{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":136,"n_cols":11,"rows_kept":136,"flags":["formulas_cached_only"]}
["说明：表中数据上面两列或一列有名称的为该组均数，下面两列为标准差，分别从上到下依次对应一列组别，数据均经过统计学处理，结果描述参看旁边描述"]
["Figure 1"]
[1,"adjacent normal","tumor",null,"adjacent normal","tumor"]
["SOX5 mRNA",0.89,4.5,"miR-219-5p",4.3,0.87,"与癌旁组织相比有统计学差异，P<0.05"]
["SOX5 protein",0.76,3.7,null,0.23,0.07]
[null,0.05,0.19]
[null,0.02,0.12]
[2,"SCC4","SCC9","normal HF"]
["SOX5 mRNA",4.1,3.6,0.78,null,null,"与正常人纤维细胞相比有统计学差异，P<0.05"]
["SOX5 protein",3.4,2.9,0.65]
["miR-219-5p",0.35,0.42,2.29]
[null,0.11,0.16,0.02]
[null,0.21,0.14,0.08]
[null,0.04,0.01,0.13]
[]
["Figure 2"]
["Relative luciferase activity"]
[null,"SOX5 3'UTR-wt+miR-NC","SOX5 3'UTR-wt+miR-219-5p","SOX5 3'UTR-mut+miR-NC","SOX5 3'UTR-mut+miR-219-5p"]
["SCC4",1.27,0.18,1.34,1.29,null,"与各自NC对照组相比有统计学差异，P<0.05"]
["SCC9",1.14,0.22,1.19,1.22]
[null,0.19,0.02,0.21,0.16]
[null,0.14,0.01,0.11,0.04]
["Relative expression of SOX5"]
["mRNA","miR-NC","miR-219-5p mimics","miR-219-5p inhibitor NC","miR-219-5p inhibitor"]
["SCC4",3.7,0.87,4.1,5.1,null,"与各自NC对照组相比有统计学差异，P<0.05"]
["SCC9",3.6,0.76,3.9,4.8]
[null,0.34,0.02,0.11,0.61]
[null,0.41,0.08,0.29,0.46]
["protein","miR-NC","miR-219-5p mimics","miR-219-5p inhibitor NC","miR-219-5p inhibitor"]
["SCC4",3.1,0.94,2.8,4.3,null,"与各自NC对照组相比有统计学差异，P<0.05"]
["SCC9",2.7,0.83,2.9,4.6]
[null,0.22,0.09,0.18,0.38]
[null,0.16,0.03,0.32,0.41]
[]
["Figure 3","possible role of sox5 in carcinogenetic events"]
["sox5 EXPRESSION","mRNA"]
[null,"pcDNA3.1","pcDNA3.1-SOX5",null,"siRNA-1","siRNA-2","siRNA-3","scramble siRNA control"]
["SCC4",3.8,5.5,"SCC4",0.98,2.5,1.9,3.9]
["SCC9",3.7,6.2,"SCC9",1.04,2.34,1.78,4.1]
[null,0.32,0.61,null,0.08,0.31,0.14,0.48]
[null,0.42,0.67,null,0.11,0.28,0.12,0.35]
[null,"与pcDNA3.1质粒空载对照组相比有统计学差异，P<0.05",{"$nulls":5},"与对照siRNA组相比有统计学差异，其中siRNA-1干扰片段效果最佳，后续实验选用此片段"]
[null,"protein"]
[null,"pcDNA3.1","pcDNA3.1-SOX5",null,"siRNA-1","siRNA-2","siRNA-3","scramble siRNA control"]
["SCC4",3.2,4.9,"SCC4",0.87,1.8,1.9,3.3]
["SCC9",2.8,4.5,"SCC9",0.93,1.6,2.1,3.1]
[null,0.27,0.43,null,0.08,0.34,0.15,0.44]
[null,0.33,0.51,null,0.11,0.27,0.19,0.31]
[null,"与pcDNA3.1质粒空载对照组相比有统计学差异，P<0.05",{"$nulls":5},"与对照siRNA组相比有统计学差异，其中siRNA-1干扰片段效果最佳，后续实验选用此片段"]
["A","colony number per well"]
[null,"pcDNA3.1","pcDNA3.1-SOX5","scramble siRNA control","siRNA-SOX5"]
["SCC4",126,309,119,61,null,"与各自对照组相比有统计学差异，P<0.05"]
["SCC9",114,299,124,67]
[null,7,23,8,9]
[null,9,19,12,10]
["B","CCK8(OD 490)"]
[null,"pcDNA3.1","pcDNA3.1-SOX5","scramble siRNA control","siRNA-SOX5"]
["SCC4",0.72,1.59,0.71,0.18,null,"与各自对照组相比有统计学差异，P<0.05"]
["SCC9",0.68,1.67,0.73,0.23]
[null,0.09,0.19,0.06,0.01]
[null,0.07,0.21,0.04,0.02]
["c","number of migrating cells"]
[null,"pcDNA3.1","pcDNA3.1-SOX5","scramble siRNA control","siRNA-SOX5"]
["SCC4",145,291,151,53,null,"与各自对照组相比有统计学差异，P<0.05"]
["SCC9",150,287,143,41]
[null,11,32,8,5]
[null,14,27,10,4]
["D","number of invading cells"]
[null,"pcDNA3.1","pcDNA3.1-SOX5","scramble siRNA control","siRNA-SOX5"]
["SCC4",112,197,109,41,null,"与各自对照组相比有统计学差异，P<0.05"]
