{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["Cluster 1 (Red)","Cluster 2 (Aquamarine)","Cluster 3 (Sky Blue)","Cluster 4 (Cornflower Blue)"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Cluster 1 (Red)","index":0,"n_rows":50,"n_cols":4,"rows_kept":50,"merged":[[0,0,0,3]],"flags":["formulas_cached_only"]}
["Suppl. Table- 4                             STRING PPI Network for WT-C vs. WT-D \n                                      Cluster 1 (Red)"]
["KEGG Pathway","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["Cell cycle",16,{"v":2.6e-18,"d":"2.60E-18"},"Cdc20,Cdk1,Mcm4,Pkmyt1,Mcm6,Bub1,Ccnb2,Bub1b,Mcm3,Espl1,Ttk,Ccnb1,Cdc26,Cdc6,E2f1,Mcm5"]
["Oocyte meiosis",9,{"v":1.55e-08,"d":"1.55E-08"},"Cdc20,Cdk1,Pkmyt1,Sgol1,Bub1,Ccnb2,Espl1,Ccnb1,Cdc26"]
["DNA replication",6,{"v":1.37e-07,"d":"1.37E-07"},"Pole,Mcm4,Mcm6,Mcm3,Pole4,Mcm5"]
["Progesterone-mediated oocyte maturation",6,{"v":1.81e-05,"d":"1.81E-05"},"Cdk1,Pkmyt1,Bub1,Ccnb2,Ccnb1,Cdc26"]
["p53 signaling pathway",5,{"v":6.37e-05,"d":"6.37E-05"},"Cdk1,Ccng1,Ccnb2,Ccnb1,Gtse1"]
["HTLV-I infection",7,0.00059,"Cdc20,Pole,Ccnb2,Bub1b,Cdc26,Pole4,E2f1"]
["MicroRNAs in cancer",4,0.0134,"Brca1,Ccng1,Cdca5,E2f1"]
["Platinum drug resistance",3,0.0195,"Brca1,Top2a,Birc5"]
["Cellular senescence",4,0.0222,"Cdk1,Ccnb2,Ccnb1,E2f1"]
["Base excision repair",2,0.0371,"Pole,Pole4"]
["Homologous recombination",2,0.0459,"Brca1,Rad51"]
[]
["Reactome Pathway","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["Cell Cycle",34,1.35e-31,"Cdc20,Pole,Brca1,Cdk1,Hmmr,Aurkb,Esco2,Mcm4,Pkmyt1,Sgol1,Ndc80,Incenp,Cdca5,Mcm6,Ccnb2,Bub1b,Clspn,Mcm3,Kif2c,Espl1,Ccnb1,Birc5,Cenpi,Cdc26,Cdc6,Pole4,E2f1,Ncaph,Nuf2,Ncapg,Gtse1,Tpx2,Cenpf,Kif20a"]
["Cell Cycle, Mitotic",32,1.06e-30,"Cdc20,Pole,Cdk1,Hmmr,Aurkb,Esco2,Mcm4,Pkmyt1,Sgol1,Ndc80,Incenp,Cdca5,Mcm6,Ccnb2,Bub1b,Mcm3,Kif2c,Espl1,Ccnb1,Birc5,Cenpi,Cdc26,Cdc6,Pole4,E2f1,Ncaph,Nuf2,Ncapg,Gtse1,Tpx2,Cenpf,Kif20a"]
["Cell Cycle Checkpoints",23,6.32e-24,"Cdc20,Brca1,Cdk1,Aurkb,Mcm4,Pkmyt1,Sgol1,Ndc80,Incenp,Mcm6,Ccnb2,Bub1b,Clspn,Mcm3,Kif2c,Ccnb1,Birc5,Cenpi,Cdc26,Cdc6,Nuf2,Gtse1,Cenpf"]
["Resolution of Sister Chromatid Cohesion",15,2.25e-17,"Cdc20,Cdk1,Aurkb,Sgol1,Ndc80,Incenp,Cdca5,Ccnb2,Bub1b,Kif2c,Ccnb1,Birc5,Cenpi,Nuf2,Cenpf"]
["Mitotic Prometaphase",17,2.25e-17,"Cdc20,Cdk1,Aurkb,Sgol1,Ndc80,Incenp,Cdca5,Ccnb2,Bub1b,Kif2c,Ccnb1,Birc5,Cenpi,Ncaph,Nuf2,Ncapg,Cenpf"]
["M Phase",20,2.25e-17,"Cdc20,Cdk1,Aurkb,Sgol1,Ndc80,Incenp,Cdca5,Ccnb2,Bub1b,Kif2c,Espl1,Ccnb1,Birc5,Cenpi,Cdc26,Ncaph,Nuf2,Ncapg,Cenpf,Kif20a"]
["Separation of Sister Chromatids",14,1.24e-13,"Cdc20,Aurkb,Sgol1,Ndc80,Incenp,Cdca5,Bub1b,Kif2c,Espl1,Birc5,Cenpi,Cdc26,Nuf2,Cenpf"]
