves-O', 'learning-O', ',-O', 'attention-O', ',-O', 'and-O', 'arousal-O', 'regulation-O', 'in-O', 'lead-B-Chemical', ',-O', 'exposed-O', 'rats-O', 'but-O', 'produces-O', 'lasting-O', 'cognitive-B-Disease', 'impairment-I-Disease', 'in-O', 'the-O', 'absence-O', 'of-O', 'lead-B-Chemical', 'exposure-O', '.-O']
['BACKGROUND-O', ':-O', 'There-O', 'is-O', 'growing-O', 'pressure-O', 'for-O', 'clinicians-O', 'to-O', 'prescribe-O', 'chelation-O', 'therapy-O', 'at-O', 'only-O', 'slightly-O', 'elevated-O', 'blood-O', 'lead-B-Chemical', 'levels-O', '.-O']
['However-O', ',-O', 'very-O', 'few-O', 'studies-O', 'have-O', 'evaluated-O', 'whether-O', 'chelation-O', 'improves-O', 'cognitive-O', 'outcomes-O', 'in-O', 'Pb-B-Chemical', ',-O', 'exposed-O', 'children-O', ',-O', 'or-O', 'whether-O', 'these-O', 'agents-O', 'have-O', 'adverse-O', 'effects-O', 'that-O', 'may-O', 'affect-O', 'brain-O', 'development-O', 'in-O', 'the-O', 'absence-O', 'of-O', 'Pb-B-Chemical', 'exposure-O', '.-O']
['OBJECTIVES-O', ':-O', 'The-O', 'present-O', 'study-O', 'was-O', 'designed-O', 'to-O', 'answer-O', 'these-O', 'questions-O', ',-O', 'using-O', 'a-O', 'rodent-O', 'model-O', 'of-O', 'early-O', 'childhood-O', 'Pb-B-Chemical', 'exposure-O', 'and-O', 'treatment-O', 'with-O', 'succimer-B-Chemical', ',-O', 'a-O', 'widely-O', 'used-O', 'chelating-O', 'agent-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'Pb-B-Chemical', 'poisoning-O', '.-O']
['RESULTS-O', ':-O', 'Pb-B-Chemical', 'exposure-O', 'produced-O', 'lasting-O', 'impairments-O', 'in-O', 'learning-B-Disease', ',', 'attention-B-Disease', ',', 'inhibitory-O', 'control-O', ',', 'and-O', 'arousal-O', 'regulation-O', ',', 'paralleling-O', 'the-O', 'areas-O', 'of-O', 'dysfunction-O', 'seen-O', 'in-O', 'Pb-B-Chemical', ',', 'exposed-O', 'children-O', '.-O']
['Succimer-B-Chemical', 'treatment-O', 'of-O', 'the-O', 'Pb-B-Chemical', ',-O', 'exposed-O', 'rats-O', 'significantly-O', 'improved-O', 'learning-O', ',-O', 'attention-O', ',-O', 'and-O', 'arousal-O', 'regulation-O', ',-O', 'although-O', 'the-O', 'efficacy-O', 'of-O', 'the-O', 'treatment-O', 'varied-O', 'as-O', 'a-O', 'function-O', 'of-O', 'the-O', 'Pb-B-Chemical', 'exposure-O', 'level-O', 'and-O', 'the-O', 'specific-O', 'functional-O', 'deficit-O', '.-O']
['In-O', 'contrast-O', ',-O', 'succimer-B-Chemical', 'treatment-O', 'of-O', 'rats-O', 'not-O', 'previously-O', 'exposed-O', 'to-O', 'Pb-B-Chemical', 'produced-O', 'lasting-O', 'and-O', 'pervasive-O', 'cognitive-O', 'and-O', 'affective-O', 'dysfunction-B-Disease', 'comparable-O', 'in-O', 'magnitude-O', 'to-O', 'that-O', 'produced-O', 'by-O', 'the-O', 'higher-O', 'Pb-B-Chemical', 'exposure-O', 'regimen-O', '.-O']
['CONCLUSIONS-O', ':-O', 'These-O', 'are-O', 'the-O', 'first-O', 'data-O', ',-O', 'to-O', 'our-O', 'knowledge-O', ',-O', 'to-O', 'show-O', 'that-O', 'treatment-O', 'with-O', 'any-O', 'chelating-O', 'agent-O', 'can-O', 'alleviate-O', 'cognitive-O', 'deficits-O', 'due-O', 'to-O', 'Pb-B-Chemical', 'exposure-O', '.-O']
['These-O', 'findings-O', 'suggest-O', 'that-O', 'it-O', 'may-O', 'be-O', 'possible-O', 'to-O', 'identify-O', 'a-O', 'succimer-B-Chemical', 'treatment-O', 'protocol-O', 'that-O', 'improves-O', 'cognitive-O', 'outcomes-O', 'in-O', 'Pb-B-Chemical', ',-O', 'exposed-O', 'children-O', '.-O']
['However-O', ',-O', 'they-O', 'also-O', 'suggest-O', 'that-O', 'succimer-B-Chemical', 'treatment-O', 'should-O', 'be-O', 'strongly-O', 'discouraged-O', 'for-O', 'children-O', 'who-O', 'do-O', 'not-O', 'have-O', 'elevated-O', 'tissue-O', 'levels-O', 'of-O', 'Pb-B-Chemical']
['Caffeine-B-Chemical', 'challenge-O', 'test-O', 'in-O', 'panic-B-Disease', 'disorder-I-Disease', 'and-O', 'depression-B-Disease', 'with-O', 'panic-B-Disease', 'attacks-O', '.-O']
['Our-O', 'aim-O', 'was-O', 'to-O', 'observe-O', 'if-O', 'patients-O', 'with-O', 'panic-B-Disease', 'disorder-I-Disease', '(-O', 'PD-O', ')-O', 'and-O', 'patients-O', 'with-O', 'major-B-Disease', 'depression-I-Disease', 'with-O', 'panic-B-Disease', 'attacks-O', '(-O', 'MDP-O', ')-O', '(-O', 'Diagnostic-O', 'and-O', 'Statistical-O', 'Manual-O', 'of-O', 'Mental-O', 'Disorders-O', ',-O', 'Fourth-O', 'Edition-O', 'criteria-O', ')-O', 'respond-O', 'in-O', 'a-O', 'similar-O', 'way-O', 'to-O', 'the-O', 'induction-O', 'of-O', 'panic-B-Disease', 'attacks-O', 'by-O', 'an-O', 'oral-O', 'caffeine-B-Chemical', 'challenge-O', 'test-O', '.-O']
['We-O', 'randomly-O', 'selected-O', '29-O', 'patients-O', 'with-O', 'PD-B-Disease', ',-O', '27-O', 'with-O', 'MDP-B-Disease', ',-O', '25-O', 'with-O', 'major-B-Disease', 'depression-I-Disease', 'without-O', 'panic-B-Disease', 'attacks-O', '(-O', 'MD-B-Disease', ')-O', 'and-O', '28-O', 'healthy-O', 'volunteers-O', '.-O']
['The-O', 'patients-O', 'had-O', 'no-O', 'psychotropic-O', 'drug-O', 'for-O', 'at-O', 'least-O', 'a-O', '4-O', ',', 'week-O', 'period-O', '.-O']
['In-O', 'a-O', 'randomized-O', 'double-O', ',-O', 'blind-O', 'experiment-O', 'performed-O', 'in-O', '2-O', 'occasions-O', '7-O', 'days-O', 'apart-O', ',-O', '480-O', 'mg-O', 'caffeine-B-Chemical', 'and-O', 'a-O', 'caffeine-B-Chemical', ',-O', 'free-O', '(-O', 'placebo-O', ')-O', 'solution-O', 'were-O', 'administered-O', 'in-O', 'a-O', 'coffee-O', 'form-O', 'and-O', 'anxiety-B-Disease', 'scales-O', 'were-O', 'applied-O', 'before-O', 'and-O', 'after-O', 'each-O', 'test-O', '.-O']
['A-O', 'total-O', 'of-O', '58-O', '.-O']
['6-O', '(-O', 'n-O', '='-O', '17-O', ')-O', 'of-O', 'patients-O', 'with-O', 'PD-B-Disease', ',-O', '44-O', '.-O']
['4-O', '(-O', 'n-O', '=-O', '12-O', ')-O', 'of-O', 'patients-O', 'with-O', 'MDP-B-Disease', ',-O', '12-O', '.-O']
['0-O', '(-O', 'n-O', '=O', '3-O', ')-O', 'of-O', 'patients-O', 'with-O', 'MD-B-Disease', ',-O', 'and-O', '7-O', '.-O']
['1-O', '(-O', 'n-O', '=O', '2-O', ')-O', 'of-O', 'control-O', 'subjects-O', 'had-O', 'a-O', 'panic-B-Disease', 'attack-O', 'after-O', 'the-O', '480-O', ',', 'mg-O', 'caffeine-B-Chemical', 'challenge-O', 'test-O', '(-O', 'chi-O', '(-O', '2-O', ')-O', '3-O', ')-O', '16-O', '.-O']
['22-O', ',-O', 'P-O', '=-O', '.-O', '001-O', ')-O', 'The-O', 'patients-O', 'with-O', 'PD-B-Disease', 'and-O', 'MDP-B-Disease', 'were-O', 'more-O', 'sensitive-O', 'to-O', 'caffeine-B-Chemical', 'than-O', 'were-O', 'patients-O', 'with-O', 'MD-B-Disease', 'and-O', 'healthy-O', 'volunteers-O', '.-O']
['No-O', 'panic-B-Disease', 'attack-O', 'was-O', 'observed-O', 'after-O', 'the-O', 'caffeine-B-Chemical', ',-O', 'free-O', 'solution-O', 'intake-O', '.-O']
['The-O', 'patients-O', 'with-O', 'MD-B-Disease', 'had-O', 'a-O', 'lower-O', 'heart-O', 'rate-O', 'response-O', 'to-O', 'the-O', 'test-O', 'than-O', 'all-O', 'the-O', 'other-O', 'groups-O', '(-O', '2-O', '-O', 'way-O', 'analysis-O', 'of-O', 'variance-O', '-O', 'group-O', 'by-O', 'time-O', 'interaction-O', 'with-O', 'Greenhouse-O', '-O', 'Geisser-O', 'correction-O', ':-O', 'F-O', '(-O', '3-O', '-O', '762-O', ')', '2-O', '.-O']
['85-O', ',-O', 'P-O', '=.-O', '026-O', ')-O', '.-O', 'Our-O', 'data-O', 'suggest-O', 'that-O', 'there-O', 'is-O', 'an-O', 'association-O', 'between-O', 'panic-B-Disease', 'attacks-O', ',-O', 'no-O', 'matter-O', 'if-O', 'associated-O', 'with-O', 'PD-O', 'or-O', 'MDP-O', ',-O', 'and-O', 'hyperreactivity-O', 'to-O', 'an-O', 'oral-O', 'caffeine-B-Chemical']
['Mitral-O', 'annuloplasty-O', 'as-O', 'a-O', 'ventricular-O', 'restoration-O', 'method-O', 'for-O', 'the-O', 'failing-O', 'left-O', 'ventricle-O', ':-O', 'a-O', 'pilot-O', 'study-O', '.-O']
['BACKGROUND-O', 'AND-O', 'AIM-O', 'OF-O', 'THE-O', 'STUDY-O', ':-O', 'Undersized-O', 'mitral-O', 'annuloplasty-O', '(-O', 'MAP-O', ')-O', 'is-O', 'effective-O', 'in-O', 'patients-O', 'with-O', 'dilated-B-Disease', 'cardiomyopathy-I-Disease', 'and-O', 'functional-O', 'mitral-O', 'regurgitation-I-Disease', '(-O', 'MR-B-Disease', ')-O', 'since-O', ',-O', 'as-O', 'well-O', 'as-O', 'addressing-O', 'the-O', 'MR-O', ',-O', 'the-O', 'MAP-O', 'may-O', 'also-O', 'reshape-O', 'the-O', 'dilated-B-Disease', 'left-O', 'ventricular-O', '(-O', 'LV-O', ')-O', 'base-O', '.-O']
['However-O', ',-O', 'the-O', 'direct-O', 'benefits-O', 'of-O', 'this-O', 'possible-O', 'reshaping-O', 'on-O', 'LV-O', 'function-O', 'in-O', 'the-O', 'absence-O', 'of-O', 'underlying-O', 'MR-B-Disease', 'remain-O', 'incompletely-O', 'understood-O', '.-O']
['The-O', 'study-O', 'aim-O', 'was-O', 'to-O', 'identify-O', 'these-O', 'benefits-O', 'in-O', 'a-O', 'canine-O', 'model-O', 'of-O', 'acute-B-Disease', 'heart-B-Disease', 'failure-I-Disease', '.-O']
['METHODS-O', ':-O', 'Six-O', 'dogs-O', 'underwent-O', 'MAP-O', 'with-O', 'a-O', 'prosthetic-O', 'band-O', 'on-O', 'the-O', 'posterior-O', 'mitral-O', 'annulus-O', ',-O', 'using-O', 'four-O', 'mattress-O', 'sutures-O', '.-O']
['The-O', 'sutures-O', 'were-O', 'passed-O', 'individually-O', 'through-O', 'four-O', 'tourniquets-O', 'and-O', 'exteriorized-O', 'untied-O', 'via-O', 'the-O', 'left-O', 'atriotomy-O', '.-O']
['Sonomicrometry-O', 'crystals-O', 'were-O', 'implanted-O', 'around-O', 'the-O', 'mitral-O', 'annulus-O', 'and-O', 'left-O', 'ventricle-O', 'to-O', 'measure-O', 'geometry-O', 'and-O', 'regional-O', 'function-O', '.-O']
['Acute-B-Disease', 'heart-B-Disease', 'failure-I-Disease', 'was-O', 'induced-O', 'by-O', 'propranolol-B-Chemical', 'and-O', 'volume-O', 'loading-O', 'after-O', 'weaning-O', 'from-O', 'cardiopulmonary-O', 'bypass-O', ';-O', 'an-O', 'absence-O', 'of-O', 'MR-O', 'was-O', 'confirmed-O', 'by-O', 'echocardiography-O', '.-O']
['MAP-O', 'was-O', 'accomplished-O', 'by-O', 'cinching-O', 'the-O', 'tourniquets-O', '.-O']
['Data-O', 'were-O', 'acquired-O', 'at-O', 'baseline-O', ',-O', 'after-O', 'induction-O', 'of-O', 'acute-B-Disease', 'heart-B-Disease', 'failure-I-Disease', ',-O', 'and-O', 'after-O', 'MAP-O', '.-O']
['RESULTS-O', ':-O', 'MAP-O', 'decreased-O', 'mitral-B-Disease', 'annular-O', 'dimensions-O', 'in-O', 'both-O', 'commissure-O', ',-O', 'commissure-O', 'and-O', 'septal-I-Disease', ',-O', 'lateral-O', 'directions-O', '.-O']
['Concomitantly-O', ',-O', 'the-O', 'diastolic-O', 'diameter-O', 'of-O', 'the-O', 'LV-O', 'base-O', 'and-O', 'LV-O', 'sphericity-O', 'decreased-O', '(-O', 'i-O', '.-O']
['e-O', '.-O', 'improved-O', ')-O', 'from-O', '37-O', '.-O']
['4-O', '+-O', '9-O', '.-O']
['3-O', 'to-O', '35-O', '.-O']
['9-O', '+-O', '10-O', 'mm-O', '(-O', 'p-O', '=-O', '0-O', '.-O']
['063-O', ')-O', 'and-O', 'from-O', '67-O', '.-O']
['9-O', '+-O', '18-O', '.-O']
['6-O', '%-O', 'to-O', '65-O', '.-O']
['3-O', '+-O', '18-O', '.-O']
['9-O', '(-O', 'p-O', '=', '0-O', '.-O']
['016-O', ',-O', 'respectively-O', '.-O']
['Decreases-O', 'were-O', 'evident-O', 'in-O', 'both-O', 'LV-O', 'end-O', ',-O', 'diastolic-O', 'pressure-O', '(-O', 'from-O', '17-O', '+-O', '7-O', 'to-O', '15-O', '+-O', '6-O', 'mmHg-O', ',-O', 'p-O', '=-O', '0-O', '.-O']
['0480-O', 'and-O', 'Tau-O', '(-O', 'from-O', '48-O', '+-O', '8-O', 'to-O', '45-O', '+-O', '8-O', 'ms-O', ',-O', 'p-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'while-O', 'fractional-O', 'shortening-O', 'at-O', 'the-O', 'LV-O', 'base-O', 'increased-O', 'from-O', '7-O', '.-O']
['7-O', '+-O', '4-O', '.-O']
['5-O', '%-O', 'to-O', '9-O', '.-O']
['4-O', '+-O', '4-O', '.-O']
['5-O', '(-O', 'p-O', '=', '0-O', '.-O']
['045-O', ').-O', 'After-O', 'MAP-O', ',-O', 'increases-O', 'were-O', 'identified-O', 'in-O', 'both-O', 'cardiac-O', 'output-O', '(-O', 'from-O', '1-O', '.-O']
['54-O', '+-O', '0-O', '.-O']
['57-O', 'to-O', '1-O', '.-O']
['65-O', '+-O', '0-O', '.-O']
['57-O', '1-O', '/-O', 'min-O', ')-O', 'and-O', 'Emax-O', '(-O', 'from-O', '1-O', '.-O']
['86-O', '+-O', '0-O', '.-O']
['9-O', 'to-O', '2-O', '.-O']
['41-O', '+-O', '1-O', '.-O']
['31-O', 'mmHg-O', '/-O', 'ml-O', ').-O', 'CONCLUSION-O', ':-O', 'The-O', 'data-O', 'acquired-O', 'suggest-O', 'that-O', 'isolated-O', 'MAP-O', 'may-O', 'have-O', 'certain-O', 'benefits-O', 'on-O', 'LV-O', 'dimension-O', '/-O', 'function-O', 'in-O', 'acute-O', 'heart-B-Disease', 'failure-I-Disease', ',-O', 'even-O', 'in-O', 'the-O', 'absence-O', 'of-O', 'MR-O', '.-O']
['However-O', ',-O', 'further-O', 'investigations-O', 'are-O', 'warranted-O', 'in-O', 'a-O', 'model-O', 'of-O', 'chronic-B-Disease', 'heart-B-Disease', 'failure-I-Disease']
['Piperacillin/tazobactam-B-Chemical', ',-O', 'induced-O', 'seizure-B-Disease', 'rapidly-O', 'reversed-O', 'by-O', 'high-O', 'flux-O', 'hemodialysis-O', 'in-O', 'a-O', 'patient-O', 'on-O', 'peritoneal-O', 'dialysis-O', '.-O']
['Despite-O', 'popular-O', 'use-O', 'of-O', 'piperacillin-B-Chemical', ',-O', 'the-O', 'dire-O', 'neurotoxicity-B-Disease', 'associated-O', 'with-O', 'piperacillin-B-Chemical', 'still-O', 'goes-O', 'unrecognized-O', ',-O', 'leading-O', 'to-O', 'a-O', 'delay-O', 'in-O', 'appropriate-O', 'management-O', '.-O']
['We-O', 'report-O', 'a-O', '57-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'with-O', 'end-stage-B-Disease', 'renal-I-Disease', 'disease-I-Disease', 'receiving-O', 'continuous-O', 'ambulatory-O', 'peritoneal-O', 'dialysis-O', '(-O', 'CAPD-O', ')-O', 'who-O', 'developed-O', 'slurred-O', 'speech-O', ',-O', 'tremor-B-Disease', ',-O', 'bizarre-O', 'behavior-O', ',-O', 'progressive-O', 'mental-O', 'confusion-B-Disease', ',-O', 'and-O', '2-O', 'episodes-O', 'of-O', 'generalized-B-Disease', 'tonic-clonic-B-Disease', 'seizure-I-Disease', '(-O', 'GTCS-B-Disease', ')-O', 'after-O', '5-O', 'doses-O', 'of-O', 'piperacillin/tazobactam-B-Chemical', '(-O', '2-O', 'g-O', '/-O', '250-O', 'mg-O', ')-O', 'were-O', 'given-O', 'for-O', 'bronchiectasis-B-Disease', 'with-O', 'secondary-O', 'infection-O', '.-O']
['The-O', 'laboratory-O', 'data-O', 'revealed-O', 'normal-O', 'plasma-O', 'electrolyte-O', 'and-O', 'ammonia-B-Chemical', 'levels-O', 'but-O', 'leukocytosis-B-Disease', '.-O']
['Neurologic-O', 'examinations-O', 'showed-O', 'dysarthria-B-Disease', 'and-O', 'bilateral-O', 'Babinski-B-Disease', 'sign-O', '.-O']
['Computed-O', 'tomography-O', 'of-O', 'brain-O', 'and-O', 'electroencephalogram-O', 'were-O', 'unremarkable-O', '.-O']
['Despite-O', 'the-O', 'use-O', 'of-O', 'antiepileptic-O', 'agents-O', ',-O', 'another-O', 'GTCS-B-Disease', 'episode-O', 'recurred-O', 'after-O', 'the-O', 'sixth-O', 'dose-O', 'of-O', 'piperacillin/tazobactam-B-Chemical', '.-O']
['Brain-O', 'magnetic-O', 'resonance-O', 'imaging-O', 'did-O', 'not-O', 'demonstrate-O', 'acute-O', 'infarction-B-Disease', 'and-O', 'organic-O', 'brain-O', 'lesions-B-Disease', '.-O']
['Initiation-O', 'of-O', 'high-O', ',-O', 'flux-O', 'hemodialysis-O', 'rapidly-O', 'reversed-O', 'the-O', 'neurologic-O', 'symptoms-I-Disease', 'within-O', '4-O', 'hours-O', '.-O']
['Piperacillin-B-Chemical', ',-O', 'induced-O', 'encephalopathy-B-Disease', 'should-O', 'be-O', 'considered-O', 'in-O', 'any-O', 'uremic-B-Disease', 'patients-O', 'with-O', 'unexplained-O', 'neurological-B-Disease', 'manifestations-O', '.-O']
['CAPD-O', 'is-O', 'inefficient-O', 'in-O', 'removing-O', 'piperacillin-B-Chemical', ',-O', 'whereas-O', 'hemodialysis-O', 'can-O', 'rapidly-O', 'terminate-O', 'the-O', 'piperacillin-B-Chemical', ',-O', 'induced-O', 'encephalopathy-B-Disease']
['Frequency-O', 'of-O', 'transient-B-Disease', 'ipsilateral-I-Disease', 'vocal-O', 'cord-O', 'paralysis-I-Disease', 'in-O', 'patients-O', 'undergoing-O', 'carotid-O', 'endarterectomy-O', 'under-O', 'local-O', 'anesthesia-O', '.-O']
['BACKGROUND-O', ':-O', 'Especially-O', 'because-O', 'of-O', 'improvements-O', 'in-O', 'clinical-O', 'neurologic-B-Disease', 'monitoring-O', ',-O', 'carotid-O', 'endarterectomy-O', 'done-O', 'under-O', 'local-O', 'anesthesia-O', 'has-O', 'become-O', 'the-O', 'technique-O', 'of-O', 'choice-O', 'in-O', 'several-O', 'centers-O', '.-O']
['Temporary-O', 'ipsilateral-O', 'vocal-O', 'nerve-O', 'palsies-B-Disease', 'due-O', 'to-O', 'local-O', 'anesthetics-O', 'have-O', 'been-O', 'described-O', ',-O', 'however-O', '.-O']
['Such-O', 'complications-O', 'are-O', 'most-O', 'important-O', 'in-O', 'situations-O', 'where-O', 'there-O', 'is-O', 'a-O', 'pre-O', ',-O', 'existing-O', 'contralateral-O', 'paralysis-B-Disease', '.-O']
['We-O', 'therefore-O', 'examined-O', 'the-O', 'effect-O', 'of-O', 'local-O', 'anesthesia-O', 'on-O', 'vocal-O', 'cord-O', 'function-O', 'to-O', 'better-O', 'understand-O', 'its-O', 'possible-O', 'consequences-O', '.-O']
['METHODS-O', ':-O', 'This-O', 'prospective-O', 'study-O', 'included-O', '28-O', 'patients-O', 'undergoing-O', 'carotid-O', 'endarterectomy-O', 'under-O', 'local-O', 'anesthesia-O', '.-O']
['Vocal-O', 'cord-O', 'function-O', 'was-O', 'evaluated-O', 'before-O', ',-O', 'during-O', ',-O', 'and-O', 'after-O', 'surgery-O', '(-O', 'postoperative-O', 'day-O', '1-O', ')-O', 'using-O', 'flexible-O', 'laryngoscopy-O', '.-O']
['Anesthesia-O', 'was-O', 'performed-O', 'by-O', 'injecting-O', '20-O', 'to-O', '40-O', 'mL-O', 'of-O', 'a-O', 'mixture-O', 'of-O', 'long-O', ',-O', 'acting-O', '(-O', 'ropivacaine-B-Chemical', ')-O', 'and-O', 'short-O', ',-O', 'acting-O', '(-O', 'prilocaine-B-Chemical', ')-O', 'anesthetic-O', '.-O']
['RESULTS-O', ':-O', 'All-O', 'patients-O', 'had-O', 'normal-O', 'vocal-O', 'cord-O', 'function-O', 'preoperatively-O', '.-O']
['Twelve-O', 'patients-O', '(-O', '43-O', ')-O', 'were-O', 'found-O', 'to-O', 'have-O', 'intraoperative-O', 'ipsilateral-O', 'vocal-O', 'cord-B-Disease', 'paralysis-I-Disease', '.-O']
['It-O', 'resolved-O', 'in-O', 'all-O', 'cases-O', '<-O', 'or-O', '='-O', '24-O', 'hours-O', '.-O']
['There-O', 'were-O', 'no-O', 'significant-O', 'differences-O', 'in-O', 'operating-O', 'time-O', 'or-O', 'volume-O', 'or-O', 'frequency-O', 'of-O', 'anesthetic-O', 'administration-O', 'in-O', 'patients-O', 'with-O', 'temporary-O', 'vocal-O', 'cord-B-Disease', 'paralysis-I-Disease', 'compared-O', 'with-O', 'those-O', 'without-O', '.-O']
['CONCLUSION-O', ':-O', 'Local-O', 'anesthesia-O', 'led-O', 'to-O', 'temporary-O', 'ipsilateral-O', 'vocal-O', 'cord-B-Disease', 'paralysis-I-Disease', 'in-O', 'almost-O', 'half-O', 'of-O', 'these-O', 'patients-O', '.-O']
['Because-O', 'pre-O', ',-O', 'existing-O', 'paralysis-B-Disease', 'is-O', 'of-O', 'a-O', 'relevant-O', 'frequency-O', '(-O', 'up-O', 'to-O', '3-O', '),', 'a-O', 'preoperative-O', 'evaluation-O', 'of-O', 'vocal-O', 'cord-O', 'function-O', 'before-O', 'carotid-O', 'endarterectomy-O', 'under-O', 'local-O', 'anesthesia-O', 'is-O', 'recommended-O', 'to-O', 'avoid-O', 'intraoperative-O', 'bilateral-O', 'paralysis-B-Disease', '.-O']
['In-O', 'patients-O', 'with-O', 'preoperative-O', 'contralateral-O', 'vocal-O', 'cord-B-Disease', 'paralysis-I-Disease']
['Neuroprotective-O', 'effects-O', 'of-O', 'melatonin-B-Chemical', 'upon-O', 'the-O', 'offspring-O', 'cerebellar-O', 'cortex-O', 'in-O', 'the-O', 'rat-O', 'model-O', 'of-O', 'BCNU-B-Chemical', ',-O', 'induced-O', 'cortical-O', 'dysplasia-B-Disease', '.-O']
['Cortical-B-Disease', 'dysplasia-I-Disease', 'is-O', 'a-O', 'malformation-O', 'characterized-O', 'by-O', 'defects-O', 'in-O', 'proliferation-O', ',-O', 'migration-O', 'and-O', 'maturation-O', '.-O']
['This-O', 'study-O', 'was-O', 'designed-O', 'to-O', 'evaluate-O', 'the-O', 'alterations-O', 'in-O', 'offspring-O', 'rat-O', 'cerebellum-O', 'induced-O', 'by-O', 'maternal-O', 'exposure-O', 'to-O', 'carmustine-B-Chemical', '-[O', '1,3-bis-O', '(2-chloroethyl)-1-nitrosoure-O', '](-O', 'BCNU-B-Chemical', ')-O', 'and-O', 'to-O', 'investigate-O', 'the-O', 'effects-O', 'of-O', 'exogenous-O', 'melatonin-B-Chemical', 'upon-O', 'cerebellar-O', 'BCNU-B-Chemical', '-O', 'induced-O', 'cortical-O', 'dysplasia-B-Disease', ',-O', 'using-O', 'histological-O', 'and-O', 'biochemical-O', 'analyses-O', '.-O']
['Pregnant-O', 'Wistar-O', 'rats-O', 'were-O', 'assigned-O', 'to-O', 'five-O', 'groups-O', ':-O', 'intact-O', ',-O', 'control-O', ',-O', 'saline-O', ',-O', 'control-O', ',-O', 'melatonin-B-Chemical', ',-O', 'treated-O', ',-O', 'BCNU-B-Chemical', ',-O', 'exposed-O', 'and-O', 'BCNU-B-Chemical', ',-O', 'exposed-O', 'plus-O', 'melatonin-B-Chemical', '.-O']
['Rats-O', 'were-O', 'exposed-O', 'to-O', 'BCNU-B-Chemical', 'on-O', 'embryonic-O', 'day-O', '15-O', 'and-O', 'melatonin-B-Chemical', 'was-O', 'given-O', 'until-O', 'delivery-O', '.-O']
['Immuno-O', '/', 'histochemistry-O', 'and-O', 'electron-O', 'microscopy-O', 'were-O', 'carried-O', 'out-O', 'on-O', 'the-O', 'offspring-O', 'cerebellum-O', ',-O', 'and-O', 'levels-O', 'of-O', 'malondialdehyde-B-Chemical', 'and-O', 'superoxide-B-Chemical', 'dismutase-O', 'were-O', 'determined-O', '.-O']
['Histopathologically-O', ',', 'typical-O', 'findings-O', 'were-O', 'observed-O', 'in-O', 'the-O', 'cerebella-O', 'from-O', 'the-O', 'control-O', 'groups-O', ',', 'but-O', 'the-O', 'findings-O', 'consistent-O', 'with-O', 'early-O', 'embryonic-O', 'development-O', 'were-O', 'noted-O', 'in-O', 'BCNU-B-Chemical', ',', 'exposed-O', 'cortical-O', 'dysplasia-B-Disease', 'group-O', '.-O']
['There-O', 'was-O', 'a-O', 'marked-O', 'increase-O', 'in-O', 'the-O', 'number-O', 'of-O', 'TUNEL-O', 'positive-O', 'cells-O', 'and-O', 'nestin-O', 'positive-O', 'cells-O', 'in-O', 'BCNU-B-Chemical', ',-O', 'exposed-O', 'group-O', ',-O', 'but-O', 'a-O', 'decreased-O', 'immunoreactivity-O', 'to-O', 'glial-O', 'fibrillary-O', 'acidic-O', 'protein-O', ',-O', 'synaptophysin-O', 'and-O', 'transforming-O', 'growth-O', 'factor-O', 'beta1-O', 'was-O', 'observed-O', ',-O', 'indicating-O', 'a-O', 'delayed-O', 'maturation-O', ',-O', 'and-O', 'melatonin-B-Chemical', 'significantly-O', 'reversed-O', 'these-O', 'changes-O', '.-O']
['Malondialdehyde-B-Chemical', 'level-O', 'in-O', 'BCNU-B-Chemical', ',-O', 'exposed-O', 'group-O', 'was-O', 'higher-O', 'than-O', 'those-O', 'in-O', 'control-O', 'groups-O', 'and-O', 'melatonin-B-Chemical', 'decreased-O', 'malondialdehyde-B-Chemical', 'levels-O', 'in-O', 'BCNU-B-Chemical', 'group-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ')-O', 'while-O', 'there-O', 'were-O', 'no-O', 'significant-O', 'differences-O', 'in-O', 'the-O', 'superoxide-B-Chemical', 'dismutase-O', 'levels-O', 'between-O', 'these-O', 'groups-O', '.-O']
['These-O', 'data-O', 'suggest-O', 'that-O', 'exposure-O', 'of-O', 'animals-O', 'to-O', 'BCNU-B-Chemical', 'during-O', 'pregnancy-O', 'leads-O', 'to-O', 'delayed-O', 'maturation-O', 'of-O', 'offspring-O', 'cerebellum-O', 'and-O', 'melatonin-B-Chemical', 'protects-O', 'the-O', 'cerebellum-O', 'against-O', 'the-O', 'effects-O', 'of-O', 'BCNU-B-Chemical']
['Myo-inositol-1-phosphate-B-Chemical', '(-O', 'MIP-O', ')-O', 'synthase-O', 'inhibition-O', ':-O', 'in-O', ',-O', 'vivo-O', 'study-O', 'in-O', 'rats-O', '.-O']
['Lithium-B-Chemical', 'and-O', 'valproate-B-Chemical', 'are-O', 'the-O', 'prototypic-O', 'mood-O', 'stabilizers-O', 'and-O', 'have-O', 'diverse-O', 'structures-O', 'and-O', 'targets-O', '.-O']
['Both-O', 'drugs-O', 'influence-O', 'inositol-B-Chemical', 'metabolism-O', '.-O']
['Lithium-B-Chemical', 'inhibits-O', 'IMPase-O', 'and-O', 'valproate-B-Chemical', 'inhibits-O', 'MIP-B-Chemical', 'synthase-O', '.-O']
['This-O', 'study-O', 'shows-O', 'that-O', 'MIP-O', 'synthase-O', 'inhibition-O', 'does-O', 'not-O', 'replicate-O', 'or-O', 'augment-O', 'the-O', 'effects-O', 'of-O', 'lithium-B-Chemical', 'in-O', 'the-O', 'inositol-B-Chemical', 'sensitive-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'seizures-B-Disease', 'model-O', '.-O']
['This-O', 'lack-O', 'of-O', 'effects-O', 'may-O', 'stem-O', 'from-O', 'the-O', 'low-O', 'contribution-O', 'of-O', 'de-O', ',', 'novo-O', 'synthesis-O', 'to-O', 'cellular-O', 'inositol-B-Chemical', 'supply-O', 'or-O', 'to-O', 'the-O', 'inhibition-O', 'of-O', 'the-O', 'de-O', ',', 'novo-O', 'synthesis-O', 'by-O', 'lithium-B-Chemical']
['Non-O', ',-O', 'steroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'drugs-O', ',-O', 'associated-O', 'acute-O', 'interstitial-B-Disease', 'nephritis-I-Disease', 'with-O', 'granular-O', 'tubular-O', 'basement-O', 'membrane-O', 'deposits-O', '.-O']
['Acute-O', 'tubulo-interstitial-B-Disease', 'nephritis-I-Disease', '(-O', 'ATIN-B-Disease', ')-O', 'is-O', 'an-O', 'important-O', 'cause-O', 'of-O', 'acute-O', 'renal-B-Disease', 'failure-I-Disease', 'resulting-O', 'from-O', 'a-O', 'variety-O', 'of-O', 'insults-O', ',-O', 'including-O', 'immune-O', 'complex-O', ',-O', 'mediated-O', 'tubulo-interstitial-O', 'injury-O', ',-O', 'but-O', 'drugs-O', 'such-O', 'as-O', 'non-O', ',-O', 'steroidal-O', 'anti-O', ',-O', 'inflammatory-O', 'drugs-O', '(-O', 'NSAIDs-B-Chemical', ')-O', 'are-O', 'a-O', 'far-O', 'more-O', 'frequent-O', 'cause-O', '.-O']
['Overall-O', ',-O', 'as-O', 'an-O', 'entity-O', ',-O', 'ATIN-B-Disease', 'remains-O', 'under-O', ',-O', 'diagnosed-O', ',-O', 'as-O', 'symptoms-O', 'resolve-O', 'spontaneously-O', 'if-O', 'the-O', 'medication-O', 'is-O', 'stopped-O', '.-O']