["SCC9",108,210,111,32]
[null,12,19,8,7]
[null,10,24,11,5]
[]
[]
["Figure 4","possible role of miR-219-5p in carcinogenetic events"]
["MIR-219-5p EXPRESSION"]
[null,"miR-NC","miR-219-5p mimics","miR-219-5p inhibitor NC","miR-219-5p inhibitor"]
["SCC4",0.39,1.98,0.44,0.06]
["SCC9",0.41,2.09,0.37,0.08]
[null,0.04,0.09,0.01,0.01]
[null,0.03,0.11,0.02,0.01]
["A","colony number per well"]
[null,"miR-NC","miR-219-5p mimics","miR-219-5p inhibitor NC","miR-219-5p inhibitor"]
["SCC4",112,35,121,280,{"$nulls":4},"与各自NC对照组相比有统计学差异，P<0.05"]
["SCC9",102,29,109,310]
[null,8,2,7,21]
[null,10,3,11,19]
["B","CCK8(OD 490)"]
[null,"miR-NC","miR-219-5p mimics","miR-219-5p inhibitor NC","miR-219-5p inhibitor"]
["SCC4",0.69,0.21,0.76,1.43,null,"与各自NC对照组相比有统计学差异，P<0.05"]
["SCC9",0.72,0.18,0.67,1.39]
[null,0.03,0.02,0.04,0.17]
[null,0.09,0.01,0.03,0.11]
["c","number of migrating cells"]
[null,"miR-NC","miR-219-5p mimics","miR-219-5p inhibitor NC","miR-219-5p inhibitor"]
["SCC4",154,56,161,288,null,"与各自NC对照组相比有统计学差异，P<0.05"]
["SCC9",149,62,142,267]
[null,12,4,21,29]
[null,17,7,19,32]
["D","number of invading cells"]
[null,"miR-NC","miR-219-5p mimics","miR-219-5p inhibitor NC","miR-219-5p inhibitor"]
["SCC4",103,29,98,226,null,"与各自NC对照组相比有统计学差异，P<0.05"]
["SCC9",112,35,101,210]
[null,11,4,13,31]
[null,10,6,15,35]
[]
["Figure 5","miR-219-5p inhibits the tumor progress by targting SOX5"]
["A","colony number per well"]
[null,"miR-219-5p inhibitor","siRNA-SOX5","inhibitor+siRNA","Blank control",null,null,"miR-219-5p mimics","pcDNA3.1-SOX5","mimics+SOX5","Blank control"]
["SCC4",276,59,165,109,null,"SCC4",30,311,196,111]
["SCC9",282,63,177,116,null,"SCC9",33,305,185,108]
[null,43,5,33,7,null,null,5,39,30,15]
[null,39,3,26,9,null,null,7,45,28,11]
[null,"各组之间两两比较有统计学意义"]
["B","CCK8(OD 490)"]
[null,"miR-219-5p inhibitor","siRNA-SOX5","inhibitor+siRNA","Blank control",null,null,"miR-219-5p mimics","pcDNA3.1-SOX5","mimics+SOX5","Blank control"]
["SCC4",1.38,0.27,1.02,0.67,null,"SCC4",0.19,1.53,1.05,0.72]
["SCC9",1.42,0.24,0.98,0.71,null,"SCC9",0.22,1.62,1.1,0.69]
[null,0.12,0.01,0.09,0.06,null,null,0.03,0.14,0.15,0.06]
[null,0.23,0.02,0.05,0.04,null,null,0.02,0.21,0.11,0.09]
[null,"各组之间两两比较有统计学意义"]
["C","number of migrating cells"]
[null,"miR-219-5p inhibitor","siRNA-SOX5","inhibitor+siRNA","Blank control",null,null,"miR-219-5p mimics","pcDNA3.1-SOX5","mimics+SOX5","Blank control"]
["SCC4",279,58,198,148,null,"SCC4",61,290,121,153]
["SCC9",285,53,186,150,null,"SCC9",56,279,119,159]
[null,44,5,10,11,null,null,6,32,17,15]
[null,38,7,8,12,null,null,5,41,11,23]
[null,"各组之间两两比较有统计学意义"]
["D","number of invading cells"]
[null,"miR-219-5p inhibitor","siRNA-SOX5","inhibitor+siRNA","Blank control",null,null,"miR-219-5p mimics","pcDNA3.1-SOX5","mimics+SOX5","Blank control"]
["SCC4",218,43,129,102,null,"SCC4",31,201,95,105]
["SCC9",209,38,136,108,null,"SCC9",27,211,102,101]
[null,24,8,15,9,null,null,6,21,7,8]
[null,31,5,12,10,null,null,8,19,5,10]
[null,"各组之间两两比较有统计学意义",{"$nulls":5},"除了mimics+SOX5与Blank control相比无统计学差异，其他各组之间相比均有统计学差异"]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}