{"text_format":"3","workbook":"xls","n_sheets":12,"sheets":["Table S1","Tabel S2","Table S3","Table S4","Table S5","Table S6","Table S7","Table S8","Table S9","Table S10","Table S11","Table S13"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table S1","index":0,"n_rows":22,"n_cols":3,"rows_kept":22,"merged":[[0,0,0,2]],"flags":["formulas_cached_only"]}
["Table S1 Size of library insert fragments"]
["Samples","Mean(bp)","Standard_deviation"]
["n_1",{"v":286.303867,"d":"286.30"},{"v":67.755456,"d":"67.76"}]
["n_2",{"v":285.345736,"d":"285.35"},{"v":67.643986,"d":"67.64"}]
["n_3",{"v":283.738623,"d":"283.74"},{"v":68.151932,"d":"68.15"}]
["n_4",{"v":284.641571,"d":"284.64"},{"v":70.509873,"d":"70.51"}]
["n_5",{"v":278.708685,"d":"278.71"},{"v":67.351847,"d":"67.35"}]
["n_9",{"v":286.481849,"d":"286.48"},{"v":69.537223,"d":"69.54"}]
["n_10",{"v":277.29452,"d":"277.29"},{"v":67.467151,"d":"67.47"}]
["n_11",{"v":276.875746,"d":"276.88"},{"v":67.735657,"d":"67.74"}]
["n_12",{"v":292.907646,"d":"292.91"},{"v":69.641282,"d":"69.64"}]
["n_13",{"v":295.543661,"d":"295.54"},{"v":70.618673,"d":"70.62"}]
["n_20",{"v":289.856762,"d":"289.86"},{"v":68.685931,"d":"68.69"}]
["n_21",{"v":298.668708,"d":"298.67"},{"v":72.680238,"d":"72.68"}]
["n_22",{"v":303.490443,"d":"303.49"},{"v":74.045387,"d":"74.05"}]
["n_23",{"v":312.953055,"d":"312.95"},{"v":73.351935,"d":"73.35"}]
["n_24",{"v":305.304869,"d":"305.30"},{"v":75.779329,"d":"75.78"}]
["n_25",{"v":307.990682,"d":"307.99"},{"v":75.83427,"d":"75.83"}]
["n_26",{"v":300.613407,"d":"300.61"},{"v":72.630039,"d":"72.63"}]
["n_27",{"v":307.60963,"d":"307.61"},{"v":71.854489,"d":"71.85"}]
["n_29",{"v":296.11278,"d":"296.11"},{"v":70.591592,"d":"70.59"}]
["n_30",{"v":295.373776,"d":"295.37"},{"v":67.233351,"d":"67.23"}]

{"sheet":"Tabel S2","index":1,"n_rows":22,"n_cols":9,"rows_kept":22,"merged":[[0,0,0,7]],"flags":["formulas_cached_only"]}
["Table S2 Summary of QC for sequencing data "]
["Samples","Raw_reads","Clean_reads","Clean_bases","Error_rate(%)","Q20","Q30","GC content percentage(%)","Groups"]
["n_1",35172806,34342352,"5.15G",0.03,95.97,89.82,50.48,"ppm5.4"]
["n_2",27543252,26867400,"4.03G",0.03,96.41,90.65,50.56,"ppm5.4"]
["n_3",35311980,34455980,"5.17G",0.03,95.69,89.3,50.53,"ppm5.4"]
["n_4",34371024,33471888,"5.02G",0.03,96.03,89.93,50.26,"ppm5.4"]
["n_5",32480592,31532190,"4.73G",0.03,95.95,89.78,50.65,"ppm5.4"]
["n_9",37223604,36264266,"5.44G",0.03,96.41,90.85,50.39,"ppm4"]
["n_10",39535874,38469782,"5.77G",0.03,96.04,89.94,50.55,"ppm4"]
["n_11",28767388,27880526,"4.18G",0.03,95.83,89.49,50.31,"ppm4"]
["n_12",33750904,32664218,"4.9G",0.03,95.64,89.21,50.62,"ppm4"]
["n_13",43296630,42106188,"6.32G",0.03,96.88,91.82,50.64,"ppm4"]
["n_20",38891992,37737572,"5.66G",0.03,95.91,89.72,50.13,"ppm2"]
["n_21",27677998,26898948,"4.03G",0.03,96.03,89.99,50.43,"ppm2"]
["n_22",37516050,36364158,"5.45G",0.03,95.78,89.47,50.65,"ppm2"]
["n_23",45219420,44192324,"6.63G",0.03,96.58,91.25,50.8,"ppm2"]
["n_24",32948434,31959270,"4.79G",0.03,96.16,90.18,50.4,"ppm2"]
["n_25",28870752,28065146,"4.21G",0.03,95.94,89.78,50.46,"ppm0"]
["n_26",46076896,44482238,"6.67G",0.03,95.87,89.63,50.77,"ppm0"]
["n_27",31786336,31014154,"4.65G",0.03,96.47,90.81,50.55,"ppm0"]
["n_29",28183118,27505654,"4.13G",0.03,96.34,90.56,50.36,"ppm0"]
["n_30",39616274,38789772,"5.82G",0.03,96.57,91.24,49.55,"ppm0"]

{"sheet":"Table S3","index":2,"n_rows":22,"n_cols":12,"rows_kept":22,"merged":[[0,0,0,11]],"flags":["formulas_cached_only"]}
["Table S3 Summary of mapping results "]
["Samples","Total_reads","Total_map","Unique_map","Multi_map","Read1_map","Read2_map","Positive_map","Negative_map","Splice_map","Unsplice_map","Proper_map"]
["n_1",34342352,"31783440(92.55%)","30884085(89.93%)","899355(2.62%)","15567333(45.33%)","15316752(44.6%)","15423914(44.91%)","15460171(45.02%)","12459246(36.28%)","18424839(53.65%)","29364348(85.5%)"]
["n_2",26867400,"24996533(93.04%)","24286268(90.39%)","710265(2.64%)","12196945(45.4%)","12089323(45.0%)","12127568(45.14%)","12158700(45.25%)","9878026(36.77%)","14408242(53.63%)","23168714(86.23%)"]
["n_3",34455980,"31803571(92.3%)","30882646(89.63%)","920925(2.67%)","15588763(45.24%)","15293883(44.39%)","15418395(44.75%)","15464251(44.88%)","12727057(36.94%)","18155589(52.69%)","29307524(85.06%)"]
["n_4",33471888,"30963550(92.51%)","30089734(89.9%)","873816(2.61%)","15104030(45.12%)","14985704(44.77%)","15027391(44.9%)","15062343(45.0%)","12186985(36.41%)","17902749(53.49%)","28553640(85.31%)"]
["n_5",31532190,"29195460(92.59%)","28341170(89.88%)","854290(2.71%)","14303233(45.36%)","14037937(44.52%)","14152559(44.88%)","14188611(45.0%)","11682794(37.05%)","16658376(52.83%)","26962392(85.51%)"]
["n_9",36264266,"33603420(92.66%)","32668488(90.08%)","934932(2.58%)","16430236(45.31%)","16238252(44.78%)","16315121(44.99%)","16353367(45.09%)","13136069(36.22%)","19532419(53.86%)","31058674(85.65%)"]
["n_10",38469782,"35627860(92.61%)","34601810(89.95%)","1026050(2.67%)","17402574(45.24%)","17199236(44.71%)","17281672(44.92%)","17320138(45.02%)","14203179(36.92%)","20398631(53.03%)","32906994(85.54%)"]
["n_11",27880526,"25794559(92.52%)","25052779(89.86%)","741780(2.66%)","12651399(45.38%)","12401380(44.48%)","12508995(44.87%)","12543784(44.99%)","10017324(35.93%)","15035455(53.93%)","23789826(85.33%)"]
["n_12",32664218,"30093635(92.13%)","29214251(89.44%)","879384(2.69%)","14810572(45.34%)","14403679(44.1%)","14587501(44.66%)","14626750(44.78%)","11901694(36.44%)","17312557(53.0%)","27639560(84.62%)"]
["n_13",42106188,"39176090(93.04%)","38054228(90.38%)","1121862(2.66%)","19097378(45.36%)","18956850(45.02%)","19007873(45.14%)","19046355(45.23%)","15571114(36.98%)","22483114(53.4%)","36250092(86.09%)"]
["n_20",37737572,"34969974(92.67%)","33966643(90.01%)","1003331(2.66%)","17145102(45.43%)","16821541(44.58%)","16961677(44.95%)","17004966(45.06%)","13458138(35.66%)","20508505(54.35%)","32285360(85.55%)"]
["n_21",26898948,"24871455(92.46%)","24180189(89.89%)","691266(2.57%)","12171186(45.25%)","12009003(44.64%)","12077280(44.9%)","12102909(44.99%)","9782195(36.37%)","14397994(53.53%)","22925564(85.23%)"]
["n_22",36364158,"33603105(92.41%)","32636006(89.75%)","967099(2.66%)","16477822(45.31%)","16158184(44.43%)","16301514(44.83%)","16334492(44.92%)","13706207(37.69%)","18929799(52.06%)","30888452(84.94%)"]
["n_23",44192324,"41089061(92.98%)","39900264(90.29%)","1188797(2.69%)","20116546(45.52%)","19783718(44.77%)","19928012(45.09%)","19972252(45.19%)","16685982(37.76%)","23214282(52.53%)","37947922(85.87%)"]
["n_24",31959270,"29592337(92.59%)","28765014(90.01%)","827323(2.59%)","14467765(45.27%)","14297249(44.74%)","14363791(44.94%)","14401223(45.06%)","11598733(36.29%)","17166281(53.71%)","27261362(85.3%)"]
["n_25",28065146,"25965458(92.52%)","25243215(89.95%)","722243(2.57%)","12722838(45.33%)","12520377(44.61%)","12606670(44.92%)","12636545(45.03%)","10421577(37.13%)","14821638(52.81%)","23910078(85.19%)"]
["n_26",44482238,"41161081(92.53%)","39987615(89.9%)","1173466(2.64%)","20182173(45.37%)","19805442(44.52%)","19970391(44.9%)","20017224(45.0%)","16943611(38.09%)","23044004(51.8%)","37914124(85.23%)"]
["n_27",31014154,"28873474(93.1%)","28067419(90.5%)","806055(2.6%)","14151973(45.63%)","13915446(44.87%)","14021178(45.21%)","14046241(45.29%)","11494502(37.06%)","16572917(53.44%)","26719592(86.15%)"]
["n_29",27505654,"25516594(92.77%)","24805364(90.18%)","711230(2.59%)","12491860(45.42%)","12313504(44.77%)","12388947(45.04%)","12416417(45.14%)","10040577(36.5%)","14764787(53.68%)","23581444(85.73%)"]
["n_30",38789772,"35910540(92.58%)","34928721(90.05%)","981819(2.53%)","17598049(45.37%)","17330672(44.68%)","17444978(44.97%)","17483743(45.07%)","12317122(31.75%)","22611599(58.29%)","33228906(85.66%)"]

{"sheet":"Table S4","index":3,"n_rows":22,"n_cols":4,"rows_kept":22,"merged":[[0,0,0,3]],"flags":["formulas_cached_only"]}
[" Table S4 Distribution of aligned reads in Takifugu rubripes genomes."]