["Mitotic Spindle Checkpoint",12,1.66e-13,"Cdc20,Aurkb,Sgol1,Ndc80,Incenp,Bub1b,Kif2c,Birc5,Cenpi,Cdc26,Nuf2,Cenpf"]
["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal",11,1e-12,"Cdc20,Aurkb,Sgol1,Ndc80,Incenp,Bub1b,Kif2c,Birc5,Cenpi,Nuf2,Cenpf"]
["RHO GTPases Activate Formins",12,1.34e-12,"Cdc20,Aurkb,Diap3,Sgol1,Ndc80,Incenp,Bub1b,Kif2c,Birc5,Cenpi,Nuf2,Cenpf"]
[]
["Biological Processes","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["cell cycle",62,3.44e-60,"Uhrf1,Cdc20,Pole,Brca1,Cdk1,Ccng1,Fam64a,Aurkb,Kif18b,Plk2,Ska3,Pbk,Esco2,Mcm4,Pkmyt1,Sgol1,Ndc80,Incenp,Cdca5,Mcm6,Rad51,Bub1,Cdk14,Ddias,Mki67,Ccnb2,Bub1b,Paf,Ckap2,Dlgap5,Ncapd2,Melk,Clspn,Anln,Kif4,E2f8,Timeless,Aspm,Mcm3,Kif2c,Espl1,Ttk,Top2a,Ccnb1,Nsl1,Birc5,Cdc26,Cdc6,E2f1,Psrc1,Ncaph,Nuf2,Tacc3,Ccnf,Cdca2,Mcm5,Fignl1,Cep55,Tpx2,Prc1,Kif20a,Kifc1"]
["mitotic cell cycle",40,1.53e-41,"Cdc20,Pole,Brca1,Cdk1,Ccng1,Aurkb,Kif18b,Plk2,Ska3,Pbk,Sgol1,Ndc80,Incenp,Cdca5,Rad51,Bub1,Cdk14,Bub1b,Ckap2,Ncapd2,Clspn,Anln,Kif4,E2f8,Kif2c,Espl1,Ttk,Top2a,Ccnb1,Nsl1,Birc5,Cdc6,E2f1,Psrc1,Ncaph,Tacc3,Cep55,Tpx2,Kif20a,Kifc1"]
["cell cycle process",44,1.18e-40,"Cdc20,Pole,Brca1,Cdk1,Ccng1,Aurkb,Kif18b,Plk2,Sgol1,Ndc80,Incenp,Cdca5,Rad51,Bub1,Cdk14,Ddias,Bub1b,Paf,Ckap2,Ncapd2,Clspn,Anln,Kif4,Timeless,Aspm,Kif2c,Espl1,Ttk,Top2a,Ccnb1,Nsl1,Birc5,E2f1,Psrc1,Ncaph,Nuf2,Tacc3,Ccnf,Fignl1,Cep55,Tpx2,Prc1,Kif20a,Kifc1"]
["cell division",39,9.59e-40,"Cdc20,Cdk1,Ccng1,Fam64a,Aurkb,Kif18b,Ska3,Sgol1,Ndc80,Incenp,Cdca5,Bub1,Cdk14,Ccnb2,Bub1b,Ckap2,Ncapd2,Anln,Kif4,Timeless,Aspm,Kif2c,Top2a,Ccnb1,Nsl1,Birc5,Cdc26,Cdc6,Psrc1,Ncaph,Nuf2,Tacc3,Ccnf,Cdca2,Cep55,Tpx2,Prc1,Kif20a,Kifc1"]
["mitotic cell cycle process",36,2.17e-37,"Cdc20,Pole,Brca1,Cdk1,Ccng1,Aurkb,Kif18b,Plk2,Sgol1,Ndc80,Incenp,Cdca5,Rad51,Bub1,Cdk14,Bub1b,Ckap2,Ncapd2,Clspn,Anln,Kif4,Kif2c,Espl1,Ttk,Top2a,Ccnb1,Nsl1,Birc5,E2f1,Psrc1,Ncaph,Tacc3,Cep55,Tpx2,Kif20a,Kifc1"]
["chromosome segregation",26,1.52e-27,"Cdc20,Brca1,Aurkb,Kif18b,Ska3,Esco2,Sgol1,Ndc80,Incenp,Cdca5,Bub1,Bub1b,Ncapd2,Kif4,Kif2c,Espl1,Ttk,Top2a,Ccnb1,Nsl1,Birc5,Psrc1,Ncaph,Nuf2,Cdca2,Kifc1"]
["nuclear division",24,5.11e-24,"Cdc20,Aurkb,Kif18b,Sgol1,Ndc80,Cdca5,Rad51,Bub1,Bub1b,Ncapd2,Kif4,Aspm,Kif2c,Espl1,Ttk,Top2a,Ccnb1,Nsl1,Birc5,Psrc1,Ncaph,Fignl1,Tpx2,Kifc1"]
["regulation of cell cycle",33,1.74e-21,"Cdc20,Brca1,Cdk1,Ccng1,Aurkb,Plk2,Ndc80,Cdca5,Dtl,Bub1,Cdk14,Ddias,Mki67,Bub1b,Paf,Clspn,E2f8,Aspm,Ttk,Top2a,Ccnb1,Birc5,Cdc26,Cdc6,E2f1,Psrc1,Tacc3,Ccnf,Fignl1,Tpx2,Prc1,Kif20a,Kifc1"]
["sister chromatid segregation",18,3.02e-21,"Cdc20,Aurkb,Kif18b,Sgol1,Ndc80,Cdca5,Bub1,Bub1b,Ncapd2,Kif4,Kif2c,Espl1,Top2a,Ccnb1,Nsl1,Psrc1,Ncaph,Kifc1"]
