{"text_format":"3","workbook":"xlsx","n_sheets":8,"sheets":["DAVID-GO-CC","DAVID-GO-MF","DAVID-GO-BP","DAVID-KEGG","TCGA-HSF1-COX model","TCGA-HSF1-Clinical feature","KRAS based-HSF1 expression","Sheet1"],"not_rendered":{"images":7,"defined_names":4},"read":"whole","date_system":"1900"}

{"sheet":"DAVID-GO-CC","index":0,"n_rows":196,"n_cols":10,"rows_kept":196}
["Term","Count",1,2,3,"PValue",4,5,"6","Genes"]
["Plasma membrane",78,3479,13.7809187279152,0.761815854527723,0.997767248968863,1,1,1,"SHARPIN; SLC52A2; SCRIB; ADRM1; DVL1; PLEC; PKP3; SLC39A4; RHOD; ATP6V0C; EPN1; ARFRP1; HPCAL1; CD151; BCAR1; SMPD4; TMEM8A; AXIN1; SLC16A3; CLTB; TIMM17B; HRAS; RIN1; HSPB1; NCLN; STXBP2; JUP; SLC19A1; LTBR; ZNRF1; RTN4R; ST14; ARPC1B; CAPN1; SYTL1; RAB11B; AP2A1; FGFRL1; LSR; POR; ZMYND19; TRAF2; PRSS8; RRAS; TRIP6; GNA15; ITGB4; GJB3; KCNN4; CIB1; BSG; EMD; TRIP10; SPINT2; PTOV1; STX4; BAIAP2; PKN1; AGRN; SLC4A2; GPC1; ARF5; MBOAT7; SLC9A3R2; CYBA; SIGIRR; CAPNS1; EFNA4; LY6E; NME2; RHOC; AP2S1; PAQR4; TACSTD2; S100A11; CFL1; TMEM160; PIEZO1; "]
["Nucleus",255,5847,45.0530035335689,1.4817631174705,6.97215000101367e-14,5.46616560079472e-11,2.73308280039736e-11,1.45229341204978e-10,"HSF1; ZC3H3; ADRM1; MAF1; RECQL4; SLC2A4RG; LSM4; FAM83H; ZFPL1; FBXL6; EXOSC4; PUF60; MRGBP; RALY; SNRPA; PLEC; RAD23A; PKP3; SCAF1; ZNF707; CPSF1; H2AFX; CDT1; PRICKLE3; ALDOA; ZNF598; CORO1B; GNB2; NELFB; RANGAP1; SART1; NUTF2; NDUFS8; POLR2H; RPS6KA4; ZGPAT; HMGA1; NR2F6; EPN1; OGFR; RUVBL2; EIF6; SLC35C2; ZNF787; MPG; MED15; GLI4; PPP4C; PGLS; ZNF579; PPP1CA; ZNF205; EEF1D; UCKL1; MRPL52; PPP1R13L; UBE2C; POLD1; CCDC85B; NELFA; GTF2IRD1; INO80B; COMMD5; SAC3D1; TRIM28; DAZAP1; NOC2L; BOP1; TNIP2; TRIM11; GMEB2; NT5C; RNPS1; ZNF524; BCAR1; REEP4; RABL6; PAK4; ZNF593; ZNF408; CHTF18; CDC34; KATNB1; KIF22; HES4; NDOR1; SH3GLB2; NTHL1; BCAP31; NACC1; EIF3B; KIFC2; AURKAIP1; HMG20B; XAB2; TNK2; INF2; ARPC1A; AXIN1; BTBD2; EXOSC5; MED25; RRP9; TBRG4; IRAK1; PITX1; PRPF31; RELA; NHP2; POLD4; GFER; MDK; POP7; IFRD2; MAP2K2; LMNB2; RASSF7; PTBP1; HSPB1; NCLN; JUP; SF3A2; H1FX; EXOSC7; NOSIP; PNKP; PTGES2; TALDO1; NAA10; RRP1; FZR1; STUB1; DRAP1; GADD45GIP1; NOL3; BCL2L12; MAD1L1; MVP; ZNHIT2; HIST2H2AA3; CAPN1; MAZ; LRRC45; INTS1; SSNA1; RAB11B; ZNF628; POLR2I; GTPBP3; TELO2; FGFRL1; TUBA4A; HIST3H2A; MAFK; LSR; ABHD11; MKNK2; XRCC3; SIRT6; PSMA7; RFXANK; PRMT1; ISOC2; BCL7C; CLIC3; PRSS8; TUFM; TRIP6; NR1H2; RPP21; NAP1L4; GYS1; ITGB4; GSTP1; GPX1; E2F1; CIB1; BSG; EMD; MVB12A; VDAC2; PLK1; ZMIZ2; FKBP8; MYBL2; ZNF581; SIRT7; PSMC3; PTK6; CSTB; PPIA; RNASEH2A; NUDC; ESRRA; BIK; ACD; MOB2; ZNF282; TRIP10; DDX49; GAPDH; PEX14; MIB2; ZNF768; LBX2; SMARCA4; DNTTIP1; PTOV1; SSH3; RPS6KB2; TMC6; BAIAP2; BRAT1; COX5B; SCAND1; PLCB3; FASTK; RBCK1; COX8A; RNF7; NFKBIB; TWF2; PKN1; TRAP1; BUD31; MECR; EFHD2; POLD2; ANXA11; TMSB10; SLC4A2; AATF; TAF10; ATXN2L; IRF3; SLC9A3R2; GTF3C5; SPC24; SNAPC2; CAPNS1; TRAF4; RPN1; WDR74; KLF16; EMC8; ENDOG; NME2; WDR62; CDCA5; S100A11; BANF1; GPX4; TPD52L2; CFL1; PIEZO1; "]
["Integral to membrane",29,1702,5.12367491166078,0.579083282225911,0.999746516557114,1,1,1,"MFSD10; TMUB1; LRFN4; GRINA; ZDHHC12; CYHR1; ATP6V0C; SLC35C2; TPRA1; FAM189B; MFSD3; TMEM44; TIMM17B; UNC93B1; MANBAL; TOMM34; TMEM259; ITGB4; AGTRAP; KDELR1; SPINT2; KRTCAP2; CLPTM1L; MBOAT7; DRD4; MLST8; MTX1; SERINC2; PIEZO1; "]
["Integral to plasma membrane",15,934,2.65017667844523,0.545989853658788,0.99732621776066,1,1,1,"SLC52A2; ADRM1; RCE1; CD151; TMEM8A; BCAP31; SLC16A3; SLC19A1; EBP; ST14; GPC1; DRD4; EFNA4; LY6E; TACSTD2; "]
["Golgi aparatus",26,897,4.59363957597173,0.985141180034788,0.561300167059028,1,1,1,"ZFPL1; PKMYT1; ATP6V0C; MED15; RAB1B; SCYL1; SMPD4; PAK4; BCAP31; ARFGAP1; CLTB; HRAS; ZNRF1; RAB11B; FGFRL1; LSR; YIF1A; STX10; YIPF2; KDELR1; STK25; ERGIC3; LMAN2; SLC4A2; ARF5; PITPNM1; "]
["Cytoplasm",230,5684,40.6360424028269,1.37482458771686,7.68813686598606E-9,6.02749930293307E-6,2.00916643431102e-06,1.06762194538607E-5,"HSF1; SHARPIN; SCRIB; TONSL; ADRM1; MAF1; SLC2A4RG; DVL1; LSM4; VPS28; FBXL6; EXOSC4; PPP1R14B; RALY; PLEC; CHMP4B; MIF; SCAF1; HGS; GIPC1; GUK1; CDT1; ALDOA; CORO1B; GNB2; NELFB; RANGAP1; APRT; SART1; NUTF2; POLR2H; ZGPAT; HMGA1; EPN1; OGFR; RUVBL2; GPAA1; EIF6; MPG; MED15; PPP4C; PGLS; PPP1CA; EEF1D; HPCAL1; UCKL1; PPP1R13L; OPLAH; GTF2IRD1; INO80B; COMMD5; PDAP1; OTUB1; BAD; DAZAP1; PHLDA2; NOC2L; FPGS; CDK16; TNIP2; TRIM11; ACOT8; GMEB2; NT5C; SCYL1; MVD; BCAR1; REEP4; PAFAH1B3; PAK4; UBE2M; CDC34; KATNB1; NDOR1; NAPRT; AUP1; SH3GLB2; NTHL1; EIF3B; DTX2; COMT; KIFC2; TUBGCP2; TNK2; INF2; ARPC1A; AXIN1; EXOSC5; MED25; RRP9; IRAK1; PITX1; DPP9; RELA; CDC37; GFER; DGUOK; SPNS1; MDK; ARFGAP1; CLTB; HRAS; MAP2K2; LMNB2; PTBP1; HSPB1; STXBP2; JUP; NOSIP; PTGES2; STRN4; TSTA3; TALDO1; EBP; NAA10; FZR1; STUB1; PNPLA2; NOL3; ARHGDIA; MVP; BBC3; TOMM34; ARPC1B; CAPN1; MAZ; TK1; DTYMK; RAB11B; TELO2; FGFRL1; TUBA4A; LSR; MKNK2; XRCC3; DBNDD2; ZMYND19; SIVA1; PSMA7; RFXANK; PRMT1; MAP3K11; ISOC2; BCL7C; CLIC3; TRAF2; TRIP6; NR1H2; NAP1L4; GYS1; GSTP1; GPX1; E2F1; CIB1; YIF1A; BSG; COPS7B; EMD; CTU2; VDAC2; PLK1; ZMIZ2; FKBP8; PSMC3; PTK6; CSTB; TNFRSF6B; PPIA; NUDC; BIK; MOB2; TRIP10; NUBP2; GAPDH; MIB2; SPINT2; PTOV1; PRDX5; SSH3; RPS6KB2; UBXN1; RNH1; TAZ; BAIAP2; COX5B; SCAND1; PLCB3; RBCK1; PSMD4; KRT19; RNF7; NFKBIB; TWF2; PKN1; LMAN2; VARS; EFHD2; ANXA11; BLVRB; TMSB10; SLC4A2; ARF5; AATF; TAF10; ATXN2L; IRF3; SLC9A3R2; MLST8; TSSC4; CAPNS1; TRAF4; RPN1; CDC20; FBXL8; EMC8; ENDOG; PHKG2; NME2; RHOC; NME3; TKT; WDR62; TACSTD2; S100A11; GPX4; TPD52L2; PITPNM1; CFL1; COASY; PIEZO1; "]
["Perinuclear region of cytoplasm",5,119,0.88339222614841,1.43024249184765,0.273292748357047,1,1,1,"GNB2; INF2; XRCC3; TAF10; TPD52L2; "]
["Actin cytoskeleton",4,132,0.706713780918728,1.03203148646832,0.547041307436166,1,1,1,"ALDOA; ARPC1A; ARPC1B; MVB12A; "]
["Ribonucleoprotein complex",2,65,0.353356890459364,1.05044011192851,0.574260131512175,1,1,1,"BOP1; MRPL41; "]
["Heterogeneous nuclear ribonucleoprotein complex",2,17,0.353356890459364,4.01464501331406,0.0879201610243771,1,1,1,"RALY; PTBP1; "]
["Exosomes",102,2043,18.0212014134276,1.6963976457712,5.6194404074925e-08,4.40564127947412e-05,8.81128255894823E-6,4.68210023136113e-05,"SCRIB; VPS28; PLEC; CHMP4B; MIF; RPL8; PKP3; HGS; GIPC1; CHMP1A; ALDOA; CORO1B; GNB2; APRT; NUTF2; ATP6V0C; RUVBL2; EIF6; ARRDC1; PGLS; PPP1CA; EEF1D; HPCAL1; TSPO; OTUB1; RAB1B; NT5C; LYPLA2; EPS8L2; NAPRT; AUP1; EIF3B; COMT; ARPC1A; SLC25A1; CDC37; HRAS; PTBP1; HSPB1; STXBP2; JUP; TSTA3; TALDO1; RPL28; BCL2L12; ARHGDIA; MVP; HIST2H2AA3; ARPC1B; CAPN1; RAB11B; AP2A1; TUBA4A; HIST3H2A; LSR; ARPC5L; PSMA7; CLIC3; PRSS8; TUFM; RRAS; NAP1L4; ITGB4; GSTP1; CIB1; BSG; MVB12A; EPS8L1; S100A16; CSTB; PPIA; TRIP10; GSS; GAPDH; PRDX5; STX4; RNH1; TMC6; BAIAP2; MDH2; COX5B; KRT19; TWF2; LMAN2; TRAP1; AGRN; ANXA11; BLVRB; GPC1; ARF5; SLC9A3R2; CAPNS1; RPN1; NME2; RHOC; TKT; TACSTD2; S100A11; GPX4; CFL1; SERINC2; COASY; "]
["Mitochondrion",97,1259,17.1378091872792,2.61783777901407,1.25114462260193e-18,9.80897384119916e-16,9.80897384119916e-16,5.21224899826342e-15,"RALY; PAM16; PLEC; RPL8; GUK1; ALDOA; MACROD1; NDUFS8; GPAA1; ROMO1; TOP1MT; PPP1CA; CYC1; EEF1D; MRPL52; TSPO; BAD; TRIM28; FPGS; RAB1B; SLC25A39; SMPD4; MRPS34; NTHL1; BCAP31; MRPL41; ACAD9; TBRG4; IRAK1; SLC25A22; MRPL12; SLC25A1; DGUOK; SPNS1; TIMM17B; HRAS; H1FX; PTGES2; MRPL28; GADD45GIP1; NOL3; BBC3; TOMM34; MRPL23; AP2A1; MRPS12; GTPBP3; BCKDK; ABHD11; POR; XRCC3; SIVA1; MRPL55; NDUFV1; TUFM; GSTP1; MRPS24; GPX1; E2F1; EMD; VDAC2; NDUFB7; FKBP8; PDF; PPIA; NDUFS6; MRPL4; GAPDH; PRDX5; NDUFB9; TAZ; MDH2; SLC25A10; COX5B; RHOT2; LONP1; FASTK; CLPTM1L; COX8A; CKS1B; LMAN2; TOMM40; TRAP1; MECR; ECI1; MRPL17; MRPL11; RPN1; EMC8; ENDOG; NME2; NME3; ATAD3B; GPX4; MTX1; CFL1; COASY; "]
["Lysosome",86,1620,15.1943462897526,1.80379283798825,5.3665345695462e-08,4.20736310252422E-5,8.81128255894823E-6,4.68210023136113e-05,"SLC52A2; VPS28; PLEC; CHMP4B; GIPC1; CHMP1A; RHOD; GNB2; APRT; ATP6V0C; EPN1; GPAA1; PGLS; CYC1; HPCAL1; TPRA1; OTUB1; RAB1B; LYPLA2; EPS8L2; TMEM8A; NAPRT; SH3GLB2; BCAP31; COMT; SLC25A1; DPP9; SLC16A3; SPNS1; HRAS; PTBP1; HSPB1; NCLN; STXBP2; JUP; UNC93B1; PTGES2; ARHGDIA; ST14; CAPN1; RAB11B; AP2A1; ABHD11; POR; PSMA7; CLIC3; PRSS8; TUFM; RRAS; VAC14; ITGB4; GSTP1; AGTRAP; KCNN4; CIB1; BSG; STX10; PSMC3; PPIA; KDELR1; GSS; GAPDH; SPINT2; PRDX5; STX4; TRAPPC5; ERGIC3; RNH1; MDH2; LONP1; PLCB3; LMAN2; EFHD2; ANXA11; BLVRB; ARF5; ECI1; CYBA; MLST8; CAPNS1; RPN1; AP2S1; TKT; S100A11; TPD52L2; CFL1; "]
["Cytosol",66,1178,11.660777385159,1.90377737620837,3.52263598244447e-07,0.000276174661023647,4.60291101706078e-05,2.44587443357252E-4,"VPS28; PLEC; RPL8; HGS; ALDOA; APRT; SART1; NUTF2; HMGA1; PPP1CA; EEF1D; DGAT1; UBE2C; CD151; BAD; FPGS; RAB1B; MVD; BCAR1; PAK4; NDOR1; NAPRT; BCAP31; EIF3B; COMT; TUBGCP2; AXIN1; IRAK1; RELA; CEP131; HRAS; MAP2K2; STXBP2; NOSIP; FZR1; NOL3; RPL28; ARHGDIA; MAD1L1; DTYMK; SSNA1; ANAPC11; AP2A1; TUBA4A; TRAF2; GYS1; GPX1; PLK1; PPIA; STK25; STX4; PLCB3; VARS; BLVRB; ATXN2L; IRF3; MLST8; RPN1; CDC20; AGPAT2; AP2S1; TKT; TACSTD2; BANF1; MTX1; CFL1; "]
["Ribosome",5,144,0.88339222614841,1.18195374595368,0.418463798041917,1,1,1,"PAM16; EIF6; EIF3B; RPL28; MRPL23; "]
["Membrane fraction",12,346,2.12014134275618,1.17926052986193,0.321982786963202,1,1,1,"ADRM1; PKMYT1; GIPC1; ARFRP1; CD151; BCAR1; SLC16A3; SLC19A1; KDELR1; SPINT1; SLC4A2; PITPNM1; "]
["Nucleolus",63,1257,11.13074204947,1.70304511473171,2.39618394823438e-05,0.0187860821541575,0.00234826026926969,0.0124780812287969,"HSF1; ZC3H3; EXOSC4; SNRPA; TBL3; PLEC; RPL8; SCAF1; H2AFX; NSUN5; POLR2H; HMGA1; RUVBL2; EIF6; MED15; PPP1CA; TRIM28; DAZAP1; NOC2L; BOP1; TRIM11; SH3GLB2; NACC1; ARPC1A; EXOSC5; RRP9; MRPL12; PITX1; NHP2; MDK; POP7; PTBP1; NCLN; JUP; H1FX; EXOSC7; NOSIP; PNKP; RRP1; NOL3; RPL28; NOC4L; HIST2H2AA3; ARPC1B; LSR; SIRT6; PSMA7; TUFM; RPP21; VDAC2; S100A16; SIRT7; CSTB; PPIA; USB1; DDX49; GAPDH; SMARCA4; MDH2; AATF; WDR74; FAM207A; BANF1; "]
["Nucleoplasm",33,449,5.83038869257951,2.497726702937,1.50192798791175E-6,0.00117751154252281,1.68215934646116E-4,0.00089385836994339,"PKMYT1; H2AFX; CDT1; NELFB; SART1; POLR2H; MPG; MED15; UBE2C; POLD1; NELFA; TRIM11; NTHL1; XAB2; RELA; POLD4; PTBP1; FZR1; ANAPC11; POLR2I; SIRT6; SIVA1; E2F1; CIB1; PLK1; ACD; RPS6KB2; CKS1B; POLD2; ANXA11; TAF10; IRF3; CDC20; "]
["Perinuclear region",5,131,0.88339222614841,1.2992379127913,0.342449181573491,1,1,1,"CD151; TNK2; HRAS; BAIAP2; MTX1; "]
["Midbody",1,19,0.176678445229682,1.80507255393827,0.433283055472618,1,1,1,"ANXA11; "]
["Centrosome",30,656,5.30035335689046,1.55421444735206,0.011774801199858,1,0.39016990051975,1,"RPL8; ALDOA; PPP4C; EEF1D; MZT2A; CCDC85B; SAC3D1; TRIM28; DAZAP1; MZT2B; SCYL1; RNPS1; KATNB1; TUBGCP2; CEP131; RPL28; MAD1L1; LRRC45; SSNA1; TUBA4A; POC1A; MAP3K11; TUFM; VAC14; PLK1; PPIA; GAPDH; CDC20; TKT; CFL1; "]
["Endoplasmic reticulum",34,1104,6.00706713780919,1.04662000281868,0.417216512363495,1,1,1,"PAM16; PKMYT1; TMEM189; ATP6V0C; GPAA1; RCE1; EEF1D; DGAT1; PRKCSH; RAB1B; BCAR1; SMPD4; BCAP31; COMT; FAM3A; SPNS1; NCLN; UNC93B1; PTGES2; EBP; RTN4R; STUB1; POR; DPM2; RRAS; CIB1; EMD; TNFRSF6B; KDELR1; BIK; TAZ; TMC6; LONP1; RPN1; "]
["Mitochondrial inner membrane presequence translocase complex",1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,1,1,"TIMM17B; "]
["Secretory granule",1,50,0.176678445229682,0.686151354736385,0.775905276682477,1,1,1,"STXBP2; "]
["Nucleosome",2,44,0.353356890459364,1.55167261250789,0.373088387777994,1,1,1,"H2AFX; H1FX; "]
["Protein phosphatase type 2A complex",1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,1,1,"STRN4; "]
["Endosome",8,303,1.41342756183746,0.898112954137175,0.671676726332514,1,1,1,"VPS28; HGS; RHOD; ATP6V0C; SPNS1; ZNRF1; PKN1; S100A11; "]
["Cell surface",3,205,0.530035335689046,0.498823443259244,0.943028779112593,1,1,1,"MIF; HSPB1; STX4; "]
["Oligosaccharyltransferase complex",1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,1,1,"RPN1; "]
["Extracellular",35,1825,6.18374558303887,0.651751843407957,0.99841171836049,1,1,1,"ADRM1; VPS28; MIF; HGS; CPSF1; CYC1; PDAP1; GSDMD; PAFAH1B3; FAM3A; GFER; MDK; JUP; INTS1; TRAF2; PRSS8; GPX1; VDAC2; STX10; FBRS; PTK6; TNFRSF6B; GAPDH; SPINT1; SPINT2; MDH2; PLCB3; NMB; AGRN; GPC1; RHBDD2; RPN1; EFNA4; TKT; CFL1; "]
["Cytoskeleton",22,427,3.886925795053,1.75120667009808,0.00823385076034357,1,0.39016990051975,1,"PLEC; CORO1B; EIF6; PPP1CA; TSPO; INF2; PLEKHN1; SLC25A1; HSPB1; JUP; RHPN1; RRP1; ARHGDIA; TUFM; GPX1; PLK1; PPIA; GAPDH; TRAP1; ARF5; MTX1; CFL1; "]
["Extracellular region",6,442,1.06007067137809,0.461952990613095,0.990736925661604,1,1,1,"MIF; MAP2K2; TUBA4A; PPIA; SPINT1; SPINT2; "]
["Integrin complex",1,22,0.176678445229682,1.55903813041193,0.481914561394994,1,1,1,"ITGB4; "]
["Internal side of plasma membrane",1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,1,1,"GNB1L; "]
["Nuclear pore",3,42,0.530035335689046,2.43427265181094,0.125689457666795,1,1,1,"RANGAP1; NUTF2; MAD1L1; "]
["Membrane",14,350,2.47349823321555,1.35991914742361,0.153296609284086,1,1,1,"CD151; BCAP31; SLC16A3; RTN4R; CIB1; KDELR1; STX4; GPC1; MBOAT7; ATXN2L; SIGIRR; DRD4; RPN1; TACSTD2; "]
["Extracellular space",2,404,0.353356890459364,0.169028270776645,0.999931960866646,1,1,1,"PRSS8; GPC1; "]
["Extracellular matrix",1,120,0.176678445229682,0.285929749607254,0.972575276901301,1,1,1,"AGRN; "]
["Endoplasmic reticulum membrane",4,150,0.706713780918728,0.908195963793635,0.647779917447145,1,1,1,"ALG3; BCAP31; DPM2; PEX16; "]
["Ubiquitin ligase complex",1,43,0.176678445229682,0.797824441998758,0.723640365293076,1,1,1,"TRAF7; "]
["Microtubule",9,129,1.59010600706714,2.37277644104497,0.0141172031879489,1,0.425687973051998,1,"RANGAP1; PPP1CA; KATNB1; KIF22; HSPB1; TUBA4A; MAP3K11; PLK1; NME2; "]
["NuA4 histone acetyltransferase complex",1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,1,1,"RUVBL2; "]
["Nuclear speck",1,31,0.176678445229682,1.10656011771579,0.604205390699891,1,1,1,"PRPF31; "]
["Kinetochore",7,90,1.23674911660777,2.64595626938118,0.016863153325842,1,0.48965600768371,1,"RANGAP1; KIF22; MAD1L1; PLK1; SMARCA4; SPC24; CDC20; "]
["Soluble fraction",8,180,1.41342756183746,1.51178937966283,0.162357327848365,1,1,1,"GIPC1; RANGAP1; COMT; CTU2; TNFRSF6B; SPINT1; SPINT2; NMB; "]
["ER-Golgi intermediate compartment",5,30,0.88339222614841,5.67188133804694,1.68084791275069E-3,1,0.109815396966378,0.583532183996457,"SCYL1; YIF1A; KDELR1; ERGIC3; LMAN2; "]
["Nuclear envelope",2,71,0.353356890459364,0.961683026002987,0.622465247849045,1,1,1,"EMD; ANXA11; "]
["Focal adhesion",1,45,0.176678445229682,0.762373455906834,0.739705032834691,1,1,1,"TRIP6; "]
["Gap junction",1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,1,1,"GJB3; "]
["Mitochondrial respiratory chain complex I",5,46,0.88339222614841,3.69948182905431,0.0110077483885973,1,0.39016990051975,1,"NDUFS8; NDUFV1; NDUFB7; NDUFS6; NDUFB9; "]
["Intracellular",6,151,1.06007067137809,1.35214781392553,0.285773064187295,1,1,1,"MAF1; RUVBL2; PRKCSH; NAA10; TELO2; VARS; "]
["Cell-cell junction",3,38,0.530035335689046,2.69044446468239,0.100416391829288,1,1,1,"SCRIB; PKP3; JUP; "]
["Trans-Golgi network",1,31,0.176678445229682,1.10656011771579,0.604205390699891,1,1,1,"SMPD4; "]
["Mitochondrial small ribosomal subunit",1,17,0.176678445229682,2.01730918579463,0.39835639063409,1,1,1,"MRPS24; "]
["Proteasome complex",5,34,0.88339222614841,5.00479738179326,0.00297986185681365,1,0.166872263981564,0.886718432383469,"ADRM1; PSMA7; PSMC3; UBXN1; PSMD4; "]
["Golgi membrane",5,55,0.88339222614841,3.09422212242845,0.0225551363562337,1,0.623665162853003,1,"PAK4; ARFGAP1; B4GALT2; BSG; STX10; "]
["Cytoplasmic membrane-bounded vesicle",1,19,0.176678445229682,1.80507255393827,0.433283055472618,1,1,1,"GIPC1; "]
["Peroxisomal membrane",2,13,0.353356890459364,5.24897092055897,0.0544331436114236,1,0.909463964418037,1,"PEX14; PEX16; "]
["Endosome membrane",2,27,0.353356890459364,2.52828995470093,0.18809944291615,1,1,1,"VAC14; IRF3; "]
["Integrator complex",1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,1,1,"INTS1; "]
["Nuclear matrix",2,37,0.353356890459364,1.84515297693791,0.297438351149051,1,1,1,"CHMP1A; EIF6; "]
["Cytoplasmic microtubule",1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,1,1,"TUBGCP2; "]
["Cytoplasmic vesicle membrane",1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,1,1,"GIPC1; "]
["Nuclear outer membrane",1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,1,1,"EMD; "]
["Protein complex",1,65,0.176678445229682,0.527833091068552,0.857036260125162,1,1,1,"CTU2; "]
["Eukaryotic translation initiation factor 3 complex",1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"EIF3B; "]
["Mitochondrial nucleoid",4,31,0.706713780918728,4.39337234855476,0.0124416422359614,1,0.39016990051975,1,"TOP1MT; TUFM; VDAC2; LONP1; "]
["Spindle",4,30,0.706713780918728,4.5397692945246,0.0110886849341346,1,0.39016990051975,1,"MZT2B; MAD1L1; ANXA11; CDC20; "]
["Transcription factor complex",2,43,0.353356890459364,1.58774963209654,0.362452480407329,1,1,1,"HMGA1; RELA; "]
["Nuclear membrane",1,78,0.176678445229682,0.439872186262871,0.90318957919737,1,1,1,"EMD; "]
["Late endosome",1,40,0.176678445229682,0.857646319679245,0.697668980318492,1,1,1,"CD151; "]
["Mitochondrial outer membrane",4,29,0.706713780918728,4.69625910129897,0.00983430666474055,1,0.39016990051975,1,"TSPO; BAD; TOMM34; VDAC2; "]
["Cell cortex",1,20,0.176678445229682,1.71486403050308,0.4499798329091,1,1,1,"GIPC1; "]
["Spindle pole",1,24,0.176678445229682,1.42917239693322,0.511998212519025,1,1,1,"KATNB1; "]
["Anaphase-promoting complex",4,18,0.706713780918728,7.56460169509624,1.63547211323334E-3,1,0.109815396966378,0.583532183996457,"UBE2S; UBE2C; FZR1; ANAPC11; "]
["Ruffle",3,24,0.530035335689046,4.25921674729603,0.0324370422040322,1,0.668928208434724,1,"BCAR1; NME2; S100A11; "]
["Microsome",4,156,0.706713780918728,0.87326758879997,0.677860804793438,1,1,1,"ADRM1; COMT; VAC14; CFL1; "]
["Lamellipodium",1,23,0.176678445229682,1.49128332248442,0.497180927410287,1,1,1,"NME2; "]
["Intracellular membrane-bounded organelle",3,127,0.530035335689046,0.805163326530019,0.726205644205501,1,1,1,"HGS; NACC1; MVP; "]
["Cell junction",2,38,0.353356890459364,1.79660909435602,0.308384015556268,1,1,1,"SCRIB; JUP; "]
["Cis-Golgi network",1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,1,1,"SCYL1; "]
["Beta-catenin destruction complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"AXIN1; "]
["Mitochondrial matrix",3,79,0.530035335689046,1.29431456907452,0.412077293309858,1,1,1,"MDH2; LONP1; ECI1; "]
["Mitochondrial alpha-ketoglutarate dehydrogenase complex",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,1,1,"BCKDK; "]
["Plasma membrane enriched fraction",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,1,1,"STX4; "]
["COPI vesicle coat",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"SCYL1; "]
["Peroxisome",5,111,0.88339222614841,1.53331374610205,0.229016646775373,1,1,1,"ACOT8; MVD; PEX14; PEX16; PRDX5; "]
["MLL1 complex",2,27,0.353356890459364,2.52828995470093,0.18809944291615,1,1,1,"RUVBL2; PRPF31; "]
["Mitochondrial ribosome",3,13,0.530035335689046,7.86039923924502,5.81899543413621E-3,1,0.304139494690853,1,"MRPL28; MRPS12; MRPL11; "]
["Voltage-gated potassium channel complex",1,42,0.176678445229682,0.816815740308655,0.71524064698807,1,1,1,"KCNN4; "]
["STAGA complex",1,12,0.176678445229682,2.85715480852345,0.301349333118106,1,1,1,"TAF10; "]
["Spliceosomal complex",2,46,0.353356890459364,1.48422324878227,0.394137515720453,1,1,1,"SNRPA; SF3A2; "]
["Lateral plasma membrane",1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,1,1,"AXIN1; "]
["Cell-cell adherens junction",2,13,0.353356890459364,5.24897092055897,0.0544331436114236,1,0.909463964418037,1,"SCRIB; JUP; "]
["Endomembrane system",1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,1,1,"CHMP1A; "]
["Basolateral plasma membrane",1,40,0.176678445229682,0.857646319679245,0.697668980318492,1,1,1,"STX4; "]
["Early endosome",3,69,0.530035335689046,1.48186920884767,0.331790152655432,1,1,1,"HGS; CHMP1A; CD151; "]
["Mitochondrial inner membrane",4,58,0.706713780918728,2.34853433078233,0.0910309808911736,1,1,1,"SLC25A22; SLC25A1; NDUFV1; SLC25A10; "]
["SNARE complex",1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,1,1,"STXBP2; "]
["Transcription factor TFIID complex",1,17,0.176678445229682,2.01730918579463,0.39835639063409,1,1,1,"TAF10; "]
["Gamma-tubulin ring complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"MZT2B; "]
["Heterotrimeric G-protein complex",1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,1,1,"GNA15; "]
["Cytoplasmic vesicle",5,160,0.88339222614841,1.06376575810755,0.509601502429045,1,1,1,"DVL1; TRAF7; RAB1B; NOSIP; ZNRF1; "]
["Nuclear inner membrane",1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,1,1,"EMD; "]
["Cytosolic large ribosomal subunit",2,36,0.353356890459364,1.89639299295952,0.286466087718083,1,1,1,"RPL8; RPL28; "]
["Transport vesicle",1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"YIPF2; "]
["Stored secretory granule",1,19,0.176678445229682,1.80507255393827,0.433283055472618,1,1,1,"CYBA; "]
["Specific granule",3,8,0.530035335689046,12.7670154934554,0.0012717003702115,0.997013090245815,0.0997013090245815,0.529788392243685,"STXBP2; STX4; ANXA11; "]
["Arp2/3 protein complex",1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,1,1,"ARPC1B; "]
["Intermediate filament",2,36,0.353356890459364,1.89639299295952,0.286466087718083,1,1,1,"KRT19; NME2; "]
["NADPH oxidase complex",1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,1,1,"CYBA; "]
["Transcription factor TFTC complex",1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,1,1,"TAF10; "]
["Endocytic vesicle membrane",2,22,0.353356890459364,3.10264023973067,0.13587584004334,1,1,1,"AP2A1; AP2S1; "]
["Chromosome",4,59,0.706713780918728,2.30873540973874,0.0955036492127038,1,1,1,"RUVBL2; EIF6; INO80B; INO80E; "]
["Condensed nuclear chromosome",1,12,0.176678445229682,2.85715480852345,0.301349333118106,1,1,1,"CHMP1A; "]
["Small nuclear ribonucleoprotein complex",3,16,0.530035335689046,6.38749494706919,0.0106713393628675,1,0.39016990051975,1,"LSM4; RRP9; SF3A2; "]
["SWI/SNF-type complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"SMARCA4; "]
["Integral to membrane of membrane fraction",1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,1,1,"TOMM40; "]
["Prefoldin complex",1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.909463964418037,1,"PFDN2; "]
["Mitochondrial large ribosomal subunit",3,8,0.530035335689046,12.7670154934554,0.0012717003702115,0.997013090245815,0.0997013090245815,0.529788392243685,"MRPL41; MRPL12; MRPL23; "]
["U4 snRNP",1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.909463964418037,1,"PRPF31; "]
["Synapse",1,33,0.176678445229682,1.03951618450065,0.627198596777642,1,1,1,"SCRIB; "]
["Exosome (RNase complex)",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"EXOSC7; "]
["Interleukin-1 receptor complex",2,3,0.353356890459364,22.6874125171004,0.00254374438366584,1,0.15340735359954,0.815169189020585,"IRAK1; TRIP6; "]
["SWI/SNF complex",1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,1,1,"SMARCA4; "]
["Apical membrane",1,16,0.176678445229682,2.14331225798667,0.380095435962882,1,1,1,"SLC9A3R2; "]
["Clathrin coat of trans-Golgi network vesicle",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"AP2A1; "]
["Integral to peroxisomal membrane",1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,1,1,"PEX16; "]
["Costamere",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"KRT19; "]
["Protein-DNA complex",1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,1,1,"JUP; "]
["Integral to mitochondrial outer membrane",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"RHOT2; "]
["Catenin complex",1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,1,1,"JUP; "]
["Peroxisomal matrix",1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,1,1,"ACOT8; "]
["DNA-directed RNA polymerase II, core complex",2,13,0.353356890459364,5.24897092055897,0.0544331436114236,1,0.909463964418037,1,"POLR2H; POLR2I; "]
["Axin-APC-beta-catenin-GSK3B complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"AXIN1; "]
["Cajal body",2,21,0.353356890459364,3.25031469188349,0.125865918672854,1,1,1,"SART1; PRPF31; "]
["Cell leading edge",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"SCRIB; "]
["Cytoplasmic dynein complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"DYNLRB1; "]
["Mitochondrial outer membrane translocase complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"TOMM40; "]
["Phagocytic vesicle",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,1,1,"ANXA11; "]
["Nuclear body",1,12,0.176678445229682,2.85715480852345,0.301349333118106,1,1,1,"NACC1; "]
["Phosphorylase kinase complex",1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.909463964418037,1,"PHKG2; "]
["PCAF complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"TAF10; "]
["U6 snRNP",1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.909463964418037,1,"LSM4; "]
["Nuclear telomere cap complex",1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,1,1,"ACD; "]
["Chromosome, telomeric region",2,17,0.353356890459364,4.01464501331406,0.0879201610243771,1,1,1,"H2AFX; ACD; "]
["I band",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"ALDOA; "]
["APC-Axin-1-beta-catenin complex",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"AXIN1; "]
["MLL5-L complex",1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,1,1,"PPP1CA; "]
["Nuclear inclusion body",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"STUB1; "]
["Basal lamina",1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,1,1,"AGRN; "]
["Nuclear telomeric heterochromatin",1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.909463964418037,1,"SIRT6; "]
["Acrosome",1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,1,1,"CEP131; "]
["AP-2 adaptor complex",2,6,0.353356890459364,11.3625809777824,0.0119906115174986,1,0.39016990051975,1,"AP2A1; AP2S1; "]
["Nucleolar riboNuclease P complex",1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,1,1,"POP7; "]
["Postsynaptic membrane",1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,1,1,"SCRIB; "]
["Clathrin coat",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"CLTB; "]
["Desmosome",2,11,0.353356890459364,6.20246245926178,0.0398909174733957,1,0.781861982478556,1,"EIF6; JUP; "]
["Small nucleolar ribonucleoprotein complex",1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,1,1,"RRP9; "]
["Presynaptic membrane",1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,1,1,"SCRIB; "]
["Microtubule organizing center",2,10,0.353356890459364,6.82208907856865,0.0332757654706049,1,0.668928208434724,1,"CHMP1A; TUBGCP2; "]
["Zymogen granule",1,34,0.176678445229682,1.00895116878467,0.638190188919918,1,1,1,"VDAC2; "]
["Transcription factor TFIIIC complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"GTF3C5; "]
["Pre-snoRNP complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"PIH1D1; "]
["Eukaryotic translation elongation factor 1 complex",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"EEF1D; "]
["Cell projection",1,41,0.176678445229682,0.836733217516864,0.706586091148255,1,1,1,"KIFC2; "]
["Cohesin complex",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"CDCA5; "]
["Outer kinetochore of condensed nuclear chromosome",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"PLK1; "]
["Azurophil granule",2,6,0.353356890459364,11.3625809777824,0.0119906115174986,1,0.39016990051975,1,"STXBP2; ANXA11; "]
["Vacuole",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,1,1,"STX4; "]
["Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"DPM2; "]
["Secretory vesicle (None)",2,6,0.353356890459364,11.3625809777824,0.0119906115174986,1,0.39016990051975,1,"SMPD4; FGFRL1; "]
["Nucleolus organizer region",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.623665162853003,1,"SIRT7; "]
["GPI-anchor transamidase complex",1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,1,1,"GPAA1; "]
["Tertiary granule",1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.909463964418037,1,"STXBP2; "]
["Catenin-TCF7L2 complex",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.623665162853003,1,"JUP; "]
["Ubiquitin conjugating enzyme complex",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"STUB1; "]
["Vesicle (None)",1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,1,1,"TNK2; "]
["PeBoW complex",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"BOP1; "]
["Basolateral membrane",1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,1,1,"SCRIB; "]
["Ndc80 complex",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,1,1,"SPC24; "]
["Extracellular vesicular exosome",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.623665162853003,1,"ALDOA; "]
["Dolichol-phosphate-mannose synthase complex",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,1,1,"DPM2; "]
["Cyclin-dependent protein kinase activating kinase holoenzyme complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"PUF60; "]
["U4atac snRNP",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.623665162853003,1,"PRPF31; "]
["U4/U6 x U5 tri-snRNP complex",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,1,1,"PRPF31; "]
["Nuclear replication fork",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,1,1,"ZMIZ2; "]
["Chromatin assembly complex",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"NAP1L4; "]
["Nuclear lamina",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,1,1,"LMNB2; "]
["Cytosolic part",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.623665162853003,1,"PRDX5; "]
["Katanin complex",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.623665162853003,1,"KATNB1; "]
["Angiogenin-PRI complex",1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.909463964418037,1,"RNH1; "]
["mRNA cleavage and polyadenylation specificity factor complex",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.623665162853003,1,"CPSF1; "]
["Gamma-catenin-TCF7L2 complex",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.623665162853003,1,"JUP; "]
["Scrib-APC-beta-catenin complex",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.623665162853003,1,"SCRIB; "]

{"sheet":"DAVID-GO-MF","index":1,"n_rows":86,"n_cols":10,"rows_kept":86}
["Term","Count",1,2,3,"PValue",4,5,"6","Genes"]
["Molecular function unknown",163,5685,28.7985865724382,0.97417823051841,0.672394467912786,1,1,1,"SHARPIN; ADRM1; MROH1; MFSD10; FAM83H; ADCK5; PPDPF; PAM16; TBL3; YDJC; TMUB1; CPTP; TMEM134; LRFN4; PPP1R16A; TSR3; RBM42; GET4; ZDHHC12; CYHR1; TIGD5; NSUN5; CORO1B; CCDC124; MACROD1; SART1; UQCC3; UBALD2; ARRDC1; ROMO1; HSPBP1; CYC1; MZT2A; CCDC85B; MFSD2B; PWWP2B; INO80B; COMMD5; SAC3D1; PHLDA2; NOC2L; BOP1; PPP1R35; MZT2B; PSMG3; PERM1; GSDMD; FAM189B; LIME1; REEP4; MXD3; SMPD4; PRR7; TMEM8A; CHCHD2; NUDT22; AUP1; SH3GLB2; NACC1; MFSD3; FAM110A; INF2; PLEKHN1; BTBD2; TMEM44; SAMD10; TRABD; TBRG4; CDK2AP2; TSNARE1; FAM3A; ZNHIT1; IFRD2; RIN1; STXBP2; YIF1B; STRN4; NMRAL1; RPUSD1; DDA1; JOSD2; RRP1; MANBAL; INO80E; NOC4L; BCL2L12; ARHGDIA; SHKBP1; MAD1L1; BBC3; ZNHIT2; LRRC45; SYTL1; UBALD1; INTS1; BOLA2; SSNA1; QPCTL; AGAP3; FAM173A; TELO2; CTU1; FAAP20; ABHD11; ABHD16B; DCAF15; MICALL2; POC1A; DBNDD2; ARPC5L; ZMYND19; TMEM223; ISOC2; BCL7C; PARP10; TMEM259; VAC14; SAMD1; AGTRAP; COPS7B; CTU2; MVB12A; EPS8L1; HGH1; SPSB3; YIPF2; KDELR1; ZNF511; MOB2; USB1; NUBP2; PTOV1; FAM98C; TRAPPC5; ORAI3; ERGIC3; UQCC2; TMC6; BRAT1; LRRC14; KRTCAP2; CLPTM1L; WDR34; DYNLRB1; MALSU1; EFHD2; ATXN2L; RHBDD2; SIGIRR; TSSC4; WDR74; EMC8; LY6E; FAM207A; PIH1D1; WDR62; CDCA5; TPD52L2; RNF181; TMEM160; SERINC2; ANKRD9; PIEZO1; "]
["Protease inhibitor activity",4,94,0.706713780918728,1.44919132569602,0.299724903616171,1,1,1,"NOL3; CSTB; SPINT1; SPINT2; "]
["Receptor signaling complex scaffold activity",19,322,3.35689045936396,2.00571011123961,3.34347703047989E-3,0.748938854827496,0.149787770965499,0.691556285848872,"DVL1; HGS; TRAF7; EPN1; BCAR1; EPS8L2; AXIN1; SPNS1; SH2D3A; RHPN1; TRAF2; FKBP8; BIK; TRIP10; BAIAP2; SLC9A3R2; MLST8; TRAF4; AP2S1; "]
["Deacetylase activity",2,14,0.353356890459364,4.87431203971964,0.0622977054200459,1,0.775260334116126,1,"SIRT6; SIRT7; "]
["Cell adhesion molecule activity",4,356,0.706713780918728,0.382681600316517,0.993666113753842,1,1,1,"PKP3; JUP; ITGB4; NDUFB7; "]
["GTPase activity",13,222,2.29681978798587,1.99094913906416,0.0146374452747833,1,0.446129147806338,1,"RHOD; GNB2; ARFRP1; RAB1B; RABL6; GNB1L; HRAS; GTPBP3; RRAS; GNA15; RHOT2; ARF5; RHOC; "]
["Transporter activity",19,576,3.35689045936396,1.1212630213369,0.337864132201763,1,1,1,"VPS28; CHMP4B; SLC39A4; NUTF2; KATNB1; BCAP31; TMEM44; SLC25A1; UNC93B1; NOSIP; TOMM34; AP2A1; YIF1A; STX10; SLC25A10; DYNLRB1; LMAN2; TOMM40; MTX1; "]
["Translation regulator activity",5,101,0.88339222614841,1.68511195876437,0.177127124230658,1,1,1,"EIF6; PPP1R13L; EIF3B; TUFM; RNH1; "]
["ATPase activity",3,111,0.530035335689046,0.921212450252929,0.638510537353368,1,1,1,"ATAD3A; ATP6V0C; ATAD3B; "]
["Protein-tyrosine kinase activity",3,38,0.530035335689046,2.69044446468239,0.100416391829288,1,1,1,"TNK2; PTK6; TWF2; "]
["Catalytic activity",15,532,2.65017667844523,0.958553379101604,0.604703955776307,1,1,1,"GUK1; NDOR1; NAPRT; ACAD9; DGUOK; TK1; DTYMK; BCKDK; POR; NDUFS6; GAPDH; MDH2; MECR; CYBA; NME3; "]
["Transferase activity",5,156,0.88339222614841,1.09104005483487,0.487279616007795,1,1,1,"APRT; ALG3; UCKL1; TRPT1; COASY; "]
["GTPase activator activity",6,144,1.06007067137809,1.41787265732167,0.250752991263856,1,1,1,"RANGAP1; TBC1D10B; ARFGAP1; RASSF7; RAB11B; ARHGAP39; "]
["Structural constituent of ribosome",13,152,2.29681978798587,2.90777329362301,0.000569183976172076,0.127497210662545,0.127497210662545,0.588642830409629,"RPL8; MRPL52; MRPS34; MRPL41; MRPL12; RPL28; MRPL23; MRPS12; MRPL55; MRPS24; MRPL4; MRPL17; MRPL11; "]
