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[]
["Table1  Patient characteristics according to tumour subtype",{"$nulls":16},"Table 3  Multivariate Analysis of Prognostic Factors"]
["Characteristics","HR+/HER2-","HR+/HER2+","HR-/HER2-","HR-/HER2+","Total","P value",{"$nulls":10},"Characteristics","P value","HR","95%CI for HR"]
[null,"2146(63.42)","672(19.86)","316(9.34)","250(7.39)","3384(100)",{"$nulls":11},"Age at diagnosis"]
["Year of diagnosis",{"$nulls":5},0.981,{"$nulls":10},"40-44 years",null,"Reference"]
[2012,"422(19.66)","133(19.79)","55(17.41)","51(20.40)","661(19.53)",{"$nulls":11},"45-49 years",0.542,0.932,"0.741-1.170"]
[2013,"441(20.55)","138(20.54)","68(21.52)","52(20.80)","699(20.66)",{"$nulls":11},"50-54 years",0.878,1.017,"0.821-1.260"]
[2014,"425(19.80)","125(18.60)","65(20.57)","46(18.40)","661(19.53)",{"$nulls":11},"55-59 years",0.024,1.27,"1.032-1.562"]
[2015,"428(19.94)","143(21.28)","59(18.67)","45(18.00)","675(19.95)",{"$nulls":11},"Race"]
[2016,"430(20.04)","133(19.79)","69(21.84)","56(22.40)","688(20.33)",{"$nulls":11},"White",null,"Reference"]
["Age at diagnosis",{"$nulls":5},0.221,{"$nulls":10},"Black",0.001,1.317,"1.127-1.540"]
["40-44 years","283(13.19)","107(15.92)","31(9.81)","28(11.20)","449(13.27)",{"$nulls":11},"Other a",0.128,1.192,"0.951-1.495"]
["45-49 years","465(21.67)","128(19.05)","65(20.57)","50(20.00)","708(20.92)",{"$nulls":11},"Marital status"]
["50-54 years","638(29.73)","202(30.06)","110(34.81)","81(32.40)","1031(30.47)",{"$nulls":11},"Single",null,"Reference"]
["55-59 years","760(35.41)","235(34.97)","110(34.81)","91(36.40)","1196(35.34)",{"$nulls":11},"Married",0.008,0.819,"0.707-0.949"]
["Race",{"$nulls":5},"<0.001",{"$nulls":10},"Other b",0.13,0.871,"0.728-1.042"]
["White","1574(73.35)","481(71.58)","218(68.99)","170(68.00)","2443(72.19)",{"$nulls":11},"Insurance(yes vs no)","<0.001",0.587,"0.459-0.751"]
["Black","353(16.45)","127(18.90)","81(25.63)","43(17.20)","604(17.85)",{"$nulls":11},"Histology"]
["Other a","211(9.83)","64(9.52)","16(5.06)","33(13.20)","324(9.57)",{"$nulls":11},"Ductal",null,"Reference"]
["Unknown","8(0.37)","0(0.00)","1(0.32)","4(1.60)","13(0.38)",{"$nulls":11},"Lobular",0.744,1.041,"0.820-1.321"]
["Marital status",{"$nulls":5},0.771,{"$nulls":10},"Others",0.356,1.105,"0.894-1.365"]
["Single","620(28.89)","189(28.13)","89(28.16)","73(29.20)","971(28.69)",{"$nulls":11},"Laterality"]
["Married","1049(48.88)","342(50.89)","150(47.47)","113(45.20)","1654(48.88)",{"$nulls":11},"Right",null,"Reference"]
["Other b","377(17.57)","111(16.52)","64(20.25)","47(18.80)","599(17.70)",{"$nulls":11},"Left",0.506,1.043,"0.921-1.182"]
["Unknown","100(4.66)","30(4.46)","13(4.11)","17(6.80)","160(4.73)",{"$nulls":11},"Bilateral, single primary",0.177,2.21,"0.894-1.365"]