['We-O', 'report-O', 'on-O', 'a-O', '14-O', ',-O', 'year-O', ',-O', 'old-O', 'boy-O', 'who-O', 'developed-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', '2-O', 'weeks-O', 'after-O', 'aortic-O', 'valve-O', 'surgery-O', '.-O']
['He-O', 'was-O', 'put-O', 'on-O', 'aspirin-B-Chemical', 'following-O', 'surgery-O', 'and-O', 'took-O', 'ibuprofen-B-Chemical', 'for-O', 'fever-I-Disease', 'for-O', 'nearly-O', 'a-O', 'week-O', 'prior-O', 'to-O', 'presentation-O', '.-O']
['He-O', 'then-O', 'presented-O', 'to-O', 'the-O', 'emergency-O', 'department-O', 'feeling-O', 'quite-O', 'ill-O', 'and-O', 'was-O', 'found-O', 'to-O', 'have-O', 'a-O', 'blood-B-Chemical', 'urea-B-Chemical', 'nitrogen-B-Chemical', '(-O', 'BUN-O', ')', 'concentration-O', 'of-O', 'of-O', '147-O', 'mg-O', '/-O', 'dl-O', ',-O', 'creatinine-B-Chemical', 'of-O', '15-O', '.-O']
['3-O', 'mg-O', '/-O', 'dl-O', 'and-O', 'serum-O', 'potassium-B-Chemical', 'of-O', '8-O', '.-O']
['7-O', 'mEq-O', '/-O', 'l-O', '.-O']
['Dialysis-O', 'was-O', 'immediately-O', 'initiated-O', '.-O']
['A-O', 'kidney-O', 'biopsy-O', 'showed-O', 'inflammatory-O', 'infiltrate-O', 'consistent-O', 'with-O', 'ATIN-B-Disease', '.-O']
['However-O', ',-O', 'in-O', 'the-O', 'tubular-O', 'basement-O', 'membrane-O', '(-O', 'TBM-O', ')-O', 'very-O', 'intense-O', 'granular-O', 'deposits-O', 'of-O', 'polyclonal-O', 'IgG-B-Chemical', 'and-O', 'C3-B-Chemical', 'were-O', 'noted-O', '.-O']
['He-O', 'needed-O', 'dialysis-O', 'for-O', '2-O', 'weeks-O', 'and-O', 'was-O', 'treated-O', 'successfully-O', 'with-O', 'steroids-B-Chemical', 'for-O', '6-O', 'months-O', '.-O']
['His-O', 'renal-O', 'recovery-O', 'and-O', 'disappearance-O', 'of-O', 'proteinuria-B-Disease', 'took-O', 'a-O', 'year-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'this-O', 'is-O', 'a-O', 'first-O', 'report-O', 'of-O', 'NSAIDs-B-Chemical', ',-O', 'associated-O', 'ATIN-B-Disease']
['Rifampicin-B-Chemical', ',-O', 'associated-O', 'segmental-O', 'necrotizing-O', 'glomerulonephritis-B-Disease', 'in-O', 'staphylococcal-O', 'endocarditis-B-Disease', '.-O']
['Segmental-O', 'necrotising-O', 'glomerulonephritis-B-Disease', 'has-O', 'been-O', 'reported-O', 'as-O', 'complication-O', 'of-O', 'rifampicin-B-Chemical', 'therapy-O', 'in-O', 'patients-O', 'receiving-O', 'treatment-O', 'for-O', 'tuberculosis-B-Disease', '.-O']
['Changing-O', 'epidemiology-O', 'of-O', 'infections-B-Disease', 'such-O', 'as-O', 'infective-B-Disease', 'endocarditis-I-Disease', '(-O', 'IE-O', ')-O', 'has-O', 'led-O', 'to-O', 'an-O', 'increase-O', 'in-O', 'the-O', 'use-O', 'of-O', 'rifampicin-B-Chemical', 'for-O', 'Staphylococcal-O', 'infections-B-Disease', '.-O']
['We-O', 'describe-O', 'a-O', 'case-O', 'of-O', 'a-O', 'patient-O', 'with-O', 'Staphylococcal-B-Disease', 'IE-B-Disease', 'who-O', 'developed-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'secondary-O', 'to-O', 'a-O', 'segmental-B-Disease', 'necrotising-B-Disease', 'glomerulonephritis-I-Disease', 'while-O', 'being-O', 'treated-O', 'with-O', 'rifampicin-B-Chemical', ',-O', 'and-O', 'review-O', 'the-O', 'literature-O', 'regarding-O', 'this-O', 'complication-O', 'of-O', 'rifampicin-B-Chemical']
['Rate-O', 'of-O', 'YMDD-O', 'motif-O', 'mutants-O', 'in-O', 'lamivudine-B-Chemical', ',-O', 'untreated-O', 'Iranian-O', 'patients-O', 'with-O', 'chronic-O', 'hepatitis-B-Disease', 'B-I-Disease', 'virus-I-Disease', 'infection-I-Disease', '.-O']
['BACKGROUND-O', ':-O', 'Lamivudine-B-Chemical', 'is-O', 'used-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'chronic-O', 'hepatitis-B-Disease', 'B-I-Disease', 'patients-O', '.-O']
['Recent-O', 'studies-O', 'show-O', 'that-O', 'the-O', 'YMDD-O', 'motif-O', 'mutants-O', '(-O', 'resistant-O', 'hepatitis-B-Disease', 'B-I-Disease', 'virus-I-Disease', ')-O', 'occur-O', 'as-O', 'natural-O', 'genome-O', 'variability-O', 'in-O', 'lamivudine-B-Chemical', ',-O', 'untreated-O', 'chronic-O', 'hepatitis-B-Disease', 'B-I-Disease', 'patients-O', '.-O']
['In-O', 'this-O', 'study-O', 'we-O', 'aimed-O', 'to-O', 'determine-O', 'the-O', 'rate-O', 'of-O', 'YMDD-O', 'motif-O', 'mutants-O', 'in-O', 'lamivudine-B-Chemical', ',-O', 'untreated-O', 'chronic-O', 'hepatitis-B-Disease', 'B-I-Disease', 'patients-O', 'in-O', 'Iran-O', '.-O']
['PATIENTS-O', 'AND-O', 'METHODS-O', ':-O', 'A-O', 'total-O', 'of-O', '77-O', 'chronic-B-Disease', 'hepatitis-I-Disease', 'B-I-Disease', 'patients-O', 'who-O', 'had-O', 'not-O', 'been-O', 'treated-O', 'with-O', 'lamivudine-B-Chemical', 'were-O', 'included-O', 'in-O', 'the-O', 'study-O', '.-O']
['Serum-O', 'samples-O', 'from-O', 'patients-O', 'were-O', 'tested-O', 'by-O', 'polymerase-O', 'chain-O', 'reaction-O', ',-O', 'restriction-O', 'fragment-O', 'length-O', 'polymorphism-O', '(-O', 'PCR-O', ',-O', 'RFLP-O', ')-O', 'for-O', 'detection-O', 'of-O', 'YMDD-B-Chemical', 'motif-O', 'mutants-O', '.-O']
['All-O', 'patients-O', 'were-O', 'also-O', 'tested-O', 'for-O', 'liver-O', 'enzymes-O', ',-O', 'anti-O', ',-O', 'HCV-B-Chemical', ',-O', 'HBeAg-B-Chemical', ',-O', 'and-O', 'anti-O', ',-O', 'HBe-B-Chemical', '.-O']
['RESULTS-O', ':-O', 'Of-O', 'the-O', '77-O', 'patients-O', 'enrolled-O', 'in-O', 'the-O', 'study-O', ',-O', '73-O', '%-O', 'were-O', 'male-O', 'and-O', '27-O', '%-O', 'were-O', 'female-O', '.-O']
['Mean-O', 'ALT-O', 'and-O', 'AST-O', 'levels-O', 'were-O', '124-O', '.-O']
['4-O', '+-O', '73-O', '.-O']
['4-O', 'and-O', '103-O', '.-O']
['1-O', '+-O', '81-O', 'IU-O', '/-O', 'l-O', ',-O', 'respectively-O', '.-O']
['HBeAg-B-Chemical', 'was-O', 'positive-O', 'in-O', '40-O', '%-O', 'and-O', 'anti-O', ',-O', 'HBe-B-Chemical', 'in-O', '60-O', '%-O', 'of-O', 'the-O', 'patients-O', '.-O']
['Anti-O', ',-O', 'HCV-B-Chemical', 'was-O', 'negative-O', 'in-O', 'all-O', 'of-O', 'them-O', '.-O']
['YMDD-O', 'motif-O', 'mutants-O', 'were-O', 'not-O', 'detected-O', 'in-O', 'any-O', 'of-O', 'the-O', 'patients-O', 'despite-O', 'the-O', 'liver-O', 'enzyme-O', 'levels-O', 'and-O', 'the-O', 'presence-O', 'of-O', 'HBeAg-B-Chemical', 'or-O', 'anti-O', ',-O', 'HBe-O', '.-O']
['CONCLUSION-O', ':-O', 'Although-O', 'the-O', 'natural-O', 'occurrence-O', 'of-O', 'YMDD-O', 'motif-O', 'mutants-O', 'in-O', 'lamivudine-B-Chemical', ',-O', 'untreated-O', 'patients-O', 'with-O', 'chronic-O', 'hepatitis-B-Disease', 'B-I-Disease', 'has-O', 'been-O', 'reported-O', ',-O', 'these-O', 'mutants-O', 'were-O', 'not-O', 'detected-O', 'in-O', 'Iranian-O', 'lamivudine-B-Chemical', ',-O', 'untreated-O', 'chronic-O', 'hepatitis-B-Disease', 'B-I-Disease']
['Branch-O', 'retinal-B-Disease', 'vein-I-Disease', 'occlusion-I-Disease', 'and-O', 'fluoxetine-B-Chemical', '.-O']
['A-O', 'case-O', 'of-O', 'branch-O', 'retinal-B-Disease', 'vein-I-Disease', 'occlusion-I-Disease', 'associated-O', 'with-O', 'fluoxetine-B-Chemical', ',-O', 'induced-O', 'secondary-O', 'hypertension-B-Disease', 'is-O', 'described-O', '.-O']
['Although-O', 'an-O', 'infrequent-O', 'complication-O', 'of-O', 'selective-O', 'serotonin-B-Chemical', 'reuptake-I-Chemical', 'inhibitor-I-Chemical', 'therapy-O', ',-O', 'it-O', 'is-O', 'important-O', 'that-O', 'ophthalmologists-O', 'are-O', 'aware-O', 'that-O', 'these-O', 'agents-O', 'can-O', 'cause-O', 'hypertension-B-Disease']
['The-O', 'differential-O', 'effects-O', 'of-O', 'bupivacaine-B-Chemical', 'and-O', 'lidocaine-B-Chemical', 'on-O', 'prostaglandin-B-Chemical', 'E2-I-Chemical', 'release-O', ',-O', 'cyclooxygenase-O', 'gene-O', 'expression-O', 'and-O', 'pain-B-Disease', 'in-O', 'a-O', 'clinical-O', 'pain-B-Disease', 'model-O', '.-O']
['BACKGROUND-O', ':-O', 'In-O', 'addition-O', 'to-O', 'blocking-O', 'nociceptive-O', 'input-O', 'from-O', 'surgical-O', 'sites-O', ',-O', 'long-O', ',-O', 'acting-O', 'local-O', 'anesthetics-O', 'might-O', 'directly-O', 'modulate-O', 'inflammation-B-Disease', '.-O']
['In-O', 'the-O', 'present-O', 'study-O', ',-O', 'we-O', 'describe-O', 'the-O', 'proinflammatory-O', 'effects-O', 'of-O', 'bupivacaine-B-Chemical', 'on-O', 'local-O', 'prostaglandin-B-Chemical', 'E2-I-Chemical', '(-O', 'PGE2-I-Chemical', ')', 'production-O', 'and-O', 'cyclooxygenase-O', '(-O', 'COX-O', ')', 'gene-O', 'expression-O', 'that-O', 'increases-O', 'postoperative-B-Disease', 'pain-B-Disease', 'in-O', 'human-O', 'subjects-O', '.-O']
['METHODS-O', ':-O', 'Subjects-O', '(-O', 'n-O', '=', '114-O', ')-O', 'undergoing-O', 'extraction-O', 'of-O', 'impacted-O', 'third-O', 'molars-O', 'received-O', 'either-O', '2-O', '%-O', 'lidocaine-B-Chemical', 'or-O', '0-O', '.-O']
['5-O', '%-O', 'bupivacaine-B-Chemical', 'before-O', 'surgery-O', 'and-O', 'either-O', 'rofecoxib-B-Chemical', '50-O', 'mg-O', 'or-O', 'placebo-O', 'orally-O', '90-O', 'min-O', 'before-O', 'surgery-O', 'and-O', 'for-O', 'the-O', 'following-O', '48-O', 'h-O', '.-O']
['Oral-O', 'mucosal-O', 'biopsies-O', 'were-O', 'taken-O', 'before-O', 'surgery-O', 'and-O', '48-O', 'h-O', 'after-O', 'surgery-O', '.-O']
['After-O', 'extraction-O', ',-O', 'a-O', 'microdialysis-O', 'probe-O', 'was-O', 'placed-O', 'at-O', 'the-O', 'surgical-O', 'site-O', 'for-O', 'PGE2-B-Chemical', 'and-O', 'thromboxane-B-Chemical', 'B2-O', '(-O', 'TXB2-B-Chemical', ')-O', 'measurements-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'bupivacaine-B-Chemical', '/-O', 'rofecoxib-B-Chemical', 'group-O', 'reported-O', 'significantly-O', 'less-O', 'pain-B-Disease', ',-O', 'as-O', 'assessed-O', 'by-O', 'a-O', 'visual-O', 'analog-O', 'scale-O', ',-O', 'compared-O', 'with-O', 'the-O', 'other-O', 'three-O', 'treatment-O', 'groups-O', 'over-O', 'the-O', 'first-O', '4-O', 'h-O', '.-O']
['However-O', ',-O', 'the-O', 'bupivacaine-B-Chemical', '/-O', 'placebo-O', 'group-O', 'reported-O', 'significantly-O', 'more-O', 'pain-B-Disease', 'at-O', '24-O', 'h-O', 'and-O', 'PGE2-B-Chemical', 'levels-O', 'during-O', 'the-O', 'first-O', '4-O', 'h-O', 'were-O', 'significantly-O', 'higher-O', 'than-O', 'the-O', 'other-O', 'three-O', 'treatment-O', 'groups-O', '.-O']
['Moreover-O', ',-O', 'bupivacaine-B-Chemical', 'significantly-O', 'increased-O', 'COX-B-Chemical', ',-O', '2-O', 'gene-O', 'expression-O', 'at-O', '48-O', 'h-O', 'as-O', 'compared-O', 'with-O', 'the-O', 'lidocaine-B-Chemical', '/-O', 'placebo-O', 'group-O', '.-O']
['Thromboxane-B-Chemical', 'levels-O', 'were-O', 'not-O', 'significantly-O', 'affected-O', 'by-O', 'any-O', 'of-O', 'the-O', 'treatments-O', ',-O', 'indicating-O', 'that-O', 'the-O', 'effects-O', 'seen-O', 'were-O', 'attributable-O', 'to-O', 'inhibition-O', 'of-O', 'COX-O', ',-O', '2-O', ',-O', 'but-O', 'not-O', 'COX-O', ',-O', '1-O', '.-O']
['CONCLUSIONS-O', ':-O', 'These-O', 'results-O', 'suggest-O', 'that-O', 'bupivacaine-B-Chemical', 'stimulates-O', 'COX-O', ',-O', '2-O', 'gene-O', 'expression-O', 'after-O', 'tissue-O', 'injury-O', ',-O', 'which-O', 'is-O', 'associated-O', 'with-O', 'higher-O', 'PGE2-B-Chemical', 'production-O', 'and-O', 'pain-B-Disease']
['p75NTR-O', 'expression-O', 'in-O', 'rat-O', 'urinary-O', 'bladder-O', 'sensory-O', 'neurons-O', 'and-O', 'spinal-O', 'cord-O', 'with-O', 'cyclophosphamide-B-Chemical', ',-O', 'induced-O', 'cystitis-B-Disease', '.-O']
['A-O', 'role-O', 'for-O', 'nerve-O', 'growth-O', 'factor-O', '(-O', 'NGF-O', ')-O', 'in-O', 'contributing-O', 'to-O', 'increased-O', 'voiding-O', 'frequency-O', 'and-O', 'altered-O', 'sensation-O', 'from-O', 'the-O', 'urinary-O', 'bladder-O', 'has-O', 'been-O', 'suggested-O', '.-O']
['Previous-O', 'studies-O', 'have-O', 'examined-O', 'the-O', 'expression-O', 'and-O', 'regulation-O', 'of-O', 'tyrosine-B-Chemical', 'kinase-O', 'receptors-O', '(-O', 'Trks-O', ')-O', 'in-O', 'micturition-O', 'reflexes-O', 'with-O', 'urinary-O', 'bladder-O', 'inflammation-B-Disease', '.-O']
['The-O', 'present-O', 'studies-O', 'examine-O', 'the-O', 'expression-O', 'and-O', 'regulation-O', 'of-O', 'another-O', 'receptor-O', 'known-O', 'to-O', 'bind-O', 'NGF-O', ',-O', 'p75-O', '(-O', 'NTR-O', ')-O', ',', 'after-O', 'various-O', 'durations-O', 'of-O', 'bladder-O', 'inflammation-O', 'induced-O', 'by-O', 'cyclophosphamide-B-Chemical', '(-O', 'CYP-O', ')-O', '.', 'CYP-O', ',-O', 'induced-O', 'cystitis-B-Disease', 'increased-O', '(-O', 'P-O', '<-O', 'or-O', '=-O', '0-O', ').-O']
['001-O', ')-O', 'p75-O', '(-O', 'NTR-O', ')-O', 'expression-O', 'in-O', 'the-O', 'superficial-O', 'lateral-O', 'and-O', 'medial-O', 'dorsal-O', 'horn-O', 'in-O', 'L1-O', ',-O', 'L2-O', 'and-O', 'L6-O', ',-O', 'S1-O', 'spinal-O', 'segments-O', '.-O']
['The-O', 'number-O', 'of-O', 'p75-O', '(-O', 'NTR-O', ')-O', 'immunoreactive-O', '(-O', 'IR-O', ')-O', 'cells-O', 'in-O', 'the-O', 'lumbosacral-O', 'dorsal-O', 'root-O', 'ganglia-O', '(-O', 'DRG-O', ')-O', 'also-O', 'increased-O', '(-O', 'P-O', '<-O', 'or-O', '=-O', '0-O', '.-O']
['05-O', ')-O', 'with-O', 'CYP-O', ',-O', 'induced-O', 'cystitis-B-Disease', '(-O', 'acute-B-Disease', ',-O', 'intermediate-B-Disease', ',-O', 'and-O', 'chronic-B-Disease', ')-O', '.-O', 'Quantitative-O', ',-O', 'real-O', ',-O', 'time-O', 'polymerase-O', 'chain-O', 'reaction-O', 'also-O', 'demonstrated-O', 'significant-O', 'increases-O', '(-O', 'P-O', '<-O', 'or-O', '=-O', '0-O', '.-O']
['01-O', ')-O', 'in-O', 'p75-O', '(-O', 'NTR-O', ')-O', 'mRNA-O', 'in-O', 'DRG-O', 'with-O', 'intermediate-O', 'and-O', 'chronic-O', 'CYP-B-Chemical', ',-O', 'induced-O', 'cystitis-B-Disease', '.-O']
['Retrograde-O', 'dye-O', ',-O', 'tracing-O', 'techniques-O', 'with-O', 'Fastblue-B-Chemical', 'were-O', 'used-O', 'to-O', 'identify-O', 'presumptive-O', 'bladder-O', 'afferent-O', 'cells-O', 'in-O', 'the-O', 'lumbosacral-O', 'DRG-O', '.-O']
['In-O', 'bladder-O', 'afferent-O', 'cells-O', 'in-O', 'DRG-O', ',-O', 'p75-O', '(-O', 'NTR-O', ')-O', 'IR-O', 'was-O', 'also-O', 'increased-O', '(-O', 'P-O', '<-O', 'or-O', '=-O', '0-O', '.-O']
['01-O', ')-O', 'with-O', 'cystitis-B-Disease', '.-O']
['In-O', 'addition-O', 'to-O', 'increases-O', 'in-O', 'p75-O', '(-O', 'NTR-O', ')-O', 'IR-O', 'in-O', 'DRG-O', 'cell-O', 'bodies-O', ',-O', 'increases-O', '(-O', 'P-O', '<-O', 'or-O', '=-O', '0-O', '.-O']
['001-O', ')-O', 'in-O', 'pericellular-O', '(-O', 'encircling-O', 'DRG-O', 'cells-O', ')-O', 'p75-O', '(-O', 'NTR-O', ')-O', 'IR-O', 'in-O', 'DRG-O', 'also-O', 'increased-O', '.-O']
['Confocal-O', 'analyses-O', 'demonstrated-O', 'that-O', 'pericellular-O', 'p75-O', '(NTR)-O', 'IR-O', 'was-O', 'not-O', 'colocalized-O', 'with-O', 'the-O', 'glial-O', 'marker-O', ',-O', 'glial-O', 'fibrillary-O', 'acidic-O', 'protein-O', '(GFAP)-O', '.-O', 'These-O', 'studies-O', 'demonstrate-O', 'that-O', 'p75-O', '(NTR)-O', 'expression-O', 'in-O', 'micturition-O', 'reflexes-O', 'is-O', 'present-O', 'constitutively-O', 'and-O', 'modified-O', 'by-O', 'bladder-O', 'inflammation-B-Disease']
['Azathioprine-B-Chemical', ',-O', 'induced-O', 'suicidal-O', 'erythrocyte-O', 'death-B-Disease', '.-O']
['BACKGROUND-O', ':-O', 'Azathioprine-B-Chemical', 'is-O', 'widely-O', 'used-O', 'as-O', 'an-O', 'immunosuppressive-O', 'drug-O', '.-O']
['The-O', 'side-O', 'effects-O', 'of-O', 'azathioprine-B-Chemical', 'include-O', 'anemia-B-Disease', ',-O', 'which-O', 'has-O', 'been-O', 'attributed-O', 'to-O', 'bone-B-Disease', 'marrow-I-Disease', 'suppression-I-Disease', '.-O']
['Alternatively-O', ',-O', 'anemia-I-Disease', 'could-O', 'result-O', 'from-O', 'accelerated-O', 'suicidal-O', 'erythrocyte-O', 'death-O', 'or-O', 'eryptosis-O', ',-O', 'which-O', 'is-O', 'characterized-O', 'by-O', 'exposure-O', 'of-O', 'phosphatidylserine-B-Chemical', '(-O', 'PS-O', ')-O', 'at-O', 'the-O', 'erythrocyte-O', 'surface-O', 'and-O', 'by-O', 'cell-O', 'shrinkage-O', '.-O']
['METHODS-O', ':-O', 'The-O', 'present-O', 'experiments-O', 'explored-O', 'whether-O', 'azathioprine-B-Chemical', 'influences-O', 'eryptosis-B-Disease', '.-O']
['According-O', 'to-O', 'annexin-O', 'V-O', 'binding-O', ',-O', 'erythrocytes-O', 'from-O', 'patients-O', 'indeed-O', 'showed-O', 'a-O', 'significant-O', 'increase-O', 'of-O', 'PS-O', 'exposure-O', 'within-O', '1-O', 'week-O', 'of-O', 'treatment-O', 'with-O', 'azathioprine-B-Chemical', '.-O']
['In-O', 'a-O', 'second-O', 'series-O', ',-O', 'cytosolic-O', 'Ca-B-Chemical', '2-O', '+-O', 'activity-O', '(-O', 'Fluo3-O', 'fluorescence-O', ')-O', ',', 'cell-O', 'volume-O', '(-O', 'forward-O', 'scatter-O', ')-O', ',', 'and-O', 'PS-O', ',', 'exposure-O', '(-O', 'annexin-O', 'V-O', 'binding-O', ')-O', 'were-O', 'determined-O', 'by-O', 'FACS-O', 'analysis-O', 'in-O', 'erythrocytes-O', 'from-O', 'healthy-O', 'volunteers-O', '.-O']
['RESULTS-O', ':-O', 'Exposure-O', 'to-O', 'azathioprine-B-Chemical', '(>-O', 'or-O', '=-O', '2-O', 'microg-O', '/-O', 'mL-O', ')-O', 'for-O', '48-O', 'hours-O', 'increased-O', 'cytosolic-O', 'Ca-B-Chemical', '2-O', '+-O', 'activity-O', 'and-O', 'annexin-O', 'V-O', 'binding-O', 'and-O', 'decreased-O', 'forward-O', 'scatter-O', '.-O']
['The-O', 'effect-O', 'of-O', 'azathioprine-B-Chemical', 'on-O', 'both-O', 'annexin-O', 'V-O', 'binding-O', 'and-O', 'forward-O', 'scatter-O', 'was-O', 'significantly-O', 'blunted-O', 'in-O', 'the-O', 'nominal-O', 'absence-O', 'of-O', 'extracellular-O', 'Ca-B-Chemical', '2-O', '+.-O', 'CONCLUSIONS-O', ':-O', 'Azathioprine-B-Chemical', 'triggers-O', 'suicidal-O', 'erythrocyte-O', 'death-O', ',-O', 'an-O', 'effect-O', 'presumably-O', 'contributing-O', 'to-O', 'azathioprine-B-Chemical', ',-O', 'induced-O', 'anemia-B-Disease']
['Clinical-O', 'comparison-O', 'of-O', 'cardiorespiratory-B-Disease', 'effects-O', 'during-O', 'unilateral-O', 'and-O', 'conventional-O', 'spinal-O', 'anaesthesia-O', '.-O']
['BACKGROUND-O', ':-O', 'Spinal-O', 'anaesthesia-O', 'is-O', 'widely-O', 'employed-O', 'in-O', 'clinical-O', 'practice-O', 'but-O', 'has-O', 'the-O', 'main-O', 'drawback-O', 'of-O', 'post-O', ',-O', 'spinal-O', 'block-B-Disease', 'hypotension-B-Disease', '.-O']
['Efforts-O', 'must-O', 'therefore-O', 'continue-O', 'to-O', 'be-O', 'made-O', 'to-O', 'obviate-O', 'this-O', 'setback-O', 'OBJECTIVE-O', ':-O', 'To-O', 'evaluate-O', 'the-O', 'cardiovascular-O', 'and-O', 'respiratory-O', 'changes-O', 'during-O', 'unilateral-O', 'and-O', 'conventional-O', 'spinal-O', 'anaesthesia-O', '.-O']
['METHODS-O', ':-O', 'With-O', 'ethical-O', 'approval-O', ',-O', 'we-O', 'studied-O', '74-O', 'American-O', 'Society-O', 'of-O', 'Anesthesiologists-O', '(-O', 'ASA-O', '),O', 'physical-O', 'status-O', 'class-O', '1-O', 'and-O', '2-O', 'patients-O', 'scheduled-O', 'for-O', 'elective-O', 'unilateral-O', 'lower-O', 'limb-O', 'surgery-O', '.-O']
['Patients-O', 'were-O', 'randomly-O', 'allocated-O', 'into-O', 'one-O', 'of-O', 'two-O', 'groups-O', ':-O', 'lateral-O', 'and-O', 'conventional-O', 'spinal-O', 'anaesthesia-O', 'groups-O', '.-O']
['In-O', 'the-O', 'lateral-O', 'position-O', 'with-O', 'operative-O', 'side-O', 'down-O', ',-O', 'patients-O', 'recived-O', '10-O', 'mg-O', '(-O', '2mls-O', ')-O', 'of-O', '0-O', '.-O']
['5-O', '%-O', 'hyperbaric-O', 'bupivacaine-B-Chemical', 'through-O', 'a-O', '25-O', ',-O', 'gauge-O', 'spinal-O', 'needle-O', '.-O']
['Patients-O', 'in-O', 'the-O', 'unilateral-O', 'group-O', 'were-O', 'maintained-O', 'in-O', 'the-O', 'lateral-O', 'position-O', 'for-O', '15-O', 'minutes-O', 'following-O', 'spinal-O', 'injection-O', 'while-O', 'those-O', 'in-O', 'the-O', 'conventional-O', 'group-O', 'were-O', 'turned-O', 'supine-O', 'immediately-O', 'after-O', 'injection-O', '.-O']
['Blood-O', 'pressure-O', ',-O', 'heart-O', 'rate-O', ',-O', 'respiratory-O', 'rate-O', 'and-O', 'oxygen-B-Chemical', 'saturation-O', 'were-O', 'monitored-O', 'over-O', '1-O', 'hour-O', '.-O']
['RESULTS-O', ':-O', 'Three-O', 'patients-O', '(-O', '8-O', '.-O']
['1-O', ')-O', 'in-O', 'the-O', 'unilateral-O', 'group-O', 'and-O', '5-O', '(-O', '13-O', '.-O']
['5-O', ')-O', 'in-O', 'the-O', 'conventional-O', 'group-O', 'developed-O', 'hypotension-B-Disease', ',-O', 'P-O', '=-O', '0-O', '.-O']
['71-O', '.-O']
['Four-O', '(-O', '10-O', '.-O']
['8-O', ')-O', 'patients-O', 'in-O', 'the-O', 'conventional-O', 'group-O', 'and-O', '1-O', '(-O', '2-O', '.-O']
['7-O', ')-O', 'in-O', 'the-O', 'unilateral-O', 'group-O', ',-O', 'P-O', '=O', '0-O', '.-O']
['17-O', 'required-O', 'epinephrine-B-Chemical', 'infusion-O', 'to-O', 'treat-O', 'hypotension-B-Disease', '.-O']
['Patients-O', 'in-O', 'the-O', 'conventional-O', 'group-O', 'had-O', 'statistically-O', 'significant-O', 'greater-O', 'fall-O', 'in-O', 'the-O', 'systolic-O', 'blood-O', 'pressures-O', 'at-O', '15-O', ',-O', '30-O', 'and-O', '45-O', 'minutes-O', 'when-O', 'compared-O', 'to-O', 'the-O', 'baseline-O', '(-O', 'P-O', '=-O', '0-O', '.-O']
['003-O', ',-O', '0-O', '.-O']
['001-O', 'and-O', '0-O', '.-O']
['004-O', ').-O', 'The-O', 'mean-O', 'respiratory-O', 'rate-O', 'and-O', 'oxygen-B-Chemical', 'saturations-O', 'in-O', 'the-O', 'two-O', 'groups-O', 'were-O', 'similar-O', '.-O']
['CONCLUSION-O', ':-O', 'Compared-O', 'to-O', 'conventional-O', 'spinal-O', 'anaesthesia-O', ',-O', 'unilateral-O', 'spinal-O', 'anaesthesia-O', 'was-O', 'associated-O', 'with-O', 'fewer-O', 'cardiovascular-O', 'perturbations-O', '.-O']
['Also-O', ',-O', 'the-O', 'type-O', 'of-O', 'spinal-B-Disease', 'block-I-Disease', 'instituted-O', 'affected-O', 'neither-O', 'the-O', 'respiratory-O', 'rate-O', 'nor-O', 'the-O', 'arterial-O', 'oxygen-B-Chemical']
['Spectrum-O', 'of-O', 'adverse-O', 'events-O', 'after-O', 'generic-O', 'HAART-O', 'in-O', 'southern-O', 'Indian-O', 'HIV-infected-B-Disease', 'patients-O', '.-O']
['To-O', 'determine-O', 'the-O', 'incidence-O', 'of-O', 'clinically-O', 'significant-O', 'adverse-O', 'events-O', 'after-O', 'long-O', ',-O', 'term-O', ',-O', 'fixed-O', ',-O', 'dose-O', ',-O', 'generic-O', 'highly-O', 'active-O', 'antiretroviral-O', 'therapy-O', '(-O', 'HAART-O', ')-O', 'use-O', 'among-O', 'HIV-infected-B-Disease', 'individuals-O', 'in-O', 'South-O', 'India-O', ',-O', 'we-O', 'examined-O', 'the-O', 'experiences-O', 'of-O', '3154-O', 'HIV-infected-B-Disease', 'individuals-O', 'who-O', 'received-O', 'a-O', 'minimum-O', 'of-O', '3-O', 'months-O', 'of-O', 'generic-O', 'HAART-O', 'between-O', 'February-O', '1996-O', 'and-O', 'December-O', '2006-O', 'at-O', 'a-O', 'tertiary-O', 'HIV-B-Disease', 'care-O', 'referral-O', 'center-O', 'in-O', 'South-O', 'India-O', '.-O']
['The-O', 'most-O', 'common-O', 'regimens-O', 'were-O', '3TC-B-Chemical', '+-O', 'd4T-B-Chemical', '+-O', 'nevirapine-B-Chemical', '(-O', 'NVP-B-Chemical', ')-O', '(-O', '54-O', '.-O']
['8-O', ')-O', 'zidovudine-B-Chemical', '(-O', 'AZT-B-Chemical', ')+-O', '3TC-B-Chemical', '+-O', 'NVP-B-Chemical', '(-O', '14-O', '.-O']
['5-O', ')-O', '3TC-B-Chemical', '+-O', 'd4T-B-Chemical', '+-O', 'efavirenz-B-Chemical', '(-O', 'EFV-B-Chemical', ')-O', '(-O', '20-O', '.-O']
['1-O', ')-O', 'and-O', 'AZT-B-Chemical', '+-O', '3TC-B-Chemical', '+-O', 'EFV-B-Chemical', '(-O', '5-O', '.-O']
['4-O', ').-O', 'The-O', 'most-O', 'common-O', 'adverse-O', 'events-O', 'and-O', 'median-O', 'CD4-O', 'at-O', 'time-O', 'of-O', 'event-O', 'were-O', 'rash-B-Disease', '(-O', '15-O', '.-O']
['2-O', ';-O', 'CD4-O', ',-O', '285-O', 'cells-O', '/', 'microL-O', ')-O', 'and-O', 'peripheral-B-Disease', 'neuropathy-I-Disease', '(-O', '9-O', '.-O']
['0-O', '%-O', 'and-O', '348-O', 'cells-O', '/-O', 'microL-O', ').-O', 'Clinically-O', 'significant-O', 'anemia-B-Disease', '(-O', 'hemoglobin-O', '<-O', '7-O', 'g-O', '/-O', 'dL-O', ')-O', 'was-O', 'observed-O', 'in-O', '5-O', '.-O']
['4-O', '%-O', 'of-O', 'patients-O', '(-O', 'CD4-B-Chemical', ',-O', '165-O', 'cells-O', '/-O', 'microL-O', ')-O', 'and-O', 'hepatitis-B-Disease', '(-O', 'clinical-O', 'jaundice-B-Disease', 'with-O', 'alanine-B-Chemical', 'aminotransferase-O', '>-O', '5-O', 'times-O', 'upper-O', 'limits-O', 'of-O', 'normal-O', ')-O', 'in-O', '3-O', '.-O']
['5-O', '%-O', 'of-O', 'patients-O', '(-O', 'CD4-O', ',-O', '260-O', 'cells-O', '/-O', 'microL-O', ').-O', 'Women-O', 'were-O', 'significantly-O', 'more-O', 'likely-O', 'to-O', 'experience-O', 'lactic-O', 'acidosis-B-Disease', ',-O', 'while-O', 'men-O', 'were-O', 'significantly-O', 'more-O', 'likely-O', 'to-O', 'experience-O', 'immune-O', 'reconstitution-O', 'syndrome-B-Disease', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'Among-O', 'the-O', 'patients-O', 'with-O', '1-O', 'year-O', 'of-O', 'follow-O', ',-O', 'up-O', ',-O', 'NVP-B-Chemical', 'therapy-O', 'was-O', 'significantly-O', 'associated-O', 'with-O', 'developing-O', 'rash-B-Disease', 'and-O', 'd4T-B-Chemical', 'therapy-O', 'with-O', 'developing-O', 'peripheral-B-Disease', 'neuropathy-I-Disease', '(-O', 'p-O', '<-O', '0-O', '.-O']
['05-O', ').-O', 'Anemia-B-Disease', 'and-O', 'hepatitis-B-Disease', 'often-O', 'occur-O', 'within-O', '12-O', 'weeks-O', 'of-O', 'initiating-O', 'generic-O', 'HAART-O', '.-O']
['Frequent-O', 'and-O', 'early-O', 'monitoring-O', 'for-O', 'these-O', 'toxicities-B-Disease']