["Ion channel activity",1,66,0.176678445229682,0.519836831546229,0.861258408659174,1,1,1,"SLC25A39; "]
["Hydrolase activity",10,203,1.76678445229682,1.67522078264773,0.0780552931855154,1,0.874219283677773,1,"MPG; PGLS; OPLAH; ACOT8; NT5C; PNPLA2; NUDT8; PTRH1; PDF; HAGHL; "]
["Protein binding",11,182,1.9434628975265,2.05516869134345,0.019155020020822,1,0.446129147806338,1,"FZR1; GADD45GIP1; SIVA1; YIF1A; TNFRSF6B; NUDC; PEX14; PEX16; CKS1B; SPC24; CDC20; "]
["Serine-type peptidase activity",4,98,0.706713780918728,1.39004669450753,0.326409351897683,1,1,1,"ST14; PRSS8; PRSS22; LONP1; "]
["Receptor binding",1,129,0.176678445229682,0.265982708707593,0.979078064651447,1,1,1,"EFNA4; "]
["Structural molecule activity",4,269,0.706713780918728,0.506443911113651,0.958379490447262,1,1,1,"CLTB; LMNB2; MRPL28; EMD; "]
["Structural constituent of cytoskeleton",4,137,0.706713780918728,0.994368852847845,0.576520693946417,1,1,1,"ARPC1A; CEP131; TUBA4A; KRT19; "]
["Cytoskeletal protein binding",7,218,1.23674911660777,1.09243852945736,0.461611607183491,1,1,1,"PAK4; TUBGCP2; INF2; ARPC1B; MIB2; TMSB10; CFL1; "]
["Metallopeptidase activity",2,101,0.353356890459364,0.676062881659956,0.801986386459192,1,1,1,"CHMP1A; RCE1; "]
["Peptide hormone",1,45,0.176678445229682,0.762373455906834,0.739705032834691,1,1,1,"NMB; "]
["G-protein coupled receptor activity",4,736,0.706713780918728,0.185104110716815,0.999999569397688,1,1,1,"SLC52A2; TPRA1; DRD4; PAQR4; "]
["Cytoskeletal anchoring activity",2,39,0.353356890459364,1.75055400349839,0.319295152216759,1,1,1,"PLEC; GPAA1; "]
["Lipid transporter activity",1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,1,1,"PITPNM1; "]
["Protein serine/threonine kinase activity",10,301,1.76678445229682,1.12981818240363,0.393600992263022,1,1,1,"RPS6KA4; CDK16; IRAK1; MKNK2; MAP3K11; PLK1; STK25; RPS6KB2; FASTK; PKN1; "]
["Lyase activity",1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"ALDOA; "]
["Transcription regulator activity",32,832,5.65371024734982,1.30711119392752,0.0748040182537825,1,0.874219283677773,1,"TONSL; MAF1; ZFPL1; MRGBP; PRICKLE3; NELFB; RPS6KA4; RUVBL2; MED15; GLI4; ZNF205; NELFA; TRIM28; SCYL1; ZNF593; HES4; MED25; DRAP1; MAD1L1; TSC22D4; NFKBIL1; TRIP6; BRMS1; ZMIZ2; ESRRA; ACD; ZNF282; SCAND1; NFKBIB; BUD31; TAF10; SNAPC2; "]
["Extracellular matrix structural constituent",1,166,0.176678445229682,0.20670097735297,0.993132655790853,1,1,1,"AGRN; "]
["Receptor activity",12,361,2.12014134275618,1.13026214214988,0.374963979773615,1,1,1,"ADRM1; GRINA; CD151; TSPO; RTN4R; FGFRL1; LSR; SIVA1; BSG; GPC1; MBOAT7; TACSTD2; "]
["Glucosidase activity",1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,1,1,"PRKCSH; "]
["Ligand-dependent nuclear receptor activity",2,35,0.353356890459364,1.9505601735639,0.275475664781343,1,1,1,"OGFR; NR1H2; "]
["Transcription factor activity",21,842,3.71024734982332,0.847742993280932,0.81263006084216,1,1,1,"HSF1; SLC2A4RG; NR2F6; GTF2IRD1; TNIP2; GMEB2; PITX1; RELA; MAZ; MAFK; RFXANK; E2F1; MYBL2; LBX2; SMARCA4; RBCK1; AATF; IRF3; GTF3C5; KLF16; NME2; "]
["Oxidoreductase activity",9,161,1.59010600706714,1.90119799179685,0.0489516440580636,1,0.764255432284065,1,"NDUFS8; TSTA3; DOHH; NDUFV1; PRDX5; NDUFB9; COX5B; COX8A; BLVRB; "]
["Calcium ion binding",5,185,0.88339222614841,0.920021398598934,0.638385141545955,1,1,1,"HPCAL1; CIB1; S100A16; ANXA11; S100A11; "]
["Carboxy-lyase activity",1,20,0.176678445229682,1.71486403050308,0.4499798329091,1,1,1,"MVD; "]
["Ubiquitin-specific protease activity",17,377,3.00353356890459,1.53287538279636,0.0549312418461909,1,0.764255432284065,1,"SCRIB; FBXL6; UBE2S; RNF126; TMEM189; UBE2C; OTUB1; TRIM11; UBE2M; DTX2; FBXW5; ZNRF1; PSMA7; PSMC3; PSMD4; RPN1; FBXL8; "]
["Ligase activity",8,112,1.41342756183746,2.42957955747795,0.0176655755107614,1,0.446129147806338,1,"FPGS; CDC34; STUB1; ANAPC11; GYS1; GSS; RNF7; VARS; "]
["Growth factor activity",1,110,0.176678445229682,0.311921000366936,0.962959503436703,1,1,1,"GFER; "]
["Binding",2,22,0.353356890459364,3.10264023973067,0.13587584004334,1,1,1,"GIPC1; RHBDF1; "]
["DNA repair protein",2,57,0.353356890459364,1.19784444266746,0.503273927793011,1,1,1,"XAB2; PNKP; "]
["Acyltransferase activity",6,80,1.06007067137809,2.55202901363447,0.0304618450022575,1,0.568621106708807,1,"DGAT1; PAFAH1B3; COMT; NAA10; TAZ; AGPAT2; "]
["RNA binding",13,366,2.29681978798587,1.20764628934628,0.283392670599413,1,1,1,"LSM4; PUF60; RALY; SNRPA; SCAF1; CPSF1; ZGPAT; PUSL1; DAZAP1; RNPS1; PRPF31; NHP2; SF3A2; "]
["Ribonuclease activity",6,48,1.06007067137809,4.25302731474473,0.00271967733723903,0.609207723541543,0.149787770965499,0.691556285848872,"EXOSC4; EXOSC5; POP7; EXOSC7; RPP21; RNASEH2A; "]
["Methyltransferase activity",1,59,0.176678445229682,0.581501936118736,0.828869745085639,1,1,1,"PRMT1; "]
["DNA binding",23,654,4.06360424028269,1.19532949438799,0.21771712486839,1,1,1,"ZC3H3; RAD23A; ZNF707; H2AFX; CDT1; ZNF598; HMGA1; ZNF787; ZNF579; ZNF524; ZNF408; CHTF18; KIF22; HMG20B; H1FX; HIST2H2AA3; ZNF628; HIST3H2A; XRCC3; ZNF581; ZNF768; DNTTIP1; BANF1; "]
["Chaperone activity",4,126,0.706713780918728,1.08117194293059,0.510315099942699,1,1,1,"PFDN2; CDC37; HSPB1; NAP1L4; "]
["Auxiliary transport protein activity",9,333,1.59010600706714,0.919227316474613,0.649353117076203,1,1,1,"SLC35C2; SLC25A22; SLC16A3; TIMM17B; SLC19A1; GJB3; STX4; SLC4A2; MTX1; "]
["Motor activity",3,79,0.530035335689046,1.29431456907452,0.412077293309858,1,1,1,"MOSPD3; ELMO3; KIFC2; "]
["Isomerase activity",4,45,0.706713780918728,3.02684906751129,0.0427998355890332,1,0.737474090149496,1,"PTGES2; EBP; PPIA; ECI1; "]
["Voltage-gated ion channel activity",1,130,0.176678445229682,0.263936845245493,0.979698022523569,1,1,1,"VDAC2; "]
["DNA-directed RNA polymerase activity",2,29,0.353356890459364,2.35398523531445,0.209694901983121,1,1,1,"POLR2H; POLR2I; "]
["Cysteine-type peptidase activity",1,46,0.176678445229682,0.745803722024921,0.74738431098951,1,1,1,"CAPN1; "]
["DNA-directed DNA polymerase activity",3,20,0.530035335689046,5.11063438793492,0.0199164798127829,1,0.446129147806338,1,"POLD1; POLD4; POLD2; "]
["Peptidase activity",1,58,0.176678445229682,0.591526103264378,0.823663912328349,1,1,1,"NCLN; "]
["Heat shock protein activity",1,27,0.176678445229682,1.27043425584475,0.553885537089529,1,1,1,"TRAP1; "]
["Phosphatase regulator activity",1,16,0.176678445229682,2.14331225798667,0.380095435962882,1,1,1,"PPP1R14B; "]
["Protein tyrosine/serine/threonine phosphatase activity",1,37,0.176678445229682,0.927166421247409,0.669261602400543,1,1,1,"SSH3; "]
["Guanyl-nucleotide exchange factor activity",1,112,0.176678445229682,0.306351479781864,0.965120083508704,1,1,1,"EEF1D; "]
["Intracellular ligand-gated ion channel activity",2,30,0.353356890459364,2.27554520747991,0.220585351103676,1,1,1,"CLIC3; KCNN4; "]
["Phospholipase activity",2,45,0.353356890459364,1.51719865977499,0.383651712974115,1,1,1,"LYPLA2; PLCB3; "]
["Protein threonine/tyrosine kinase activity",2,28,0.353356890459364,2.4380261219733,0.198861779180491,1,1,1,"PKMYT1; MAP2K2; "]
["Cytokine activity",4,107,0.706713780918728,1.27313780514609,0.386749630618156,1,1,1,"MIF; MDK; FBRS; TNFRSF6B; "]
["Enzyme regulator activity",2,13,0.353356890459364,5.24897092055897,0.0544331436114236,1,0.764255432284065,1,"AURKAIP1; DPM2; "]
["Transmembrane receptor activity",1,52,0.176678445229682,0.659765992123949,0.788936490414516,1,1,1,"LTBR; "]
["Galactosyltransferase activity",1,38,0.176678445229682,0.90277372402964,0.679015050694865,1,1,1,"B4GALT2; "]
["Deoxyribonuclease activity",2,17,0.353356890459364,4.01464501331406,0.0879201610243771,1,0.937815050926689,1,"NTHL1; ENDOG; "]
["Helicase activity",2,25,0.353356890459364,2.73047227814763,0.166844808275171,1,1,1,"RECQL4; DDX49; "]
["Ubiquitin binding",3,9,0.530035335689046,11.3500326417955,1.86596638145643E-3,0.417976469446241,0.149787770965499,0.691556285848872,"ANKRD13D; UBXN1; RBCK1; "]
["Aminopeptidase activity",2,29,0.353356890459364,2.35398523531445,0.209694901983121,1,1,1,"RNPEPL1; DPP9; "]
["Ribonucleoprotein",3,41,0.530035335689046,2.4936306779463,0.119169917804716,1,1,1,"RRP9; PTBP1; MRPL28; "]
["Growth factor binding",1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,1,1,"PDAP1; "]
["Nucleocytoplasmic transporter activity",1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.764255432284065,1,"MVP; "]
["Phosphorylase activity",1,20,0.176678445229682,1.71486403050308,0.4499798329091,1,1,1,"PHKG2; "]
["Peroxidase activity",2,20,0.353356890459364,3.412749209219,0.116044284911768,1,1,1,"GPX1; GPX4; "]
["Glutathione transferase activity",1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"GSTP1; "]
["RNA methyltransferase activity",1,12,0.176678445229682,2.85715480852345,0.301349333118106,1,1,1,"TRMT61A; "]
["Peptide binding",2,6,0.353356890459364,11.3625809777824,0.0119906115174986,1,0.446129147806338,1,"BAD; CAPNS1; "]
["Protein serine/threonine phosphatase activity",2,44,0.353356890459364,1.55167261250789,0.373088387777994,1,1,1,"PPP4C; PPP1CA; "]
["Transferase activity, transferring aldehyde or ketonic groups",2,3,0.353356890459364,22.6874125171004,0.00254374438366584,0.569798741941149,0.149787770965499,0.691556285848872,"TALDO1; TKT; "]
["DNA topoisomerase activity",1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,1,1,"TOP1MT; "]
["Catalase activity",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.568621106708807,1,"MGAT4B; "]
["Endonuclease activity",1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,1,1,"TSEN34; "]

{"sheet":"DAVID-GO-BP","index":2,"n_rows":46,"n_cols":10,"rows_kept":46}
["Term","Count",1,2,3,"PValue",4,5,"6","Genes"]
["Biological_process unknown",126,4731,22.2614840989399,0.904912425150984,0.914532352839196,1,1,1,"SHARPIN; MROH1; MFSD10; FAM83H; ADCK5; PPDPF; TBL3; YDJC; CPTP; TMEM134; LRFN4; TSR3; RBM42; GET4; ZDHHC12; CYHR1; TIGD5; CCDC124; SART1; UQCC3; UBALD2; ARRDC1; MED15; ROMO1; MZT2A; CCDC85B; MFSD2B; PWWP2B; INO80B; COMMD5; NOC2L; BOP1; PPP1R35; MZT2B; PSMG3; PERM1; GSDMD; FAM189B; LIME1; REEP4; MXD3; SMPD4; PRR7; CHCHD2; NUDT22; SH3GLB2; NACC1; FAM110A; INF2; PLEKHN1; TMEM44; SAMD10; TRABD; TSNARE1; FAM3A; ZNHIT1; RHBDF1; YIF1B; NMRAL1; DDA1; JOSD2; MANBAL; INO80E; NOC4L; SHKBP1; ZNHIT2; LRRC45; SYTL1; UBALD1; BOLA2; SSNA1; QPCTL; FAM173A; TELO2; CTU1; FAAP20; ABHD11; ABHD16B; DCAF15; MICALL2; DBNDD2; ARPC5L; TMEM223; BCL7C; TMEM259; VAC14; SAMD1; AGTRAP; CTU2; MVB12A; EPS8L1; HGH1; YIPF2; MOB2; USB1; FAM98C; TRAPPC5; ORAI3; ERGIC3; ANKRD13D; UQCC2; TMC6; BRAT1; LRRC14; KRTCAP2; CLPTM1L; WDR34; DYNLRB1; MALSU1; EFHD2; MBOAT7; ATXN2L; RHBDD2; TSSC4; EMC8; FAM207A; PIH1D1; WDR62; CDCA5; BANF1; TPD52L2; RNF181; TMEM160; SERINC2; ANKRD9; PIEZO1; "]
["Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism",114,2828,20.1413427561837,1.36967462752971,0.000228242442103543,0.0406271546944307,0.0406271546944307,0.221110703241583,"HSF1; ZC3H3; TONSL; MAF1; SLC2A4RG; LSM4; ZFPL1; EXOSC4; PUF60; MRGBP; RALY; SNRPA; SCAF1; ZNF707; CPSF1; CDT1; PRICKLE3; ZNF598; NELFB; MACROD1; POLR2H; RPS6KA4; ZGPAT; HMGA1; NR2F6; RUVBL2; ZNF787; GLI4; ZNF579; TOP1MT; ZNF205; UCKL1; POLD1; TRPT1; NELFA; GTF2IRD1; PUSL1; TRIM28; DAZAP1; FPGS; TNIP2; GMEB2; SCYL1; RNPS1; ZNF524; ZNF593; ZNF408; CHTF18; KIF22; HES4; NAPRT; NTHL1; HMG20B; XAB2; TRMT61A; EXOSC5; MED25; RRP9; MRPL12; CDK2AP2; PITX1; PRPF31; RELA; POLD4; POP7; PTBP1; H1FX; EXOSC7; PNKP; RPUSD1; RRP1; DRAP1; HIST2H2AA3; MAZ; TSC22D4; ZNF628; POLR2I; NFKBIL1; GTPBP3; HIST3H2A; MAFK; SIRT6; RFXANK; PARP10; TRIP6; RPP21; NAP1L4; E2F1; ZMIZ2; MYBL2; ZNF581; SIRT7; RNASEH2A; ESRRA; ZNF511; ACD; ZNF282; DDX49; TSEN34; ZNF768; LBX2; SMARCA4; RNH1; RBCK1; NFKBIB; BUD31; POLD2; TAF10; IRF3; GTF3C5; SNAPC2; KLF16; ENDOG; NME2; "]
["Signal transduction",109,3934,19.2579505300353,0.941426211745716,0.778477354906205,1,1,1,"SLC52A2; ADRM1; DVL1; PAM16; MIF; PKP3; HGS; GIPC1; PPP1R16A; GUK1; GRINA; RHOD; CORO1B; GNB2; RANGAP1; RPS6KA4; TRAF7; EPN1; OGFR; ARFRP1; PPP4C; EEF1D; HPCAL1; TSPO; PDAP1; SAC3D1; RAB1B; CDK16; SCYL1; BCAR1; RABL6; EPS8L2; AUP1; AURKAIP1; GNB1L; TBC1D10B; TNK2; AXIN1; TBRG4; IRAK1; GFER; SPNS1; MDK; HRAS; MAP2K2; RASSF7; SH2D3A; RIN1; STXBP2; JUP; RHPN1; STRN4; LTBR; RTN4R; FZR1; GADD45GIP1; NOL3; MAD1L1; RAB11B; AGAP3; MKNK2; POC1A; ZMYND19; MAP3K11; TRAF2; RRAS; NR1H2; GNA15; ITGB4; CIB1; BSG; COPS7B; MVB12A; EPS8L1; PLK1; S100A16; SPSB3; FBRS; PTK6; NUDC; STK25; PEX14; PTOV1; STX4; RPS6KB2; BAIAP2; RHOT2; NMB; CKS1B; TWF2; PKN1; ANXA11; GPC1; ARF5; SLC9A3R2; SIGIRR; SPC24; DRD4; MLST8; TRAF4; WDR74; EFNA4; NME2; RHOC; AP2S1; PAQR4; TACSTD2; S100A11; PITPNM1; "]
["Cell communication",101,3713,17.8445229681979,0.924258935974027,0.828616649330069,1,1,1,"SLC52A2; ADRM1; DVL1; MIF; PKP3; HGS; PPP1R16A; GUK1; RHOD; GNB2; RANGAP1; RPS6KA4; TRAF7; EPN1; OGFR; ARFRP1; PPP4C; EEF1D; HPCAL1; CD151; TSPO; PDAP1; SAC3D1; RAB1B; CDK16; SCYL1; BCAR1; RABL6; EPS8L2; AUP1; AURKAIP1; GNB1L; TBC1D10B; TBRG4; IRAK1; GFER; SPNS1; MDK; HRAS; MAP2K2; RASSF7; SH2D3A; RIN1; STXBP2; JUP; RHPN1; STRN4; LTBR; RTN4R; FZR1; GADD45GIP1; NOL3; MAD1L1; RAB11B; AGAP3; MKNK2; POC1A; ZMYND19; MAP3K11; TRAF2; RRAS; NR1H2; GNA15; ITGB4; GJB3; CIB1; BSG; COPS7B; PLK1; S100A16; SPSB3; FBRS; PTK6; NUDC; STK25; PEX14; ARHGAP39; PTOV1; STX4; BAIAP2; RHOT2; NMB; CKS1B; TWF2; PKN1; ANXA11; GPC1; ARF5; SLC9A3R2; SIGIRR; SPC24; DRD4; MLST8; TRAF4; WDR74; EFNA4; RHOC; AP2S1; TACSTD2; S100A11; PITPNM1; "]
["Metabolism",65,1683,11.4840989399293,1.31234758232044,0.0142925269811409,1,0.424011633773846,1,"ATAD3A; PPP1R14B; ALDOA; NDUFS8; ALG3; PGLS; CYC1; TPRA1; DGAT1; OPLAH; PRKCSH; FPGS; NT5C; MVD; PAFAH1B3; LYPLA2; NDOR1; COMT; ACAD9; DPP9; DGUOK; PTGES2; TSTA3; TALDO1; EBP; NAA10; STUB1; PNPLA2; TK1; DTYMK; NUDT8; PTRH1; BCKDK; POR; B4GALT2; DPM2; PRMT1; ISOC2; NDUFV1; GYS1; GSTP1; NDUFB7; PDF; NDUFS6; GSS; GAPDH; PRDX5; HAGHL; NDUFB9; TAZ; MDH2; COX5B; PLCB3; COX8A; VARS; MECR; BLVRB; ECI1; CYBA; PHKG2; NME3; TKT; ATAD3B; GPX4; COASY; "]
["Energy pathways",64,1633,11.3074204946996,1.33172449776487,0.0112104161324934,1,0.399090814316764,1,"ATAD3A; PPP1R14B; ALDOA; NDUFS8; ALG3; PGLS; CYC1; TPRA1; DGAT1; OPLAH; PRKCSH; FPGS; NT5C; MVD; PAFAH1B3; LYPLA2; NDOR1; COMT; ACAD9; DPP9; DGUOK; PTGES2; TSTA3; TALDO1; EBP; NAA10; STUB1; PNPLA2; TK1; DTYMK; NUDT8; PTRH1; BCKDK; POR; B4GALT2; PRMT1; ISOC2; NDUFV1; GYS1; GSTP1; NDUFB7; PDF; NDUFS6; GSS; GAPDH; PRDX5; HAGHL; NDUFB9; TAZ; MDH2; COX5B; PLCB3; COX8A; VARS; MECR; BLVRB; ECI1; CYBA; PHKG2; NME3; TKT; ATAD3B; GPX4; COASY; "]
["Protein metabolism",57,1323,10.0706713780919,1.46400756238598,0.00245905769072211,0.437712268948536,0.154485378304727,0.840776837423534,"SCRIB; FBXL6; UBE2S; TMUB1; RPL8; CHMP1A; RNF126; TMEM189; GPAA1; RCE1; HSPBP1; MRPL52; UBE2C; RNPEPL1; OTUB1; PFDN2; TRIM11; UBE2M; MRPS34; CDC34; EIF3B; DTX2; MRPL41; BTBD2; CDC37; FBXW5; HSPB1; NCLN; SF3A2; ZNRF1; MRPL28; RPL28; ST14; CAPN1; MRPL23; MRPS12; PSMA7; MRPL55; PRSS8; TUFM; MRPS24; PRSS22; PSMC3; CSTB; NUBP2; MRPL4; SPINT1; SPINT2; RPS6KB2; LONP1; RBCK1; PSMD4; TRAP1; MRPL17; MRPL11; RPN1; FBXL8; "]
["Transport",31,1215,5.47703180212014,0.867116239400114,0.82111823854021,1,1,1,"VPS28; CHMP4B; SLC39A4; NUTF2; ATP6V0C; SLC35C2; SLC25A39; BCAP31; MFSD3; TMEM44; SLC25A22; SLC25A1; SLC16A3; TIMM17B; UNC93B1; NOSIP; SLC19A1; TOMM34; AP2A1; CLIC3; GJB3; KCNN4; YIF1A; VDAC2; STX10; KDELR1; SLC25A10; LMAN2; TOMM40; SLC4A2; MTX1; "]
["Cell growth and/or maintenance",25,1125,4.41696113074205,0.755288226306344,0.94615321447068,1,1,1,"NSUN5; MOSPD3; PAK4; ELMO3; TMEM8A; KATNB1; KIFC2; TUBGCP2; ARPC1A; CEP131; CLTB; LMNB2; ARHGDIA; MVP; ARPC1B; TUBA4A; EMD; TRIP10; MIB2; SSH3; KRT19; AGRN; TMSB10; TPD52L2; CFL1; "]
["Apoptosis",12,220,2.12014134275618,1.85462449860246,0.0301027078146793,1,0.446523499251076,1,"PPP1R13L; BAD; PHLDA2; BCL2L12; BBC3; SIVA1; FKBP8; TNFRSF6B; BIK; FASTK; AATF; TRAF4; "]
["DNA repair",5,58,0.88339222614841,2.93420373995499,0.0276745886503488,1,0.446523499251076,1,"RECQL4; RAD23A; H2AFX; MPG; XRCC3; "]
["Lipid metabolism",5,33,0.88339222614841,5.15641196470127,2.60368615120326E-3,0.46345613491418,0.154485378304727,0.840776837423534,"ACOT8; ARFGAP1; TAZ; AGPAT2; PITPNM1; "]
["Immune response",4,576,0.706713780918728,0.236521026594474,0.999970478146235,1,1,1,"IFRD2; TNFRSF6B; DNTTIP1; LY6E; "]
["Anti-apoptosis",3,32,0.530035335689046,3.19474520782811,0.0670063397820453,1,0.897647930408168,1,"GPX1; TNFRSF6B; RNF7; "]
["Cell cycle",3,22,0.530035335689046,4.64624234904942,0.0257667049640283,1,0.446523499251076,1,"BAD; CDC20; PITPNM1; "]
["RNA metabolism",2,26,0.353356890459364,2.62549448967598,0.177422114173447,1,1,1,"MRPL28; INTS1; "]
["Regulation of gene expression, epigenetic",2,66,0.353356890459364,1.03452676377022,0.582596604904594,1,1,1,"BRMS1; SCAND1; "]
["Protein folding",2,16,0.353356890459364,4.26540360252793,0.0790682638562617,1,0.897647930408168,1,"PPIA; CAPNS1; "]
["Cell motility",2,20,0.353356890459364,3.412749209219,0.116044284911768,1,0.983613462585463,1,"CD151; PAK4; "]
["Transcription",2,46,0.353356890459364,1.48422324878227,0.394137515720453,1,1,1,"ZNF787; INTS1; "]
["Ribosome biogenesis and assembly",2,4,0.353356890459364,17.0297036599681,0.00498824804547824,0.887908152095126,0.221977038023781,1,"NHP2; MRPS12; "]
["Regulation of cell cycle",1,57,0.176678445229682,0.601901933877681,0.818300004914825,1,1,1,"MAD1L1; "]
["Regulation of cell proliferation",1,23,0.176678445229682,1.49128332248442,0.497180927410287,1,1,1,"TRAF4; "]
["Purine salvage",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.446523499251076,1,"APRT; "]
["Proteolysis and peptidolysis",1,16,0.176678445229682,2.14331225798667,0.380095435962882,1,1,1,"UBXN1; "]
["Regulation of cell growth",1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"FGFRL1; "]
["Peptide metabolism",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.983613462585463,1,"PPIA; "]
["Negative regulation of enzyme activity",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.897647930408168,1,"PKMYT1; "]
["Cytoskeleton organization and biogenesis",1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"INF2; "]
["Cell adhesion",1,54,0.176678445229682,0.635334738944021,0.801211193672853,1,1,1,"ITGB4; "]
["Cell proliferation",1,39,0.176678445229682,0.879631613698195,0.688481363805299,1,1,1,"PPP1CA; "]
["Cell differentiation",1,29,0.176678445229682,1.18284830232219,0.579796695995637,1,1,1,"CEP131; "]
["Protein modification",1,20,0.176678445229682,1.71486403050308,0.4499798329091,1,1,1,"DOHH; "]
["Cell-cell signaling",1,16,0.176678445229682,2.14331225798667,0.380095435962882,1,1,1,"ARHGAP39; "]
["Cell migration",1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"ITGB4; "]
["Wound healing",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.897647930408168,1,"ITGB4; "]
["Regulation of translation",1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,1,1,"EIF6; "]
["Cytoskeletal anchoring",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.983613462585463,1,"PLEC; "]
["Regulation of enzyme activity",1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,1,1,"AURKAIP1; "]
["Mitosis",1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,1,1,"ANAPC11; "]
["Protein transport",1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,1,1,"ARFGAP1; "]
["Vesicle docking",1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.983613462585463,1,"SYTL1; "]
["Peroxisome organization and biogenesis",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.446523499251076,1,"PEX16; "]
["Glycoprotein metabolism",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.446523499251076,1,"MGAT4B; "]
["Lipoprotein metabolism",1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.897647930408168,1,"LSR; "]

{"sheet":"DAVID-KEGG","index":3,"n_rows":799,"n_cols":10,"rows_kept":799}
["Term","Count",1,2,"Fold Enrichment","PValue",4,5,"6","Genes"]
["ptr01100:Proteoglycan syndecan-mediated signaling events",56,1342,9.89399293286219,1.41796407082374,0.00521367653938957,1,0.116131802881907,0.437055183012849,"DVL1; HGS; GIPC1; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; MDK; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; BSG; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:IFN-gamma pathway",55,1293,9.71731448763251,1.44542368601949,3.8094218765697E-3,1,0.100858979208226,0.379576812918041,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; PTGES2; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; MAP3K11; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Glypican pathway",55,1335,9.71731448763251,1.39995002304108,0.00721594772353909,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; MDK; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; GPC1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Glypican 1 network",54,1296,9.54063604240283,1.41586299321298,0.00622280192906689,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; GPC1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:PAR1-mediated thrombin signaling events",54,1296,9.54063604240283,1.41586299321298,0.00622280192906689,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; PLCB3; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Syndecan-1-mediated signaling events",54,1297,9.54063604240283,1.41477135707046,0.00631681835198952,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; BSG; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Thrombin/protease-activated receptor (PAR) pathway",54,1297,9.54063604240283,1.41477135707046,0.00631681835198952,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; PLCB3; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Plasma membrane estrogen receptor signaling",54,1298,9.54063604240283,1.41368140294294,6.41204170080595E-3,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; PLCB3; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Endothelins",54,1304,9.54063604240283,1.40717678379304,0.0070094141022907,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; PLCB3; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:LKB1 signaling events",54,1305,9.54063604240283,1.40609849566973,0.00711343096097128,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; CDC37; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:TRAIL signaling pathway",54,1325,9.54063604240283,1.3848745276141,0.00948555306290156,1,0.120777881747479,0.454540426490466,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; LMNB2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Beta1 integrin cell surface interactions",54,1348,9.54063604240283,1.36124553811467,0.0130011524721708,1,0.137252672934057,0.516542330348533,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; MDK; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Integrin family cell surface interactions",54,1375,9.54063604240283,1.33451582012782,0.0184403474678888,1,0.169002744925486,0.636031851569488,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; MDK; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Insulin Pathway",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Internalization of ErbB1",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:PDGFR-beta signaling pathway",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:EGF receptor (ErbB1) signaling pathway",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Class I PI3K signaling events",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Arf6 signaling events",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:mTOR signaling pathway",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Signaling events mediated by focal adhesion kinase",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Arf6 downstream pathway",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:S1P1 pathway",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:ErbB1 downstream signaling",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Arf6 trafficking events",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Class I PI3K signaling events mediated by Akt",53,1285,9.36395759717314,1.40154389102642,0.00811653987835933,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:EGFR-dependent Endothelin signaling events",53,1286,9.36395759717314,1.40045405199637,8.23561338176549E-3,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:IGF1 pathway",53,1288,9.36395759717314,1.39827945078676,0.00847818448630228,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:GMCSF-mediated signaling events",53,1289,9.36395759717314,1.39719468073006,0.00860171006881638,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:IL5-mediated signaling events",53,1289,9.36395759717314,1.39719468073006,0.00860171006881638,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)",53,1290,9.36395759717314,1.39611159247436,0.00872674778559186,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:PDGF receptor signaling network",53,1290,9.36395759717314,1.39611159247436,0.00872674778559186,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Nectin adhesion pathway",53,1292,9.36395759717314,1.39395044574566,0.00898141640993167,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:IL3-mediated signaling events",53,1292,9.36395759717314,1.39395044574566,0.00898141640993167,1,0.116131802881907,0.437055183012849,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Signaling events mediated by VEGFR1 and VEGFR2",53,1293,9.36395759717314,1.3928723794927,9.11107589798015E-3,1,0.116902112291007,0.439954196990209,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:VEGF and VEGFR signaling network",53,1301,9.36395759717314,1.38430751140103,0.0102060714569997,1,0.127997948799064,0.481712722522107,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Alpha9 beta1 integrin signaling events",53,1302,9.36395759717314,1.3832443033524,0.010350381781509,1,0.128839080683262,0.484878272702705,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:ErbB receptor signaling network",53,1308,9.36395759717314,1.37689919450758,0.0112525207722163,1,0.132177497521527,0.49744220735293,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Sphingosine 1-phosphate (S1P) pathway",53,1308,9.36395759717314,1.37689919450758,0.0112525207722163,1,0.132177497521527,0.49744220735293,"DVL1; HGS; ALDOA; RPS6KA4; HMGA1; EPN1; RUVBL2; MED15; PPP1CA; PPP1R13L; BAD; TRIM28; BCAR1; PAK4; AXIN1; RELA; ARFGAP1; CLTB; HRAS; MAP2K2; RIN1; HSPB1; JUP; ARHGDIA; BBC3; ARPC1B; TK1; AP2A1; TRAF2; RRAS; TRIP6; GNA15; GYS1; ITGB4; GPX1; E2F1; PLK1; FKBP8; KDELR1; TRIP10; GAPDH; SMARCA4; STX4; BAIAP2; KRT19; DYNLRB1; NFKBIB; PKN1; ARF5; TAF10; SLC9A3R2; MLST8; NME2; "]
["ptr01100:Metabolism",43,823,7.59717314487632,1.77549615575364,0.000205057382885541,0.342035714653082,0.033729892479488,0.12694045872703,"LSM4; EXOSC4; RPL8; GUK1; GNB2; APRT; NDUFS8; CYC1; UBE2C; OPLAH; FPGS; NT5C; RNPS1; NAPRT; COMT; EXOSC5; DGUOK; HSPB1; EXOSC7; NOSIP; SLC19A1; TALDO1; FZR1; RPL28; TK1; DTYMK; ANAPC11; PSMA7; NDUFV1; GSTP1; GPX1; BSG; NDUFB7; PSMC3; NDUFS6; GSS; NDUFB9; MDH2; COX5B; PSMD4; COX8A; TKT; COASY; "]
["ptr01100:Cell Cycle, Mitotic",30,1208,5.30035335689046,0.844016373711664,0.857509827823794,1,1,1,"HGS; ATP6V0C; EPN1; PPP1CA; UBE2C; BAD; BCAR1; AXIN1; IRAK1; RELA; HRAS; MAP2K2; FZR1; ARHGDIA; ANAPC11; AP2A1; PSMA7; GNA15; ITGB4; BSG; PSMC3; RPS6KB2; PLCB3; NMB; PSMD4; AATF; DRD4; MLST8; RHOC; AP2S1; "]
["ptr01100:Mesenchymal-to-epithelial transition",29,755,5.12367491166078,1.30542050725331,0.0876505562637403,1,0.445735145877801,1,"ALDOA; RPS6KA4; RUVBL2; MED15; PPP1CA; BAD; BCAR1; PAK4; TNK2; AXIN1; RELA; HRAS; MAP2K2; HSPB1; ARHGDIA; ARPC1B; MAP3K11; TRAF2; TRIP6; ITGB4; E2F1; FKBP8; SMARCA4; BAIAP2; KRT19; DYNLRB1; PKN1; CYBA; CFL1; "]
["ptr01100:DNA Replication",29,768,5.12367491166078,1.2833238332591,0.102430000701149,1,0.502509532851519,1,"ALDOA; RPS6KA4; RUVBL2; MED15; PPP1CA; BAD; BCAR1; PAK4; TNK2; AXIN1; RELA; HRAS; MAP2K2; HSPB1; ARHGDIA; ARPC1B; MAP3K11; TRAF2; TRIP6; ITGB4; E2F1; FKBP8; SMARCA4; BAIAP2; KRT19; DYNLRB1; PKN1; CYBA; CFL1; "]
["ptr01100:Gene Expression",24,317,4.24028268551237,2.57320628702815,2.49406767777641e-05,0.0416010488653106,0.0208005244326553,0.0782815455118861,"PKMYT1; CDT1; RANGAP1; UBE2C; POLD1; TUBGCP2; POLD4; CEP131; FZR1; MAD1L1; SSNA1; ANAPC11; TUBA4A; PSMA7; E2F1; PLK1; MYBL2; PSMC3; NUDC; PSMD4; CKS1B; POLD2; SPC24; CDC20; "]
["ptr01100:HIV Infection",23,223,4.06360424028269,3.50548155968203,1.9791970320982e-07,0.000330130064953979,0.000330130064953979,1.24242500655248E-3,"PKP3; RHOD; PHLDA2; EPS8L2; ELMO3; COMT; SH2D3A; JUP; ST14; CAPN1; LSR; ABHD11; PRSS8; ITGB4; EPS8L1; PTK6; BIK; SPINT1; SPINT2; SSH3; TMC6; KRT19; TACSTD2; "]
["ptr01100:Mitotic M-M/G1 phases",22,654,3.886925795053,1.1433812330065,0.289629768593719,1,0.916702948793781,1,"PPP1R14B; ALDOA; RPS6KA4; RUVBL2; MED15; PPP1CA; BAD; AXIN1; RELA; CDC37; HRAS; MAP2K2; HSPB1; TRAF2; TRIP6; ITGB4; E2F1; FKBP8; SMARCA4; KRT19; DYNLRB1; PKN1; "]
["ptr01100:TNF alpha/NF-kB",20,261,3.53356890459364,2.60462585857389,9.86032231683387e-05,0.164470176244789,0.0309405905061215,0.116443085447745,"CDT1; RANGAP1; UBE2C; POLD1; POLD4; CEP131; FZR1; MAD1L1; SSNA1; ANAPC11; TUBA4A; PSMA7; E2F1; PLK1; PSMC3; NUDC; PSMD4; POLD2; SPC24; CDC20; "]
["ptr01100:Metabolism of mRNA",20,621,3.53356890459364,1.09472213868758,0.371783537457581,1,1,1,"ALDOA; RPS6KA4; RUVBL2; MED15; PPP1CA; BAD; AXIN1; RELA; HRAS; MAP2K2; HSPB1; TRAF2; TRIP6; ITGB4; E2F1; FKBP8; SMARCA4; KRT19; DYNLRB1; PKN1; "]
["ptr01100:Metabolism of RNA",18,378,3.18021201413428,1.61869799871475,0.0316646004426588,1,0.23001125514377,0.865633777459743,"SNRPA; RPL8; CPSF1; NELFB; POLR2H; MED15; EEF1D; NELFA; TRIM28; RNPS1; EIF3B; MED25; PTBP1; SF3A2; RPL28; POLR2I; VARS; TAF10; "]
["ptr01100:Host Interactions of HIV factors",17,203,3.00353356890459,2.84670384743636,1.11297088151516E-4,0.185643543036729,0.0309405905061215,0.116443085447745,"NELFB; RANGAP1; POLR2H; HMGA1; UBE2C; NELFA; FZR1; ANAPC11; POLR2I; AP2A1; PSMA7; PSMC3; PPIA; PSMD4; TAF10; AP2S1; BANF1; "]
["ptr01100:Apoptosis",17,242,3.00353356890459,2.38795648141835,0.000864150980358622,1,0.0739193902117428,0.278191260408175,"CDT1; RANGAP1; UBE2C; CEP131; FZR1; MAD1L1; SSNA1; ANAPC11; TUBA4A; PSMA7; E2F1; PLK1; PSMC3; NUDC; PSMD4; SPC24; CDC20; "]
["ptr01100:S Phase",17,432,3.00353356890459,1.33772215473729,0.138884892032538,1,0.595526992057256,1,"RPL8; RPS6KA4; MED15; MED25; RELA; HRAS; MAP2K2; DRAP1; RPL28; AP2A1; RRAS; ARHGAP39; AGRN; GPC1; RHOC; AP2S1; CFL1; "]
["ptr01100:Mitotic G1-G1/S phases",17,522,3.00353356890459,1.10708482226022,0.369350869765942,1,1,1,"UBE2C; PRKCSH; TNIP2; IRAK1; RELA; HRAS; MAP2K2; FZR1; ANAPC11; PSMA7; TRAF2; PSMC3; PSMD4; NFKBIB; IRF3; SIGIRR; MLST8; "]
["ptr01100:Signalling by NGF",15,171,2.65017667844523,2.98204773531281,0.000167048780665475,0.278637366150012,0.0332024056663879,0.124955293251982,"RPL8; POLR2H; PPP1R13L; PFDN2; TNIP2; CDC34; RELA; CDC37; HSPB1; TRAF2; PSMC3; RPS6KB2; NFKBIB; PKN1; TRAF4; "]
["ptr01100:M Phase",14,234,2.47349823321555,2.03403829233682,0.00970907945644754,1,0.122687458586019,0.461727006169193,"LSM4; EXOSC4; RPL8; UBE2C; RNPS1; EXOSC5; HSPB1; EXOSC7; FZR1; RPL28; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Mitotic G2-G2/M phases",14,281,2.47349823321555,1.6938375886614,0.0392875758465126,1,0.267836875358688,1,"LSM4; EXOSC4; RPL8; UBE2C; RNPS1; EXOSC5; HSPB1; EXOSC7; FZR1; RPL28; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Regulation of mRNA Stability by Proteins that Bind AU-rich Elements",13,375,2.29681978798587,1.17866355127499,0.312714268691465,1,0.964043156151442,1,"BCAR1; KIF22; HMG20B; SLC16A3; HRAS; TUBA4A; MAFK; GNA15; BSG; PPIA; STX4; AP2S1; CFL1; "]
["ptr01100:Synthesis of DNA",12,141,2.12014134275618,2.89366666149583,0.00095681795796564,1,0.0739193902117428,0.278191260408175,"RANGAP1; HMGA1; UBE2C; FZR1; ANAPC11; AP2A1; PSMA7; PSMC3; PPIA; PSMD4; AP2S1; BANF1; "]
["ptr01100:G1/S Transition",12,158,2.12014134275618,2.5823424842575,0.00252665563759726,1,0.0891367369122622,0.33546084619019,"PLEC; UBE2C; BAD; BCAP31; FZR1; BBC3; ANAPC11; PSMA7; TRAF2; E2F1; PSMC3; PSMD4; "]
["ptr01100:The citric acid (TCA) cycle and respiratory electron transport",12,259,2.12014134275618,1.57536749908315,0.0821304092797327,1,0.430841458886192,1,"RPL8; ALG3; GPAA1; EEF1D; PFDN2; PRKCSH; EIF3B; RPL28; DOHH; DPM2; MGAT4B; RPN1; "]
["ptr01100:Formation and Maturation of mRNA Transcript",12,305,2.12014134275618,1.33777887917618,0.190241562156563,1,0.711486380442035,1,"RPS6KA4; MED15; PPP1CA; BAD; AXIN1; HSPB1; TRAF2; E2F1; FKBP8; KRT19; DYNLRB1; PKN1; "]
["ptr01100:G2/M Transition",12,305,2.12014134275618,1.33777887917618,0.190241562156563,1,0.711486380442035,1,"RPS6KA4; MED15; PPP1CA; BAD; AXIN1; HSPB1; TRAF2; E2F1; FKBP8; KRT19; DYNLRB1; PKN1; "]
["ptr01100:Signaling by EGFR",12,305,2.12014134275618,1.33777887917618,0.190241562156563,1,0.711486380442035,1,"RPS6KA4; MED15; PPP1CA; BAD; AXIN1; HSPB1; TRAF2; E2F1; FKBP8; KRT19; DYNLRB1; PKN1; "]
["ptr01100:HIV Life Cycle",12,321,2.12014134275618,1.27110038920136,0.238589083379629,1,0.805600386795994,1,"RPS6KA4; MED15; PPP1CA; BAD; AXIN1; HSPB1; TRAF2; E2F1; FKBP8; KRT19; DYNLRB1; PKN1; "]
["ptr01100:DNA Repair",12,324,2.12014134275618,1.25933130439655,0.248148804618742,1,0.834500415532383,1,"RPS6KA4; MED15; PPP1CA; BAD; AXIN1; HSPB1; TRAF2; E2F1; FKBP8; KRT19; DYNLRB1; PKN1; "]
["ptr01100:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1",11,121,1.9434628975265,3.09115985051997,0.000896597193101222,1,0.0739193902117428,0.278191260408175,"CDT1; UBE2C; POLD1; POLD4; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; CKS1B; POLD2; "]
["ptr01100:Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins",11,140,1.9434628975265,2.67167526256283,0.00289387389605686,1,0.0958240614091539,0.360628197073629,"PKMYT1; CDT1; UBE2C; FZR1; ANAPC11; PSMA7; E2F1; MYBL2; PSMC3; PSMD4; CKS1B; "]