["Insurance",{"$nulls":5},0.49,{"$nulls":10},"Grade"]
["Insured","104(4.85)","42(6.25)","17(5.38)","11(4.40)","174(5.14)",{"$nulls":11},"I",null,"Reference"]
["Uninsured","2027(94.45)","623(92.71)","297(93.99)","235(94.00)","3182(94.03)",{"$nulls":11},"II",0.309,1.147,"0.881-1.492"]
["Unknown","15(0.70)","7(1.04)","2(0.63)","4(1.60)","28(0.83)",{"$nulls":11},"III or IV","<0.001",1.96,"1.491-2.577"]
["Grade",{"$nulls":5},"<0.001",{"$nulls":10},"Tumour subtype"]
["I","247(11.51)","21(3.13)","4(1.27)","2(0.80)","274(8.10)",{"$nulls":11},"HR+/HER2-",null,"Reference"]
["II","1017(47.39)","244(36.31)","64(20.25)","67(26.80)","1392(41.13)",{"$nulls":11},"HR+/HER2+",0.002,0.631,"0.474-0.839"]
["III or IV","619(28.84)","334(49.70)","230(72.78)","149(59.60)","1332(39.36)",{"$nulls":11},"HR-/HER2-","<0.001",2.808,"2.169-3.634"]
["Unknown","263(12.26)","73(10.86)","18(5.70)","32(12.80)","32(12.80)",{"$nulls":11},"HR-/HER2+",0.258,0.716,"0.401-1.277"]
["Histology",{"$nulls":5},"<0.001",{"$nulls":10},"Site of metastases"]
["Ductal","1571(73.21)","559(83.18)","277(87.66)","216(86.40)","2623(77.51)",{"$nulls":11},"Lung(yes vs no)",0.02,1.378,"1.188-1.598"]
["Lobular","353(16.45)","28(4.17)","13(4.11)","6(2.40)","400(11.82)",{"$nulls":11},"Live(yes vs no)","<0.001",2.085,"1.795-2.422"]
["Others","222(10.34)","85(12.65)","26(8.23)","28(11.20)","361(10.67)",{"$nulls":11},"Brain(yes vs no)","<0.001",1.903,"1.542-2.248"]
["Laterality",{"$nulls":5},0.153,{"$nulls":10},"Surgery(yes vs no)","<0.001",0.504,"0.431-0.590"]
["Right","1054(49.11)","330(49.11)","156(49.37)","102(40.80)","1642(48.52)",{"$nulls":11},"HR+/HER2- * multi-metastases",null,"Reference"]
["Left","1070(49.86)","337(50.15)","155(49.05)","146(58.40)","1708(50.47)",{"$nulls":11},"HR+/HER2+ * multi-metastases",0.045,0.694,"0.485-0.992"]
["Bilateral, single primary","5(0.23)","4(0.60)","2(0.63)","1(0.40)","12(0.35)",{"$nulls":11},"HR-/HER2- * multi-metastases",0.717,0.941,"0.675-1.310"]
["Unknown","17(0.79)","1(0.15)","3(0.95)","1(0.40)","22(0.65)",{"$nulls":11},"HR-/HER2+ * multi-metastases",0.564,0.828,"0.437-1.572"]
["Lung metastases",{"$nulls":5},"<0.001",{"$nulls":10},"Next step"]
["No","1643(76.56)","452(67.26)","216(68.35)","158(63.20)","2469(72.96)",{"$nulls":11},"White*HR+/HER2-",null,"Reference"]
["Yes","449(20.92)","205(30.51)","96(30.38)","89(35.60)","839(24.79)",{"$nulls":11},"Black*HR+/HER2+",0.366,0.821,"0.536-1.258"]
["Unknown","54(2.52)","15(2.23)","4(1.27)","3(1.20)","76(2.25)",{"$nulls":11},"Other a*HR+/HER2+",0.652,0.862,"0.453-1.641"]
["Liver metastases",{"$nulls":5},"<0.001",{"$nulls":10},"Black*HR-/HER2-",0.323,0.817,"0.546-1.220"]
["No","1691(78.80)","418(62.20)","208(65.82)","132(52.80)","2449(72.37)",{"$nulls":11},"Other a*HR-/HER2-",0.299,1.508,"0.695-3.271"]
