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["Supplementary Table 10. Cox regression results of PCA-based brain tumor subtypes."]
[]
["Combined cohort"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",0.526505565646575,1.69300586201516,0.0431580509852112,12.1994750371603,0]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",0.0117988553366187,1.01186873639865,0.00399572469948286,2.95286993574551,0.00314834583977253]
["Gender (Male vs Female)",-0.0664460733564043,0.935713374377437,0.0990544304979942,-0.670803648280526,0.502345623038335]
["Grade (III vs II)",0.720036980807891,2.05450918664859,0.16026761726976,4.49271657664903,{"v":7.03203446894562e-06,"d":"7.03E-06"}]
["Grade (IV vs II)",1.63758613409647,5.14274063118326,0.27509832089457,5.95273038661717,{"v":2.63705524083946e-09,"d":"2.64E-09"}]
["Histology (Astrocytoma vs Glioblastoma)",0.471617494325907,1.60258426889803,0.253621214750844,1.8595348768013,0.062951360428848]
["Histology (Oligoastrocytoma vs Glioblastoma)",null,null,0]
["Histology (Oligodendroglioma vs Glioblastoma)",null,null,0]
["IDH Mutation (No vs Yes)",0.389418012970523,1.47612146030257,0.126519910031051,3.07791882617486,0.00208451687725453]
["Chr 1p/19q Co-deletion (Yes vs No)",-0.667429754466623,0.513025486136916,0.238179925398983,-2.80220826061889,0.00507540978398002]
["MGMT methylation (Yes vs No)",-0.1765734971703,0.838137176180618,0.0987598785571525,-1.78790719217133,0.0737909823555881]
["Therapy (Chemotherapy vs Chemo-radio therapy)",-0.385451349292939,0.680143584590034,0.165817577492045,-2.32455060026089,0.0200960028993321]
["Therapy (Radiotherapy vs Chemo-radio therapy)",0.296905368952523,1.34568794956232,0.135098755484762,2.19769136945168,0.0279711070010372]
["Sample type (Recurrent vs Primary)",0.940035309589195,2.56007181181737,0.111534670960963,8.42818920332139,0]
["Sample type (Secondary vs Primary)",1.37531078839633,3.95630610590175,0.230176396753385,5.97502961986959,{"v":2.30048380345238e-09,"d":"2.30E-09"}]
["Subtype (C2 vs C1)",0.536748286041581,1.71043596111546,0.124071437120158,4.32612290548196,{"v":1.51756768743683e-05,"d":"1.52E-05"}]
[" "]
["CGGA-C"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",-1.92186346674515,0.14633401932072,0.168255682114298,-11.4222797268719,0]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",0.0204029064087034,1.02061246850241,0.00753542863410376,2.70759732450576,0.00677721963308575]
["Gender (Male vs Female)",-0.138358136851202,0.870786775061014,0.165598565310051,-0.835503233932932,0.40343442686902]
["Grade (III vs II)",0.703598833787821,2.0210129250767,0.280562428059844,2.50781559973434,0.0121480044194681]
["Grade (IV vs II)",1.64327496637862,5.17208019490744,0.578072601865085,2.8426792085921,0.00447360728464163]
["Histology (Astrocytoma vs Glioblastoma)",0.479863579872891,1.61585395215478,0.5380977646516,0.89177768687366,0.372512103778944]
["Histology (Oligodendroglioma vs Glioblastoma)",null,null,0]
["IDH Mutation (No vs Yes)",-0.168145208753166,0.845231090820297,0.228227128694841,-0.736745056184754,0.46127740147875]
["Therapy (Chemotherapy vs Chemo-radio therapy)",-0.364960396675125,0.694224143917875,0.244932616919559,-1.49004408341003,0.136212645160724]
["Therapy (Radiotherapy vs Chemo-radio therapy)",0.352738749660731,1.42295934625767,0.211990976638071,1.66393284872193,0.0961258496380104]
["Chr 1p/19q Co-deletion (Yes vs No)",-0.84589496063655,0.429173093260651,0.457232809789736,-1.8500311931367,0.0643090538619949]
["MGMT methylation (Yes vs No)",-0.321619445986664,0.724974029617235,0.178779591331074,-1.79897181547457,0.0720231391858156]
["Sample type (Recurrent vs Primary)",0.954207790304771,2.59661270613162,0.237844063887151,4.01190500494269,{"v":6.02307377537414e-05,"d":"6.02E-05"}]
["Sample type (Secondary vs Primary)",1.52942838669054,4.61553776529462,0.290446787635193,5.26577828297942,{"v":1.39596680992504e-07,"d":"1.40E-07"}]
["Subtype (C2 vs C1)",-1.06145177317606,0.345953200004302,0.240658968476996,-4.41060551324318,{"v":1.03081961739804e-05,"d":"1.03E-05"}]