["nuclear chromosome segregation",20,6.82e-21,"Cdc20,Aurkb,Kif18b,Sgol1,Ndc80,Cdca5,Bub1,Bub1b,Ncapd2,Kif4,Kif2c,Espl1,Ttk,Top2a,Ccnb1,Nsl1,Psrc1,Ncaph,Nuf2,Kifc1"]
[]
[]
["Molecular Functions","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["ATP binding",27,8.17e-11,"Cdk1,Aurkb,Kif18b,Plk2,Pbk,Mcm4,Pkmyt1,Aldh18a1,Mcm6,Rad51,Bub1,Cdk14,Mki67,Bub1b,Atad2,Melk,Kif4,Mcm3,Kif2c,Ttk,Top2a,Cdk17,Cdc6,Mcm5,Fignl1,Kif20a,Kifc1"]
["drug binding",27,8.06e-10,"Cdk1,Aurkb,Kif18b,Plk2,Pbk,Mcm4,Pkmyt1,Aldh18a1,Mcm6,Rad51,Bub1,Cdk14,Mki67,Bub1b,Atad2,Melk,Kif4,Mcm3,Kif2c,Ttk,Top2a,Cdk17,Cdc6,Mcm5,Fignl1,Kif20a,Kifc1"]
["nucleotide binding",29,1.9e-09,"Uhrf1,Pole,Cdk1,Aurkb,Kif18b,Plk2,Pbk,Mcm4,Pkmyt1,Aldh18a1,Mcm6,Rad51,Bub1,Cdk14,Mki67,Bub1b,Atad2,Melk,Kif4,Mcm3,Kif2c,Ttk,Top2a,Cdk17,Cdc6,Mcm5,Fignl1,Kif20a,Kifc1"]
["small molecule binding",30,9.34e-09,"Uhrf1,Pole,Cdk1,Hmmr,Aurkb,Kif18b,Plk2,Pbk,Mcm4,Pkmyt1,Aldh18a1,Mcm6,Rad51,Bub1,Cdk14,Mki67,Bub1b,Atad2,Melk,Kif4,Mcm3,Kif2c,Ttk,Top2a,Cdk17,Cdc6,Mcm5,Fignl1,Kif20a,Kifc1"]
["carbohydrate derivative binding",28,9.34e-09,"Cdk1,Hmmr,Aurkb,Kif18b,Plk2,Pbk,Mcm4,Pkmyt1,Aldh18a1,Mcm6,Rad51,Bub1,Cdk14,Mki67,Bub1b,Atad2,Melk,Kif4,Mcm3,Kif2c,Ttk,Top2a,Cdk17,Cdc6,Mcm5,Fignl1,Kif20a,Kifc1"]
["anion binding",28,1.19e-06,"Cdk1,Hmmr,Aurkb,Kif18b,Plk2,Pbk,Mcm4,Pkmyt1,Aldh18a1,Mcm6,Rad51,Bub1,Cdk14,Mki67,Bub1b,Atad2,Melk,Kif4,Mcm3,Kif2c,Ttk,Top2a,Cdk17,Cdc6,Mcm5,Fignl1,Kif20a,Kifc1"]
["protein serine/threonine kinase activity",11,1.05e-05,"Cdk1,Aurkb,Plk2,Pbk,Pkmyt1,Bub1,Cdk14,Bub1b,Melk,Ttk,Cdk17"]
["transferase activity, transferring phosphorus-containing groups",15,1.12e-05,"Pole,Cdk1,Aurkb,Plk2,Pbk,Pkmyt1,Aldh18a1,Bub1,Cdk14,Bub1b,Melk,Ttk,Cdk17,Ccnb1,Pole4"]
["ATPase activity",10,1.85e-05,"Kif18b,Mcm4,Mcm6,Rad51,Atad2,Kif4,Kif2c,Top2a,Kif20a,Kifc1"]
["protein kinase activity",12,2.61e-05,"Cdk1,Aurkb,Plk2,Pbk,Pkmyt1,Bub1,Cdk14,Bub1b,Melk,Ttk,Cdk17,Ccnb1"]

{"sheet":"Cluster 2 (Aquamarine)","index":1,"n_rows":54,"n_cols":4,"rows_kept":54,"merged":[[0,0,0,3]],"flags":["formulas_cached_only"]}
["STRING PPI Network for WT-C vs. WT-D \nCluster 2 (Aquamarine)"]
["KEGG Pathway","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["Influenza A",13,{"v":3.52e-13,"d":"3.52E-13"},"Rsad2,Eif2ak2,Irf7,Ifih1,Oas3,Ddx58,Cxcl10,Oas2,Oas1a,Oas1g,Stat2,Adar,Irf9"]
["Measles",11,{"v":1.27e-11,"d":"1.27E-11"},"Eif2ak2,Irf7,Ifih1,Oas3,Ddx58,Oas2,Oas1a,Oas1g,Stat2,Adar,Irf9"]
["Herpes simplex infection",12,{"v":3.1e-11,"d":"3.10E-11"},"Eif2ak2,Irf7,Ifih1,Oas3,Ddx58,Oas2,Sp100,Oas1a,Oas1g,Ifit1,Stat2,Irf9"]
