{"text_format":"1","workbook":"xlsx","n_sheets":5,"sheets":["Table S1","Table S2","Table S3","Table S4","Table S5"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Table S1","index":0,"n_rows":109,"n_cols":12,"rows_kept":109,"cut":false,"hidden":false,"merged":[[9,10,18,10],[7,0,40,0],[0,0,0,5],[1,8,1,9],[1,0,6,0],[41,0,104,0],[63,8,75,8],[76,8,78,8],[41,8,62,8],[27,8,40,8],[23,8,26,8],[20,8,22,8],[9,8,18,8],[9,9,18,9],[79,5,104,5],[79,8,104,8],[79,9,104,9],[79,10,104,10],[108,5,108,6],[20,9,22,9],[20,10,22,10],[23,10,26,10],[23,9,26,9],[27,9,40,9],[27,10,40,10],[41,9,62,9],[41,10,62,10],[63,9,75,9],[63,10,75,10],[76,9,78,9],[76,10,78,10]]}
["Table S1. All samples with I35T "]
["I35T in other tumours",null,"Gene","CDS Mutation","AA Mutation","COSMIC number/ Sample name","Tissue","Cell type","Linked paper",null,"PubMed ID"]
[null,1,"CTNNB1","c.104T>C","p.I35T",2579336,"Skin","Malignant melanoma","Siroy AE et al",2014,25148578]
[null,2,"CTNNB1","c.104T>C","p.I35T",2293769,"Adrenal gland","Adrenal cortical carcinoma","Assié G et al",2014,24747642]
[null,3,"CTNNB1","c.104T>C","p.I35T",1714145,"Kidney","Wilms tumour ","Scott RH et al",2012,22470196]
[null,4,"CTNNB1","c.104T>C","p.I35T","PAJMMZ","Kidney","Wilms tumour","Gadd S et al",2017,28825729]
[null,5,"CTNNB1","c.104T>C","p.I35T","Patient7234 (cBioPortal)","N/A","Rhabdomyosarcoma","N/A","N/A","N/A"]
["I35T in SG (from COSMIC)",6,"CTNNB1","c.104T>C","p.I35T",914546,"Salivary gland","Adenoid cystic carcinoma","Daa T et al",2004,15195113]
[null,7,"CTNNB1","c.104T>C","p.I35T",1042323,"Salivary gland","Adenoid cystic carcinoma","Daa T et al",2005,15943036]
[null,8,"CTNNB1","c.104T>C","p.I35T",1585378,"Parotid gland","Basal cell adenoma","Kawahara A et al",2011,21323741]
[null,9,"CTNNB1","c.104T>C","p.I35T",1585379,"Parotid gland","Basal cell adenoma"]
[null,10,"CTNNB1","c.104T>C","p.I35T",1585380,"Parotid gland","Basal cell adenoma"]
[null,11,"CTNNB1","c.104T>C","p.I35T",1585383,"Parotid gland","Basal cell adenoma"]
[null,12,"CTNNB1","c.104T>C","p.I35T",1585385,"Parotid gland","Basal cell adenoma"]
[null,13,"CTNNB1","c.104T>C","p.I35T",1585386,"Parotid gland","Basal cell adenoma"]
[null,14,"CTNNB1","c.104T>C","p.I35T",1585390,"Parotid gland","Basal cell adenoma"]
[null,15,"CTNNB1","c.104T>C","p.I35T",1585392,"Parotid gland","Basal cell adenoma"]
[null,16,"CTNNB1","c.104T>C","p.I35T",1585393,"Parotid gland","Basal cell adenoma"]
[null,17,"CTNNB1","c.104T>C","p.I35T",1585395,"Parotid gland","Basal cell adenoma"]
[null,18,"CTNNB1","c.104T>C","p.I35T",2377960,"Parotid gland","Epithelial-myoepithelial carcinoma","Grünewald I et al",2015,26053092]
[null,19,"CTNNB1","c.104T>C","p.I35T",2564418,"Parotid gland","Basal cell adenoma","Wilson TC et al",2016,27224988]
[null,20,"CTNNB1","c.104T>C","p.I35T",2564419,"Parotid gland","Basal cell adenoma"]