['Thalidomide-B-Chemical', 'and-O', 'sensory-O', 'neurotoxicity-B-Disease', ':-O', 'a-O', 'neurophysiological-O', 'study-O', '.-O']
['BACKGROUND-O', ':-O', 'Recent-O', 'studies-O', 'confirmed-O', 'a-O', 'high-O', 'incidence-O', 'of-O', 'sensory-O', 'axonal-B-Disease', 'neuropathy-I-Disease', 'in-O', 'patients-O', 'treated-O', 'with-O', 'different-O', 'doses-O', 'of-O', 'thalidomide-B-Chemical', '.-O']
['The-O', 'study-O', 'x-O', 's-O', 'aims-O', 'were-O', 'to-O', 'measure-O', 'variations-O', 'in-O', 'sural-O', 'nerve-O', 'sensory-O', 'action-O', 'potential-O', '(-O', 'SAP-O', ')-O', 'amplitude-O', 'in-O', 'patients-O', 'with-O', 'refractory-O', 'cutaneous-O', 'lupus-O', 'erythematosus-O', '(-O', 'CLE-O', ')-O', 'treated-O', 'with-O', 'thalidomide-B-Chemical', 'and-O', 'use-O', 'these-O', 'findings-O', 'to-O', 'identify-O', 'the-O', 'neurotoxic-O', 'potential-O', 'of-O', 'thalidomide-B-Chemical', 'and-O', 'the-O', 'recovery-O', 'capacity-O', 'of-O', 'sensory-O', 'fibres-O', 'after-O', 'discontinuation-O', 'of-O', 'treatment-O', '.-O']
['PATIENTS-O', 'AND-O', 'METHODS-O', ':-O', 'Clinical-O', 'and-O', 'electrophysiological-O', 'data-O', 'in-O', '12-O', 'female-O', 'patients-O', 'with-O', 'CLE-B-Disease', 'during-O', 'treatment-O', 'with-O', 'thalidomide-B-Chemical', 'and-O', 'up-O', 'to-O', '47-O', 'months-O', 'after-O', 'discontinuation-O', 'of-O', 'treatment-O', 'were-O', 'analysed-O', '.-O']
['Sural-O', 'nerve-O', 'SAP-O', 'amplitude-O', 'reduction-O', '>-O', 'or-O', '=-O', '40-O', '%-O', 'was-O', 'the-O', 'criteria-O', 'for-O', 'discontinuing-O', 'therapy-O', '.-O']
['RESULTS-O', ':-O', 'During-O', 'treatment-O', ',-O', '11-O', 'patients-O', 'showed-O', 'a-O', 'reduction-O', 'in-O', 'sural-O', 'nerve-O', 'SAP-O', 'amplitude-O', 'compared-O', 'to-O', 'baseline-O', 'values-O', '(-O', '9-O', 'with-O', 'a-O', 'reduction-O', '>-O', 'or-O', '=-O', '50-O', '%-O', 'and-O', '2-O', '<-O', '50-O', ')-O', '.-O', 'One-O', 'patient-O', 'showed-O', 'no-O', 'changes-O', 'in-O', 'SAP-O', 'amplitude-O', '.-O']
['Five-O', 'patients-O', 'complained-O', 'of-O', 'paresthesias-B-Disease', 'and-O', 'leg-O', 'cramps-B-Disease', '.-O']
['After-O', 'thalidomide-B-Chemical', 'treatment-O', ',-O', 'sural-O', 'SAP-O', 'amplitude-O', 'recovered-O', 'in-O', '3-O', 'patients-O', '.-O']
['At-O', 'detection-O', 'of-O', 'reduction-O', 'in-O', 'sural-O', 'nerve-O', 'SAP-O', 'amplitude-O', ',-O', 'the-O', 'median-O', 'thalidomide-B-Chemical', 'cumulative-O', 'dose-O', 'was-O', '21-O', '.-O']
['4-O', 'g-O', '.-O']
['The-O', 'threshold-O', 'neurotoxic-B-Disease', 'dosage-O', 'is-O', 'lower-O', 'than-O', 'previously-O', 'reported-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Sural-O', 'nerve-O', 'SAP-O', 'amplitude-O', 'reduction-O', 'is-O', 'a-O', 'reliable-O', 'and-O', 'sensitive-O', 'marker-O', 'of-O', 'degeneration-B-Disease', 'and-O', 'recovery-O', 'of-O', 'sensory-O', 'fibres-O', '.-O']
['This-O', 'electrophysiological-O', 'parameter-O', 'provides-O', 'information-O', 'about-O', 'subclinical-O', 'neurotoxic-B-Disease', 'potential-O', 'of-O', 'thalidomide-B-Chemical']
['Amiodarone-B-Chemical', ',-O', 'related-O', 'pulmonary-O', 'mass-I-Disease', 'and-O', 'unique-O', 'membranous-O', 'glomerulonephritis-B-Disease', 'in-O', 'a-O', 'patient-O', 'with-O', 'valvular-B-Disease', 'heart-I-Disease', 'disease-I-Disease', ':-O', 'Diagnostic-O', 'pitfall-O', 'and-O', 'new-O', 'findings-O', '.-O']
['Amiodarone-B-Chemical', 'is-O', 'an-O', 'anti-O', ',-O', 'arrhythmic-O', 'drug-O', 'for-O', 'life-O', ',-O', 'threatening-O', 'tachycardia-B-Disease', ',-O', 'but-O', 'various-O', 'adverse-O', 'effects-O', 'have-O', 'been-O', 'reported-O', '.-O']
['Reported-O', 'herein-O', 'is-O', 'an-O', 'autopsy-O', 'case-O', 'of-O', 'valvular-B-Disease', 'heart-I-Disease', 'disease-I-Disease', ',-O', 'in-O', 'a-O', 'patient-O', 'who-O', 'developed-O', 'a-O', 'lung-O', 'mass-I-Disease', '(-O', '1-O', '.-O']
['5-O', 'cm-O', 'in-O', 'diameter-O', ')-O', 'and-O', 'proteinuria-B-Disease', '(-O', '2-O', '.-O']
['76-O', 'g-O', '/-O', 'day-O', ')-O', 'after-O', 'treatment-O', 'with-O', 'amiodarone-B-Chemical', 'for-O', 'a-O', 'long-O', 'time-O', '.-O']
['The-O', 'lung-O', 'mass-O', 'was-O', 'highly-O', 'suspected-O', 'to-O', 'be-O', 'lung-B-Disease', 'cancer-I-Disease', 'on-O', 'CT-O', 'and-O', 'positron-O', 'emission-O', 'tomography-O', ',-O', 'but-O', 'histologically-O', 'the-O', 'lesion-O', 'was-O', 'composed-O', 'of-O', 'lymphoplasmacytic-O', 'infiltrates-O', 'in-O', 'alveolar-O', 'walls-O', 'and-O', 'intra-O', ',-O', 'alveolar-O', 'accumulation-O', 'of-O', 'foamy-O', 'macrophages-O', 'containing-O', 'characteristic-O', 'myelinoid-O', 'bodies-O', ',-O', 'indicating-O', 'that-O', 'it-O', 'was-O', 'an-O', 'amiodarone-B-Chemical', ',-O', 'related-O', 'lesion-O', '.-O']
['In-O', 'addition-O', ',-O', 'the-O', 'lung-O', 'tissue-O', 'had-O', 'unevenly-O', 'distributed-O', 'hemosiderin-B-Chemical', 'deposition-O', ',-O', 'and-O', 'abnormally-O', 'tortuous-O', 'capillaries-O', 'were-O', 'seen-O', 'in-O', 'the-O', 'mass-O', 'and-O', 'in-O', 'heavily-O', 'hemosiderotic-O', 'lung-O', 'portions-O', 'outside-O', 'the-O', 'mass-O', '.-O']
['In-O', 'the-O', 'kidneys-O', ',-O', 'glomeruli-O', 'had-O', 'membrane-O', 'spikes-O', ',-O', 'prominent-O', 'swelling-O', 'of-O', 'podocytes-O', 'and-O', 'subepithelial-O', 'deposits-O', ',-O', 'which-O', 'were-O', 'sometimes-O', 'large-O', 'and-O', 'hump-O', ',-O', 'like-O', '.-O']
['Autoimmune-B-Disease', 'diseases-I-Disease', ',-O', 'viral-O', 'hepatitis-B-Disease', ',-O', 'malignant-O', 'neoplasms-B-Disease', 'or-O', 'other-O', 'diseases-O', 'with-O', 'a-O', 'known-O', 'relationship-O', 'to-O', 'membranous-O', 'glomerulonephritis-B-Disease', 'were-O', 'not-O', 'found-O', '.-O']
['The-O', 'present-O', 'case-O', 'highlights-O', 'the-O', 'possibility-O', 'that-O', 'differential-O', 'diagnosis-O', 'between-O', 'an-O', 'amiodarone-B-Chemical', ',-O', 'related-O', 'pulmonary-O', 'lesion-O', 'and-O', 'a-O', 'neoplasm-O', 'can-O', 'be-O', 'very-O', 'difficult-O', 'radiologically-O', ',-O', 'and-O', 'suggests-O', 'that-O', 'membranous-O', 'glomerulonephritis-B-Disease', 'might-O', 'be-O', 'another-O', 'possible-O', 'complication-O', 'of-O', 'amiodarone-B-Chemical']
['Risk-O', 'of-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease', 'associated-O', 'with-O', 'initial-O', 'sulphonylurea-B-Chemical', 'treatment-O', 'of-O', 'patients-O', 'with-O', 'type-B-Disease', '2-O', 'diabetes-I-Disease', ':-O', 'a-O', 'matched-O', 'case-O', ',-O', 'control-O', 'study-O', '.-O']
['AIMS-O', ':-O', 'This-O', 'study-O', 'sought-O', 'to-O', 'assess-O', 'the-O', 'risk-O', 'of-O', 'developing-O', 'coronary-B-Disease', 'artery-I-Disease', 'disease-I-Disease', '(-O', 'CAD-B-Disease', ')-O', 'associated-O', 'with-O', 'initial-O', 'treatment-O', 'of-O', 'type-O', '2-O', 'diabetes-B-Disease', 'with-O', 'different-O', 'sulphonylureas-B-Chemical', '.-O']
['METHODS-O', ':-O', 'In-O', 'type-O', '2-O', 'diabetic-B-Disease', 'patients-O', ',-O', 'cases-O', 'who-O', 'developed-O', 'CAD-B-Disease', 'were-O', 'compared-O', 'retrospectively-O', 'with-O', 'controls-O', 'that-O', 'did-O', 'not-O', '.-O']
['The-O', '20-O', ',-O', 'year-O', 'risk-O', 'of-O', 'CAD-B-Disease', 'at-O', 'diagnosis-O', 'of-O', 'diabetes-B-Disease', ',-O', 'using-O', 'the-O', 'UKPDS-O', 'risk-O', 'engine-O', ',-O', 'was-O', 'used-O', 'to-O', 'match-O', 'cases-O', 'with-O', 'controls-O', '.-O']
['RESULTS-O', ':-O', 'The-O', '76-O', 'cases-O', 'of-O', 'CAD-B-Disease', 'were-O', 'compared-O', 'with-O', '152-O', 'controls-O', '.-O']
['The-O', 'hazard-O', 'of-O', 'developing-O', 'CAD-B-Disease', '(-O', '95-O', '%-O', 'CI-O', ')', 'associated-O', 'with-O', 'initial-O', 'treatment-O', 'increased-O', 'by-O', '2-O', '.-O']
['4-O', ',-O', 'fold-O', '(-O', '1-O', '.-O']
['3-O', ',-O', '4-O', '.-O']
['3-O', ',-O', 'P-O', '=O', '0-O', '.-O']
['004-O', ')-O', 'with-O', 'glibenclamide-B-Chemical', ';-O', '2-O', ',-O', 'fold-O', '(-O', '0-O', '.-O']
['9-O', ',-O', '4-O', '.-O']
['6-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['099-O', ')-O', 'with-O', 'glipizide-B-Chemical', ';-O', '2-O', '.-O']
['9-O', ',-O', 'fold-O', '(-O', '1-O', '.-O']
['6-O', ',-O', '5-O', '.-O']
['1-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['000-O', ')-O', 'with-O', 'either-O', ',-O', 'and-O', 'was-O', 'unchanged-O', 'with-O', 'metformin-B-Chemical', '.-O']
['The-O', 'hazard-O', 'decreased-O', '0-O', '.-O']
['3-O', ',-O', 'fold-O', '(-O', '0-O', '.-O']
['7-O', ',-O', '1-O', '.-O']
['7-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['385-O', ')-O', 'with-O', 'glimepiride-B-Chemical', ',-O', '0-O', '.-O']
['4-O', ',-O', 'fold-O', '(-O', '0-O', '.-O']
['7-O', ',-O', '1-O', '.-O']
['3-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['192-O', ')-O', 'with-O', 'gliclazide-B-Chemical', ',-O', 'and-O', '0-O', '.-O']
['4-O', ',-O', 'fold-O', '(-O', '0-O', '.-O']
['7-O', ',-O', '1-O', '.-O']
['1-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['09-O', ')-O', 'with-O', 'either-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Initiating-O', 'treatment-O', 'of-O', 'type-O', '2-O', 'diabetes-B-Disease', 'with-O', 'glibenclamide-B-Chemical', 'or-O', 'glipizide-B-Chemical', 'is-O', 'associated-O', 'with-O', 'increased-O', 'risk-O', 'of-O', 'CAD-B-Disease', 'in-O', 'comparison-O', 'to-O', 'gliclazide-B-Chemical', 'or-O', 'glimepiride-B-Chemical', '.-O']
['If-O', 'confirmed-O', ',-O', 'this-O', 'may-O', 'be-O', 'important-O', 'because-O', 'most-O', 'Indian-O', 'patients-O', 'receive-O', 'the-O', 'cheaper-O', 'older-O', 'sulphonylureas-B-Chemical']
['Reduced-O', 'progression-O', 'of-O', 'adriamycin-B-Chemical', 'nephropathy-B-Disease', 'in-O', 'spontaneously-O', 'hypertensive-B-Disease', 'rats-O', 'treated-O', 'by-O', 'losartan-B-Chemical', '.-O']
['BACKGROUND-O', ':-O', 'The-O', 'aim-O', 'of-O', 'the-O', 'study-O', 'was-O', 'to-O', 'investigate-O', 'the-O', 'antihypertensive-O', 'effects-O', 'of-O', 'angiotensin-B-Chemical', 'II-I-Chemical', 'type-O', '1-O', 'receptor-O', 'blocker-O', ',-O', 'losartan-B-Chemical', ',-O', 'and-O', 'its-O', 'potential-O', 'in-O', 'slowing-O', 'down-O', 'renal-O', 'disease-O', 'progression-O', 'in-O', 'spontaneously-O', 'hypertensive-B-Disease', 'rats-O', '(-O', 'SHR-O', ')-O', 'with-O', 'adriamycin-B-Chemical', '(-O', 'ADR-B-Chemical', ')-O', 'nephropathy-B-Disease', '.-O']
['METHODS-O', ':-O', 'Six-O', ',-O', 'month-O', ',-O', 'old-O', 'female-O', 'SHR-O', 'were-O', 'randomly-O', 'selected-O', 'in-O', 'six-O', 'groups-O', '.-O']
['Two-O', 'control-O', 'groups-O', '(-O', 'SH-O', '(-O', '6-O', ')-O', ',', 'SH-O', '(-O', '12-O', '))-O', 'received-O', 'vehicle-O', '.-O']
['Groups-O', 'ADR-B-Chemical', '(-O', '6-O', '),,-O', 'ADR-B-Chemical', '+-O', 'LOS-O', '(-O', '6-O', ')-O', 'and-O', 'ADR-B-Chemical', '(-O', '12-O', ')-O', 'and-O', 'ADR-B-Chemical', '+-O', 'LOS-O', '(-O', '12-O', ')-O', 'received-O', 'ADR-B-Chemical', '(-O', '2-O', 'mg-O', '/-O', 'kg-O', '/-O', 'b-O', '.-O']
['w-O', '.-O']
['i-O', '.-O']
['v-O', ')-O', 'twice-O', 'in-O', 'a-O', '3-O', ',-O', 'week-O', 'interval-O', '.-O']
['Group-O', 'ADR-O', '+-O', 'LOS-O', '(-O', '6-O', ')-O', 'received-O', 'losartan-B-Chemical', '(-O', '10-O', 'mg-O', '/-O', 'kg-O', '/-O', 'b-O', '.-O']
['w-O', './-O', 'day-O', 'by-O', 'gavages-O', ')-O', 'for-O', '6-O', 'weeks-O', 'and-O', 'group-O', 'ADR-B-Chemical', '+-O', 'LOS-O', '(-O', '12-O', ')-O', 'for-O', '12-O', 'weeks-O', 'after-O', 'second-O', 'injection-O', 'of-O', 'ADR-B-Chemical', '.-O']
['Animals-O', 'were-O', 'killed-O', 'after-O', '6-O', 'or-O', '12-O', 'weeks-O', ',-O', 'respectively-O', '.-O']
['Haemodynamic-O', 'measurements-O', 'were-O', 'performed-O', 'on-O', 'anaesthetized-O', 'animals-O', ',-O', 'blood-O', 'and-O', 'urine-O', 'samples-O', 'were-O', 'taken-O', 'for-O', 'biochemical-O', 'analysis-O', 'and-O', 'the-O', 'left-O', 'kidney-O', 'was-O', 'processed-O', 'for-O', 'morphological-O', 'studies-O', '.-O']
['RESULTS-O', ':-O', 'Short-O', ',-O', 'term-O', 'losartan-B-Chemical', 'treatment-O', ',-O', 'besides-O', 'antihypertensive-O', 'effect-O', ',-O', 'improved-O', 'glomerular-O', 'filtration-O', 'rate-O', 'and-O', 'ameliorated-O', 'glomerulosclerosis-B-Disease', 'resulting-O', 'in-O', 'decreased-O', 'proteinuria-B-Disease', '.-O']
['Prolonged-O', 'treatment-O', 'with-O', 'losartan-B-Chemical', 'showed-O', 'further-O', 'reduction-O', 'of-O', 'glomerulosclerosis-B-Disease', 'associated-O', 'with-O', 'reduced-O', 'progression-O', 'of-O', 'tubular-O', 'atrophy-O', 'and-O', 'interstitial-O', 'fibrosis-O', ',-O', 'thus-O', 'preventing-O', 'heavy-O', 'proteinuria-B-Disease', 'and-O', 'chronic-B-Disease', 'renal-I-Disease', 'failure-I-Disease', '.-O']
['Losartan-B-Chemical', 'reduced-O', 'uraemia-B-Disease', 'and-O', 'increased-O', 'urea-B-Chemical', 'clearance-O', 'in-O', 'advanced-O', 'ADR-B-Chemical', 'nephropathy-B-Disease', 'in-O', 'SHR-O', '.-O']
['Histological-O', 'examination-O', 'showed-O', 'that-O', 'losartan-B-Chemical', 'could-O', 'prevent-O', 'tubular-O', 'atrophy-I-Disease', ',-O', 'interstitial-O', 'infiltration-I-Disease', 'and-O', 'fibrosis-I-Disease', 'in-O', 'ADR-B-Chemical', 'nephropathy-B-Disease', '.-O']
['CONCLUSION-O', ':-O', 'Losartan-B-Chemical', 'reduces-O', 'the-O', 'rate-O', 'of-O', 'progression-O', 'of-O', 'ADR-B-Chemical', ',-O', 'induced-O', 'focal-B-Disease', 'segmental-I-Disease', 'glomerulosclerosis-I-Disease', 'to-O', 'end-stage-B-Disease', 'renal-I-Disease', 'disease-I-Disease']
['The-O', 'risks-O', 'of-O', 'aprotinin-B-Chemical', 'and-O', 'tranexamic-B-Chemical', 'acid-I-Chemical', 'in-O', 'cardiac-O', 'surgery-O', ':-O', 'a-O', 'one-O', ',-O', 'year-O', 'follow-O', '--O', 'up-O', 'of-O', '1188-O', 'consecutive-O', 'patients-O', '.-O']
['BACKGROUND-O', ':-O', 'Our-O', 'aim-O', 'was-O', 'to-O', 'investigate-O', 'postoperative-O', 'complications-O', 'and-O', 'mortality-O', 'after-O', 'administration-O', 'of-O', 'aprotinin-B-Chemical', 'compared-O', 'to-O', 'tranexamic-B-Chemical', 'acid-I-Chemical', 'in-O', 'an-O', 'unselected-O', ',-O', 'consecutive-O', 'cohort-O', '.-O']
['METHODS-O', ':-O', 'Perioperative-O', 'data-O', 'from-O', 'consecutive-O', 'cardiac-O', 'surgery-O', 'patients-O', 'were-O', 'prospectively-O', 'collected-O', 'between-O', 'September-O', '2005-O', 'and-O', 'June-O', '2006-O', 'in-O', 'a-O', 'university-O', ',-O', 'affiliated-O', 'clinic-O', '(-O', 'n-O', '=-O', '1188-O', ').-O', 'During-O', 'the-O', 'first-O', '5-O', 'mo-O', ',-O', '596-O', 'patients-O', 'received-O', 'aprotinin-B-Chemical', '(-O', 'Group-O', 'A-O', ');-O', 'in-O', 'the-O', 'next-O', '5-O', 'mo-O', ',-O', '592-O', 'patients-O', 'were-O', 'treated-O', 'with-O', 'tranexamic-B-Chemical', 'acid-I-Chemical', '(-O', 'Group-O', 'T-O', ').-O', 'Except-O', 'for-O', 'antifibrinolytic-O', 'therapy-O', ',-O', 'the-O', 'anesthetic-O', 'and-O', 'surgical-O', 'protocols-O', 'remained-O', 'unchanged-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'pre-O', ',-O', 'and-O', 'intraoperative-O', 'variables-O', 'were-O', 'comparable-O', 'between-O', 'the-O', 'treatment-O', 'groups-O', '.-O']
['Postoperatively-O', ',-O', 'a-O', 'significantly-O', 'higher-O', 'incidence-O', 'of-O', 'seizures-B-Disease', 'was-O', 'found-O', 'in-O', 'Group-O', 'T-O', '(-O', '4-O', '.-O']
['6-O', '%-O', 'vs-O', '1-O', '.-O']
['2-O', ',-O', 'P-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'This-O', 'difference-O', 'was-O', 'also-O', 'significant-O', 'in-O', 'the-O', 'primary-O', 'valve-O', 'surgery-O', 'and-O', 'the-O', 'high-O', 'risk-O', 'surgery-O', 'subgroups-O', '(-O', '7-O', '.-O']
['9-O', '%-O', 'vs-O', '1-O', '.-O']
['2-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['003-O', ';-O', '7-O', '.-O']
['3-O', '%-O', 'vs-O', '2-O', '.-O']
['4-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['035-O', ',-O', 'respectively-O', ')-O', '.-O', 'Persistent-O', 'atrial-B-Disease', 'fibrillation-I-Disease', '(-O', '7-O', '.-O']
['9-O', '%-O', 'vs-O', '2-O', '.-O']
['3-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['020-O', ')-O', 'and-O', 'renal-B-Disease', 'failure-I-Disease', '(-O', '9-O', '.-O']
['7-O', '%-O', 'vs-O', '1-O', '.-O']
['7-O', ',-O', 'P-O', '=O', '0-O', '.-O']
['002-O', ')-O', 'were-O', 'also-O', 'more-O', 'common-O', 'in-O', 'Group-O', 'T-O', ',-O', 'in-O', 'the-O', 'primary-O', 'valve-O', 'surgery-O', 'subgroup-O', '.-O']
['On-O', 'the-O', 'contrary-O', ',-O', 'among-O', 'primary-O', 'coronary-O', 'artery-O', 'bypass-O', 'surgery-O', 'patients-O', ',-O', 'there-O', 'were-O', 'more-O', 'acute-B-Disease', 'myocardial-I-Disease', 'infarctions-I-Disease', 'and-O', 'renal-B-Disease', 'dysfunction-I-Disease', 'in-O', 'Group-O', 'A-O', '(-O', '5-O', '.-O']
['8-O', '%-O', 'vs-O', '2-O', '.-O']
['0-O', ',-O', 'P-O', '=', '0-O', '.-O']
['027-O', ';-O', '22-O', '.-O']
['5-O', '%-O', 'vs-O', '15-O', '.-O']
['2-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['036-O', ',-O', 'respectively-O', ').-O', 'The-O', '1-O', ',-O', 'yr-O', 'mortality-O', 'was-O', 'significantly-O', 'higher-O', 'after-O', 'aprotinin-B-Chemical', 'treatment-O', 'in-O', 'the-O', 'high-O', 'risk-O', 'surgery-O', 'group-O', '(-O', '17-O', '.-O']
['7-O', '%-O', 'vs-O', '9-O', '.-O']
['8-O', ',-O', 'P-O', '=O', '0-O', '.-O']
['034-O', ').-O', 'CONCLUSION-O', ':-O', 'Both-O', 'antifibrinolytic-O', 'drugs-O', 'bear-O', 'the-O', 'risk-O', 'of-O', 'adverse-O', 'outcome-O', 'depending-O', 'on-O', 'the-O', 'type-O', 'of-O', 'cardiac-O', 'surgery-O', '.-O']
['Administration-O', 'of-O', 'aprotinin-O', 'should-O', 'be-O', 'avoided-O', 'in-O', 'coronary-B-Disease', 'artery-O', 'bypass-O', 'graft-O', 'and-O', 'high-O', 'risk-O', 'patients-O', ',-O', 'whereas-O', 'administration-O', 'of-O', 'tranexamic-B-Chemical', 'acid-I-Chemical']
['The-O', 'biological-O', 'properties-O', 'of-O', 'the-O', 'optical-O', 'isomers-O', 'of-O', 'propranolol-B-Chemical', 'and-O', 'their-O', 'effects-O', 'on-O', 'cardiac-O', 'arrhythmias-B-Disease', '.-O']
['1-O', '.-O']
['The-O', 'optical-O', 'isomers-O', 'of-O', 'propranolol-B-Chemical', 'have-O', 'been-O', 'compared-O', 'for-O', 'their-O', 'beta-O', ',-O', 'blocking-O', 'and-O', 'antiarrhythmic-O', 'activities-O', '.-O']
['2-O', '.-O']
['In-O', 'blocking-O', 'the-O', 'positive-O', 'inotropic-O', 'and-O', 'chronotropic-O', 'responses-O', 'to-O', 'isoprenaline-B-Chemical', ',-O', 'propranolol-B-Chemical', 'had-O', 'less-O', 'than-O', 'one-O', 'hundredth-O', 'the-O', 'potency-O', 'of-O', '(-)-O', 'propranolol-B-Chemical', '.-O']
['At-O', 'dose-O', 'levels-O', 'of-O', ',-O', 'propranolol-B-Chemical', 'which-O', 'attenuated-O', 'the-O', 'responses-O', 'to-O', 'isoprenaline-B-Chemical', ',-O', 'there-O', 'was-O', 'a-O', 'significant-O', 'prolongation-O', 'of-O', 'the-O', 'PR-O', 'interval-O', 'of-O', 'the-O', 'electrocardiogram-O', '.-O']
['3-O', '.-O']
['The-O', 'metabolic-O', 'responses-O', 'to-O', 'isoprenaline-B-Chemical', 'in-O', 'dogs-O', '(-O', 'an-O', 'increase-O', 'in-O', 'circulating-O', 'glucose-B-Chemical', ',-O', 'lactate-B-Chemical', 'and-O', 'free-O', 'fatty-O', 'acids-O', ')-O', 'were-O', 'all-O', 'blocked-O', 'by-O', '(-)-O', 'propranolol-B-Chemical', ',-O', 'Propranolol-B-Chemical', 'had-O', 'no-O', 'effect-O', 'on-O', 'fatty-O', 'acid-O', 'mobilization-O', 'but-O', 'significantly-O', 'reduced-O', 'the-O', 'increments-O', 'in-O', 'both-O', 'lactate-B-Chemical', 'and-O', 'glucose-B-Chemical', '.-O']
['4-O', '.-O']
['Both-O', 'isomers-O', 'of-O', 'propranolol-B-Chemical', 'possessed-O', 'similar-O', 'depressant-O', 'potency-O', 'on-O', 'isolated-O', 'atrial-O', 'muscle-O', 'taken-O', 'from-O', 'guinea-O', 'pigs-O', '.-O']
['5-O', '.-O']
['The-O', 'isomers-O', 'of-O', 'propranolol-B-Chemical', 'exhibited-O', 'similar-O', 'local-O', 'anaesthetic-O', 'potencies-O', 'on-O', 'an-O', 'isolated-O', 'frog-O', 'nerve-O', 'preparation-O', 'at-O', 'a-O', 'level-O', 'approximately-O', 'three-O', 'times-O', 'that-O', 'of-O', 'procaine-B-Chemical', '.-O']
['The-O', 'racemic-O', 'compound-O', 'was-O', 'significantly-O', 'less-O', 'potent-O', 'than-O', 'either-O', 'isomer-O', '.-O']
['6-O', '.-O']
['Both-O', 'isomers-O', 'of-O', 'propranolol-B-Chemical', 'were-O', 'capable-O', 'of-O', 'preventing-O', 'adrenaline-B-Chemical', ',-O', 'induced-O', 'cardiac-O', 'arrhythmias-B-Disease', 'in-O', 'cats-O', 'anaesthetized-O', 'with-O', 'halothane-B-Chemical', ',-O', 'but-O', 'the-O', 'mean-O', 'dose-O', 'of-O', '(-)-O', 'propranolol-B-Chemical', 'was-O', '0-O', '.-O']
['09-O', '+-O', '0-O', '.-O']
['02-O', 'mg-O', '/-O', 'kg-O', 'whereas-O', 'that-O', 'of-O', ',-O', 'propranolol-B-Chemical', 'was-O', '4-O', '.-O']
['2-O', '+-O', '1-O', '.-O']
['2-O', 'mg-O', '/-O', 'kg-O', '.-O']
['At-O', 'the-O', 'effective-O', 'dose-O', 'level-O', 'of-O', ',-O', 'propranolol-B-Chemical', 'there-O', 'was-O', 'a-O', 'significant-O', 'prolongation-O', 'of-O', 'the-O', 'PR-O', 'interval-O', 'of-O', 'the-O', 'electrocardiogram-O', '.-O']
['Blockade-O', 'of-O', 'arrhythmias-B-Disease', 'with-O', 'both-O', 'isomers-O', 'was-O', 'surmountable-O', 'by-O', 'increasing-O', 'the-O', 'dose-O', 'of-O', 'adrenaline-B-Chemical', '.-O']
['7-O', '.-O']
['Both-O', 'isomers-O', 'of-O', 'propranolol-B-Chemical', 'were-O', 'also-O', 'capable-O', 'of-O', 'reversing-O', 'ventricular-B-Disease', 'tachycardia-I-Disease', 'caused-O', 'by-O', 'ouabain-B-Chemical', 'in-O', 'anaesthetized-O', 'cats-O', 'and-O', 'dogs-O', '.-O']
['The-O', 'dose-O', 'of-O', '(-)-O', 'propranolol-B-Chemical', 'was-O', 'significantly-O', 'smaller-O', 'than-O', 'that-O', 'of-O', ',-O', 'propranolol-B-Chemical']
['Topotecan-B-Chemical', 'in-O', 'combination-O', 'with-O', 'radiotherapy-O', 'in-O', 'unresectable-O', 'glioblastoma-B-Disease', ':-O', 'a-O', 'phase-O', '2-O', 'study-O', '.-O']
['Improving-O', 'glioblastoma-B-Disease', 'multiforme-I-Disease', '(-O', 'GBM-I-Disease', ')-O', 'treatment-O', 'with-O', 'radio-O', ',-O', 'chemotherapy-O', 'remains-O', 'a-O', 'challenge-O', '.-O']
['Topotecan-B-Chemical', 'is-O', 'an-O', 'attractive-O', 'option-O', 'as-O', 'it-O', 'exhibits-O', 'growth-O', 'inhibition-O', 'of-O', 'human-O', 'glioma-B-Disease', 'as-O', 'well-O', 'as-O', 'brain-O', 'penetration-O', '.-O']
['The-O', 'present-O', 'study-O', 'assessed-O', 'the-O', 'combination-O', 'of-O', 'radiotherapy-O', '(-O', '60-O', 'Gy-O', '/-O', '30-O', 'fractions-O', '/-O', '40-O', 'days-O', ')-O', 'and-O', 'topotecan-B-Chemical', '(-O', '0-O', '.-O']
['9-O', 'mg-O', '/-O', 'm-O', '(-O', '2-O', ')/-O', 'day-O', 'on-O', 'days-O', '1-O', ',-O', '5-O', 'on-O', 'weeks-O', '1-O', ',-O', '3-O', 'and-O', '5-O', ')-O', 'in-O', '50-O', 'adults-O', 'with-O', 'histologically-O', 'proven-O', 'and-O', 'untreated-O', 'GBM-B-Disease', '.-O']
['The-O', 'incidence-O', 'of-O', 'non-O', ',-O', 'hematological-O', 'toxicities-B-Disease', 'was-O', 'low-O', 'and-O', 'grade-O', '3-O', ',-O', '4-O', 'hematological-O', 'toxicities-B-Disease', 'were-O', 'reported-O', 'in-O', '20-O', 'patients-O', '(-O', 'mainly-O', 'lymphopenia-B-Disease', 'and-O', 'neutropenia-B-Disease', ')-O', '.-O', 'Partial-O', 'response-O', 'and-O', 'stabilization-O', 'rates-O', 'were-O', '2-O', '%-O', 'and-O', '32-O', ',-O', 'respectively-O', ',-O', 'with-O', 'an-O', 'overall-O', 'time-O', 'to-O', 'progression-O', 'of-O', '12-O', 'weeks-O', '.-O']
['One-O', ',-O', 'year-O', 'overall-O', 'survival-O', '(-O', 'OS-O', ')-O', 'rate-O', 'was-O', '42-O', ',-O', 'with-O', 'a-O', 'median-O', 'OS-O', 'of-O', '40-O', 'weeks-O', '.-O']
['Topotecan-B-Chemical', 'in-O', 'combination-O', 'with-O', 'radiotherapy-O', 'was-O', 'well-O', 'tolerated-O', '.-O']
['However-O', ',-O', 'while-O', 'response-O', 'and-O', 'stabilization-O', 'concerned-O', 'one-O', ',', 'third-O', 'of-O', 'the-O', 'patients-O', ',-O', 'the-O', 'study-O', 'did-O', 'not-O', 'show-O', 'increased-O', 'benefits-O', 'in-O', 'terms-O', 'of-O', 'survival-O', 'in-O', 'patients-O', 'with-O', 'unresectable-O', 'GBM-B-Disease', '.-O']
['Long-O', ',-O', 'term-O', 'lithium-B-Chemical', 'therapy-O', 'leading-O', 'to-O', 'hyperparathyroidism-B-Disease', ':-O', 'a-O', 'case-O', 'report-O', '.-O']
['PURPOSE-O', ':-O', 'This-O', 'paper-O', 'reviews-O', 'the-O', 'effect-O', 'of-O', 'chronic-O', 'lithium-B-Chemical', 'therapy-O', 'on-O', 'serum-O', 'calcium-B-Chemical', 'level-O', 'and-O', 'parathyroid-O', 'glands-O', ',-O', 'its-O', 'pathogenesis-O', ',-O', 'and-O', 'treatment-O', 'options-O', '.-O']
['We-O', 'examined-O', 'the-O', 'case-O', 'of-O', 'a-O', 'lithium-B-Chemical', ',-O', 'treated-O', 'patient-O', 'who-O', 'had-O', 'recurrent-O', 'hypercalcemia-B-Disease', 'to-O', 'better-O', 'understand-O', 'the-O', 'disease-O', 'process-O', '.-O']
