Table    Baseline data and treatment of 36 LE controls and RTX	
Patient	Group	Age
(Year)	Distribution of intestinal involvement	Abdominal CT findings
	Systemic
Involvement	SLE-DAI	Previous hormone doses (mg)	Previous immunosuppressive therapy/Control immunosuppression	RTX Dosage and Course of Treatment
	Maintenance remission regimen
	Follow-up, 
months
	
1	RTX	51	Abdomina pain，Nausea 	Bowel wall thickening of Jejunum，
Ascites，pseudo-intestinal obstruction，mesenteric leakage	Nephritis
	14	S80mg×7d+S50mg 1/d	HCQ+CTX	RTX0.5 g×4（The 1st day,the14th day,the 180th day,the 195th day）
	RTX	12	
2	RTX	24	Abdominal pain,Nausea 	Widespread dilation of jejunum and ileum, edema of intestinal wall, thickening of most intestinal wall edema, punctate congestion of most mesenteric serosal layer, mild dilation of bilateral ureters,and mild hydronephrosis of both kidneys	Nephritis
，Serositis	16	MP250mg×3d+S50mg 1/d	HCQ+MMF	RTX0.5 g×4(The 1st day,the14th day,the 180th day,the 195th day)
	RTX+HCQ	12	
3	RTX	56	Abdominal pain,Nausea 	Bowel wall thickening of Stomach
Duodenum Colon
	Hematologic，Nephritis
，seizures	22	MP500mg×3d+S45mg/d+	TAC+HCQ	RTX0.5 g×6(The 1st day,the14th day,the 180th day,the 195th day,the 450th day,the510 th day)
	RTX+HCQ	24	
4	RTX	51	Abdominal pain	Thickening and necrosis of the intestinal wall of the small intestine, intestinal perforation of the small intestine and complete intestinal obstruction	Nephritis，
Antiphospholipid syndrome	14	MP250mg×3d+S45mg/d	CTX+HCQ	RTX0.5g ×4(The 1st day，the14th day，the 180th day,the 450th day)
	RTX+HCQ	8	
5	RTX	21	diarrhoea	Bowel wall thickening of
Duodenum,Jejunum, 
Ileum and Colon,Ascites，pseudo-intestinal obstruction	Serositis
，Lupus headache,
	18	MP500mg×3d+S60mg/d	MMF+HCQ	RTX0.5g×5(The 1st day,the14th day,the 180th day,the 450th day，the 690th day)	RTX+MTX	28	
6	RTX	28	Abdominal pain,Nausea 	Bowel wall thickening of
Jejunum，Ileum
，Ascites，Perforation and Necrosis of the intestine	-	10	MP80mg×7d+S50mg/d	CTX+HCQ	RTX0.5g ×6(The 1st day,the14th day,the 180th day,the 195th day,the 450th day,the 690th day)	RTX	24	
7	RTX	59	Abdominal pain，Nausea	Bowel wall thickenin ofsmall intestine，
Colon，pseudo-intestinal obstruction	Nephritis
	16	MP80mg×7d+S45mg 1/d	MMF	RTX0.5g ×2(The 1st day，the14th day)

	HCQ+LFT	8	
8	RTX	37	Abdominal pain	Bowel wall thickening of stomach ，Ureteral dilation，mesenteric leakage，	Nephritis
，Hematologic，myalgia
	24	MP160mg×3d+S45mg 1/d	CTX+HCQ+MMF	RTX0.5g ×4(The 1st day,the14th day,the 180th day,the 195th day)
	RTX	12	
9	RTX	55	Abdominal pain ， 
Diarrhea
	Bowel wall thickening of Jejunum and Ileum, pseudo-intestinal obstruction	Nephritis,
Fever, myalgia,arthritis, 	16	MP250mg×3d+S45mg/d	CTX+HCQ+LEF	+RTX0.5 g×7(The 1st day,the14th day，he 180th day，450th day,the 690th day，840th day)	RTX	34	
10	RTX	54	Abdominal pain， 
Diarrhea，Nausea

