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{"sheet":"Supplementary Tables S2","index":0,"n_rows":55,"n_cols":22,"rows_kept":55,"merged":[[0,0,0,7]]}
["PPIN construction and enrichment analysis"]
["AverageShortestPathLength","BetweennessCentrality","ClosenessCentrality","ClusteringCoefficient","Degree","degree.layout","diffusion_input","diffusion_output_heat","diffusion_output_rank","Eccentricity","EdgeCount","Indegree","IsSingleNode","name","NeighborhoodConnectivity","NumberOfUndirectedEdges","Outdegree","Radiality","selected","shared name","Stress","TopologicalCoefficient"]
[1,0,1,0.5,16,16,0,0.013548483,52,1,16,0,false,"TMED5",50.875,16,16,0.986686391,false,"TMED5",0,0.978365385]
[1.533333333,{"v":0.000448,"d":"4.48E-04"},0.652173913,0.494071146,23,23,0,0.015633125,51,2,23,9,false,"LRP5L",49.65217391,23,14,0.989275148,false,"LRP5L",19,0.954849498]
[1.193548387,0,0.837837838,0.494652406,34,34,0,0.017494797,48,2,34,9,false,"GPC3",49.64705882,34,25,0.993343195,false,"GPC3",0,0.954751131]
[1.115384615,0.030836266,0.896551724,0.479487179,40,40,0,0.017851348,47,2,40,17,false,"MUSK",48.7,40,23,0.99556213,false,"MUSK",336,0.936538462]
[1.326530612,0,0.753846154,0.498106061,33,33,0,0.017393056,49,2,33,0,false,"CER1",49.75757576,33,33,0.992973373,false,"CER1",0,0.956876457]
[1,0.022521119,1,0.466530612,50,50,0,0.018988889,26,1,50,7,false,"FRZB",47.54,50,43,0.999260355,false,"FRZB",493,0.914230769]
[1,0.004441093,1,0.454117647,51,51,0,0.018852303,42,1,51,38,false,"WNT10B",46.90196078,51,13,0.999630178,false,"WNT10B",112,0.901960784]
[1,0.010549598,1,0.482269504,48,48,0,0.019152522,5,1,48,29,false,"SFRP4",48.375,48,19,0.99852071,false,"SFRP4",146,0.930288462]
[1,0.00979545,1,0.480053191,48,48,0,0.019142238,6,1,48,28,false,"SFRP2",48.25,48,20,0.99852071,false,"SFRP2",147,0.927884615]
[1,2.681414E-3,1,0.454117647,51,51,0,0.018852303,41,1,51,42,false,"WNT2B",46.90196078,51,9,0.999630178,false,"WNT2B",84,0.901960784]
[1,0.001110273,1,0.476615646,49,49,0,0.019090209,11,1,49,33,false,"WIF1",48.06122449,49,16,0.998890533,false,"WIF1",39,0.924254317]
[1,0.004441093,1,0.454117647,51,51,0,0.018852303,40,1,51,39,false,"WNT11",46.90196078,51,12,0.999630178,false,"WNT11",112,0.901960784]
[1,0,1,0.463673469,50,50,0,0.018948036,30,1,50,43,false,"WNT5B",47.4,50,7,0.999260355,false,"WNT5B",0,0.911538462]
[1,0,1,0.463673469,50,50,0,0.018948036,29,1,50,36,false,"WNT10A",47.4,50,14,0.999260355,false,"WNT10A",0,0.911538462]
[1.042553191,0.020451701,0.959183673,0.474734043,48,48,0,0.019098029,10,2,48,3,false,"DKK2",48.02083333,48,45,0.99852071,false,"DKK2",353,0.923477564]
[1.076923077,0,0.928571429,0.493128964,44,44,0,0.019294617,1,2,44,20,false,"NKD2",49.09090909,44,24,0.99704142,false,"NKD2",0,0.944055944]
[1,0.001508296,1,0.454117647,51,51,0,0.018852303,39,1,51,49,false,"WNT8B",46.90196078,51,2,0.999630178,false,"WNT8B",56,0.901960784]
[1,0.001508296,1,0.454117647,51,51,0,0.018852303,38,1,51,48,false,"WNT8A",46.90196078,51,3,0.999630178,false,"WNT8A",56,0.901960784]
[1,{"v":0.000587,"d":"5.87E-04"},1,0.485990338,46,46,0,0.01921708,3,1,46,28,false,"SFRP5",48.60869565,46,18,0.997781065,false,"SFRP5",14,0.934782609]
[1,0.037162728,1,0.488436633,47,47,0,0.019221289,2,1,47,23,false,"PORCN",48.72340426,47,24,0.998150888,false,"PORCN",150,0.936988543]
[1,0,1,0.470301418,48,48,0,0.019000498,21,1,48,33,false,"WLS",47.8125,48,15,0.99852071,false,"WLS",0,0.919471154]