['CONCLUSION-O', ':-O', 'Primary-O', 'hyperparathyroidism-B-Disease', 'is-O', 'a-O', 'rare-O', 'but-O', 'potentially-O', 'life-O', ',-O', 'threatening-O', 'side-O', 'effect-O', 'of-O', 'long-O', ',-O', 'term-O', 'lithium-B-Chemical', 'therapy-O', '.-O']
['Careful-O', 'patient-O', 'selection-O', 'and-O', 'long-O', ',-O', 'term-O', 'follow-O', ',-O', 'up-O', 'can-O', 'reduce-O', 'morbidity-O', '.-O']
['PRACTICAL-O', 'IMPLICATIONS-O', ':-O', 'As-O', 'much-O', 'as-O', '15-O', '%-O', 'of-O', 'lithium-B-Chemical', ',-O', 'treated-O', 'patients-O', 'become-O', 'hypercalcemic-B-Disease', '.-O']
['By-O', 'routinely-O', 'monitoring-O', 'serum-O', 'calcium-B-Chemical']
['Comparison-O', 'of-O', 'laryngeal-O', 'mask-O', 'with-O', 'endotracheal-O', 'tube-O', 'for-O', 'anesthesia-O', 'in-O', 'endoscopic-O', 'sinus-O', 'surgery-O', '.-O']
['BACKGROUND-O', ':-O', 'The-O', 'purpose-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'compare-O', 'surgical-O', 'conditions-O', ',-O', 'including-O', 'the-O', 'amount-O', 'of-O', 'intraoperative-O', 'bleeding-B-Disease', 'as-O', 'well-O', 'as-O', 'intraoperative-O', 'blood-O', 'pressure-O', ',-O', 'during-O', 'functional-O', 'endoscopic-O', 'sinus-O', 'surgery-O', '(-O', 'FESS-O', ')-O', 'using-O', 'flexible-O', 'reinforced-O', 'laryngeal-O', 'mask-O', 'airway-O', '(-O', 'FRLMA-O', ')-O', 'versus-O', 'endotracheal-O', 'tube-O', '(-O', 'ETT-O', ')-O', 'in-O', 'maintaining-O', 'controlled-O', 'hypotension-B-Disease', 'anesthesia-O', 'induced-O', 'by-O', 'propofol-B-Chemical', ',-O', 'remifentanil-B-Chemical', 'total-O', 'i-O', '.-O']
['v-O', '.-O']
['anesthesia-O', '(-O', 'TIVA-O', ').-O', 'METHODS-O', ':-O', 'Sixty-O', 'normotensive-O', 'American-O', 'Society-O', 'of-O', 'Anesthesiologists-O', 'I-O', ',-O', 'II-O', 'adult-O', 'patients-O', 'undergoing-O', 'FESS-O', 'under-O', 'controlled-O', 'hypotension-B-Disease', 'anesthesia-O', 'caused-O', 'by-O', 'propofol-B-Chemical', ',-O', 'remifentanil-B-Chemical', ',-O', 'TIVA-O', 'were-O', 'randomly-O', 'assigned-O', 'into-O', 'two-O', 'groups-O', ':-O', 'group-O', 'I-O', ',-O', 'FRLMA-O', ';-O', 'group-O', 'II-O', ',-O', 'ETT-O', '.-O']
['Hemorrhage-B-Disease', 'was-O', 'measured-O', 'and-O', 'the-O', 'visibility-O', 'of-O', 'the-O', 'operative-O', 'field-O', 'was-O', 'evaluated-O', 'according-O', 'to-O', 'a-O', 'six-O', ',-O', 'point-O', 'scale-O', '.-O']
['RESULTS-O', ':-O', 'Controlled-O', 'hypotension-B-Disease', 'was-O', 'achieved-O', 'within-O', 'a-O', 'shorter-O', 'period-O', 'using-O', 'laryngeal-O', 'mask-O', 'using-O', 'lower-O', 'rates-O', 'of-O', 'remifentanil-B-Chemical', 'infusion-O', 'and-O', 'lower-O', 'total-O', 'dose-O', 'of-O', 'remifentanil-B-Chemical', '.-O']
['CONCLUSION-O', ':-O', 'In-O', 'summary-O', ',-O', 'our-O', 'results-O', 'indicate-O', 'that-O', 'airway-O', 'management-O', 'using-O', 'FRLMA-O', 'during-O', 'controlled-O', 'hypotension-B-Disease', 'anesthesia-O', 'provided-O', 'better-O', 'surgical-O', 'conditions-O', 'in-O', 'terms-O', 'of-O', 'quality-O', 'of-O', 'operative-O', 'field-O', 'and-O', 'blood-O', 'loss-O', 'and-O', 'allowed-O', 'for-O', 'convenient-O', 'induced-O', 'hypotension-B-Disease', 'with-O', 'low-O', 'doses-O', 'of-O', 'remifentanil-B-Chemical']
['Nonalcoholic-O', 'fatty-O', 'liver-B-Disease', 'disease-I-Disease', 'during-O', 'valproate-B-Chemical', 'therapy-O', '.-O']
['Valproic-B-Chemical', 'acid-I-Chemical', '(-O', 'VPA-B-Chemical', ')-O', 'is-O', 'effective-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'many-O', 'types-O', 'of-O', 'epilepsy-B-Disease', ',-O', 'but-O', 'its-O', 'use-O', 'can-O', 'be-O', 'associated-O', 'with-O', 'an-O', 'increase-O', 'in-O', 'body-O', 'weight-O', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'nonalcoholic-O', 'fatty-O', 'liver-B-Disease', 'disease-I-Disease', '(-O', 'NAFLD-B-Disease', ')-O', 'arising-O', 'in-O', 'a-O', 'child-O', 'who-O', 'developed-O', 'obesity-B-Disease', 'during-O', 'VPA-B-Chemical', 'treatment-O', '.-O']
['Laboratory-O', 'data-O', 'revealed-O', 'hyperinsulinemia-B-Disease', 'with-O', 'insulin-B-Chemical', 'resistance-O', '.-O']
['After-O', 'the-O', 'withdrawal-O', 'of-O', 'VPA-B-Chemical', 'therapy-O', ',-O', 'our-O', 'patient-O', 'showed-O', 'a-O', 'significant-O', 'weight-O', 'loss-O', ',-O', 'a-O', 'decrease-O', 'of-O', 'body-O', 'mass-O', 'index-O', ',-O', 'and-O', 'normalization-O', 'of-O', 'metabolic-O', 'and-O', 'endocrine-O', 'parameters-O', ';-O', 'moreover-O', ',-O', 'ultrasound-O', 'measurements-O', 'showed-O', 'a-O', 'complete-O', 'normalization-O', '.-O']
['The-O', 'present-O', 'case-O', 'suggests-O', 'that-O', 'obesity-B-Disease', ',-O', 'hyperinsulinemia-B-Disease', ',-O', 'insulin-O', 'resistance-B-Disease', ',-O', 'and-O', 'long-O', '--O', 'term-O', 'treatment-O', 'with-O', 'VPA-B-Chemical', 'may-O', 'be-O', 'all-O', 'associated-O', 'with-O', 'the-O', 'development-O', 'of-O', 'NAFLD-B-Disease', ';-O', 'this-O', 'side-O', 'effect-O', 'is-O', 'reversible-O', 'after-O', 'VPA-B-Chemical']
['Carbimazole-B-Chemical', 'induced-O', 'ANCA-O', 'positive-O', 'vasculitis-B-Disease', '.-O']
['Anti-thyroid-O', 'drugs-O', ',-O', 'like-O', 'carbimazole-B-Chemical', 'and-O', 'propylthiouracil-B-Chemical', '(-O', 'PTU-B-Chemical', ')-O', 'are-O', 'commonly-O', 'prescribed-O', 'for-O', 'the-O', 'treatment-O', 'of-O', 'hyperthyroidism-B-Disease', '.-O']
['One-O', 'should-O', 'be-O', 'aware-O', 'of-O', 'the-O', 'side-O', 'effects-O', 'of-O', 'antithyroid-O', 'medications-O', '.-O']
['Antineutrophil-O', 'cytoplasmic-O', 'antibody-O', '(ANCA)-O', '--associated-O', 'vasculitis-B-Disease', 'is-O', 'a-O', 'potentially-O', 'life-O', ',-O', 'threatening-O', 'adverse-O', 'effect-O', 'of-O', 'antithyroidmedications-O', '.-O']
['We-O', 'report-O', 'a-O', 'patient-O', 'with-O', 'Graves''-B-Disease', 'disease-I-Disease', 'who-O', 'developed-O', 'ANCA-B-Chemical', 'positive-O', 'carbimazole-B-Chemical', 'induced-O', 'vasculitis-B-Disease', '.-O']
['The-O', 'episode-O', 'was-O', 'characterized-O', 'by-O', 'a-O', 'vasculitic-O', 'skin-B-Disease', 'rash-I-Disease', 'associated-O', 'with-O', 'large-O', 'joint-B-Disease', 'arthritis-I-Disease', ',-O', 'pyrexia-B-Disease', 'and-O', 'parotiditis-B-Disease', 'but-O', 'no-O', 'renal-O', 'or-O', 'pulmonary-O', 'involvement-O', '.-O']
['He-O', 'was-O', 'referred-O', 'to-O', 'us-O', 'for-O', 'neurological-O', 'evaluation-O', 'because-O', 'he-O', 'had-O', 'difficulty-O', 'in-O', 'getting-O', 'up-O', 'from-O', 'squatting-O', 'position-O', 'and-O', 'was-O', 'suspected-O', 'to-O', 'have-O', 'myositis-B-Disease', '.-O']
['Carbimazole-B-Chemical', 'and-O', 'methimazole-B-Chemical', 'have-O', 'a-O', 'lower-O', 'incidence-O', 'of-O', 'reported-O', 'ANCA-B-Disease', 'positive-O', 'side-O', 'effects-O', 'than-O', 'PUT-O', '.-O']
['To-O', 'the-O', 'best-O', 'of-O', 'our-O', 'knowledge-O', 'this-O', 'is-O', 'the-O', 'first-O', 'ANCA-O', 'positive-O', 'carbimazole-B-Chemical', 'induced-O', 'vasculitis-B-Disease']
['Aspirin-B-Chemical', 'for-O', 'the-O', 'primary-O', 'prevention-O', 'of-O', 'cardiovascular-B-Disease', 'events-O', ':-O', 'an-O', 'update-O', 'of-O', 'the-O', 'evidence-O', 'for-O', 'the-O', 'U-O', '.-O']
['S-O', '.-O']
['Preventive-O', 'Services-O', 'Task-O', 'Force-O', '.-O']
['BACKGROUND-O', ':-O', 'Coronary-B-Disease', 'heart-I-Disease', 'disease-I-Disease', 'and-O', 'cerebrovascular-B-Disease', 'disease-I-Disease', 'are-O', 'leading-O', 'causes-O', 'of-O', 'death-B-Disease', 'in-O', 'the-O', 'United-O', 'States-O', '.-O']
['In-O', '2002-O', ',-O', 'the-O', 'U-O', '.-O']
['S-O', '.-O']
['Preventive-O', 'Services-O', 'Task-O', 'Force-O', '(-O', 'USPSTF-O', ')', 'strongly-O', 'recommended-O', 'that-O', 'clinicians-O', 'discuss-O', 'aspirin-B-Chemical', 'with-O', 'adults-O', 'who-O', 'are-O', 'at-O', 'increased-O', 'risk-O', 'for-O', 'coronary-B-Disease', 'heart-O', 'disease-I-Disease', '.-O']
['PURPOSE-O', ':-O', 'To-O', 'determine-O', 'the-O', 'benefits-O', 'and-O', 'harms-O', 'of-O', 'taking-O', 'aspirin-B-Chemical', 'for-O', 'the-O', 'primary-O', 'prevention-O', 'of-O', 'myocardial-B-Disease', 'infarctions-I-Disease', ',-O', 'strokes-B-Disease', ',-O', 'and-O', 'death-O', '.-O']
['DATA-O', 'SOURCES-O', ':-O', 'MEDLINE-O', 'and-O', 'Cochrane-O', 'Library-O', '(-O', 'search-O', 'dates-O', ',-O', '1-O', 'January-O', '2001-O', 'to-O', '28-O', 'August-O', '2008-O', '),', 'recent-O', 'systematic-O', 'reviews-O', ',-O', 'reference-O', 'lists-O', 'of-O', 'retrieved-O', 'articles-O', ',-O', 'and-O', 'suggestions-O', 'from-O', 'experts-O', '.-O']
['STUDY-O', 'SELECTION-O', ':-O', 'English-O', ',-O', 'language-O', 'randomized-O', ',-O', 'controlled-O', 'trials-O', '(-O', 'RCTs-O', ');-O', 'case-O', ',-O', 'control-O', 'studies-O', ';-O', 'meta-O', ',-O', 'analyses-O', ';-O', 'and-O', 'systematic-O', 'reviews-O', 'of-O', 'aspirin-B-Chemical', 'versus-O', 'control-O', 'for-O', 'the-O', 'primary-O', 'prevention-O', 'of-O', 'cardiovascular-O', 'disease-O', '(-O', 'CVD-O', ');-O', 'were-O', 'selected-O', 'to-O', 'answer-O', 'the-O', 'following-O', 'questions-O', ':-O', 'Does-O', 'aspirin-B-Chemical', 'decrease-O', 'coronary-O', 'heart-O', 'events-O', ',-O', 'strokes-O', ',-O', 'death-O', 'from-O', 'coronary-O', 'heart-O', 'events-O', 'or-O', 'stroke-O', ',-O', 'or-O', 'all-O', ',-O', 'cause-O', 'mortality-O', 'in-O', 'adults-O', 'without-O', 'known-O', 'CVD-O', '?-O', 'Does-O', 'aspirin-B-Chemical', 'increase-O', 'gastrointestinal-O', 'bleeding-O', 'or-O', 'hemorrhagic-O', 'strokes-O', '?-O', 'DATA-O', 'EXTRACTION-O', ':-O', 'All-O', 'studies-O', 'were-O', 'reviewed-O', ',-O', 'abstracted-O', ',-O', 'and-O', 'rated-O', 'for-O', 'quality-O', 'by-O', 'using-O', 'predefined-O', 'USPSTF-O', 'criteria-O', '.-O']
['DATA-O', 'SYNTHESIS-O', ':-O', 'New-O', 'evidence-O', 'from-O', '1-O', 'good-O', ',-O', 'quality-O', 'RCT-O', ',-O', '1-O', 'good-O', ',-O', 'quality-O', 'meta-O', ',-O', 'analysis-O', ',-O', 'and-O', '2-O', 'fair-O', ',-O', 'quality-O', 'subanalyses-O', 'of-O', 'RCTs-O', 'demonstrates-O', 'that-O', 'aspirin-B-Chemical', 'use-O', 'reduces-O', 'the-O', 'number-O', 'of-O', 'CVD-B-Disease', 'events-O', 'in-O', 'patients-O', 'without-O', 'known-O', 'CVD-B-Disease', '.-O']
['Men-O', 'in-O', 'these-O', 'studies-O', 'experienced-O', 'fewer-O', 'myocardial-B-Disease', 'infarctions-I-Disease', 'and-O', 'women-O', 'experienced-O', 'fewer-O', 'ischemic-B-Disease', 'strokes-I-Disease', '.-O']
['Aspirin-B-Chemical', 'does-O', 'not-O', 'seem-O', 'to-O', 'affect-O', 'CVD-B-Disease', 'mortality-O', 'or-O', 'all-O', 'cause-O', 'mortality-O', 'in-O', 'either-O', 'men-O', 'or-O', 'women-O', '.-O']
['The-O', 'use-O', 'of-O', 'aspirin-B-Chemical', 'for-O', 'primary-O', 'prevention-O', 'increases-O', 'the-O', 'risk-O', 'for-O', 'major-O', 'bleeding-B-Disease', 'events-O', ',-O', 'primarily-O', 'gastrointestinal-B-Disease', 'bleeding-B-Disease', 'events-O', ',-O', 'in-O', 'both-O', 'men-O', 'and-O', 'women-O', '.-O']
['Men-O', 'have-O', 'an-O', 'increased-O', 'risk-O', 'for-O', 'hemorrhagic-B-Disease', 'strokes-I-Disease', 'with-O', 'aspirin-B-Chemical', 'use-O', '.-O']
['A-O', 'new-O', 'RCT-O', 'and-O', 'meta-O', 'analysis-O', 'suggest-O', 'that-O', 'the-O', 'risk-O', 'for-O', 'hemorrhagic-B-Disease', 'strokes-B-Disease', 'in-O', 'women-O', 'is-O', 'not-O', 'statistically-O', 'significantly-O', 'increased-O', '.-O']
['LIMITATIONS-O', ':-O', 'New-O', 'evidence-O', 'on-O', 'aspirin-B-Chemical', 'for-O', 'the-O', 'primary-O', 'prevention-O', 'of-O', 'CVD-B-Disease', 'is-O', 'limited-O', '.-O']
['The-O', 'dose-O', 'of-O', 'aspirin-B-Chemical', 'used-O', 'in-O', 'the-O', 'RCTs-O', 'varied-O', ',-O', 'which-O', 'prevented-O', 'the-O', 'estimation-O', 'of-O', 'the-O', 'most-O', 'appropriate-O', 'dose-O', 'for-O', 'primary-O', 'prevention-O', '.-O']
['Several-O', 'of-O', 'the-O', 'RCTs-O', 'were-O', 'conducted-O', 'within-O', 'populations-O', 'of-O', 'health-O', 'professionals-O', ',-O', 'which-O', 'potentially-O', 'limits-O', 'generalizability-O', '.-O']
['CONCLUSION-O', ':-O', 'Aspirin-B-Chemical', 'reduces-O', 'the-O', 'risk-O', 'for-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'in-O', 'men-O', 'and-O', 'strokes-B-Disease', 'in-O', 'women-O', '.-O']
['Aspirin-B-Chemical', 'use-O', 'increases-O', 'the-O', 'risk-O', 'for-O', 'serious-O', 'bleeding-B-Disease']
['Reducing-O', 'harm-O', 'associated-O', 'with-O', 'anticoagulation-O', ':-O', 'practical-O', 'considerations-O', 'of-O', 'argatroban-B-Chemical', 'therapy-O', 'in-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', '.-O']
['Argatroban-B-Chemical', 'is-O', 'a-O', 'hepatically-O', 'metabolized-O', ',-O', 'direct-O', 'thrombin-O', 'inhibitor-O', 'used-O', 'for-O', 'prophylaxis-O', 'or-O', 'treatment-O', 'of-O', 'thrombosis-B-Disease', 'in-O', 'heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', '(-O', 'HIT-B-Disease', ')-O', 'and-O', 'for-O', 'patients-O', 'with-O', 'or-O', 'at-O', 'risk-O', 'of-O', 'HIT-B-Disease', 'undergoing-O', 'percutaneous-O', 'coronary-O', 'intervention-O', '(-O', 'PCI-O', ')-O', '.-O', 'The-O', 'objective-O', 'of-O', 'this-O', 'review-O', 'is-O', 'to-O', 'summarize-O', 'practical-O', 'considerations-O', 'of-O', 'argatroban-B-Chemical', 'therapy-O', 'in-O', 'HIT-B-Disease', '.-O']
['The-O', 'US-O', 'FDA-O', ',-O', 'recommended-O', 'argatroban-B-Chemical', 'dose-O', 'in-O', 'HIT-B-Disease', 'is-O', '2-O', 'microg-O', '/-O', 'kg-O', '/-O', 'min-O', '(-O', 'reduced-O', 'in-O', 'patients-O', 'with-O', 'hepatic-B-Disease', 'impairment-I-Disease', 'and-O', 'in-O', 'paediatric-O', 'patients-O', ')-O', 'adjusted-O', 'to-O', 'achieve-O', 'activated-O', 'partial-O', 'thromboplastin-O', 'times-O', '(-O', 'aPTTs-O', ')-O', '1-O', '.-O']
['5-O', ',-O', '3-O', 'times-O', 'baseline-O', '(-O', 'not-O', '>-O', '100-O', 'seconds-O', ').-O', 'Contemporary-O', 'experiences-O', 'indicate-O', 'that-O', 'reduced-O', 'doses-O', 'are-O', 'also-O', 'needed-O', 'in-O', 'patients-O', 'with-O', 'conditions-O', 'associated-O', 'with-O', 'hepatic-O', 'hypoperfusion-B-Disease', ',-O', 'e-O', '.-O']
['g-O', '.-O']
['heart-B-Disease', 'failure-I-Disease', ',-O', 'yet-O', 'are-O', 'unnecessary-O', 'for-O', 'renal-B-Disease', 'dysfunction-I-Disease', ',-O', 'adult-O', 'age-O', ',-O', 'sex-O', ',-O', 'race-O', '/-O', 'ethnicity-O', 'or-O', 'obesity-O', '.-O']
['Argatroban-B-Chemical', '0-O', '.-O']
['5-O', ',-O', '1-O', '.-O']
['2-O', 'microg-O', '/-O', 'kg-O', '/-O', 'min-O', 'typically-O', 'supports-O', 'therapeutic-O', 'aPTTs-O', '.-O']
['The-O', 'FDA-O', ',-O', 'recommended-O', 'dose-O', 'during-O', 'PCI-O', 'is-O', '25-O', 'microg-O', '/-O', 'kg-O', '/-O', 'min-O', '(-O', '350-O', 'microg-O', '/-O', 'kg-O', 'initial-O', 'bolus-O', ')-O', 'adjusted-O', 'to-O', 'achieve-O', 'activated-O', 'clotting-O', 'times-O', '(-O', 'ACTs-O', ')-O', 'of-O', '300-O', ',-O', '450-O', 'sec-O', '.-O']
['For-O', 'PCI-O', ',-O', 'argatroban-B-Chemical', 'has-O', 'not-O', 'been-O', 'investigated-O', 'in-O', 'hepatically-O', 'impaired-O', 'patients-O', ';-O', 'dose-O', 'adjustment-O', 'is-O', 'unnecessary-O', 'for-O', 'adult-O', 'age-O', ',-O', 'sex-O', ',-O', 'race-O', '/-O', 'ethnicity-O', 'or-O', 'obesity-O', ',-O', 'and-O', 'lesser-O', 'doses-O', 'may-O', 'be-O', 'adequate-O', 'with-O', 'concurrent-O', 'glycoprotein-O', 'IIb-O', '/-O', 'IIIa-O', 'inhibition-O', '.-O']
['Argatroban-B-Chemical', 'prolongs-O', 'the-O', 'International-O', 'Normalized-O', 'Ratio-O', ',-O', 'and-O', 'published-O', 'approaches-O', 'for-O', 'monitoring-O', 'the-O', 'argatroban-B-Chemical', ',-O', 'to-O', ',-O', 'warfarin-B-Chemical', 'transition-O', 'should-O', 'be-O', 'followed-O', '.-O']
['Major-O', 'bleeding-B-Disease', 'with-O', 'argatroban-B-Chemical', 'is-O', '0-O', ',-O', '10-O', '%-O', 'in-O', 'the-O', 'non-O', ',-O', 'interventional-O', 'setting-O', 'and-O', '0-O', ',-O', '5-O', '.-O']
['8-O', '%-O', 'periprocedurally-O', '.-O']
['Argatroban-B-Chemical', 'has-O', 'no-O', 'specific-O', 'antidote-O', ',-O', 'and-O', 'if-O', 'excessive-O', 'anticoagulation-O', 'occurs-O', ',-O', 'argatroban-B-Chemical', 'infusion-O', 'should-O', 'be-O', 'stopped-O', 'or-O', 'reduced-O', '.-O']
['Improved-O', 'familiarity-O', 'of-O', 'healthcare-O', 'professionals-O', 'with-O', 'argatroban-B-Chemical', 'therapy-O', 'in-O', 'HIT-B-Disease', ',-O', 'including-O', 'in-O', 'special-O', 'populations-O', 'and-O', 'during-O', 'PCI-O', ',-O', 'may-O', 'facilitate-O', 'reduction-O', 'of-O', 'harm-O', 'associated-O', 'with-O', 'HIT-B-Disease', '(-O', 'e-O', '.-O']
['g-O', '.-O']
['fewer-O', 'thromboses-B-Disease', ')-O', 'or-O', 'its-O', 'treatment-O', '(-O', 'e-O', '.-O']
['g-O', '.-O']
['fewer-O', 'argatroban-B-Chemical']
['Rhabdomyolysis-B-Disease', 'and-O', 'brain-O', 'ischemic-B-Disease', 'stroke-I-Disease', 'in-O', 'a-O', 'heroin-B-Chemical', ',-O', 'dependent-O', 'male-O', 'under-O', 'methadone-B-Chemical', 'maintenance-O', 'therapy-O', '.-O']
['OBJECTIVE-O', ':-O', 'There-O', 'are-O', 'several-O', 'complications-O', 'associated-O', 'with-O', 'heroin-B-Chemical', 'abuse-O', ',-O', 'some-O', 'of-O', 'which-O', 'are-O', 'life-O', ',-O', 'threatening-O', '.-O']
['Methadone-B-Chemical', 'may-O', 'aggravate-O', 'this-O', 'problem-O', '.-O']
['METHOD-O', ':-O', 'A-O', 'clinical-O', 'case-O', 'description-O', '.-O']
['RESULTS-O', ':-O', 'A-O', '33-O', ',-O', 'year-O', ',-O', 'old-O', 'man-O', 'presented-O', 'with-O', 'rhabdomyolysis-B-Disease', 'and-O', 'cerebral-B-Disease', 'ischemic-B-Disease', 'stroke-I-Disease', 'after-O', 'intravenous-O', 'heroin-B-Chemical', '.-O']
['He-O', 'had-O', 'used-O', 'heroin-B-Chemical', 'since-O', 'age-O', '20-O', ',-O', 'and-O', 'had-O', 'used-O', '150-O', 'mg-O', 'methadone-B-Chemical', 'daily-O', 'for-O', '6-O', 'months-O', '.-O']
['He-O', 'was-O', 'found-O', 'unconsciousness-B-Disease', 'at-O', 'home-O', 'and-O', 'was-O', 'sent-O', 'to-O', 'our-O', 'hospital-O', '.-O']
['In-O', 'the-O', 'ER-O', ',-O', 'his-O', 'opiate-B-Chemical', 'level-O', 'was-O', '4497-O', 'ng-O', '/-O', 'ml-O', '.-O']
['In-O', 'the-O', 'ICU-O', ',-O', 'we-O', 'found-O', 'rhabdomyolysis-B-Disease', ',-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', 'and-O', 'acute-B-Disease', 'respiratory-I-Disease', 'failure-I-Disease', '.-O']
['After-O', 'transfer-O', 'to-O', 'an-O', 'internal-O', 'ward-O', ',-O', 'we-O', 'noted-O', 'aphasia-B-Disease', 'and-O', 'weakness-B-Disease', 'of-O', 'his-O', 'left-O', 'limbs-O', '.-O']
['After-O', 'MRI-O', ',-O', 'we-O', 'found-O', 'cerebral-B-Disease', 'ischemic-B-Disease', 'infarction-I-Disease', '.-O']
['CONCLUSION-O', ':-O', 'Those-O', 'using-O', 'methadone-B-Chemical', 'and-O', 'heroin-B-Chemical', 'simultaneously-O', 'may-O', 'increase-O', 'risk-O', 'of-O', 'rhabdomyolysis-B-Disease', 'and-O', 'ischemic-B-Disease', 'stroke-B-Disease', '.-O']
['Patients-O', 'under-O', 'methadone-B-Chemical', 'maintenance-O', 'therapy-O', 'should-O', 'be-O', 'warned-O', 'regarding-O', 'these-O', 'serious-O', 'adverse-O', 'events-O', '.-O']
['Hypotheses-O', 'of-O', 'heroin-B-Chemical', ',-O', 'related-O', 'rhabdomyolysis-B-Disease', 'and-O', 'stroke-B-Disease', 'in-O', 'heroin-B-Chemical']
['Increased-O', 'vulnerability-O', 'to-O', '6-hydroxydopamine-B-Chemical', 'lesion-O', 'and-O', 'reduced-O', 'development-O', 'of-O', 'dyskinesias-B-Disease', 'in-O', 'mice-O', 'lacking-O', 'CB1-O', 'cannabinoid-O', 'receptors-O', '.-O']
['Motor-O', 'impairment-O', ',-O', 'dopamine-B-Chemical', '(-O', 'DA-B-Chemical', ')-O', 'neuronal-O', 'activity-O', 'and-O', 'proenkephalin-B-Chemical', '(-O', 'PENK-B-Chemical', ')-O', 'gene-O', 'expression-O', 'in-O', 'the-O', 'caudate-O', ',-O', 'putamen-O', '(-O', 'CPu-O', ')-O', 'were-O', 'measured-O', 'in-O', '6-OHDA-B-Chemical', ',-O', 'lesioned-O', 'and-O', 'treated-O', '(-O', 'L-DOPA-B-Chemical', '+-O', 'benserazide-B-Chemical', ')-O', 'CB1-O', 'KO-O', 'and-O', 'WT-O', 'mice-O', '.-O']
['A-O', 'lesion-O', 'induced-O', 'by-O', '6-OHDA-B-Chemical', 'produced-O', 'more-O', 'severe-O', 'motor-O', 'deterioration-O', 'in-O', 'CB1-O', 'KO-O', 'mice-O', 'accompanied-O', 'by-O', 'more-O', 'loss-O', 'of-O', 'DA-B-Chemical', 'neurons-O', 'and-O', 'increased-O', 'PENK-B-Chemical', 'gene-O', 'expression-O', 'in-O', 'the-O', 'CPu-O', '.-O']
['Oxidative-O', '/', 'nitrosative-O', 'and-O', 'neuroinflammatory-O', 'parameters-O', 'were-O', 'estimated-O', 'in-O', 'the-O', 'CPu-O', 'and-O', 'cingulate-O', 'cortex-O', '(-O', 'Cg-O', ')-O', 'CB1-O', 'KO-O', 'mice-O', 'exhibited-O', 'higher-O', 'MDA-B-Chemical', 'levels-O', 'and-O', 'iNOS-O', 'protein-O', 'expression-O', 'in-O', 'the-O', 'CPu-O', 'and-O', 'Cg-O', 'compared-O', 'to-O', 'WT-O', 'mice-O', '.-O']
['Treatment-O', 'with-O', 'L-DOPA-B-Chemical+benserazide-B-Chemical', '(-O', '12-O', 'weeks-O', ')-O', 'resulted-O', 'in-O', 'less-O', 'severe-O', 'dyskinesias-B-Disease', 'in-O', 'CB1-O', 'KO-O', 'than-O', 'in-O', 'WT-O', 'mice-O', '.-O']
['The-O', 'results-O', 'revealed-O', 'that-O', 'the-O', 'lack-O', 'of-O', 'cannabinoid-O', 'CB1-O', 'receptors-O', 'increased-O', 'the-O', 'severity-O', 'of-O', 'motor-O', 'impairment-O', 'and-O', 'DA-B-Chemical', 'lesion-O', ',-O', 'and-O', 'reduced-O', 'L-DOPA-B-Chemical', ',-O', 'induced-O', 'dyskinesias-O', '.-O']
['These-O', 'results-O', 'suggest-O', 'that-O', 'activation-O', 'of-O', 'CB1-O', 'receptors-O', 'offers-O', 'neuroprotection-O', 'against-O', 'dopaminergic-O', 'lesion-O', 'and-O', 'the-O', 'development-O', 'of-O', 'L-DOPA-B-Chemical', ',-O', 'induced-O', 'dyskinesias-B-Disease']
['Animal-O', 'model-O', 'of-O', 'mania-B-Disease', 'induced-O', 'by-O', 'ouabain-B-Chemical', ':-O', 'Evidence-O', 'of-O', 'oxidative-O', 'stress-O', 'in-O', 'submitochondrial-O', 'particles-O', 'of-O', 'the-O', 'rat-O', 'brain-O', '.-O']
['The-O', 'intracerebroventricular-O', '(-O', 'ICV-O', ')-O', 'administration-O', 'of-O', 'ouabain-B-Chemical', '(-O', 'a-O', 'Na-B-Chemical', ',-O', 'K-B-Chemical', ',-O', 'ATPase-O', 'inhibitor-O', ')-O', 'in-O', 'rats-O', 'has-O', 'been-O', 'suggested-O', 'to-O', 'mimic-O', 'some-O', 'symptoms-O', 'of-O', 'human-O', 'bipolar-B-Disease', 'mania-I-Disease', '.-O']
['Clinical-O', 'studies-O', 'have-O', 'shown-O', 'that-O', 'bipolar-B-Disease', 'disorder-I-Disease', 'may-O', 'be-O', 'related-O', 'to-O', 'mitochondrial-B-Disease', 'dysfunction-I-Disease', '.-O']
['Herein-O', ',-O', 'we-O', 'investigated-O', 'the-O', 'behavioral-O', 'and-O', 'biochemical-O', 'effects-O', 'induced-O', 'by-O', 'the-O', 'ICV-O', 'administration-O', 'of-O', 'ouabain-B-Chemical', 'in-O', 'rats-O', '.-O']
['To-O', 'achieve-O', 'this-O', 'aim-O', ',-O', 'the-O', 'effects-O', 'of-O', 'ouabain-B-Chemical', 'injection-O', 'immediately-O', 'after-O', 'and-O', '7-O', 'days-O', 'following-O', 'a-O', 'single-O', 'ICV-O', 'administration-O', '(-O', 'at-O', 'concentrations-O', 'of-O', '10-O', '(-O', '2-O', ')', 'and-O', '10-O', '(-O', '3-O', ')', 'M-O', ')-O', 'on-O', 'locomotion-O', 'was-O', 'measured-O', 'using-O', 'the-O', 'open-O', ',-O', 'field-O', 'test-O', '.-O']
['Additionally-O', ',-O', 'thiobarbituric-B-Chemical', 'acid-O', 'reactive-O', 'substances-O', '(-O', 'TBARSs-O', ')', 'and-O', 'superoxide-B-Chemical', 'production-O', 'were-O', 'measured-O', 'in-O', 'submitochondrial-O', 'particles-O', 'of-O', 'the-O', 'prefrontal-O', 'cortex-O', ',-O', 'hippocampus-O', ',-O', 'striatum-O', 'and-O', 'amygdala-O', '.-O']
['Our-O', 'findings-O', 'demonstrated-O', 'that-O', 'ouabain-B-Chemical', 'at-O', '10-O', '(-O', '2-O', ')', 'and-O', '10-O', '(-O', '3-O', ')', 'M-O', 'induced-O', 'hyperlocomotion-B-Disease', 'in-O', 'rats-O', ',-O', 'and-O', 'this-O', 'response-O', 'remained-O', 'up-O', 'to-O', '7-O', 'days-O', 'following-O', 'a-O', 'single-O', 'ICV-O', 'injection-O', '.-O']
['In-O', 'addition-O', ',-O', 'we-O', 'observed-O', 'that-O', 'the-O', 'persistent-O', 'increase-O', 'in-O', 'the-O', 'rat-O', 'spontaneous-O', 'locomotion-O', 'is-O', 'associated-O', 'with-O', 'increased-O', 'TBARS-B-Chemical', 'levels-O', 'and-O', 'superoxide-B-Chemical', 'generation-O', 'in-O', 'submitochondrial-O', 'particles-O', 'in-O', 'the-O', 'prefrontal-O', 'cortex-O', ',-O', 'striatum-O', 'and-O', 'amygdala-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'ouabain-B-Chemical', ',-O', 'induced-O', 'mania-B-Disease', ',-O', 'like-O', 'behavior-O', 'may-O', 'provide-O', 'a-O', 'useful-O', 'animal-O', 'model-O', 'to-O', 'test-O', 'the-O', 'hypothesis-O', 'of-O', 'the-O', 'involvement-O', 'of-O', 'oxidative-O', 'stress-O', 'in-O', 'bipolar-B-Disease', 'disorder-O']