["Samples","Exon","Intron","Intergenic"]
["n_1","3767107198(79.3068%)","361063423(7.6013%)","621876964(13.092%)"]
["n_2","2982577890(79.8434%)","280024748(7.4962%)","472931063(12.6603%)"]
["n_3","3834449505(80.6741%)","309607483(6.5139%)","608955672(12.812%)"]
["n_4","3702930641(80.0296%)","309010259(6.6785%)","615005611(13.2918%)"]
["n_5","3492291245(80.0454%)","314621560(7.2113%)","555975785(12.7433%)"]
["n_9","3996533406(79.5812%)","361793182(7.2042%)","663630820(13.2146%)"]
["n_10","4293351899(80.6373%)","358719445(6.7374%)","672207640(12.6253%)"]
["n_11","3067670102(79.5868%)","270743381(7.0241%)","516083565(13.3891%)"]
["n_12","3597450980(79.994%)","322966562(7.1816%)","576734549(12.8244%)"]
["n_13","4662742464(79.6342%)","432192629(7.3813%)","760267328(12.9845%)"]
["n_20","4216683387(80.6867%)","301795136(5.7749%)","707512550(13.5383%)"]
["n_21","2954124039(79.481%)","285185157(7.6729%)","477458807(12.8461%)"]
["n_22","4084874083(81.3439%)","309228479(6.1578%)","627631635(12.4983%)"]
["n_23","4968078507(80.8888%)","386451430(6.2921%)","787334209(12.8191%)"]
["n_24","3518083685(79.5529%)","329058796(7.4409%)","575179322(13.0063%)"]
["n_25","3118431795(80.3654%)","269626792(6.9486%)","492256005(12.686%)"]
["n_26","4966156781(80.7298%)","426865900(6.9391%)","758560109(12.3311%)"]
["n_27","3438675554(79.6833%)","316755361(7.3401%)","559993192(12.9766%)"]
["n_29","3047807956(79.9236%)","274235766(7.1914%)","491355985(12.885%)"]
["n_30","4157745081(77.4805%)","400590321(7.4651%)","807847419(15.0544%)"]

{"sheet":"Table S5","index":4,"n_rows":22,"n_cols":6,"rows_kept":22,"merged":[[0,0,0,5]],"flags":["formulas_cached_only"]}
["Table S5 Quality control of sequencing after mapping to references"]
["Samples","Percent of duplicates","GC content percentage","Average sequence length","Total aligned reads(M)","Unique aligned reads(M)"]
["n_1",{"v":0.181,"d":"18.10%"},{"v":0.5,"d":"50.00%"},"134 bp",29.7,{"v":24.324300000000004,"d":"24.3"}]
["n_10",{"v":0.188,"d":"18.80%"},{"v":0.5,"d":"50.00%"},"134 bp",32.1,{"v":26.0652,"d":"26.1"}]
["n_11",{"v":0.163,"d":"16.30%"},{"v":0.5,"d":"50.00%"},"134 bp",{"v":24,"d":"24.0"},{"v":20.088,"d":"20.1"}]
["n_12",{"v":0.174,"d":"17.40%"},{"v":0.5,"d":"50.00%"},"134 bp",28.3,{"v":23.375799999999998,"d":"23.4"}]
["n_13",{"v":0.206,"d":"20.60%"},{"v":0.5,"d":"50.00%"},"134 bp",35.5,{"v":28.187,"d":"28.2"}]
["n_2",{"v":0.158,"d":"15.80%"},{"v":0.5,"d":"50.00%"},"134 bp",23.6,{"v":19.8712,"d":"19.9"}]
["n_20",{"v":0.182,"d":"18.20%"},{"v":0.5,"d":"50.00%"},"134 bp",{"v":31,"d":"31.0"},{"v":25.357999999999997,"d":"25.4"}]
["n_21",{"v":0.158,"d":"15.80%"},{"v":0.5,"d":"50.00%"},"134 bp",{"v":23,"d":"23.0"},{"v":19.366,"d":"19.4"}]
["n_22",{"v":0.179,"d":"17.90%"},{"v":0.5,"d":"50.00%"},"134 bp",30.6,{"v":25.1226,"d":"25.1"}]
["n_23",{"v":0.209,"d":"20.90%"},{"v":0.5,"d":"50.00%"},"134 bp",36.5,{"v":28.871499999999997,"d":"28.9"}]
["n_24",{"v":0.174,"d":"17.40%"},{"v":0.5,"d":"50.00%"},"134 bp",27.8,{"v":22.962799999999998,"d":"23.0"}]
["n_25",{"v":0.16,"d":"16.00%"},{"v":0.5,"d":"50.00%"},"134 bp",23.8,{"v":19.992,"d":"20.0"}]
["n_26",{"v":0.197,"d":"19.70%"},{"v":0.5,"d":"50.00%"},"134 bp",36.3,{"v":29.148899999999998,"d":"29.1"}]
["n_27",{"v":0.171,"d":"17.10%"},{"v":0.5,"d":"50.00%"},"134 bp",25.4,{"v":21.0566,"d":"21.1"}]
["n_29",{"v":0.155,"d":"15.50%"},{"v":0.5,"d":"50.00%"},"134 bp",22.5,{"v":19.0125,"d":"19.0"}]
["n_3",{"v":0.177,"d":"17.70%"},{"v":0.5,"d":"50.00%"},"134 bp",{"v":29,"d":"29.0"},{"v":23.866999999999997,"d":"23.9"}]
["n_30",{"v":0.198,"d":"19.80%"},{"v":0.49,"d":"49.00%"},"134 bp",31.7,{"v":25.4234,"d":"25.4"}]
["n_4",{"v":0.174,"d":"17.40%"},{"v":0.5,"d":"50.00%"},"134 bp",27.8,{"v":22.962799999999998,"d":"23.0"}]
["n_5",{"v":0.173,"d":"17.30%"},{"v":0.5,"d":"50.00%"},"134 bp",27.4,{"v":22.6598,"d":"22.7"}]
["n_9",{"v":0.185,"d":"18.50%"},{"v":0.5,"d":"50.00%"},"134 bp",30.8,{"v":25.102000000000004,"d":"25.1"}]

{"sheet":"Table S6","index":5,"n_rows":22,"n_cols":3,"rows_kept":22,"merged":[[0,0,0,2]],"flags":["formulas_cached_only"]}
["Table S6 Summary of the reads in exons of Takifugu rubripes counted by HTSeq"]
["Samples","Percent of Assigned Reads","Numberof Assigned reads (M)"]
["n_1",{"v":0.76,"d":"76.0%"},10.4]
["n_10",{"v":0.762,"d":"76.2%"},11.3]
["n_11",{"v":0.761,"d":"76.1%"},8.4]
["n_12",{"v":0.759,"d":"75.9%"},9.9]
["n_13",{"v":0.759,"d":"75.9%"},12.3]
["n_2",{"v":0.761,"d":"76.1%"},8.3]
["n_20",{"v":0.766,"d":"76.6%"},10.9]
["n_21",{"v":0.758,"d":"75.8%"},8]
["n_22",{"v":0.768,"d":"76.8%"},10.8]
["n_23",{"v":0.768,"d":"76.8%"},12.9]
["n_24",{"v":0.761,"d":"76.1%"},9.8]
["n_25",{"v":0.765,"d":"76.5%"},8.4]
["n_26",{"v":0.763,"d":"76.3%"},12.7]
["n_27",{"v":0.76,"d":"76.0%"},8.9]
["n_29",{"v":0.753,"d":"75.3%"},7.8]
["n_3",{"v":0.762,"d":"76.2%"},10.2]
["n_30",{"v":0.746,"d":"74.6%"},10.9]
["n_4",{"v":0.759,"d":"75.9%"},9.7]
["n_5",{"v":0.764,"d":"76.4%"},9.6]
["n_9",{"v":0.76,"d":"76.0%"},10.8]

{"sheet":"Table S7","index":6,"n_rows":10,"n_cols":3,"rows_kept":10,"merged":[[0,0,0,2],[9,0,9,2]],"flags":["formulas_cached_only"]}
["Table S7 Primers for quantitative real-time PCR."]
["Gene Name","Primer Sequences","Product Size(bp)"]
["chn1","F:5’ GCCAATGACTGTAAACCCAACC 3’\nR:5’ AGACCCTCAGACCTGAGCCC 3’",152]
["pcdh17","F:5’ CGTGGACAACGATTACGGTGA 3’\nR:5’ AGTGTTGGCTTGCCGTGGT 3’",183]
["LOC101069872","F:5’ TCCTCAACTTTAACCCGCACTT 3’\nR:5’ GGAACCCGTCTTGTATATTTCGTA 3’",233]
["foxo3","F:5’ TCGGGTCCCTTAAAGTGGC 3’\nR:5’ TGACTGTGCTGGCATTGGAA 3’",106]
["hif1an","F:5’ CTAAAGTGGGACATCGCATACCT 3’\nR:5’ GGGACGTTGGGACAAAGTTCT 3’",136]
["angptl4","F:5’ TGGACAGTGATACAGAGACGCC 3’\nR:5’ TGGATGTTCAGGATGTAGCCG 3’",158]
["actb","F:5’ AAATCGTGCGTGACATCAAGG 3’\nR:5’ GATTCCACAGGACTCCATACCAAG 3’",203]
["Note: F: forward primers; R: reverse primers; actb was used as reference."]

{"sheet":"Table S8","index":7,"n_rows":169,"n_cols":4,"rows_kept":169,"merged":[[0,0,0,2]],"flags":["formulas_cached_only"]}
["Table S8 List of DEGs",null,null," "]
["Gene ID","Symbols","Annotations"," "]
["LOC115251571","abcf4","ABC transporter F family member 4-like"," "]
["LOC101072243","abcg2","ATP-binding cassette sub-family G member 2-like transcript variant X2"," "]
["acadl","acadl","acyl-CoA dehydrogenase long chain"," "]
["ackr4","ackr4","atypical chemokine receptor 4"," "]
["acsl3","acsl3","acyl-CoA synthetase long chain family member 3 transcript variant X2"," "]
["acta2","acta2","actin alpha 2 smooth muscle transcript variant X1"," "]
["adora2b","adora2b","adenosine A2b receptor transcript variant X1"," "]
["angptl4","angptl4","angiopoietin like 4"," "]
["ano5","ano5","anoctamin 5 transcript variant X1"," "]
["apba2","apba2","amyloid beta precursor protein binding family A member 2 transcript variant X2"," "]
["b3gat2","b3gat2","beta-13-glucuronyltransferase 2"," "]
["LOC101063749","bhlhe40","class E basic helix-loop-helix protein 40-like"," "]
["c2cd4c","c2cd4c","C2 calcium dependent domain containing 4C"," "]
["LOC101074165","ca4","carbonic anhydrase 4-like transcript variant X1"," "]
["LOC101061156","cables2","CDK5 and ABL1 enzyme substrate 2-like"," "]
["cad","cad","carbamoyl-phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase"," "]
["cd79b","cd79b","CD79b molecule"," "]
["LOC115248482","cd81","CD81 antigen-like"," "]
["LOC101068040","cdc14a","dual specificity protein phosphatase CDC14A transcript variant X2"," "]
["cdcp2","cdcp2","CUB domain containing protein 2"," "]
["LOC115248349","chchd1","coiled-coil-helix-coiled-coil-helix domain-containing protein 1-like"," "]
["LOC101076158","cnn2","calponin-2"," "]
["coq8b","coq8a","coenzyme Q8B transcript variant X1"," "]
["LOC101072059","cry1","cryptochrome-1-like"," "]
["LOC101074542","cyp1a1","cytochrome P450 1A1-like"," "]
["LOC101079203","ddit4","DNA damage-inducible transcript 4 protein-like"," "]
["LOC101061262","dnajb5","dnaJ homolog subfamily B member 5-like"," "]
["LOC101064836","dtx3","probable E3 ubiquitin-protein ligase DTX3 transcript variant X2"," "]
["LOC101079172","dusp2","dual specificity protein phosphatase 2-like"," "]
["LOC101061562","dusp4","dual specificity protein phosphatase 4"," "]
["dusp5","dusp5","dual specificity phosphatase 5"," "]
["LOC101063916","efl1","elongation factor-like GTPase 1"," "]
["egfl7","egfl7","EGF like domain multiple 7 transcript variant X1"," "]
["LOC101071669","egln2","egl nine homolog 2-like transcript variant X1"," "]
["egr1","egr1","early growth response 1"," "]
["LOC101064926","egr1","early growth response protein 1-B-like"," "]
["LOC115250832","egr1","early growth response protein 1-like"," "]
["LOC101072057","egr2","E3 SUMO-protein ligase EGR2-like"," "]
["epha4","epha4","EPH receptor A4"," "]
["LOC101067410","ephb3","ephrin type-B receptor 3-like transcript variant X1"," "]
["LOC101063319","erc1","ELKS/Rab6-interacting/CAST family member 1-like transcript variant X1"," "]
["esrra","esrra","estrogen related receptor alpha transcript variant X1"," "]
["LOC115253183","f8a3","factor VIII intron 22 protein-like"," "]
["LOC101072747","fbxo28","F-box only protein 28"," "]
["LOC115250686","fndc4","fibronectin type III domain-containing protein 4-like transcript variant X4"," "]
["LOC101068404","fos","proto-oncogene c-Fos transcript variant X1"," "]
["LOC101078177","fos","proto-oncogene c-Fos-like transcript variant X1"," "]
["fosb","fosb","FosB proto-oncogene AP-1 transcription factor subunit transcript variant X2"," "]
["fosl2","fosl2","FOS like 2 AP-1 transcription factor subunit"," "]
["LOC115249702","foxg1","forkhead box protein G1-like"," "]
["foxk1","foxk1","forkhead box K1 transcript variant X1"," "]
["foxo3","foxo3","forkhead box O3 transcript variant X1"," "]
["LOC105418832","fscb","fibrous sheath CABYR-binding protein-like transcript variant X1"," "]
["ghr","ghr","growth hormone receptor transcript variant X1"," "]
["gje1","gje1","gap junction protein epsilon 1 transcript variant X2"," "]
["LOC115250699","gpr12","G-protein coupled receptor 12-like"," "]
["gpr156","gpr156","G protein-coupled receptor 156 transcript variant X1"," "]
["gpr19","gpr19","G protein-coupled receptor 19 transcript variant X1"," "]
["LOC101063882","gpr3","G-protein coupled receptor 3"," "]
["gprc5c","gprc5c","G protein-coupled receptor class C group 5 member C transcript variant X1"," "]
["LOC105417378","havcr1","hepatitis A virus cellular receptor 1 homolog transcript variant X2"," "]
["LOC101067611","hcn1","potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1"," "]
["hic1","hic1","HIC ZBTB transcriptional repressor 1 transcript variant X2"," "]
["hif1an","hif1an","hypoxia inducible factor 1 subunit alpha inhibitor"," "]
["LOC101079462","hk2","glucokinase-like"," "]
["LOC101068247","hlf","hepatic leukemia factor-like"," "]
["hlf","hlf","HLF transcription factor PAR bZIP family member"," "]
["hopx","hopx","HOP homeobox"," "]
["LOC101064958","hsd11b2","corticosteroid 11-beta-dehydrogenase isozyme 2-like transcript variant X2"," "]
["ier2","ier2","immediate early response 2"," "]
["LOC101077635","inhbb","inhibin beta B chain-like"," "]
["itga4","itga4","integrin subunit alpha 4"," "]
["itga8","itga8","integrin subunit alpha 8"," "]
["LOC101077059","jun","transcription factor AP-1"," "]