[1.04,0.013593123,0.961538462,0.478280142,48,48,0,0.019090207,12,2,48,24,false,"NOTUM",48.14583333,48,24,0.99852071,false,"NOTUM",245,0.92588141]
[1,0.001508296,1,0.454117647,51,51,0,0.018852303,37,1,51,45,false,"WNT6",46.90196078,51,6,0.999630178,false,"WNT6",56,0.901960784]
[1,0.006064605,1,0.484615385,40,40,0,0.019195336,4,1,40,8,false,"FZD10",48.7,40,32,0.99556213,false,"FZD10",140,0.936538462]
[1,0,1,0.463673469,50,50,0,0.018948036,28,1,50,39,false,"WNT16",47.4,50,11,0.999260355,false,"WNT16",0,0.911538462]
[1.043478261,0.020451701,0.958333333,0.474734043,48,48,0,0.019098029,9,2,48,4,false,"DKK4",48.02083333,48,44,0.99852071,false,"DKK4",353,0.923477564]
[1,0.05600508,1,0.460408163,50,50,0,0.018898031,33,1,50,12,false,"FZD4",47.24,50,38,0.999260355,false,"FZD4",1241,0.908461538]
[1,0.042623515,1,0.463265306,50,50,0,0.018962028,27,1,50,28,false,"RYK",47.38,50,22,0.999260355,false,"RYK",849,0.911153846]
[1.022222222,0.020320042,0.97826087,0.468537415,49,49,0,0.019019473,18,2,49,5,false,"DVL1",47.67346939,49,44,0.998890533,false,"DVL1",655,0.916797488]
[1,0.035438162,1,0.471717172,45,45,0,0.019063264,13,1,45,22,false,"ROR2",48.02222222,45,23,0.997411243,false,"ROR2",756,0.923504274]
[1,0.063393933,1,0.470238095,49,49,0,0.018997,23,1,49,16,false,"FZD8",47.75510204,49,33,0.998890533,false,"FZD8",1171,0.918367347]
[1,0.066853811,1,0.457647059,51,51,0,0.01890529,32,1,51,3,false,"DKK1",47.07843137,51,48,0.999630178,false,"DKK1",1129,0.905354449]
[1,0.006785474,1,0.473214286,49,49,0,0.019062808,15,1,49,32,false,"VANGL2",47.89795918,49,17,0.998890533,false,"VANGL2",344,0.9211146]
[1.027027027,0.041173507,0.973684211,0.470238095,49,49,0,0.018997,22,2,49,13,false,"FZD5",47.75510204,49,36,0.998890533,false,"FZD5",1110,0.918367347]
[1.027777778,0.05409958,0.972972973,0.471631206,48,48,0,0.019015313,19,2,48,13,false,"FZD6",47.85416667,48,35,0.99852071,false,"FZD6",833,0.920272436]
[1,0.01717769,1,0.474630021,44,44,0,0.019061405,16,1,44,13,false,"FZD9",48.18181818,44,31,0.99704142,false,"FZD9",762,0.926573427]
[1,0.002491967,1,0.445701357,52,52,0,0.018773744,46,1,52,48,false,"WNT7B",46.46153846,52,4,1,false,"WNT7B",116,0.893491124]
[1.025,0.037528459,0.975609756,0.461309524,49,49,0,0.018893707,34,2,49,10,false,"FZD2",47.32653061,49,39,0.998890533,false,"FZD2",1083,0.910125589]
[1.022727273,0.020320042,0.977777778,0.468537415,49,49,0,0.019019473,17,2,49,6,false,"DVL3",47.67346939,49,43,0.998890533,false,"DVL3",655,0.916797488]
[1,0.042630179,1,0.467346939,50,50,0,0.019001965,20,1,50,20,false,"LRP5",47.58,50,30,0.999260355,false,"LRP5",924,0.915]
[0,0,0,0.454901961,51,51,0,0.018865138,35,0,51,51,false,"WNT9B",46.94117647,51,0,0.999630178,false,"WNT9B",0,0.902714932]
[1.047619048,0.021700402,0.954545455,0.474734043,48,48,0,0.019062833,14,2,48,8,false,"FZD1",48,48,40,0.99852071,false,"FZD1",740,0.923076923]
[1.029411765,0.037658639,0.971428571,0.471187943,48,48,0,0.01899513,25,2,48,15,false,"FZD7",47.85416667,48,33,0.99852071,false,"FZD7",1015,0.920272436]
[1,0.002491967,1,0.445701357,52,52,0,0.018773744,45,1,52,47,false,"WNT7A",46.46153846,52,5,1,false,"WNT7A",116,0.893491124]
[1,0,1,0.454901961,51,51,0,0.018865138,36,1,51,50,false,"WNT9A",46.94117647,51,1,0.999630178,false,"WNT9A",0,0.902714932]
