| ONTOLOGY |
ID |
Description |
GeneRatio |
BgRatio |
pvalue |
p.adjust |
qvalue |
geneID |
Count |
| BP |
GO:0062197 |
cellular response to chemical stress |
20/49 |
345/18903 |
1.70E-22 |
5.11E-19 |
1.81E-19 |
TNF/IL6/AKT1/EGFR/SRC/MMP9/CASP3/MAPK3/PTGS2/MAPK1/PIK3CA/JAK2/HGF/MAPK8/SIRT1/MPO/CASP1/HMOX1/NOS3/MMP3 |
20 |
| BP |
GO:0032496 |
response to lipopolysaccharide |
19/49 |
339/18903 |
4.62E-21 |
6.96E-18 |
2.47E-18 |
TNF/IL6/AKT1/SRC/CASP3/MAPK3/PTGS2/MAPK1/RHOA/JAK2/CCL5/MAPK8/MPO/MAPK14/CASP1/CASP8/ACE/NOS3/SELE |
19 |
| BP |
GO:0002237 |
response to molecule of bacterial origin |
19/49 |
360/18903 |
1.44E-20 |
1.45E-17 |
5.15E-18 |
TNF/IL6/AKT1/SRC/CASP3/MAPK3/PTGS2/MAPK1/RHOA/JAK2/CCL5/MAPK8/MPO/MAPK14/CASP1/CASP8/ACE/NOS3/SELE |
19 |
| BP |
GO:0033002 |
muscle cell proliferation |
17/49 |
247/18903 |
2.43E-20 |
1.83E-17 |
6.49E-18 |
TNF/IL6/AKT1/SRC/MMP9/PTGS2/IGF1/STAT1/RHOA/PIK3CA/JAK2/CCL5/HGF/IGF1R/MAPK14/HMOX1/NOS3 |
17 |
| BP |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
13/49 |
98/18903 |
1.93E-19 |
1.03E-16 |
3.65E-17 |
TNF/IL6/AKT1/SRC/MMP9/PTGS2/IGF1/STAT1/PIK3CA/JAK2/CCL5/IGF1R/HMOX1 |
13 |
| BP |
GO:0048660 |
regulation of smooth muscle cell proliferation |
15/49 |
175/18903 |
2.05E-19 |
1.03E-16 |
3.65E-17 |
TNF/IL6/AKT1/SRC/MMP9/PTGS2/IGF1/STAT1/RHOA/PIK3CA/JAK2/CCL5/IGF1R/HMOX1/NOS3 |
15 |
| BP |
GO:0048659 |
smooth muscle cell proliferation |
15/49 |
179/18903 |
2.90E-19 |
1.25E-16 |
4.43E-17 |
TNF/IL6/AKT1/SRC/MMP9/PTGS2/IGF1/STAT1/RHOA/PIK3CA/JAK2/CCL5/IGF1R/HMOX1/NOS3 |
15 |
| BP |
GO:0006979 |
response to oxidative stress |
19/49 |
434/18903 |
4.89E-19 |
1.84E-16 |
6.53E-17 |
TNF/IL6/AKT1/EGFR/SRC/MMP9/CASP3/MAPK3/PTGS2/STAT1/MAPK1/JAK2/HGF/MAPK8/SIRT1/MPO/HMOX1/NOS3/MMP3 |
19 |
| BP |
GO:0014065 |
phosphatidylinositol 3-kinase signaling |
14/49 |
145/18903 |
6.90E-19 |
2.31E-16 |
8.20E-17 |
TNF/AKT1/EGFR/SRC/IGF1/KDR/PIK3CA/KIT/JAK2/CCL5/HGF/SIRT1/IGF1R/FLT1 |
14 |
| BP |
GO:0000302 |
response to reactive oxygen species |
15/49 |
204/18903 |
2.13E-18 |
6.41E-16 |
2.28E-16 |
IL6/AKT1/EGFR/SRC/MMP9/CASP3/MAPK3/STAT1/MAPK1/HGF/MAPK8/SIRT1/MPO/HMOX1/NOS3 |
15 |
| BP |
GO:0034599 |
cellular response to oxidative stress |
16/49 |
288/18903 |
1.18E-17 |
3.24E-15 |
1.15E-15 |
TNF/IL6/AKT1/EGFR/SRC/MMP9/MAPK3/MAPK1/JAK2/HGF/MAPK8/SIRT1/MPO/HMOX1/NOS3/MMP3 |
16 |
| BP |
GO:0048015 |
phosphatidylinositol-mediated signaling |
14/49 |
178/18903 |
1.30E-17 |
3.27E-15 |
1.16E-15 |
TNF/AKT1/EGFR/SRC/IGF1/KDR/PIK3CA/KIT/JAK2/CCL5/HGF/SIRT1/IGF1R/FLT1 |
14 |
| BP |
GO:0048017 |
inositol lipid-mediated signaling |
14/49 |
182/18903 |
1.79E-17 |
3.96E-15 |
1.40E-15 |
TNF/AKT1/EGFR/SRC/IGF1/KDR/PIK3CA/KIT/JAK2/CCL5/HGF/SIRT1/IGF1R/FLT1 |
14 |
| BP |
GO:0042060 |
wound healing |
18/49 |
442/18903 |
1.84E-17 |
3.96E-15 |
1.40E-15 |
TNF/IL6/SRC/CASP3/IGF1/KDR/ANXA5/RHOA/PIK3CA/HRAS/JAK2/ITGB1/MAPK14/SYK/HMOX1/LCK/NOS3/PLAU |
18 |
| BP |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
17/49 |
380/18903 |
3.62E-17 |
7.28E-15 |
2.58E-15 |
TNF/IL6/EGFR/SRC/MAPK3/IGF1/KDR/KIT/JAK2/CCL5/HGF/IGF1R/SYK/LCK/ACE/FLT1/JAK1 |
17 |
| BP |
GO:0018212 |
peptidyl-tyrosine modification |
17/49 |
382/18903 |
3.96E-17 |
7.45E-15 |
2.64E-15 |
TNF/IL6/EGFR/SRC/MAPK3/IGF1/KDR/KIT/JAK2/CCL5/HGF/IGF1R/SYK/LCK/ACE/FLT1/JAK1 |
17 |
| BP |
GO:0034612 |
response to tumor necrosis factor |
15/49 |
254/18903 |
5.82E-17 |
1.03E-14 |
3.66E-15 |
TNF/AKT1/CASP3/MAPK3/PTGS2/STAT1/MAPK1/JAK2/CCL5/SIRT1/MAPK14/SYK/CASP1/CASP8/SELE |
15 |
| BP |
GO:0014066 |
regulation of phosphatidylinositol 3-kinase signaling |
12/49 |
111/18903 |
7.02E-17 |
1.18E-14 |
4.17E-15 |
TNF/EGFR/SRC/IGF1/KDR/KIT/JAK2/CCL5/HGF/SIRT1/IGF1R/FLT1 |
12 |
| BP |
GO:0050900 |
leukocyte migration |
17/49 |
398/18903 |
7.86E-17 |
1.25E-14 |
4.42E-15 |
TNF/IL6/AKT1/SRC/MMP9/MAPK3/MAPK1/RHOA/KIT/ITGB1/CCL5/SYK/HMOX1/LCK/SELE/FLT1/LGALS3 |
17 |
| BP |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
11/49 |
80/18903 |
9.77E-17 |
1.47E-14 |
5.22E-15 |
TNF/SRC/IGF1/KDR/KIT/JAK2/CCL5/HGF/SIRT1/IGF1R/FLT1 |
11 |
| BP |
GO:0009612 |
response to mechanical stimulus |
14/49 |
211/18903 |
1.45E-16 |
2.07E-14 |
7.36E-15 |
TNF/SRC/MAPK3/PTGS2/STAT1/RHOA/PIK3CA/KIT/MAPK8/IGF1R/MPO/MAPK14/CASP1/CASP8 |
14 |
| BP |
GO:0050673 |
epithelial cell proliferation |
17/49 |
481/18903 |
1.82E-15 |
2.50E-13 |
8.87E-14 |
TNF/IL6/AKT1/EGFR/IGF1/ESR1/KDR/STAT1/MAPK1/KIT/HRAS/HGF/SIRT1/HMOX1/PGR/FLT1/AR |
17 |
| BP |
GO:0071216 |
cellular response to biotic stimulus |
14/49 |
261/18903 |
2.83E-15 |
3.59E-13 |
1.27E-13 |
TNF/IL6/AKT1/SRC/MAPK3/MAPK1/RHOA/JAK2/CCL5/MAPK8/MAPK14/SYK/CASP1/NOS3 |
14 |
| BP |
GO:0034614 |
cellular response to reactive oxygen species |
12/49 |
150/18903 |
2.86E-15 |
3.59E-13 |
1.27E-13 |
IL6/AKT1/EGFR/SRC/MMP9/MAPK3/MAPK1/HGF/MAPK8/SIRT1/MPO/NOS3 |
12 |
| BP |
GO:0033674 |
positive regulation of kinase activity |
17/49 |
496/18903 |
3.03E-15 |
3.65E-13 |
1.29E-13 |
TNF/AKT1/EGFR/SRC/IGF1/KDR/RHOA/PIK3CA/KIT/HRAS/JAK2/CCL5/SIRT1/IGF1R/SYK/ACE/FLT1 |
17 |
| BP |
GO:0071214 |
cellular response to abiotic stimulus |
15/49 |
335/18903 |
3.57E-15 |
3.79E-13 |
1.35E-13 |
MMP9/CASP3/MAPK3/PTGS2/PIK3CA/HRAS/MDM2/MAPK8/SIRT1/IGF1R/MAPK14/CASP1/CASP8/MMP3/MMP1 |
15 |
| BP |
GO:0104004 |
cellular response to environmental stimulus |
15/49 |
335/18903 |
3.57E-15 |
3.79E-13 |
1.35E-13 |
MMP9/CASP3/MAPK3/PTGS2/PIK3CA/HRAS/MDM2/MAPK8/SIRT1/IGF1R/MAPK14/CASP1/CASP8/MMP3/MMP1 |
15 |
| BP |
GO:0050727 |
regulation of inflammatory response |
16/49 |
414/18903 |
3.64E-15 |
3.79E-13 |
1.35E-13 |
TNF/IL6/SRC/MMP9/PTGS2/IGF1/ESR1/JAK2/CCL5/HGF/MAPK14/SYK/CASP1/ACE/MMP3/SELE |
16 |
| BP |
GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process |
13/49 |
205/18903 |
3.65E-15 |
3.79E-13 |
1.35E-13 |
TNF/AKT1/SRC/MMP9/PTGS2/RHOA/JAK2/HGF/SIRT1/SYK/CASP1/CASP8/LCK |
13 |
| BP |
GO:0048545 |
response to steroid hormone |
15/49 |
339/18903 |
4.26E-15 |
4.28E-13 |
1.52E-13 |
TNF/IL6/SRC/CASP3/PTGS2/ESR1/RHOA/PIK3CA/JAK2/SIRT1/IGF1R/ACE/PGR/NR3C1/AR |
15 |
| BP |
GO:0071222 |
cellular response to lipopolysaccharide |
13/49 |
222/18903 |
1.03E-14 |
9.99E-13 |
3.54E-13 |
TNF/IL6/AKT1/SRC/MAPK3/MAPK1/RHOA/JAK2/CCL5/MAPK8/MAPK14/CASP1/NOS3 |
13 |
| BP |
GO:2001233 |
regulation of apoptotic signaling pathway |
15/49 |
374/18903 |
1.80E-14 |
1.70E-12 |
6.03E-13 |
TNF/AKT1/SRC/MMP9/PTGS2/IGF1/JAK2/MDM2/HGF/SIRT1/HMOX1/LCK/NOS3/AR/LGALS3 |
15 |
| BP |
GO:2001234 |
negative regulation of apoptotic signaling pathway |
13/49 |
233/18903 |
1.92E-14 |
1.75E-12 |
6.23E-13 |
TNF/AKT1/SRC/MMP9/PTGS2/IGF1/MDM2/HGF/SIRT1/HMOX1/NOS3/AR/LGALS3 |
13 |
| BP |
GO:0071219 |
cellular response to molecule of bacterial origin |
13/49 |
234/18903 |
2.03E-14 |
1.80E-12 |
6.39E-13 |
TNF/IL6/AKT1/SRC/MAPK3/MAPK1/RHOA/JAK2/CCL5/MAPK8/MAPK14/CASP1/NOS3 |
13 |
| BP |
GO:2000116 |
regulation of cysteine-type endopeptidase activity |
13/49 |
235/18903 |
2.15E-14 |
1.85E-12 |
6.56E-13 |
TNF/AKT1/SRC/MMP9/PTGS2/RHOA/JAK2/HGF/SIRT1/SYK/CASP1/CASP8/LCK |
13 |
| BP |
GO:0001819 |
positive regulation of cytokine production |
16/49 |
486/18903 |
4.38E-14 |
3.67E-12 |
1.30E-12 |
TNF/IL6/GAPDH/SRC/PTGS2/STAT1/KIT/HRAS/JAK2/HGF/SIRT1/MAPK14/SYK/CASP1/HMOX1/CASP8 |
16 |
| BP |
GO:0022407 |
regulation of cell-cell adhesion |
16/49 |
490/18903 |
4.97E-14 |
4.05E-12 |
1.44E-12 |
TNF/IL6/AKT1/SRC/CASP3/IGF1/RHOA/PIK3CA/JAK2/CCL5/MAPK14/SYK/LCK/SELE/JAK1/LGALS3 |
16 |
| BP |
GO:0038083 |
peptidyl-tyrosine autophosphorylation |
7/49 |
21/18903 |
5.69E-14 |
4.51E-12 |
1.60E-12 |
EGFR/SRC/MAPK3/KDR/IGF1R/LCK/ACE |
7 |
| BP |
GO:0043410 |
positive regulation of MAPK cascade |
16/49 |
496/18903 |
6.00E-14 |
4.63E-12 |
1.64E-12 |
TNF/IL6/EGFR/SRC/MAPK3/IGF1/KDR/KIT/HRAS/JAK2/CCL5/HGF/IGF1R/SYK/FLT1/AR |
16 |
| BP |
GO:0007159 |
leukocyte cell-cell adhesion |
15/49 |
414/18903 |
7.95E-14 |
5.99E-12 |
2.12E-12 |
TNF/IL6/AKT1/SRC/CASP3/IGF1/RHOA/PIK3CA/JAK2/ITGB1/CCL5/SYK/LCK/SELE/LGALS3 |
15 |
| BP |
GO:0045860 |
positive regulation of protein kinase activity |
15/49 |
420/18903 |
9.80E-14 |
7.20E-12 |
2.56E-12 |
TNF/AKT1/EGFR/SRC/IGF1/RHOA/PIK3CA/KIT/HRAS/JAK2/CCL5/SIRT1/SYK/ACE/FLT1 |
15 |
| BP |
GO:0048732 |
gland development |
15/49 |
441/18903 |
1.99E-13 |
1.43E-11 |
5.06E-12 |
TNF/IL6/AKT1/EGFR/SRC/MAPK3/ESR1/MAPK1/PIK3CA/JAK2/HGF/HMOX1/PGR/NR3C1/AR |
15 |
| BP |
GO:0009314 |
response to radiation |
15/49 |
452/18903 |
2.84E-13 |
1.99E-11 |
7.06E-12 |
TNF/AKT1/EGFR/MMP9/CASP3/PTGS2/KIT/HRAS/ITGB1/MDM2/MAPK8/SIRT1/MAPK14/MMP3/MMP1 |
15 |
| BP |
GO:0070997 |
neuron death |
14/49 |
368/18903 |
3.20E-13 |
2.19E-11 |
7.78E-12 |
TNF/GAPDH/AKT1/CASP3/KDR/RHOA/PIK3CA/HRAS/JAK2/CCL5/SIRT1/HMOX1/CASP8/NR3C1 |
14 |
| BP |
GO:0031960 |
response to corticosteroid |
11/49 |
165/18903 |
3.50E-13 |
2.32E-11 |
8.25E-12 |
TNF/IL6/SRC/CASP3/PTGS2/RHOA/PIK3CA/JAK2/IGF1R/ACE/NR3C1 |
11 |
| BP |
GO:0052547 |
regulation of peptidase activity |
15/49 |
459/18903 |
3.55E-13 |
2.32E-11 |
8.25E-12 |
TNF/GAPDH/AKT1/SRC/MMP9/PTGS2/RHOA/JAK2/HGF/SIRT1/SYK/CASP1/CASP8/LCK/CTSB |
15 |
| BP |
GO:0046777 |
protein autophosphorylation |
12/49 |
226/18903 |
3.98E-13 |
2.55E-11 |
9.05E-12 |
AKT1/EGFR/SRC/MAPK3/KDR/KIT/JAK2/IGF1R/SYK/LCK/ACE/FLT1 |
12 |
| BP |
GO:1903037 |
regulation of leukocyte cell-cell adhesion |
14/49 |
377/18903 |
4.44E-13 |
2.79E-11 |
9.90E-12 |
TNF/IL6/AKT1/SRC/CASP3/IGF1/RHOA/PIK3CA/JAK2/CCL5/SYK/LCK/SELE/LGALS3 |
14 |
| BP |
GO:0071356 |
cellular response to tumor necrosis factor |
12/49 |
234/18903 |
6.01E-13 |
3.70E-11 |
1.31E-11 |
TNF/AKT1/MAPK3/STAT1/MAPK1/JAK2/CCL5/SIRT1/MAPK14/SYK/CASP1/CASP8 |
12 |
| BP |
GO:0018105 |
peptidyl-serine phosphorylation |
13/49 |
313/18903 |
8.44E-13 |
5.09E-11 |
1.81E-11 |
TNF/IL6/AKT1/EGFR/SRC/PTGS2/MAPK1/PIK3CA/HGF/MAPK8/MAPK14/SYK/CDK2 |
13 |
| BP |
GO:0022409 |
positive regulation of cell-cell adhesion |
13/49 |
322/18903 |
1.21E-12 |
7.14E-11 |
2.54E-11 |
TNF/IL6/AKT1/SRC/IGF1/RHOA/PIK3CA/JAK2/CCL5/SYK/LCK/SELE/JAK1 |
13 |
| BP |
GO:1901214 |
regulation of neuron death |
13/49 |
325/18903 |
1.36E-12 |
7.88E-11 |
2.80E-11 |
TNF/AKT1/CASP3/KDR/RHOA/PIK3CA/HRAS/JAK2/CCL5/SIRT1/HMOX1/CASP8/NR3C1 |
13 |
| BP |
GO:0018209 |
peptidyl-serine modification |
13/49 |
332/18903 |
1.78E-12 |
1.01E-10 |
3.59E-11 |
TNF/IL6/AKT1/EGFR/SRC/PTGS2/MAPK1/PIK3CA/HGF/MAPK8/MAPK14/SYK/CDK2 |
13 |
| BP |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
11/49 |
193/18903 |
1.96E-12 |
1.09E-10 |
3.88E-11 |
TNF/IL6/EGFR/SRC/IGF1/KIT/JAK2/CCL5/HGF/SYK/ACE |
11 |
| BP |
GO:0052548 |
regulation of endopeptidase activity |
14/49 |
428/18903 |
2.47E-12 |
1.35E-10 |
4.81E-11 |
TNF/GAPDH/AKT1/SRC/MMP9/PTGS2/RHOA/JAK2/HGF/SIRT1/SYK/CASP1/CASP8/LCK |
14 |
| BP |
GO:0046686 |
response to cadmium ion |
8/49 |
60/18903 |
2.58E-12 |
1.39E-10 |
4.94E-11 |
AKT1/EGFR/MMP9/MAPK3/MAPK1/KIT/MAPK8/HMOX1 |
8 |
| BP |
GO:0051384 |
response to glucocorticoid |
10/49 |
142/18903 |
2.66E-12 |
1.41E-10 |
4.99E-11 |
TNF/IL6/CASP3/PTGS2/RHOA/PIK3CA/JAK2/IGF1R/ACE/NR3C1 |
10 |
| BP |
GO:2001237 |
negative regulation of extrinsic apoptotic signaling pathway |
9/49 |
99/18903 |
3.53E-12 |
1.84E-10 |
6.52E-11 |
TNF/AKT1/SRC/IGF1/HGF/HMOX1/NOS3/AR/LGALS3 |
9 |
| BP |
GO:1903039 |
positive regulation of leukocyte cell-cell adhesion |
12/49 |
275/18903 |
4.04E-12 |
2.06E-10 |
7.33E-11 |
TNF/IL6/AKT1/SRC/IGF1/RHOA/PIK3CA/JAK2/CCL5/SYK/LCK/SELE |
12 |
| BP |
GO:0071276 |
cellular response to cadmium ion |
7/49 |
37/18903 |
4.88E-12 |
2.45E-10 |
8.70E-11 |
AKT1/EGFR/MMP9/MAPK3/MAPK1/MAPK8/HMOX1 |
7 |
| BP |
GO:0010631 |
epithelial cell migration |
13/49 |
366/18903 |
6.09E-12 |
3.01E-10 |
1.07E-10 |
TNF/AKT1/SRC/MMP9/PTGS2/KDR/RHOA/PIK3CA/KIT/ITGB1/SIRT1/HMOX1/NOS3 |
13 |
| BP |
GO:0090132 |
epithelium migration |
13/49 |
369/18903 |
6.74E-12 |
3.28E-10 |
1.16E-10 |
TNF/AKT1/SRC/MMP9/PTGS2/KDR/RHOA/PIK3CA/KIT/ITGB1/SIRT1/HMOX1/NOS3 |
13 |
| BP |
GO:0032103 |
positive regulation of response to external stimulus |
14/49 |
464/18903 |
7.31E-12 |
3.43E-10 |
1.22E-10 |
TNF/IL6/SRC/MAPK3/PTGS2/KDR/MAPK1/JAK2/CCL5/IGF1R/SYK/CASP1/ACE/PLAU |
14 |
| BP |
GO:0060193 |
positive regulation of lipase activity |
8/49 |
68/18903 |
7.35E-12 |
3.43E-10 |
1.22E-10 |
EGFR/ESR1/RHOA/KIT/HRAS/CCL5/SELE/FLT1 |
8 |
| BP |
GO:0043491 |
protein kinase B signaling |
11/49 |
218/18903 |
7.40E-12 |
3.43E-10 |
1.22E-10 |
TNF/AKT1/EGFR/SRC/IGF1/KDR/PIK3CA/ITGB1/CCL5/SIRT1/IGF1R |
11 |
| BP |
GO:0090130 |
tissue migration |
13/49 |
374/18903 |
7.98E-12 |
3.64E-10 |
1.29E-10 |
TNF/AKT1/SRC/MMP9/PTGS2/KDR/RHOA/PIK3CA/KIT/ITGB1/SIRT1/HMOX1/NOS3 |
13 |
| BP |
GO:0061180 |
mammary gland epithelium development |
8/49 |
69/18903 |
8.30E-12 |
3.73E-10 |
1.33E-10 |
AKT1/SRC/ESR1/MAPK1/JAK2/PGR/NR3C1/AR |
8 |
| BP |
GO:0031667 |
response to nutrient levels |
14/49 |
474/18903 |
9.72E-12 |
4.31E-10 |
1.53E-10 |
TNF/AKT1/SRC/MAPK3/PTGS2/STAT1/MAPK1/MAPK8/SIRT1/IGF1R/MPO/MAPK14/HMOX1/ACE |
14 |
| BP |
GO:0097191 |
extrinsic apoptotic signaling pathway |
11/49 |
224/18903 |
9.93E-12 |
4.34E-10 |
1.54E-10 |
TNF/AKT1/SRC/IGF1/JAK2/HGF/HMOX1/CASP8/NOS3/AR/LGALS3 |
11 |
| BP |
GO:0097193 |
intrinsic apoptotic signaling pathway |
12/49 |
298/18903 |
1.04E-11 |
4.46E-10 |
1.58E-10 |
TNF/AKT1/SRC/MMP9/CASP3/PTGS2/HRAS/JAK2/MDM2/SIRT1/HMOX1/LCK |
12 |
| BP |
GO:0045785 |
positive regulation of cell adhesion |
14/49 |
484/18903 |
1.28E-11 |
5.45E-10 |
1.93E-10 |
TNF/IL6/AKT1/SRC/IGF1/KDR/RHOA/PIK3CA/JAK2/CCL5/SYK/LCK/SELE/JAK1 |
14 |
| BP |
GO:0150076 |
neuroinflammatory response |
8/49 |
73/18903 |
1.32E-11 |
5.54E-10 |
1.97E-10 |
TNF/IL6/MMP9/PTGS2/IGF1/JAK2/ITGB1/MMP3 |
8 |
| BP |
GO:0019221 |
cytokine-mediated signaling pathway |
14/49 |
496/18903 |
1.78E-11 |
7.35E-10 |
2.61E-10 |
TNF/IL6/AKT1/SRC/MAPK3/STAT1/KIT/JAK2/CCL5/SIRT1/SYK/CASP1/CASP8/JAK1 |
14 |
| BP |
GO:0022612 |
gland morphogenesis |
9/49 |
123/18903 |
2.57E-11 |
1.04E-09 |
3.71E-10 |
TNF/IL6/EGFR/SRC/ESR1/HGF/PGR/NR3C1/AR |
9 |
| BP |
GO:0050730 |
regulation of peptidyl-tyrosine phosphorylation |
11/49 |
266/18903 |
6.33E-11 |
2.54E-09 |
9.02E-10 |
TNF/IL6/EGFR/SRC/IGF1/KIT/JAK2/CCL5/HGF/SYK/ACE |
11 |
| BP |
GO:0060191 |
regulation of lipase activity |
8/49 |
90/18903 |
7.39E-11 |
2.93E-09 |
1.04E-09 |
EGFR/ESR1/RHOA/KIT/HRAS/CCL5/SELE/FLT1 |
8 |
| BP |
GO:0010518 |
positive regulation of phospholipase activity |
7/49 |
55/18903 |
9.29E-11 |
3.63E-09 |
1.29E-09 |
EGFR/ESR1/KIT/HRAS/CCL5/SELE/FLT1 |
7 |
| BP |
GO:0071383 |
cellular response to steroid hormone stimulus |
10/49 |
209/18903 |
1.24E-10 |
4.80E-09 |
1.70E-09 |
SRC/ESR1/RHOA/JAK2/SIRT1/IGF1R/ACE/PGR/NR3C1/AR |
10 |
| BP |
GO:0009411 |
response to UV |
9/49 |
149/18903 |
1.45E-10 |
5.52E-09 |
1.96E-09 |
AKT1/EGFR/MMP9/CASP3/PTGS2/MAPK8/SIRT1/MMP3/MMP1 |
9 |
| BP |
GO:0050863 |
regulation of T cell activation |
12/49 |
376/18903 |
1.53E-10 |
5.77E-09 |
2.05E-09 |
IL6/AKT1/SRC/CASP3/IGF1/RHOA/PIK3CA/JAK2/CCL5/SYK/LCK/LGALS3 |
12 |
| BP |
GO:0070141 |
response to UV-A |
5/49 |
14/18903 |
1.87E-10 |
6.94E-09 |
2.46E-09 |
AKT1/EGFR/MMP9/MMP3/MMP1 |
5 |
| BP |
GO:2001236 |
regulation of extrinsic apoptotic signaling pathway |
9/49 |
155/18903 |
2.06E-10 |
7.57E-09 |
2.69E-09 |
TNF/AKT1/SRC/IGF1/HGF/HMOX1/NOS3/AR/LGALS3 |
9 |
| BP |
GO:0051054 |
positive regulation of DNA metabolic process |
11/49 |
301/18903 |
2.37E-10 |
8.59E-09 |
3.05E-09 |
TNF/IL6/AKT1/EGFR/SRC/MAPK3/MAPK1/HGF/SIRT1/IGF1R/CDK2 |
11 |
| BP |
GO:0001667 |
ameboidal-type cell migration |
13/49 |
492/18903 |
2.40E-10 |
8.61E-09 |
3.06E-09 |
TNF/AKT1/SRC/MMP9/PTGS2/KDR/RHOA/PIK3CA/KIT/ITGB1/SIRT1/HMOX1/NOS3 |
13 |
| BP |
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
7/49 |
63/18903 |
2.49E-10 |
8.84E-09 |
3.14E-09 |
TNF/AKT1/MAPK3/MAPK1/CCL5/MAPK14/NOS3 |
7 |
| BP |
GO:0007596 |
blood coagulation |
10/49 |
225/18903 |
2.56E-10 |
8.84E-09 |
3.14E-09 |
IL6/SRC/ANXA5/PIK3CA/JAK2/MAPK14/SYK/LCK/NOS3/PLAU |
10 |
| BP |
GO:0008585 |
female gonad development |
8/49 |
105/18903 |
2.58E-10 |
8.84E-09 |
3.14E-09 |
SRC/CASP3/ESR1/KDR/KIT/SIRT1/PGR/NOS3 |
8 |
| BP |
GO:1901655 |
cellular response to ketone |
8/49 |
105/18903 |
2.58E-10 |
8.84E-09 |
3.14E-09 |
AKT1/SRC/JAK2/SIRT1/IGF1R/ACE/NR3C1/AR |
8 |
| BP |
GO:0016241 |
regulation of macroautophagy |
9/49 |
160/18903 |
2.74E-10 |
9.26E-09 |
3.29E-09 |
GAPDH/AKT1/CASP3/MAPK3/KDR/PIK3CA/MAPK8/SIRT1/HMOX1 |
9 |
| BP |
GO:0044089 |
positive regulation of cellular component biogenesis |
13/49 |
498/18903 |
2.79E-10 |
9.32E-09 |
3.31E-09 |
TNF/SRC/ESR1/KDR/RHOA/PIK3CA/KIT/HRAS/SYK/MMP3/CDK2/MMP1/LGALS3 |
13 |
| BP |
GO:0071241 |
cellular response to inorganic substance |
10/49 |
229/18903 |
3.04E-10 |
9.96E-09 |
3.53E-09 |
AKT1/EGFR/MMP9/MAPK3/PTGS2/MAPK1/MAPK8/HMOX1/MMP3/CDK2 |
10 |
| BP |
GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
10/49 |
229/18903 |
3.04E-10 |
9.96E-09 |
3.53E-09 |
TNF/AKT1/EGFR/SRC/RHOA/KIT/HRAS/SIRT1/SYK/FLT1 |
10 |
| BP |
GO:0036293 |
response to decreased oxygen levels |
11/49 |
309/18903 |
3.13E-10 |
1.01E-08 |
3.60E-09 |
TNF/AKT1/SRC/CASP3/PTGS2/RHOA/MDM2/SIRT1/HMOX1/ACE/PLAU |
11 |
| BP |
GO:0050817 |
coagulation |
10/49 |
230/18903 |
3.17E-10 |
1.02E-08 |
3.61E-09 |
IL6/SRC/ANXA5/PIK3CA/JAK2/MAPK14/SYK/LCK/NOS3/PLAU |
10 |
| BP |
GO:0002685 |
regulation of leukocyte migration |
10/49 |
231/18903 |
3.31E-10 |
1.04E-08 |
3.69E-09 |
TNF/IL6/AKT1/MAPK3/MAPK1/RHOA/CCL5/HMOX1/SELE/LGALS3 |
10 |
| BP |
GO:0007599 |
hemostasis |
10/49 |
231/18903 |
3.31E-10 |
1.04E-08 |
3.69E-09 |
IL6/SRC/ANXA5/PIK3CA/JAK2/MAPK14/SYK/LCK/NOS3/PLAU |
10 |
| BP |
GO:0010517 |
regulation of phospholipase activity |
7/49 |
66/18903 |
3.49E-10 |
1.07E-08 |
3.81E-09 |
EGFR/ESR1/KIT/HRAS/CCL5/SELE/FLT1 |
7 |
| BP |
GO:0046545 |
development of primary female sexual characteristics |
8/49 |
109/18903 |
3.49E-10 |
1.07E-08 |
3.81E-09 |
SRC/CASP3/ESR1/KDR/KIT/SIRT1/PGR/NOS3 |
8 |
| BP |
GO:0008406 |
gonad development |
10/49 |
233/18903 |
3.60E-10 |
1.10E-08 |
3.89E-09 |
SRC/CASP3/ESR1/KDR/KIT/SIRT1/ACE/PGR/NOS3/AR |
10 |
| BP |
GO:0045137 |
development of primary sexual characteristics |
10/49 |
238/18903 |
4.43E-10 |
1.33E-08 |
4.74E-09 |
SRC/CASP3/ESR1/KDR/KIT/SIRT1/ACE/PGR/NOS3/AR |
10 |
| BP |
GO:0050678 |
regulation of epithelial cell proliferation |
12/49 |
414/18903 |
4.61E-10 |
1.38E-08 |
4.88E-09 |
TNF/AKT1/EGFR/IGF1/KDR/STAT1/HRAS/SIRT1/HMOX1/PGR/FLT1/AR |
12 |
| BP |
GO:0009416 |
response to light stimulus |
11/49 |
321/18903 |
4.68E-10 |
1.38E-08 |
4.91E-09 |
AKT1/EGFR/MMP9/CASP3/PTGS2/KIT/ITGB1/MAPK8/SIRT1/MMP3/MMP1 |
11 |
| BP |
GO:0030518 |
intracellular steroid hormone receptor signaling pathway |
8/49 |
116/18903 |
5.76E-10 |
1.68E-08 |
5.98E-09 |
SRC/ESR1/RHOA/JAK2/SIRT1/PGR/NR3C1/AR |
8 |
| BP |
GO:0031098 |
stress-activated protein kinase signaling cascade |
10/49 |
246/18903 |
6.11E-10 |
1.77E-08 |
6.28E-09 |
TNF/EGFR/MAPK3/MAPK1/RHOA/HRAS/HGF/MAPK8/IGF1R/MAPK14 |
10 |
| BP |
GO:0042698 |
ovulation cycle |
7/49 |
72/18903 |
6.52E-10 |
1.87E-08 |
6.64E-09 |
SRC/CASP3/ESR1/SIRT1/IGF1R/PGR/NOS3 |
7 |
| BP |
GO:0043534 |
blood vessel endothelial cell migration |
9/49 |
177/18903 |
6.72E-10 |
1.91E-08 |
6.78E-09 |
TNF/AKT1/PTGS2/KDR/RHOA/ITGB1/SIRT1/HMOX1/NOS3 |
9 |
| BP |
GO:0001503 |
ossification |
12/49 |
429/18903 |
6.92E-10 |
1.95E-08 |
6.91E-09 |
TNF/IL6/AKT1/EGFR/MMP9/MAPK3/PTGS2/IGF1/MAPK1/RHOA/HGF/MAPK14 |
12 |
| BP |
GO:0050870 |
positive regulation of T cell activation |
10/49 |
251/18903 |
7.43E-10 |
2.07E-08 |
7.36E-09 |
IL6/AKT1/SRC/IGF1/RHOA/PIK3CA/JAK2/CCL5/SYK/LCK |
10 |
| BP |
GO:0070482 |
response to oxygen levels |
11/49 |
337/18903 |
7.82E-10 |
2.16E-08 |
7.68E-09 |
TNF/AKT1/SRC/CASP3/PTGS2/RHOA/MDM2/SIRT1/HMOX1/ACE/PLAU |
11 |
| BP |
GO:0010863 |
positive regulation of phospholipase C activity |
6/49 |
40/18903 |
7.93E-10 |
2.17E-08 |
7.71E-09 |
EGFR/ESR1/KIT/HRAS/SELE/FLT1 |
6 |
| BP |
GO:0051402 |
neuron apoptotic process |
10/49 |
255/18903 |
8.66E-10 |
2.35E-08 |
8.35E-09 |
TNF/GAPDH/CASP3/KDR/RHOA/PIK3CA/HRAS/JAK2/HMOX1/NR3C1 |
10 |
| BP |
GO:0150077 |
regulation of neuroinflammatory response |
6/49 |
41/18903 |
9.27E-10 |
2.50E-08 |
8.86E-09 |
TNF/IL6/MMP9/PTGS2/IGF1/MMP3 |
6 |
| BP |
GO:0046660 |
female sex differentiation |
8/49 |
124/18903 |
9.83E-10 |
2.62E-08 |
9.30E-09 |
SRC/CASP3/ESR1/KDR/KIT/SIRT1/PGR/NOS3 |
8 |
| BP |
GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
8/49 |
125/18903 |
1.05E-09 |
2.77E-08 |
9.83E-09 |
TNF/RHOA/JAK2/SIRT1/SYK/CASP1/CASP8/LCK |
8 |
| BP |
GO:1900274 |
regulation of phospholipase C activity |
6/49 |
42/18903 |
1.08E-09 |
2.83E-08 |
1.00E-08 |
EGFR/ESR1/KIT/HRAS/SELE/FLT1 |
6 |
| BP |
GO:0070661 |
leukocyte proliferation |
11/49 |
348/18903 |
1.10E-09 |
2.85E-08 |
1.01E-08 |
IL6/CASP3/MAPK3/IGF1/MAPK1/KIT/JAK2/CCL5/SYK/ACE/LGALS3 |
11 |
| BP |
GO:0045765 |
regulation of angiogenesis |
11/49 |
349/18903 |
1.13E-09 |
2.91E-08 |
1.03E-08 |
TNF/IL6/KDR/STAT1/ITGB1/HGF/SIRT1/HMOX1/NOS3/FLT1/JAK1 |
11 |
| BP |
GO:0006006 |
glucose metabolic process |
9/49 |
188/18903 |
1.15E-09 |
2.93E-08 |
1.04E-08 |
TNF/GAPDH/AKT1/SRC/IGF1/PIK3CA/SIRT1/MAPK14/NR3C1 |
9 |
| BP |
GO:1903829 |
positive regulation of protein localization |
12/49 |
451/18903 |
1.22E-09 |
3.09E-08 |
1.10E-08 |
TNF/AKT1/EGFR/SRC/PTGS2/IGF1/HRAS/JAK2/ITGB1/MAPK8/MAPK14/LGALS3 |
12 |
| BP |
GO:0051090 |
regulation of DNA-binding transcription factor activity |
12/49 |
454/18903 |
1.31E-09 |
3.30E-08 |
1.17E-08 |
TNF/IL6/AKT1/MAPK3/ESR1/KIT/JAK2/MAPK8/SIRT1/SYK/HMOX1/AR |
12 |
| BP |
GO:1901342 |
regulation of vasculature development |
11/49 |
355/18903 |
1.35E-09 |
3.37E-08 |
1.20E-08 |
TNF/IL6/KDR/STAT1/ITGB1/HGF/SIRT1/HMOX1/NOS3/FLT1/JAK1 |
11 |
| BP |
GO:0070663 |
regulation of leukocyte proliferation |
10/49 |
269/18903 |
1.45E-09 |
3.59E-08 |
1.27E-08 |
IL6/CASP3/MAPK3/IGF1/MAPK1/KIT/JAK2/CCL5/SYK/LGALS3 |
10 |
| BP |
GO:0010038 |
response to metal ion |
11/49 |
360/18903 |
1.57E-09 |
3.84E-08 |
1.36E-08 |
AKT1/EGFR/MMP9/CASP3/MAPK3/PTGS2/MAPK1/KIT/MAPK8/HMOX1/CASP8 |
11 |
| BP |
GO:0030168 |
platelet activation |
8/49 |
133/18903 |
1.72E-09 |
4.18E-08 |
1.48E-08 |
IL6/SRC/PIK3CA/JAK2/MAPK14/SYK/LCK/NOS3 |
8 |
| BP |
GO:0043401 |
steroid hormone mediated signaling pathway |
8/49 |
136/18903 |
2.05E-09 |
4.95E-08 |
1.76E-08 |
SRC/ESR1/RHOA/JAK2/SIRT1/PGR/NR3C1/AR |
8 |
| BP |
GO:1904019 |
epithelial cell apoptotic process |
8/49 |
137/18903 |
2.18E-09 |
5.20E-08 |
1.85E-08 |
TNF/IL6/CASP3/ESR1/KDR/JAK2/IGF1R/HMOX1 |
8 |
| BP |
GO:0045862 |
positive regulation of proteolysis |
11/49 |
372/18903 |
2.21E-09 |
5.21E-08 |
1.85E-08 |
TNF/AKT1/SRC/RHOA/JAK2/MDM2/SIRT1/SYK/CASP1/CASP8/LCK |
11 |
| BP |
GO:0043542 |
endothelial cell migration |
10/49 |
281/18903 |
2.21E-09 |
5.21E-08 |
1.85E-08 |
TNF/AKT1/PTGS2/KDR/RHOA/PIK3CA/ITGB1/SIRT1/HMOX1/NOS3 |
10 |
| BP |
GO:0051346 |
negative regulation of hydrolase activity |
11/49 |
373/18903 |
2.27E-09 |
5.26E-08 |
1.87E-08 |
TNF/GAPDH/AKT1/SRC/MMP9/PTGS2/HRAS/HGF/CTSB/NOS3/LGALS3 |
11 |
| BP |
GO:1901653 |
cellular response to peptide |
11/49 |
373/18903 |
2.27E-09 |
5.26E-08 |
1.87E-08 |
TNF/AKT1/SRC/IGF1/STAT1/PIK3CA/JAK2/MDM2/SIRT1/IGF1R/JAK1 |
11 |
| BP |
GO:0030879 |
mammary gland development |
8/49 |
138/18903 |
2.30E-09 |
5.28E-08 |
1.88E-08 |
AKT1/SRC/ESR1/MAPK1/JAK2/PGR/NR3C1/AR |
8 |
| BP |
GO:0007260 |
tyrosine phosphorylation of STAT protein |
7/49 |
86/18903 |
2.32E-09 |
5.28E-08 |
1.88E-08 |
TNF/IL6/IGF1/KIT/JAK2/CCL5/JAK1 |
7 |
| BP |
GO:1901654 |
response to ketone |
9/49 |
205/18903 |
2.46E-09 |
5.57E-08 |
1.98E-08 |
AKT1/SRC/PIK3CA/JAK2/SIRT1/IGF1R/ACE/NR3C1/AR |
9 |
| BP |
GO:0071674 |
mononuclear cell migration |
9/49 |
206/18903 |
2.56E-09 |
5.77E-08 |
2.05E-08 |
TNF/IL6/AKT1/MAPK3/MAPK1/RHOA/CCL5/FLT1/LGALS3 |
9 |
| BP |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
10/49 |
288/18903 |
2.81E-09 |
6.22E-08 |
2.21E-08 |
TNF/GAPDH/AKT1/ESR1/STAT1/RHOA/SIRT1/CASP1/HMOX1/CASP8 |
10 |
| BP |
GO:0007548 |
sex differentiation |
10/49 |
288/18903 |
2.81E-09 |
6.22E-08 |
2.21E-08 |
SRC/CASP3/ESR1/KDR/KIT/SIRT1/ACE/PGR/NOS3/AR |
10 |
| BP |
GO:2001056 |
positive regulation of cysteine-type endopeptidase activity |
8/49 |
143/18903 |
3.06E-09 |
6.72E-08 |
2.39E-08 |
TNF/RHOA/JAK2/SIRT1/SYK/CASP1/CASP8/LCK |
8 |
| BP |
GO:0010632 |
regulation of epithelial cell migration |
10/49 |
292/18903 |
3.20E-09 |
6.99E-08 |
2.48E-08 |
TNF/AKT1/SRC/MMP9/PTGS2/KDR/RHOA/SIRT1/HMOX1/NOS3 |
10 |
| BP |
GO:0022602 |
ovulation cycle process |
6/49 |
51/18903 |
3.64E-09 |
7.85E-08 |
2.79E-08 |
SRC/CASP3/ESR1/SIRT1/PGR/NOS3 |
6 |
| BP |
GO:0001666 |
response to hypoxia |
10/49 |
296/18903 |
3.65E-09 |
7.85E-08 |
2.79E-08 |
TNF/SRC/CASP3/PTGS2/RHOA/MDM2/SIRT1/HMOX1/ACE/PLAU |
10 |
| BP |
GO:1904705 |
regulation of vascular associated smooth muscle cell proliferation |
7/49 |
93/18903 |
4.03E-09 |
8.60E-08 |
3.05E-08 |
TNF/SRC/MMP9/IGF1/RHOA/JAK2/HMOX1 |
7 |
| BP |
GO:0071900 |
regulation of protein serine/threonine kinase activity |
11/49 |
395/18903 |
4.13E-09 |
8.75E-08 |
3.11E-08 |
TNF/AKT1/EGFR/SRC/CASP3/RHOA/KIT/HRAS/SIRT1/SYK/FLT1 |
11 |
| BP |
GO:0043523 |
regulation of neuron apoptotic process |
9/49 |
218/18903 |
4.21E-09 |
8.88E-08 |
3.15E-08 |
TNF/CASP3/KDR/RHOA/PIK3CA/HRAS/JAK2/HMOX1/NR3C1 |
9 |
| BP |
GO:0043535 |
regulation of blood vessel endothelial cell migration |
8/49 |
150/18903 |
4.46E-09 |
9.34E-08 |
3.31E-08 |
TNF/AKT1/PTGS2/KDR/RHOA/SIRT1/HMOX1/NOS3 |
8 |
| BP |
GO:1990874 |
vascular associated smooth muscle cell proliferation |
7/49 |
95/18903 |
4.68E-09 |
9.72E-08 |
3.45E-08 |
TNF/SRC/MMP9/IGF1/RHOA/JAK2/HMOX1 |
7 |
| BP |
GO:0048608 |
reproductive structure development |
10/49 |
306/18903 |
5.02E-09 |
1.04E-07 |
3.68E-08 |
SRC/CASP3/ESR1/KDR/KIT/SIRT1/ACE/PGR/NOS3/AR |
10 |
| BP |
GO:0031349 |
positive regulation of defense response |
10/49 |
307/18903 |
5.18E-09 |
1.06E-07 |
3.77E-08 |
TNF/IL6/SRC/MAPK3/PTGS2/JAK2/CCL5/SYK/CASP1/ACE |
10 |
| BP |
GO:0050679 |
positive regulation of epithelial cell proliferation |
9/49 |
224/18903 |
5.34E-09 |
1.09E-07 |
3.86E-08 |
TNF/AKT1/EGFR/IGF1/KDR/HRAS/SIRT1/HMOX1/AR |
9 |
| BP |
GO:0061458 |
reproductive system development |
10/49 |
310/18903 |
5.68E-09 |
1.15E-07 |
4.08E-08 |
SRC/CASP3/ESR1/KDR/KIT/SIRT1/ACE/PGR/NOS3/AR |
10 |
| BP |
GO:0019318 |
hexose metabolic process |
9/49 |
229/18903 |
6.48E-09 |
1.30E-07 |
4.62E-08 |
TNF/GAPDH/AKT1/SRC/IGF1/PIK3CA/SIRT1/MAPK14/NR3C1 |
9 |
| BP |
GO:0016236 |
macroautophagy |
10/49 |
317/18903 |
7.03E-09 |
1.40E-07 |
4.98E-08 |
GAPDH/AKT1/SRC/CASP3/MAPK3/KDR/PIK3CA/MAPK8/SIRT1/HMOX1 |
10 |
| BP |
GO:1905477 |
positive regulation of protein localization to membrane |
7/49 |
101/18903 |
7.20E-09 |
1.43E-07 |
5.06E-08 |
TNF/AKT1/EGFR/HRAS/ITGB1/MAPK8/LGALS3 |
7 |
| BP |
GO:0060326 |
cell chemotaxis |
10/49 |
319/18903 |
7.47E-09 |
1.47E-07 |
5.22E-08 |
IL6/MAPK3/KDR/MAPK1/KIT/CCL5/HGF/SYK/FLT1/LGALS3 |
10 |
| BP |
GO:0051403 |
stress-activated MAPK cascade |
9/49 |
239/18903 |
9.40E-09 |
1.84E-07 |
6.53E-08 |
TNF/EGFR/MAPK3/MAPK1/HRAS/HGF/MAPK8/IGF1R/MAPK14 |
9 |
| BP |
GO:0070665 |
positive regulation of leukocyte proliferation |
8/49 |
167/18903 |
1.04E-08 |
2.02E-07 |
7.17E-08 |
IL6/MAPK3/IGF1/MAPK1/KIT/JAK2/CCL5/SYK |
8 |
| BP |
GO:0060135 |
maternal process involved in female pregnancy |
6/49 |
61/18903 |
1.10E-08 |
2.13E-07 |
7.55E-08 |
AKT1/PTGS2/ESR1/PGR/CTSB/AR |
6 |
| BP |
GO:0005996 |
monosaccharide metabolic process |
9/49 |
248/18903 |
1.30E-08 |
2.47E-07 |
8.76E-08 |
TNF/GAPDH/AKT1/SRC/IGF1/PIK3CA/SIRT1/MAPK14/NR3C1 |
9 |
| BP |
GO:1904035 |
regulation of epithelial cell apoptotic process |
7/49 |
110/18903 |
1.31E-08 |
2.47E-07 |
8.76E-08 |
TNF/IL6/ESR1/KDR/JAK2/IGF1R/HMOX1 |
7 |
| BP |
GO:0007259 |
receptor signaling pathway via JAK-STAT |
8/49 |
172/18903 |
1.31E-08 |
2.47E-07 |
8.76E-08 |
TNF/IL6/IGF1/STAT1/KIT/JAK2/CCL5/JAK1 |
8 |
| BP |
GO:1905475 |
regulation of protein localization to membrane |
8/49 |
172/18903 |
1.31E-08 |
2.47E-07 |
8.76E-08 |
TNF/AKT1/EGFR/HRAS/ITGB1/MAPK8/AR/LGALS3 |
8 |
| BP |
GO:0070371 |
ERK1 and ERK2 cascade |
10/49 |
340/18903 |
1.37E-08 |
2.56E-07 |
9.10E-08 |
TNF/EGFR/SRC/MAPK3/IGF1/KDR/MAPK1/HRAS/CCL5/SYK |
10 |
| BP |
GO:0010950 |
positive regulation of endopeptidase activity |
8/49 |
174/18903 |
1.43E-08 |
2.67E-07 |
9.47E-08 |
TNF/RHOA/JAK2/SIRT1/SYK/CASP1/CASP8/LCK |
8 |
| BP |
GO:0010506 |
regulation of autophagy |
10/49 |
344/18903 |
1.53E-08 |
2.82E-07 |
9.99E-08 |
GAPDH/AKT1/CASP3/MAPK3/KDR/PIK3CA/HGF/MAPK8/SIRT1/HMOX1 |
10 |
| BP |
GO:0060603 |
mammary gland duct morphogenesis |
5/49 |
31/18903 |
1.53E-08 |
2.82E-07 |
9.99E-08 |
SRC/ESR1/PGR/NR3C1/AR |
5 |
| BP |
GO:0010634 |
positive regulation of epithelial cell migration |
8/49 |
176/18903 |
1.57E-08 |
2.86E-07 |
1.02E-07 |
AKT1/SRC/MMP9/PTGS2/KDR/SIRT1/HMOX1/NOS3 |
8 |
| BP |
GO:0002696 |
positive regulation of leukocyte activation |
11/49 |
450/18903 |
1.59E-08 |
2.88E-07 |
1.02E-07 |
TNF/IL6/AKT1/SRC/IGF1/RHOA/PIK3CA/JAK2/CCL5/SYK/LCK |
11 |
| BP |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
9/49 |
255/18903 |
1.65E-08 |
2.97E-07 |
1.06E-07 |
TNF/GAPDH/ESR1/STAT1/RHOA/SIRT1/CASP1/HMOX1/CASP8 |
9 |
| BP |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
6/49 |
67/18903 |
1.96E-08 |
3.51E-07 |
1.25E-07 |
TNF/IL6/IGF1/KIT/JAK2/CCL5 |
6 |
| BP |
GO:0043406 |
positive regulation of MAP kinase activity |
7/49 |
117/18903 |
2.01E-08 |
3.59E-07 |
1.27E-07 |
TNF/EGFR/SRC/KIT/HRAS/SYK/FLT1 |
7 |
| BP |
GO:0097696 |
receptor signaling pathway via STAT |
8/49 |
183/18903 |
2.13E-08 |
3.76E-07 |
1.33E-07 |
TNF/IL6/IGF1/STAT1/KIT/JAK2/CCL5/JAK1 |
8 |
| BP |
GO:0071346 |
cellular response to interferon-gamma |
7/49 |
118/18903 |
2.13E-08 |
3.76E-07 |
1.33E-07 |
TNF/GAPDH/STAT1/JAK2/CCL5/CASP1/JAK1 |
7 |
| BP |
GO:0050867 |
positive regulation of cell activation |
11/49 |
467/18903 |
2.32E-08 |
4.07E-07 |
1.45E-07 |
TNF/IL6/AKT1/SRC/IGF1/RHOA/PIK3CA/JAK2/CCL5/SYK/LCK |
11 |
| BP |
GO:0051897 |
positive regulation of protein kinase B signaling |
7/49 |
120/18903 |
2.40E-08 |
4.18E-07 |
1.48E-07 |
TNF/EGFR/SRC/IGF1/PIK3CA/ITGB1/IGF1R |
7 |
| BP |
GO:0034405 |
response to fluid shear stress |
5/49 |
34/18903 |
2.49E-08 |
4.31E-07 |
1.53E-07 |
AKT1/SRC/PTGS2/ACE/NOS3 |
5 |
| BP |
GO:0045766 |
positive regulation of angiogenesis |
8/49 |
187/18903 |
2.52E-08 |
4.31E-07 |
1.53E-07 |
KDR/ITGB1/HGF/SIRT1/HMOX1/NOS3/FLT1/JAK1 |
8 |
| BP |
GO:1904018 |
positive regulation of vasculature development |
8/49 |
187/18903 |
2.52E-08 |
4.31E-07 |
1.53E-07 |
KDR/ITGB1/HGF/SIRT1/HMOX1/NOS3/FLT1/JAK1 |