[" "]
["CGGA-B"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",0.109154294472548,1.115334427003,0.166934467020954,0.653875118904273,0.513192265080552]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",0.00927330566430877,1.00931643598039,0.00504889184251709,1.83670119177788,0.0662540192422549]
["Gender (Male vs Female)",0.126331854607479,1.13465864751148,0.137068370686472,0.921670360381304,0.356700545413816]
["Grade (III vs II)",0.953429798714317,2.59459334890591,0.23610816065559,4.03810607844716,{"v":5.38844867129518e-05,"d":"5.39E-05"}]
["Grade (IV vs II)",1.38803441478966,4.00696627376651,0.256900510025352,5.40300373344018,{"v":6.55340951505323e-08,"d":"6.55E-08"}]
["HistologyGlioblastoma",null,null,0]
["Histology (Oligoastrocytoma vs Glioblastoma)",null,null,0]
["Histology (Oligodendroglioma vs Glioblastoma)",-0.36983483209568,0.690848427201474,0.303282999587527,-1.21943805817888,0.222677972377503]
["IDH Mutation (No vs Yes)",0.687816497538346,1.98936699971294,0.175078404947858,3.92861985316346,{"v":8.54347684363654e-05,"d":"8.54E-05"}]
["Therapy (Chemotherapy vs Chemo-radio therapy)",0.0388657499000356,1.03963090372831,0.236626121569553,0.164249617253738,0.869534642534373]
["Therapy (Radiotherapy vs Chemo-radio therapy)",0.438925692390467,1.55104002902863,0.21762850184948,2.01685757453794,0.0437103785682639]
["Chr 1p/19q Co-deletion (Yes vs No)",-0.63594799561601,0.529433349848015,0.297903438693862,-2.13474540073885,0.0327818123209098]
["MGMT methylation (Yes vs No)",-0.130708174064953,0.877473806644904,0.135197544363076,-0.96679399526616,0.333647026855911]
["Sample type (Recurrent vs Primary)",0.891982868237575,2.43996298287601,0.137402679557894,6.49174289109656,{"v":8.48490167015825e-11,"d":"8.48E-11"}]
["Subtype (C2 vs C1)",2.04253681320648,7.7101436049542,1.07800561824714,1.89473670510891,0.058127292369321]
[" "]
["PBCA-US"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",1.92152273980908,6.83135292630627,0.350218002876865,5.48664752818169,{"v":4.09633331699411e-08,"d":"4.10E-08"}]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",-0.0192748638273054,0.980909708588742,0.0228656679515593,-0.842960890892802,0.399250316859683]
["Gender (Male vs Female)",0.42357628075681,1.52741426183518,0.28692610547293,1.47625563752257,0.139875278512777]
["Subtype (C2 vs C1)",2.11067708308266,8.25382792035701,0.371974314970915,5.67425490990606,{"v":1.39293585554867e-08,"d":"1.39E-08"}]
[" "]
["CGGA-D"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",-1.38637740999631,0.24997923864301,0.161288334775201,-8.59564587810153,0]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",-0.0224978650408637,0.977753324654502,0.0211352394169826,-1.06447173826601,0.287115050653702]
["Gender (Male vs Female)",-0.95156739218204,0.386135323406627,0.379213710899779,-2.50931694933764,0.0120964892413136]
["Grade (III vs II)",-0.324587417814762,0.72282551706076,0.655369030670153,-0.495274269342348,0.620406531214003]
["Grade (IV vs II)",-0.00901075710652898,0.991029718103294,1.19815604549146,-0.00752052050351504,0.993999549363574]
["Histology (Astrocytoma vs Glioblastoma)",0.678112478380209,1.97015550932925,1.19213860833236,0.568820163729781,0.569478189374321]
["Histology (Oligoastrocytoma vs Glioblastoma)",null,null,0]
["Histology (Oligodendroglioma vs Glioblastoma)",null,null,0]
["IDH Mutation (No vs Yes)",0.577910927100478,1.78231116089167,0.538243131774636,1.07369865583803,0.282957764018357]
["Therapy (Radiotherapy vs Chemo-radio therapy)",0.479774921877395,1.61571070013268,0.465255397900376,1.03120764217362,0.302443457663849]
["Chr 1p/19q Co-deletion (Yes vs No)",0.269347375791624,1.30910981512886,1.44620726692504,0.186243965129782,0.852253447865015]
["MGMT methylation (Yes vs No)",-0.168996969166142,0.844511462956091,0.3831628870531,-0.441057771711387,0.659171173649469]
["Sample type (Recurrent vs Primary)",0.988457595575355,2.68708669998488,0.510319818641471,1.93693750363593,0.0527529833317176]