["jund","jund","JunD proto-oncogene AP-1 transcription factor subunit"," "]
["kcp","kcp","kielin cysteine rich BMP regulator"," "]
["kdm3b","kdm3b","lysine demethylase 3B transcript variant X4"," "]
["LOC101069859","kdm5b","lysine-specific demethylase 5B"," "]
["flt1","flt1","fms related receptor tyrosine kinase 1"," "]
["kiaa0895","kiaa0895","KIAA0895 ortholog transcript variant X2"," "]
["LOC101067844","klf13","Krueppel-like factor 13"," "]
["LOC101071677","lnx2","ligand of Numb protein X 2-like transcript variant X1"," "]
["LOC105418156","loc105418156","uncharacterized LOC105418156 transcript variant X2"," "]
["LOC115248067","iglc3","Ig lambda-3 chain C region-like"," "]
["LOC101065116","lonrf2","LON peptidase N-terminal domain and RING finger protein 2"," "]
["LOC115247560","lsm1","U6 snRNA-associated Sm-like protein LSm1"," "]
["LOC101067897","maff","transcription factor MafF-like"," "]
["map3k13","map3k13","mitogen-activated protein kinase kinase kinase 13 transcript variant X3"," "]
["LOC105417022","map7d2","MAP7 domain-containing protein 2-like transcript variant X4"," "]
["LOC115251353","map7d2","MAP7 domain-containing protein 2-like"," "]
["mapk4","mapk4","mitogen-activated protein kinase 4 transcript variant X4"," "]
["mecom","mecom","MDS1 and EVI1 complex locus transcript variant X1"," "]
["LOC101078722","mex3b","RNA-binding protein MEX3B-like"," "]
["LOC101062434","midn","midnolin-A transcript variant X4"," "]
["mmel1","mmel1","membrane metalloendopeptidase like 1"," "]
["LOC115252113","mtch2","mitochondrial carrier homolog 2-like"," "]
["nab2","nab2","NGFI-A binding protein 2 transcript variant X3"," "]
["nck2","nck2","NCK adaptor protein 2"," "]
["ndst1","ndst1","N-deacetylase and N-sulfotransferase 1 transcript variant X1"," "]
["nefl","nefl","neurofilament light"," "]
["nefm","nefm","neurofilament medium transcript variant X1"," "]
["LOC101077658","nfil3","uncharacterized LOC101077658"," "]
["nipal2","nipal2","NIPA like domain containing 2 transcript variant X3"," "]
["nkd2","nkd2","NKD inhibitor of WNT signaling pathway 2 transcript variant X2"," "]
["npas1","npas1","neuronal PAS domain protein 1 transcript variant X7"," "]
["npas4","npas4","neuronal PAS domain protein 4"," "]
["npy8br","npy8br","neuropeptide Y/peptide YY receptor Npy8br transcript variant X1"," "]
["nr4a3","nr4a3","nuclear receptor subfamily 4 group A member 3 transcript variant X3"," "]
["ntng1","ntng1","netrin G1 transcript variant X7"," "]
["LOC101072056","olfm2","noelin-2-like transcript variant X1"," "]
["LOC101062943","osgin2","oxidative stress-induced growth inhibitor 2-like"," "]
["p4ha1","p4ha1","prolyl 4-hydroxylase subunit alpha 1 transcript variant X2"," "]
["LOC101062387","pan1","actin cytoskeleton-regulatory complex protein PAN1-like transcript variant X2"," "]
["LOC115246671","parp12","protein mono-ADP-ribosyltransferase PARP12-like transcript variant X2"," "]
["pax5","pax5","paired box 5 transcript variant X3"," "]
["pcdh17","pcdh17","protocadherin 17 transcript variant X2"," "]
["pcsk5","pcsk5","proprotein convertase subtilisin/kexin type 5 transcript variant X2"," "]
["LOC101064308","pcyt2","ethanolamine-phosphate cytidylyltransferase-like transcript variant X1"," "]
["phactr4","phactr4","phosphatase and actin regulator 4 transcript variant X6"," "]
["LOC101061919","pmp22","peripheral myelin protein 22-like"," "]
["LOC101073585","ppdpf","pancreatic progenitor cell differentiation and proliferation factor A-like"," "]
["LOC115253280","prdm9","histone-lysine N-methyltransferase PRDM9-like transcript variant X1"," "]
["LOC101066219","prelid3b","PRELI domain containing protein 3B-like"," "]
["prex2","prex2","phosphatidylinositol-345-trisphosphate dependent Rac exchange factor 2 transcript variant X1"," "]
["prickle3","prickle3","prickle planar cell polarity protein 3 transcript variant X1"," "]
["prtg","prtg","protogenin"," "]
["LOC101061866","ptprb","protein tyrosine phosphatase receptor type B transcript variant X5"," "]
["ptprb","ptprb","protein tyrosine phosphatase receptor type B"," "]
["LOC101074924","rasd1","dexamethasone-induced Ras-related protein 1-like"," "]
["LOC101066986","rasgef1b","ras-GEF domain-containing family member 1B-B-like"," "]
["rbpms2","rbpms2","RNA binding protein mRNA processing factor 2 transcript variant X1"," "]
["LOC101078500","rgs18","regulator of G protein signaling 18 transcript variant X1"," "]
["LOC101074055","rin2","ras and Rab interactor 2 transcript variant X1"," "]
["LOC101070652","rnd1","rho-related GTP-binding protein Rho6-like"," "]
["LOC101067156","rsbn1","lysine-specific demethylase 9"," "]
["rtn4rl2","rtn4rl2","reticulon 4 receptor like 2"," "]
["rxra","rxra","retinoid X receptor alpha transcript variant X2"," "]
["LOC101065219","s100a1","protein S100-A1-like"," "]
["sc5d","sc5d","sterol-C5-desaturase"," "]
["LOC101068254","scn4b","sodium channel subunit beta-4-like"," "]
["sema5b","sema5b","semaphorin 5B transcript variant X2"," "]
["LOC101065940","sh2d3c","SH2 domain-containing protein 3C-like transcript variant X1"," "]
["LOC101075091","sh2d4a","SH2 domain-containing protein 4A-like transcript variant X2"," "]
["sla","sla","Src like adaptor"," "]
["mct4b","slc16a3","monocarboxylate transporter 4b transcript variant X1"," "]
["LOC105416362","slc18a3","probable vesicular acetylcholine transporter-A transcript variant X1"," "]
["LOC101071892","slc1a5","neutral amino acid transporter B(0)"," "]
["LOC101063282","slc2a1","solute carrier family 2 facilitated glucose transporter member 1-like"," "]
["LOC101077095","slc38a3","sodium-coupled neutral amino acid transporter 3 transcript variant X2"," "]
["LOC101079523","slc43a2","large neutral amino acids transporter small subunit 4-like"," "]
["slc8b1","slc8b1","solute carrier family 8 member B1"," "]
["LOC101061569","slco3a1","solute carrier organic anion transporter family member 3A1-like"," "]
["smad7","smad7","SMAD family member 7 transcript variant X2"," "]
["soga1","soga1","suppressor of glucose autophagy associated 1 transcript variant X2"," "]
["susd1","susd1","sushi domain containing 1 transcript variant X1"," "]
["LOC115252109","syap1","synapse-associated protein 1-like"," "]
["LOC101067578","taf4","transcription initiation factor TFIID subunit 4-like transcript variant X1"," "]
["LOC101061097","tfe3","transcription factor E3"," "]
["LOC101068527","tlr2","toll-like receptor 2 transcript variant X1"," "]
["LOC101073940","tpst1","protein-tyrosine sulfotransferase 1"," "]
["LOC101068010","ttc9","tetratricopeptide repeat protein 9A"," "]
["LOC101068092","ugt2a2","UDP-glucuronosyltransferase 2A2-like transcript variant X2"," "]
["vegfa","vegfa","vascular endothelial growth factor A transcript variant X1"," "]
["LOC101070310","yaf2","YY1-associated factor 2 transcript variant X1"," "]
["LOC101073528","zbtb16","zinc finger and BTB domain-containing protein 16-A-like"," "]
["zbtb18","zbtb18","zinc finger and BTB domain containing 18 transcript variant X3"," "]
["LOC101077219","znf292","zinc finger protein 292-like"," "]

{"sheet":"Table S9","index":8,"n_rows":90,"n_cols":9,"rows_kept":90,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["Table S9 Results of the enrichment analysis of the KEGG pathway"]
["ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count"]
["hsa04010","MAPK signaling pathway","10/79","294/8104",{"v":0.000531377660207597,"d":"0.001"},{"v":0.0500067452268019,"d":"0.050"},{"v":0.0458829128734518,"d":"0.046"},"1844/1846/1847/2122/2321/2353/3725/3727/7422/9175",10]
["hsa05211","Renal cell carcinoma","5/79","69/8104",{"v":0.000534831499751892,"d":"0.001"},{"v":0.0500067452268019,"d":"0.050"},{"v":0.0458829128734518,"d":"0.046"},"112398/3725/6513/7030/7422",5]
["hsa05323","Rheumatoid arthritis","5/79","93/8104",{"v":0.00206250193852639,"d":"0.002"},{"v":0.10107262659784,"d":"0.101"},{"v":0.0927376196760363,"d":"0.093"},"2321/2353/3725/7097/7422",5]
["hsa04657","IL-17 signaling pathway","5/79","94/8104",{"v":0.00216198131760085,"d":"0.002"},{"v":0.10107262659784,"d":"0.101"},{"v":0.0927376196760363,"d":"0.093"},"2353/2354/3725/3727/5596",5]
["hsa04066","HIF-1 signaling pathway","5/79","109/8104",{"v":0.00410920109300232,"d":"0.004"},{"v":0.131964260551214,"d":"0.132"},{"v":0.121081758907109,"d":"0.121"},"112398/2321/3099/6513/7422",5]
["hsa05230","Central carbon metabolism in cancer","4/79","70/8104",{"v":0.00471305195841815,"d":"0.005"},{"v":0.131964260551214,"d":"0.132"},{"v":0.121081758907109,"d":"0.121"},"3099/6510/6513/9123",4]
["hsa03320","PPAR signaling pathway","4/79","76/8104",{"v":0.0063115222119183,"d":"0.006"},{"v":0.131964260551214,"d":"0.132"},{"v":0.121081758907109,"d":"0.121"},"2181/33/51129/6256",4]
["hsa05140","Leishmaniasis","4/79","77/8104",{"v":0.00660886814483908,"d":"0.007"},{"v":0.131964260551214,"d":"0.132"},{"v":0.121081758907109,"d":"0.121"},"2353/3676/3725/7097",4]
["hsa04151","PI3K-Akt signaling pathway","9/79","354/8104",{"v":0.00723677252433796,"d":"0.007"},{"v":0.131964260551214,"d":"0.132"},{"v":0.121081758907109,"d":"0.121"},"2309/2321/2690/3676/54541/6256/7097/7422/8516",9]
["hsa04380","Osteoclast differentiation","5/79","128/8104",{"v":0.00806630217990749,"d":"0.008"},{"v":0.131964260551214,"d":"0.132"},{"v":0.121081758907109,"d":"0.121"},"2353/2354/2355/3725/3727",5]
["hsa04662","B cell receptor signaling pathway","4/79","82/8104",{"v":0.00823538295697351,"d":"0.008"},{"v":0.131964260551214,"d":"0.132"},{"v":0.121081758907109,"d":"0.121"},"2353/3725/974/975",4]
["hsa04360","Axon guidance","6/79","182/8104",{"v":0.00846829479473031,"d":"0.008"},{"v":0.131964260551214,"d":"0.132"},{"v":0.121081758907109,"d":"0.121"},"2043/2049/22854/27289/54437/8440",6]
["hsa05202","Transcriptional misregulation in cancer","6/79","192/8104",{"v":0.0108619649770011,"d":"0.011"},{"v":0.15159355843692,"d":"0.152"},{"v":0.139092316494332,"d":"0.139"},"2321/5079/6256/7030/7704/8013",6]
["hsa04976","Bile secretion","4/79","90/8104",{"v":0.0113492503642614,"d":"0.011"},{"v":0.15159355843692,"d":"0.152"},{"v":0.139092316494332,"d":"0.139"},"6256/6513/7366/9429",4]
["hsa04928","Parathyroid hormone synthesis, secretion and action","4/79","106/8104",{"v":0.0196424181785024,"d":"0.020"},{"v":0.235495011874231,"d":"0.235"},{"v":0.216074792769489,"d":"0.216"},"1958/2353/3727/6256",4]
["hsa04964","Proximal tubule bicarbonate reclamation","2/79","23/8104",{"v":0.0207942577097916,"d":"0.021"},{"v":0.235495011874231,"d":"0.235"},{"v":0.216074792769489,"d":"0.216"},"10991/762",2]
["hsa00140","Steroid hormone biosynthesis","3/79","61/8104",{"v":0.0214086374431119,"d":"0.021"},{"v":0.235495011874231,"d":"0.235"},{"v":0.216074792769489,"d":"0.216"},"1543/3291/7366",3]
["hsa04137","Mitophagy - animal","3/79","68/8104",{"v":0.0284084173081016,"d":"0.028"},{"v":0.27578980967129,"d":"0.276"},{"v":0.253046659028541,"d":"0.253"},"2309/3725/7030",3]
["hsa04920","Adipocytokine signaling pathway","3/79","69/8104",{"v":0.0294962363284802,"d":"0.029"},{"v":0.27578980967129,"d":"0.276"},{"v":0.253046659028541,"d":"0.253"},"2181/6256/6513",3]
["hsa05031","Amphetamine addiction","3/79","69/8104",{"v":0.0294962363284802,"d":"0.029"},{"v":0.27578980967129,"d":"0.276"},{"v":0.253046659028541,"d":"0.253"},"2353/2354/3725",3]