[null,21,"CTNNB1","c.104T>C","p.I35T",2564420,"Parotid gland","Basal cell adenoma"]
[null,22,"CTNNB1","c.104T>C","p.I35T",2602673,"Salivary gland","Basal cell adenoma","Jo VY et al",2016,27259009]
[null,23,"CTNNB1","c.104T>C","p.I35T",2602675,"Salivary gland","Basal cell adenoma"]
[null,24,"CTNNB1","c.104T>C","p.I35T",2602676,"Salivary gland","Basal cell adenoma"]
[null,25,"CTNNB1","c.104T>C","p.I35T",2602677,"Salivary gland","Basal cell adenoma"]
[null,26,"CTNNB1","c.104T>C","p.I35T",2729046,"Parotid gland","Basal cell adenoma","Sato M et al",2018,29496310]
[null,27,"CTNNB1","c.104T>C","p.I35T",2729047,"Parotid gland","Basal cell adenoma"]
[null,28,"CTNNB1","c.104T>C","p.I35T",2729048,"Parotid gland","Basal cell adenoma"]
[null,29,"CTNNB1","c.104T>C","p.I35T",2729049,"Parotid gland","Basal cell adenoma"]
[null,30,"CTNNB1","c.104T>C","p.I35T",2729050,"Parotid gland","Basal cell adenoma"]
[null,31,"CTNNB1","c.104T>C","p.I35T",2729051,"Parotid gland","Basal cell adenoma"]
[null,32,"CTNNB1","c.104T>C","p.I35T",2729052,"Parotid gland","Basal cell adenoma"]
[null,33,"CTNNB1","c.104T>C","p.I35T",2729053,"Parotid gland","Basal cell adenoma"]
[null,34,"CTNNB1","c.104T>C","p.I35T",2729054,"Parotid gland","Basal cell adenoma"]
[null,35,"CTNNB1","c.104T>C","p.I35T",2729055,"Parotid gland","Basal cell adenoma"]
[null,36,"CTNNB1","c.104T>C","p.I35T",2729056,"Parotid gland","Basal cell adenoma"]
[null,37,"CTNNB1","c.104T>C","p.I35T",2729057,"Parotid gland","Basal cell adenoma"]
[null,38,"CTNNB1","c.104T>C","p.I35T",2729058,"Parotid gland","Basal cell adenoma"]
[null,39,"CTNNB1","c.104T>C","p.I35T",2729080,"Parotid gland","Basal cell adenocarcinoma"]
["I35T in SG (from literature)",40,"CTNNB1","c.104T>C","p.I35T","BCA 1","Parotid gland","Basal cell adenoma","Lee et al",2018,29224720]
[null,41,"CTNNB1","c.104T>C","p.I35T","BCA 2","Parotid gland","Basal cell adenoma"]
[null,42,"CTNNB1","c.104T>C","p.I35T","BCA 3","Parotid gland","Basal cell adenoma"]
[null,43,"CTNNB1","c.104T>C","p.I35T","BCA 6","Parotid gland","Basal cell adenoma"]
[null,44,"CTNNB1","c.104T>C","p.I35T","BCA 9","Parotid gland","Basal cell adenoma"]
[null,45,"CTNNB1","c.104T>C","p.I35T","BCA 11","Parotid gland","Basal cell adenoma"]
[null,46,"CTNNB1","c.104T>C","p.I35T","BCA 15","Parotid gland","Basal cell adenoma"]
[null,47,"CTNNB1","c.104T>C","p.I35T","BCA 16","Parotid gland","Basal cell adenoma"]
[null,48,"CTNNB1","c.104T>C","p.I35T","BCA 18","Parotid gland","Basal cell adenoma"]
[null,49,"CTNNB1","c.104T>C","p.I35T","BCA 19","Parotid gland","Basal cell adenoma"]
[null,50,"CTNNB1","c.104T>C","p.I35T","BCA 20","Parotid gland","Basal cell adenoma"]
[null,51,"CTNNB1","c.104T>C","p.I35T","BCA 21","Parotid gland","Basal cell adenoma"]
[null,52,"CTNNB1","c.104T>C","p.I35T","BCA 22","Parotid gland","Basal cell adenoma"]
[null,53,"CTNNB1","c.104T>C","p.I35T","BCA 23","Parotid gland","Basal cell adenoma"]
