{"text_format":"3","workbook":"xlsx","n_sheets":1,"sheets":["add5"],"read":"whole","date_system":"1900"}

{"sheet":"add5","index":0,"n_rows":72,"n_cols":7,"rows_kept":72,"merged":[[3,2,3,5],[3,9,3,12],[21,2,21,6],[53,0,54,3],[69,5,69,8],[71,0,72,3]]}
["Linear regression for alpha diversity, inflammatory markers/SCFAs and PD status"]
[]
["A. Model: log(variable) ~ sex + PD/control + Diversity"]
[null,null,"p-value"]
["Variable","Diversity index","Entire model","Sex","PD/control","Diversity"]
["Total_SCFAs","Shannon",{"v":0.010103035,"d":"0.010"},{"v":0.31126289,"d":"0.311"},{"v":0.024997384,"d":"0.025"},{"v":0.008885321,"d":"0.009"}]
["Total_SCFAs","InvSimpson",{"v":0.036232952,"d":"0.036"},{"v":0.348634292,"d":"0.349"},{"v":0.041422653,"d":"0.041"},{"v":0.043413706,"d":"0.043"}]
["Propionic acid","Shannon",{"v":0.00568607,"d":"0.006"},{"v":0.597739317,"d":"0.598"},{"v":0.019575299,"d":"0.020"},{"v":3.932049E-3,"d":"0.004"}]
["Propionic acid","InvSimpson",{"v":0.045154553,"d":"0.045"},{"v":0.662526888,"d":"0.663"},{"v":0.036507305,"d":"0.037"},{"v":0.050148278,"d":"0.050"}]
["Butyric acid","Shannon",{"v":0.000218193,"d":"0.000"},{"v":0.256272516,"d":"0.256"},{"v":2.48185E-4,"d":"0.000"},{"v":0.005762172,"d":"0.006"}]
["Butyric acid","InvSimpson",{"v":0.000588042,"d":"0.001"},{"v":0.285517537,"d":"0.286"},{"v":5.30497E-4,"d":"0.001"},{"v":0.018407789,"d":"0.018"}]
["Stool NGAL","Shannon",{"v":4.76e-05,"d":"0.000"},{"v":0.994710568,"d":"0.995"},{"v":0.365366684,"d":"0.365"},{"v":3.7e-06,"d":"0.000"}]
["Stool NGAL","InvSimpson",{"v":0.001694829,"d":"0.002"},{"v":0.879153194,"d":"0.879"},{"v":0.255864997,"d":"0.256"},{"v":0.00018539,"d":"0.000"}]
["Stool calprotectin","Shannon",{"v":1.09e-05,"d":"0.000"},{"v":0.020777283,"d":"0.021"},{"v":0.061995817,"d":"0.062"},{"v":3.37e-05,"d":"0.000"}]
["Stool calprotectin","InvSimpson",{"v":1.09e-05,"d":"0.000"},{"v":0.023177107,"d":"0.023"},{"v":0.032692084,"d":"0.033"},{"v":3.36e-05,"d":"0.000"}]
["Stool zonulin","Shannon",{"v":0.010380898,"d":"0.010"},{"v":0.883432822,"d":"0.883"},{"v":0.823040331,"d":"0.823"},{"v":0.000997464,"d":"0.001"}]
["Stool zonulin","InvSimpson",{"v":0.046222755,"d":"0.046"},{"v":0.82953642,"d":"0.830"},{"v":0.649966482,"d":"0.650"},{"v":5.874799E-3,"d":"0.006"}]
["Stool IL1b","Shannon",{"v":0.407131214,"d":"0.407"},{"v":0.129875861,"d":"0.130"},{"v":0.481350372,"d":"0.481"},{"v":0.564233604,"d":"0.564"}]
["Stool IL1b","InvSimpson",{"v":0.258419072,"d":"0.258"},{"v":0.125074757,"d":"0.125"},{"v":0.499982312,"d":"0.500"},{"v":0.228673593,"d":"0.229"}]
[]
["B. Model: log(variable) ~ sex + PD/control * Diversity"]
[null,null,"p-value"]
["Variable","Diversity index","Entire model","Sex","PD/control","Diversity","Interaction: PD/control and diversity"]
["Total_SCFAs","Shannon",{"v":0.00406564,"d":"0.004"},{"v":0.346183473,"d":"0.346"},{"v":0.029075658,"d":"0.029"},{"v":1.151418E-3,"d":"0.001"},{"v":0.045401123,"d":"0.045"}]
["Total_SCFAs","InvSimpson",{"v":0.016111248,"d":"0.016"},{"v":0.390561082,"d":"0.391"},{"v":0.01374632,"d":"0.014"},{"v":0.005996685,"d":"0.006"},{"v":0.056688321,"d":"0.057"}]
["Propionic acid","Shannon",{"v":0.001223489,"d":"0.001"},{"v":0.660337898,"d":"0.660"},{"v":0.011729135,"d":"0.012"},{"v":0.000240441,"d":"0.000"},{"v":0.01967405,"d":"0.020"}]
["Propionic acid","InvSimpson",{"v":0.007892287,"d":"0.008"},{"v":0.739558686,"d":"0.740"},{"v":0.003273759,"d":"0.003"},{"v":0.002015147,"d":"0.002"},{"v":0.016626198,"d":"0.017"}]
["Butyric acid","Shannon",{"v":0.000180987,"d":"0.000"},{"v":0.282886683,"d":"0.283"},{"v":0.047326077,"d":"0.047"},{"v":0.0018072,"d":"0.002"},{"v":0.094081272,"d":"0.094"}]
