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{"sheet":"Module GO enrichment analysis","index":1,"n_rows":431,"n_cols":14,"rows_kept":431}
["module","modSize","bkgrModSize","rank","enrichmentP","BonferoniP","nModGenesInTerm","fracOfBkgrModSize","fracOfBkgrTermSize","bkgrTermSize","termID","termOntology","termName","termDefinition"]
["black",483,59,1,0.001205705,1,16,0.271186441,0.071748879,223,"GO:0048468","BP","cell development","The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate."]
["black",483,59,2,0.001728043,1,11,0.186440678,0.087301587,126,"GO:0030030","BP","cell projection organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon."]
["black",483,59,3,0.002047483,1,8,0.13559322,0.108108108,74,"GO:0048812","BP","neuron projection morphogenesis","The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites."]
["black",483,59,4,0.004057941,1,10,0.169491525,0.083333333,120,"GO:0000902","BP","cell morphogenesis","The developmental process in which the size or shape of a cell is generated and organized."]
["black",483,59,5,0.00406175,1,7,0.118644068,0.107692308,65,"GO:0007409","BP","axonogenesis","De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells."]
["black",483,59,6,0.004419566,1,9,0.152542373,0.088235294,102,"GO:0031175","BP","neuron projection development","The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)."]
["black",483,59,7,0.005135556,1,5,0.084745763,0.138888889,36,"GO:0005764","CC","lysosome","A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions."]
["black",483,59,8,0.005242977,1,7,0.118644068,0.102941176,68,"GO:0061564","BP","axon development","The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)."]
["black",483,59,9,0.006163753,1,7,0.118644068,0.1,70,"GO:0048667","BP","cell morphogenesis involved in neuron differentiation","The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron."]
["black",483,59,10,0.006508121,1,5,0.084745763,0.131578947,38,"GO:0007411","BP","axon guidance","The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues."]
["blue",624,95,1,1.428587E-3,1,21,0.221052632,0.101449275,207,"GO:0007399","BP","nervous system development","The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state."]
["blue",624,95,2,0.002606762,1,10,0.105263158,0.142857143,70,"GO:0048667","BP","cell morphogenesis involved in neuron differentiation","The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron."]
["blue",624,95,3,0.002668005,1,2,0.021052632,1,2,"GO:0030285","CC","integral component of synaptic vesicle membrane","The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane."]
["blue",624,95,4,0.004566277,1,4,0.042105263,0.285714286,14,"GO:0030658","CC","transport vesicle membrane","The lipid bilayer surrounding a transport vesicle."]
["blue",624,95,5,0.005049127,1,6,0.063157895,0.1875,32,"GO:0048193","BP","Golgi vesicle transport","The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles."]
["blue",624,95,6,0.005315057,1,9,0.094736842,0.138461538,65,"GO:0007409","BP","axonogenesis","De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells."]
["blue",624,95,7,0.005590223,1,11,0.115789474,0.122222222,90,"GO:0000904","BP","cell morphogenesis involved in differentiation","The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history."]
["blue",624,95,8,0.00627567,1,3,0.031578947,0.375,8,"GO:0032387","BP","negative regulation of intracellular transport","Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells."]
["blue",624,95,9,0.007196975,1,9,0.094736842,0.132352941,68,"GO:0061564","BP","axon development","The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)."]
["blue",624,95,10,0.007662661,1,4,0.042105263,0.25,16,"GO:0006888","BP","ER to Golgi vesicle-mediated transport","The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi."]
["brown",650,102,1,2.347292E-3,1,8,0.078431373,0.181818182,44,"GO:0016887","MF","ATPase activity","Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction."]
["brown",650,102,2,0.002974318,1,3,0.029411765,0.5,6,"GO:0008238","MF","exopeptidase activity","Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both."]
["brown",650,102,3,3.077916E-3,1,2,0.019607843,1,2,"GO:0001956","BP","positive regulation of neurotransmitter secretion","Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter."]
["brown",650,102,4,3.077916E-3,1,2,0.019607843,1,2,"GO:0004180","MF","carboxypeptidase activity","Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide."]
["brown",650,102,5,0.003185002,1,4,0.039215686,0.333333333,12,"GO:0042626","MF","ATPase activity, coupled to transmembrane movement of substances","Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane."]
["brown",650,102,6,0.008317729,1,7,0.068627451,0.162790698,43,"GO:0005813","CC","centrosome","A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle."]
["brown",650,102,7,0.008658037,1,8,0.078431373,0.148148148,54,"GO:0010008","CC","endosome membrane","The lipid bilayer surrounding an endosome."]
["brown",650,102,8,0.008896995,1,2,0.019607843,0.666666667,3,"GO:0031593","MF","polyubiquitin modification-dependent protein binding","Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein."]
["brown",650,102,9,0.008973014,1,47,0.460784314,0.074249605,633,"GO:0003824","MF","catalytic activity","Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."]
["brown",650,102,10,0.011043842,1,3,0.029411765,0.333333333,9,"GO:0008237","MF","metallopeptidase activity","Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]
["cyan",333,46,1,0.00359267,1,2,0.043478261,0.5,4,"GO:0004060","MF","arylamine N-acetyltransferase activity","Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine."]
["cyan",333,46,2,0.00359267,1,2,0.043478261,0.5,4,"GO:0035198","MF","miRNA binding","Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes."]
["cyan",333,46,3,0.00486728,1,13,0.282608696,0.053719008,242,"GO:0016740","MF","transferase activity","Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2."]
["cyan",333,46,4,0.008696899,1,2,0.043478261,0.333333333,6,"GO:0010812","BP","negative regulation of cell-substrate adhesion","Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules."]
["cyan",333,46,5,0.017931947,1,4,0.086956522,0.097560976,41,"GO:0004857","MF","enzyme inhibitor activity","Binds to and stops, prevents or reduces the activity of an enzyme."]
["cyan",333,46,6,0.021519048,1,5,0.108695652,0.076923077,65,"GO:0005730","CC","nucleolus","A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome."]
["cyan",333,46,7,0.024470428,1,2,0.043478261,0.2,10,"GO:0035195","BP","gene silencing by miRNA","Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA."]
["cyan",333,46,8,0.025136612,1,1,0.02173913,1,1,"GO:0000453","BP","enzyme-directed rRNA 2'-O-methylation","The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA."]
["cyan",333,46,9,0.025136612,1,1,0.02173913,1,1,"GO:0000466","BP","maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript."]
["cyan",333,46,10,0.025136612,1,1,0.02173913,1,1,"GO:0002317","BP","plasma cell differentiation","The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody."]
["darkgreen",222,29,1,1.427088E-3,1,2,0.068965517,0.5,4,"GO:0005583","CC","fibrillar collagen trimer","Any triple helical collagen trimer that forms fibrils."]
["darkgreen",222,29,2,0.008150548,1,2,0.068965517,0.222222222,9,"GO:0005518","MF","collagen binding","Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)."]
["darkgreen",222,29,3,0.012209751,1,2,0.068965517,0.181818182,11,"GO:0030199","BP","collagen fibril organization","Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix."]
["darkgreen",222,29,4,0.013037727,1,3,0.103448276,0.09375,32,"GO:0030198","BP","extracellular matrix organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix."]
["darkgreen",222,29,5,0.015846995,1,1,0.034482759,1,1,"GO:0006182","BP","cGMP biosynthetic process","The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate."]
["darkgreen",222,29,6,0.015846995,1,1,0.034482759,1,1,"GO:0006607","BP","NLS-bearing protein import into nucleus","The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope."]
["darkgreen",222,29,7,0.015846995,1,1,0.034482759,1,1,"GO:0006624","BP","vacuolar protein processing","Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes."]
["darkgreen",222,29,8,0.015846995,1,1,0.034482759,1,1,"GO:0007168","BP","receptor guanylyl cyclase signaling pathway","A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription."]
["darkgreen",222,29,9,0.015846995,1,1,0.034482759,1,1,"GO:0018400","BP","peptidyl-proline hydroxylation to 3-hydroxy-L-proline","The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase."]
["darkgreen",222,29,10,0.015846995,1,1,0.034482759,1,1,"GO:0032914","BP","positive regulation of transforming growth factor beta1 production","Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1."]
["darkgrey",213,31,1,0.009287276,1,2,0.064516129,0.222222222,9,"GO:0031122","BP","cytoplasmic microtubule organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell."]
["darkgrey",213,31,2,0.013892455,1,2,0.064516129,0.181818182,11,"GO:0043021","MF","ribonucleoprotein complex binding","Interacting selectively and non-covalently with any complex of RNA and protein."]
["darkgrey",213,31,3,0.016939891,1,1,0.032258065,1,1,"GO:0001961","BP","positive regulation of cytokine-mediated signaling pathway","Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway."]
["darkgrey",213,31,4,0.016939891,1,1,0.032258065,1,1,"GO:0007097","BP","nuclear migration","The directed movement of the nucleus to a specific location within a cell."]
["darkgrey",213,31,5,0.016939891,1,1,0.032258065,1,1,"GO:0009249","BP","protein lipoylation","The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine."]
["darkgrey",213,31,6,0.016939891,1,1,0.032258065,1,1,"GO:0019226","BP","transmission of nerve impulse","The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission."]
["darkgrey",213,31,7,0.016939891,1,1,0.032258065,1,1,"GO:0021819","BP","layer formation in cerebral cortex","The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex."]
["darkgrey",213,31,8,0.016939891,1,1,0.032258065,1,1,"GO:0030579","BP","ubiquitin-dependent SMAD protein catabolic process","The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome."]
["darkgrey",213,31,9,0.016939891,1,1,0.032258065,1,1,"GO:0042249","BP","establishment of planar polarity of embryonic epithelium","Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates."]
["darkgrey",213,31,10,0.016939891,1,1,0.032258065,1,1,"GO:0043622","BP","cortical microtubule organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell."]