["hsa04710","Circadian rhythm","2/79","31/8104",{"v":0.0363566413498599,"d":"0.036"},{"v":0.313349704616128,"d":"0.313"},{"v":0.287509157626956,"d":"0.288"},"1407/8553",2]
["hsa04926","Relaxin signaling pathway","4/79","129/8104",{"v":0.0368646711313091,"d":"0.037"},{"v":0.313349704616128,"d":"0.313"},{"v":0.287509157626956,"d":"0.288"},"2353/3725/59/7422",4]
["hsa04510","Focal adhesion","5/79","201/8104",{"v":0.0459975596631844,"d":"0.046"},{"v":0.372534104668,"d":"0.373"},{"v":0.341812885228731,"d":"0.342"},"2321/3676/3725/7422/8516",5]
["hsa00524","Neomycin, kanamycin and gentamicin biosynthesis","1/79","5/8104",{"v":0.0478118637007059,"d":"0.048"},{"v":0.372534104668,"d":"0.373"},{"v":0.341812885228731,"d":"0.342"},3099,1]
["hsa05235","PD-L1 expression and PD-1 checkpoint pathway in cancer","3/79","89/8104",{"v":0.0557571398545219,"d":"0.056"},{"v":0.403570777869245,"d":"0.404"},{"v":0.370290102970374,"d":"0.370"},"2353/3725/7097",3]
["hsa00440","Phosphonate and phosphinate metabolism","1/79","6/8104",{"v":0.0570997835386666,"d":"0.057"},{"v":0.403570777869245,"d":"0.404"},{"v":0.370290102970374,"d":"0.370"},5833,1]
["hsa05417","Lipid and atherosclerosis","5/79","215/8104",{"v":0.0582695775533134,"d":"0.058"},{"v":0.403570777869245,"d":"0.404"},{"v":0.370290102970374,"d":"0.370"},"1543/2353/3725/6256/7097",5]
["hsa00071","Fatty acid degradation","2/79","43/8104",{"v":0.0655431621540132,"d":"0.066"},{"v":0.437734690100016,"d":"0.438"},{"v":0.401636670342261,"d":"0.402"},"2181/33",2]
["hsa04933","AGE-RAGE signaling pathway in diabetic complications","3/79","100/8104",{"v":0.0736756769266198,"d":"0.074"},{"v":0.460848895156186,"d":"0.461"},{"v":0.422844750410686,"d":"0.423"},"1958/3725/7422",3]
["hsa05142","Chagas disease","3/79","102/8104",{"v":0.0771798250456079,"d":"0.077"},{"v":0.460848895156186,"d":"0.461"},{"v":0.422844750410686,"d":"0.423"},"2353/3725/7097",3]
["hsa04620","Toll-like receptor signaling pathway","3/79","104/8104",{"v":0.0807566216484754,"d":"0.081"},{"v":0.460848895156186,"d":"0.461"},{"v":0.422844750410686,"d":"0.423"},"2353/3725/7097",3]
["hsa04660","T cell receptor signaling pathway","3/79","104/8104",{"v":0.0807566216484754,"d":"0.081"},{"v":0.460848895156186,"d":"0.461"},{"v":0.422844750410686,"d":"0.423"},"2353/3725/8440",3]
["hsa05030","Cocaine addiction","2/79","49/8104",{"v":0.0822648228268281,"d":"0.082"},{"v":0.460848895156186,"d":"0.461"},{"v":0.422844750410686,"d":"0.423"},"2354/3725",2]
["hsa05144","Malaria","2/79","50/8104",{"v":0.0851683410923872,"d":"0.085"},{"v":0.460848895156186,"d":"0.461"},{"v":0.422844750410686,"d":"0.423"},"7097/975",2]
["hsa04659","Th17 cell differentiation","3/79","107/8104",{"v":0.0862551408046338,"d":"0.086"},{"v":0.460848895156186,"d":"0.461"},{"v":0.422844750410686,"d":"0.423"},"2353/3725/6256",3]
["hsa01212","Fatty acid metabolism","2/79","57/8104",{"v":0.106311760253696,"d":"0.106"},{"v":0.55223053242892,"d":"0.552"},{"v":0.506690553255919,"d":"0.507"},"2181/33",2]
["hsa05321","Inflammatory bowel disease","2/79","65/8104",{"v":0.131974645380488,"d":"0.132"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"3725/7097",2]
["hsa00830","Retinol metabolism","2/79","68/8104",{"v":0.141937165980343,"d":"0.142"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"1543/7366",2]
["hsa04917","Prolactin signaling pathway","2/79","70/8104",{"v":0.148666778714844,"d":"0.149"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"2309/2353",2]
["hsa05135","Yersinia infection","3/79","137/8104",{"v":0.149012371166315,"d":"0.149"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"2353/3676/3725",3]
["hsa00910","Nitrogen metabolism","1/79","17/8104",{"v":0.153545724549151,"d":"0.154"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},762,1]
["hsa05162","Measles","3/79","139/8104",{"v":0.153629217835147,"d":"0.154"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"2353/3725/7097",3]
["hsa05418","Fluid shear stress and atherosclerosis","3/79","139/8104",{"v":0.153629217835147,"d":"0.154"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"2353/3725/7422",3]
["hsa05223","Non-small cell lung cancer","2/79","72/8104",{"v":0.155460756326433,"d":"0.155"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"2309/6256",2]
["hsa00061","Fatty acid biosynthesis","1/79","18/8104",{"v":0.161814537181847,"d":"0.162"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},2181,1]
["hsa05166","Human T-cell leukemia virus 1 infection","4/79","219/8104",{"v":0.164850933288847,"d":"0.165"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"1958/2353/3725/6513",4]
["hsa05133","Pertussis","2/79","76/8104",{"v":0.169222217885309,"d":"0.169"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"2353/3725",2]
["hsa05412","Arrhythmogenic right ventricular cardiomyopathy","2/79","77/8104",{"v":0.17269529220882401,"d":"0.173"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"3676/8516",2]
["hsa00980","Metabolism of xenobiotics by cytochrome P450","2/79","78/8104",{"v":0.176180310612402,"d":"0.176"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"1543/7366",2]
["hsa04514","Cell adhesion molecules","3/79","149/8104",{"v":0.177365860449975,"d":"0.177"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"22854/3676/8516",3]
["hsa00100","Steroid biosynthesis","1/79","20/8104",{"v":0.178113631701566,"d":"0.178"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},6309,1]
["hsa01521","EGFR tyrosine kinase inhibitor resistance","2/79","79/8104",{"v":0.179676720139593,"d":"0.180"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"2309/7422",2]
["hsa04932","Non-alcoholic fatty liver disease","3/79","150/8104",{"v":0.179794817753704,"d":"0.180"},{"v":0.6343703947159,"d":"0.634"},{"v":0.582056708914673,"d":"0.582"},"2353/3725/6256",3]
["hsa05204","Chemical carcinogenesis","2/79","83/8104",{"v":0.193765536296725,"d":"0.194"},{"v":0.659394154566023,"d":"0.659"},{"v":0.605016871344001,"d":"0.605"},"1543/7366",2]
["hsa04012","ErbB signaling pathway","2/79","85/8104",{"v":0.200864592436594,"d":"0.201"},{"v":0.659394154566023,"d":"0.659"},{"v":0.605016871344001,"d":"0.605"},"3725/8440",2]
["hsa00515","Mannose type O-glycan biosynthesis","1/79","23/8104",{"v":0.201977234669192,"d":"0.202"},{"v":0.659394154566023,"d":"0.659"},{"v":0.605016871344001,"d":"0.605"},135152,1]
["hsa05210","Colorectal cancer","2/79","86/8104",{"v":0.204426029905006,"d":"0.204"},{"v":0.659394154566023,"d":"0.659"},{"v":0.605016871344001,"d":"0.605"},"2353/3725",2]
["hsa05161","Hepatitis B","3/79","162/8104",{"v":0.20961495705839,"d":"0.210"},{"v":0.659394154566023,"d":"0.659"},{"v":0.605016871344001,"d":"0.605"},"2353/3725/7097",3]
["hsa00534","Glycosaminoglycan biosynthesis - heparan sulfate / heparin","1/79","24/8104",{"v":0.209778719443494,"d":"0.210"},{"v":0.659394154566023,"d":"0.659"},{"v":0.605016871344001,"d":"0.605"},3340,1]
["hsa04512","ECM-receptor interaction","2/79","88/8104",{"v":0.211570316973056,"d":"0.212"},{"v":0.659394154566023,"d":"0.659"},{"v":0.605016871344001,"d":"0.605"},"3676/8516",2]
["hsa05410","Hypertrophic cardiomyopathy","2/79","90/8104",{"v":0.218740042333951,"d":"0.219"},{"v":0.662938819152792,"d":"0.663"},{"v":0.608269223314973,"d":"0.608"},"3676/8516",2]
["hsa04310","Wnt signaling pathway","3/79","166/8104",{"v":0.219797897259214,"d":"0.220"},{"v":0.662938819152792,"d":"0.663"},{"v":0.608269223314973,"d":"0.608"},"3725/4007/85409",3]
["hsa04658","Th1 and Th2 cell differentiation","2/79","92/8104",{"v":0.225931586871308,"d":"0.226"},{"v":0.670622329284675,"d":"0.671"},{"v":0.615319108772317,"d":"0.615"},"2353/3725",2]
["hsa04912","GnRH signaling pathway","2/79","93/8104",{"v":0.229534445309577,"d":"0.230"},{"v":0.670670957388921,"d":"0.671"},{"v":0.615363726734557,"d":"0.615"},"1958/3725",2]
["hsa04350","TGF-beta signaling pathway","2/79","94/8104",{"v":0.233141458944332,"d":"0.233"},{"v":0.670730043424464,"d":"0.671"},{"v":0.615417940209331,"d":"0.615"},"3625/4092",2]
["hsa05414","Dilated cardiomyopathy","2/79","96/8104",{"v":0.240366290909851,"d":"0.240"},{"v":0.671039569293378,"d":"0.671"},{"v":0.615701940865864,"d":"0.616"},"3676/8516",2]
["hsa04713","Circadian entrainment","2/79","97/8104",{"v":0.243983297532529,"d":"0.244"},{"v":0.671039569293378,"d":"0.671"},{"v":0.615701940865864,"d":"0.616"},"2353/51655",2]
["hsa01522","Endocrine resistance","2/79","98/8104",{"v":0.247602835728573,"d":"0.248"},{"v":0.671039569293378,"d":"0.671"},{"v":0.615701940865864,"d":"0.616"},"2353/3725",2]
["hsa05231","Choline metabolism in cancer","2/79","98/8104",{"v":0.247602835728573,"d":"0.248"},{"v":0.671039569293378,"d":"0.671"},{"v":0.615701940865864,"d":"0.616"},"2353/3725",2]
["hsa00053","Ascorbate and aldarate metabolism","1/79","30/8104",{"v":0.255030976853578,"d":"0.255"},{"v":0.681297038165986,"d":"0.681"},{"v":0.625113522212529,"d":"0.625"},7366,1]
["hsa00052","Galactose metabolism","1/79","31/8104",{"v":0.262320121370369,"d":"0.262"},{"v":0.681303648559152,"d":"0.681"},{"v":0.625119587476171,"d":"0.625"},3099,1]
["hsa01523","Antifolate resistance","1/79","31/8104",{"v":0.262320121370369,"d":"0.262"},{"v":0.681303648559152,"d":"0.681"},{"v":0.625119587476171,"d":"0.625"},9429,1]
["hsa00051","Fructose and mannose metabolism","1/79","33/8104",{"v":0.276687802661685,"d":"0.277"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},3099,1]
["hsa00040","Pentose and glucuronate interconversions","1/79","34/8104",{"v":0.283767676728062,"d":"0.284"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},7366,1]
["hsa05167","Kaposi sarcoma-associated herpesvirus infection","3/79","193/8104",{"v":0.290670724093995,"d":"0.291"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},"2353/3725/7422",3]
["hsa00500","Starch and sucrose metabolism","1/79","36/8104",{"v":0.297722787838784,"d":"0.298"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},3099,1]
["hsa04668","TNF signaling pathway","2/79","112/8104",{"v":0.298337691596342,"d":"0.298"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},"2353/3725",2]
["hsa05130","Pathogenic Escherichia coli infection","3/79","197/8104",{"v":0.301370268131353,"d":"0.301"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},"2353/3725/8440",3]
["hsa04725","Cholinergic synapse","2/79","113/8104",{"v":0.301952510568838,"d":"0.302"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},"2353/6572",2]
["hsa04960","Aldosterone-regulated sodium reabsorption","1/79","37/8104",{"v":0.304599324745172,"d":"0.305"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},3291,1]
["hsa05216","Thyroid cancer","1/79","37/8104",{"v":0.304599324745172,"d":"0.305"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},6256,1]
["hsa04722","Neurotrophin signaling pathway","2/79","119/8104",{"v":0.323571434200941,"d":"0.324"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},"2309/3725",2]
["hsa04935","Growth hormone synthesis, secretion and action","2/79","119/8104",{"v":0.323571434200941,"d":"0.324"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},"2353/2690",2]
["hsa04919","Thyroid hormone signaling pathway","2/79","121/8104",{"v":0.330744612506346,"d":"0.331"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},"6256/6513",2]