["ptr01100:Respiratory electron transport",11,143,1.9434628975265,2.615630050426,0.0034079720215373,1,0.0958240614091539,0.360628197073629,"BAD; IRAK1; RELA; HRAS; MAP2K2; ARHGDIA; AP2A1; RPS6KB2; AATF; MLST8; AP2S1; "]
["ptr01100:Regulation of APC/C activators between G1/S and early anaphase",11,158,1.9434628975265,2.36732645725854,0.00717647313580227,1,0.116131802881907,0.437055183012849,"RANGAP1; UBE2C; CEP131; MAD1L1; SSNA1; ANAPC11; TUBA4A; PLK1; NUDC; SPC24; CDC20; "]
["ptr01100:Cyclin E associated events during G1/S transition",11,219,1.9434628975265,1.707964264241,0.0599152769089147,1,0.343431896508831,1,"RPS6KA4; HRAS; MAP2K2; AP2A1; RRAS; ARHGAP39; AGRN; GPC1; RHOC; AP2S1; CFL1; "]
["ptr01100:Regulation of mitotic cell cycle",11,299,1.9434628975265,1.25099914220736,0.267408452192824,1,0.862741389279749,1,"RPS6KA4; BAD; RELA; MAP2K2; LMNB2; HSPB1; TRAF2; E2F1; FKBP8; KRT19; PKN1; "]
["ptr01100:APC/C-mediated degradation of cell cycle proteins",11,307,1.9434628975265,1.21840087785877,0.295582050379615,1,0.928495028311106,1,"H2AFX; PPP1R13L; TRIM28; BBC3; TK1; XRCC3; GPX1; E2F1; PLK1; MYBL2; SMARCA4; "]
["ptr01100:Assembly of the pre-replicative complex",10,99,1.76678445229682,3.43487093309076,0.000670794928729779,1,0.0699303713200795,0.263178823345517,"PKMYT1; UBE2C; TUBGCP2; CEP131; FZR1; SSNA1; ANAPC11; TUBA4A; E2F1; PLK1; "]
["ptr01100:Regulation of DNA replication",10,104,1.76678445229682,3.26974878459106,0.000986333239255961,1,0.0739193902117428,0.278191260408175,"EXOSC4; UBE2C; EXOSC5; HSPB1; EXOSC7; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Cyclin A:Cdk2-associated events at S phase entry",10,109,1.76678445229682,3.11977406738204,1.41426805900254E-3,1,0.0842499686577227,0.317069782408971,"CDT1; UBE2C; POLD1; POLD4; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; POLD2; "]
["ptr01100:Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.",10,117,1.76678445229682,2.90647441317252,2.40295984958146E-3,1,0.0891367369122622,0.33546084619019,"PKMYT1; CDT1; UBE2C; FZR1; ANAPC11; PSMA7; E2F1; PSMC3; PSMD4; CKS1B; "]
["ptr01100:DNA Replication Pre-Initiation",10,118,1.76678445229682,2.88184536128562,0.00255813685858253,1,0.0891367369122622,0.33546084619019,"NDUFS8; CYC1; NDUFV1; BSG; NDUFB7; NDUFS6; NDUFB9; MDH2; COX5B; COX8A; "]
["ptr01100:M/G1 Transition",10,185,1.76678445229682,1.83820642714078,0.0475000532124461,1,0.304467315590135,1,"SNRPA; CPSF1; NELFB; POLR2H; NELFA; RNPS1; PTBP1; SF3A2; POLR2I; TAF10; "]
["ptr01100:Mitotic Prometaphase",10,234,1.76678445229682,1.45329930808648,0.153863741571482,1,0.643219851983038,1,"RPS6KA4; BAD; IRAK1; RELA; HSPB1; TRAF2; E2F1; FKBP8; KRT19; PKN1; "]
["ptr01100:p63 transcription factor network",9,96,1.59010600706714,3.18833338880545,0.00208032714479379,1,0.0889739917311806,0.334848364310662,"PKMYT1; UBE2C; TUBGCP2; CEP131; FZR1; SSNA1; ANAPC11; TUBA4A; PLK1; "]
["ptr01100:Cell Cycle Checkpoints",9,98,1.59010600706714,3.12327199937977,2.39812534304552E-3,1,0.0891367369122622,0.33546084619019,"HGS; EPN1; BAD; HRAS; MAP2K2; AP2A1; RPS6KB2; MLST8; AP2S1; "]
["ptr01100:Metabolism of nucleotides",9,103,1.59010600706714,2.97167157226688,0.00336272967552476,1,0.0958240614091539,0.360628197073629,"NELFB; RANGAP1; POLR2H; HMGA1; NELFA; POLR2I; PPIA; TAF10; BANF1; "]
["ptr01100:APC/C:Cdc20 mediated degradation of Securin",9,106,1.59010600706714,2.88757559342714,0.00407350697581441,1,0.10549098084233,0.397009077566231,"H2AFX; POLR2H; MPG; POLD1; NTHL1; XAB2; POLD4; POLR2I; POLD2; "]
["ptr01100:SCF(Skp2)-mediated degradation of p27/p21",9,178,1.59010600706714,1.71963310296731,0.0807897104192339,1,0.426446952466083,1,"CPSF1; NELFB; POLR2H; NELFA; RNPS1; POLR2I; TAF10; GTF3C5; SNAPC2; "]
["ptr01100:Cdc20:Phospho-APC/C mediated degradation of Cyclin A",9,178,1.59010600706714,1.71963310296731,0.0807897104192339,1,0.426446952466083,1,"GIPC1; BAD; IRAK1; RELA; HRAS; RTN4R; ARHGDIA; E2F1; RHOC; "]
["ptr01100:SCF-beta-TrCP mediated degradation of Emi1",9,190,1.59010600706714,1.6110304123952,0.109386779477773,1,0.517518786712169,1,"HGS; BAD; BCAR1; RELA; HRAS; PLCB3; MLST8; RHOC; CFL1; "]
["ptr01100:APC/C:Cdc20 mediated degradation of mitotic proteins",9,205,1.59010600706714,1.49315588829428,0.152065447568555,1,0.637299413428015,1,"RUVBL2; BCAR1; ARHGDIA; ARPC1B; MAP3K11; BAIAP2; PKN1; CYBA; CFL1; "]
["ptr01100:Destabilization of mRNA by AUF1 (hnRNP D0)",9,205,1.59010600706714,1.49315588829428,0.152065447568555,1,0.637299413428015,1,"RUVBL2; BCAR1; ARHGDIA; ARPC1B; MAP3K11; BAIAP2; PKN1; CYBA; CFL1; "]
["ptr01100:CDT1 association with the CDC6:ORC:origin complex",9,205,1.59010600706714,1.49315588829428,0.152065447568555,1,0.637299413428015,1,"RUVBL2; BCAR1; ARHGDIA; ARPC1B; MAP3K11; BAIAP2; PKN1; CYBA; CFL1; "]
["ptr01100:Signaling by Wnt",9,205,1.59010600706714,1.49315588829428,0.152065447568555,1,0.637299413428015,1,"RUVBL2; BCAR1; ARHGDIA; ARPC1B; MAP3K11; BAIAP2; PKN1; CYBA; CFL1; "]
["ptr01100:Degradation of beta-catenin by the destruction complex",9,226,1.59010600706714,1.35441745347202,0.223271710492918,1,0.789019519284293,1,"RPS6KA4; PPP1CA; BAD; HSPB1; TRAF2; E2F1; FKBP8; KRT19; PKN1; "]
["ptr01100:Switching of origins to a post-replicative state",9,250,1.59010600706714,1.2243985786937,0.316742887115924,1,0.964043156151442,1,"H2AFX; PPP1R13L; TRIM28; BBC3; XRCC3; GPX1; E2F1; PLK1; SMARCA4; "]
["ptr01100:Orc1 removal from chromatin",9,275,1.59010600706714,1.1130936644457,0.420839960201716,1,1,1,"DVL1; HGS; RUVBL2; PAK4; AXIN1; HRAS; JUP; SMARCA4; STX4; "]
["ptr01100:Removal of licensing factors from origins",9,275,1.59010600706714,1.1130936644457,0.420839960201716,1,1,1,"DVL1; HGS; RUVBL2; PAK4; AXIN1; HRAS; JUP; SMARCA4; STX4; "]
["ptr01100:Metabolism of carbohydrates",9,280,1.59010600706714,1.09321770172212,0.441806125039569,1,1,1,"DVL1; HGS; RUVBL2; PAK4; AXIN1; HRAS; JUP; SMARCA4; STX4; "]
["ptr01100:LPA receptor mediated events",8,69,1.41342756183746,3.94344596773084,0.000924921200944612,1,0.0739193902117428,0.278191260408175,"UBE2C; FZR1; ANAPC11; PSMA7; PLK1; PSMC3; PSMD4; CDC20; "]
["ptr01100:RNA Polymerase II Transcription",8,72,1.41342756183746,3.77915853677413,0.00122612573725927,1,0.0785628228708437,0.295666545043985,"UBE2C; FZR1; ANAPC11; PSMA7; PLK1; PSMC3; PSMD4; CDC20; "]
["ptr01100:PLK1 signaling events",8,76,1.41342756183746,3.58028162390614,1.74391294134294E-3,1,0.0855543172400005,0.321978621281641,"NDUFS8; CYC1; NDUFV1; NDUFB7; NDUFS6; NDUFB9; COX5B; COX8A; "]
["ptr01100:NGF signalling via TRKA from the plasma membrane",8,78,1.41342756183746,3.48849129897584,0.00206058809730979,1,0.0889739917311806,0.334848364310662,"UBE2C; FZR1; ANAPC11; PSMA7; PLK1; PSMC3; PSMD4; CDC20; "]
["ptr01100:mRNA Splicing - Major Pathway",8,78,1.41342756183746,3.48849129897584,0.00206058809730979,1,0.0889739917311806,0.334848364310662,"PKMYT1; UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; CKS1B; "]
["ptr01100:mRNA Splicing",8,81,1.41342756183746,3.35930386659802,0.00261852524502449,1,0.0891367369122622,0.33546084619019,"UBE2C; FZR1; ANAPC11; PSMA7; PLK1; PSMC3; PSMD4; CDC20; "]
["ptr01100:Polo-like kinase signaling events in the cell cycle",8,81,1.41342756183746,3.35930386659802,0.00261852524502449,1,0.0891367369122622,0.33546084619019,"UBE2C; FZR1; ANAPC11; PSMA7; PLK1; PSMC3; PSMD4; CDC20; "]
["ptr01100:Transcription-coupled NER (TC-NER)",8,83,1.41342756183746,3.27836653696067,3.05162191525749E-3,1,0.0958240614091539,0.360628197073629,"CDT1; UBE2C; FZR1; ANAPC11; PSMA7; E2F1; PSMC3; PSMD4; "]
["ptr01100:Telomere Maintenance",8,88,1.41342756183746,3.09211687573123,0.00437909714796064,1,0.109019911086542,0.410289998170662,"CDT1; UBE2C; FZR1; ANAPC11; PSMA7; E2F1; PSMC3; PSMD4; "]
["ptr01100:Nucleotide Excision Repair",8,90,1.41342756183746,3.02341080138991,0.00501950326544923,1,0.11469221159958,0.4316373662241,"CDT1; UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; CKS1B; "]
["ptr01100:Autodegradation of Cdh1 by Cdh1:APC/C",8,91,1.41342756183746,2.99019015748935,0.00536540715174837,1,0.116131802881907,0.437055183012849,"NDUFS8; CYC1; NDUFV1; NDUFB7; NDUFS6; NDUFB9; COX5B; COX8A; "]
["ptr01100:Ubiquitin-dependent degradation of Cyclin D",8,98,1.41342756183746,2.77662693840532,0.00832057793926685,1,0.116131802881907,0.437055183012849,"CDT1; UBE2C; FZR1; ANAPC11; PSMA7; E2F1; PSMC3; PSMD4; "]
["ptr01100:Ubiquitin-dependent degradation of Cyclin D1",8,98,1.41342756183746,2.77662693840532,0.00832057793926685,1,0.116131802881907,0.437055183012849,"CDT1; UBE2C; FZR1; ANAPC11; PSMA7; E2F1; PSMC3; PSMD4; "]
["ptr01100:CDK-mediated phosphorylation and removal of Cdc6",8,99,1.41342756183746,2.74858303437133,0.00882604779039295,1,0.116131802881907,0.437055183012849,"RANGAP1; UBE2C; MAD1L1; ANAPC11; PLK1; NUDC; SPC24; CDC20; "]
["ptr01100:Regulation of activated PAK-2p34 by proteasome mediated degradation",8,105,1.41342756183746,2.59153610354352,0.0123539401098582,1,0.137252672934057,0.516542330348533,"ADRM1; DVL1; NOC2L; AXIN1; BBC3; ITGB4; PLK1; TRAF4; "]
["ptr01100:Vpu mediated degradation of CD4",8,118,1.41342756183746,2.30605208230748,0.0233806780870806,1,0.192113157878081,0.723006526136195,"UBE2C; FZR1; MAD1L1; ANAPC11; PSMA7; PSMC3; PSMD4; CDC20; "]
["ptr01100:Cross-presentation of soluble exogenous antigens (endosomes)",8,138,1.41342756183746,1.97186585198975,0.0515268594673746,1,0.319504838630412,1,"PLEC; EPN1; BCAR1; TNK2; HRAS; MAP2K2; AP2A1; PTK6; "]
["ptr01100:Autodegradation of the E3 ubiquitin ligase COP1",8,149,1.41342756183746,1.8263016323274,0.0736691503259523,1,0.404210995867396,1,"HMGA1; RUVBL2; AXIN1; TK1; ITGB4; GAPDH; TAF10; NME2; "]
["ptr01100:Vif-mediated degradation of APOBEC3G",8,183,1.41342756183746,1.48700730142126,0.172848182061858,1,0.686454208759951,1,"PRKCSH; IRAK1; RELA; MAP2K2; TRAF2; NFKBIB; IRF3; SIGIRR; "]
["ptr01100:Chromosome Maintenance",8,189,1.41342756183746,1.43980321799431,0.194704175081136,1,0.726547123121553,1,"RPS6KA4; BAD; HSPB1; TRAF2; E2F1; FKBP8; KRT19; PKN1; "]
["ptr01100:Stabilization of p53",8,231,1.41342756183746,1.17803214680363,0.37070244052703,1,1,1,"DVL1; HGS; RUVBL2; PAK4; AXIN1; HRAS; JUP; SMARCA4; "]
["ptr01100:Ubiquitin Mediated Degradation of Phosphorylated Cdc25A",8,237,1.41342756183746,1.14820980647696,0.397541839006245,1,1,1,"UBE2C; RELA; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; MLST8; "]
["ptr01100:Antigen processing: Ubiquitination & Proteasome degradation",8,251,1.41342756183746,1.0841687830489,0.460059571690395,1,1,1,"DVL1; HGS; RUVBL2; PAK4; AXIN1; HRAS; JUP; SMARCA4; "]
["ptr01100:Recruitment of mitotic centrosome proteins and complexes",8,257,1.41342756183746,1.05885843443098,0.486523683836075,1,1,1,"PPP1CA; DGAT1; ACOT8; MVD; SLC25A1; EBP; ECI1; AGPAT2; "]
["ptr01100:Centrosome maturation",7,58,1.23674911660777,4.10554255830029,0.00151076141778324,1,0.0852489839022879,0.320829517293911,"GUK1; APRT; NT5C; DGUOK; TK1; DTYMK; GPX1; "]
["ptr01100:p53-Independent G1/S DNA damage checkpoint",7,66,1.23674911660777,3.60797642489017,0.00319943240196216,1,0.0958240614091539,0.360628197073629,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; CDC20; "]
["ptr01100:p53-Independent DNA Damage Response",7,67,1.23674911660777,3.55413406666169,0.00348410072727808,1,0.0958240614091539,0.360628197073629,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; CKS1B; "]
["ptr01100:Regulation of ornithine decarboxylase (ODC)",7,69,1.23674911660777,3.45113061595421,4.1108595651987E-3,1,0.10549098084233,0.397009077566231,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; CDC20; "]
["ptr01100:p53-Dependent G1 DNA Damage Response",7,70,1.23674911660777,3.40183579212969,0.0044545253759595,1,0.109266887163242,0.411219478052339,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; CDC20; "]
["ptr01100:p53-Dependent G1/S DNA damage checkpoint",7,71,1.23674911660777,3.35392935934375,0.00481944328985132,1,0.11469221159958,0.4316373662241,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; CDC20; "]
["ptr01100:Activated TLR4 signalling",7,71,1.23674911660777,3.35392935934375,0.00481944328985132,1,0.11469221159958,0.4316373662241,"UBE2C; HSPB1; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Downstream signal transduction",7,74,1.23674911660777,3.21797762203756,0.00604975617461375,1,0.116131802881907,0.437055183012849,"CDT1; UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Regulation of Apoptosis",7,75,1.23674911660777,3.17507697383015,0.00650774611627904,1,0.116131802881907,0.437055183012849,"UBE2C; AXIN1; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:G1/S DNA Damage Checkpoints",7,75,1.23674911660777,3.17507697383015,0.00650774611627904,1,0.116131802881907,0.437055183012849,"UBE2C; AXIN1; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Toll Like Receptor 4 (TLR4) Cascade",7,83,1.23674911660777,2.86908232510541,0.0111504965262032,1,0.132177497521527,0.49744220735293,"CDT1; UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Signaling by PDGF",7,83,1.23674911660777,2.86908232510541,0.0111504965262032,1,0.132177497521527,0.49744220735293,"CDT1; UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:ER-Phagosome pathway",7,85,1.23674911660777,2.80158244685331,0.0126125365284762,1,0.137252672934057,0.516542330348533,"CDT1; UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Validated targets of C-MYC transcriptional activation",7,92,1.23674911660777,2.58844173249647,0.0188171178325565,1,0.171214836675423,0.644356928254924,"PGLS; SLC25A1; TALDO1; MDH2; SLC25A10; PHKG2; TKT; "]
["ptr01100:Antigen processing-Cross presentation",7,100,1.23674911660777,2.38138709936006,0.0282188569347974,1,0.216908080033374,0.81632075162351,"BCAR1; RELA; HRAS; TRIP6; GNA15; PLCB3; SLC9A3R2; "]
["ptr01100:Toll Receptor Cascades",7,101,1.23674911660777,2.35781134350064,0.0295826278880168,1,0.219305881409831,0.825344735522922,"CPSF1; NELFB; POLR2H; NELFA; RNPS1; POLR2I; TAF10; "]
["ptr01100:Removal of DNA patch containing abasic residue",7,104,1.23674911660777,2.28980409390443,0.0339385089736704,1,0.241920653709753,0.910454095758958,"AURKAIP1; RELA; FZR1; PLK1; NUDC; SPC24; CDC20; "]
["ptr01100:Resolution of AP sites via the multiple-nucleotide patch replacement pathway",7,107,1.23674911660777,2.22560997857209,0.0387011235318182,1,0.267836875358688,1,"BAD; HRAS; MAP2K2; AP2A1; RPS6KB2; MLST8; AP2S1; "]
["ptr01100:Base Excision Repair",7,107,1.23674911660777,2.22560997857209,0.0387011235318182,1,0.267836875358688,1,"SNRPA; CPSF1; POLR2H; RNPS1; PTBP1; SF3A2; POLR2I; "]
["ptr01100:Resolution of Abasic Sites (AP sites)",7,107,1.23674911660777,2.22560997857209,0.0387011235318182,1,0.267836875358688,1,"SNRPA; CPSF1; POLR2H; RNPS1; PTBP1; SF3A2; POLR2I; "]
["ptr01100:Phosphorylation of Emi1",7,109,1.23674911660777,2.18477684439042,0.0421077663895331,1,0.279823722461121,1,"AURKAIP1; RELA; FZR1; PLK1; NUDC; SPC24; CDC20; "]
["ptr01100:Extension of Telomeres",7,114,1.23674911660777,2.08896170342075,0.0514549510424276,1,0.319504838630412,1,"ALG3; GPAA1; PRKCSH; DOHH; DPM2; MGAT4B; RPN1; "]
["ptr01100:Response to elevated platelet cytosolic Ca2+",7,138,1.23674911660777,1.72569033988117,0.113326942264865,1,0.522180496402748,1,"BCAR1; TUBA4A; GNA15; PPIA; STX4; AP2S1; CFL1; "]
["ptr01100:p75 NTR receptor-mediated signalling",7,138,1.23674911660777,1.72569033988117,0.113326942264865,1,0.522180496402748,1,"SNRPA; CPSF1; POLR2H; RNPS1; PTBP1; SF3A2; POLR2I; "]
["ptr01100:Validated transcriptional targets of TAp63 isoforms",7,157,1.23674911660777,1.51686213494045,0.181216274604137,1,0.710523864594637,1,"SNRPA; CPSF1; POLR2H; RNPS1; PTBP1; SF3A2; POLR2I; "]
["ptr01100:RNA Polymerase II Pre-transcription Events",7,188,1.23674911660777,1.2667545545822,0.317715109531938,1,0.964043156151442,1,"GNB2; COMT; HRAS; RRAS; KCNN4; PLCB3; AP2S1; "]
["ptr01100:Transcription of the HIV genome",6,44,1.06007067137809,4.639578309041,0.0017271863022008,1,0.0855543172400005,0.321978621281641,"POLR2H; POLD1; XAB2; POLD4; POLR2I; POLD2; "]
["ptr01100:MyD88:Mal cascade initiated on plasma membrane",6,49,1.06007067137809,4.16624854888583,0.00302355875047556,1,0.0958240614091539,0.360628197073629,"RUVBL2; POLD1; NHP2; POLD4; ACD; POLD2; "]
["ptr01100:Toll Like Receptor TLR1:TLR2 Cascade",6,49,1.06007067137809,4.16624854888583,0.00302355875047556,1,0.0958240614091539,0.360628197073629,"POLR2H; POLD1; XAB2; POLD4; POLR2I; POLD2; "]
["ptr01100:Toll Like Receptor TLR6:TLR2 Cascade",6,60,1.06007067137809,3.40256359574895,0.0082580955447069,1,0.116131802881907,0.437055183012849,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Toll Like Receptor 2 (TLR2) Cascade",6,66,1.06007067137809,3.09328649266618,0.0129411891641281,1,0.137252672934057,0.516542330348533,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Downstream signaling of activated FGFR",6,66,1.06007067137809,3.09328649266618,0.0129411891641281,1,0.137252672934057,0.516542330348533,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Signaling by SCF-KIT",6,66,1.06007067137809,3.09328649266618,0.0129411891641281,1,0.137252672934057,0.516542330348533,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase",6,66,1.06007067137809,3.09328649266618,0.0129411891641281,1,0.137252672934057,0.516542330348533,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Mitotic Telophase /Cytokinesis",6,67,1.06007067137809,3.04712492733763,0.0138713945840485,1,0.143074364772837,0.538451923835426,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Phosphorylation of the APC/C",6,67,1.06007067137809,3.04712492733763,0.0138713945840485,1,0.143074364772837,0.538451923835426,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Polo-like kinase mediated events",6,68,1.06007067137809,3.00232085547558,0.0148472409870934,1,0.150501594596366,0.566403864727121,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Mitotic Spindle Checkpoint",6,69,1.06007067137809,2.95881526417757,0.0158697535040587,1,0.155710287322176,0.586006472247574,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Arf1 pathway",6,69,1.06007067137809,2.95881526417757,0.0158697535040587,1,0.155710287322176,0.586006472247574,"RUVBL2; POLD1; NHP2; POLD4; ACD; POLD2; "]
["ptr01100:Homologous Recombination Repair",6,69,1.06007067137809,2.95881526417757,0.0158697535040587,1,0.155710287322176,0.586006472247574,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Homologous recombination repair of replication-independent double-strand breaks",6,69,1.06007067137809,2.95881526417757,0.0158697535040587,1,0.155710287322176,0.586006472247574,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Abortive elongation of HIV-1 transcript in the absence of Tat",6,69,1.06007067137809,2.95881526417757,0.0158697535040587,1,0.155710287322176,0.586006472247574,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Purine metabolism",6,70,1.06007067137809,2.91655251222532,0.0169399311398939,1,0.156976695229683,0.590772523630994,"TUBGCP2; CEP131; FZR1; SSNA1; TUBA4A; PLK1; "]
["ptr01100:EGFR downregulation",6,70,1.06007067137809,2.91655251222532,0.0169399311398939,1,0.156976695229683,0.590772523630994,"TUBGCP2; CEP131; FZR1; SSNA1; TUBA4A; PLK1; "]
["ptr01100:Double-Strand Break Repair",6,70,1.06007067137809,2.91655251222532,0.0169399311398939,1,0.156976695229683,0.590772523630994,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Pausing and recovery of Tat-mediated HIV-1 elongation",6,70,1.06007067137809,2.91655251222532,0.0169399311398939,1,0.156976695229683,0.590772523630994,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Tat-mediated HIV-1 elongation arrest and recovery",6,70,1.06007067137809,2.91655251222532,0.0169399311398939,1,0.156976695229683,0.590772523630994,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Elongation arrest and recovery",6,72,1.06007067137809,2.83554841523253,0.0192271389906693,1,0.171501967039767,0.645437526427196,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Pausing and recovery of HIV-1 elongation",6,72,1.06007067137809,2.83554841523253,0.0192271389906693,1,0.171501967039767,0.645437526427196,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:HIV-1 elongation arrest and recovery",6,72,1.06007067137809,2.83554841523253,0.0192271389906693,1,0.171501967039767,0.645437526427196,"IRAK1; RELA; MAP2K2; NFKBIB; IRF3; SIGIRR; "]
["ptr01100:Pausing and recovery of elongation",6,75,1.06007067137809,2.72214159953199,0.0230387650412066,1,0.190240891528379,0.71596036227917,"BAD; BCAR1; HRAS; MAP2K2; RPS6KB2; MLST8; "]
["ptr01100:Formation of the HIV-1 Early Elongation Complex",6,75,1.06007067137809,2.72214159953199,0.0230387650412066,1,0.190240891528379,0.71596036227917,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Formation of the Early Elongation Complex",6,76,1.06007067137809,2.68632865913557,0.0244142848839626,1,0.198648913104632,0.747603455020285,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Signal transduction by L1",6,76,1.06007067137809,2.68632865913557,0.0244142848839626,1,0.198648913104632,0.747603455020285,"IRAK1; RELA; MAP2K2; NFKBIB; IRF3; SIGIRR; "]
["ptr01100:Glucose metabolism",6,78,1.06007067137809,2.61745726677214,0.0273275303669337,1,0.212010793730444,0.797890103788223,"BAD; BCAR1; HRAS; MAP2K2; RPS6KB2; MLST8; "]
["ptr01100:Phase II conjugation",6,80,1.06007067137809,2.55202901363447,0.0304618450022575,1,0.224824590547635,0.846114071504647,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:HIV-1 Transcription Elongation",6,81,1.06007067137809,2.52052637181699,0.0321135635961368,1,0.230885448613604,0.868923752965725,"HMGA1; RUVBL2; TK1; GAPDH; TAF10; NME2; "]
["ptr01100:Tat-mediated elongation of the HIV-1 transcript",6,86,1.06007067137809,2.37400117871055,0.0412405271033918,1,0.27515679683383,1,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Formation of HIV-1 elongation complex containing HIV-1 Tat",6,90,1.06007067137809,2.26850173737245,0.0496111982324133,1,0.309930631654178,1,"IRAK1; RELA; MAP2K2; NFKBIB; IRF3; SIGIRR; "]
["ptr01100:Formation of HIV-1 elongation complex in the absence of HIV-1 Tat",6,92,1.06007067137809,2.21919184198342,0.0541601729901111,1,0.330161758341289,1,"NELFB; RANGAP1; POLR2H; NELFA; POLR2I; TAF10; "]
["ptr01100:Formation of RNA Pol II elongation complex",6,101,1.06007067137809,2.0214616511325,0.0776624753801768,1,0.420587691344594,1,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:RNA Polymerase II Transcription Elongation",6,121,1.06007067137809,1.68736336981154,0.147040138851571,1,0.624078757263158,1,"GNB2; COMT; HRAS; RRAS; PLCB3; AP2S1; "]
["ptr01100:Deadenylation-dependent mRNA decay",6,164,1.06007067137809,1.24497190037738,0.353097438883268,1,1,1,"RPS6KA4; BAD; HSPB1; E2F1; FKBP8; KRT19; "]
["ptr01100:Metabolism of vitamins and cofactors",6,188,1.06007067137809,1.08604777076163,0.478592459395114,1,1,1,"UBE2C; FZR1; ANAPC11; PSMA7; PSMC3; PSMD4; "]
["ptr01100:Metabolism of water-soluble vitamins and cofactors",6,189,1.06007067137809,1.08030179028038,0.483712005652649,1,1,1,"PPP1R13L; TRIM28; BBC3; GPX1; E2F1; SMARCA4; "]
["ptr01100:APOBEC3G mediated resistance to HIV-1 infection",6,193,1.06007067137809,1.05791327589707,0.50402797394661,1,1,1,"TNIP2; IRAK1; RELA; HRAS; MAP2K2; IRF3; "]
["ptr01100:Resolution of D-loop structures through Holliday junction intermediates",6,209,1.06007067137809,0.976928574617934,0.582011224702558,1,1,1,"DVL1; GIPC1; RUVBL2; AXIN1; MDK; SMARCA4; "]
["ptr01100:Resolution of D-loop structures",6,800,1.06007067137809,0.255231611330976,0.999997406166396,1,1,1,"PPP1CA; GNA15; PLCB3; NMB; DRD4; RHOC; "]
["ptr01100:Pentose phosphate pathway (hexose monophosphate shunt)",5,17,0.88339222614841,10.0066524958724,1.0010541631116E-4,0.166975834407014,0.0309405905061215,0.116443085447745,"MPG; POLD1; NTHL1; POLD4; POLD2; "]
["ptr01100:Integration of provirus",5,17,0.88339222614841,10.0066524958724,1.0010541631116E-4,0.166975834407014,0.0309405905061215,0.116443085447745,"MPG; POLD1; NTHL1; POLD4; POLD2; "]
["ptr01100:Type I hemidesmosome assembly",5,19,0.88339222614841,8.95387474775322,0.000179149670861805,0.298821650997492,0.0332024056663879,0.124955293251982,"MPG; POLD1; NTHL1; POLD4; POLD2; "]
["ptr01100:Basigin interactions",5,19,0.88339222614841,8.95387474775322,0.000179149670861805,0.298821650997492,0.0332024056663879,0.124955293251982,"MPG; POLD1; NTHL1; POLD4; POLD2; "]
["ptr01100:Removal of the Flap Intermediate from the C-strand",5,20,0.88339222614841,8.50640474536675,0.000233113931075793,0.388834037034423,0.033729892479488,0.12694045872703,"UBE2C; FZR1; ANAPC11; PLK1; CDC20; "]
["ptr01100:pentose phosphate pathway",5,28,0.88339222614841,6.0768710801424,1.2166952344835E-3,1,0.0785628228708437,0.295666545043985,"RUVBL2; POLD1; NHP2; POLD4; POLD2; "]
["ptr01100:Early Phase of HIV Life Cycle",5,39,0.88339222614841,4.36332117289897,5.46702030524919E-3,1,0.116131802881907,0.437055183012849,"TUBA4A; PPIA; STX4; AP2S1; CFL1; "]
["ptr01100:Processive synthesis on the C-strand of the telomere",5,39,0.88339222614841,4.36332117289897,5.46702030524919E-3,1,0.116131802881907,0.437055183012849,"BAD; IRAK1; RELA; ARHGDIA; AATF; "]
["ptr01100:mRNA Decay by 3' to 5' Exoribonuclease",5,54,0.88339222614841,3.15151192288074,0.0209961738652207,1,0.180422390531471,0.679009013521763,"NOC2L; BBC3; ITGB4; PLK1; TRAF4; "]
["ptr01100:TRAF6 mediated NF-kB activation",5,58,0.88339222614841,2.93420373995499,0.0276745886503488,1,0.213709323466582,0.804282420158579,"NELFB; POLR2H; NELFA; POLR2I; TAF10; "]
["ptr01100:Polymerase switching on the C-strand of the telomere",5,60,0.88339222614841,2.83641324703864,0.0314657638272373,1,0.23001125514377,0.865633777459743,"NELFB; POLR2H; NELFA; POLR2I; TAF10; "]
["ptr01100:Removal of the Flap Intermediate",5,62,0.88339222614841,2.74493080075454,0.0355668688819227,1,0.249266963424567,0.938101498599522,"IRAK1; RELA; MAP2K2; NFKBIB; SIGIRR; "]
["ptr01100:Polymerase switching",5,64,0.88339222614841,2.65916511411949,0.0399828429042646,1,0.267836875358688,1,"IRAK1; RELA; MAP2K2; NFKBIB; SIGIRR; "]
["ptr01100:Leading Strand Synthesis",5,64,0.88339222614841,2.65916511411949,0.0399828429042646,1,0.267836875358688,1,"IRAK1; RELA; MAP2K2; NFKBIB; SIGIRR; "]
["ptr01100:guanosine nucleotides de novo biosynthesis",5,65,0.88339222614841,2.61826117450836,0.0423101152386198,1,0.280052667531817,1,"IRAK1; RELA; MAP2K2; NFKBIB; SIGIRR; "]
["ptr01100:pyrimidine deoxyribonucleotides de novo biosynthesis",5,66,0.88339222614841,2.57859656044219,0.0447174042607065,1,0.292504432575916,1,"BAD; HRAS; MAP2K2; RPS6KB2; MLST8; "]
["ptr01100:Processive synthesis on the lagging strand",5,66,0.88339222614841,2.57859656044219,0.0447174042607065,1,0.292504432575916,1,"BAD; HRAS; MAP2K2; RPS6KB2; MLST8; "]
["ptr01100:Repair synthesis of patch ~27-30 bases long by DNA polymerase",5,77,0.88339222614841,2.21027345740539,0.0765053857762496,1,0.418396667130441,1,"ALG3; PRKCSH; DPM2; MGAT4B; RPN1; "]
["ptr01100:Repair synthesis for gap-filling by DNA polymerase in TC-NER",5,78,0.88339222614841,2.18194025067028,0.0798737320403362,1,0.424297404596436,1,"RELA; CDC37; STUB1; PRMT1; COX5B; "]
["ptr01100:Glutathione conjugation",5,84,0.88339222614841,2.02610592732757,0.101700128628075,1,0.500400632895661,1,"VPS28; CHMP4B; HGS; ARFGAP1; STX4; "]
["ptr01100:salvage pathways of pyrimidine ribonucleotides",5,89,0.88339222614841,1.91229253965609,0.121917636065605,1,0.554110672908525,1,"GNB2; HRAS; RRAS; PLCB3; AP2S1; "]
["ptr01100:Gap-filling DNA repair synthesis and ligation in TC-NER",5,92,0.88339222614841,1.84994195147037,0.134878505858395,1,0.595526992057256,1,"TNIP2; IRAK1; RELA; HRAS; MAP2K2; "]
["ptr01100:Gap-filling DNA repair synthesis and ligation in GG-NER",5,95,0.88339222614841,1.79152888069455,0.148423845952672,1,0.628352728550907,1,"BAD; HRAS; MAP2K2; RPS6KB2; MLST8; "]
["ptr01100:Destabilization of mRNA by Tristetraprolin (TTP)",5,130,0.88339222614841,1.30923128186131,0.336613141798653,1,0.997000532372441,1,"BAD; RELA; MAP2K2; LMNB2; TRAF2; "]
["ptr01100:Activation of BH3-only proteins",5,216,0.88339222614841,0.787987403151654,0.765674278095502,1,1,1,"RPL8; ARFGAP1; RPL28; YIF1A; RPN1; "]
["ptr01100:Inactivation of APC/C via direct inhibition of the APC/C complex",4,16,0.706713780918728,8.50958629161044,1.0192721671883E-3,1,0.0739193902117428,0.278191260408175,"UBE2C; FZR1; ANAPC11; CDC20; "]
["ptr01100:Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components",4,18,0.706713780918728,7.56460169509624,1.63547211323334E-3,1,0.0852489839022879,0.320829517293911,"UBE2C; ANAPC11; PLK1; NUDC; "]
["ptr01100:Destabilization of mRNA by KSRP",4,18,0.706713780918728,7.56460169509624,1.63547211323334E-3,1,0.0852489839022879,0.320829517293911,"UBE2C; FZR1; ANAPC11; PLK1; "]
["ptr01100:Lagging Strand Synthesis",4,18,0.706713780918728,7.56460169509624,1.63547211323334E-3,1,0.0852489839022879,0.320829517293911,"PKMYT1; UBE2C; ANAPC11; PLK1; "]
["ptr01100:Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)",4,19,0.706713780918728,7.16667419929948,0.00202382476444273,1,0.0889739917311806,0.334848364310662,"UBE2C; MAD1L1; ANAPC11; CDC20; "]
["ptr01100:Gluconeogenesis",4,20,0.706713780918728,6.80851956665084,2.47150247299824E-3,1,0.0891367369122622,0.33546084619019,"ARFGAP1; CLTB; AP2A1; KDELR1; "]
["ptr01100:PIP3 activates AKT signaling",4,22,0.706713780918728,6.18984445836816,3.5618056399086E-3,1,0.0958240614091539,0.360628197073629,"H2AFX; POLD1; POLD4; POLD2; "]
["ptr01100:Mitotic Metaphase/Anaphase Transition",4,22,0.706713780918728,6.18984445836816,3.5618056399086E-3,1,0.0958240614091539,0.360628197073629,"H2AFX; POLD1; POLD4; POLD2; "]
["ptr01100:APC/C:Cdc20 mediated degradation of Cyclin B",4,23,0.706713780918728,5.92083774570549,0.00421264686859878,1,0.106465075406406,0.400675024941619,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Telomere C-strand (Lagging Strand) Synthesis",4,24,0.706713780918728,5.67423892247743,0.00493921400108934,1,0.11469221159958,0.4316373662241,"APRT; NT5C; DGUOK; GPX1; "]
["ptr01100:APC-Cdc20 mediated degradation of Nek2A",4,27,0.706713780918728,5.0440013524133,0.00761019857201117,1,0.116131802881907,0.437055183012849,"HGS; EPN1; AP2A1; AP2S1; "]
["ptr01100:PI-3K cascade",4,27,0.706713780918728,5.0440013524133,0.00761019857201117,1,0.116131802881907,0.437055183012849,"H2AFX; POLD1; POLD4; POLD2; "]
["ptr01100:Platelet degranulation",4,30,0.706713780918728,4.5397692945246,0.0110886849341346,1,0.132177497521527,0.49744220735293,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Dual incision reaction in TC-NER",4,30,0.706713780918728,4.5397692945246,0.0110886849341346,1,0.132177497521527,0.49744220735293,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Formation of transcription-coupled NER (TC-NER) repair complex",4,31,0.706713780918728,4.39337234855476,0.0124416422359614,1,0.137252672934057,0.516542330348533,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Endosomal Sorting Complex Required For Transport (ESCRT)",4,31,0.706713780918728,4.39337234855476,0.0124416422359614,1,0.137252672934057,0.516542330348533,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Triglyceride Biosynthesis",4,31,0.706713780918728,4.39337234855476,0.0124416422359614,1,0.137252672934057,0.516542330348533,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Insulin effects increased synthesis of Xylulose-5-Phosphate",4,31,0.706713780918728,4.39337234855476,0.0124416422359614,1,0.137252672934057,0.516542330348533,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Autointegration results in viral DNA circles",4,32,0.706713780918728,4.25612235328595,0.0138957116865705,1,0.143074364772837,0.538451923835426,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Activation of PUMA and translocation to mitochondria",4,32,0.706713780918728,4.25612235328595,0.0138957116865705,1,0.143074364772837,0.538451923835426,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Telomere Extension By Telomerase",4,35,0.706713780918728,3.89141606765733,0.0188870083622769,1,0.171214836675423,0.644356928254924,"RPS6KA4; MAP2K2; AP2A1; AP2S1; "]
["ptr01100:Glutathione synthesis and recycling",4,36,0.706713780918728,3.78335119490928,0.0207669651603838,1,0.180422390531471,0.679009013521763,"SLC25A1; MDH2; SLC25A10; PHKG2; "]
["ptr01100:pentose phosphate pathway (non-oxidative branch)",4,39,0.706713780918728,3.49239878309878,0.027077246488014,1,0.21155650038981,0.796180397625012,"OPLAH; COMT; GSTP1; GSS; "]
["ptr01100:Nef Mediated CD8 Down-regulation",4,41,0.706713780918728,3.32207940816102,0.0318540767015653,1,0.23001125514377,0.865633777459743,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:MEK activation",4,41,0.706713780918728,3.32207940816102,0.0318540767015653,1,0.23001125514377,0.865633777459743,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:RAF phosphorylates MEK",4,41,0.706713780918728,3.32207940816102,0.0318540767015653,1,0.23001125514377,0.865633777459743,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:2-LTR circle formation",4,42,0.706713780918728,3.24300110756209,0.0344158995438053,1,0.242218229700706,0.911574005430197,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Purine salvage",4,42,0.706713780918728,3.24300110756209,0.0344158995438053,1,0.242218229700706,0.911574005430197,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Inactivation of Cdc42 and Rac",4,42,0.706713780918728,3.24300110756209,0.0344158995438053,1,0.242218229700706,0.911574005430197,"NELFB; POLR2H; NELFA; POLR2I; "]
["ptr01100:Disinhibition of SNARE formation",4,46,0.706713780918728,2.96106230229696,0.0458276534174432,1,0.298595804298028,1,"LSM4; EXOSC4; EXOSC5; EXOSC7; "]
["ptr01100:NRAGE signals death through JNK",4,47,0.706713780918728,2.89807437840211,0.0489718252640999,1,0.307086483235033,1,"FPGS; NAPRT; SLC19A1; COASY; "]
["ptr01100:Signaling by Rho GTPases",4,47,0.706713780918728,2.89807437840211,0.0489718252640999,1,0.307086483235033,1,"FPGS; NAPRT; SLC19A1; COASY; "]
["ptr01100:Rho GTPase cycle",4,49,0.706713780918728,2.77980976389886,0.0556075892521801,1,0.33360879060725,1,"BAD; RELA; MAP2K2; TRAF2; "]