["darkmagenta",155,18,1,0.003926086,1,2,0.111111111,0.2,10,"GO:0050729","BP","positive regulation of inflammatory response","Any process that activates or increases the frequency, rate or extent of the inflammatory response."]
["darkmagenta",155,18,2,0.009836066,1,1,0.055555556,1,1,"GO:0002227","BP","innate immune response in mucosa","Any process of the innate immune response that takes place in the mucosal tissues."]
["darkmagenta",155,18,3,0.009836066,1,1,0.055555556,1,1,"GO:0002882","BP","positive regulation of chronic inflammatory response to non-antigenic stimulus","Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus."]
["darkmagenta",155,18,4,0.009836066,1,1,0.055555556,1,1,"GO:0006307","BP","DNA dealkylation involved in DNA repair","The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT)."]
["darkmagenta",155,18,5,0.009836066,1,1,0.055555556,1,1,"GO:0008295","BP","spermidine biosynthetic process","The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane."]
["darkmagenta",155,18,6,0.009836066,1,1,0.055555556,1,1,"GO:0010575","BP","positive regulation of vascular endothelial growth factor production","Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor."]
["darkmagenta",155,18,7,0.009836066,1,1,0.055555556,1,1,"GO:0010753","BP","positive regulation of cGMP-mediated signaling","Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response."]
["darkmagenta",155,18,8,0.009836066,1,1,0.055555556,1,1,"GO:0016973","BP","poly(A)+ mRNA export from nucleus","The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm."]
["darkmagenta",155,18,9,0.009836066,1,1,0.055555556,1,1,"GO:0033388","BP","putrescine biosynthetic process from arginine","The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine."]
["darkmagenta",155,18,10,0.009836066,1,1,0.055555556,1,1,"GO:0033389","BP","putrescine biosynthetic process from arginine, using agmatinase","The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step."]
["darkolivegreen",120,16,1,0.00070612,1,2,0.125,0.4,5,"GO:0050764","BP","regulation of phagocytosis","Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material."]
["darkolivegreen",120,16,2,1.053776E-3,1,2,0.125,0.333333333,6,"GO:0009749","BP","response to glucose","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus."]
["darkolivegreen",120,16,3,1.053776E-3,1,2,0.125,0.333333333,6,"GO:0071333","BP","cellular response to glucose stimulus","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus."]
["darkolivegreen",120,16,4,0.001467762,1,2,0.125,0.285714286,7,"GO:0009743","BP","response to carbohydrate","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus."]
["darkolivegreen",120,16,5,3.097341E-3,1,2,0.125,0.2,10,"GO:0048477","BP","oogenesis","The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster."]
["darkolivegreen",120,16,6,0.003766347,1,2,0.125,0.181818182,11,"GO:0043204","CC","perikaryon","The portion of the cell soma (neuronal cell body) that excludes the nucleus."]
["darkolivegreen",120,16,7,0.004775671,1,3,0.1875,0.073170732,41,"GO:0043010","BP","camera-type eye development","The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field."]
["darkolivegreen",120,16,8,0.005287083,1,2,0.125,0.153846154,13,"GO:0007292","BP","female gamete generation","Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction."]
["darkolivegreen",120,16,9,0.005287083,1,2,0.125,0.153846154,13,"GO:0042593","BP","glucose homeostasis","Any process involved in the maintenance of an internal steady state of glucose within an organism or cell."]
["darkolivegreen",120,16,10,0.007044935,1,2,0.125,0.133333333,15,"GO:0006909","BP","phagocytosis","An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles."]
["darkorange",212,27,1,1.23558E-3,1,2,0.074074074,0.5,4,"GO:0002639","BP","positive regulation of immunoglobulin production","Any process that activates or increases the frequency, rate, or extent of immunoglobulin production."]
["darkorange",212,27,2,0.007082603,1,2,0.074074074,0.222222222,9,"GO:0016447","BP","somatic recombination of immunoglobulin gene segments","The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus."]
["darkorange",212,27,3,0.008772961,1,2,0.074074074,0.2,10,"GO:0030837","BP","negative regulation of actin filament polymerization","Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization."]
["darkorange",212,27,4,0.008772961,1,2,0.074074074,0.2,10,"GO:0051693","BP","actin filament capping","The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits."]
["darkorange",212,27,5,0.012634946,1,2,0.074074074,0.166666667,12,"GO:0002377","BP","immunoglobulin production","The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels."]
["darkorange",212,27,6,0.014754098,1,1,0.037037037,1,1,"GO:0001556","BP","oocyte maturation","A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization."]
["darkorange",212,27,7,0.014754098,1,1,0.037037037,1,1,"GO:0002230","BP","positive regulation of defense response to virus by host","Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication."]
["darkorange",212,27,8,0.014754098,1,1,0.037037037,1,1,"GO:0006348","BP","chromatin silencing at telomere","Repression of transcription of telomeric DNA by altering the structure of chromatin."]
["darkorange",212,27,9,0.014754098,1,1,0.037037037,1,1,"GO:0007130","BP","synaptonemal complex assembly","The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination."]
["darkorange",212,27,10,0.014754098,1,1,0.037037037,1,1,"GO:0007141","BP","male meiosis I","A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline."]
["darkred",188,31,1,0.003095144,1,8,0.258064516,0.051948052,154,"GO:0005783","CC","endoplasmic reticulum","The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)."]
["darkred",188,31,2,0.004130811,1,3,0.096774194,0.15,20,"GO:0032993","CC","protein-DNA complex","A macromolecular complex containing both protein and DNA molecules."]
["darkred",188,31,3,0.005533405,1,2,0.064516129,0.285714286,7,"GO:0030667","CC","secretory granule membrane","The lipid bilayer surrounding a secretory granule."]
["darkred",188,31,4,0.007869215,1,3,0.096774194,0.12,25,"GO:0042391","BP","regulation of membrane potential","Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane."]
["darkred",188,31,5,0.013892455,1,2,0.064516129,0.181818182,11,"GO:0000786","CC","nucleosome","A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures."]
["darkred",188,31,6,0.015147898,1,5,0.161290323,0.056179775,89,"GO:0005789","CC","endoplasmic reticulum membrane","The lipid bilayer surrounding the endoplasmic reticulum."]
["darkred",188,31,7,0.016496135,1,2,0.064516129,0.166666667,12,"GO:0035094","BP","response to nicotine","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus."]
["darkred",188,31,8,0.016939891,1,1,0.032258065,1,1,"GO:0001580","BP","detection of chemical stimulus involved in sensory perception of bitter taste","The series of events required for a bitter taste stimulus to be received and converted to a molecular signal."]
["darkred",188,31,9,0.016939891,1,1,0.032258065,1,1,"GO:0002037","BP","negative regulation of L-glutamate import across plasma membrane","Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell."]
["darkred",188,31,10,0.016939891,1,1,0.032258065,1,1,"GO:0006589","BP","octopamine biosynthetic process","The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species."]
["darkturquoise",221,35,1,0.00049806,1,3,0.085714286,0.333333333,9,"GO:0030674","MF","protein binding, bridging","The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way."]
["darkturquoise",221,35,2,0.002020681,1,3,0.085714286,0.214285714,14,"GO:0060090","MF","molecular adaptor activity","The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way."]
["darkturquoise",221,35,3,0.002492843,1,3,0.085714286,0.2,15,"GO:0043401","BP","steroid hormone mediated signaling pathway","A series of molecular signals mediated by a steroid hormone binding to a receptor."]
["darkturquoise",221,35,4,0.003096618,1,4,0.114285714,0.121212121,33,"GO:0010942","BP","positive regulation of cell death","Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death."]
["darkturquoise",221,35,5,0.003096618,1,4,0.114285714,0.121212121,33,"GO:0048545","BP","response to steroid hormone","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus."]
["darkturquoise",221,35,6,0.003096618,1,4,0.114285714,0.121212121,33,"GO:0071407","BP","cellular response to organic cyclic compound","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus."]
["darkturquoise",221,35,7,0.003428661,1,2,0.057142857,0.4,5,"GO:0001570","BP","vasculogenesis","The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes."]
["darkturquoise",221,35,8,0.003428661,1,2,0.057142857,0.4,5,"GO:0005070","MF","SH3/SH2 adaptor activity","Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)."]
["darkturquoise",221,35,9,0.003604905,1,5,0.142857143,0.089285714,56,"GO:0032870","BP","cellular response to hormone stimulus","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus."]
["darkturquoise",221,35,10,5.081304E-3,1,2,0.057142857,0.333333333,6,"GO:0030216","BP","keratinocyte differentiation","The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte."]
["green",450,82,1,0.000336117,1,3,0.036585366,0.75,4,"GO:0010586","BP","miRNA metabolic process","The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression."]
["green",450,82,2,0.001408925,1,4,0.048780488,0.333333333,12,"GO:0003205","BP","cardiac chamber development","The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart."]
["green",450,82,3,1.984422E-3,1,2,0.024390244,1,2,"GO:0003215","BP","cardiac right ventricle morphogenesis","The process in which the right cardiac ventricle is generated and organized."]
["green",450,82,4,1.984422E-3,1,2,0.024390244,1,2,"GO:0010587","BP","miRNA catabolic process","The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression."]
["green",450,82,5,1.984422E-3,1,2,0.024390244,1,2,"GO:0032971","BP","regulation of muscle filament sliding","Any process that modulates the frequency, rate or extent of muscle filament sliding."]
["green",450,82,6,1.984422E-3,1,2,0.024390244,1,2,"GO:0072182","BP","regulation of nephron tubule epithelial cell differentiation","Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation."]
["green",450,82,7,0.002665039,1,3,0.036585366,0.428571429,7,"GO:0055008","BP","cardiac muscle tissue morphogenesis","The process in which the anatomical structures of cardiac muscle tissue are generated and organized."]
["green",450,82,8,0.003304309,1,6,0.073170732,0.176470588,34,"GO:0003007","BP","heart morphogenesis","The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood."]