	Bowel wall thickening of duodenum, and jejunum；mesenteric leakage	Nephritis
，Hematologic
	14	MP80mg×7d+S50mg/d	-	RTX0.5 g×4(The 1st day,the14th day，he 180th day,the 195th day)	RTX	12	
11	RTX	33	Bloating, constipation	Mesenteric edema with localized dilatation of the ascending colon,mesenteric leakage	Lupus nephritis, anemia, thrombocytopenia, acute cerebral infarction，myalgia	41	MP1g×3d+S50mg/d	HCQ+CTX	RTX0.5g ×6(The 1st day,the14th day,the 180th day,the 195th day,the 450th day,the 690th day)
	RTX	18	
12	RTX	24	Abdominal pain	Thickening of the wall of the ileum,mesenteric leakage	Lupus nephritis	14	MP80mg×7d+S45mg/d	MMF+TAC+HCQ	RTX0.5g ×4(The 1st day,the14th day,the 180th day,the 195th day)
	RTX+HCQ	12	
13	RTX	67	Bloating, abdominal pain	Thickening of the intestinal wall of the small intestine; mesenteric leakage；	Pancytopenia, hepatic vein thrombosis	15	MP500mg×3d+S45mg/d	TAC+HCQ	RTX0.5g ×4(The 1st day,the14th day,the 180th day,the 450th day)

	RTX	16	
14	RTX	30	abdominal pain	Thickening of the intestinal wall of the jejunum, ileum, and transverse colon,	Fever, arthritis, 
pleuritis, pericarditis, 
cytopenias
	15	MP250mg×3d+S45mg/d	HCQ+MMF
	RTX0.5g ×4(The 1st day,the14th day,the 180th day,the 195th day

	RTX+HCQ	13	
15	RTX	26	abdominal pain	Thickening of the bowel wall of the colon, thickening of the mesenteric arteries, mesenteric exudation	Fever, arthritis, 
pleuritis, cytopenias,lupus headache
	17	MP500mg×3d+S40mg 1/d
	HCQ+ CTX
	RTX0.5g ×4(The 1st day,the14th day,the 180th day,the 195th day)
	RTX+MTX	12	
16	RTX	40	abdominal pain,bloating	jejunal wall thickening，
mesenteric leakage	Fever, pleuritis,lupus nephritis
	15	MP250mg×3d+S60mg 1/d	HCQ+CTX	RTX0.5g ×4(The 1st day,the14th day,the 180th day,the 195th day	RTX	11	
17	Comparator
	72	Abdominal distension	Dilatation of the intestinal lumen
Thickening of the mesentery, thickening of the intestinal wall	Hematologic，Nephritis
，Serositis

	20	MP250m×3d+S40mg 1/d	MMF0.75g2/d+HCQ	-	MMF+HCQ	15	
18	Comparator
	23	Abdominal distension	Dilatation of bowel lumen,Increased mesenteric fat density
	Hematologic，Nephritis	10	S80mg×7d+S50mg/d	MMF0.75g2/d+HCQ	-	MMF+HCQ	10	
19	Comparator
	24	Abdominal pain，and vomiting	Engorgement of mesenteric vessel，mesenteric leakage，Partial thickening of the ileal wall