[null,54,"CTNNB1","c.104T>C","p.I35T","BCA 29","Parotid gland","Basal cell adenoma"]
[null,55,"CTNNB1","c.104T>C","p.I35T","BCA 30","Parotid gland","Basal cell adenoma"]
[null,56,"CTNNB1","c.104T>C","p.I35T","BCA 31","Parotid gland","Basal cell adenoma"]
[null,57,"CTNNB1","c.104T>C","p.I35T","BCA 32","Parotid gland","Basal cell adenoma"]
[null,58,"CTNNB1","c.104T>C","p.I35T","BCA 36","Parotid gland","Basal cell adenoma"]
[null,59,"CTNNB1","c.104T>C","p.I35T","BCA 38","Parotid gland","Basal cell adenoma"]
[null,60,"CTNNB1","c.104T>C","p.I35T","BCA 39","Parotid gland","Basal cell adenoma"]
[null,61,"CTNNB1","c.104T>C","p.I35T","BCA 40","Parapharynx","Basal cell adenoma"]
[null,62,"CTNNB1","c.104T>C","p.I35T","BCA 1","Parotid gland","Basal cell adenoma","Oyama et al",2018,30053869]
[null,63,"CTNNB1","c.104T>C","p.I35T","BCA 4","Parotid gland","Basal cell adenoma"]
[null,64,"CTNNB1","c.104T>C","p.I35T","BCA 5","Parotid gland","Basal cell adenoma"]
[null,65,"CTNNB1","c.104T>C","p.I35T","BCA 10","Parotid gland","Basal cell adenoma"]
[null,66,"CTNNB1","c.104T>C","p.I35T","BCA 17","Parotid gland","Basal cell adenoma"]
[null,67,"CTNNB1","c.104T>C","p.I35T","BCA 20","Parotid gland","Basal cell adenoma"]
[null,68,"CTNNB1","c.104T>C","p.I35T","BCA 21","Parotid gland","Basal cell adenoma"]
[null,69,"CTNNB1","c.104T>C","p.I35T","BCA 22","Parotid gland","Basal cell adenoma"]
[null,70,"CTNNB1","c.104T>C","p.I35T","BCA 24","Parotid gland","Basal cell adenoma"]
[null,71,"CTNNB1","c.104T>C","p.I35T","BCA 32","Parotid gland","Basal cell adenoma"]
[null,72,"CTNNB1","c.104T>C","p.I35T","BCA 33","Parotid gland","Basal cell adenoma"]
[null,73,"CTNNB1","c.104T>C","p.I35T","BCAC 1","Parotid gland","Basal cell adenocarcinoma"]
[null,74,"CTNNB1","c.104T>C","p.I35T","BCAC 2","Parotid gland","Basal cell adenocarcinoma"]
[null,75,"CTNNB1","c.104T>C","p.I35T","Case 2","Parotid gland","Hyperplastic intercalated duct lesion","McLean et al",2022,36480093]
[null,76,"CTNNB1","c.104T>C","p.I35T","Case 3","Parotid gland","Hyperplastic intercalated duct lesion"]
[null,77,"CTNNB1","c.104T>C","p.I35T","Case 9","Parotid gland","Hybrid intercalated duct lesion"]
[null,78,"CTNNB1","c.104T>C","p.I35T","N/A","Parotid gland","Basal cell adenoma","Wong et al.",2024,"Preprint: https://doi.org/10.1101/2024.10.21.619442\n"]
[null,79,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,80,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,81,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,82,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,83,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,84,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,85,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,86,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,87,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