["green",450,82,9,0.004126792,1,3,0.036585366,0.375,8,"GO:0048644","BP","muscle organ morphogenesis","The process in which the anatomical structures of muscle are generated and organized."]
["green",450,82,10,0.005224086,1,7,0.085365854,0.142857143,49,"GO:0030155","BP","regulation of cell adhesion","Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix."]
["greenyellow",389,67,1,{"v":5.81e-05,"d":"5.81E-05"},0.364633928,5,0.074626866,0.384615385,13,"GO:0006814","BP","sodium ion transport","The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore."]
["greenyellow",389,67,2,{"v":6.77e-05,"d":"6.77E-05"},0.42492203,6,0.089552239,0.285714286,21,"GO:0006813","BP","potassium ion transport","The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore."]
["greenyellow",389,67,3,0.000442093,1,5,0.074626866,0.263157895,19,"GO:0071805","BP","potassium ion transmembrane transport","A process in which a potassium ion is transported from one side of a membrane to the other."]
["greenyellow",389,67,4,0.000867524,1,3,0.044776119,0.5,6,"GO:0015293","MF","symporter activity","Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]
["greenyellow",389,67,5,0.000915317,1,4,0.059701493,0.307692308,13,"GO:0034605","BP","cellular response to heat","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism."]
["greenyellow",389,67,6,0.000975942,1,6,0.089552239,0.181818182,33,"GO:0005840","CC","ribosome","An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins."]
["greenyellow",389,67,7,0.001032141,1,11,0.164179104,0.105769231,104,"GO:1990904","CC","ribonucleoprotein complex","A macromolecular complex containing both protein and RNA molecules."]
["greenyellow",389,67,8,1.080346E-3,1,34,0.507462687,0.057529611,591,"GO:0032991","CC","protein-containing complex","A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together."]
["greenyellow",389,67,9,1.321156E-3,1,2,0.029850746,1,2,"GO:0008273","MF","calcium, potassium:sodium antiporter activity","Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)."]
["greenyellow",389,67,10,1.652979E-3,1,4,0.059701493,0.266666667,15,"GO:0006605","BP","protein targeting","The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif."]
["grey",111,22,1,1.236699E-3,1,14,0.636363636,0.02513465,557,"GO:0048856","BP","anatomical structure development","The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome."]
["grey",111,22,2,0.001350343,1,2,0.090909091,0.4,5,"GO:0031076","BP","embryonic camera-type eye development","The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure."]
["grey",111,22,3,1.744703E-3,1,3,0.136363636,0.142857143,21,"GO:0042063","BP","gliogenesis","The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia."]
["grey",111,22,4,1.867683E-3,1,13,0.590909091,0.025641026,507,"GO:0007275","BP","multicellular organism development","The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)."]
["grey",111,22,5,0.002004454,1,3,0.136363636,0.136363636,22,"GO:0050768","BP","negative regulation of neurogenesis","Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system."]
["grey",111,22,6,2.155208E-3,1,4,0.181818182,0.083333333,48,"GO:0001654","BP","eye development","The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight."]
["grey",111,22,7,2.155208E-3,1,4,0.181818182,0.083333333,48,"GO:0048880","BP","sensory system development","The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure."]
["grey",111,22,8,0.002317477,1,14,0.636363636,0.023728814,590,"GO:0032502","BP","developmental process","A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition."]
["grey",111,22,9,0.002390666,1,6,0.272727273,0.049180328,122,"GO:0048646","BP","anatomical structure formation involved in morphogenesis","The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome."]
["grey",111,22,10,0.002403275,1,11,0.5,0.028423773,387,"GO:0030154","BP","cell differentiation","The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state."]
["grey60",281,37,1,0.0059017,1,3,0.081081081,0.157894737,19,"GO:0005096","MF","GTPase activator activity","Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP."]
["grey60",281,37,2,0.010318697,1,2,0.054054054,0.25,8,"GO:0006906","BP","vesicle fusion","Fusion of the membrane of a transport vesicle with its target membrane."]
["grey60",281,37,3,0.010774389,1,4,0.108108108,0.090909091,44,"GO:0005216","MF","ion channel activity","Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)."]
["grey60",281,37,4,0.012162053,1,6,0.162162162,0.06122449,98,"GO:0006518","BP","peptide metabolic process","The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another."]
["grey60",281,37,5,0.015645961,1,4,0.108108108,0.081632653,49,"GO:0015267","MF","channel activity","Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules."]
["grey60",281,37,6,0.016166297,1,2,0.054054054,0.2,10,"GO:0005267","MF","potassium channel activity","Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]
["grey60",281,37,7,0.019367695,1,3,0.081081081,0.103448276,29,"GO:0043547","BP","positive regulation of GTPase activity","Any process that activates or increases the activity of a GTPase."]
["grey60",281,37,8,0.019509085,1,2,0.054054054,0.181818182,11,"GO:0048489","BP","synaptic vesicle transport","The directed movement of synaptic vesicles."]
["grey60",281,37,9,0.020218579,1,1,0.027027027,1,1,"GO:0009157","BP","deoxyribonucleoside monophosphate biosynthetic process","The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar."]
["grey60",281,37,10,0.020218579,1,1,0.027027027,1,1,"GO:0009312","BP","oligosaccharide biosynthetic process","The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages."]
["lightcyan",310,46,1,0.001577423,1,3,0.065217391,0.3,10,"GO:0002685","BP","regulation of leukocyte migration","Any process that modulates the frequency, rate, or extent of leukocyte migration."]
["lightcyan",310,46,2,0.00359267,1,2,0.043478261,0.5,4,"GO:0031848","BP","protection from non-homologous end joining at telomere","A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse."]
["lightcyan",310,46,3,0.005892014,1,2,0.043478261,0.4,5,"GO:0016233","BP","telomere capping","A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins."]
["lightcyan",310,46,4,0.005892014,1,2,0.043478261,0.4,5,"GO:0043247","BP","telomere maintenance in response to DNA damage","Any process that occur in response to the presence of critically short or damaged telomeres."]
["lightcyan",310,46,5,0.005892014,1,2,0.043478261,0.4,5,"GO:0090148","BP","membrane fission","A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes."]
["lightcyan",310,46,6,0.008696899,1,2,0.043478261,0.333333333,6,"GO:0050921","BP","positive regulation of chemotaxis","Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient."]
["lightcyan",310,46,7,0.009313291,1,3,0.065217391,0.166666667,18,"GO:0050900","BP","leukocyte migration","The movement of a leukocyte within or between different tissues and organs of the body."]
["lightcyan",310,46,8,0.009817196,1,24,0.52173913,0.037914692,633,"GO:0003824","MF","catalytic activity","Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."]
["lightcyan",310,46,9,0.011981566,1,2,0.043478261,0.285714286,7,"GO:0007052","BP","mitotic spindle organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle."]
["lightcyan",310,46,10,0.013808287,1,4,0.086956522,0.105263158,38,"GO:0005635","CC","nuclear envelope","The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)."]
["lightcyan1",85,18,1,0.002705331,1,7,0.388888889,0.03286385,213,"GO:0005856","CC","cytoskeleton","Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles."]
["lightcyan1",85,18,2,3.6005E-3,1,4,0.222222222,0.058823529,68,"GO:0015629","CC","actin cytoskeleton","The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes."]
["lightcyan1",85,18,3,7.756298E-3,1,2,0.111111111,0.142857143,14,"GO:0016042","BP","lipid catabolic process","The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent."]
["lightcyan1",85,18,4,0.009836066,1,1,0.055555556,1,1,"GO:0006285","BP","base-excision repair, AP site formation","The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired."]
["lightcyan1",85,18,5,0.009836066,1,1,0.055555556,1,1,"GO:0006296","BP","nucleotide-excision repair, DNA incision, 5'-to lesion","The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage."]
["lightcyan1",85,18,6,0.009836066,1,1,0.055555556,1,1,"GO:0006574","BP","valine catabolic process","The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid."]
["lightcyan1",85,18,7,0.009836066,1,1,0.055555556,1,1,"GO:0031048","BP","chromatin silencing by small RNA","Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region."]
["lightcyan1",85,18,8,0.009836066,1,1,0.055555556,1,1,"GO:0032957","BP","inositol trisphosphate metabolic process","The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached."]
["lightcyan1",85,18,9,0.009836066,1,1,0.055555556,1,1,"GO:0052746","BP","inositol phosphorylation","The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms."]
["lightcyan1",85,18,10,0.009836066,1,1,0.055555556,1,1,"GO:1902570","BP","protein localization to nucleolus","NA"]
["lightgreen",280,50,1,1.84864E-4,1,3,0.06,0.6,5,"GO:0072332","BP","intrinsic apoptotic signaling pathway by p53 class mediator","A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered."]
["lightgreen",280,50,2,0.000288577,1,5,0.1,0.217391304,23,"GO:0008202","BP","steroid metabolic process","The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus."]
["lightgreen",280,50,3,0.000403932,1,4,0.08,0.285714286,14,"GO:0006694","BP","steroid biosynthetic process","The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification."]
["lightgreen",280,50,4,0.000731983,1,2,0.04,1,2,"GO:1902811","BP","positive regulation of skeletal muscle fiber differentiation","NA"]
["lightgreen",280,50,5,0.002157509,1,2,0.04,0.666666667,3,"GO:0033033","BP","negative regulation of myeloid cell apoptotic process","Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process."]
["lightgreen",280,50,6,0.002157509,1,2,0.04,0.666666667,3,"GO:0042771","BP","intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator","A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered."]
["lightgreen",280,50,7,2.798919E-3,1,5,0.1,0.135135135,37,"GO:0097190","BP","apoptotic signaling pathway","A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered."]
["lightgreen",280,50,8,0.002955536,1,9,0.18,0.078947368,114,"GO:0006974","BP","cellular response to DNA damage stimulus","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism."]
["lightgreen",280,50,9,0.003018278,1,8,0.16,0.086021505,93,"GO:0006629","BP","lipid metabolic process","The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids."]