["ptr01100:Base-Excision Repair, AP Site Formation",4,56,0.706713780918728,2.43239558165833,0.0823971375208005,1,0.430841458886192,1,"RELA; MAP2K2; NFKBIB; IRF3; "]
["ptr01100:Metabolism of folate and pterines",4,56,0.706713780918728,2.43239558165833,0.0823971375208005,1,0.430841458886192,1,"RELA; MAP2K2; NFKBIB; IRF3; "]
["ptr01100:Nef Mediated CD4 Down-regulation",4,58,0.706713780918728,2.34853433078233,0.0910309808911736,1,0.461518772420904,1,"RELA; MAP2K2; NFKBIB; IRF3; "]
["ptr01100:Displacement of DNA glycosylase by APE1",4,59,0.706713780918728,2.30873540973874,0.0955036492127038,1,0.479819538815632,1,"IRAK1; RELA; MAP2K2; NFKBIB; "]
["ptr01100:gamma-glutamyl cycle",4,59,0.706713780918728,2.30873540973874,0.0955036492127038,1,0.479819538815632,1,"IRAK1; RELA; MAP2K2; NFKBIB; "]
["ptr01100:glutathione redox reactions I",4,60,0.706713780918728,2.27026289832833,0.100077783887864,1,0.495340485237262,1,"IRAK1; RELA; MAP2K2; NFKBIB; "]
["ptr01100:pyrimidine ribonucleotides interconversion",4,60,0.706713780918728,2.27026289832833,0.100077783887864,1,0.495340485237262,1,"IRAK1; RELA; MAP2K2; NFKBIB; "]
["ptr01100:Base-free sugar-phosphate removal via the single-nucleotide replacement pathway",4,60,0.706713780918728,2.27026289832833,0.100077783887864,1,0.495340485237262,1,"IRAK1; RELA; MAP2K2; NFKBIB; "]
["ptr01100:RAF/MAP kinase cascade",4,61,0.706713780918728,2.23305157398268,0.104751506420189,1,0.509136626853179,1,"CEP131; SSNA1; TUBA4A; PLK1; "]
["ptr01100:Retrograde neurotrophin signalling",4,61,0.706713780918728,2.23305157398268,0.104751506420189,1,0.509136626853179,1,"CEP131; SSNA1; TUBA4A; PLK1; "]
["ptr01100:Purine catabolism",4,62,0.706713780918728,2.19704042136241,0.109522860737048,1,0.517518786712169,1,"CEP131; SSNA1; TUBA4A; PLK1; "]
["ptr01100:TAK1 activates NFkB by phosphorylation and activation of IKKs complex",4,62,0.706713780918728,2.19704042136241,0.109522860737048,1,0.517518786712169,1,"CEP131; SSNA1; TUBA4A; PLK1; "]
["ptr01100:pyrimidine ribonucleotides de novo biosynthesis",4,62,0.706713780918728,2.19704042136241,0.109522860737048,1,0.517518786712169,1,"IRAK1; RELA; MAP2K2; NFKBIB; "]
["ptr01100:Recruitment of NuMA to mitotic centrosomes",4,65,0.706713780918728,2.09565415364841,0.12440209765146,1,0.563866029572379,1,"IRAK1; RELA; MAP2K2; NFKBIB; "]
["ptr01100:Resolution of AP sites via the single-nucleotide replacement pathway",4,67,0.706713780918728,2.0331066486895,0.134770858938589,1,0.595526992057256,1,"RELA; TRAF2; NFKBIB; IRF3; "]
["ptr01100:Uncoating of the HIV Virion",4,69,0.706713780918728,1.9741845606243,0.145477773022857,1,0.621476840265754,1,"PLEC; CD151; JUP; ITGB4; "]
["ptr01100:Reverse Transcription of HIV RNA",4,72,0.706713780918728,1.89193829369092,0.162130405887987,1,0.659655826934316,1,"SLC16A3; HRAS; BSG; PPIA; "]
["ptr01100:Minus-strand DNA synthesis",4,73,0.706713780918728,1.86602488054627,0.167829399588178,1,0.668113218408306,1,"TRIM28; TK1; E2F1; MYBL2; "]
["ptr01100:Plus-strand DNA synthesis",4,78,0.706713780918728,1.74642323456843,0.197321846317318,1,0.730619928795283,1,"HSF1; RELA; BBC3; PLK1; "]
["ptr01100:adenine and adenosine salvage I",4,79,0.706713780918728,1.72431940929861,0.203401936659701,1,0.744022873571012,1,"RPS6KA4; MAP2K2; AP2A1; AP2S1; "]
["ptr01100:L-dopa degradation",4,79,0.706713780918728,1.72431940929861,0.203401936659701,1,0.744022873571012,1,"ATP6V0C; HRAS; MAP2K2; MLST8; "]
[null,4,83,0.706713780918728,1.64122968953961,0.228241946926497,1,0.797814180635796,1,"DGAT1; SLC25A1; ECI1; AGPAT2; "]
[null,4,98,0.706713780918728,1.39004669450753,0.326409351897683,1,0.973972806735842,1,"RPL8; POLR2H; RPL28; POLR2I; "]
[null,4,98,0.706713780918728,1.39004669450753,0.326409351897683,1,0.973972806735842,1,"OPLAH; COMT; GSTP1; GSS; "]
[null,4,113,0.706713780918728,1.20554354949724,0.426648402711538,1,1,1,"RANGAP1; RELA; RFXANK; SIRT7; "]
[null,4,115,0.706713780918728,1.1845793976931,0.439810462515074,1,1,1,"RELA; HRAS; MAP2K2; E2F1; "]
[null,4,117,0.706713780918728,1.16433190777441,0.452883130869533,1,1,1,"RPL8; EEF1D; EIF3B; RPL28; "]
[null,4,117,0.706713780918728,1.16433190777441,0.452883130869533,1,1,1,"PLEC; CD151; JUP; ITGB4; "]
[null,4,130,0.706713780918728,1.04790767270736,0.534955418977941,1,1,1,"HRAS; MAP2K2; ZMIZ2; PKN1; "]
[null,4,134,0.706713780918728,1.0166291808722,0.558962072817199,1,1,1,"HRAS; MAP2K2; ITGB4; E2F1; "]
[null,4,135,0.706713780918728,1.00909915212713,0.564858644204639,1,1,1,"RPL8; POLR2H; RPL28; POLR2I; "]
[null,4,138,0.706713780918728,0.987163803555418,0.582284887480402,1,1,1,"BBC3; GPX1; E2F1; SMARCA4; "]
[null,4,140,0.706713780918728,0.973062470742684,0.593676651714793,1,1,1,"RPL8; POLR2H; RPL28; POLR2I; "]
[null,4,155,0.706713780918728,0.878901209784422,0.672974107617624,1,1,1,"DVL1; RUVBL2; AXIN1; SMARCA4; "]
[null,4,182,0.706713780918728,0.748521930271322,0.787129829317346,1,1,1,"DVL1; RUVBL2; AXIN1; SMARCA4; "]
[null,4,200,0.706713780918728,0.68115832472718,0.843846781340895,1,1,1,"DVL1; RUVBL2; AXIN1; SMARCA4; "]
[null,4,206,0.706713780918728,0.661319724909874,0.859689084342095,1,1,1,"DVL1; RUVBL2; AXIN1; SMARCA4; "]
[null,4,378,0.706713780918728,0.360409715427325,0.996172335880799,1,1,1,"SLC39A4; ATP6V0C; SLC16A3; SLC4A2; "]
["ptr01100:",3,5,0.530035335689046,20.4119349506143,0.000242661096974734,0.404758709753855,0.033729892479488,0.12694045872703,"HMGA1; PPIA; BANF1; "]
["ptr01100:",3,6,0.530035335689046,17.0156063398632,0.000474694997169628,0.791791255278939,0.0527860836852626,0.198657309135672,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,6,0.530035335689046,17.0156063398632,0.000474694997169628,0.791791255278939,0.0527860836852626,0.198657309135672,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,6,0.530035335689046,17.0156063398632,0.000474694997169628,0.791791255278939,0.0527860836852626,0.198657309135672,"PGLS; TALDO1; TKT; "]
["ptr01100:",3,8,0.530035335689046,12.7670154934554,0.0012717003702115,1,0.0785628228708437,0.295666545043985,"HMGA1; PPIA; BANF1; "]
["ptr01100:",3,8,0.530035335689046,12.7670154934554,0.0012717003702115,1,0.0785628228708437,0.295666545043985,"PLEC; CD151; ITGB4; "]
["ptr01100:",3,9,0.530035335689046,11.3500326417955,1.86596638145643E-3,1,0.0889266264076952,0.334670107712464,"SLC16A3; BSG; PPIA; "]
["ptr01100:",3,10,0.530035335689046,10.2161632470108,2.60764280037984E-3,1,0.0891367369122622,0.33546084619019,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,10,0.530035335689046,10.2161632470108,2.60764280037984E-3,1,0.0891367369122622,0.33546084619019,"PGLS; TALDO1; TKT; "]
["ptr01100:",3,11,0.530035335689046,9.28826467779997,0.00350758146789466,1,0.0958240614091539,0.360628197073629,"HMGA1; PPIA; BANF1; "]
["ptr01100:",3,11,0.530035335689046,9.28826467779997,0.00350758146789466,1,0.0958240614091539,0.360628197073629,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,11,0.530035335689046,9.28826467779997,0.00350758146789466,1,0.0958240614091539,0.360628197073629,"EXOSC4; EXOSC5; EXOSC7; "]
["ptr01100:",3,13,0.530035335689046,7.86039923924502,5.81899543413621E-3,1,0.116131802881907,0.437055183012849,"RELA; TRAF2; NFKBIB; "]
["ptr01100:",3,14,0.530035335689046,7.2993429052518,0.00724577274413812,1,0.116131802881907,0.437055183012849,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,14,0.530035335689046,7.2993429052518,0.00724577274413812,1,0.116131802881907,0.437055183012849,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,14,0.530035335689046,7.2993429052518,0.00724577274413812,1,0.116131802881907,0.437055183012849,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,14,0.530035335689046,7.2993429052518,0.00724577274413812,1,0.116131802881907,0.437055183012849,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,14,0.530035335689046,7.2993429052518,0.00724577274413812,1,0.116131802881907,0.437055183012849,"GUK1; NME2; NME3; "]
["ptr01100:",3,14,0.530035335689046,7.2993429052518,0.00724577274413812,1,0.116131802881907,0.437055183012849,"DTYMK; NME2; NME3; "]
["ptr01100:",3,15,0.530035335689046,6.81304424400917,0.00886157676322405,1,0.116131802881907,0.437055183012849,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,15,0.530035335689046,6.81304424400917,0.00886157676322405,1,0.116131802881907,0.437055183012849,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,15,0.530035335689046,6.81304424400917,0.00886157676322405,1,0.116131802881907,0.437055183012849,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,15,0.530035335689046,6.81304424400917,0.00886157676322405,1,0.116131802881907,0.437055183012849,"OPLAH; GSTP1; GSS; "]
["ptr01100:",3,15,0.530035335689046,6.81304424400917,0.00886157676322405,1,0.116131802881907,0.437055183012849,"UCKL1; NME2; NME3; "]
["ptr01100:",3,16,0.530035335689046,6.38749494706919,0.0106713393628675,1,0.130880838656346,0.492562308276507,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,16,0.530035335689046,6.38749494706919,0.0106713393628675,1,0.130880838656346,0.492562308276507,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,17,0.530035335689046,6.01198084083349,0.01267903507468,1,0.137252672934057,0.516542330348533,"EXOSC4; EXOSC5; EXOSC7; "]
["ptr01100:",3,17,0.530035335689046,6.01198084083349,0.01267903507468,1,0.137252672934057,0.516542330348533,"BAD; BBC3; E2F1; "]
["ptr01100:",3,18,0.530035335689046,5.678167357167,0.0148877476669067,1,0.150501594596366,0.566403864727121,"UBE2C; ANAPC11; CDC20; "]
["ptr01100:",3,18,0.530035335689046,5.678167357167,0.0148877476669067,1,0.150501594596366,0.566403864727121,"UBE2C; ANAPC11; CDC20; "]
["ptr01100:",3,19,0.530035335689046,5.37947365084575,0.0172997332103533,1,0.15942516571751,0.599987197739231,"EXOSC4; EXOSC5; EXOSC7; "]
["ptr01100:",3,20,0.530035335689046,5.11063438793492,0.0199164798127829,1,0.174845728040642,0.658021573517852,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,20,0.530035335689046,5.11063438793492,0.0199164798127829,1,0.174845728040642,0.658021573517852,"EXOSC4; EXOSC5; EXOSC7; "]
["ptr01100:",3,20,0.530035335689046,5.11063438793492,0.0199164798127829,1,0.174845728040642,0.658021573517852,"SLC25A1; MDH2; SLC25A10; "]
["ptr01100:",3,21,0.530035335689046,4.86738667789518,0.022738764147168,1,0.189641292987381,0.713703808574093,"BAD; RPS6KB2; MLST8; "]
["ptr01100:",3,22,0.530035335689046,4.64624234904942,0.0257667049640283,1,0.206629153269227,0.777636617677461,"UBE2C; ANAPC11; PLK1; "]
["ptr01100:",3,22,0.530035335689046,4.64624234904942,0.0257667049640283,1,0.206629153269227,0.777636617677461,"UBE2C; ANAPC11; CDC20; "]
["ptr01100:",3,22,0.530035335689046,4.64624234904942,0.0257667049640283,1,0.206629153269227,0.777636617677461,"POLD1; POLD4; POLD2; "]
["ptr01100:",3,23,0.530035335689046,4.4443196046318,0.0289998136787827,1,0.219172052607028,0.824841078725648,"UBE2C; ANAPC11; CDC20; "]
["ptr01100:",3,27,0.530035335689046,3.78614565355712,0.0439555048452526,1,0.289793605066725,1,"BAD; RPS6KB2; MLST8; "]
["ptr01100:",3,28,0.530035335689046,3.650974441363,0.0481890715322517,1,0.304467315590135,1,"TUBA4A; PPIA; CFL1; "]
["ptr01100:",3,28,0.530035335689046,3.650974441363,0.0481890715322517,1,0.304467315590135,1,"POLR2H; XAB2; POLR2I; "]
["ptr01100:",3,28,0.530035335689046,3.650974441363,0.0481890715322517,1,0.304467315590135,1,"POLR2H; XAB2; POLR2I; "]
["ptr01100:",3,28,0.530035335689046,3.650974441363,0.0481890715322517,1,0.304467315590135,1,"VPS28; CHMP4B; HGS; "]
["ptr01100:",3,28,0.530035335689046,3.650974441363,0.0481890715322517,1,0.304467315590135,1,"DGAT1; SLC25A1; AGPAT2; "]
[null,3,29,0.530035335689046,3.52512216830671,0.0526146213242708,1,0.323842023501416,1,"POLR2H; GTF3C5; SNAPC2; "]
[null,3,29,0.530035335689046,3.52512216830671,0.0526146213242708,1,0.323842023501416,1,"GYS1; TRIP10; STX4; "]
[null,3,30,0.530035335689046,3.40765725100225,0.0572286142557724,1,0.33360879060725,1,"BAD; RPS6KB2; MLST8; "]
[null,3,31,0.530035335689046,3.29776827160844,0.062027218397302,1,0.353110581183276,1,"POLD1; POLD4; POLD2; "]
[null,3,31,0.530035335689046,3.29776827160844,0.062027218397302,1,0.353110581183276,1,"BAD; BBC3; E2F1; "]
[null,3,32,0.530035335689046,3.19474520782811,0.0670063397820453,1,0.377589779582607,1,"RPS6KA4; AP2A1; AP2S1; "]
[null,3,32,0.530035335689046,3.19474520782811,0.0670063397820453,1,0.377589779582607,1,"BAD; RPS6KB2; MLST8; "]
[null,3,33,0.530035335689046,3.09796407460096,0.0721616505162878,1,0.397246313733228,1,"POLD1; POLD4; POLD2; "]
[null,3,34,0.530035335689046,3.00687427528896,0.0774886152253854,1,0.420587691344594,1,"POLR2H; GTF3C5; SNAPC2; "]
[null,3,34,0.530035335689046,3.00687427528896,0.0774886152253854,1,0.420587691344594,1,"POLR2H; GTF3C5; SNAPC2; "]
[null,3,35,0.530035335689046,2.92098812061062,0.082982515868473,1,0.432546363964415,1,"MED15; TRIM28; MED25; "]
[null,3,37,0.530035335689046,2.76313953262842,0.0944514777136721,1,0.477409287352742,1,"HRAS; MAP2K2; MLST8; "]
[null,3,38,0.530035335689046,2.69044446468239,0.100416391829288,1,0.495545980980036,1,"BAD; HRAS; MAP2K2; "]
[null,3,39,0.530035335689046,2.62147639329858,0.106527987273237,1,0.509136626853179,1,"POLR2H; POLR2I; TAF10; "]
[null,3,39,0.530035335689046,2.62147639329858,0.106527987273237,1,0.509136626853179,1,"POLR2H; POLR2I; TAF10; "]
[null,3,39,0.530035335689046,2.62147639329858,0.106527987273237,1,0.509136626853179,1,"POLR2H; POLR2I; TAF10; "]
[null,3,39,0.530035335689046,2.62147639329858,0.106527987273237,1,0.509136626853179,1,"POLR2H; POLR2I; TAF10; "]
[null,3,39,0.530035335689046,2.62147639329858,0.106527987273237,1,0.509136626853179,1,"POLR2H; POLR2I; TAF10; "]
[null,3,39,0.530035335689046,2.62147639329858,0.106527987273237,1,0.509136626853179,1,"POLR2H; POLR2I; TAF10; "]
[null,3,48,0.530035335689046,2.13005194964753,0.167242595239519,1,0.667369973348127,1,"PLEC; CD151; ITGB4; "]
[null,3,50,0.530035335689046,2.04486690866982,0.181890701547908,1,0.710523864594637,1,"RELA; MAP2K2; NFKBIB; "]
[null,3,50,0.530035335689046,2.04486690866982,0.181890701547908,1,0.710523864594637,1,"RPS6KA4; HSPB1; KRT19; "]
[null,3,51,0.530035335689046,2.00477933939576,0.189339971082847,1,0.711486380442035,1,"HRAS; MAP2K2; MLST8; "]
[null,3,52,0.530035335689046,1.96623330326048,0.196865693511579,1,0.730619928795283,1,"BAD; HRAS; MAP2K2; "]
[null,3,53,0.530035335689046,1.92914156013163,0.204462678364543,1,0.74626640593448,1,"HRAS; MAP2K2; MLST8; "]
[null,3,54,0.530035335689046,1.89342333091238,0.212125804891659,1,0.756183894717778,1,"RELA; MAP2K2; NFKBIB; "]
[null,3,56,0.530035335689046,1.82581314234204,0.227630379529409,1,0.797814180635796,1,"HRAS; MAP2K2; MLST8; "]
[null,3,57,0.530035335689046,1.79378695145725,0.235461979807246,1,0.797814180635796,1,"HRAS; MAP2K2; AGRN; "]
[null,3,61,0.530035335689046,1.67618085727877,0.267206374674567,1,0.862741389279749,1,"RELA; HRAS; MAP2K2; "]
[null,3,64,0.530035335689046,1.59762215439115,0.291327322268782,1,0.916856553857224,1,"RRAS; RHOC; CFL1; "]
[null,3,64,0.530035335689046,1.59762215439115,0.291327322268782,1,0.916856553857224,1,"ADRM1; DVL1; AXIN1; "]
[null,3,64,0.530035335689046,1.59762215439115,0.291327322268782,1,0.916856553857224,1,"AURKAIP1; RELA; FZR1; "]
[null,3,66,0.530035335689046,1.54921669599421,0.307492982783976,1,0.954331239235353,1,"E2F1; SMARCA4; AATF; "]
[null,3,67,0.530035335689046,1.52609750936543,0.315589332337018,1,0.964043156151442,1,"RELA; HRAS; NFKBIB; "]
[null,3,69,0.530035335689046,1.48186920884767,0.331790152655432,1,0.984743727098328,1,"MED15; MED25; RELA; "]
[null,3,69,0.530035335689046,1.48186920884767,0.331790152655432,1,0.984743727098328,1,"BCAR1; RELA; HRAS; "]
[null,3,72,0.530035335689046,1.42013323292012,0.356058152332164,1,1,1,"BCAR1; ITGB4; BSG; "]
[null,3,82,0.530035335689046,1.24696737108374,0.43564173677416,1,1,1,"DVL1; AXIN1; JUP; "]
[null,3,83,0.530035335689046,1.23194547768435,0.443419228890928,1,1,1,"GNB2; TALDO1; TKT; "]
[null,3,84,0.530035335689046,1.21728120583952,0.451154421142668,1,1,1,"TRIM28; HRAS; MAD1L1; "]
[null,3,85,0.530035335689046,1.20296193509678,0.45884527074048,1,1,1,"RPL8; EEF1D; RPL28; "]
[null,3,92,0.530035335689046,1.11144217044427,0.511286779315751,1,1,1,"RPL8; EIF3B; RPL28; "]
[null,3,92,0.530035335689046,1.11144217044427,0.511286779315751,1,1,1,"POLR2H; GTF3C5; SNAPC2; "]
[null,3,95,0.530035335689046,1.07634769079652,0.532928597242718,1,1,1,"BAD; E2F1; FKBP8; "]
[null,3,98,0.530035335689046,1.04340163353309,0.554020328045264,1,1,1,"AURKAIP1; RELA; FZR1; "]
[null,3,101,0.530035335689046,1.01241257402809,0.574535100728995,1,1,1,"GIPC1; BAD; HRAS; "]
[null,3,102,0.530035335689046,1.0024879335612,0.581241281127716,1,1,1,"RPL8; EIF3B; RPL28; "]
[null,3,102,0.530035335689046,1.0024879335612,0.581241281127716,1,1,1,"RPL8; EIF3B; RPL28; "]
[null,3,103,0.530035335689046,0.992755985851642,0.587880252485326,1,1,1,"RPL8; EIF3B; RPL28; "]
[null,3,104,0.530035335689046,0.983211172988921,0.594451401976075,1,1,1,"RPL8; RNPS1; RPL28; "]
[null,3,104,0.530035335689046,0.983211172988921,0.594451401976075,1,1,1,"RPL8; RNPS1; RPL28; "]
[null,3,110,0.530035335689046,0.929586347628194,0.632426711685915,1,1,1,"RPL8; EIF3B; RPL28; "]
[null,3,110,0.530035335689046,0.929586347628194,0.632426711685915,1,1,1,"RPL8; EIF3B; RPL28; "]
[null,3,119,0.530035335689046,0.859287405281721,0.684623846042984,1,1,1,"KIF22; HMG20B; MAFK; "]
[null,3,127,0.530035335689046,0.805163326530019,0.726205644205501,1,1,1,"RELA; HRAS; MAP2K2; "]
[null,3,132,0.530035335689046,0.774667026002406,0.749941785397697,1,1,1,"RPL8; RPL28; RPN1; "]
[null,3,247,0.530035335689046,0.414006696500456,0.977859772553087,1,1,1,"SLC39A4; SLC16A3; SLC4A2; "]
[null,3,530,0.530035335689046,0.192946914402705,0.999983679914851,1,1,1,"GNA15; PLCB3; RHOC; "]
["ptr01100:",2,2,0.353356890459364,33.9746824261055,8.64826313931008E-4,1,0.0739193902117428,0.278191260408175,"TALDO1; TKT; "]
["ptr01100:",2,3,0.353356890459364,22.6874125171004,0.00254374438366584,1,0.0891367369122622,0.33546084619019,"HMGA1; BANF1; "]
["ptr01100:",2,4,0.353356890459364,17.0297036599681,0.00498824804547824,1,0.11469221159958,0.4316373662241,"BBC3; E2F1; "]
["ptr01100:",2,6,0.353356890459364,11.3625809777824,0.0119906115174986,1,0.137252672934057,0.516542330348533,"RUVBL2; NHP2; "]
["ptr01100:",2,6,0.353356890459364,11.3625809777824,0.0119906115174986,1,0.137252672934057,0.516542330348533,"OPLAH; GSS; "]
["ptr01100:",2,6,0.353356890459364,11.3625809777824,0.0119906115174986,1,0.137252672934057,0.516542330348533,"TALDO1; TKT; "]
["ptr01100:",2,7,0.353356890459364,9.74167070991043,0.0164618350354113,1,0.156904804794663,0.590501968223646,"AP2A1; AP2S1; "]
["ptr01100:",2,7,0.353356890459364,9.74167070991043,0.0164618350354113,1,0.156904804794663,0.590501968223646,"HRAS; MAP2K2; "]
["ptr01100:",2,7,0.353356890459364,9.74167070991043,0.0164618350354113,1,0.156904804794663,0.590501968223646,"HRAS; MAP2K2; "]
["ptr01100:",2,7,0.353356890459364,9.74167070991043,0.0164618350354113,1,0.156904804794663,0.590501968223646,"HMGA1; BANF1; "]
["ptr01100:",2,7,0.353356890459364,9.74167070991043,0.0164618350354113,1,0.156904804794663,0.590501968223646,"APRT; DGUOK; "]
["ptr01100:",2,8,0.353356890459364,8.52548210692536,0.0215252132588505,1,0.180422390531471,0.679009013521763,"ARHGAP39; GPC1; "]
["ptr01100:",2,8,0.353356890459364,8.52548210692536,0.0215252132588505,1,0.180422390531471,0.679009013521763,"STX4; AP2S1; "]
["ptr01100:",2,8,0.353356890459364,8.52548210692536,0.0215252132588505,1,0.180422390531471,0.679009013521763,"BAD; AATF; "]
["ptr01100:",2,8,0.353356890459364,8.52548210692536,0.0215252132588505,1,0.180422390531471,0.679009013521763,"ARHGDIA; RHOC; "]
["ptr01100:",2,8,0.353356890459364,8.52548210692536,0.0215252132588505,1,0.180422390531471,0.679009013521763,"ARHGDIA; RHOC; "]
["ptr01100:",2,8,0.353356890459364,8.52548210692536,0.0215252132588505,1,0.180422390531471,0.679009013521763,"MPG; NTHL1; "]
["ptr01100:",2,8,0.353356890459364,8.52548210692536,0.0215252132588505,1,0.180422390531471,0.679009013521763,"FPGS; SLC19A1; "]
["ptr01100:",2,9,0.353356890459364,7.57925767774386,0.0271421409373018,1,0.21155650038981,0.796180397625012,"AP2A1; AP2S1; "]
["ptr01100:",2,9,0.353356890459364,7.57925767774386,0.0271421409373018,1,0.21155650038981,0.796180397625012,"MPG; NTHL1; "]
["ptr01100:",2,9,0.353356890459364,7.57925767774386,0.0271421409373018,1,0.21155650038981,0.796180397625012,"OPLAH; GSS; "]
["ptr01100:",2,9,0.353356890459364,7.57925767774386,0.0271421409373018,1,0.21155650038981,0.796180397625012,"GPX1; GPX4; "]
["ptr01100:",2,9,0.353356890459364,7.57925767774386,0.0271421409373018,1,0.21155650038981,0.796180397625012,"NME2; NME3; "]
["ptr01100:",2,10,0.353356890459364,6.82208907856865,0.0332757654706049,1,0.238214492725188,0.896506177728001,"MPG; NTHL1; "]
["ptr01100:",2,11,0.353356890459364,6.20246245926178,0.0398909174733957,1,0.267836875358688,1,"HRAS; MAP2K2; "]
["ptr01100:",2,11,0.353356890459364,6.20246245926178,0.0398909174733957,1,0.267836875358688,1,"AP2A1; AP2S1; "]
["ptr01100:",2,11,0.353356890459364,6.20246245926178,0.0398909174733957,1,0.267836875358688,1,"NT5C; GPX1; "]
["ptr01100:",2,11,0.353356890459364,6.20246245926178,0.0398909174733957,1,0.267836875358688,1,"RELA; NFKBIB; "]
["ptr01100:",2,11,0.353356890459364,6.20246245926178,0.0398909174733957,1,0.267836875358688,1,"NME2; NME3; "]
["ptr01100:",2,12,0.353356890459364,5.68602095557636,0.046954043892365,1,0.303563353536685,1,"TUBGCP2; FZR1; "]
["ptr01100:",2,12,0.353356890459364,5.68602095557636,0.046954043892365,1,0.303563353536685,1,"MPG; NTHL1; "]
[null,2,13,0.353356890459364,5.24897092055897,0.0544331436114236,1,0.330161758341289,1,"IRAK1; RELA; "]
[null,2,13,0.353356890459364,5.24897092055897,0.0544331436114236,1,0.330161758341289,1,"HRAS; MAP2K2; "]
[null,2,13,0.353356890459364,5.24897092055897,0.0544331436114236,1,0.330161758341289,1,"RELA; NFKBIB; "]
[null,2,14,0.353356890459364,4.87431203971964,0.0622977054200459,1,0.353444124628015,1,"POLR2H; POLR2I; "]
[null,2,15,0.353356890459364,4.54957439550114,0.0705186482909776,1,0.389487103805797,1,"HRAS; MAP2K2; "]
[null,2,15,0.353356890459364,4.54957439550114,0.0705186482909776,1,0.389487103805797,1,"HRAS; MAP2K2; "]
[null,2,15,0.353356890459364,4.54957439550114,0.0705186482909776,1,0.389487103805797,1,"HRAS; MAP2K2; "]
[null,2,15,0.353356890459364,4.54957439550114,0.0705186482909776,1,0.389487103805797,1,"CDT1; E2F1; "]
[null,2,15,0.353356890459364,4.54957439550114,0.0705186482909776,1,0.389487103805797,1,"CDT1; E2F1; "]
[null,2,15,0.353356890459364,4.54957439550114,0.0705186482909776,1,0.389487103805797,1,"UBE2M; SMARCA4; "]
[null,2,16,0.353356890459364,4.26540360252793,0.0790682638562617,1,0.421360588218034,1,"HRAS; MAP2K2; "]
[null,2,16,0.353356890459364,4.26540360252793,0.0790682638562617,1,0.421360588218034,1,"IRAK1; RELA; "]
[null,2,16,0.353356890459364,4.26540360252793,0.0790682638562617,1,0.421360588218034,1,"HRAS; MAP2K2; "]
[null,2,16,0.353356890459364,4.26540360252793,0.0790682638562617,1,0.421360588218034,1,"HRAS; MAP2K2; "]
[null,2,16,0.353356890459364,4.26540360252793,0.0790682638562617,1,0.421360588218034,1,"GUK1; DTYMK; "]
[null,2,18,0.353356890459364,3.79173301923776,0.0970492126936538,1,0.484664930458127,1,"HRAS; MAP2K2; "]
[null,2,18,0.353356890459364,3.79173301923776,0.0970492126936538,1,0.484664930458127,1,"DVL1; AXIN1; "]
[null,2,19,0.353356890459364,3.59227310239201,0.106431504392876,1,0.509136626853179,1,"HRAS; MAP2K2; "]
[null,2,20,0.353356890459364,3.412749209219,0.116044284911768,1,0.528857560745435,1,"AP2A1; AP2S1; "]
[null,2,20,0.353356890459364,3.412749209219,0.116044284911768,1,0.528857560745435,1,"HRAS; MAP2K2; "]
[null,2,20,0.353356890459364,3.412749209219,0.116044284911768,1,0.528857560745435,1,"MVD; EBP; "]
[null,2,20,0.353356890459364,3.412749209219,0.116044284911768,1,0.528857560745435,1,"POLR2H; GTF3C5; "]
[null,2,21,0.353356890459364,3.25031469188349,0.125865918672854,1,0.564366538565375,1,"BAD; AATF; "]
[null,2,21,0.353356890459364,3.25031469188349,0.125865918672854,1,0.564366538565375,1,"HRAS; MAP2K2; "]
[null,2,21,0.353356890459364,3.25031469188349,0.125865918672854,1,0.564366538565375,1,"E2F1; MYBL2; "]
[null,2,21,0.353356890459364,3.25031469188349,0.125865918672854,1,0.564366538565375,1,"POLR2H; GTF3C5; "]
[null,2,22,0.353356890459364,3.10264023973067,0.13587584004334,1,0.595526992057256,1,"POLR2H; POLR2I; "]
[null,2,22,0.353356890459364,3.10264023973067,0.13587584004334,1,0.595526992057256,1,"POLR2H; POLR2I; "]
[null,2,22,0.353356890459364,3.10264023973067,0.13587584004334,1,0.595526992057256,1,"NT5C; TK1; "]
[null,2,22,0.353356890459364,3.10264023973067,0.13587584004334,1,0.595526992057256,1,"POLR2H; SNAPC2; "]
[null,2,23,0.353356890459364,2.96780146355811,0.146054509223127,1,0.621476840265754,1,"ARHGAP39; GPC1; "]
[null,2,23,0.353356890459364,2.96780146355811,0.146054509223127,1,0.621476840265754,1,"BCAR1; RHOC; "]
[null,2,24,0.353356890459364,2.84419457211462,0.156383369860575,1,0.6521186523186,1,"DGAT1; AGPAT2; "]
[null,2,25,0.353356890459364,2.73047227814763,0.166844808275171,1,0.667369973348127,1,"TRAF2; IRF3; "]
[null,2,25,0.353356890459364,2.73047227814763,0.166844808275171,1,0.667369973348127,1,"MVD; EBP; "]
[null,2,26,0.353356890459364,2.62549448967598,0.177422114173447,1,0.697971901984221,1,"POLR2H; POLR2I; "]
[null,2,26,0.353356890459364,2.62549448967598,0.177422114173447,1,0.697971901984221,1,"POLR2H; POLR2I; "]
[null,2,26,0.353356890459364,2.62549448967598,0.177422114173447,1,0.697971901984221,1,"GPAA1; DPM2; "]
[null,2,26,0.353356890459364,2.62549448967598,0.177422114173447,1,0.697971901984221,1,"HRAS; MAP2K2; "]
[null,2,27,0.353356890459364,2.52828995470093,0.18809944291615,1,0.711486380442035,1,"AP2A1; AP2S1; "]
[null,2,27,0.353356890459364,2.52828995470093,0.18809944291615,1,0.711486380442035,1,"RRAS; RHOC; "]
[null,2,28,0.353356890459364,2.4380261219733,0.198861779180491,1,0.730619928795283,1,"HRAS; RRAS; "]
[null,2,28,0.353356890459364,2.4380261219733,0.198861779180491,1,0.730619928795283,1,"CDT1; E2F1; "]
[null,2,28,0.353356890459364,2.4380261219733,0.198861779180491,1,0.730619928795283,1,"POLR2H; POLR2I; "]
[null,2,28,0.353356890459364,2.4380261219733,0.198861779180491,1,0.730619928795283,1,"HRAS; MAP2K2; "]
[null,2,28,0.353356890459364,2.4380261219733,0.198861779180491,1,0.730619928795283,1,"GNA15; PLCB3; "]
[null,2,29,0.353356890459364,2.35398523531445,0.209694901983121,1,0.756183894717778,1,"BCAR1; RELA; "]
[null,2,30,0.353356890459364,2.27554520747991,0.220585351103676,1,0.781181243399004,1,"HRAS; MAP2K2; "]
[null,2,30,0.353356890459364,2.27554520747991,0.220585351103676,1,0.781181243399004,1,"ALG3; DPM2; "]
[null,2,31,0.353356890459364,2.20216419466211,0.231520394725758,1,0.797814180635796,1,"HMGA1; BANF1; "]
[null,2,31,0.353356890459364,2.20216419466211,0.231520394725758,1,0.797814180635796,1,"E2F1; CKS1B; "]
[null,2,31,0.353356890459364,2.20216419466211,0.231520394725758,1,0.797814180635796,1,"E2F1; CKS1B; "]
[null,2,31,0.353356890459364,2.20216419466211,0.231520394725758,1,0.797814180635796,1,"BSG; MDH2; "]
[null,2,31,0.353356890459364,2.20216419466211,0.231520394725758,1,0.797814180635796,1,"PAFAH1B3; NUDC; "]
[null,2,32,0.353356890459364,2.13336806237026,0.242487998391828,1,0.817111073368825,1,"BCAR1; MAP2K2; "]
[null,2,33,0.353356890459364,2.06874012955081,0.253476795032699,1,0.846478920240556,1,"BCAR1; MDK; "]
[null,2,33,0.353356890459364,2.06874012955081,0.253476795032699,1,0.846478920240556,1,"BAD; STUB1; "]
[null,2,34,0.353356890459364,2.00791272203682,0.264476056273062,1,0.856594294880519,1,"CPSF1; RNPS1; "]
[null,2,34,0.353356890459364,2.00791272203682,0.264476056273062,1,0.856594294880519,1,"CPSF1; RNPS1; "]
[null,2,34,0.353356890459364,2.00791272203682,0.264476056273062,1,0.856594294880519,1,"HRAS; RRAS; "]
[null,2,34,0.353356890459364,2.00791272203682,0.264476056273062,1,0.856594294880519,1,"HRAS; RRAS; "]
[null,2,34,0.353356890459364,2.00791272203682,0.264476056273062,1,0.856594294880519,1,"HMGA1; BANF1; "]
[null,2,34,0.353356890459364,2.00791272203682,0.264476056273062,1,0.856594294880519,1,"GNA15; PLCB3; "]
[null,2,35,0.353356890459364,1.9505601735639,0.275475664781343,1,0.885343755019808,1,"RELA; TRAF2; "]
[null,2,35,0.353356890459364,1.9505601735639,0.275475664781343,1,0.885343755019808,1,"HRAS; ITGB4; "]
[null,2,38,0.353356890459364,1.79660909435602,0.308384015556268,1,0.954331239235353,1,"RANGAP1; RFXANK; "]
[null,2,38,0.353356890459364,1.79660909435602,0.308384015556268,1,0.954331239235353,1,"GNA15; PLCB3; "]
[null,2,39,0.353356890459364,1.75055400349839,0.319295152216759,1,0.964043156151442,1,"PLEC; BCAP31; "]
[null,2,39,0.353356890459364,1.75055400349839,0.319295152216759,1,0.964043156151442,1,"TNIP2; IRAK1; "]
[null,2,40,0.353356890459364,1.70680109163889,0.330164320562603,1,0.983418011961469,1,"HRAS; RRAS; "]
[null,2,42,0.353356890459364,1.6255441960598,0.351749300757311,1,1,1,"POLR2H; POLR2I; "]
[null,2,42,0.353356890459364,1.6255441960598,0.351749300757311,1,1,1,"PLK1; CKS1B; "]
[null,2,43,0.353356890459364,1.58774963209654,0.362452480407329,1,1,1,"CPSF1; RNPS1; "]
[null,2,43,0.353356890459364,1.58774963209654,0.362452480407329,1,1,1,"CPSF1; RNPS1; "]
[null,2,43,0.353356890459364,1.58774963209654,0.362452480407329,1,1,1,"CPSF1; RNPS1; "]
[null,2,45,0.353356890459364,1.51719865977499,0.383651712974115,1,1,1,"ARFGAP1; YIF1A; "]
[null,2,46,0.353356890459364,1.48422324878227,0.394137515720453,1,1,1,"DVL1; AXIN1; "]
[null,2,47,0.353356890459364,1.45265074827637,0.404541208351738,1,1,1,"H2AFX; ACD; "]
[null,2,48,0.353356890459364,1.42239349461512,0.414858539367667,1,1,1,"PLEC; BCAP31; "]
[null,2,48,0.353356890459364,1.42239349461512,0.414858539367667,1,1,1,"H2AFX; XRCC3; "]
[null,2,50,0.353356890459364,1.3655091317031,0.435218697490428,1,1,1,"TNIP2; RELA; "]
[null,2,52,0.353356890459364,1.31299964769222,0.455190118700594,1,1,1,"LMNB2; TRAF2; "]
[null,2,52,0.353356890459364,1.31299964769222,0.455190118700594,1,1,1,"BCAR1; CAPN1; "]
[null,2,53,0.353356890459364,1.28823074281215,0.465022567305459,1,1,1,"PPP1CA; PLCB3; "]
[null,2,55,0.353356890459364,1.24139450420782,0.484368208847828,1,1,1,"CPSF1; RNPS1; "]
[null,2,57,0.353356890459364,1.19784444266746,0.503273927793011,1,1,1,"IRAK1; RELA; "]
[null,2,58,0.353356890459364,1.17719551243703,0.512557281119053,1,1,1,"RELA; TRAF2; "]
[null,2,60,0.353356890459364,1.13796220090772,0.530777640711958,1,1,1,"HRAS; RRAS; "]
[null,2,63,0.353356890459364,1.08378212468612,0.557225664633351,1,1,1,"ARFGAP1; YIF1A; "]
[null,2,63,0.353356890459364,1.08378212468612,0.557225664633351,1,1,1,"BAD; HRAS; "]
[null,2,64,0.353356890459364,1.06685067452698,0.565803030497378,1,1,1,"BCAR1; RELA; "]
[null,2,64,0.353356890459364,1.06685067452698,0.565803030497378,1,1,1,"MPG; UBE2M; "]
[null,2,65,0.353356890459364,1.05044011192851,0.574260131512175,1,1,1,"HRAS; MAP2K2; "]
[null,2,67,0.353356890459364,1.01908837004137,0.590812213287164,1,1,1,"RELA; E2F1; "]
[null,2,68,0.353356890459364,1.00410397995107,0.598906837524584,1,1,1,"E2F1; ACD; "]
[null,2,72,0.353356890459364,0.948328172149314,0.630076879165711,1,1,1,"H2AFX; ACD; "]
[null,2,76,0.353356890459364,0.898422729594424,0.659328053594864,1,1,1,"GNB2; KCNN4; "]
[null,2,77,0.353356890459364,0.886756417042879,0.666344858438883,1,1,1,"PAK4; HRAS; "]
[null,2,80,0.353356890459364,0.853507207554957,0.686696412165186,1,1,1,"ALDOA; NAA10; "]
[null,2,80,0.353356890459364,0.853507207554957,0.686696412165186,1,1,1,"RELA; SMARCA4; "]
[null,2,82,0.353356890459364,0.832692496969542,0.699690352198276,1,1,1,"RPL8; RPL28; "]
[null,2,82,0.353356890459364,0.832692496969542,0.699690352198276,1,1,1,"RPL8; RPL28; "]
[null,2,82,0.353356890459364,0.832692496969542,0.699690352198276,1,1,1,"RPL8; RPL28; "]
[null,2,85,0.353356890459364,0.803306807157654,0.718339977724147,1,1,1,"RELA; SMARCA4; "]
[null,2,87,0.353356890459364,0.784842106384003,0.730224649510833,1,1,1,"RPL8; RPL28; "]
[null,2,94,0.353356890459364,0.726402634575812,0.768513375022702,1,1,1,"SLC39A4; SLC16A3; "]
[null,2,98,0.353356890459364,0.696756572558638,0.788201855975474,1,1,1,"RPL8; RPL28; "]
[null,2,108,0.353356890459364,0.632248048111028,0.831094339831722,1,1,1,"RPL8; RPL28; "]
[null,2,108,0.353356890459364,0.632248048111028,0.831094339831722,1,1,1,"ZMIZ2; PKN1; "]
[null,2,120,0.353356890459364,0.569028511594635,0.872133799291038,1,1,1,"GNA15; PLCB3; "]
[null,2,133,0.353356890459364,0.513413364983626,0.906098943277737,1,1,1,"RELA; HRAS; "]
[null,2,135,0.353356890459364,0.505807804432799,0.910508010212971,1,1,1,"RUVBL2; SMARCA4; "]
[null,2,274,0.353356890459364,0.249221238920011,0.997524072489879,1,1,1,"NMB; DRD4; "]
[null,2,336,0.353356890459364,0.203235355127741,0.99954551531698,1,1,1,"NMB; DRD4; "]
["ptr01100:",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.219172052607028,0.824841078725648,"PPIA; "]
["ptr01100:",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.219172052607028,0.824841078725648,"PPIA; "]
["ptr01100:",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.219172052607028,0.824841078725648,"PPIA; "]
["ptr01100:",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.219172052607028,0.824841078725648,"PPIA; "]
["ptr01100:",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.219172052607028,0.824841078725648,"APRT; "]
["ptr01100:",1,1,0.176678445229682,33.9746824261055,0.0294331773285218,1,0.219172052607028,0.824841078725648,"COMT; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"MAP2K2; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"COMT; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"COMT; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"MAD1L1; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"PPIA; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"NOSIP; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"MAD1L1; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"DOHH; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"NAPRT; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"DOHH; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"TSTA3; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"GSS; "]