8 |
| BP |
GO:0007565 |
female pregnancy |
8/49 |
189/18903 |
2.74E-08 |
4.60E-07 |
1.63E-07 |
AKT1/MMP9/PTGS2/ESR1/ACE/PGR/CTSB/AR |
8 |
| BP |
GO:0051896 |
regulation of protein kinase B signaling |
8/49 |
189/18903 |
2.74E-08 |
4.60E-07 |
1.63E-07 |
TNF/EGFR/SRC/IGF1/PIK3CA/ITGB1/SIRT1/IGF1R |
8 |
| BP |
GO:0071478 |
cellular response to radiation |
8/49 |
189/18903 |
2.74E-08 |
4.60E-07 |
1.63E-07 |
MMP9/PTGS2/HRAS/MDM2/SIRT1/MAPK14/MMP3/MMP1 |
8 |
| BP |
GO:0071675 |
regulation of mononuclear cell migration |
7/49 |
123/18903 |
2.85E-08 |
4.77E-07 |
1.69E-07 |
TNF/AKT1/MAPK3/MAPK1/RHOA/CCL5/LGALS3 |
7 |
| BP |
GO:0009755 |
hormone-mediated signaling pathway |
8/49 |
192/18903 |
3.09E-08 |
5.09E-07 |
1.81E-07 |
SRC/ESR1/RHOA/JAK2/SIRT1/PGR/NR3C1/AR |
8 |
| BP |
GO:0031099 |
regeneration |
8/49 |
192/18903 |
3.09E-08 |
5.09E-07 |
1.81E-07 |
TNF/IL6/IGF1/JAK2/HGF/IGF1R/HMOX1/ACE |
8 |
| BP |
GO:0031334 |
positive regulation of protein-containing complex assembly |
8/49 |
192/18903 |
3.09E-08 |
5.09E-07 |
1.81E-07 |
TNF/SRC/ESR1/RHOA/SYK/MMP3/MMP1/LGALS3 |
8 |
| BP |
GO:1904375 |
regulation of protein localization to cell periphery |
7/49 |
125/18903 |
3.18E-08 |
5.21E-07 |
1.85E-07 |
TNF/AKT1/EGFR/HRAS/ITGB1/AR/LGALS3 |
7 |
| BP |
GO:0071260 |
cellular response to mechanical stimulus |
6/49 |
73/18903 |
3.30E-08 |
5.37E-07 |
1.91E-07 |
MAPK3/PTGS2/MAPK8/IGF1R/CASP1/CASP8 |
6 |
| BP |
GO:0010952 |
positive regulation of peptidase activity |
8/49 |
194/18903 |
3.35E-08 |
5.43E-07 |
1.93E-07 |
TNF/RHOA/JAK2/SIRT1/SYK/CASP1/CASP8/LCK |
8 |
| BP |
GO:0034110 |
regulation of homotypic cell-cell adhesion |
5/49 |
37/18903 |
3.89E-08 |
6.23E-07 |
2.21E-07 |
IL6/JAK2/CCL5/SYK/JAK1 |
5 |
| BP |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
6/49 |
75/18903 |
3.89E-08 |
6.23E-07 |
2.21E-07 |
AKT1/PTGS2/KDR/SIRT1/HMOX1/NOS3 |
6 |
| BP |
GO:0071248 |
cellular response to metal ion |
8/49 |
198/18903 |
3.93E-08 |
6.26E-07 |
2.22E-07 |
AKT1/EGFR/MMP9/MAPK3/PTGS2/MAPK1/MAPK8/HMOX1 |
8 |
| BP |
GO:0042542 |
response to hydrogen peroxide |
7/49 |
130/18903 |
4.18E-08 |
6.62E-07 |
2.35E-07 |
IL6/SRC/CASP3/STAT1/HGF/SIRT1/HMOX1 |
7 |
| BP |
GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
6/49 |
78/18903 |
4.93E-08 |
7.78E-07 |
2.76E-07 |
TNF/AKT1/SRC/MMP9/PTGS2/HGF |
6 |
| BP |
GO:0050878 |
regulation of body fluid levels |
10/49 |
390/18903 |
5.00E-08 |
7.84E-07 |
2.78E-07 |
IL6/SRC/ANXA5/PIK3CA/JAK2/MAPK14/SYK/LCK/NOS3/PLAU |
10 |
| BP |
GO:0048872 |
homeostasis of number of cells |
9/49 |
296/18903 |
5.95E-08 |
9.27E-07 |
3.29E-07 |
IL6/AKT1/CASP3/STAT1/KIT/JAK2/MAPK14/HMOX1/NOS3 |
9 |
| BP |
GO:0044703 |
multi-organism reproductive process |
8/49 |
209/18903 |
5.97E-08 |
9.27E-07 |
3.29E-07 |
AKT1/MMP9/PTGS2/ESR1/ACE/PGR/CTSB/AR |
8 |
| BP |
GO:0051251 |
positive regulation of lymphocyte activation |
10/49 |
400/18903 |
6.33E-08 |
9.79E-07 |
3.47E-07 |
IL6/AKT1/SRC/IGF1/RHOA/PIK3CA/JAK2/CCL5/SYK/LCK |
10 |
| BP |
GO:0042509 |
regulation of tyrosine phosphorylation of STAT protein |
6/49 |
82/18903 |
6.67E-08 |
1.02E-06 |
3.64E-07 |
TNF/IL6/IGF1/KIT/JAK2/CCL5 |
6 |
| BP |
GO:0034341 |
response to interferon-gamma |
7/49 |
140/18903 |
6.97E-08 |
1.07E-06 |
3.78E-07 |
TNF/GAPDH/STAT1/JAK2/CCL5/CASP1/JAK1 |
7 |
| BP |
GO:0048511 |
rhythmic process |
9/49 |
302/18903 |
7.06E-08 |
1.07E-06 |
3.81E-07 |
TNF/SRC/CASP3/ESR1/MAPK8/SIRT1/IGF1R/PGR/NOS3 |
9 |
| BP |
GO:0034112 |
positive regulation of homotypic cell-cell adhesion |
4/49 |
16/18903 |
7.09E-08 |
1.07E-06 |
3.81E-07 |
IL6/JAK2/CCL5/JAK1 |
4 |
| BP |
GO:0030099 |
myeloid cell differentiation |
10/49 |
407/18903 |
7.45E-08 |
1.12E-06 |
3.98E-07 |
TNF/SRC/MMP9/CASP3/STAT1/KIT/JAK2/SIRT1/MAPK14/CASP8 |
10 |
| BP |
GO:0033135 |
regulation of peptidyl-serine phosphorylation |
7/49 |
143/18903 |
8.06E-08 |
1.21E-06 |
4.29E-07 |
TNF/IL6/AKT1/EGFR/PTGS2/PIK3CA/HGF |
7 |
| BP |
GO:0044706 |
multi-multicellular organism process |
8/49 |
218/18903 |
8.27E-08 |
1.22E-06 |
4.34E-07 |
AKT1/MMP9/PTGS2/ESR1/ACE/PGR/CTSB/AR |
8 |
| BP |
GO:1901215 |
negative regulation of neuron death |
8/49 |
218/18903 |
8.27E-08 |
1.22E-06 |
4.34E-07 |
AKT1/KDR/RHOA/PIK3CA/HRAS/JAK2/SIRT1/HMOX1 |
8 |
| BP |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
6/49 |
85/18903 |
8.28E-08 |
1.22E-06 |
4.34E-07 |
TNF/HGF/HMOX1/CASP8/NOS3/LGALS3 |
6 |
| BP |
GO:0071548 |
response to dexamethasone |
5/49 |
43/18903 |
8.48E-08 |
1.25E-06 |
4.42E-07 |
PIK3CA/JAK2/IGF1R/ACE/NR3C1 |
5 |
| BP |
GO:0014910 |
regulation of smooth muscle cell migration |
6/49 |
87/18903 |
9.52E-08 |
1.39E-06 |
4.94E-07 |
SRC/IGF1/RHOA/CCL5/ACE/PLAU |
6 |
| BP |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
8/49 |
223/18903 |
9.84E-08 |
1.43E-06 |
5.09E-07 |
TNF/EGFR/SRC/MAPK3/IGF1/KDR/HRAS/CCL5 |
8 |
| BP |
GO:0070372 |
regulation of ERK1 and ERK2 cascade |
9/49 |
315/18903 |
1.01E-07 |
1.46E-06 |
5.20E-07 |
TNF/EGFR/SRC/MAPK3/IGF1/KDR/HRAS/CCL5/SYK |
9 |
| BP |
GO:0002687 |
positive regulation of leukocyte migration |
7/49 |
148/18903 |
1.02E-07 |
1.46E-06 |
5.20E-07 |
TNF/IL6/MAPK3/MAPK1/RHOA/CCL5/LGALS3 |
7 |
| BP |
GO:0043434 |
response to peptide hormone |
10/49 |
421/18903 |
1.02E-07 |
1.46E-06 |
5.20E-07 |
AKT1/SRC/PTGS2/STAT1/PIK3CA/JAK2/SIRT1/IGF1R/MAPK14/JAK1 |
10 |
| BP |
GO:0030574 |
collagen catabolic process |
5/49 |
45/18903 |
1.07E-07 |
1.52E-06 |
5.41E-07 |
MMP9/ITGB1/CTSB/MMP3/MMP1 |
5 |
| BP |
GO:0046427 |
positive regulation of receptor signaling pathway via JAK-STAT |
5/49 |
45/18903 |
1.07E-07 |
1.52E-06 |
5.41E-07 |
TNF/IL6/KIT/JAK2/CCL5 |
5 |
| BP |
GO:0001890 |
placenta development |
7/49 |
150/18903 |
1.12E-07 |
1.58E-06 |
5.62E-07 |
AKT1/EGFR/PTGS2/MAPK1/MAPK14/CASP8/CTSB |
7 |
| BP |
GO:0060443 |
mammary gland morphogenesis |
5/49 |
46/18903 |
1.20E-07 |
1.69E-06 |
6.00E-07 |
SRC/ESR1/PGR/NR3C1/AR |
5 |
| BP |
GO:0062013 |
positive regulation of small molecule metabolic process |
7/49 |
152/18903 |
1.22E-07 |
1.72E-06 |
6.09E-07 |
TNF/AKT1/SRC/PTGS2/IGF1/SIRT1/NOS3 |
7 |
| BP |
GO:2000117 |
negative regulation of cysteine-type endopeptidase activity |
6/49 |
91/18903 |
1.25E-07 |
1.73E-06 |
6.15E-07 |
TNF/AKT1/SRC/MMP9/PTGS2/HGF |
6 |
| BP |
GO:0010594 |
regulation of endothelial cell migration |
8/49 |
230/18903 |
1.25E-07 |
1.73E-06 |
6.15E-07 |
TNF/AKT1/PTGS2/KDR/RHOA/SIRT1/HMOX1/NOS3 |
8 |
| BP |
GO:0045834 |
positive regulation of lipid metabolic process |
7/49 |
154/18903 |
1.34E-07 |
1.85E-06 |
6.55E-07 |
TNF/AKT1/SRC/PTGS2/KIT/IGF1R/FLT1 |
7 |
| BP |
GO:0046677 |
response to antibiotic |
5/49 |
47/18903 |
1.34E-07 |
1.85E-06 |
6.55E-07 |
CASP3/JAK2/MDM2/CASP8/JAK1 |
5 |
| BP |
GO:0071496 |
cellular response to external stimulus |
9/49 |
328/18903 |
1.43E-07 |
1.95E-06 |
6.93E-07 |
MAPK3/PTGS2/MAPK1/MAPK8/SIRT1/IGF1R/CASP1/HMOX1/CASP8 |
9 |
| BP |
GO:0002042 |
cell migration involved in sprouting angiogenesis |
6/49 |
94/18903 |
1.51E-07 |
2.06E-06 |
7.33E-07 |
AKT1/PTGS2/KDR/RHOA/ITGB1/HMOX1 |
6 |
| BP |
GO:0014909 |
smooth muscle cell migration |
6/49 |
95/18903 |
1.61E-07 |
2.19E-06 |
7.77E-07 |
SRC/IGF1/RHOA/CCL5/ACE/PLAU |
6 |
| BP |
GO:0035094 |
response to nicotine |
5/49 |
49/18903 |
1.66E-07 |
2.23E-06 |
7.93E-07 |
TNF/CASP3/MAPK1/IGF1R/HMOX1 |
5 |
| BP |
GO:1904894 |
positive regulation of receptor signaling pathway via STAT |
5/49 |
49/18903 |
1.66E-07 |
2.23E-06 |
7.93E-07 |
TNF/IL6/KIT/JAK2/CCL5 |
5 |
| BP |
GO:0060562 |
epithelial tube morphogenesis |
9/49 |
335/18903 |
1.71E-07 |
2.28E-06 |
8.11E-07 |
TNF/SRC/CASP3/ESR1/KDR/RHOA/PGR/NR3C1/AR |
9 |
| BP |
GO:0030595 |
leukocyte chemotaxis |
8/49 |
240/18903 |
1.73E-07 |
2.31E-06 |
8.19E-07 |
IL6/MAPK3/MAPK1/KIT/CCL5/SYK/FLT1/LGALS3 |
8 |
| BP |
GO:1904707 |
positive regulation of vascular associated smooth muscle cell proliferation |
5/49 |
50/18903 |
1.84E-07 |
2.44E-06 |
8.65E-07 |
TNF/SRC/MMP9/IGF1/JAK2 |
5 |
| BP |
GO:0097529 |
myeloid leukocyte migration |
8/49 |
242/18903 |
1.84E-07 |
2.44E-06 |
8.65E-07 |
IL6/MAPK3/MAPK1/KIT/CCL5/SYK/FLT1/LGALS3 |
8 |
| BP |
GO:0062012 |
regulation of small molecule metabolic process |
9/49 |
339/18903 |
1.89E-07 |
2.48E-06 |
8.81E-07 |
TNF/AKT1/SRC/PTGS2/IGF1/KIT/SIRT1/NOS3/NR3C1 |
9 |
| BP |
GO:0002768 |
immune response-regulating cell surface receptor signaling pathway |
9/49 |
341/18903 |
1.98E-07 |
2.60E-06 |
9.21E-07 |
SRC/MAPK1/PIK3CA/KIT/HRAS/MAPK8/SYK/LCK/LGALS3 |
9 |
| BP |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
5/49 |
51/18903 |
2.04E-07 |
2.66E-06 |
9.44E-07 |
ESR1/STAT1/RHOA/SIRT1/CASP8 |
5 |
| BP |
GO:0036473 |
cell death in response to oxidative stress |
6/49 |
100/18903 |
2.19E-07 |
2.85E-06 |
1.01E-06 |
TNF/AKT1/JAK2/HGF/SIRT1/MMP3 |
6 |
| BP |
GO:0019216 |
regulation of lipid metabolic process |
9/49 |
347/18903 |
2.30E-07 |
2.97E-06 |
1.05E-06 |
TNF/AKT1/SRC/PTGS2/KIT/SIRT1/IGF1R/NR3C1/FLT1 |
9 |
| BP |
GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway |
6/49 |
101/18903 |
2.33E-07 |
2.99E-06 |
1.06E-06 |
AKT1/SRC/MMP9/PTGS2/MDM2/SIRT1 |
6 |
| BP |
GO:0002262 |
myeloid cell homeostasis |
7/49 |
169/18903 |
2.52E-07 |
3.24E-06 |
1.15E-06 |
IL6/CASP3/STAT1/KIT/JAK2/MAPK14/HMOX1 |
7 |
| BP |
GO:0045861 |
negative regulation of proteolysis |
9/49 |
352/18903 |
2.59E-07 |
3.31E-06 |
1.17E-06 |
TNF/GAPDH/AKT1/SRC/MMP9/PTGS2/HGF/CTSB/PLAU |
9 |
| BP |
GO:1903076 |
regulation of protein localization to plasma membrane |
6/49 |
103/18903 |
2.61E-07 |
3.32E-06 |
1.18E-06 |
TNF/AKT1/EGFR/ITGB1/AR/LGALS3 |
6 |
| BP |
GO:0030728 |
ovulation |
4/49 |
22/18903 |
2.82E-07 |
3.56E-06 |
1.27E-06 |
PTGS2/SIRT1/PGR/NOS3 |
4 |
| BP |
GO:2001242 |
regulation of intrinsic apoptotic signaling pathway |
7/49 |
172/18903 |
2.84E-07 |
3.59E-06 |
1.27E-06 |
AKT1/SRC/MMP9/PTGS2/MDM2/SIRT1/LCK |
7 |
| BP |
GO:0038093 |
Fc receptor signaling pathway |
5/49 |
55/18903 |
2.99E-07 |
3.74E-06 |
1.33E-06 |
SRC/KIT/MAPK8/SYK/LCK |
5 |
| BP |
GO:1904645 |
response to amyloid-beta |
5/49 |
55/18903 |
2.99E-07 |
3.74E-06 |
1.33E-06 |
TNF/MMP9/IGF1/IGF1R/MMP3 |
5 |
| BP |
GO:0032963 |
collagen metabolic process |
6/49 |
107/18903 |
3.28E-07 |
4.08E-06 |
1.45E-06 |
IL6/MMP9/ITGB1/CTSB/MMP3/MMP1 |
6 |
| BP |
GO:0060444 |
branching involved in mammary gland duct morphogenesis |
4/49 |
23/18903 |
3.40E-07 |
4.22E-06 |
1.50E-06 |
SRC/ESR1/PGR/AR |
4 |
| BP |
GO:0014812 |
muscle cell migration |
6/49 |
108/18903 |
3.46E-07 |
4.24E-06 |
1.51E-06 |
SRC/IGF1/RHOA/CCL5/ACE/PLAU |
6 |
| BP |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
6/49 |
108/18903 |
3.46E-07 |
4.24E-06 |
1.51E-06 |
TNF/IL6/AKT1/EGFR/PTGS2/PIK3CA |
6 |
| BP |
GO:0090398 |
cellular senescence |
6/49 |
108/18903 |
3.46E-07 |
4.24E-06 |
1.51E-06 |
HRAS/MAPK8/SIRT1/IGF1R/MAPK14/CDK2 |
6 |
| BP |
GO:0010466 |
negative regulation of peptidase activity |
8/49 |
263/18903 |
3.48E-07 |
4.24E-06 |
1.51E-06 |
TNF/GAPDH/AKT1/SRC/MMP9/PTGS2/HGF/CTSB |
8 |
| BP |
GO:0061756 |
leukocyte adhesion to vascular endothelial cell |
5/49 |
57/18903 |
3.59E-07 |
4.36E-06 |
1.55E-06 |
TNF/IL6/RHOA/ITGB1/SELE |
5 |
| BP |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
6/49 |
109/18903 |
3.66E-07 |
4.43E-06 |
1.57E-06 |
TNF/STAT1/JAK2/SYK/CASP1/CASP8 |
6 |
| BP |
GO:0030522 |
intracellular receptor signaling pathway |
8/49 |
266/18903 |
3.79E-07 |
4.57E-06 |
1.62E-06 |
SRC/ESR1/RHOA/JAK2/SIRT1/PGR/NR3C1/AR |
8 |
| BP |
GO:0032611 |
interleukin-1 beta production |
6/49 |
111/18903 |
4.07E-07 |
4.87E-06 |
1.73E-06 |
TNF/IL6/IGF1/JAK2/CASP1/CASP8 |
6 |
| BP |
GO:0032651 |
regulation of interleukin-1 beta production |
6/49 |
111/18903 |
4.07E-07 |
4.87E-06 |
1.73E-06 |
TNF/IL6/IGF1/JAK2/CASP1/CASP8 |
6 |
| BP |
GO:0051098 |
regulation of binding |
9/49 |
372/18903 |
4.12E-07 |
4.91E-06 |
1.74E-06 |
AKT1/SRC/MMP9/MAPK3/IGF1/JAK2/MAPK8/HMOX1/ACE |
9 |
| BP |
GO:0042129 |
regulation of T cell proliferation |
7/49 |
182/18903 |
4.17E-07 |
4.95E-06 |
1.76E-06 |
IL6/CASP3/IGF1/JAK2/CCL5/SYK/LGALS3 |
7 |
| BP |
GO:0046324 |
regulation of glucose import |
5/49 |
59/18903 |
4.28E-07 |
5.03E-06 |
1.79E-06 |
TNF/AKT1/IGF1/MAPK14/ACE |
5 |
| BP |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
5/49 |
59/18903 |
4.28E-07 |
5.03E-06 |
1.79E-06 |
TNF/AKT1/EGFR/ITGB1/LGALS3 |
5 |
| BP |
GO:0001936 |
regulation of endothelial cell proliferation |
7/49 |
183/18903 |
4.33E-07 |
5.08E-06 |
1.80E-06 |
TNF/AKT1/KDR/STAT1/SIRT1/HMOX1/FLT1 |
7 |
| BP |
GO:0002040 |
sprouting angiogenesis |
7/49 |
185/18903 |
4.66E-07 |
5.44E-06 |
1.93E-06 |
AKT1/PTGS2/KDR/RHOA/ITGB1/HMOX1/JAK1 |
7 |
| BP |
GO:0009408 |
response to heat |
6/49 |
114/18903 |
4.77E-07 |
5.55E-06 |
1.97E-06 |
AKT1/PTGS2/IGF1/SIRT1/HMOX1/NOS3 |
6 |
| BP |
GO:0009266 |
response to temperature stimulus |
7/49 |
186/18903 |
4.83E-07 |
5.57E-06 |
1.98E-06 |
AKT1/PTGS2/IGF1/SIRT1/HMOX1/CASP8/NOS3 |
7 |
| BP |
GO:0043405 |
regulation of MAP kinase activity |
7/49 |
186/18903 |
4.83E-07 |
5.57E-06 |
1.98E-06 |
TNF/EGFR/SRC/KIT/HRAS/SYK/FLT1 |
7 |
| BP |
GO:1904996 |
positive regulation of leukocyte adhesion to vascular endothelial cell |
4/49 |
25/18903 |
4.84E-07 |
5.57E-06 |
1.98E-06 |
TNF/IL6/RHOA/SELE |
4 |
| BP |
GO:0030324 |
lung development |
7/49 |
187/18903 |
5.01E-07 |
5.74E-06 |
2.04E-06 |
TNF/MAPK3/KDR/MAPK1/ACE/PGR/NOS3 |
7 |
| BP |
GO:0061138 |
morphogenesis of a branching epithelium |
7/49 |
188/18903 |
5.19E-07 |
5.93E-06 |
2.10E-06 |
TNF/SRC/ESR1/KDR/HGF/PGR/AR |
7 |
| BP |
GO:0071887 |
leukocyte apoptotic process |
6/49 |
117/18903 |
5.56E-07 |
6.32E-06 |
2.24E-06 |
IL6/AKT1/CASP3/CCL5/SIRT1/LGALS3 |
6 |
| BP |
GO:0070102 |
interleukin-6-mediated signaling pathway |
4/49 |
26/18903 |
5.71E-07 |
6.45E-06 |
2.29E-06 |
IL6/SRC/JAK2/JAK1 |
4 |
| BP |
GO:1903798 |
regulation of miRNA maturation |
4/49 |
26/18903 |
5.71E-07 |
6.45E-06 |
2.29E-06 |
TNF/IL6/EGFR/ESR1 |
4 |
| BP |
GO:0008217 |
regulation of blood pressure |
7/49 |
191/18903 |
5.78E-07 |
6.47E-06 |
2.30E-06 |
TNF/PTGS2/RHOA/HMOX1/ACE/NOS3/AR |
7 |
| BP |
GO:0030323 |
respiratory tube development |
7/49 |
191/18903 |
5.78E-07 |
6.47E-06 |
2.30E-06 |
TNF/MAPK3/KDR/MAPK1/ACE/PGR/NOS3 |
7 |
| BP |
GO:0002718 |
regulation of cytokine production involved in immune response |
6/49 |
118/18903 |
5.85E-07 |
6.50E-06 |
2.31E-06 |
TNF/IL6/KIT/SIRT1/SYK/HMOX1 |
6 |
| BP |
GO:0043200 |
response to amino acid |
6/49 |
118/18903 |
5.85E-07 |
6.50E-06 |
2.31E-06 |
TNF/EGFR/CASP3/RHOA/PIK3CA/IGF1R |
6 |
| BP |
GO:0032731 |
positive regulation of interleukin-1 beta production |
5/49 |
63/18903 |
5.96E-07 |
6.60E-06 |
2.34E-06 |
TNF/IL6/JAK2/CASP1/CASP8 |
5 |
| BP |
GO:0002367 |
cytokine production involved in immune response |
6/49 |
120/18903 |
6.46E-07 |
7.13E-06 |
2.53E-06 |
TNF/IL6/KIT/SIRT1/SYK/HMOX1 |
6 |
| BP |
GO:0032872 |
regulation of stress-activated MAPK cascade |
7/49 |
195/18903 |
6.65E-07 |
7.31E-06 |
2.59E-06 |
TNF/EGFR/MAPK3/MAPK1/HRAS/HGF/IGF1R |
7 |
| BP |
GO:0032355 |
response to estradiol |
6/49 |
121/18903 |
6.78E-07 |
7.43E-06 |
2.64E-06 |
EGFR/CASP3/PTGS2/ESR1/IGF1R/CASP8 |
6 |
| BP |
GO:0031100 |
animal organ regeneration |
5/49 |
65/18903 |
6.97E-07 |
7.61E-06 |
2.70E-06 |
TNF/IL6/HGF/HMOX1/ACE |
5 |
| BP |
GO:0070302 |
regulation of stress-activated protein kinase signaling cascade |
7/49 |
198/18903 |
7.36E-07 |
8.01E-06 |
2.84E-06 |
TNF/EGFR/MAPK3/MAPK1/HRAS/HGF/IGF1R |
7 |
| BP |
GO:0001935 |
endothelial cell proliferation |
7/49 |
199/18903 |
7.62E-07 |
8.23E-06 |
2.92E-06 |
TNF/AKT1/KDR/STAT1/SIRT1/HMOX1/FLT1 |
7 |
| BP |
GO:0009746 |
response to hexose |
7/49 |
199/18903 |
7.62E-07 |
8.23E-06 |
2.92E-06 |
TNF/CASP3/PTGS2/RHOA/PIK3CA/IGF1R/ACE |
7 |
| BP |
GO:0070920 |
regulation of production of small RNA involved in gene silencing by RNA |
4/49 |
28/18903 |
7.79E-07 |
8.39E-06 |
2.98E-06 |
TNF/IL6/EGFR/ESR1 |
4 |
| BP |
GO:0051222 |
positive regulation of protein transport |
8/49 |
294/18903 |
8.07E-07 |
8.66E-06 |
3.07E-06 |
TNF/SRC/PTGS2/IGF1/HRAS/JAK2/MAPK8/MAPK14 |
8 |
| BP |
GO:1904377 |
positive regulation of protein localization to cell periphery |
5/49 |
67/18903 |
8.12E-07 |
8.68E-06 |
3.08E-06 |
TNF/AKT1/EGFR/ITGB1/LGALS3 |
5 |
| BP |
GO:0038127 |
ERBB signaling pathway |
6/49 |
126/18903 |
8.61E-07 |
9.16E-06 |
3.25E-06 |
AKT1/EGFR/SRC/MMP9/MAPK1/PIK3CA |
6 |
| BP |
GO:0001763 |
morphogenesis of a branching structure |
7/49 |
203/18903 |
8.71E-07 |
9.24E-06 |
3.28E-06 |
TNF/SRC/ESR1/KDR/HGF/PGR/AR |
7 |
| BP |
GO:0009615 |
response to virus |
9/49 |
409/18903 |
9.09E-07 |
9.61E-06 |
3.41E-06 |
TNF/IL6/SRC/STAT1/JAK2/CCL5/MAPK14/CASP1/JAK1 |
9 |
| BP |
GO:0034284 |
response to monosaccharide |
7/49 |
207/18903 |
9.92E-07 |
1.05E-05 |
3.71E-06 |
TNF/CASP3/PTGS2/RHOA/PIK3CA/IGF1R/ACE |
7 |
| BP |
GO:0032612 |
interleukin-1 production |
6/49 |
130/18903 |
1.03E-06 |
1.08E-05 |
3.84E-06 |
TNF/IL6/IGF1/JAK2/CASP1/CASP8 |
6 |
| BP |
GO:0032652 |
regulation of interleukin-1 production |
6/49 |
130/18903 |
1.03E-06 |
1.08E-05 |
3.84E-06 |
TNF/IL6/IGF1/JAK2/CASP1/CASP8 |
6 |
| BP |
GO:0010595 |
positive regulation of endothelial cell migration |
6/49 |
131/18903 |
1.08E-06 |
1.13E-05 |
4.00E-06 |
AKT1/PTGS2/KDR/SIRT1/HMOX1/NOS3 |
6 |
| BP |
GO:0071375 |
cellular response to peptide hormone stimulus |
8/49 |
306/18903 |
1.09E-06 |
1.13E-05 |
4.02E-06 |
AKT1/SRC/STAT1/PIK3CA/JAK2/SIRT1/IGF1R/JAK1 |
8 |
| BP |
GO:0060541 |
respiratory system development |
7/49 |
211/18903 |
1.13E-06 |
1.17E-05 |
4.15E-06 |
TNF/MAPK3/KDR/MAPK1/ACE/PGR/NOS3 |
7 |
| BP |
GO:0042098 |
T cell proliferation |
7/49 |
212/18903 |
1.16E-06 |
1.20E-05 |
4.26E-06 |
IL6/CASP3/IGF1/JAK2/CCL5/SYK/LGALS3 |
7 |
| BP |
GO:0001101 |
response to acid chemical |
6/49 |
133/18903 |
1.18E-06 |
1.22E-05 |
4.31E-06 |
TNF/EGFR/CASP3/RHOA/PIK3CA/IGF1R |
6 |
| BP |
GO:0002064 |
epithelial cell development |
7/49 |
213/18903 |
1.20E-06 |
1.23E-05 |
4.36E-06 |
TNF/AKT1/SRC/ESR1/KDR/PGR/AR |
7 |
| BP |
GO:1904951 |
positive regulation of establishment of protein localization |
8/49 |
310/18903 |
1.20E-06 |
1.23E-05 |
4.36E-06 |
TNF/SRC/PTGS2/IGF1/HRAS/JAK2/MAPK8/MAPK14 |
8 |
| BP |
GO:0032943 |
mononuclear cell proliferation |
8/49 |
312/18903 |
1.26E-06 |
1.28E-05 |
4.56E-06 |
IL6/CASP3/IGF1/JAK2/CCL5/SYK/ACE/LGALS3 |
8 |
| BP |
GO:0060485 |
mesenchyme development |
8/49 |
313/18903 |
1.29E-06 |
1.31E-05 |
4.65E-06 |
IL6/MAPK3/IGF1/STAT1/MAPK1/MDM2/HGF/NOS3 |
8 |
| BP |
GO:0050890 |
cognition |
8/49 |
314/18903 |
1.32E-06 |
1.34E-05 |
4.75E-06 |
TNF/EGFR/SRC/CASP3/PTGS2/MAPK1/KIT/ITGB1 |
8 |
| BP |
GO:0032732 |
positive regulation of interleukin-1 production |
5/49 |
74/18903 |
1.34E-06 |
1.34E-05 |
4.75E-06 |
TNF/IL6/JAK2/CASP1/CASP8 |
5 |
| BP |
GO:0035924 |
cellular response to vascular endothelial growth factor stimulus |
5/49 |
74/18903 |
1.34E-06 |
1.34E-05 |
4.75E-06 |
AKT1/KDR/PIK3CA/MAPK14/FLT1 |
5 |
| BP |
GO:2000573 |
positive regulation of DNA biosynthetic process |
5/49 |
74/18903 |
1.34E-06 |
1.34E-05 |
4.75E-06 |
TNF/SRC/MAPK3/MAPK1/HGF |
5 |
| BP |
GO:0031331 |
positive regulation of cellular catabolic process |
9/49 |
429/18903 |
1.35E-06 |
1.35E-05 |
4.78E-06 |
TNF/IL6/AKT1/MAPK3/IGF1/KDR/MDM2/SIRT1/HMOX1 |
9 |
| BP |
GO:0002573 |
myeloid leukocyte differentiation |
7/49 |
218/18903 |
1.40E-06 |
1.39E-05 |
4.94E-06 |
TNF/SRC/MMP9/KIT/SIRT1/MAPK14/CASP8 |
7 |
| BP |
GO:0034101 |
erythrocyte homeostasis |
6/49 |
137/18903 |
1.41E-06 |
1.39E-05 |
4.94E-06 |
CASP3/STAT1/KIT/JAK2/MAPK14/HMOX1 |
6 |
| BP |
GO:0046323 |
glucose import |
5/49 |
75/18903 |
1.43E-06 |
1.41E-05 |
5.00E-06 |
TNF/AKT1/IGF1/MAPK14/ACE |
5 |
| BP |
GO:0009410 |
response to xenobiotic stimulus |
9/49 |
432/18903 |
1.43E-06 |
1.41E-05 |
5.00E-06 |
TNF/SRC/CASP3/PTGS2/STAT1/RHOA/HMOX1/LCK/ACE |
9 |
| BP |
GO:0006809 |
nitric oxide biosynthetic process |
5/49 |
76/18903 |
1.53E-06 |
1.50E-05 |
5.32E-06 |
TNF/AKT1/PTGS2/JAK2/NOS3 |
5 |
| BP |
GO:0010827 |
regulation of glucose transmembrane transport |
5/49 |
77/18903 |
1.63E-06 |
1.59E-05 |
5.66E-06 |
TNF/AKT1/IGF1/MAPK14/ACE |
5 |
| BP |
GO:0050804 |
modulation of chemical synaptic transmission |
9/49 |
448/18903 |
1.93E-06 |
1.88E-05 |
6.68E-06 |
TNF/SRC/PTGS2/MAPK1/KIT/HRAS/JAK2/ITGB1/ACE |
9 |
| BP |
GO:0001542 |
ovulation from ovarian follicle |
3/49 |
10/18903 |
1.94E-06 |
1.88E-05 |
6.69E-06 |
SIRT1/PGR/NOS3 |
3 |
| BP |
GO:0099177 |
regulation of trans-synaptic signaling |
9/49 |
449/18903 |
1.96E-06 |
1.90E-05 |
6.74E-06 |
TNF/SRC/PTGS2/MAPK1/KIT/HRAS/JAK2/ITGB1/ACE |
9 |
| BP |
GO:0043276 |
anoikis |
4/49 |
35/18903 |
1.97E-06 |
1.90E-05 |
6.74E-06 |
AKT1/SRC/PIK3CA/ITGB1 |
4 |
| BP |
GO:1903201 |
regulation of oxidative stress-induced cell death |
5/49 |
80/18903 |
1.97E-06 |
1.90E-05 |
6.74E-06 |
TNF/AKT1/HGF/SIRT1/MMP3 |
5 |
| BP |
GO:0045598 |
regulation of fat cell differentiation |
6/49 |
147/18903 |
2.12E-06 |
2.03E-05 |
7.22E-06 |
TNF/IL6/AKT1/PTGS2/SIRT1/MAPK14 |
6 |
| BP |
GO:0032386 |
regulation of intracellular transport |
8/49 |
336/18903 |
2.19E-06 |
2.10E-05 |
7.44E-06 |
SRC/MAPK3/PTGS2/MAPK1/HRAS/JAK2/MAPK8/MAPK14 |
8 |
| BP |
GO:0032147 |
activation of protein kinase activity |
6/49 |
148/18903 |
2.20E-06 |
2.10E-05 |
7.46E-06 |
EGFR/SRC/IGF1/PIK3CA/JAK2/CCL5 |
6 |
| BP |
GO:0046209 |
nitric oxide metabolic process |
5/49 |
82/18903 |
2.23E-06 |
2.11E-05 |
7.50E-06 |
TNF/AKT1/PTGS2/JAK2/NOS3 |
5 |
| BP |
GO:0051149 |
positive regulation of muscle cell differentiation |
5/49 |
82/18903 |
2.23E-06 |
2.11E-05 |
7.50E-06 |
IGF1/KIT/MDM2/SIRT1/MAPK14 |
5 |
| BP |
GO:0009743 |
response to carbohydrate |
7/49 |
234/18903 |
2.25E-06 |
2.12E-05 |
7.53E-06 |
TNF/CASP3/PTGS2/RHOA/PIK3CA/IGF1R/ACE |
7 |
| BP |
GO:0072593 |
reactive oxygen species metabolic process |
7/49 |
235/18903 |
2.31E-06 |
2.18E-05 |
7.73E-06 |
TNF/RHOA/MPO/MAPK14/SYK/NOS3/MMP3 |
7 |
| BP |
GO:2001057 |
reactive nitrogen species metabolic process |
5/49 |
83/18903 |
2.37E-06 |
2.22E-05 |
7.89E-06 |
TNF/AKT1/PTGS2/JAK2/NOS3 |
5 |
| BP |
GO:0010821 |
regulation of mitochondrion organization |
6/49 |
150/18903 |
2.38E-06 |
2.23E-05 |
7.92E-06 |
AKT1/MMP9/IGF1/KDR/HGF/MAPK8 |
6 |
| BP |
GO:0002274 |
myeloid leukocyte activation |
7/49 |
237/18903 |
2.45E-06 |
2.28E-05 |
8.10E-06 |
TNF/IL6/KIT/JAK2/CCL5/SYK/HMOX1 |
7 |
| BP |
GO:0050670 |
regulation of lymphocyte proliferation |
7/49 |
239/18903 |
2.59E-06 |
2.40E-05 |
8.53E-06 |
IL6/CASP3/IGF1/JAK2/CCL5/SYK/LGALS3 |
7 |
| BP |
GO:0071394 |
cellular response to testosterone stimulus |
3/49 |
11/18903 |
2.66E-06 |
2.44E-05 |
8.68E-06 |
SIRT1/IGF1R/AR |
3 |
| BP |
GO:0071492 |
cellular response to UV-A |
3/49 |
11/18903 |
2.66E-06 |
2.44E-05 |
8.68E-06 |
MMP9/MMP3/MMP1 |
3 |
| BP |
GO:0071803 |
positive regulation of podosome assembly |
3/49 |
11/18903 |
2.66E-06 |
2.44E-05 |
8.68E-06 |
TNF/SRC/RHOA |
3 |
| BP |
GO:0072584 |
caveolin-mediated endocytosis |
3/49 |
11/18903 |
2.66E-06 |
2.44E-05 |
8.68E-06 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0048009 |
insulin-like growth factor receptor signaling pathway |
4/49 |
38/18903 |
2.76E-06 |
2.52E-05 |
8.96E-06 |
AKT1/IGF1/IGF1R/AR |
4 |
| BP |
GO:0043524 |
negative regulation of neuron apoptotic process |
6/49 |
154/18903 |
2.78E-06 |
2.53E-05 |
8.97E-06 |
KDR/RHOA/PIK3CA/HRAS/JAK2/HMOX1 |
6 |
| BP |
GO:0050729 |
positive regulation of inflammatory response |
6/49 |
154/18903 |
2.78E-06 |
2.53E-05 |
8.97E-06 |
TNF/IL6/PTGS2/JAK2/CASP1/ACE |
6 |
| BP |
GO:0032944 |
regulation of mononuclear cell proliferation |
7/49 |
243/18903 |
2.89E-06 |
2.62E-05 |
9.30E-06 |
IL6/CASP3/IGF1/JAK2/CCL5/SYK/LGALS3 |
7 |
| BP |
GO:0010660 |
regulation of muscle cell apoptotic process |
5/49 |
87/18903 |
2.99E-06 |
2.70E-05 |
9.57E-06 |
IGF1/JAK2/SIRT1/IGF1R/HMOX1 |
5 |
| BP |
GO:1900182 |
positive regulation of protein localization to nucleus |
5/49 |
87/18903 |
2.99E-06 |
2.70E-05 |
9.57E-06 |
AKT1/SRC/PTGS2/JAK2/MAPK14 |
5 |
| BP |
GO:0048754 |
branching morphogenesis of an epithelial tube |
6/49 |
157/18903 |
3.11E-06 |
2.79E-05 |
9.91E-06 |
TNF/SRC/ESR1/KDR/PGR/AR |
6 |
| BP |
GO:0048863 |
stem cell differentiation |
7/49 |
248/18903 |
3.30E-06 |
2.96E-05 |
1.05E-05 |
MAPK3/ESR1/MAPK1/KIT/ITGB1/MAPK14/ACE |
7 |
| BP |
GO:0007292 |
female gamete generation |
6/49 |
159/18903 |
3.34E-06 |
2.97E-05 |
1.06E-05 |
SRC/PTGS2/IGF1/SIRT1/PGR/NOS3 |
6 |
| BP |
GO:0036294 |
cellular response to decreased oxygen levels |
6/49 |
159/18903 |
3.34E-06 |
2.97E-05 |
1.06E-05 |
AKT1/SRC/PTGS2/MDM2/SIRT1/HMOX1 |
6 |
| BP |
GO:0034644 |
cellular response to UV |
5/49 |
89/18903 |
3.34E-06 |
2.97E-05 |
1.06E-05 |
MMP9/PTGS2/SIRT1/MMP3/MMP1 |
5 |
| BP |
GO:0048246 |
macrophage chemotaxis |
4/49 |
40/18903 |
3.40E-06 |
3.00E-05 |
1.07E-05 |
MAPK3/MAPK1/CCL5/LGALS3 |
4 |
| BP |
GO:1904994 |
regulation of leukocyte adhesion to vascular endothelial cell |
4/49 |
40/18903 |
3.40E-06 |
3.00E-05 |
1.07E-05 |
TNF/IL6/RHOA/SELE |
4 |
| BP |
GO:0010951 |
negative regulation of endopeptidase activity |
7/49 |
252/18903 |
3.67E-06 |
3.23E-05 |
1.15E-05 |
TNF/GAPDH/AKT1/SRC/MMP9/PTGS2/HGF |
7 |
| BP |
GO:1901216 |
positive regulation of neuron death |
5/49 |
91/18903 |
3.73E-06 |
3.28E-05 |
1.16E-05 |
TNF/CASP3/RHOA/CASP8/NR3C1 |
5 |
| BP |
GO:0045787 |
positive regulation of cell cycle |
8/49 |
362/18903 |
3.81E-06 |
3.33E-05 |
1.18E-05 |
TNF/AKT1/EGFR/SRC/IGF1/RHOA/MDM2/IGF1R |
8 |
| BP |
GO:0010657 |
muscle cell apoptotic process |
5/49 |
92/18903 |
3.94E-06 |
3.44E-05 |
1.22E-05 |
IGF1/JAK2/SIRT1/IGF1R/HMOX1 |
5 |
| BP |
GO:0051100 |
negative regulation of binding |
6/49 |
164/18903 |
4.00E-06 |
3.48E-05 |
1.24E-05 |
AKT1/MAPK3/JAK2/MAPK8/HMOX1/ACE |
6 |
| BP |
GO:0010907 |
positive regulation of glucose metabolic process |
4/49 |
42/18903 |
4.15E-06 |
3.58E-05 |
1.27E-05 |
AKT1/SRC/IGF1/SIRT1 |
4 |
| BP |
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
4/49 |
42/18903 |
4.15E-06 |
3.58E-05 |
1.27E-05 |
TNF/AKT1/PTGS2/JAK2 |
4 |
| BP |
GO:0071354 |
cellular response to interleukin-6 |
4/49 |
42/18903 |
4.15E-06 |
3.58E-05 |
1.27E-05 |
IL6/SRC/JAK2/JAK1 |
4 |
| BP |
GO:0090068 |
positive regulation of cell cycle process |
7/49 |
260/18903 |
4.51E-06 |
3.88E-05 |
1.38E-05 |
TNF/AKT1/EGFR/IGF1/RHOA/MDM2/IGF1R |
7 |
| BP |
GO:0034109 |
homotypic cell-cell adhesion |
5/49 |
95/18903 |
4.62E-06 |
3.95E-05 |
1.40E-05 |
IL6/JAK2/CCL5/SYK/JAK1 |
5 |
| BP |
GO:1900407 |
regulation of cellular response to oxidative stress |
5/49 |
95/18903 |
4.62E-06 |
3.95E-05 |
1.40E-05 |
TNF/AKT1/HGF/SIRT1/MMP3 |
5 |
| BP |
GO:0003015 |
heart process |
7/49 |
261/18903 |
4.62E-06 |
3.95E-05 |
1.40E-05 |
TNF/SRC/PIK3CA/JAK2/MDM2/ACE/NOS3 |
7 |
| BP |
GO:0003073 |
regulation of systemic arterial blood pressure |
5/49 |
96/18903 |
4.86E-06 |
4.12E-05 |
1.46E-05 |
TNF/RHOA/ACE/NOS3/AR |
5 |
| BP |
GO:1903522 |
regulation of blood circulation |
7/49 |
263/18903 |
4.86E-06 |
4.12E-05 |
1.46E-05 |
TNF/PTGS2/RHOA/JAK2/MDM2/ACE/NOS3 |
7 |
| BP |
GO:1904407 |
positive regulation of nitric oxide metabolic process |
4/49 |
44/18903 |
5.01E-06 |
4.24E-05 |
1.51E-05 |
TNF/AKT1/PTGS2/JAK2 |
4 |
| BP |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
7/49 |
266/18903 |
5.24E-06 |
4.42E-05 |
1.57E-05 |
TNF/IL6/AKT1/ESR1/KIT/JAK2/AR |
7 |
| BP |
GO:1903034 |
regulation of response to wounding |
6/49 |
172/18903 |
5.26E-06 |
4.43E-05 |
1.57E-05 |
TNF/HRAS/ITGB1/IGF1R/NOS3/PLAU |
6 |
| BP |
GO:0031295 |
T cell costimulation |
4/49 |
45/18903 |
5.49E-06 |
4.58E-05 |
1.63E-05 |
AKT1/SRC/PIK3CA/LCK |
4 |
| BP |
GO:0060964 |
regulation of miRNA-mediated gene silencing |
4/49 |
45/18903 |
5.49E-06 |
4.58E-05 |
1.63E-05 |
TNF/IL6/EGFR/ESR1 |
4 |
| BP |
GO:0070741 |
response to interleukin-6 |
4/49 |
45/18903 |
5.49E-06 |
4.58E-05 |
1.63E-05 |
IL6/SRC/JAK2/JAK1 |
4 |
| BP |
GO:0032868 |
response to insulin |
7/49 |
269/18903 |
5.64E-06 |
4.69E-05 |
1.66E-05 |
AKT1/SRC/STAT1/PIK3CA/SIRT1/IGF1R/MAPK14 |
7 |
| BP |
GO:0071453 |
cellular response to oxygen levels |
6/49 |
175/18903 |
5.81E-06 |
4.82E-05 |
1.71E-05 |
AKT1/SRC/PTGS2/MDM2/SIRT1/HMOX1 |
6 |
| BP |
GO:0071801 |
regulation of podosome assembly |
3/49 |
14/18903 |
5.84E-06 |
4.83E-05 |
1.72E-05 |
TNF/SRC/RHOA |
3 |
| BP |
GO:0007611 |
learning or memory |
7/49 |
273/18903 |
6.21E-06 |
5.12E-05 |
1.82E-05 |
EGFR/SRC/CASP3/PTGS2/MAPK1/KIT/ITGB1 |
7 |
| BP |
GO:0001894 |
tissue homeostasis |
7/49 |
275/18903 |
6.51E-06 |
5.30E-05 |
1.88E-05 |
IL6/SRC/PTGS2/KDR/ITGB1/SYK/NOS3 |
7 |
| BP |
GO:0019218 |
regulation of steroid metabolic process |
5/49 |
102/18903 |
6.55E-06 |
5.30E-05 |
1.88E-05 |
TNF/KIT/SIRT1/IGF1R/NR3C1 |
5 |
| BP |
GO:0002861 |
regulation of inflammatory response to antigenic stimulus |
4/49 |
47/18903 |
6.55E-06 |
5.30E-05 |
1.88E-05 |
TNF/SRC/MAPK14/SYK |
4 |
| BP |
GO:0031294 |
lymphocyte costimulation |
4/49 |
47/18903 |
6.55E-06 |
5.30E-05 |
1.88E-05 |
AKT1/SRC/PIK3CA/LCK |
4 |
| BP |
GO:0070849 |
response to epidermal growth factor |
4/49 |
47/18903 |
6.55E-06 |
5.30E-05 |
1.88E-05 |
AKT1/EGFR/MAPK3/MAPK1 |
4 |
| BP |
GO:0090199 |
regulation of release of cytochrome c from mitochondria |
4/49 |
47/18903 |
6.55E-06 |
5.30E-05 |
1.88E-05 |
AKT1/MMP9/IGF1/HGF |
4 |
| BP |
GO:1900368 |
regulation of post-transcriptional gene silencing by RNA |
4/49 |
47/18903 |
6.55E-06 |
5.30E-05 |
1.88E-05 |
TNF/IL6/EGFR/ESR1 |
4 |
| BP |
GO:0048771 |
tissue remodeling |
6/49 |
179/18903 |
6.61E-06 |
5.34E-05 |
1.90E-05 |
IL6/SRC/MDM2/SYK/ACE/NOS3 |
6 |
| BP |
GO:0001701 |
in utero embryonic development |
8/49 |
393/18903 |
6.96E-06 |
5.60E-05 |
1.99E-05 |
AKT1/EGFR/IGF1/MAPK1/ITGB1/CASP8/NOS3/AR |
8 |
| BP |
GO:0060147 |
regulation of post-transcriptional gene silencing |
4/49 |
48/18903 |
7.13E-06 |
5.73E-05 |
2.03E-05 |
TNF/IL6/EGFR/ESR1 |
4 |
| BP |
GO:0046425 |
regulation of receptor signaling pathway via JAK-STAT |
5/49 |
104/18903 |
7.20E-06 |
5.75E-05 |
2.04E-05 |
TNF/IL6/KIT/JAK2/CCL5 |
5 |
| BP |
GO:1902882 |
regulation of response to oxidative stress |
5/49 |
104/18903 |
7.20E-06 |
5.75E-05 |
2.04E-05 |
TNF/AKT1/HGF/SIRT1/MMP3 |
5 |
| BP |
GO:0046890 |
regulation of lipid biosynthetic process |
6/49 |
182/18903 |
7.27E-06 |
5.80E-05 |
2.06E-05 |
TNF/AKT1/PTGS2/SIRT1/IGF1R/NR3C1 |
6 |
| BP |
GO:0031281 |
positive regulation of cyclase activity |
4/49 |
49/18903 |
7.75E-06 |
6.16E-05 |
2.19E-05 |
MAPK3/MAPK8/MAPK14/NOS3 |
4 |
| BP |
GO:0042102 |
positive regulation of T cell proliferation |
5/49 |
106/18903 |
7.90E-06 |
6.27E-05 |
2.22E-05 |
IL6/IGF1/JAK2/CCL5/SYK |
5 |
| BP |
GO:0002444 |
myeloid leukocyte mediated immunity |