["lightgreen",280,50,10,0.00423962,1,2,0.04,0.5,4,"GO:2001016","BP","positive regulation of skeletal muscle cell differentiation","Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation."]
["lightsteelblue1",104,14,1,0.00474033,1,3,0.214285714,0.063829787,47,"GO:0031966","CC","mitochondrial membrane","Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope."]
["lightsteelblue1",104,14,2,7.650273E-3,1,1,0.071428571,1,1,"GO:0003056","BP","regulation of vascular smooth muscle contraction","Any process that increases the frequency, rate or extent of vascular smooth muscle contraction."]
["lightsteelblue1",104,14,3,7.650273E-3,1,1,0.071428571,1,1,"GO:0006601","BP","creatine biosynthetic process","The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle."]
["lightsteelblue1",104,14,4,7.650273E-3,1,1,0.071428571,1,1,"GO:0007197","BP","adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway","The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)."]
["lightsteelblue1",104,14,5,7.650273E-3,1,1,0.071428571,1,1,"GO:0021895","BP","cerebral cortex neuron differentiation","The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex."]
["lightsteelblue1",104,14,6,7.650273E-3,1,1,0.071428571,1,1,"GO:0045987","BP","positive regulation of smooth muscle contraction","Any process that activates or increases the frequency, rate or extent of smooth muscle contraction."]
["lightsteelblue1",104,14,7,7.650273E-3,1,1,0.071428571,1,1,"GO:0046541","BP","saliva secretion","The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin."]
["lightsteelblue1",104,14,8,7.650273E-3,1,1,0.071428571,1,1,"GO:0097345","BP","mitochondrial outer membrane permeabilization","The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway."]
["lightsteelblue1",104,14,9,7.650273E-3,1,1,0.071428571,1,1,"GO:0098664","BP","G protein-coupled serotonin receptor signaling pathway","The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands."]
["lightsteelblue1",104,14,10,7.650273E-3,1,1,0.071428571,1,1,"GO:0005940","CC","septin ring","A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form."]
["lightyellow",253,36,1,0.001036062,1,3,0.083333333,0.272727273,11,"GO:0006937","BP","regulation of muscle contraction","Any process that modulates the frequency, rate or extent of muscle contraction."]
["lightyellow",253,36,2,0.003626339,1,2,0.055555556,0.4,5,"GO:0003009","BP","skeletal muscle contraction","A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control."]
["lightyellow",253,36,3,0.003626339,1,2,0.055555556,0.4,5,"GO:0005861","CC","troponin complex","A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction."]
["lightyellow",253,36,4,0.006963069,1,4,0.111111111,0.1,40,"GO:0030017","CC","sarcomere","The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs."]
["lightyellow",253,36,5,0.008330999,1,3,0.083333333,0.136363636,22,"GO:0006936","BP","muscle contraction","A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis."]
["lightyellow",253,36,6,0.00978243,1,2,0.055555556,0.25,8,"GO:0035914","BP","skeletal muscle cell differentiation","The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle."]
["lightyellow",253,36,7,0.00978243,1,2,0.055555556,0.25,8,"GO:0032182","MF","ubiquitin-like protein binding","Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein."]
["lightyellow",253,36,8,0.013253332,1,4,0.111111111,0.083333333,48,"GO:0034097","BP","response to cytokine","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus."]
["lightyellow",253,36,9,0.013253332,1,4,0.111111111,0.083333333,48,"GO:0030016","CC","myofibril","The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism."]
["lightyellow",253,36,10,0.015253455,1,4,0.111111111,0.08,50,"GO:0043292","CC","contractile fiber","Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle."]
["magenta",312,42,1,0.000581621,1,3,0.071428571,0.375,8,"GO:0001541","BP","ovarian follicle development","The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure."]
["magenta",312,42,2,0.000639877,1,12,0.285714286,0.064171123,187,"GO:0007049","BP","cell cycle","The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division."]
["magenta",312,42,3,0.001206886,1,3,0.071428571,0.3,10,"GO:0000079","BP","regulation of cyclin-dependent protein serine/threonine kinase activity","Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity."]
["magenta",312,42,4,0.002997538,1,2,0.047619048,0.5,4,"GO:0043279","BP","response to alkaloid","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active."]
["magenta",312,42,5,3.433293E-3,1,3,0.071428571,0.214285714,14,"GO:0008585","BP","female gonad development","The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure."]
["magenta",312,42,6,0.004223421,1,3,0.071428571,0.2,15,"GO:0030336","BP","negative regulation of cell migration","Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration."]
["magenta",312,42,7,4.923228E-3,1,2,0.047619048,0.4,5,"GO:0010831","BP","positive regulation of myotube differentiation","Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse."]
["magenta",312,42,8,4.923228E-3,1,2,0.047619048,0.4,5,"GO:0045663","BP","positive regulation of myoblast differentiation","Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers."]
["magenta",312,42,9,0.005850958,1,7,0.166666667,0.071428571,98,"GO:0051726","BP","regulation of cell cycle","Any process that modulates the rate or extent of progression through the cell cycle."]
["magenta",312,42,10,0.006055128,1,4,0.095238095,0.121212121,33,"GO:0048545","BP","response to steroid hormone","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus."]
["mediumpurple3",114,22,1,0.009935507,1,2,0.090909091,0.153846154,13,"GO:0003418","BP","growth plate cartilage chondrocyte differentiation","The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage."]
["mediumpurple3",114,22,2,0.012021858,1,1,0.045454545,1,1,"GO:0000244","BP","spliceosomal tri-snRNP complex assembly","The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex."]
["mediumpurple3",114,22,3,0.012021858,1,1,0.045454545,1,1,"GO:0000727","BP","double-strand break repair via break-induced replication","The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome."]
["mediumpurple3",114,22,4,0.012021858,1,1,0.045454545,1,1,"GO:0001778","BP","plasma membrane repair","The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress."]
["mediumpurple3",114,22,5,0.012021858,1,1,0.045454545,1,1,"GO:0001951","BP","intestinal D-glucose absorption","Uptake of D-glucose into the blood by absorption from the small intestine."]
["mediumpurple3",114,22,6,0.012021858,1,1,0.045454545,1,1,"GO:0006267","BP","pre-replicative complex assembly involved in nuclear cell cycle DNA replication","The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation."]
["mediumpurple3",114,22,7,0.012021858,1,1,0.045454545,1,1,"GO:0032532","BP","regulation of microvillus length","A process that modulates the length of a microvillus."]
["mediumpurple3",114,22,8,0.012021858,1,1,0.045454545,1,1,"GO:0035235","BP","ionotropic glutamate receptor signaling pathway","A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription."]
["mediumpurple3",114,22,9,0.012021858,1,1,0.045454545,1,1,"GO:0042840","BP","D-glucuronate catabolic process","The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate."]
["mediumpurple3",114,22,10,0.012021858,1,1,0.045454545,1,1,"GO:0043616","BP","keratinocyte proliferation","The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin."]
["midnightblue",314,56,1,{"v":8.85e-05,"d":"8.85E-05"},0.555318271,14,0.25,0.093959732,149,"GO:0007010","BP","cytoskeleton organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures."]
["midnightblue",314,56,2,0.000895463,1,11,0.196428571,0.089430894,123,"GO:0008092","MF","cytoskeletal protein binding","Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)."]
["midnightblue",314,56,3,0.000902546,1,9,0.160714286,0.104651163,86,"GO:0030036","BP","actin cytoskeleton organization","A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins."]
["midnightblue",314,56,4,1.84209E-3,1,10,0.178571429,0.087719298,114,"GO:0099512","CC","supramolecular fiber","A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure."]
["midnightblue",314,56,5,0.002166096,1,4,0.071428571,0.210526316,19,"GO:0005884","CC","actin filament","A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane."]
["midnightblue",314,56,6,0.002279927,1,7,0.125,0.112903226,62,"GO:0003779","MF","actin binding","Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments."]
["midnightblue",314,56,7,0.002706257,1,2,0.035714286,0.666666667,3,"GO:0002327","BP","immature B cell differentiation","The process in which a precursor cell type acquires the specialized features of an immature B cell."]
["midnightblue",314,56,8,0.003895077,1,7,0.125,0.102941176,68,"GO:0015629","CC","actin cytoskeleton","The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes."]
["midnightblue",314,56,9,0.004089678,1,5,0.089285714,0.138888889,36,"GO:0051015","MF","actin filament binding","Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits."]
["midnightblue",314,56,10,0.004516788,1,4,0.071428571,0.173913043,23,"GO:0008017","MF","microtubule binding","Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers."]
["orange",168,25,1,1.79261E-4,1,2,0.08,1,2,"GO:0045263","CC","proton-transporting ATP synthase complex, coupling factor F(o)","All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins."]
["orange",168,25,2,0.000533273,1,2,0.08,0.666666667,3,"GO:0015986","BP","ATP synthesis coupled proton transport","The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis."]
["orange",168,25,3,0.000533273,1,2,0.08,0.666666667,3,"GO:0005753","CC","mitochondrial proton-transporting ATP synthase complex","A proton-transporting ATP synthase complex found in the mitochondrial membrane."]
["orange",168,25,4,0.000533273,1,2,0.08,0.666666667,3,"GO:0045259","CC","proton-transporting ATP synthase complex","A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient."]
["orange",168,25,5,1.747909E-3,1,2,0.08,0.4,5,"GO:0032436","BP","positive regulation of proteasomal ubiquitin-dependent protein catabolic process","Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome."]
["orange",168,25,6,1.890634E-3,1,3,0.12,0.157894737,19,"GO:0045862","BP","positive regulation of proteolysis","Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein."]
["orange",168,25,7,2.599915E-3,1,2,0.08,0.333333333,6,"GO:1901800","BP","positive regulation of proteasomal protein catabolic process","NA"]
["orange",168,25,8,0.003609429,1,2,0.08,0.285714286,7,"GO:0032434","BP","regulation of proteasomal ubiquitin-dependent protein catabolic process","Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome."]