['Intraoperative-O', 'dialysis-O', 'during-O', 'liver-O', 'transplantation-O', 'with-O', 'citrate-B-Chemical', 'dialysate-O', '.-O']
['Liver-O', 'transplantation-O', 'for-O', 'acutely-O', 'ill-O', 'patients-O', 'with-O', 'fulminant-B-Disease', 'liver-I-Disease', 'failure-I-Disease', 'carries-O', 'high-O', 'intraoperative-O', 'and-O', 'immediate-O', 'postoperative-O', 'risks-O', '.-O']
['These-O', 'are-O', 'increased-O', 'with-O', 'the-O', 'presence-O', 'of-O', 'concomitant-O', 'acute-O', 'kidney-O', 'injury-O', '(-O', 'AKI-B-Disease', ')-O', 'and-O', 'intraoperative-O', 'dialysis-O', 'is-O', 'sometimes-O', 'required-O', 'to-O', 'allow-O', 'the-O', 'transplant-O', 'to-O', 'proceed-O', '.-O']
['The-O', 'derangements-O', 'in-O', 'the-O', 'procoagulant-O', 'and-O', 'anticoagulant-O', 'pathways-O', 'during-O', 'fulminant-B-Disease', 'liver-B-Disease', 'failure-I-Disease', 'can-O', 'lead-O', 'to-O', 'difficulties-O', 'with-O', 'anticoagulation-O', 'during-O', 'dialysis-O', ',-O', 'especially-O', 'when-O', 'continued-O', 'in-O', 'the-O', 'operating-O', 'room-O', '.-O']
['Systemic-O', 'anticoagulation-O', 'is-O', 'unsafe-O', 'and-O', 'regional-O', 'citrate-B-Chemical', 'anticoagulation-O', 'in-O', 'the-O', 'absence-O', 'of-O', 'a-O', 'functional-O', 'liver-O', 'carries-O', 'the-O', 'risk-O', 'of-O', 'citrate-B-Chemical', 'toxicity-B-Disease', '.-O']
['Citrate-B-Chemical', 'dialysate-O', ',-O', 'a-O', 'new-O', 'dialysate-O', 'with-O', 'citric-B-Chemical', 'acid-B-Chemical', 'can-O', 'be-O', 'used-O', 'for-O', 'anticoagulation-O', 'in-O', 'patients-O', 'who-O', 'cannot-O', 'tolerate-O', 'heparin-B-Chemical', 'or-O', 'regional-O', 'citrate-B-Chemical', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'a-O', '40-O', ',-O', 'year-O', ',-O', 'old-O', 'female-O', 'with-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'fulminant-B-Disease', 'liver-I-Disease', 'failure-I-Disease', 'with-O', 'associated-O', 'AKI-B-Disease', 'who-O', 'underwent-O', 'intraoperative-O', 'dialytic-O', 'support-O', 'during-O', 'liver-O', 'transplantation-O', 'anticoagulated-O', 'with-O', 'citrate-B-Chemical', 'dialysate-O', 'during-O', 'the-O', 'entire-O', 'procedure-O', '.-O']
['The-O', 'patient-O', 'tolerated-O', 'the-O', 'procedure-O', 'well-O', 'without-O', 'any-O', 'signs-O', 'of-O', 'citrate-B-Chemical', 'toxicity-B-Disease', 'and-O', 'maintained-O', 'adequate-O', 'anticoagulation-O', 'for-O', 'patency-O', 'of-O', 'the-O', 'dialysis-O', 'circuit-O', '.-O']
['Citrate-B-Chemical', 'dialysate-O', 'is-O', 'a-O', 'safe-O', 'alternative-O', 'for-O', 'intradialytic-O', 'support-O', 'of-O', 'liver-O', 'transplantation-O', 'in-O', 'fulminant-B-Disease', 'liver-I-Disease', 'failure-I-Disease']
['Delirium-B-Disease', 'in-O', 'a-O', 'patient-O', 'with-O', 'toxic-O', 'flecainide-B-Chemical', 'plasma-O', 'concentrations-O', ':-O', 'the-O', 'role-O', 'of-O', 'a-O', 'pharmacokinetic-O', 'drug-O', 'interaction-O', 'with-O', 'paroxetine-B-Chemical', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'describe-O', 'a-O', 'case-O', 'of-O', 'flecainide-B-Chemical', ',-O', 'induced-O', 'delirium-B-Disease', 'associated-O', 'with-O', 'a-O', 'pharmacokinetic-O', 'drug-O', 'interaction-O', 'with-O', 'paroxetine-B-Chemical', '.-O']
['CASE-O', 'SUMMARY-O', ':-O', 'A-O', '69-O', ',-O', 'year-O', ',-O', 'old-O', 'white-O', 'female-O', 'presented-O', 'to-O', 'the-O', 'emergency-O', 'department-O', 'with-O', 'a-O', 'history-O', 'of-O', 'confusion-B-Disease', 'and-O', 'paranoia-B-Disease', 'over-O', 'the-O', 'past-O', 'several-O', 'days-O', '.-O']
['On-O', 'admission-O', 'the-O', 'patient-O', 'was-O', 'taking-O', 'carvedilol-B-Chemical', '12-O', 'mg-O', 'twice-O', 'daily-O', ',-O', 'warfarin-B-Chemical', '2-O', 'mg-O', '/-O', 'day-O', ',-O', 'folic-B-Chemical', 'acid-I-Chemical', '1-O', 'mg-O', '/-O', 'day-O', ',-O', 'levothyroxine-B-Chemical', '100-O', 'microg-O', '/-O', 'day-O', ',-O', 'pantoprazole-B-Chemical', '40-O', 'mg-O', '/-O', 'day-O', ',-O', 'paroxetine-B-Chemical', '40-O', 'mg-O', '/-O', 'day-O', ',-O', 'and-O', 'flecainide-B-Chemical', '100-O', 'mg-O', 'twice-O', 'daily-O', '.-O']
['Flecainide-B-Chemical', 'had-O', 'been-O', 'started-O', '2-O', 'weeks-O', 'prior-O', 'for-O', 'atrial-B-Disease', 'fibrillation-I-Disease', '.-O']
['Laboratory-O', 'test-O', 'findings-O', 'on-O', 'admission-O', 'were-O', 'notable-O', 'only-O', 'for-O', 'a-O', 'flecainide-B-Chemical', 'plasma-O', 'concentration-O', 'of-O', '1360-O', 'microg-O', '/-O', 'L-O', '(-O', 'reference-O', 'range-O', '200-O', ',', '1000-O', ').-O', 'A-O', 'metabolic-O', 'drug-O', 'interaction-O', 'between-O', 'flecainide-B-Chemical', 'and-O', 'paroxetine-B-Chemical', ',-O', 'which-O', 'the-O', 'patient-O', 'had-O', 'been-O', 'taking-O', 'for-O', 'more-O', 'than-O', '5-O', 'years-O', ',-O', 'was-O', 'considered-O', '.-O']
['Paroxetine-B-Chemical', 'was-O', 'discontinued-O', 'and-O', 'the-O', 'dose-O', 'of-O', 'flecainide-B-Chemical', 'was-O', 'reduced-O', 'to-O', '50-O', 'mg-O', 'twice-O', 'daily-O', '.-O']
['Her-O', 'delirium-B-Disease', 'resolved-O', '3-O', 'days-O', 'later-O', '.-O']
['DISCUSSION-O', ':-O', 'Flecainide-B-Chemical', 'and-O', 'pharmacologically-O', 'similar-O', 'agents-O', 'that-O', 'interact-O', 'with-O', 'sodium-B-Chemical', 'channels-O', 'may-O', 'cause-O', 'delirium-B-Disease', 'in-O', 'susceptible-O', 'patients-O', '.-O']
['A-O', 'MEDLINE-O', 'search-O', '(-O', '1966-O', ',-O', 'January-O', '2009-O', ')-O', 'revealed-O', 'one-O', 'in-O', 'vivo-O', 'pharmacokinetic-O', 'study-O', 'on-O', 'the-O', 'interaction-O', 'between-O', 'flecainide-B-Chemical', ',-O', 'a-O', 'CYP2D6-O', 'substrate-O', ',-O', 'and-O', 'paroxetine-B-Chemical', ',-O', 'a-O', 'CYP2D6-O', 'inhibitor-O', ',-O', 'as-O', 'well-O', 'as-O', '3-O', 'case-O', 'reports-O', 'of-O', 'flecainide-B-Chemical', ',-O', 'induced-O', 'delirium-B-Disease', '.-O']
['According-O', 'to-O', 'the-O', 'Naranjo-O', 'probability-O', 'scale-O', ',-O', 'flecainide-B-Chemical', 'was-O', 'the-O', 'probable-O', 'cause-O', 'of-O', 'the-O', 'patient-O', 'x-O', 's-O', 'delirium-B-Disease', ';-O', 'the-O', 'Horn-O', 'Drug-O', 'Interaction-O', 'Probability-O', 'Scale-O', 'indicates-O', 'a-O', 'possible-O', 'pharmacokinetic-O', 'drug-O', 'interaction-O', 'between-O', 'flecainide-B-Chemical', 'and-O', 'paroxetine-B-Chemical', '.-O']
['CONCLUSIONS-O', ':-O', 'Supratherapeutic-O', 'flecainide-B-Chemical', 'plasma-O', 'concentrations-O', 'may-O', 'cause-O', 'delirium-B-Disease', '.-O']
['Because-O', 'toxicity-B-Disease', 'may-O', 'occur-O', 'when-O', 'flecainide-B-Chemical', 'is-O', 'prescribed-O', 'with-O', 'paroxetine-B-Chemical', 'and-O', 'other-O', 'potent-O', 'CYP2D6-O', 'inhibitors-O', ',-O', 'flecainide-B-Chemical']
['Efficacy-O', 'of-O', 'everolimus-B-Chemical', '(-O', 'RAD001-B-Chemical', ')-O', 'in-O', 'patients-O', 'with-O', 'advanced-O', 'NSCLC-B-Disease', 'previously-O', 'treated-O', 'with-O', 'chemotherapy-O', 'alone-O', 'or-O', 'with-O', 'chemotherapy-O', 'and-O', 'EGFR-B-Chemical', 'inhibitors-O', '.-O']
['BACKGROUND-O', ':-O', 'Treatment-O', 'options-O', 'are-O', 'scarce-O', 'in-O', 'pretreated-O', 'advanced-O', 'non-small-cell-B-Disease', 'lung-I-Disease', 'cancer-I-Disease', '(-O', 'NSCLC-B-Disease', ')-O', 'patients-O', '.-O']
['RAD001-B-Chemical', ',-O', 'an-O', 'oral-O', 'inhibitor-O', 'of-O', 'the-O', 'mammalian-O', 'target-O', 'of-O', 'rapamycin-B-Chemical', '(-O', 'mTOR-B-Chemical', '),,-O', 'has-O', 'shown-O', 'phase-O', 'I-O', 'efficacy-O', 'in-O', 'NSCLC-B-Disease', '.-O']
['METHODS-O', ':-O', 'Stage-O', 'IIIb-O', 'or-O', 'IV-O', 'NSCLC-B-Disease', 'patients-O', ',-O', 'with-O', 'two-O', 'or-O', 'fewer-O', 'prior-O', 'chemotherapy-O', 'regimens-O', ',-O', 'one-O', 'platinum-B-Chemical', 'based-O', '(-O', 'stratum-O', '1-O', ')-O', 'or-O', 'both-O', 'chemotherapy-O', 'and-O', 'epidermal-O', 'growth-O', 'factor-O', 'receptor-O', 'tyrosine-O', 'kinase-O', 'inhibitors-O', '(-O', 'stratum-O', '2-O', ')-O', 'received-O', 'RAD001-B-Chemical', '10-O', 'mg-O', '/-O', 'day-O', 'until-O', 'progression-O', 'or-O', 'unacceptable-O', 'toxicity-O', '.-O']
['Primary-O', 'objective-O', 'was-O', 'overall-O', 'response-O', 'rate-O', '(-O', 'ORR-O', ').-O', 'Analyses-O', 'of-O', 'markers-O', 'associated-O', 'with-O', 'the-O', 'mTOR-B-Chemical', 'pathway-O', 'were-O', 'carried-O', 'out-O', 'on-O', 'archival-O', 'tumor-B-Disease', 'from-O', 'a-O', 'subgroup-O', 'using-O', 'immunohistochemistry-O', '(-O', 'IHC-O', ')-O', 'and-O', 'direct-O', 'mutation-O', 'sequencing-O', '.-O']
['RESULTS-O', ':-O', 'Eighty-O', ',-O', 'five-O', 'patients-O', 'were-O', 'enrolled-O', ',-O', '42-O', 'in-O', 'stratum-O', '1-O', 'and-O', '43-O', 'in-O', 'stratum-O', '.-O']
['ORR-O', 'was-O', '4-O', '.-O']
['7-O', '(-O', '7-O', '.-O']
['1-O', '%-O', 'stratum-O', '1-O', ';-O', '2-O', '.-O']
['3-O', '%-O', 'stratum-O', '2-O', ').-O', 'Overall-O', 'disease-B-Disease', 'control-O', 'rate-O', 'was-O', '47-O', '.-O']
['1-O', '.-O', 'Median-O', 'progression-O', ',-O', 'free-O', 'survivals-O', '(-O', 'PFSs-O', ')-O', 'were-O', '2-O', '.-O']
['6-O', '(-O', 'stratum-O', '1-O', ')-O', 'and-O', '2-O', '.-O']
['7-O', 'months-O', '(-O', 'stratum-O', '2-O', ')-O', '.-O', 'Common-O', '>-O', 'or-O', '=-O', 'grade-O', '3-O', 'events-O', 'were-O', 'fatigue-B-Disease', ',-O', 'dyspnea-B-Disease', ',-O', 'stomatitis-B-Disease', ',-O', 'anemia-B-Disease', ',-O', 'and-O', 'thrombocytopenia-B-Disease', '.-O']
['Pneumonitis-B-Disease', ',-O', 'probably-O', 'or-O', 'possibly-O', 'related-O', ',-O', 'mainly-O', 'grade-O', '1-O', '/-O', '2-O', ',-O', 'occurred-O', 'in-O', '25-O', '.-O', 'Cox-O', 'regression-O', 'analysis-O', 'of-O', 'IHC-O', 'scores-O', 'found-O', 'that-O', 'only-O', 'phospho-O', 'AKT-B-Chemical', '(-O', 'pAKT-O', ')-O', 'was-O', 'a-O', 'significant-O', 'independent-O', 'predictor-O', 'of-O', 'worse-O', 'PFS-O', '.-O']
['CONCLUSIONS-O', ':-O', 'RAD001-B-Chemical', '10-O', 'mg-O', '/-O', 'day-O', 'was-O', 'well-O', 'tolerated-O', ',-O', 'showing-O', 'modest-O', 'clinical-O', 'activity-O', 'in-O', 'pretreated-O', 'NSCLC-B-Disease', '.-O']
['Evaluation-O', 'of-O', 'RAD001-B-Chemical', 'plus-O', 'standard-O', 'therapy-O', 'for-O', 'metastatic-O', 'NSCLC-B-Disease']
['Posttransplant-O', 'anemia-B-Disease', ':-O', 'the-O', 'role-O', 'of-O', 'sirolimus-B-Chemical', '.-O']
['Posttransplant-O', 'anemia-B-Disease', 'is-O', 'a-O', 'common-O', 'problem-O', 'that-O', 'may-O', 'hinder-O', 'patients-O', 'x-O', 'quality-O', 'of-O', 'life-O', '.-O']
['It-O', 'occurs-O', 'in-O', '12-O', 'to-O', '76-O', '%-O', 'of-O', 'patients-O', ',-O', 'and-O', 'is-O', 'most-O', 'common-O', 'in-O', 'the-O', 'immediate-O', 'posttransplant-O', 'period-O', '.-O']
['A-O', 'variety-O', 'of-O', 'factors-O', 'have-O', 'been-O', 'identified-O', 'that-O', 'increase-O', 'the-O', 'risk-O', 'of-O', 'posttransplant-O', 'anemia-B-Disease', ',', 'of-O', 'which-O', 'the-O', 'level-O', 'of-O', 'renal-O', 'function-O', 'is-O', 'most-O', 'important-O', '.-O']
['Sirolimus-B-Chemical', ',-O', 'a-O', 'mammalian-O', 'target-O', 'of-O', 'rapamycin-B-Chemical', 'inhibitor-O', ',-O', 'has-O', 'been-O', 'implicated-O', 'as-O', 'playing-O', 'a-O', 'special-O', 'role-O', 'in-O', 'posttransplant-O', 'anemia-B-Disease', '.-O']
['This-O', 'review-O', 'considers-O', 'anemia-B-Disease', 'associated-O', 'with-O', 'sirolimus-B-Chemical']
['Coronary-B-Disease', 'computerized-O', 'tomography-O', 'angiography-O', 'for-O', 'rapid-O', 'discharge-O', 'of-O', 'low-O', ',', 'risk-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', '.-O']
['BACKGROUND-O', ':-O', 'Most-O', 'patients-O', 'presenting-O', 'to-O', 'emergency-O', 'departments-O', '(-O', 'EDs-O', ')-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', 'are-O', 'admitted-O', 'for-O', 'at-O', 'least-O', '12-O', 'hours-O', 'and-O', 'receive-O', 'a-O', 'x-O', 'rule-O', 'out-O', 'acute-B-Disease', 'coronary-B-Disease', 'syndrome-I-Disease', 'x-O', 'protocol-O', ',-O', 'often-O', 'with-O', 'noninvasive-O', 'testing-O', 'prior-O', 'to-O', 'discharge-O', '.-O']
['In-O', 'patients-O', 'without-O', 'cocaine-B-Chemical', 'use-O', ',-O', 'coronary-O', 'computerized-O', 'tomography-O', 'angiography-O', '(-O', 'CTA-O', ')-O', 'has-O', 'been-O', 'shown-O', 'to-O', 'be-O', 'useful-O', 'for-O', 'identifying-O', 'a-O', 'group-O', 'of-O', 'patients-O', 'at-O', 'low-O', 'risk-O', 'for-O', 'cardiac-O', 'events-O', 'who-O', 'can-O', 'be-O', 'safely-O', 'discharged-O', '.-O']
['It-O', 'is-O', 'unclear-O', 'whether-O', 'a-O', 'coronary-O', 'CTA-O', 'strategy-O', 'would-O', 'be-O', 'efficacious-O', 'in-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', ',-O', 'as-O', 'coronary-O', 'vasospasm-B-Disease', 'may-O', 'account-O', 'for-O', 'some-O', 'of-O', 'the-O', 'ischemia-I-Disease', '.-O']
['We-O', 'studied-O', 'whether-O', 'a-O', 'negative-O', 'coronary-O', 'CTA-O', 'in-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', 'could-O', 'identify-O', 'a-O', 'subset-O', 'safe-O', 'for-O', 'discharge-O', '.-O']
['METHODS-O', ':-O', 'We-O', 'prospectively-O', 'evaluated-O', 'the-O', 'safety-O', 'of-O', 'coronary-O', 'CTA-O', 'for-O', 'low-O', ',-O', 'risk-O', 'patients-O', 'who-O', 'presented-O', 'to-O', 'the-O', 'ED-O', 'with-O', 'cocaineassociated-B-Disease', 'chest-B-Disease', 'pain-I-Disease', '(-O', 'self-O', ',-O', 'reported-O', 'or-O', 'positive-O', 'urine-O', 'test-O', ').-O', 'Consecutive-O', 'patients-O', 'received-O', 'either-O', 'immediate-O', 'coronary-O', 'CTA-O', 'in-O', 'the-O', 'ED-O', '(-O', 'without-O', 'serial-O', 'markers-O', ')-O', 'or-O', 'underwent-O', 'coronary-O', 'CTA-O', 'after-O', 'a-O', 'brief-O', 'observation-O', 'period-O', 'with-O', 'serial-O', 'cardiac-O', 'marker-O', 'measurements-O', '.-O']
['Patients-O', 'with-O', 'negative-O', 'coronary-B-Disease', 'CTA-O', '(-O', 'maximal-O', 'stenosis-I-Disease', 'less-O', 'than-O', '50-O', ')-O', 'were-O', 'discharged-O', '.-O']
['The-O', 'main-O', 'outcome-O', 'was-O', '30-O', ',-O', 'day-O', 'cardiovascular-B-Disease', 'death-B-Disease', 'or-O', 'myocardial-B-Disease', 'infarction-I-Disease', '.-O']
['RESULTS-O', ':-O', 'A-O', 'total-O', 'of-O', '59-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', 'were-O', 'evaluated-O', '.-O']
['Patients-O', 'had-O', 'a-O', 'mean-O', 'age-O', 'of-O', '45-O', '.-O']
['6-O', '+-O', '6-O', '.-O']
['6-O', 'yrs-O', 'and-O', 'were-O', '86-O', '%-O', 'black-O', ',-O', '66-O', '%-O', 'male-O', '.-O']
['Seventy-O', ',-O', 'nine-O', 'percent-O', 'had-O', 'a-O', 'normal-O', 'or-O', 'nonspecific-O', 'ECG-O', 'and-O', '85-O', '%-O', 'had-O', 'a-O', 'TIMI-O', 'score-O', '<-O', '2-O', '.-O']
['Twenty-O', 'patients-O', 'received-O', 'coronary-O', 'CTA-O', 'immediately-O', 'in-O', 'the-O', 'ED-O', ',-O', '18-O', 'of-O', 'whom-O', 'were-O', 'discharged-O', 'following-O', 'CTA-O', '(-O', '90-O', ').-O', 'Thirty-O', ',-O', 'nine-O', 'received-O', 'coronary-O', 'CTA-O', 'after-O', 'a-O', 'brief-O', 'observation-O', 'period-O', ',-O', 'with-O', '37-O', 'discharged-O', 'home-O', 'following-O', 'CTA-O', '(-O', '95-O', ').-O', 'Six-O', 'patients-O', 'had-O', 'coronary-O', 'stenosis-O', '>-O', 'or-O', '=-O', '50-O', '.-O', 'During-O', 'the-O', '30-O', ',-O', 'day-O', 'follow-O', ',-O', 'up-O', 'period-O', ',-O', 'no-O', 'patients-O', 'died-O', 'of-O', 'a-O', 'cardiovascular-O', 'event-O', '(-O', '0-O', ';-O', '95-O', '%-O', 'CI-O', ',-O', '0-O', ',-O', '6-O', '.-O']
['1-O', ')-O', 'and-O', 'no-O', 'patient-O', 'sustained-O', 'a-O', 'nonfatal-O', 'myocardial-B-Disease', 'infarction-I-Disease', '(-O', '0-O', ';-O', '95-O', '%-O', 'CI-O', ',-O', '0-O', ',-O', '6-O', '.-O']
['1-O', ').-O', 'CONCLUSIONS-O', ':-O', 'Although-O', 'cocaine-B-Chemical', ',-O', 'associated-O', 'myocardial-B-Disease', 'ischemia-I-Disease', 'can-O', 'result-O', 'from-O', 'coronary-B-Disease', 'vasoconstriction-O', ',-O', 'patients-O', 'with-O', 'cocaine-B-Chemical', 'associated-O', 'chest-B-Disease', 'pain-I-Disease', ',-O', 'a-O', 'non-O', ',-O', 'ischemic-O']
['Late-O', 'fulminant-O', 'posterior-O', 'reversible-O', 'encephalopathy-B-Disease', 'syndrome-O', 'after-O', 'liver-O', 'transplant-O', '.-O']
['OBJECTIVES-O', ':-O', 'Posterior-B-Disease', 'leukoencephalopathy-B-Disease', 'due-O', 'to-O', 'calcineurin-O', ',-O', 'inhibitor-O', ',-O', 'related-O', 'neurotoxicity-O', 'is-O', 'a-O', 'rare-O', 'but-O', 'severe-O', 'complication-O', 'that-O', 'results-O', 'from-O', 'treatment-O', 'with-O', 'immunosuppressive-O', 'agents-O', '(-O', 'primarily-O', 'those-O', 'administered-O', 'after-O', 'a-O', 'liver-O', 'or-O', 'kidney-O', 'transplant-O', ').-O', 'The-O', 'pathophysiologic-O', 'mechanisms-O', 'of-O', 'that-O', 'disorder-O', 'remain-O', 'unknown-O', '.-O']
['CASE-O', ':-O', 'We-O', 'report-O', 'the-O', 'case-O', 'of-O', 'a-O', '46-O', ',-O', 'year-O', ',-O', 'old-O', 'woman-O', 'who-O', 'received-O', 'a-O', 'liver-O', 'transplant-O', 'in-O', 'our-O', 'center-O', 'as-O', 'treatment-O', 'for-O', 'alcoholic-O', 'cirrhosis-B-Disease', 'and-O', 'in-O', 'whom-O', 'either-O', 'a-O', 'fulminant-O', 'course-O', 'of-O', 'posterior-O', 'leukoencephalopathy-B-Disease', 'or-O', 'posterior-O', 'reversible-O', 'encephalopathy-B-Disease', 'syndrome-O', 'developed-O', '110-O', 'days-O', 'after-O', 'transplant-O', '.-O']
['After-O', 'an-O', 'initially-O', 'uneventful-O', 'course-O', 'after-O', 'the-O', 'transplant-O', ',-O', 'the-O', 'patient-O', 'rapidly-O', 'fell-O', 'into-O', 'deep-O', 'coma-B-Disease', '.-O']
['RESULTS-O', ':-O', 'Cerebral-O', 'MRI-O', 'scan-O', 'showed-O', 'typical-O', 'signs-O', 'of-O', 'enhancement-O', 'in-O', 'the-O', 'pontine-O', 'and-O', 'posterior-O', 'regions-O', '.-O']
['Switching-O', 'the-O', 'immunosuppressive-O', 'regimen-O', 'from-O', 'tacrolimus-B-Chemical', 'to-O', 'cyclosporine-B-Chemical', 'did-O', 'not-O', 'improve-O', 'the-O', 'clinical-O', 'situation-O', '.-O']
['The-O', 'termination-O', 'of-O', 'treatment-O', 'with-O', 'any-O', 'calcineurin-O', 'inhibitor-O', 'resulted-O', 'in-O', 'a-O', 'complete-O', 'resolution-O', 'of-O', 'that-O', 'complication-O', '.-O']
['CONCLUSIONS-O', ':-O', 'Posterior-O', 'reversible-O', 'encephalopathy-B-Disease', 'syndrome-O']
['Prolonged-O', 'hypothermia-B-Disease', 'as-O', 'a-O', 'bridge-O', 'to-O', 'recovery-O', 'for-O', 'cerebral-B-Disease', 'edema-I-Disease', 'and-O', 'intracranial-B-Disease', 'hypertension-I-Disease', 'associated-O', 'with-O', 'fulminant-O', 'hepatic-B-Disease', 'failure-I-Disease', '.-O']
['BACKGROUND-O', ':-O', 'To-O', 'review-O', 'evidence-O', ',-O', 'based-O', 'treatment-O', 'options-O', 'in-O', 'patients-O', 'with-O', 'cerebral-B-Disease', 'edema-I-Disease', 'complicating-O', 'fulminant-B-Disease', 'hepatic-B-Disease', 'failure-I-Disease', '(-O', 'FHF-O', ')-O', 'and-O', 'discuss-O', 'the-O', 'potential-O', 'applications-O', 'of-O', 'hypothermia-B-Chemical', '.-O']
['METHOD-O', ':-O', 'Case-O', ',-O', 'based-O', 'observations-O', 'from-O', 'a-O', 'medical-O', 'intensive-O', 'care-O', 'unit-O', '(-O', 'MICU-O', ')-O', 'in-O', 'a-O', 'tertiary-O', 'care-O', 'facility-O', 'in-O', 'a-O', '27-O', ',-O', 'year-O', ',-O', 'old-O', 'female-O', 'with-O', 'FHF-B-Disease', 'from-O', 'acetaminophen-B-Chemical', 'and-O', 'resultant-O', 'cerebral-B-Disease', 'edema-I-Disease', '.-O']
['RESULTS-O', ':-O', 'Our-O', 'patient-O', 'was-O', 'admitted-O', 'to-O', 'the-O', 'MICU-O', 'after-O', 'being-O', 'found-O', 'unresponsive-O', 'with-O', 'presumed-O', 'toxicity-B-Disease', 'from-O', 'acetaminophen-B-Chemical', 'which-O', 'was-O', 'ingested-O', 'over-O', 'a-O', '2-O', ',-O', 'day-O', 'period-O', '.-O']
['The-O', 'patient-O', 'had-O', 'depressed-B-Disease', 'of-O', 'mental-O', 'status-O', 'lasting-O', 'at-O', 'least-O', '24-O', 'h-O', 'prior-O', 'to-O', 'admission-O', '.-O']
['Initial-O', 'evaluation-O', 'confirmed-O', 'FHF-B-Disease', 'from-O', 'acetaminophen-B-Chemical', 'and-O', 'cerebral-B-Disease', 'edema-I-Disease', '.-O']
['The-O', 'patient-O', 'was-O', 'treated-O', 'with-O', 'hyperosmolar-O', 'therapy-O', ',-O', 'hyperventilation-O', ',-O', 'sedation-O', ',-O', 'and-O', 'chemical-O', 'paralysis-B-Disease', '.-O']
['Her-O', 'intracranial-B-Disease', 'pressure-O', 'remained-O', 'elevated-O', 'despite-O', 'maximal-O', 'medical-O', 'therapy-O', '.-O']
['We-O', 'then-O', 'initiated-O', 'therapeutic-O', 'hypothermia-B-Disease', 'which-O', 'was-O', 'continued-O', 'for-O', '5-O', 'days-O', '.-O']
['At-O', 're-O', ',-O', 'warming-O', ',-O', 'patient-O', 'had-O', 'resolution-O', 'of-O', 'her-O', 'cerebral-B-Disease', 'edema-I-Disease', 'and-O', 'intracranial-B-Disease', 'hypertension-I-Disease', '.-O']
['At-O', 'discharge-O', ',-O', 'she-O', 'had-O', 'complete-O', 'recovery-O', 'of-O', 'neurological-O', 'and-O', 'hepatic-O', 'functions-O', '.-O']
['CONCLUSION-O', ':-O', 'In-O', 'patients-O', 'with-O', 'FHF-B-Disease', 'and-O', 'cerebral-B-Disease', 'edema-I-Disease', 'from-O', 'acetaminophen-B-Chemical', 'overdose-B-Disease', ',-O', 'prolonged-O', 'therapeutic-O', 'hypothermia-O', 'could-O', 'potentially-O', 'be-O', 'used-O', 'as-O', 'a-O', 'life-O', 'saving-O', 'therapy-O', 'and-O', 'a-O', 'bridge-O', 'to-O', 'hepatic-O', 'and-O', 'neurological-O', 'recovery-O', '.-O']
['A-O', 'clinical-O', 'trial-O', 'of-O', 'hypothermia-B-Disease']
['Binasal-O', 'visual-B-Disease', 'field-O', 'defects-I-Disease', 'are-O', 'not-O', 'specific-O', 'to-O', 'vigabatrin-B-Chemical', '.-O']
['This-O', 'study-O', 'investigated-O', 'the-O', 'visual-B-Disease', 'defects-I-Disease', 'associated-O', 'with-O', 'the-O', 'antiepileptic-O', 'drug-O', 'vigabatrin-B-Chemical', '(-O', 'VGB-B-Chemical', ')-O', '.', 'Two-O', 'hundred-O', 'four-O', 'people-O', 'with-O', 'epilepsy-B-Disease', 'were-O', 'grouped-O', 'on-O', 'the-O', 'basis-O', 'of-O', 'antiepileptic-O', 'drug-O', 'therapy-O', '(-O', 'current-O', ',', 'previous-O', ',', 'or-O', 'no-O', 'exposure-O', 'to-O', 'VGB-B-Chemical', ')-O', '.', 'Groups-O', 'were-O', 'matched-O', 'with-O', 'respect-O', 'to-O', 'age-O', ',', 'gender-O', ',', 'and-O', 'seizure-B-Disease', 'frequency-O', '.-O']
['All-O', 'patients-O', 'underwent-O', 'objective-O', 'assessment-O', 'of-O', 'electrophysiological-O', 'function-O', '(-O', 'wide-O', ',-O', 'field-O', 'multifocal-O', 'electroretinography-O', ')-O', 'and-O', 'conventional-O', 'visual-O', 'field-O', 'testing-O', '(-O', 'static-O', 'perimetry-O', ').-O', 'Bilateral-O', 'visual-O', 'field-O', 'constriction-O', 'was-O', 'observed-O', 'in-O', '59-O', '%-O', 'of-O', 'patients-O', 'currently-O', 'taking-O', 'VGB-B-Chemical', ',-O', '43-O', '%-O', 'of-O', 'patients-O', 'who-O', 'previously-O', 'took-O', 'VGB-B-Chemical', ',-O', 'and-O', '24-O', '%-O', 'of-O', 'patients-O', 'with-O', 'no-O', 'exposure-O', 'to-O', 'VGB-B-Chemical', '.-O']
['Assessment-O', 'of-O', 'retinal-O', 'function-O', 'revealed-O', 'abnormal-O', 'responses-O', 'in-O', '48-O', '%-O', 'of-O', 'current-O', 'VGB-B-Chemical', 'users-O', 'and-O', '22-O', '%-O', 'of-O', 'prior-O', 'VGB-B-Chemical', 'users-O', ',-O', 'but-O', 'in-O', 'none-O', 'of-O', 'the-O', 'patients-O', 'without-O', 'previous-O', 'exposure-O', 'to-O', 'VGB-B-Chemical', '.-O']
['Bilateral-O', 'visual-B-Disease', 'field-O', 'abnormalities-I-Disease', 'are-O', 'common-O', 'in-O', 'the-O', 'treated-O', 'epilepsy-B-Disease', 'population-O', ',-O', 'irrespective-O', 'of-O', 'drug-O', 'history-O', '.-O']
['Assessment-O', 'by-O', 'conventional-O', 'static-O', 'perimetry-O', 'may-O', 'neither-O', 'be-O', 'sufficiently-O', 'sensitive-O', 'nor-O', 'specific-O', 'to-O', 'reliably-O', 'identify-O', 'retinal-B-Disease', 'toxicity-I-Disease', 'associated-O', 'with-O', 'VGB-B-Chemical']
['Smoking-B-Chemical', 'of-O', 'crack-B-Chemical', 'cocaine-B-Chemical', 'as-O', 'a-O', 'risk-O', 'factor-O', 'for-O', 'HIV-B-Disease', 'infection-I-Disease', 'among-O', 'people-O', 'who-O', 'use-O', 'injection-O', 'drugs-O', '.-O']
['BACKGROUND-O', ':-O', 'Little-O', 'is-O', 'known-O', 'about-O', 'the-O', 'possible-O', 'role-O', 'that-O', 'smoking-B-Chemical', 'crack-B-Chemical', 'cocaine-B-Chemical', 'has-O', 'on-O', 'the-O', 'incidence-O', 'of-O', 'HIV-B-Disease', 'infection-I-Disease', '.-O']
['Given-O', 'the-O', 'increasing-O', 'use-O', 'of-O', 'crack-B-Chemical', 'cocaine-B-Chemical', ',-O', 'we-O', 'sought-O', 'to-O', 'examine-O', 'whether-O', 'use-O', 'of-O', 'this-O', 'illicit-O', 'drug-O', 'has-O', 'become-O', 'a-O', 'risk-O', 'factor-O', 'for-O', 'HIV-B-Disease', 'infection-I-Disease', '.-O']