[null,1,2,0.176678445229682,17.0718553484411,0.0580015283429871,1,0.33360879060725,1,"MDK; "]
[null,1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.437303795393155,1,"COMT; "]
[null,1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.437303795393155,1,"E2F1; "]
[null,1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.437303795393155,1,"MPG; "]
[null,1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.437303795393155,1,"MPG; "]
[null,1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.437303795393155,1,"MPG; "]
[null,1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.437303795393155,1,"DPM2; "]
[null,1,3,0.176678445229682,11.4001426080952,0.0857304203198812,1,0.437303795393155,1,"ACOT8; "]
[null,1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.521919413559777,1,"RPS6KB2; "]
[null,1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.521919413559777,1,"H2AFX; "]
[null,1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.521919413559777,1,"H2AFX; "]
[null,1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.521919413559777,1,"SLC16A3; "]
[null,1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.521919413559777,1,"E2F1; "]
[null,1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.521919413559777,1,"BLVRB; "]
[null,1,4,0.176678445229682,8.5572142768994,0.112644477746714,1,0.521919413559777,1,"PGLS; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"HRAS; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"ARHGDIA; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"PLCB3; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"DRD4; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"NTHL1; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"NTHL1; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"NTHL1; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"FPGS; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"TK1; "]
[null,1,5,0.176678445229682,6.84918747512307,0.138767604010056,1,0.595526992057256,1,"MDH2; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"MAP2K2; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"COMT; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"PLCB3; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"MLST8; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"HRAS; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"ACOT8; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"ECI1; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"H2AFX; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"H2AFX; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"COMT; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"COASY; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"IRF3; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"RELA; "]
[null,1,6,0.176678445229682,5.7095556157016,0.164123002504641,1,0.659655826934316,1,"GYS1; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"AP2S1; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"ARHGDIA; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"AXIN1; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"TK1; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"GPAA1; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"BAD; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"TRAF2; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"HRAS; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"COASY; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"SMPD4; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"COMT; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"ALDOA; "]
[null,1,7,0.176678445229682,4.89506836667141,0.188733197083219,1,0.711486380442035,1,"COMT; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"RRAS; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"GPC1; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"GNA15; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"PLCB3; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"ARHGDIA; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"E2F1; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"ACOT8; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"H2AFX; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"NAPRT; "]
[null,1,8,0.176678445229682,4.28394872039533,0.212620051932037,1,0.756183894717778,1,"IRAK1; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"GPC1; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"KCNN4; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"HRAS; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"RELA; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"BAD; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"MGAT4B; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"COASY; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"SLC4A2; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"TRAF2; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"TRAF2; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"IRF3; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"PRKCSH; "]
[null,1,9,0.176678445229682,3.80848271369219,0.235804790799429,1,0.797814180635796,1,"PTGES2; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"BCAR1; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"GNA15; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"BSG; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"NT5C; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"ARFGAP1; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"ARFGAP1; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"SLC39A4; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"IRAK1; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"IRAK1; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"IRF3; "]
[null,1,10,0.176678445229682,3.42801491012653,0.258308015828803,1,0.846478920240556,1,"MVD; "]
[null,1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,0.888383540748344,1,"MLST8; "]
[null,1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,0.888383540748344,1,"MLST8; "]
[null,1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,0.888383540748344,1,"E2F1; "]
[null,1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,0.888383540748344,1,"PLCB3; "]
[null,1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,0.888383540748344,1,"PLEC; "]
[null,1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,0.888383540748344,1,"ITGB4; "]
[null,1,11,0.176678445229682,3.11666024072358,0.280149725679634,1,0.888383540748344,1,"PKN1; "]
[null,1,12,0.176678445229682,2.85715480852345,0.301349333118106,1,0.937781133658585,1,"MGAT4B; "]
[null,1,12,0.176678445229682,2.85715480852345,0.301349333118106,1,0.937781133658585,1,"PRKCSH; "]
[null,1,12,0.176678445229682,2.85715480852345,0.301349333118106,1,0.937781133658585,1,"SLC16A3; "]
[null,1,12,0.176678445229682,2.85715480852345,0.301349333118106,1,0.937781133658585,1,"PPP1CA; "]
[null,1,12,0.176678445229682,2.85715480852345,0.301349333118106,1,0.937781133658585,1,"POLR2H; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"IRAK1; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"PRKCSH; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"LSM4; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"TRAF2; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"TRAF2; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"TSTA3; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"MVD; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"EBP; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"EBP; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"EBP; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"MDH2; "]
[null,1,13,0.176678445229682,2.63754260187291,0.32192568224002,1,0.964043156151442,1,"PNKP; "]
[null,1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,0.997000532372441,1,"RRAS; "]
[null,1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,0.997000532372441,1,"CPSF1; "]
[null,1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,0.997000532372441,1,"PKMYT1; "]
[null,1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,0.997000532372441,1,"PFDN2; "]
[null,1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,0.997000532372441,1,"DOHH; "]
[null,1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,0.997000532372441,1,"ECI1; "]
[null,1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,0.997000532372441,1,"PHKG2; "]
[null,1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,0.997000532372441,1,"PNPLA2; "]
[null,1,14,0.176678445229682,2.44928117418748,0.341897065058175,1,0.997000532372441,1,"RELA; "]
[null,1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"CFL1; "]
[null,1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"GNB2; "]
[null,1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"GNB2; "]
[null,1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"GNB2; "]
[null,1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"ACOT8; "]
[null,1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"PFDN2; "]
[null,1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"AGPAT2; "]
[null,1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"RANGAP1; "]
[null,1,15,0.176678445229682,2.28610454699311,0.361281237687724,1,1,1,"GNA15; "]
[null,1,16,0.176678445229682,2.14331225798667,0.380095435962882,1,1,1,"GNA15; "]
[null,1,16,0.176678445229682,2.14331225798667,0.380095435962882,1,1,1,"DRAP1; "]
[null,1,16,0.176678445229682,2.14331225798667,0.380095435962882,1,1,1,"DPM2; "]
[null,1,16,0.176678445229682,2.14331225798667,0.380095435962882,1,1,1,"PFDN2; "]
[null,1,16,0.176678445229682,2.14331225798667,0.380095435962882,1,1,1,"AGPAT2; "]
[null,1,17,0.176678445229682,2.01730918579463,0.39835639063409,1,1,1,"GNA15; "]
[null,1,17,0.176678445229682,2.01730918579463,0.39835639063409,1,1,1,"HRAS; "]
[null,1,17,0.176678445229682,2.01730918579463,0.39835639063409,1,1,1,"DPM2; "]
[null,1,17,0.176678445229682,2.01730918579463,0.39835639063409,1,1,1,"SLC39A4; "]
[null,1,17,0.176678445229682,2.01730918579463,0.39835639063409,1,1,1,"MLST8; "]
[null,1,17,0.176678445229682,2.01730918579463,0.39835639063409,1,1,1,"POLR2H; "]
[null,1,17,0.176678445229682,2.01730918579463,0.39835639063409,1,1,1,"RELA; "]
[null,1,18,0.176678445229682,1.90529868130853,0.416080342275909,1,1,1,"HRAS; "]
[null,1,18,0.176678445229682,1.90529868130853,0.416080342275909,1,1,1,"PPP1CA; "]
[null,1,18,0.176678445229682,1.90529868130853,0.416080342275909,1,1,1,"NOSIP; "]
[null,1,18,0.176678445229682,1.90529868130853,0.416080342275909,1,1,1,"NOSIP; "]
[null,1,18,0.176678445229682,1.90529868130853,0.416080342275909,1,1,1,"SLC25A1; "]
[null,1,19,0.176678445229682,1.80507255393827,0.433283055472618,1,1,1,"ACOT8; "]
[null,1,19,0.176678445229682,1.80507255393827,0.433283055472618,1,1,1,"MDH2; "]
[null,1,19,0.176678445229682,1.80507255393827,0.433283055472618,1,1,1,"ECI1; "]
[null,1,19,0.176678445229682,1.80507255393827,0.433283055472618,1,1,1,"GSTP1; "]
[null,1,19,0.176678445229682,1.80507255393827,0.433283055472618,1,1,1,"BCAR1; "]
[null,1,20,0.176678445229682,1.71486403050308,0.4499798329091,1,1,1,"BCAR1; "]
[null,1,20,0.176678445229682,1.71486403050308,0.4499798329091,1,1,1,"ACOT8; "]
[null,1,20,0.176678445229682,1.71486403050308,0.4499798329091,1,1,1,"POLR2H; "]
[null,1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"KIF22; "]
[null,1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"AP2S1; "]
[null,1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"AP2S1; "]
[null,1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"ACD; "]
[null,1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"RHOC; "]
[null,1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"POLR2H; "]
[null,1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"HSPB1; "]
[null,1,21,0.176678445229682,1.6332427058718,0.466185528607616,1,1,1,"JUP; "]
[null,1,22,0.176678445229682,1.55903813041193,0.481914561394994,1,1,1,"RHOC; "]
[null,1,22,0.176678445229682,1.55903813041193,0.481914561394994,1,1,1,"MAP2K2; "]
[null,1,23,0.176678445229682,1.49128332248442,0.497180927410287,1,1,1,"CPSF1; "]
[null,1,23,0.176678445229682,1.49128332248442,0.497180927410287,1,1,1,"CPSF1; "]
[null,1,23,0.176678445229682,1.49128332248442,0.497180927410287,1,1,1,"AGRN; "]
[null,1,23,0.176678445229682,1.49128332248442,0.497180927410287,1,1,1,"GNB2; "]
[null,1,24,0.176678445229682,1.42917239693322,0.511998212519025,1,1,1,"VARS; "]
[null,1,24,0.176678445229682,1.42917239693322,0.511998212519025,1,1,1,"POLR2H; "]
[null,1,25,0.176678445229682,1.3720283586712,0.526379604377282,1,1,1,"SLC39A4; "]
[null,1,25,0.176678445229682,1.3720283586712,0.526379604377282,1,1,1,"BAD; "]
[null,1,26,0.176678445229682,1.31927832565808,0.540337903982013,1,1,1,"GNA15; "]
[null,1,26,0.176678445229682,1.31927832565808,0.540337903982013,1,1,1,"NR1H2; "]
[null,1,27,0.176678445229682,1.27043425584475,0.553885537089529,1,1,1,"MLST8; "]
[null,1,27,0.176678445229682,1.27043425584475,0.553885537089529,1,1,1,"ACOT8; "]
[null,1,27,0.176678445229682,1.27043425584475,0.553885537089529,1,1,1,"JUP; "]
[null,1,27,0.176678445229682,1.27043425584475,0.553885537089529,1,1,1,"ATP6V0C; "]
[null,1,28,0.176678445229682,1.2250778025836,0.567034565171691,1,1,1,"GNB2; "]
[null,1,28,0.176678445229682,1.2250778025836,0.567034565171691,1,1,1,"GNB2; "]
[null,1,28,0.176678445229682,1.2250778025836,0.567034565171691,1,1,1,"ATP6V0C; "]
[null,1,28,0.176678445229682,1.2250778025836,0.567034565171691,1,1,1,"MLST8; "]
[null,1,28,0.176678445229682,1.2250778025836,0.567034565171691,1,1,1,"MGAT4B; "]
[null,1,28,0.176678445229682,1.2250778025836,0.567034565171691,1,1,1,"PFDN2; "]
[null,1,28,0.176678445229682,1.2250778025836,0.567034565171691,1,1,1,"IRF3; "]
[null,1,29,0.176678445229682,1.18284830232219,0.579796695995637,1,1,1,"BCAR1; "]
[null,1,29,0.176678445229682,1.18284830232219,0.579796695995637,1,1,1,"HRAS; "]
[null,1,29,0.176678445229682,1.18284830232219,0.579796695995637,1,1,1,"MAP3K11; "]
[null,1,29,0.176678445229682,1.18284830232219,0.579796695995637,1,1,1,"GNA15; "]
[null,1,30,0.176678445229682,1.14343316395757,0.592183294087811,1,1,1,"CDT1; "]
[null,1,30,0.176678445229682,1.14343316395757,0.592183294087811,1,1,1,"MAP2K2; "]
[null,1,32,0.176678445229682,1.07199091691242,0.61587369368554,1,1,1,"RANGAP1; "]
[null,1,32,0.176678445229682,1.07199091691242,0.61587369368554,1,1,1,"RELA; "]
[null,1,33,0.176678445229682,1.03951618450065,0.627198596777642,1,1,1,"RANGAP1; "]
[null,1,33,0.176678445229682,1.03951618450065,0.627198596777642,1,1,1,"STX4; "]
[null,1,33,0.176678445229682,1.03951618450065,0.627198596777642,1,1,1,"STX4; "]
[null,1,33,0.176678445229682,1.03951618450065,0.627198596777642,1,1,1,"GNB2; "]
[null,1,34,0.176678445229682,1.00895116878467,0.638190188919918,1,1,1,"HRAS; "]
[null,1,34,0.176678445229682,1.00895116878467,0.638190188919918,1,1,1,"HRAS; "]
[null,1,35,0.176678445229682,0.980132226517184,0.648858263156739,1,1,1,"CPSF1; "]
[null,1,35,0.176678445229682,0.980132226517184,0.648858263156739,1,1,1,"RELA; "]
[null,1,36,0.176678445229682,0.952913891984632,0.659212325335024,1,1,1,"GNB2; "]
[null,1,36,0.176678445229682,0.952913891984632,0.659212325335024,1,1,1,"CPSF1; "]
[null,1,36,0.176678445229682,0.952913891984632,0.659212325335024,1,1,1,"DRD4; "]
[null,1,36,0.176678445229682,0.952913891984632,0.659212325335024,1,1,1,"MLST8; "]
[null,1,37,0.176678445229682,0.927166421247409,0.669261602400543,1,1,1,"ATP6V0C; "]
[null,1,38,0.176678445229682,0.90277372402964,0.679015050694865,1,1,1,"MLST8; "]
[null,1,39,0.176678445229682,0.879631613698195,0.688481363805299,1,1,1,"PLCB3; "]
[null,1,39,0.176678445229682,0.879631613698195,0.688481363805299,1,1,1,"SIRT7; "]
[null,1,40,0.176678445229682,0.857646319679245,0.697668980318492,1,1,1,"PLCB3; "]
[null,1,42,0.176678445229682,0.816815740308655,0.71524064698807,1,1,1,"VARS; "]
[null,1,42,0.176678445229682,0.816815740308655,0.71524064698807,1,1,1,"H2AFX; "]
[null,1,42,0.176678445229682,0.816815740308655,0.71524064698807,1,1,1,"HRAS; "]
[null,1,43,0.176678445229682,0.797824441998758,0.723640365293076,1,1,1,"RELA; "]
[null,1,43,0.176678445229682,0.797824441998758,0.723640365293076,1,1,1,"BCAR1; "]
[null,1,45,0.176678445229682,0.762373455906834,0.739705032834691,1,1,1,"JUP; "]
[null,1,46,0.176678445229682,0.745803722024921,0.74738431098951,1,1,1,"PPP1CA; "]
[null,1,47,0.176678445229682,0.729938933213499,0.754837421927395,1,1,1,"RELA; "]
[null,1,47,0.176678445229682,0.729938933213499,0.754837421927395,1,1,1,"EIF3B; "]
[null,1,47,0.176678445229682,0.729938933213499,0.754837421927395,1,1,1,"IRF3; "]
[null,1,47,0.176678445229682,0.729938933213499,0.754837421927395,1,1,1,"NR1H2; "]
[null,1,48,0.176678445229682,0.714735039582724,0.762071015193526,1,1,1,"POLR2H; "]
[null,1,48,0.176678445229682,0.714735039582724,0.762071015193526,1,1,1,"PAK4; "]
[null,1,49,0.176678445229682,0.700151586418417,0.769091545120955,1,1,1,"E2F1; "]
[null,1,49,0.176678445229682,0.700151586418417,0.769091545120955,1,1,1,"PLK1; "]
[null,1,51,0.176678445229682,0.672700044116185,0.782518290931865,1,1,1,"RNPS1; "]
[null,1,52,0.176678445229682,0.659765992123949,0.788936490414516,1,1,1,"MLST8; "]
[null,1,54,0.176678445229682,0.635334738944021,0.801211193672853,1,1,1,"EIF3B; "]
[null,1,54,0.176678445229682,0.635334738944021,0.801211193672853,1,1,1,"EIF3B; "]
[null,1,54,0.176678445229682,0.635334738944021,0.801211193672853,1,1,1,"POLR2H; "]
[null,1,54,0.176678445229682,0.635334738944021,0.801211193672853,1,1,1,"GNA15; "]
[null,1,54,0.176678445229682,0.635334738944021,0.801211193672853,1,1,1,"HRAS; "]
[null,1,55,0.176678445229682,0.623785298134277,0.807078656382711,1,1,1,"EIF3B; "]
[null,1,56,0.176678445229682,0.612648263709455,0.812773231631306,1,1,1,"POLR2H; "]
[null,1,57,0.176678445229682,0.601901933877681,0.818300004914825,1,1,1,"RELA; "]
[null,1,59,0.176678445229682,0.581501936118736,0.828869745085639,1,1,1,"RUVBL2; "]
[null,1,62,0.176678445229682,0.553369283186044,0.843584621132455,1,1,1,"HMGA1; "]
[null,1,63,0.176678445229682,0.5445870377776,0.848203313957939,1,1,1,"ITGB4; "]
[null,1,66,0.176678445229682,0.519836831546229,0.861258408659174,1,1,1,"ALDOA; "]
[null,1,66,0.176678445229682,0.519836831546229,0.861258408659174,1,1,1,"RELA; "]
[null,1,77,0.176678445229682,0.445584070255377,0.900241567204897,1,1,1,"IRF3; "]
[null,1,92,0.176678445229682,0.372942389418178,0.9363989283158,1,1,1,"HMGA1; "]
[null,1,94,0.176678445229682,0.365008289015707,0.940105355500673,1,1,1,"SLC4A2; "]
[null,1,94,0.176678445229682,0.365008289015707,0.940105355500673,1,1,1,"E2F1; "]
[null,1,94,0.176678445229682,0.365008289015707,0.940105355500673,1,1,1,"E2F1; "]
[null,1,98,0.176678445229682,0.350111511584191,0.946883823336413,1,1,1,"IRF3; "]
[null,1,111,0.176678445229682,0.309111154403807,0.964055995111597,1,1,1,"RELA; "]
[null,1,125,0.176678445229682,0.274493474524971,0.976403424967748,1,1,1,"FZR1; "]
[null,1,167,0.176678445229682,0.205463321060814,0.993336543585579,1,1,1,"NMB; "]

{"sheet":"TCGA-HSF1-COX model","index":4,"n_rows":17,"n_cols":6,"rows_kept":17,"merged":[[0,0,7,0],[9,0,16,0]]}
["unilateral","id","HR","HR.95L","HR.95H","pvalue"]
[null,"age",1.02793548278095,1.0051388607862,1.05124913380984,0.0160436677994907]
[null,"gender",0.781359797326071,0.508894424271384,1.19970489704532,0.259437641589692]
[null,"grade",1.33125226930404,0.981451346142811,1.80572639845286,0.0658289034769982]
[null,"stage",1.29386214175443,0.8620902639924,1.94188394393017,0.213634442698059]
[null,"T",1.62405297150057,0.976667132397102,2.70055985990467,0.0616269867094064]
[null,"N",2.25796093773067,1.30802104281011,3.8977871375558,0.00345629832655746]
[null,"HSF1",1.20780617521698,0.772223295816767,1.88908540417617,0.408052378766239]
[]
["multifactorial ","id","HR","HR.95L","HR.95H","pvalue"]
[null,"age",1.02273240562022,1.00045254881109,1.04550842990877,0.0454759115626036]
[null,"gender",0.785056234720292,0.505958487961497,1.2181103911436,0.280277671620837]
[null,"grade",1.19169569885948,0.878085721572047,1.61731207306014,0.260351487708219]
[null,"stage",0.993804252544655,0.516694591997229,1.91147131724022,0.985141695367027]
[null,"T",1.34506872934328,0.683067126130239,2.64865606533697,0.391190201927374]
[null,"N",1.93562787978023,1.09768971903302,3.41321889420905,0.0224875505827037]
[null,"HSF1",1.19309886948705,0.757558343350848,1.87904327747864,0.446148769239141]

{"sheet":"TCGA-HSF1-Clinical feature","index":5,"n_rows":2,"n_cols":67,"rows_kept":2}
["Age",{"$nulls":10},"Gender",{"$nulls":10},"Grade",{"$nulls":10},"Stage",{"$nulls":10},"（T）Tumor size",{"$nulls":10},"（N）Lymph node metastasis",{"$nulls":10},"（M）Distance metastasis"]
[{"$nulls":66},"The data were incomplete and unanalyzed"]

{"sheet":"KRAS based-HSF1 expression","index":6,"n_rows":314,"n_cols":252,"rows_kept":314,"merged":[[1,0,132,0],[135,6,135,10],[136,0,313,0]]}
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P_Polyphen2_HDIV_score","ClinVar_HGMD_ID","dbNSFP_genename","t_ref_count_KRAS","dbNSFP_SIFT_converted_rankscore","hgsc","ccds_id","dbNSFP_RadialSVM_pred","ClinVar_rs","dbNSFP_SIFT_score","DrugBank","dbNSFP_phyloP100way_vertebrate","Genome_Change","OREGANNO_Values","validation_normal_ref_count_rna","SCNA_q_hat","dbNSFP_Interpro_domain","CGC_CancerSyndrome","external_id_capture","CGC_Chr","dbNSFP_hg18_pos1coor","validation_tumor_ref_count_targeted","Annotation_Transcript","build","CGC_Name","dbNSFP_Polyphen2_HVAR_rankscore","dbNSFP_Reliability_index"]
["KRAS mutant information (KRASMUT)","KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-8127-01","TCGA-IB-8127-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",69,48,24,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,4,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,69,0.78595,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.345273,15813,".","SO:0001583",420,0.8502,0,1,1,0.80357,null,3845,111,5.68,".",1,".",46,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,3.33,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.551105,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.35,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",1,"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,35,0,"M","D",".",0.77884,24,48,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,24,6,"Small GTP-binding protein domain (1);",null,"TCGA-IB-8127-01A-11D-2396-08",12,25289551,246,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-IB-7652-01","TCGA-IB-7652-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",85,8,45,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,84,0.78246,null,"12p12.1","GRCh37",null,0.62,0.62,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.241829,5144,".","SO:0001583",403,0.8502,0,1,1,0.80357,null,3845,69,5.68,".",1,".",31,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-5.897826,1.99,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.42,"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.28,0.429793,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.36,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,0.989988,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.671172,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.9788113,"d":"9.79E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999997,"d":"1.00E+00"},45,0,"M","D",".",0.77884,45,8,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,45,4,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7652-01A-11D-2154-08",12,25289552,457,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-Q3-A5QY-01","TCGA-Q3-A5QY-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",111,1,22,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,27.2,"RASK_HUMAN",1,{"v":0.56,"d":"5.60E-01"},"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,110,0.78707,0,"12p12.1",null,null,0.28,0.28,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.995946,15813,".","SO:0001583",803,0.8502,0,null,1,0.80357,null,3845,2,5.68,".",1,".",0,{"v":0.9994317,"d":"9.99E-01"},25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-3.209571,2.02,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.12,"d":"1.20E-01"},"D;D","p.G12V","-",12,133,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.03,0.082985,null,null,".",0.90707,0,0.9065,0,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.09,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,22,"Familial Cancer Database",0,0.18,0,{"v":0.4932735,"d":"4.93E-01"},0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,null,0.346071,0.90789,"NP_203524.1",0.89,"missense",0.80722,"0.969;0.978",{"v":1.341435E-3,"d":"1.34E-03"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.6835965,"d":"6.84E-01"},3,0,"M","D",".",0.77884,22,1,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",7882,0.72032,null,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,22,1,"Small GTP-binding protein domain (1);",null,"TCGA-Q3-A5QY-01A-12D-A32N-08",12,25289551,186,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HZ-A49I-01","TCGA-HZ-A49I-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",101,43,33,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,100,0.78595,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.654299,15813,".","SO:0001583",500,0.8502,0,1,1,0.80357,null,3845,78,5.68,".",1,".",7,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.86,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.505703,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.35,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.8439835,"d":"8.44E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,3,0,"M","D",".",0.77884,33,42,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,33,4,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A49I-01A-12D-A26I-08",12,25289551,185,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-AAUN-01","TCGA-IB-AAUN-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",221,76,119,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,217,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.495063,15813,".","SO:0001583",303,0.8502,0,1,1,0.80357,null,3845,116,5.68,".",1,".",9,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.8,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.98,"B;P","p.G12D","-",12,2229,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.88,"d":"8.80E-01"},0.626866,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.56,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,119,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.98979,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9884392,"d":"9.88E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,14,0,"M","D",".",0.77884,117,75,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5800,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,119,4,"Small GTP-binding protein domain (1);",null,"TCGA-IB-AAUN-01A-12D-A38G-08",12,25289551,335,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-A7LX-01","TCGA-IB-A7LX-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",222,230,84,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,4,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,214,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,3.113844,15813,".","SO:0001583",767,0.8502,0,1,1,0.80357,null,3845,210,5.68,".",1,".",26,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,3.15,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"B;P","p.G12D","-",12,4367,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.779951,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.55,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,84,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",1,"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,20,0,"M","D",".",0.77884,82,225,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",3666,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,84,6,"Small GTP-binding protein domain (1);",null,"TCGA-IB-A7LX-01A-12D-A36O-08",12,25289551,282,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-AAUM-01","TCGA-IB-AAUM-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",308,19,86,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,308,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,7,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.00172,15813,".","SO:0001583",346,0.8502,0,1,1,0.80357,null,3845,21,5.68,".",1,".",1,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-5.925615,2.04,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,{"v":0.998,"d":"9.98E-01"},"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"B;P","p.G12D","-",12,462,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.93,0.088387,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.08,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,86,"Familial Cancer Database",0,1,0,0.999992,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.995854,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.1649818,"d":"1.65E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999007,"d":"1.00E+00"},11,1,"M","D",".",0.77884,85,19,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7563,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,86,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-AAUM-01A-11D-A377-08",12,25289551,477,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25380275,25380275,"+","missense_variant","Missense_Mutation","SNP","T","T","G","rs17851045",null,"TCGA-FB-A5VM-01","TCGA-FB-A5VM-10",null,null,"T","G","T","T",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",235,35,57,0,"ENST00000256078.4:c.183A>C","p.Gln61His","p.Q61H","ENST00000256078","NM_033360.2",61,"caA/caC",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.326,0,246,3,0,21.3,"RASK_HUMAN",1,1,"c.183A>C","KRAS_ENST00000557334.1_Intron|AC087239.1_ENST00000594112.1_5'Flank|KRAS_ENST00000311936.3_Missense_Mutation_p.Q61H","-1.81;-1.81","Q",".;RASK_HUMAN","protein_coding",".",".",0.41828,230,0.84146,0,"12p12.1",null,null,0.91,0.91,null,"ENSP00000256078:Q61H","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.91146,2,2.006247,153,".","SO:0001583",610,0.43088,0,1,1,0.80357,null,3845,32,5.77,".",1,".",6,1,25349,4.13375,1,0.049057,0.33413,"c.