["orange",168,25,9,3.77452E-3,1,3,0.12,0.125,24,"GO:0046777","BP","protein autophosphorylation","The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)."]
["orange",168,25,10,0.004772336,1,2,0.08,0.25,8,"GO:0038083","BP","peptidyl-tyrosine autophosphorylation","The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein."]
["orangered4",110,21,1,0.002659335,1,6,0.285714286,0.045801527,131,"GO:0046907","BP","intracellular transport","The directed movement of substances within a cell."]
["orangered4",110,21,2,0.003471987,1,10,0.476190476,0.027700831,361,"GO:0006810","BP","transport","The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein."]
["orangered4",110,21,3,0.01147541,1,1,0.047619048,1,1,"GO:0015670","BP","carbon dioxide transport","The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore."]
["orangered4",110,21,4,0.01147541,1,1,0.047619048,1,1,"GO:0015786","BP","UDP-glucose transmembrane transport","The process in which UDP-glucose is transported across a membrane."]
["orangered4",110,21,5,0.01147541,1,1,0.047619048,1,1,"GO:0030242","BP","autophagy of peroxisome","The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions."]
["orangered4",110,21,6,0.01147541,1,1,0.047619048,1,1,"GO:0032230","BP","positive regulation of synaptic transmission, GABAergic","Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)."]
["orangered4",110,21,7,0.01147541,1,1,0.047619048,1,1,"GO:0032849","BP","positive regulation of cellular pH reduction","Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell."]
["orangered4",110,21,8,0.01147541,1,1,0.047619048,1,1,"GO:0036494","BP","positive regulation of translation initiation in response to endoplasmic reticulum stress","Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress."]
["orangered4",110,21,9,0.01147541,1,1,0.047619048,1,1,"GO:0050973","BP","detection of mechanical stimulus involved in equilibrioception","The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears."]
["orangered4",110,21,10,0.01147541,1,1,0.047619048,1,1,"GO:0060013","BP","righting reflex","A reflex process in which an animal immediately tries to turn over after being placed in a supine position."]
["paleturquoise",161,20,1,0.000672281,1,2,0.1,0.5,4,"GO:0007157","BP","heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules","The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell."]
["paleturquoise",161,20,2,0.003210356,1,4,0.2,0.06779661,59,"GO:0030424","CC","axon","The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter."]
["paleturquoise",161,20,3,0.00340525,1,3,0.15,0.103448276,29,"GO:0051260","BP","protein homooligomerization","The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer."]
["paleturquoise",161,20,4,0.007382222,1,3,0.15,0.078947368,38,"GO:0051259","BP","protein complex oligomerization","The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer."]
["paleturquoise",161,20,5,0.0082379,1,2,0.1,0.153846154,13,"GO:0021510","BP","spinal cord development","The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues."]
["paleturquoise",161,20,6,0.008645695,1,5,0.25,0.040650407,123,"GO:0043005","CC","neuron projection","A prolongation or process extending from a nerve cell, e.g. an axon or dendrite."]
["paleturquoise",161,20,7,0.010928962,1,1,0.05,1,1,"GO:0002138","BP","retinoic acid biosynthetic process","The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A."]
["paleturquoise",161,20,8,0.010928962,1,1,0.05,1,1,"GO:0009435","BP","NAD biosynthetic process","The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH."]
["paleturquoise",161,20,9,0.010928962,1,1,0.05,1,1,"GO:0016056","BP","rhodopsin mediated signaling pathway","The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response."]
["paleturquoise",161,20,10,0.010928962,1,1,0.05,1,1,"GO:0019896","BP","axonal transport of mitochondrion","The directed movement of mitochondria along microtubules in nerve cell axons."]
["pink",484,75,1,0.000469818,1,39,0.52,0.064144737,608,"GO:0009058","BP","biosynthetic process","The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones."]
["pink",484,75,2,1.21054E-3,1,3,0.04,0.5,6,"GO:0006367","BP","transcription initiation from RNA polymerase II promoter","Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription."]
["pink",484,75,3,0.001658167,1,2,0.026666667,1,2,"GO:0045943","BP","positive regulation of transcription by RNA polymerase I","Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I."]
["pink",484,75,4,0.001658167,1,2,0.026666667,1,2,"GO:0051123","BP","RNA polymerase II preinitiation complex assembly","The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase."]
["pink",484,75,5,0.001658167,1,2,0.026666667,1,2,"GO:0000124","CC","SAGA complex","A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8."]
["pink",484,75,6,0.001658167,1,2,0.026666667,1,2,"GO:0005671","CC","Ada2/Gcn5/Ada3 transcription activator complex","A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues."]
["pink",484,75,7,0.002831383,1,6,0.08,0.166666667,36,"GO:0016829","MF","lyase activity","Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring."]
["pink",484,75,8,0.002903101,1,31,0.413333333,0.064182195,483,"GO:0034645","BP","cellular macromolecule biosynthetic process","The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells."]
["pink",484,75,9,0.003492511,1,27,0.36,0.066831683,404,"GO:0019438","BP","aromatic compound biosynthetic process","The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring."]
["pink",484,75,10,0.004649398,1,3,0.04,0.333333333,9,"GO:0006487","BP","protein N-linked glycosylation","A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan."]
["plum1",132,14,1,0.000536652,1,2,0.142857143,0.4,5,"GO:0043407","BP","negative regulation of MAP kinase activity","Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity."]
["plum1",132,14,2,1.898371E-3,1,2,0.142857143,0.222222222,9,"GO:0071901","BP","negative regulation of protein serine/threonine kinase activity","Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity."]
["plum1",132,14,3,0.006924725,1,2,0.142857143,0.117647059,17,"GO:0006469","BP","negative regulation of protein kinase activity","Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity."]
["plum1",132,14,4,7.650273E-3,1,1,0.071428571,1,1,"GO:0015878","BP","biotin transport","The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions."]
["plum1",132,14,5,7.650273E-3,1,1,0.071428571,1,1,"GO:0004473","MF","malate dehydrogenase (decarboxylating) (NADP+) activity","Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+."]
["plum1",132,14,6,7.650273E-3,1,1,0.071428571,1,1,"GO:0008948","MF","oxaloacetate decarboxylase activity","Catalysis of the reaction: oxaloacetate = pyruvate + CO2."]
["plum1",132,14,7,7.756298E-3,1,2,0.142857143,0.111111111,18,"GO:0033673","BP","negative regulation of kinase activity","Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule."]
["plum1",132,14,8,0.011507365,1,2,0.142857143,0.090909091,22,"GO:0004721","MF","phosphoprotein phosphatase activity","Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity."]
["plum1",132,14,9,0.012785299,1,3,0.214285714,0.044776119,67,"GO:0045859","BP","regulation of protein kinase activity","Any process that modulates the frequency, rate or extent of protein kinase activity."]
["plum1",132,14,10,0.014978304,1,3,0.214285714,0.042253521,71,"GO:0043549","BP","regulation of kinase activity","Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule."]
["purple",368,62,1,0.000689219,1,3,0.048387097,0.5,6,"GO:0071347","BP","cellular response to interleukin-1","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus."]
["purple",368,62,2,0.001129944,1,2,0.032258065,1,2,"GO:0030916","BP","otic vesicle formation","The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear."]
["purple",368,62,3,0.002690434,1,3,0.048387097,0.333333333,9,"GO:0061036","BP","positive regulation of cartilage development","Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate."]
["purple",368,62,4,0.002690434,1,3,0.048387097,0.333333333,9,"GO:0070555","BP","response to interleukin-1","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus."]
["purple",368,62,5,0.003315655,1,2,0.032258065,0.666666667,3,"GO:0071599","BP","otic vesicle development","The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear."]
["purple",368,62,6,0.004638906,1,4,0.064516129,0.19047619,21,"GO:0071772","BP","response to BMP","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus."]
["purple",368,62,7,0.004638906,1,4,0.064516129,0.19047619,21,"GO:0071773","BP","cellular response to BMP stimulus","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus."]
["purple",368,62,8,0.010575491,1,2,0.032258065,0.4,5,"GO:0032332","BP","positive regulation of chondrocyte differentiation","Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation."]
["purple",368,62,9,0.010575491,1,2,0.032258065,0.4,5,"GO:0005637","CC","nuclear inner membrane","The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope."]
["purple",368,62,10,0.015137651,1,3,0.048387097,0.1875,16,"GO:0017016","MF","Ras GTPase binding","Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases."]
["red",512,95,1,0.000522437,1,3,0.031578947,0.75,4,"GO:0032275","BP","luteinizing hormone secretion","The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary."]
["red",512,95,2,0.000822565,1,6,0.063157895,0.260869565,23,"GO:0009142","BP","nucleoside triphosphate biosynthetic process","The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar."]
["red",512,95,3,0.001256873,1,3,0.031578947,0.6,5,"GO:0045662","BP","negative regulation of myoblast differentiation","Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers."]
["red",512,95,4,0.001695947,1,5,0.052631579,0.277777778,18,"GO:0006754","BP","ATP biosynthetic process","The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator."]
["red",512,95,5,0.002668005,1,2,0.021052632,1,2,"GO:0032385","BP","positive regulation of intracellular cholesterol transport","Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells."]
["red",512,95,6,0.00427919,1,7,0.073684211,0.170731707,41,"GO:0009165","BP","nucleotide biosynthetic process","The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)."]
["red",512,95,7,0.007662661,1,4,0.042105263,0.25,16,"GO:0016032","BP","viral process","A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle."]
["red",512,95,8,7.732544E-3,1,2,0.021052632,0.666666667,3,"GO:0032367","BP","intracellular cholesterol transport","The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells."]
["red",512,95,9,7.732544E-3,1,2,0.021052632,0.666666667,3,"GO:0032374","BP","regulation of cholesterol transport","Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore."]