['METHODS-O', ':-O', 'We-O', 'included-O', 'data-O', 'from-O', 'people-O', 'participating-O', 'in-O', 'the-O', 'Vancouver-O', 'Injection-O', 'Drug-O', 'Users-O', 'Study-O', 'who-O', 'reported-O', 'injecting-O', 'illicit-O', 'drugs-O', 'at-O', 'least-O', 'once-O', 'in-O', 'the-O', 'month-O', 'before-O', 'enrolment-O', ',-O', 'lived-O', 'in-O', 'the-O', 'greater-O', 'Vancouver-O', 'area-O', ',-O', 'were-O', 'HIV-B-Disease', ',-O', 'negative-O', 'at-O', 'enrolment-O', 'and-O', 'completed-O', 'at-O', 'least-O', '1-O', 'follow-O', '-O', 'up-O', 'study-O', 'visit-O', '.-O']
['To-O', 'determine-O', 'whether-O', 'the-O', 'risk-O', 'of-O', 'HIV-B-Disease', 'seroconversion-O', 'among-O', 'daily-O', 'smokers-O', 'of-O', 'crack-O', 'cocaine-B-Chemical', 'changed-O', 'over-O', 'time-O', ',-O', 'we-O', 'used-O', 'Cox-O', 'proportional-O', 'hazards-O', 'regression-O', 'and-O', 'divided-O', 'the-O', 'study-O', 'into-O', '3-O', 'periods-O', ':-O', 'May-O', '1-O', ',-O', '1996-O', ',-O', 'Nov-O', '.-O']
['30-O', ',-O', '1999-O', '(-O', 'period-O', '1-O', ')-O', ',', 'Dec-O', '.-O']
['1-O', ',-O', '1999-O', ',-O', 'Nov-O', '.-O']
['30-O', ',-O', '2002-O', '(-O', 'period-O', '2-O', ')-O', ',-O', 'and-O', 'Dec-O', '.-O']
['1-O', ',-O', '2002-O', ',-O', 'Dec-O', '.-O']
['30-O', ',-O', '2005-O', '(-O', 'period-O', '3-O', ')-O', '.-O', 'RESULTS-O', ':-O', 'Overall-O', ',-O', '1048-O', 'eligible-O', 'injection-O', 'drug-O', 'users-O', 'were-O', 'included-O', 'in-O', 'our-O', 'study-O', '.-O']
['Of-O', 'these-O', ',-O', '137-O', 'acquired-O', 'HIV-B-Disease', 'infection-I-Disease', 'during-O', 'follow-O', ',-O', 'up-O', '.-O']
['The-O', 'mean-O', 'proportion-O', 'of-O', 'participants-O', 'who-O', 'reported-O', 'daily-O', 'smoking-B-Chemical', 'of-O', 'crack-B-Chemical', 'cocaine-B-Chemical', 'increased-O', 'from-O', '11-O', '.-O']
['6-O', '%-O', 'in-O', 'period-O', '1-O', 'to-O', '39-O', '.-O']
['7-O', '%-O', 'in-O', 'period-O', '3-O', '.-O']
['After-O', 'adjusting-O', 'for-O', 'potential-O', 'confounders-O', ',-O', 'we-O', 'found-O', 'that-O', 'the-O', 'risk-O', 'of-O', 'HIV-B-Disease', 'seroconversion-I-Disease', 'among-O', 'participants-O', 'who-O', 'were-O', 'daily-O', 'smokers-O', 'of-O', 'crack-O', 'cocaine-B-Chemical', 'increased-O', 'over-O', 'time-O', '(-O', 'period-O', '1-O', ':-O', 'hazard-O', 'ratio-O', '[', 'HR-O', ']-O', '1-O', '.-O']
['03-O', ',-O', '95-O', '%-O', 'confidence-O', 'interval-O', '[', 'CI-O', ']-O', '0-O', '.-O']
['57-O', ',-O', '1-O', '.-O']
['85-O', ';-O', 'period-O', '2-O', ':-O', 'HR-O', '1-O', '.-O']
['68-O', ',-O', '95-O', '%-O', 'CI-O', '1-O', '.-O']
['01-O', ',-O', '2-O', '.-O']
['80-O', ';-O', 'and-O', 'period-O', '3-O', ':-O', 'HR-O', '2-O', '.-O']
['74-O', ',-O', '95-O', '%-O', 'CI-O', '1-O', '.-O']
['06-O', ',-O', '7-O', '.-O']
['11-O', ').-O', 'INTERPRETATION-O', ':-O', 'Smoking-O', 'of-O', 'crack-B-Chemical', 'cocaine-B-Chemical', 'was-O', 'found-O', 'to-O', 'be-O', 'an-O', 'independent-O', 'risk-O', 'factor-O', 'for-O', 'HIV-B-Disease', 'seroconversion-O', 'among-O', 'people-O', 'who-O', 'were-O', 'injection-O', 'drug-O', 'users-O', '.-O']
['This-O', 'finding-O', 'points-O', 'to-O', 'the-O', 'urgent-O', 'need-O', 'for-O', 'evidence-O', ',-O', 'based-O', 'public-O', 'health-O', 'initiatives-O', 'targeted-O', 'at-O', 'people-O', 'who-O', 'smoke-O', 'crack-O', 'cocaine-B-Chemical']
['Fluoxetine-B-Chemical', 'improves-O', 'the-O', 'memory-O', 'deficits-I-Disease', 'caused-O', 'by-O', 'the-O', 'chemotherapy-O', 'agent-O', '5-fluorouracil-B-Chemical', '.-O']
['Cancer-B-Disease', 'patients-O', 'who-O', 'have-O', 'been-O', 'treated-O', 'with-O', 'systemic-O', 'adjuvant-O', 'chemotherapy-O', 'have-O', 'described-O', 'experiencing-O', 'deteriorations-O', 'in-O', 'cognition-O', '.-O']
['A-O', 'widely-O', 'used-O', 'chemotherapeutic-O', 'agent-O', ',-O', '5-fluorouracil-B-Chemical', '(-O', '5-FU-B-Chemical', ')-O', 'readily-O', 'crosses-O', 'the-O', 'blood-O', ',-O', 'brain-O', 'barrier-O', 'and-O', 'so-O', 'could-O', 'have-O', 'a-O', 'direct-O', 'effect-O', 'on-O', 'brain-O', 'function-O', '.-O']
['In-O', 'particular-O', 'this-O', 'anti-O', 'mitotic-O', 'drug-O', 'could-O', 'reduce-O', 'cell-O', 'proliferation-O', 'in-O', 'the-O', 'neurogenic-O', 'regions-O', 'of-O', 'the-O', 'adult-O', 'brain-O', '.-O']
['In-O', 'contrast-O', 'reports-O', 'indicate-O', 'that-O', 'hippocampal-O', 'dependent-O', 'neurogenesis-O', 'and-O', 'cognition-O', 'are-O', 'enhanced-O', 'by-O', 'the-O', 'SSRI-B-Chemical', 'antidepressant-O', 'Fluoxetine-B-Chemical', '.-O']
['In-O', 'this-O', 'investigation-O', 'the-O', 'behavioural-O', 'effects-O', 'of-O', 'chronic-O', '(-O', 'two-O', 'week-O', ')-O', 'treatment-O', 'with-O', '5-FU-B-Chemical', 'and-O', '(-O', 'three-O', 'weeks-O', ')-O', 'with-O', 'Fluoxetine-B-Chemical', 'either-O', 'separately-O', 'or-O', 'in-O', 'combination-O', 'with-O', '5-FU-B-Chemical', 'were-O', 'tested-O', 'on-O', 'adult-O', 'Lister-O', 'hooded-O', 'rats-O', '.-O']
['Behavioural-O', 'effects-O', 'were-O', 'tested-O', 'using-O', 'a-O', 'context-O', 'dependent-O', 'conditioned-O', 'emotional-O', 'response-O', 'test-O', '(-O', 'CER-O', ')-O', 'which-O', 'showed-O', 'that-O', 'animals-O', 'treated-O', 'with-O', '5-FU-B-Chemical', 'had-O', 'a-O', 'significant-O', 'reduction-O', 'in-O', 'freezing-O', 'time-O', 'compared-O', 'to-O', 'controls-O', '.-O']
['A-O', 'separate-O', 'group-O', 'of-O', 'animals-O', 'was-O', 'tested-O', 'using-O', 'a-O', 'hippocampal-O', 'dependent-O', 'spatial-O', 'working-O', 'memory-O', 'test-O', ',-O', 'the-O', 'object-O', 'location-O', 'recognition-O', 'test-O', '(-O', 'OLR-O', ').-O', 'Animals-O', 'treated-O', 'only-O', 'with-O', '5-FU-B-Chemical', 'showed-O', 'significant-O', 'deficits-O', 'in-O', 'their-O', 'ability-O', 'to-O', 'carry-O', 'out-O', 'the-O', 'OLR-O', 'task-O', 'but-O', 'co-O', 'administration-O', 'of-O', 'Fluoxetine-B-Chemical', 'improved-O', 'their-O', 'performance-O', '.-O']
['5-FU-B-Chemical', 'chemotherapy-O', 'caused-O', 'a-O', 'significant-O', 'reduction-O', 'in-O', 'the-O', 'number-O', 'of-O', 'proliferating-O', 'cells-O', 'in-O', 'the-O', 'sub-O', 'granular-O', 'zone-O', 'of-O', 'the-O', 'dentate-O', 'gyrus-O', 'compared-O', 'to-O', 'controls-O', '.-O']
['This-O', 'reduction-O', 'was-O', 'eliminated-O', 'when-O', 'Fluoxetine-B-Chemical', 'was-O', 'co-O', 'administered-O', 'with-O', '5-FU-B-Chemical', '.-O']
['Fluoxetine-B-Chemical', 'on-O', 'its-O', 'own-O', 'had-O', 'no-O', 'effect-O', 'on-O', 'proliferating-O', 'cell-O', 'number-O', 'or-O', 'behaviour-O', '.-O']
['These-O', 'findings-O', 'suggest-O', 'that-O', '5-FU-B-Chemical', 'can-O', 'negatively-O', 'affect-O', 'both-O', 'cell-O', 'proliferation-O', 'and-O', 'hippocampal-O', 'dependent-O', 'working-O', 'memory-O', 'and-O', 'that-O', 'these-O', 'deficits-O', 'can-O', 'be-O', 'reversed-O', 'by-O', 'the-O', 'simultaneous-O', 'administration-O', 'of-O', 'the-O', 'antidepressant-O', 'Fluoxetine-B-Chemical']
['Liver-O', ',-O', 'specific-O', 'ablation-O', 'of-O', 'integrin-B-Chemical', ',-O', 'linked-O', 'kinase-O', 'in-O', 'mice-O', 'results-O', 'in-O', 'enhanced-O', 'and-O', 'prolonged-O', 'cell-O', 'proliferation-O', 'and-O', 'hepatomegaly-B-Disease', 'after-O', 'phenobarbital-B-Chemical', 'administration-O', '.-O']
['We-O', 'have-O', 'recently-O', 'demonstrated-O', 'that-O', 'disruption-O', 'of-O', 'extracellular-O', 'matrix-O', '(-O', 'ECM-O', ')-O', '/-O', 'integrin-O', 'signaling-O', 'via-O', 'elimination-O', 'of-O', 'integrin-O', ',-O', 'linked-O', 'kinase-O', '(-O', 'ILK-O', ')-O', 'in-O', 'hepatocytes-O', 'interferes-O', 'with-O', 'signals-O', 'leading-O', 'to-O', 'termination-O', 'of-O', 'liver-O', 'regeneration-O', '.-O']
['This-O', 'study-O', 'investigates-O', 'the-O', 'role-O', 'of-O', 'ILK-O', 'in-O', 'liver-O', 'enlargement-I-Disease', 'induced-O', 'by-O', 'phenobarbital-B-Chemical', '(-O', 'PB-O', ').-O', 'Wild-O', ',-O', 'type-O', '(-O', 'WT-O', ').-O', 'and-O', 'ILK-O', ':-O', 'liver-O', '-/-O', 'mice-O', 'were-O', 'given-O', 'PB-O', '(-O', '0-O', ').-O']
['1-O', '%-O', 'in-O', 'drinking-O', 'water-O', ')-O', 'for-O', '10-O', 'days-O', '.-O']
['Livers-O', 'were-O', 'harvested-O', 'on-O', '2-O', ',-O', '5-O', ',-O', 'and-O', '10-O', 'days-O', 'during-O', 'PB-B-Chemical', 'administration-O', '.-O']
['In-O', 'the-O', 'hepatocyte-O', ',-O', 'specific-O', 'ILK-O', '/', 'liver-O', '-/-O', 'mice-O', ',-O', 'the-O', 'liver-O', ':-O', 'body-O', 'weight-O', 'ratio-O', 'was-O', 'more-O', 'than-O', 'double-O', 'as-O', 'compared-O', 'to-O', '0-O', 'h-O', 'at-O', 'day-O', '2-O', '(-O', '2-O', '.-O']
['5-O', 'times-O', ')-O', 'while-O', 'at-O', 'days-O', '5-O', 'and-O', '10-O', ',-O', 'it-O', 'was-O', 'enlarged-O', 'three-O', 'times-O', '.-O']
['In-O', 'the-O', 'WT-O', 'mice-O', ',-O', 'the-O', 'increase-O', 'was-O', 'as-O', 'expected-O', 'from-O', 'previous-O', 'literature-O', '(-O', '1-O', '.-O']
['8-O', 'times-O', ')-O', 'and-O', 'seems-O', 'to-O', 'have-O', 'leveled-O', 'off-O', 'after-O', 'day-O', '2-O', '.-O']
['There-O', 'were-O', 'slightly-O', 'increased-O', 'proliferating-O', 'cell-O', 'nuclear-O', 'antigen-O', ',-O', 'positive-O', 'cells-O', 'in-O', 'the-O', 'ILK-B-Chemical', '/', 'liver-O', '-/-O', 'animals-O', 'at-O', 'day-O', '2-O', 'as-O', 'compared-O', 'to-O', 'WT-O', 'after-O', 'PB-B-Chemical', 'administration-O', '.-O']
['In-O', 'the-O', 'WT-O', 'animals-O', ',-O', 'the-O', 'proliferative-O', 'response-O', 'had-O', 'come-O', 'back-O', 'to-O', 'normal-O', 'by-O', 'days-O', '5-O', 'and-O', '10-O', '.-O']
['Hepatocytes-O', 'of-O', 'the-O', 'ILK-O', '/', 'liver-O', '-/-O', 'mice-O', 'continued-O', 'to-O', 'proliferate-O', 'up-O', 'until-O', 'day-O', '10-O', '.-O']
['ILK-O', '/-O', 'liver-O', '-/-O', 'mice-O', 'also-O', 'showed-O', 'increased-O', 'expression-O', 'of-O', 'key-O', 'genes-O', 'involved-O', 'in-O', 'hepatocyte-O', 'proliferation-O', 'at-O', 'different-O', 'time-O', 'points-O', 'during-O', 'PB-B-Chemical', 'administration-O', '.-O']
['In-O', 'summary-O', ',-O', 'ECM-O', 'proteins-O', 'communicate-O', 'with-O', 'the-O', 'signaling-O', 'machinery-O', 'of-O', 'dividing-O', 'cells-O', 'via-O', 'ILK-O', 'to-O', 'regulate-O', 'hepatocyte-O', 'proliferation-O', 'and-O', 'termination-O', 'of-O', 'the-O', 'proliferative-O', 'response-O', '.-O']
['Lack-O', 'of-O', 'ILK-O', 'in-O', 'the-O', 'hepatocytes-O', 'imparts-O', 'prolonged-O', 'proliferative-O', 'response-O', 'not-O', 'only-O', 'to-O', 'stimuli-O', 'related-O', 'to-O', 'liver-O', 'regeneration-O', 'but-O', 'also-O', 'to-O', 'xenobiotic-O', 'chemical-O', 'mitogens-O', ',-O', 'such-O', 'as-O', 'PB-B-Chemical']
['Decreased-O', 'Expression-O', 'of-O', 'Na-B-Chemical', '/-O', 'K-B-Chemical', ',-O', 'ATPase-O', ',-O', 'NHE3-O', ',-O', 'NBC1-O', ',-O', 'AQP1-O', 'and-O', 'OAT-O', 'in-O', 'Gentamicin-B-Chemical', ',-O', 'induced-O', 'Nephropathy-B-Disease', '.-O']
['The-O', 'present-O', 'study-O', 'was-O', 'aimed-O', 'to-O', 'determine-O', 'whether-O', 'there-O', 'is-O', 'an-O', 'altered-O', 'regulation-O', 'of-O', 'tubular-O', 'transporters-O', 'in-O', 'gentamicin-B-Chemical', ',-O', 'induced-O', 'nephropathy-B-Disease', '.-O']
['Sprague-O', ',-O', 'Dawley-O', 'male-O', 'rats-O', '(-O', '200-O', '~O', '250-O', 'g-O', ')-O', 'were-O', 'subcutaneously-O', 'injected-O', 'with-O', 'gentamicin-B-Chemical', '(-O', '100-O', 'mg-O', '/-O', 'kg-O', 'per-O', 'day-O', ')-O', 'for-O', '7-O', 'days-O', ',-O', 'and-O', 'the-O', 'expression-O', 'of-O', 'tubular-O', 'transporters-O', 'was-O', 'determined-O', 'by-O', 'immunoblotting-O', 'and-O', 'immunohistochemistry-O', '.-O']
['The-O', 'mRNA-O', 'and-O', 'protein-O', 'expression-O', 'of-O', 'OAT-O', 'was-O', 'also-O', 'determined-O', '.-O']
['Gentamicin-B-Chemical', ',-O', 'treated-O', 'rats-O', 'exhibited-O', 'significantly-O', 'decreased-O', 'creatinine-B-Chemical', 'clearance-O', 'along-O', 'with-O', 'increased-O', 'plasma-O', 'creatinine-B-Chemical', 'levels-O', '.-O']
['Accordingly-O', ',-O', 'the-O', 'fractional-O', 'excretion-O', 'of-O', 'sodium-B-Chemical', 'increased-O', '.-O']
['Urine-O', 'volume-O', 'was-O', 'increased-O', ',-O', 'while-O', 'urine-O', 'osmolality-O', 'and-O', 'free-O', 'water-O', 'reabsorption-O', 'were-O', 'decreased-O', '.-O']
['Immunoblotting-O', 'and-O', 'immunohistochemistry-O', 'revealed-O', 'decreased-O', 'expression-O', 'of-O', 'Na-B-Chemical', ',-O', 'K-B-Chemical', ',-O', 'ATPase-O', ',-O', 'NHE3-O', ',-O', 'NBC1-O', ',-O', 'and-O', 'AQP1-O', 'in-O', 'the-O', 'kidney-O', 'of-O', 'gentamicin-B-Chemical', ',-O', 'treated-O', 'rats-O', '.-O']
['The-O', 'expression-O', 'of-O', 'OAT1-O', 'and-O', 'OAT3-O', 'was-O', 'also-O', 'decreased-O', '.-O']
['Gentamicin-B-Chemical', ',-O', 'induced-O', 'nephropathy-B-Disease', 'may-O', 'at-O', 'least-O', 'in-O', 'part-O', 'be-O', 'causally-O', 'related-O', 'with-O', 'a-O', 'decreased-O', 'expression-O', 'of-O', 'Na-B-Chemical', ',-O', 'K-B-Chemical']
['Longitudinal-O', 'association-O', 'of-O', 'alcohol-B-Chemical', 'use-O', 'with-O', 'HIV-B-Disease', 'disease-I-Disease', 'progression-O', 'and-O', 'psychological-O', 'health-O', 'of-O', 'women-O', 'with-O', 'HIV-B-Disease', '.-O']
['We-O', 'evaluated-O', 'the-O', 'association-O', 'of-O', 'alcohol-B-Chemical', 'consumption-O', 'and-O', 'depression-B-Disease', ',-O', 'and-O', 'their-O', 'effects-O', 'on-O', 'HIV-B-Disease', 'disease-I-Disease', 'progression-O', 'among-O', 'women-O', 'with-O', 'HIV-B-Disease', '.-O']
['The-O', 'study-O', 'included-O', '871-O', 'women-O', 'with-O', 'HIV-B-Disease', 'who-O', 'were-O', 'recruited-O', 'from-O', '1993-O', ',-O', '1995-O', 'in-O', 'four-O', 'US-O', 'cities-O', '.-O']
['The-O', 'participants-O', 'had-O', 'physical-O', 'examination-O', ',-O', 'medical-O', 'record-O', 'extraction-O', ',-O', 'and-O', 'venipuncture-O', ',-O', 'CD4-O', '+-O', 'T-O', ',', 'cell-O', 'counts-O', 'determination-O', ',-O', 'measurement-O', 'of-O', 'depression-B-Disease', 'symptoms-O', '(-O', 'using-O', 'the-O', 'self-O', ',', 'report-O', 'Center-O', 'for-O', 'Epidemiological-O', 'Studies-O', ',', 'Depression-O', 'Scale-O', ')-O', ',', 'and-O', 'alcohol-O', 'use-O', 'assessment-O', 'at-O', 'enrollment-O', ',-O', 'and-O', 'semiannually-O', 'until-O', 'March-O', '2000-O', '.-O']
['Multilevel-O', 'random-O', 'coefficient-O', 'ordinal-O', 'models-O', 'as-O', 'well-O', 'as-O', 'multilevel-O', 'models-O', 'with-O', 'joint-O', 'responses-O', 'were-O', 'used-O', 'in-O', 'the-O', 'analysis-O', '.-O']
['There-O', 'was-O', 'no-O', 'significant-O', 'association-O', 'between-O', 'level-O', 'of-O', 'alcohol-B-Chemical', 'use-O', 'and-O', 'CD4-O', '+-O', 'T-O', ',', 'cell-O', 'counts-O', '.-O']
['When-O', 'participants-O', 'were-O', 'stratified-O', 'by-O', 'antiretroviral-O', 'therapy-O', '(', 'ART-O', ')', 'use-O', ',-O', 'the-O', 'association-O', 'between-O', 'alcohol-B-Chemical', 'and-O', 'CD4-O', '+-O', 'T-O', ',', 'cell-O', 'did-O', 'not-O', 'reach-O', 'statistical-O', 'significance-O', '.-O']
['The-O', 'association-O', 'between-O', 'alcohol-B-Chemical', 'consumption-O', 'and-O', 'depression-B-Disease', 'was-O', 'significant-O', '(-O', 'p-O', '<-O', '0-O', '.-O']
['001-O', ').-O', 'Depression-B-Disease', 'had-O', 'a-O', 'significant-O', 'negative-O', 'effect-O', 'on-O', 'CD4-O', '+-O', 'T-O', 'cell-O', 'counts-O', 'over-O', 'time-O', 'regardless-O', 'of-O', 'ART-O', 'use-O', '.-O']
['Our-O', 'findings-O', 'suggest-O', 'that-O', 'alcohol-B-Chemical', 'consumption-O', 'has-O', 'a-O', 'direct-O', 'association-O', 'with-O', 'depression-B-Disease', '.-O']
['Moreover-O', ',-O', 'depression-B-Disease', 'is-O', 'associated-O', 'with-O', 'HIV-B-Disease', 'disease-I-Disease', 'progression-O', '.-O']
['Our-O', 'findings-O', 'have-O', 'implications-O', 'for-O', 'the-O', 'provision-O', 'of-O', 'alcohol-B-Chemical']
['Chemokine-O', 'CCL2-B-Chemical', 'and-O', 'its-O', 'receptor-O', 'CCR2-B-Chemical', 'are-O', 'increased-O', 'in-O', 'the-O', 'hippocampus-O', 'following-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'status-B-Disease', 'epilepticus-I-Disease', '.-O']
['BACKGROUND-O', ':-O', 'Neuroinflammation-B-Disease', 'occurs-O', 'after-O', 'seizures-B-Disease', 'and-O', 'is-O', 'implicated-O', 'in-O', 'epileptogenesis-B-Disease', '.-O']
['CCR2-O', 'is-O', 'a-O', 'chemokine-O', 'receptor-O', 'for-O', 'CCL2-B-Chemical', 'and-O', 'their-O', 'interaction-O', 'mediates-O', 'monocyte-O', 'infiltration-O', 'in-O', 'the-O', 'neuroinflammatory-O', 'cascade-O', 'triggered-O', 'in-O', 'different-O', 'brain-O', 'pathologies-O', '.-O']
['In-O', 'this-O', 'work-O', 'CCR2-O', 'and-O', 'CCL2-O', 'expression-O', 'were-O', 'examined-O', 'following-O', 'status-B-Disease', 'epilepticus-I-Disease', '(-O', 'SE-B-Disease', ')-O', 'induced-O', 'by-O', 'pilocarpine-B-Chemical', 'injection-O', '.-O']
['METHODS-O', ':-O', 'SE-B-Disease', 'was-O', 'induced-O', 'by-O', 'pilocarpine-B-Chemical', 'injection-O', '.-O']
['Control-O', 'rats-O', 'were-O', 'injected-O', 'with-O', 'saline-O', 'instead-O', 'of-O', 'pilocarpine-B-Chemical', '.-O']
['Five-O', 'days-O', 'after-O', 'SE-B-Disease', ',-O', 'CCR2-O', 'staining-O', 'in-O', 'neurons-O', 'and-O', 'glial-O', 'cells-O', 'was-O', 'examined-O', 'using-O', 'imunohistochemical-O', 'analyses-O', '.-O']
['The-O', 'number-O', 'of-O', 'CCR2-O', 'positive-O', 'cells-O', 'was-O', 'determined-O', 'using-O', 'stereology-O', 'probes-O', 'in-O', 'the-O', 'hippocampus-O', '.-O']
['CCL2-O', 'expression-O', 'in-O', 'the-O', 'hippocampus-O', 'was-O', 'examined-O', 'by-O', 'molecular-O', 'assay-O', '.-O']
['RESULTS-O', ':-O', 'Increased-O', 'CCR2-O', 'was-O', 'observed-O', 'in-O', 'the-O', 'hippocampus-O', 'after-O', 'SE-B-Disease', '.-O']
['Seizures-B-Disease', 'also-O', 'resulted-O', 'in-O', 'alterations-O', 'to-O', 'the-O', 'cell-O', 'types-O', 'expressing-O', 'CCR2-B-Chemical', '.-O']
['Increased-O', 'numbers-O', 'of-O', 'neurons-O', 'that-O', 'expressed-O', 'CCR2-O', 'was-O', 'observed-O', 'following-O', 'SE-B-Disease', '.-O']
['Microglial-O', 'cells-O', 'were-O', 'more-O', 'closely-O', 'apposed-O', 'to-O', 'the-O', 'CCR2-B-Chemical', ',-O', 'labeled-O', 'cells-O', 'in-O', 'SE-B-Disease', 'rats-O', '.-O']
['In-O', 'addition-O', ',-O', 'rats-O', 'that-O', 'experienced-O', 'SE-B-Disease', 'exhibited-O', 'CCR2-O', 'labeling-O', 'in-O', 'populations-O', 'of-O', 'hypertrophied-O', 'astrocytes-O', ',-O', 'especially-O', 'in-O', 'CA1-O', 'and-O', 'dentate-O', 'gyrus-O', '.-O']
['These-O', 'CCR2-B-Chemical', '+-O', 'astroctytes-O', 'were-O', 'not-O', 'observed-O', 'in-O', 'control-O', 'rats-O', '.-O']
['Examination-O', 'of-O', 'CCL2-O', 'expression-O', 'showed-O', 'that-O', 'it-O', 'was-O', 'elevated-O', 'in-O', 'the-O', 'hippocampus-O', 'following-O', 'SE-B-Disease', '.-O']
['CONCLUSION-O', ':-O', 'The-O', 'data-O', 'show-O', 'that-O', 'CCR2-O', 'and-O', 'CCL2-O', 'are-O', 'up-O', 'regulated-O', 'in-O', 'the-O', 'hippocampus-O', 'after-O', 'pilocarpine-B-Chemical', ',-O', 'induced-O', 'SE-B-Disease', '.-O']
['Seizures-B-Disease', 'also-O', 'result-O', 'in-O', 'changes-O', 'to-O', 'CCR2-O', 'receptor-O', 'expression-O', 'in-O', 'neurons-O', 'and-O', 'astrocytes-O', '.-O']
['These-O', 'changes-O', 'might-O', 'be-O', 'involved-O', 'in-O', 'detrimental-O', 'neuroplasticity-O', 'and-O', 'neuroinflammatory-O', 'changes-O', 'that-O', 'occur-O', 'following-O', 'seizures-B-Disease']
['Metallothionein-B-Chemical', 'induction-O', 'reduces-O', 'caspase-O', ',-O', '3-O', 'activity-O', 'and-O', 'TNFalpha-B-Chemical', 'levels-O', 'with-O', 'preservation-O', 'of-O', 'cognitive-O', 'function-O', 'and-O', 'intact-O', 'hippocampal-O', 'neurons-O', 'in-O', 'carmustine-B-Chemical', ',-O', 'treated-O', 'rats-O', '.-O']
['Hippocampal-O', 'integrity-O', 'is-O', 'essential-O', 'for-O', 'cognitive-O', 'functions-O', '.-O']
['On-O', 'the-O', 'other-O', 'hand-O', ',-O', 'induction-O', 'of-O', 'metallothionein-B-Chemical', '(-O', 'MT-O', ')-O', 'by-O', 'ZnSO(4)-B-Chemical', 'and-O', 'its-O', 'role-O', 'in-O', 'neuroprotection-O', 'has-O', 'been-O', 'documented-O', '.-O']
['The-O', 'present-O', 'study-O', 'aimed-O', 'to-O', 'explore-O', 'the-O', 'effect-O', 'of-O', 'MT-O', 'induction-O', 'on-O', 'carmustine-B-Chemical', '(-O', 'BCNU-B-Chemical', ')-O', 'induced-O', 'hippocampal-O', 'cognitive-O', 'dysfunction-O', 'in-O', 'rats-O', '.-O']
['A-O', 'total-O', 'of-O', '60-O', 'male-O', 'Wistar-O', 'albino-O', 'rats-O', 'were-O', 'randomly-O', 'divided-O', 'into-O', 'four-O', 'groups-O', '(-O', '15-O', '/-O', 'group-O', '):-O', 'The-O', 'control-O', 'group-O', 'injected-O', 'with-O', 'single-O', 'doses-O', 'of-O', 'normal-O', 'saline-O', '(-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ')-O', 'followed-O', '24-O', 'h-O', 'later-O', 'by-O', 'BCNU-B-Chemical', 'solvent-O', '(-O', 'i-O', '.-O']
['v-O', ')-O', '.-O', 'The-O', 'second-O', 'group-O', 'administered-O', 'ZnSO(4)-B-Chemical', '(-O', '0-O', '.-O']
['1-O', 'micromol-O', '/-O', '10-O', 'microl-O', 'normal-O', 'saline-O', ',-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ',-O', 'once-O', ')-O', 'then-O', 'BCNU-B-Chemical', 'solvent-O', '(-O', 'i-O', '.-O']
['v-O', ')-O', 'after-O', '24-O', 'h-O', '.-O']
['Third-O', 'group-O', 'received-O', 'BCNU-B-Chemical', '(-O', '20-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['v-O', ',-O', 'once-O', ')-O', '24-O', 'h-O', 'after-O', 'injection-O', 'with-O', 'normal-O', 'saline-O', '(-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ').-O', 'Fourth-O', 'group-O', 'received-O', 'a-O', 'single-O', 'dose-O', 'of-O', 'ZnSO(4)-B-Chemical', '(-O', '0-O', '.-O']
['1-O', 'micromol-O', '/-O', '10-O', 'microl-O', 'normal-O', 'saline-O', ',-O', 'i-O', '.-O']
['c-O', '.-O']
['v-O', ')-O', 'then-O', 'BCNU-B-Chemical', '(-O', '20-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['v-O', ',-O', 'once-O', ')-O', 'after-O', '24-O', 'h-O', '.-O']
['The-O', 'obtained-O', 'data-O', 'revealed-O', 'that-O', 'BCNU-B-Chemical', 'administration-O', 'resulted-O', 'in-O', 'deterioration-O', 'of-O', 'learning-O', 'and-O', 'short-term-O', 'memory-O', '(-O', 'STM-O', '),O', 'as-O', 'measured-O', 'by-O', 'using-O', 'radial-O', 'arm-O', 'water-O', 'maze-O', ',-O', 'accompanied-O', 'with-O', 'decreased-O', 'hippocampal-O', 'glutathione-B-Chemical', 'reductase-O', '(-O', 'GR-O', ')-O', 'activity-O', 'and-O', 'reduced-O', 'glutathione-B-Chemical', '(-O', 'GSH-B-Chemical', ')-O', 'content-O', '.-O']
['Also-O', ',-O', 'BCNU-B-Chemical', 'administration-O', 'increased-O', 'serum-O', 'tumor-O', 'necrosis-O', 'factor-O', ',-O', 'alpha-O', '(-O', 'TNFalpha-O', ')-O', 'hippocampal-O', 'MT-O', 'and-O', 'malondialdehyde-O', '(-O', 'MDA-O', ')-O', 'contents-O', 'as-O', 'well-O', 'as-O', 'caspase-O', ',-O', '3-O', 'activity-O', 'in-O', 'addition-O', 'to-O', 'histological-O', 'alterations-O', '.-O']
['ZnSO(4)-B-Chemical', 'pretreatment-O', 'counteracted-O', 'BCNU-B-Chemical', ',-O', 'induced-O', 'inhibition-O', 'of-O', 'GR-B-Chemical', 'and-O', 'depletion-O', 'of-O', 'GSH-B-Chemical', 'and-O', 'resulted-O', 'in-O', 'significant-O', 'reduction-O', 'in-O', 'the-O', 'levels-O', 'of-O', 'MDA-B-Chemical', 'and-O', 'TNFalpha-B-Chemical', 'as-O', 'well-O', 'as-O', 'the-O', 'activity-O', 'of-O', 'caspase-O', ',-O', '3-O', '.-O']
['The-O', 'histological-O', 'features-O', 'were-O', 'improved-O', 'in-O', 'hippocampus-O', 'of-O', 'rats-O', 'treated-O', 'with-O', 'ZnSO(4)-B-Chemical', '+-O', 'BCNU-B-Chemical', 'compared-O', 'to-O', 'only-O', 'BCNU-B-Chemical', ',-O', 'treated-O', 'animals-O', '.-O']
['In-O', 'conclusion-O', ',-O', 'MT-O', 'induction-O', 'halts-O', 'BCNU-B-Chemical', ',-O', 'induced-O', 'hippocampal-O', 'toxicity-O', 'as-O', 'it-O', 'prevented-O', 'GR-B-Chemical', 'inhibition-O', 'and-O', 'GSH-B-Chemical', 'depletion-O', 'and-O', 'counteracted-O', 'the-O', 'increased-O', 'levels-O', 'of-O', 'TNFalpha-B-Chemical', ',-O', 'MDA-B-Chemical']
['Fatal-O', 'carbamazepine-B-Chemical', 'induced-O', 'fulminant-O', 'eosinophilic-O', '(-O', 'hypersensitivity-B-Disease', ')', 'myocarditis-B-Disease', ':-O', 'emphasis-O', 'on-O', 'anatomical-O', 'and-O', 'histological-O', 'characteristics-O', ',-O', 'mechanisms-O', 'and-O', 'genetics-O', 'of-O', 'drug-O', 'hypersensitivity-B-Disease', 'and-O', 'differential-O', 'diagnosis-O', '.-O']
['The-O', 'most-O', 'severe-O', 'adverse-O', 'reactions-O', 'to-O', 'carbamazepine-B-Chemical', 'have-O', 'been-O', 'observed-O', 'in-O', 'the-O', 'haemopoietic-O', 'system-O', ',-O', 'the-O', 'liver-O', 'and-O', 'the-O', 'cardiovascular-O', 'system-O', '.-O']
['A-O', 'frequently-O', 'fatal-O', ',-O', 'although-O', 'exceptionally-O', 'rare-O', 'side-O', 'effect-O', 'of-O', 'carbamazepine-B-Chemical', 'is-O', 'necrotizing-O', 'eosinophilic-O', '(-O', 'hypersensitivity-B-Disease', ')-O', 'myocarditis-B-Disease', '.-O']
['We-O', 'report-O', 'a-O', 'case-O', 'of-O', 'hypersensitivity-B-Disease', 'myocarditis-I-Disease', 'secondary-O', 'to-O', 'administration-O', 'of-O', 'carbamazepine-B-Chemical', '.-O']