5/49 |
107/18903 |
8.27E-06 |
6.53E-05 |
2.32E-05 |
IL6/KIT/SYK/HMOX1/ACE |
5 |
| BP |
GO:0010906 |
regulation of glucose metabolic process |
5/49 |
107/18903 |
8.27E-06 |
6.53E-05 |
2.32E-05 |
AKT1/SRC/IGF1/SIRT1/NR3C1 |
5 |
| BP |
GO:0060966 |
regulation of gene silencing by RNA |
4/49 |
50/18903 |
8.41E-06 |
6.58E-05 |
2.33E-05 |
TNF/IL6/EGFR/ESR1 |
4 |
| BP |
GO:0061082 |
myeloid leukocyte cytokine production |
4/49 |
50/18903 |
8.41E-06 |
6.58E-05 |
2.33E-05 |
KIT/SIRT1/SYK/HMOX1 |
4 |
| BP |
GO:1902041 |
regulation of extrinsic apoptotic signaling pathway via death domain receptors |
4/49 |
50/18903 |
8.41E-06 |
6.58E-05 |
2.33E-05 |
HGF/HMOX1/NOS3/LGALS3 |
4 |
| BP |
GO:0002700 |
regulation of production of molecular mediator of immune response |
6/49 |
187/18903 |
8.49E-06 |
6.63E-05 |
2.35E-05 |
TNF/IL6/KIT/SIRT1/SYK/HMOX1 |
6 |
| BP |
GO:0008637 |
apoptotic mitochondrial changes |
5/49 |
108/18903 |
8.66E-06 |
6.74E-05 |
2.39E-05 |
AKT1/MMP9/IGF1/HGF/MAPK8 |
5 |
| BP |
GO:1903799 |
negative regulation of miRNA maturation |
3/49 |
16/18903 |
8.95E-06 |
6.95E-05 |
2.47E-05 |
TNF/IL6/ESR1 |
3 |
| BP |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
6/49 |
189/18903 |
9.03E-06 |
6.99E-05 |
2.48E-05 |
TNF/GAPDH/RHOA/CASP1/HMOX1/CASP8 |
6 |
| BP |
GO:0060688 |
regulation of morphogenesis of a branching structure |
4/49 |
51/18903 |
9.10E-06 |
7.03E-05 |
2.50E-05 |
TNF/ESR1/HGF/AR |
4 |
| BP |
GO:0042692 |
muscle cell differentiation |
8/49 |
409/18903 |
9.30E-06 |
7.17E-05 |
2.55E-05 |
AKT1/CASP3/IGF1/KIT/ITGB1/MDM2/SIRT1/MAPK14 |
8 |
| BP |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
5/49 |
110/18903 |
9.47E-06 |
7.26E-05 |
2.58E-05 |
AKT1/EGFR/SRC/MMP9/PIK3CA |
5 |
| BP |
GO:0043254 |
regulation of protein-containing complex assembly |
8/49 |
410/18903 |
9.47E-06 |
7.26E-05 |
2.58E-05 |
TNF/SRC/ESR1/RHOA/SYK/MMP3/MMP1/LGALS3 |
8 |
| BP |
GO:0010543 |
regulation of platelet activation |
4/49 |
52/18903 |
9.84E-06 |
7.53E-05 |
2.67E-05 |
IL6/JAK2/SYK/NOS3 |
4 |
| BP |
GO:0010656 |
negative regulation of muscle cell apoptotic process |
4/49 |
53/18903 |
1.06E-05 |
8.09E-05 |
2.87E-05 |
IGF1/JAK2/IGF1R/HMOX1 |
4 |
| BP |
GO:0048146 |
positive regulation of fibroblast proliferation |
4/49 |
53/18903 |
1.06E-05 |
8.09E-05 |
2.87E-05 |
EGFR/IGF1/ESR1/HRAS |
4 |
| BP |
GO:1904659 |
glucose transmembrane transport |
5/49 |
113/18903 |
1.08E-05 |
8.19E-05 |
2.91E-05 |
TNF/AKT1/IGF1/MAPK14/ACE |
5 |
| BP |
GO:1904892 |
regulation of receptor signaling pathway via STAT |
5/49 |
115/18903 |
1.18E-05 |
8.89E-05 |
3.15E-05 |
TNF/IL6/KIT/JAK2/CCL5 |
5 |
| BP |
GO:0071897 |
DNA biosynthetic process |
6/49 |
198/18903 |
1.18E-05 |
8.89E-05 |
3.15E-05 |
TNF/SRC/MAPK3/MAPK1/HGF/SIRT1 |
6 |
| BP |
GO:0010959 |
regulation of metal ion transport |
8/49 |
423/18903 |
1.19E-05 |
8.95E-05 |
3.18E-05 |
AKT1/PTGS2/RHOA/ITGB1/CCL5/ACE/NOS3/LGALS3 |
8 |
| BP |
GO:0008645 |
hexose transmembrane transport |
5/49 |
116/18903 |
1.23E-05 |
9.19E-05 |
3.26E-05 |
TNF/AKT1/IGF1/MAPK14/ACE |
5 |
| BP |
GO:0098586 |
cellular response to virus |
5/49 |
116/18903 |
1.23E-05 |
9.19E-05 |
3.26E-05 |
IL6/JAK2/CCL5/MAPK14/JAK1 |
5 |
| BP |
GO:0043525 |
positive regulation of neuron apoptotic process |
4/49 |
55/18903 |
1.23E-05 |
9.22E-05 |
3.27E-05 |
TNF/CASP3/RHOA/NR3C1 |
4 |
| BP |
GO:0043393 |
regulation of protein binding |
6/49 |
200/18903 |
1.25E-05 |
9.29E-05 |
3.30E-05 |
AKT1/SRC/MMP9/MAPK3/MAPK8/ACE |
6 |
| BP |
GO:0046651 |
lymphocyte proliferation |
7/49 |
305/18903 |
1.28E-05 |
9.50E-05 |
3.37E-05 |
IL6/CASP3/IGF1/JAK2/CCL5/SYK/LGALS3 |
7 |
| BP |
GO:0051770 |
positive regulation of nitric-oxide synthase biosynthetic process |
3/49 |
18/18903 |
1.30E-05 |
9.60E-05 |
3.41E-05 |
KDR/STAT1/JAK2 |
3 |
| BP |
GO:2000641 |
regulation of early endosome to late endosome transport |
3/49 |
18/18903 |
1.30E-05 |
9.60E-05 |
3.41E-05 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:2000811 |
negative regulation of anoikis |
3/49 |
18/18903 |
1.30E-05 |
9.60E-05 |
3.41E-05 |
SRC/PIK3CA/ITGB1 |
3 |
| BP |
GO:0034504 |
protein localization to nucleus |
7/49 |
306/18903 |
1.30E-05 |
9.61E-05 |
3.41E-05 |
AKT1/SRC/PTGS2/JAK2/MDM2/MAPK14/SYK |
7 |
| BP |
GO:0001836 |
release of cytochrome c from mitochondria |
4/49 |
56/18903 |
1.33E-05 |
9.72E-05 |
3.45E-05 |
AKT1/MMP9/IGF1/HGF |
4 |
| BP |
GO:0010676 |
positive regulation of cellular carbohydrate metabolic process |
4/49 |
56/18903 |
1.33E-05 |
9.72E-05 |
3.45E-05 |
AKT1/SRC/IGF1/SIRT1 |
4 |
| BP |
GO:0044403 |
biological process involved in symbiotic interaction |
7/49 |
307/18903 |
1.33E-05 |
9.74E-05 |
3.46E-05 |
GAPDH/EGFR/SRC/JAK2/ITGB1/CCL5/CTSB |
7 |
| BP |
GO:0015749 |
monosaccharide transmembrane transport |
5/49 |
119/18903 |
1.39E-05 |
0.0001013 |
3.60E-05 |
TNF/AKT1/IGF1/MAPK14/ACE |
5 |
| BP |
GO:0035196 |
miRNA processing |
4/49 |
57/18903 |
1.42E-05 |
0.0001035 |
3.67E-05 |
TNF/IL6/EGFR/ESR1 |
4 |
| BP |
GO:0032102 |
negative regulation of response to external stimulus |
8/49 |
436/18903 |
1.48E-05 |
0.0001069 |
3.79E-05 |
TNF/SRC/IGF1/HGF/MAPK14/SYK/NOS3/PLAU |
8 |
| BP |
GO:0002429 |
immune response-activating cell surface receptor signaling pathway |
7/49 |
312/18903 |
1.48E-05 |
0.0001069 |
3.79E-05 |
SRC/MAPK1/PIK3CA/HRAS/SYK/LCK/LGALS3 |
7 |
| BP |
GO:0002757 |
immune response-activating signal transduction |
7/49 |
312/18903 |
1.48E-05 |
0.0001069 |
3.79E-05 |
SRC/MAPK1/PIK3CA/HRAS/SYK/LCK/LGALS3 |
7 |
| BP |
GO:0051101 |
regulation of DNA binding |
5/49 |
121/18903 |
1.51E-05 |
0.0001083 |
3.84E-05 |
MMP9/IGF1/JAK2/MAPK8/HMOX1 |
5 |
| BP |
GO:2000278 |
regulation of DNA biosynthetic process |
5/49 |
121/18903 |
1.51E-05 |
0.0001083 |
3.84E-05 |
TNF/SRC/MAPK3/MAPK1/HGF |
5 |
| BP |
GO:0001541 |
ovarian follicle development |
4/49 |
58/18903 |
1.53E-05 |
0.0001091 |
3.87E-05 |
SRC/ESR1/KDR/KIT |
4 |
| BP |
GO:0048010 |
vascular endothelial growth factor receptor signaling pathway |
4/49 |
58/18903 |
1.53E-05 |
0.0001091 |
3.87E-05 |
SRC/KDR/MAPK14/FLT1 |
4 |
| BP |
GO:0010759 |
positive regulation of macrophage chemotaxis |
3/49 |
19/18903 |
1.54E-05 |
0.0001095 |
3.89E-05 |
MAPK3/MAPK1/CCL5 |
3 |
| BP |
GO:0071800 |
podosome assembly |
3/49 |
19/18903 |
1.54E-05 |
0.0001095 |
3.89E-05 |
TNF/SRC/RHOA |
3 |
| BP |
GO:0019932 |
second-messenger-mediated signaling |
7/49 |
314/18903 |
1.54E-05 |
0.0001095 |
3.89E-05 |
TNF/EGFR/IGF1/KDR/SYK/NOS3/SELE |
7 |
| BP |
GO:0032869 |
cellular response to insulin stimulus |
6/49 |
208/18903 |
1.56E-05 |
0.0001104 |
3.92E-05 |
AKT1/SRC/STAT1/PIK3CA/SIRT1/IGF1R |
6 |
| BP |
GO:0008286 |
insulin receptor signaling pathway |
5/49 |
122/18903 |
1.57E-05 |
0.0001108 |
3.93E-05 |
AKT1/SRC/PIK3CA/SIRT1/IGF1R |
5 |
| BP |
GO:0071482 |
cellular response to light stimulus |
5/49 |
123/18903 |
1.63E-05 |
0.0001149 |
4.08E-05 |
MMP9/PTGS2/SIRT1/MMP3/MMP1 |
5 |
| BP |
GO:0061098 |
positive regulation of protein tyrosine kinase activity |
4/49 |
59/18903 |
1.63E-05 |
0.0001149 |
4.08E-05 |
EGFR/SRC/CCL5/ACE |
4 |
| BP |
GO:1905517 |
macrophage migration |
4/49 |
60/18903 |
1.75E-05 |
0.0001226 |
4.35E-05 |
MAPK3/MAPK1/CCL5/LGALS3 |
4 |
| BP |
GO:0014856 |
skeletal muscle cell proliferation |
3/49 |
20/18903 |
1.81E-05 |
0.0001268 |
4.50E-05 |
SRC/JAK2/HGF |
3 |
| BP |
GO:0002683 |
negative regulation of immune system process |
8/49 |
449/18903 |
1.83E-05 |
0.0001274 |
4.52E-05 |
TNF/AKT1/SRC/CASP3/MAPK14/SYK/HMOX1/LGALS3 |
8 |
| BP |
GO:0048568 |
embryonic organ development |
8/49 |
449/18903 |
1.83E-05 |
0.0001274 |
4.52E-05 |
TNF/AKT1/EGFR/MAPK3/KDR/MAPK1/KIT/CASP8 |
8 |
| BP |
GO:0046456 |
icosanoid biosynthetic process |
4/49 |
61/18903 |
1.87E-05 |
0.0001295 |
4.60E-05 |
PTGS2/SIRT1/SYK/CASP1 |
4 |
| BP |
GO:0070918 |
small regulatory ncRNA processing |
4/49 |
61/18903 |
1.87E-05 |
0.0001295 |
4.60E-05 |
TNF/IL6/EGFR/ESR1 |
4 |
| BP |
GO:0031647 |
regulation of protein stability |
7/49 |
325/18903 |
1.92E-05 |
0.0001333 |
4.73E-05 |
GAPDH/SRC/CASP3/IGF1/MAPK1/MDM2/SIRT1 |
7 |
| BP |
GO:0030218 |
erythrocyte differentiation |
5/49 |
128/18903 |
1.98E-05 |
0.0001366 |
4.85E-05 |
CASP3/STAT1/KIT/JAK2/MAPK14 |
5 |
| BP |
GO:0022617 |
extracellular matrix disassembly |
4/49 |
62/18903 |
1.99E-05 |
0.0001369 |
4.86E-05 |
IL6/MMP9/MMP3/MMP1 |
4 |
| BP |
GO:0045428 |
regulation of nitric oxide biosynthetic process |
4/49 |
62/18903 |
1.99E-05 |
0.0001369 |
4.86E-05 |
TNF/AKT1/PTGS2/JAK2 |
4 |
| BP |
GO:0003012 |
muscle system process |
8/49 |
455/18903 |
2.01E-05 |
0.0001379 |
4.90E-05 |
TNF/PTGS2/IGF1/RHOA/PIK3CA/KIT/HMOX1/NOS3 |
8 |
| BP |
GO:0090201 |
negative regulation of release of cytochrome c from mitochondria |
3/49 |
21/18903 |
2.11E-05 |
0.0001443 |
5.12E-05 |
AKT1/IGF1/HGF |
3 |
| BP |
GO:0071621 |
granulocyte chemotaxis |
5/49 |
130/18903 |
2.13E-05 |
0.0001456 |
5.17E-05 |
MAPK3/MAPK1/CCL5/SYK/LGALS3 |
5 |
| BP |
GO:0009895 |
negative regulation of catabolic process |
7/49 |
332/18903 |
2.21E-05 |
0.0001504 |
5.34E-05 |
TNF/AKT1/EGFR/PIK3CA/HGF/MAPK14/HMOX1 |
7 |
| BP |
GO:0060249 |
anatomical structure homeostasis |
7/49 |
333/18903 |
2.25E-05 |
0.0001529 |
5.43E-05 |
IL6/SRC/PTGS2/KDR/ITGB1/SYK/NOS3 |
7 |
| BP |
GO:0050918 |
positive chemotaxis |
4/49 |
64/18903 |
2.26E-05 |
0.0001529 |
5.43E-05 |
KDR/CCL5/HGF/LGALS3 |
4 |
| BP |
GO:0071384 |
cellular response to corticosteroid stimulus |
4/49 |
64/18903 |
2.26E-05 |
0.0001529 |
5.43E-05 |
JAK2/IGF1R/ACE/NR3C1 |
4 |
| BP |
GO:0034219 |
carbohydrate transmembrane transport |
5/49 |
132/18903 |
2.29E-05 |
0.0001549 |
5.50E-05 |
TNF/AKT1/IGF1/MAPK14/ACE |
5 |
| BP |
GO:0050435 |
amyloid-beta metabolic process |
4/49 |
65/18903 |
2.40E-05 |
0.0001611 |
5.72E-05 |
TNF/CASP3/IGF1/ACE |
4 |
| BP |
GO:0080164 |
regulation of nitric oxide metabolic process |
4/49 |
65/18903 |
2.40E-05 |
0.0001611 |
5.72E-05 |
TNF/AKT1/PTGS2/JAK2 |
4 |
| BP |
GO:1905330 |
regulation of morphogenesis of an epithelium |
4/49 |
65/18903 |
2.40E-05 |
0.0001611 |
5.72E-05 |
TNF/ESR1/HGF/AR |
4 |
| BP |
GO:1990778 |
protein localization to cell periphery |
7/49 |
337/18903 |
2.43E-05 |
0.0001623 |
5.76E-05 |
TNF/AKT1/EGFR/HRAS/ITGB1/AR/LGALS3 |
7 |
| BP |
GO:0051767 |
nitric-oxide synthase biosynthetic process |
3/49 |
22/18903 |
2.43E-05 |
0.0001623 |
5.76E-05 |
KDR/STAT1/JAK2 |
3 |
| BP |
GO:0051769 |
regulation of nitric-oxide synthase biosynthetic process |
3/49 |
22/18903 |
2.43E-05 |
0.0001623 |
5.76E-05 |
KDR/STAT1/JAK2 |
3 |
| BP |
GO:0043467 |
regulation of generation of precursor metabolites and energy |
5/49 |
134/18903 |
2.47E-05 |
0.000164 |
5.82E-05 |
TNF/AKT1/IGF1/RHOA/PIK3CA |
5 |
| BP |
GO:0010001 |
glial cell differentiation |
6/49 |
227/18903 |
2.55E-05 |
0.0001689 |
5.99E-05 |
TNF/IL6/AKT1/MAPK3/MAPK1/RHOA |
6 |
| BP |
GO:0035270 |
endocrine system development |
5/49 |
135/18903 |
2.56E-05 |
0.0001689 |
5.99E-05 |
IL6/AKT1/MAPK3/MAPK1/NR3C1 |
5 |
| BP |
GO:1900180 |
regulation of protein localization to nucleus |
5/49 |
135/18903 |
2.56E-05 |
0.0001689 |
5.99E-05 |
AKT1/SRC/PTGS2/JAK2/MAPK14 |
5 |
| BP |
GO:0061041 |
regulation of wound healing |
5/49 |
137/18903 |
2.74E-05 |
0.0001808 |
6.42E-05 |
TNF/HRAS/ITGB1/NOS3/PLAU |
5 |
| BP |
GO:0060965 |
negative regulation of miRNA-mediated gene silencing |
3/49 |
23/18903 |
2.79E-05 |
0.0001835 |
6.51E-05 |
TNF/IL6/ESR1 |
3 |
| BP |
GO:0090335 |
regulation of brown fat cell differentiation |
3/49 |
23/18903 |
2.79E-05 |
0.0001835 |
6.51E-05 |
PTGS2/SIRT1/MAPK14 |
3 |
| BP |
GO:0031669 |
cellular response to nutrient levels |
6/49 |
231/18903 |
2.81E-05 |
0.0001843 |
6.54E-05 |
MAPK3/MAPK1/MAPK8/SIRT1/IGF1R/HMOX1 |
6 |
| BP |
GO:0051051 |
negative regulation of transport |
8/49 |
479/18903 |
2.90E-05 |
0.0001897 |
6.73E-05 |
TNF/AKT1/MMP9/PTGS2/HMOX1/ACE/NOS3/LGALS3 |
8 |
| BP |
GO:0050852 |
T cell receptor signaling pathway |
5/49 |
139/18903 |
2.94E-05 |
0.0001918 |
6.81E-05 |
MAPK1/PIK3CA/HRAS/LCK/LGALS3 |
5 |
| BP |
GO:0060348 |
bone development |
6/49 |
233/18903 |
2.95E-05 |
0.0001921 |
6.82E-05 |
SRC/IGF1/KDR/RHOA/KIT/MAPK14 |
6 |
| BP |
GO:0001889 |
liver development |
5/49 |
141/18903 |
3.15E-05 |
0.0002041 |
7.24E-05 |
TNF/IL6/PIK3CA/HGF/HMOX1 |
5 |
| BP |
GO:0070555 |
response to interleukin-1 |
5/49 |
141/18903 |
3.15E-05 |
0.0002041 |
7.24E-05 |
IL6/SRC/MAPK3/CCL5/SELE |
5 |
| BP |
GO:0060149 |
negative regulation of post-transcriptional gene silencing |
3/49 |
24/18903 |
3.19E-05 |
0.0002053 |
7.29E-05 |
TNF/IL6/ESR1 |
3 |
| BP |
GO:0060967 |
negative regulation of gene silencing by RNA |
3/49 |
24/18903 |
3.19E-05 |
0.0002053 |
7.29E-05 |
TNF/IL6/ESR1 |
3 |
| BP |
GO:1900369 |
negative regulation of post-transcriptional gene silencing by RNA |
3/49 |
24/18903 |
3.19E-05 |
0.0002053 |
7.29E-05 |
TNF/IL6/ESR1 |
3 |
| BP |
GO:0032722 |
positive regulation of chemokine production |
4/49 |
70/18903 |
3.22E-05 |
0.000207 |
7.35E-05 |
TNF/IL6/SYK/HMOX1 |
4 |
| BP |
GO:0010212 |
response to ionizing radiation |
5/49 |
143/18903 |
3.37E-05 |
0.000216 |
7.67E-05 |
CASP3/HRAS/MDM2/SIRT1/MAPK14 |
5 |
| BP |
GO:0002548 |
monocyte chemotaxis |
4/49 |
71/18903 |
3.41E-05 |
0.000218 |
7.74E-05 |
IL6/CCL5/FLT1/LGALS3 |
4 |
| BP |
GO:0050921 |
positive regulation of chemotaxis |
5/49 |
144/18903 |
3.48E-05 |
0.0002219 |
7.88E-05 |
IL6/MAPK3/KDR/MAPK1/CCL5 |
5 |
| BP |
GO:0061008 |
hepaticobiliary system development |
5/49 |
144/18903 |
3.48E-05 |
0.0002219 |
7.88E-05 |
TNF/IL6/PIK3CA/HGF/HMOX1 |
5 |
| BP |
GO:0033143 |
regulation of intracellular steroid hormone receptor signaling pathway |
4/49 |
72/18903 |
3.60E-05 |
0.0002289 |
8.12E-05 |
SRC/RHOA/SIRT1/AR |
4 |
| BP |
GO:2000209 |
regulation of anoikis |
3/49 |
25/18903 |
3.62E-05 |
0.0002294 |
8.14E-05 |
SRC/PIK3CA/ITGB1 |
3 |
| BP |
GO:0050671 |
positive regulation of lymphocyte proliferation |
5/49 |
146/18903 |
3.72E-05 |
0.0002356 |
8.36E-05 |
IL6/IGF1/JAK2/CCL5/SYK |
5 |
| BP |
GO:0071677 |
positive regulation of mononuclear cell migration |
4/49 |
73/18903 |
3.80E-05 |
0.0002402 |
8.53E-05 |
TNF/RHOA/CCL5/LGALS3 |
4 |
| BP |
GO:0045444 |
fat cell differentiation |
6/49 |
244/18903 |
3.82E-05 |
0.0002409 |
8.55E-05 |
TNF/IL6/AKT1/PTGS2/SIRT1/MAPK14 |
6 |
| BP |
GO:0035296 |
regulation of tube diameter |
5/49 |
147/18903 |
3.85E-05 |
0.0002414 |
8.57E-05 |
TNF/PTGS2/RHOA/ACE/NOS3 |
5 |
| BP |
GO:0097746 |
blood vessel diameter maintenance |
5/49 |
147/18903 |
3.85E-05 |
0.0002414 |
8.57E-05 |
TNF/PTGS2/RHOA/ACE/NOS3 |
5 |
| BP |
GO:0035150 |
regulation of tube size |
5/49 |
148/18903 |
3.97E-05 |
0.0002488 |
8.83E-05 |
TNF/PTGS2/RHOA/ACE/NOS3 |
5 |
| BP |
GO:0001649 |
osteoblast differentiation |
6/49 |
246/18903 |
4.00E-05 |
0.0002501 |
8.88E-05 |
TNF/IL6/AKT1/IGF1/HGF/MAPK14 |
6 |
| BP |
GO:0060333 |
interferon-gamma-mediated signaling pathway |
3/49 |
26/18903 |
4.08E-05 |
0.000254 |
9.02E-05 |
STAT1/JAK2/JAK1 |
3 |
| BP |
GO:1905523 |
positive regulation of macrophage migration |
3/49 |
26/18903 |
4.08E-05 |
0.000254 |
9.02E-05 |
MAPK3/MAPK1/CCL5 |
3 |
| BP |
GO:0032946 |
positive regulation of mononuclear cell proliferation |
5/49 |
149/18903 |
4.10E-05 |
0.0002543 |
9.03E-05 |
IL6/IGF1/JAK2/CCL5/SYK |
5 |
| BP |
GO:2000377 |
regulation of reactive oxygen species metabolic process |
5/49 |
149/18903 |
4.10E-05 |
0.0002543 |
9.03E-05 |
TNF/RHOA/MAPK14/SYK/MMP3 |
5 |
| BP |
GO:0042593 |
glucose homeostasis |
6/49 |
248/18903 |
4.19E-05 |
0.000259 |
9.19E-05 |
IL6/AKT1/PIK3CA/SIRT1/IGF1R/ACE |
6 |
| BP |
GO:0016239 |
positive regulation of macroautophagy |
4/49 |
75/18903 |
4.23E-05 |
0.0002596 |
9.21E-05 |
MAPK3/KDR/SIRT1/HMOX1 |
4 |
| BP |
GO:0032890 |
regulation of organic acid transport |
4/49 |
75/18903 |
4.23E-05 |
0.0002596 |
9.21E-05 |
TNF/AKT1/ITGB1/SYK |
4 |
| BP |
GO:0050810 |
regulation of steroid biosynthetic process |
4/49 |
75/18903 |
4.23E-05 |
0.0002596 |
9.21E-05 |
TNF/SIRT1/IGF1R/NR3C1 |
4 |
| BP |
GO:0071479 |
cellular response to ionizing radiation |
4/49 |
75/18903 |
4.23E-05 |
0.0002596 |
9.21E-05 |
HRAS/MDM2/SIRT1/MAPK14 |
4 |
| BP |
GO:0033500 |
carbohydrate homeostasis |
6/49 |
249/18903 |
4.28E-05 |
0.0002621 |
9.30E-05 |
IL6/AKT1/PIK3CA/SIRT1/IGF1R/ACE |
6 |
| BP |
GO:0071456 |
cellular response to hypoxia |
5/49 |
151/18903 |
4.37E-05 |
0.0002664 |
9.46E-05 |
SRC/PTGS2/MDM2/SIRT1/HMOX1 |
5 |
| BP |
GO:0016485 |
protein processing |
6/49 |
250/18903 |
4.38E-05 |
0.0002664 |
9.46E-05 |
SRC/CASP3/CASP1/CASP8/ACE/PLAU |
6 |
| BP |
GO:0060047 |
heart contraction |
6/49 |
250/18903 |
4.38E-05 |
0.0002664 |
9.46E-05 |
TNF/PIK3CA/JAK2/MDM2/ACE/NOS3 |
6 |
| BP |
GO:0048762 |
mesenchymal cell differentiation |
6/49 |
252/18903 |
4.58E-05 |
0.0002773 |
9.84E-05 |
IL6/MAPK3/IGF1/STAT1/MAPK1/HGF |
6 |
| BP |
GO:0050851 |
antigen receptor-mediated signaling pathway |
6/49 |
252/18903 |
4.58E-05 |
0.0002773 |
9.84E-05 |
MAPK1/PIK3CA/HRAS/SYK/LCK/LGALS3 |
6 |
| BP |
GO:0071549 |
cellular response to dexamethasone stimulus |
3/49 |
27/18903 |
4.58E-05 |
0.0002773 |
9.84E-05 |
JAK2/IGF1R/NR3C1 |
3 |
| BP |
GO:0097305 |
response to alcohol |
6/49 |
253/18903 |
4.68E-05 |
0.0002816 |
1.00E-04 |
TNF/AKT1/RHOA/IGF1R/CASP8/ACE |
6 |
| BP |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
4/49 |
77/18903 |
4.69E-05 |
0.0002816 |
1.00E-04 |
TNF/JAK2/CASP8/LCK |
4 |
| BP |
GO:0031279 |
regulation of cyclase activity |
4/49 |
77/18903 |
4.69E-05 |
0.0002816 |
1.00E-04 |
MAPK3/MAPK8/MAPK14/NOS3 |
4 |
| BP |
GO:1903036 |
positive regulation of response to wounding |
4/49 |
77/18903 |
4.69E-05 |
0.0002816 |
1.00E-04 |
HRAS/ITGB1/IGF1R/PLAU |
4 |
| BP |
GO:0045913 |
positive regulation of carbohydrate metabolic process |
4/49 |
78/18903 |
4.94E-05 |
0.0002951 |
0.0001047 |
AKT1/SRC/IGF1/SIRT1 |
4 |
| BP |
GO:0090049 |
regulation of cell migration involved in sprouting angiogenesis |
4/49 |
78/18903 |
4.94E-05 |
0.0002951 |
0.0001047 |
PTGS2/KDR/RHOA/HMOX1 |
4 |
| BP |
GO:0010675 |
regulation of cellular carbohydrate metabolic process |
5/49 |
155/18903 |
4.95E-05 |
0.0002955 |
0.0001049 |
AKT1/SRC/IGF1/SIRT1/NR3C1 |
5 |
| BP |
GO:0008643 |
carbohydrate transport |
5/49 |
156/18903 |
5.11E-05 |
0.0003028 |
0.0001075 |
TNF/AKT1/IGF1/MAPK14/ACE |
5 |
| BP |
GO:0002675 |
positive regulation of acute inflammatory response |
3/49 |
28/18903 |
5.12E-05 |
0.0003028 |
0.0001075 |
TNF/IL6/PTGS2 |
3 |
| BP |
GO:0010758 |
regulation of macrophage chemotaxis |
3/49 |
28/18903 |
5.12E-05 |
0.0003028 |
0.0001075 |
MAPK3/MAPK1/CCL5 |
3 |
| BP |
GO:1903649 |
regulation of cytoplasmic transport |
3/49 |
28/18903 |
5.12E-05 |
0.0003028 |
0.0001075 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0002697 |
regulation of immune effector process |
7/49 |
379/18903 |
5.12E-05 |
0.0003028 |
0.0001075 |
TNF/IL6/KIT/SIRT1/SYK/HMOX1/LGALS3 |
7 |
| BP |
GO:0002437 |
inflammatory response to antigenic stimulus |
4/49 |
79/18903 |
5.19E-05 |
0.0003054 |
0.0001084 |
TNF/SRC/MAPK14/SYK |
4 |
| BP |
GO:0002720 |
positive regulation of cytokine production involved in immune response |
4/49 |
79/18903 |
5.19E-05 |
0.0003054 |
0.0001084 |
IL6/KIT/SIRT1/SYK |
4 |
| BP |
GO:0090316 |
positive regulation of intracellular protein transport |
5/49 |
157/18903 |
5.26E-05 |
0.0003092 |
0.0001098 |
PTGS2/HRAS/JAK2/MAPK8/MAPK14 |
5 |
| BP |
GO:0097530 |
granulocyte migration |
5/49 |
158/18903 |
5.43E-05 |
0.0003181 |
0.0001129 |
MAPK3/MAPK1/CCL5/SYK/LGALS3 |
5 |
| BP |
GO:0002699 |
positive regulation of immune effector process |
6/49 |
261/18903 |
5.56E-05 |
0.0003254 |
0.0001155 |
TNF/IL6/KIT/SIRT1/SYK/HMOX1 |
6 |
| BP |
GO:0035051 |
cardiocyte differentiation |
5/49 |
159/18903 |
5.59E-05 |
0.0003265 |
0.0001159 |
EGFR/MAPK3/IGF1/MAPK1/ITGB1 |
5 |
| BP |
GO:0031668 |
cellular response to extracellular stimulus |
6/49 |
262/18903 |
5.68E-05 |
0.0003311 |
0.0001175 |
MAPK3/MAPK1/MAPK8/SIRT1/IGF1R/HMOX1 |
6 |
| BP |
GO:0097066 |
response to thyroid hormone |
3/49 |
29/18903 |
5.70E-05 |
0.0003311 |
0.0001175 |
KIT/ACE/CTSB |
3 |
| BP |
GO:0097421 |
liver regeneration |
3/49 |
29/18903 |
5.70E-05 |
0.0003311 |
0.0001175 |
TNF/IL6/HMOX1 |
3 |
| BP |
GO:0014855 |
striated muscle cell proliferation |
4/49 |
81/18903 |
5.72E-05 |
0.0003317 |
0.0001177 |
SRC/JAK2/HGF/MAPK14 |
4 |
| BP |
GO:0051147 |
regulation of muscle cell differentiation |
5/49 |
160/18903 |
5.76E-05 |
0.0003332 |
0.0001183 |
IGF1/KIT/MDM2/SIRT1/MAPK14 |
5 |
| BP |
GO:0048708 |
astrocyte differentiation |
4/49 |
82/18903 |
6.01E-05 |
0.0003467 |
0.0001231 |
TNF/IL6/MAPK3/MAPK1 |
4 |
| BP |
GO:0090330 |
regulation of platelet aggregation |
3/49 |
30/18903 |
6.33E-05 |
0.0003644 |
0.0001294 |
IL6/JAK2/SYK |
3 |
| BP |
GO:0051924 |
regulation of calcium ion transport |
6/49 |
268/18903 |
6.44E-05 |
0.0003703 |
0.0001314 |
PTGS2/RHOA/CCL5/ACE/NOS3/LGALS3 |
6 |
| BP |
GO:0097194 |
execution phase of apoptosis |
4/49 |
84/18903 |
6.60E-05 |
0.0003788 |
0.0001345 |
IL6/AKT1/CASP3/CASP8 |
4 |
| BP |
GO:0006606 |
protein import into nucleus |
5/49 |
165/18903 |
6.67E-05 |
0.0003819 |
0.0001356 |
AKT1/PTGS2/JAK2/MAPK14/SYK |
5 |
| BP |
GO:0003018 |
vascular process in circulatory system |
6/49 |
270/18903 |
6.71E-05 |
0.0003836 |
0.0001362 |
TNF/SRC/PTGS2/RHOA/ACE/NOS3 |
6 |
| BP |
GO:0002253 |
activation of immune response |
7/49 |
397/18903 |
6.86E-05 |
0.0003917 |
0.000139 |
SRC/MAPK1/PIK3CA/HRAS/SYK/LCK/LGALS3 |
7 |
| BP |
GO:0045987 |
positive regulation of smooth muscle contraction |
3/49 |
31/18903 |
6.99E-05 |
0.0003974 |
0.0001411 |
PTGS2/RHOA/KIT |
3 |
| BP |
GO:1902042 |
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
3/49 |
31/18903 |
6.99E-05 |
0.0003974 |
0.0001411 |
HGF/HMOX1/NOS3 |
3 |
| BP |
GO:0001959 |
regulation of cytokine-mediated signaling pathway |
5/49 |
167/18903 |
7.06E-05 |
0.0003998 |
0.0001419 |
IL6/CCL5/SYK/CASP1/CASP8 |
5 |
| BP |
GO:0043271 |
negative regulation of ion transport |
5/49 |
167/18903 |
7.06E-05 |
0.0003998 |
0.0001419 |
TNF/MMP9/PTGS2/ACE/NOS3 |
5 |
| BP |
GO:0006970 |
response to osmotic stress |
4/49 |
86/18903 |
7.24E-05 |
0.0004091 |
0.0001452 |
TNF/CASP3/PTGS2/CASP1 |
4 |
| BP |
GO:0051170 |
import into nucleus |
5/49 |
169/18903 |
7.47E-05 |
0.0004214 |
0.0001496 |
AKT1/PTGS2/JAK2/MAPK14/SYK |
5 |
| BP |
GO:0001892 |
embryonic placenta development |
4/49 |
87/18903 |
7.57E-05 |
0.0004248 |
0.0001508 |
AKT1/EGFR/MAPK1/CASP8 |
4 |
| BP |
GO:0010507 |
negative regulation of autophagy |
4/49 |
87/18903 |
7.57E-05 |
0.0004248 |
0.0001508 |
AKT1/PIK3CA/HGF/HMOX1 |
4 |
| BP |
GO:0048145 |
regulation of fibroblast proliferation |
4/49 |
87/18903 |
7.57E-05 |
0.0004248 |
0.0001508 |
EGFR/IGF1/ESR1/HRAS |
4 |
| BP |
GO:0034250 |
positive regulation of cellular amide metabolic process |
5/49 |
170/18903 |
7.68E-05 |
0.0004273 |
0.0001517 |
TNF/IL6/CASP3/RHOA/CCL5 |
5 |
| BP |
GO:0002862 |
negative regulation of inflammatory response to antigenic stimulus |
3/49 |
32/18903 |
7.70E-05 |
0.0004273 |
0.0001517 |
SRC/MAPK14/SYK |
3 |
| BP |
GO:0007435 |
salivary gland morphogenesis |
3/49 |
32/18903 |
7.70E-05 |
0.0004273 |
0.0001517 |
TNF/EGFR/HGF |
3 |
| BP |
GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity |
3/49 |
32/18903 |
7.70E-05 |
0.0004273 |
0.0001517 |
SRC/KIT/FLT1 |
3 |
| BP |
GO:1901889 |
negative regulation of cell junction assembly |
3/49 |
32/18903 |
7.70E-05 |
0.0004273 |
0.0001517 |
TNF/SRC/ACE |
3 |
| BP |
GO:1990776 |
response to angiotensin |
3/49 |
32/18903 |
7.70E-05 |
0.0004273 |
0.0001517 |
SRC/PTGS2/IGF1R |
3 |
| BP |
GO:0045786 |
negative regulation of cell cycle |
7/49 |
405/18903 |
7.78E-05 |
0.0004308 |
0.0001529 |
TNF/CASP3/PTGS2/MDM2/SIRT1/MAPK14/CDK2 |
7 |
| BP |
GO:0033627 |
cell adhesion mediated by integrin |
4/49 |
88/18903 |
7.92E-05 |
0.0004369 |
0.0001551 |
ITGB1/CCL5/SYK/PLAU |
4 |
| BP |
GO:0046889 |
positive regulation of lipid biosynthetic process |
4/49 |
88/18903 |
7.92E-05 |
0.0004369 |
0.0001551 |
TNF/AKT1/PTGS2/IGF1R |
4 |
| BP |
GO:0007254 |
JNK cascade |
5/49 |
172/18903 |
8.12E-05 |
0.0004471 |
0.0001587 |
TNF/EGFR/HRAS/MAPK8/IGF1R |
5 |
| BP |
GO:0038094 |
Fc-gamma receptor signaling pathway |
3/49 |
33/18903 |
8.45E-05 |
0.0004632 |
0.0001644 |
SRC/SYK/LCK |
3 |
| BP |
GO:0045907 |
positive regulation of vasoconstriction |
3/49 |
33/18903 |
8.45E-05 |
0.0004632 |
0.0001644 |
PTGS2/RHOA/ACE |
3 |
| BP |
GO:0050901 |
leukocyte tethering or rolling |
3/49 |
33/18903 |
8.45E-05 |
0.0004632 |
0.0001644 |
TNF/ITGB1/SELE |
3 |
| BP |
GO:0045165 |
cell fate commitment |
6/49 |
282/18903 |
8.53E-05 |
0.0004664 |
0.0001655 |
IL6/CASP3/KDR/RHOA/ITGB1/AR |
6 |
| BP |
GO:0009267 |
cellular response to starvation |
5/49 |
175/18903 |
8.81E-05 |
0.0004798 |
0.0001703 |
MAPK3/MAPK1/MAPK8/SIRT1/IGF1R |
5 |
| BP |
GO:0010469 |
regulation of signaling receptor activity |
5/49 |
175/18903 |
8.81E-05 |
0.0004798 |
0.0001703 |
TNF/SRC/JAK2/ITGB1/PLAU |
5 |
| BP |
GO:0072659 |
protein localization to plasma membrane |
6/49 |
285/18903 |
9.04E-05 |
0.0004917 |
0.0001745 |
TNF/AKT1/EGFR/ITGB1/AR/LGALS3 |
6 |
| BP |
GO:0007431 |
salivary gland development |
3/49 |
34/18903 |
9.26E-05 |
0.0004998 |
0.0001774 |
TNF/EGFR/HGF |
3 |
| BP |
GO:0051450 |
myoblast proliferation |
3/49 |
34/18903 |
9.26E-05 |
0.0004998 |
0.0001774 |
SRC/IGF1/HGF |
3 |
| BP |
GO:0055094 |
response to lipoprotein particle |
3/49 |
34/18903 |
9.26E-05 |
0.0004998 |
0.0001774 |
AKT1/ITGB1/SYK |
3 |
| BP |
GO:0061081 |
positive regulation of myeloid leukocyte cytokine production involved in immune response |
3/49 |
34/18903 |
9.26E-05 |
0.0004998 |
0.0001774 |
KIT/SIRT1/SYK |
3 |
| BP |
GO:0097581 |
lamellipodium organization |
4/49 |
92/18903 |
9.41E-05 |
0.0005074 |
0.0001801 |
SRC/PIK3CA/KIT/ITGB1 |
4 |
| BP |
GO:0001659 |
temperature homeostasis |
5/49 |
178/18903 |
9.54E-05 |
0.0005134 |
0.0001822 |
TNF/PTGS2/JAK2/IGF1R/SYK |
5 |
| BP |
GO:0060759 |
regulation of response to cytokine stimulus |
5/49 |
179/18903 |
9.80E-05 |
0.0005262 |
0.0001868 |
IL6/CCL5/SYK/CASP1/CASP8 |
5 |
| BP |
GO:0070301 |
cellular response to hydrogen peroxide |
4/49 |
93/18903 |
9.82E-05 |
0.0005264 |
0.0001869 |
IL6/SRC/HGF/SIRT1 |
4 |
| BP |
GO:0035265 |
organ growth |
5/49 |
180/18903 |
0.0001006 |
0.0005361 |
0.0001903 |
AKT1/IGF1/ESR1/MAPK14/AR |
5 |
| BP |
GO:0001893 |
maternal placenta development |
3/49 |
35/18903 |
0.0001011 |
0.0005361 |
0.0001903 |
AKT1/PTGS2/CTSB |
3 |
| BP |
GO:0002446 |
neutrophil mediated immunity |
3/49 |
35/18903 |
0.0001011 |
0.0005361 |
0.0001903 |
IL6/SYK/ACE |
3 |
| BP |
GO:0016242 |
negative regulation of macroautophagy |
3/49 |
35/18903 |
0.0001011 |
0.0005361 |
0.0001903 |
AKT1/PIK3CA/HMOX1 |
3 |
| BP |
GO:0035633 |
maintenance of blood-brain barrier |
3/49 |
35/18903 |
0.0001011 |
0.0005361 |
0.0001903 |
IL6/PTGS2/ITGB1 |
3 |
| BP |
GO:0090050 |
positive regulation of cell migration involved in sprouting angiogenesis |
3/49 |
35/18903 |
0.0001011 |
0.0005361 |
0.0001903 |
PTGS2/KDR/HMOX1 |
3 |
| BP |
GO:0090218 |
positive regulation of lipid kinase activity |
3/49 |
36/18903 |
0.00011 |
0.0005827 |
0.0002068 |
SRC/KIT/FLT1 |
3 |
| BP |
GO:0032091 |
negative regulation of protein binding |
4/49 |
96/18903 |
0.0001111 |
0.0005862 |
0.0002081 |
AKT1/MAPK3/MAPK8/ACE |
4 |
| BP |
GO:0061097 |
regulation of protein tyrosine kinase activity |
4/49 |
96/18903 |
0.0001111 |
0.0005862 |
0.0002081 |
EGFR/SRC/CCL5/ACE |
4 |
| BP |
GO:0050728 |
negative regulation of inflammatory response |
5/49 |
184/18903 |
0.0001115 |
0.0005875 |
0.0002085 |
SRC/IGF1/HGF/MAPK14/SYK |
5 |
| BP |
GO:1905952 |
regulation of lipid localization |
5/49 |
185/18903 |
0.0001144 |
0.0006016 |
0.0002135 |
TNF/IL6/AKT1/SIRT1/SYK |
5 |
| BP |
GO:0002690 |
positive regulation of leukocyte chemotaxis |
4/49 |
97/18903 |
0.0001156 |
0.000606 |
0.0002151 |
IL6/MAPK3/MAPK1/CCL5 |
4 |
| BP |
GO:0008593 |
regulation of Notch signaling pathway |
4/49 |
97/18903 |
0.0001156 |
0.000606 |
0.0002151 |
AKT1/SRC/KIT/NOS3 |
4 |
| BP |
GO:0006109 |
regulation of carbohydrate metabolic process |
5/49 |
186/18903 |
0.0001173 |
0.0006138 |
0.0002179 |
AKT1/SRC/IGF1/SIRT1/NR3C1 |
5 |
| BP |
GO:0046326 |
positive regulation of glucose import |
3/49 |
37/18903 |
0.0001195 |
0.000621 |
0.0002204 |
AKT1/IGF1/MAPK14 |
3 |
| BP |
GO:0051385 |
response to mineralocorticoid |
3/49 |
37/18903 |
0.0001195 |
0.000621 |
0.0002204 |
SRC/IGF1R/ACE |
3 |
| BP |
GO:0060416 |
response to growth hormone |
3/49 |
37/18903 |
0.0001195 |
0.000621 |
0.0002204 |
AKT1/JAK2/JAK1 |
3 |
| BP |
GO:0071402 |
cellular response to lipoprotein particle stimulus |
3/49 |
37/18903 |
0.0001195 |
0.000621 |
0.0002204 |
AKT1/ITGB1/SYK |
3 |
| BP |
GO:0032642 |
regulation of chemokine production |
4/49 |
98/18903 |
0.0001203 |
0.000624 |
0.0002215 |
TNF/IL6/SYK/HMOX1 |
4 |
| BP |
GO:0032602 |
chemokine production |
4/49 |
99/18903 |
0.0001252 |
0.000648 |
0.00023 |
TNF/IL6/SYK/HMOX1 |
4 |
| BP |
GO:0050777 |
negative regulation of immune response |
5/49 |
190/18903 |
0.0001296 |
0.00067 |
0.0002378 |
SRC/MAPK14/SYK/HMOX1/LGALS3 |
5 |
| BP |
GO:0002532 |
production of molecular mediator involved in inflammatory response |
4/49 |
100/18903 |
0.0001301 |
0.000671 |
0.0002382 |
TNF/IL6/MAPK14/SYK |
4 |
| BP |
GO:0006816 |
calcium ion transport |
7/49 |
440/18903 |
0.0001303 |
0.000671 |
0.0002382 |
PTGS2/RHOA/CCL5/LCK/ACE/NOS3/LGALS3 |
7 |
| BP |
GO:0007162 |
negative regulation of cell adhesion |
6/49 |
308/18903 |
0.0001382 |
0.0007108 |
0.0002523 |
AKT1/SRC/CASP3/RHOA/JAK2/LGALS3 |
6 |
| BP |
GO:0001990 |
regulation of systemic arterial blood pressure by hormone |
3/49 |
39/18903 |
0.0001401 |
0.000719 |
0.0002552 |
RHOA/ACE/NOS3 |
3 |
| BP |
GO:0009749 |
response to glucose |
5/49 |
194/18903 |
0.0001429 |
0.0007324 |
0.00026 |
CASP3/RHOA/PIK3CA/IGF1R/ACE |
5 |
| BP |
GO:0042063 |
gliogenesis |
6/49 |
310/18903 |
0.0001432 |
0.0007325 |
0.00026 |
TNF/IL6/AKT1/MAPK3/MAPK1/RHOA |
6 |
| BP |
GO:0019233 |
sensory perception of pain |
4/49 |
103/18903 |
0.0001459 |
0.0007413 |
0.0002631 |
TNF/MAPK3/PTGS2/ACE |
4 |
| BP |
GO:0043255 |
regulation of carbohydrate biosynthetic process |
4/49 |
103/18903 |
0.0001459 |
0.0007413 |
0.0002631 |
AKT1/IGF1/SIRT1/NR3C1 |
4 |
| BP |
GO:0045639 |
positive regulation of myeloid cell differentiation |
4/49 |
103/18903 |
0.0001459 |
0.0007413 |
0.0002631 |
TNF/STAT1/MAPK14/CASP8 |
4 |
| BP |
GO:0048144 |
fibroblast proliferation |
4/49 |
103/18903 |
0.0001459 |
0.0007413 |
0.0002631 |
EGFR/IGF1/ESR1/HRAS |
4 |
| BP |
GO:0042307 |