(181-183)caA>caC","D",0.85682,null,null,-20,1.92,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","61;61",2,null,null,0.999,"Substitution - Missense(153)","Mis","T",0.533,1,"-",0.77,"B;B","p.Q61H","-",61,1302,"Noonan syndrome;Cardiofaciocutaneous syndrome","Q61H(CL11_LARGE_INTESTINE)|Q61H(HS766T_PANCREAS)|Q61H(NCIH1155_LUNG)|Q61H(NCIH460_LUNG)|Q61H(T3M4_PANCREAS)",0,0.87265,0,0.6134,"NM_033360.2",3.18,".",".",null,0,"0.0:0.0752:0.0:0.9248",0.98932,0.87829,".","ENST00000311936;ENST00000256078",2,"CAA",3,"D","ENSP00000308495:Q61H;ENSP00000256078:Q61H",5.77,"OTTHUMT00000412232.1","KNOWN",".",0.65,0.271845,1,null,".",0.77662,1,0.9114,1,"UBE2L3/KRAS(2)","H","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.28,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,57,"Familial Cancer Database",1,1,0,1,0,0.423,9.9836,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","TGTACTCCTCTTGACCTGCTG",0,"p.Q61H(153)","ENSG00000133703","yes","L, E, M, O",2,1,0.896985,0.78906,"NP_203524.1",1,"missense",0.80722,"0.092;0.151",{"v":0.5646846,"d":"5.65E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,8,0,"M","D",".",0.6212,57,35,".",".","P01116-2;P01116",0.2643,"P01116",1,"D;D","0.411;0.09",null,"KRAS",6692,0.72032,1,"CCDS8703.1","D",null,0.01,null,2.24,"g.chr12:25380275T>G",null,57,0,"Small GTP-binding protein domain (1);",null,"TCGA-FB-A5VM-01A-11D-A32N-08",12,25271542,301,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.32724,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-3A-A9IC-01","TCGA-3A-A9IC-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",216,48,101,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,211,0.78246,0,"12p12.1","GRCh37",null,0.99,0.99,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.928827,5144,".","SO:0001583",208,0.8502,0,1,1,0.80357,null,3845,40,5.68,".",1,".",6,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,1.8,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.87,"d":"8.70E-01"},"P;P","p.G12R","-",12,2177,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.75,"d":"7.50E-01"},0.37,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.37,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,101,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.956071,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.6716996,"d":"6.72E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,6,0,"M","D",".",0.77884,100,48,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",5834,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,101,2,"Small GTP-binding protein domain (1);",null,"TCGA-3A-A9IC-01A-11D-A38G-08",12,25289552,255,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-HZ-7919-01","TCGA-HZ-7919-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",82,36,14,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,81,0.78246,null,"12p12.1","GRCh37",null,0.99,0.99,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.514875,5144,".","SO:0001583",402,0.8502,0,1,1,0.80357,null,3845,182,5.68,".",1,".",26,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,1.87,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.99,"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.5,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.4,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.999996,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.9999963,"d":"1.00E+00"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,25,0,"M","D",".",0.77884,14,36,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,14,3,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-7919-01A-11D-2154-08",12,25289552,495,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-7893-01","TCGA-IB-7893-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",107,24,18,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,3,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,102,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.930904,15813,".","SO:0001583",314,0.8502,0,1,1,0.80357,null,3845,51,5.68,".",1,".",18,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-15.97822,3.31,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"B;P","p.G12D","-",12,2010,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.271218,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.21,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,18,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.99994,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9954361,"d":"9.95E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,24,0,"M","D",".",0.77884,18,24,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6004,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,18,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7893-01A-11D-2201-08",12,25289551,240,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-IB-7644-01","TCGA-IB-7644-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",77,15,17,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,27.2,"RASK_HUMAN",1,0.63,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,74,0.78707,null,"12p12.1",null,null,0.5,0.5,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.008958,15813,".","SO:0001583",449,0.8502,0,1,1,0.80357,null,3845,102,5.68,".",1,".",25,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-11.05792,1.91,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.39,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.3,0.630542,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.64,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,0.5,0,0.999896,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.515025,0.90789,"NP_203524.1",0.74,"missense",0.80722,"0.969;0.978",{"v":0.9986983,"d":"9.99E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,37,0,"M","D",".",0.77884,17,15,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,17,0,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7644-01A-11D-2154-08",12,25289551,343,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-HZ-A77P-01","TCGA-HZ-A77P-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",116,9,18,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,27.2,"RASK_HUMAN",1,{"v":0.89,"d":"8.90E-01"},"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,116,0.78707,0,"12p12.1",null,null,0.66,0.66,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.99921,15813,".","SO:0001583",438,0.8502,0,0,1,0.80357,null,3845,38,5.68,".",1,".",3,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-5.633668,1.99,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.48,"d":"4.80E-01"},"D;D","p.G12V","-",12,1231,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.33,0.21828,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.22,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,18,"Familial Cancer Database",1,1,0,0.994774,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.683693,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.3854232,"d":"3.85E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999993,"d":"1.00E+00"},14,0,"M","D",".",0.77884,18,9,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",6779,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,18,1,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A77P-01A-11D-A33T-08",12,25289551,470,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25380276,25380276,"+","missense_variant","Missense_Mutation","SNP","T","T","C","rs121913240",null,"TCGA-2L-AAQL-01","TCGA-2L-AAQL-11",null,null,"T","C","T","T",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",298,68,102,0,"ENST00000256078.4:c.182A>G","p.Gln61Arg","p.Q61R","ENST00000256078","NM_033360.2",61,"cAa/cGa",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.326,0,245,2,0,20.6,"RASK_HUMAN",1,1,"c.182A>G","KRAS_ENST00000557334.1_Intron|AC087239.1_ENST00000594112.1_5'Flank|KRAS_ENST00000311936.3_Missense_Mutation_p.Q61R","-1.75;-1.75","Q",".;RASK_HUMAN","protein_coding",".",".",0.76373,293,0.83673,0,"12p12.1",null,null,0.93,0.93,null,"ENSP00000256078:Q61R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.91146,2,2.018804,141,".","SO:0001583",451,0.8814,0,1,1,0.80357,null,3845,107,5.77,".",1,".",1,1,25349,4.022613,1,0.049057,0.26744,"c.(181-183)cAa>cGa","D",0.85682,null,null,-20,1.79,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","61;61",2,null,null,0.999,"Substitution - Missense(141)","Mis","T",0.533,1,"-",0.84,"B;B","p.Q61R","-",61,1264,"Noonan syndrome;Cardiofaciocutaneous syndrome","Q61L(NCIH650_LUNG)|Q61L(SW948_LARGE_INTESTINE)|Q61R(PANC0213_PANCREAS)",0,0.88358,0,0.6415,"NM_033360.2",3.3,".",".",null,0,"0.0:0.0:0.0:1.0",0.98932,0.87885,".","ENST00000311936;ENST00000256078",0,"CAA",3,"D","ENSP00000308495:Q61R;ENSP00000256078:Q61R",5.77,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.74,"d":"7.40E-01"},0.358045,1,null,".",0.75275,1,0.92367,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.38,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,102,"Familial Cancer Database",0,1,0,1,0,0.418,15.5753,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GTACTCCTCTTGACCTGCTGT",0,"p.Q61L(73)|p.Q61R(56)|p.Q61P(12)","ENSG00000133703","yes","L, E, M, O",2,1,0.927625,0.78906,"NP_203524.1",1,"missense",0.80722,"0.135;0.153",{"v":0.6358014,"d":"6.36E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,10,0,"M","D",".",0.6212,102,66,".",".","P01116-2;P01116",0.268,"P01116",1,"D;D","0.158;0.026",null,"KRAS",6758,0.66056,1,"CCDS8703.1","D",null,0.02,null,7.983,"g.chr12:25380276T>C",null,102,0,"Small GTP-binding protein domain (1);",null,"TCGA-2L-AAQL-01A-11D-A38G-08",12,25271543,675,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.32805,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-2J-AABE-01","TCGA-2J-AABE-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",163,28,57,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,97,1,2,28.6,"RASK_HUMAN",1,0.92,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,163,0.78246,null,"12p12.1","GRCh37",null,0.77,0.77,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.005348,5144,".","SO:0001583",334,0.8502,0,1,1,0.80357,null,3845,24,5.68,".",1,".",4,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-15.16063,1.99,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.64,"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.53,"d":"5.30E-01"},0.381176,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.38,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.781413,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.6350969,"d":"6.35E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,10,0,"M","D",".",0.77884,57,28,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,57,3,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABE-01A-12D-A40W-08",12,25289552,252,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-A5SO-01","TCGA-IB-A5SO-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",77,9,26,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,76,0.78595,0,"12p12.1",null,null,0.97,0.97,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.077328,15813,".","SO:0001583",283,0.8502,0,1,1,0.80357,null,3845,34,5.68,".",1,".",13,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-6.860924,1.87,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.69,"B;P","p.G12D","-",12,901,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.48,0.240481,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.23,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,26,"Familial Cancer Database",1,1,0,0.994775,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.880578,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9356873,"d":"9.36E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,31,0,"M","D",".",{"v":0.77884,"d":"7.79E-01"},26,9,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7113,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,26,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-A5SO-01A-11D-A32N-08",12,25289551,461,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913530",null,"TCGA-IB-7886-01","TCGA-IB-7886-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",66,157,14,0,"ENST00000256078.4:c.34G>T","p.Gly12Cys","p.G12C","ENST00000256078","NM_033360.2",12,"Ggt/Tgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,7,25.8,"RASK_HUMAN",1,1,"c.34G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000311936.3_Missense_Mutation_p.G12C","-1.24;-1.24;-1.24;-1.24","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,66,0.79141,0,"12p12.1","GRCh37",null,0.99,0.99,null,"ENSP00000256078:G12C","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,3.950103,5144,".","SO:0001583",403,0.8502,0,1,1,0.80357,null,3845,508,5.68,".",1,".",46,1,25349,4.676185,1,0,0.89917,"c.(34-36)Ggt>Tgt","D",0.85682,null,"M",-20,2.62,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.99,"D;D","p.G12C","-",12,6175,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",2,0.90466,121404,0.7014,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91833,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12C;ENSP00000452512:G12C;ENSP00000256078:G12C;ENSP00000451856:G12C",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.783401,1,null,".",0.88445,1,0.9065,1,"UBE2L3/KRAS(2)","C","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.51,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",38,14,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.993;0.993",1,"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,17,0,"M","D",".",0.77884,14,155,".",".","P01116-2;P01116",0.5477,"P01116",1,"T;T;T;T","1.0;1.0","CM076251","KRAS",1843,0.72032,1,"CCDS8703.1","D","rs121913530",0.01,null,7.743,"g.chr12:25398285C>A",null,14,7,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7886-01A-11D-2154-08",12,25289552,207,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.79784,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-AAUP-01","TCGA-IB-AAUP-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",326,13,70,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,0.84,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,322,0.78595,0,"12p12.1",null,null,0.55,0.55,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.017654,15813,".","SO:0001583",284,0.8502,0,1,1,0.80357,null,3845,25,5.68,".",1,".",4,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-4.150761,2.1,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.41,"B;P","p.G12D","-",12,695,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.3,0.160701,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.15,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,70,"Familial Cancer Database",1,0.52,0,0.999522,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.605844,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.1700908,"d":"1.70E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999231,"d":"1.00E+00"},14,0,"M","D",".",0.77884,68,13,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7323,0.87932,0,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,70,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-AAUP-01A-11D-A377-08",12,25289551,409,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-FB-AAPQ-01","TCGA-FB-AAPQ-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","RNA",null,null,"Illumina GAIIx",142,45,102,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,null,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,141,0.78595,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,null,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.097227,15813,".","SO:0001583",null,0.8502,0,0,1,0.80357,null,3845,null,5.68,".",1,".",25,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.9,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.91,"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.79,"d":"7.90E-01"},0.477369,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.47,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.967915,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9998213,"d":"1.00E+00"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",null,20,null,"M","D",".",0.77884,102,45,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,0,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,102,3,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAPQ-01A-11D-A40W-08",12,25289551,null,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-F2-A7TX-01","TCGA-F2-A7TX-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",273,51,122,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,269,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.048859,15813,".","SO:0001583",248,0.8502,0,1,1,0.80357,null,3845,72,5.68,".",1,".",10,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,3.45,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"B;P","p.G12D","-",12,1877,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.308284,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.19,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,122,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9833576,"d":"9.83E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,27,0,"M","D",".",0.77884,120,51,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6137,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,122,4,"Small GTP-binding protein domain (1);",null,"TCGA-F2-A7TX-01A-33D-A38G-08",12,25289551,332,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
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[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-YY-A8LH-01","TCGA-YY-A8LH-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",237,97,95,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,235,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.022142,15813,".","SO:0001583",353,0.8502,0,1,1,0.80357,null,3845,72,5.68,".",1,".",16,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,3.73,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"D;D","p.G12V","-",12,3123,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.698997,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.55,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,95,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.9980131,"d":"9.98E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,10,0,"M","D",".",0.77884,93,96,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",4899,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,95,4,"Small GTP-binding protein domain (1);",null,"TCGA-YY-A8LH-01A-11D-A36O-08",12,25289551,221,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-HV-A5A4-01","TCGA-HV-A5A4-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",79,66,6,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,79,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.62408,15813,".","SO:0001583",467,0.8502,0,0,1,0.80357,null,3845,209,5.68,".",1,".",6,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"D;D","p.G12V","-",12,3723,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.65625,0,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.56,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,6,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.9986447,"d":"9.99E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,10,0,"M","D",".",0.77884,6,66,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",4285,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,6,3,"Small GTP-binding protein domain (1);",null,"TCGA-HV-A5A4-01A-11D-A26I-08",12,25289551,441,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-2J-AAB1-01","TCGA-2J-AAB1-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",199,8,53,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,0.29,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,199,0.78595,null,"12p12.1",null,null,0.2,0.2,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.993904,15813,".","SO:0001583",365,0.8502,0,1,1,0.80357,null,3845,11,5.68,".",1,".",1,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-4.074507,1.94,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.14,"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.09,"d":"9.00E-02"},0.370431,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.38,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",0,0.2,0,0.989787,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.221373,0.90789,"NP_203524.1",0.37,"missense",0.80722,"0.257;0.361",{"v":0.1537874,"d":"1.54E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9993325,"d":"9.99E-01"},15,0,"M","D",".",0.77884,51,8,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,53,0,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AAB1-01A-11D-A40W-08",12,25289551,354,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-S4-A8RM-01","TCGA-S4-A8RM-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",228,82,51,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,0.91,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,225,0.78707,0,"12p12.1",null,null,0.82,0.82,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.030759,15813,".","SO:0001583",247,0.8502,0,1,1,0.80357,null,3845,111,5.68,".",1,".",27,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,1.98,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.74,"d":"7.40E-01"},"D;D","p.G12V","-",12,2492,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.67,"d":"6.70E-01"},0.641148,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.64,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,51,"Familial Cancer Database",1,0.83,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.831894,0.90789,"NP_203524.1",0.99,"missense",0.80722,"0.969;0.978",{"v":0.9999627,"d":"1.00E+00"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,18,0,"M","D",".",0.77884,51,82,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",5524,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,51,3,"Small GTP-binding protein domain (1);",null,"TCGA-S4-A8RM-01A-11D-A377-08",12,25289551,310,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-H6-8124-01","TCGA-H6-8124-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",27,61,15,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,27,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.354604,15813,".","SO:0001583",435,0.8502,0,1,1,0.80357,null,3845,207,5.68,".",1,".",17,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,1.77,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"D;D","p.G12V","-",12,5456,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.7,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.7,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,15,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.9999999,"d":"1.00E+00"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,3,0,"M","D",".",0.77884,15,61,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",2557,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,15,2,"Small GTP-binding protein domain (1);",null,"TCGA-H6-8124-01A-11D-2396-08",12,25289551,129,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-2J-AABU-01","TCGA-2J-AABU-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",146,80,84,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,97,1,3,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,145,0.78246,null,"12p12.1","GRCh37",null,0.99,0.99,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.973774,5144,".","SO:0001583",272,0.8502,0,1,1,0.80357,null,3845,84,5.68,".",1,".",5,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,1.83,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.655963,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.52,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.9570018,"d":"9.57E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,7,0,"M","D",".",0.77884,82,80,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,84,4,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABU-01A-11D-A40W-08",12,25289552,180,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-7651-01","TCGA-IB-7651-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",89,13,17,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,85,0.78595,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.002308,15813,".","SO:0001583",418,0.8502,0,0,1,0.80357,null,3845,76,5.68,".",1,".",14,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-8.892211,2.06,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.86,{"v":0.1756059,"d":"1.76E-01"},1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.17,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,1,0,{"v":0.9995158,"d":"1.00E+00"},0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.991831,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9775702,"d":"9.78E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,33,0,"M","D",".",0.77884,17,12,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,17,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7651-01A-11D-2154-08",12,25289551,450,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25380276,25380276,"+","missense_variant","Missense_Mutation","SNP","T","T","C","rs121913240",null,"TCGA-IB-7890-01","TCGA-IB-7890-10",null,null,"T","C","T","T",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",305,131,53,0,"ENST00000256078.4:c.182A>G","p.Gln61Arg","p.Q61R","ENST00000256078","NM_033360.2",61,"cAa/cGa",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.326,3,245,2,4,20.6,"RASK_HUMAN",1,1,"c.182A>G","KRAS_ENST00000557334.1_Intron|AC087239.1_ENST00000594112.1_5'Flank|KRAS_ENST00000311936.3_Missense_Mutation_p.Q61R","-1.75;-1.75","Q",".;RASK_HUMAN","protein_coding",".",".",0.76373,300,0.83673,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:Q61R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.91146,2,2.408262,141,".","SO:0001583",889,0.8814,0,1,1,0.80357,null,3845,238,5.77,".",1,".",13,1,25349,4.022613,1,0.049057,0.26744,"c.(181-183)cAa>cGa","D",0.85682,null,null,-20,2.8,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","61;61",2,null,null,0.999,"Substitution - Missense(141)","Mis","T",0.533,1,"-",0.99,"B;B","p.Q61R","-",61,2290,"Noonan syndrome;Cardiofaciocutaneous syndrome","Q61L(NCIH650_LUNG)|Q61L(SW948_LARGE_INTESTINE)|Q61R(PANC0213_PANCREAS)",0,0.88358,0,0.6415,"NM_033360.2",3.3,".",".",null,0,"0.0:0.0:0.0:1.0",0.98932,0.87885,".","ENST00000311936;ENST00000256078",0,"CAA",3,"D","ENSP00000308495:Q61R;ENSP00000256078:Q61R",5.77,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.535559,1,null,".",0.75275,1,0.92367,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.36,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,53,"Familial Cancer Database",1,1,1,1,0,0.418,15.5753,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GTACTCCTCTTGACCTGCTGT",0,"p.Q61L(73)|p.Q61R(56)|p.Q61P(12)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.78906,"NP_203524.1",1,"missense",0.80722,"0.135;0.153",1,"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,56,0,"M","D",".",0.6212,53,130,".",".","P01116-2;P01116",0.268,"P01116",1,"D;D","0.158;0.026",null,"KRAS",5741,0.66056,1,"CCDS8703.1","D",null,0.02,null,7.983,"g.chr12:25380276T>C",null,53,7,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7890-01A-12D-2201-08",12,25271543,705,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.32805,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HV-A5A6-01","TCGA-HV-A5A6-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",57,33,12,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,57,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.008545,15813,".","SO:0001583",453,0.8502,0,1,1,0.80357,null,3845,140,5.68,".",1,".",10,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.94,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.97,"B;P","p.G12D","-",12,2831,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.83,0.635332,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.64,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,12,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.984274,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9926599,"d":"9.93E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,7,0,"M","D",".",0.77884,12,32,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5201,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,12,0,"Small GTP-binding protein domain (1);",null,"TCGA-HV-A5A6-01A-11D-A26I-08",12,25289551,334,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HZ-A4BK-01","TCGA-HZ-A4BK-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",81,37,13,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,3,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,79,0.78595,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.509416,15813,".","SO:0001583",476,0.8502,0,1,1,0.80357,null,3845,193,5.68,".",1,".",16,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.79,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.447334,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.32,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9985002,"d":"9.99E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,10,0,"M","D",".",0.77884,13,37,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,13,4,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A4BK-01A-11D-A26I-08",12,25289551,440,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-FB-AAPY-01","TCGA-FB-AAPY-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",190,22,61,1,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,188,0.78595,null,"12p12.1",null,null,0.85,0.85,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.104873,15813,".","SO:0001583",273,0.8502,0,0,1,0.80357,null,3845,29,5.68,".",1,".",1,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-10.13315,1.92,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.68,"d":"6.80E-01"},"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,1,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.54,0.27692,0,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.26,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",0,1,0,0.958067,1,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",13,1,0.844974,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.2110806,"d":"2.11E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,6,0,"M","D",".",0.77884,58,22,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,61,3,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAPY-01A-11D-A40W-08",12,25289551,255,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-A6UG-01","TCGA-IB-A6UG-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",117,13,20,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,117,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.07598,15813,".","SO:0001583",273,0.8502,0,0,1,0.80357,null,3845,75,5.68,".",1,".",8,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-7.680973,3.28,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.86,"d":"8.60E-01"},"B;P","p.G12D","-",12,1812,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.63,0.342881,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.22,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,20,"Familial Cancer Database",1,1,0,0.999626,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.949861,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.5381532,"d":"5.38E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,9,0,"M","D",".",0.77884,20,13,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6219,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,20,4,"Small GTP-binding protein domain (1);",null,"TCGA-IB-A6UG-01A-32D-A33T-08",12,25289551,401,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-HZ-A49H-01","TCGA-HZ-A49H-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",98,15,10,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,97,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.005415,15813,".","SO:0001583",415,0.8502,0,0,1,0.80357,null,3845,70,5.68,".",1,".",6,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-9.786752,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"D;D","p.G12V","-",12,1718,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.062885,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.05,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,10,"Familial Cancer Database",1,1,0,0.999904,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.999999,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.454392,"d":"4.54E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,5,0,"M","D",".",0.77884,10,15,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",6247,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,10,3,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A49H-01A-11D-A26I-08",12,25289551,462,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-2J-AABK-01","TCGA-2J-AABK-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",169,15,60,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,167,0.78707,null,"12p12.1",null,null,0.8,0.8,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.002578,15813,".","SO:0001583",415,0.8502,0,1,1,0.80357,null,3845,26,5.68,".",1,".",2,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-7.101348,1.88,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.62,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.47,0.188641,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.2,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,0,0.999884,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.804655,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.338032,"d":"3.38E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999999,"d":"1.00E+00"},12,0,"M","D",".",0.77884,60,15,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,60,0,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABK-01A-31D-A40W-08",12,25289551,378,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-3A-A9IZ-01","TCGA-3A-A9IZ-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",151,56,59,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,150,0.78595,null,"12p12.1",null,null,0.96,0.96,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.023893,15813,".","SO:0001583",274,0.8502,0,1,1,0.80357,null,3845,74,5.68,".",1,".",19,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.96,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.85,"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.75,"d":"7.50E-01"},0.56,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.56,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.939583,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9980812,"d":"9.98E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,10,0,"M","D",".",0.77884,57,54,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,59,0,"Small GTP-binding protein domain (1);",null,"TCGA-3A-A9IZ-01A-12D-A40W-08",12,25289551,273,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HV-AA8X-01","TCGA-HV-AA8X-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",156,50,37,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,154,0.78595,11,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.580085,15813,".","SO:0001583",431,0.8502,0,1,1,0.80357,null,3845,134,5.68,".",1,".",17,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.93,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",21,null,null,{"v":0.998,"d":"9.98E-01"},"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.87,"B;P","p.G12D","-",12,2547,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.76,"d":"7.60E-01"},0.707417,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.63,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,8006,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.956221,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9976111,"d":"9.98E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,13,0,"M","D",".",0.77884,37,50,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5486,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,37,4,"Small GTP-binding protein domain (1);",null,"TCGA-HV-AA8X-01A-11D-A397-08",12,25289551,392,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-2J-AABV-01","TCGA-2J-AABV-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",220,11,90,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,217,0.78707,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.072621,15813,".","SO:0001583",162,0.8502,0,1,1,0.80357,null,3845,16,5.68,".",1,".",0,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-4.629783,2.01,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.71,"d":"7.10E-01"},"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.5,0.133356,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.11,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",0,1,0,0.998334,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.892641,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",0,"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999582,"d":"1.00E+00"},1,0,"M","D",".",0.77884,90,11,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,90,3,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABV-01A-12D-A40W-08",12,25289551,388,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-YB-A89D-01","TCGA-YB-A89D-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",397,6,85,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,{"v":0.22,"d":"2.20E-01"},"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,393,0.78595,0,"12p12.1",null,null,0.14,0.14,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.987213,15813,".","SO:0001583",308,0.8502,0,0,1,0.80357,null,3845,3,5.68,".",1,".",0,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-3.335946,3.28,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.09,"d":"9.00E-02"},"B;P","p.G12D","-",12,175,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.05,0.321429,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.24,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,85,"Familial Cancer