["hsa04216","Ferroptosis","1/79","41/8104",{"v":0.331446895896387,"d":"0.331"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},2181,1]
["hsa05219","Bladder cancer","1/79","41/8104",{"v":0.331446895896387,"d":"0.331"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},7422,1]
["hsa04015","Rap1 signaling pathway","3/79","210/8104",{"v":0.336259758684133,"d":"0.336"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},"136/2321/7422",3]
["hsa00380","Tryptophan metabolism","1/79","42/8104",{"v":0.337997273575189,"d":"0.338"},{"v":0.696951883499105,"d":"0.697"},{"v":0.639477382551951,"d":"0.639"},1543,1]

{"sheet":"Table S10","index":9,"n_rows":246,"n_cols":10,"rows_kept":246,"merged":[[0,0,0,9]],"flags":["formulas_cached_only"]}
["Table S10 The GO term analysis for each cluster"]
["ONTOLOGY","ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count"]
["BP","GO:0051412","response to corticosterone","5/146","20/18866",{"v":3.66e-07,"d":"3.66E-07"},0.000903665,0.000818363,"foxo3/fos/fosb/npas4/nefl",5]
["BP","GO:0048545","response to steroid hormone","13/146","346/18866",{"v":3e-06,"d":"3.00E-06"},0.003630558,0.003287849,"egln2/cry1/esrrg/foxo3/fos/fosb/npas4/hsd11b2/nefl/ddit4/rxra/tlr2/nr4a3",13]
["BP","GO:0051385","response to mineralocorticoid","5/146","32/18866",{"v":4.41e-06,"d":"4.41E-06"},0.003630558,0.003287849,"foxo3/fos/fosb/npas4/nefl",5]
["BP","GO:0001666","response to hypoxia","12/146","359/18866",{"v":2.35e-05,"d":"2.35E-05"},0.014515482,0.01314528,"egln2/cyp1a1/egr1/foxo3/hk2/hsd11b2/angptl4/ddit4/hif1an/slc2a1/tlr2/vegfa",12]
["BP","GO:0036293","response to decreased oxygen levels","12/146","371/18866",{"v":3.24e-05,"d":"3.24E-05"},0.016017117,0.014505166,"egln2/cyp1a1/egr1/foxo3/hk2/hsd11b2/angptl4/ddit4/hif1an/slc2a1/tlr2/vegfa",12]
["BP","GO:0043434","response to peptide hormone","13/146","447/18866",{"v":4.54e-05,"d":"4.54E-05"},0.018696258,0.016931408,"cry1/soga1/egr1/foxo3/ghr/hsd11b2/inhbb/jund/nefl/slc2a1/tlr2/nr4a3/syap1",13]
["BP","GO:0070482","response to oxygen levels","12/146","396/18866",{"v":6.08e-05,"d":"6.08E-05"},0.020883494,0.018912177,"egln2/cyp1a1/egr1/foxo3/hk2/hsd11b2/angptl4/ddit4/hif1an/slc2a1/tlr2/vegfa",12]
["BP","GO:0044706","multi-multicellular organism process","9/146","226/18866",{"v":6.76e-05,"d":"6.76E-05"},0.020883494,0.018912177,"slc38a3/cyp1a1/fos/fosb/hsd11b2/pcsk5/rxra/slc2a1/vegfa",9]
["BP","GO:0097201","negative regulation of transcription from RNA polymerase II promoter in response to stress","3/146","12/18866",{"v":9.49e-05,"d":"9.49E-05"},0.026045548,0.023586955,"jun/hif1an/nck2",3]
["BP","GO:0007565","female pregnancy","8/146","196/18866",0.000145938,0.033359905,0.030210866,"slc38a3/fos/fosb/hsd11b2/pcsk5/rxra/slc2a1/vegfa",8]
["BP","GO:0051384","response to glucocorticoid","7/146","147/18866",0.000148566,0.033359905,0.030210866,"foxo3/fos/fosb/npas4/hsd11b2/nefl/ddit4",7]
["BP","GO:0043618","regulation of transcription from RNA polymerase II promoter in response to stress","6/146","109/18866",0.000203922,0.038976582,0.035297352,"egln2/egr1/jun/hif1an/vegfa/nck2",6]
["BP","GO:0071383","cellular response to steroid hormone stimulus","8/146","206/18866",0.00020514,0.038976582,0.035297352,"egln2/cry1/esrrg/foxo3/npas4/ddit4/rxra/nr4a3",8]
["BP","GO:1902895","positive regulation of pri-miRNA transcription by RNA polymerase II","4/146","40/18866",0.000253304,0.041767665,0.037824968,"egr1/foxo3/fos/jun",4]
["BP","GO:0001655","urogenital system development","10/146","330/18866",0.00025365,0.041767665,0.037824968,"egr1/epha4/ephb3/smad7/pcsk5/acta2/rxra/vegfa/zbtb16/itga8",10]
["BP","GO:0043620","regulation of DNA-templated transcription in response to stress","6/146","115/18866",0.000272806,0.042114484,0.038139049,"egln2/egr1/jun/hif1an/vegfa/nck2",6]
["BP","GO:0031960","response to corticosteroid","7/146","164/18866",0.000291023,0.042283941,0.03829251,"foxo3/fos/fosb/npas4/hsd11b2/nefl/ddit4",7]
["BP","GO:0043405","regulation of MAP kinase activity","10/146","342/18866",0.000336814,0.046218349,0.041855526,"adora2b/dusp2/dusp4/dusp5/epha4/flt1/ghr/vegfa/map3k13/cd81",10]
["BP","GO:0032868","response to insulin","9/146","283/18866",0.000365021,0.047452691,0.042973351,"cry1/soga1/egr1/foxo3/hsd11b2/inhbb/slc2a1/tlr2/syap1",9]
["BP","GO:0010677","negative regulation of cellular carbohydrate metabolic process","4/146","45/18866",0.00040078,0.048959015,0.044337484,"cry1/soga1/ddit4/midn",4]
["BP","GO:0015718","monocarboxylic acid transport","7/146","174/18866",0.000416251,0.048959015,0.044337484,"slc38a3/acsl3/slco3a1/rxra/slc2a1/slc16a3/abcg2",7]
["BP","GO:0001704","formation of primary germ layer","6/146","127/18866",0.000464644,0.052166893,0.047242552,"dusp2/dusp4/dusp5/itga4/nr4a3/itga8",6]
["BP","GO:0048511","rhythmic process","9/146","305/18866",0.000626435,0.061607168,0.055791703,"kdm5b/cry1/egr1/foxo3/hlf/jun/jund/nfil3/bhlhe40",9]
["BP","GO:0035970","peptidyl-threonine dephosphorylation","3/146","22/18866",0.000627666,0.061607168,0.055791703,"dusp2/dusp4/dusp5",3]
["BP","GO:0045912","negative regulation of carbohydrate metabolic process","4/146","51/18866",0.000648497,0.061607168,0.055791703,"cry1/soga1/ddit4/midn",4]
["BP","GO:1902893","regulation of pri-miRNA transcription by RNA polymerase II","4/146","51/18866",0.000648497,0.061607168,0.055791703,"egr1/foxo3/fos/jun",4]
["BP","GO:0031103","axon regeneration","4/146","52/18866",0.00069835,0.063886084,0.057855499,"epha4/rtn4rl2/jun/nefl",4]
["BP","GO:0061614","pri-miRNA transcription by RNA polymerase II","4/146","53/18866",0.000750856,0.066236248,0.059983818,"egr1/foxo3/fos/jun",4]
["BP","GO:0031668","cellular response to extracellular stimulus","8/146","253/18866",0.000804379,0.068510912,0.062043762,"slc38a3/adora2b/foxo3/fos/inhbb/itga4/jun/slc2a1",8]
["BP","GO:0051961","negative regulation of nervous system development","9/146","319/18866",0.000861161,0.068783818,0.062290907,"epha4/foxg1/foxo3/lsm1/prtg/rtn4rl2/pmp22/sema5b/tlr2",9]
["BP","GO:0001706","endoderm formation","4/146","55/18866",0.000864137,0.068783818,0.062290907,"dusp2/dusp4/dusp5/itga4",4]
["BP","GO:1901216","positive regulation of neuron death","5/146","97/18866",0.000943324,0.068783818,0.062290907,"egr1/foxo3/fos/jun/ddit4",5]
["BP","GO:1901654","response to ketone","7/146","200/18866",0.00094962,0.068783818,0.062290907,"foxo3/fos/fosb/npas4/nefl/ddit4/tlr2",7]
["BP","GO:0001541","ovarian follicle development","4/146","57/18866",0.000988959,0.068783818,0.062290907,"foxo3/inhbb/taf4/vegfa",4]
["BP","GO:0071496","cellular response to external stimulus","9/146","326/18866",0.001002899,0.068783818,0.062290907,"slc38a3/cnn2/adora2b/foxo3/fos/inhbb/itga4/jun/slc2a1",9]
["BP","GO:0000188","inactivation of MAPK activity","3/146","26/18866",0.001035967,0.068783818,0.062290907,"dusp2/dusp4/dusp5",3]
["BP","GO:0035902","response to immobilization stress","3/146","26/18866",0.001035967,0.068783818,0.062290907,"cyp1a1/foxo3/fos",3]
["BP","GO:0043406","positive regulation of MAP kinase activity","8/146","264/18866",0.001058213,0.068783818,0.062290907,"adora2b/dusp5/epha4/flt1/ghr/vegfa/map3k13/cd81",8]
["BP","GO:0031102","neuron projection regeneration","4/146","59/18866",0.001125943,0.069816018,0.063225672,"epha4/rtn4rl2/jun/nefl",4]
["BP","GO:0043010","camera-type eye development","9/146","332/18866",0.001138961,0.069816018,0.063225672,"gje1/kdm5b/cyp1a1/flt1/hcn1/jun/rxra/phactr4/vegfa",9]
["BP","GO:0018126","protein hydroxylation","3/146","27/18866",0.001158889,0.069816018,0.063225672,"egln2/p4ha1/hif1an",3]
["BP","GO:0035335","peptidyl-tyrosine dephosphorylation","5/146","103/18866",0.001234865,0.072621841,0.065766637,"dusp2/dusp4/dusp5/ptprb/cdc14a",5]
["BP","GO:0010721","negative regulation of cell development","9/146","343/18866",0.001427092,0.081974819,0.074236732,"epha4/foxg1/foxo3/lsm1/prtg/rtn4rl2/pmp22/sema5b/vegfa",9]
["BP","GO:0071902","positive regulation of protein serine/threonine kinase activity","9/146","345/18866",0.001485291,0.083378815,0.075508196,"adora2b/dusp5/epha4/flt1/ghr/vegfa/map3k13/syap1/cd81",9]
["BP","GO:0033137","negative regulation of peptidyl-serine phosphorylation","3/146","30/18866",0.00158153,0.086425137,0.078266958,"smad7/ddit4/nck2",3]
["BP","GO:0046942","carboxylic acid transport","9/146","350/18866",0.001639184,0.086425137,0.078266958,"slc38a3/slc43a2/acsl3/slco3a1/rxra/slc1a5/slc2a1/slc16a3/abcg2",9]
["BP","GO:0001822","kidney development","8/146","283/18866",0.001644527,0.086425137,0.078266958,"egr1/epha4/smad7/pcsk5/acta2/vegfa/zbtb16/itga8",8]
["BP","GO:0015849","organic acid transport","9/146","353/18866",0.001737504,0.089409086,0.080969234,"slc38a3/slc43a2/acsl3/slco3a1/rxra/slc1a5/slc2a1/slc16a3/abcg2",9]
["BP","GO:0045665","negative regulation of neuron differentiation","7/146","225/18866",0.001868841,0.093903146,0.085039073,"epha4/foxg1/foxo3/lsm1/rtn4rl2/pmp22/sema5b",7]
["BP","GO:0019216","regulation of lipid metabolic process","10/146","431/18866",0.001956818,0.093903146,0.085039073,"cyp1a1/egr1/acsl3/flt1/acadl/angptl4/rxra/sc5d/nr4a3/cd81",10]
["BP","GO:0030099","myeloid cell differentiation","10/146","431/18866",0.001956818,0.093903146,0.085039073,"foxo3/fos/jun/klf13/tfe3/tlr2/vegfa/zbtb16/nr4a3/cd81",10]
["BP","GO:0072001","renal system development","8/146","292/18866",0.001999916,0.093903146,0.085039073,"egr1/epha4/smad7/pcsk5/acta2/vegfa/zbtb16/itga8",8]
["BP","GO:0035914","skeletal muscle cell differentiation","4/146","69/18866",0.0020149260000000002,0.093903146,0.085039073,"egr1/fos/hlf/pax5",4]
["BP","GO:0044262","cellular carbohydrate metabolic process","8/146","294/18866",0.002086553,0.095440484,0.086431293,"cry1/soga1/foxk1/hk2/ndst1/ddit4/slc2a1/midn",8]
["BP","GO:0050768","negative regulation of neurogenesis","8/146","295/18866",0.002130967,0.095699778,0.08666611,"epha4/foxg1/foxo3/lsm1/prtg/rtn4rl2/pmp22/sema5b",8]
["BP","GO:0005996","monosaccharide metabolic process","8/146","296/18866",0.002176122,0.095982514,0.086922157,"cry1/soga1/foxk1/hk2/npy1r/slc2a1/ugt2b15/midn",8]
["BP","GO:1904018","positive regulation of vasculature development","7/146","235/18866",0.002387178,0.103444367,0.093679642,"egr1/flt1/hk2/angptl4/rin2/hif1an/vegfa",7]
["BP","GO:0051145","smooth muscle cell differentiation","4/146","73/18866",0.002477164,0.105493003,0.095534895,"rbpms2/vegfa/itga8/olfm2",4]
["CC","GO:0098685","Schaffer collateral - CA1 synapse","5/148","84/19559",0.000442711,0.120860017,0.120230902,"adora2b/epha4/ntng1/apba2/nefl",5]
["CC","GO:0090575","RNA polymerase II transcription regulator complex","6/148","161/19559",0.00142791,0.194909769,0.193895201,"fos/jun/jund/smad7/rxra/taf4",6]
["CC","GO:0005667","transcription regulator complex","9/148","413/19559",0.004260754,0.387728653,0.385710401,"fos/npas4/jun/jund/smad7/rxra/taf4/zbtb16/nr4a3",9]
["CC","GO:0042734","presynaptic membrane","5/148","156/19559",0.006713745,0.435466435,0.433199692,"epha4/ntng1/erc1/pcdh17/syap1",5]
["CC","GO:0097060","synaptic membrane","8/148","387/19559",0.009363519,0.435466435,0.433199692,"epha4/ntng1/erc1/pcdh17/itga8/slc16a3/olfm2/syap1",8]
["CC","GO:0046658","anchored component of plasma membrane","3/148","60/19559",0.010605205,0.435466435,0.433199692,"ntng1/rtn4rl2/ca4",3]