,88,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,89,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,90,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,91,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,92,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,93,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,94,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,95,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,96,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,97,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,98,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,99,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenoma"]
[null,100,"CTNNB1","c.104T>C","p.I35T",null,"Submandibular gland","Basal cell adenoma"]
[null,101,"CTNNB1","c.104T>C","p.I35T",null,"Submandibular gland","Basal cell adenoma"]
[null,102,"CTNNB1","c.104T>C","p.I35T",null,"Cheek","Basal cell adenoma"]
[null,103,"CTNNB1","c.104T>C","p.I35T",null,"Parotid gland","Basal cell adenocarcinoma/ \nEpithelial-myoepithelial carcinoma",null,null,null,"Tumour also had HRAS, KMT2D, PIK3CA and ARID1A and biallelic MLH1 variants"]
[]
[]
[]
[null,null,"IDH = 3/103 = 2.9%","BCA = 88/103 = 85.4%","BCAC = 4/103 = 3.9%","SG tumours = 98/103 = 95.1%"]

{"sheet":"Table S2","index":1,"n_rows":20,"n_cols":40,"rows_kept":20,"cut":false,"hidden":false,"merged":[[15,28,15,30],[14,28,14,30],[6,3,6,7],[8,18,8,22],[8,23,8,27],[15,3,15,7],[11,28,11,30],[3,28,3,30],[7,28,7,30],[9,28,9,30],[5,28,5,30],[1,3,1,7],[0,1,0,8],[1,8,1,12],[1,18,1,22],[1,23,1,27],[1,13,1,17],[1,36,2,37],[5,8,5,12],[5,23,5,27],[5,18,5,22],[11,23,11,27],[7,23,7,27],[9,23,9,27],[11,18,11,22],[7,18,7,22],[9,18,9,22],[1,31,2,31],[1,32,2,32],[1,33,2,33],[1,34,2,35],[1,28,1,30],[4,28,4,30],[24,1,24,6],[16,3,16,7],[16,8,16,12],[16,23,16,27],[16,18,16,22],[17,23,17,27],[17,3,17,7],[17,8,17,12],[17,18,17,22],[19,0,19,2],[20,3,20,7],[15,0,18,0],[16,13,16,17],[17,13,17,17],[18,13,18,17],[3,3,3,7],[3,23,3,27],[6,18,6,22],[6,23,6,27],[12,3,12,7],[12,18,12,22],[12,23,12,27],[12,8,12,12],[4,3,4,7],[4,8,4,12],[4,23,4,27],[3,8,3,12],[14,8,14,12],[15,8,15,12],[15,23,15,27],[14,3,14,7],[14,13,14,17],[15,13,15,17],[21,3,21,7],[18,38,18,39],[18,3,18,7],[18,8,18,12],[18,18,18,22],[18,23,18,27],[3,0,13,0],[13,18,13,22],[13,23,13,27],[13,28,13,30],[3,13,3,17],[4,13,4,17],[5,13,5,17],[6,13,6,17],[7,13,7,17],[8,13,8,17],[9,13,9,17],[10,13,10,17],[11,13,11,17],[13,13,13,17],[10,28,10,30],[8,28,8,30]]}
[null,"Table S2. CTNNB1 variants in salivary gland (SG) tumours"]
[null,null,null,"Basal Cell Adenoma (BCA)",null,null,null,null,"Basal Cell Adenocarcinoma (BCAC)",null,null,null,null,"Intercalated Duct Hyperplasia (IDH)",null,null,null,null,"Adenoid Cystic Carcinoma (ACC)",null,null,null,null,"Pleomorphic adenoma (PA)",null,null,null,null,"Other SG tumours",null,null,"Grand Total \nI35T","Grand Total \nSamples with CTNNB1 var.","Grand Total\nN.o of samples tested","N.o of I35T/Grand Total Samples with CTNNB1 var.",null,"N.o of I35T/Grand total of samples tested"]