["NOD-like receptor signaling pathway",11,{"v":5.8e-11,"d":"5.80E-11"},"Irf7,Oas3,Gbp7,Oas2,Oas1a,Oas1g,Stat2,Gbp3,Ifi204,Tmem173,Irf9"]
["Hepatitis C",10,{"v":1.53e-10,"d":"1.53E-10"},"Eif2ak2,Irf7,Oas3,Ddx58,Oas2,Oas1a,Oas1g,Ifit1,Stat2,Irf9"]
["RIG-I-like receptor signaling pathway",7,1.89e-08,"Dhx58,Irf7,Ifih1,Ddx58,Cxcl10,Isg15,Tmem173"]
["Cytosolic DNA-sensing pathway",6,2.87e-07,"Irf7,Zbp1,Ddx58,Cxcl10,Adar,Tmem173"]
["Necroptosis",5,0.00061,"Eif2ak2,Zbp1,Mlkl,Stat2,Irf9"]
["Human papillomavirus infection",6,0.0024,"Eif2ak2,Oasl1,Oasl2,Isg15,Stat2,Irf9"]
["Hepatitis B",4,0.0035,"Irf7,Ifih1,Ddx58,Stat2"]
["Kaposi's sarcoma-associated herpesvirus infection",4,0.0104,"Eif2ak2,Irf7,Stat2,Irf9"]
["Viral carcinogenesis",4,0.0104,"Eif2ak2,Irf7,Sp100,Irf9"]
["TNF signaling pathway",3,0.0118,"Cxcl10,Mlkl,Ifi47"]
[]
[]
["Reactome Pathway","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["Antiviral mechanism by IFN-stimulated genes",6,5.76e-08,"Eif2ak2,Oasl1,Usp18,Uba7,Ddx58,Isg15"]
["Interferon Signaling",7,6.59e-08,"Eif2ak2,Oasl1,Usp18,Uba7,Ddx58,Isg15,Irf9"]
["ISG15 antiviral mechanism",5,5.88e-07,"Eif2ak2,Usp18,Uba7,Ddx58,Isg15"]
["Immune System",15,0.0016,"Eif2ak2,Ifitm3,Irf7,Oasl1,Herc6,Usp18,Uba7,Ddx58,Bst2,Dtx3l,Isg15,Rnf213,Ifi204,Tmem173,Irf9"]
["OAS antiviral response",2,0.0029,"Oasl1,Ddx58"]
["Nicotinamide salvaging",2,0.0156,"Parp14,Parp9"]
["DDX58/IFIH1-mediated induction of interferon-alpha/beta",2,0.0346,"Irf7,Ddx58"]
["Cytosolic sensors of pathogen-associated DNA",2,0.0346,"Irf7,Tmem173"]
["Termination of translesion DNA synthesis",2,0.0346,"Uba7,Isg15"]
["Interferon alpha/beta signaling",2,0.0346,"Usp18,Irf9"]
[]
[]
["Biological Processes","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["defense response to virus",29,8.87e-40,"Dhx58,Rsad2,Eif2ak2,Ifitm3,Irf7,Ifih1,Zbp1,Oasl1,Oasl2,Oas3,Rtp4,Ddx58,Ifi44l,Cxcl10,Bst2,Trim34a,Oas2,Trim30a,Oas1a,Dtx3l,Isg15,Ifit1,Ifit3,Ifit2,Stat2,Adar,Mx1,Parp9,Tmem173"]
["response to virus",30,1.42e-37,"Dhx58,Rsad2,Eif2ak2,Ifitm3,Irf7,Ifih1,Zbp1,Oasl1,Oasl2,Oas3,Rtp4,Ddx58,Ifi44l,Cxcl10,Bst2,Ifi27l2a,Trim34a,Oas2,Trim30a,Oas1a,Dtx3l,Isg15,Ifit1,Ifit3,Ifit2,Stat2,Adar,Mx1,Parp9,Tmem173"]
["response to other organism",38,5.08e-29,"Dhx58,Cmpk2,Rsad2,Eif2ak2,Ifitm3,Irf7,Ifih1,Zbp1,Ifi44,Oasl1,Oasl2,Herc6,Usp18,Oas3,Parp14,Rtp4,Ddx58,Ifi44l,Cxcl10,Irgm1,Bst2,Ifi27l2a,Trim34a,Oas2,Trim30a,Oas1a,Dtx3l,Isg15,Ifit1,Ifit3,Ifit2,Stat2,Gbp3,Adar,Ifi204,Mx1,Parp9,Tmem173"]
["defense response to other organism",33,1.52e-27,"Dhx58,Rsad2,Eif2ak2,Ifitm3,Irf7,Ifih1,Zbp1,Oasl1,Oasl2,Herc6,Oas3,Parp14,Rtp4,Ddx58,Ifi44l,Cxcl10,Irgm1,Bst2,Trim34a,Oas2,Trim30a,Oas1a,Dtx3l,Isg15,Ifit1,Ifit3,Ifit2,Stat2,Gbp3,Adar,Mx1,Parp9,Tmem173"]