["red",512,95,10,7.732544E-3,1,2,0.021052632,0.666666667,3,"GO:0032801","BP","receptor catabolic process","The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function."]
["royalblue",283,49,1,2.56062E-3,1,3,0.06122449,0.272727273,11,"GO:0007224","BP","smoothened signaling pathway","A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened."]
["royalblue",283,49,2,0.006672473,1,2,0.040816327,0.4,5,"GO:0008589","BP","regulation of smoothened signaling pathway","Any process that modulates the frequency, rate or extent of smoothened signaling."]
["royalblue",283,49,3,0.006672473,1,2,0.040816327,0.4,5,"GO:0045880","BP","positive regulation of smoothened signaling pathway","Any process that activates or increases the frequency, rate or extent of smoothened signaling."]
["royalblue",283,49,4,0.007907185,1,3,0.06122449,0.1875,16,"GO:0048704","BP","embryonic skeletal system morphogenesis","The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase."]
["royalblue",283,49,5,0.012931097,1,3,0.06122449,0.157894737,19,"GO:0048706","BP","embryonic skeletal system development","The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure."]
["royalblue",283,49,6,0.013538906,1,2,0.040816327,0.285714286,7,"GO:0031103","BP","axon regeneration","The regrowth of axons following their loss or damage."]
["royalblue",283,49,7,0.017745229,1,2,0.040816327,0.25,8,"GO:0006493","BP","protein O-linked glycosylation","A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan."]
["royalblue",283,49,8,0.017745229,1,2,0.040816327,0.25,8,"GO:0018126","BP","protein hydroxylation","The addition of a hydroxy group to a protein amino acid."]
["royalblue",283,49,9,0.02242845,1,2,0.040816327,0.222222222,9,"GO:0048678","BP","response to axon injury","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus."]
["royalblue",283,49,10,0.026775956,1,1,0.020408163,1,1,"GO:0000738","BP","DNA catabolic process, exonucleolytic","The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides."]
["saddlebrown",170,17,1,9.289617E-3,1,1,0.058823529,1,1,"GO:0006069","BP","ethanol oxidation","An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate."]
["saddlebrown",170,17,2,9.289617E-3,1,1,0.058823529,1,1,"GO:0006527","BP","arginine catabolic process","The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid."]
["saddlebrown",170,17,3,9.289617E-3,1,1,0.058823529,1,1,"GO:0007263","BP","nitric oxide mediated signal transduction","Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms."]
["saddlebrown",170,17,4,9.289617E-3,1,1,0.058823529,1,1,"GO:0019284","BP","L-methionine salvage from S-adenosylmethionine","The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine."]
["saddlebrown",170,17,5,9.289617E-3,1,1,0.058823529,1,1,"GO:0030854","BP","positive regulation of granulocyte differentiation","Any process that activates or increases the frequency, rate or extent of granulocyte differentiation."]
["saddlebrown",170,17,6,9.289617E-3,1,1,0.058823529,1,1,"GO:0045776","BP","negative regulation of blood pressure","Any process in which the force of blood traveling through the circulatory system is decreased."]
["saddlebrown",170,17,7,9.289617E-3,1,1,0.058823529,1,1,"GO:0048392","BP","intermediate mesodermal cell differentiation","The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell."]
["saddlebrown",170,17,8,9.289617E-3,1,1,0.058823529,1,1,"GO:0060684","BP","epithelial-mesenchymal cell signaling","Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted."]
["saddlebrown",170,17,9,9.289617E-3,1,1,0.058823529,1,1,"GO:0072138","BP","mesenchymal cell proliferation involved in ureteric bud development","The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development."]
["saddlebrown",170,17,10,9.289617E-3,1,1,0.058823529,1,1,"GO:0072198","BP","mesenchymal cell proliferation involved in ureter development","The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development."]
["salmon",360,50,1,0.000731983,1,2,0.04,1,2,"GO:0000395","BP","mRNA 5'-splice site recognition","Recognition of the intron 5'-splice site by components of the assembling spliceosome."]
["salmon",360,50,2,0.002157509,1,2,0.04,0.666666667,3,"GO:0001676","BP","long-chain fatty acid metabolic process","The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22."]
["salmon",360,50,3,0.002157509,1,2,0.04,0.666666667,3,"GO:0010693","BP","negative regulation of alkaline phosphatase activity","Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum."]
["salmon",360,50,4,0.003550702,1,3,0.06,0.25,12,"GO:0005684","CC","U2-type spliceosomal complex","Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends."]
["salmon",360,50,5,0.00423962,1,2,0.04,0.5,4,"GO:0035869","CC","ciliary transition zone","A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm."]
["salmon",360,50,6,0.00694279,1,2,0.04,0.4,5,"GO:0006376","BP","mRNA splice site selection","Selection of a splice site by components of the assembling spliceosome."]
["salmon",360,50,7,0.008366884,1,3,0.06,0.1875,16,"GO:0000723","BP","telomere maintenance","Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences."]
["salmon",360,50,8,0.008366884,1,3,0.06,0.1875,16,"GO:0048704","BP","embryonic skeletal system morphogenesis","The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase."]
["salmon",360,50,9,0.010232883,1,2,0.04,0.333333333,6,"GO:0000245","BP","spliceosomal complex assembly","The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions."]
["salmon",360,50,10,0.010232883,1,2,0.04,0.333333333,6,"GO:0071466","BP","cellular response to xenobiotic stimulus","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms."]
["sienna3",142,25,1,2.924304E-3,1,3,0.12,0.136363636,22,"GO:0009755","BP","hormone-mediated signaling pathway","A series of molecular signals mediated by the detection of a hormone."]
["sienna3",142,25,2,0.003173806,1,5,0.2,0.064935065,77,"GO:0009725","BP","response to hormone","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus."]
["sienna3",142,25,3,0.004761869,1,3,0.12,0.115384615,26,"GO:0007548","BP","sex differentiation","The establishment of the sex of an organism by physical differentiation."]
["sienna3",142,25,4,0.004772336,1,2,0.08,0.25,8,"GO:0050796","BP","regulation of insulin secretion","Any process that modulates the frequency, rate or extent of the regulated release of insulin."]
["sienna3",142,25,5,0.00610318,1,6,0.24,0.046875,128,"GO:0007155","BP","cell adhesion","The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules."]
["sienna3",142,25,6,0.006165156,1,4,0.16,0.071428571,56,"GO:0032870","BP","cellular response to hormone stimulus","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus."]
["sienna3",142,25,7,0.012748925,1,2,0.08,0.153846154,13,"GO:0030073","BP","insulin secretion","The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin."]
["sienna3",142,25,8,0.012748925,1,2,0.08,0.153846154,13,"GO:0046887","BP","positive regulation of hormone secretion","Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell."]
["sienna3",142,25,9,0.013661202,1,1,0.04,1,1,"GO:0001692","BP","histamine metabolic process","The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans."]
["sienna3",142,25,10,0.013661202,1,1,0.04,1,1,"GO:0002315","BP","marginal zone B cell differentiation","The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)."]
["skyblue",188,35,1,0.0020822,1,2,0.057142857,0.5,4,"GO:0006336","BP","DNA replication-independent nucleosome assembly","The formation of nucleosomes outside the context of DNA replication."]
["skyblue",188,35,2,2.375421E-3,1,5,0.142857143,0.098039216,51,"GO:0051345","BP","positive regulation of hydrolase activity","Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds."]
["skyblue",188,35,3,0.005037154,1,3,0.085714286,0.157894737,19,"GO:0001649","BP","osteoblast differentiation","The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone."]
["skyblue",188,35,4,5.081304E-3,1,2,0.057142857,0.333333333,6,"GO:1990090","BP","cellular response to nerve growth factor stimulus","A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus."]
["skyblue",188,35,5,0.009259311,1,2,0.057142857,0.25,8,"GO:0001938","BP","positive regulation of endothelial cell proliferation","Any process that activates or increases the rate or extent of endothelial cell proliferation."]
["skyblue",188,35,6,0.009853975,1,3,0.085714286,0.125,24,"GO:0043025","CC","neuronal cell body","The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites."]
["skyblue",188,35,7,0.010200308,1,6,0.171428571,0.06,100,"GO:0043085","BP","positive regulation of catalytic activity","Any process that activates or increases the activity of an enzyme."]
["skyblue",188,35,8,0.011052128,1,3,0.085714286,0.12,25,"GO:0070372","BP","regulation of ERK1 and ERK2 cascade","Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade."]
["skyblue",188,35,9,0.012331379,1,3,0.085714286,0.115384615,26,"GO:0070371","BP","ERK1 and ERK2 cascade","An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell."]
["skyblue",188,35,10,0.014527608,1,2,0.057142857,0.2,10,"GO:0045669","BP","positive regulation of osteoblast differentiation","Any process that activates or increases the frequency, rate or extent of osteoblast differentiation."]
["skyblue3",103,19,1,0.00744392,1,2,0.105263158,0.153846154,13,"GO:0042470","CC","melanosome","A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells."]
["skyblue3",103,19,2,0.009897336,1,2,0.105263158,0.133333333,15,"GO:0005788","CC","endoplasmic reticulum lumen","The volume enclosed by the membranes of the endoplasmic reticulum."]
["skyblue3",103,19,3,0.010382514,1,1,0.052631579,1,1,"GO:0006930","BP","substrate-dependent cell migration, cell extension","The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell."]
["skyblue3",103,19,4,0.010382514,1,1,0.052631579,1,1,"GO:0010452","BP","histone H3-K36 methylation","The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone."]
["skyblue3",103,19,5,0.010382514,1,1,0.052631579,1,1,"GO:0018021","BP","peptidyl-histidine methylation","The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)."]
["skyblue3",103,19,6,0.010382514,1,1,0.052631579,1,1,"GO:0018027","BP","peptidyl-lysine dimethylation","The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine."]
["skyblue3",103,19,7,0.010382514,1,1,0.052631579,1,1,"GO:0030047","BP","actin modification","Covalent modification of an actin molecule."]