positive regulation of protein import into nucleus |
3/49 |
40/18903 |
0.0001512 |
0.0007655 |
0.0002717 |
PTGS2/JAK2/MAPK14 |
3 |
| BP |
GO:0071392 |
cellular response to estradiol stimulus |
3/49 |
40/18903 |
0.0001512 |
0.0007655 |
0.0002717 |
EGFR/ESR1/IGF1R |
3 |
| BP |
GO:0032388 |
positive regulation of intracellular transport |
5/49 |
199/18903 |
0.000161 |
0.0008138 |
0.0002888 |
PTGS2/HRAS/JAK2/MAPK8/MAPK14 |
5 |
| BP |
GO:0051960 |
regulation of nervous system development |
7/49 |
456/18903 |
0.0001624 |
0.0008162 |
0.0002897 |
TNF/IL6/AKT1/KIT/ITGB1/HGF/ACE |
7 |
| BP |
GO:0032733 |
positive regulation of interleukin-10 production |
3/49 |
41/18903 |
0.0001628 |
0.0008162 |
0.0002897 |
IL6/HGF/SYK |
3 |
| BP |
GO:0042119 |
neutrophil activation |
3/49 |
41/18903 |
0.0001628 |
0.0008162 |
0.0002897 |
TNF/CCL5/SYK |
3 |
| BP |
GO:0045124 |
regulation of bone resorption |
3/49 |
41/18903 |
0.0001628 |
0.0008162 |
0.0002897 |
IL6/SRC/SYK |
3 |
| BP |
GO:0050850 |
positive regulation of calcium-mediated signaling |
3/49 |
41/18903 |
0.0001628 |
0.0008162 |
0.0002897 |
TNF/IGF1/SYK |
3 |
| BP |
GO:0030198 |
extracellular matrix organization |
6/49 |
318/18903 |
0.0001645 |
0.0008231 |
0.0002922 |
TNF/IL6/MMP9/ITGB1/MMP3/MMP1 |
6 |
| BP |
GO:0043062 |
extracellular structure organization |
6/49 |
319/18903 |
0.0001673 |
0.0008359 |
0.0002967 |
TNF/IL6/MMP9/ITGB1/MMP3/MMP1 |
6 |
| BP |
GO:0045229 |
external encapsulating structure organization |
6/49 |
321/18903 |
0.0001731 |
0.0008633 |
0.0003064 |
TNF/IL6/MMP9/ITGB1/MMP3/MMP1 |
6 |
| BP |
GO:0045022 |
early endosome to late endosome transport |
3/49 |
42/18903 |
0.000175 |
0.0008701 |
0.0003089 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0050999 |
regulation of nitric-oxide synthase activity |
3/49 |
42/18903 |
0.000175 |
0.0008701 |
0.0003089 |
TNF/AKT1/EGFR |
3 |
| BP |
GO:0008202 |
steroid metabolic process |
6/49 |
323/18903 |
0.000179 |
0.0008884 |
0.0003153 |
TNF/ESR1/KIT/SIRT1/IGF1R/NR3C1 |
6 |
| BP |
GO:1901888 |
regulation of cell junction assembly |
5/49 |
204/18903 |
0.0001807 |
0.0008955 |
0.0003179 |
TNF/SRC/KDR/RHOA/ACE |
5 |
| BP |
GO:0042116 |
macrophage activation |
4/49 |
109/18903 |
0.0001815 |
0.0008979 |
0.0003187 |
TNF/IL6/JAK2/SYK |
4 |
| BP |
GO:0033574 |
response to testosterone |
3/49 |
43/18903 |
0.0001878 |
0.000926 |
0.0003287 |
SIRT1/IGF1R/AR |
3 |
| BP |
GO:1904037 |
positive regulation of epithelial cell apoptotic process |
3/49 |
43/18903 |
0.0001878 |
0.000926 |
0.0003287 |
IL6/JAK2/HMOX1 |
3 |
| BP |
GO:2000241 |
regulation of reproductive process |
5/49 |
206/18903 |
0.0001891 |
0.0009309 |
0.0003304 |
SRC/IGF1/ESR1/KIT/AR |
5 |
| BP |
GO:0048167 |
regulation of synaptic plasticity |
5/49 |
207/18903 |
0.0001934 |
0.0009506 |
0.0003374 |
PTGS2/MAPK1/KIT/HRAS/ACE |
5 |
| BP |
GO:0019722 |
calcium-mediated signaling |
5/49 |
208/18903 |
0.0001978 |
0.0009705 |
0.0003445 |
TNF/IGF1/KDR/SYK/SELE |
5 |
| BP |
GO:0010828 |
positive regulation of glucose transmembrane transport |
3/49 |
44/18903 |
0.0002012 |
0.0009822 |
0.0003486 |
AKT1/IGF1/MAPK14 |
3 |
| BP |
GO:0014911 |
positive regulation of smooth muscle cell migration |
3/49 |
44/18903 |
0.0002012 |
0.0009822 |
0.0003486 |
SRC/IGF1/CCL5 |
3 |
| BP |
GO:1905521 |
regulation of macrophage migration |
3/49 |
44/18903 |
0.0002012 |
0.0009822 |
0.0003486 |
MAPK3/MAPK1/CCL5 |
3 |
| BP |
GO:0045445 |
myoblast differentiation |
4/49 |
112/18903 |
0.0002015 |
0.0009822 |
0.0003486 |
TNF/IGF1/ITGB1/MAPK14 |
4 |
| BP |
GO:0002440 |
production of molecular mediator of immune response |
6/49 |
333/18903 |
0.000211 |
0.0010272 |
0.0003646 |
TNF/IL6/KIT/SIRT1/SYK/HMOX1 |
6 |
| BP |
GO:0042594 |
response to starvation |
5/49 |
211/18903 |
0.0002114 |
0.0010272 |
0.0003646 |
MAPK3/MAPK1/MAPK8/SIRT1/IGF1R |
5 |
| BP |
GO:0008631 |
intrinsic apoptotic signaling pathway in response to oxidative stress |
3/49 |
45/18903 |
0.0002151 |
0.0010405 |
0.0003693 |
AKT1/JAK2/SIRT1 |
3 |
| BP |
GO:0098927 |
vesicle-mediated transport between endosomal compartments |
3/49 |
45/18903 |
0.0002151 |
0.0010405 |
0.0003693 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:1904646 |
cellular response to amyloid-beta |
3/49 |
45/18903 |
0.0002151 |
0.0010405 |
0.0003693 |
TNF/IGF1/IGF1R |
3 |
| BP |
GO:0051604 |
protein maturation |
6/49 |
336/18903 |
0.0002215 |
0.0010695 |
0.0003796 |
SRC/CASP3/CASP1/CASP8/ACE/PLAU |
6 |
| BP |
GO:0001938 |
positive regulation of endothelial cell proliferation |
4/49 |
115/18903 |
0.000223 |
0.001075 |
0.0003816 |
AKT1/KDR/SIRT1/HMOX1 |
4 |
| BP |
GO:0035272 |
exocrine system development |
3/49 |
46/18903 |
0.0002297 |
0.0011057 |
0.0003925 |
TNF/EGFR/HGF |
3 |
| BP |
GO:0010876 |
lipid localization |
7/49 |
483/18903 |
0.000231 |
0.0011084 |
0.0003934 |
TNF/IL6/AKT1/PTGS2/SIRT1/SYK/ACE |
7 |
| BP |
GO:0022411 |
cellular component disassembly |
7/49 |
483/18903 |
0.000231 |
0.0011084 |
0.0003934 |
TNF/IL6/MMP9/PIK3CA/IGF1R/MMP3/MMP1 |
7 |
| BP |
GO:0000079 |
regulation of cyclin-dependent protein serine/threonine kinase activity |
4/49 |
117/18903 |
0.0002382 |
0.0011411 |
0.000405 |
AKT1/EGFR/SRC/CASP3 |
4 |
| BP |
GO:0001774 |
microglial cell activation |
3/49 |
47/18903 |
0.0002449 |
0.0011604 |
0.0004119 |
TNF/IL6/JAK2 |
3 |
| BP |
GO:0030521 |
androgen receptor signaling pathway |
3/49 |
47/18903 |
0.0002449 |
0.0011604 |
0.0004119 |
RHOA/SIRT1/AR |
3 |
| BP |
GO:0036230 |
granulocyte activation |
3/49 |
47/18903 |
0.0002449 |
0.0011604 |
0.0004119 |
TNF/CCL5/SYK |
3 |
| BP |
GO:0048286 |
lung alveolus development |
3/49 |
47/18903 |
0.0002449 |
0.0011604 |
0.0004119 |
KDR/ACE/PGR |
3 |
| BP |
GO:0051972 |
regulation of telomerase activity |
3/49 |
47/18903 |
0.0002449 |
0.0011604 |
0.0004119 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0060711 |
labyrinthine layer development |
3/49 |
47/18903 |
0.0002449 |
0.0011604 |
0.0004119 |
AKT1/MAPK1/CASP8 |
3 |
| BP |
GO:0071470 |
cellular response to osmotic stress |
3/49 |
47/18903 |
0.0002449 |
0.0011604 |
0.0004119 |
CASP3/PTGS2/CASP1 |
3 |
| BP |
GO:0015718 |
monocarboxylic acid transport |
4/49 |
119/18903 |
0.0002542 |
0.0012023 |
0.0004268 |
TNF/PTGS2/SYK/ACE |
4 |
| BP |
GO:0001974 |
blood vessel remodeling |
3/49 |
48/18903 |
0.0002608 |
0.0012164 |
0.0004318 |
MDM2/ACE/NOS3 |
3 |
| BP |
GO:0002673 |
regulation of acute inflammatory response |
3/49 |
48/18903 |
0.0002608 |
0.0012164 |
0.0004318 |
TNF/IL6/PTGS2 |
3 |
| BP |
GO:0006953 |
acute-phase response |
3/49 |
48/18903 |
0.0002608 |
0.0012164 |
0.0004318 |
TNF/IL6/PTGS2 |
3 |
| BP |
GO:0031641 |
regulation of myelination |
3/49 |
48/18903 |
0.0002608 |
0.0012164 |
0.0004318 |
TNF/AKT1/HGF |
3 |
| BP |
GO:0031648 |
protein destabilization |
3/49 |
48/18903 |
0.0002608 |
0.0012164 |
0.0004318 |
SRC/MDM2/SIRT1 |
3 |
| BP |
GO:0032309 |
icosanoid secretion |
3/49 |
48/18903 |
0.0002608 |
0.0012164 |
0.0004318 |
PTGS2/SYK/ACE |
3 |
| BP |
GO:0045747 |
positive regulation of Notch signaling pathway |
3/49 |
48/18903 |
0.0002608 |
0.0012164 |
0.0004318 |
SRC/KIT/NOS3 |
3 |
| BP |
GO:0046850 |
regulation of bone remodeling |
3/49 |
48/18903 |
0.0002608 |
0.0012164 |
0.0004318 |
IL6/SRC/SYK |
3 |
| BP |
GO:1902003 |
regulation of amyloid-beta formation |
3/49 |
48/18903 |
0.0002608 |
0.0012164 |
0.0004318 |
TNF/CASP3/IGF1 |
3 |
| BP |
GO:0002821 |
positive regulation of adaptive immune response |
4/49 |
120/18903 |
0.0002624 |
0.0012203 |
0.0004332 |
TNF/IL6/JAK2/SIRT1 |
4 |
| BP |
GO:1904029 |
regulation of cyclin-dependent protein kinase activity |
4/49 |
120/18903 |
0.0002624 |
0.0012203 |
0.0004332 |
AKT1/EGFR/SRC/CASP3 |
4 |
| BP |
GO:0010810 |
regulation of cell-substrate adhesion |
5/49 |
222/18903 |
0.0002674 |
0.0012415 |
0.0004407 |
SRC/KDR/RHOA/JAK2/PLAU |
5 |
| BP |
GO:0042113 |
B cell activation |
6/49 |
350/18903 |
0.0002758 |
0.0012756 |
0.0004528 |
IL6/CASP3/KIT/ITGB1/SYK/CASP8 |
6 |
| BP |
GO:0003044 |
regulation of systemic arterial blood pressure mediated by a chemical signal |
3/49 |
49/18903 |
0.0002773 |
0.0012756 |
0.0004528 |
RHOA/ACE/NOS3 |
3 |
| BP |
GO:0033628 |
regulation of cell adhesion mediated by integrin |
3/49 |
49/18903 |
0.0002773 |
0.0012756 |
0.0004528 |
CCL5/SYK/PLAU |
3 |
| BP |
GO:0034198 |
cellular response to amino acid starvation |
3/49 |
49/18903 |
0.0002773 |
0.0012756 |
0.0004528 |
MAPK3/MAPK1/MAPK8 |
3 |
| BP |
GO:0043457 |
regulation of cellular respiration |
3/49 |
49/18903 |
0.0002773 |
0.0012756 |
0.0004528 |
TNF/RHOA/PIK3CA |
3 |
| BP |
GO:0045933 |
positive regulation of muscle contraction |
3/49 |
49/18903 |
0.0002773 |
0.0012756 |
0.0004528 |
PTGS2/RHOA/KIT |
3 |
| BP |
GO:0031346 |
positive regulation of cell projection organization |
6/49 |
352/18903 |
0.0002844 |
0.0013047 |
0.0004631 |
SRC/PIK3CA/KIT/HRAS/HGF/IGF1R |
6 |
| BP |
GO:0033157 |
regulation of intracellular protein transport |
5/49 |
225/18903 |
0.0002845 |
0.0013047 |
0.0004631 |
PTGS2/HRAS/JAK2/MAPK8/MAPK14 |
5 |
| BP |
GO:0097237 |
cellular response to toxic substance |
4/49 |
123/18903 |
0.0002884 |
0.0013202 |
0.0004686 |
TNF/PTGS2/MPO/NOS3 |
4 |
| BP |
GO:0007265 |
Ras protein signal transduction |
6/49 |
353/18903 |
0.0002887 |
0.0013202 |
0.0004686 |
SRC/IGF1/RHOA/HRAS/ITGB1/CDK2 |
6 |
| BP |
GO:0002676 |
regulation of chronic inflammatory response |
2/49 |
10/18903 |
0.0002923 |
0.0013284 |
0.0004715 |
TNF/CCL5 |
2 |
| BP |
GO:0032025 |
response to cobalt ion |
2/49 |
10/18903 |
0.0002923 |
0.0013284 |
0.0004715 |
CASP3/CASP8 |
2 |
| BP |
GO:0032070 |
regulation of deoxyribonuclease activity |
2/49 |
10/18903 |
0.0002923 |
0.0013284 |
0.0004715 |
AKT1/SIRT1 |
2 |
| BP |
GO:0060397 |
growth hormone receptor signaling pathway via JAK-STAT |
2/49 |
10/18903 |
0.0002923 |
0.0013284 |
0.0004715 |
JAK2/JAK1 |
2 |
| BP |
GO:0002066 |
columnar/cuboidal epithelial cell development |
3/49 |
50/18903 |
0.0002945 |
0.0013302 |
0.0004722 |
AKT1/SRC/PGR |
3 |
| BP |
GO:0002269 |
leukocyte activation involved in inflammatory response |
3/49 |
50/18903 |
0.0002945 |
0.0013302 |
0.0004722 |
TNF/IL6/JAK2 |
3 |
| BP |
GO:0038084 |
vascular endothelial growth factor signaling pathway |
3/49 |
50/18903 |
0.0002945 |
0.0013302 |
0.0004722 |
KDR/PIK3CA/FLT1 |
3 |
| BP |
GO:0045737 |
positive regulation of cyclin-dependent protein serine/threonine kinase activity |
3/49 |
50/18903 |
0.0002945 |
0.0013302 |
0.0004722 |
AKT1/EGFR/SRC |
3 |
| BP |
GO:0001952 |
regulation of cell-matrix adhesion |
4/49 |
125/18903 |
0.0003067 |
0.0013834 |
0.000491 |
SRC/KDR/RHOA/PLAU |
4 |
| BP |
GO:0030225 |
macrophage differentiation |
3/49 |
51/18903 |
0.0003123 |
0.0013982 |
0.0004963 |
MMP9/SIRT1/CASP8 |
3 |
| BP |
GO:0045058 |
T cell selection |
3/49 |
51/18903 |
0.0003123 |
0.0013982 |
0.0004963 |
IL6/RHOA/SYK |
3 |
| BP |
GO:0050873 |
brown fat cell differentiation |
3/49 |
51/18903 |
0.0003123 |
0.0013982 |
0.0004963 |
PTGS2/SIRT1/MAPK14 |
3 |
| BP |
GO:0060425 |
lung morphogenesis |
3/49 |
51/18903 |
0.0003123 |
0.0013982 |
0.0004963 |
TNF/MAPK3/MAPK1 |
3 |
| BP |
GO:1990928 |
response to amino acid starvation |
3/49 |
51/18903 |
0.0003123 |
0.0013982 |
0.0004963 |
MAPK3/MAPK1/MAPK8 |
3 |
| BP |
GO:0050920 |
regulation of chemotaxis |
5/49 |
230/18903 |
0.0003148 |
0.0014072 |
0.0004995 |
IL6/MAPK3/KDR/MAPK1/CCL5 |
5 |
| BP |
GO:0006690 |
icosanoid metabolic process |
4/49 |
126/18903 |
0.0003162 |
0.0014113 |
0.0005009 |
PTGS2/SIRT1/SYK/CASP1 |
4 |
| BP |
GO:0001655 |
urogenital system development |
6/49 |
360/18903 |
0.0003207 |
0.0014292 |
0.0005073 |
MMP9/ESR1/STAT1/RHOA/ACE/AR |
6 |
| BP |
GO:0050769 |
positive regulation of neurogenesis |
5/49 |
231/18903 |
0.0003211 |
0.0014292 |
0.0005073 |
TNF/IL6/KIT/ITGB1/ACE |
5 |
| BP |
GO:0002831 |
regulation of response to biotic stimulus |
6/49 |
361/18903 |
0.0003255 |
0.0014458 |
0.0005132 |
SRC/MAPK3/STAT1/CCL5/SYK/CASP8 |
6 |
| BP |
GO:0002688 |
regulation of leukocyte chemotaxis |
4/49 |
127/18903 |
0.0003258 |
0.0014458 |
0.0005132 |
IL6/MAPK3/MAPK1/CCL5 |
4 |
| BP |
GO:0010823 |
negative regulation of mitochondrion organization |
3/49 |
52/18903 |
0.0003308 |
0.0014594 |
0.000518 |
AKT1/IGF1/HGF |
3 |
| BP |
GO:0043303 |
mast cell degranulation |
3/49 |
52/18903 |
0.0003308 |
0.0014594 |
0.000518 |
KIT/SYK/HMOX1 |
3 |
| BP |
GO:0046622 |
positive regulation of organ growth |
3/49 |
52/18903 |
0.0003308 |
0.0014594 |
0.000518 |
AKT1/IGF1/MAPK14 |
3 |
| BP |
GO:0060612 |
adipose tissue development |
3/49 |
52/18903 |
0.0003308 |
0.0014594 |
0.000518 |
PIK3CA/HRAS/SIRT1 |
3 |
| BP |
GO:0045471 |
response to ethanol |
4/49 |
128/18903 |
0.0003357 |
0.0014787 |
0.0005249 |
TNF/RHOA/IGF1R/CASP8 |
4 |
| BP |
GO:2000027 |
regulation of animal organ morphogenesis |
4/49 |
129/18903 |
0.0003458 |
0.0015209 |
0.0005399 |
TNF/RHOA/HGF/AR |
4 |
| BP |
GO:0032210 |
regulation of telomere maintenance via telomerase |
3/49 |
53/18903 |
0.00035 |
0.0015352 |
0.0005449 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0071622 |
regulation of granulocyte chemotaxis |
3/49 |
53/18903 |
0.00035 |
0.0015352 |
0.0005449 |
MAPK3/MAPK1/CCL5 |
3 |
| BP |
GO:0001660 |
fever generation |
2/49 |
11/18903 |
0.0003567 |
0.001553 |
0.0005512 |
TNF/PTGS2 |
2 |
| BP |
GO:0060020 |
Bergmann glial cell differentiation |
2/49 |
11/18903 |
0.0003567 |
0.001553 |
0.0005512 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0060439 |
trachea morphogenesis |
2/49 |
11/18903 |
0.0003567 |
0.001553 |
0.0005512 |
MAPK3/MAPK1 |
2 |
| BP |
GO:1901731 |
positive regulation of platelet aggregation |
2/49 |
11/18903 |
0.0003567 |
0.001553 |
0.0005512 |
IL6/JAK2 |
2 |
| BP |
GO:1901856 |
negative regulation of cellular respiration |
2/49 |
11/18903 |
0.0003567 |
0.001553 |
0.0005512 |
TNF/RHOA |
2 |
| BP |
GO:0031589 |
cell-substrate adhesion |
6/49 |
369/18903 |
0.0003658 |
0.0015904 |
0.0005645 |
SRC/KDR/RHOA/JAK2/ITGB1/PLAU |
6 |
| BP |
GO:0007160 |
cell-matrix adhesion |
5/49 |
238/18903 |
0.0003683 |
0.0015924 |
0.0005652 |
SRC/KDR/RHOA/ITGB1/PLAU |
5 |
| BP |
GO:0002279 |
mast cell activation involved in immune response |
3/49 |
54/18903 |
0.00037 |
0.0015924 |
0.0005652 |
KIT/SYK/HMOX1 |
3 |
| BP |
GO:0010883 |
regulation of lipid storage |
3/49 |
54/18903 |
0.00037 |
0.0015924 |
0.0005652 |
TNF/IL6/SIRT1 |
3 |
| BP |
GO:0030520 |
intracellular estrogen receptor signaling pathway |
3/49 |
54/18903 |
0.00037 |
0.0015924 |
0.0005652 |
SRC/ESR1/AR |
3 |
| BP |
GO:0050819 |
negative regulation of coagulation |
3/49 |
54/18903 |
0.00037 |
0.0015924 |
0.0005652 |
ANXA5/NOS3/PLAU |
3 |
| BP |
GO:0061900 |
glial cell activation |
3/49 |
54/18903 |
0.00037 |
0.0015924 |
0.0005652 |
TNF/IL6/JAK2 |
3 |
| BP |
GO:1904031 |
positive regulation of cyclin-dependent protein kinase activity |
3/49 |
54/18903 |
0.00037 |
0.0015924 |
0.0005652 |
AKT1/EGFR/SRC |
3 |
| BP |
GO:0048565 |
digestive tract development |
4/49 |
132/18903 |
0.0003773 |
0.0016219 |
0.0005757 |
TNF/EGFR/SRC/KIT |
4 |
| BP |
GO:0002244 |
hematopoietic progenitor cell differentiation |
4/49 |
133/18903 |
0.0003883 |
0.0016552 |
0.0005875 |
KDR/KIT/ACE/FLT1 |
4 |
| BP |
GO:0002702 |
positive regulation of production of molecular mediator of immune response |
4/49 |
133/18903 |
0.0003883 |
0.0016552 |
0.0005875 |
IL6/KIT/SIRT1/SYK |
4 |
| BP |
GO:0035303 |
regulation of dephosphorylation |
4/49 |
133/18903 |
0.0003883 |
0.0016552 |
0.0005875 |
TNF/SRC/JAK2/LGALS3 |
4 |
| BP |
GO:0002703 |
regulation of leukocyte mediated immunity |
5/49 |
241/18903 |
0.00039 |
0.0016552 |
0.0005875 |
TNF/IL6/KIT/SYK/HMOX1 |
5 |
| BP |
GO:0042445 |
hormone metabolic process |
5/49 |
241/18903 |
0.00039 |
0.0016552 |
0.0005875 |
ESR1/IGF1R/ACE/CTSB/NR3C1 |
5 |
| BP |
GO:0002448 |
mast cell mediated immunity |
3/49 |
55/18903 |
0.0003906 |
0.0016552 |
0.0005875 |
KIT/SYK/HMOX1 |
3 |
| BP |
GO:0071385 |
cellular response to glucocorticoid stimulus |
3/49 |
55/18903 |
0.0003906 |
0.0016552 |
0.0005875 |
JAK2/IGF1R/NR3C1 |
3 |
| BP |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
3/49 |
55/18903 |
0.0003906 |
0.0016552 |
0.0005875 |
AKT1/EGFR/MDM2 |
3 |
| BP |
GO:1902991 |
regulation of amyloid precursor protein catabolic process |
3/49 |
55/18903 |
0.0003906 |
0.0016552 |
0.0005875 |
TNF/CASP3/IGF1 |
3 |
| BP |
GO:1903202 |
negative regulation of oxidative stress-induced cell death |
3/49 |
55/18903 |
0.0003906 |
0.0016552 |
0.0005875 |
AKT1/HGF/SIRT1 |
3 |
| BP |
GO:2001235 |
positive regulation of apoptotic signaling pathway |
4/49 |
135/18903 |
0.0004109 |
0.0017335 |
0.0006153 |
TNF/JAK2/SIRT1/LCK |
4 |
| BP |
GO:0034205 |
amyloid-beta formation |
3/49 |
56/18903 |
0.0004119 |
0.0017335 |
0.0006153 |
TNF/CASP3/IGF1 |
3 |
| BP |
GO:0043551 |
regulation of phosphatidylinositol 3-kinase activity |
3/49 |
56/18903 |
0.0004119 |
0.0017335 |
0.0006153 |
SRC/KIT/FLT1 |
3 |
| BP |
GO:0071715 |
icosanoid transport |
3/49 |
56/18903 |
0.0004119 |
0.0017335 |
0.0006153 |
PTGS2/SYK/ACE |
3 |
| BP |
GO:2000630 |
positive regulation of miRNA metabolic process |
3/49 |
56/18903 |
0.0004119 |
0.0017335 |
0.0006153 |
TNF/HRAS/NR3C1 |
3 |
| BP |
GO:0031650 |
regulation of heat generation |
2/49 |
12/18903 |
0.0004273 |
0.0017882 |
0.0006347 |
TNF/PTGS2 |
2 |
| BP |
GO:0060736 |
prostate gland growth |
2/49 |
12/18903 |
0.0004273 |
0.0017882 |
0.0006347 |
ESR1/AR |
2 |
| BP |
GO:0061517 |
macrophage proliferation |
2/49 |
12/18903 |
0.0004273 |
0.0017882 |
0.0006347 |
MAPK3/MAPK1 |
2 |
| BP |
GO:1903800 |
positive regulation of miRNA maturation |
2/49 |
12/18903 |
0.0004273 |
0.0017882 |
0.0006347 |
IL6/EGFR |
2 |
| BP |
GO:0032768 |
regulation of monooxygenase activity |
3/49 |
57/18903 |
0.000434 |
0.0018088 |
0.000642 |
TNF/AKT1/EGFR |
3 |
| BP |
GO:0043388 |
positive regulation of DNA binding |
3/49 |
57/18903 |
0.000434 |
0.0018088 |
0.000642 |
MMP9/IGF1/JAK2 |
3 |
| BP |
GO:0070231 |
T cell apoptotic process |
3/49 |
57/18903 |
0.000434 |
0.0018088 |
0.000642 |
AKT1/CCL5/LGALS3 |
3 |
| BP |
GO:0031330 |
negative regulation of cellular catabolic process |
5/49 |
247/18903 |
0.0004364 |
0.0018162 |
0.0006446 |
AKT1/PIK3CA/HGF/MAPK14/HMOX1 |
5 |
| BP |
GO:0010803 |
regulation of tumor necrosis factor-mediated signaling pathway |
3/49 |
58/18903 |
0.0004569 |
0.0018987 |
0.000674 |
SYK/CASP1/CASP8 |
3 |
| BP |
GO:0000082 |
G1/S transition of mitotic cell cycle |
5/49 |
250/18903 |
0.0004611 |
0.001911 |
0.0006783 |
AKT1/EGFR/ITGB1/MDM2/CDK2 |
5 |
| BP |
GO:0009636 |
response to toxic substance |
5/49 |
250/18903 |
0.0004611 |
0.001911 |
0.0006783 |
TNF/PTGS2/CCL5/MPO/NOS3 |
5 |
| BP |
GO:0042306 |
regulation of protein import into nucleus |
3/49 |
59/18903 |
0.0004805 |
0.0019859 |
0.0007049 |
PTGS2/JAK2/MAPK14 |
3 |
| BP |
GO:0043666 |
regulation of phosphoprotein phosphatase activity |
3/49 |
59/18903 |
0.0004805 |
0.0019859 |
0.0007049 |
TNF/JAK2/LGALS3 |
3 |
| BP |
GO:0045667 |
regulation of osteoblast differentiation |
4/49 |
141/18903 |
0.0004844 |
0.0019965 |
0.0007087 |
TNF/IL6/IGF1/HGF |
4 |
| BP |
GO:0046328 |
regulation of JNK cascade |
4/49 |
141/18903 |
0.0004844 |
0.0019965 |
0.0007087 |
TNF/EGFR/HRAS/IGF1R |
4 |
| BP |
GO:0007178 |
transmembrane receptor protein serine/threonine kinase signaling pathway |
6/49 |
390/18903 |
0.0004905 |
0.0020189 |
0.0007166 |
SRC/MAPK3/KDR/JAK2/SIRT1/MAPK14 |
6 |
| BP |
GO:0038061 |
NIK/NF-kappaB signaling |
4/49 |
142/18903 |
0.0004975 |
0.0020449 |
0.0007258 |
TNF/AKT1/EGFR/RHOA |
4 |
| BP |
GO:0003084 |
positive regulation of systemic arterial blood pressure |
2/49 |
13/18903 |
0.0005042 |
0.0020611 |
0.0007316 |
RHOA/ACE |
2 |
| BP |
GO:0031392 |
regulation of prostaglandin biosynthetic process |
2/49 |
13/18903 |
0.0005042 |
0.0020611 |
0.0007316 |
PTGS2/SIRT1 |
2 |
| BP |
GO:0043568 |
positive regulation of insulin-like growth factor receptor signaling pathway |
2/49 |
13/18903 |
0.0005042 |
0.0020611 |
0.0007316 |
IGF1/AR |
2 |
| BP |
GO:0071389 |
cellular response to mineralocorticoid stimulus |
2/49 |
13/18903 |
0.0005042 |
0.0020611 |
0.0007316 |
IGF1R/ACE |
2 |
| BP |
GO:0045599 |
negative regulation of fat cell differentiation |
3/49 |
60/18903 |
0.0005049 |
0.0020611 |
0.0007316 |
TNF/IL6/SIRT1 |
3 |
| BP |
GO:0045727 |
positive regulation of translation |
4/49 |
143/18903 |
0.0005108 |
0.0020799 |
0.0007383 |
TNF/IL6/RHOA/CCL5 |
4 |
| BP |
GO:0055123 |
digestive system development |
4/49 |
143/18903 |
0.0005108 |
0.0020799 |
0.0007383 |
TNF/EGFR/SRC/KIT |
4 |
| BP |
GO:0090257 |
regulation of muscle system process |
5/49 |
256/18903 |
0.0005137 |
0.0020886 |
0.0007413 |
PTGS2/IGF1/RHOA/KIT/NOS3 |
5 |
| BP |
GO:0050708 |
regulation of protein secretion |
5/49 |
257/18903 |
0.0005228 |
0.002123 |
0.0007536 |
TNF/IL6/IGF1/JAK2/CCL5 |
5 |
| BP |
GO:0010508 |
positive regulation of autophagy |
4/49 |
144/18903 |
0.0005244 |
0.0021266 |
0.0007548 |
MAPK3/KDR/SIRT1/HMOX1 |
4 |
| BP |
GO:0034113 |
heterotypic cell-cell adhesion |
3/49 |
61/18903 |
0.00053 |
0.0021435 |
0.0007608 |
TNF/ITGB1/LCK |
3 |
| BP |
GO:1904356 |
regulation of telomere maintenance via telomere lengthening |
3/49 |
61/18903 |
0.00053 |
0.0021435 |
0.0007608 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0031644 |
regulation of nervous system process |
4/49 |
145/18903 |
0.0005383 |
0.002174 |
0.0007717 |
TNF/SRC/HGF/NOS3 |
4 |
| BP |
GO:0031102 |
neuron projection regeneration |
3/49 |
62/18903 |
0.0005559 |
0.0022334 |
0.0007928 |
JAK2/HGF/IGF1R |
3 |
| BP |
GO:0046824 |
positive regulation of nucleocytoplasmic transport |
3/49 |
62/18903 |
0.0005559 |
0.0022334 |
0.0007928 |
PTGS2/JAK2/MAPK14 |
3 |
| BP |
GO:0090303 |
positive regulation of wound healing |
3/49 |
62/18903 |
0.0005559 |
0.0022334 |
0.0007928 |
HRAS/ITGB1/PLAU |
3 |
| BP |
GO:1904036 |
negative regulation of epithelial cell apoptotic process |
3/49 |
62/18903 |
0.0005559 |
0.0022334 |
0.0007928 |
KDR/IGF1R/HMOX1 |
3 |
| BP |
GO:0045927 |
positive regulation of growth |
5/49 |
261/18903 |
0.0005608 |
0.0022499 |
0.0007986 |
AKT1/EGFR/IGF1/RHOA/MAPK14 |
5 |
| BP |
GO:0008584 |
male gonad development |
4/49 |
147/18903 |
0.0005668 |
0.0022708 |
0.000806 |
ESR1/KIT/ACE/AR |
4 |
| BP |
GO:0046546 |
development of primary male sexual characteristics |
4/49 |
148/18903 |
0.0005814 |
0.0023161 |
0.0008221 |
ESR1/KIT/ACE/AR |
4 |
| BP |
GO:0010573 |
vascular endothelial growth factor production |
3/49 |
63/18903 |
0.0005827 |
0.0023161 |
0.0008221 |
TNF/IL6/PTGS2 |
3 |
| BP |
GO:0032481 |
positive regulation of type I interferon production |
3/49 |
63/18903 |
0.0005827 |
0.0023161 |
0.0008221 |
GAPDH/STAT1/SYK |
3 |
| BP |
GO:0032757 |
positive regulation of interleukin-8 production |
3/49 |
63/18903 |
0.0005827 |
0.0023161 |
0.0008221 |
TNF/IL6/SYK |
3 |
| BP |
GO:0045453 |
bone resorption |
3/49 |
63/18903 |
0.0005827 |
0.0023161 |
0.0008221 |
IL6/SRC/SYK |
3 |
| BP |
GO:0070542 |
response to fatty acid |
3/49 |
63/18903 |
0.0005827 |
0.0023161 |
0.0008221 |
SRC/PTGS2/PIK3CA |
3 |
| BP |
GO:0031958 |
corticosteroid receptor signaling pathway |
2/49 |
14/18903 |
0.0005872 |
0.0023219 |
0.0008242 |
JAK2/NR3C1 |
2 |
| BP |
GO:0045348 |
positive regulation of MHC class II biosynthetic process |
2/49 |
14/18903 |
0.0005872 |
0.0023219 |
0.0008242 |
JAK2/SIRT1 |
2 |
| BP |
GO:0070572 |
positive regulation of neuron projection regeneration |
2/49 |
14/18903 |
0.0005872 |
0.0023219 |
0.0008242 |
HGF/IGF1R |
2 |
| BP |
GO:1904044 |
response to aldosterone |
2/49 |
14/18903 |
0.0005872 |
0.0023219 |
0.0008242 |
IGF1R/ACE |
2 |
| BP |
GO:0050796 |
regulation of insulin secretion |
4/49 |
149/18903 |
0.0005963 |
0.0023548 |
0.0008358 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0019229 |
regulation of vasoconstriction |
3/49 |
64/18903 |
0.0006102 |
0.0024003 |
0.000852 |
PTGS2/RHOA/ACE |
3 |
| BP |
GO:0051893 |
regulation of focal adhesion assembly |
3/49 |
64/18903 |
0.0006102 |
0.0024003 |
0.000852 |
SRC/KDR/RHOA |
3 |
| BP |
GO:0090109 |
regulation of cell-substrate junction assembly |
3/49 |
64/18903 |
0.0006102 |
0.0024003 |
0.000852 |
SRC/KDR/RHOA |
3 |
| BP |
GO:0006940 |
regulation of smooth muscle contraction |
3/49 |
65/18903 |
0.0006386 |
0.0024988 |
0.000887 |
PTGS2/RHOA/KIT |
3 |
| BP |
GO:0032613 |
interleukin-10 production |
3/49 |
65/18903 |
0.0006386 |
0.0024988 |
0.000887 |
IL6/HGF/SYK |
3 |
| BP |
GO:0032653 |
regulation of interleukin-10 production |
3/49 |
65/18903 |
0.0006386 |
0.0024988 |
0.000887 |
IL6/HGF/SYK |
3 |
| BP |
GO:1905953 |
negative regulation of lipid localization |
3/49 |
65/18903 |
0.0006386 |
0.0024988 |
0.000887 |
TNF/IL6/AKT1 |
3 |
| BP |
GO:0030183 |
B cell differentiation |
4/49 |
152/18903 |
0.0006427 |
0.0025115 |
0.0008915 |
IL6/KIT/ITGB1/SYK |
4 |
| BP |
GO:1903706 |
regulation of hemopoiesis |
6/49 |
413/18903 |
0.0006628 |
0.0025867 |
0.0009182 |
TNF/STAT1/RHOA/MAPK14/SYK/CASP8 |
6 |
| BP |
GO:0034605 |
cellular response to heat |
3/49 |
66/18903 |
0.0006678 |
0.0025897 |
0.0009192 |
PTGS2/SIRT1/HMOX1 |
3 |
| BP |
GO:0007584 |
response to nutrient |
4/49 |
154/18903 |
0.0006749 |
0.0025897 |
0.0009192 |
PTGS2/STAT1/IGF1R/HMOX1 |
4 |
| BP |
GO:0034763 |
negative regulation of transmembrane transport |
4/49 |
154/18903 |
0.0006749 |
0.0025897 |
0.0009192 |
TNF/AKT1/MMP9/ACE |
4 |
| BP |
GO:0031348 |
negative regulation of defense response |
5/49 |
272/18903 |
0.0006759 |
0.0025897 |
0.0009192 |
SRC/IGF1/HGF/MAPK14/SYK |
5 |
| BP |
GO:0034116 |
positive regulation of heterotypic cell-cell adhesion |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
TNF/LCK |
2 |
| BP |
GO:0042976 |
activation of Janus kinase activity |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
JAK2/CCL5 |
2 |
| BP |
GO:0043518 |
negative regulation of DNA damage response, signal transduction by p53 class mediator |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
MDM2/SIRT1 |
2 |
| BP |
GO:0045725 |
positive regulation of glycogen biosynthetic process |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
AKT1/IGF1 |
2 |
| BP |
GO:0048308 |
organelle inheritance |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0048313 |
Golgi inheritance |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0061307 |
cardiac neural crest cell differentiation involved in heart development |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0061308 |
cardiac neural crest cell development involved in heart development |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
MAPK3/MAPK1 |
2 |
| BP |
GO:1902563 |
regulation of neutrophil activation |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
TNF/SYK |
2 |
| BP |
GO:1904251 |
regulation of bile acid metabolic process |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
KIT/SIRT1 |
2 |
| BP |
GO:2001279 |
regulation of unsaturated fatty acid biosynthetic process |
2/49 |
15/18903 |
0.0006764 |
0.0025897 |
0.0009192 |
PTGS2/SIRT1 |
2 |
| BP |
GO:0009620 |
response to fungus |
3/49 |
67/18903 |
0.0006978 |
0.0026576 |
0.0009433 |
GAPDH/MPO/SYK |
3 |
| BP |
GO:0015909 |
long-chain fatty acid transport |
3/49 |
67/18903 |
0.0006978 |
0.0026576 |
0.0009433 |
AKT1/SYK/ACE |
3 |
| BP |
GO:0045576 |
mast cell activation |
3/49 |
67/18903 |
0.0006978 |
0.0026576 |
0.0009433 |
KIT/SYK/HMOX1 |
3 |
| BP |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
3/49 |
67/18903 |
0.0006978 |
0.0026576 |
0.0009433 |
TNF/EGFR/RHOA |
3 |
| BP |
GO:0061448 |
connective tissue development |
5/49 |
274/18903 |
0.0006986 |
0.0026576 |
0.0009433 |
MAPK3/PIK3CA/HRAS/SIRT1/MAPK14 |
5 |
| BP |
GO:0030098 |
lymphocyte differentiation |
6/49 |
419/18903 |
0.0007146 |
0.0027153 |
0.0009638 |
IL6/RHOA/KIT/ITGB1/SYK/LCK |
6 |
| BP |
GO:0042987 |
amyloid precursor protein catabolic process |
3/49 |
68/18903 |
0.0007287 |
0.0027582 |
0.000979 |
TNF/CASP3/IGF1 |
3 |
| BP |
GO:0043550 |
regulation of lipid kinase activity |
3/49 |
68/18903 |
0.0007287 |
0.0027582 |
0.000979 |
SRC/KIT/FLT1 |
3 |
| BP |
GO:1902808 |
positive regulation of cell cycle G1/S phase transition |
3/49 |
68/18903 |
0.0007287 |
0.0027582 |
0.000979 |
AKT1/EGFR/MDM2 |
3 |
| BP |
GO:0016032 |
viral process |
6/49 |
421/18903 |
0.0007326 |
0.0027696 |
0.0009831 |
TNF/EGFR/STAT1/ITGB1/CCL5/CTSB |
6 |
| BP |
GO:0001678 |
cellular glucose homeostasis |
4/49 |
158/18903 |
0.0007429 |
0.0028016 |
0.0009944 |
PIK3CA/SIRT1/IGF1R/ACE |
4 |
| BP |
GO:0044409 |
entry into host |
4/49 |
158/18903 |
0.0007429 |
0.0028016 |
0.0009944 |
EGFR/SRC/ITGB1/CTSB |
4 |
| BP |
GO:0051962 |
positive regulation of nervous system development |
5/49 |
279/18903 |
0.0007578 |
0.0028497 |
0.0010115 |
TNF/IL6/KIT/ITGB1/ACE |
5 |
| BP |
GO:0007004 |
telomere maintenance via telomerase |
3/49 |
69/18903 |
0.0007604 |
0.0028497 |
0.0010115 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0048645 |
animal organ formation |
3/49 |
69/18903 |
0.0007604 |
0.0028497 |
0.0010115 |
MAPK3/MAPK1/AR |
3 |
| BP |
GO:0150116 |
regulation of cell-substrate junction organization |
3/49 |
69/18903 |
0.0007604 |
0.0028497 |
0.0010115 |
SRC/KDR/RHOA |
3 |
| BP |
GO:2000401 |
regulation of lymphocyte migration |
3/49 |
69/18903 |
0.0007604 |
0.0028497 |
0.0010115 |
AKT1/RHOA/CCL5 |
3 |
| BP |
GO:0044843 |
cell cycle G1/S phase transition |
5/49 |
280/18903 |
0.0007701 |
0.0028674 |
0.0010178 |
AKT1/EGFR/ITGB1/MDM2/CDK2 |
5 |
| BP |
GO:0046325 |
negative regulation of glucose import |
2/49 |
16/18903 |
0.0007718 |
0.0028674 |
0.0010178 |
TNF/ACE |
2 |
| BP |
GO:0070875 |
positive regulation of glycogen metabolic process |
2/49 |
16/18903 |
0.0007718 |
0.0028674 |
0.0010178 |
AKT1/IGF1 |
2 |
| BP |
GO:0071391 |
cellular response to estrogen stimulus |
2/49 |
16/18903 |
0.0007718 |
0.0028674 |
0.0010178 |
ESR1/AR |
2 |
| BP |
GO:0090030 |
regulation of steroid hormone biosynthetic process |
2/49 |
16/18903 |
0.0007718 |
0.0028674 |
0.0010178 |
IGF1R/NR3C1 |
2 |
| BP |
GO:0090336 |
positive regulation of brown fat cell differentiation |
2/49 |
16/18903 |
0.0007718 |
0.0028674 |
0.0010178 |
PTGS2/MAPK14 |
2 |
| BP |
GO:2000696 |
regulation of epithelial cell differentiation involved in kidney development |
2/49 |
16/18903 |
0.0007718 |
0.0028674 |
0.0010178 |
MMP9/STAT1 |
2 |
| BP |
GO:0014823 |
response to activity |
3/49 |
70/18903 |
0.000793 |
0.0029354 |
0.0010419 |
TNF/IL6/PIK3CA |
3 |
| BP |
GO:0043627 |
response to estrogen |
3/49 |
70/18903 |
0.000793 |
0.0029354 |
0.0010419 |
ESR1/HMOX1/AR |
3 |
| BP |
GO:0051881 |
regulation of mitochondrial membrane potential |