["innate immune response",29,5.57e-26,"Dhx58,Rsad2,Eif2ak2,Ifitm3,Irf7,Ifih1,Zbp1,Oasl1,Oasl2,Herc6,Oas3,Parp14,Ddx58,Irgm1,Bst2,Oas2,Trim30a,Oas1a,Dtx3l,Isg15,Ifit1,Ifit3,Ifit2,Stat2,Gbp3,Adar,Mx1,Parp9,Tmem173"]
["immune response",31,3.24e-22,"Dhx58,Rsad2,Eif2ak2,Ifitm3,Irf7,Ifih1,Zbp1,Oasl1,Oasl2,Herc6,Oas3,Parp14,Ddx58,Ifi44l,Cxcl10,Irgm1,Bst2,Oas2,Trim30a,Oas1a,Dtx3l,Isg15,Ifit1,Ifit3,Ifit2,Stat2,Gbp3,Adar,Mx1,Parp9,Tmem173"]
["multi-organism process",38,5.87e-19,"Dhx58,Cmpk2,Rsad2,Eif2ak2,Ifitm3,Irf7,Ifih1,Zbp1,Ifi44,Oasl1,Oasl2,Herc6,Usp18,Oas3,Parp14,Rtp4,Ddx58,Ifi44l,Cxcl10,Irgm1,Bst2,Ifi27l2a,Trim34a,Oas2,Trim30a,Oas1a,Dtx3l,Isg15,Ifit1,Ifit3,Ifit2,Stat2,Gbp3,Adar,Ifi204,Mx1,Parp9,Tmem173"]
["immune system process",33,1.12e-16,"Dhx58,Rsad2,Eif2ak2,Ifitm3,Irf7,Ifih1,Zbp1,Oasl1,Oasl2,Herc6,Oas3,Parp14,Rtp4,Ddx58,Ifi44l,Cxcl10,Irgm1,Bst2,Trim34a,Oas2,Trim30a,Oas1a,Dtx3l,Isg15,Ifit1,Ifit3,Ifit2,Stat2,Gbp3,Adar,Mx1,Parp9,Tmem173"]
["response to interferon-beta",11,2.09e-16,"Ifitm3,Irgm1,Bst2,Pyhin1,Ifit1,Ifit3,Gbp3,Ifi204,Tmem173,Ifi203,Xaf1"]
["regulation of multi-organism process",20,2.73e-14,"Dhx58,Rsad2,Eif2ak2,Ifitm3,Irf7,Ifih1,Zbp1,Oasl1,Oas3,Parp14,Ddx58,Irgm1,Bst2,Trim30a,Oas1a,Dtx3l,Isg15,Adar,Parp9,Tmem173"]
[]
[]
["Molecular Functions","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["double-stranded RNA binding",9,5.51e-10,"Dhx58,Eif2ak2,Ifih1,Oasl1,Oasl2,Oas3,Ddx58,Oas2,Oas1a"]
["2'-5'-oligoadenylate synthetase activity",4,4.85e-07,"Oasl2,Oas3,Oas2,Oas1a"]
["RNA binding",13,0.0005,"Dhx58,Eif2ak2,Ifih1,Zbp1,Oasl1,Oasl2,Oas3,Ddx58,Oas2,Oas1a,Ifit1,Ifit2,Adar"]
["carbohydrate derivative binding",19,0.0005,"Dhx58,Cmpk2,Eif2ak2,Ifih1,Oasl1,Oasl2,Oas3,Ddx58,Cxcl10,Irgm1,Mlkl,Oas2,Tor3a,Oas1a,Helz2,Gbp3,Mx1,Parp9,Tmem173"]
["heterocyclic compound binding",31,0.0005,"Dhx58,Cmpk2,Eif2ak2,Irf7,Ifih1,Zbp1,Oasl1,Oasl2,Oas3,Parp14,Ddx58,Irgm1,Mlkl,Oas2,Pyhin1,Sp100,Trim30a,Tor3a,Oas1a,Helz2,Ifit1,Ifit2,Stat2,Gbp3,Adar,Ifi204,Mx1,Parp9,Tmem173,Irf9,Ifi203"]
["nucleotide binding",18,0.00052,"Dhx58,Cmpk2,Eif2ak2,Ifih1,Oasl1,Oasl2,Oas3,Parp14,Ddx58,Irgm1,Mlkl,Oas2,Tor3a,Oas1a,Helz2,Gbp3,Mx1,Tmem173"]
["core promoter sequence-specific DNA binding",5,0.00052,"Irf7,Pyhin1,Ifi204,Irf9,Ifi203"]
["NAD+ ADP-ribosyltransferase activity",3,0.00052,"Parp14,Parp12,Parp9"]
["purine ribonucleotide binding",17,0.00052,"Dhx58,Cmpk2,Eif2ak2,Ifih1,Oasl1,Oasl2,Oas3,Ddx58,Irgm1,Mlkl,Oas2,Tor3a,Oas1a,Helz2,Gbp3,Mx1,Tmem173"]
