Protein Description Gene F_ C F_.vs.C FC F_.vs.C Pvalue F_.vs.C log2FC F_.vs.C UP.DOWN GO_NUM GO_Description KEGG_Description KEGG_EC KEGG_ko KOGs_Function_Description KOGs_Function_Class KOGs_Class_Description IPR_Term Subcellular_localization TF_family A0A8B9WIU4 Carbamoyl-phosphate synthase 1 CPS1 1183704537.83448 108340366.8125 10.9257940752874 0.00389335945397085 3.44966623199058 up 1 Molecular Function:ATP binding (GO:0005524) carbamoyl-phosphate synthase (ammonia) 6.3.4.16 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00910 Nitrogen metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) R General function prediction only ; IPR002474 [Carbamoyl-phosphate synthase, small subunit N-terminal domain] ; IPR005479 [Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain] ; IPR005480 [Carbamoyl-phosphate synthetase, large subunit oligomerisation domain] ; IPR011607 [Methylglyoxal synthase-like domain] ; IPR017926 [Glutamine amidotransferase] mitochondrion protein -- A0A8B9YWT4 Maestro heat like repeat family member 2B MROH2B 50907453.9779142 148779976.9375 0.342166029500728 0.0420189515181052 -1.5472315597929 down -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- A0A8B9XTT1 EF-hand calcium binding domain 6 EFCAB6 111125491.997867 326665297.75 0.340181503095907 0.0410615397687258 -1.5556233963237 down 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Calmodulin and related proteins (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] ; IPR015070 [DJBP, EF-hand domain] nucleus protein -- A0A8B9WHL7 Vasoactive intestinal peptide VIP 4066152907.84676 959901200.75 4.23601189858889 0.047965894442257 2.0827066417408 up 2 Molecular Function:hormone activity (GO:0005179),Cellular Component:extracellular region (GO:0005576) vasoactive intestinal peptide -- -- -- -- -- IPR000532 [Glucagon/GIP/secretin/VIP] extracell protein -- A0A8B9YHP1 hyaluronoglucosaminidase CEMIP 27466925.8837899 80745163.6875 0.340168062450061 0.0410550974674532 -1.55568039864749 down -- -- cell migration-inducing and hyaluronan-binding protein 3.2.1.35 -- -- -- -- IPR019316 [G8 domain] ; IPR025155 [WxxW domain] extracell protein -- A0A8B9XQ86 Heat shock protein 90 alpha family class A member 1 HSP90AA1 720239.434166325 2998334 0.240213209791279 0.00858482388819348 -2.05761260505801 down 4 Molecular Function:ATP binding (GO:0005524),Biological Process:protein folding (GO:0006457),Biological Process:response to stress (GO:0006950),Molecular Function:unfolded protein binding (GO:0051082) molecular chaperone HtpG -- ko04141 Protein processing in endoplasmic reticulum ko04151 PI3K-Akt signaling pathway ko04217 Necroptosis ko04612 Antigen processing and presentation ko04621 NOD-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04659 Th17 cell differentiation ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko05200 Pathways in cancer ko05215 Prostate cancer ko05418 Fluid shear stress and atherosclerosis Molecular chaperone (HSP90 family) O Posttranslational modification, protein turnover, chaperones ; IPR001404 [Heat shock protein Hsp90 family] ; IPR003594 [Histidine kinase-like ATPase, C-terminal domain] cytoplasm protein -- A0A8B9XLC7 Heat shock protein family A (Hsp70) member 8 HSPA8 145161030.218013 9568867.6875 15.1701366304437 0.00132234066631635 3.92316217422154 up -- -- heat shock 70kDa protein 1/2/6/8 -- ko03040 Spliceosome ko04010 MAPK signaling pathway ko04141 Protein processing in endoplasmic reticulum ko04144 Endocytosis ko04213 Longevity regulating pathway - multiple species ko04612 Antigen processing and presentation ko04915 Estrogen signaling pathway ko05134 Legionellosis ko05145 Toxoplasmosis ko05162 Measles ko05164 Influenza A ko05169 Epstein-Barr virus infection Molecular chaperones HSP70/HSC70, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] mitochondrion protein -- A0A8B9XKM5 Kelch like family member 10 KLHL10 25805460.2807644 123269058.585938 0.20934255989936 0.0041714879861622 -2.25606244973504 down 1 Molecular Function:protein binding (GO:0005515) kelch-like protein 10 -- -- Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes TR Signal transduction mechanisms ; General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR006652 [Kelch repeat type 1] ; IPR011705 [BTB/Kelch-associated] cytoskeleton protein ZBTB A0A8B9WWG9 Heat shock protein 90 alpha family class B member 1 HSP90AB1 54700215.6098296 10479880.53125 5.21954572351458 0.0297527493265436 2.38392424914151 up 4 Molecular Function:ATP binding (GO:0005524),Biological Process:protein folding (GO:0006457),Biological Process:response to stress (GO:0006950),Molecular Function:unfolded protein binding (GO:0051082) molecular chaperone HtpG -- ko04141 Protein processing in endoplasmic reticulum ko04151 PI3K-Akt signaling pathway ko04217 Necroptosis ko04612 Antigen processing and presentation ko04621 NOD-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04659 Th17 cell differentiation ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko05200 Pathways in cancer ko05215 Prostate cancer ko05418 Fluid shear stress and atherosclerosis Molecular chaperone (HSP90 family) O Posttranslational modification, protein turnover, chaperones ; IPR001404 [Heat shock protein Hsp90 family] ; IPR003594 [Histidine kinase-like ATPase, C-terminal domain] cytoplasm protein -- A0A8C0AAY2 Sperm associated antigen 17 SPAG17 23254660.4730885 73070525.5 0.318249531038182 0.0313050384313978 -1.65176970666611 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9Y2J7 EF-hand calcium binding domain 5 EFCAB5 10382348.9494138 34340179.0625 0.302338229818711 0.0251760666590582 -1.72576467965747 down -- -- -- -- -- -- -- -- -- -- -- A0A8C0A7C6 Outer dense fiber protein 1 ODF1 1297595146.56873 4752611025.74219 0.273027845018327 0.0159421915906671 -1.87288000153967 down -- -- -- -- -- -- -- -- IPR002068 [Alpha crystallin/Hsp20 domain] nucleus protein -- A0A8B9XFR3 ATP-citrate synthase ACLY 56335808.8038594 4024507.84375 13.9981858629865 0.00174042566030562 3.80716796376756 up 3 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152),Molecular Function:cofactor binding (GO:0048037) ATP citrate (pro-S)-lyase 2.3.3.8 ko00020 Citrate cycle (TCA cycle) ko01100 Metabolic pathways ATP-citrate lyase C Energy production and conversion ; IPR002020 [Citrate synthase] ; IPR003781 [CoA-binding] ; IPR005811 [ATP-citrate lyase/succinyl-CoA ligase] ; IPR032263 [ATP-citrate synthase, citrate-binding domain] cytoplasm protein -- A0A8C0A6L0 Adenosylhomocysteinase AHCY 368592943.562018 20087087.1875 18.3497457904892 0.000672131915412988 4.19768817161575 up 3 Molecular Function:adenosylhomocysteinase activity (GO:0004013),Biological Process:S-adenosylhomocysteine catabolic process (GO:0019510),Molecular Function:NAD binding (GO:0051287) adenosylhomocysteinase 3.3.1.1 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways S-adenosylhomocysteine hydrolase H Coenzyme transport and metabolism ; IPR000043 [Adenosylhomocysteinase] ; IPR015878 [S-adenosyl-L-homocysteine hydrolase, NAD binding domain] cytoplasm protein -- A0A8B9Y1Z0 Dihydroxyacetone phosphate acyltransferase GNPAT 15223612.0137443 55348902.75 0.275048126654043 0.0164951867574155 -1.86224401803074 down 1 Biological Process:metabolic process (GO:0008152) glyceronephosphate O-acyltransferase 2.3.1.42 ko00564 Glycerophospholipid metabolism ko04146 Peroxisome Acyl-CoA:dihydroxyactetone-phosphate acyltransferase DHAPAT I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] -- -- A0A8B9WME9 Betaine--homocysteine S-methyltransferase BHMT 1087690438.05831 238409143.75 4.56228490631585 0.0406733251309793 2.18975654311971 up -- -- betaine-homocysteine S-methyltransferase 2.1.1.5 ko00260 Glycine, serine and threonine metabolism ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways Homocysteine S-methyltransferase E Amino acid transport and metabolism ; IPR003726 [Homocysteine-binding domain] cytoplasm protein -- A0A8B9X4Z3 UTP--glucose-1-phosphate uridylyltransferase UGP2 82642017.9221586 8518413.75 9.70157359662867 0.00560273314047037 3.2782187716222 up 2 Biological Process:metabolic process (GO:0008152),Molecular Function:uridylyltransferase activity (GO:0070569) UTP--glucose-1-phosphate uridylyltransferase 2.7.7.9 ko00040 Pentose and glucuronate interconversions ko00052 Galactose metabolism ko00500 Starch and sucrose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways UDP-glucose pyrophosphorylase G Carbohydrate transport and metabolism ; IPR002618 [UDPGP family] cytoplasm protein -- A0A8B9WUY5 isoleucine--tRNA ligase IARS2 36843102.8522588 104941326.125 0.3510828785256 0.0464721399389785 -1.51011645374846 down 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) isoleucyl-tRNA synthetase 6.1.1.5 ko00970 Aminoacyl-tRNA biosynthesis Isoleucyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002300 [Aminoacyl-tRNA synthetase, class Ia] ; IPR010663 [Zinc finger, FPG/IleRS-type] ; IPR013155 [Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding] cytoplasm protein -- A0A8B9YHD4 10-formyltetrahydrofolate dehydrogenase ALDH1L1 110346226.67035 2761991.40625 39.9516908056455 2.85526907080144e-05 5.3201846559956 up 4 Biological Process:metabolic process (GO:0008152),Biological Process:biosynthetic process (GO:0009058),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) formyltetrahydrofolate dehydrogenase 1.5.1.6 ko00670 One carbon pool by folate Formyltetrahydrofolate dehydrogenase F Nucleotide transport and metabolism ; IPR002376 [Formyl transferase, N-terminal] ; IPR005793 [Formyl transferase, C-terminal] ; IPR009081 [Phosphopantetheine binding ACP domain] ; IPR015590 [Aldehyde dehydrogenase domain] cytoplasm protein -- A0A8B9XK15 Radixin RDX 17110597.3987007 4108699.359375 4.16448026542967 0.0497793094031738 2.05813645590905 up 3 Cellular Component:cytoplasm (GO:0005737),Molecular Function:cytoskeletal protein binding (GO:0008092),Cellular Component:extrinsic component of membrane (GO:0019898) radixin -- ko04530 Tight junction ko04810 Regulation of actin cytoskeleton ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer Radixin, moesin and related proteins of the ERM family R General function prediction only ; IPR011259 [Ezrin/radixin/moesin, C-terminal] ; IPR018979 [FERM, N-terminal] ; IPR018980 [FERM, C-terminal PH-like domain] ; IPR019748 [FERM central domain] cytoplasm protein -- A0A8B9WHR4 Protein disulfide-isomerase P4HB 292015011.56324 52031751.5 5.61224642924503 0.0249561657934948 2.4885783579322 up 1 Biological Process:cell redox homeostasis (GO:0045454) protein disulfide-isomerase A1 5.3.4.1 ko04141 Protein processing in endoplasmic reticulum Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] endoplasmic reticulum protein -- A0A8B9YCD6 Alpha-1,4 glucan phosphorylase PYGL 109122344.523042 6426194.5 16.9808655064894 0.000889511202142153 4.08583808911976 up 2 Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:glycogen phosphorylase activity (GO:0008184) glycogen phosphorylase 2.4.1.1 ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways ko04217 Necroptosis ko04910 Insulin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance Glycogen phosphorylase G Carbohydrate transport and metabolism ; IPR000811 [Glycosyl transferase, family 35] -- -- A0A8B9YTG3 Actinin alpha 4 ACTN4 22112126.5037667 257055.90625 86.0206903095295 6.79734979602933e-07 6.4266118037349 up 1 Molecular Function:protein binding (GO:0005515) actinin alpha 1/4 -- ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05146 Amoebiasis ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002017 [Spectrin repeat] ; IPR014837 [EF-hand, Ca insensitive] cytoskeleton protein -- A0A8B9WAJ3 Peroxiredoxin 1 213432764.487215 17406292.875 12.261816230483 0.00269723942980717 3.61610078294079 up 3 Molecular Function:antioxidant activity (GO:0016209),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) peroxiredoxin 1 1.11.1.15 ko04146 Peroxisome Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes O Posttranslational modification, protein turnover, chaperones ; IPR000866 [Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant] cytoplasm protein -- A0A8C0ALD9 glutamate dehydrogenase [NAD(P)(+)] 310032404.214676 7374481.59375 42.0412472759351 2.27057683115934e-05 5.39373356656883 up 3 Biological Process:cellular amino acid metabolic process (GO:0006520),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) glutamate dehydrogenase (NAD(P)+) 1.4.1.3 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00471 D-Glutamine and D-glutamate metabolism ko00910 Nitrogen metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04217 Necroptosis ko04964 Proximal tubule bicarbonate reclamation Glutamate/leucine/phenylalanine/valine dehydrogenases E Amino acid transport and metabolism ; IPR006096 [Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal] ; IPR006097 [Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain] mitochondrion protein -- A0A8B9XRW7 Sperm flagellar 2 SPEF2 9242069.96665112 296352245.4375 0.0311860973180993 3.52670793420261e-10 -5.00295316710778 down -- -- -- -- -- -- -- -- IPR010441 [CH-like domain in sperm protein] -- -- A0A8B9YBA4 Leucine rich repeat containing 23 LRRC23 6696457.42028699 19694228.0625 0.340021319903256 0.0409847983578188 -1.5563028863056 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- Protein phosphatase 1, regulatory subunit, and related proteins T Signal transduction mechanisms ; IPR001611 [Leucine-rich repeat] centrosome protein -- A0A8B9YG47 Acetyl-CoA acyltransferase 2 ACAA2 261029927.374564 35425704.125 7.36837654527675 0.0123208296287285 2.88134678918748 up 1 Biological Process:metabolic process (GO:0008152) acetyl-CoA acyltransferase 2 2.3.1.16 ko00062 Fatty acid elongation ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism Acetyl-CoA acetyltransferase I Lipid transport and metabolism ; IPR020616 [Thiolase, N-terminal] ; IPR020617 [Thiolase, C-terminal] cytoplasm protein -- A0A8B9XH10 Coiled-coil domain containing 63 CCDC63 14077025.6142201 45126604.5 0.311945154531183 0.0287812848853459 -1.6806356947783 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9WRG6 Isocitrate dehydrogenase [NADP] IDH1 132111580.839752 11854416.4375 11.1445031087176 0.00365894629443129 3.47826038859855 up 1 Biological Process:oxidation-reduction process (GO:0055114) isocitrate dehydrogenase 1.1.1.42 ko00020 Citrate cycle (TCA cycle) ko00480 Glutathione metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids ko04146 Peroxisome NADP-dependent isocitrate dehydrogenase C Energy production and conversion ; IPR024084 [Isopropylmalate dehydrogenase-like domain] peroxisome protein -- A0A8B9YB67 Importin 5 IPO5 13303618.6022999 