["skyblue3",103,19,8,0.010382514,1,1,0.052631579,1,1,"GO:0030520","BP","intracellular estrogen receptor signaling pathway","Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription)."]
["skyblue3",103,19,9,0.010382514,1,1,0.052631579,1,1,"GO:0033026","BP","negative regulation of mast cell apoptotic process","Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process."]
["skyblue3",103,19,10,0.010382514,1,1,0.052631579,1,1,"GO:0045636","BP","positive regulation of melanocyte differentiation","Any process that activates or increases the frequency, rate or extent of melanocyte differentiation."]
["steelblue",169,22,1,0.003698995,1,2,0.090909091,0.25,8,"GO:0016529","CC","sarcoplasmic reticulum","A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage."]
["steelblue",169,22,2,0.00472127,1,2,0.090909091,0.222222222,9,"GO:0016528","CC","sarcoplasm","The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum."]
["steelblue",169,22,3,0.011962515,1,3,0.136363636,0.073170732,41,"GO:0043010","BP","camera-type eye development","The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field."]
["steelblue",169,22,4,0.012021858,1,1,0.045454545,1,1,"GO:0007468","BP","regulation of rhodopsin gene expression","Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation."]
["steelblue",169,22,5,0.012021858,1,1,0.045454545,1,1,"GO:0021670","BP","lateral ventricle development","The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle."]
["steelblue",169,22,6,0.012021858,1,1,0.045454545,1,1,"GO:0031274","BP","positive regulation of pseudopodium assembly","Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia."]
["steelblue",169,22,7,0.012021858,1,1,0.045454545,1,1,"GO:0045198","BP","establishment of epithelial cell apical/basal polarity","The specification and formation of the apicobasal polarity of an epithelial cell."]
["steelblue",169,22,8,0.012021858,1,1,0.045454545,1,1,"GO:0051988","BP","regulation of attachment of spindle microtubules to kinetochore","Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore."]
["steelblue",169,22,9,0.012021858,1,1,0.045454545,1,1,"GO:0061073","BP","ciliary body morphogenesis","The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes."]
["steelblue",169,22,10,0.012021858,1,1,0.045454545,1,1,"GO:1901827","BP","zeaxanthin biosynthetic process","NA"]
["tan",357,62,1,0.006486551,1,2,0.032258065,0.5,4,"GO:0007413","BP","axonal fasciculation","The collection of axons into a bundle of rods, known as a fascicle."]
["tan",357,62,2,0.006550979,1,3,0.048387097,0.25,12,"GO:0048813","BP","dendrite morphogenesis","The process in which the anatomical structures of a dendrite are generated and organized."]
["tan",357,62,3,0.008312365,1,3,0.048387097,0.230769231,13,"GO:0035335","BP","peptidyl-tyrosine dephosphorylation","The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine."]
["tan",357,62,4,0.008312365,1,3,0.048387097,0.230769231,13,"GO:0004725","MF","protein tyrosine phosphatase activity","Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate."]
["tan",357,62,5,0.01259979,1,3,0.048387097,0.2,15,"GO:0050807","BP","regulation of synapse organization","Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)."]
["tan",357,62,6,0.01259979,1,3,0.048387097,0.2,15,"GO:0005788","CC","endoplasmic reticulum lumen","The volume enclosed by the membranes of the endoplasmic reticulum."]
["tan",357,62,7,0.012642234,1,10,0.161290323,0.074626866,134,"GO:0046983","MF","protein dimerization activity","The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits."]
["tan",357,62,8,0.015029226,1,4,0.064516129,0.137931034,29,"GO:0016791","MF","phosphatase activity","Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate."]
["tan",357,62,9,0.015518627,1,2,0.032258065,0.333333333,6,"GO:0043966","BP","histone H3 acetylation","The modification of histone H3 by the addition of an acetyl group."]
["tan",357,62,10,0.015518627,1,2,0.032258065,0.333333333,6,"GO:0061098","BP","positive regulation of protein tyrosine kinase activity","Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity."]
["turquoise",638,103,1,1.73427E-4,1,3,0.029126214,1,3,"GO:0055091","BP","phospholipid homeostasis","Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell."]
["turquoise",638,103,2,0.000665232,1,3,0.029126214,0.75,4,"GO:0015485","MF","cholesterol binding","Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones."]
["turquoise",638,103,3,0.000746963,1,6,0.058252427,0.285714286,21,"GO:0006006","BP","glucose metabolic process","The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides."]
["turquoise",638,103,4,1.594975E-3,1,3,0.029126214,0.6,5,"GO:0097433","CC","dense body","An electron dense body which may contain granules."]
["turquoise",638,103,5,0.002299852,1,4,0.038834951,0.363636364,11,"GO:0005496","MF","steroid binding","Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene."]
["turquoise",638,103,6,0.003059639,1,3,0.029126214,0.5,6,"GO:0005319","MF","lipid transporter activity","Enables the directed movement of lipids into, out of or within a cell, or between cells."]
["turquoise",638,103,7,0.003138865,1,2,0.019417476,1,2,"GO:0002323","BP","natural killer cell activation involved in immune response","The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response."]
["turquoise",638,103,8,0.003138865,1,2,0.019417476,1,2,"GO:0043691","BP","reverse cholesterol transport","The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism."]
["turquoise",638,103,9,0.003138865,1,2,0.019417476,1,2,"GO:0034364","CC","high-density lipoprotein particle","A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process."]
["turquoise",638,103,10,0.003138865,1,2,0.019417476,1,2,"GO:0098973","MF","structural constituent of postsynaptic actin cytoskeleton","The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton."]
["violet",154,21,1,0.001830649,1,2,0.095238095,0.333333333,6,"GO:0010332","BP","response to gamma radiation","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum."]
["violet",154,21,2,0.001830649,1,2,0.095238095,0.333333333,6,"GO:0071480","BP","cellular response to gamma radiation","Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum."]
["violet",154,21,3,0.002545122,1,11,0.523809524,0.026699029,412,"GO:0010468","BP","regulation of gene expression","Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form."]
["violet",154,21,4,0.004588326,1,12,0.571428571,0.023391813,513,"GO:0010467","BP","gene expression","The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form."]
["violet",154,21,5,6.667465E-3,1,9,0.428571429,0.027439024,328,"GO:0006355","BP","regulation of transcription, DNA-templated","Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription."]
["violet",154,21,6,0.007244229,1,9,0.428571429,0.027108434,332,"GO:1903506","BP","regulation of nucleic acid-templated transcription","NA"]
["violet",154,21,7,0.007244229,1,9,0.428571429,0.027108434,332,"GO:2001141","BP","regulation of RNA biosynthetic process","Any process that modulates the frequency, rate or extent of RNA biosynthetic process."]
["violet",154,21,8,0.007702281,1,9,0.428571429,0.026865672,335,"GO:0006351","BP","transcription, DNA-templated","The cellular synthesis of RNA on a template of DNA."]
["violet",154,21,9,0.010492975,1,3,0.142857143,0.073170732,41,"GO:0043254","BP","regulation of protein complex assembly","Any process that modulates the frequency, rate or extent of protein complex assembly."]
["violet",154,21,10,0.01147541,1,1,0.047619048,1,1,"GO:0006294","BP","nucleotide-excision repair, preincision complex assembly","The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage."]
["white",186,23,1,0.000450058,1,2,0.086956522,0.666666667,3,"GO:0006526","BP","arginine biosynthetic process","The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid."]
["white",186,23,2,0.00147732,1,2,0.086956522,0.4,5,"GO:0006525","BP","arginine metabolic process","The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid."]
["white",186,23,3,2.199037E-3,1,2,0.086956522,0.333333333,6,"GO:0045599","BP","negative regulation of fat cell differentiation","Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation."]
["white",186,23,4,0.003055127,1,2,0.086956522,0.285714286,7,"GO:0030513","BP","positive regulation of BMP signaling pathway","Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity."]
["white",186,23,5,0.003055127,1,2,0.086956522,0.285714286,7,"GO:0072350","BP","tricarboxylic acid metabolic process","The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)."]
["white",186,23,6,0.004042392,1,2,0.086956522,0.25,8,"GO:0071013","CC","catalytic step 2 spliceosome","A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs."]
["white",186,23,7,0.005646118,1,3,0.130434783,0.1,30,"GO:0005743","CC","mitochondrial inner membrane","The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae."]
["white",186,23,8,0.006397933,1,2,0.086956522,0.2,10,"GO:0009060","BP","aerobic respiration","The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor."]
["white",186,23,9,0.007760079,1,2,0.086956522,0.181818182,11,"GO:0045444","BP","fat cell differentiation","The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat."]
["white",186,23,10,0.007760079,1,2,0.086956522,0.181818182,11,"GO:0070469","CC","respiratory chain","The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient."]
["yellow",655,97,1,0.002570409,1,3,0.030927835,0.5,6,"GO:0097194","BP","execution phase of apoptosis","A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died."]
["yellow",655,97,2,0.002782135,1,2,0.020618557,1,2,"GO:0018345","BP","protein palmitoylation","The covalent attachment of a palmitoyl group to a protein."]
["yellow",655,97,3,0.003998898,1,6,0.06185567,0.2,30,"GO:0043434","BP","response to peptide hormone","Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals."]
["yellow",655,97,4,4.325822E-3,1,3,0.030927835,0.428571429,7,"GO:0006497","BP","protein lipidation","The covalent attachment of lipid groups to an amino acid in a protein."]
["yellow",655,97,5,4.325822E-3,1,3,0.030927835,0.428571429,7,"GO:0045913","BP","positive regulation of carbohydrate metabolic process","Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate."]
["yellow",655,97,6,4.325822E-3,1,3,0.030927835,0.428571429,7,"GO:0030295","MF","protein kinase activator activity","Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein."]
["yellow",655,97,7,0.004610476,1,11,0.113402062,0.127906977,86,"GO:0000278","BP","mitotic cell cycle","Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent."]