3/49 |
70/18903 |
0.000793 |
0.0029354 |
0.0010419 |
AKT1/SRC/KDR |
3 |
| BP |
GO:0070527 |
platelet aggregation |
3/49 |
71/18903 |
0.0008265 |
0.0030556 |
0.0010846 |
IL6/JAK2/SYK |
3 |
| BP |
GO:0045600 |
positive regulation of fat cell differentiation |
3/49 |
72/18903 |
0.0008609 |
0.0031777 |
0.0011279 |
AKT1/PTGS2/MAPK14 |
3 |
| BP |
GO:0010763 |
positive regulation of fibroblast migration |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
AKT1/ITGB1 |
2 |
| BP |
GO:0017014 |
protein nitrosylation |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
GAPDH/ACE |
2 |
| BP |
GO:0018119 |
peptidyl-cysteine S-nitrosylation |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
GAPDH/ACE |
2 |
| BP |
GO:0031649 |
heat generation |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
TNF/PTGS2 |
2 |
| BP |
GO:0033631 |
cell-cell adhesion mediated by integrin |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
ITGB1/CCL5 |
2 |
| BP |
GO:0038065 |
collagen-activated signaling pathway |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
JAK2/SYK |
2 |
| BP |
GO:0071732 |
cellular response to nitric oxide |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
MMP3/CDK2 |
2 |
| BP |
GO:0098712 |
L-glutamate import across plasma membrane |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
TNF/ITGB1 |
2 |
| BP |
GO:0110096 |
cellular response to aldehyde |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
IGF1R/ACE |
2 |
| BP |
GO:1903358 |
regulation of Golgi organization |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
MAPK3/MAPK1 |
2 |
| BP |
GO:1904355 |
positive regulation of telomere capping |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
MAPK3/MAPK1 |
2 |
| BP |
GO:2001267 |
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
2/49 |
17/18903 |
0.0008733 |
0.0031777 |
0.0011279 |
MMP9/JAK2 |
2 |
| BP |
GO:0030032 |
lamellipodium assembly |
3/49 |
73/18903 |
0.0008962 |
0.0032532 |
0.0011547 |
PIK3CA/KIT/ITGB1 |
3 |
| BP |
GO:0046635 |
positive regulation of alpha-beta T cell activation |
3/49 |
73/18903 |
0.0008962 |
0.0032532 |
0.0011547 |
RHOA/JAK2/SYK |
3 |
| BP |
GO:0046942 |
carboxylic acid transport |
5/49 |
290/18903 |
0.0009014 |
0.0032681 |
0.00116 |
TNF/PTGS2/ITGB1/SYK/ACE |
5 |
| BP |
GO:0030307 |
positive regulation of cell growth |
4/49 |
167/18903 |
0.0009135 |
0.003308 |
0.0011742 |
AKT1/EGFR/IGF1/RHOA |
4 |
| BP |
GO:0045936 |
negative regulation of phosphate metabolic process |
6/49 |
440/18903 |
0.0009214 |
0.0033328 |
0.001183 |
TNF/AKT1/CASP3/HGF/SIRT1/LGALS3 |
6 |
| BP |
GO:0010563 |
negative regulation of phosphorus metabolic process |
6/49 |
441/18903 |
0.0009323 |
0.0033482 |
0.0011884 |
TNF/AKT1/CASP3/HGF/SIRT1/LGALS3 |
6 |
| BP |
GO:0006801 |
superoxide metabolic process |
3/49 |
74/18903 |
0.0009323 |
0.0033482 |
0.0011884 |
MPO/SYK/NOS3 |
3 |
| BP |
GO:0045123 |
cellular extravasation |
3/49 |
74/18903 |
0.0009323 |
0.0033482 |
0.0011884 |
TNF/ITGB1/SELE |
3 |
| BP |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
3/49 |
74/18903 |
0.0009323 |
0.0033482 |
0.0011884 |
RHOA/HMOX1/NOS3 |
3 |
| BP |
GO:0051926 |
negative regulation of calcium ion transport |
3/49 |
74/18903 |
0.0009323 |
0.0033482 |
0.0011884 |
PTGS2/ACE/NOS3 |
3 |
| BP |
GO:2000628 |
regulation of miRNA metabolic process |
3/49 |
74/18903 |
0.0009323 |
0.0033482 |
0.0011884 |
TNF/HRAS/NR3C1 |
3 |
| BP |
GO:0002366 |
leukocyte activation involved in immune response |
5/49 |
293/18903 |
0.0009438 |
0.0033814 |
0.0012002 |
IL6/KIT/SYK/HMOX1/LGALS3 |
5 |
| BP |
GO:0051146 |
striated muscle cell differentiation |
5/49 |
293/18903 |
0.0009438 |
0.0033814 |
0.0012002 |
AKT1/CASP3/IGF1/ITGB1/MAPK14 |
5 |
| BP |
GO:0007568 |
aging |
4/49 |
169/18903 |
0.0009548 |
0.0034167 |
0.0012128 |
PTGS2/IGF1R/MPO/ACE |
4 |
| BP |
GO:0006278 |
RNA-templated DNA biosynthetic process |
3/49 |
75/18903 |
0.0009694 |
0.0034566 |
0.0012269 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0045669 |
positive regulation of osteoblast differentiation |
3/49 |
75/18903 |
0.0009694 |
0.0034566 |
0.0012269 |
IL6/IGF1/HGF |
3 |
| BP |
GO:0050818 |
regulation of coagulation |
3/49 |
75/18903 |
0.0009694 |
0.0034566 |
0.0012269 |
ANXA5/NOS3/PLAU |
3 |
| BP |
GO:0010958 |
regulation of amino acid import across plasma membrane |
2/49 |
18/18903 |
0.0009808 |
0.0034644 |
0.0012297 |
TNF/ITGB1 |
2 |
| BP |
GO:0038128 |
ERBB2 signaling pathway |
2/49 |
18/18903 |
0.0009808 |
0.0034644 |
0.0012297 |
EGFR/SRC |
2 |
| BP |
GO:0045780 |
positive regulation of bone resorption |
2/49 |
18/18903 |
0.0009808 |
0.0034644 |
0.0012297 |
SRC/SYK |
2 |
| BP |
GO:0048569 |
post-embryonic animal organ development |
2/49 |
18/18903 |
0.0009808 |
0.0034644 |
0.0012297 |
KDR/JAK2 |
2 |
| BP |
GO:0051900 |
regulation of mitochondrial depolarization |
2/49 |
18/18903 |
0.0009808 |
0.0034644 |
0.0012297 |
SRC/KDR |
2 |
| BP |
GO:0097067 |
cellular response to thyroid hormone stimulus |
2/49 |
18/18903 |
0.0009808 |
0.0034644 |
0.0012297 |
KIT/CTSB |
2 |
| BP |
GO:0150078 |
positive regulation of neuroinflammatory response |
2/49 |
18/18903 |
0.0009808 |
0.0034644 |
0.0012297 |
TNF/IL6 |
2 |
| BP |
GO:1903789 |
regulation of amino acid transmembrane transport |
2/49 |
18/18903 |
0.0009808 |
0.0034644 |
0.0012297 |
TNF/ITGB1 |
2 |
| BP |
GO:0030217 |
T cell differentiation |
5/49 |
296/18903 |
0.0009877 |
0.0034808 |
0.0012355 |
IL6/RHOA/KIT/SYK/LCK |
5 |
| BP |
GO:0044262 |
cellular carbohydrate metabolic process |
5/49 |
296/18903 |
0.0009877 |
0.0034808 |
0.0012355 |
AKT1/SRC/IGF1/SIRT1/NR3C1 |
5 |
| BP |
GO:0046661 |
male sex differentiation |
4/49 |
171/18903 |
0.0009974 |
0.0035109 |
0.0012462 |
ESR1/KIT/ACE/AR |
4 |
| BP |
GO:0002263 |
cell activation involved in immune response |
5/49 |
297/18903 |
0.0010027 |
0.0035253 |
0.0012513 |
IL6/KIT/SYK/HMOX1/LGALS3 |
5 |
| BP |
GO:0001937 |
negative regulation of endothelial cell proliferation |
3/49 |
76/18903 |
0.0010074 |
0.0035336 |
0.0012543 |
TNF/STAT1/FLT1 |
3 |
| BP |
GO:0010822 |
positive regulation of mitochondrion organization |
3/49 |
76/18903 |
0.0010074 |
0.0035336 |
0.0012543 |
MMP9/KDR/MAPK8 |
3 |
| BP |
GO:0072594 |
establishment of protein localization to organelle |
6/49 |
449/18903 |
0.001023 |
0.0035842 |
0.0012722 |
AKT1/PTGS2/JAK2/MAPK8/MAPK14/SYK |
6 |
| BP |
GO:0002534 |
cytokine production involved in inflammatory response |
3/49 |
77/18903 |
0.0010464 |
0.0036532 |
0.0012967 |
TNF/IL6/MAPK14 |
3 |
| BP |
GO:0032729 |
positive regulation of interferon-gamma production |
3/49 |
77/18903 |
0.0010464 |
0.0036532 |
0.0012967 |
TNF/HRAS/JAK2 |
3 |
| BP |
GO:1900015 |
regulation of cytokine production involved in inflammatory response |
3/49 |
77/18903 |
0.0010464 |
0.0036532 |
0.0012967 |
TNF/IL6/MAPK14 |
3 |
| BP |
GO:0021543 |
pallium development |
4/49 |
174/18903 |
0.0010639 |
0.0037058 |
0.0013154 |
EGFR/CASP3/RHOA/IGF1R |
4 |
| BP |
GO:0046631 |
alpha-beta T cell activation |
4/49 |
174/18903 |
0.0010639 |
0.0037058 |
0.0013154 |
IL6/RHOA/JAK2/SYK |
4 |
| BP |
GO:0061045 |
negative regulation of wound healing |
3/49 |
78/18903 |
0.0010862 |
0.0037727 |
0.0013391 |
TNF/NOS3/PLAU |
3 |
| BP |
GO:0002523 |
leukocyte migration involved in inflammatory response |
2/49 |
19/18903 |
0.0010944 |
0.0037727 |
0.0013391 |
TNF/SELE |
2 |
| BP |
GO:0002544 |
chronic inflammatory response |
2/49 |
19/18903 |
0.0010944 |
0.0037727 |
0.0013391 |
TNF/CCL5 |
2 |
| BP |
GO:0045346 |
regulation of MHC class II biosynthetic process |
2/49 |
19/18903 |
0.0010944 |
0.0037727 |
0.0013391 |
JAK2/SIRT1 |
2 |
| BP |
GO:0048245 |
eosinophil chemotaxis |
2/49 |
19/18903 |
0.0010944 |
0.0037727 |
0.0013391 |
CCL5/LGALS3 |
2 |
| BP |
GO:0051152 |
positive regulation of smooth muscle cell differentiation |
2/49 |
19/18903 |
0.0010944 |
0.0037727 |
0.0013391 |
KIT/SIRT1 |
2 |
| BP |
GO:0060438 |
trachea development |
2/49 |
19/18903 |
0.0010944 |
0.0037727 |
0.0013391 |
MAPK3/MAPK1 |
2 |
| BP |
GO:1902170 |
cellular response to reactive nitrogen species |
2/49 |
19/18903 |
0.0010944 |
0.0037727 |
0.0013391 |
MMP3/CDK2 |
2 |
| BP |
GO:1902176 |
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
2/49 |
19/18903 |
0.0010944 |
0.0037727 |
0.0013391 |
AKT1/SIRT1 |
2 |
| BP |
GO:0032635 |
interleukin-6 production |
4/49 |
176/18903 |
0.0011099 |
0.0038131 |
0.0013535 |
TNF/IL6/HGF/SYK |
4 |
| BP |
GO:0032675 |
regulation of interleukin-6 production |
4/49 |
176/18903 |
0.0011099 |
0.0038131 |
0.0013535 |
TNF/IL6/HGF/SYK |
4 |
| BP |
GO:0050680 |
negative regulation of epithelial cell proliferation |
4/49 |
176/18903 |
0.0011099 |
0.0038131 |
0.0013535 |
TNF/STAT1/FLT1/AR |
4 |
| BP |
GO:0043299 |
leukocyte degranulation |
3/49 |
79/18903 |
0.0011271 |
0.0038677 |
0.0013729 |
KIT/SYK/HMOX1 |
3 |
| BP |
GO:0051099 |
positive regulation of binding |
4/49 |
177/18903 |
0.0011334 |
0.003885 |
0.001379 |
MMP9/IGF1/JAK2/ACE |
4 |
| BP |
GO:0006694 |
steroid biosynthetic process |
4/49 |
178/18903 |
0.0011573 |
0.0039623 |
0.0014064 |
TNF/SIRT1/IGF1R/NR3C1 |
4 |
| BP |
GO:0010720 |
positive regulation of cell development |
5/49 |
307/18903 |
0.0011619 |
0.0039737 |
0.0014105 |
TNF/IL6/KIT/ITGB1/ACE |
5 |
| BP |
GO:0070227 |
lymphocyte apoptotic process |
3/49 |
80/18903 |
0.0011689 |
0.0039929 |
0.0014173 |
AKT1/CCL5/LGALS3 |
3 |
| BP |
GO:0090276 |
regulation of peptide hormone secretion |
4/49 |
179/18903 |
0.0011815 |
0.0040315 |
0.001431 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0002443 |
leukocyte mediated immunity |
6/49 |
463/18903 |
0.001198 |
0.0040833 |
0.0014494 |
TNF/IL6/KIT/SYK/HMOX1/ACE |
6 |
| BP |
GO:0010833 |
telomere maintenance via telomere lengthening |
3/49 |
81/18903 |
0.0012116 |
0.0041005 |
0.0014555 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0045342 |
MHC class II biosynthetic process |
2/49 |
20/18903 |
0.001214 |
0.0041005 |
0.0014555 |
JAK2/SIRT1 |
2 |
| BP |
GO:0051882 |
mitochondrial depolarization |
2/49 |
20/18903 |
0.001214 |
0.0041005 |
0.0014555 |
SRC/KDR |
2 |
| BP |
GO:0060716 |
labyrinthine layer blood vessel development |
2/49 |
20/18903 |
0.001214 |
0.0041005 |
0.0014555 |
AKT1/MAPK1 |
2 |
| BP |
GO:0060749 |
mammary gland alveolus development |
2/49 |
20/18903 |
0.001214 |
0.0041005 |
0.0014555 |
ESR1/AR |
2 |
| BP |
GO:0061377 |
mammary gland lobule development |
2/49 |
20/18903 |
0.001214 |
0.0041005 |
0.0014555 |
ESR1/AR |
2 |
| BP |
GO:1902004 |
positive regulation of amyloid-beta formation |
2/49 |
20/18903 |
0.001214 |
0.0041005 |
0.0014555 |
TNF/CASP3 |
2 |
| BP |
GO:2000010 |
positive regulation of protein localization to cell surface |
2/49 |
20/18903 |
0.001214 |
0.0041005 |
0.0014555 |
TNF/AKT1 |
2 |
| BP |
GO:0042770 |
signal transduction in response to DNA damage |
4/49 |
181/18903 |
0.001231 |
0.0041533 |
0.0014742 |
MDM2/SIRT1/MAPK14/CDK2 |
4 |
| BP |
GO:1902117 |
positive regulation of organelle assembly |
3/49 |
82/18903 |
0.0012553 |
0.0042291 |
0.0015011 |
TNF/SRC/RHOA |
3 |
| BP |
GO:0002791 |
regulation of peptide secretion |
4/49 |
182/18903 |
0.0012563 |
0.0042291 |
0.0015011 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0007219 |
Notch signaling pathway |
4/49 |
183/18903 |
0.0012819 |
0.0043011 |
0.0015267 |
AKT1/SRC/KIT/NOS3 |
4 |
| BP |
GO:0030073 |
insulin secretion |
4/49 |
183/18903 |
0.0012819 |
0.0043011 |
0.0015267 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0044000 |
movement in host |
4/49 |
183/18903 |
0.0012819 |
0.0043011 |
0.0015267 |
EGFR/SRC/ITGB1/CTSB |
4 |
| BP |
GO:0006909 |
phagocytosis |
5/49 |
314/18903 |
0.001284 |
0.0043033 |
0.0015275 |
TNF/SRC/PIK3CA/ITGB1/SYK |
5 |
| BP |
GO:0023061 |
signal release |
6/49 |
470/18903 |
0.0012937 |
0.0043311 |
0.0015373 |
TNF/IL6/PTGS2/JAK2/CCL5/SYK |
6 |
| BP |
GO:0031507 |
heterochromatin formation |
3/49 |
83/18903 |
0.0013001 |
0.0043379 |
0.0015397 |
PIK3CA/SIRT1/CDK2 |
3 |
| BP |
GO:0042310 |
vasoconstriction |
3/49 |
83/18903 |
0.0013001 |
0.0043379 |
0.0015397 |
PTGS2/RHOA/ACE |
3 |
| BP |
GO:0050848 |
regulation of calcium-mediated signaling |
3/49 |
83/18903 |
0.0013001 |
0.0043379 |
0.0015397 |
TNF/IGF1/SYK |
3 |
| BP |
GO:0032640 |
tumor necrosis factor production |
4/49 |
184/18903 |
0.0013079 |
0.00434 |
0.0015405 |
IL6/IGF1/JAK2/SYK |
4 |
| BP |
GO:0032680 |
regulation of tumor necrosis factor production |
4/49 |
184/18903 |
0.0013079 |
0.00434 |
0.0015405 |
IL6/IGF1/JAK2/SYK |
4 |
| BP |
GO:0090087 |
regulation of peptide transport |
4/49 |
184/18903 |
0.0013079 |
0.00434 |
0.0015405 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:1902107 |
positive regulation of leukocyte differentiation |
4/49 |
184/18903 |
0.0013079 |
0.00434 |
0.0015405 |
TNF/RHOA/SYK/CASP8 |
4 |
| BP |
GO:1903708 |
positive regulation of hemopoiesis |
4/49 |
184/18903 |
0.0013079 |
0.00434 |
0.0015405 |
TNF/RHOA/SYK/CASP8 |
4 |
| BP |
GO:2000045 |
regulation of G1/S transition of mitotic cell cycle |
4/49 |
185/18903 |
0.0013343 |
0.0044013 |
0.0015622 |
AKT1/EGFR/MDM2/CDK2 |
4 |
| BP |
GO:1903131 |
mononuclear cell differentiation |
6/49 |
473/18903 |
0.0013365 |
0.0044013 |
0.0015622 |
IL6/RHOA/KIT/ITGB1/SYK/LCK |
6 |
| BP |
GO:0007252 |
I-kappaB phosphorylation |
2/49 |
21/18903 |
0.0013395 |
0.0044013 |
0.0015622 |
TNF/AKT1 |
2 |
| BP |
GO:0010829 |
negative regulation of glucose transmembrane transport |
2/49 |
21/18903 |
0.0013395 |
0.0044013 |
0.0015622 |
TNF/ACE |
2 |
| BP |
GO:0045056 |
transcytosis |
2/49 |
21/18903 |
0.0013395 |
0.0044013 |
0.0015622 |
SRC/IGF1R |
2 |
| BP |
GO:0060252 |
positive regulation of glial cell proliferation |
2/49 |
21/18903 |
0.0013395 |
0.0044013 |
0.0015622 |
TNF/IL6 |
2 |
| BP |
GO:0060445 |
branching involved in salivary gland morphogenesis |
2/49 |
21/18903 |
0.0013395 |
0.0044013 |
0.0015622 |
TNF/HGF |
2 |
| BP |
GO:0071498 |
cellular response to fluid shear stress |
2/49 |
21/18903 |
0.0013395 |
0.0044013 |
0.0015622 |
SRC/PTGS2 |
2 |
| BP |
GO:0071731 |
response to nitric oxide |
2/49 |
21/18903 |
0.0013395 |
0.0044013 |
0.0015622 |
MMP3/CDK2 |
2 |
| BP |
GO:0010921 |
regulation of phosphatase activity |
3/49 |
84/18903 |
0.0013458 |
0.0044074 |
0.0015644 |
TNF/JAK2/LGALS3 |
3 |
| BP |
GO:0032418 |
lysosome localization |
3/49 |
84/18903 |
0.0013458 |
0.0044074 |
0.0015644 |
KIT/SYK/HMOX1 |
3 |
| BP |
GO:1990849 |
vacuolar localization |
3/49 |
84/18903 |
0.0013458 |
0.0044074 |
0.0015644 |
KIT/SYK/HMOX1 |
3 |
| BP |
GO:0019058 |
viral life cycle |
5/49 |
319/18903 |
0.0013769 |
0.0045043 |
0.0015988 |
TNF/EGFR/ITGB1/CCL5/CTSB |
5 |
| BP |
GO:0034103 |
regulation of tissue remodeling |
3/49 |
85/18903 |
0.0013925 |
0.0045455 |
0.0016134 |
IL6/SRC/SYK |
3 |
| BP |
GO:0048041 |
focal adhesion assembly |
3/49 |
85/18903 |
0.0013925 |
0.0045455 |
0.0016134 |
SRC/KDR/RHOA |
3 |
| BP |
GO:0071706 |
tumor necrosis factor superfamily cytokine production |
4/49 |
189/18903 |
0.0014435 |
0.0047001 |
0.0016683 |
IL6/IGF1/JAK2/SYK |
4 |
| BP |
GO:1903555 |
regulation of tumor necrosis factor superfamily cytokine production |
4/49 |
189/18903 |
0.0014435 |
0.0047001 |
0.0016683 |
IL6/IGF1/JAK2/SYK |
4 |
| BP |
GO:0002070 |
epithelial cell maturation |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
KDR/PGR |
2 |
| BP |
GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
SRC/SYK |
2 |
| BP |
GO:0010888 |
negative regulation of lipid storage |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
TNF/IL6 |
2 |
| BP |
GO:0032069 |
regulation of nuclease activity |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
AKT1/SIRT1 |
2 |
| BP |
GO:0032891 |
negative regulation of organic acid transport |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
TNF/AKT1 |
2 |
| BP |
GO:0033630 |
positive regulation of cell adhesion mediated by integrin |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
CCL5/SYK |
2 |
| BP |
GO:0046628 |
positive regulation of insulin receptor signaling pathway |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
SRC/SIRT1 |
2 |
| BP |
GO:0051000 |
positive regulation of nitric-oxide synthase activity |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
TNF/AKT1 |
2 |
| BP |
GO:0060065 |
uterus development |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
SRC/ESR1 |
2 |
| BP |
GO:0061042 |
vascular wound healing |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
TNF/KDR |
2 |
| BP |
GO:0070886 |
positive regulation of calcineurin-NFAT signaling cascade |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
TNF/IGF1 |
2 |
| BP |
GO:0071404 |
cellular response to low-density lipoprotein particle stimulus |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
ITGB1/SYK |
2 |
| BP |
GO:0072574 |
hepatocyte proliferation |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
TNF/IL6 |
2 |
| BP |
GO:0072575 |
epithelial cell proliferation involved in liver morphogenesis |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
TNF/IL6 |
2 |
| BP |
GO:0106058 |
positive regulation of calcineurin-mediated signaling |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
TNF/IGF1 |
2 |
| BP |
GO:1903209 |
positive regulation of oxidative stress-induced cell death |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
TNF/MMP3 |
2 |
| BP |
GO:1990840 |
response to lectin |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
SRC/SYK |
2 |
| BP |
GO:1990858 |
cellular response to lectin |
2/49 |
22/18903 |
0.001471 |
0.0047001 |
0.0016683 |
SRC/SYK |
2 |
| BP |
GO:0015849 |
organic acid transport |
5/49 |
324/18903 |
0.0014746 |
0.0047066 |
0.0016706 |
TNF/AKT1/ITGB1/SYK/ACE |
5 |
| BP |
GO:0019915 |
lipid storage |
3/49 |
87/18903 |
0.0014889 |
0.0047472 |
0.001685 |
TNF/IL6/SIRT1 |
3 |
| BP |
GO:0006417 |
regulation of translation |
6/49 |
486/18903 |
0.0015345 |
0.0048873 |
0.0017348 |
TNF/IL6/GAPDH/AKT1/RHOA/CCL5 |
6 |
| BP |
GO:0006913 |
nucleocytoplasmic transport |
5/49 |
329/18903 |
0.0015774 |
0.0050134 |
0.0017795 |
AKT1/PTGS2/JAK2/MAPK14/SYK |
5 |
| BP |
GO:0051169 |
nuclear transport |
5/49 |
329/18903 |
0.0015774 |
0.0050134 |
0.0017795 |
AKT1/PTGS2/JAK2/MAPK14/SYK |
5 |
| BP |
GO:0046849 |
bone remodeling |
3/49 |
89/18903 |
0.0015895 |
0.0050411 |
0.0017894 |
IL6/SRC/SYK |
3 |
| BP |
GO:0071229 |
cellular response to acid chemical |
3/49 |
89/18903 |
0.0015895 |
0.0050411 |
0.0017894 |
TNF/EGFR/PIK3CA |
3 |
| BP |
GO:0002053 |
positive regulation of mesenchymal cell proliferation |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
KDR/STAT1 |
2 |
| BP |
GO:0002082 |
regulation of oxidative phosphorylation |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
TNF/RHOA |
2 |
| BP |
GO:0002363 |
alpha-beta T cell lineage commitment |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
IL6/RHOA |
2 |
| BP |
GO:0010893 |
positive regulation of steroid biosynthetic process |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
TNF/IGF1R |
2 |
| BP |
GO:0019430 |
removal of superoxide radicals |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
MPO/NOS3 |
2 |
| BP |
GO:0048143 |
astrocyte activation |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
TNF/IL6 |
2 |
| BP |
GO:0048169 |
regulation of long-term neuronal synaptic plasticity |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
KIT/HRAS |
2 |
| BP |
GO:0072576 |
liver morphogenesis |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
TNF/IL6 |
2 |
| BP |
GO:0072677 |
eosinophil migration |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
CCL5/LGALS3 |
2 |
| BP |
GO:1902254 |
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
2/49 |
23/18903 |
0.0016085 |
0.0050483 |
0.0017919 |
MDM2/SIRT1 |
2 |
| BP |
GO:0010586 |
miRNA metabolic process |
3/49 |
90/18903 |
0.0016413 |
0.0051414 |
0.001825 |
TNF/HRAS/NR3C1 |
3 |
| BP |
GO:0048638 |
regulation of developmental growth |
5/49 |
332/18903 |
0.0016416 |
0.0051414 |
0.001825 |
AKT1/IGF1/PIK3CA/MAPK14/AR |
5 |
| BP |
GO:0016049 |
cell growth |
6/49 |
493/18903 |
0.00165 |
0.0051625 |
0.0018324 |
AKT1/EGFR/IGF1/RHOA/ITGB1/SIRT1 |
6 |
| BP |
GO:0015980 |
energy derivation by oxidation of organic compounds |
5/49 |
333/18903 |
0.0016634 |
0.0051989 |
0.0018454 |
TNF/AKT1/IGF1/RHOA/PIK3CA |
5 |
| BP |
GO:0048525 |
negative regulation of viral process |
3/49 |
91/18903 |
0.0016942 |
0.0052842 |
0.0018756 |
TNF/STAT1/CCL5 |
3 |
| BP |
GO:0070828 |
heterochromatin organization |
3/49 |
91/18903 |
0.0016942 |
0.0052842 |
0.0018756 |
PIK3CA/SIRT1/CDK2 |
3 |
| BP |
GO:0002819 |
regulation of adaptive immune response |
4/49 |
198/18903 |
0.0017119 |
0.0053339 |
0.0018933 |
TNF/IL6/JAK2/SIRT1 |
4 |
| BP |
GO:0006925 |
inflammatory cell apoptotic process |
2/49 |
24/18903 |
0.0017518 |
0.0054246 |
0.0019255 |
IL6/SIRT1 |
2 |
| BP |
GO:0035162 |
embryonic hemopoiesis |
2/49 |
24/18903 |
0.0017518 |
0.0054246 |
0.0019255 |
KDR/KIT |
2 |
| BP |
GO:0038095 |
Fc-epsilon receptor signaling pathway |
2/49 |
24/18903 |
0.0017518 |
0.0054246 |
0.0019255 |
MAPK8/SYK |
2 |
| BP |
GO:0048011 |
neurotrophin TRK receptor signaling pathway |
2/49 |
24/18903 |
0.0017518 |
0.0054246 |
0.0019255 |
SRC/CASP3 |
2 |
| BP |
GO:0060571 |
morphogenesis of an epithelial fold |
2/49 |
24/18903 |
0.0017518 |
0.0054246 |
0.0019255 |
EGFR/AR |
2 |
| BP |
GO:2000637 |
positive regulation of miRNA-mediated gene silencing |
2/49 |
24/18903 |
0.0017518 |
0.0054246 |
0.0019255 |
IL6/EGFR |
2 |
| BP |
GO:0044070 |
regulation of anion transport |
3/49 |
93/18903 |
0.0018031 |
0.0055606 |
0.0019738 |
TNF/ITGB1/SYK |
3 |
| BP |
GO:0045814 |
negative regulation of gene expression, epigenetic |
3/49 |
93/18903 |
0.0018031 |
0.0055606 |
0.0019738 |
PIK3CA/SIRT1/CDK2 |
3 |
| BP |
GO:0050886 |
endocrine process |
3/49 |
93/18903 |
0.0018031 |
0.0055606 |
0.0019738 |
RHOA/ACE/NOS3 |
3 |
| BP |
GO:2000106 |
regulation of leukocyte apoptotic process |
3/49 |
93/18903 |
0.0018031 |
0.0055606 |
0.0019738 |
CCL5/SIRT1/LGALS3 |
3 |
| BP |
GO:0060491 |
regulation of cell projection assembly |
4/49 |
201/18903 |
0.0018085 |
0.0055717 |
0.0019777 |
SRC/PIK3CA/KIT/HRAS |
4 |
| BP |
GO:0022408 |
negative regulation of cell-cell adhesion |
4/49 |
202/18903 |
0.0018416 |
0.0056678 |
0.0020118 |
AKT1/CASP3/JAK2/LGALS3 |
4 |
| BP |
GO:0035304 |
regulation of protein dephosphorylation |
3/49 |
94/18903 |
0.0018592 |
0.0057102 |
0.0020268 |
TNF/JAK2/LGALS3 |
3 |
| BP |
GO:1903035 |
negative regulation of response to wounding |
3/49 |
94/18903 |
0.0018592 |
0.0057102 |
0.0020268 |
TNF/NOS3/PLAU |
3 |
| BP |
GO:0051235 |
maintenance of location |
5/49 |
342/18903 |
0.0018694 |
0.0057356 |
0.0020359 |
TNF/IL6/AKT1/SIRT1/LCK |
5 |
| BP |
GO:0051701 |
biological process involved in interaction with host |
4/49 |
203/18903 |
0.0018751 |
0.0057391 |
0.0020371 |
EGFR/SRC/ITGB1/CTSB |
4 |
| BP |
GO:0003081 |
regulation of systemic arterial blood pressure by renin-angiotensin |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
RHOA/ACE |
2 |
| BP |
GO:0034114 |
regulation of heterotypic cell-cell adhesion |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
TNF/LCK |
2 |
| BP |
GO:0035330 |
regulation of hippo signaling |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
SRC/MAPK14 |
2 |
| BP |
GO:0043567 |
regulation of insulin-like growth factor receptor signaling pathway |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
IGF1/AR |
2 |
| BP |
GO:0046641 |
positive regulation of alpha-beta T cell proliferation |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
JAK2/SYK |
2 |
| BP |
GO:0046697 |
decidualization |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
PTGS2/CTSB |
2 |
| BP |
GO:0046885 |
regulation of hormone biosynthetic process |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
IGF1R/NR3C1 |
2 |
| BP |
GO:0060148 |
positive regulation of post-transcriptional gene silencing |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
IL6/EGFR |
2 |
| BP |
GO:0060396 |
growth hormone receptor signaling pathway |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
JAK2/JAK1 |
2 |
| BP |
GO:0071378 |
cellular response to growth hormone stimulus |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
JAK2/JAK1 |
2 |
| BP |
GO:0071450 |
cellular response to oxygen radical |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
MPO/NOS3 |
2 |
| BP |
GO:0071451 |
cellular response to superoxide |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
MPO/NOS3 |
2 |
| BP |
GO:1900078 |
positive regulation of cellular response to insulin stimulus |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
SRC/SIRT1 |
2 |
| BP |
GO:1900370 |
positive regulation of post-transcriptional gene silencing by RNA |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
IL6/EGFR |
2 |
| BP |
GO:1902993 |
positive regulation of amyloid precursor protein catabolic process |
2/49 |
25/18903 |
0.001901 |
0.0057391 |
0.0020371 |
TNF/CASP3 |
2 |
| BP |
GO:0007044 |
cell-substrate junction assembly |
3/49 |
95/18903 |
0.0019163 |
0.0057739 |
0.0020494 |
SRC/KDR/RHOA |
3 |
| BP |
GO:0042982 |
amyloid precursor protein metabolic process |
3/49 |
95/18903 |
0.0019163 |
0.0057739 |
0.0020494 |
TNF/CASP3/IGF1 |
3 |
| BP |
GO:0002275 |
myeloid cell activation involved in immune response |
3/49 |
96/18903 |
0.0019745 |
0.0059374 |
0.0021075 |
KIT/SYK/HMOX1 |
3 |
| BP |
GO:0019217 |
regulation of fatty acid metabolic process |
3/49 |
96/18903 |
0.0019745 |
0.0059374 |
0.0021075 |
AKT1/PTGS2/SIRT1 |
3 |
| BP |
GO:0007517 |
muscle organ development |
5/49 |
348/18903 |
0.0020167 |
0.0060582 |
0.0021504 |
IGF1/RHOA/ITGB1/SIRT1/MAPK14 |
5 |
| BP |
GO:0045216 |
cell-cell junction organization |
4/49 |
208/18903 |
0.0020488 |
0.0061032 |
0.0021663 |
TNF/SRC/RHOA/ACE |
4 |
| BP |
GO:0002433 |
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
SRC/SYK |
2 |
| BP |
GO:0032515 |
negative regulation of phosphoprotein phosphatase activity |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
TNF/LGALS3 |
2 |
| BP |
GO:0033598 |
mammary gland epithelial cell proliferation |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
ESR1/MAPK1 |
2 |
| BP |
GO:0035994 |
response to muscle stretch |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
PIK3CA/MAPK14 |
2 |
| BP |
GO:0038096 |
Fc-gamma receptor signaling pathway involved in phagocytosis |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
SRC/SYK |
2 |
| BP |
GO:0043931 |
ossification involved in bone maturation |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
IGF1/RHOA |
2 |
| BP |
GO:0044346 |
fibroblast apoptotic process |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
CASP3/PIK3CA |
2 |
| BP |
GO:0045822 |
negative regulation of heart contraction |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
TNF/JAK2 |
2 |
| BP |
GO:0050995 |
negative regulation of lipid catabolic process |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
TNF/AKT1 |
2 |
| BP |
GO:0060740 |
prostate gland epithelium morphogenesis |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
ESR1/AR |
2 |
| BP |
GO:1904353 |
regulation of telomere capping |
2/49 |
26/18903 |
0.002056 |
0.0061032 |
0.0021663 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0030100 |
regulation of endocytosis |
4/49 |
209/18903 |
0.0020848 |
0.0061825 |
0.0021945 |
SRC/SYK/SELE/LGALS3 |
4 |
| BP |
GO:0006936 |
muscle contraction |
5/49 |
351/18903 |
0.0020935 |
0.0061986 |
0.0022002 |
TNF/PTGS2/RHOA/PIK3CA/KIT |
5 |
| BP |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
3/49 |
98/18903 |
0.0020943 |
0.0061986 |
0.0022002 |
JAK2/IGF1R/SYK |
3 |
| BP |
GO:0032755 |
positive regulation of interleukin-6 production |
3/49 |
99/18903 |
0.0021558 |
0.0063744 |
0.0022626 |
TNF/IL6/SYK |
3 |
| BP |
GO:0016051 |
carbohydrate biosynthetic process |
4/49 |
212/18903 |
0.0021955 |
0.0064854 |
0.002302 |
AKT1/IGF1/SIRT1/NR3C1 |
4 |
| BP |
GO:0002092 |
positive regulation of receptor internalization |
2/49 |
27/18903 |
0.0022168 |
0.0064896 |
0.0023035 |
SYK/SELE |
2 |
| BP |
GO:0031954 |
positive regulation of protein autophosphorylation |
2/49 |
27/18903 |
0.0022168 |
0.0064896 |
0.0023035 |
SRC/ACE |
2 |
| BP |
GO:0032740 |
positive regulation of interleukin-17 production |
2/49 |
27/18903 |
0.0022168 |
0.0064896 |
0.0023035 |
IL6/JAK2 |
2 |
| BP |
GO:0070269 |
pyroptosis |
2/49 |
27/18903 |
0.0022168 |
0.0064896 |
0.0023035 |
CASP1/CASP8 |
2 |
| BP |
GO:1903523 |
negative regulation of blood circulation |
2/49 |
27/18903 |
0.0022168 |
0.0064896 |
0.0023035 |
TNF/JAK2 |
2 |
| BP |
GO:0001776 |
leukocyte homeostasis |
3/49 |
100/18903 |
0.0022185 |
0.0064896 |
0.0023035 |
IL6/AKT1/CASP3 |
3 |
| BP |
GO:0030316 |
osteoclast differentiation |
3/49 |
100/18903 |
0.0022185 |
0.0064896 |
0.0023035 |
TNF/SRC/MAPK14 |
3 |
| BP |
GO:0097306 |
cellular response to alcohol |
3/49 |
100/18903 |
0.0022185 |
0.0064896 |
0.0023035 |
AKT1/IGF1R/ACE |
3 |
| BP |
GO:0098869 |
cellular oxidant detoxification |
3/49 |
100/18903 |
0.0022185 |
0.0064896 |
0.0023035 |
PTGS2/MPO/NOS3 |
3 |
| BP |
GO:1901992 |
positive regulation of mitotic cell cycle phase transition |
3/49 |
100/18903 |
0.0022185 |
0.0064896 |
0.0023035 |
AKT1/EGFR/MDM2 |
3 |
| BP |
GO:1902806 |
regulation of cell cycle G1/S phase transition |
4/49 |
213/18903 |
0.0022333 |
0.0065266 |
0.0023166 |
AKT1/EGFR/MDM2/CDK2 |
4 |
| BP |
GO:0008016 |
regulation of heart contraction |
4/49 |
214/18903 |
0.0022715 |
0.0066255 |
0.0023517 |
TNF/JAK2/MDM2/NOS3 |
4 |
| BP |
GO:0045637 |
regulation of myeloid cell differentiation |
4/49 |
214/18903 |
0.0022715 |
0.0066255 |
0.0023517 |
TNF/STAT1/MAPK14/CASP8 |
4 |
| BP |
GO:0015908 |
fatty acid transport |
3/49 |
101/18903 |
0.0022823 |
0.0066375 |
0.002356 |
AKT1/SYK/ACE |
3 |
| BP |
GO:0032204 |
regulation of telomere maintenance |
3/49 |
101/18903 |
0.0022823 |
0.0066375 |
0.002356 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0150115 |
cell-substrate junction organization |
3/49 |
101/18903 |
0.0022823 |
0.0066375 |
0.002356 |
SRC/KDR/RHOA |
3 |
| BP |
GO:0009306 |
protein secretion |
5/49 |
359/18903 |
0.0023088 |
0.0067081 |
0.0023811 |
TNF/IL6/IGF1/JAK2/CCL5 |
5 |
| BP |
GO:0035592 |
establishment of protein localization to extracellular region |
5/49 |
360/18903 |
0.0023368 |
0.0067829 |
0.0024076 |
TNF/IL6/IGF1/JAK2/CCL5 |
5 |
| BP |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
3/49 |
102/18903 |
0.0023472 |
0.0068065 |
0.002416 |
TNF/SIRT1/HMOX1 |
3 |
| BP |
GO:0042176 |
regulation of protein catabolic process |
5/49 |