[1.037037037,0.014122943,0.964285714,0.476873265,47,47,0,0.019112591,8,2,47,21,false,"NKD1",48.14893617,47,26,0.998150888,false,"NKD1",660,0.92594108]
[1,0.00530805,1,0.445701357,52,52,0,0.018773744,44,1,52,42,false,"WNT2",46.46153846,52,10,1,false,"WNT2",234,0.893491124]
[1,0.101621297,1,0.457647059,51,51,0,0.01890529,31,1,51,22,false,"LRP6",47.07843137,51,29,0.999630178,false,"LRP6",1372,0.905354449]
[1.076923077,0.011710188,0.928571429,0.483091787,46,46,0,0.019124962,7,2,46,10,false,"FZD3",48.52173913,46,36,0.997781065,false,"FZD3",562,0.933110368]
[1,0.00474244,1,0.445701357,52,52,0,0.018773744,43,1,52,44,false,"WNT3",46.46153846,52,8,1,false,"WNT3",204,0.893491124]
[1.047619048,0.013268435,0.954545455,0.467687075,49,49,0,0.01899606,24,2,49,29,false,"SFRP1",47.63265306,49,20,0.998890533,false,"SFRP1",507,0.916012559]
[1.489795918,0,0.671232877,0.491666667,25,25,0,0.016237548,50,2,25,0,false,"ADGRA2",49.24,25,25,0.990014793,false,"ADGRA2",0,0.946923077]
[{"$nulls":5},47,0,0,{"$nulls":5},"CCN4",{"$nulls":4},false,"CCN4"]

{"sheet":"Data Dictionary","index":1,"n_rows":23,"n_cols":2,"rows_kept":23}
["Variable","Description"]
["AverageShortestPathLength","Average length of the shortest paths between all pairs of nodes in the network. Measures network efficiency."]
["BetweennessCentrality","Number of shortest paths passing through a node. Identifies influential \"bridge\" nodes in the network."]
["ClosenessCentrality","Average inverse distance from a node to all other nodes. Measures how central a node is in the network."]
["ClusteringCoefficient","Likelihood that neighboring nodes are interconnected. Quantifies local \"cliquishness\" of a node."]
["Degree","Total number of edges (connections) a node has."]
["degree.layout","Layout algorithm parameter that scales node size/position based on degree (e.g., in visualization tools)."]
["diffusion_input","Input metric for diffusion-based algorithms (e.g., heat diffusion, information spread) across the network."]
["diffusion_output_heat","Output value from a diffusion process (e.g., \"heat\" propagated to a node)."]
["diffusion_output_rank","Rank of nodes based on diffusion output (e.g., prioritization of nodes after diffusion)."]
["Eccentricity","Maximum shortest path length from a node to any other node."]
["EdgeCount","Total number of edges in the network."]
["Indegree","Number of incoming edges to a node (in directed networks)."]
["IsSingleNode","Boolean indicating whether a node is isolated (no edges)."]
["name","Label or identifier of a node (e.g., gene name, protein ID)."]
["NeighborhoodConnectivity","Average degree of neighboring nodes. Measures local connectivity around a node."]
["NumberOfUndirectedEdges","Total edges in an undirected network (non-directional connections)."]
["Outdegree","Number of outgoing edges from a node (in directed networks)."]
["Radiality","Measure of how close a node is to all other nodes (related to closeness centrality)."]
["selected","Flag indicating whether a node/edge is selected (e.g., in visualization or analysis workflows)."]
["shared name","Default node/edge identifier in some tools (e.g., Cytoscape) if no custom \"name\" is provided."]
["Stress","Number of shortest paths passing through a node or edge. Similar to betweenness but counts all shortest paths."]
["TopologicalCoefficient","Measures how interconnected a node's neighbors are relative to all possible connections."]