['Acute-O', 'hypersensitivity-B-Disease', 'myocarditis-B-Disease', 'was-O', 'not-O', 'suspected-O', 'clinically-O', ',-O', 'and-O', 'the-O', 'diagnosis-O', 'was-O', 'made-O', 'post-O', ',-O', 'mortem-O', '.-O']
['Histology-O', 'revealed-O', 'diffuse-O', 'infiltration-O', 'of-O', 'the-O', 'myocardium-O', 'by-O', 'eosinophils-O', 'and-O', 'lymphocytes-O', 'with-O', 'myocyte-O', 'damage-B-Disease', '.-O']
['Clinically-O', ',-O', 'death-B-Disease', 'was-O', 'due-O', 'to-O', 'cardiogenic-B-Disease', 'shock-B-Disease', '.-O']
['To-O', 'best-O', 'of-O', 'our-O', 'knowledge-O', 'this-O', 'is-O', 'the-O', 'second-O', 'case-O', 'of-O', 'fatal-O', 'carbamazepine-B-Chemical', 'induced-O', 'myocarditis-B-Disease']
['Neuropsychiatric-O', 'behaviors-O', 'in-O', 'the-O', 'MPTP-B-Chemical', 'marmoset-O', 'model-O', 'of-O', 'Parkinson-B-Disease', 'disease-I-Disease', '.-O']
['OBJECTIVES-O', ':-O', 'Neuropsychiatric-O', 'symptoms-O', 'are-O', 'increasingly-O', 'recognised-O', 'as-O', 'a-O', 'significant-O', 'problem-O', 'in-O', 'patients-O', 'with-O', 'Parkinson-B-Disease', 'disease-I-Disease', '(-O', 'PD-B-Disease', ')-O', '.', 'These-O', 'symptoms-O', 'may-O', 'be-O', 'due-O', 'to-O', 'x-O', 'sensitisation-O', 'x-O', 'following-O', 'repeated-O', 'levodopa-B-Chemical', 'treatment-O', 'or-O', 'a-O', 'direct-O', 'effect-O', 'of-O', 'dopamine-B-Chemical', 'on-O', 'the-O', 'disease-O', 'state-O', '.-O']
['The-O', 'levodopa-B-Chemical', ',-O', 'treated-O', 'MPTP-B-Chemical', ',-O', 'lesioned-O', 'marmoset-O', 'was-O', 'used-O', 'as-O', 'a-O', 'model-O', 'of-O', 'neuropsychiatric-O', 'symptoms-O', 'in-O', 'PD-B-Disease', 'patients-O', '.-O']
['Here-O', 'we-O', 'compare-O', 'the-O', 'time-O', 'course-O', 'of-O', 'levodopa-B-Chemical', ',-O', 'induced-O', 'motor-O', 'fluctuations-O', 'and-O', 'neuropsychiatric-like-O', 'behaviors-O', 'to-O', 'determine-O', 'the-O', 'relationship-O', 'between-O', 'duration-O', 'of-O', 'treatment-O', 'and-O', 'onset-O', 'of-O', 'symptoms-O', '.-O']
['METHODS-O', ':-O', 'Marmosets-O', 'were-O', 'administered-O', '1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-B-Chemical', '(-O', '2-O', '.-O']
['0-O', 'mg-O', '/-O', 'kg-O', 's-O', '.-O']
['c-O', ')-O', 'for-O', 'five-O', 'days-O', ',-O', 'resulting-O', 'in-O', 'stable-O', 'parkinsonism-B-Disease', '.-O']
['Levodopa-B-Chemical', '(-O', '15-O', 'mg-O', '/-O', 'kg-O', 'and-O', 'benserazide-B-Chemical', ',-O', '3-O', '.-O']
['75-O', 'mg-O', '/-O', 'kg-O', ')-O', 'p-O', '.-O']
['o-O', '.-O']
['b-O', '.-O']
['i-O', '.-O']
['d-O', ',-O', 'was-O', 'administered-O', 'for-O', '30-O', 'days-O', '.-O']
['Animals-O', 'were-O', 'evaluated-O', 'for-O', 'parkinsonian-B-Disease', 'disability-O', ',-O', 'dyskinesia-B-Disease', 'and-O', 'on-O', ',-O', 'time-O', '(-O', 'motor-O', 'fluctuations-O', ')-O', 'and-O', 'neuropsychiatric-like-O', 'behaviors-O', 'on-O', 'Day-O', '0-O', '(-O', 'prior-O', 'to-O', 'levodopa-B-Chemical', ')-O', 'and-O', 'on-O', 'Days-O', '1-O', ',-O', '7-O', ',-O', '13-O', ',-O', '27-O', 'and-O', '30-O', 'of-O', 'treatment-O', 'using-O', 'post-O', 'hoc-O', 'DVD-O', 'analysis-O', 'by-O', 'a-O', 'trained-O', 'rater-O', ',-O', 'blind-O', 'to-O', 'the-O', 'treatment-O', 'day-O', '.-O']
['RESULTS-O', ':-O', 'The-O', 'neuropsychiatric-like-O', 'behavior-O', 'rating-O', 'scale-O', 'demonstrated-O', 'high-O', 'interrater-O', 'reliability-O', 'between-O', 'three-O', 'trained-O', 'raters-O', 'of-O', 'differing-O', 'professional-O', 'backgrounds-O', '.-O']
['As-O', 'anticipated-O', ',-O', 'animals-O', 'exhibited-O', 'a-O', 'progressive-O', 'increase-O', 'in-O', 'levodopa-B-Chemical', ',-O', 'induced-O', 'motor-O', 'fluctuations-O', ',-O', 'dyskinesia-B-Disease', 'and-O', 'wearing-O', ',-O', 'off-O', ',-O', 'that-O', 'correlated-O', 'with-O', 'the-O', 'duration-O', 'of-O', 'levodopa-B-Chemical', 'therapy-O', '.-O']
['In-O', 'contrast-O', ',-O', 'levodopa-B-Chemical', ',-O', 'induced-O', 'neuropsychiatric-like-O', 'behaviors-O', 'were-O', 'present-O', 'on-O', 'Day-O', '1-O', 'of-O', 'levodopa-B-Chemical', 'treatment-O', 'and-O', 'their-O', 'severity-O', 'did-O', 'not-O', 'correlate-O', 'with-O', 'duration-O', 'of-O', 'treatment-O', '.-O']
['CONCLUSIONS-O', ':-O', 'The-O', 'data-O', 'suggest-O', 'that-O', 'neuropsychiatric-O', 'disorders-B-Disease', 'in-O', 'PD-B-Disease', 'are-O', 'more-O', 'likely-O', 'an-O', 'interaction-O', 'between-O', 'levodopa-B-Chemical']
['Contrast-O', 'medium-B-Chemical', 'nephrotoxicity-B-Disease', 'after-O', 'renal-O', 'artery-O', 'and-O', 'coronary-O', 'angioplasty-O', '.-O']
['BACKGROUND-O', ':-O', 'Renal-O', 'dysfunction-B-Disease', 'induced-O', 'by-O', 'iodinated-O', 'contrast-B-Chemical', 'medium-O', '(-O', 'CM-O', ')-O', 'administration-O', 'can-O', 'minimize-O', 'the-O', 'benefit-O', 'of-O', 'the-O', 'interventional-O', 'procedure-O', 'in-O', 'patients-O', 'undergoing-O', 'renal-O', 'angioplasty-O', '(-O', 'PTRA-O', ').-O', 'PURPOSE-O', ':-O', 'To-O', 'compare-O', 'the-O', 'susceptibility-O', 'to-O', 'nephrotoxic-O', 'effect-O', 'of-O', 'CM-O', 'in-O', 'patients-O', 'undergoing-O', 'PTRA-O', 'with-O', 'that-O', 'of-O', 'patients-O', 'submitted-O', 'to-O', 'percutaneous-O', 'coronary-O', 'intervention-O', '(-O', 'PCI-O', ').-O', 'MATERIAL-O', 'AND-O', 'METHODS-O', ':-O', 'A-O', 'total-O', 'of-O', '33-O', 'patients-O', 'successfully-O', 'treated-O', 'with-O', 'PTRA-O', '(-O', 'PTRA-O', 'group-O', ',-O', 'mean-O', 'age-O', '70-O', '+-O', '12-O', 'years-O', ',-O', '23-O', 'female-O', ',-O', 'basal-O', 'creatinine-O', '1-O', '.-O']
['46-O', '+-O', '0-O', '.-O']
['79-O', ',-O', 'range-O', '0-O', '.-O']
['7-O', ',-O', '4-O', '.-O']
['9-O', 'mg-O', '/-O', 'dl-O', ')-O', 'were-O', 'compared-O', 'with-O', '33-O', 'patients-O', 'undergoing-O', 'successful-O', 'PCI-O', '(-O', 'PCI-O', 'group-O', ')-O', 'matched-O', 'for-O', 'basal-O', 'creatinine-B-Chemical', '(-O', '1-O', '.-O']
['44-O', '+-O', '0-O', '.-O']
['6-O', ',-O', 'range-O', '0-O', '.-O']
['7-O', ',-O', '3-O', '.-O']
['4-O', 'mg-O', '/-O', 'dl-O', ')-O', 'gender-O', ',-O', 'and-O', 'age-O', '.-O']
['In-O', 'both-O', 'groups-O', 'postprocedural-O', '(-O', '48-O', 'h-O', ')-O', 'serum-O', 'creatinine-B-Chemical', 'was-O', 'measured-O', '.-O']
['RESULTS-O', ':-O', 'Postprocedural-O', 'creatinine-B-Chemical', 'level-O', 'decreased-O', 'nonsignificantly-O', 'in-O', 'the-O', 'PTRA-O', 'group-O', '(-O', '1-O', '.-O']
['46-O', '+-O', '0-O', '.-O']
['8-O', 'vs-O', '.-O']
['1-O', '.-O']
['34-O', '+-O', '0-O', '.-O']
['5-O', 'mg-O', '/-O', 'dl-O', ',-O', 'P-O', '=O', 'NS-O', ')-O', 'and-O', 'increased-O', 'significantly-O', 'in-O', 'the-O', 'PCI-O', 'group-O', '(-O', '1-O', '.-O']
['44-O', '+-O', '0-O', '.-O']
['6-O', 'vs-O', '.-O']
['1-O', '.-O']
['57-O', '+-O', '0-O', '.-O']
['7-O', 'mg-O', '/-O', 'dl-O', ',-O', 'P-O', '<-O', '0-O', '.-O']
['02-O', ').-O', 'Changes-O', 'in-O', 'serum-O', 'creatinine-B-Chemical', 'after-O', 'intervention-O', '(-O', 'after-O', ',-O', 'before-O', ')-O', 'were-O', 'significantly-O', 'different-O', 'between-O', 'the-O', 'PTRA-O', 'and-O', 'PCI-O', 'groups-O', '(-O', '0-O', '.-O']
['12-O', '+-O', '0-O', '.-O']
['5-O', 'vs-O', '.-O']
['0-O', '.-O']
['13-O', '+-O', '0-O', '.-O']
['3-O', ',-O', 'P-O', '=-O', '0-O', '.-O']
['014-O', ').-O', 'This-O', 'difference-O', 'was-O', 'not-O', 'related-O', 'to-O', 'either-O', 'a-O', 'different-O', 'clinical-O', 'risk-O', 'profile-O', 'or-O', 'to-O', 'the-O', 'volume-O', 'of-O', 'CM-O', 'administered-O', '.-O']
['CONCLUSION-O', ':-O', 'In-O', 'this-O', 'preliminary-O', 'study-O', 'patients-O', 'submitted-O', 'to-O', 'PTRA-O', 'showed-O', 'a-O', 'lower-O', 'susceptibility-O', 'to-O', 'renal-B-Disease', 'damage-I-Disease', 'induced-O', 'by-O', 'CM-B-Chemical', 'administration-O', 'than-O', 'PCI-O', 'patients-O', '.-O']
['The-O', 'effectiveness-O', 'of-O', 'PTRA-B-Chemical', 'on-O', 'renal-O', 'function-O', 'seems-O', 'to-O', 'be-O', 'barely-O', 'influenced-O', 'by-O', 'CM-B-Chemical', 'toxicity-O']
['Medical-O', 'and-O', 'psychiatric-O', 'outcomes-O', 'for-O', 'patients-O', 'transplanted-O', 'for-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'acute-B-Disease', 'liver-I-Disease', 'failure-I-Disease', ':-O', 'a-O', 'case-O', ',-O', 'control-O', 'study-O', '.-O']
['BACKGROUND-O', ':-O', 'Acetaminophen-B-Chemical', ',-O', 'induced-O', 'hepatotoxicity-B-Disease', 'is-O', 'the-O', 'most-O', 'common-O', 'cause-O', 'of-O', 'acute-O', 'liver-O', 'failure-I-Disease', '(-O', 'ALF-B-Disease', ')-O', 'in-O', 'the-O', 'UK-O', '.-O']
['Patients-O', 'often-O', 'consume-O', 'the-O', 'drug-O', 'with-O', 'suicidal-O', 'intent-O', 'or-O', 'with-O', 'a-O', 'background-O', 'of-O', 'substance-O', 'dependence-B-Disease', '.-O']
['AIMS-O', 'AND-O', 'METHODS-O', ':-O', 'We-O', 'compared-O', 'the-O', 'severity-O', 'of-O', 'pretransplant-O', 'illness-O', ',-O', 'psychiatric-O', 'co-O', ',-O', 'morbidity-O', ',-O', 'medical-O', 'and-O', 'psychosocial-O', 'outcomes-O', 'of-O', 'all-O', 'patients-O', 'who-O', 'had-O', 'undergone-O', 'liver-O', 'transplantation-O', '(-O', 'LT-O', ')-O', 'emergently-O', 'between-O', '1999-O', ',-O', '2004-O', 'for-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', '(-O', 'n-O', '=O', '36-O', ')-O', 'with-O', 'age-O', ',-O', 'and-O', 'sex-O', ',-O', 'matched-O', 'patients-O', 'undergoing-O', 'emergent-O', 'LT-O', 'for-O', 'non-O', ',-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', '(-O', 'n-O', '=O', '35-O', ')-O', 'and-O', 'elective-O', 'LT-O', 'for-O', 'chronic-O', 'liver-O', 'disease-O', '(-O', 'CLD-O', ',-O', 'n-O', '=O', '34-O', ').-O', 'RESULTS-O', ':-O', 'Acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', 'patients-O', 'undergoing-O', 'LT-O', 'had-O', 'a-O', 'greater-O', 'severity-O', 'of-O', 'pre-O', ',-O', 'LT-O', 'illness-O', 'reflected-O', 'by-O', 'higher-O', 'Acute-O', 'Physiology-O', 'and-O', 'Chronic-O', 'Health-O', 'Evaluation-O', 'II-O', 'scores-O', 'and-O', 'requirement-O', 'for-O', 'organ-O', 'support-O', 'compared-O', 'with-O', 'the-O', 'other-O', 'two-O', 'groups-O', '.-O']
['Twenty-O', '(-O', '56-O', ')-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', 'patients-O', 'had-O', 'a-O', 'formal-O', 'psychiatric-O', 'diagnosis-O', 'before-O', 'LT-O', '(-O', 'non-O', ',-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', '=', '0-O', '/', '35-O', ',-O', 'CLD-B-Disease', '=', '2-O', '/', '34-O', ';-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', 'for-O', 'all-O', ')-O', 'and-O', 'nine-O', '(-O', '25-O', ')-O', 'had-O', 'a-O', 'previous-O', 'suicide-B-Disease', 'attempt-O', '.-O']
['During-O', 'follow-O', ',-O', 'up-O', '(-O', 'median-O', '5-O', 'years-O', ')-O', ',', 'there-O', 'were-O', 'no-O', 'significant-O', 'differences-O', 'in-O', 'rejection-O', '(-O', 'acute-O', 'and-O', 'chronic-O', ')-O', ',', 'graft-O', 'failure-O', 'or-O', 'survival-O', 'between-O', 'the-O', 'groups-O', '(-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', '1-O', 'year-O', '87-O', ',', '5-O', 'years-O', '75-O', ';-O', 'non-O', ',-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', '88-O', ',', '78-O', ';-O', 'CLD-O', '93-O', ',', '82-O', '%:-O', 'P-O', '>O', '0-O', '.-O']
['6-O', 'log-O', 'rank-O', ').-O', 'Two-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', 'patients-O', 'reattempted-O', 'suicide-O', 'post-O', ',-O', 'LT-O', '(-O', 'one-O', 'died-O', '8-O', 'years-O', 'post-O', ',-O', 'LT-O', ').-O', 'CONCLUSIONS-O', ':-O', 'Despite-O', 'a-O', 'high-O', 'prevalence-O', 'of-O', 'psychiatric-O', 'disturbance-O', ',-O', 'outcomes-O', 'for-O', 'patients-O', 'transplanted-O', 'emergently-O', 'for-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', 'were-O', 'comparable-O', 'to-O', 'those-O', 'transplanted-O', 'for-O', 'non-O', ',-O', 'acetaminophen-B-Chemical', ',-O', 'induced-O', 'ALF-B-Disease', 'and-O', 'electively-O', 'for-O', 'CLD-O']
['Studies-O', 'of-O', 'synergy-O', 'between-O', 'morphine-B-Chemical', 'and-O', 'a-O', 'novel-O', 'sodium-B-Chemical', 'channel-O', 'blocker-O', ',-O', 'CNSB002-B-Chemical', ',-O', 'in-O', 'rat-O', 'models-O', 'of-O', 'inflammatory-B-Disease', 'and-O', 'neuropathic-B-Disease', 'pain-I-Disease', '.-O']
['OBJECTIVE-O', ':-O', 'This-O', 'study-O', 'determined-O', 'the-O', 'antihyperalgesic-O', 'effect-O', 'of-O', 'CNSB002-B-Chemical', ',-O', 'a-O', 'sodium-O', 'channel-O', 'blocker-O', 'with-O', 'antioxidant-O', 'properties-O', 'given-O', 'alone-O', 'and-O', 'in-O', 'combinations-O', 'with-O', 'morphine-B-Chemical', 'in-O', 'rat-O', 'models-O', 'of-O', 'inflammatory-B-Disease', 'and-O', 'neuropathic-B-Disease', 'pain-I-Disease', '.-O']
['DESIGN-O', ':-O', 'Dose-O', 'response-O', 'curves-O', 'for-O', 'nonsedating-O', 'doses-O', 'of-O', 'morphine-B-Chemical', 'and-O', 'CNSB002-B-Chemical', 'given-O', 'intraperitoneally-O', 'alone-O', 'and-O', 'together-O', 'in-O', 'combinations-O', 'were-O', 'constructed-O', 'for-O', 'antihyperalgesic-O', 'effect-O', 'using-O', 'paw-O', 'withdrawal-O', 'from-O', 'noxious-O', 'heat-O', 'in-O', 'two-O', 'rat-O', 'pain-O', 'models-O', ':-O', 'carrageenan-O', ',-O', 'induced-O', 'paw-O', 'inflammation-O', 'and-O', 'streptozotocin-B-Chemical', '(-O', 'STZ-O', ')-O', 'induced-O', 'diabetic-B-Disease', 'neuropathy-I-Disease', '.-O']
['RESULTS-O', ':-O', 'The-O', 'maximum-O', 'nonsedating-O', 'doses-O', 'were-O', ':-O', 'morphine-B-Chemical', ',-O', '3-O', '.-O']
['2-O', 'mg-O', '/-O', 'kg-O', ';-O', 'CNSB002-B-Chemical', '10-O', '.-O']
['0-O', 'mg-O', '/-O', 'kg-O', ';-O', '5-O', '.-O']
['0-O', 'mg-O', '/-O', 'kg-O', 'CNSB002-B-Chemical', 'with-O', 'morphine-B-Chemical', '3-O', '.-O']
['2-O', 'mg-O', '/-O', 'kg-O', 'in-O', 'combination-O', '.-O']
['The-O', 'doses-O', 'calculated-O', 'to-O', 'cause-O', '50-O', '%-O', 'reversal-O', 'of-O', 'hyperalgesia-B-Disease', '(-O', 'ED50-O', ')-O', 'were-O', '7-O', '.-O']
['54-O', '(-O', '1-O', '.-O']
['81-O', ')-O', 'and-O', '4-O', '.-O']
['83-O', '(-O', '1-O', '.-O']
['54-O', ')-O', 'in-O', 'the-O', 'carrageenan-B-Chemical', 'model-O', 'and-O', '44-O', '.-O']
['18-O', '(-O', '1-O', '.-O']
['37-O', ')-O', 'and-O', '9-O', '.-O']
['14-O', '(-O', '1-O', '.-O']
['24-O', ')-O', 'in-O', 'the-O', 'STZ-O', ',-O', 'induced-O', 'neuropathy-B-Disease', 'model-O', 'for-O', 'CNSB002-B-Chemical', 'and-O', 'morphine-B-Chemical', ',-O', 'respectively-O', '(-O', 'mg-O', '/-O', 'kg-O', ';-O', 'mean-O', ',-O', 'SEM-O', ')-O', '.-O', 'These-O', 'values-O', 'were-O', 'greater-O', 'than-O', 'the-O', 'maximum-O', 'nonsedating-O', 'doses-O', '.-O']
['The-O', 'ED50-O', 'values-O', 'for-O', 'morphine-B-Chemical', 'when-O', 'given-O', 'in-O', 'combination-O', 'with-O', 'CNSB002-B-Chemical', '(-O', '5-O', 'mg-O', '/-O', 'kg-O', ')-O', 'were-O', 'less-O', 'than-O', 'the-O', 'maximum-O', 'nonsedating-O', 'dose-O', ':-O', '0-O', '.-O']
['56-O', '(-O', '1-O', '.-O']
['55-O', ')-O', 'in-O', 'the-O', 'carrageenan-B-Chemical', 'model-O', 'and-O', '1-O', '.-O']
['37-O', '(-O', '1-O', '.-O']
['23-O', ')-O', 'in-O', 'the-O', 'neuropathy-B-Disease', 'model-O', '(-O', 'mg-O', '/-O', 'kg-O', ';-O', 'mean-O', ',-O', 'SEM-O', ')-O', '.-O', 'The-O', 'antinociception-O', 'after-O', 'morphine-B-Chemical', '(-O', '3-O', '.-O']
['2-O', 'mg-O', '/-O', 'kg-O', ')-O', 'was-O', 'increased-O', 'by-O', 'co-O', ',-O', 'administration-O', 'with-O', 'CNSB002-B-Chemical', 'from-O', '28-O', '.-O']
['0-O', 'and-O', '31-O', '.-O']
['7-O', '%-O', 'to-O', '114-O', '.-O']
['6-O', 'and-O', '56-O', '.-O']
['9-O', '%-O', 'reversal-O', 'of-O', 'hyperalgesia-B-Disease', 'in-O', 'the-O', 'inflammatory-O', 'and-O', 'neuropathic-B-Disease', 'models-O', ',-O', 'respectively-O', '(-O', 'P-O', '<-O', '0-O', '.-O']
['01-O', ';-O', 'one-O', 'way-O', 'analysis-O', 'of-O', 'variance-O', ',-O', 'significantly-O', 'greater-O', 'than-O', 'either-O', 'drug-O', 'given-O', 'alone-O', ')-O', 'CONCLUSIONS-O', ':-O', 'The-O', 'maximum-O', 'antihyperalgesic-O', 'effect-O', 'achievable-O', 'with-O', 'nonsedating-O', 'doses-O', 'of-O', 'morphine-B-Chemical', 'may-O', 'be-O', 'increased-O', 'significantly-O', 'when-O', 'the-O', 'drug-O', 'is-O', 'used-O', 'in-O', 'combination-O', 'with-O', 'CNSB002-B-Chemical']
['Heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', ':-O', 'a-O', 'practical-O', 'review-O', '.-O']
['Heparin-B-Chemical', ',-O', 'induced-O', 'thrombocytopenia-B-Disease', '(', 'HIT-B-Disease', ')-O', 'remains-O', 'under-O', ',-O', 'recognized-O', 'despite-O', 'its-O', 'potentially-O', 'devastating-O', 'outcomes-O', '.-O']
['It-O', 'begins-O', 'when-O', 'heparin-B-Chemical', 'exposure-O', 'stimulates-O', 'the-O', 'formation-O', 'of-O', 'heparin-B-Chemical', ',-O', 'platelet-O', 'factor-O', '4-O', 'antibodies-O', ',-O', 'which-O', 'in-O', 'turn-O', 'triggers-O', 'the-O', 'release-O', 'of-O', 'procoagulant-O', 'platelet-O', 'particles-O', '.-O']
['Thrombosis-B-Disease', 'and-O', 'thrombocytopenia-B-Disease', 'that-O', 'follow-O', 'comprise-O', 'the-O', '2-O', 'hallmark-O', 'traits-O', 'of-O', 'HIT-B-Disease', ',-O', 'with-O', 'the-O', 'former-O', 'largely-O', 'responsible-O', 'for-O', 'significant-O', 'vascular-O', 'complications-O', '.-O']
['The-O', 'prevalence-O', 'of-O', 'HIT-B-Disease', 'varies-O', 'among-O', 'several-O', 'subgroups-O', ',-O', 'with-O', 'greater-O', 'incidence-O', 'in-O', 'surgical-O', 'as-O', 'compared-O', 'with-O', 'medical-O', 'populations-O', '.-O']
['HIT-B-Disease', 'must-O', 'be-O', 'acknowledged-O', 'for-O', 'its-O', 'intense-O', 'predilection-O', 'for-O', 'thrombosis-B-Disease', 'and-O', 'suspected-O', 'whenever-O', 'thrombosis-B-Disease', 'occurs-O', 'after-O', 'heparin-B-Chemical', 'exposure-O', '.-O']
['Early-O', 'recognition-O', 'that-O', 'incorporates-O', 'the-O', 'clinical-O', 'and-O', 'serologic-O', 'clues-O', 'is-O', 'paramount-O', 'to-O', 'timely-O', 'institution-O', 'of-O', 'treatment-O', ',-O', 'as-O', 'its-O', 'delay-O', 'may-O', 'result-O', 'in-O', 'catastrophic-O', 'outcomes-O', '.-O']
['The-O', 'treatment-O', 'of-O', 'HIT-B-Disease', 'mandates-O', 'an-O', 'immediate-O', 'cessation-O', 'of-O', 'all-O', 'heparin-B-Chemical', 'exposure-O', 'and-O', 'the-O', 'institution-O', 'of-O', 'an-O', 'antithrombotic-O', 'therapy-O', ',-O', 'most-O', 'commonly-O', 'using-O', 'a-O', 'direct-O', 'thrombin-O', 'inhibitor-O', '.-O']
['Current-O', 'x-O', 'diagnostic-O', 'x-O', 'tests-O', ',-O', 'which-O', 'primarily-O', 'include-O', 'functional-O', 'and-O', 'antigenic-O', 'assays-O', ',-O', 'have-O', 'more-O', 'of-O', 'a-O', 'confirmatory-O', 'than-O', 'diagnostic-O', 'role-O', 'in-O', 'the-O', 'management-O', 'of-O', 'HIT-B-Disease', '.-O']
['Special-O', 'attention-O', 'must-O', 'be-O', 'paid-O', 'to-O', 'cardiac-B-Disease', 'patients-O', 'who-O', 'are-O', 'often-O', 'exposed-O', 'to-O', 'heparin-B-Chemical', 'multiple-O', 'times-O', 'during-O', 'their-O', 'course-O', 'of-O', 'treatment-O', '.-O']
['Direct-O', 'thrombin-O', 'inhibitors-O', 'are-O', 'appropriate-O', ',-O', 'evidence-O', ',-O', 'based-O', 'alternatives-O', 'to-O', 'heparin-B-Chemical', 'in-O', 'patients-O', 'with-O', 'a-O', 'history-O', 'of-O', 'HIT-B-Disease', ',-O', 'who-O', 'need-O', 'to-O', 'undergo-O', 'percutaneous-O', 'coronary-O', 'intervention-O', '.-O']
['As-O', 'heparin-B-Chemical', 'remains-O', 'one-O', 'of-O', 'the-O', 'most-O', 'frequently-O', 'used-O', 'medications-O', 'today-O', 'with-O', 'potential-O', 'for-O', 'HIT-B-Disease', 'with-O', 'every-O', 'heparin-B-Chemical', 'exposure-O', ',-O', 'a-O', 'close-O', 'vigilance-O', 'of-O', 'platelet-O', 'counts-O', 'must-O', 'be-O', 'practiced-O', 'whenever-O', 'heparin-B-Chemical']
['Abductor-O', 'paralysis-B-Disease', 'after-O', 'botox-B-Chemical', 'injection-O', 'for-O', 'adductor-O', 'spasmodic-O', 'dysphonia-B-Disease', '.-O']
['OBJECTIVES-O', '/', 'HYPOTHESIS-O', ':', 'Botulinum-B-Chemical', 'toxin-O', '(', 'Botox-B-Chemical', ')', 'injections-O', 'into-O', 'the-O', 'thyroarytenoid-O', 'muscles-O', 'are-O', 'the-O', 'current-O', 'standard-O', 'of-O', 'care-O', 'for-O', 'adductor-O', 'spasmodic-O', 'dysphonia-B-Disease', '(', 'ADSD-B-Disease', ').', 'Reported-O', 'adverse-O', 'effects-O', 'include-O', 'a-O', 'period-O', 'of-O', 'breathiness-O', ',', 'throat-O', 'pain-O', ',', 'and-O', 'difficulty-O', 'with-O', 'swallowing-O', 'liquids-O', '.-O']
['Here-O', 'we-O', 'report-O', 'multiple-O', 'cases-O', 'of-O', 'bilateral-O', 'abductor-B-Disease', 'paralysis-I-Disease', 'following-O', 'Botox-B-Chemical', 'injections-O', 'for-O', 'ADSD-B-Disease', ',-O', 'a-O', 'complication-O', 'previously-O', 'unreported-O', '.-O']
['STUDY-O', 'DESIGN-O', ':-O', 'Retrospective-O', 'case-O', 'series-O', '.-O']
['METHODS-O', ':-O', 'Patients-O', 'that-O', 'received-O', 'Botox-B-Chemical', 'injections-O', 'for-O', 'spasmodic-B-Disease', 'dysphonia-B-Disease', 'between-O', 'January-O', '2000-O', 'and-O', 'October-O', '2009-O', 'were-O', 'evaluated-O', '.-O']
['Patients-O', 'with-O', 'ADSD-B-Disease', 'were-O', 'identified-O', '.-O']
['The-O', 'number-O', 'of-O', 'treatments-O', 'received-O', 'and-O', 'adverse-O', 'effects-O', 'were-O', 'noted-O', '.-O']
['For-O', 'patients-O', 'with-O', 'bilateral-O', 'abductor-O', 'paralysis-B-Disease', ',-O', 'age-O', ',-O', 'sex-O', ',-O', 'paralytic-O', 'Botox-B-Chemical', 'dose-O', ',-O', 'prior-O', 'Botox-B-Chemical', 'dose-O', ',-O', 'and-O', 'course-O', 'following-O', 'paralysis-B-Disease', 'were-O', 'noted-O', '.-O']
['RESULTS-O', ':-O', 'From-O', 'a-O', 'database-O', 'of-O', '452-O', 'patients-O', 'receiving-O', 'Botox-B-Chemical', ',-O', '352-O', 'patients-O', 'had-O', 'been-O', 'diagnosed-O', 'with-O', 'ADSD-B-Disease', '.-O']
['Of-O', 'these-O', '352-O', 'patients-O', ',-O', 'eight-O', 'patients-O', 'suffered-O', 'bilateral-O', 'abductor-O', 'paralysis-B-Disease', ',-O', 'and-O', 'two-O', 'suffered-O', 'this-O', 'complication-O', 'twice-O', '.-O']
['All-O', 'affected-O', 'patients-O', 'were-O', 'females-O', 'over-O', 'the-O', 'age-O', 'of-O', '50-O', 'years-O', '.-O']
['Most-O', 'patients-O', 'had-O', 'received-O', 'treatments-O', 'prior-O', 'to-O', 'abductor-B-Disease', 'paralysis-B-Disease', 'and-O', 'continued-O', 'receiving-O', 'after-O', 'paralysis-B-Disease', '.-O']
['Seven-O', 'patients-O', 'recovered-O', 'after-O', 'a-O', 'brief-O', 'period-O', 'of-O', 'activity-O', 'restrictions-O', ',-O', 'and-O', 'one-O', 'underwent-O', 'a-O', 'tracheotomy-O', '.-O']
['The-O', 'incidence-O', 'of-O', 'abductor-B-Disease', 'paralysis-B-Disease', 'after-O', 'Botox-B-Chemical', 'injection-O', 'for-O', 'ADSD-B-Disease', 'was-O', '0-O', '.-O']
['34-O', '.-O', 'CONCLUSIONS-O', ':-O', 'Bilateral-O', 'abductor-O', 'paralysis-B-Disease', 'is-O', 'a-O', 'rare-O', 'complication-O', 'of-O', 'Botox-B-Chemical', 'injections-O', 'for-O', 'ADSD-O', ',-O', 'causing-O', 'difficulty-O', 'with-O', 'breathing-O', 'upon-O', 'exertion-O', '.-O']
['The-O', 'likely-O', 'mechanism-O', 'of-O', 'paralysis-B-Disease', 'is-O', 'diffusion-O', 'of-O', 'Botox-B-Chemical', 'around-O', 'the-O', 'muscular-O', 'process-O', 'of-O', 'the-O', 'arytenoid-O', 'to-O', 'the-O', 'posterior-O', 'cricoarytenoid-O', 'muscles-O', '.-O']
['The-O', 'paralysis-B-Disease']
['Mitochondrial-O', 'impairment-B-Disease', 'contributes-O', 'to-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'cardiac-B-Disease', 'dysfunction-I-Disease', ':-O', 'Prevention-O', 'by-O', 'the-O', 'targeted-O', 'antioxidant-O', 'MitoQ-B-Chemical', '.-O']
['The-O', 'goal-O', 'of-O', 'this-O', 'study-O', 'was-O', 'to-O', 'assess-O', 'mitochondrial-O', 'function-O', 'and-O', 'ROS-O', 'production-O', 'in-O', 'an-O', 'experimental-O', 'model-O', 'of-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'cardiac-O', 'dysfunction-O', '.-O']
['We-O', 'hypothesized-O', 'that-O', 'cocaine-B-Chemical', 'abuse-I-Disease', 'may-O', 'lead-O', 'to-O', 'altered-O', 'mitochondrial-O', 'function-O', 'that-O', 'in-O', 'turn-O', 'may-O', 'cause-O', 'left-O', 'ventricular-O', 'dysfunction-I-Disease', '.-O']
['Seven-O', 'days-O', 'of-O', 'cocaine-B-Chemical', 'administration-O', 'to-O', 'rats-O', 'led-O', 'to-O', 'an-O', 'increased-O', 'oxygen-B-Chemical', 'consumption-O', 'detected-O', 'in-O', 'cardiac-O', 'fibers-O', ',-O', 'specifically-O', 'through-O', 'complex-O', 'I-O', 'and-O', 'complex-O', 'III-O', '.-O']
['ROS-O', 'levels-O', 'were-O', 'increased-O', ',-O', 'specifically-O', 'in-O', 'interfibrillar-O', 'mitochondria-O', '.-O']
['In-O', 'parallel-O', 'there-O', 'was-O', 'a-O', 'decrease-O', 'in-O', 'ATP-B-Chemical', 'synthesis-O', ',-O', 'whereas-O', 'no-O', 'difference-O', 'was-O', 'observed-O', 'in-O', 'subsarcolemmal-O', 'mitochondria-O', '.-O']