["Butyric acid","InvSimpson",{"v":0.000630457,"d":"0.001"},{"v":0.315264989,"d":"0.315"},{"v":0.011422172,"d":"0.011"},{"v":0.008666416,"d":"0.009"},{"v":0.142411471,"d":"0.142"}]
["Stool NGAL","Shannon",{"v":3.65E-5,"d":"0.000"},{"v":0.908507941,"d":"0.909"},{"v":0.092473195,"d":"0.092"},{"v":4.62e-06,"d":"0.000"},{"v":0.078059402,"d":"0.078"}]
["Stool NGAL","InvSimpson",{"v":0.000863261,"d":"0.001"},{"v":0.802288319,"d":"0.802"},{"v":0.147939212,"d":"0.148"},{"v":1.01914E-4,"d":"0.000"},{"v":0.055500685,"d":"0.056"}]
["Stool calprotectin","Shannon",{"v":2.95e-05,"d":"0.000"},{"v":0.019610261,"d":"0.020"},{"v":0.370787844,"d":"0.371"},{"v":0.01325071,"d":"0.013"},{"v":0.459994069,"d":"0.460"}]
["Stool calprotectin","InvSimpson",{"v":3.81e-05,"d":"0.000"},{"v":0.023990018,"d":"0.024"},{"v":0.490544818,"d":"0.491"},{"v":0.006798303,"d":"0.007"},{"v":0.987454545,"d":"0.987"}]
["Stool zonulin","Shannon",{"v":0.023944027,"d":"0.024"},{"v":0.890200359,"d":"0.890"},{"v":0.839024448,"d":"0.839"},{"v":0.027018853,"d":"0.027"},{"v":0.853239792,"d":"0.853"}]
["Stool zonulin","InvSimpson",{"v":0.077626424,"d":"0.078"},{"v":0.854809255,"d":"0.855"},{"v":0.433162915,"d":"0.433"},{"v":0.206211242,"d":"0.206"},{"v":0.500969821,"d":"0.501"}]
["Stool IL1b","Shannon",{"v":0.558469546,"d":"0.558"},{"v":0.129564931,"d":"0.130"},{"v":0.78862649,"d":"0.789"},{"v":0.855161946,"d":"0.855"},{"v":0.743129288,"d":"0.743"}]
["Stool IL1b","InvSimpson",{"v":0.386457917,"d":"0.386"},{"v":0.130076523,"d":"0.130"},{"v":0.570292153,"d":"0.570"},{"v":0.291040571,"d":"0.291"},{"v":0.712189711,"d":"0.712"}]
[]
["C. Stool calprotectin and additional confounders (selected based on Fig 3C)"]
["","Simple model","All confounders","Main confounders"]
["Sex","-1.461 ** (0.546)","-1.171 * (0.520)","-1.316 * (0.521)"]
["PD vs control","0.381 * (0.179)","0.007 (0.214)","0.211 (0.177)"]
["Inverse Simpson index","-0.095 *** (0.016)","-0.084 *** (0.016)","-0.091 *** (0.015)"]
["Diabetes","      ","0.561 * (0.274)","0.596 * (0.277)"]
["Relative with PD","      ","0.519 * (0.239)","0.461 · (0.238)"]
["RBDSQ score","      ","0.051 (0.037)","      "]
["BPS stool consistency","      ","-0.161 * (0.078)","-0.181 * (0.077)"]
["BPS defecation frequency","      ","-0.138 (0.104)","      "]
["Sex and inverse Simpson interaction ","0.093 *** (0.025)","0.078 ** (0.024)","0.087 *** (0.024)"]
["N",109,109,109]
["R2",0.307,0.418,0.393]
["logLik",-144.517,-134.94,-137.258]
["AIC",301.033,291.88,292.517]
["*** p < 0.001; ** p < 0.01; * p < 0.05; · p < 0.1\nResults given as: Estimate / p-value stars / (Std. Error)"]
[]
[]
["D. Propionic acid and additional confounders (selected based on Fig 3A)"]
[null,"Simple model","All confounders","Main confounders"]
["Sex","0.048 (0.109)","-0.025 (0.111)"]
["PD vs control","-3.313 * (1.292)","-2.793 * (1.299)","-3.332 ** (1.266)"]
["Shannon index","-0.925 *** (0.243)","-0.854 *** (0.238)","-0.898 *** (0.239)"]
["GDS15 score",null,"-0.029 (0.023)"]
["ACE-AT1 medication",null,"0.165 (0.116)"]
["Statin medication",null,"0.163 (0.128)"]
["NMSS total score",null,"0.002 (0.003)"]
["Rome III 9-15 sum score",null,"-0.031 * (0.014)","-0.026 * (0.013)"]
["PD/C and Shannon interaction","0.812 * (0.343)","0.736 * (0.348)","0.853 * (0.336)"]
["N",110,110,110]
["R2",0.156,0.237,0.188]
["logLik",-91.635,-86.098,-89.501]
["AIC",195.271,194.196,191.003]
["*** p < 0.001; ** p < 0.01; * p < 0.05; · p < 0.1\nResults given as: Estimate / p-value stars / (Std. Error)"]