361/18903 |
0.002365 |
0.0068517 |
0.002432 |
TNF/AKT1/EGFR/MDM2/CDK2 |
5 |
| BP |
GO:0000303 |
response to superoxide |
2/49 |
28/18903 |
0.0023834 |
0.0068523 |
0.0024322 |
MPO/NOS3 |
2 |
| BP |
GO:0030878 |
thyroid gland development |
2/49 |
28/18903 |
0.0023834 |
0.0068523 |
0.0024322 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0031445 |
regulation of heterochromatin formation |
2/49 |
28/18903 |
0.0023834 |
0.0068523 |
0.0024322 |
PIK3CA/CDK2 |
2 |
| BP |
GO:0060512 |
prostate gland morphogenesis |
2/49 |
28/18903 |
0.0023834 |
0.0068523 |
0.0024322 |
ESR1/AR |
2 |
| BP |
GO:0120261 |
regulation of heterochromatin organization |
2/49 |
28/18903 |
0.0023834 |
0.0068523 |
0.0024322 |
PIK3CA/CDK2 |
2 |
| BP |
GO:1900017 |
positive regulation of cytokine production involved in inflammatory response |
2/49 |
28/18903 |
0.0023834 |
0.0068523 |
0.0024322 |
TNF/IL6 |
2 |
| BP |
GO:1903959 |
regulation of anion transmembrane transport |
2/49 |
28/18903 |
0.0023834 |
0.0068523 |
0.0024322 |
TNF/ITGB1 |
2 |
| BP |
GO:1904385 |
cellular response to angiotensin |
2/49 |
28/18903 |
0.0023834 |
0.0068523 |
0.0024322 |
SRC/IGF1R |
2 |
| BP |
GO:0032677 |
regulation of interleukin-8 production |
3/49 |
103/18903 |
0.0024132 |
0.0069247 |
0.002458 |
TNF/IL6/SYK |
3 |
| BP |
GO:0046620 |
regulation of organ growth |
3/49 |
103/18903 |
0.0024132 |
0.0069247 |
0.002458 |
AKT1/IGF1/MAPK14 |
3 |
| BP |
GO:0032637 |
interleukin-8 production |
3/49 |
104/18903 |
0.0024804 |
0.0071107 |
0.002524 |
TNF/IL6/SYK |
3 |
| BP |
GO:0010639 |
negative regulation of organelle organization |
5/49 |
366/18903 |
0.00251 |
0.0071888 |
0.0025517 |
AKT1/SRC/IGF1/PIK3CA/HGF |
5 |
| BP |
GO:0032479 |
regulation of type I interferon production |
3/49 |
105/18903 |
0.0025487 |
0.0072304 |
0.0025665 |
GAPDH/STAT1/SYK |
3 |
| BP |
GO:0032606 |
type I interferon production |
3/49 |
105/18903 |
0.0025487 |
0.0072304 |
0.0025665 |
GAPDH/STAT1/SYK |
3 |
| BP |
GO:0032760 |
positive regulation of tumor necrosis factor production |
3/49 |
105/18903 |
0.0025487 |
0.0072304 |
0.0025665 |
IL6/JAK2/SYK |
3 |
| BP |
GO:1901796 |
regulation of signal transduction by p53 class mediator |
3/49 |
105/18903 |
0.0025487 |
0.0072304 |
0.0025665 |
AKT1/MDM2/SIRT1 |
3 |
| BP |
GO:0050866 |
negative regulation of cell activation |
4/49 |
221/18903 |
0.002552 |
0.0072304 |
0.0025665 |
CASP3/HMOX1/NOS3/LGALS3 |
4 |
| BP |
GO:0000305 |
response to oxygen radical |
2/49 |
29/18903 |
0.0025557 |
0.0072304 |
0.0025665 |
MPO/NOS3 |
2 |
| BP |
GO:0007263 |
nitric oxide mediated signal transduction |
2/49 |
29/18903 |
0.0025557 |
0.0072304 |
0.0025665 |
EGFR/NOS3 |
2 |
| BP |
GO:0010575 |
positive regulation of vascular endothelial growth factor production |
2/49 |
29/18903 |
0.0025557 |
0.0072304 |
0.0025665 |
IL6/PTGS2 |
2 |
| BP |
GO:0015813 |
L-glutamate transmembrane transport |
2/49 |
29/18903 |
0.0025557 |
0.0072304 |
0.0025665 |
TNF/ITGB1 |
2 |
| BP |
GO:0031571 |
mitotic G1 DNA damage checkpoint signaling |
2/49 |
29/18903 |
0.0025557 |
0.0072304 |
0.0025665 |
MDM2/CDK2 |
2 |
| BP |
GO:0051938 |
L-glutamate import |
2/49 |
29/18903 |
0.0025557 |
0.0072304 |
0.0025665 |
TNF/ITGB1 |
2 |
| BP |
GO:0070977 |
bone maturation |
2/49 |
29/18903 |
0.0025557 |
0.0072304 |
0.0025665 |
IGF1/RHOA |
2 |
| BP |
GO:1902175 |
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
2/49 |
29/18903 |
0.0025557 |
0.0072304 |
0.0025665 |
AKT1/SIRT1 |
2 |
| BP |
GO:0071692 |
protein localization to extracellular region |
5/49 |
368/18903 |
0.0025698 |
0.0072634 |
0.0025782 |
TNF/IL6/IGF1/JAK2/CCL5 |
5 |
| BP |
GO:0030593 |
neutrophil chemotaxis |
3/49 |
106/18903 |
0.0026182 |
0.0073864 |
0.0026218 |
CCL5/SYK/LGALS3 |
3 |
| BP |
GO:2001252 |
positive regulation of chromosome organization |
3/49 |
106/18903 |
0.0026182 |
0.0073864 |
0.0026218 |
MAPK3/MAPK1/CDK2 |
3 |
| BP |
GO:0001818 |
negative regulation of cytokine production |
5/49 |
371/18903 |
0.0026614 |
0.0075012 |
0.0026626 |
TNF/IL6/IGF1/HGF/HMOX1 |
5 |
| BP |
GO:0015711 |
organic anion transport |
5/49 |
372/18903 |
0.0026924 |
0.0075816 |
0.0026911 |
TNF/PTGS2/ITGB1/SYK/ACE |
5 |
| BP |
GO:0030072 |
peptide hormone secretion |
4/49 |
225/18903 |
0.0027225 |
0.0076196 |
0.0027046 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0002360 |
T cell lineage commitment |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
IL6/RHOA |
2 |
| BP |
GO:0005979 |
regulation of glycogen biosynthetic process |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
AKT1/IGF1 |
2 |
| BP |
GO:0007202 |
activation of phospholipase C activity |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
EGFR/SELE |
2 |
| BP |
GO:0010464 |
regulation of mesenchymal cell proliferation |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
KDR/STAT1 |
2 |
| BP |
GO:0010962 |
regulation of glucan biosynthetic process |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
AKT1/IGF1 |
2 |
| BP |
GO:0044819 |
mitotic G1/S transition checkpoint signaling |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
MDM2/CDK2 |
2 |
| BP |
GO:0045940 |
positive regulation of steroid metabolic process |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
TNF/IGF1R |
2 |
| BP |
GO:0070498 |
interleukin-1-mediated signaling pathway |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
IL6/MAPK3 |
2 |
| BP |
GO:0071480 |
cellular response to gamma radiation |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
HRAS/MDM2 |
2 |
| BP |
GO:2000108 |
positive regulation of leukocyte apoptotic process |
2/49 |
30/18903 |
0.0027337 |
0.0076196 |
0.0027046 |
CCL5/SIRT1 |
2 |
| BP |
GO:0051341 |
regulation of oxidoreductase activity |
3/49 |
108/18903 |
0.0027607 |
0.0076875 |
0.0027287 |
TNF/AKT1/EGFR |
3 |
| BP |
GO:0046822 |
regulation of nucleocytoplasmic transport |
3/49 |
109/18903 |
0.0028337 |
0.0078762 |
0.0027957 |
PTGS2/JAK2/MAPK14 |
3 |
| BP |
GO:1903557 |
positive regulation of tumor necrosis factor superfamily cytokine production |
3/49 |
109/18903 |
0.0028337 |
0.0078762 |
0.0027957 |
IL6/JAK2/SYK |
3 |
| BP |
GO:0050767 |
regulation of neurogenesis |
5/49 |
377/18903 |
0.0028517 |
0.007919 |
0.0028109 |
TNF/IL6/KIT/ITGB1/ACE |
5 |
| BP |
GO:0045833 |
negative regulation of lipid metabolic process |
3/49 |
110/18903 |
0.0029078 |
0.0080497 |
0.0028573 |
TNF/AKT1/SIRT1 |
3 |
| BP |
GO:0001945 |
lymph vessel development |
2/49 |
31/18903 |
0.0029175 |
0.0080497 |
0.0028573 |
KDR/SYK |
2 |
| BP |
GO:0002220 |
innate immune response activating cell surface receptor signaling pathway |
2/49 |
31/18903 |
0.0029175 |
0.0080497 |
0.0028573 |
SRC/SYK |
2 |
| BP |
GO:0032148 |
activation of protein kinase B activity |
2/49 |
31/18903 |
0.0029175 |
0.0080497 |
0.0028573 |
SRC/IGF1 |
2 |
| BP |
GO:0033688 |
regulation of osteoblast proliferation |
2/49 |
31/18903 |
0.0029175 |
0.0080497 |
0.0028573 |
RHOA/IGF1R |
2 |
| BP |
GO:0045948 |
positive regulation of translational initiation |
2/49 |
31/18903 |
0.0029175 |
0.0080497 |
0.0028573 |
TNF/CCL5 |
2 |
| BP |
GO:0060055 |
angiogenesis involved in wound healing |
2/49 |
31/18903 |
0.0029175 |
0.0080497 |
0.0028573 |
TNF/KDR |
2 |
| BP |
GO:0002790 |
peptide secretion |
4/49 |
230/18903 |
0.0029465 |
0.0081223 |
0.002883 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0018107 |
peptidyl-threonine phosphorylation |
3/49 |
111/18903 |
0.0029832 |
0.0081862 |
0.0029057 |
AKT1/MAPK1/MAPK8 |
3 |
| BP |
GO:0031532 |
actin cytoskeleton reorganization |
3/49 |
111/18903 |
0.0029832 |
0.0081862 |
0.0029057 |
RHOA/KIT/HRAS |
3 |
| BP |
GO:0071347 |
cellular response to interleukin-1 |
3/49 |
111/18903 |
0.0029832 |
0.0081862 |
0.0029057 |
IL6/MAPK3/CCL5 |
3 |
| BP |
GO:0120034 |
positive regulation of plasma membrane bounded cell projection assembly |
3/49 |
111/18903 |
0.0029832 |
0.0081862 |
0.0029057 |
PIK3CA/KIT/HRAS |
3 |
| BP |
GO:1901222 |
regulation of NIK/NF-kappaB signaling |
3/49 |
111/18903 |
0.0029832 |
0.0081862 |
0.0029057 |
TNF/EGFR/RHOA |
3 |
| BP |
GO:0030900 |
forebrain development |
5/49 |
383/18903 |
0.0030517 |
0.0083665 |
0.0029697 |
EGFR/SRC/CASP3/RHOA/IGF1R |
5 |
| BP |
GO:0001516 |
prostaglandin biosynthetic process |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
PTGS2/SIRT1 |
2 |
| BP |
GO:0002758 |
innate immune response-activating signal transduction |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
SRC/SYK |
2 |
| BP |
GO:0032770 |
positive regulation of monooxygenase activity |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
TNF/AKT1 |
2 |
| BP |
GO:0034390 |
smooth muscle cell apoptotic process |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
IGF1/SIRT1 |
2 |
| BP |
GO:0034391 |
regulation of smooth muscle cell apoptotic process |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
IGF1/SIRT1 |
2 |
| BP |
GO:0043304 |
regulation of mast cell degranulation |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
SYK/HMOX1 |
2 |
| BP |
GO:0046457 |
prostanoid biosynthetic process |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
PTGS2/SIRT1 |
2 |
| BP |
GO:0050482 |
arachidonic acid secretion |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
SYK/ACE |
2 |
| BP |
GO:0060674 |
placenta blood vessel development |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
AKT1/MAPK1 |
2 |
| BP |
GO:1903715 |
regulation of aerobic respiration |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
TNF/RHOA |
2 |
| BP |
GO:1903963 |
arachidonate transport |
2/49 |
32/18903 |
0.0031068 |
0.0084332 |
0.0029934 |
SYK/ACE |
2 |
| BP |
GO:0046883 |
regulation of hormone secretion |
4/49 |
234/18903 |
0.0031345 |
0.0084936 |
0.0030148 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0006939 |
smooth muscle contraction |
3/49 |
113/18903 |
0.0031375 |
0.0084936 |
0.0030148 |
PTGS2/RHOA/KIT |
3 |
| BP |
GO:0007229 |
integrin-mediated signaling pathway |
3/49 |
113/18903 |
0.0031375 |
0.0084936 |
0.0030148 |
SRC/ITGB1/SYK |
3 |
| BP |
GO:0140694 |
non-membrane-bounded organelle assembly |
5/49 |
386/18903 |
0.0031554 |
0.0085344 |
0.0030293 |
TNF/SRC/RHOA/ITGB1/CDK2 |
5 |
| BP |
GO:0002526 |
acute inflammatory response |
3/49 |
114/18903 |
0.0032165 |
0.008684 |
0.0030824 |
TNF/IL6/PTGS2 |
3 |
| BP |
GO:0002824 |
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
3/49 |
114/18903 |
0.0032165 |
0.008684 |
0.0030824 |
TNF/IL6/JAK2 |
3 |
| BP |
GO:0034764 |
positive regulation of transmembrane transport |
4/49 |
237/18903 |
0.0032808 |
0.0088273 |
0.0031333 |
AKT1/IGF1/ITGB1/MAPK14 |
4 |
| BP |
GO:0042303 |
molting cycle |
3/49 |
115/18903 |
0.0032967 |
0.0088273 |
0.0031333 |
TNF/EGFR/PTGS2 |
3 |
| BP |
GO:0042633 |
hair cycle |
3/49 |
115/18903 |
0.0032967 |
0.0088273 |
0.0031333 |
TNF/EGFR/PTGS2 |
3 |
| BP |
GO:0046634 |
regulation of alpha-beta T cell activation |
3/49 |
115/18903 |
0.0032967 |
0.0088273 |
0.0031333 |
RHOA/JAK2/SYK |
3 |
| BP |
GO:1990748 |
cellular detoxification |
3/49 |
115/18903 |
0.0032967 |
0.0088273 |
0.0031333 |
PTGS2/MPO/NOS3 |
3 |
| BP |
GO:0002431 |
Fc receptor mediated stimulatory signaling pathway |
2/49 |
33/18903 |
0.0033018 |
0.0088273 |
0.0031333 |
SRC/SYK |
2 |
| BP |
GO:0048799 |
animal organ maturation |
2/49 |
33/18903 |
0.0033018 |
0.0088273 |
0.0031333 |
IGF1/RHOA |
2 |
| BP |
GO:0050974 |
detection of mechanical stimulus involved in sensory perception |
2/49 |
33/18903 |
0.0033018 |
0.0088273 |
0.0031333 |
TNF/KIT |
2 |
| BP |
GO:0090279 |
regulation of calcium ion import |
2/49 |
33/18903 |
0.0033018 |
0.0088273 |
0.0031333 |
ACE/LGALS3 |
2 |
| BP |
GO:1902253 |
regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
2/49 |
33/18903 |
0.0033018 |
0.0088273 |
0.0031333 |
MDM2/SIRT1 |
2 |
| BP |
GO:2000191 |
regulation of fatty acid transport |
2/49 |
33/18903 |
0.0033018 |
0.0088273 |
0.0031333 |
AKT1/SYK |
2 |
| BP |
GO:0002065 |
columnar/cuboidal epithelial cell differentiation |
3/49 |
116/18903 |
0.0033781 |
0.0090152 |
0.0032 |
AKT1/SRC/PGR |
3 |
| BP |
GO:0051702 |
biological process involved in interaction with symbiont |
3/49 |
116/18903 |
0.0033781 |
0.0090152 |
0.0032 |
GAPDH/JAK2/CCL5 |
3 |
| BP |
GO:0045088 |
regulation of innate immune response |
4/49 |
240/18903 |
0.0034317 |
0.0091502 |
0.0032479 |
SRC/CCL5/SYK/CASP8 |
4 |
| BP |
GO:0021782 |
glial cell development |
3/49 |
117/18903 |
0.0034607 |
0.0092113 |
0.0032696 |
TNF/IL6/AKT1 |
3 |
| BP |
GO:0046632 |
alpha-beta T cell differentiation |
3/49 |
117/18903 |
0.0034607 |
0.0092113 |
0.0032696 |
IL6/RHOA/SYK |
3 |
| BP |
GO:0032212 |
positive regulation of telomere maintenance via telomerase |
2/49 |
34/18903 |
0.0035024 |
0.0092649 |
0.0032886 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0033006 |
regulation of mast cell activation involved in immune response |
2/49 |
34/18903 |
0.0035024 |
0.0092649 |
0.0032886 |
SYK/HMOX1 |
2 |
| BP |
GO:0035308 |
negative regulation of protein dephosphorylation |
2/49 |
34/18903 |
0.0035024 |
0.0092649 |
0.0032886 |
TNF/LGALS3 |
2 |
| BP |
GO:0045648 |
positive regulation of erythrocyte differentiation |
2/49 |
34/18903 |
0.0035024 |
0.0092649 |
0.0032886 |
STAT1/MAPK14 |
2 |
| BP |
GO:0051973 |
positive regulation of telomerase activity |
2/49 |
34/18903 |
0.0035024 |
0.0092649 |
0.0032886 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0070570 |
regulation of neuron projection regeneration |
2/49 |
34/18903 |
0.0035024 |
0.0092649 |
0.0032886 |
HGF/IGF1R |
2 |
| BP |
GO:1901797 |
negative regulation of signal transduction by p53 class mediator |
2/49 |
34/18903 |
0.0035024 |
0.0092649 |
0.0032886 |
MDM2/SIRT1 |
2 |
| BP |
GO:0032609 |
interferon-gamma production |
3/49 |
119/18903 |
0.0036297 |
0.0095848 |
0.0034021 |
TNF/HRAS/JAK2 |
3 |
| BP |
GO:0032649 |
regulation of interferon-gamma production |
3/49 |
119/18903 |
0.0036297 |
0.0095848 |
0.0034021 |
TNF/HRAS/JAK2 |
3 |
| BP |
GO:0002719 |
negative regulation of cytokine production involved in immune response |
2/49 |
35/18903 |
0.0037085 |
0.0097503 |
0.0034609 |
TNF/HMOX1 |
2 |
| BP |
GO:0033146 |
regulation of intracellular estrogen receptor signaling pathway |
2/49 |
35/18903 |
0.0037085 |
0.0097503 |
0.0034609 |
SRC/AR |
2 |
| BP |
GO:1901099 |
negative regulation of signal transduction in absence of ligand |
2/49 |
35/18903 |
0.0037085 |
0.0097503 |
0.0034609 |
TNF/AKT1 |
2 |
| BP |
GO:2000406 |
positive regulation of T cell migration |
2/49 |
35/18903 |
0.0037085 |
0.0097503 |
0.0034609 |
RHOA/CCL5 |
2 |
| BP |
GO:2001240 |
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
2/49 |
35/18903 |
0.0037085 |
0.0097503 |
0.0034609 |
TNF/AKT1 |
2 |
| BP |
GO:0018210 |
peptidyl-threonine modification |
3/49 |
120/18903 |
0.003716 |
0.0097614 |
0.0034648 |
AKT1/MAPK1/MAPK8 |
3 |
| BP |
GO:0000077 |
DNA damage checkpoint signaling |
3/49 |
121/18903 |
0.0038036 |
0.0099741 |
0.0035403 |
MDM2/MAPK14/CDK2 |
3 |
| BP |
GO:0031623 |
receptor internalization |
3/49 |
121/18903 |
0.0038036 |
0.0099741 |
0.0035403 |
ITGB1/SYK/SELE |
3 |
| BP |
GO:0002698 |
negative regulation of immune effector process |
3/49 |
122/18903 |
0.0038924 |
0.0101628 |
0.0036073 |
TNF/HMOX1/LGALS3 |
3 |
| BP |
GO:0030278 |
regulation of ossification |
3/49 |
122/18903 |
0.0038924 |
0.0101628 |
0.0036073 |
MAPK3/MAPK1/MAPK14 |
3 |
| BP |
GO:0043500 |
muscle adaptation |
3/49 |
122/18903 |
0.0038924 |
0.0101628 |
0.0036073 |
IGF1/HMOX1/NOS3 |
3 |
| BP |
GO:0071901 |
negative regulation of protein serine/threonine kinase activity |
3/49 |
122/18903 |
0.0038924 |
0.0101628 |
0.0036073 |
AKT1/CASP3/SIRT1 |
3 |
| BP |
GO:1901989 |
positive regulation of cell cycle phase transition |
3/49 |
122/18903 |
0.0038924 |
0.0101628 |
0.0036073 |
AKT1/EGFR/MDM2 |
3 |
| BP |
GO:0033687 |
osteoblast proliferation |
2/49 |
36/18903 |
0.0039202 |
0.0102 |
0.0036205 |
RHOA/IGF1R |
2 |
| BP |
GO:0043243 |
positive regulation of protein-containing complex disassembly |
2/49 |
36/18903 |
0.0039202 |
0.0102 |
0.0036205 |
TNF/IGF1R |
2 |
| BP |
GO:0045777 |
positive regulation of blood pressure |
2/49 |
36/18903 |
0.0039202 |
0.0102 |
0.0036205 |
RHOA/ACE |
2 |
| BP |
GO:0070873 |
regulation of glycogen metabolic process |
2/49 |
36/18903 |
0.0039202 |
0.0102 |
0.0036205 |
AKT1/IGF1 |
2 |
| BP |
GO:0071695 |
anatomical structure maturation |
4/49 |
250/18903 |
0.0039689 |
0.0103176 |
0.0036623 |
IGF1/KDR/RHOA/PGR |
4 |
| BP |
GO:0072676 |
lymphocyte migration |
3/49 |
124/18903 |
0.0040739 |
0.0105816 |
0.003756 |
AKT1/RHOA/CCL5 |
3 |
| BP |
GO:0033044 |
regulation of chromosome organization |
4/49 |
252/18903 |
0.0040827 |
0.0105954 |
0.0037609 |
SRC/MAPK3/MAPK1/CDK2 |
4 |
| BP |
GO:0002068 |
glandular epithelial cell development |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
AKT1/PGR |
2 |
| BP |
GO:0003230 |
cardiac atrium development |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
MDM2/IGF1R |
2 |
| BP |
GO:0010923 |
negative regulation of phosphatase activity |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
TNF/LGALS3 |
2 |
| BP |
GO:0033144 |
negative regulation of intracellular steroid hormone receptor signaling pathway |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
RHOA/SIRT1 |
2 |
| BP |
GO:0038179 |
neurotrophin signaling pathway |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
SRC/CASP3 |
2 |
| BP |
GO:0044319 |
wound healing, spreading of cells |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
RHOA/ITGB1 |
2 |
| BP |
GO:0055023 |
positive regulation of cardiac muscle tissue growth |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
IGF1/MAPK14 |
2 |
| BP |
GO:0090505 |
epiboly involved in wound healing |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
RHOA/ITGB1 |
2 |
| BP |
GO:1902745 |
positive regulation of lamellipodium organization |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
SRC/PIK3CA |
2 |
| BP |
GO:1904358 |
positive regulation of telomere maintenance via telomere lengthening |
2/49 |
37/18903 |
0.0041374 |
0.0106456 |
0.0037787 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0015833 |
peptide transport |
4/49 |
254/18903 |
0.0041988 |
0.0107944 |
0.0038315 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0021537 |
telencephalon development |
4/49 |
255/18903 |
0.0042577 |
0.0109342 |
0.0038811 |
EGFR/CASP3/RHOA/IGF1R |
4 |
| BP |
GO:0043244 |
regulation of protein-containing complex disassembly |
3/49 |
126/18903 |
0.0042605 |
0.0109342 |
0.0038811 |
TNF/PIK3CA/IGF1R |
3 |
| BP |
GO:0003203 |
endocardial cushion morphogenesis |
2/49 |
38/18903 |
0.00436 |
0.0111329 |
0.0039517 |
MDM2/NOS3 |
2 |
| BP |
GO:0032094 |
response to food |
2/49 |
38/18903 |
0.00436 |
0.0111329 |
0.0039517 |
AKT1/MPO |
2 |
| BP |
GO:0032885 |
regulation of polysaccharide biosynthetic process |
2/49 |
38/18903 |
0.00436 |
0.0111329 |
0.0039517 |
AKT1/IGF1 |
2 |
| BP |
GO:0043516 |
regulation of DNA damage response, signal transduction by p53 class mediator |
2/49 |
38/18903 |
0.00436 |
0.0111329 |
0.0039517 |
MDM2/SIRT1 |
2 |
| BP |
GO:0090504 |
epiboly |
2/49 |
38/18903 |
0.00436 |
0.0111329 |
0.0039517 |
RHOA/ITGB1 |
2 |
| BP |
GO:0140448 |
signaling receptor ligand precursor processing |
2/49 |
38/18903 |
0.00436 |
0.0111329 |
0.0039517 |
CASP1/ACE |
2 |
| BP |
GO:0014902 |
myotube differentiation |
3/49 |
129/18903 |
0.0045499 |
0.0115882 |
0.0041133 |
IGF1/ITGB1/MAPK14 |
3 |
| BP |
GO:0031570 |
DNA integrity checkpoint signaling |
3/49 |
129/18903 |
0.0045499 |
0.0115882 |
0.0041133 |
MDM2/MAPK14/CDK2 |
3 |
| BP |
GO:0045931 |
positive regulation of mitotic cell cycle |
3/49 |
129/18903 |
0.0045499 |
0.0115882 |
0.0041133 |
AKT1/EGFR/MDM2 |
3 |
| BP |
GO:0032350 |
regulation of hormone metabolic process |
2/49 |
39/18903 |
0.0045882 |
0.0116267 |
0.0041269 |
IGF1R/NR3C1 |
2 |
| BP |
GO:0032570 |
response to progesterone |
2/49 |
39/18903 |
0.0045882 |
0.0116267 |
0.0041269 |
SRC/IGF1R |
2 |
| BP |
GO:0033028 |
myeloid cell apoptotic process |
2/49 |
39/18903 |
0.0045882 |
0.0116267 |
0.0041269 |
IL6/SIRT1 |
2 |
| BP |
GO:0045922 |
negative regulation of fatty acid metabolic process |
2/49 |
39/18903 |
0.0045882 |
0.0116267 |
0.0041269 |
AKT1/SIRT1 |
2 |
| BP |
GO:0060251 |
regulation of glial cell proliferation |
2/49 |
39/18903 |
0.0045882 |
0.0116267 |
0.0041269 |
TNF/IL6 |
2 |
| BP |
GO:0097242 |
amyloid-beta clearance |
2/49 |
39/18903 |
0.0045882 |
0.0116267 |
0.0041269 |
TNF/IGF1R |
2 |
| BP |
GO:0001558 |
regulation of cell growth |
5/49 |
422/18903 |
0.0046078 |
0.0116666 |
0.0041411 |
AKT1/EGFR/IGF1/RHOA/SIRT1 |
5 |
| BP |
GO:0031929 |
TOR signaling |
3/49 |
130/18903 |
0.004649 |
0.0117413 |
0.0041676 |
AKT1/PIK3CA/SIRT1 |
3 |
| BP |
GO:0050853 |
B cell receptor signaling pathway |
3/49 |
130/18903 |
0.004649 |
0.0117413 |
0.0041676 |
MAPK1/SYK/LCK |
3 |
| BP |
GO:1990266 |
neutrophil migration |
3/49 |
130/18903 |
0.004649 |
0.0117413 |
0.0041676 |
CCL5/SYK/LGALS3 |
3 |
| BP |
GO:0010762 |
regulation of fibroblast migration |
2/49 |
40/18903 |
0.0048217 |
0.0121368 |
0.004308 |
AKT1/ITGB1 |
2 |
| BP |
GO:0016233 |
telomere capping |
2/49 |
40/18903 |
0.0048217 |
0.0121368 |
0.004308 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0045740 |
positive regulation of DNA replication |
2/49 |
40/18903 |
0.0048217 |
0.0121368 |
0.004308 |
EGFR/CDK2 |
2 |
| BP |
GO:0098751 |
bone cell development |
2/49 |
40/18903 |
0.0048217 |
0.0121368 |
0.004308 |
SRC/KIT |
2 |
| BP |
GO:0022412 |
cellular process involved in reproduction in multicellular organism |
5/49 |
430/18903 |
0.0049862 |
0.0125298 |
0.0044475 |
AKT1/SRC/IGF1/KIT/ITGB1 |
5 |
| BP |
GO:0034329 |
cell junction assembly |
5/49 |
430/18903 |
0.0049862 |
0.0125298 |
0.0044475 |
TNF/SRC/KDR/RHOA/ACE |
5 |
| BP |
GO:0060421 |
positive regulation of heart growth |
2/49 |
41/18903 |
0.0050606 |
0.0126746 |
0.0044989 |
IGF1/MAPK14 |
2 |
| BP |
GO:0070232 |
regulation of T cell apoptotic process |
2/49 |
41/18903 |
0.0050606 |
0.0126746 |
0.0044989 |
CCL5/LGALS3 |
2 |
| BP |
GO:0070884 |
regulation of calcineurin-NFAT signaling cascade |
2/49 |
41/18903 |
0.0050606 |
0.0126746 |
0.0044989 |
TNF/IGF1 |
2 |
| BP |
GO:2000008 |
regulation of protein localization to cell surface |
2/49 |
41/18903 |
0.0050606 |
0.0126746 |
0.0044989 |
TNF/AKT1 |
2 |
| BP |
GO:0006869 |
lipid transport |
5/49 |
433/18903 |
0.0051336 |
0.0128468 |
0.00456 |
AKT1/PTGS2/SIRT1/SYK/ACE |
5 |
| BP |
GO:0010565 |
regulation of cellular ketone metabolic process |
3/49 |
136/18903 |
0.0052709 |
0.0131684 |
0.0046742 |
AKT1/PTGS2/SIRT1 |
3 |
| BP |
GO:0071333 |
cellular response to glucose stimulus |
3/49 |
136/18903 |
0.0052709 |
0.0131684 |
0.0046742 |
PIK3CA/IGF1R/ACE |
3 |
| BP |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
4/49 |
271/18903 |
0.0052771 |
0.013173 |
0.0046758 |
SRC/SIRT1/IGF1R/NR3C1 |
4 |
| BP |
GO:0010463 |
mesenchymal cell proliferation |
2/49 |
42/18903 |
0.0053049 |
0.0131769 |
0.0046772 |
KDR/STAT1 |
2 |
| BP |
GO:0014002 |
astrocyte development |
2/49 |
42/18903 |
0.0053049 |
0.0131769 |
0.0046772 |
TNF/IL6 |
2 |
| BP |
GO:0032735 |
positive regulation of interleukin-12 production |
2/49 |
42/18903 |
0.0053049 |
0.0131769 |
0.0046772 |
MAPK14/SYK |
2 |
| BP |
GO:0043029 |
T cell homeostasis |
2/49 |
42/18903 |
0.0053049 |
0.0131769 |
0.0046772 |
AKT1/CASP3 |
2 |
| BP |
GO:0106056 |
regulation of calcineurin-mediated signaling |
2/49 |
42/18903 |
0.0053049 |
0.0131769 |
0.0046772 |
TNF/IGF1 |
2 |
| BP |
GO:2000403 |
positive regulation of lymphocyte migration |
2/49 |
42/18903 |
0.0053049 |
0.0131769 |
0.0046772 |
RHOA/CCL5 |
2 |
| BP |
GO:0071331 |
cellular response to hexose stimulus |
3/49 |
138/18903 |
0.0054888 |
0.0136224 |
0.0048353 |
PIK3CA/IGF1R/ACE |
3 |
| BP |
GO:0031952 |
regulation of protein autophosphorylation |
2/49 |
43/18903 |
0.0055545 |
0.0137178 |
0.0048692 |
SRC/ACE |
2 |
| BP |
GO:0043507 |
positive regulation of JUN kinase activity |
2/49 |
43/18903 |
0.0055545 |
0.0137178 |
0.0048692 |
TNF/SYK |
2 |
| BP |
GO:0051150 |
regulation of smooth muscle cell differentiation |
2/49 |
43/18903 |
0.0055545 |
0.0137178 |
0.0048692 |
KIT/SIRT1 |
2 |
| BP |
GO:0071364 |
cellular response to epidermal growth factor stimulus |
2/49 |
43/18903 |
0.0055545 |
0.0137178 |
0.0048692 |
AKT1/EGFR |
2 |
| BP |
GO:0097009 |
energy homeostasis |
2/49 |
43/18903 |
0.0055545 |
0.0137178 |
0.0048692 |
PIK3CA/SIRT1 |
2 |
| BP |
GO:1902275 |
regulation of chromatin organization |
2/49 |
43/18903 |
0.0055545 |
0.0137178 |
0.0048692 |
PIK3CA/CDK2 |
2 |
| BP |
GO:0003158 |
endothelium development |
3/49 |
139/18903 |
0.0055997 |
0.0138181 |
0.0049048 |
TNF/KDR/RHOA |
3 |
| BP |
GO:0051348 |
negative regulation of transferase activity |
4/49 |
276/18903 |
0.0056265 |
0.0138727 |
0.0049242 |
AKT1/SRC/CASP3/SIRT1 |
4 |
| BP |
GO:0071559 |
response to transforming growth factor beta |
4/49 |
277/18903 |
0.0056981 |
0.014038 |
0.0049828 |
SRC/SIRT1/IGF1R/NR3C1 |
4 |
| BP |
GO:0002705 |
positive regulation of leukocyte mediated immunity |
3/49 |
140/18903 |
0.005712 |
0.0140492 |
0.0049868 |
TNF/IL6/KIT |
3 |
| BP |
GO:0071326 |
cellular response to monosaccharide stimulus |
3/49 |
140/18903 |
0.005712 |
0.0140492 |
0.0049868 |
PIK3CA/IGF1R/ACE |
3 |
| BP |
GO:0031063 |
regulation of histone deacetylation |
2/49 |
44/18903 |
0.0058094 |
0.0141961 |
0.0050389 |
MAPK8/SIRT1 |
2 |
| BP |
GO:0032881 |
regulation of polysaccharide metabolic process |
2/49 |
44/18903 |
0.0058094 |
0.0141961 |
0.0050389 |
AKT1/IGF1 |
2 |
| BP |
GO:0035329 |
hippo signaling |
2/49 |
44/18903 |
0.0058094 |
0.0141961 |
0.0050389 |
SRC/MAPK14 |
2 |
| BP |
GO:0045840 |
positive regulation of mitotic nuclear division |
2/49 |
44/18903 |
0.0058094 |
0.0141961 |
0.0050389 |
TNF/IGF1 |
2 |
| BP |
GO:0046640 |
regulation of alpha-beta T cell proliferation |
2/49 |
44/18903 |
0.0058094 |
0.0141961 |
0.0050389 |
JAK2/SYK |
2 |
| BP |
GO:0050856 |
regulation of T cell receptor signaling pathway |
2/49 |
44/18903 |
0.0058094 |
0.0141961 |
0.0050389 |
LCK/LGALS3 |
2 |
| BP |
GO:0072538 |
T-helper 17 type immune response |
2/49 |
44/18903 |
0.0058094 |
0.0141961 |
0.0050389 |
IL6/JAK2 |
2 |
| BP |
GO:1904706 |
negative regulation of vascular associated smooth muscle cell proliferation |
2/49 |
44/18903 |
0.0058094 |
0.0141961 |
0.0050389 |
RHOA/HMOX1 |
2 |
| BP |
GO:0032434 |
regulation of proteasomal ubiquitin-dependent protein catabolic process |
3/49 |
141/18903 |
0.0058256 |
0.0142242 |
0.0050489 |
AKT1/MDM2/CDK2 |
3 |
| BP |
GO:0042552 |
myelination |
3/49 |
142/18903 |
0.0059406 |
0.0144932 |
0.0051444 |
TNF/AKT1/HGF |
3 |
| BP |
GO:0003254 |
regulation of membrane depolarization |
2/49 |
45/18903 |
0.0060696 |
0.0147363 |
0.0052307 |
SRC/KDR |
2 |
| BP |
GO:0005978 |
glycogen biosynthetic process |
2/49 |
45/18903 |
0.0060696 |
0.0147363 |
0.0052307 |
AKT1/IGF1 |
2 |
| BP |
GO:0009250 |
glucan biosynthetic process |
2/49 |
45/18903 |
0.0060696 |
0.0147363 |
0.0052307 |
AKT1/IGF1 |
2 |
| BP |
GO:0010712 |
regulation of collagen metabolic process |
2/49 |
45/18903 |
0.0060696 |
0.0147363 |
0.0052307 |
IL6/ITGB1 |
2 |
| BP |
GO:0033003 |
regulation of mast cell activation |
2/49 |
45/18903 |
0.0060696 |
0.0147363 |
0.0052307 |
SYK/HMOX1 |
2 |
| BP |
GO:0051955 |
regulation of amino acid transport |
2/49 |
45/18903 |
0.0060696 |
0.0147363 |
0.0052307 |
TNF/ITGB1 |
2 |
| BP |
GO:0007272 |
ensheathment of neurons |
3/49 |
144/18903 |
0.0061747 |
0.0149673 |
0.0053127 |
TNF/AKT1/HGF |
3 |
| BP |
GO:0008366 |
axon ensheathment |
3/49 |
144/18903 |
0.0061747 |
0.0149673 |
0.0053127 |
TNF/AKT1/HGF |
3 |
| BP |
GO:1901987 |
regulation of cell cycle phase transition |
5/49 |
453/18903 |
0.006197 |
0.0150092 |
0.0053276 |
AKT1/EGFR/MDM2/MAPK14/CDK2 |
5 |
| BP |
GO:0045089 |
positive regulation of innate immune response |
3/49 |
145/18903 |
0.0062938 |
0.0152213 |
0.0054029 |
SRC/CCL5/SYK |
3 |
| BP |
GO:0021795 |
cerebral cortex cell migration |
2/49 |
46/18903 |
0.0063351 |
0.0152213 |
0.0054029 |
EGFR/RHOA |
2 |
| BP |
GO:0031640 |
killing of cells of another organism |
2/49 |
46/18903 |
0.0063351 |
0.0152213 |
0.0054029 |
GAPDH/SYK |
2 |
| BP |
GO:0032467 |
positive regulation of cytokinesis |
2/49 |
46/18903 |
0.0063351 |
0.0152213 |
0.0054029 |
RHOA/IGF1R |
2 |
| BP |
GO:0033173 |
calcineurin-NFAT signaling cascade |
2/49 |
46/18903 |
0.0063351 |
0.0152213 |
0.0054029 |
TNF/IGF1 |
2 |
| BP |
GO:0046006 |
regulation of activated T cell proliferation |
2/49 |
46/18903 |
0.0063351 |
0.0152213 |
0.0054029 |
CASP3/IGF1 |
2 |
| BP |
GO:0048806 |
genitalia development |
2/49 |
46/18903 |
0.0063351 |
0.0152213 |
0.0054029 |
ESR1/AR |
2 |
| BP |
GO:0070266 |
necroptotic process |
2/49 |
46/18903 |
0.0063351 |
0.0152213 |
0.0054029 |
TNF/CASP8 |
2 |
| BP |
GO:2000273 |
positive regulation of signaling receptor activity |
2/49 |
46/18903 |
0.0063351 |
0.0152213 |
0.0054029 |
JAK2/ITGB1 |
2 |
| BP |
GO:2001239 |
regulation of extrinsic apoptotic signaling pathway in absence of ligand |
2/49 |
46/18903 |
0.0063351 |
0.0152213 |
0.0054029 |
TNF/AKT1 |
2 |
| BP |
GO:0035264 |
multicellular organism growth |
3/49 |
147/18903 |
0.0065361 |
0.0156543 |
0.0055566 |
IGF1/PIK3CA/AR |
3 |
| BP |
GO:0106106 |
cold-induced thermogenesis |
3/49 |
147/18903 |
0.0065361 |
0.0156543 |
0.0055566 |
JAK2/IGF1R/SYK |
3 |
| BP |
GO:0120161 |
regulation of cold-induced thermogenesis |
3/49 |
147/18903 |
0.0065361 |
0.0156543 |
0.0055566 |
JAK2/IGF1R/SYK |
3 |
| BP |
GO:1903038 |
negative regulation of leukocyte cell-cell adhesion |
3/49 |
147/18903 |
0.0065361 |
0.0156543 |
0.0055566 |
AKT1/CASP3/LGALS3 |
3 |
| BP |
GO:0002701 |
negative regulation of production of molecular mediator of immune response |
2/49 |
47/18903 |
0.0066057 |
0.0157358 |
0.0055855 |
TNF/HMOX1 |
2 |
| BP |
GO:0008542 |
visual learning |
2/49 |
47/18903 |
0.0066057 |
0.0157358 |
0.0055855 |
KIT/ITGB1 |
2 |
| BP |
GO:0031018 |
endocrine pancreas development |
2/49 |
47/18903 |
0.0066057 |
0.0157358 |
0.0055855 |
IL6/AKT1 |
2 |
| BP |
GO:0045646 |
regulation of erythrocyte differentiation |
2/49 |
47/18903 |
0.0066057 |
0.0157358 |
0.0055855 |
STAT1/MAPK14 |
2 |
| BP |
GO:0046633 |
alpha-beta T cell proliferation |
2/49 |
47/18903 |
0.0066057 |
0.0157358 |
0.0055855 |
JAK2/SYK |
2 |
| BP |
GO:1902895 |
positive regulation of miRNA transcription |
2/49 |
47/18903 |
0.0066057 |
0.0157358 |
0.0055855 |
TNF/NR3C1 |
2 |
| BP |
GO:0043270 |
positive regulation of ion transport |
4/49 |
289/18903 |
0.0066066 |