["organic cyclic compound binding",31,0.00052,"Dhx58,Cmpk2,Eif2ak2,Irf7,Ifih1,Zbp1,Oasl1,Oasl2,Oas3,Parp14,Ddx58,Irgm1,Mlkl,Oas2,Pyhin1,Sp100,Trim30a,Tor3a,Oas1a,Helz2,Ifit1,Ifit2,Stat2,Gbp3,Adar,Ifi204,Mx1,Parp9,Tmem173,Irf9,Ifi203"]

{"sheet":"Cluster 3 (Sky Blue)","index":2,"n_rows":41,"n_cols":4,"rows_kept":41,"merged":[[0,0,0,3]],"flags":["formulas_cached_only"]}
["STRING PPI Network for WT-C vs. WT-D \nCluster 3 (Sky Blue)"]
["KEGG Pathway","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["Leishmaniasis",5,{"v":4.28e-06,"d":"4.28E-06"},"Itgb2,Cybb,Itga4,Fcgr3,Ncf2"]
["Phagosome",5,{"v":0.00018,"d":"1.80E-04"},"Itgb2,Cybb,Ctss,Fcgr3,Ncf2"]
["Tuberculosis",5,{"v":0.00018,"d":"1.80E-04"},"Itgb2,Ctss,Il10ra,Fcer1g,Fcgr3"]
["Leukocyte transendothelial migration",4,{"v":0.00055,"d":"5.50E-04"},"Itgb2,Cybb,Itga4,Ncf2"]
["Osteoclast differentiation",3,{"v":0.0138,"d":"1.38E-02"},"Lilrb4,Fcgr3,Ncf2"]
["Cell adhesion molecules (CAMs)",3,0.0238,"Itgb2,Cd86,Itga4"]
["Intestinal immune network for IgA production",2,0.0238,"Cd86,Itga4"]
["Staphylococcus aureus infection",2,0.0294,"Itgb2,Fcgr3"]
[]
[]
["Reactome Pathway","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["Innate Immune System",9,0.00022,"Hck,Cybb,Ctss,Cd53,Pld4,Fcer1g,Lair1,Lilrb4,Ncf2"]
["Immune System",11,0.00022,"Hck,Cybb,Ctss,Il10ra,Cd53,Pld4,Fcer1g,Lair1,Cd86,Lilrb4,Ncf2"]
["Neutrophil degranulation",6,0.0015,"Cybb,Ctss,Cd53,Fcer1g,Lair1,Lilrb4"]
["Cross-presentation of particulate exogenous antigens (phagosomes)",2,0.0016,"Cybb,Ncf2"]
["RHO GTPases Activate NADPH Oxidases",2,0.0037,"Cybb,Ncf2"]
["ROS, RNS production in phagocytes",2,0.0161,"Cybb,Ncf2"]
["Detoxification of Reactive Oxygen Species",2,0.0161,"Cybb,Ncf2"]
["Adaptive Immune System",5,0.0239,"Cybb,Ctss,Lair1,Cd86,Ncf2"]
[]
[]
["Biological Processes","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["phagocytosis",9,9.55e-11,"Itgb2,Hck,Aif1,Fcgr2b,Pld4,Fcer1g,Arhgap25,Fcgr3,Ncf2"]
["phagocytosis, engulfment",6,8.67e-09,"Itgb2,Aif1,Fcgr2b,Fcer1g,Arhgap25,Fcgr3"]
["endocytosis",10,4.86e-08,"Itgb2,Hck,Aif1,Fcgr2b,Pld4,Fcer1g,Itga4,Arhgap25,Fcgr3,Ncf2"]
["import into cell",10,2.6e-07,"Itgb2,Hck,Aif1,Fcgr2b,Pld4,Fcer1g,Itga4,Arhgap25,Fcgr3,Ncf2"]
["immune system process",15,2.9e-07,"Itgb2,Hck,Cybb,Ctss,Aif1,Fcgr2b,Themis2,Pld4,Fcer1g,Emr1,Myo1f,Cd86,Itga4,Lilrb4,Fcgr3"]
["immune response",11,3.29e-06,"Hck,Cybb,Ctss,Aif1,Fcgr2b,Fcer1g,Emr1,Myo1f,Cd86,Lilrb4,Fcgr3"]
["vesicle-mediated transport",11,8.85e-06,"Itgb2,Hck,Aif1,Fcgr2b,Pld4,Fcer1g,Myo1f,Itga4,Arhgap25,Fcgr3,Ncf2"]
["regulation of type I hypersensitivity",3,1.42e-05,"Fcgr2b,Fcer1g,Fcgr3"]
["antigen processing and presentation of peptide antigen",4,2.1e-05,"Ctss,Fcgr2b,Fcer1g,Fcgr3"]