["CC","GO:0016323","basolateral plasma membrane","6/148","246/19559",0.011165806,0.435466435,0.433199692,"slc38a3/slc1a5/slc2a1/nkd2/slc16a3/cd81",6]
["CC","GO:0005911","cell-cell junction","9/148","493/19559",0.012841135,0.438203725,0.435922734,"gje1/cnn2/epha4/rnd1/smad7/pmp22/scn4b/slc2a1/vegfa",9]
["CC","GO:0008305","integrin complex","2/148","31/19559",0.022911103,0.516151488,0.513464753,"itga4/itga8",2]
["CC","GO:0098889","intrinsic component of presynaptic membrane","3/148","83/19559",0.025124226,0.516151488,0.513464753,"epha4/ntng1/pcdh17",3]
["CC","GO:0098802","plasma membrane signaling receptor complex","6/148","307/19559",0.029517459,0.516151488,0.513464753,"gpr156/itga4/tlr2/itga8/olfm2/cd79b",6]
["CC","GO:0098636","protein complex involved in cell adhesion","2/148","36/19559",0.030290099,0.516151488,0.513464753,"itga4/itga8",2]
["CC","GO:0043204","perikaryon","4/148","156/19559",0.030907136,0.516151488,0.513464753,"epha4/rtn4rl2/itga8/syap1",4]
["CC","GO:0005912","adherens junction","4/148","166/19559",0.037522855,0.516151488,0.513464753,"epha4/rnd1/smad7/vegfa",4]
["CC","GO:0099240","intrinsic component of synaptic membrane","4/148","166/19559",0.037522855,0.516151488,0.513464753,"epha4/ntng1/pcdh17/slc16a3",4]
["CC","GO:0030426","growth cone","4/148","184/19559",0.05133019,0.516151488,0.513464753,"epha4/itga4/nefl/syap1",4]
["CC","GO:0009925","basal plasma membrane","2/148","51/19559",0.056986406,0.516151488,0.513464753,"slc1a5/cd81",2]
["CC","GO:0014704","intercalated disc","2/148","51/19559",0.056986406,0.516151488,0.513464753,"scn4b/slc2a1",2]
["CC","GO:0030427","site of polarized growth","4/148","191/19559",0.057357094,0.516151488,0.513464753,"epha4/itga4/nefl/syap1",4]
["CC","GO:0005741","mitochondrial outer membrane","4/148","192/19559",0.058247865,0.516151488,0.513464753,"epha4/acsl3/foxo3/hk2",4]
["CC","GO:0099055","integral component of postsynaptic membrane","3/148","117/19559",0.059233516,0.516151488,0.513464753,"epha4/pcdh17/slc16a3",3]
["CC","GO:0098936","intrinsic component of postsynaptic membrane","3/148","122/19559",0.065456743,0.516151488,0.513464753,"epha4/pcdh17/slc16a3",3]
["CC","GO:0031526","brush border membrane","2/148","58/19559",0.071424067,0.516151488,0.513464753,"ca4/abcg2",2]
["CC","GO:0097197","tetraspanin-enriched microdomain","1/148","10/19559",0.073159489,0.516151488,0.513464753,"cd81",1]
["CC","GO:0098981","cholinergic synapse","1/148","10/19559",0.073159489,0.516151488,0.513464753,"nefl",1]
["CC","GO:1990124","messenger ribonucleoprotein complex","1/148","10/19559",0.073159489,0.516151488,0.513464753,"lsm1",1]
["CC","GO:0001650","fibrillar center","3/148","129/19559",0.074650843,0.516151488,0.513464753,"chchd1/smad7/pax5",3]
["CC","GO:0030173","integral component of Golgi membrane","2/148","61/19559",0.077937724,0.516151488,0.513464753,"pcsk5/tpst1",2]
["CC","GO:0030122","AP-2 adaptor complex","1/148","11/19559",0.080176338,0.516151488,0.513464753,"slc18a3",1]
["CC","GO:0031968","organelle outer membrane","4/148","218/19559",0.083961318,0.516151488,0.513464753,"epha4/acsl3/foxo3/hk2",4]
["CC","GO:0150034","distal axon","5/148","309/19559",0.085917985,0.516151488,0.513464753,"epha4/itga4/nefl/slc18a3/syap1",5]
["CC","GO:0019867","outer membrane","4/148","220/19559",0.086137628,0.516151488,0.513464753,"epha4/acsl3/foxo3/hk2",4]
["CC","GO:0016328","lateral plasma membrane","2/148","65/19559",0.086898497,0.516151488,0.513464753,"nkd2/slc16a3",2]
["CC","GO:0030128","clathrin coat of endocytic vesicle","1/148","12/19559",0.087140422,0.516151488,0.513464753,"slc18a3",1]
["CC","GO:0043256","laminin complex","1/148","12/19559",0.087140422,0.516151488,0.513464753,"ntng1",1]
["CC","GO:0060198","clathrin-sculpted vesicle","1/148","12/19559",0.087140422,0.516151488,0.513464753,"slc18a3",1]
["CC","GO:0099144","anchored component of synaptic membrane","1/148","12/19559",0.087140422,0.516151488,0.513464753,"ntng1",1]
["CC","GO:0031228","intrinsic component of Golgi membrane","2/148","66/19559",0.089185185,0.516151488,0.513464753,"pcsk5/tpst1",2]
["CC","GO:0030130","clathrin coat of trans-Golgi network vesicle","1/148","13/19559",0.094052133,0.516151488,0.513464753,"slc18a3",1]
["CC","GO:0099243","extrinsic component of synaptic membrane","1/148","13/19559",0.094052133,0.516151488,0.513464753,"olfm2",1]
["CC","GO:0045178","basal part of cell","2/148","69/19559",0.096150409,0.516151488,0.513464753,"slc1a5/cd81",2]
["CC","GO:0009897","external side of plasma membrane","6/148","417/19559",0.097387327,0.516151488,0.513464753,"ghr/rtn4rl2/ackr4/ca4/abcg2/cd79b",6]
["CC","GO:0016529","sarcoplasmic reticulum","2/148","71/19559",0.100877627,0.516151488,0.513464753,"hk2/rasd1",2]
["CC","GO:0031314","extrinsic component of mitochondrial inner membrane","1/148","14/19559",0.100911863,0.516151488,0.513464753,"coq8a",1]
["CC","GO:0033276","transcription factor TFTC complex","1/148","14/19559",0.100911863,0.516151488,0.513464753,"taf4",1]
["CC","GO:0043218","compact myelin","1/148","14/19559",0.100911863,0.516151488,0.513464753,"pmp22",1]
["CC","GO:0012510","trans-Golgi network transport vesicle membrane","1/148","15/19559",0.10772,0.516151488,0.513464753,"slc18a3",1]
["CC","GO:0032591","dendritic spine membrane","1/148","15/19559",0.10772,0.516151488,0.513464753,"itga8",1]
["CC","GO:0044291","cell-cell contact zone","2/148","74/19559",0.108086483,0.516151488,0.513464753,"scn4b/slc2a1",2]
["CC","GO:0099056","integral component of presynaptic membrane","2/148","74/19559",0.108086483,0.516151488,0.513464753,"epha4/pcdh17",2]
["CC","GO:0045177","apical part of cell","6/148","433/19559",0.11121902,0.516151488,0.513464753,"slc38a3/slc2a1/ca4/itga8/slc16a3/abcg2",6]
["CC","GO:0099699","integral component of synaptic membrane","3/148","154/19559",0.11169483,0.516151488,0.513464753,"epha4/pcdh17/slc16a3",3]
["CC","GO:0017053","transcription repressor complex","2/148","76/19559",0.112966791,0.516151488,0.513464753,"jun/zbtb16",2]
["CC","GO:0031594","neuromuscular junction","2/148","76/19559",0.112966791,0.516151488,0.513464753,"epha4/nefl",2]
["CC","GO:0005869","dynactin complex","1/148","16/19559",0.11447693,0.516151488,0.513464753,"acta2",1]
["CC","GO:0030132","clathrin coat of coated pit","1/148","16/19559",0.11447693,0.516151488,0.513464753,"slc18a3",1]
["CC","GO:0045120","pronucleus","1/148","16/19559",0.11447693,0.516151488,0.513464753,"slc2a1",1]
["CC","GO:0098688","parallel fiber to Purkinje cell synapse","1/148","16/19559",0.11447693,0.516151488,0.513464753,"slc16a3",1]
["CC","GO:0000118","histone deacetylase complex","2/148","77/19559",0.115428192,0.516151488,0.513464753,"mecom/kdm3b",2]
["CC","GO:0035097","histone methyltransferase complex","2/148","77/19559",0.115428192,0.516151488,0.513464753,"kdm5b/taf4",2]
["CC","GO:0098862","cluster of actin-based cell projections","3/148","159/19559",0.119816031,0.516151488,0.513464753,"ca4/cdc14a/abcg2",3]
["CC","GO:0031253","cell projection membrane","5/148","344/19559",0.120475374,0.516151488,0.513464753,"sh2d3c/ca4/itga8/cdhr1/abcg2",5]
["CC","GO:0001518","voltage-gated sodium channel complex","1/148","17/19559",0.121183036,0.516151488,0.513464753,"scn4b",1]
["CC","GO:0042622","photoreceptor outer segment membrane","1/148","17/19559",0.121183036,0.516151488,0.513464753,"cdhr1",1]
["CC","GO:0016528","sarcoplasm","2/148","80/19559",0.122893211,0.516151488,0.513464753,"hk2/rasd1",2]
["CC","GO:0031362","anchored component of external side of plasma membrane","1/148","19/19559",0.134444288,0.538022974,0.535222391,"ca4",1]
["CC","GO:0032426","stereocilium tip","1/148","19/19559",0.134444288,0.538022974,0.535222391,"cdc14a",1]
["CC","GO:0098945","intrinsic component of presynaptic active zone membrane","1/148","19/19559",0.134444288,0.538022974,0.535222391,"ntng1",1]
["CC","GO:0016324","apical plasma membrane","5/148","361/19559",0.139299861,0.538022974,0.535222391,"slc38a3/slc2a1/ca4/slc16a3/abcg2",5]
["CC","GO:0098978","glutamatergic synapse","5/148","361/19559",0.139299861,0.538022974,0.535222391,"adora2b/epha4/ntng1/pcdh17/olfm2",5]
["CC","GO:0031225","anchored component of membrane","3/148","171/19559",0.140151244,0.538022974,0.535222391,"ntng1/rtn4rl2/ca4",3]
["CC","GO:0019897","extrinsic component of plasma membrane","3/148","172/19559",0.141896169,0.538022974,0.535222391,"smad7/olfm2/syap1",3]
["CC","GO:0005922","connexin complex","1/148","21/19559",0.147506761,0.551634873,0.548763436,"gje1",1]
["CC","GO:0098839","postsynaptic density membrane","2/148","92/19559",0.153807812,0.56043035,0.55751313,"epha4/slc16a3",2]
["CC","GO:0042629","mast cell granule","1/148","22/19559",0.153964382,0.56043035,0.55751313,"nr4a3",1]
["CC","GO:0045211","postsynaptic membrane","4/148","280/19559",0.163039473,0.585654948,0.582606426,"epha4/pcdh17/slc16a3/syap1",4]
["CC","GO:0031233","intrinsic component of external side of plasma membrane","1/148","24/19559",0.166734222,0.591148605,0.588071487,"ca4",1]
["MF","GO:0008330","protein tyrosine/threonine phosphatase activity","3/145","10/18352",{"v":5.57e-05,"d":"5.57E-05"},0.016374165,0.014631032,"dusp2/dusp4/dusp5",3]
["MF","GO:0051213","dioxygenase activity","6/145","91/18352",{"v":8.42e-05,"d":"8.42E-05"},0.016374165,0.014631032,"kdm5b/egln2/p4ha1/kdm3b/rsbn1/hif1an",6]
["MF","GO:0017017","MAP kinase tyrosine/serine/threonine phosphatase activity","3/145","13/18352",0.00013038,0.016374165,0.014631032,"dusp2/dusp4/dusp5",3]
["MF","GO:0033549","MAP kinase phosphatase activity","3/145","14/18352",0.000164979,0.016374165,0.014631032,"dusp2/dusp4/dusp5",3]
["MF","GO:0061629","RNA polymerase II-specific DNA-binding transcription factor binding","9/145","267/18352",0.000276689,0.021969083,0.019630336,"cry1/fos/jun/jund/hif1an/rxra/taf4/nr4a3/bhlhe40",9]
["MF","GO:0008138","protein tyrosine/serine/threonine phosphatase activity","4/145","45/18352",0.00043312,0.028658098,0.025607262,"dusp2/dusp4/dusp5/cdc14a",4]
["MF","GO:0003707","steroid hormone receptor activity","3/145","26/18352",0.00109936,0.05659057,0.050566146,"esrrg/rxra/nr4a3",3]
["MF","GO:0004725","protein tyrosine phosphatase activity","5/145","101/18352",0.001238915,0.05659057,0.050566146,"dusp2/dusp4/dusp5/ptprb/cdc14a",5]
["MF","GO:0001227","DNA-binding transcription repressor activity, RNA polymerase II-specific","9/145","335/18352",0.001396489,0.05659057,0.050566146,"zbtb18/foxk1/foxo3/hic1/jun/nfil3/zbtb16/mafk/bhlhe40",9]
["MF","GO:0001217","DNA-binding transcription repressor activity","9/145","336/18352",0.001425455,0.05659057,0.050566146,"zbtb18/foxk1/foxo3/hic1/jun/nfil3/zbtb16/mafk/bhlhe40",9]
["MF","GO:0140297","DNA-binding transcription factor binding","9/145","347/18352",0.001777232,0.064141928,0.057313614,"cry1/fos/jun/jund/hif1an/rxra/taf4/nr4a3/bhlhe40",9]
["MF","GO:0051019","mitogen-activated protein kinase binding","3/145","33/18352",0.002215683,0.07235314,0.064650691,"dusp2/dusp4/dusp5",3]
["MF","GO:0015175","neutral amino acid transmembrane transporter activity","3/145","34/18352",0.002416149,0.07235314,0.064650691,"slc38a3/slc43a2/slc1a5",3]
["MF","GO:0008514","organic anion transmembrane transporter activity","7/145","233/18352",0.002551496,0.07235314,0.064650691,"slc38a3/slc43a2/slco3a1/slc1a5/slc2a1/slc16a3/abcg2",7]