	Lupus headach，pancreatitis	22	MP500mg×3d+S50mg 1/d	HCQ+CTX800mg  per month	-	CTX	18	
20	Comparator
	57	Abdominal pain，and vomiting	Engorgement of mesenteric vessels，Ascites，Bowel wall thickening
	Serositis，Nephritis，
	14	MP80mg×7d+S60mg 1/d	CTX1000mg  per month+HCQ	-	CTX	48	
21	Comparator
	15	Abdominal pain，Ascites	Bowel wall thickening,Increased mesenteric fat density，mesenteric leakage，	
Hematology, acute cerebral infarction, nephritis, epilepsy
	24	MP500mg×3d+S40mg1/d	CTX1000mg  per month	-	CTX+HCQ	12	
22	Comparator
	47	Abdominal pain，and vomiting，	Bowel wall thickening,Ascites
Dilatation of bowel lumen，mesenteric leakage，
	Hemolytic anemia, alveolar hemorrhage	20	MP500mg*3d+S40mg1/d	CTX1000mg  per month	-	CTX+HCQ	16	
23	Comparator
	51	Abdominal pain，diarrhoea	Bowel wall thickening,Mesenteric vascular congestion，mesenteric leakage，	Nephritis	14	S80mg×7d+S50mg1/d	CTX 800mg  per month+HCQ	-	CTX+HCQ	14	
24	Comparator
	43	Abdominal pain，Nausea and/or vomiting，diarrhoea	Bowel wall thickening，Dilatation throughout the ureter, bilateral hydronephrosis, hydronephrosis, bilateral ureteral stenosis	-	14	MP160mg*3d+
S40mg/d	CTX1000mg  per month+HCQ	-	CTX+HCQ	19	
25	Comparator
	28	Abdominal pain	Bowel wall thickening，pseudo-intestinal obstruction，mesenteric leakage，	Nephritis，fuzzy consciousness	20	MP250mg×3d+S40mg/d	MMF0.75g2/d+HCQ	-	MMF+HCQ	24	
26	Comparator
	44	Abdominal pain，Nausea and vomiting	Bowel wall thickening，Dilatation of bowel lumen，mesenteric leakage，
	Nephritis	14	MP80mg×7d+S40mg/d	MMF0.75g 2/d+HCQ	-	MMF+HCQ	24	
27	Comparator
	30	Abdominal pain ， 
Diarrhea
	Bowel wall thickening，pancreatitis，mesenteric leakage，	Emotional disturbance, poor concentration	20	MP250mg×3d+S50mg/d	MMF0.75g 2/d +HCQ	-	MMF	18	
28	Comparator
	52	Abdominal pain 	Bowel wall thickening，
mesenteric leakage，	Lupus nephritis, anemia	10	MP80mg×7d+S60mg	CTX 1000mg per month	-	CTX	12	
29	Comparator
	23	Bloating, constipation	Thickening of the intestinal wall of the colon and sigmoid colon，Ascites
	Arthritis, rash,  nephritis	14	MP250mg×3d+S60mg	MMF0.75g 2/d+HCQ	-	MMF	16	
30	Comparator
	52	Abdominal pain，bloating 	Thickening of the walls of the jejunum, ileum and colon，Dilatation of part of the colon
	Lupus nephritis, anemia	16	MP160mg×3d+S60mg	CTX 1000mg per month	-	TAC	12	
31	Comparator
	23	Abdominal pain，diarrhea	pseudo-intestinal obstruction，Thickening of the walls of the jejunum and ileum	Fever, arthritis, anemia,Lupus nephritis, 	18	MP160mg×3d+S60mg	MMF0.75mg+HCQ	-	TAC+HCQ	18	
32	Comparator
	64	Abdominal pain，diarrhea	Thickening of the wall of the ileum，mesenteric leakage	Lupus nephritis	14	MP80mg×7d+S60mg	CTX 1000mg per month	-	CTX+HCQ	24	
33	Comparator
	30	Abdominal pain, bloating, vomiting	Incomplete small bowel obstruction,Thickening of the wall of the ileum	Platelet drop, gangrene of finger tips	20	MP250mg×3d+S60mg	MMF0.75mg+HCQ	-	MMF+HCQ	12	
34	Comparator
	34	Abdominal pain, 	Thickening of the intestinal wall of the small intestine with mesenteric vascular congestion	Lupus nephritis, headache, acute cerebral infarction	16	MP250mg×3d+S60mg	CTX1000mg per month
	- 	MMF+HCQ	12	
35	Comparator
	18	Abdominal pain,	Ureteral smooth muscle thickening, colon bowel wall thickening, target sign	White blood cell drop, fever, rash,Lupus nephritis	16	MP160mg+ S40mg 1/d	MMF0.75g 2/d
	-	MTX+HCQ	12	
36	Comparator	29	abdominal distention, acute abdominal pain	intestinal obstruction,Thickening of the walls of the jejunum and ileum	Arthritis, Raynaud's phenomenon, butterfly erythema，lupus nephritis	22	MP500mg*3d+S45mg
1/d
	HCQ+CTX1000mgper month
	-	MMF+HCQ	14	

Methylprednisolone MP, prednisone S,Methotrexate MTX, Mycophenolatemofetil MMF, TacrolimusTAC, Hydroxychloroquine sulfate HCQ, Rituximab RTX, Leflunomide LTF,Cyclosporine CTX