[null,"References","PubMed ID","I35T","Other CTNNB1 var.","Total n.o BCA samples tested","% I35T/Total CTNNB1-mutated samples","% I35T/Total BCA samples","I35T","Other CTNNB1 var.","Total n.o BCAC samples tested","% I35T/Total CTNNB1-mutated samples","% I35T/Total BCAC samples","I35T","Other CTNNB1 var.","Total n.o IDH samples tested","% I35T/Total CTNNB1-mutated samples","% I35T/Total IDH samples","I35T","Samples with other CTNNB1 var.","Total n.o ACC samples tested","% I35T/Total CTNNB1-mutated samples","% I35T/Total ACC samples","I35T","Samples with other CTNNB1 var.","Total n.o \nPA samples tested","% I35T/Total CTNNB1-mutated samples","% I35T/Total PA samples","I35T","Samples with other CTNNB1 var.","Total n.o \nSG samples tested"]
["Papers with at least 1 I35T sample","Daa et al. (2004)",15195113,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,1,0,20,{"$f":"S4/(S4+T4)","v":1},{"$f":"S4/U4","v":0.05},"N/A",null,null,null,null,"N/A",null,null,1,1,20,"1/1",{"$f":"AF4/AG4","v":1},"1/20",{"$f":"AF4/AH4","v":0.05}]
[null,"Daa et al. (2005)",15943036,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,1,0,23,{"$f":"S5/(S5+T5)","v":1},{"$f":"S5/U5","v":4.3478260869565216E-2},"N/A",null,null,null,null,"N/A",null,null,1,1,23,"1/1",1,"1/23",4.3478260869565216E-2]
[null,"Kawahara et al. (2011)",21323741,10,1,22,{"$f":"D6/(D6+E6)","v":0.90909090909090906},{"$f":"D6/F6","v":0.45454545454545453},"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,10,{"$f":"D6+E6","v":11},22,"10/11",0.90909090909090906,"10/22",0.45454545454545453]
[null,"Grünewald et al. (2015)",26053092,"N/A",null,null,null,null,0,0,4,0,{"$f":"I7/K7","v":0},"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,1,0,80,1,1,{"$f":"K7+AE7","v":84},"1/1",1,"1/84",1.1904761904761904E-2]
[null,"Wilson et al. (2016)",27224988,3,0,8,{"$f":"D8/(D8+E8)","v":1},{"$f":"D8/F8","v":0.375},0,0,9,0,0,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,3,3,{"$f":"F8+K8","v":17},"3/3",1,"3/17",0.17647058823529413]
[null,"Jo Vy et al. (2016)",27259009,4,0,5,{"$f":"D9/(D9+E9)","v":1},{"$f":"D9/F9","v":0.8},0,0,1,0,0,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,4,4,{"$f":"F9+K9","v":6},"4/4",1,"4/6",0.66666666666666663]
[null,"Lee et al. (2018)",29224720,22,2,40,{"$f":"D10/(D10+E10)","v":0.91666666666666663},{"$f":"D10/F10","v":0.55000000000000004},0,0,2,0,0,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,22,{"$f":"D10+E10","v":24},{"$f":"F10+K10","v":42},"22/24",{"$f":"AF10/AG10","v":0.91666666666666663},"22/42",{"$f":"AF10/AH10","v":0.52380952380952384}]