["MF","GO:0019825","oxygen binding","3/145","36/18352",0.002849908,0.075427575,0.067397833,"egln2/cyp1a1/hif1an",3]
["MF","GO:0140299","small molecule sensor activity","2/145","11/18352",0.003254174,0.077734729,0.069459376,"egln2/hif1an",2]
["MF","GO:0032451","demethylase activity","3/145","38/18352",0.003328691,0.077734729,0.069459376,"kdm5b/cyp1a1/kdm3b",3]
["MF","GO:0031543","peptidyl-proline dioxygenase activity","2/145","12/18352",0.003884833,0.085682152,0.076560745,"egln2/p4ha1",2]
["MF","GO:0035497","cAMP response element binding","2/145","14/18352",0.005301208,0.110767342,0.098975458,"jun/nr4a3",2]
["MF","GO:0016706","2-oxoglutarate-dependent dioxygenase activity","3/145","46/18352",0.005720881,0.113559485,0.10147036,"egln2/p4ha1/hif1an",3]
["MF","GO:0001102","RNA polymerase II activating transcription factor binding","3/145","47/18352",0.006076018,0.114865678,0.102637501,"fos/jun/bhlhe40",3]
["MF","GO:0005506","iron ion binding","5/145","151/18352",0.006997963,0.118328728,0.105731887,"egln2/cyp1a1/p4ha1/hif1an/sc5d",5]
["MF","GO:0008509","anion transmembrane transporter activity","8/145","357/18352",0.007538854,0.118328728,0.105731887,"slc38a3/slc43a2/ano5/slco3a1/slc1a5/slc2a1/slc16a3/abcg2",8]
["MF","GO:0001221","transcription cofactor binding","3/145","51/18352",0.007626767,0.118328728,0.105731887,"foxo3/mafk/nr4a3",3]
["MF","GO:0005005","transmembrane-ephrin receptor activity","2/145","17/18352",0.007800823,0.118328728,0.105731887,"epha4/ephb3",2]
["MF","GO:0004879","nuclear receptor activity","3/145","52/18352",0.008047546,0.118328728,0.105731887,"esrrg/rxra/nr4a3",3]
["MF","GO:0098531","ligand-activated transcription factor activity","3/145","52/18352",0.008047546,0.118328728,0.105731887,"esrrg/rxra/nr4a3",3]
["MF","GO:0016705","oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen","5/145","162/18352",0.009330568,0.124321302,0.111086514,"egln2/cyp1a1/p4ha1/hif1an/sc5d",5]
["MF","GO:0046943","carboxylic acid transmembrane transporter activity","5/145","162/18352",0.009330568,0.124321302,0.111086514,"slc38a3/slc43a2/slc1a5/slc16a3/abcg2",5]
["MF","GO:0005342","organic acid transmembrane transporter activity","5/145","163/18352",0.009566157,0.124321302,0.111086514,"slc38a3/slc43a2/slc1a5/slc16a3/abcg2",5]
["MF","GO:0005003","ephrin receptor activity","2/145","19/18352",0.009707709,0.124321302,0.111086514,"epha4/ephb3",2]
["MF","GO:0031418","L-ascorbic acid binding","2/145","20/18352",0.010730894,0.132807599,0.118669391,"egln2/p4ha1",2]
["MF","GO:0008028","monocarboxylic acid transmembrane transporter activity","3/145","59/18352",0.011373951,0.132807599,0.118669391,"slc38a3/slc16a3/abcg2",3]
["MF","GO:0015179","L-amino acid transmembrane transporter activity","3/145","59/18352",0.011373951,0.132807599,0.118669391,"slc38a3/slc43a2/slc1a5",3]
["MF","GO:0004714","transmembrane receptor protein tyrosine kinase activity","3/145","61/18352",0.012449078,0.141208114,0.126175619,"epha4/ephb3/flt1",3]
["MF","GO:0004721","phosphoprotein phosphatase activity","5/145","179/18352",0.013910472,0.14699525,0.131346677,"dusp2/dusp4/dusp5/ptprb/cdc14a",5]
["MF","GO:0005248","voltage-gated sodium channel activity","2/145","23/18352",0.014070074,0.14699525,0.131346677,"hcn1/scn4b",2]
["MF","GO:0070412","R-SMAD binding","2/145","23/18352",0.014070074,0.14699525,0.131346677,"fos/jun",2]
["MF","GO:0048029","monosaccharide binding","3/145","69/18352",0.017316733,0.17627546,0.157509824,"egln2/hk2/p4ha1",3]
["MF","GO:0008198","ferrous iron binding","2/145","26/18352",0.017797771,0.176642876,0.157838126,"egln2/hif1an",2]
["MF","GO:0001968","fibronectin binding","2/145","27/18352",0.01912322,0.180757685,0.161514888,"itga4/vegfa",2]
["MF","GO:0042910","xenobiotic transmembrane transporter activity","2/145","27/18352",0.01912322,0.180757685,0.161514888,"slc2a1/abcg2",2]
["MF","GO:0032452","histone demethylase activity","2/145","28/18352",0.020488906,0.180757685,0.161514888,"kdm5b/kdm3b",2]
["MF","GO:0035035","histone acetyltransferase binding","2/145","28/18352",0.020488906,0.180757685,0.161514888,"egr1/nr4a3",2]
["MF","GO:0140457","protein demethylase activity","2/145","28/18352",0.020488906,0.180757685,0.161514888,"kdm5b/kdm3b",2]
["MF","GO:0090482","vitamin transmembrane transporter activity","2/145","29/18352",0.021894122,0.188955788,0.168840251,"slc2a1/abcg2",2]
["MF","GO:0001540","amyloid-beta binding","3/145","77/18352",0.023104155,0.195156376,0.174380747,"epha4/apba2/tlr2",3]
["MF","GO:0046332","SMAD binding","3/145","79/18352",0.024695601,0.201095559,0.179687667,"fos/jun/smad7",3]
["MF","GO:0019199","transmembrane receptor protein kinase activity","3/145","80/18352",0.025513009,0.201095559,0.179687667,"epha4/ephb3/flt1",3]
["MF","GO:0033613","activating transcription factor binding","3/145","80/18352",0.025513009,0.201095559,0.179687667,"fos/jun/bhlhe40",3]
["MF","GO:0015020","glucuronosyltransferase activity","2/145","32/18352",0.026339973,0.201095559,0.179687667,"b3gat2/ugt2b15",2]
["MF","GO:0071889","14-3-3 protein binding","2/145","32/18352",0.026339973,0.201095559,0.179687667,"foxk1/ddit4",2]
["MF","GO:0015171","amino acid transmembrane transporter activity","3/145","82/18352",0.027191143,0.201361131,0.179924966,"slc38a3/slc43a2/slc1a5",3]
["MF","GO:0035257","nuclear hormone receptor binding","4/145","144/18352",0.027469785,0.201361131,0.179924966,"cry1/jund/rxra/nr4a3",4]
["MF","GO:0019956","chemokine binding","2/145","33/18352",0.027896378,0.201361131,0.179924966,"itga4/ackr4",2]
["MF","GO:0033218","amide binding","7/145","381/18352",0.03185594,0.225835859,0.201794205,"epha4/ghr/apba2/acadl/pcsk5/rxra/tlr2",7]
["MF","GO:0042277","peptide binding","6/145","308/18352",0.035753901,0.249022783,0.222512735,"epha4/ghr/apba2/pcsk5/rxra/tlr2",6]
["MF","GO:0015291","secondary active transmembrane transporter activity","5/145","236/18352",0.039535945,0.27061673,0.24180787,"slc38a3/slco3a1/slc1a5/slc8b1/slc16a3",5]
["MF","GO:0016922","nuclear receptor binding","3/145","101/18352",0.045976587,0.30936788,0.276433715,"jund/rxra/nr4a3",3]
["MF","GO:0005272","sodium channel activity","2/145","44/18352",0.047258878,0.312696242,0.279407752,"hcn1/scn4b",2]
["MF","GO:0001046","core promoter sequence-specific DNA binding","2/145","46/18352",0.051183434,0.322357764,0.288040743,"fos/taf4",2]
["MF","GO:0005496","steroid binding","3/145","106/18352",0.051753965,0.322357764,0.288040743,"esrrg/hsd11b2/cd81",3]
["MF","GO:0031490","chromatin DNA binding","3/145","106/18352",0.051753965,0.322357764,0.288040743,"foxo3/kdm3b/rxra",3]
["MF","GO:0051427","hormone receptor binding","4/145","177/18352",0.051966995,0.322357764,0.288040743,"cry1/jund/rxra/nr4a3",4]
["MF","GO:0022804","active transmembrane transporter activity","6/145","344/18352",0.055693682,0.340159875,0.303947708,"slc38a3/slco3a1/slc1a5/slc8b1/slc16a3/abcg2",6]
["MF","GO:0070888","E-box binding","2/145","50/18352",0.059365801,0.348250059,0.31117664,"cry1/bhlhe40",2]
["MF","GO:0042887","amide transmembrane transporter activity","2/145","51/18352",0.061477598,0.348250059,0.31117664,"slc38a3/abcg2",2]
["MF","GO:0005088","Ras guanyl-nucleotide exchange factor activity","3/145","115/18352",0.06298892,0.348250059,0.31117664,"rasgef1b/rin2/prex2",3]
["MF","GO:0008146","sulfotransferase activity","2/145","52/18352",0.063614801,0.348250059,0.31117664,"ndst1/tpst1",2]
["MF","GO:0003714","transcription corepressor activity","4/145","194/18352",0.06805915,0.348250059,0.31117664,"yaf2/kdm5b/nab2/bhlhe40",4]
["MF","GO:0016791","phosphatase activity","5/145","277/18352",0.069021035,0.348250059,0.31117664,"dusp2/dusp4/dusp5/ptprb/cdc14a",5]
["MF","GO:0043022","ribosome binding","2/145","57/18352",0.074663673,0.348250059,0.31117664,"taco1/efl1",2]
["MF","GO:0004983","neuropeptide Y receptor activity","1/145","10/18352",0.076277691,0.348250059,0.31117664,"npy1r",1]
["MF","GO:0005432","calcium:sodium antiporter activity","1/145","10/18352",0.076277691,0.348250059,0.31117664,"slc8b1",1]
["MF","GO:0015173","aromatic amino acid transmembrane transporter activity","1/145","10/18352",0.076277691,0.348250059,0.31117664,"slc38a3",1]
["MF","GO:0016634","oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor","1/145","10/18352",0.076277691,0.348250059,0.31117664,"acadl",1]
["MF","GO:0016679","oxidoreductase activity, acting on diphenols and related substances as donors","1/145","10/18352",0.076277691,0.348250059,0.31117664,"cyp1a1",1]
["MF","GO:0046974","histone methyltransferase activity (H3-K9 specific)","1/145","10/18352",0.076277691,0.348250059,0.31117664,"mecom",1]
["MF","GO:0071723","lipopeptide binding","1/145","10/18352",0.076277691,0.348250059,0.31117664,"tlr2",1]
["MF","GO:0102391","decanoate-CoA ligase activity","1/145","10/18352",0.076277691,0.348250059,0.31117664,"acsl3",1]
["MF","GO:0003995","acyl-CoA dehydrogenase activity","1/145","11/18352",0.083580042,0.348250059,0.31117664,"acadl",1]
["MF","GO:0005221","intracellular cyclic nucleotide activated cation channel activity","1/145","11/18352",0.083580042,0.348250059,0.31117664,"hcn1",1]
["MF","GO:0005536","glucose binding","1/145","11/18352",0.083580042,0.348250059,0.31117664,"hk2",1]
["MF","GO:0015368","calcium:cation antiporter activity","1/145","11/18352",0.083580042,0.348250059,0.31117664,"slc8b1",1]
["MF","GO:0031956","medium-chain fatty acid-CoA ligase activity","1/145","11/18352",0.083580042,0.348250059,0.31117664,"acsl3",1]
["MF","GO:0043522","leucine zipper domain binding","1/145","11/18352",0.083580042,0.348250059,0.31117664,"erc1",1]
["MF","GO:0043855","cyclic nucleotide-gated ion channel activity","1/145","11/18352",0.083580042,0.348250059,0.31117664,"hcn1",1]
["MF","GO:0047676","arachidonate-CoA ligase activity","1/145","11/18352",0.083580042,0.348250059,0.31117664,"acsl3",1]
["MF","GO:1901474","azole transmembrane transporter activity","1/145","11/18352",0.083580042,0.348250059,0.31117664,"slc38a3",1]
["MF","GO:1990459","transferrin receptor binding","1/145","11/18352",0.083580042,0.348250059,0.31117664,"cd81",1]
["MF","GO:0031406","carboxylic acid binding","4/145","212/18352",0.087580492,0.348250059,0.31117664,"egln2/p4ha1/hif1an/rxra",4]
["MF","GO:0022858","alanine transmembrane transporter activity","1/145","12/18352",0.090825061,0.348250059,0.31117664,"slc38a3",1]
["MF","GO:0035325","Toll-like receptor binding","1/145","12/18352",0.090825061,0.348250059,0.31117664,"tlr2",1]
["MF","GO:0099186","structural constituent of postsynapse","1/145","12/18352",0.090825061,0.348250059,0.31117664,"nefl",1]
["MF","GO:0005085","guanyl-nucleotide exchange factor activity","4/145","215/18352",0.091072719,0.348250059,0.31117664,"sh2d3c/rasgef1b/rin2/prex2",4]
["MF","GO:0004713","protein tyrosine kinase activity","3/145","135/18352",0.091550637,0.348250059,0.31117664,"epha4/ephb3/flt1",3]
["MF","GO:0019955","cytokine binding","3/145","135/18352",0.091550637,0.348250059,0.31117664,"ghr/itga4/ackr4",3]
["MF","GO:0019838","growth factor binding","3/145","136/18352",0.093099898,0.348250059,0.31117664,"flt1/ghr/nkd2",3]
["MF","GO:0001162","RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding","1/145","13/18352",0.098013195,0.348250059,0.31117664,"rxra",1]