50661599.6875 0.262597681169992 0.0132770641711005 -1.92907391810562 down 1 Molecular Function:protein binding (GO:0005515) importin-5 -- -- Karyopherin (importin) beta 3 YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR000357 [HEAT repeat] nucleus protein -- A0A8C0A9U8 Polypeptide N-acetylgalactosaminyltransferase GALNT10 7560011.51242159 26645949.625 0.28372085134202 0.0190075311273123 -1.81745591317782 down -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173 [Glycosyltransferase 2-like] Golgi apparatus protein -- A0A8B9W188 Fructose-bisphosphate aldolase 456788506.744688 11841695 38.5745880758361 3.33752750516215e-05 5.26957884574373 up 2 Molecular Function:fructose-bisphosphate aldolase activity (GO:0004332),Biological Process:glycolytic process (GO:0006096) fructose-bisphosphate aldolase, class I 4.1.2.13 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Fructose-biphosphate aldolase G Carbohydrate transport and metabolism ; IPR000741 [Fructose-bisphosphate aldolase, class-I] -- -- A0A8B9WUJ5 Aldehyde dehydrogenase 6 family member A1 ALDH6A1 121034789.105862 5770894.4375 20.9733153875355 0.000408643991736274 4.39048303047966 up 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00280 Valine, leucine and isoleucine degradation ko00410 beta-Alanine metabolism ko00562 Inositol phosphate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Methylmalonate semialdehyde dehydrogenase EG Amino acid transport and metabolism ; Carbohydrate transport and metabolism ; IPR015590 [Aldehyde dehydrogenase domain] mitochondrion protein -- A0A8B9W7F7 Voltage dependent anion channel 1 VDAC1 41723304.641279 9188636.375 4.54075043765991 0.0411097628028746 2.18293074756508 up 2 Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:transmembrane transport (GO:0055085) voltage-dependent anion channel protein 1 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04217 Necroptosis ko04218 Cellular senescence ko04621 NOD-like receptor signaling pathway ko04979 Cholesterol metabolism ko05012 Parkinson's disease ko05016 Huntington's disease ko05164 Influenza A ko05166 HTLV-I infection Porin/voltage-dependent anion-selective channel protein P Inorganic ion transport and metabolism ; IPR027246 [Eukaryotic porin/Tom40] plasma membrane protein -- A0A8B9YBW1 Cilia and flagella associated protein 69 CFAP69 3086347.27535882 9136263.5625 0.337812854702091 0.0399349448921027 -1.56570386721549 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9WY03 aldehyde dehydrogenase (NAD(+)) ALDH7A1 25265165.6051086 1959653.3125 12.8926710882737 0.00228960825731989 3.68847928539764 up 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00010 Glycolysis / Gluconeogenesis ko00053 Ascorbate and aldarate metabolism ko00071 Fatty acid degradation ko00260 Glycine, serine and threonine metabolism ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00561 Glycerolipid metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] cytoplasm protein -- A0A8C0A7K9 Solute carrier family 25 member 13 SLC25A13 52924120.5060453 881037.5625 60.070220338699 4.22802597587153e-06 5.90857805059402 up -- -- solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 -- -- Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] mitochondrion protein -- A0A8B9W5C4 Heterogeneous nuclear ribonucleoproteins A2/B1 64935878.9584966 2291110.71875 28.3425320422423 0.000124403605898667 4.82489674522546 up 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A2/B1 -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR021662 [Nuclear factor hnRNPA1] cytoplasm protein -- A0A8B9X0U6 Sodium/potassium-transporting ATPase subunit alpha ATP1A1 28820365.6216681 6050544 4.76326849646381 0.0368674410957831 2.2519518729932 up 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) sodium/potassium-transporting ATPase subunit alpha 3.6.3.9 ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04911 Insulin secretion ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04925 Aldosterone synthesis and secretion ko04960 Aldosterone-regulated sodium reabsorption ko04961 Endocrine and other factor-regulated calcium reabsorption ko04964 Proximal tubule bicarbonate reclamation ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04973 Carbohydrate digestion and absorption ko04974 Protein digestion and absorption ko04976 Bile secretion ko04978 Mineral absorption Na+/K+ ATPase, alpha subunit P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068 [Cation-transporting P-type ATPase, C-terminal] ; IPR008250 [P-type ATPase, A domain] nucleus protein -- A0A8B9XLE2 Myeloperoxidase MPO 10444776.1758475 30007872 0.348067872851747 0.0449387877890671 -1.52255943743728 down -- -- myeloperoxidase 1.11.2.2 ko04145 Phagosome ko05202 Transcriptional misregulation in cancer ko05221 Acute myeloid leukemia Peroxidase/oxygenase R General function prediction only ; IPR019791 [Haem peroxidase, animal] lysosome protein -- A0A8C0AKF8 Coiled-coil domain containing 81 CCDC81 33518906.2926372 97290496.625 0.344523951006579 0.0431724869801363 -1.53732381356213 down -- -- -- -- -- -- -- -- IPR028034 [Domain of unknown function DUF4496] -- -- A0A8B9YUB6 ITPRIP like 1 ITPRIPL1 5590632.34118552 17596182.4375 0.317718480189832 0.0310876120410835 -1.65417908760955 down -- -- -- -- -- -- -- -- IPR024810 [Mab-21 domain] -- -- A0A8B9X8J0 Armadillo repeat-containing domain-containing protein 4064182.50531882 15282394.625 0.265938853500769 0.0140965259206799 -1.91083352544668 down -- -- -- -- -- -- -- -- IPR006911 [Armadillo repeat-containing domain] endoplasmic reticulum protein -- A0A8B9Y0V6 Leucine rich repeats and death domain containing 1 LRRD1 5600943.35586527 18463351.8125 0.303354635319971 0.0255437979043149 -1.7209227386771 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] cytoplasm protein -- A0A8B9Y5M3 Semaphorin-3C SEMA3C 5528115.76206211 22158581.375 0.249479678708092 0.0103629913628213 -2.00300578882803 down 1 Molecular Function:protein binding (GO:0005515) semaphorin 3 -- ko04360 Axon guidance Semaphorins T Signal transduction mechanisms ; IPR001627 [Sema domain] ; IPR013098 [Immunoglobulin I-set] extracell protein -- A0A8B9YQU6 Filamin B FLNB 14995660.9641724 2394214.4375 6.26329067659897 0.0189414875982915 2.64692083534642 up 1 Molecular Function:protein binding (GO:0005515) filamin -- ko04010 MAPK signaling pathway ko04510 Focal adhesion ko05132 Salmonella infection ko05205 Proteoglycans in cancer Actin-binding cytoskeleton protein, filamin Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR017868 [Filamin/ABP280 repeat-like] cytoplasm protein -- A0A8B9YGX3 Small ribosomal subunit protein uS3 RPS3 82403465.8079935 627880.640625 131.240653838233 6.63613295825652e-08 7.03607087623856 up 1 Molecular Function:RNA binding (GO:0003723) small subunit ribosomal protein S3e -- ko03010 Ribosome 40S ribosomal protein S3 J Translation, ribosomal structure and biogenesis ; IPR004044 [K Homology domain, type 2] -- -- A0A8C0AIG4 Dynein regulatory complex subunit 4 GAS8 26487628.1529002 97159619.671875 0.272619718380471 0.015831942665137 -1.8750381799163 down 2 Cellular Component:motile cilium (GO:0031514),Biological Process:cell motility (GO:0048870) growth arrest-specific protein 8 -- -- -- -- -- IPR025593 [Growth arrest-specific protein 8] -- -- A0A8B9YEB5 ADP/ATP translocase SLC25A5 15500649.7253687 1322921 11.7169881840024 0.00312192761183714 3.55052987195065 up -- -- solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04217 Necroptosis ko04218 Cellular senescence ko05012 Parkinson's disease ko05016 Huntington's disease ko05166 HTLV-I infection Mitochondrial ADP/ATP carrier proteins C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] mitochondrion protein -- A0A8B9YSS9 Solute carrier family 25 member 10 SLC25A10 10784012.7537124 39711053.125 0.271561993578139 0.0155484977760132 -1.88064651336488 down -- -- solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10 -- ko04964 Proximal tubule bicarbonate reclamation Mitochondrial oxoglutarate/malate carrier proteins C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] mitochondrion protein -- A0A8B9WNJ9 Proteasome subunit beta PSMB5 32706517.6113236 284809475.25 0.114836480010416 8.83543373298901e-05 -3.12234708031415 down 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 5 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] nucleus protein -- A0A8B9XFR8 Cilia- and flagella-associated protein 43 5130545.25469995 15490882.625 0.33119773604249 0.036881875897778 -1.59423528379963 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9WS97 Spermatogenesis-associated protein 20 SPATA20 6991697.45233558 19630191.125 0.356170625533611 0.04912321074389 -1.48935955695563 down -- -- -- -- -- Highly conserved protein containing a thioredoxin domain R General function prediction only ; IPR004879 [Domain of unknown function DUF255] -- -- A0A8B9YK86 Proteasome subunit alpha type PSMA7 9750657.12170743 817486.125 11.9276117643066 0.00294875551054054 3.57623329963804 up 5 Molecular Function:endopeptidase activity (GO:0004175),Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit alpha 4 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit alpha type PSMA7/PRE6 O Posttranslational modification, protein turnover, chaperones ; IPR000426 [Proteasome alpha-subunit, N-terminal domain] ; IPR001353 [Proteasome, subunit alpha/beta] nucleus protein -- A0A8B9X3K5 Solute carrier family 25 member 12 SLC25A12 11692244.9223781 37163894.125 0.314613018836279 0.0298339757598536 -1.66834972349192 down -- -- solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 -- -- Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] mitochondrion protein -- A0A8B9W175 Cilia and flagella associated protein 65 CFAP65 2564415.22681827 9078913.4375 0.282458384967752 0.0186277362222295 -1.8238897662026 down -- -- -- -- -- -- -- -- -- -- -- A0A8C0A4P3 Nucleoporin 205 NUP205 762705.598715034 6508299.5625 0.117189688549317 0.000102569396157649 -3.09308246141749 down 1 Cellular Component:nuclear pore (GO:0005643) nuclear pore complex protein Nup205 -- ko03013 RNA transport Uncharacterized conserved protein S Function unknown ; IPR021827 [Nucleoporin Nup186/Nup192/Nup205] -- -- A0A8C0A472 Non-lysosomal glucosylceramidase GBA2 2157227.16217037 6251662.5 0.345064558774625 0.0434394032814906 -1.53506179122637 down -- -- non-lysosomal glucosylceramidase 3.2.1.45 ko00511 Other glycan degradation ko00600 Sphingolipid metabolism ko01100 Metabolic pathways Predicted bile acid beta-glucosidase G Carbohydrate transport and metabolism ; IPR006775 [Glycosyl-hydrolase family 116, catalytic region] ; IPR024462 [Glycosyl-hydrolase family 116, N-terminal] plasma membrane protein -- A0A8B9WAM8 EF-hand domain-containing protein 3439769.11221864 17507346.5 0.196475754462199 0.00293129013256522 -2.34757680314291 down 2 Molecular Function:calcium ion binding (GO:0005509),Biological Process:metabolic process (GO:0008152) -- -- ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko01100 Metabolic pathways Predicted phosphate acyltransferase, contains PlsC domain I Lipid transport and metabolism ; IPR002048 [EF-hand domain] ; IPR002123 [Phospholipid/glycerol acyltransferase] endoplasmic reticulum protein -- A0A8B9WAY2 IF rod domain-containing protein 7809672.01878248 902227.8125 8.6559867813679 0.00783917399845097 3.11369829601437 up 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444 [Keratin type II head] cytoplasm protein -- A0A8B9XN66 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 11121861.1613494 1435108.125 7.74984195797052 0.0107227600696583 2.95416688989952 up -- -- 14-3-3 protein beta/theta/zeta -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko05161 Hepatitis B ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] cytoplasm protein -- A0A8B9WIG2 Poly(rC) binding protein 1 PCBP1 14123491.004293 1024754.09375 13.7823221106727 0.00183394213320298 3.78474707547789 up 1 Molecular Function:RNA binding (GO:0003723) poly(rC)-binding protein 1 -- ko03040 Spliceosome ko04216 Ferroptosis PolyC-binding proteins alphaCP-1 and related KH domain proteins AR RNA processing and modification ; General function prediction only ; IPR004088 [K Homology domain, type 1] cytoplasm protein -- A0A8C0AHV2 Peroxiredoxin-6 PRDX6 150252773.417811 6321017.125 23.7703474688515 0.000252110118829403 4.57109108726847 up 4 Molecular Function:antioxidant activity (GO:0016209),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:peroxiredoxin activity (GO:0051920),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko01100 Metabolic pathways Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes O Posttranslational modification, protein turnover, chaperones ; IPR000866 [Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant] ; IPR019479 [Peroxiredoxin, C-terminal] cytoplasm protein -- A0A8B9WVT6 1-acylglycerol-3-phosphate O-acyltransferase 5 AGPAT5 5416044.60976815 15729101 0.344332750471127 0.0430783026794112 -1.53812468860858 down 1 Biological Process:metabolic process (GO:0008152) lysophosphatidiate acyltransferase 2.3.1.51 ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04072 Phospholipase D signaling pathway Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] ; IPR032098 [Acyltransferase, C-terminal domain] endoplasmic reticulum protein -- A0A8B9YIR8 Translation elongation factor IF5A C-terminal domain-containing protein 24219191.5031342 1901858.5625 12.7344861393362 0.00238437669101336 3.67066884019335 up 6 Molecular Function:RNA binding (GO:0003723),Molecular Function:translation elongation factor activity (GO:0003746),Biological Process:translational frameshifting (GO:0006452),Molecular Function:ribosome binding (GO:0043022),Biological Process:positive regulation of translational elongation (GO:0045901),Biological Process:positive regulation of translational termination (GO:0045905) translation initiation factor 5A -- -- Translation initiation factor 5A (eIF-5A) J Translation, ribosomal structure and biogenesis ; IPR020189 [Translation elongation factor, IF5A C-terminal] nucleus protein -- A0A8B9Y2D9 non-specific serine/threonine protein kinase CSNK1G2 10322620.9188173 32716843.875 0.315513958444664 0.0301945401272886 -1.66422426294915 down 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) casein kinase 1, gamma 2.7.11.1 ko04340 Hedgehog signaling pathway Casein kinase (serine/threonine/tyrosine protein kinase) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR022247 [Casein kinase 1 gamma C-terminal] cytoplasm protein -- A0A8B9YLX4 Methylmalonyl-CoA mutase, mitochondrial MMUT 12574661.5231729 2237948.3125 5.61883464999503 0.0248842608433784 2.49027094556957 up 4 Biological Process:metabolic process (GO:0008152),Molecular Function:intramolecular transferase activity (GO:0016866),Molecular Function:cobalamin binding (GO:0031419),Molecular Function:metal ion binding (GO:0046872) methylmalonyl-CoA mutase 5.4.99.2 ko00280 Valine, leucine and isoleucine degradation ko00630 Glyoxylate and dicarboxylate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism -- -- -- IPR006099 [Methylmalonyl-CoA mutase, alpha/beta chain, catalytic] ; IPR006158 [Cobalamin (vitamin B12)-binding domain] mitochondrion protein -- A0A8B9WH08 Carnitine palmitoyltransferase 2 CPT2 46530860.7454121 3674722.1875 12.6624159245813 0.00242912457023812 3.66248078479493 up -- -- carnitine O-palmitoyltransferase 2 2.3.1.21 ko00071 Fatty acid degradation ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway Carnitine O-acyltransferase CPT2/YAT1 I Lipid transport and metabolism ; IPR000542 [Acyltransferase ChoActase/COT/CPT] mitochondrion protein -- A0A8C0A2Z1 Aspartate--tRNA ligase, cytoplasmic DARS1 12607216.0328108 384054.375 32.8266434481076 6.72902804111111e-05 5.03679533555868 up 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) Aspartyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR004364 [Aminoacyl-tRNA synthetase, class II (D/K/N)] cytoplasm protein -- A0A8B9X7X6 Centrosomal protein of 44 kDa CEP44 656063.25004515 2018972.375 0.324949096960849 0.0341245007023278 -1.62171435617341 down -- -- centrosomal protein CEP44 -- -- -- -- -- IPR029157 [Centrosomal CEP44 domain] -- -- A0A8B9XBZ5 Ubiquitin specific peptidase 50 USP50 2151723.76809839 7695356.5 0.279613266532667 0.0177894776803569 -1.83849528243284 down 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) -- -- -- Ubiquitin C-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] nucleus protein -- A0A8B9XW77 [tau protein] kinase GSK3A 2099888.8614696 9140513.8125 0.229734225509065 0.00683767436993524 -2.12196229131058 down 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) glycogen synthase kinase 3 alpha 2.7.11.26 ko04062 Chemokine signaling pathway ko04728 Dopaminergic synapse ko04932 Non-alcoholic fatty liver disease (NAFLD) Glycogen synthase kinase-3 G Carbohydrate transport and metabolism ; IPR000719 [Protein kinase domain] mitochondrion protein -- A0A8B9XXV2 Dynein regulatory complex protein 10 IQCD 1961423.62160037 9249426.75 0.212058938852656 0.00447467350030229 -2.23746279720841 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR000048 [IQ motif, EF-hand binding site] -- -- A0A8B9VZ67 Heterogeneous nuclear ribonucleoprotein A3 HNRNPA3 21497334.4559175 1033639.4375 20.7977111514938 0.000421870628702918 4.37835285921113 up 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A1/A3 -- ko03040 Spliceosome FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] cytoplasm protein -- A0A8C0A8B4 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma YWHAG 17656651.1669082 932548.625 18.933759263125 0.00059911300027972 4.24288897881974 up -- -- 14-3-3 protein gamma/eta -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] cytoplasm protein -- A0A8B9YPS9 40S ribosomal protein S4 37306013.3798429 8861189 4.21004600848068 0.0486143996562901 2.07383599952545 up 1 Molecular Function:RNA binding (GO:0003723) small subunit ribosomal protein S4e -- ko03010 Ribosome 40S ribosomal protein S4 J Translation, ribosomal structure and biogenesis ; IPR002942 [RNA-binding S4 domain] ; IPR005824 [KOW] ; IPR013843 [Ribosomal protein S4e, N-terminal] ; IPR013845 [Ribosomal protein S4e, central region] ; IPR032277 [40S ribosomal protein S4, C-terminal domain] -- -- A0A8B9XX63 Testis specific serine kinase 4 TSSK4 13171918.7983093 55096490.125 0.239070016409857 0.00838089869743022 -2.06449489285664 down 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) testis-specific serine kinase 2.7.11.1 -- Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] nucleus protein -- A0A8B9XLM0 Zinc finger MYND-type containing 12 ZMYND12 4700097.50305725 17845383.5625 0.263378900576503 0.0134658058941252 -1.92478831972914 down -- -- -- -- -- -- -- -- IPR002893 [Zinc finger, MYND-type] -- -- A0A8B9WI26 Large ribosomal subunit protein uL11 21403629.0260475 1065569.875 20.0865560562582 0.00048093478846727 4.32815832264817 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L12e -- ko03010 Ribosome 40S ribosomal protein S2 J Translation, ribosomal structure and biogenesis ; IPR020783 [Ribosomal protein L11, C-terminal] ; IPR020784 [Ribosomal protein L11, N-terminal] -- -- A0A8B9Y6H9 SPEM family member 2 SPEM2 2515160.55227101 9514220.125 0.264358036625835 0.0137048254655109 -1.91943490880025 down -- -- -- -- -- -- -- -- IPR031368 [Spermatid maturation protein 1, N-terminal] -- -- A0A8B9XMN3 RNA-splicing ligase RtcB homolog RTCB 17909647.2472747 1242273.625 14.4168296636538 0.00157492463737417 3.84968203814902 up 2 Biological Process:RNA processing (GO:0006396),Molecular Function:RNA ligase activity (GO:0008452) tRNA-splicing ligase RtcB 6.5.1.3 -- Uncharacterized conserved protein, contains RtcB domain S Function unknown ; IPR001233 [tRNA-splicing ligase, RtcB] -- -- A0A8B9X240 Aspartylglucosaminidase AGA 20476829.2472308 4894876.5 4.18331887377154 0.0492934789132022 2.06464797170302 up 1 Molecular Function:hydrolase activity (GO:0016787) N4-(beta-N-acetylglucosaminyl)-L-asparaginase 3.5.1.26 ko00511 Other glycan degradation ko04142 Lysosome Asparaginase E Amino acid transport and metabolism ; IPR000246 [Peptidase T2, asparaginase 2] lysosome protein -- A0A8B9WWB4 Calcium-transporting ATPase ATP2B4 2577663.62459247 7819380.375 0.32965062459856 0.0361877049398524 -1.60099028000905 down 3 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:calcium-transporting ATPase activity (GO:0005388),Molecular Function:metal ion binding (GO:0046872) Ca2+ transporting ATPase, plasma membrane 3.6.3.8 ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04925 Aldosterone synthesis and secretion ko04970 Salivary secretion ko04972 Pancreatic secretion Calcium transporting ATPase P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068 [Cation-transporting P-type ATPase, C-terminal] ; IPR008250 [P-type ATPase, A domain] ; IPR022141 [Plasma membrane calcium transporting P-type ATPase, C-terminal] ; IPR023214 [HAD-like domain] nucleus protein -- A0A8B9YH44 Glutamate--cysteine ligase GCLC 15270250.9575639 501432 30.4532837105807 9.2372378654383e-05 4.92852589403867 up 2 Molecular Function:glutamate-cysteine ligase activity (GO:0004357),Biological Process:glutathione biosynthetic process (GO:0006750) glutamate--cysteine ligase catalytic subunit 6.3.2.2 ko00270 Cysteine and methionine metabolism ko00480 Glutathione metabolism ko01100 Metabolic pathways ko04216 Ferroptosis Gamma-glutamylcysteine synthetase H Coenzyme transport and metabolism ; IPR004308 [Glutamate-cysteine ligase catalytic subunit] -- -- A0A8B9YNG5 urocanate hydratase UROC1 26103163.3560712 2248789.5 11.6076508521901 0.00321668436343139 3.53700412507407 up 1 Molecular Function:urocanate hydratase activity (GO:0016153) urocanate hydratase 4.2.1.49 ko00340 Histidine metabolism ko01100 Metabolic pathways -- -- -- IPR023637 [Urocanase] -- -- A0A8B9XM77 E1 ubiquitin-activating enzyme UBA1 8369694.41766135 1283804.5625 6.51944592046217 0.0170762889159559 2.70474935682305 up 1 Molecular Function:small protein activating enzyme activity (GO:0008641) ubiquitin-activating enzyme E1 6.2.1.45 ko04120 Ubiquitin mediated proteolysis ko05012 Parkinson's disease Ubiquitin activating enzyme UBA1 O Posttranslational modification, protein turnover, chaperones ; IPR000594 [THIF-type NAD/FAD binding fold] ; IPR018965 [Ubiquitin-activating enzyme E1, C-terminal] ; IPR019572 [Ubiquitin-activating enzyme, catalytic cysteine domain] ; IPR032418 [Ubiquitin-activating enzyme E1, FCCH domain] ; IPR032420 [Ubiquitin-activating enzyme E1, four-helix bundle] nucleus protein -- A0A8B9W801 Proliferation-associated 2G4 PA2G4 14696022.5199948 2185606.625 6.7240016350128 0.0157479713130531 2.74932007538083 up -- -- -- -- -- Metallopeptidase R General function prediction only ; IPR000994 [Peptidase M24] nucleus protein -- A0A8B9WG93 Propionyl-CoA carboxylase subunit beta PCCB 7923592.62889447 1096163.3125 7.22847821901946 0.0129796900444615 2.85369195465097 up -- -- propionyl-CoA carboxylase beta chain 6.4.1.3 ko00280 Valine, leucine and isoleucine degradation ko00630 Glyoxylate and dicarboxylate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism 3-Methylcrotonyl-CoA carboxylase, non-biotin containing subunit/Acetyl-CoA carboxylase carboxyl transferase, subunit beta EI Amino acid transport and metabolism ; Lipid transport and metabolism ; IPR000022 [Carboxyl transferase] mitochondrion protein -- A0A8B9YGR5 AP complex subunit beta AP2B1 3434221.79939482 728518.9375 4.71397738977076 0.0377580125268923 2.2369448388291 up 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:clathrin adaptor complex (GO:0030131) AP-2 complex subunit beta-1 -- ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease Vesicle coat complex AP-1/AP-2/AP-4, beta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR008152 [Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain] ; IPR015151 [Beta-adaptin appendage, C-terminal subdomain] plasma membrane protein -- A0A8B9XC60 NADH-cytochrome b5 reductase 45581125.5510748 1154344.6875 39.4865814731571 3.00840577718202e-05 5.30329056764371 up 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) cytochrome-b5 reductase 1.6.2.2 ko00520 Amino sugar and nucleotide sugar metabolism NADH-cytochrome b-5 reductase HC Coenzyme transport and metabolism ; Energy production and conversion ; IPR001433 [Oxidoreductase FAD/NAD(P)-binding] ; IPR008333 [Oxidoreductase, FAD-binding domain] mitochondrion protein -- A0A8C0A8M3 Polyadenylate-binding protein PABPC1 16491173.8165159 1819660.15625 9.06277678272701 0.00685818782071515 3.17995315147369 up 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723) polyadenylate-binding protein -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03018 RNA degradation Polyadenylate-binding protein (RRM superfamily) AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] ; IPR002004 [Polyadenylate-binding protein/Hyperplastic disc protein] cytoplasm protein -- A0A8C0ADH0 Ribosomal protein 24458882.6909299 1295481.375 18.8801500067339 0.000605406356517467 4.23879832214598 up -- -- large subunit ribosomal protein L10Ae -- ko03010 Ribosome 60S ribosomal protein L10A J Translation, ribosomal structure and biogenesis ; IPR028364 [Ribosomal protein L1/ribosomal biogenesis protein] -- -- A0A8B9WQD8 Glycogen debranching enzyme AGL 12530659.6958506 1326996.25 9.4428749861581 0.00607416158443244 3.23922617068863 up -- -- -- -- ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways Alpha amylase G Carbohydrate transport and metabolism ; IPR029436 [Eukaryotic glycogen debranching enzyme, N-terminal domain] ; IPR032788 [Glycogen debranching enzyme, central domain] ; IPR032790 [Glycogen debranching enzyme, C-terminal] ; IPR032792 [Glycogen debranching enzyme, glucanotransferase domain] -- -- A0A8B9XER8 Serine protease 50 PRSS50 49349681.1323932 150417041.25 0.328085705730455 0.0354932189423821 -1.60785535601738 down 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) -- -- -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] endoplasmic reticulum protein -- A0A8B9YWJ9 Small ribosomal subunit protein uS5 RPS2 34197309.6632237 7550785.125 4.52897402019816 0.0413509204660534 2.17918426360114 up 4 Molecular Function:RNA binding (GO:0003723),Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S2e -- ko03010 Ribosome 40S ribosomal protein S2/30S ribosomal protein S5 J Translation, ribosomal structure and biogenesis ; IPR005324 [Ribosomal protein S5, C-terminal] ; IPR013810 [Ribosomal protein S5, N-terminal] -- -- A0A8B9Y7A7 Haptoglobin 18204051.4593709 3298674.1875 5.51859638892297 0.0260068200196438 2.46430137565608 up 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) haptoglobin -- -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] extracell protein -- A0A8B9WEB1 Glutathione S-transferase 63474247.1395896 4012696.875 15.8183508789434 0.00114316917699473 3.98352729629194 up 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046 [Glutathione S-transferase, C-terminal] cytoplasm protein -- A0A8B9X298 Proteasome 20S subunit alpha 2 11919135.4715422 92033153.375 0.129509150066566 0.000209800666707143 -2.94887406423948 down 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit alpha 2 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit alpha type PSMA2/PRE8 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] nucleus protein -- A0A8B9YDY1 Aldehyde dehydrogenase domain-containing protein 125655221.802707 8410067.5 14.9410479526718 0.00139362250369251 3.90120943599314 up 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) retinal dehydrogenase 1.2.1.36 ko00830 Retinol metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] cytoplasm protein -- A0A8B9XS63 Proteasome activator subunit 4 PSME4 4982752.05290266 111868000.25 0.0445413526814399 1.85007952634147e-08 -4.48871081761282 down -- -- proteasome activator subunit 4 -- ko03050 Proteasome Uncharacterized conserved protein S Function unknown ; IPR021843 [Protein of unknown function DUF3437] ; IPR032430 [Proteasome activator Blm10, mid region] nucleus protein -- A0A8B9X5T7 Elongation factor Tu TUFM 46979493.4144842 262821.96875 178.750253024593 1.07233838955786e-08 7.48180147383116 up 1 Molecular Function:GTP binding (GO:0005525) elongation factor Tu -- -- Mitochondrial translation elongation factor Tu J Translation, ribosomal structure and biogenesis ; IPR004160 [Translation elongation factor EFTu/EF1A, C-terminal] ; IPR004161 [Translation elongation factor EFTu-like, domain 2] mitochondrion protein -- A0A8B9WUL1 IQ motif containing with AAA domain 1 like IQCA1L 610690.69878082 6151507.5 0.0992749661413597 2.91088075689157e-05 -3.33242622606931 down 2 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524) -- -- -- -- -- -- IPR000048 [IQ motif, EF-hand binding site] ; IPR003959 [ATPase, AAA-type, core] centrosome protein -- A0A8C0A7Y3 AU RNA binding protein/enoyl-CoA hydratase 12768683.6161359 2249993.25 5.67498752102296 0.0242817478864199 2.50461722000213 up 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) methylglutaconyl-CoA hydratase 4.2.1.18 ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways Enoyl-CoA hydratase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] -- -- A0A8B9XXK8 Peptidyl-prolyl cis-trans isomerase 97092366.9532457 17280658.75 5.61855704449031 0.0248872854667064 2.49019966566834 up 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl cis-trans isomerase A (cyclophilin A) 5.2.1.8 ko04217 Necroptosis Cyclophilin type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] mitochondrion protein -- A0A8B9YB54 Nipsnap homolog 1 NIPSNAP1 37213573.1736703 926376.6875 40.1711028308561 2.78620762699103e-05 5.32808616360873 up -- -- -- -- -- NIPSNAP1 protein S Function unknown ; IPR012577 [NIPSNAP] -- -- A0A8B9W7C3 Methanethiol oxidase SELENBP1 39760635.0604904 1903513 20.8880291652804 0.000415005120704108 4.38460447204065 up 1 Molecular Function:selenium binding (GO:0008430) selenium-binding protein 1 -- -- Selenium-binding protein P Inorganic ion transport and metabolism ; IPR008826 [Selenium-binding protein] -- -- A0A8B9WJT3 Serine hydroxymethyltransferase SHMT2 12189808.0594597 620489.1875 19.6454802195239 0.00052253764408089 4.29612552874952 up 1 Molecular Function:transferase activity (GO:0016740) glycine hydroxymethyltransferase 2.1.2.1 ko00260 Glycine, serine and threonine metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko00670 One carbon pool by folate ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko01523 Antifolate resistance Glycine/serine hydroxymethyltransferase E Amino acid transport and metabolism ; IPR001085 [Serine hydroxymethyltransferase] mitochondrion protein -- A0A8B9X4V1 Regucalcin RGN 87322142.9777896 1251851 69.7544220340836 2.00889358740819e-06 6.12421277339796 up -- -- gluconolactonase 3.1.1.17 ko00030 Pentose phosphate pathway ko00053 Ascorbate and aldarate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Ca2+-binding protein Regucalcin/SMP30 PT Inorganic ion transport and metabolism ; Signal transduction mechanisms ; IPR013658 [SMP-30/Gluconolactonase/LRE-like region] -- -- A0A8B9X745 Malate dehydrogenase MDH1 110015221.449285 14872899.125 7.39702599504352 0.012191032208344 2.8869453457943 up 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) malate dehydrogenase 1.1.1.37 ko00020 Citrate cycle (TCA cycle) ko00270 Cysteine and methionine metabolism ko00620 Pyruvate metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04964 Proximal tubule bicarbonate reclamation Malate dehydrogenase C Energy production and conversion ; IPR001236 [Lactate/malate dehydrogenase, N-terminal] ; IPR022383 [Lactate/malate dehydrogenase, C-terminal] cytoplasm protein -- A0A8B9YVB4 Large ribosomal subunit protein uL4 17870328.6004891 710410.25 25.1549419514838 0.00020155903001113 4.65276995529579 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L4e -- ko03010 Ribosome Ribosomal protein RPL1/RPL2/RL4L4 A RNA processing and modification ; IPR002136 [Ribosomal protein L4/L1e] ; IPR025755 [60S ribosomal protein L4, C-terminal domain] -- -- A0A8B9W4X6 Ribosomal protein L5 eukaryotic C-terminal domain-containing protein 24099596.9106391 1138624.59375 21.165533436502 0.000394728241806815 4.40364494435154 up 5 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412),Molecular Function:5S rRNA binding (GO:0008097) large subunit ribosomal protein L5e -- ko03010 Ribosome 60S ribosomal protein L5 J Translation, ribosomal structure and biogenesis ; IPR005485 [Ribosomal protein L5 eukaryotic/L18 archaeal] ; IPR025607 [Ribosomal protein L5 eukaryotic/L18 archaeal, C-terminal] nucleus protein -- A0A8B9X841 Probable ATP-dependent RNA helicase DDX5 DDX5 8725689.12712726 611758.6875 14.2632860070782 0.00163332420769411 3.83423448620541 up 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX5/DBP2 3.6.4.13 ko03040 Spliceosome ko05202 Transcriptional misregulation in cancer ko05205 Proteoglycans in cancer ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545 [DEAD/DEAH box helicase domain] ; IPR012587 [RNA helicase p68 repeat] nucleus protein -- A0A8B9YLK3 Argininosuccinate lyase ASL 37958635.815384 1292588.875 29.3663643170254 0.000107461442942203 4.87609275971688 up -- -- argininosuccinate lyase 4.3.2.1 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Argininosuccinate lyase E Amino acid transport and metabolism ; IPR022761 [Fumarate lyase, N-terminal] ; IPR029419 [Argininosuccinate lyase, C-terminal] -- -- A0A8B9W5I6 Keratin 18 KRT18 47031891.1478183 3070892.75 15.315380567367 0.00127941636675252 3.93690931137249 up 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] cytoskeleton protein -- A0A8B9X8Y2 NSFL1 cofactor p47 NSFL1C 8299346.4042906 296787.21875 27.9639616532193 0.00013145469291124 4.80549685662288 up 1 Molecular Function:protein binding (GO:0005515) UBX domain-containing protein 1 -- ko04141 Protein processing in endoplasmic reticulum Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion Y Nuclear structure ; IPR001012 [UBX domain] ; IPR012989 [SEP domain] -- -- A0A8C0AIX5 Cilia- and flagella-associated protein 206 CFAP206 3623275.12088396 12899433.125 0.280886383593229 0.0181615601818513 -1.83194140562654 down -- -- -- -- -- -- -- -- IPR021897 [Cilia- and flagella-associated protein 206] -- -- A0A8B9X6Y0 mRNA export factor 2390648.44488378 9637820.5 0.248048658395721 0.0100735962249282 -2.01130494064437 down 1 Molecular Function:protein binding (GO:0005515) mRNA export factor -- ko03013 RNA transport ko05164 Influenza A mRNA export protein (contains WD40 repeats) A RNA processing and modification ; IPR001680 [WD40 repeat] nucleus protein -- A0A8C0A6K9 T-complex-associated-testis-expressed 1 TCTE1 4538921.83116006 116721553.25 0.0388867497456821 4.30423234808511e-09 -4.68457753411665 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] cytoplasm protein -- A0A8B9WFC7 Endophilin-B1 SH3GLB1 6317988.6045361 26875399.25 0.235084455704825 0.00769574723381863 -2.08874894687458 down 2 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737) endophilin-B1 -- ko04140 Autophagy - animal ko04144 Endocytosis SH3 domain protein SH3GLB T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR004148 [BAR domain] -- -- A0A8B9X9Y9 Keratin 14 KRT14 1023360.77173096 5104933.75 0.20046504457202 0.00328255624090044 -2.31857740144471 down 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] cytoskeleton protein -- A0A8C0AKY7 Glutamine rich 2 1338815.42123813 4197288 0.318971540966007 0.0316020767906434 -1.64850038418488 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9XIW2 Small ribosomal subunit protein eS1 RPS3A 33792052.0972055 5728938.9375 5.89848355268938 0.0220562998029242 2.56034409816619 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S3Ae -- ko03010 Ribosome 40S ribosomal protein S3A J Translation, ribosomal structure and biogenesis ; IPR001593 [Ribosomal protein S3Ae] -- -- A0A8B9WM11 HIT domain-containing protein 5112511.98575523 784033.5 6.52078257594252 0.0170671683175555 2.70504511640121 up -- -- histidine triad (HIT) family protein -- -- Zinc-binding protein of the histidine triad (HIT) family T Signal transduction mechanisms ; IPR001310 [Histidine triad (HIT) protein] nucleus protein -- A0A8B9WAC0 Aldo-keto reductase family 1 member A1 AKR1A1 50027795.2323047 413657.28125 120.940202191363 1.05655075445071e-07 6.91815008581856 up -- -- alcohol dehydrogenase (NADP+) 1.1.1.2 ko00010 Glycolysis / Gluconeogenesis ko00040 Pentose and glucuronate interconversions ko00561 Glycerolipid metabolism ko01100 Metabolic pathways Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] cytoplasm protein -- A0A8B9WYQ5 Peptidase S1 domain-containing protein 2398815.60108327 7075552.1875 0.339028748218567 0.0405110625398635 -1.56052048183883 down 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) granzyme M 3.4.21.- -- -- -- -- IPR001254 [Serine proteases, trypsin domain] -- -- A0A8B9XNI2 Vesicle-trafficking protein SEC22b SEC22B 5259340.87981762 1165046.125 4.51427696033719 0.0416543826325799 2.17449493360452 up 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:vesicle-mediated transport (GO:0016192) vesicle transport protein SEC22 -- ko04130 SNARE interactions in vesicular transport ko04145 Phagosome ko05134 Legionellosis Synaptobrevin/VAMP-like protein SEC22 U Intracellular trafficking, secretion, and vesicular transport ; IPR001388 [Synaptobrevin] ; IPR010908 [Longin domain] endoplasmic reticulum protein -- A0A8C0AJB7 Sialic acid acetylesterase SIAE 7413436.82329835 798758.875 9.28119493294938 0.00639349814532986 3.21431056104895 up -- -- sialate O-acetylesterase 3.1.1.53 -- -- -- -- IPR005181 [Sialate O-acetylesterase domain] -- -- A0A8B9YMN3 RBR-type E3 ubiquitin transferase ARIH2 635941.015648579 3228880.25 0.196954041776117 0.00297189737134408 -2.34406907148438 down -- -- ariadne-2 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR002867 [IBR domain] nucleus protein -- A0A8B9XF90 Dynein regulatory complex protein 9 IQCG 2170619.78401724 16698524.375 0.129988718480236 0.000215292604817426 -2.94354167547111 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR000048 [IQ motif, EF-hand binding site] -- -- A0A8B9WZT0 Peroxiredoxin 4 PRDX4 8339159.43466013 1655430.5 5.03745668251257 0.0323661029554206 2.33269552784547 up 4 Molecular Function:antioxidant activity (GO:0016209),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:peroxiredoxin activity (GO:0051920),Biological Process:oxidation-reduction process (GO:0055114) peroxiredoxin (alkyl hydroperoxide reductase subunit C) 1.11.1.15 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes O Posttranslational modification, protein turnover, chaperones ; IPR000866 [Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant] ; IPR019479 [Peroxiredoxin, C-terminal] cytoplasm protein -- A0A8B9XX04 Letm1 RBD domain-containing protein 498567.359147944 4919281.375 0.101349632424298 3.42253339225685e-05 -3.30258723845161 down -- -- -- -- -- Ca2+-binding transmembrane protein LETM1/MRS7 S Function unknown ; IPR011685 [LETM1-like] mitochondrion protein -- A0A8B9WEI9 Multifunctional fusion protein ALDH4A1 41376995.2612093 6104816.46875 6.77776235747862 0.0154202972042416 2.76080905380369 up 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) 1-pyrroline-5-carboxylate dehydrogenase 1.2.1.88 ko00250 Alanine, aspartate and glutamate metabolism ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Delta-1-pyrroline-5-carboxylate dehydrogenase E Amino acid transport and metabolism ; IPR015590 [Aldehyde dehydrogenase domain] mitochondrion protein -- A0A8B9YXG8 Inositol-3-phosphate synthase 1 ISYNA1 5754287.93984337 29293194.75 0.196437704693967 0.00292807701979267 -2.34785622453114 down 3 Molecular Function:inositol-3-phosphate synthase activity (GO:0004512),Biological Process:inositol biosynthetic process (GO:0006021),Biological Process:phospholipid biosynthetic process (GO:0008654) myo-inositol-1-phosphate synthase 5.5.1.4 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways Myo-inositol-1-phosphate synthase I Lipid transport and metabolism ; IPR002587 [Myo-inositol-1-phosphate synthase] ; IPR013021 [Myo-inositol-1-phosphate synthase, GAPDH-like] -- -- A0A8B9W9I6 Testis expressed 55 9062586.77712232 26712855 0.339259385682374 0.0406208663695976 -1.5595393662289 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9WMZ5 3(2), 5-bisphosphate nucleotidase 1 BPNT1 5680446.94627516 1309201.875 4.33886251978914 0.0455015958123199 2.11731687397196 up 1 Biological Process:phosphatidylinositol phosphorylation (GO:0046854) 3'(2'), 5'-bisphosphate nucleotidase 3.1.3.7 ko00920 Sulfur metabolism ko01100 Metabolic pathways Bisphosphate 3'-nucleotidase BPNT1/Inositol polyphosphate 1-phosphatase F Nucleotide transport and metabolism ; IPR000760 [Inositol monophosphatase-like] cytoplasm protein -- A0A8B9W6C4 Centrosomal protein of 70 kDa CEP70 2775840.66092129 8032725.78125 0.345566466043278 0.0436880261332865 -1.53296487050046 down -- -- centrosomal protein CEP70 -- -- -- -- -- -- centrosome protein -- A0A8B9WB31 Ribosomal protein L3 32826978.4573663 5077759.1875 6.46485531219696 0.0174539982246984 2.69261808191306 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L3e -- ko03010 Ribosome 60S ribosomal protein L3 and related proteins J Translation, ribosomal structure and biogenesis ; IPR000597 [Ribosomal protein L3] cytoplasm protein -- A0A8B9Y565 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 2910034.11492973 10664412.6875 0.272873359293442 0.0159004019621663 -1.8736965441425 down 2 Cellular Component:mitochondrion (GO:0005739),Cellular Component:mitochondrial respiratory chain complex I (GO:0005747) NADH dehydrogenase (ubiquinone) flavoprotein 3 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR026193 [NADH-ubiquinone oxidoreductase flavoprotein 3] mitochondrion protein -- A0A8C0AD27 Proteasome 26S subunit, non-ATPase 14 PSMD14 136234786.164759 9234749.75 14.7524069252401 0.00145581427663793 3.88287845111222 up 1 Molecular Function:protein binding (GO:0005515) 26S proteasome regulatory subunit N11 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN11 O Posttranslational modification, protein turnover, chaperones ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] ; IPR024969 [Rpn11/EIF3F, C-terminal] nucleus protein -- A0A8B9WKF9 Arylsulfatase A ARSA 30288165.9364152 3099673.6875 9.77140466706472 0.0054832188482126 3.28856596859524 up 2 Biological Process:metabolic process (GO:0008152),Molecular Function:sulfuric ester hydrolase activity (GO:0008484) arylsulfatase A 3.1.6.8 ko00600 Sphingolipid metabolism ko04142 Lysosome Sulfatase R General function prediction only ; IPR000917 [Sulfatase, N-terminal] Golgi apparatus protein -- A0A8B9WCW1 Cytochrome b-c1 complex subunit 6 1718193.00233003 13499559 0.12727771346679 0.000185686121968542 -2.97394827176567 down -- -- ubiquinol-cytochrome c reductase subunit 6 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Ubiquinol-cytochrome c reductase hinge protein C Energy production and conversion ; IPR023184 [Ubiquinol-cytochrome C reductase hinge domain] mitochondrion protein -- A0A8B9XZ06 Transketolase TKT 41266474.9884865 1807735.5 22.8277173228531 0.000295231122709798 4.51271469813601 up -- -- transketolase 2.2.1.1 ko00030 Pentose phosphate pathway ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Transketolase G Carbohydrate transport and metabolism ; IPR005474 [Transketolase, N-terminal] ; IPR005475 [Transketolase-like, pyrimidine-binding domain] ; IPR033248 [Transketolase, C-terminal domain] nucleus protein -- A0A8C0AI90 Ribosomal protein S14 RPS14 26806177.5051116 3806085.375 7.04297851046276 0.0139217862427812 2.81618568078261 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S14e -- ko03010 Ribosome 40S ribosomal protein S14 J Translation, ribosomal structure and biogenesis ; IPR001971 [Ribosomal protein S11] -- -- A0A8B9Y640 Pyruvate kinase PKLR 14129071.6512114 2121544.5 6.65980452034421 0.0161506200940193 2.73547983170061 up 4 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:pyruvate kinase activity (GO:0004743),Biological Process:glycolytic process (GO:0006096),Molecular Function:potassium ion binding (GO:0030955) pyruvate kinase isozymes R/L 2.7.1.40 ko00010 Glycolysis / Gluconeogenesis ko00230 Purine metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko04910 Insulin signaling pathway ko04930 Type II diabetes mellitus ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04950 Maturity onset diabetes of the young Pyruvate kinase G Carbohydrate transport and metabolism ; IPR015793 [Pyruvate kinase, barrel] ; IPR015795 [Pyruvate kinase, C-terminal] -- -- A0A8C0A3H8 40S ribosomal protein S6 18254514.862819 2191614.5 8.32925446643057 0.00875404008115552 3.05818736885393 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S6e -- ko01521 EGFR tyrosine kinase inhibitor resistance ko03010 Ribosome ko04066 HIF-1 signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04910 Insulin signaling pathway ko05205 Proteoglycans in cancer 40S ribosomal protein S6 J Translation, ribosomal structure and biogenesis ; IPR001377 [Ribosomal protein S6e] -- -- A0A8B9YWV1 60S acidic ribosomal protein P0 RPLP0 26018710.1721145 4241319.625 6.13457896894873 0.0199740286633266 2.61696433162191 up 2 Cellular Component:intracellular (GO:0005622),Biological Process:ribosome biogenesis (GO:0042254) large subunit ribosomal protein LP0 -- ko03010 Ribosome 60S acidic ribosomal protein P0 J Translation, ribosomal structure and biogenesis ; IPR001790 [Ribosomal protein L10P] nucleus protein -- A0A8B9X7M2 Leucine rich repeat containing 74A LRRC74A 810565.522797517 7619246 0.106383954894949 4.97506306026611e-05 -3.23264751866326 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- LRR-containing protein S Function unknown ; IPR001611 [Leucine-rich repeat] cytoplasm protein -- A0A8B9Y712 S-formylglutathione hydrolase ESD 18202150.3769974 3219443.0625 5.6538196276914 0.0245067210058955 2.49922585798586 up -- -- S-formylglutathione hydrolase 3.1.2.12 ko01200 Carbon metabolism Esterase D R General function prediction only ; IPR000801 [Putative esterase] cytoplasm protein -- A0A8C0AGU9 Androglobin ADGB 2394450.17672053 18081494.0625 0.132425460442812 0.000244978396156871 -2.91674756999829 down 3 Molecular Function:calcium-dependent cysteine-type endopeptidase activity (GO:0004198),Cellular Component:intracellular (GO:0005622),Biological Process:proteolysis (GO:0006508) -- -- -- -- -- -- IPR001300 [Peptidase C2, calpain, catalytic domain] nucleus protein -- A0A8B9WW66 Histidine ammonia-lyase HAL 3084794.59920977 435475.125 7.08374467820583 0.0137076938184338 2.82451221348388 up -- -- histidine ammonia-lyase 4.3.1.3 ko00340 Histidine metabolism ko01100 Metabolic pathways Phenylalanine and histidine ammonia-lyase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001106 [Aromatic amino acid lyase] -- -- A0A8B9WAC7 Cytochrome c domain-containing protein 31507185.9813525 6272315.625 5.02321437010793 0.0325823875910383 2.32861084460806 up 2 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:heme binding (GO:0020037) cytochrome c -- ko00920 Sulfur metabolism ko01100 Metabolic pathways ko01524 Platinum drug resistance ko04115 p53 signaling pathway ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05016 Huntington's disease ko05134 Legionellosis ko05145 Toxoplasmosis ko05152 Tuberculosis ko05161 Hepatitis B ko05164 Influenza A ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05200 Pathways in cancer ko05210 Colorectal cancer ko05222 Small cell lung cancer ko05416 Viral myocarditis Cytochrome c C Energy production and conversion ; IPR009056 [Cytochrome c-like domain] mitochondrion protein -- A0A8B9YNP7 cathepsin X CTSZ 16419347.4144068 2549184.1875 6.44102042328662 0.017622153428112 2.68728926644472 up 2 Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234) cathepsin X 3.4.18.1 ko04142 Lysosome ko04210 Apoptosis Cysteine proteinase Cathepsin L O Posttranslational modification, protein turnover, chaperones ; IPR000668 [Peptidase C1A, papain C-terminal] lysosome protein -- A0A8B9YL75 40S ribosomal protein S16 23847388.7270527 2635279.1875 9.0492835977944 0.00688822847792907 3.1778035832655 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S16e -- ko03010 Ribosome 40S ribosomal protein S16 J Translation, ribosomal structure and biogenesis ; IPR000754 [Ribosomal protein S9] mitochondrion protein -- A0A8C0AAQ3 Dual specificity protein phosphatase CDC14B 4615121.36343558 17236210.875 0.267757304485611 0.0145560187779418 -1.9010021622968 down 2 Biological Process:protein dephosphorylation (GO:0006470),Molecular Function:protein tyrosine/serine/threonine phosphatase activity (GO:0008138) -- -- ko04110 Cell cycle Protein tyrosine phosphatase CDC14 V Defense mechanisms ; IPR000340 [Dual specificity phosphatase, catalytic domain] ; IPR029260 [Dual specificity/tyrosine protein phosphatase, N-terminal] nucleus protein -- A0A8B9WP97 Protein-serine/threonine kinase PDK2 1158721.26537655 17043037 0.0679879569220292 1.17239424856136e-06 -3.8785769732293 down -- -- pyruvate dehydrogenase kinase 2/3/4 2.7.11.2 -- Dehydrogenase kinase T Signal transduction mechanisms ; IPR003594 [Histidine kinase-like ATPase, C-terminal domain] ; IPR018955 [Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal] mitochondrion protein -- A0A8B9YHS5 Golgi associated RAB2 interactor protein-like Rab2B-binding domain-containing protein 1596158.35411466 13912968.25 0.114724502020959 8.77197070279684e-05 -3.12375455035947 down -- -- -- -- -- -- -- -- IPR022168 [Domain of unknown function DUF3699] -- -- A0A8B9X938 Cytochrome b5 domain containing 1 CYB5D1 6971196.07508189 23098495.78125 0.301803032591442 0.024983733352768 -1.72832079239369 down -- -- -- -- -- Cytochrome b5 C Energy production and conversion ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] -- -- A0A8B9XU19 Coilin COIL 2190745.35182327 6584744.5 0.332700130099698 0.0375631976255743 -1.58770566451223 down -- -- coilin -- -- -- -- -- IPR031722 [Coilin, N-terminal domain] nucleus protein -- A0A8B9Y3N4 Centrin 1 3136285.55859035 8938904.5 0.350857933272511 0.0463567682867731 -1.5110411112317 down 1 Molecular Function:calcium ion binding (GO:0005509) centrin-1 -- -- Ca2+-binding protein (centrin/caltractin), EF-Hand superfamily protein ZD Cytoskeleton ; Cell cycle control, cell division, chromosome partitioning ; IPR002048 [EF-hand domain] centrosome protein -- A0A8B9XAE5 Tropomyosin 3 8570585.67181532 2023228 4.2360948305457 0.0479638406827401 2.08273488631482 up -- -- tropomyosin 3 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko05200 Pathways in cancer ko05216 Thyroid cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Actin filament-coating protein tropomyosin Z Cytoskeleton ; IPR000533 [Tropomyosin] extracell protein -- A0A8B9WFN0 RAB8B, member RAS oncogene family RAB8B 911515.447104757 3332872.9375 0.273492408561032 0.0160682840910073 -1.87042730678124 down 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-8B -- ko04530 Tight junction GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] endoplasmic reticulum protein -- A0A8B9YPS5 Radial spoke head 10 homolog B 1473742.74481883 5371558.6875 0.274360354332223 0.0163055721679001 -1.86585607088616 down -- -- -- -- -- Junctional membrane complex protein Junctophilin and related MORN repeat proteins R General function prediction only ; IPR003409 [MORN motif] cytoplasm protein -- A0A8B9YQW2 Glutathione-disulfide reductase 6538941.70209719 212254420.5 0.030807093141776 3.05559590464469e-10 -5.02059362903948 down 3 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:cell redox homeostasis (GO:0045454),Biological Process:oxidation-reduction process (GO:0055114) glutathione reductase (NADPH) 1.8.1.7 ko00480 Glutathione metabolism ko04918 Thyroid hormone synthesis Pyridine nucleotide-disulphide oxidoreductase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR004099 [Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain] ; IPR023753 [FAD/NAD(P)-binding domain] cytoplasm protein -- A0A8B9WFL7 Calnexin CANX 21012625.681638 1739529.9375 12.0794849393835 0.00283108358735306 3.59448703537494 up 4 Molecular Function:calcium ion binding (GO:0005509),Cellular Component:endoplasmic reticulum (GO:0005783),Biological Process:protein folding (GO:0006457),Molecular Function:unfolded protein binding (GO:0051082) calnexin -- ko04141 Protein processing in endoplasmic reticulum ko04145 Phagosome ko04612 Antigen processing and presentation ko04918 Thyroid hormone synthesis ko05166 HTLV-I infection Calnexin O Posttranslational modification, protein turnover, chaperones ; IPR001580 [Calreticulin/calnexin] endoplasmic reticulum protein -- A0A8B9X919 Torsin family 4 member A TOR4A 1472749.30221947 4332288.4375 0.339947194990862 0.0409493133762759 -1.55661742923398 down 1 Molecular Function:ATP binding (GO:0005524) -- -- -- ATPase of the AAA+ superfamily R General function prediction only ; IPR010448 [Torsin] endoplasmic reticulum protein -- A0A8B9XL00 Malic enzyme ME1 43169594.984312 5943104.75 7.26381189635131 0.0128092625828245 2.86072684308658 up 3 Molecular Function:malate dehydrogenase (decarboxylating) (NAD+) activity (GO:0004471),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) 1.1.1.40 ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism NADP+-dependent malic enzyme C Energy production and conversion ; IPR012301 [Malic enzyme, N-terminal domain] ; IPR012302 [Malic enzyme, NAD-binding] cytoplasm protein -- A0A8B9YFQ0 Protein interacting with cyclin A1 PROCA1 13078893.6437141 85001519.25 0.153866586845906 0.000667839246421596 -2.70024812004613 down 3 Molecular Function:phospholipase A2 activity (GO:0004623),Biological Process:phospholipid metabolic process (GO:0006644),Biological Process:arachidonic acid secretion (GO:0050482) -- -- -- -- -- -- IPR016090 [Phospholipase A2 domain] plasma membrane protein -- A0A8B9WL30 Antithrombin-III SERPINC1 5773896.89412058 1039516.0625 5.55440853913749 0.0255986579118013 2.47363329449766 up -- -- antithrombin III -- ko04610 Complement and coagulation cascades Serpin V Defense mechanisms ; IPR023796 [Serpin domain] extracell protein -- A0A8B9WYI6 Tetratricopeptide repeat domain 29 TTC29 1717012.10956268 6876307.625 0.249699723049066 0.0104079781678387 -2.00173387376525 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR019734 [Tetratricopeptide repeat] cytoplasm protein -- A0A8B9WT18 Polypyrimidine tract-binding protein 1 PTBP1 3490969.06928299 443167.6875 7.87730957772726 0.0102463823749222 2.97770297465202 up 1 Molecular Function:nucleic acid binding (GO:0003676) polypyrimidine tract-binding protein 1 -- -- Polypyrimidine tract-binding protein A RNA processing and modification ; IPR000504 [RNA recognition motif domain] nucleus protein -- A0A8B9YQ06 Small ribosomal subunit protein uS17 RPS11 23877351.1428664 405160.28125 58.933099437092 4.64212932319649e-06 5.88100623796362 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S11e -- ko03010 Ribosome 40S ribosomal protein S11 J Translation, ribosomal structure and biogenesis ; IPR000266 [Ribosomal protein S17/S11] ; IPR032440 [40S ribosomal protein S11, N-terminal] -- -- A0A8B9X6J4 Nuclear pore complex protein Nup98-Nup96 NUP98 1368813.33569797 7233118.125 0.189242497086686 0.00236510732911661 -2.40169199219501 down 2 Cellular Component:nuclear pore (GO:0005643),Biological Process:transport (GO:0006810) nuclear pore complex protein Nup98-Nup96 -- ko03013 RNA transport ko05164 Influenza A Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR007230 [Peptidase S59, nucleoporin] ; IPR021967 [Nuclear protein 96] nucleus protein -- A0A8C0A428 Serine/threonine kinase like domain containing 1 STKLD1 3440161.15580325 202001707.875 0.0170303567825874 1.6017140079633e-13 -5.8757475302675 down 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) probable inactive protein kinase-like protein SgK071 -- -- Jun-N-terminal kinase (JNK) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] nucleus protein -- A0A8B9YR82 IQ domain-containing protein F5 2561299.96087388 7431144.5 0.344670993932883 0.0432449969433297 -1.53670820224532 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR000048 [IQ motif, EF-hand binding site] -- -- A0A8B9XXE3 Small ribosomal subunit protein uS13 B3GALT4 23528384.9921708 4503178.375 5.22483966497792 0.0296807904907612 2.38538676578866 up 5 Molecular Function:RNA binding (GO:0003723),Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S18e -- ko03010 Ribosome Ribosomal protein S18 J Translation, ribosomal structure and biogenesis ; IPR001892 [Ribosomal protein S13] cytoplasm protein -- A0A8B9XRM7 Histone H2A H2AC20 6636702.20292244 557358.6875 11.9074168067443 0.00296484570426708 3.5737885639826 up 1 Molecular Function:DNA binding (GO:0003677) histone H2A -- ko04217 Necroptosis ko05034 Alcoholism ko05322 Systemic lupus erythematosus Histone 2A B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] ; IPR032454 [Histone H2A, C-terminal domain] nucleus protein -- A0A8B9Y1M9 Small ribosomal subunit protein uS4 RPS9 21957104.6953408 4264982.375 5.14822870641776 0.0307437093452775 2.36407614568869 up 3 Molecular Function:RNA binding (GO:0003723),Cellular Component:intracellular (GO:0005622),Molecular Function:rRNA binding (GO:0019843) small subunit ribosomal protein S9e -- ko03010 Ribosome Ribosomal protein S4 J Translation, ribosomal structure and biogenesis ; IPR001912 [Ribosomal protein S4/S9, N-terminal] ; IPR002942 [RNA-binding S4 domain] nucleus protein -- A0A8B9WH02 N-acylneuraminate cytidylyltransferase CMAS 1389993.55962241 5120139.75 0.271475707205533 0.0155255201942725 -1.88110498953596 down -- -- -- -- ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways -- -- -- IPR003329 [Acylneuraminate cytidylyltransferase] nucleus protein -- A0A8B9YU16 serine--tRNA ligase SARS2 643165.812666325 3101505.875 0.207372108449198 0.00396091114781958 -2.26970623018645 down 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) seryl-tRNA synthetase 6.1.1.11 ko00970 Aminoacyl-tRNA biosynthesis Seryl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002314 [Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)] cytoplasm protein -- A0A8C0AB81 Ribosomal protein L19 RPL19 13683915.4251626 1311404.8125 10.4345472082539 0.00449008336780487 3.38329609312544 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L19e -- ko03010 Ribosome 60s ribosomal protein L19 J Translation, ribosomal structure and biogenesis ; IPR000196 [Ribosomal protein L19/L19e] -- -- A0A8B9XXH1 Metaxin 1 MTX1 1033230.26117668 8257343.375 0.125128653884601 0.000164592863949553 -2.99851589704106 down 2 Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:protein targeting to mitochondrion (GO:0006626) metaxin -- -- Translocase of outer mitochondrial membrane complex, subunit TOM37/Metaxin 1 U Intracellular trafficking, secretion, and vesicular transport ; IPR019564 [Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain] ; IPR033468 [Metaxin, glutathione S-transferase domain] mitochondrion protein -- A0A8C0ACI8 Nucleoporin 54 NUP54 676468.218170865 4282516.75 0.157960437205731 0.000790039851035806 -2.66236482885373 down -- -- nuclear pore complex protein Nup54 -- ko03013 RNA transport Nuclear pore complex, p54 component (sc Nup57) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR025712 [Nucleoporin Nup54, alpha-helical domain] -- -- A0A8C0AJQ0 Bone morphogenetic protein 3 BMP3 902030.468604113 2621107.3125 0.344140991214801 0.0429839575357553 -1.53892835073409 down 2 Molecular Function:growth factor activity (GO:0008083),Biological Process:growth (GO:0040007) bone morphogenetic protein 3/3B -- -- Transforming growth factor beta, bone morphogenetic protein and related proteins T Signal transduction mechanisms ; IPR001111 [Transforming growth factor-beta, N-terminal] ; IPR001839 [Transforming growth factor-beta, C-terminal] extracell protein -- A0A8C0A4Z8 Ribosome binding protein 1 RRBP1 12203229.1451601 665088.5625 18.3482769562138 0.000672328565460466 4.19757268419885 up 2 Biological Process:protein transport (GO:0015031),Cellular Component:integral component of endoplasmic reticulum membrane (GO:0030176) ribosome-binding protein 1 -- ko04141 Protein processing in endoplasmic reticulum -- -- -- IPR007794 [Ribosome receptor lysine/proline rich] endoplasmic reticulum protein -- A0A8C0A2L2 S-(hydroxymethyl)glutathione dehydrogenase ADH5 37157896.6641644 362609.875 102.473482455944 2.65330905789571e-07 6.67910681483407 up 1 Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00010 Glycolysis / Gluconeogenesis ko00071 Fatty acid degradation ko00350 Tyrosine metabolism ko00830 Retinol metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01100 Metabolic pathways ko01200 Carbon metabolism ko05204 Chemical carcinogenesis Alcohol dehydrogenase, class III Q Secondary metabolites biosynthesis, transport and catabolism ; IPR013149 [Alcohol dehydrogenase, C-terminal] ; IPR013154 [Alcohol dehydrogenase, N-terminal] cytoplasm protein -- A0A8B9WIR8 Barrier to autointegration factor 2 BANF2 15926919.1997794 64197532.5 0.248092388905748 0.0100823586979279 -2.01105061865083 down 1 Molecular Function:DNA binding (GO:0003677) -- -- -- DNA-bridging protein BAF BL Chromatin structure and dynamics ; Replication, recombination and repair ; IPR004122 [Barrier- to-autointegration factor, BAF] nucleus protein -- A0A8B9XE99 Centromere protein V 1506992.68159274 4467738.5 0.337305480522806 0.0396959100412389 -1.56787233550304 down 2 Biological Process:metabolic process (GO:0008152),Molecular Function:carbon-sulfur lyase activity (GO:0016846) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006913 [Glutathione-dependent formaldehyde-activating enzyme/centromere protein V] -- -- A0A8B9YBP4 Ribosomal protein L18 8941921.07791674 1057012.25 8.4596191557068 0.00837408232212535 3.08059271599999 up -- -- large subunit ribosomal protein L18e -- ko03010 Ribosome 60s ribosomal protein L18 J Translation, ribosomal structure and biogenesis ; IPR021131 [Ribosomal protein L18e/L15P] cytoplasm protein -- A0A8B9WE67 Ubiquitin conjugating enzyme E2 V1 4966576.35884445 583610.625 8.51008557091374 0.00823244441198096 3.08917363862243 up -- -- ubiquitin-conjugating enzyme E2 variant -- Ubiquitin-conjugating enzyme E2 O Posttranslational modification, protein turnover, chaperones ; -- -- -- A0A8B9WHK3 60S ribosomal protein L21 12871801.4687371 2021636.5 6.36702071254506 0.0181571711529457 2.67061845745835 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L21e -- ko03010 Ribosome 60S ribosomal protein L21 J Translation, ribosomal structure and biogenesis ; IPR001147 [Ribosomal protein L21e] -- -- A0A8B9YUC4 Ribosomal protein L10 like 13558149.09 1959873.5625 6.91786926943661 0.0146051231685371 2.79032775061203 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L10e -- ko03010 Ribosome 60s ribosomal protein L10 J Translation, ribosomal structure and biogenesis ; IPR016180 [Ribosomal protein L10e/L16] -- -- A0A8B9WXK8 VWFA domain-containing protein 1238169.07529188 15980753.5625 0.0774787665956713 3.74759692489575e-06 -3.6900552022826 down 2 Molecular Function:receptor activity (GO:0004872),Cellular Component:integral component of membrane (GO:0016021) anthrax toxin receptor -- ko04621 NOD-like receptor signaling pathway -- -- -- IPR008400 [Anthrax toxin receptor, extracellular] plasma membrane protein -- A0A8B9YKG4 Coiled-coil domain containing 83 CCDC83 219903.679657526 1595355 0.137839966438521 0.000322494075109832 -2.85893383948135 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9X541 Coenzyme A synthase COASY 5891704.75750278 609131.1875 9.6723084918432 0.00565376437348595 3.27386025911917 up 5 Molecular Function:catalytic activity (GO:0003824),Molecular Function:dephospho-CoA kinase activity (GO:0004140),Molecular Function:ATP binding (GO:0005524),Biological Process:biosynthetic process (GO:0009058),Biological Process:coenzyme A biosynthetic process (GO:0015937) -- -- ko00770 Pantothenate and CoA biosynthesis ko01100 Metabolic pathways Predicted nucleotidyltransferase R General function prediction only ; IPR001977 [Dephospho-CoA kinase] ; IPR004821 [Cytidyltransferase-like domain] -- -- A0A8B9XC19 Serine protease 45, pseudogene 344770.795151605 2841709.75 0.121325126590288 0.000131959610765183 -3.04304972948061 down 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) -- -- -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] plasma membrane protein -- A0A8B9Y5T1 Nucleophosmin 9838710.12812823 1268129.78125 7.75844103150876 0.0106897772560631 2.9557667887445 up 1 Molecular Function:nucleic acid binding (GO:0003676) nucleophosmin 1 -- -- -- -- -- IPR024057 [Nucleoplasmin core domain] ; IPR032569 [Nucleophosmin, C-terminal] nucleus protein -- A0A8B9YAQ5 Progesterone receptor membrane component 1 PGRMC1 38571161.1448044 2797048 13.7899532452802 0.00183053431070208 3.78554566030222 up -- -- membrane-associated progesterone receptor component -- -- Putative steroid membrane receptor Hpr6.6/25-Dx R General function prediction only ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] -- -- A0A8B9YGZ6 Glycine N-methyltransferase GNMT 24341260.4378468 5812664.5 4.187625216946 0.0491832611136248 2.06613233007954 up -- -- glycine N-methyltransferase 2.1.1.20 ko00260 Glycine, serine and threonine metabolism -- -- -- -- cytoplasm protein -- A0A8B9Y0Y2 Family with sequence similarity 71 member E1 GARIN5A 2959473.85863824 8421782.875 0.351407047956961 0.0466386772570896 -1.50878496799586 down -- -- -- -- -- -- -- -- IPR022168 [Domain of unknown function DUF3699] -- -- A0A8B9X1L0 Testis expressed 29 TEX29 39155324.6144414 118741234.5 0.329753390044479 0.0362335807458739 -1.60054060364339 down -- -- -- -- -- -- -- -- IPR031685 [Testis-expressed sequence 29 protein] -- -- A0A8B9X2P8 Eukaryotic translation initiation factor 3 subunit C EIF3C 8109704.67109629 482165.1875 16.8193492216737 0.00092037914343715 4.07204998045501 up 5 Molecular Function:translation initiation factor activity (GO:0003743),Molecular Function:protein binding (GO:0005515),Cellular Component:eukaryotic translation initiation factor 3 complex (GO:0005852),Biological Process:translational initiation (GO:0006413),Molecular Function:translation initiation factor binding (GO:0031369) translation initiation factor 3 subunit C -- ko03013 RNA transport Translation initiation factor 3, subunit c (eIF-3c) J Translation, ribosomal structure and biogenesis ; IPR000717 [Proteasome component (PCI) domain] ; IPR008905 [Eukaryotic translation initiation factor 3 subunit C, N-terminal domain] -- -- A0A8C0AEM4 ADP-ribosylation factor 6 ARF6 3446412.90029766 9757376.25 0.353211028456309 0.0475713659000718 -1.50139770532446 down 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor 6 -- ko04014 Ras signaling pathway ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis GTP-binding ADP-ribosylation factor Arf6 (dArf3) U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] lysosome protein -- A0A8B9YIM8 Golgi associated RAB2 interactor protein-like Rab2B-binding domain-containing protein 2166416.05165854 6400278.25 0.338487791786012 0.0402541731608176 -1.56282429372341 down -- -- -- -- -- -- -- -- IPR022168 [Domain of unknown function DUF3699] -- -- A0A8B9YUX3 Ribosomal protein L26 RPL26 30858273.7604068 2440064.875 12.646497261843 0.00243914497715035 3.66066594757538 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Biological Process:translation (GO:0006412),Cellular Component:large ribosomal subunit (GO:0015934) large subunit ribosomal protein L26e -- ko03010 Ribosome 60S ribosomal protein L26 J Translation, ribosomal structure and biogenesis ; IPR005756 [Ribosomal protein L26/L24P, eukaryotic/archaeal] ; IPR005824 [KOW] -- -- A0A8B9WZG2 Lactoylglutathione lyase 48203708.0369176 812345.1875 59.3389470124947 4.48915161032874e-06 5.89090742087422 up -- -- lactoylglutathione lyase 4.4.1.5 ko00620 Pyruvate metabolism Glyoxalase G Carbohydrate transport and metabolism ; IPR004360 [Glyoxalase/fosfomycin resistance/dioxygenase domain] -- -- A0A8B9W6E3 Ubiquitin conjugating enzyme E2 N UBE2N 9076030.46074128 412393.03125 22.0082052144068 0.000340002928811079 4.45996959205447 up -- -- ubiquitin-conjugating enzyme E2 N 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] nucleus protein -- A0A8B9XAJ4 BRI3 binding protein BRI3BP 1881007.80256691 5811891.25 0.323648141655594 0.0335659148358445 -1.6275018747523 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9WG21 Nitrilase family member 2 NIT2 6408587.55654117 1332420.25 4.80973443366773 0.0360518776883101 2.26595723873387 up 1 Biological Process:nitrogen compound metabolic process (GO:0006807) omega-amidase 3.5.1.3 ko00250 Alanine, aspartate and glutamate metabolism Carbon-nitrogen hydrolase E Amino acid transport and metabolism ; IPR003010 [Carbon-nitrogen hydrolase] cytoplasm protein -- A0A8B9W620 Protein Flattop CFAP126 6200512.50197663 19733177.25 0.314217645917949 0.0296765522576253 -1.67016389272924 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9Y1A1 DnaJ heat shock protein family (Hsp40) member A2 DNAJA2 4975381.49498061 893493.125 5.56846085970791 0.0254406811193822 2.47727861716739 up 2 Molecular Function:heat shock protein binding (GO:0031072),Molecular Function:unfolded protein binding (GO:0051082) DnaJ homolog subfamily A member 2 -- ko04141 Protein processing in endoplasmic reticulum Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001305 [Heat shock protein DnaJ, cysteine-rich domain] ; IPR001623 [DnaJ domain] ; IPR002939 [Chaperone DnaJ, C-terminal] nucleus protein -- A0A8B9XHU2 40S ribosomal protein S7 COLEC11 7087476.13301285 686714.625 10.3208463530434 0.00464372361660023 3.36748937759354 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S7e -- ko03010 Ribosome 40S ribosomal protein S7 J Translation, ribosomal structure and biogenesis ; IPR000554 [Ribosomal protein S7e] -- -- A0A8B9YC05 Coatomer subunit delta ARCN1 12751308.1544205 1810278.46875 7.04383793683703 0.0139172303441461 2.81636171632256 up -- -- coatomer subunit delta -- -- Medium subunit of clathrin adaptor complex U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] ; IPR028565 [Mu homology domain] -- -- A0A8B9XXD3 Protein disulfide isomerase like, testis expressed PDILT 239713.266221932 747123.4375 0.320848275117767 0.0323818744025551 -1.64003686757951 down 1 Biological Process:cell redox homeostasis (GO:0045454) protein disulfide-isomerase-like protein of the testis -- -- Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] endoplasmic reticulum protein -- A0A8C0A759 Protein FAM47E 532661.341170226 1991887.84375 0.267415328047496 0.0144688764542923 -1.90284593288045 down -- -- -- -- -- -- -- -- IPR032743 [FAM47 family] -- -- A0A8B9WZZ7 26S proteasome non-ATPase regulatory subunit 9 PSMD9 5247137.87388102 1194582 4.39244679216749 0.0442807164251475 2.13502481027667 up 1 Molecular Function:protein binding (GO:0005515) 26S proteasome non-ATPase regulatory subunit 9 -- -- 26S proteasome regulatory complex, subunit PSMD9 O Posttranslational modification, protein turnover, chaperones ; IPR001478 [PDZ domain] -- -- A0A8B9WJC0 Ribosomal protein L24 31465463.123821 1315809.1875 23.913393691683 0.00024624054493779 4.57974698088547 up -- -- large subunit ribosomal protein L24e -- ko03010 Ribosome 60s ribosomal protein L24 J Translation, ribosomal structure and biogenesis ; IPR000988 [Ribosomal protein L24e-related] nucleus protein -- A0A8B9YW34 60S ribosomal protein L18a RPL18A 7969034.53239185 412287.65625 19.3288215438583 0.000555069197648817 4.27268177565127 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L18Ae -- ko03010 Ribosome 60S ribosomal protein L18A J Translation, ribosomal structure and biogenesis ; IPR023573 [Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A] -- -- A0A8B9WBJ3 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 4180024.11167901 13403545 0.311859594732514 0.0287478958271953 -1.68103144905289 down -- -- succinate dehydrogenase (ubiquinone) cytochrome b560 subunit -- ko00020 Citrate cycle (TCA cycle) ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko01200 Carbon metabolism ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Succinate dehydrogenase, cytochrome b subunit G Carbohydrate transport and metabolism ; IPR000701 [Succinate dehydrogenase/Fumarate reductase, transmembrane subunit] mitochondrion protein -- A0A8B9WNH1 Glutamyl-prolyl-tRNA synthetase 1 EPRS1 3882016.61383607 616862.875 6.29315974613656 0.018711409046834 2.65378456487626 up 8 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:proline-tRNA ligase activity (GO:0004827),Molecular Function:ATP binding (GO:0005524),Cellular Component:cytoplasm (GO:0005737),Biological Process:tRNA aminoacylation for protein translation (GO:0006418),Biological Process:prolyl-tRNA aminoacylation (GO:0006433),Biological Process:tRNA aminoacylation (GO:0043039) -- -- ko00860 Porphyrin and chlorophyll metabolism ko00970 Aminoacyl-tRNA biosynthesis ko01100 Metabolic pathways Glutamyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR000738 [WHEP-TRS domain] ; IPR002314 [Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)] ; IPR004046 [Glutathione S-transferase, C-terminal] ; IPR004154 [Anticodon-binding] ; IPR016061 [Proline-tRNA ligase, class II, C-terminal] ; IPR020058 [Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain] ; IPR020059 [Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain] cytoplasm protein -- A0A8B9X8C5 Small ribosomal subunit protein uS12 15443942.2832298 816335.9375 18.9186112895217 0.000600883309726555 4.24173428719835 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S23e -- ko03010 Ribosome 40S ribosomal protein S23 J Translation, ribosomal structure and biogenesis ; IPR006032 [Ribosomal protein S12/S23] mitochondrion protein -- A0A8B9Y8C7 60S ribosomal protein L6 19856994.140497 615918.875 32.2396259418044 7.26555416684462e-05 5.01076310007352 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L6e -- ko03010 Ribosome 60s ribosomal protein L6 J Translation, ribosomal structure and biogenesis ; IPR000915 [60S ribosomal protein L6E] ; IPR005568 [Ribosomal protein L6, N-terminal] -- -- A0A8B9WC89 Ribosomal protein L37a RPL37A 7063756.45715892 1372004.875 5.14849224362918 0.0307399722119795 2.36414999518504 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L37Ae -- ko03010 Ribosome 60S ribosomal protein L37 J Translation, ribosomal structure and biogenesis ; IPR002674 [Ribosomal protein L37ae] -- -- A0A8B9WQE4 Hydroxymethylglutaryl-CoA lyase, mitochondrial HMGCL 7375331.71071816 631158 11.6853968589769 0.00314895398078652 3.54663482659094 up 1 Molecular Function:catalytic activity (GO:0003824) hydroxymethylglutaryl-CoA lyase 4.1.3.4 ko00072 Synthesis and degradation of ketone bodies ko00280 Valine, leucine and isoleucine degradation ko00650 Butanoate metabolism ko01100 Metabolic pathways ko04146 Peroxisome Hydroxymethylglutaryl-CoA lyase CE Energy production and conversion ; Amino acid transport and metabolism ; IPR000891 [Pyruvate carboxyltransferase] mitochondrion protein -- A0A8B9W786 J domain-containing protein 1599900.95040188 5975633.5 0.267737462547173 0.0145509533955911 -1.90110907600712 down -- -- DnaJ homolog subfamily B member 1 -- ko04141 Protein processing in endoplasmic reticulum ko05164 Influenza A Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR002939 [Chaperone DnaJ, C-terminal] nucleus protein -- A0A8B9WL72 Protein phosphatase methylesterase 1 PPME1 2392564.07304402 472640.5 5.06212242294941 0.0319957555318343 2.33974239817288 up -- -- protein phosphatase methylesterase 1 3.1.1.89 -- Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- A0A8B9W6S9 AP-2 complex subunit mu AP2M1 2113764.2865494 325346.71875 6.49695898169989 0.0172306362513573 2.69976459681355 up -- -- AP-2 complex subunit mu-1 -- ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease Adaptor complexes medium subunit family U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] ; IPR028565 [Mu homology domain] plasma membrane protein -- A0A8B9WSP4 EF-hand calcium binding domain 2 EFCAB2 735879.315123081 4900680.75 0.150158590747435 0.000570185355515545 -2.73544107937171 down -- -- -- -- -- Calmodulin and related proteins (EF-Hand superfamily) T Signal transduction mechanisms ; -- centrosome protein -- A0A8B9W4Z3 Secretion associated Ras related GTPase 1B SAR1B 7191612.19068366 1195767 6.01422533878562 0.0210034488051985 2.58837892329239 up 1 Molecular Function:GTP binding (GO:0005525) GTP-binding protein SAR1 3.6.5.- ko04141 Protein processing in endoplasmic reticulum ko05134 Legionellosis Vesicle coat complex COPII, GTPase subunit SAR1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] endosome protein -- A0A8B9XC52 Kinetochore localized astrin (SPAG5) binding protein KNSTRN 2459953.83704297 7004044 0.351219072444858 0.0465420680628831 -1.50955690441472 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9Y6Q7 Glutathione S-transferase 61573116.972753 4442753.5 13.8592242339695 0.00179994703347044 3.79277460018877 up 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046 [Glutathione S-transferase, C-terminal] cytoplasm protein -- A0A8B9XLE8 Cadherin 1 CDH1 584005179.615438 73398453 7.95664153324101 0.00996301684410316 2.99215960341047 up 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin 1, type 1, E-cadherin -- ko04015 Rap1 signaling pathway ko04371 Apelin signaling pathway ko04390 Hippo signaling pathway ko04514 Cell adhesion molecules (CAMs) ko04520 Adherens junction ko05100 Bacterial invasion of epithelial cells ko05200 Pathways in cancer ko05213 Endometrial cancer ko05216 Thyroid cancer ko05218 Melanoma ko05219 Bladder cancer ko05226 Gastric cancer FOG: Cadherin repeats S Function unknown ; IPR000233 [Cadherin, cytoplasmic domain] ; IPR002126 [Cadherin] ; IPR014868 [Cadherin prodomain] cytoplasm protein -- A0A8B9XLD9 peptidylprolyl isomerase FKBP4 5639946.71406573 420712.8125 13.4056927825694 0.00201207302728451 3.74477387207067 up 1 Molecular Function:protein binding (GO:0005515) FK506-binding protein 4/5 5.2.1.8 ko04915 Estrogen signaling pathway FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] ; IPR001440 [Tetratricopeptide repeat 1] ; IPR013105 [Tetratricopeptide repeat 2] nucleus protein -- A0A8C0AB88 tryptophan--tRNA ligase WARS2 18431785.7507462 832701.5 22.1349256014865 0.00033257755009253 4.46825261923586 up 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) tryptophanyl-tRNA synthetase 6.1.1.2 ko00970 Aminoacyl-tRNA biosynthesis Mitochondrial tryptophanyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002305 [Aminoacyl-tRNA synthetase, class Ic] mitochondrion protein -- W5QM99 Major prion protein PRNP 9294220.5514843 872197.8125 10.656092480723 0.00420811172310522 3.41360660313942 up 2 Cellular Component:membrane (GO:0016020),Biological Process:protein homooligomerization (GO:0051260) prion protein -- ko04216 Ferroptosis ko05020 Prion diseases -- -- -- IPR022416 [Prion/Doppel protein, beta-ribbon domain] ; IPR025860 [Major prion protein N-terminal domain] -- -- A0A8B9WPM9 Cell division cycle 34 CDC34 1892034.11496625 7661148.0625 0.246964828186448 0.0098580520722364 -2.0176225017174 down -- -- ubiquitin-conjugating enzyme E2 R 2.3.2.23 ko04120 Ubiquitin mediated proteolysis ko05168 Herpes simplex infection Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] nucleus protein -- A0A8B9XML9 Proteasome activator subunit 1 PSME1 7355984.1693369 476875.96875 15.4253614176001 0.00124802532099149 3.94723238713213 up 1 Cellular Component:proteasome activator complex (GO:0008537) proteasome activator subunit 1 (PA28 alpha) -- ko03050 Proteasome ko04612 Antigen processing and presentation Proteasome activator subunit O Posttranslational modification, protein turnover, chaperones ; IPR003185 [Proteasome activator pa28, N-terminal domain] ; IPR003186 [Proteasome activator pa28, C-terminal domain] -- -- A0A8B9YW29 IQ motif containing F2 IQCF2 3717547.74985351 11652962 0.319021700221241 0.0316227736960731 -1.64827353379131 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR000048 [IQ motif, EF-hand binding site] -- -- A0A8C0AG75 40S ribosomal protein S25 21452824.4351722 2270289.6875 9.44937756326403 0.00606173112701174 3.24021930118905 up -- -- small subunit ribosomal protein S25e -- ko03010 Ribosome 40S ribosomal protein S25 J Translation, ribosomal structure and biogenesis ; IPR004977 [Ribosomal protein S25] -- -- A0A8B9WJL6 Large ribosomal subunit protein eL31 17359208.443867 408732.15625 42.4708655250733 2.16844323657355e-05 5.40840160493852 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L31e -- ko03010 Ribosome 60S ribosomal protein L31 J Translation, ribosomal structure and biogenesis ; IPR000054 [Ribosomal protein L31e] -- -- A0A8B9Y1T1 Aldose 1-epimerase GALM 7661625.69432184 1394619.09375 5.49370486081647 0.0262953000480266 2.45777940635957 up 2 Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:isomerase activity (GO:0016853) aldose 1-epimerase 5.1.3.3 ko00010 Glycolysis / Gluconeogenesis ko00052 Galactose metabolism ko01100 Metabolic pathways Predicted mutarotase G Carbohydrate transport and metabolism ; IPR008183 [Aldose 1-/Glucose-6-phosphate 1-epimerase] -- -- A0A8B9Y3F2 Dehydrogenase/reductase 1 DHRS1 8238512.80732217 648053.4375 12.7127059754577 0.00239779386642025 3.66819924418068 up -- -- dehydrogenase/reductase SDR family member 1 1.1.-.- -- Reductases with broad range of substrate specificities R General function prediction only ; IPR002347 [Short-chain dehydrogenase/reductase SDR] endoplasmic reticulum protein -- A0A8B9XH19 Syndecan SDC4 931834.95873356 3998203.25 0.233063428862342 0.00736341328808908 -2.1012054530899 down -- -- syndecan 4 -- ko04512 ECM-receptor interaction ko04514 Cell adhesion molecules (CAMs) ko05205 Proteoglycans in cancer ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR027789 [Syndecan/Neurexin domain] -- -- A0A8B9XXQ8 Uncharacterized protein 586364.77531658 2067211.5625 0.283650104301591 0.0189861201283306 -1.81781570038193 down 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) -- -- -- -- -- -- IPR000315 [B-box-type zinc finger] ; IPR003877 [SPRY domain] cytoplasm protein -- A0A8B9W9J6 H1.0 linker histone H1-0 20879767.5395076 984140.0625 21.2162560341939 0.000391150761262144 4.4070981857556 up 4 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) histone H1/5 -- -- Histone H1 B Chromatin structure and dynamics ; IPR005818 [Linker histone H1/H5, domain H15] nucleus protein -- A0A8C0A606 Outer dense fiber of sperm tails 3 like 2 ODF3L2 1207156.09436227 10097573.75 0.119549123804347 0.000118609577563766 -3.06432453855389 down -- -- -- -- -- -- -- -- IPR010736 [Sperm-tail PG-rich repeat] -- -- A0A8B9WZ57 Disintegrin and metalloproteinase domain-containing protein 20-like 281255.080658154 887783.5625 0.316805911416223 0.0307160614739641 -1.65832883935841 down 2 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508) -- -- -- Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family O Posttranslational modification, protein turnover, chaperones ; IPR001590 [Peptidase M12B, ADAM/reprolysin] ; IPR001762 [Disintegrin domain] ; IPR002870 [Peptidase M12B, propeptide] ; IPR006586 [ADAM, cysteine-rich] plasma membrane protein -- A0A8B9VZ13 1,4-alpha-glucan branching enzyme GBE1 7459096.56726811 1399692.5 5.32909661748428 0.0283069157314899 2.41389098965675 up 3 Molecular Function:catalytic activity (GO:0003824),Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:cation binding (GO:0043169) 1,4-alpha-glucan branching enzyme 2.4.1.18 ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways 1,4-alpha-glucan branching enzyme/starch branching enzyme II G Carbohydrate transport and metabolism ; IPR004193 [Glycoside hydrolase, family 13, N-terminal] ; IPR006047 [Glycosyl hydrolase, family 13, catalytic domain] ; IPR006048 [Alpha-amylase/branching enzyme, C-terminal all beta] -- -- P01967 Hemoglobin subunit alpha-1 597695164.270105 4492726 133.036193231037 6.13812128329603e-08 7.05567498205374 up 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) hemoglobin subunit alpha -- ko05143 African trypanosomiasis ko05144 Malaria Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- A0A8C0A838 Trafficking protein particle complex subunit TRAPPC3 674471.679072054 5516085.0625 0.12227361823285 0.000139565664365263 -3.03181493346153 down -- -- trafficking protein particle complex subunit 3 -- -- Transport protein particle (TRAPP) complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR007194 [Transport protein particle (TRAPP) component] -- -- A0A8B9XAS6 Globin family profile domain-containing protein 629262143.651512 2284652.875 275.430088543106 7.04250459740314e-10 8.10554236079742 up 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) hemoglobin subunit beta -- ko05143 African trypanosomiasis ko05144 Malaria Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- A0A8C0AG50 Trafficking protein particle complex subunit TRAPPC4 4149280.55248624 20558518 0.201827804537576 0.00340921571484512 -2.3088031557986 down 2 Biological Process:transport (GO:0006810),Cellular Component:TRAPP complex (GO:0030008) trafficking protein particle complex subunit 4 -- -- Transport protein particle (TRAPP) complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR007233 [Trafficking protein particle complex subunit] -- -- A0A8B9WTF8 Isochorismatase domain containing 1 ISOC1 3560486.41433421 335657.5 10.6074984599903 0.00426807005645206 3.40701256406379 up 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Mitochondrial associated endoribonuclease MAR1 (isochorismatase superfamily) R General function prediction only ; IPR000868 [Isochorismatase-like] -- -- A0A8B9YQP1 Large ribosomal subunit protein eL28 8758257.92280573 749744.3125 11.6816597028947 0.00315216986191705 3.54617335840571 up -- -- large subunit ribosomal protein L28e -- ko03010 Ribosome 60S ribosomal protein L28 J Translation, ribosomal structure and biogenesis ; IPR029004 [Ribosomal L28e/Mak16] -- -- A4ZXY3 ATP synthase subunit a ATP6 351512.399317134 5937561.625 0.0592014738570623 3.22007649678268e-07 -4.07822309669404 down 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit a -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease ATP synthase F0 subunit 6 and related proteins C Energy production and conversion ; IPR000568 [ATP synthase, F0 complex, subunit A] mitochondrion protein -- A0A8C0A5A7 UPAR/Ly6 domain-containing protein 593369.956929649 5221603 0.113637508812839 8.17478603912523e-05 -3.13748898498747 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9X7C0 Large ribosomal subunit protein eL38 6774686.56600966 371432.84375 18.2393309584908 0.000687108253528028 4.18898090549912 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L38e -- ko03010 Ribosome 60S ribosomal protein L38 J Translation, ribosomal structure and biogenesis ; IPR002675 [Ribosomal protein L38e] -- -- A0A8B9Z2E2 Abhydrolase domain containing 14B ABHD14B 10143390.7653698 513602.84375 19.7494832608582 0.000512353081442324 4.30374300099989 up -- -- abhydrolase domain-containing protein 14 -- -- -- -- -- IPR000073 [Alpha/beta hydrolase fold-1] nucleus protein -- A0A8B9WP81 Eukaryotic translation initiation factor 3 subunit E EIF3E 2210677.84162715 7322541.1875 0.301900362868686 0.0250186442176056 -1.72785560398965 down 1 Molecular Function:protein binding (GO:0005515) translation initiation factor 3 subunit E -- ko03013 RNA transport ko05160 Hepatitis C Translation initiation factor 3, subunit e (eIF-3e) J Translation, ribosomal structure and biogenesis ; IPR000717 [Proteasome component (PCI) domain] ; IPR019010 [Eukaryotic translation initiation factor 3 subunit E, N-terminal] cytoplasm protein -- A0A8B9W0P4 Large ribosomal subunit protein eL34 RPL34 86179968.3240323 411595.6875 209.380153731645 4.053714579228e-09 7.70998089149974 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L34e -- ko03010 Ribosome 60s ribosomal protein L34 J Translation, ribosomal structure and biogenesis ; IPR008195 [Ribosomal protein L34Ae] -- -- A0A8B9XFF0 NFKB inhibitor interacting Ras like 2 NKIRAS2 1145996.81896108 3786768.5625 0.302631861453001 0.0252819693205023 -1.72436421063589 down 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) NF-kappa-B inhibitor-interacting Ras-like protein -- -- Ras family small GTPase T Signal transduction mechanisms ; IPR001806 [Small GTPase superfamily] cytoplasm protein -- A0A8B9YUT6 Heterogeneous nuclear ribonucleoprotein L HNRNPL 2784574.32356383 410683.9375 6.78033414336744 0.0154048344226511 2.76135637293397 up 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein L -- -- Heterogeneous nuclear ribonucleoprotein L (contains RRM repeats) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] nucleus protein -- A0A8B9XRI1 Hydroxysteroid 17-beta dehydrogenase 11 HSD17B11 19088831.0578493 257591.703125 74.104991838911 1.47639647226373e-06 6.21149882309562 up -- -- -- -- -- Hydroxysteroid 17-beta dehydrogenase 11 Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] cytoplasm protein -- A0A8C0AJT8 Aldehyde dehydrogenase ALDH3A2 10019540.837606 794139.5 12.6168523761959 0.00245793937766005 3.65728012979954 up 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) aldehyde dehydrogenase (NAD+) 1.2.1.3 ko00010 Glycolysis / Gluconeogenesis ko00053 Ascorbate and aldarate metabolism ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00561 Glycerolipid metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] endoplasmic reticulum protein -- A0A8B9XYT3 Acyl-CoA synthetase long chain family member 3 ACSL3 9409468.22653275 33856807.21875 0.277919538181431 0.0173020125188177 -1.84726083304907 down 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) long-chain acyl-CoA synthetase 6.2.1.3 ko00061 Fatty acid biosynthesis ko00071 Fatty acid degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04146 Peroxisome ko04216 Ferroptosis ko04920 Adipocytokine signaling pathway Acyl-CoA synthetase I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] cytoplasm protein -- A0A8B9XJ67 Transmembrane protein 65 TMEM65 903891.550064202 2929711.125 0.308525827802972 0.027464865847361 -1.69653682728392 down -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019537 [Transmembrane protein 65] -- -- A0A8C0AB83 26S proteasome non-ATPase regulatory subunit 13 PSMD13 28809537.1925754 84326793.75 0.341641557936921 0.0417647297249601 -1.54944461705188 down -- -- 26S proteasome regulatory subunit N9 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN9/PSMD13 O Posttranslational modification, protein turnover, chaperones ; -- -- -- A0A8B9YWN4 60S ribosomal protein L13 8983530.16661649 367415.125 24.4506269757308 0.000225597127593173 4.61179955487797 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L13e -- ko03010 Ribosome 60S Ribosomal protein L13 J Translation, ribosomal structure and biogenesis ; IPR001380 [Ribosomal protein L13e] -- -- A0A8B9Y3S5 RING-type E3 ubiquitin transferase 16466441.4768445 2596767.625 6.3411301490038 0.0183491023198091 2.6647399878505 up -- -- E3 ubiquitin-protein ligase RNF138 2.3.2.27 -- -- -- -- -- nucleus protein zf-MIZ A0A8B9XGY3 Peptidase D PEPD 29200442.9589992 575897 50.7042803817335 9.55382094063774e-06 5.66403563747768 up 2 Molecular Function:aminopeptidase activity (GO:0004177),Molecular Function:manganese ion binding (GO:0030145) Xaa-Pro dipeptidase 3.4.13.9 -- Putative metallopeptidase R General function prediction only ; IPR000994 [Peptidase M24] ; IPR007865 [Aminopeptidase P, N-terminal] -- -- A0A8B9WEP6 Translocase of outer mitochondrial membrane 70 TOMM70 1200136.75658178 12204727 0.0983337649897273 2.70041694822774e-05 -3.34616930811195 down 1 Molecular Function:protein binding (GO:0005515) mitochondrial import receptor subunit TOM70 -- -- Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72 U Intracellular trafficking, secretion, and vesicular transport ; IPR001440 [Tetratricopeptide repeat 1] ; IPR019734 [Tetratricopeptide repeat] cytoplasm protein -- A0A8B9YL53 Semaphorin 4A SEMA4A 10419599.3238608 1178881.75 8.83854493791324 0.00737900174165019 3.14380888277954 up 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) semaphorin 4 -- ko04360 Axon guidance Semaphorins T Signal transduction mechanisms ; IPR001627 [Sema domain] ; IPR002165 [Plexin repeat] extracell protein -- A0A8C0A746 Small ribosomal subunit protein uS10 13644470.5417281 1019130.75 13.3883415270593 0.00202077158953458 3.74290535361708 up -- -- small subunit ribosomal protein S20e -- ko03010 Ribosome 40S ribosomal protein S20 J Translation, ribosomal structure and biogenesis ; IPR027486 [Ribosomal protein S10 domain] -- -- A0A8B9WJJ7 Rh family C glycoprotein RHCG 5249432.08211496 31769444.5 0.1652352493011 0.00104845251329388 -2.59740660808632 down 3 Molecular Function:ammonium transmembrane transporter activity (GO:0008519),Biological Process:ammonium transport (GO:0015696),Cellular Component:membrane (GO:0016020) ammonium transporter Rh -- -- Ammonium transporter RHBG UR Intracellular trafficking, secretion, and vesicular transport ; General function prediction only ; IPR024041 [Ammonium transporter AmtB-like domain] plasma membrane protein -- A0A8B9X825 RNA helicase DHX9 4106629.53523144 11600322 0.354009960691733 0.0479876293958126 -1.49813814125028 down 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase A 3.6.4.13 -- Dosage compensation complex, subunit MLE K Transcription ; IPR001650 [Helicase, C-terminal] ; IPR007502 [Helicase-associated domain] ; IPR011545 [DEAD/DEAH box helicase domain] ; IPR011709 [Domain of unknown function DUF1605] ; IPR014720 [Double-stranded RNA-binding domain] nucleus protein -- A0A8B9XIE7 HSPA (Hsp70) binding protein 1 HSPBP1 809322.723854595 3507177 0.230761870260496 0.00699710243311929 -2.11552323368808 down -- -- hsp70-interacting protein -- ko04141 Protein processing in endoplasmic reticulum Armadillo/beta-catenin-like repeat-containing protein O Posttranslational modification, protein turnover, chaperones ; IPR013918 [Nucleotide exchange factor Fes1] endoplasmic reticulum protein -- A0A8B9YU21 Ubiquitin-like domain-containing protein 14629280.909325 1196589.75 12.2258116529287 0.00272305130488533 3.61185834156057 up 5 Molecular Function:structural constituent of ribosome (GO:0003735),Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S30e -- ko03010 Ribosome Ubiquitin-like/40S ribosomal S30 protein fusion JO Translation, ribosomal structure and biogenesis ; Posttranslational modification, protein turnover, chaperones ; IPR000626 [Ubiquitin domain] ; IPR006846 [Ribosomal protein S30] extracell protein -- A0A8B9XAA2 Ribosomal protein S13/S15 N-terminal domain-containing protein 5191144.690477 863406.375 6.01240023329339 0.0210195603002726 2.58794104973473 up 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S13e -- ko03010 Ribosome 40S ribosomal protein S13 J Translation, ribosomal structure and biogenesis ; IPR012606 [Ribosomal protein S13/S15, N-terminal] -- -- A0A8B9YLW7 Basic leucine zipper and W2 domains 1 BZW1 139796912.87629 3672385.25 38.0670608772024 3.53891149647371e-05 5.25047127992876 up 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted translation factor, contains W2 domain J Translation, ribosomal structure and biogenesis ; IPR003307 [W2 domain] -- -- A0A8B9W8R5 Epoxide hydrolase 2 EPHX2 21473470.4477633 284143.15625 75.5727173976702 1.33500150382609e-06 6.23979359416154 up -- -- -- -- ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways ko04146 Peroxisome Soluble epoxide hydrolase I Lipid transport and metabolism ; IPR000073 [Alpha/beta hydrolase fold-1] peroxisome protein -- A0A8B9VZ49 Uncharacterized protein 984877.641860482 4450715.25 0.221285251142607 0.00562090172687338 -2.17602079744254 down -- -- -- -- -- -- -- -- -- -- -- A0A8B9X0B3 Metabolism of cobalamin associated A MMAA 257497.568442366 942016.5 0.27334719555588 0.016028801713078 -1.87119352080726 down -- -- LAO/AO transport system kinase 2.7.-.- -- -- -- -- -- -- -- A0A8B9XFQ4 SEC61 translocon alpha 1 subunit SEC61A1 3584679.17458442 562082.8125 6.37749295097761 0.0180802458994758 2.67298939922245 up 2 Biological Process:protein transport (GO:0015031),Cellular Component:membrane (GO:0016020) protein transport protein SEC61 subunit alpha -- ko03060 Protein export ko04141 Protein processing in endoplasmic reticulum ko04145 Phagosome Transport protein Sec61, alpha subunit UO Intracellular trafficking, secretion, and vesicular transport ; Posttranslational modification, protein turnover, chaperones ; IPR002208 [SecY/SEC61-alpha family] ; IPR019561 [Translocon Sec61/SecY, plug domain] endoplasmic reticulum protein -- A0A8B9WTA4 Complex 1 LYR protein domain-containing protein 36845497.3225225 4167444.75 8.84126833895578 0.00737239127024544 3.14425334869646 up -- -- LYR motif-containing protein 4 -- -- Uncharacterized conserved protein BCN92 A RNA processing and modification ; IPR008011 [Complex 1 LYR protein] -- -- A0A8B9YLE6 Spermatogenesis associated 3 SPATA3 1714033.94631622 10873224 0.157638060828713 0.000779840464117665 -2.66531218738098 down -- -- -- -- -- -- -- -- IPR026717 [Spermatogenesis-associated protein 3] -- -- A0A8B9Y0K3 Ribosomal protein S5 RPS5 11727225.7211882 1569936.5 7.46987264847222 0.0118685115114236 2.90108364716662 up -- -- small subunit ribosomal protein S5e -- ko03010 Ribosome Ribosomal protein S7 J Translation, ribosomal structure and biogenesis ; IPR023798 [Ribosomal protein S7 domain] -- -- A0A8B9Y584 Ribosomal protein L39 2863581.92862159 262231 10.9200740134522 0.00389973147321967 3.44891072939409 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L39e -- ko03010 Ribosome 60s ribosomal protein L39 J Translation, ribosomal structure and biogenesis ; IPR000077 [Ribosomal protein L39e] -- -- A0A8B9YE27 Histone H2B 2042626.55817528 7434224.5 0.274759870135114 0.0164155454923213 -1.8637567871825 down 1 Molecular Function:DNA binding (GO:0003677) histone H2B -- ko05034 Alcoholism ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Histone H2B B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] nucleus protein -- A0A8B9W892 40S ribosomal protein S26 RPS26 13914031.3293651 1931237.625 7.20472258268327 0.013095846667186 2.84894288060233 up 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S26e -- ko03010 Ribosome 40s ribosomal protein S26 J Translation, ribosomal structure and biogenesis ; IPR000892 [Ribosomal protein S26e] -- -- A0A8B9WET0 Cytochrome c oxidase subunit 7A2 4725028.07236362 848325.6875 5.56982788802281 0.0254253778203169 2.47763274786471 up -- -- cytochrome c oxidase subunit 7a -- ko00190 Oxidative phosphorylation ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- -- mitochondrion protein -- A0A8B9Y0R2 Tctex1 domain-containing protein 2 12506997.9866884 2095581.5 5.96827085307272 0.0214138369871637 2.57731300970809 up -- -- -- -- -- Dynein light chain N Cell motility ; IPR005334 [Tctex-1] -- -- A0A8B9XRF9 Single-stranded DNA-binding protein SSBP1 1484527.92617065 27668404.375 0.053654265929119 1.23620296355336e-07 -4.22016330881873 down 1 Molecular Function:single-stranded DNA binding (GO:0003697) single-strand DNA-binding protein -- ko03030 DNA replication ko03430 Mismatch repair ko03440 Homologous recombination Single-stranded DNA-binding protein L Replication, recombination and repair ; IPR000424 [Primosome PriB/single-strand DNA-binding] mitochondrion protein -- A0A8B9X133 Testis-specific Y-encoded protein 3-like 279806.562731785 830060.5625 0.337091744112087 0.0395954559450805 -1.56878680092153 down 2 Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) TSPY-like 1 -- -- DNA replication factor/protein phosphatase inhibitor SET/SPR-2 L Replication, recombination and repair ; IPR002164 [Nucleosome assembly protein (NAP)] cytoplasm protein -- A0A8B9XJF4 Low molecular weight phosphotyrosine protein phosphatase 35347704.5479856 203350.265625 173.826694739463 1.26977100144579e-08 7.44150584506224 up -- -- -- -- ko00730 Thiamine metabolism ko00740 Riboflavin metabolism ko01100 Metabolic pathways Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR023485 [Phosphotyrosine protein phosphatase I superfamily] cytoplasm protein -- A0A8C0ALS5 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 6054273.66467864 570366.4375 10.6147088373843 0.00425910804458521 3.40799289339181 up 2 Molecular Function:nicotinate-nucleotide diphosphorylase (carboxylating) activity (GO:0004514),Biological Process:NAD biosynthetic process (GO:0009435) nicotinate-nucleotide pyrophosphorylase (carboxylating) 2.4.2.19 ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways Quinolinate phosphoribosyl transferase F Nucleotide transport and metabolism ; IPR002638 [Quinolinate phosphoribosyl transferase, C-terminal] ; IPR022412 [Quinolinate phosphoribosyl transferase, N-terminal] -- -- A0A8B9YIY3 Uncharacterized protein 1367208.45056449 13453007 0.101628464964338 3.49657959451422e-05 -3.29862355388695 down 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 3 subfamily A 1.14.14.1 ko00140 Steroid hormone biosynthesis ko00591 Linoleic acid metabolism ko00830 Retinol metabolism ko01100 Metabolic pathways ko05204 Chemical carcinogenesis Cytochrome P450 CYP3/CYP5/CYP6/CYP9 subfamilies Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] microsome protein -- A0A8B9X9D7 Transmembrane protein 132B TMEM132B 1204617.03205206 240903070.75 0.00500042207142376 6.13988459286812e-22 -7.6437344108446 down -- -- transmembrane protein 132 -- -- Uncharacterized conserved protein S Function unknown ; IPR031435 [Transmembrane protein TMEM132, N-terminal] ; IPR031436 [Transmembrane protein TMEM132, C-terminal] ; IPR031437 [Transmembrane protein family 132, middle domain] -- -- A0A8B9W9T5 Keratin 82 KRT82 16957587.5842721 1808378.375 9.37723422194324 0.0062014031875447 3.22916246829802 up 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444 [Keratin type II head] cytoplasm protein -- A0A8B9YPF8 Fibronectin type-II domain-containing protein 435308.598574157 1239135.75 0.351300169149471 0.0465837339832148 -1.50922382367566 down -- -- -- -- -- Gelatinase A and related matrix metalloproteases OW Posttranslational modification, protein turnover, chaperones ; Extracellular structures ; IPR000562 [Fibronectin, type II, collagen-binding] extracell protein -- A0A8C0A374 LIM and calponin homology domains 1 LIMCH1 1306414.68134538 4553844.5 0.286881706510923 0.0199796675299461 -1.80147211969615 down 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- FOG: LIM domain TZR Signal transduction mechanisms ; Cytoskeleton ; General function prediction only ; IPR001781 [Zinc finger, LIM-type] ; IPR031865 [Domain of unknown function DUF4757] cytoplasm protein --