["Fc-gamma receptor signaling pathway",3,6.03e-05,"Fcgr2b,Fcer1g,Fcgr3"]
[]
["Molecular Functions","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["immunoglobulin receptor activity",3,5.91e-05,"Fcgr2b,Fcer1g,Fcgr3"]
["IgG binding",3,5.91e-05,"Fcgr2b,Fcer1g,Fcgr3"]
["IgG receptor activity",2,0.0014,"Fcgr2b,Fcgr3"]
["fibronectin binding",2,0.0265,"Ctss,Itga4"]
["transmembrane signaling receptor activity",6,0.0278,"Itgb2,Fcgr2b,Il10ra,Fcer1g,Emr1,Fcgr3"]

{"sheet":"Cluster 4 (Cornflower Blue)","index":3,"n_rows":52,"n_cols":4,"rows_kept":52,"merged":[[0,0,0,3]],"flags":["formulas_cached_only"]}
["STRING PPI Network for WT-C vs. WT-D \nCluster 4 (Cornflower Blue)"]
["KEGG Pathway","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["Protein digestion and absorption",8,{"v":7.61e-12,"d":"7.61E-12"},"Col6a1,Col6a2,Col1a1,Col5a1,Col1a2,Col4a1,Col4a2,Col5a2"]
["ECM-receptor interaction",7,{"v":1.55e-10,"d":"1.55E-10"},"Col6a1,Col6a2,Col1a1,Col1a2,Col4a1,Col4a2,Hspg2"]
["Focal adhesion",6,{"v":1.19e-06,"d":"1.19E-06"},"Col6a1,Col6a2,Col1a1,Col1a2,Col4a1,Col4a2"]
["Human papillomavirus infection",6,{"v":1.94e-05,"d":"1.94E-05"},"Col6a1,Col6a2,Col1a1,Col1a2,Col4a1,Col4a2"]
["PI3K-Akt signaling pathway",6,{"v":1.96e-05,"d":"1.96E-05"},"Col6a1,Col6a2,Col1a1,Col1a2,Col4a1,Col4a2"]
["AGE-RAGE signaling pathway in diabetic complications",4,2.86e-05,"Col1a1,Col1a2,Col4a1,Col4a2"]
["Amoebiasis",4,2.95e-05,"Col1a1,Col1a2,Col4a1,Col4a2"]
["Relaxin signaling pathway",4,5.82e-05,"Col1a1,Col1a2,Col4a1,Col4a2"]
["Proteoglycans in cancer",4,0.00026,"Col1a1,Col1a2,Dcn,Hspg2"]
["Small cell lung cancer",2,0.0115,"Col4a1,Col4a2"]
["Platelet activation",2,0.0178,"Col1a1,Col1a2"]
[]
[]
["Reactome Pathway","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["Extracellular matrix organization",18,{"v":3.21e-26,"d":"3.21E-26"},"Col6a1,Col6a2,Col1a1,Sparc,Col5a1,Fbn1,Col1a2,Pcolce,Bgn,Col4a1,Col4a2,Col16a1,Adamts2,Efemp2,Col5a2,Dcn,Lox,Hspg2"]
["Collagen formation",12,{"v":7.8e-20,"d":"7.80E-20"},"Col6a1,Col6a2,Col1a1,Col5a1,Col1a2,Pcolce,Col4a1,Col4a2,Col16a1,Adamts2,Col5a2,Lox"]
["Collagen biosynthesis and modifying enzymes",11,{"v":1.65e-19,"d":"1.65E-19"},"Col6a1,Col6a2,Col1a1,Col5a1,Col1a2,Pcolce,Col4a1,Col4a2,Col16a1,Adamts2,Col5a2"]
["Integrin cell surface interactions",11,{"v":3.67e-19,"d":"3.67E-19"},"Col6a1,Col6a2,Col1a1,Col5a1,Fbn1,Col1a2,Col4a1,Col4a2,Col16a1,Col5a2,Hspg2"]
["ECM proteoglycans",10,{"v":4.91e-19,"d":"4.91E-19"},"Col6a1,Col6a2,Col1a1,Sparc,Col5a1,Col1a2,Bgn,Col5a2,Dcn,Hspg2"]
["Assembly of collagen fibrils and other multimeric structures",10,{"v":1.69e-17,"d":"1.69E-17"},"Col6a1,Col6a2,Col1a1,Col5a1,Col1a2,Pcolce,Col4a1,Col4a2,Col5a2,Lox"]