[null,"Sato et al. (2018)",29496310,13,1,34,{"$f":"D11/(D11+E11)","v":0.9285714285714286},{"$f":"D11/F11","v":0.38235294117647056},1,0,3,{"$f":"I11/(I11+J11)","v":1},{"$f":"I11/K11","v":0.33333333333333331},"N/A",null,null,null,null,0,0,67,0,0,0,0,31,0,0,"N/A",null,null,{"$f":"D11+I11+S11+X11","v":14},{"$f":"D11+E11+I11","v":15},{"$f":"F11+K11+U11+Z11","v":135},"14/15",{"$f":"AF11/AG11","v":0.93333333333333335},"14/135",{"$f":"AF11/AH11","v":0.1037037037037037}]
[null,"Oyama et al. (2018)",30053869,11,1,35,{"$f":"D12/(D12+E12)","v":0.91666666666666663},{"$f":"D12/F12","v":0.31428571428571428},2,0,4,{"$f":"I12/(I12+J12)","v":1},{"$f":"I12/K12","v":0.5},"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,{"$f":"D12+I12","v":13},{"$f":"D12+E12+I12","v":14},{"$f":"F12+K12","v":39},"13/34",0.9285714285714286,"13/39",0.33333333333333331]
[null,"McLean et al. (2022)",36480093,"N/A",null,null,null,null,"N/A",null,null,null,null,3,0,15,{"$f":"N13/N13+O13","v":1},{"$f":"N13/P13","v":0.2},"N/A",null,null,null,null,"N/A",null,null,null,null,3,0,15,3,3,15,"3/3",{"$f":"AF13/AG13","v":1},"3/15",{"$f":"AF13/AH13","v":0.2}]
[null,"Wong et al. (2024)","Preprint: https://doi.org/10.1101/2024.10.21.619442",25,0,32,{"$f":"D14/(D14+E14)","v":1},{"$f":"D14/F14","v":0.78125},1,0,7,{"$f":"I14/(I14+J14)","v":1},{"$f":"I14/K14","v":0.14285714285714285},"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,{"$f":"D14+I14","v":26},{"$f":"D14+I14","v":26},{"$f":"F14+K14","v":39},"26/26",{"$f":"AF14/AG14","v":1},"26/39",{"$f":"AF14/AH14","v":0.66666666666666663}]
["CTNNB1 var not specified","Cavalcante et al. (2018)",29577164,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"Specific var. not provided",7,24,"N/A","N/A","Specific var. not provided",6,24,"N/A","N/A","N/A",null,null,0,{"$f":"T15+Y15","v":13},{"$f":"U15+Z15","v":48},"N/A","N/A","N/A","N/A"]
["Papers with CTNNB1 var other than I35T","Ho et al. (2013)",23685749,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,0,1,60,0,0,"N/A",null,null,null,null,"N/A",null,null,0,1,60,"0/1",0,"0/60",0]
[null,"Wang et al. (2016)",27334835,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,0,1,149,0,1,149,"0/1",0,"0/149",0]
[null,"Zehir et al. (2017)",28481359,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,0,1,113,0,1,113,"0/1",0,"0/113",0]
[null,"Dalin et al. (2016)",27103403,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,"N/A",null,null,null,null,0,"1\n(2 var in 1 sample)",31,0,1,31,"0/1",0,"0/31",0,"Samples with CTNNB1 var/Grand total of samples tested"]