Database",0,0.15,1,0.964156,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.160471,0.90789,"NP_203524.1",0.29,"missense",0.80722,"0.257;0.361",{"v":0.07864706,"d":"7.86E-02"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.8764639,"d":"8.76E-01"},26,0,"M","D",".",0.77884,83,6,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7854,0.87932,0,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,85,3,"Small GTP-binding protein domain (1);",null,"TCGA-YB-A89D-01A-12D-A36O-08",12,25289551,248,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HZ-8002-01","TCGA-HZ-8002-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",113,9,24,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,110,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.998225,15813,".","SO:0001583",402,0.8502,0,0,1,0.80357,null,3845,44,5.68,".",1,".",0,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-5.707509,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"B;P","p.G12D","-",12,840,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.7,0.094112,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.1,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,24,"Familial Cancer Database",0,1,0,{"v":0.9941519,"d":"9.94E-01"},0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.975434,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.4941126,"d":"4.94E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999998,"d":"1.00E+00"},20,0,"M","D",".",0.77884,24,9,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7114,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,24,1,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-8002-01A-11D-2201-08",12,25289551,555,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-FB-A4P5-01","TCGA-FB-A4P5-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",91,2,15,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,0.85,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,90,0.78595,0,"12p12.1",null,null,0.43,0.43,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.009941,15813,".","SO:0001583",180,0.8502,0,null,1,0.80357,null,3845,7,5.68,".",1,".",1,{"v":0.999994,"d":"1.00E+00"},25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-3.568862,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.21,"B;P","p.G12D","-",12,353,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.09,0.136176,null,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.13,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,15,"Familial Cancer Database",0,1,0,0.681391,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,null,0.498729,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.007364601,"d":"7.36E-03"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9683217,"d":"9.68E-01"},3,0,"M","D",".",0.77884,15,2,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7668,0.87932,null,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,15,3,"Small GTP-binding protein domain (1);",null,"TCGA-FB-A4P5-01A-11D-A26I-08",12,25289551,341,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-IB-7885-01","TCGA-IB-7885-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",88,7,38,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,88,0.78707,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.11357,15813,".","SO:0001583",408,0.8502,0,1,1,0.80357,null,3845,33,5.68,".",1,".",7,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-5.394511,1.73,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.7,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.46,0.177116,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.16,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,0.981954,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.892419,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.6948953,"d":"6.95E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999989,"d":"1.00E+00"},24,0,"M","D",".",0.77884,37,7,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,38,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7885-01A-11D-2154-08",12,25289551,540,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-7897-01","TCGA-IB-7897-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",173,1,20,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,0.25,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,0,0.78595,0,"12p12.1",null,null,0.11,0.11,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.001917,15813,".","SO:0001583",255,0.8502,0,null,1,0.80357,null,3845,8,5.68,".",1,".",5,{"v":0.9986617,"d":"9.99E-01"},25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-3.039667,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.04,"B;P","p.G12D","-",12,96,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.01,0.163347,null,null,".",0.8334,0,0.91818,null,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.16,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,20,"Familial Cancer Database",1,0.07,0,0,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,null,0.172109,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.09654497,"d":"9.65E-02"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.7486278,"d":"7.49E-01"},37,0,"M","D",".",0.77884,0,0,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7928,0.87932,null,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,20,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7897-01A-21D-2201-08",12,25289551,351,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-A7M4-01","TCGA-IB-A7M4-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",289,81,89,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,288,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.019051,15813,".","SO:0001583",305,0.8502,0,1,1,0.80357,null,3845,72,5.68,".",1,".",9,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.98,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.89,"B;P","p.G12D","-",12,1858,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.81,0.441229,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.44,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,89,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.961391,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9590678,"d":"9.59E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,12,0,"M","D",".",0.77884,88,81,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6158,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,89,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-A7M4-01A-11D-A36O-08",12,25289551,304,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-H6-A45N-01","TCGA-H6-A45N-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",92,5,10,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,92,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.004033,15813,".","SO:0001583",380,0.8502,0,0,1,0.80357,null,3845,36,5.68,".",1,".",0,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-4.444013,2.03,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.65,"D;D","p.G12V","-",12,998,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.39,0.116801,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.11,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,10,"Familial Cancer Database",0,1,0,0.939226,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.871696,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.06845045,"d":"6.85E-02"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999694,"d":"1.00E+00"},7,0,"M","D",".",0.77884,10,5,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",7014,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,10,3,"Small GTP-binding protein domain (1);",null,"TCGA-H6-A45N-01A-11D-A26I-08",12,25289551,601,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-XD-AAUL-01","TCGA-XD-AAUL-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",271,34,99,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,0,28.6,"RASK_HUMAN",1,0.75,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,271,0.78246,1,"12p12.1","GRCh37",null,0.64,0.64,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.011841,5144,".","SO:0001583",339,0.8502,0,1,1,0.80357,null,3845,56,5.68,".",1,".",8,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-13.88568,1.88,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",17,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.54,"P;P","p.G12R","-",12,1365,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.45,"d":"4.50E-01"},0.328586,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.34,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,8016,"Familial Cancer Database",1,0.64,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.654766,0.90789,"NP_203524.1",0.85,"missense",0.80722,"0.36;0.562",{"v":0.6988829,"d":"6.99E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,13,0,"M","D",".",0.77884,98,34,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",6666,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,99,0,"Small GTP-binding protein domain (1);",null,"TCGA-XD-AAUL-01A-21D-A397-08",12,25289552,356,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HZ-A8P1-01","TCGA-HZ-A8P1-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",183,73,84,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,0.9,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,180,0.78595,0,"12p12.1",null,null,0.81,0.81,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.014243,15813,".","SO:0001583",443,0.8502,0,1,1,0.80357,null,3845,140,5.68,".",1,".",16,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.88,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.73,"d":"7.30E-01"},"B;P","p.G12D","-",12,2713,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.66,"d":"6.60E-01"},0.658562,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.67,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,84,"Familial Cancer Database",1,0.82,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.82524,0.90789,"NP_203524.1",0.98,"missense",0.80722,"0.257;0.361",{"v":0.9993604,"d":"9.99E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,15,0,"M","D",".",0.77884,84,71,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5318,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,84,0,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A8P1-01A-11D-A377-08",12,25289551,407,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25380275,25380275,"+","missense_variant","Missense_Mutation","SNP","T","T","A","rs17851045",null,"TCGA-HZ-A8P0-01","TCGA-HZ-A8P0-10",null,null,"T","A","T","T",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",280,72,68,0,"ENST00000256078.4:c.183A>T","p.Gln61His","p.Q61H","ENST00000256078","NM_033360.2",61,"caA/caT",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.326,0,246,3,0,22.1,"RASK_HUMAN",1,1,"c.183A>T","KRAS_ENST00000557334.1_Intron|AC087239.1_ENST00000594112.1_5'Flank|KRAS_ENST00000311936.3_Missense_Mutation_p.Q61H","-1.81;-1.81","Q",".;RASK_HUMAN","protein_coding",".",".",0.41828,277,0.84146,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:Q61H","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.91146,2,1.998835,153,".","SO:0001583",931,0.43088,0,1,1,0.80357,null,3845,197,5.77,".",1,".",6,1,25349,4.243092,1,0.049057,0.33413,"c.(181-183)caA>caT","D",0.85682,null,null,-20,1.96,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","61;61",2,null,null,0.999,"Substitution - Missense(153)","Mis","T",0.533,1,"-",{"v":0.95,"d":"9.50E-01"},"B;B","p.Q61H","-",61,1372,"Noonan syndrome;Cardiofaciocutaneous syndrome","Q61H(CL11_LARGE_INTESTINE)|Q61H(HS766T_PANCREAS)|Q61H(NCIH1155_LUNG)|Q61H(NCIH460_LUNG)|Q61H(T3M4_PANCREAS)",0,0.87265,0,0.6134,"NM_033360.2",3.18,".",".",null,0,"0.0:0.0752:0.0:0.9248",0.98932,0.87829,".","ENST00000311936;ENST00000256078",2,"CAA",3,"D","ENSP00000308495:Q61H;ENSP00000256078:Q61H",5.77,"OTTHUMT00000412232.1","KNOWN","rs17851045",{"v":0.85,"d":"8.50E-01"},0.375252,1,null,".",0.79912,1,0.9114,1,"UBE2L3/KRAS(2)","H","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.38,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,68,"Familial Cancer Database",1,1,0,1,0,0.423,9.9836,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","TGTACTCCTCTTGACCTGCTG",0,"p.Q61H(153)","ENSG00000133703","yes","L, E, M, O",2,1,0.983073,0.78906,"NP_203524.1",1,"missense",0.80722,"0.092;0.151",{"v":0.9732354,"d":"9.73E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,19,0,"M","D",".",0.6212,68,69,".",".","P01116-2;P01116",0.2643,"P01116",1,"D;D","0.411;0.09",null,"KRAS",6654,0.72032,1,"CCDS8703.1","D",null,0.01,null,2.24,"g.chr12:25380275T>A",null,68,0,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A8P0-01A-11D-A36O-08",12,25271542,939,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.32724,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-3A-A9IB-01","TCGA-3A-A9IB-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",244,66,65,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,243,0.78595,19,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.053135,15813,".","SO:0001583",223,0.8502,0,1,1,0.80357,null,3845,75,5.68,".",1,".",13,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.97,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",31,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"B;P","p.G12D","-",12,2089,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.94,"d":"9.40E-01"},0.408115,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.38,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,7994,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.996734,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9876195,"d":"9.88E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,15,0,"M","D",".",0.77884,64,66,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5927,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,65,3,"Small GTP-binding protein domain (1);",null,"TCGA-3A-A9IB-01A-21D-A397-08",12,25289551,311,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-FB-A545-01","TCGA-FB-A545-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",67,38,13,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,6,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,66,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.179788,15813,".","SO:0001583",271,0.8502,0,1,1,0.80357,null,3845,103,5.68,".",1,".",7,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,3.13,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"D;D","p.G12V","-",12,3587,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.671168,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.53,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,13,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.8861739,"d":"8.86E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,2,0,"M","D",".",0.77884,13,37,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",4415,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,13,8,"Small GTP-binding protein domain (1);",null,"TCGA-FB-A545-01A-11D-A26I-08",12,25289551,193,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-FB-AAQ6-01","TCGA-FB-AAQ6-11",{"$nulls":7},"Untested","Somatic","Phase_I","WXS","none",null,null,"Illumina GAIIx",170,48,100,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,null,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,27.2,"RASK_HUMAN",1,0.76,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,170,0.78707,null,"12p12.1",null,null,0.66,0.66,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,null,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.011783,15813,".","SO:0001583",null,0.8502,0,0,1,0.80357,null,3845,null,5.68,".",1,".",8,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,1.87,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.58,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.51,"d":"5.10E-01"},0.615465,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.63,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,0.67,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.678396,0.90789,"NP_203524.1",0.84,"missense",0.80722,"0.969;0.978",{"v":0.8133115,"d":"8.13E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",null,5,null,"M","D",".",0.77884,100,47,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,0,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,100,0,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAQ6-01A-11D-A40W-08",12,25289551,null,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-A5ST-01","TCGA-IB-A5ST-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",93,4,18,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,92,0.78595,0,"12p12.1",null,null,0.93,0.93,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.99809,15813,".","SO:0001583",211,0.8502,0,0,1,0.80357,null,3845,5,5.68,".",1,".",8,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-4.082842,2.04,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.56,"B;P","p.G12D","-",12,438,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.31,0.106256,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.1,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,18,"Familial Cancer Database",1,1,0,0.88943,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.824213,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.3527587,"d":"3.53E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9908627,"d":"9.91E-01"},17,0,"M","D",".",0.77884,18,4,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7599,0.87932,0,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,18,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-A5ST-01A-11D-A32N-08",12,25289551,232,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HZ-A49G-01","TCGA-HZ-A49G-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",131,12,15,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,130,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.008939,15813,".","SO:0001583",424,0.8502,0,0,1,0.80357,null,3845,36,5.68,".",1,".",3,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-6.683395,1.82,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.82,"B;P","p.G12D","-",12,575,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.61,0.138368,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.15,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,15,"Familial Cancer Database",1,1,0,0.999217,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.938882,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.2264209,"d":"2.26E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,7,0,"M","D",".",0.77884,15,12,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7461,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,15,0,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A49G-01A-11D-A26I-08",12,25289551,467,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-3A-A9I7-01","TCGA-3A-A9I7-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",295,23,111,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,23.4,"RASK_HUMAN",1,0.92,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,285,0.78595,0,"12p12.1",null,null,0.75,0.75,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.010853,15813,".","SO:0001583",199,0.8502,0,1,1,0.80357,null,3845,21,5.68,".",1,".",4,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-7.66547,1.94,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.61,"B;P","p.G12D","-",12,643,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.49,0.18691,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.19,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,111,"Familial Cancer Database",1,1,0,0.999999,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.769312,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.5773374,"d":"5.77E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999999,"d":"1.00E+00"},22,0,"M","D",".",0.77884,111,22,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7367,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,111,1,"Small GTP-binding protein domain (1);",null,"TCGA-3A-A9I7-01A-21D-A38G-08",12,25289551,347,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-US-A774-01","TCGA-US-A774-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",96,5,15,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,95,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.068484,15813,".","SO:0001583",322,0.8502,0,0,1,0.80357,null,3845,17,5.68,".",1,".",6,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-4.379355,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.74,"d":"7.40E-01"},"B;P","p.G12D","-",12,322,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.44,0.120664,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.1,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,15,"Familial Cancer Database",1,1,0,0.937533,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.911241,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.5997426,"d":"6.00E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9979955,"d":"9.98E-01"},31,0,"M","D",".",0.77884,15,5,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7702,0.87932,0,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,15,3,"Small GTP-binding protein domain (1);",null,"TCGA-US-A774-01A-21D-A32N-08",12,25289551,255,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-3A-A9I9-01","TCGA-3A-A9I9-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",286,36,106,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,1,28.6,"RASK_HUMAN",1,{"v":0.73,"d":"7.30E-01"},"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,282,0.78246,0,"12p12.1","GRCh37",null,0.62,0.62,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.744959,5144,".","SO:0001583",222,0.8502,0,1,1,0.80357,null,3845,40,5.68,".",1,".",1,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-14.46722,1.87,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.53,"d":"5.30E-01"},"P;P","p.G12R","-",12,2031,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.45,0.176471,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.3,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,106,"Familial Cancer Database",0,0.62,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.637571,0.90789,"NP_203524.1",0.82,"missense",0.80722,"0.36;0.562",{"v":0.01335233,"d":"1.34E-02"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,1,0,"M","D",".",0.77884,106,36,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",5987,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,106,1,"Small GTP-binding protein domain (1);",null,"TCGA-3A-A9I9-01A-11D-A38G-08",12,25289552,282,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-Z5-AAPL-01","TCGA-Z5-AAPL-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",213,5,60,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,0.88,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,212,0.78707,null,"12p12.1",null,null,0.52,0.52,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.000035,15813,".","SO:0001583",327,0.8502,0,0,1,0.80357,null,3845,6,5.68,".",1,".",1,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-3.509279,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.32,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.19,0.105812,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.1,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",0,1,0,0.937507,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.573928,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.03838478,"d":"3.84E-02"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9900869,"d":"9.90E-01"},10,0,"M","D",".",0.77884,59,5,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,0,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,60,3,"Small GTP-binding protein domain (1);",null,"TCGA-Z5-AAPL-01A-12D-A40W-08",12,25289551,386,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-8126-01","TCGA-IB-8126-10",{"$nulls":7},"Untested","Somatic","Phase_I","WXS","none",null,null,"Illumina GAIIx",80,0,25,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,null,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,{"v":0.55,"d":"5.50E-01"},"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,79,0.78595,0,"12p12.1",null,null,0.18,0.18,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,null,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,null,2.003616,15813,".","SO:0001583",365,0.8502,0,null,1,0.80357,null,3845,7,5.68,".",1,".",0,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-2.752535,3.97,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.04,"d":"4.00E-02"},"B;P","p.G12D","-",12,1055,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0,0.129187,null,null,".",0.8334,0,0.91818,null,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.09,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,25,"Familial Cancer Database",null,0.01,0,null,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",null,null,0.287707,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",null,"B;B","pancreatic, colorectal, lung, thyroid, AML, others",null,15,0,"M","D",".",0.77884,25,0,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6830,0.87932,null,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,25,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-8126-01A-11D-2396-08",12,25289551,371,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-IB-AAUU-01","TCGA-IB-AAUU-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",233,70,67,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,97,1,5,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,232,0.78246,0,"12p12.1","GRCh37",null,0.99,0.99,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.124773,5144,".","SO:0001583",347,0.8502,0,1,1,0.80357,null,3845,93,5.68,".",1,".",17,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,3.3,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.99,"P;P","p.G12R","-",12,2913,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.52073,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.37,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,67,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.9967793,"d":"9.97E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,15,0,"M","D",".",0.77884,67,69,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",5108,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,67,7,"Small GTP-binding protein domain (1);",null,"TCGA-IB-AAUU-01A-11D-A377-08",12,25289552,272,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-HZ-7925-01","TCGA-HZ-7925-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",113,14,28,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,113,0.78707,0,"12p12.1",null,null,0.9,0.9,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.003904,15813,".","SO:0001583",321,0.8502,0,1,1,0.80357,null,3845,44,5.68,".",1,".",8,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-8.430733,1.91,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,{"v":0.998,"d":"9.98E-01"},"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.7,"D;D","p.G12V","-",12,910,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.53,0.230769,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.24,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,28,"Familial Cancer Database",1,1,0,0.999812,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.871138,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.8728364,"d":"8.73E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,24,0,"M","D",".",0.77884,28,14,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",7111,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,28,0,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-7925-01A-11D-2154-08",12,25289551,543,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-F2-6879-01","TCGA-F2-6879-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",52,43,21,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,null,98,2,null,27.2,"RASK_HUMAN",1,0,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,52,0.78707,null,"12p12.1",{"$nulls":5},"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,null,15813,".","SO:0001583",273,0.8502,0,1,1,0.80357,null,3845,146,5.68,".",1,".",29,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,1.87,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",null,null,1,null,".",0.90707,null,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.67,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,null,null,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,null,0.90789,"NP_203524.1",null,"missense",0.80722,"0.969;0.978",1,"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,17,0,"M","D",".",0.77884,20,42,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,21,null,"Small GTP-binding protein domain (1);",null,"TCGA-F2-6879-01A-11D-2154-08",12,25289551,211,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-2J-AAB8-01","TCGA-2J-AAB8-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",188,18,73,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,185,0.78246,null,"12p12.1","GRCh37",null,0.72,0.72,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.151653,5144,".","SO:0001583",321,0.8502,0,1,1,0.80357,null,3845,36,5.68,".",1,".",4,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-7.94944,1.81,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.56,"d":"5.60E-01"},"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.43,"d":"4.30E-01"},0.305622,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.27,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,0.999983,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.744243,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.2647824,"d":"2.65E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,7,0,"M","D",".",0.77884,69,17,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,73,4,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AAB8-01A-12D-A40W-08",12,25289552,335,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-HZ-A77Q-01","TCGA-HZ-A77Q-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",292,22,72,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,1,28.6,"RASK_HUMAN",1,{"v":0.65,"d":"6.50E-01"},"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,287,0.78246,0,"12p12.1","GRCh37",null,0.53,0.53,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.799347,5144,".","SO:0001583",430,0.8502,0,1,1,0.80357,null,3845,47,5.68,".",1,".",4,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-7.220598,1.89,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.43,"d":"4.30E-01"},"P;P","p.G12R","-",12,1253,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.34,0.129944,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.23,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,72,"Familial Cancer Database",1,0.53,1,0.999999,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.548105,0.90789,"NP_203524.1",0.76,"missense",0.80722,"0.36;0.562",{"v":0.244429,"d":"2.44E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,9,0,"M","D",".",0.77884,71,22,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",6780,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,72,1,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A77Q-01A-11D-A36O-08",12,25289552,369,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-7646-01","TCGA-IB-7646-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",82,22,12,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,82,0.78595,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.071951,15813,".","SO:0001583",404,0.8502,0,1,1,0.80357,null,3845,123,5.68,".",1,".",16,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-16.43694,2.94,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.431058,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.32,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.999248,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9990578,"d":"9.99E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,30,0,"M","D",".",0.77884,12,21,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,12,4,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7646-01A-11D-2154-08",12,25289551,445,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-F2-A44G-01","TCGA-F2-A44G-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",100,17,25,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,99,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.005076,15813,".","SO:0001583",244,0.8502,0,1,1,0.80357,null,3845,29,5.68,".",1,".",14,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-11.08289,1.94,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.79,"d":"7.90E-01"},"B;P","p.G12D","-",12,1323,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.61,0.285858,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.29,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,25,"Familial Cancer Database",1,1,0,0.999976,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.920561,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9093047,"d":"9.09E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,13,0,"M","D",".",0.77884,25,17,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6691,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,25,0,"Small GTP-binding protein domain (1);",null,"TCGA-F2-A44G-01A-11D-A26I-08",12,25289551,183,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-2L-AAQE-01","TCGA-2L-AAQE-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",173,72,79,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,172,0.78595,13,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.09076,15813,".","SO:0001583",271,0.8502,0,1,1,0.80357,null,3845,73,5.68,".",1,".",16,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.81,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",23,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"B;P","p.G12D","-",12,2983,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.9,"d":"9.00E-01"},0.53,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.53,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,8012,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.993266,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9965879,"d":"9.97E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,8,0,"M","D",".",0.77884,79,72,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5037,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,79,2,"Small