["MF","GO:0004467","long-chain fatty acid-CoA ligase activity","1/145","13/18352",0.098013195,0.348250059,0.31117664,"acsl3",1]
["MF","GO:0032036","myosin heavy chain binding","1/145","13/18352",0.098013195,0.348250059,0.31117664,"nkd2",1]
["MF","GO:0032454","histone demethylase activity (H3-K9 specific)","1/145","13/18352",0.098013195,0.348250059,0.31117664,"kdm3b",1]
["MF","GO:0072542","protein phosphatase activator activity","1/145","13/18352",0.098013195,0.348250059,0.31117664,"phactr4",1]
["MF","GO:0043177","organic acid binding","4/145","224/18352",0.10194225,0.348250059,0.31117664,"egln2/p4ha1/hif1an/rxra",4]
["MF","GO:0015293","symporter activity","3/145","143/18352",0.104243583,0.348250059,0.31117664,"slc38a3/slc1a5/slc16a3",3]
["MF","GO:0005172","vascular endothelial growth factor receptor binding","1/145","14/18352",0.105144886,0.348250059,0.31117664,"vegfa",1]
["MF","GO:0015562","efflux transmembrane transporter activity","1/145","14/18352",0.105144886,0.348250059,0.31117664,"abcg2",1]
["MF","GO:0070411","I-SMAD binding","1/145","14/18352",0.105144886,0.348250059,0.31117664,"smad7",1]
["MF","GO:0016782","transferase activity, transferring sulfur-containing groups","2/145","70/18352",0.105859098,0.348250059,0.31117664,"ndst1/tpst1",2]

{"sheet":"Table S11","index":10,"n_rows":156,"n_cols":2,"rows_kept":156,"merged":[[0,0,0,1]],"flags":["formulas_cached_only"]}
["Table S11 Gene symbols and their corresponding Entrez ID\n\n"]
["Entrezid","Symbol"]
[33,"acadl"]
[59,"acta2"]
[136,"adora2b"]
[321,"apba2"]
[734,"osgin2"]
[762,"ca4"]
[974,"cd79b"]
[1265,"cnn2"]
[1407,"cry1"]
[1543,"cyp1a1"]
[1844,"dusp2"]
[1846,"dusp4"]
[1847,"dusp5"]
[1958,"egr1"]
[1961,"egr4"]
[2043,"epha4"]
[2049,"ephb3"]
[2104,"esrrg"]
[2122,"mecom"]
[2181,"acsl3"]
[2290,"foxg1"]
[2309,"foxo3"]
[2321,"flt1"]
[2353,"fos"]
[2354,"fosb"]
[2355,"fosl2"]
[2690,"ghr"]
[2835,"gpr12"]
[2842,"gpr19"]
[3090,"hic1"]
[3099,"hk2"]
[3131,"hlf"]
[3291,"hsd11b2"]
[3340,"ndst1"]
[3625,"inhbb"]
[3676,"itga4"]
[3725,"jun"]
[3727,"jund"]
[4007,"prickle3"]
[4092,"smad7"]
[4665,"nab2"]
[4741,"nefm"]
[4747,"nefl"]
[4783,"nfil3"]
[4886,"npy1r"]
[5033,"p4ha1"]
[5079,"pax5"]
[5125,"pcsk5"]
[5376,"pmp22"]
[5596,"mapk4"]
[5787,"ptprb"]
[5833,"pcyt2"]
[6256,"rxra"]
[6309,"sc5d"]
[6330,"scn4b"]
[6510,"slc1a5"]
[6513,"slc2a1"]
[6572,"slc18a3"]
[6874,"taf4"]
[7030,"tfe3"]
[7097,"tlr2"]
[7366,"ugt2b15"]
[7422,"vegfa"]
[7596,"znf45"]
[7704,"zbtb16"]
[7975,"mafk"]
[8013,"nr4a3"]
[8440,"nck2"]
[8460,"tpst1"]
[8516,"itga8"]
[8553,"bhlhe40"]
[8556,"cdc14a"]
[9123,"slc16a3"]
[9175,"map3k13"]
[9429,"abcg2"]
[10044,"sh2d3c"]
[10138,"yaf2"]
[10472,"zbtb18"]
[10765,"kdm5b"]
[10991,"slc38a3"]
[22854,"ntng1"]
[23036,"znf292"]
[23085,"erc1"]
[23219,"fbxo28"]
[23366,"kiaa0895"]
[23788,"mtch2"]
[25822,"dnajb5"]
[27253,"pcdh17"]
[27257,"lsm1"]
[27289,"rnd1"]
[28232,"slco3a1"]
[51012,"prelid3b"]
[51129,"angptl4"]
[51162,"egfl7"]
[51204,"taco1"]
[51554,"ackr4"]
[51621,"klf13"]
[51655,"rasd1"]
[51780,"kdm3b"]
[54437,"sema5b"]
[54453,"rin2"]
[54541,"ddit4"]
[54665,"rsbn1"]
[55662,"hif1an"]
[55890,"gprc5c"]
[56997,"coq8a"]
[63898,"sh2d4a"]
[64067,"npas3"]
[64407,"rgs18"]
[64420,"susd1"]
[64761,"parp12"]
[64838,"fndc4"]
[65979,"phactr4"]
[79144,"ppdpf"]
[79258,"mmel1"]
[79631,"efl1"]
[79815,"nipal2"]
[80024,"slc8b1"]
[80243,"prex2"]
[81928,"cables2"]
[84525,"hopx"]
[85409,"nkd2"]
[90007,"midn"]
[91937,"timd4"]
[92211,"cdhr1"]
[93145,"olfm2"]
[94056,"syap1"]
[112398,"egln2"]
[118487,"chchd1"]
[124935,"slc43a2"]
[126567,"c2cd4c"]
[135152,"b3gat2"]
[140710,"soga1"]
[148014,"ttc9b"]
[153020,"rasgef1b"]
[164832,"lonrf2"]
[165829,"gpr156"]
[170591,"s100z"]
[196403,"dtx3"]
[200008,"cdcp2"]
[203859,"ano5"]
[221937,"foxk1"]
[222484,"lnx2"]
[256714,"map7d2"]
[266743,"npas4"]
[283659,"prtg"]
[348093,"rbpms2"]
[348980,"hcn1"]
[349667,"rtn4rl2"]
[375616,"kcp"]
[399664,"mex3d"]
[400499,"loc400499"]
[474384,"f8a3"]
[100126572,"gje1"]

{"sheet":"Table S13","index":11,"n_rows":169,"n_cols":21,"rows_kept":169,"merged":[[0,0,0,20]],"flags":["formulas_cached_only"]}
["Table S13 Normalized expression data of DEGs."]
["gene_id","n_1","n_10","n_11","n_12","n_13","n_2","n_20","n_21","n_22","n_23","n_24","n_25","n_26","n_27","n_29","n_3","n_30","n_4","n_5","n_9"]
["LOC101061097",9.9620580996356,9.86862426511601,9.81400744355515,9.75471181425911,9.82336595668541,9.8469977152699,9.73553439262739,9.79772056062511,9.71021724382553,9.69010899428132,9.63711398464867,9.77427412993923,9.74232514795386,9.81538420338978,9.57744150211914,9.80822875297948,9.77281954520521,10.0059351867647,10.006805573061,9.85816559587774]
["LOC101061156",8.55350636437642,8.59543483235645,8.64558592942382,8.55800934823029,8.62369030597614,8.61451220550865,8.48678565813154,8.61786821771816,8.50036932735272,8.63556336097389,8.56650057952909,8.46237208199805,8.50734506299966,8.47207675247983,8.4280795094301,8.67832033165503,8.41932208692956,8.8019996454259,8.599161448315,8.67510417693522]
["LOC101061262",10.4643732715601,10.1705766592301,10.5109186122773,10.518503489294,10.2312172841554,10.4043563979858,10.3499688444252,10.0569067551884,10.3045483640674,9.97030003148728,10.2987034508863,9.78839847282534,10.1330266777249,9.97457160649203,9.70331884108252,10.5859104549364,9.8190715559237,10.6073223074593,10.3243158623314,10.6106987939631]
["LOC101061562",9.00922600803055,9.20768323474243,8.9546760701994,9.00319120828197,9.03938625465957,9.18035380120974,9.1253604955682,9.03913923996308,9.14613683057804,9.07227062175385,8.9529987062408,8.93012577228563,9.00508095580079,8.84554952721171,8.9476462321687,9.23291783261365,8.90567301041859,9.44027294024981,9.19657382219628,9.08606503126596]
["LOC101061569",9.98156168298607,9.69947429140399,9.82762393562533,9.80215310814828,9.52661711090921,9.97081535191594,9.86708173159803,9.88505317149889,9.81418059640066,9.62383807984662,9.88864499374376,9.6152366256009,9.7162953929723,9.75858226541242,9.4773690433354,9.98971157302065,9.42996385061149,10.2713729340267,10.0170397166602,9.80565681920851]
["LOC101061866",11.0324722716804,11.3101259272443,11.1106937442533,11.2987768776384,11.0090729217804,10.8443147091127,10.9414215553986,11.5112081648482,11.0381117517439,11.4779550433028,11.5180725046255,11.3058796444812,11.1634472730894,11.5043255118693,11.4320363378334,11.0372072017958,11.5777105465092,10.839397726032,10.9958282805577,11.3853058639371]
["LOC101061919",8.30780573532817,8.54927050013039,8.48095292116346,8.33211449833785,8.45557748105651,8.46256533598519,8.77310065217993,8.96994533803146,8.5722511638761,8.30845925790005,8.80021900669127,8.7455641017382,8.93380018020959,8.49923425112279,8.65807951732749,8.39896864175186,8.78808190956513,8.41708890514297,8.31536230972987,8.45230631957329]
["LOC101062387",8.30780573532817,8.14237555550174,8.27776634345946,8.33211449833785,8.24413588809588,8.02468672333361,8.34939362970639,8.40514211280355,8.42786697462303,8.47755210975737,8.36015687628561,8.401630929558,8.34360381991186,8.32410640743061,8.44118821120154,8.1501448445561,8.33570937877714,8.18650746146605,8.18319268919856,8.29858747948288]
["LOC101062434",8.1913125601628,8.24441047521492,8.19647189673562,8.21840558855898,8.01317621205554,8.21098717749635,8.13917398153257,8.11539461015307,8.16474261430821,8.02597698664093,8.05839804452429,7.96878623026996,8.03606936317952,8.04080037659735,7.91994226828174,8.25077756566372,8.05320151420767,8.57664988307432,8.36672331417326,8.31457649144285]
["LOC101062943",9.23088697590313,9.13109831180333,9.25520024906694,9.08905704165161,9.00570697785603,9.27434707865752,8.99073997531981,9.0465931305991,8.94188146243435,9.05448856657368,8.82588042205583,8.90658658583399,9.04963257860989,8.90681495340043,8.73008218459511,9.16962373184527,9.07429059912495,9.13977127549798,9.17216437698137,9.09919875554299]
["LOC101063282",9.79838503435917,9.70567011615362,9.69350322482448,9.82199182860997,9.86962510868783,9.73384877806816,9.68148611155035,10.0707409032609,9.96486823292689,9.97589696895659,10.0107314453834,10.4140631846593,10.4958394300929,10.1871010501215,10.3222196925327,9.95844170077658,9.73102262094836,10.1685026823758,9.78781285081167,9.87134932034435]
["LOC101063319",11.338339512263,11.1759646912749,11.2329781311195,11.3114029667843,11.1984748165896,11.0326648134939,11.4803105578483,11.3785982624894,11.3940932452396,11.2300335822216,11.3881688987441,11.3038246158691,11.3662967551381,11.3071425188036,11.1798538391151,10.9971634210908,11.3137266455883,11.1809940190236,11.0473249157,11.1723726264964]
["LOC101063749",11.314798169474,11.2124229944309,11.2026425595157,10.9754974542482,11.1741226854134,11.443608524732,11.178804796698,10.9316264741244,11.0996797507579,11.0766473427573,10.9477328511449,11.1710389351975,11.0747741039595,11.0814540931412,10.8825094524709,11.3743355247915,11.0791292660721,11.4710422197517,11.3563454877074,11.2375362677614]
["LOC101063882",8.98590719238658,8.88590835826166,9.16277060879954,9.04538632918334,8.9302612390118,9.09579107894483,9.09696609276806,9.0465931305991,8.93296119888009,8.79333111901901,8.99466079344482,8.81178953618024,8.95139177475754,8.83766416204404,8.64740516106481,9.16442176941302,8.6173646028022,9.55982910871336,9.11903739175738,9.25396120344032]
["LOC101063916",7.5844927763061,7.77794441351207,7.74689750126023,7.76520609400128,7.63406031342992,7.66726140897362,7.77464908451459,7.51007326352176,7.8364271275014,7.84572628446988,8.009624938368,7.96878623026996,7.81211769302054,7.95630058799495,7.8568155370455,7.65134472373354,8.09249057976673,7.81335826789802,7.58254018097546,7.65402755168964]
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["ptprb",11.6018066162448,11.6958608211662,11.6631865884824,11.7709700291058,11.6921866154279,11.4854949939907,11.7771616072662,11.8304856110653,11.765780125593,12.0153392892902,12.0203918874443,11.8999411024573,11.8133978811895,11.8580239607294,11.8060460802578,11.6649107768182,11.7718906026579,11.5903081961249,11.6269274327412,11.8361494426608]
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["rtn4rl2",9.29924712849025,9.27780685236182,9.20673701513104,9.34943816042328,9.11086255173844,8.85096168406869,8.95612250563005,9.13964703414467,9.2613529171629,9.15344955365181,9.00094624286458,8.70861993942252,8.76258457483412,8.87657603822676,8.76444131463394,9.24276068409446,8.46290889257084,9.24701108523159,9.18035296289467,9.20683627070802]
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["sema5b",10.2488129107794,10.383114685516,10.4152150575521,10.4511556989359,10.5079370921259,10.3282608292492,10.4075515193293,10.7006159742853,10.4683416931087,10.6676696728518,10.7093054779209,10.5737118714332,10.5523477234489,10.5122644108021,10.5734551149637,10.3130917561485,10.5957928120936,10.283716708877,10.1516066326713,10.5220102656606]
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["slc8b1",8.73838768939704,8.74327736855857,8.7931573564249,8.79636641290541,8.81885525936714,8.68791453778862,9.08384397540477,8.87538908390376,8.89043756071873,8.81809263950012,8.95625452586445,8.90658658583399,8.95388415734141,8.90307659000919,8.89688374335672,8.68222112273279,9.12814821565189,8.73977913290596,8.84877357225823,8.87330200551482]
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