0.0157358 |
0.0055855 |
AKT1/ITGB1/CCL5/LGALS3 |
4 |
| BP |
GO:0046879 |
hormone secretion |
4/49 |
291/18903 |
0.0067668 |
0.0161047 |
0.0057164 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0003197 |
endocardial cushion development |
2/49 |
48/18903 |
0.0068816 |
0.0162621 |
0.0057723 |
MDM2/NOS3 |
2 |
| BP |
GO:0032620 |
interleukin-17 production |
2/49 |
48/18903 |
0.0068816 |
0.0162621 |
0.0057723 |
IL6/JAK2 |
2 |
| BP |
GO:0032660 |
regulation of interleukin-17 production |
2/49 |
48/18903 |
0.0068816 |
0.0162621 |
0.0057723 |
IL6/JAK2 |
2 |
| BP |
GO:0035305 |
negative regulation of dephosphorylation |
2/49 |
48/18903 |
0.0068816 |
0.0162621 |
0.0057723 |
TNF/LGALS3 |
2 |
| BP |
GO:0035850 |
epithelial cell differentiation involved in kidney development |
2/49 |
48/18903 |
0.0068816 |
0.0162621 |
0.0057723 |
MMP9/STAT1 |
2 |
| BP |
GO:0045776 |
negative regulation of blood pressure |
2/49 |
48/18903 |
0.0068816 |
0.0162621 |
0.0057723 |
TNF/NOS3 |
2 |
| BP |
GO:0045981 |
positive regulation of nucleotide metabolic process |
2/49 |
48/18903 |
0.0068816 |
0.0162621 |
0.0057723 |
IGF1/NOS3 |
2 |
| BP |
GO:0048538 |
thymus development |
2/49 |
48/18903 |
0.0068816 |
0.0162621 |
0.0057723 |
MAPK3/MAPK1 |
2 |
| BP |
GO:1900544 |
positive regulation of purine nucleotide metabolic process |
2/49 |
48/18903 |
0.0068816 |
0.0162621 |
0.0057723 |
IGF1/NOS3 |
2 |
| BP |
GO:0007612 |
learning |
3/49 |
150/18903 |
0.0069098 |
0.0163033 |
0.0057869 |
PTGS2/KIT/ITGB1 |
3 |
| BP |
GO:0030010 |
establishment of cell polarity |
3/49 |
150/18903 |
0.0069098 |
0.0163033 |
0.0057869 |
RHOA/ITGB1/IGF1R |
3 |
| BP |
GO:0046718 |
viral entry into host cell |
3/49 |
151/18903 |
0.0070372 |
0.0165907 |
0.0058889 |
EGFR/ITGB1/CTSB |
3 |
| BP |
GO:0008206 |
bile acid metabolic process |
2/49 |
49/18903 |
0.0071626 |
0.0167631 |
0.0059501 |
KIT/SIRT1 |
2 |
| BP |
GO:0042311 |
vasodilation |
2/49 |
49/18903 |
0.0071626 |
0.0167631 |
0.0059501 |
TNF/NOS3 |
2 |
| BP |
GO:0043300 |
regulation of leukocyte degranulation |
2/49 |
49/18903 |
0.0071626 |
0.0167631 |
0.0059501 |
SYK/HMOX1 |
2 |
| BP |
GO:0043330 |
response to exogenous dsRNA |
2/49 |
49/18903 |
0.0071626 |
0.0167631 |
0.0059501 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0050798 |
activated T cell proliferation |
2/49 |
49/18903 |
0.0071626 |
0.0167631 |
0.0059501 |
CASP3/IGF1 |
2 |
| BP |
GO:0070509 |
calcium ion import |
2/49 |
49/18903 |
0.0071626 |
0.0167631 |
0.0059501 |
ACE/LGALS3 |
2 |
| BP |
GO:2000378 |
negative regulation of reactive oxygen species metabolic process |
2/49 |
49/18903 |
0.0071626 |
0.0167631 |
0.0059501 |
RHOA/MMP3 |
2 |
| BP |
GO:2000404 |
regulation of T cell migration |
2/49 |
49/18903 |
0.0071626 |
0.0167631 |
0.0059501 |
RHOA/CCL5 |
2 |
| BP |
GO:0007043 |
cell-cell junction assembly |
3/49 |
152/18903 |
0.0071659 |
0.0167631 |
0.0059501 |
TNF/RHOA/ACE |
3 |
| BP |
GO:0071322 |
cellular response to carbohydrate stimulus |
3/49 |
152/18903 |
0.0071659 |
0.0167631 |
0.0059501 |
PIK3CA/IGF1R/ACE |
3 |
| BP |
GO:0042886 |
amide transport |
4/49 |
296/18903 |
0.0071787 |
0.0167799 |
0.0059561 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0044772 |
mitotic cell cycle phase transition |
5/49 |
473/18903 |
0.0074075 |
0.017264 |
0.0061279 |
AKT1/EGFR/ITGB1/MDM2/CDK2 |
5 |
| BP |
GO:0000723 |
telomere maintenance |
3/49 |
154/18903 |
0.0074276 |
0.017264 |
0.0061279 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0008360 |
regulation of cell shape |
3/49 |
154/18903 |
0.0074276 |
0.017264 |
0.0061279 |
KDR/RHOA/KIT |
3 |
| BP |
GO:0098754 |
detoxification |
3/49 |
154/18903 |
0.0074276 |
0.017264 |
0.0061279 |
PTGS2/MPO/NOS3 |
3 |
| BP |
GO:0006692 |
prostanoid metabolic process |
2/49 |
50/18903 |
0.0074488 |
0.017264 |
0.0061279 |
PTGS2/SIRT1 |
2 |
| BP |
GO:0006693 |
prostaglandin metabolic process |
2/49 |
50/18903 |
0.0074488 |
0.017264 |
0.0061279 |
PTGS2/SIRT1 |
2 |
| BP |
GO:0007520 |
myoblast fusion |
2/49 |
50/18903 |
0.0074488 |
0.017264 |
0.0061279 |
ITGB1/MAPK14 |
2 |
| BP |
GO:0018198 |
peptidyl-cysteine modification |
2/49 |
50/18903 |
0.0074488 |
0.017264 |
0.0061279 |
GAPDH/ACE |
2 |
| BP |
GO:0030195 |
negative regulation of blood coagulation |
2/49 |
50/18903 |
0.0074488 |
0.017264 |
0.0061279 |
NOS3/PLAU |
2 |
| BP |
GO:0042304 |
regulation of fatty acid biosynthetic process |
2/49 |
50/18903 |
0.0074488 |
0.017264 |
0.0061279 |
PTGS2/SIRT1 |
2 |
| BP |
GO:0089718 |
amino acid import across plasma membrane |
2/49 |
50/18903 |
0.0074488 |
0.017264 |
0.0061279 |
TNF/ITGB1 |
2 |
| BP |
GO:0009914 |
hormone transport |
4/49 |
300/18903 |
0.0075199 |
0.0174153 |
0.0061816 |
TNF/IL6/JAK2/CCL5 |
4 |
| BP |
GO:0032368 |
regulation of lipid transport |
3/49 |
155/18903 |
0.0075606 |
0.0174827 |
0.0062055 |
AKT1/SIRT1/SYK |
3 |
| BP |
GO:1905039 |
carboxylic acid transmembrane transport |
3/49 |
155/18903 |
0.0075606 |
0.0174827 |
0.0062055 |
TNF/AKT1/ITGB1 |
3 |
| BP |
GO:1903825 |
organic acid transmembrane transport |
3/49 |
156/18903 |
0.0076949 |
0.0177797 |
0.006311 |
TNF/AKT1/ITGB1 |
3 |
| BP |
GO:0030850 |
prostate gland development |
2/49 |
51/18903 |
0.0077401 |
0.0178158 |
0.0063238 |
ESR1/AR |
2 |
| BP |
GO:0050982 |
detection of mechanical stimulus |
2/49 |
51/18903 |
0.0077401 |
0.0178158 |
0.0063238 |
TNF/KIT |
2 |
| BP |
GO:0060324 |
face development |
2/49 |
51/18903 |
0.0077401 |
0.0178158 |
0.0063238 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0097720 |
calcineurin-mediated signaling |
2/49 |
51/18903 |
0.0077401 |
0.0178158 |
0.0063238 |
TNF/IGF1 |
2 |
| BP |
GO:1900047 |
negative regulation of hemostasis |
2/49 |
51/18903 |
0.0077401 |
0.0178158 |
0.0063238 |
NOS3/PLAU |
2 |
| BP |
GO:0021700 |
developmental maturation |
4/49 |
304/18903 |
0.0078716 |
0.0181047 |
0.0064263 |
IGF1/KDR/RHOA/PGR |
4 |
| BP |
GO:0006636 |
unsaturated fatty acid biosynthetic process |
2/49 |
52/18903 |
0.0080365 |
0.0184416 |
0.0065459 |
PTGS2/SIRT1 |
2 |
| BP |
GO:0043392 |
negative regulation of DNA binding |
2/49 |
52/18903 |
0.0080365 |
0.0184416 |
0.0065459 |
JAK2/HMOX1 |
2 |
| BP |
GO:0048013 |
ephrin receptor signaling pathway |
2/49 |
52/18903 |
0.0080365 |
0.0184416 |
0.0065459 |
SRC/MMP9 |
2 |
| BP |
GO:1990845 |
adaptive thermogenesis |
3/49 |
160/18903 |
0.0082465 |
0.0189092 |
0.0067119 |
JAK2/IGF1R/SYK |
3 |
| BP |
GO:0001822 |
kidney development |
4/49 |
309/18903 |
0.0083264 |
0.0190174 |
0.0067503 |
MMP9/STAT1/RHOA/ACE |
4 |
| BP |
GO:0006111 |
regulation of gluconeogenesis |
2/49 |
53/18903 |
0.0083379 |
0.0190174 |
0.0067503 |
SIRT1/NR3C1 |
2 |
| BP |
GO:0007632 |
visual behavior |
2/49 |
53/18903 |
0.0083379 |
0.0190174 |
0.0067503 |
KIT/ITGB1 |
2 |
| BP |
GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
2/49 |
53/18903 |
0.0083379 |
0.0190174 |
0.0067503 |
RHOA/SYK |
2 |
| BP |
GO:0048260 |
positive regulation of receptor-mediated endocytosis |
2/49 |
53/18903 |
0.0083379 |
0.0190174 |
0.0067503 |
SYK/SELE |
2 |
| BP |
GO:0051155 |
positive regulation of striated muscle cell differentiation |
2/49 |
53/18903 |
0.0083379 |
0.0190174 |
0.0067503 |
IGF1/MAPK14 |
2 |
| BP |
GO:0097300 |
programmed necrotic cell death |
2/49 |
53/18903 |
0.0083379 |
0.0190174 |
0.0067503 |
TNF/CASP8 |
2 |
| BP |
GO:0050792 |
regulation of viral process |
3/49 |
162/18903 |
0.0085308 |
0.0194427 |
0.0069013 |
TNF/STAT1/CCL5 |
3 |
| BP |
GO:0022604 |
regulation of cell morphogenesis |
4/49 |
312/18903 |
0.0086074 |
0.0196025 |
0.006958 |
SRC/KDR/RHOA/KIT |
4 |
| BP |
GO:0014009 |
glial cell proliferation |
2/49 |
54/18903 |
0.0086443 |
0.0196421 |
0.006972 |
TNF/IL6 |
2 |
| BP |
GO:0030857 |
negative regulation of epithelial cell differentiation |
2/49 |
54/18903 |
0.0086443 |
0.0196421 |
0.006972 |
MMP9/STAT1 |
2 |
| BP |
GO:1902743 |
regulation of lamellipodium organization |
2/49 |
54/18903 |
0.0086443 |
0.0196421 |
0.006972 |
SRC/PIK3CA |
2 |
| BP |
GO:0040029 |
epigenetic regulation of gene expression |
3/49 |
163/18903 |
0.0086751 |
0.0196971 |
0.0069916 |
PIK3CA/SIRT1/CDK2 |
3 |
| BP |
GO:0030856 |
regulation of epithelial cell differentiation |
3/49 |
164/18903 |
0.0088208 |
0.0199979 |
0.0070983 |
TNF/MMP9/STAT1 |
3 |
| BP |
GO:0055067 |
monovalent inorganic cation homeostasis |
3/49 |
164/18903 |
0.0088208 |
0.0199979 |
0.0070983 |
MAPK3/MAPK1/ACE |
3 |
| BP |
GO:0002686 |
negative regulation of leukocyte migration |
2/49 |
55/18903 |
0.0089558 |
0.0202126 |
0.0071745 |
AKT1/HMOX1 |
2 |
| BP |
GO:0003179 |
heart valve morphogenesis |
2/49 |
55/18903 |
0.0089558 |
0.0202126 |
0.0071745 |
MDM2/NOS3 |
2 |
| BP |
GO:0010761 |
fibroblast migration |
2/49 |
55/18903 |
0.0089558 |
0.0202126 |
0.0071745 |
AKT1/ITGB1 |
2 |
| BP |
GO:0031103 |
axon regeneration |
2/49 |
55/18903 |
0.0089558 |
0.0202126 |
0.0071745 |
JAK2/IGF1R |
2 |
| BP |
GO:0042743 |
hydrogen peroxide metabolic process |
2/49 |
55/18903 |
0.0089558 |
0.0202126 |
0.0071745 |
MPO/MMP3 |
2 |
| BP |
GO:0072132 |
mesenchyme morphogenesis |
2/49 |
55/18903 |
0.0089558 |
0.0202126 |
0.0071745 |
MDM2/NOS3 |
2 |
| BP |
GO:0007281 |
germ cell development |
4/49 |
316/18903 |
0.0089917 |
0.0202784 |
0.0071979 |
AKT1/SRC/IGF1/KIT |
4 |
| BP |
GO:1902105 |
regulation of leukocyte differentiation |
4/49 |
317/18903 |
0.0090895 |
0.0204836 |
0.0072707 |
TNF/RHOA/SYK/CASP8 |
4 |
| BP |
GO:0072001 |
renal system development |
4/49 |
318/18903 |
0.0091879 |
0.0206901 |
0.007344 |
MMP9/STAT1/RHOA/ACE |
4 |
| BP |
GO:0030003 |
cellular cation homeostasis |
5/49 |
499/18903 |
0.0092175 |
0.020741 |
0.0073621 |
MAPK3/MAPK1/CCL5/HMOX1/LCK |
5 |
| BP |
GO:0003205 |
cardiac chamber development |
3/49 |
167/18903 |
0.0092667 |
0.0208176 |
0.0073893 |
MDM2/IGF1R/NOS3 |
3 |
| BP |
GO:0043331 |
response to dsRNA |
2/49 |
56/18903 |
0.0092722 |
0.0208176 |
0.0073893 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0050832 |
defense response to fungus |
2/49 |
56/18903 |
0.0092722 |
0.0208176 |
0.0073893 |
GAPDH/MPO |
2 |
| BP |
GO:0048639 |
positive regulation of developmental growth |
3/49 |
168/18903 |
0.0094182 |
0.0211296 |
0.0075 |
AKT1/IGF1/MAPK14 |
3 |
| BP |
GO:0001837 |
epithelial to mesenchymal transition |
3/49 |
169/18903 |
0.0095711 |
0.0214433 |
0.0076114 |
IL6/IGF1/HGF |
3 |
| BP |
GO:0010332 |
response to gamma radiation |
2/49 |
57/18903 |
0.0095936 |
0.0214433 |
0.0076114 |
HRAS/MDM2 |
2 |
| BP |
GO:0038066 |
p38MAPK cascade |
2/49 |
57/18903 |
0.0095936 |
0.0214433 |
0.0076114 |
HGF/MAPK14 |
2 |
| BP |
GO:0045071 |
negative regulation of viral genome replication |
2/49 |
57/18903 |
0.0095936 |
0.0214433 |
0.0076114 |
TNF/CCL5 |
2 |
| BP |
GO:0048168 |
regulation of neuronal synaptic plasticity |
2/49 |
57/18903 |
0.0095936 |
0.0214433 |
0.0076114 |
KIT/HRAS |
2 |
| BP |
GO:0050806 |
positive regulation of synaptic transmission |
3/49 |
170/18903 |
0.0097255 |
0.021706 |
0.0077046 |
TNF/PTGS2/MAPK1 |
3 |
| BP |
GO:2000058 |
regulation of ubiquitin-dependent protein catabolic process |
3/49 |
170/18903 |
0.0097255 |
0.021706 |
0.0077046 |
AKT1/MDM2/CDK2 |
3 |
| BP |
GO:0016482 |
cytosolic transport |
3/49 |
171/18903 |
0.0098814 |
0.0220375 |
0.0078223 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0048008 |
platelet-derived growth factor receptor signaling pathway |
2/49 |
58/18903 |
0.0099199 |
0.0220744 |
0.0078354 |
SRC/JAK2 |
2 |
| BP |
GO:0048016 |
inositol phosphate-mediated signaling |
2/49 |
58/18903 |
0.0099199 |
0.0220744 |
0.0078354 |
TNF/IGF1 |
2 |
| BP |
GO:0061005 |
cell differentiation involved in kidney development |
2/49 |
58/18903 |
0.0099199 |
0.0220744 |
0.0078354 |
MMP9/STAT1 |
2 |
| BP |
GO:0046394 |
carboxylic acid biosynthetic process |
4/49 |
326/18903 |
0.0100011 |
0.0222387 |
0.0078937 |
PTGS2/SIRT1/SYK/CASP1 |
4 |
| BP |
GO:0072331 |
signal transduction by p53 class mediator |
3/49 |
173/18903 |
0.0101975 |
0.0226586 |
0.0080427 |
AKT1/MDM2/SIRT1 |
3 |
| BP |
GO:0016053 |
organic acid biosynthetic process |
4/49 |
328/18903 |
0.0102115 |
0.0226731 |
0.0080479 |
PTGS2/SIRT1/SYK/CASP1 |
4 |
| BP |
GO:0002090 |
regulation of receptor internalization |
2/49 |
59/18903 |
0.0102512 |
0.0226775 |
0.0080494 |
SYK/SELE |
2 |
| BP |
GO:0002763 |
positive regulation of myeloid leukocyte differentiation |
2/49 |
59/18903 |
0.0102512 |
0.0226775 |
0.0080494 |
TNF/CASP8 |
2 |
| BP |
GO:0007566 |
embryo implantation |
2/49 |
59/18903 |
0.0102512 |
0.0226775 |
0.0080494 |
MMP9/PTGS2 |
2 |
| BP |
GO:0010574 |
regulation of vascular endothelial growth factor production |
2/49 |
59/18903 |
0.0102512 |
0.0226775 |
0.0080494 |
IL6/PTGS2 |
2 |
| BP |
GO:0051785 |
positive regulation of nuclear division |
2/49 |
59/18903 |
0.0102512 |
0.0226775 |
0.0080494 |
TNF/IGF1 |
2 |
| BP |
GO:0006937 |
regulation of muscle contraction |
3/49 |
174/18903 |
0.0103577 |
0.0228797 |
0.0081212 |
PTGS2/RHOA/KIT |
3 |
| BP |
GO:0031214 |
biomineral tissue development |
3/49 |
174/18903 |
0.0103577 |
0.0228797 |
0.0081212 |
PTGS2/IGF1/NOS3 |
3 |
| BP |
GO:0051048 |
negative regulation of secretion |
3/49 |
175/18903 |
0.0105194 |
0.0232198 |
0.008242 |
TNF/HMOX1/ACE |
3 |
| BP |
GO:0002011 |
morphogenesis of an epithelial sheet |
2/49 |
60/18903 |
0.0105872 |
0.0232842 |
0.0082648 |
RHOA/ITGB1 |
2 |
| BP |
GO:0002886 |
regulation of myeloid leukocyte mediated immunity |
2/49 |
60/18903 |
0.0105872 |
0.0232842 |
0.0082648 |
SYK/HMOX1 |
2 |
| BP |
GO:0022029 |
telencephalon cell migration |
2/49 |
60/18903 |
0.0105872 |
0.0232842 |
0.0082648 |
EGFR/RHOA |
2 |
| BP |
GO:0051353 |
positive regulation of oxidoreductase activity |
2/49 |
60/18903 |
0.0105872 |
0.0232842 |
0.0082648 |
TNF/AKT1 |
2 |
| BP |
GO:2000351 |
regulation of endothelial cell apoptotic process |
2/49 |
60/18903 |
0.0105872 |
0.0232842 |
0.0082648 |
TNF/KDR |
2 |
| BP |
GO:0030865 |
cortical cytoskeleton organization |
2/49 |
61/18903 |
0.0109282 |
0.0239815 |
0.0085123 |
TNF/RHOA |
2 |
| BP |
GO:0090311 |
regulation of protein deacetylation |
2/49 |
61/18903 |
0.0109282 |
0.0239815 |
0.0085123 |
MAPK8/SIRT1 |
2 |
| BP |
GO:1902893 |
regulation of miRNA transcription |
2/49 |
61/18903 |
0.0109282 |
0.0239815 |
0.0085123 |
TNF/NR3C1 |
2 |
| BP |
GO:0043506 |
regulation of JUN kinase activity |
2/49 |
62/18903 |
0.0112739 |
0.0246683 |
0.0087561 |
TNF/SYK |
2 |
| BP |
GO:0061614 |
miRNA transcription |
2/49 |
62/18903 |
0.0112739 |
0.0246683 |
0.0087561 |
TNF/NR3C1 |
2 |
| BP |
GO:0070228 |
regulation of lymphocyte apoptotic process |
2/49 |
62/18903 |
0.0112739 |
0.0246683 |
0.0087561 |
CCL5/LGALS3 |
2 |
| BP |
GO:1903409 |
reactive oxygen species biosynthetic process |
2/49 |
62/18903 |
0.0112739 |
0.0246683 |
0.0087561 |
RHOA/MPO |
2 |
| BP |
GO:0001933 |
negative regulation of protein phosphorylation |
4/49 |
338/18903 |
0.0113067 |
0.0247222 |
0.0087752 |
AKT1/CASP3/HGF/SIRT1 |
4 |
| BP |
GO:0050954 |
sensory perception of mechanical stimulus |
3/49 |
180/18903 |
0.01135 |
0.0247989 |
0.0088024 |
TNF/CASP3/KIT |
3 |
| BP |
GO:0110148 |
biomineralization |
3/49 |
181/18903 |
0.0115206 |
0.0251532 |
0.0089282 |
PTGS2/IGF1/NOS3 |
3 |
| BP |
GO:0021885 |
forebrain cell migration |
2/49 |
63/18903 |
0.0116244 |
0.0252701 |
0.0089697 |
EGFR/RHOA |
2 |
| BP |
GO:0032615 |
interleukin-12 production |
2/49 |
63/18903 |
0.0116244 |
0.0252701 |
0.0089697 |
MAPK14/SYK |
2 |
| BP |
GO:0032655 |
regulation of interleukin-12 production |
2/49 |
63/18903 |
0.0116244 |
0.0252701 |
0.0089697 |
MAPK14/SYK |
2 |
| BP |
GO:0046579 |
positive regulation of Ras protein signal transduction |
2/49 |
63/18903 |
0.0116244 |
0.0252701 |
0.0089697 |
SRC/IGF1 |
2 |
| BP |
GO:0050994 |
regulation of lipid catabolic process |
2/49 |
63/18903 |
0.0116244 |
0.0252701 |
0.0089697 |
TNF/AKT1 |
2 |
| BP |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
2/49 |
63/18903 |
0.0116244 |
0.0252701 |
0.0089697 |
SIRT1/LCK |
2 |
| BP |
GO:0002822 |
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
3/49 |
182/18903 |
0.0116926 |
0.0254 |
0.0090158 |
TNF/IL6/JAK2 |
3 |
| BP |
GO:0000768 |
syncytium formation by plasma membrane fusion |
2/49 |
64/18903 |
0.0119797 |
0.0259489 |
0.0092106 |
ITGB1/MAPK14 |
2 |
| BP |
GO:0002218 |
activation of innate immune response |
2/49 |
64/18903 |
0.0119797 |
0.0259489 |
0.0092106 |
SRC/SYK |
2 |
| BP |
GO:0035306 |
positive regulation of dephosphorylation |
2/49 |
64/18903 |
0.0119797 |
0.0259489 |
0.0092106 |
SRC/JAK2 |
2 |
| BP |
GO:0140253 |
cell-cell fusion |
2/49 |
64/18903 |
0.0119797 |
0.0259489 |
0.0092106 |
ITGB1/MAPK14 |
2 |
| BP |
GO:0032200 |
telomere organization |
3/49 |
185/18903 |
0.0122176 |
0.0264451 |
0.0093868 |
SRC/MAPK3/MAPK1 |
3 |
| BP |
GO:0003170 |
heart valve development |
2/49 |
65/18903 |
0.0123398 |
0.0266521 |
0.0094603 |
MDM2/NOS3 |
2 |
| BP |
GO:0015800 |
acidic amino acid transport |
2/49 |
65/18903 |
0.0123398 |
0.0266521 |
0.0094603 |
TNF/ITGB1 |
2 |
| BP |
GO:0040014 |
regulation of multicellular organism growth |
2/49 |
65/18903 |
0.0123398 |
0.0266521 |
0.0094603 |
IGF1/PIK3CA |
2 |
| BP |
GO:0000075 |
cell cycle checkpoint signaling |
3/49 |
186/18903 |
0.0123956 |
0.0267535 |
0.0094962 |
MDM2/MAPK14/CDK2 |
3 |
| BP |
GO:0002221 |
pattern recognition receptor signaling pathway |
3/49 |
187/18903 |
0.012575 |
0.0271214 |
0.0096268 |
TNF/ESR1/CASP1 |
3 |
| BP |
GO:0010812 |
negative regulation of cell-substrate adhesion |
2/49 |
66/18903 |
0.0127045 |
0.0273029 |
0.0096913 |
SRC/RHOA |
2 |
| BP |
GO:0031343 |
positive regulation of cell killing |
2/49 |
66/18903 |
0.0127045 |
0.0273029 |
0.0096913 |
MAPK8/SYK |
2 |
| BP |
GO:0033692 |
cellular polysaccharide biosynthetic process |
2/49 |
66/18903 |
0.0127045 |
0.0273029 |
0.0096913 |
AKT1/IGF1 |
2 |
| BP |
GO:0050854 |
regulation of antigen receptor-mediated signaling pathway |
2/49 |
66/18903 |
0.0127045 |
0.0273029 |
0.0096913 |
LCK/LGALS3 |
2 |
| BP |
GO:0072577 |
endothelial cell apoptotic process |
2/49 |
66/18903 |
0.0127045 |
0.0273029 |
0.0096913 |
TNF/KDR |
2 |
| BP |
GO:0002833 |
positive regulation of response to biotic stimulus |
3/49 |
188/18903 |
0.012756 |
0.0273745 |
0.0097167 |
SRC/CCL5/SYK |
3 |
| BP |
GO:0010721 |
negative regulation of cell development |
3/49 |
188/18903 |
0.012756 |
0.0273745 |
0.0097167 |
TNF/IL6/IGF1 |
3 |
| BP |
GO:0001906 |
cell killing |
3/49 |
189/18903 |
0.0129385 |
0.0277463 |
0.0098486 |
GAPDH/MAPK8/SYK |
3 |
| BP |
GO:0031638 |
zymogen activation |
2/49 |
67/18903 |
0.0130739 |
0.0279573 |
0.0099235 |
CASP8/PLAU |
2 |
| BP |
GO:0032206 |
positive regulation of telomere maintenance |
2/49 |
67/18903 |
0.0130739 |
0.0279573 |
0.0099235 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0051205 |
protein insertion into membrane |
2/49 |
67/18903 |
0.0130739 |
0.0279573 |
0.0099235 |
EGFR/MAPK8 |
2 |
| BP |
GO:0070613 |
regulation of protein processing |
2/49 |
67/18903 |
0.0130739 |
0.0279573 |
0.0099235 |
SRC/PLAU |
2 |
| BP |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
3/49 |
190/18903 |
0.0131224 |
0.028041 |
0.0099532 |
ESR1/SIRT1/HMOX1 |
3 |
| BP |
GO:1901990 |
regulation of mitotic cell cycle phase transition |
4/49 |
354/18903 |
0.0132124 |
0.0282134 |
0.0100144 |
AKT1/EGFR/MDM2/CDK2 |
4 |
| BP |
GO:0006949 |
syncytium formation |
2/49 |
68/18903 |
0.013448 |
0.0286353 |
0.0101642 |
ITGB1/MAPK14 |
2 |
| BP |
GO:0038034 |
signal transduction in absence of ligand |
2/49 |
68/18903 |
0.013448 |
0.0286353 |
0.0101642 |
TNF/AKT1 |
2 |
| BP |
GO:0042446 |
hormone biosynthetic process |
2/49 |
68/18903 |
0.013448 |
0.0286353 |
0.0101642 |
IGF1R/NR3C1 |
2 |
| BP |
GO:0097192 |
extrinsic apoptotic signaling pathway in absence of ligand |
2/49 |
68/18903 |
0.013448 |
0.0286353 |
0.0101642 |
TNF/AKT1 |
2 |
| BP |
GO:0016311 |
dephosphorylation |
4/49 |
357/18903 |
0.0135913 |
0.0289198 |
0.0102652 |
TNF/SRC/JAK2/LGALS3 |
4 |
| BP |
GO:0046578 |
regulation of Ras protein signal transduction |
3/49 |
193/18903 |
0.0136833 |
0.0290951 |
0.0103274 |
SRC/IGF1/ITGB1 |
3 |
| BP |
GO:0002260 |
lymphocyte homeostasis |
2/49 |
69/18903 |
0.0138268 |
0.0293174 |
0.0104063 |
AKT1/CASP3 |
2 |
| BP |
GO:0014015 |
positive regulation of gliogenesis |
2/49 |
69/18903 |
0.0138268 |
0.0293174 |
0.0104063 |
TNF/IL6 |
2 |
| BP |
GO:0034394 |
protein localization to cell surface |
2/49 |
69/18903 |
0.0138268 |
0.0293174 |
0.0104063 |
TNF/AKT1 |
2 |
| BP |
GO:0055021 |
regulation of cardiac muscle tissue growth |
2/49 |
69/18903 |
0.0138268 |
0.0293174 |
0.0104063 |
IGF1/MAPK14 |
2 |
| BP |
GO:0061136 |
regulation of proteasomal protein catabolic process |
3/49 |
194/18903 |
0.0138733 |
0.0293953 |
0.010434 |
AKT1/MDM2/CDK2 |
3 |
| BP |
GO:0030193 |
regulation of blood coagulation |
2/49 |
70/18903 |
0.0142101 |
0.0300879 |
0.0106798 |
NOS3/PLAU |
2 |
| BP |
GO:0032715 |
negative regulation of interleukin-6 production |
2/49 |
71/18903 |
0.0145981 |
0.0308443 |
0.0109483 |
TNF/HGF |
2 |
| BP |
GO:0051057 |
positive regulation of small GTPase mediated signal transduction |
2/49 |
71/18903 |
0.0145981 |
0.0308443 |
0.0109483 |
SRC/IGF1 |
2 |
| BP |
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
2/49 |
71/18903 |
0.0145981 |
0.0308443 |
0.0109483 |
MAPK14/SYK |
2 |
| BP |
GO:0002695 |
negative regulation of leukocyte activation |
3/49 |
198/18903 |
0.0146482 |
0.0309286 |
0.0109782 |
CASP3/HMOX1/LGALS3 |
3 |
| BP |
GO:0120032 |
regulation of plasma membrane bounded cell projection assembly |
3/49 |
199/18903 |
0.0148457 |
0.0313237 |
0.0111184 |
PIK3CA/KIT/HRAS |
3 |
| BP |
GO:0046626 |
regulation of insulin receptor signaling pathway |
2/49 |
72/18903 |
0.0149905 |
0.0314969 |
0.0111799 |
SRC/SIRT1 |
2 |
| BP |
GO:0060411 |
cardiac septum morphogenesis |
2/49 |
72/18903 |
0.0149905 |
0.0314969 |
0.0111799 |
MDM2/NOS3 |
2 |
| BP |
GO:0070265 |
necrotic cell death |
2/49 |
72/18903 |
0.0149905 |
0.0314969 |
0.0111799 |
TNF/CASP8 |
2 |
| BP |
GO:1900046 |
regulation of hemostasis |
2/49 |
72/18903 |
0.0149905 |
0.0314969 |
0.0111799 |
NOS3/PLAU |
2 |
| BP |
GO:1900076 |
regulation of cellular response to insulin stimulus |
2/49 |
72/18903 |
0.0149905 |
0.0314969 |
0.0111799 |
SRC/SIRT1 |
2 |
| BP |
GO:1903317 |
regulation of protein maturation |
2/49 |
72/18903 |
0.0149905 |
0.0314969 |
0.0111799 |
SRC/PLAU |
2 |
| BP |
GO:0030336 |
negative regulation of cell migration |
4/49 |
368/18903 |
0.0150395 |
0.0315668 |
0.0112047 |
TNF/AKT1/RHOA/HMOX1 |
4 |
| BP |
GO:0008154 |
actin polymerization or depolymerization |
3/49 |
200/18903 |
0.0150448 |
0.0315668 |
0.0112047 |
RHOA/PIK3CA/JAK2 |
3 |
| BP |
GO:0006887 |
exocytosis |
4/49 |
369/18903 |
0.0151758 |
0.0318196 |
0.0112945 |
KIT/CCL5/SYK/HMOX1 |
4 |
| BP |
GO:0000271 |
polysaccharide biosynthetic process |
2/49 |
73/18903 |
0.0153876 |
0.0321517 |
0.0114123 |
AKT1/IGF1 |
2 |
| BP |
GO:0002067 |
glandular epithelial cell differentiation |
2/49 |
73/18903 |
0.0153876 |
0.0321517 |
0.0114123 |
AKT1/PGR |
2 |
| BP |
GO:0045665 |
negative regulation of neuron differentiation |
2/49 |
73/18903 |
0.0153876 |
0.0321517 |
0.0114123 |
RHOA/ITGB1 |
2 |
| BP |
GO:0046637 |
regulation of alpha-beta T cell differentiation |
2/49 |
73/18903 |
0.0153876 |
0.0321517 |
0.0114123 |
RHOA/SYK |
2 |
| BP |
GO:0072678 |
T cell migration |
2/49 |
73/18903 |
0.0153876 |
0.0321517 |
0.0114123 |
RHOA/CCL5 |
2 |
| BP |
GO:0098739 |
import across plasma membrane |
3/49 |
202/18903 |
0.0154474 |
0.0322543 |
0.0114488 |
TNF/AKT1/ITGB1 |
3 |
| BP |
GO:0006338 |
chromatin remodeling |
4/49 |
373/18903 |
0.015729 |
0.0328195 |
0.0116494 |
ESR1/PIK3CA/SIRT1/CDK2 |
4 |
| BP |
GO:0003281 |
ventricular septum development |
2/49 |
74/18903 |
0.0157891 |
0.0328313 |
0.0116536 |
MDM2/NOS3 |
2 |
| BP |
GO:0030330 |
DNA damage response, signal transduction by p53 class mediator |
2/49 |
74/18903 |
0.0157891 |
0.0328313 |
0.0116536 |
MDM2/SIRT1 |
2 |
| BP |
GO:0042058 |
regulation of epidermal growth factor receptor signaling pathway |
2/49 |
74/18903 |
0.0157891 |
0.0328313 |
0.0116536 |
EGFR/MMP9 |
2 |
| BP |
GO:0051145 |
smooth muscle cell differentiation |
2/49 |
74/18903 |
0.0157891 |
0.0328313 |
0.0116536 |
KIT/SIRT1 |
2 |
| BP |
GO:0051298 |
centrosome duplication |
2/49 |
74/18903 |
0.0157891 |
0.0328313 |
0.0116536 |
SIRT1/CDK2 |
2 |
| BP |
GO:0031032 |
actomyosin structure organization |
3/49 |
204/18903 |
0.0158561 |
0.0329251 |
0.0116869 |
SRC/RHOA/ITGB1 |
3 |
| BP |
GO:0050864 |
regulation of B cell activation |
3/49 |
204/18903 |
0.0158561 |
0.0329251 |
0.0116869 |
IL6/CASP3/SYK |
3 |
| BP |
GO:0002460 |
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
4/49 |
375/18903 |
0.0160103 |
0.0332224 |
0.0117924 |
TNF/IL6/HRAS/JAK2 |
4 |
| BP |
GO:0005977 |
glycogen metabolic process |
2/49 |
75/18903 |
0.0161951 |
0.0335137 |
0.0118958 |
AKT1/IGF1 |
2 |
| BP |
GO:0045661 |
regulation of myoblast differentiation |
2/49 |
75/18903 |
0.0161951 |
0.0335137 |
0.0118958 |
TNF/MAPK14 |
2 |
| BP |
GO:0060337 |
type I interferon signaling pathway |
2/49 |
75/18903 |
0.0161951 |
0.0335137 |
0.0118958 |
STAT1/JAK1 |
2 |
| BP |
GO:2000242 |
negative regulation of reproductive process |
2/49 |
75/18903 |
0.0161951 |
0.0335137 |
0.0118958 |
IGF1/KIT |
2 |
| BP |
GO:1902115 |
regulation of organelle assembly |
3/49 |
207/18903 |
0.0164805 |
0.0340809 |
0.0120971 |
TNF/SRC/RHOA |
3 |
| BP |
GO:0002637 |
regulation of immunoglobulin production |
2/49 |
76/18903 |
0.0166056 |
0.0342221 |
0.0121472 |
TNF/IL6 |
2 |
| BP |
GO:0006073 |
cellular glucan metabolic process |
2/49 |
76/18903 |
0.0166056 |
0.0342221 |
0.0121472 |
AKT1/IGF1 |
2 |
| BP |
GO:0015807 |
L-amino acid transport |
2/49 |
76/18903 |
0.0166056 |
0.0342221 |
0.0121472 |
TNF/ITGB1 |
2 |
| BP |
GO:0044042 |
glucan metabolic process |
2/49 |
76/18903 |
0.0166056 |
0.0342221 |
0.0121472 |
AKT1/IGF1 |
2 |
| BP |
GO:0060420 |
regulation of heart growth |
2/49 |
76/18903 |
0.0166056 |
0.0342221 |
0.0121472 |
IGF1/MAPK14 |
2 |
| BP |
GO:0042326 |
negative regulation of phosphorylation |
4/49 |
381/18903 |
0.0168732 |
0.0347499 |
0.0123346 |
AKT1/CASP3/HGF/SIRT1 |
4 |
| BP |
GO:0045732 |
positive regulation of protein catabolic process |
3/49 |
209/18903 |
0.0169044 |
0.0347666 |
0.0123405 |
TNF/AKT1/MDM2 |
3 |
| BP |
GO:0050807 |
regulation of synapse organization |
3/49 |
209/18903 |
0.0169044 |
0.0347666 |
0.0123405 |
TNF/RHOA/MAPK14 |
3 |
| BP |
GO:0042742 |
defense response to bacterium |
4/49 |
382/18903 |
0.0170198 |
0.0349338 |
0.0123999 |
TNF/IL6/MPO/SYK |
4 |
| BP |
GO:0043297 |
apical junction assembly |
2/49 |
77/18903 |
0.0170205 |
0.0349338 |
0.0123999 |
TNF/RHOA |
2 |
| BP |
GO:0071357 |
cellular response to type I interferon |
2/49 |
77/18903 |
0.0170205 |
0.0349338 |
0.0123999 |
STAT1/JAK1 |
2 |
| BP |
GO:0007623 |
circadian rhythm |
3/49 |
210/18903 |
0.0171187 |
0.0351114 |
0.0124629 |
TNF/MAPK8/SIRT1 |
3 |
| BP |
GO:2000146 |
negative regulation of cell motility |
4/49 |
383/18903 |
0.0171673 |
0.0351871 |
0.0124898 |
TNF/AKT1/RHOA/HMOX1 |
4 |
| BP |
GO:0034637 |
cellular carbohydrate biosynthetic process |
2/49 |
78/18903 |
0.0174398 |
0.0356487 |
0.0126536 |
AKT1/IGF1 |
2 |
| BP |
GO:0043537 |
negative regulation of blood vessel endothelial cell migration |
2/49 |
78/18903 |
0.0174398 |
0.0356487 |
0.0126536 |
TNF/RHOA |
2 |
| BP |
GO:0051966 |
regulation of synaptic transmission, glutamatergic |
2/49 |
78/18903 |
0.0174398 |
0.0356487 |
0.0126536 |
TNF/PTGS2 |
2 |
| BP |
GO:1902475 |
L-alpha-amino acid transmembrane transport |
2/49 |
78/18903 |
0.0174398 |
0.0356487 |
0.0126536 |
TNF/ITGB1 |
2 |
| BP |
GO:0050803 |
regulation of synapse structure or activity |
3/49 |
215/18903 |
0.0182129 |
0.0372037 |
0.0132056 |
TNF/RHOA/MAPK14 |
3 |
| BP |
GO:0071230 |
cellular response to amino acid stimulus |
2/49 |
80/18903 |
0.0182916 |
0.0373139 |
0.0132447 |
TNF/EGFR |
2 |
| BP |
GO:1901184 |
regulation of ERBB signaling pathway |
2/49 |
80/18903 |
0.0182916 |
0.0373139 |
0.0132447 |
EGFR/MMP9 |
2 |
| BP |
GO:0006469 |
negative regulation of protein kinase activity |
3/49 |
216/18903 |
0.0184363 |
0.0375836 |
0.0133404 |
AKT1/CASP3/SIRT1 |
3 |
| BP |
GO:0044773 |
mitotic DNA damage checkpoint signaling |
2/49 |
81/18903 |
0.018724 |
0.0381186 |
0.0135303 |
MDM2/CDK2 |
2 |
| BP |
GO:0072332 |
intrinsic apoptotic signaling pathway by p53 class mediator |
2/49 |
81/18903 |
0.018724 |
0.0381186 |
0.0135303 |
MDM2/SIRT1 |
2 |
| BP |
GO:0042180 |
cellular ketone metabolic process |
3/49 |
218/18903 |
0.0188878 |
0.0384259 |
0.0136394 |
AKT1/PTGS2/SIRT1 |
3 |
| BP |
GO:0006446 |
regulation of translational initiation |
2/49 |
82/18903 |
0.0191607 |
0.0388501 |
0.01379 |
TNF/CCL5 |
2 |
| BP |
GO:0021766 |
hippocampus development |
2/49 |
82/18903 |
0.0191607 |
0.0388501 |
0.01379 |
CASP3/IGF1R |
2 |
| BP |
GO:0031016 |
pancreas development |
2/49 |
82/18903 |
0.0191607 |
0.0388501 |
0.01379 |
IL6/AKT1 |
2 |
| BP |
GO:0043242 |
negative regulation of protein-containing complex disassembly |
2/49 |
82/18903 |
0.0191607 |
0.0388501 |
0.01379 |
TNF/PIK3CA |
2 |
| BP |
GO:2001021 |
negative regulation of response to DNA damage stimulus |
2/49 |
82/18903 |
0.0191607 |
0.0388501 |
0.01379 |
MDM2/SIRT1 |
2 |
| BP |
GO:0006094 |
gluconeogenesis |
2/49 |
83/18903 |
0.0196017 |
0.039611 |
0.0140601 |
SIRT1/NR3C1 |
2 |
| BP |
GO:0006096 |
glycolytic process |
2/49 |
83/18903 |
0.0196017 |
0.039611 |
0.0140601 |
GAPDH/IGF1 |
2 |
| BP |
GO:0014032 |
neural crest cell development |
2/49 |
83/18903 |
0.0196017 |
0.039611 |
0.0140601 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0034340 |
response to type I interferon |
2/49 |
83/18903 |
0.0196017 |
0.039611 |
0.0140601 |
STAT1/JAK1 |
2 |
| BP |
GO:0061515 |
myeloid cell development |
2/49 |
83/18903 |
0.0196017 |
0.039611 |
0.0140601 |
SRC/KIT |
2 |
| BP |
GO:0006631 |
fatty acid metabolic process |
4/49 |
400/18903 |
0.0197973 |
0.0399794 |
0.0141908 |
AKT1/PTGS2/SIRT1/MAPK14 |
4 |
| BP |
GO:0006757 |
ATP generation from ADP |
2/49 |
84/18903 |
0.020047 |
0.0404024 |
0.014341 |
GAPDH/IGF1 |
2 |
| BP |
GO:0051899 |
membrane depolarization |
2/49 |
84/18903 |
0.020047 |
0.0404024 |
0.014341 |
SRC/KDR |
2 |
| BP |
GO:0097006 |
regulation of plasma lipoprotein particle levels |
2/49 |
84/18903 |
0.020047 |
0.0404024 |
0.014341 |
MPO/HMOX1 |
2 |
| BP |
GO:0008306 |
associative learning |
2/49 |
85/18903 |
0.0204965 |
0.0412532 |
0.0146429 |
KIT/ITGB1 |
2 |
| BP |
GO:0044774 |
mitotic DNA integrity checkpoint signaling |
2/49 |
85/18903 |
0.0204965 |