["Degradation of the extracellular matrix",11,{"v":5.95e-17,"d":"5.95E-17"},"Col6a1,Col6a2,Col1a1,Col5a1,Fbn1,Col1a2,Col4a1,Col4a2,Col5a2,Dcn,Hspg2"]
["Collagen chain trimerization",9,{"v":5.95e-17,"d":"5.95E-17"},"Col6a1,Col6a2,Col1a1,Col5a1,Col1a2,Col4a1,Col4a2,Col16a1,Col5a2"]
["Collagen degradation",8,{"v":2.9e-13,"d":"2.90E-13"},"Col6a1,Col6a2,Col1a1,Col5a1,Col1a2,Col4a1,Col4a2,Col5a2"]
["Non-integrin membrane-ECM interactions",7,{"v":5.04e-13,"d":"5.04E-13"},"Col1a1,Col5a1,Col1a2,Col4a1,Col4a2,Col5a2,Hspg2"]
[]
[]
["Biological Processes","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["extracellular matrix organization",9,1.38e-09,"Col1a1,Col5a1,Col1a2,Col4a1,Adamts2,Efemp2,Postn,Col5a2,Lox"]
["collagen fibril organization",6,6.95e-09,"Col1a1,Col5a1,Col1a2,Adamts2,Col5a2,Lox"]
["cellular response to amino acid stimulus",6,9.25e-08,"Col6a1,Col1a1,Col1a2,Col4a1,Col16a1,Col5a2"]
["protein heterotrimerization",4,3.26e-06,"Col6a1,Col6a2,Col1a1,Col1a2"]
["response to organic substance",15,1.62e-05,"Col6a1,Col6a2,Col1a1,Sparc,Fbn1,Col1a2,Pcolce,Bgn,Col4a1,Col4a2,Col16a1,Postn,Col5a2,Dcn,Lox"]
["response to acid chemical",7,1.8e-05,"Col6a1,Col1a1,Sparc,Col1a2,Col4a1,Col16a1,Col5a2"]
["cellular response to organic substance",13,1.8e-05,"Col6a1,Col1a1,Sparc,Fbn1,Col1a2,Pcolce,Bgn,Col4a1,Col4a2,Col16a1,Postn,Col5a2,Dcn"]
["collagen metabolic process",4,2.23e-05,"Col1a1,Col5a1,Adamts2,Mrc2"]
["response to endogenous stimulus",11,2.38e-05,"Col6a1,Col1a1,Sparc,Fbn1,Col1a2,Col4a1,Col4a2,Col16a1,Postn,Col5a2,Lox"]
["collagen-activated tyrosine kinase receptor signaling pathway",3,2.67e-05,"Col1a1,Col4a1,Col4a2"]
[]
[]
["Molecular Functions","Observed Gene Count","False Discovery Rate (FDR)","Matching Proteins"]
["extracellular matrix structural constituent",7,2.47e-11,"Col1a1,Col5a1,Fbn1,Col1a2,Col4a1,Col4a2,Col5a2"]
["platelet-derived growth factor binding",5,8.07e-10,"Col6a1,Col1a1,Col5a1,Col1a2,Col4a1"]
["glycosaminoglycan binding",7,1.4e-07,"Wisp1,Col5a1,Fbn1,Pcolce,Bgn,Postn,Dcn"]
["growth factor binding",6,7.06e-07,"Col6a1,Col1a1,Wisp1,Col5a1,Col1a2,Col4a1"]
["collagen binding",4,2.16e-05,"Sparc,Pcolce,Mrc2,Dcn"]
["heparin binding",5,2.16e-05,"Wisp1,Col5a1,Fbn1,Pcolce,Postn"]
["extracellular matrix binding",4,2.16e-05,"Sparc,Bgn,Cd248,Dcn"]
["metal ion binding",13,0.0018,"Col1a1,Fkbp10,Sparc,Fbn1,Col1a2,Adamts2,Loxl1,Efemp2,Cd248,Postn,Col5a2,Aebp1,Lox"]
["oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor",2,0.0021,"Loxl1,Lox"]
["ion binding",16,0.0023,"Col1a1,Fkbp10,Wisp1,Sparc,Col5a1,Fbn1,Col1a2,Pcolce,Adamts2,Loxl1,Efemp2,Cd248,Postn,Col5a2,Aebp1,Lox"]