["yellow",655,97,8,0.006446457,1,4,0.041237113,0.266666667,15,"GO:0045931","BP","positive regulation of mitotic cell cycle","Any process that activates or increases the rate or extent of progression through the mitotic cell cycle."]
["yellow",655,97,9,0.00665668,1,3,0.030927835,0.375,8,"GO:0042158","BP","lipoprotein biosynthetic process","The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids."]
["yellow",655,97,10,0.00665668,1,3,0.030927835,0.375,8,"GO:0019209","MF","kinase activator activity","Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule."]
["yellowgreen",137,14,1,0.001482996,1,2,0.142857143,0.25,8,"GO:0003429","BP","growth plate cartilage chondrocyte morphogenesis","The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized."]
["yellowgreen",137,14,2,0.00181334,1,4,0.285714286,0.054054054,74,"GO:0048589","BP","developmental growth","The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another."]
["yellowgreen",137,14,3,0.00236259,1,2,0.142857143,0.2,10,"GO:0003433","BP","chondrocyte development involved in endochondral bone morphogenesis","The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone."]
["yellowgreen",137,14,4,0.00236259,1,2,0.142857143,0.2,10,"GO:0060536","BP","cartilage morphogenesis","The process in which the anatomical structures of cartilage are generated and organized."]
["yellowgreen",137,14,5,0.004041694,1,2,0.142857143,0.153846154,13,"GO:0003418","BP","growth plate cartilage chondrocyte differentiation","The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage."]
["yellowgreen",137,14,6,0.005393304,1,2,0.142857143,0.133333333,15,"GO:0003413","BP","chondrocyte differentiation involved in endochondral bone morphogenesis","The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage."]
["yellowgreen",137,14,7,0.006136853,1,2,0.142857143,0.125,16,"GO:0002063","BP","chondrocyte development","The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate."]
["yellowgreen",137,14,8,0.006924725,1,2,0.142857143,0.117647059,17,"GO:0003417","BP","growth plate cartilage development","The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow."]
["yellowgreen",137,14,9,7.650273E-3,1,1,0.071428571,1,1,"GO:0014718","BP","positive regulation of satellite cell activation involved in skeletal muscle regeneration","Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate."]
["yellowgreen",137,14,10,7.650273E-3,1,1,0.071428571,1,1,"GO:0033234","BP","negative regulation of protein sumoylation","Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein."]

{"sheet":"Module KEGG analysis","index":2,"n_rows":14,"n_cols":11,"rows_kept":14}
[null,"ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count","moduleColor"]
[1,"hsa04080","Neuroactive ligand-receptor interaction","11/74","341/8063",0.000251698431333779,0.0392649552880695,0.0392649552880695,"5540/3354/2570/2837/680/1136/727/64106/2847/2925/4142",11,"darkred"]
[2,"hsa04978","Mineral absorption","5/88","59/8063",0.000434929804637909,0.0821654531251738,0.0788584844235414,"476/6546/30061/475/486",5,"darkgreen"]
[3,"hsa04120","Ubiquitin mediated proteolysis","7/88","140/8063",0.000805543658089939,0.0821654531251738,0.0788584844235414,"9320/29945/7322/7321/9063/7189/8945",7,"darkgreen"]
[4,"hsa05131","Shigellosis","9/88","242/8063",0.00123326755003801,0.0838621934025844,0.0804869348445857,"4735/3098/382/8976/7322/7321/7189/8945/6352",9,"darkgreen"]
[5,"hsa04964","Proximal tubule bicarbonate reclamation","3/88","23/8063",0.00189979261266951,0.0968894232461448,0.0929898489359285,"476/2746/486",3,"darkgreen"]
[6,"hsa05213","Endometrial cancer","6/154","58/8063",0.000785567717793419,0.0972589369847296,0.0873461631232952,"5728/5291/4292/5605/6655/1643",6,"purple"]
[7,"hsa04610","Complement and coagulation cascades","7/154","85/8063",0.00114806817543051,0.0972589369847296,0.0873461631232952,"5327/2153/7450/716/3689/1604/3426",7,"purple"]
[8,"hsa05210","Colorectal cancer","7/154","86/8063",1.23012585192663E-3,0.0972589369847296,0.0873461631232952,"5291/4292/5881/5605/6655/1643/2069",7,"purple"]
[9,"hsa04664","Fc epsilon RI signaling pathway","6/154","68/8063",0.0018168347280073,0.0972589369847296,0.0873461631232952,"5291/3635/5881/5605/6655/2534",6,"purple"]
[10,"hsa05224","Breast cancer","9/154","147/8063",0.00195698060364649,0.0972589369847296,0.0873461631232952,"5728/7471/5291/23493/5605/6655/7479/26508/1643",9,"purple"]
[11,"hsa05231","Choline metabolism in cancer","7/154","98/8063",0.00261895426946745,0.0972589369847296,0.0873461631232952,"126969/5291/56994/5881/5605/6655/5337",7,"purple"]
[12,"hsa04150","mTOR signaling pathway","9/154","155/8063",2.80816771708147E-3,0.0972589369847296,0.0873461631232952,"5728/7471/5291/253260/5605/6655/23175/7479/6396",9,"purple"]
[13,"hsa05166","Human T-cell leukemia virus 1 infection","11/154","219/8063",3.08758530110253E-3,0.0972589369847296,0.0873461631232952,"5728/51433/115650/5291/5533/7094/5605/6929/1031/1958/3689",11,"purple"]

{"sheet":"Sankeycharts","index":3,"n_rows":22,"n_cols":6,"rows_kept":22}
["ONTOLOGY","ID","Description","pathway classification","dirName","module"]
["BP","GO:0060602","branch elongation of an epithelium","cell migration","strengthL","purpleU"]
["BP","GO:0032332","positive regulation of chondrocyte differentiation","mineralization","strengthL","purpleU"]
["BP","GO:0048754","branching morphogenesis of an epithelial tube","cell migration","strengthL","purpleU"]
["BP","GO:0048568","embryonic organ development","reproductive organ development","strengthL","purpleU"]
["BP","GO:0048608","reproductive structure development","reproductive organ development","strengthL","purpleU"]
["BP","GO:0048732","gland development","Shell gland development","strengthL","purpleU"]
["BP","GO:0061458","reproductive system development","reproductive organ development","strengthL","purpleU"]
["BP","GO:0061138","morphogenesis of a branching epithelium","cell migration","strengthL","purpleU"]
["BP","GO:0001763","morphogenesis of a branching structure","cell migration","strengthL","purpleU"]
["BP","GO:0043491","protein kinase B signaling","cell cycle","strengthL","purpleU"]
["BP","GO:0060562","epithelial tube morphogenesis","cell migration","strengthL","purpleU"]
["BP","GO:0001701","in utero embryonic development","reproductive organ development","strengthL","purpleU"]
["BP","GO:0001503","ossification","mineralization","strengthL","purpleU"]
["BP","GO:0007173","epidermal growth factor receptor signaling pathway","cell cycle","strengthL","purpleU"]
["BP","GO:0022612","gland morphogenesis","Shell gland development","strengthL","purpleU"]
["BP","GO:0002062","chondrocyte differentiation","mineralization","strengthL","purpleU"]
["BP","GO:0050673","epithelial cell proliferation","cell cycle","strengthL","purpleU"]
["BP","GO:0030879","mammary gland development","reproductive organ development","strengthL","purpleU"]
["BP","GO:0035148","tube formation","reproductive organ development","strengthL","purpleU"]
["BP","GO:1901201","regulation of extracellular matrix assembly","cell cycle","strengthL","purpleU"]
["BP","GO:0002064","epithelial cell development","cell cycle","strengthL","purpleU"]

{"sheet":"genes in PPI analysis","index":4,"n_rows":106,"n_cols":1,"rows_kept":106}
["AREG"]
["PENK"]
["CTHRC1"]
["WNT11"]
["PTHLH"]
["FZD1"]
["JUND"]
["PTN"]
["GREM1"]
["SOX9"]
["ITGA11"]
["TOB1"]
["EPHA2"]
["ANO6"]
["BMP7"]
["WNT7B"]
["GDPD2"]
["ID4"]
["TGFB1"]
["NOCT"]
["MRC2"]
["SMAD3"]
["CHRD"]
["SUCO"]
["MSX2"]
["SNX10"]
["RORB"]
["BMPR1B"]
["ATP6V0A4"]
["KL"]
["TNC"]
["PHLDA2"]
["PKD2"]
["PLCD1"]
["CHST11"]
["KLF2"]
["CAPN2"]
["HNF1B"]
["MBD3"]
["NSDHL"]
["SOX6"]
["GATA3"]
["E2F7"]
["PLPP4"]
["GATA2"]
["HEY2"]
["SLC34A2"]
["FGF1"]
["ETV5"]
["MYC"]
["SPRY1"]
["VANGL2"]
["MET"]
["EPHA7"]
["DLG1"]
["WNT5B"]
["WNT7A"]
["VWA1"]
["SOX5"]
["SDC1"]
["TFCP2L1"]
["TJP2"]
["SLC4A7"]
["ARHGEF26"]
["SPDEF"]
["EREG"]
["BTC"]
["AFAP1L2"]
["ADRA2A"]
["PIGR"]
["SERPINB5"]
["SOSTDC1"]
["OXTR"]
["ATP7B"]
["CDO1"]
["DLC1"]
["SOX4"]
["IRX3"]
["HES5"]
["NOX4"]
["KLF4"]
["CCR7"]
["CRYBA1"]
["SEMA5A"]
["PIK3AP1"]
["F10"]
["NR4A3"]
["APELA"]
["TSHZ1"]
["RHOBTB3"]
["STC2"]
["EAF2"]
["ROBO2"]
["HTRA1"]
["TLR3"]
["TNFSF10"]
["GJB1"]
["JUN"]
["NR4A1"]
["THBS4"]
["EGR3"]
["NOX5"]
["VEGFD"]
["SGPP2"]
["HAS2"]
["STAT1"]