["Total",null,null,{"$f":"SUM(D6,D8,D10,D9,D11,D12,D14)","v":88},{"$f":"SUM(E6,E8,E10,E9,E11,E12,E14)","v":5},{"$f":"SUM(F6,F8,F10,F9,F11,F12,F14)","v":176},{"$f":"D20/(D20+E20)","v":0.94623655913978499},{"$f":"D20/F20","v":0.5},{"$f":"SUM(I7:I12,I14)","v":4},{"$f":"SUM(J7:J12,J14)","v":0},{"$f":"SUM(K7:K12,K14)","v":30},{"$f":"I20/(I20+J20)","v":1},{"$f":"I20/K20","v":0.13333333333333333},3,0,15,{"$f":"N20/N20+O20","v":1},{"$f":"N20/P20","v":0.2},{"$f":"SUM(S4,S5,S11,S16)","v":2},{"$f":"SUM(T4,T5,T11,T16,T15)","v":8},{"$f":"SUM(U4,U5,U11,U16,U15)","v":194},{"$f":"S20/T20","v":0.25},{"$f":"S20/U20","v":1.0309278350515464E-2},0,6,{"$f":"SUM(Z11,Z15)","v":55},{"$f":"X20/Y20","v":0},{"$f":"X20/Z20","v":0},1,3,{"$f":"SUM(AE7,AE13,AE17,AE18,AE19)","v":388},{"$f":"SUM(AF4:AF19)","v":98},{"$f":"SUM(AG4:AG19)","v":120},{"$f":"SUM(AH4:AH19)","v":843},"98/120",{"$f":"AF20/AG20","v":0.81666666666666665},"98/843",{"$f":"AF20/AH20","v":0.1162514827995255},"120/843",{"$f":"AG20/AH20","v":0.14234875444839859}]

{"sheet":"Table S3","index":2,"n_rows":10,"n_cols":5,"rows_kept":10,"cut":false,"hidden":false,"merged":[[1,2,1,4],[8,0,9,0],[3,0,6,0],[1,1,2,1],[0,1,0,3]]}
[null,"Table S3. Number of 20-AAR domains retained in family's tumours"]
[null,"Tumour","Number of 20-AARs"]
[null,null,"Germline","Somatic","Total"]
["Proband ","BCA",3,0,3]
[null,"Parotid BCACs (bilateral)",3,3,6]
[null,"Submandibular BCAC",3,7,10]
[null,"Colon polyp",3,1,4]
["Sister","BCA",3,4,7]
["Mother","Colon polyp",3,0,3]
[null,"CRC",3,2,5]

{"sheet":"Table S4","index":3,"n_rows":4,"n_cols":5,"rows_kept":4,"cut":false,"hidden":false,"merged":[[2,4,2,7],[0,0,0,2]]}
["Table S4. Contingency table of CTNNB1 I35T in salivary gland tumours"]
[null,"Salivary Glands","Other sites"]
["CTNNB1 I35T",72,5,null,"p value (c-square test) <2.2 x 10-16"]
["Other CTNNB1 variants seen in salivary glands",22,91]

{"sheet":"Table S5","index":4,"n_rows":13,"n_cols":9,"rows_kept":13,"cut":false,"hidden":false,"merged":[[12,0,12,3],[0,2,0,9],[11,2,11,3],[9,4,10,4],[9,7,10,7],[3,7,4,7],[3,8,4,8],[9,8,10,8]]}
[null,null,"Table S5. List of CTNNB1 variants other than I35T seen in salivary glands (SG)"]
[null,"Gene","CDS Mutation","AA Mutation","Number of cases reported in SG","Number of cases reported in other tissues (COSMIC)","COSMIC Reference","References ","PubMed ID"]
[1,"CTNNB1","c.121A>C","p.T41P",2,8,"COSM5688; COSM36385","Kawahara et al.; Sato et al.","1585387; 29496310"]
[2,"CTNNB1","c.82C>T","p.Q28P",1,0,"N/A","Lee et al.",29224720]
[3,"CTNNB1","c.123_125del","p.T42*",1,0,"N/A"]
[4,"CTNNB1","c.107A>C","p.H36P",1,71,"COSM5678; COSM29403","Oyama et al.",30053869]
[5,"CTNNB1","c.1982G>T","p.R661L",1,0,"COSM1644523","Ho et al.",23685749]
[6,"CTNNB1","c.770C>T","p.T257I",1,5,"COSM188059","Wang et al.",27334835]
[7,"CTNNB1","c.998A>T","p.Y333F",1,7,"COSM3738527","Zehir et al.",28481359]
[8,"CTNNB1","c.1789C>A","p.P597T",1,0,"COSM5988212","Dalin et al.",27103403]
[9,"CTNNB1","c.2dup","p.M1?",null,0,"COSM5988211"]
[10,"CTNNB1","Not specified",null,13,"N/A","N/A","Cavalcante et al.",29577164]
["Total numbers used in contigency table (Table S4)",null,null,null,{"$f":"SUM(E3:E12)","v":22},{"$f":"SUM(F3:F12)","v":91}]