0.0412532 |
0.0146429 |
MDM2/CDK2 |
2 |
| BP |
GO:0019319 |
hexose biosynthetic process |
2/49 |
86/18903 |
0.0209502 |
0.042082 |
0.0149372 |
SIRT1/NR3C1 |
2 |
| BP |
GO:0032092 |
positive regulation of protein binding |
2/49 |
86/18903 |
0.0209502 |
0.042082 |
0.0149372 |
MMP9/ACE |
2 |
| BP |
GO:0033273 |
response to vitamin |
2/49 |
86/18903 |
0.0209502 |
0.042082 |
0.0149372 |
PTGS2/IGF1R |
2 |
| BP |
GO:1903050 |
regulation of proteolysis involved in protein catabolic process |
3/49 |
227/18903 |
0.0209953 |
0.0421446 |
0.0149593 |
AKT1/MDM2/CDK2 |
3 |
| BP |
GO:0045069 |
regulation of viral genome replication |
2/49 |
87/18903 |
0.0214082 |
0.0428875 |
0.015223 |
TNF/CCL5 |
2 |
| BP |
GO:2000134 |
negative regulation of G1/S transition of mitotic cell cycle |
2/49 |
87/18903 |
0.0214082 |
0.0428875 |
0.015223 |
MDM2/CDK2 |
2 |
| BP |
GO:2000243 |
positive regulation of reproductive process |
2/49 |
87/18903 |
0.0214082 |
0.0428875 |
0.015223 |
SRC/AR |
2 |
| BP |
GO:0006112 |
energy reserve metabolic process |
2/49 |
88/18903 |
0.0218702 |
0.0437841 |
0.0155413 |
AKT1/IGF1 |
2 |
| BP |
GO:0001960 |
negative regulation of cytokine-mediated signaling pathway |
2/49 |
89/18903 |
0.0223365 |
0.0446285 |
0.015841 |
IL6/CCL5 |
2 |
| BP |
GO:0048678 |
response to axon injury |
2/49 |
89/18903 |
0.0223365 |
0.0446285 |
0.015841 |
JAK2/IGF1R |
2 |
| BP |
GO:0048864 |
stem cell development |
2/49 |
89/18903 |
0.0223365 |
0.0446285 |
0.015841 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0007163 |
establishment or maintenance of cell polarity |
3/49 |
234/18903 |
0.0227207 |
0.0453662 |
0.0161029 |
RHOA/ITGB1/IGF1R |
3 |
| BP |
GO:0030641 |
regulation of cellular pH |
2/49 |
90/18903 |
0.0228068 |
0.0454477 |
0.0161318 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0046364 |
monosaccharide biosynthetic process |
2/49 |
90/18903 |
0.0228068 |
0.0454477 |
0.0161318 |
SIRT1/NR3C1 |
2 |
| BP |
GO:2000177 |
regulation of neural precursor cell proliferation |
2/49 |
90/18903 |
0.0228068 |
0.0454477 |
0.0161318 |
RHOA/ITGB1 |
2 |
| BP |
GO:0040013 |
negative regulation of locomotion |
4/49 |
419/18903 |
0.0230184 |
0.0458391 |
0.0162707 |
TNF/AKT1/RHOA/HMOX1 |
4 |
| BP |
GO:0001942 |
hair follicle development |
2/49 |
91/18903 |
0.0232812 |
0.0463012 |
0.0164348 |
TNF/EGFR |
2 |
| BP |
GO:1903351 |
cellular response to dopamine |
2/49 |
91/18903 |
0.0232812 |
0.0463012 |
0.0164348 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0060537 |
muscle tissue development |
4/49 |
422/18903 |
0.0235547 |
0.0468141 |
0.0166168 |
IGF1/RHOA/ITGB1/MAPK14 |
4 |
| BP |
GO:0002028 |
regulation of sodium ion transport |
2/49 |
92/18903 |
0.0237598 |
0.0470665 |
0.0167064 |
AKT1/NOS3 |
2 |
| BP |
GO:0009791 |
post-embryonic development |
2/49 |
92/18903 |
0.0237598 |
0.0470665 |
0.0167064 |
KDR/JAK2 |
2 |
| BP |
GO:0046031 |
ADP metabolic process |
2/49 |
92/18903 |
0.0237598 |
0.0470665 |
0.0167064 |
GAPDH/IGF1 |
2 |
| BP |
GO:0072091 |
regulation of stem cell proliferation |
2/49 |
92/18903 |
0.0237598 |
0.0470665 |
0.0167064 |
KDR/ACE |
2 |
| BP |
GO:1903350 |
response to dopamine |
2/49 |
92/18903 |
0.0237598 |
0.0470665 |
0.0167064 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0006835 |
dicarboxylic acid transport |
2/49 |
93/18903 |
0.0242423 |
0.0478995 |
0.0170021 |
TNF/ITGB1 |
2 |
| BP |
GO:0051781 |
positive regulation of cell division |
2/49 |
93/18903 |
0.0242423 |
0.0478995 |
0.0170021 |
RHOA/IGF1R |
2 |
| BP |
GO:0055017 |
cardiac muscle tissue growth |
2/49 |
93/18903 |
0.0242423 |
0.0478995 |
0.0170021 |
IGF1/MAPK14 |
2 |
| BP |
GO:0033673 |
negative regulation of kinase activity |
3/49 |
240/18903 |
0.0242597 |
0.0478995 |
0.0170021 |
AKT1/CASP3/SIRT1 |
3 |
| BP |
GO:0045333 |
cellular respiration |
3/49 |
240/18903 |
0.0242597 |
0.0478995 |
0.0170021 |
TNF/RHOA/PIK3CA |
3 |
| BP |
GO:0048738 |
cardiac muscle tissue development |
3/49 |
241/18903 |
0.0245216 |
0.0483848 |
0.0171744 |
IGF1/ITGB1/MAPK14 |
3 |
| BP |
GO:0022404 |
molting cycle process |
2/49 |
94/18903 |
0.0247289 |
0.0486346 |
0.017263 |
TNF/EGFR |
2 |
| BP |
GO:0022405 |
hair cycle process |
2/49 |
94/18903 |
0.0247289 |
0.0486346 |
0.017263 |
TNF/EGFR |
2 |
| BP |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
2/49 |
94/18903 |
0.0247289 |
0.0486346 |
0.017263 |
AKT1/MDM2 |
2 |
| BP |
GO:0060761 |
negative regulation of response to cytokine stimulus |
2/49 |
94/18903 |
0.0247289 |
0.0486346 |
0.017263 |
IL6/CCL5 |
2 |
| BP |
GO:1900542 |
regulation of purine nucleotide metabolic process |
2/49 |
94/18903 |
0.0247289 |
0.0486346 |
0.017263 |
IGF1/NOS3 |
2 |
| BP |
GO:0009205 |
purine ribonucleoside triphosphate metabolic process |
3/49 |
242/18903 |
0.0247851 |
0.0486498 |
0.0172684 |
GAPDH/IGF1/RHOA |
3 |
| BP |
GO:0032984 |
protein-containing complex disassembly |
3/49 |
242/18903 |
0.0247851 |
0.0486498 |
0.0172684 |
TNF/PIK3CA/IGF1R |
3 |
| BP |
GO:0045055 |
regulated exocytosis |
3/49 |
242/18903 |
0.0247851 |
0.0486498 |
0.0172684 |
KIT/SYK/HMOX1 |
3 |
| BP |
GO:0042391 |
regulation of membrane potential |
4/49 |
431/18903 |
0.0252091 |
0.0490882 |
0.017424 |
TNF/AKT1/SRC/KDR |
4 |
| BP |
GO:0032465 |
regulation of cytokinesis |
2/49 |
95/18903 |
0.0252195 |
0.0490882 |
0.017424 |
RHOA/IGF1R |
2 |
| BP |
GO:0098773 |
skin epidermis development |
2/49 |
95/18903 |
0.0252195 |
0.0490882 |
0.017424 |
TNF/EGFR |
2 |
| BP |
GO:0050808 |
synapse organization |
4/49 |
432/18903 |
0.0253972 |
0.0490882 |
0.017424 |
TNF/RHOA/IGF1R/MAPK14 |
4 |
| BP |
GO:0001547 |
antral ovarian follicle growth |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
ESR1 |
1 |
| BP |
GO:0002002 |
regulation of angiotensin levels in blood |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
ACE |
1 |
| BP |
GO:0002291 |
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
LGALS3 |
1 |
| BP |
GO:0003056 |
regulation of vascular associated smooth muscle contraction |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
RHOA |
1 |
| BP |
GO:0010572 |
positive regulation of platelet activation |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
JAK2 |
1 |
| BP |
GO:0015911 |
long-chain fatty acid import across plasma membrane |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
AKT1 |
1 |
| BP |
GO:0032819 |
positive regulation of natural killer cell proliferation |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
JAK2 |
1 |
| BP |
GO:0033007 |
negative regulation of mast cell activation involved in immune response |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
HMOX1 |
1 |
| BP |
GO:0033034 |
positive regulation of myeloid cell apoptotic process |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
SIRT1 |
1 |
| BP |
GO:0035747 |
natural killer cell chemotaxis |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
CCL5 |
1 |
| BP |
GO:0036093 |
germ cell proliferation |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
SRC |
1 |
| BP |
GO:0042368 |
vitamin D biosynthetic process |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
TNF |
1 |
| BP |
GO:0046886 |
positive regulation of hormone biosynthetic process |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
IGF1R |
1 |
| BP |
GO:0051933 |
amino acid neurotransmitter reuptake |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
ITGB1 |
1 |
| BP |
GO:0051974 |
negative regulation of telomerase activity |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
SRC |
1 |
| BP |
GO:0060068 |
vagina development |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
ESR1 |
1 |
| BP |
GO:0060525 |
prostate glandular acinus development |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
ESR1 |
1 |
| BP |
GO:0060768 |
regulation of epithelial cell proliferation involved in prostate gland development |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
AR |
1 |
| BP |
GO:0070091 |
glucagon secretion |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
IL6 |
1 |
| BP |
GO:0070092 |
regulation of glucagon secretion |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
IL6 |
1 |
| BP |
GO:0070099 |
regulation of chemokine-mediated signaling pathway |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
CCL5 |
1 |
| BP |
GO:0070391 |
response to lipoteichoic acid |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
MAPK14 |
1 |
| BP |
GO:0071223 |
cellular response to lipoteichoic acid |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
MAPK14 |
1 |
| BP |
GO:0071838 |
cell proliferation in bone marrow |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
ACE |
1 |
| BP |
GO:0072203 |
cell proliferation involved in metanephros development |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
STAT1 |
1 |
| BP |
GO:0090281 |
negative regulation of calcium ion import |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
ACE |
1 |
| BP |
GO:0097050 |
type B pancreatic cell apoptotic process |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
IL6 |
1 |
| BP |
GO:1902237 |
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
SIRT1 |
1 |
| BP |
GO:1903596 |
regulation of gap junction assembly |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
ACE |
1 |
| BP |
GO:1904181 |
positive regulation of membrane depolarization |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
KDR |
1 |
| BP |
GO:1990700 |
nucleolar chromatin organization |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
SIRT1 |
1 |
| BP |
GO:2000347 |
positive regulation of hepatocyte proliferation |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
TNF |
1 |
| BP |
GO:2000659 |
regulation of interleukin-1-mediated signaling pathway |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
IL6 |
1 |
| BP |
GO:2001269 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
1/49 |
10/18903 |
0.0256275 |
0.0490882 |
0.017424 |
JAK2 |
1 |
| BP |
GO:0014033 |
neural crest cell differentiation |
2/49 |
96/18903 |
0.0257141 |
0.0491291 |
0.0174385 |
MAPK3/MAPK1 |
2 |
| BP |
GO:0045807 |
positive regulation of endocytosis |
2/49 |
96/18903 |
0.0257141 |
0.0491291 |
0.0174385 |
SYK/SELE |
2 |
| BP |
GO:0046330 |
positive regulation of JNK cascade |
2/49 |
96/18903 |
0.0257141 |
0.0491291 |
0.0174385 |
TNF/HRAS |
2 |
| BP |
GO:0051153 |
regulation of striated muscle cell differentiation |
2/49 |
96/18903 |
0.0257141 |
0.0491291 |
0.0174385 |
IGF1/MAPK14 |
2 |
| BP |
GO:0045930 |
negative regulation of mitotic cell cycle |
3/49 |
246/18903 |
0.0258542 |
0.0493654 |
0.0175224 |
TNF/MDM2/CDK2 |
3 |
| BP |
GO:0006813 |
potassium ion transport |
3/49 |
247/18903 |
0.0261253 |
0.04982 |
0.0176838 |
ITGB1/NOS3/CDK2 |
3 |
| BP |
GO:0009144 |
purine nucleoside triphosphate metabolic process |
3/49 |
247/18903 |
0.0261253 |
0.04982 |
0.0176838 |
GAPDH/IGF1/RHOA |
3 |
| BP |
GO:0010596 |
negative regulation of endothelial cell migration |
2/49 |
97/18903 |
0.0262126 |
0.0499233 |
0.0177204 |
TNF/RHOA |
2 |
| BP |
GO:0043502 |
regulation of muscle adaptation |
2/49 |
97/18903 |
0.0262126 |
0.0499233 |
0.0177204 |
IGF1/NOS3 |
2 |
| CC |
GO:0045121 |
membrane raft |
16/49 |
326/19869 |
3.92E-17 |
3.46E-15 |
2.02E-15 |
TNF/EGFR/SRC/CASP3/MAPK3/PTGS2/KDR/MAPK1/JAK2/ITGB1/IGF1R/HMOX1/CASP8/LCK/NOS3/SELE |
16 |
| CC |
GO:0098857 |
membrane microdomain |
16/49 |
327/19869 |
4.12E-17 |
3.46E-15 |
2.02E-15 |
TNF/EGFR/SRC/CASP3/MAPK3/PTGS2/KDR/MAPK1/JAK2/ITGB1/IGF1R/HMOX1/CASP8/LCK/NOS3/SELE |
16 |
| CC |
GO:0005901 |
caveola |
9/49 |
82/19869 |
3.97E-13 |
2.22E-11 |
1.30E-11 |
SRC/MAPK3/PTGS2/MAPK1/JAK2/IGF1R/HMOX1/NOS3/SELE |
9 |
| CC |
GO:0044853 |
plasma membrane raft |
9/49 |
113/19869 |
7.65E-12 |
3.21E-10 |
1.87E-10 |
SRC/MAPK3/PTGS2/MAPK1/JAK2/IGF1R/HMOX1/NOS3/SELE |
9 |
| CC |
GO:0005925 |
focal adhesion |
11/49 |
422/19869 |
4.91E-09 |
1.65E-07 |
9.62E-08 |
EGFR/SRC/MAPK3/ANXA5/MAPK1/RHOA/JAK2/ITGB1/FLT1/JAK1/PLAU |
11 |
| CC |
GO:0030055 |
cell-substrate junction |
11/49 |
432/19869 |
6.27E-09 |
1.75E-07 |
1.02E-07 |
EGFR/SRC/MAPK3/ANXA5/MAPK1/RHOA/JAK2/ITGB1/FLT1/JAK1/PLAU |
11 |
| CC |
GO:1904090 |
peptidase inhibitor complex |
3/49 |
11/19869 |
2.29E-06 |
5.50E-05 |
3.21E-05 |
CASP1/CTSB/PLAU |
3 |
| CC |
GO:0009898 |
cytoplasmic side of plasma membrane |
6/49 |
173/19869 |
4.10E-06 |
8.30E-05 |
4.84E-05 |
AKT1/SRC/RHOA/KIT/SYK/LCK |
6 |
| CC |
GO:0031234 |
extrinsic component of cytoplasmic side of plasma membrane |
5/49 |
99/19869 |
4.45E-06 |
8.30E-05 |
4.84E-05 |
AKT1/SRC/RHOA/SYK/LCK |
5 |
| CC |
GO:0101002 |
ficolin-1-rich granule |
6/49 |
185/19869 |
6.02E-06 |
0.0001012 |
5.90E-05 |
MMP9/MAPK1/RHOA/MAPK14/CTSB/LGALS3 |
6 |
| CC |
GO:0098562 |
cytoplasmic side of membrane |
6/49 |
204/19869 |
1.05E-05 |
0.0001609 |
9.38E-05 |
AKT1/SRC/RHOA/KIT/SYK/LCK |
6 |
| CC |
GO:0009897 |
external side of plasma membrane |
8/49 |
462/19869 |
1.57E-05 |
0.0002199 |
0.0001282 |
TNF/KDR/ANXA5/KIT/ITGB1/ACE/CTSB/SELE |
8 |
| CC |
GO:0019897 |
extrinsic component of plasma membrane |
5/49 |
172/19869 |
6.43E-05 |
0.0008305 |
0.0004839 |
AKT1/SRC/RHOA/SYK/LCK |
5 |
| CC |
GO:0032587 |
ruffle membrane |
4/49 |
97/19869 |
9.56E-05 |
0.0011467 |
0.0006682 |
EGFR/SRC/RHOA/ITGB1 |
4 |
| CC |
GO:0019898 |
extrinsic component of membrane |
6/49 |
316/19869 |
0.0001214 |
0.0013593 |
0.0007921 |
AKT1/SRC/RHOA/PIK3CA/SYK/LCK |
6 |
| CC |
GO:0098978 |
glutamatergic synapse |
6/49 |
324/19869 |
0.0001391 |
0.0014453 |
0.0008422 |
SRC/RHOA/HRAS/JAK2/ITGB1/MAPK14 |
6 |
| CC |
GO:0031983 |
vesicle lumen |
6/49 |
327/19869 |
0.0001462 |
0.0014453 |
0.0008422 |
EGFR/IGF1/MAPK1/HGF/MPO/MAPK14 |
6 |
| CC |
GO:1904813 |
ficolin-1-rich granule lumen |
4/49 |
124/19869 |
0.0002464 |
0.0022998 |
0.0013401 |
MMP9/MAPK1/MAPK14/CTSB |
4 |
| CC |
GO:0000791 |
euchromatin |
3/49 |
60/19869 |
0.0004369 |
0.0038634 |
0.0022513 |
ESR1/JAK2/SIRT1 |
3 |
| CC |
GO:0031252 |
cell leading edge |
6/49 |
421/19869 |
0.0005651 |
0.0047468 |
0.002766 |
AKT1/EGFR/SRC/RHOA/PIK3CA/ITGB1 |
6 |
| CC |
GO:0070820 |
tertiary granule |
4/49 |
164/19869 |
0.0007099 |
0.0056792 |
0.0033093 |
MMP9/RHOA/LGALS3/PLAU |
4 |
| CC |
GO:0031143 |
pseudopodium |
2/49 |
18/19869 |
0.0008889 |
0.0067439 |
0.0039297 |
MAPK3/MAPK1 |
2 |
| CC |
GO:0031256 |
leading edge membrane |
4/49 |
177/19869 |
0.0009435 |
0.0067439 |
0.0039297 |
EGFR/SRC/RHOA/ITGB1 |
4 |
| CC |
GO:0001726 |
ruffle |
4/49 |
178/19869 |
0.0009634 |
0.0067439 |
0.0039297 |
EGFR/SRC/RHOA/ITGB1 |
4 |
| CC |
GO:0098802 |
plasma membrane signaling receptor complex |
5/49 |
319/19869 |
0.0011053 |
0.0074277 |
0.0043282 |
IL6/JAK2/ITGB1/IGF1R/SYK |
5 |
| CC |
GO:0034774 |
secretory granule lumen |
5/49 |
322/19869 |
0.0011522 |
0.0074453 |
0.0043384 |
IGF1/MAPK1/HGF/MPO/MAPK14 |
5 |
| CC |
GO:0060205 |
cytoplasmic vesicle lumen |
5/49 |
325/19869 |
0.0012006 |
0.0074706 |
0.0043532 |
IGF1/MAPK1/HGF/MPO/MAPK14 |
5 |
| CC |
GO:0030139 |
endocytic vesicle |
5/49 |
343/19869 |
0.0015233 |
0.0087614 |
0.0051053 |
EGFR/MDM2/MPO/SYK/NOS3 |
5 |
| CC |
GO:0031253 |
cell projection membrane |
5/49 |
344/19869 |
0.001543 |
0.0087614 |
0.0051053 |
EGFR/SRC/RHOA/ITGB1/ACE |
5 |
| CC |
GO:0030027 |
lamellipodium |
4/49 |
203/19869 |
0.0015645 |
0.0087614 |
0.0051053 |
AKT1/RHOA/PIK3CA/ITGB1 |
4 |
| CC |
GO:0031968 |
organelle outer membrane |
4/49 |
235/19869 |
0.0026634 |
0.0144163 |
0.0084005 |
PTGS2/HMOX1/CASP8/PGR |
4 |
| CC |
GO:0019867 |
outer membrane |
4/49 |
237/19869 |
0.002746 |
0.0144163 |
0.0084005 |
PTGS2/HMOX1/CASP8/PGR |
4 |
| CC |
GO:0031904 |
endosome lumen |
2/49 |
35/19869 |
0.0033656 |
0.0171339 |
0.009984 |
JAK2/CTSB |
2 |
| CC |
GO:0005770 |
late endosome |
4/49 |
288/19869 |
0.0054887 |
0.0264611 |
0.015419 |
EGFR/SRC/MAPK3/MAPK1 |
4 |
| CC |
GO:0001772 |
immunological synapse |
2/49 |
45/19869 |
0.0055127 |
0.0264611 |
0.015419 |
LCK/LGALS3 |
2 |
| CC |
GO:0031965 |
nuclear membrane |
4/49 |
305/19869 |
0.0067046 |
0.0303497 |
0.017685 |
GAPDH/EGFR/PTGS2/SIRT1 |
4 |
| CC |
GO:0014704 |
intercalated disc |
2/49 |
50/19869 |
0.0067681 |
0.0303497 |
0.017685 |
PIK3CA/ITGB1 |
2 |
| CC |
GO:0005635 |
nuclear envelope |
5/49 |
488/19869 |
0.0068648 |
0.0303497 |
0.017685 |
GAPDH/EGFR/MAPK3/PTGS2/SIRT1 |
5 |
| CC |
GO:0005788 |
endoplasmic reticulum lumen |
4/49 |
312/19869 |
0.0072533 |
0.0306733 |
0.0178736 |
IL6/MAPK3/PTGS2/MAPK1 |
4 |
| CC |
GO:0098636 |
protein complex involved in cell adhesion |
2/49 |
52/19869 |
0.0073032 |
0.0306733 |
0.0178736 |
ITGB1/PLAU |
2 |
| CC |
GO:0032154 |
cleavage furrow |
2/49 |
54/19869 |
0.0078568 |
0.0321939 |
0.0187596 |
RHOA/ITGB1 |
2 |
| CC |
GO:0005775 |
vacuolar lumen |
3/49 |
176/19869 |
0.0093395 |
0.0373579 |
0.0217687 |
MAPK1/MPO/CTSB |
3 |
| CC |
GO:0101003 |
ficolin-1-rich granule membrane |
2/49 |
61/19869 |
0.0099381 |
0.038828 |
0.0226253 |
RHOA/LGALS3 |
2 |
| CC |
GO:0005637 |
nuclear inner membrane |
2/49 |
63/19869 |
0.010573 |
0.0403696 |
0.0235236 |
PTGS2/SIRT1 |
2 |
| CC |
GO:0031093 |
platelet alpha granule lumen |
2/49 |
67/19869 |
0.0118951 |
0.0443658 |
0.0258523 |
IGF1/HGF |
2 |
| CC |
GO:0030666 |
endocytic vesicle membrane |
3/49 |
194/19869 |
0.0121478 |
0.0443658 |
0.0258523 |
EGFR/MDM2/NOS3 |
3 |
| CC |
GO:0032153 |
cell division site |
2/49 |
72/19869 |
0.0136443 |
0.0477551 |
0.0278272 |
RHOA/ITGB1 |
2 |
| CC |
GO:0044291 |
cell-cell contact zone |
2/49 |
72/19869 |
0.0136443 |
0.0477551 |
0.0278272 |
PIK3CA/ITGB1 |
2 |
| CC |
GO:0005741 |
mitochondrial outer membrane |
3/49 |
207/19869 |
0.0144469 |
0.0495322 |
0.0288627 |
HMOX1/CASP8/PGR |
3 |
| MF |
GO:0004713 |
protein tyrosine kinase activity |
10/49 |
138/18432 |
2.55E-12 |
6.71E-10 |
3.33E-10 |
EGFR/SRC/KDR/KIT/JAK2/IGF1R/SYK/LCK/FLT1/JAK1 |
10 |
| MF |
GO:0019902 |
phosphatase binding |
10/49 |
195/18432 |
8.00E-11 |
1.05E-08 |
5.22E-09 |
EGFR/MAPK3/STAT1/MAPK1/MAPK8/MAPK14/SYK/LCK/JAK1/LGALS3 |
10 |
| MF |
GO:0005126 |
cytokine receptor binding |
9/49 |
273/18432 |
3.68E-08 |
2.84E-06 |
1.41E-06 |
TNF/IL6/CASP3/STAT1/JAK2/CCL5/SYK/CASP8/JAK1 |
9 |
| MF |
GO:0016004 |
phospholipase activator activity |
4/49 |
14/18432 |
4.33E-08 |
2.84E-06 |
1.41E-06 |
SRC/CASP3/CCL5/LCK |
4 |
| MF |
GO:0042169 |
SH2 domain binding |
5/49 |
41/18432 |
7.51E-08 |
3.33E-06 |
1.65E-06 |
SRC/KIT/JAK2/SYK/LCK |
5 |
| MF |
GO:0004707 |
MAP kinase activity |
4/49 |
16/18432 |
7.83E-08 |
3.33E-06 |
1.65E-06 |
MAPK3/MAPK1/MAPK8/MAPK14 |
4 |
| MF |
GO:0051117 |
ATPase binding |
6/49 |
85/18432 |
9.59E-08 |
3.33E-06 |
1.65E-06 |
EGFR/SRC/ESR1/LCK/PGR/AR |
6 |
| MF |
GO:0060229 |
lipase activator activity |
4/49 |
17/18432 |
1.02E-07 |
3.33E-06 |
1.65E-06 |
SRC/CASP3/CCL5/LCK |
4 |
| MF |
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
5/49 |
45/18432 |
1.21E-07 |
3.33E-06 |
1.65E-06 |
SRC/JAK2/SYK/LCK/JAK1 |
5 |
| MF |
GO:0019903 |
protein phosphatase binding |
7/49 |
149/18432 |
1.27E-07 |
3.33E-06 |
1.65E-06 |
EGFR/STAT1/MAPK8/MAPK14/LCK/JAK1/LGALS3 |
7 |
| MF |
GO:0043274 |
phospholipase binding |
4/49 |
23/18432 |
3.76E-07 |
8.99E-06 |
4.46E-06 |
SRC/SYK/LCK/SELE |
4 |
| MF |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
5/49 |
60/18432 |
5.27E-07 |
1.15E-05 |
5.73E-06 |
EGFR/KDR/KIT/IGF1R/FLT1 |
5 |
| MF |
GO:0004175 |
endopeptidase activity |
9/49 |
426/18432 |
1.57E-06 |
3.10E-05 |
1.54E-05 |
MMP9/CASP3/CASP1/CASP8/ACE/CTSB/MMP3/MMP1/PLAU |
9 |
| MF |
GO:0004674 |
protein serine/threonine kinase activity |
9/49 |
430/18432 |
1.69E-06 |
3.10E-05 |
1.54E-05 |
AKT1/EGFR/MAPK3/MAPK1/PIK3CA/MAPK8/MAPK14/SYK/CDK2 |
9 |
| MF |
GO:0020037 |
heme binding |
6/49 |
139/18432 |
1.77E-06 |
3.10E-05 |
1.54E-05 |
SRC/PTGS2/JAK2/MPO/HMOX1/NOS3 |
6 |
| MF |
GO:0097199 |
cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
3/49 |
10/18432 |
2.09E-06 |
3.24E-05 |
1.61E-05 |
CASP3/CASP1/CASP8 |
3 |
| MF |
GO:0019199 |
transmembrane receptor protein kinase activity |
5/49 |
79/18432 |
2.09E-06 |
3.24E-05 |
1.61E-05 |
EGFR/KDR/KIT/IGF1R/FLT1 |
5 |
| MF |
GO:0046906 |
tetrapyrrole binding |
6/49 |
149/18432 |
2.65E-06 |
3.87E-05 |
1.92E-05 |
SRC/PTGS2/JAK2/MPO/HMOX1/NOS3 |
6 |
| MF |
GO:0001223 |
transcription coactivator binding |
4/49 |
40/18432 |
3.75E-06 |
5.20E-05 |
2.58E-05 |
ESR1/STAT1/PGR/AR |
4 |
| MF |
GO:0051219 |
phosphoprotein binding |
5/49 |
92/18432 |
4.45E-06 |
5.85E-05 |
2.90E-05 |
SRC/MAPK3/MAPK1/SYK/LCK |
5 |
| MF |
GO:0043560 |
insulin receptor substrate binding |
3/49 |
13/18432 |
4.96E-06 |
6.21E-05 |
3.08E-05 |
PIK3CA/JAK2/IGF1R |
3 |
| MF |
GO:0004712 |
protein serine/threonine/tyrosine kinase activity |
4/49 |
45/18432 |
6.06E-06 |
7.25E-05 |
3.60E-05 |
AKT1/MAPK3/MAPK1/MAPK14 |
4 |
| MF |
GO:0001784 |
phosphotyrosine residue binding |
4/49 |
46/18432 |
6.62E-06 |
7.58E-05 |
3.76E-05 |
MAPK3/MAPK1/SYK/LCK |
4 |
| MF |
GO:0097153 |
cysteine-type endopeptidase activity involved in apoptotic process |
3/49 |
15/18432 |
7.85E-06 |
8.61E-05 |
4.27E-05 |
CASP3/CASP1/CASP8 |
3 |
| MF |
GO:0032813 |
tumor necrosis factor receptor superfamily binding |
4/49 |
49/18432 |
8.55E-06 |
9.00E-05 |
4.46E-05 |
TNF/CASP3/STAT1/CASP8 |
4 |
| MF |
GO:0004879 |
nuclear receptor activity |
4/49 |
52/18432 |
1.09E-05 |
0.0001058 |
5.25E-05 |
ESR1/PGR/NR3C1/AR |
4 |
| MF |
GO:0098531 |
ligand-activated transcription factor activity |
4/49 |
52/18432 |
1.09E-05 |
0.0001058 |
5.25E-05 |
ESR1/PGR/NR3C1/AR |
4 |
| MF |
GO:0004708 |
MAP kinase kinase activity |
3/49 |
18/18432 |
1.40E-05 |
0.0001316 |
6.53E-05 |
MAPK3/MAPK1/MAPK14 |
3 |
| MF |
GO:0045309 |
protein phosphorylated amino acid binding |
4/49 |
58/18432 |
1.68E-05 |
0.0001526 |
7.57E-05 |
MAPK3/MAPK1/SYK/LCK |
4 |
| MF |
GO:0005158 |
insulin receptor binding |
3/49 |
22/18432 |
2.62E-05 |
0.00023 |
0.0001142 |
SRC/IGF1/IGF1R |
3 |
| MF |
GO:0097110 |
scaffold protein binding |
4/49 |
66/18432 |
2.81E-05 |
0.0002387 |
0.0001185 |
SRC/SYK/CASP8/NOS3 |
4 |
| MF |
GO:0003707 |
nuclear steroid receptor activity |
3/49 |
24/18432 |
3.44E-05 |
0.0002824 |
0.0001401 |
ESR1/PGR/NR3C1 |
3 |
| MF |
GO:0106310 |
protein serine kinase activity |
7/49 |
363/18432 |
4.57E-05 |
0.0003643 |
0.0001808 |
AKT1/MAPK3/MAPK1/PIK3CA/MAPK8/MAPK14/CDK2 |
7 |
| MF |
GO:0051019 |
mitogen-activated protein kinase binding |
3/49 |
28/18432 |
5.52E-05 |
0.000427 |
0.0002119 |
SIRT1/MAPK14/ACE |
3 |
| MF |
GO:0005178 |
integrin binding |
5/49 |
156/18432 |
5.75E-05 |
0.0004321 |
0.0002145 |
SRC/IGF1/KDR/ITGB1/SYK |
5 |
| MF |
GO:0043548 |
phosphatidylinositol 3-kinase binding |
3/49 |
30/18432 |
6.82E-05 |
0.0004979 |
0.0002471 |
JAK2/IGF1R/LCK |
3 |
| MF |
GO:0005164 |
tumor necrosis factor receptor binding |
3/49 |
31/18432 |
7.53E-05 |
0.0005353 |
0.0002657 |
TNF/STAT1/CASP8 |
3 |
| MF |
GO:0042562 |
hormone binding |
4/49 |
87/18432 |
8.34E-05 |
0.0005774 |
0.0002865 |
EGFR/IGF1R/NR3C1/AR |
4 |
| MF |
GO:0008022 |
protein C-terminus binding |
5/49 |
181/18432 |
0.0001161 |
0.0007792 |
0.0003867 |
SRC/HRAS/JAK2/SIRT1/LCK |
5 |
| MF |
GO:0042056 |
chemoattractant activity |
3/49 |
36/18432 |
0.0001185 |
0.0007792 |
0.0003867 |
CCL5/HGF/LGALS3 |
3 |
| MF |
GO:0005496 |
steroid binding |
4/49 |
101/18432 |
0.0001489 |
0.0009551 |
0.000474 |
ESR1/PGR/NR3C1/AR |
4 |
| MF |
GO:0008236 |
serine-type peptidase activity |
5/49 |
192/18432 |
0.000153 |
0.0009584 |
0.0004756 |
MMP9/ACE/MMP3/MMP1/PLAU |
5 |
| MF |
GO:0017171 |
serine hydrolase activity |
5/49 |
196/18432 |
0.0001685 |
0.0010307 |
0.0005115 |
MMP9/ACE/MMP3/MMP1/PLAU |
5 |
| MF |
GO:0001221 |
transcription coregulator binding |
4/49 |
109/18432 |
0.0001997 |
0.0011939 |
0.0005925 |
ESR1/STAT1/PGR/AR |
4 |
| MF |
GO:0004222 |
metalloendopeptidase activity |
4/49 |
112/18432 |
0.0002217 |
0.0012957 |
0.0006431 |
MMP9/ACE/MMP3/MMP1 |
4 |
| MF |
GO:0048020 |
CCR chemokine receptor binding |
3/49 |
47/18432 |
0.0002637 |
0.0015075 |
0.0007482 |
STAT1/CCL5/JAK1 |
3 |
| MF |
GO:0004197 |
cysteine-type endopeptidase activity |
4/49 |
120/18432 |
0.0002887 |
0.0016154 |
0.0008017 |
CASP3/CASP1/CASP8/CTSB |
4 |
| MF |
GO:0005131 |
growth hormone receptor binding |
2/49 |
10/18432 |
0.0003073 |
0.001684 |
0.0008358 |
JAK2/JAK1 |
2 |
| MF |
GO:0061629 |
RNA polymerase II-specific DNA-binding transcription factor binding |
6/49 |
350/18432 |
0.0003155 |
0.0016932 |
0.0008403 |
SRC/ESR1/STAT1/SIRT1/MAPK14/AR |
6 |
| MF |
GO:0030546 |
signaling receptor activator activity |
7/49 |
498/18432 |
0.000324 |
0.001704 |
0.0008457 |
TNF/IL6/EGFR/IGF1/CCL5/HGF/LGALS3 |
7 |
| MF |
GO:0019838 |
growth factor binding |
4/49 |
132/18432 |
0.0004148 |
0.0021392 |
0.0010617 |
EGFR/KDR/IGF1R/FLT1 |
4 |
| MF |
GO:0002020 |
protease binding |
4/49 |
139/18432 |
0.0005044 |
0.0025027 |
0.0012421 |
TNF/CASP3/KIT/ITGB1 |
4 |
| MF |
GO:0016922 |
nuclear receptor binding |
4/49 |
139/18432 |
0.0005044 |
0.0025027 |
0.0012421 |
SRC/ESR1/STAT1/SIRT1 |
4 |
| MF |
GO:0005518 |
collagen binding |
3/49 |
69/18432 |
0.0008177 |
0.0039826 |
0.0019766 |
MMP9/ITGB1/CTSB |
3 |
| MF |
GO:0042379 |
chemokine receptor binding |
3/49 |
71/18432 |
0.0008887 |
0.0042496 |
0.0021091 |
STAT1/CCL5/JAK1 |
3 |
| MF |
GO:0001664 |
G protein-coupled receptor binding |
5/49 |
289/18432 |
0.0009929 |
0.0046629 |
0.0023142 |
STAT1/JAK2/CCL5/ACE/JAK1 |
5 |
| MF |
GO:0004252 |
serine-type endopeptidase activity |
4/49 |
174/18432 |
0.0011672 |
0.0053857 |
0.0026729 |
MMP9/MMP3/MMP1/PLAU |
4 |
| MF |
GO:0035173 |
histone kinase activity |
2/49 |
20/18432 |
0.0012758 |
0.0057852 |
0.0028712 |
JAK2/CDK2 |
2 |
| MF |
GO:0005123 |
death receptor binding |
2/49 |
21/18432 |
0.0014077 |
0.0062751 |
0.0031143 |
CASP3/CASP8 |
2 |
| MF |
GO:0008237 |
metallopeptidase activity |
4/49 |
184/18432 |
0.0014343 |
0.0062868 |
0.0031201 |
MMP9/ACE/MMP3/MMP1 |
4 |
| MF |
GO:0008234 |
cysteine-type peptidase activity |
4/49 |
185/18432 |
0.0014631 |
0.0063082 |
0.0031307 |
CASP3/CASP1/CASP8/CTSB |
4 |
| MF |
GO:0044389 |
ubiquitin-like protein ligase binding |
5/49 |
318/18432 |
0.0015169 |
0.0064344 |
0.0031934 |
EGFR/STAT1/MDM2/CASP8/JAK1 |
5 |
| MF |
GO:0140297 |
DNA-binding transcription factor binding |
6/49 |
476/18432 |
0.0015687 |
0.0065488 |
0.0032501 |
SRC/ESR1/STAT1/SIRT1/MAPK14/AR |
6 |
| MF |
GO:0048018 |
receptor ligand activity |
6/49 |
491/18432 |
0.0018356 |
0.0075125 |
0.0037284 |
TNF/IL6/IGF1/CCL5/HGF/LGALS3 |
6 |
| MF |
GO:0045296 |
cadherin binding |
5/49 |
333/18432 |
0.0018567 |
0.0075125 |
0.0037284 |
EGFR/SRC/KDR/STAT1/ITGB1 |
5 |
| MF |
GO:0001091 |
RNA polymerase II general transcription initiation factor binding |
2/49 |
25/18432 |
0.0019974 |
0.0079595 |
0.0039503 |
ESR1/AR |
2 |
| MF |
GO:0043236 |
laminin binding |
2/49 |
28/18432 |
0.002504 |
0.0098292 |
0.0048782 |
ITGB1/LGALS3 |
2 |
| MF |
GO:0019887 |
protein kinase regulator activity |
4/49 |
218/18432 |
0.0026594 |
0.0102855 |
0.0051046 |
EGFR/CASP3/PIK3CA/CCL5 |
4 |
| MF |
GO:0030296 |
protein tyrosine kinase activator activity |
2/49 |
30/18432 |
0.0028719 |
0.0109463 |
0.0054326 |
EGFR/CCL5 |
2 |
| MF |
GO:0051427 |
hormone receptor binding |
2/49 |
32/18432 |
0.0032635 |
0.0122614 |
0.0060853 |
JAK2/JAK1 |
2 |
| MF |
GO:0030295 |
protein kinase activator activity |
3/49 |
115/18432 |
0.0035375 |
0.0131039 |
0.0065034 |
EGFR/PIK3CA/CCL5 |
3 |
| MF |
GO:0097718 |
disordered domain specific binding |
2/49 |
35/18432 |
0.0038951 |
0.0142278 |
0.0070612 |
GAPDH/MDM2 |
2 |
| MF |
GO:0019209 |
kinase activator activity |
3/49 |
121/18432 |
0.0040804 |
0.0145626 |
0.0072274 |
EGFR/PIK3CA/CCL5 |
3 |
| MF |
GO:0019207 |
kinase regulator activity |
4/49 |
246/18432 |
0.0040975 |
0.0145626 |
0.0072274 |
EGFR/CASP3/PIK3CA/CCL5 |
4 |
| MF |
GO:0030331 |
nuclear estrogen receptor binding |
2/49 |
39/18432 |
0.0048181 |
0.0168955 |
0.0083852 |
SRC/ESR1 |
2 |
| MF |
GO:0003925 |
G protein activity |
2/49 |
41/18432 |
0.0053138 |
0.0183885 |
0.0091262 |
RHOA/HRAS |
2 |
| MF |
GO:0051879 |
Hsp90 protein binding |
2/49 |
43/18432 |
0.0058319 |
0.0199194 |
0.0098859 |
KDR/NR3C1 |
2 |
| MF |
GO:0001046 |
core promoter sequence-specific DNA binding |
2/49 |
44/18432 |
0.0060993 |
0.0201271 |
0.0099891 |
STAT1/NR3C1 |
2 |
| MF |
GO:0001222 |
transcription corepressor binding |
2/49 |
44/18432 |
0.0060993 |
0.0201271 |
0.0099891 |
ESR1/STAT1 |
2 |
| MF |
GO:0070851 |
growth factor receptor binding |
3/49 |
140/18432 |
0.0061223 |
0.0201271 |
0.0099891 |
IL6/SRC/JAK2 |
3 |
| MF |
GO:0015026 |
coreceptor activity |
2/49 |
48/18432 |
0.0072238 |
0.023455 |
0.0116407 |
KDR/ITGB1 |
2 |
| MF |
GO:0031625 |
ubiquitin protein ligase binding |
4/49 |
299/18432 |
0.0081071 |
0.026002 |
0.0129047 |
EGFR/MDM2/CASP8/JAK1 |
4 |
| MF |
GO:0050661 |
NADP binding |
2/49 |
53/18432 |
0.0087507 |
0.0270756 |
0.0134376 |
GAPDH/NOS3 |
2 |
| MF |
GO:0051287 |
NAD binding |
2/49 |
53/18432 |
0.0087507 |
0.0270756 |
0.0134376 |
GAPDH/SIRT1 |
2 |
| MF |
GO:0140296 |
general transcription initiation factor binding |
2/49 |
53/18432 |
0.0087507 |
0.0270756 |
0.0134376 |
ESR1/AR |
2 |
| MF |
GO:0008083 |
growth factor activity |
3/49 |
162/18432 |
0.0091345 |
0.0279345 |
0.0138638 |
IL6/IGF1/HGF |
3 |
| MF |
GO:0004601 |
peroxidase activity |
2/49 |
55/18432 |
0.0093984 |
0.0284112 |
0.0141004 |
PTGS2/MPO |
2 |
| MF |
GO:0050840 |
extracellular matrix binding |
2/49 |
56/18432 |
0.0097301 |
0.0290796 |
0.0144322 |
ITGB1/LGALS3 |
2 |
| MF |
GO:0016684 |
oxidoreductase activity, acting on peroxide as acceptor |
2/49 |
57/18432 |
0.0100669 |
0.0297483 |
0.014764 |
PTGS2/MPO |
2 |
| MF |
GO:0140677 |
molecular function activator activity |
2/49 |
59/18432 |
0.010756 |
0.0314313 |
0.0155993 |
AKT1/NR3C1 |
2 |
| MF |
GO:0001098 |
basal transcription machinery binding |
2/49 |
61/18432 |
0.0114654 |
0.032776 |
0.0162666 |
ESR1/AR |
2 |
| MF |
GO:0001099 |
basal RNA polymerase II transcription machinery binding |
2/49 |
61/18432 |
0.0114654 |
0.032776 |
0.0162666 |
ESR1/AR |
2 |
| MF |
GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
3/49 |
179/18432 |
0.0119629 |
0.0338307 |
0.0167901 |
PTGS2/HMOX1/NOS3 |
3 |
| MF |
GO:1990841 |
promoter-specific chromatin binding |
2/49 |
63/18432 |
0.0121948 |
0.0341196 |
0.0169335 |
STAT1/SIRT1 |
2 |
| MF |
GO:0002039 |
p53 binding |
2/49 |
67/18432 |
0.0137132 |
0.0379639 |
0.0188414 |
MDM2/SIRT1 |
2 |
| MF |
GO:0019003 |
GDP binding |
2/49 |
73/18432 |
0.016136 |
0.0442058 |
0.0219392 |
RHOA/HRAS |
2 |
| MF |
GO:0001618 |
virus receptor activity |
2/49 |
77/18432 |
0.0178454 |
0.0483849 |
0.0240133 |
EGFR/ITGB1 |
2 |
| MF |
GO:0140272 |
exogenous protein binding |
2/49 |
78/18432 |
0.0182843 |
0.049069 |
0.0243528 |
EGFR/ITGB1 |
2 |
|
|