["Sample type (Secondary vs Primary)",1.51164086689842,4.53416465435219,0.659745705590058,2.29124775514294,0.0219490883890638]
["Subtype (C2 vs C1)",-1.76186334291606,0.171724583733288,0.584697655837874,-3.01328956140812,0.00258432204650727]
[" "]
["GSE16011"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",1.28113648003634,3.60072955838178,0.154131027319251,8.31199598366868,{"v":1.11022302462516e-16,"d":"1.11E-16"}]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",0.0350611852667754,1.03568307540632,0.00900666649929883,3.89280376591105,{"v":9.90923047364811e-05,"d":"9.91E-05"}]
["Gender (Male vs Female)",0.0924329879878964,1.09683963766643,0.24041218989144,0.38447712667829,0.700624845836349]
["Grade (III vs II)",-0.325340761473987,0.722281186100638,0.419262959115601,-0.775982600896262,0.437759259143537]
["Grade (IV vs II)",-0.113066067078856,0.893091654210119,0.47558566280398,-0.237740697253647,0.812082216622357]
["HistologyGlioblastoma",null,null,0]
["Histology (Oligoastrocytoma vs Glioblastoma)",-0.0012081147589057,0.998792614717936,0.560698834332331,-0.00215465894510785,0.998280832224125]
["Histology (Oligodendroglioma vs Glioblastoma)",-0.324997391656418,0.722529238244116,0.493039422606383,-0.65917120772689,0.509785833655034]
["IDH Mutation (No vs Yes)",0.400126215677175,1.49201300118889,0.266269626276255,1.50271069694612,0.132913663079324]
["Chr 1p/19q Co-deletion (Yes vs No)",-0.0280661337376906,0.97232406125047,0.328561583712216,-0.0854212273406662,0.931926517861527]
["Subtype (C2 vs C1)",0.93230291030865,2.54035265084521,0.331124006864259,2.81557027271309,0.00486907469608255]
[" "]
["TCGA-LGG"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",-0.867845275363028,0.419855247733552,0.214967471132945,-4.03710045426508,{"v":5.41159006881564e-05,"d":"5.41E-05"}]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",0.0613348982494137,1.06325493678521,0.0111597826843475,5.49606564789483,{"v":3.88357985769971e-08,"d":"3.88E-08"}]
["Gender (Male vs Female)",0.144550072550607,1.15551955332649,0.263947040871613,0.547648013303236,0.583933614718533]
["Grade (III vs II)",0.998021818579734,2.71290988893821,0.310627119087008,3.21292558587,0.00131390326965353]
["Histology (Oligoastrocytoma vs Glioblastoma)",0.39697138968244,1.48731337693456,0.340979099700966,1.1642103285233,0.244338785568878]
["Histology (Oligodendroglioma vs Glioblastoma)",-0.132848738960404,0.875597525884516,0.346252998612011,-0.383675345752791,0.701219087903755]
["IDH Mutation (No vs Yes)",1.17498407165991,3.23809136600667,0.423896939232504,2.77186259893101,0.00557365576198221]
["Chr.1p.19q.No co-deletion",0.659860907720296,1.9345232384405,0.560525002826392,1.1772194003711,0.239107947216697]
["MGMTmethyUnmethylation",-0.232227201098731,0.792765985540758,0.395913022084279,-0.586561159004505,0.557498475146629]
["SurgerySubtotal Resection",0.221543097994503,1.24800103340342,0.280843081670629,0.788850117569668,0.430199613318781]
["Subtype (C2 vs C1)",0.203010189097169,1.22508495069351,0.48657353086783,0.417224070399163,0.676514520626375]
[" "]
["GSE108474"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",-0.902889559716808,0.405396548134004,0.107302559757914,-8.41442703467484,0]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age (50-89 vs 15-49)",0.709184937346625,2.0323341037688,0.16425760096633,4.31751671261773,{"v":1.57794464179517e-05,"d":"1.58E-05"}]
["Gender (Male vs Female)",0.24943501081344,1.28330016111212,0.157505159531564,1.58366247528199,0.113270548445759]
["Grade (III vs II)",0.180039432469339,1.19726457328957,0.205941708818823,0.874225204316086,0.381995622674458]
["Grade (IV vs II)",0.479402108524835,1.6151084538795,0.317379025890089,1.51050343412061,0.130915013776254]
["Histology (Astrocytoma vs Glioblastoma)",0.0315701877918749,1.03207381203546,0.243729899042443,0.129529400848672,0.896938762393023]
["Histology (Oligoastrocytoma vs Glioblastoma)",-0.254931797626188,0.774969350908076,0.496804315214951,-0.513143283620408,0.607851096117612]
