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{"sheet":"summary_table","index":0,"n_rows":16,"n_cols":9,"rows_kept":16,"merged":[[14,0,14,8],[15,0,17,8]]}
["Variable","Different in PD vs controls","Alpha diversity correlation","Beta diversity association","Different between enterotypes","Correlated clinical variables","Inversely correlated clinical variables","Correlated bacterial genera","Inversely correlated bacterial genera"]
["Total SCFAs","no","yes; - (A, C)","yes (A, C)","no","BPS consistency (C), Other GIT surgery (A, P), Diuretics (P), Statins (A, P), Age motor onset (P)","GDS15 (A), NMSS (A, C), Rome III: 9-15 (A, C)","not tested","not tested"]
["Acetic acid","no","yes; - (C)","yes (A, C)","no","BPS consistency (A, C), BPS frequency (P), Hypertension (P), Other GIT surgery (A, P), Beta blockers (P), Diuretics (P), Statins (A, P)","GDS15 (A), NMSS (A, C), Rome III: 9-15 (A, C), Wexner (C)","Bacteroides (C), Butyricicoccus (A, C), Clostridium sensu stricto (A, P), Romboutsia (A, C, P), Roseburia (A, C)","Akkermansia (A, C, P), Anaerotruncus (A, C), Escherichia/Shigella (A, C), Flavonifractor (A, P), Intestinimonas (C), Phascolarctobacterium (C), Sporobacter (C)"]
["Propionic acid","PD: - (A)","yes; - (A, C)","yes (A, C)","yes (A)","Diabetes (P), ACE-AT1 (A), Diuretics (P), Statins (A)","GDS15 (A), NMSS (A, C), Rome III: 9-15 (A)","Butyricicoccus (A, C, P), Romboutsia (A, C, P), Roseburia (A, C, P)","Anaerotruncus (A, C)"]
["Butyric acid","PD: - (A, M)","yes; - (A, C)","yes (A, C, P)","yes (A, P)","Age at sampling (P), BPS consistency (A, C), Other GIT surgery (P), Statins (A, P), Warfarin (P), Age motor onset (P), Age NMS onset (P)","GDS15 (A), NMSQuest (A), NMSS (A), Rome III: 9-15 (A, C), SDQ (A)","Butyricicoccus (A*), Romboutsia (A, C, P), Roseburia (A, C, P)","Akkermansia (A, C), Alistipes (A*), Anaerotruncus (A, C, P), Bifidobacterium (A*, P), Escherichia/Shigella (A, C), Flavonifractor (A*, P), Intestinimonas (A), Phascolarctobacterium (C), Sporobacter (A*, C)"]
["Stool NGAL","no","yes; - (A, C)","yes (A, C)","yes (A, C)","none","none","Bacteroides (A, C), Bifidobacterium (A*, P), Roseburia (C)","Akkermansia (P), Anaerotruncus (A, C), Flavonifractor (P), Intestinimonas (P), Prevotella (C), Sporobacter (A)"]
["Stool calprotectin","PD: + (A, F)","yes; - (A, P)","no","no","Diabetes (A, P), Statins (C), PD relative (A), RBDSQ (A)","BPS consistency (A), BPS frequency (A), Rome III: IBS+ (P)","Streptococcus (A, P), Veillonella (A)","none"]
["Stool zonulin","no","yes; - (A, C)","yes (A, C, P)","yes (C)","ENT surgery (P), Beta blockers (C), Warfarin (C), SDQ (C)","GDS15 (P), NMSQuest (P), NMSS (P), SDQ (P), Akinetic rigid score Poletti (P), Hoehn and Yahr (P), PIGD score Jankovic (P), UPDRS I (P), UPDRS II (P), UPDRS III (P), UPDRS IV (P)","Anaerotruncus (C), Flavonifractor (C)","Coprococcus (A, C, P), Prevotella (C), Victivallis (C)"]
["Stool CXCL8","no","yes; - (P)","no","no","ACE AT1 (C), PD relative (A, P), Ropinirole (mg) (P)","BPS consistency (A, P), BPS frequency (C), Age motor onset (P)","not tested","not tested"]
["Stool IL1b","no","yes; - (A)","no","no","ASA (C), PD relative (A, P), Ropinirole (mg) (P)","BMI (A, P), BPS consistency (A), Age motor onset (P)","not tested","not tested"]
["Stool IL2","no","no","yes (A)","no","PD relative (C), Levodopa IR (mg) (P)","BPS consistency (C)","not tested","not tested"]
["Stool PC","no","no","yes (A)","no","BPS consistency (C)","PD relative (A, C), Levodopa IR (mg) (P)","not tested","not tested"]
["Plasma CXCL8","PD: - (A, F)","no","no","no","BMI (P), TIA/stroke (A), Diuretics (A, P), Tremor by AR Poletti (P)","Hypercholesterolemia (C), NMSQuest (A), NMSS (A), RLS (A), Rome III: 9-15 (A, C), Rome III: IBS+ (A)","not tested","not tested"]
[]
["Abbreviations for subsets: A: all samples, M: only males, F: only females, C: only control subjects, P: only PD patients, \nA*: all samples without confounder correction in differential abundance comparisons"]
["Abbreviations for clinical variables: BPS: Bowel Performance Scale, GIT: gastrointestinal tract, NMS: Non-Motor Symptoms, ENT: Ear, Nose and Throat, RBDSQ: REM Sleep Behavior Disorder Screening Questionnaire, SDQ: Swallowing Disturbance Questionnaire, ASA: acetylsalicylic acid, BMI: body mass index, AR: akinetic-rigid, GDS: Geriatric Depression Scale, NMSS: non-motor symptoms scale, Rome III: IBS+: fulfilling Rome III IBS criteria, RLS: Restless Legs Syndrome"]