['This-O', 'uncoupling-O', 'effect-O', 'on-O', 'oxidative-O', 'phosphorylation-O', 'was-O', 'not-O', 'detectable-O', 'after-O', 'short-O', ',-O', 'term-O', 'exposure-O', 'to-O', 'cocaine-B-Chemical', ',-O', 'suggesting-O', 'that-O', 'these-O', 'mitochondrial-O', 'abnormalities-O', 'were-O', 'a-O', 'late-O', 'rather-O', 'than-O', 'a-O', 'primary-O', 'event-O', 'in-O', 'the-O', 'pathological-O', 'response-O', 'to-O', 'cocaine-B-Chemical', '.-O']
['MitoQ-B-Chemical', ',-O', 'a-O', 'mitochondrial-O', ',-O', 'targeted-O', 'antioxidant-O', ',-O', 'was-O', 'shown-O', 'to-O', 'completely-O', 'prevent-O', 'these-O', 'mitochondrial-O', 'abnormalities-O', 'as-O', 'well-O', 'as-O', 'cardiac-B-Disease', 'dysfunction-I-Disease', 'characterized-O', 'here-O', 'by-O', 'a-O', 'diastolic-O', 'dysfunction-I-Disease', 'studied-O', 'with-O', 'a-O', 'conductance-O', 'catheter-O', 'to-O', 'obtain-O', 'pressure-O', ',-O', 'volume-O', 'data-O', '.-O']
['Taken-O', 'together-O', ',-O', 'these-O', 'results-O', 'extend-O', 'previous-O', 'studies-O', 'and-O', 'demonstrate-O', 'that-O', 'cocaine-B-Chemical', ',-O', 'induced-O', 'cardiac-B-Disease', 'dysfunction-I-Disease', 'may-O', 'be-O', 'due-O', 'to-O', 'a-O', 'mitochondrial-O', 'defect-O']
['Trimethoprim-B-Chemical', ',-O', 'induced-O', 'immune-O', 'hemolytic-B-Disease', 'anemia-I-Disease', 'in-O', 'a-O', 'pediatric-O', 'oncology-O', 'patient-O', 'presenting-O', 'as-O', 'an-O', 'acute-O', 'hemolytic-B-Disease', 'transfusion-O', 'reaction-O', '.-O']
['A-O', '10-O', ',-O', 'year-O', ',-O', 'old-O', 'male-O', 'with-O', 'acute-B-Disease', 'leukemia-I-Disease', 'presented-O', 'with-O', 'post-O', ',-O', 'chemotherapy-O', 'anemia-B-Disease', '.-O']
['During-O', 'red-O', 'cell-O', 'transfusion-O', ',-O', 'he-O', 'developed-O', 'hemoglobinuria-B-Disease', '.-O']
['Transfusion-O', 'reaction-O', 'workup-O', 'was-O', 'negative-O', '.-O']
['Drug-O', ',-O', 'induced-O', 'immune-O', 'hemolytic-B-Disease', 'anemia-I-Disease', 'was-O', 'suspected-O', 'because-O', 'of-O', 'positive-O', 'direct-O', 'antiglobulin-O', 'test-O', ',-O', 'negative-O', 'eluate-O', ',-O', 'and-O', 'microspherocytes-O', 'on-O', 'smear-O', 'pre-O', ',-O', 'and-O', 'post-O', ',-O', 'transfusion-O', '.-O']
['Drug-O', 'studies-O', 'using-O', 'the-O', 'indirect-O', 'antiglobulin-O', 'test-O', 'were-O', 'strongly-O', 'positive-O', 'with-O', 'trimethoprim-B-Chemical', 'and-O', 'trimethoprim-sulfamethoxazole-B-Chemical', 'but-O', 'negative-O', 'with-O', 'sulfamethoxazole-B-Chemical', '.-O']
['The-O', 'patient-O', 'recovered-O', 'after-O', 'discontinuing-O', 'the-O', 'drug-O', ',-O', 'with-O', 'no-O', 'recurrence-O', 'in-O', '2-O', 'years-O', '.-O']
['Other-O', 'causes-O', 'of-O', 'anemia-B-Disease', 'should-O', 'be-O', 'considered-O', 'in-O', 'patients-O', 'with-O', 'worse-O', ',-O', 'than-O', ',-O', 'expected-O', 'anemia-B-Disease', 'after-O', 'chemotherapy-O', '.-O']
['Furthermore-O', ',-O', 'hemolysis-B-Disease']
['Blockade-O', 'of-O', 'endothelial-O', ',-O', 'mesenchymal-O', 'transition-O', 'by-O', 'a-O', 'Smad3-O', 'inhibitor-O', 'delays-O', 'the-O', 'early-O', 'development-O', 'of-O', 'streptozotocin-B-Chemical', ',-O', 'induced-O', 'diabetic-B-Disease', 'nephropathy-I-Disease', '.-O']
['OBJECTIVE-O', ':', 'A-O', 'multicenter-O', ',-O', 'controlled-O', 'trial-O', 'showed-O', 'that-O', 'early-O', 'blockade-O', 'of-O', 'the-O', 'renin-O', ',-O', 'angiotensin-B-Chemical', 'system-O', 'in-O', 'patients-O', 'with-O', 'type-O', '1-O', 'diabetes-B-Disease', 'and-O', 'normoalbuminuria-O', 'did-O', 'not-O', 'retard-O', 'the-O', 'progression-O', 'of-O', 'nephropathy-B-Disease', ',-O', 'suggesting-O', 'that-O', 'other-O', 'mechanism-O', '(-O', 's-O', ')', 'are-O', 'involved-O', 'in-O', 'the-O', 'pathogenesis-O', 'of-O', 'early-O', 'diabetic-B-Disease', 'nephropathy-B-Disease', '(-O', 'diabetic-B-Disease', 'nephropathy-B-Disease', ').-O', 'We-O', 'have-O', 'previously-O', 'demonstrated-O', 'that-O', 'endothelial-O', ',-O', 'mesenchymal-O', ',-O', 'transition-O', '(-O', 'EndoMT-O', ')', 'contributes-O', 'to-O', 'the-O', 'early-O', 'development-O', 'of-O', 'renal-O', 'interstitial-O', 'fibrosis-O', 'independently-O', 'of-O', 'microalbuminuria-O', 'in-O', 'mice-O', 'with-O', 'streptozotocin-B-Chemical', '(-O', 'STZ-B-Chemical', ')-', 'induced-O', 'diabetes-B-Disease', '.-O']
['In-O', 'the-O', 'present-O', 'study-O', ',-O', 'we-O', 'hypothesized-O', 'that-O', 'blocking-O', 'EndoMT-O', 'reduces-O', 'the-O', 'early-O', 'development-O', 'of-O', 'diabetic-B-Disease', 'nephropathy-I-Disease', '.-O']
['RESEARCH-O', 'DESIGN-O', 'AND-O', 'METHODS-O', ':-O', 'EndoMT-O', 'was-O', 'induced-O', 'in-O', 'a-O', 'mouse-O', 'pancreatic-O', 'microvascular-O', 'endothelial-O', 'cell-O', 'line-O', '(-O', 'MMEC-O', ')', 'in-O', 'the-O', 'presence-O', 'of-O', 'advanced-O', 'glycation-O', 'end-O', 'products-O', '(-O', 'AGEs-O', ')', 'and-O', 'in-O', 'the-O', 'endothelial-O', 'lineage-O', ',-O', 'traceble-O', 'mouse-O', 'line-O', 'Tie2-O', ',-O', 'Cre-O', ';-O', 'Loxp-O', ',-O', 'EGFP-O', 'by-O', 'administration-O', 'of-O', 'AGEs-O', ',-O', 'with-O', 'nonglycated-O', 'mouse-O', 'albumin-O', 'serving-O', 'as-O', 'a-O', 'control-O', '.-O']
['Phosphorylated-O', 'Smad3-O', 'was-O', 'detected-O', 'by-O', 'immunoprecipitation-O', '/-O', 'Western-O', 'blotting-O', 'and-O', 'confocal-O', 'microscopy-O', '.-O']
['Blocking-O', 'studies-O', 'using-O', 'receptor-O', 'for-O', 'AGE-B-Chemical', 'siRNA-O', 'and-O', 'a-O', 'specific-O', 'inhibitor-O', 'of-O', 'Smad3-O', '(-O', 'SIS3-B-Chemical', ')-O', 'were-O', 'performed-O', 'in-O', 'MMECs-O', 'and-O', 'in-O', 'STZ-B-Chemical', '-O', 'induced-O', 'diabetic-B-Disease', 'nephropathy-I-Disease', 'in-O', 'Tie2-O', '-O', 'Cre-O', ';-O', 'Loxp-O', '-O', 'EGFP-O', 'mice-O', '.-O']
['RESULTS-O', ':-O', 'Confocal-O', 'microscopy-O', 'and-O', 'real-O', ',', 'time-O', 'PCR-O', 'demonstrated-O', 'that-O', 'AGEs-B-Chemical', 'induced-O', 'EndoMT-O', 'in-O', 'MMECs-O', 'and-O', 'in-O', 'Tie2-O', ',-O', 'Cre-O', ';-O', 'Loxp-O', ',-O', 'EGFP-O', 'mice-O', '.-O']
['Immunoprecipitation-O', '/', 'Western-O', 'blotting-O', 'showed-O', 'that-O', 'Smad3-O', 'was-O', 'activated-O', 'by-O', 'AGEs-B-Chemical', 'but-O', 'was-O', 'inhibited-O', 'by-O', 'SIS3-B-Chemical', 'in-O', 'MMECs-O', 'and-O', 'in-O', 'STZ-B-Chemical', ',-O', 'induced-O', 'diabetic-B-Disease', 'nephropathy-I-Disease', '.-O']
['Confocal-O', 'microscopy-O', 'and-O', 'real-O', ',', 'time-O', 'PCR-O', 'further-O', 'demonstrated-O', 'that-O', 'SIS3-B-Chemical', 'abrogated-O', 'EndoMT-O', ',-O', 'reduced-O', 'renal-O', 'fibrosis-B-Disease', ',-O', 'and-O', 'retarded-O', 'progression-O', 'of-O', 'nephropathy-B-Disease', '.-O']
['CONCLUSIONS-O', ':-O', 'EndoMT-O', 'is-O', 'a-O', 'novel-O', 'pathway-O', 'leading-O', 'to-O', 'early-O', 'development-O', 'of-O', 'diabetic-B-Disease', 'nephropathy-I-Disease', '.-O']
['Blockade-O', 'of-O', 'EndoMT-O', 'by-O', 'SIS3-B-Chemical', 'may-O', 'provide-O', 'a-O', 'new-O', 'strategy-O', 'to-O', 'retard-O', 'the-O', 'progression-O', 'of-O', 'diabetic-B-Disease', 'nephropathy-I-Disease', 'and-O', 'other-O', 'diabetes-B-Disease', 'complications-O']
['Cytostatic-O', 'and-O', 'anti-O', ',-O', 'angiogenic-O', 'effects-O', 'of-O', 'temsirolimus-B-Chemical', 'in-O', 'refractory-O', 'mantle-O', 'cell-O', 'lymphoma-B-Disease', '.-O']
['Mantle-O', 'cell-O', 'lymphoma-B-Disease', '(-O', 'MCL-O', ')-O', 'is-O', 'a-O', 'rare-O', 'and-O', 'aggressive-O', 'type-O', 'of-O', 'B-cell-O', 'non-Hodgkin-B-Disease', 'lymphoma-I-Disease', '.-O']
['Patients-O', 'become-O', 'progressively-O', 'refractory-O', 'to-O', 'conventional-O', 'chemotherapy-O', ',-O', 'and-O', 'their-O', 'prognosis-O', 'is-O', 'poor-O', '.-O']
['However-O', ',-O', 'a-O', '38-O', '%-O', 'remission-O', 'rate-O', 'has-O', 'been-O', 'recently-O', 'reported-O', 'in-O', 'refractory-O', 'MCL-O', 'treated-O', 'with-O', 'temsirolimus-B-Chemical', ',-O', 'a-O', 'mTOR-O', 'inhibitor-O', '.-O']
['Here-O', 'we-O', 'had-O', 'the-O', 'opportunity-O', 'to-O', 'study-O', 'a-O', 'case-O', 'of-O', 'refractory-O', 'MCL-B-Disease', 'who-O', 'had-O', 'tumor-B-Disease', 'regression-O', 'two-O', 'months-O', 'after-O', 'temsirolimus-B-Chemical', 'treatment-O', ',-O', 'and-O', 'a-O', 'progression-O', ',-O', 'free-O', 'survival-O', 'of-O', '10-O', 'months-O', '.-O']
['In-O', 'this-O', 'case-O', ',-O', 'lymph-O', 'node-O', 'biopsies-O', 'were-O', 'performed-O', 'before-O', 'and-O', 'six-O', 'months-O', 'after-O', 'temsirolimus-B-Chemical', 'therapy-O', '.-O']
['Comparison-O', 'of-O', 'the-O', 'two-O', 'biopsies-O', 'showed-O', 'that-O', 'temsirolimus-B-Chemical', 'inhibited-O', 'tumor-B-Disease', 'cell-O', 'proliferation-O', 'through-O', 'cell-O', 'cycle-O', 'arrest-O', ',-O', 'but-O', 'did-O', 'not-O', 'induce-O', 'any-O', 'change-O', 'in-O', 'the-O', 'number-O', 'of-O', 'apoptotic-O', 'tumor-B-Disease', 'cells-O', '.-O']
['Apart-O', 'from-O', 'this-O', 'cytostatic-O', 'effect-O', ',-O', 'temsirolimus-B-Chemical', 'had-O', 'an-O', 'antiangiogenic-O', 'effect-O', 'with-O', 'decrease-O', 'of-O', 'tumor-B-Disease', 'microvessel-O', 'density-O', 'and-O', 'of-O', 'VEGF-B-Chemical', 'expression-O', '.-O']
['Moreover-O', ',-O', 'numerous-O', 'patchy-O', ',-O', 'well-O', ',-O', 'limited-O', 'fibrotic-O', 'areas-O', ',-O', 'compatible-O', 'with-O', 'post-O', ',-O', 'necrotic-O', 'tissue-O', 'repair-O', ',-O', 'were-O', 'found-O', 'after-O', '6-O', ',-O', 'month-O', 'temsirolimus-B-Chemical', 'therapy-O', '.-O']
['Thus-O', ',-O', 'temsirolimus-B-Chemical', 'reduced-O', 'tumor-B-Disease', 'burden-O', 'through-O', 'associated-O', 'cytostatic-O', 'and-O', 'anti-O', ',-O', 'angiogenic-O', 'effects-O', '.-O']
['This-O', 'dual-O', 'effect-O', 'of-O', 'temsirolimus-B-Chemical', 'on-O', 'tumor-B-Disease', 'tissue-O', 'could-O', 'contribute-O', 'to-O', 'its-O', 'recently-O', 'reported-O', 'efficiency-O', 'in-O', 'refractory-O', 'MCL-B-Disease']
['Syncope-B-Disease', 'caused-O', 'by-O', 'hyperkalemia-B-Disease', 'during-O', 'use-O', 'of-O', 'a-O', 'combined-O', 'therapy-O', 'with-O', 'the-O', 'angiotensin-B-Chemical', ',-O', 'converting-O', 'enzyme-O', 'inhibitor-O', 'and-O', 'spironolactone-B-Chemical', '.-O']
['A-O', '76-O', 'year-O', ',-O', 'old-O', 'woman-O', 'with-O', 'a-O', 'history-O', 'of-O', 'coronary-B-Disease', 'artery-O', 'bypass-O', 'grafting-O', 'and-O', 'prior-O', 'myocardial-B-Disease', 'infarction-I-Disease', 'was-O', 'transferred-O', 'to-O', 'the-O', 'emergency-O', 'room-O', 'with-O', 'loss-O', 'of-O', 'consciousness-O', 'due-O', 'to-O', 'marked-O', 'bradycardia-O', 'caused-O', 'by-O', 'hyperkalemia-O', '.-O']
['The-O', 'concentration-O', 'of-O', 'serum-O', 'potassium-B-Chemical', 'was-O', 'high-O', ',-O', 'and-O', 'normal-O', 'sinus-B-Disease', 'rhythm-O', 'was-O', 'restored-O', 'after-O', 'correction-O', 'of-O', 'the-O', 'serum-O', 'potassium-B-Chemical', 'level-O', '.-O']
['The-O', 'cause-O', 'of-O', 'hyperkalemia-B-Disease', 'was-O', 'considered-O', 'to-O', 'be-O', 'several-O', 'doses-O', 'of-O', 'spiranolactone-B-Chemical', ',-O', 'an-O', 'aldosterone-B-Chemical', 'antagonist-O', ',-O', 'in-O', 'addition-O', 'to-O', 'the-O', 'long-O', '--O', 'term-O', 'intake-O', 'of-O', 'ramipril-B-Chemical', ',-O', 'an-O', 'ACE-B-Chemical', 'inhibitor-O', '.-O']
['This-O', 'case-O', 'is-O', 'a-O', 'good-O', 'example-O', 'of-O', 'electrolyte-O', 'imbalance-O', 'causing-O', 'acute-O', 'life-O', ',-O', 'threatening-O', 'cardiac-O', 'events-O', '.-O']
['Clinicians-O', 'should-O', 'be-O', 'alert-O', 'to-O', 'the-O', 'possibility-O', 'of-O', 'hyperkalemia-B-Disease', ',-O', 'especially-O', 'in-O', 'elderly-O', 'patients-O', 'using-O', 'ACE-B-Chemical', '/', 'ARB-B-Chemical', 'in-O', 'combination-O', 'with-O', 'potassium-B-Chemical', 'sparing-O', 'agents-O', 'and-O', 'who-O', 'have-O', 'mild-O', 'renal-O', 'disturbance-O']
['Diffuse-O', 'skeletal-O', 'pain-B-Disease', 'after-O', 'administration-O', 'of-O', 'alendronate-B-Chemical', '.-O']
['BACKGROUND-O', ':-O', 'Osteoporosis-B-Disease', 'is-O', 'caused-O', 'by-O', 'bone-O', 'resorption-O', 'in-O', 'excess-O', 'of-O', 'bone-O', 'formation-O', ',-O', 'and-O', 'bisphosphonates-B-Chemical', ',-O', 'are-O', 'used-O', 'to-O', 'inhibit-O', 'bone-O', 'resorption-O', '.-O']
['Alendronate-B-Chemical', ',-O', 'a-O', 'biphosphonate-O', ',-O', 'is-O', 'effective-O', 'for-O', 'both-O', 'the-O', 'treatment-O', 'and-O', 'prevention-O', 'of-O', 'osteoporosis-B-Disease', 'in-O', 'postmenopausal-O', 'women-O', '.-O']
['Side-O', 'effects-O', 'are-O', 'relatively-O', 'few-O', 'and-O', 'prominently-O', 'gastrointestinal-B-Disease', '.-O']
['Musculoskeletal-B-Disease', 'pain-I-Disease', 'may-O', 'be-O', 'an-O', 'important-O', 'side-O', 'effect-O', 'in-O', 'these-O', 'patients-O', '.-O']
['We-O', 'presented-O', 'a-O', 'patient-O', 'admitted-O', 'to-O', 'our-O', 'out-O', 'patient-O', 'clinic-O', 'with-O', 'diffuse-O', 'skeletal-O', 'pain-B-Disease', 'after-O', 'three-O', 'consecutive-O', 'administration-O', 'of-O', 'alendronate-B-Chemical', '.-O']
['CONCLUSION-O', ':-O', 'We-O', 'conclude-O', 'that-O', 'patients-O', 'with-O', 'osteoporosis-B-Disease', 'can-O', 'report-O', 'pain-B-Disease', ',-O', 'and-O', 'bisphosphonate-B-Chemical', ',-O', 'related-O', 'pain-B-Disease', 'should-O', 'also-O', 'be-O', 'considered-O', 'before-O', 'ascribing-O', 'this-O', 'complaint-O', 'to-O', 'osteoporosis-B-Disease']
['Cerebrospinal-O', 'fluid-O', 'penetration-O', 'of-O', 'high-O', ',-O', 'dose-O', 'daptomycin-B-Chemical', 'in-O', 'suspected-O', 'Staphylococcus-O', 'aureus-O', 'meningitis-B-Disease', '.-O']
['OBJECTIVE-O', ':-O', 'To-O', 'report-O', 'a-O', 'case-O', 'of-O', 'methicillin-B-Chemical', ',-O', 'sensitive-O', 'Staphylococcus-O', 'aureus-O', '(-O', 'MSSA-O', ')-O', 'bacteremia-B-Disease', 'with-O', 'suspected-O', 'MSSA-O', 'meningitis-B-Disease', 'treated-O', 'with-O', 'high-O', ',-O', 'dose-O', 'daptomycin-B-Chemical', 'assessed-O', 'with-O', 'concurrent-O', 'serum-O', 'and-O', 'cerebrospinal-O', 'fluid-O', '(-O', 'CSF-O', ')-O', 'concentrations-O', '.-O']
['CASE-O', 'SUMMARY-O', ':-O', 'A-O', '54-O', ',-O', 'year-O', ',-O', 'old-O', 'male-O', 'presented-O', 'to-O', 'the-O', 'emergency-O', 'department-O', 'with-O', 'generalized-O', 'weakness-O', 'and-O', 'presumed-O', 'health-O', ',-O', 'care-O', ',-O', 'associated-O', 'pneumonia-B-Disease', 'shown-O', 'on-O', 'chest-O', 'radiograph-O', '.-O']
['Treatment-O', 'was-O', 'empirically-O', 'initiated-O', 'with-O', 'vancomycin-B-Chemical', ',-O', 'levofloxacin-B-Chemical', ',-O', 'and-O', 'piperacillin-B-Chemical', '/-O', 'tazobactam-B-Chemical', '.-O']
['Blood-O', 'cultures-O', 'revealed-O', 'S-B-Disease', '.-O']
['aureus-O', 'susceptible-O', 'to-O', 'oxacillin-B-Chemical', '.-O']
['Empiric-O', 'antibiotic-O', 'treatment-O', 'was-O', 'narrowed-O', 'to-O', 'nafcillin-B-Chemical', 'on-O', 'day-O', '4-O', '.-O']
['On-O', 'day-O', '8-O', ',-O', 'the-O', 'patient-O', 'developed-O', 'acute-B-Disease', 'renal-I-Disease', 'failure-I-Disease', '(-O', 'serum-O', 'creatinine-B-Chemical', '1-O', '.-O']
['9-O', 'mg-O', '/-O', 'dL-O', ',-O', 'increased-O', 'from-O', '1-O', '.-O']
['2-O', 'mg-O', '/-O', 'dL-O', 'the-O', 'previous-O', 'day-O', 'and-O', '0-O', '.-O']
['8-O', 'mg-O', '/-O', 'dL-O', 'on-O', 'admission-O', ')-O', 'The-O', 'patient-O', 'x-O', 's-O', 'Glasgow-O', 'Coma-O', 'Score-O', 'was-O', '3-O', ',-O', 'with-O', 'normal-O', 'findings-O', 'shown-O', 'on-O', 'computed-O', 'tomography-O', 'scan-O', 'of-O', 'the-O', 'head-O', '72-O', 'hours-O', 'following-O', 'an-O', 'episode-O', 'of-O', 'cardiac-B-Disease', 'arrest-I-Disease', 'on-O', 'day-O', '10-O', '.-O']
['The-O', 'patient-O', 'experienced-O', 'relapsing-O', 'MSSA-B-Disease', 'bacteremia-B-Disease', 'on-O', 'day-O', '9-O', ',-O', 'increasing-O', 'the-O', 'suspicion-O', 'for-O', 'a-O', 'central-O', 'nervous-O', 'system-O', '(-O', 'CNS-O', ')-O', 'infection-O', '.-O']
['Nafcillin-B-Chemical', 'was-O', 'discontinued-O', 'and-O', 'daptomycin-B-Chemical', '9-O', 'mg-O', '/-O', 'kg-O', 'daily-O', 'was-O', 'initiated-O', 'for-O', 'suspected-O', 'meningitis-B-Disease', 'and-O', 'was-O', 'continued-O', 'until-O', 'the-O', 'patient-O', 'x-O', 's-O', 'death-B-Disease', 'on-O', 'day-O', '16-O', '.-O']
['Daptomycin-B-Chemical', 'serum-O', 'and-O', 'CSF-O', 'trough-O', 'concentrations-O', 'were-O', '11-O', '.-O']
['21-O', 'ug-O', '/-O', 'mL-O', 'and-O', '0-O', '.-O']
['52-O', 'ug-O', '/-O', 'mL-O', ',-O', 'respectively-O', ',-O', 'prior-O', 'to-O', 'the-O', 'third-O', 'dose-O', '.-O']
['Lumbar-O', 'puncture-O', 'results-O', 'were-O', 'inconclusive-O', 'and-O', 'no-O', 'further-O', 'blood-O', 'cultures-O', 'were-O', 'positive-O', 'for-O', 'MSSA-B-Chemical', '.-O']
['Creatine-B-Chemical', 'kinase-O', 'levels-O', 'were-O', 'normal-O', 'prior-O', 'to-O', 'daptomycin-B-Chemical', 'therapy-O', 'and-O', 'were-O', 'not-O', 'reassessed-O', '.-O']
['DISCUSSION-O', ':-O', 'Daptomycin-B-Chemical', 'was-O', 'initiated-O', 'in-O', 'our-O', 'patient-O', 'secondary-O', 'to-O', 'possible-O', 'nafcillin-B-Chemical', ',-O', 'induced-O', 'acute-O', 'interstitial-B-Disease', 'nephritis-I-Disease', 'and-O', 'relapsing-O', 'bacteremia-B-Disease', '.-O']
['At-O', 'a-O', 'dose-O', 'of-O', '9-O', 'mg-O', '/-O', 'kg-O', ',-O', 'resultant-O', 'penetration-O', 'of-O', '5-O', '%-O', 'was-O', 'higher-O', 'than-O', 'in-O', 'previous-O', 'reports-O', ',-O', 'more-O', 'consistent-O', 'with-O', 'inflamed-O', 'meninges-B-Disease', '.-O']
['CONCLUSIONS-O', ':-O', 'High-O', ',-O', 'dose-O', 'daptomycin-B-Chemical', 'may-O', 'be-O', 'an-O', 'alternative-O', 'option-O', 'for-O', 'MSSA-B-Disease', 'bacteremia-B-Disease', 'with-O', 'or-O', 'without-O', 'a-O', 'CNS-B-Disease', 'source-O', 'in-O', 'patients-O', 'who-O', 'have-O', 'failed-O', 'or-O', 'cannot-O', 'tolerate-O', 'standard-O', 'therapy-O', '.-O']
['Further-O', 'clinical-O', 'evaluation-O', 'in-O', 'patients-O', 'with-O', 'confirmed-O', 'meningitis-B-Disease']
['The-O', 'role-O', 'of-O', 'nitric-B-Chemical', 'oxide-I-Chemical', 'in-O', 'convulsions-B-Disease', 'induced-O', 'by-O', 'lindane-B-Chemical', 'in-O', 'rats-O', '.-O']
['Lindane-B-Chemical', 'is-O', 'an-O', 'organochloride-O', 'pesticide-O', 'and-O', 'scabicide-O', '.-O']
['It-O', 'evokes-O', 'convulsions-B-Disease', 'mainly-O', 'trough-O', 'the-O', 'blockage-O', 'of-O', 'GABA-B-Chemical', '(-O', 'A-O', ')-O', 'receptors-O', '.-O']
['Nitric-O', 'oxide-B-Chemical', '(-O', 'NO-B-Chemical', '),', 'gaseous-O', 'neurotransmitter-O', ',-O', 'has-O', 'contradictor-O', 'role-O', 'in-O', 'epileptogenesis-O', 'due-O', 'to-O', 'opposite-O', 'effects-O', 'of-O', 'L-arginine-B-Chemical', ',-O', 'precursor-O', 'of-O', 'NO-B-Chemical', 'syntheses-O', '(-O', 'NOS-O', '),', 'and-O', 'L-NAME-B-Chemical', '(-O', 'NOS-O', 'inhibitor-O', ')', 'observed-O', 'in-O', 'different-O', 'epilepsy-O', 'models-O', '.-O']
['The-O', 'aim-O', 'of-O', 'the-O', 'current-O', 'study-O', 'was-O', 'to-O', 'determine-O', 'the-O', 'effects-O', 'of-O', 'NO-B-Chemical', 'on-O', 'the-O', 'behavioral-O', 'and-O', 'EEG-O', 'characteristics-O', 'of-O', 'lindane-B-Chemical', ',-O', 'induced-O', 'epilepsy-B-Disease', 'in-O', 'male-O', 'Wistar-O', 'albino-O', 'rats-O', '.-O']
['The-O', 'administration-O', 'of-O', 'L-arginine-B-Chemical', '(-O', '600-O', ',-O', '800-O', 'and-O', '1000-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', ')-O', 'in-O', 'dose-O', ',-O', 'dependent-O', 'manner-O', 'significantly-O', 'increased-O', 'convulsion-B-Disease', 'incidence-O', 'and-O', 'severity-O', 'and-O', 'shortened-O', 'latency-O', 'time-O', 'to-O', 'first-O', 'convulsion-B-Disease', 'elicited-O', 'by-O', 'lower-O', 'lindane-B-Chemical', 'dose-O', '(-O', '4-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', ').-O', 'On-O', 'the-O', 'contrary-O', ',-O', 'pretreatment-O', 'with-O', 'L-NAME-B-Chemical', '(-O', '500-O', ',-O', '700-O', 'and-O', '900-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', ')-O', 'decreased-O', 'convulsion-B-Disease', 'incidence-O', 'and-O', 'severity-O', 'and-O', 'prolonged-O', 'latency-O', 'time-O', 'to-O', 'convulsion-B-Disease', 'following-O', 'injection-O', 'with-O', 'a-O', 'convulsive-O', 'dose-O', 'of-O', 'lindane-B-Chemical', '(-O', '8-O', 'mg-O', '/-O', 'kg-O', ',-O', 'i-O', '.-O']
['p-O', ').-O', 'EEG-O', 'analyses-O', 'showed-O', 'increase-O', 'of-O', 'number-O', 'and-O', 'duration-O', 'of-O', 'ictal-O', 'periods-O', 'in-O', 'EEG-O', 'of-O', 'rats-O', 'receiving-O', 'l-arginine-B-Chemical', 'prior-O', 'to-O', 'lindane-B-Chemical', 'and-O', 'decrease-O', 'of-O', 'this-O', 'number-O', 'in-O', 'rats-O', 'pretreated-O', 'with-O', 'L-NAME-B-Chemical', '.-O']
['These-O', 'results-O', 'support-O', 'the-O', 'conclusion-O', 'that-O', 'NO-B-Chemical', 'plays-O', 'a-O', 'role-O', 'of-O', 'endogenous-O', 'convulsant-O', 'in-O', 'rat-O', 'model-O', 'of-O', 'lindane-B-Chemical', 'seizures-B-Disease']
['Long-O', ',-O', 'term-O', 'oral-O', 'galactose-B-Chemical', 'treatment-O', 'prevents-O', 'cognitive-O', 'deficits-I-Disease', 'in-O', 'male-O', 'Wistar-O', 'rats-O', 'treated-O', 'intracerebroventricularly-O', 'with-O', 'streptozotocin-B-Chemical', '.-O']
['Basic-O', 'and-O', 'clinical-O', 'research-O', 'has-O', 'demonstrated-O', 'that-O', 'dementia-B-Disease', 'of-O', 'sporadic-O', 'Alzheimer-B-Disease', 'disease-I-Disease', '(', 'sAD-O', ')-O', 'type-O', 'is-O', 'associated-O', 'with-O', 'dysfunction-O', 'of-O', 'the-O', 'insulin-B-Chemical', ',', 'receptor-O', '(', 'IR-O', ')-O', 'system-O', 'followed-O', 'by-O', 'decreased-O', 'glucose-B-Chemical', 'transport-O', 'via-O', 'glucose-B-Chemical', 'transporter-O', 'GLUT4-B-Chemical', 'and-O', 'decreased-O', 'glucose-B-Chemical', 'metabolism-O', 'in-O', 'brain-O', 'cells-O', '.-O']
['An-O', 'alternative-O', 'source-O', 'of-O', 'energy-O', 'is-O', 'd-galactose-B-Chemical', '(-O', 'the-O', 'C-O', ',-O', '4-O', ',-O', 'epimer-O', 'of-O', 'd-glucose-B-Chemical', ')-O', 'which-O', 'is-O', 'transported-O', 'into-O', 'the-O', 'brain-O', 'by-O', 'insulin-B-Chemical', ',-O', 'independent-O', 'GLUT3-O', 'transporter-O', 'where-O', 'it-O', 'might-O', 'be-O', 'metabolized-O', 'to-O', 'glucose-B-Chemical', 'via-O', 'the-O', 'Leloir-O', 'pathway-O', '.-O']
['Exclusively-O', 'parenteral-O', 'daily-O', 'injections-O', 'of-O', 'galactose-B-Chemical', 'induce-O', 'memory-O', 'deterioration-O', 'in-O', 'rodents-O', 'and-O', 'are-O', 'used-O', 'to-O', 'generate-O', 'animal-O', 'aging-O', 'model-O', ',-O', 'but-O', 'the-O', 'effects-O', 'of-O', 'oral-O', 'galactose-B-Chemical', 'treatment-O', 'on-O', 'cognitive-O', 'functions-O', 'have-O', 'never-O', 'been-O', 'tested-O', '.-O']
['We-O', 'have-O', 'investigated-O', 'the-O', 'effects-O', 'of-O', 'continuous-O', 'daily-O', 'oral-O', 'galactose-B-Chemical', '(-O', '200-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', ')-O', 'treatment-O', 'on-O', 'cognitive-O', 'deficits-O', 'in-O', 'streptozotocin-B-Chemical', ',-O', 'induced-O', '(-O', 'STZ-B-Chemical', ',-O', 'icv-O', ')-O', 'rat-O', 'model-O', 'of-O', 'sAD-B-Disease', ',-O', 'tested-O', 'by-O', 'Morris-O', 'Water-O', 'Maze-O', 'and-O', 'Passive-O', 'Avoidance-O', 'test-O', ',-O', 'respectively-O', '.-O']
['One-O', 'month-O', 'of-O', 'oral-O', 'galactose-B-Chemical', 'treatment-O', 'initiated-O', 'immediately-O', 'after-O', 'the-O', 'STZ-B-Chemical', ',-O', 'icv-O', 'administration-O', ',-O', 'successfully-O', 'prevented-O', 'development-O', 'of-O', 'the-O', 'STZ-B-Chemical', ',-O', 'icv-O', ',-O', 'induced-O', 'cognitive-B-Disease', 'deficits-I-Disease', '.-O']
['Beneficial-O', 'effect-O', 'of-O', 'oral-O', 'galactose-B-Chemical', 'was-O', 'independent-O', 'of-O', 'the-O', 'rat-O', 'age-O', 'and-O', 'of-O', 'the-O', 'galactose-B-Chemical', 'dose-O', 'ranging-O', 'from-O', '100-O', 'to-O', '300-O', 'mg-O', '/-O', 'kg-O', '/-O', 'day-O', '.-O']
['Additionally-O', ',-O', 'oral-O', 'galactose-B-Chemical', 'administration-O', 'led-O', 'to-O', 'the-O', 'appearance-O', 'of-O', 'galactose-B-Chemical', 'in-O', 'the-O', 'blood-O', '.-O']
['The-O', 'increase-O', 'of-O', 'galactose-B-Chemical', 'concentration-O', 'in-O', 'the-O', 'cerebrospinal-O', 'fluid-O', 'was-O', 'several-O', 'times-O', 'lower-O', 'after-O', 'oral-O', 'than-O', 'after-O', 'parenteral-O', 'administration-O', 'of-O', 'the-O', 'same-O', 'galactose-B-Chemical', 'dose-O', '.-O']
['Oral-O', 'galactose-B-Chemical', 'exposure-O', 'might-O', 'have-O', 'beneficial-O', 'effects-O', 'on-O', 'learning-O', 'and-O', 'memory-O', 'ability-O', 'and-O', 'could-O', 'be-O', 'worth-O', 'investigating-O', 'for-O', 'improvement-O', 'of-O', 'cognitive-O', 'deficits-O', 'associated-O', 'with-O', 'glucose-B-Chemical', 'hypometabolism-O', 'in-O', 'AD-B-Disease']