["Histology (Oligodendroglioma vs Glioblastoma)",null,null,0]
["Subtype (C2 vs C1)",-0.610718239630398,0.54296075306228,0.200255416250416,-3.04969648794271,0.0022907273502133]
[" "]
["E-MTAB-3892"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",0.0967857468395143,1.10162432184187,0.317308662445881,0.305020815043213,0.760350299158399]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",0.0394641772855157,1.04025323352291,0.0154519789307285,2.55398855139747,0.0106496758131247]
["Gender (Male vs Female)",-0.118916666149016,0.887881788287711,0.334241329762763,-0.355780855208483,0.72200468755074]
["Grade (III vs II)",0.192926764601122,1.21279397081647,0.476267976138498,0.405080278891183,0.685418502144375]
["Grade (IV vs II)",2.38821816151654,10.8940651741498,1.09593553204289,2.17915934987961,0.0293198325581949]
["Histology (Astrocytoma vs Glioblastoma)",0.886206086584678,2.42590848345459,1.57522324276616,0.562590788737006,0.573713565808309]
["Histology (Oligoastrocytoma vs Glioblastoma)",0.724670652290615,2.06405119747653,0.836469682850873,0.866344192918957,0.386301438113636]
["Histology (Oligodendroglioma vs Glioblastoma)",2.0676404636953,7.90614625303007,1.10255925244504,1.8753100652959,0.0607500794545156]
["IDH Mutation (No vs Yes)",0.755103880373531,2.12783255191514,0.485256146619326,1.55609338621298,0.119685887495794]
["Chr.1p.19q.No co-deletion",1.39646293666925,4.04088180479371,0.511354051063985,2.73091204374659,0.0063159325389105]
["Subtype (C2 vs C1)",-0.0915031387184187,0.912558451883495,0.417210145666013,-0.219321461064538,0.826399645332166]
[" "]
["GSE85217"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",0.508905504290779,1.66346953795814,0.175250058181508,2.90388208467069,0.0036856694261882]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",-0.00831240867808863,0.991722043863635,0.00965263934320707,-0.861153968622933,0.389153248563787]
["Gender (Male vs Female)",0.0642611702235932,1.06637086671385,0.172944978189064,0.371570027048386,0.710213008717715]
["SubgroupGroup4",-0.602927687229026,0.547207237011235,0.19001515010871,-3.17305060614422,0.00150846228711388]
["SubgroupSHH",-1.01654278828868,0.361843750680595,0.489654446427061,-2.07604116679885,0.0378901437329531]
["SubgroupWNT",-2.64748739792219,0.0708289546485978,0.738363750837207,-3.58561399434938,0.000336286066347946]
["Subtype (C2 vs C1)",-0.349167600345243,0.705274916044438,0.45980988965057,-0.759373837327837,0.447628959411502]
[" "]
["TCGA-GBM"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",-0.227685445545483,0.796374723657924,0.174423530507054,-1.30535968904881,0.191770397964381]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",0.00411601895335005,1.00412450139333,0.0119305584242573,0.344998013251528,0.73009586434138]
["Gender (Male vs Female)",0.46623641583298,1.59398379781348,0.288561106825122,1.61572854000569,0.106153017600162]
["IDH Mutation (No vs Yes)",1.01809727873032,2.76792316408496,0.676258200076812,1.50548603863832,0.132199163610887]
["Therapy (Radiotherapy vs Chemo-radio therapy)",-0.709643340860289,0.491819578131176,0.264028995242721,-2.6877477612181,0.00719357136398002]
["MGMT methylation (Yes vs No)",-0.300768764663509,0.740248924666942,0.284207248648979,-1.05827267282329,0.28993114774519]
["Subtype (C2 vs C1)",-0.0228970357338875,0.977363112068188,0.275976699132101,-0.082967278780762,0.933877557632663]
[" "]
["GSE13041"]
["Univariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Subtype (C2 vs C1)",0.19799054555529,1.21895086926357,0.128656074158892,1.53891331481768,0.123825460164125]
["Multivariate Cox model"]
[null,"Coef","exp(Coef)","se(Coef)","Z-score","Pr(>|z|)"]
["Age",0.0236718844343751,1.02395428742503,0.00525824143353133,4.50186335747568,{"v":6.73602847744981e-06,"d":"6.74E-06"}]
["Gender (Male vs Female)",0.12071379562054,1.12830194119474,0.139771113306004,0.863653388495646,0.387778326316232]
["Subtype (C2 vs C1)",-0.000583628557947814,0.999416541720071,0.138613408357977,-0.00421047692904686,0.996640535390863]
[" "]