["Yes","423(19.71)","244(36.31)","101(31.96)","155(46.00)","883(26.09)",{"$nulls":11},"Black*HR-/HER2+",0.696,0.881,"0.466-1.664"]
["Unknown","32(1.49)","10(1.49)","7(2.22)","3(1.20)","52(1.54)",{"$nulls":11},"Other a*HR-/HER2+",0.368,0.701,"0.323-1.521"]
["Brain metastases",{"$nulls":5},"<0.001"]
["No","1992(92.82)","595(88.54)","263(83.23)","214(85.60)","3064(90.54)"]
["Yes","107(4.99)","62(9.23)","44(13.92)","31(12.40)","244(7.21)"]
["Unknown","47(2.19)","15(2.23)","9(2.85)","5(2.00)","76(2.25)"]
["Only bone metastases",{"$nulls":5},"<0.001"]
["No","748(34.86)","360(53.57)","170(53.80)","168(67.20)","1446(42.73)"]
["Yes","1326(61.79)","300(44.64)","140(44.30)","80(32.00)","1846(54.55)"]
["Unknown","72(3.36)","12(1.79)","6(1.90)","2(0.80)","21(2.72)"]
["Surgery",{"$nulls":5},0.971]
["No","1541(71.81)","489(72.77)","225(71.20)","180(72.00)","2435(71.96)"]
["Yes","588(27.40)","179(26.64)","88(27.85)","68(27.20)","923(27.28)"]
["Unknown","17(0.79)","4(0.60)","3(0.95)","2(0.80)","26(0.77)"]
["Breast cancer -specific death",{"$nulls":5},"<0.001"]
["No","1502(69.99)","504(75.00)","140(44.30)","165(66.00)","2311(68.29)"]
["Yes","644(30.01)","168(25.00)","176(55.70)","85(34.00)","1073(31.71)"]
["Status",{"$nulls":5},"<0.001"]
["Alive","1350(62.91)","474(70.54)","92(29.11)","153(61.20)","2069(61.14)"]
["Dead","796(37.09)","198(29.46)","224(70.89)","97(38.80)","1315(38.86)"]
["Other a (American Indian/AK Native, Asian/Pacific Islander)"]
["Other b (Divorced/Widowed/Separated)"]
["Unknown patients are excluded from the comparative analysis."]
[]
[]
[]
[]
["Table 2  Univariate Analysis of Prognostic Factors"]
["Characteristics","Median OS","P value","HR","95%CI for HR"]
["Age at diagnosis",null,"<0.001"]
["40-44 years",42,null,"Reference"]
["45-49 years",41,null,1.013,"0.829-1.237"]
["50-54 years",39,null,1.103,"0.915-1.329"]
["55-59 years",32,null,1.364,"1.139-1.634"]
["Race",null,"<0.001"]
["White",41,null,"Reference"]
["Black",28,null,1.498,"1.315-1.707"]
["Other a",38,null,1.003,"0.824-1.220"]
["Marital status",null,"<0.001"]
["Single",32,null,"Reference"]
["Married",42,null,0.723,"0.638-0.819"]
["Other b",35,null,0.903,"0.772-1.057"]
["Insurance",null,"<0.001"]
["Uninsured",26,null,"Reference"]
["Insured",38,null,0.633,"0.513-0.781"]
["Grade",null,"<0.001"]
["I",48,null,"Reference"]
["II",44,null,1.214,"0.953-1.547"]
["III or IV",28,null,2.071,"1.634-2.625"]
["Histology",null,0.003]
["Ductal",36,null,"Reference"]
["Lobular",44,null,0.748,"0.624-0.897"]
["Others",40,null,0.856,"0.713-1.028"]
["Laterality",null,0.084]
["Right",38,null,"Reference"]
["Left",38,null,1.058,"0.949-1.179"]
["Bilateral, single primary",13,null,2.254,"1.008-5.039"]
["Tumour subtype",null,"<0.001"]
["HR+/HER2-",39,null,"Reference"]
["HR+/HER2+",52,null,0.747,"0.640-0.873"]
["HR-/HER2-",11,null,3.571,"3.071-4.152"]
["HR-/HER2+",35,null,1.132,"0.917-1.397"]
["Bone+Lung metastases",null,"<0.001"]
["No",42,null,"Reference"]
["Yes",23,null,1.888,"1.679-2.123"]
["Bone+Liver metastases",null,"<0.001"]
["No",44,null,"Reference"]
["Yes",22,null,2.182,"1.950-2.443"]
["Bone+Brain metastases",null,"<0.001"]
["No",40,null,"Reference"]
["Yes",14,null,2.674,"2.245-3.184"]
["Only bone metastases",null,"<0.001"]
["No",46,null,"Reference"]
["Yes",24,null,2.29,"2.04-2.559"]
["Surgery",null,"<0.001"]
["No",32,null,"Reference"]
["Yes",52,null,0.496,"0.433-0.568"]
["Other a (American Indian/AK Native, Asian/Pacific Islander)"]
["Other b (Divorced/Widowed/Separated)"]
[]
[]
[]
["Table 3  Multivariate Analysis of Prognostic Factors"]
["Characteristics","P value","HR","95%CI for HR"]
["Age at diagnosis"]
["40-44 years",null,"Reference"]
["45-49 years",0.542,0.932,"0.741-1.170"]
["50-54 years",0.878,1.017,"0.821-1.260"]
["55-59 years",0.024,1.27,"1.032-1.562"]
["Race"]
["White",null,"Reference"]
["Black",0.001,1.317,"1.127-1.540"]
["Other a",0.128,1.192,"0.951-1.495"]
["Marital status"]
["Single",null,"Reference"]
["Married",0.008,0.819,"0.707-0.949"]
["Other b",0.13,0.871,"0.728-1.042"]
["Insurance(yes vs no)","<0.001",0.587,"0.459-0.751"]
["Histology"]
["Ductal",null,"Reference"]
["Lobular",0.744,1.041,"0.820-1.321"]
["Others",0.356,1.105,"0.894-1.365"]
["Laterality"]
["Right",null,"Reference"]
["Left",0.506,1.043,"0.921-1.182"]
["Bilateral, single primary",0.177,2.21,"0.894-1.365"]
["Grade"]
["I",null,"Reference"]
["II",0.309,1.147,"0.881-1.492"]
["III or IV","<0.001",1.96,"1.491-2.577"]
["Tumour subtype"]
["HR+/HER2-",null,"Reference"]
["HR+/HER2+",0.002,0.631,"0.474-0.839"]
["HR-/HER2-","<0.001",2.808,"2.169-3.634"]
["HR-/HER2+",0.258,0.716,"0.401-1.277"]
["Site of metastases"]
["Lung(yes vs no)",0.02,1.378,"1.188-1.598"]
["Live(yes vs no)","<0.001",2.085,"1.795-2.422"]
["Brain(yes vs no)","<0.001",1.903,"1.542-2.248"]
["Surgery(yes vs no)","<0.001",0.504,"0.431-0.590"]
["HR+/HER2- * multi-metastases",null,"Reference"]
["HR+/HER2+ * multi-metastases",0.045,0.694,"0.485-0.992"]
["HR-/HER2- * multi-metastases",0.717,0.941,"0.675-1.310"]
["HR-/HER2+ * multi-metastases",0.564,0.828,"0.437-1.572"]
["Next step"]
["White*HR+/HER2-",null,"Reference"]
["Black*HR+/HER2+",0.366,0.821,"0.536-1.258"]
["Other a*HR+/HER2+",0.652,0.862,"0.453-1.641"]
["Black*HR-/HER2-",0.323,0.817,"0.546-1.220"]
["Other a*HR-/HER2-",0.299,1.508,"0.695-3.271"]
["Black*HR-/HER2+",0.696,0.881,"0.466-1.664"]
["Other a*HR-/HER2+",0.368,0.701,"0.323-1.521"]
["Other a (American Indian/AK Native, Asian/Pacific Islander)\n"]
["Other b (Divorced/Widowed/Separated)"]

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