GTP-binding protein domain (1);",null,"TCGA-2L-AAQE-01A-11D-A397-08",12,25289551,264,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HV-A7OL-01","TCGA-HV-A7OL-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",84,27,15,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,84,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.015189,15813,".","SO:0001583",482,0.8502,0,1,1,0.80357,null,3845,90,5.68,".",1,".",4,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-19.92725,1.92,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"B;P","p.G12D","-",12,1593,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.9,"d":"9.00E-01"},0.365303,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.37,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,15,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.99464,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.684151,"d":"6.84E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,5,0,"M","D",".",0.77884,15,27,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6419,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,15,0,"Small GTP-binding protein domain (1);",null,"TCGA-HV-A7OL-01A-11D-A33T-08",12,25289551,515,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-IB-7887-01","TCGA-IB-7887-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",132,20,23,1,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,128,0.78246,1,"12p12.1","GRCh37",null,0.99,0.99,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,6,2.192614,5144,".","SO:0001583",447,0.8502,0,0,1,0.80357,null,3845,62,5.68,".",1,".",9,{"v":0.9910251,"d":"9.91E-01"},25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-11.31489,1.78,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",627,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.86,"d":"8.60E-01"},"P;P","p.G12R","-",12,653,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,1,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.68,0.314425,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.27,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,23,"Familial Cancer Database",1,1,1,0.659073,1,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",18,0,0.952741,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.1691198,"d":"1.69E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,18,0,"M","D",".",0.77884,23,20,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",7363,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,23,4,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7887-01A-11D-2154-08",12,25289552,365,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-AAUS-01","TCGA-IB-AAUS-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",320,6,108,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,0.49,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,314,0.78595,0,"12p12.1",null,null,0.31,0.31,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.004431,15813,".","SO:0001583",392,0.8502,0,0,1,0.80357,null,3845,7,5.68,".",1,".",2,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-3.383353,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.2,"B;P","p.G12D","-",12,96,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.12,0.13506,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.13,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,108,"Familial Cancer Database",1,0.27,0,0.96329,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.372955,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.0540597,"d":"5.41E-02"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9844467,"d":"9.84E-01"},15,0,"M","D",".",0.77884,108,6,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7936,0.87932,0,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,108,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-AAUS-01A-12D-A38G-08",12,25289551,407,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-M8-A5N4-01","TCGA-M8-A5N4-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",76,7,11,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,23.4,"RASK_HUMAN",1,{"v":0.64,"d":"6.40E-01"},"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,76,0.78595,0,"12p12.1",null,null,0.46,0.46,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.984529,15813,".","SO:0001583",329,0.8502,0,0,1,0.80357,null,3845,60,5.68,".",1,".",4,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-5.741535,1.8,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.32,"d":"3.20E-01"},"B;P","p.G12D","-",12,2198,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.21,0.302388,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.35,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,11,"Familial Cancer Database",1,0.44,0,0.982149,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.487007,0.90789,"NP_203524.1",0.82,"missense",0.80722,"0.257;0.361",{"v":0.2400146,"d":"2.40E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999931,"d":"1.00E+00"},6,0,"M","D",".",0.77884,11,7,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5828,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,11,1,"Small GTP-binding protein domain (1);",null,"TCGA-M8-A5N4-01A-11D-A26I-08",12,25289551,323,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-2J-AABH-01","TCGA-2J-AABH-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",109,26,72,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,107,0.78707,null,"12p12.1",null,null,0.96,0.96,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.364243,15813,".","SO:0001583",407,0.8502,0,1,1,0.80357,null,3845,47,5.68,".",1,".",14,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-17.45493,1.91,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.78,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.64,"d":"6.40E-01"},0.559129,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.49,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.913888,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.9953248,"d":"9.95E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,25,0,"M","D",".",0.77884,72,26,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,72,4,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABH-01A-21D-A40W-08",12,25289551,256,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-IB-A6UF-01","TCGA-IB-A6UF-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",112,67,21,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,97,1,4,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,112,0.78246,0,"12p12.1","GRCh37",null,0.99,0.99,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,3.331817,5144,".","SO:0001583",634,0.8502,0,1,1,0.80357,null,3845,248,5.68,".",1,".",17,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,1.89,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.99,"P;P","p.G12R","-",12,4368,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.744494,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.58,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,21,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.9999426,"d":"1.00E+00"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,12,0,"M","D",".",0.77884,21,67,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",3647,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,21,5,"Small GTP-binding protein domain (1);",null,"TCGA-IB-A6UF-01A-23D-A33T-08",12,25289552,277,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25380275,25380275,"+","missense_variant","Missense_Mutation","SNP","T","T","G","rs17851045",null,"TCGA-HZ-8005-01","TCGA-HZ-8005-10",null,null,"T","G","T","T",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",283,103,77,0,"ENST00000256078.4:c.183A>C","p.Gln61His","p.Q61H","ENST00000256078","NM_033360.2",61,"caA/caC",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.326,0,246,3,1,21.3,"RASK_HUMAN",1,1,"c.183A>C","KRAS_ENST00000557334.1_Intron|AC087239.1_ENST00000594112.1_5'Flank|KRAS_ENST00000311936.3_Missense_Mutation_p.Q61H","-1.81;-1.81","Q",".;RASK_HUMAN","protein_coding",".",".",0.41828,282,0.84146,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:Q61H","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.91146,2,2.016122,153,".","SO:0001583",915,0.43088,0,1,1,0.80357,null,3845,332,5.77,".",1,".",28,1,25349,4.13375,1,0.049057,0.33413,"c.(181-183)caA>caC","D",0.85682,null,null,-20,1.82,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","61;61",2,null,null,0.999,"Substitution - Missense(153)","Mis","T",0.533,1,"-",0.99,"B;B","p.Q61H","-",61,2222,"Noonan syndrome;Cardiofaciocutaneous syndrome","Q61H(CL11_LARGE_INTESTINE)|Q61H(HS766T_PANCREAS)|Q61H(NCIH1155_LUNG)|Q61H(NCIH460_LUNG)|Q61H(T3M4_PANCREAS)",0,0.87265,0,0.6134,"NM_033360.2",3.18,".",".",null,0,"0.0:0.0752:0.0:0.9248",0.98932,0.87829,".","ENST00000311936;ENST00000256078",2,"CAA",3,"D","ENSP00000308495:Q61H;ENSP00000256078:Q61H",5.77,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.327307,1,null,".",0.77662,1,0.9114,1,"UBE2L3/KRAS(2)","H","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.36,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,77,"Familial Cancer Database",1,1,0,1,0,0.423,9.9836,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","TGTACTCCTCTTGACCTGCTG",0,"p.Q61H(153)","ENSG00000133703","yes","L, E, M, O",2,1,0.999998,0.78906,"NP_203524.1",1,"missense",0.80722,"0.092;0.151",{"v":0.9999519,"d":"1.00E+00"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,15,0,"M","D",".",0.6212,77,103,".",".","P01116-2;P01116",0.2643,"P01116",1,"D;D","0.411;0.09",null,"KRAS",5800,0.72032,1,"CCDS8703.1","D",null,0.01,null,2.24,"g.chr12:25380275T>G",null,77,1,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-8005-01A-11D-2201-08",12,25271542,1001,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.32724,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-HZ-8637-01","TCGA-HZ-8637-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",88,11,18,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,27.2,"RASK_HUMAN",1,0.94,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,87,0.78707,null,"12p12.1",null,null,0.81,0.81,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.912163,15813,".","SO:0001583",333,0.8502,0,0,1,0.80357,null,3845,42,5.68,".",1,".",9,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-7.636344,1.85,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.64,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.48,0.111111,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.2,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,0.94,0,{"v":0.9984887,"d":"9.98E-01"},0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.800523,0.90789,"NP_203524.1",0.99,"missense",0.80722,"0.969;0.978",{"v":0.8135095,"d":"8.14E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,18,0,"M","D",".",0.77884,18,10,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,18,1,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-8637-01A-11D-2396-08",12,25289551,383,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-S4-A8RP-01","TCGA-S4-A8RP-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",278,80,46,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,0,28.6,"RASK_HUMAN",1,0.94,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,274,0.78246,0,"12p12.1","GRCh37",null,0.85,0.85,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.002266,5144,".","SO:0001583",355,0.8502,0,1,1,0.80357,null,3845,70,5.68,".",1,".",2,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,1.96,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.76,"P;P","p.G12R","-",12,2314,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.69,0.517491,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.52,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,46,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.856722,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.8213332,"d":"8.21E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,11,0,"M","D",".",0.77884,46,78,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",5714,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,46,0,"Small GTP-binding protein domain (1);",null,"TCGA-S4-A8RP-01A-11D-A36O-08",12,25289552,334,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-AAUQ-01","TCGA-IB-AAUQ-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",186,23,84,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,185,0.78595,null,"12p12.1",null,null,0.87,0.87,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.017306,15813,".","SO:0001583",433,0.8502,0,1,1,0.80357,null,3845,31,5.68,".",1,".",1,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-10.86918,1.93,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.71,"d":"7.10E-01"},"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.58,0.249061,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.25,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",0,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.865459,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.2283932,"d":"2.28E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,7,0,"M","D",".",0.77884,83,23,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,84,1,"Small GTP-binding protein domain (1);",null,"TCGA-IB-AAUQ-01A-22D-A40W-08",12,25289551,303,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-2J-AABR-01","TCGA-2J-AABR-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",215,8,67,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,210,0.78707,null,"12p12.1",null,null,0.79,0.79,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.988592,15813,".","SO:0001583",515,0.8502,0,1,1,0.80357,null,3845,5,5.68,".",1,".",2,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-3.951907,1.97,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.56,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.38,0.080483,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.09,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,0,0.988752,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.78559,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.04051874,"d":"4.05E-02"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9986014,"d":"9.99E-01"},6,0,"M","D",".",0.77884,65,8,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,0,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,67,1,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABR-01A-11D-A40W-08",12,25289551,339,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-FB-AAPZ-01","TCGA-FB-AAPZ-11",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",154,79,76,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,151,0.78246,null,"12p12.1","GRCh37",null,{"v":0.99,"d":"9.90E-01"},{"v":0.99,"d":"9.90E-01"},null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.372814,5144,".","SO:0001583",283,0.8502,0,1,1,0.80357,null,3845,112,5.68,".",1,".",3,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,3.13,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.805589,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.68,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.9803785,"d":"9.80E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,12,0,"M","D",".",0.77884,73,80,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,76,4,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAPZ-01A-11D-A40W-08",12,25289552,196,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-FB-AAQ2-01","TCGA-FB-AAQ2-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",145,63,60,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,4,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,142,0.78595,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.453125,15813,".","SO:0001583",513,0.8502,0,1,1,0.80357,null,3845,140,5.68,".",1,".",11,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.95,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.557667,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.46,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.999999,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9791257,"d":"9.79E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,6,0,"M","D",".",0.77884,59,62,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,60,6,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAQ2-01A-31D-A40W-08",12,25289551,467,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-LB-A9Q5-01","TCGA-LB-A9Q5-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",334,16,81,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,0.5,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,329,0.78595,8,"12p12.1",null,null,0.38,0.38,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,6,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.00347,15813,".","SO:0001583",542,0.8502,0,1,1,0.80357,null,3845,26,5.68,".",1,".",4,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-4.738191,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",17,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.3,"B;P","p.G12D","-",12,607,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.23,0.24182,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.24,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,8005,"Familial Cancer Database",1,0.38,0,0.99993,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.405703,0.90789,"NP_203524.1",0.63,"missense",0.80722,"0.257;0.361",{"v":0.09844747,"d":"9.84E-02"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9993871,"d":"9.99E-01"},7,1,"M","D",".",0.77884,79,16,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7421,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,81,3,"Small GTP-binding protein domain (1);",null,"TCGA-LB-A9Q5-01A-11D-A397-08",12,25289551,469,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-YH-A8SY-01","TCGA-YH-A8SY-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",267,74,76,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,3,98,2,5,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,266,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.58957,15813,".","SO:0001583",316,0.8502,0,1,1,0.80357,null,3845,86,5.68,".",1,".",6,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,3.36,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"D;D","p.G12V","-",12,2275,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.475947,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.22,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,76,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.8377904,"d":"8.38E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,8,0,"M","D",".",0.77884,75,74,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",5743,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,76,8,"Small GTP-binding protein domain (1);",null,"TCGA-YH-A8SY-01A-11D-A377-08",12,25289551,314,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-FB-A4P6-01","TCGA-FB-A4P6-10",{"$nulls":7},"Untested","Somatic","Phase_I","WXS","none",null,null,"Illumina GAIIx",83,0,13,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,null,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,0.58,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,0,0.78707,0,"12p12.1",null,null,0.14,0.14,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,null,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,null,2.006256,15813,".","SO:0001583",219,0.8502,0,null,1,0.80357,null,3845,7,5.68,".",1,".",2,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-2.740795,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.02,"D;D","p.G12V","-",12,177,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0,0.135618,null,null,".",0.90707,0,0.9065,null,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.13,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,13,"Familial Cancer Database",null,0.01,0,null,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",null,null,0.279334,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",null,"D;D","pancreatic, colorectal, lung, thyroid, AML, others",null,7,0,"M","D",".",0.77884,0,0,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",7827,0.72032,null,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,13,3,"Small GTP-binding protein domain (1);",null,"TCGA-FB-A4P6-01A-12D-A26I-08",12,25289551,288,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-2J-AABF-01","TCGA-2J-AABF-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",198,23,52,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,194,0.78595,null,"12p12.1",null,null,0.78,0.78,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.301137,15813,".","SO:0001583",383,0.8502,0,1,1,0.80357,null,3845,40,5.68,".",1,".",8,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-10.40722,1.84,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.63,"d":"6.30E-01"},"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.51,0.394471,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.31,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,1,1,0.999999,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.796552,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9481428,"d":"9.48E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,37,0,"M","D",".",0.77884,51,23,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,52,3,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABF-01A-31D-A40W-08",12,25289551,383,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-3A-A9IX-01","TCGA-3A-A9IX-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",201,6,74,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,199,0.78595,null,"12p12.1",null,null,0.64,0.64,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.001631,15813,".","SO:0001583",264,0.8502,0,1,1,0.80357,null,3845,11,5.68,".",1,".",0,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-3.682514,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.42,"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.26,0.105812,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.1,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",0,1,0,{"v":0.9645832,"d":"9.65E-01"},0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.672448,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.1835716,"d":"1.84E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9946456,"d":"9.95E-01"},23,0,"M","D",".",0.77884,73,6,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,0,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,74,3,"Small GTP-binding protein domain (1);",null,"TCGA-3A-A9IX-01A-11D-A40W-08",12,25289551,335,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-2J-AABI-01","TCGA-2J-AABI-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","RNA",null,null,"Illumina GAIIx",175,262,72,1,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,null,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,97,1,8,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,174,0.78246,null,"12p12.1","GRCh37",null,0.99,0.99,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,null,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,4,4.579651,5144,".","SO:0001583",null,0.8502,0,0,1,0.80357,null,3845,null,5.68,".",1,".",32,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,3.45,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.99,"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.85443,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.54,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,1,1,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",1,"B;P","pancreatic, colorectal, lung, thyroid, AML, others",null,10,null,"M","D",".",0.77884,71,257,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,0,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,72,10,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABI-01A-12D-A40W-08",12,25289552,null,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-A5SP-01","TCGA-IB-A5SP-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",35,49,18,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,34,0.78595,0,"12p12.1",null,null,{"v":0.94,"d":"9.40E-01"},{"v":0.94,"d":"9.40E-01"},null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.532613,15813,".","SO:0001583",1201,0.8502,0,1,1,0.80357,null,3845,105,5.68,".",1,".",11,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.77,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.87,"d":"8.70E-01"},"B;P","p.G12D","-",12,5403,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.79,"d":"7.90E-01"},0.592093,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.74,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,18,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.937091,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.998991,"d":"9.99E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,1,0,"M","D",".",0.77884,18,49,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",2618,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,18,1,"Small GTP-binding protein domain (1);",null,"TCGA-IB-A5SP-01A-11D-A32N-08",12,25289551,109,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-2J-AABO-01","TCGA-2J-AABO-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",169,66,59,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,3,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,168,0.78707,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.055815,15813,".","SO:0001583",212,0.8502,0,1,1,0.80357,null,3845,112,5.68,".",1,".",6,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,3.57,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.387097,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.24,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.7045758,"d":"7.05E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,2,0,"M","D",".",0.77884,59,66,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,59,4,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABO-01A-21D-A40W-08",12,25289551,312,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-XN-A8T5-01","TCGA-XN-A8T5-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",316,13,75,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,311,0.78246,0,"12p12.1","GRCh37",null,0.94,0.94,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.001156,5144,".","SO:0001583",360,0.8502,0,1,1,0.80357,null,3845,9,5.68,".",1,".",2,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-4.124952,2.01,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.69,"P;P","p.G12R","-",12,575,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.51,0.096909,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.09,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,75,"Familial Cancer Database",1,1,0,0.999512,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.876443,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.07858898,"d":"7.86E-02"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9992947,"d":"9.99E-01"},9,0,"M","D",".",0.77884,74,13,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",7447,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,75,3,"Small GTP-binding protein domain (1);",null,"TCGA-XN-A8T5-01A-12D-A36O-08",12,25289552,298,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-3E-AAAZ-01","TCGA-3E-AAAZ-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",306,52,97,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,27.2,"RASK_HUMAN",1,0.84,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,297,0.78707,0,"12p12.1",null,null,0.73,0.73,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.011306,15813,".","SO:0001583",369,0.8502,0,1,1,0.80357,null,3845,38,5.68,".",1,".",7,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-19.99995,1.81,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.64,"D;D","p.G12V","-",12,2010,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.56,0.360561,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.38,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,97,"Familial Cancer Database",1,0.74,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.747354,0.90789,"NP_203524.1",0.93,"missense",0.80722,"0.969;0.978",{"v":0.8929242,"d":"8.93E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,18,0,"M","D",".",0.77884,97,51,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",6000,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,97,0,"Small GTP-binding protein domain (1);",null,"TCGA-3E-AAAZ-01A-11D-A38G-08",12,25289551,274,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-2L-AAQI-01","TCGA-2L-AAQI-11",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",272,34,56,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,0.98,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,271,0.78707,4,"12p12.1",null,null,0.79,0.79,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.119234,15813,".","SO:0001583",173,0.8502,0,1,1,0.80357,null,3845,43,5.68,".",1,".",10,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-13.94277,1.81,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",12,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.66,"D;D","p.G12V","-",12,1230,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.56,"d":"5.60E-01"},0.302143,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.29,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,8006,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.808335,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.7633422,"d":"7.63E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,14,0,"M","D",".",0.77884,56,34,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",6776,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,56,3,"Small GTP-binding protein domain (1);",null,"TCGA-2L-AAQI-01A-12D-A397-08",12,25289551,379,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-FB-AAQ1-01","TCGA-FB-AAQ1-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",157,40,57,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,156,0.78595,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.103429,15813,".","SO:0001583",235,0.8502,0,1,1,0.80357,null,3845,50,5.68,".",1,".",1,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.75,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.9,"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.77,"d":"7.70E-01"},0.391187,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.39,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",0,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.964208,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.4382169,"d":"4.38E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,6,0,"M","D",".",0.77884,57,39,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,57,3,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAQ1-01A-12D-A40W-08",12,25289551,304,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-S4-A8RO-01","TCGA-S4-A8RO-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",177,79,51,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,173,0.78595,0,"12p12.1",null,null,0.91,0.91,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.002208,15813,".","SO:0001583",696,0.8502,0,1,1,0.80357,null,3845,118,5.68,".",1,".",6,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,2.08,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.83,"d":"8.30E-01"},"B;P","p.G12D","-",12,3068,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.75,"d":"7.50E-01"},0.684294,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.68,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,51,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.916249,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9959214,"d":"9.96E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,16,0,"M","D",".",0.77884,51,78,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",4964,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,51,3,"Small GTP-binding protein domain (1);",null,"TCGA-S4-A8RO-01A-12D-A377-08",12,25289551,342,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398282,25398282,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913535",null,"TCGA-FB-A78T-01","TCGA-FB-A78T-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",82,14,20,0,"ENST00000256078.4:c.37G>T","p.Gly13Cys","p.G13C","ENST00000256078","NM_033360.2",13,"Ggc/Tgc",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,100,1,0,25.9,"RASK_HUMAN",1,0.67,"c.37G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G13C|KRAS_ENST00000557334.1_Missense_Mutation_p.G13C|KRAS_ENST00000311936.3_Missense_Mutation_p.G13C","-1.76;-0.81;-0.81;-0.81","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,81,0.83755,0,"12p12.1",null,null,0.53,0.53,null,"ENSP00000256078:G13C","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.002479,321,".","SO:0001583",204,0.8502,0,1,1,0.80357,null,3845,65,5.68,".",0,".",7,1,25349,4.686065,1,0,0.89917,"c.(37-39)Ggc>Tgc","D",0.85682,null,null,-3.36633,1.94,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","13;13",2,null,null,0.998,"Substitution - Missense(317)|Insertion - In frame(4)","Mis","C",0.563,1,"-",0.41,"D;D","p.G13C","-",13,2435,"Noonan syndrome;Cardiofaciocutaneous syndrome","G13C(MORCPR_LUNG)|G13C(NCIH1355_LUNG)|G13C(NCIH1734_LUNG)|G13C(TOV21G_OVARY)",0,0.9274,0,0.7692,"NM_033360.2",2.97,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.93619,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGC",2,"D","ENSP00000308495:G13C;ENSP00000452512:G13C;ENSP00000256078:G13C;ENSP00000451856:G13C",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.31,"d":"3.10E-01"},0.544995,0,null,".",0.88639,0,0.8864,1,"UBE2L3/KRAS(2)","C","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.55,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,20,"Familial Cancer Database",1,0.51,0,0.999819,0,0.343,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","TTGCCTACGCCACCAGCTCCA",0,"p.G13C(213)|p.G13S(59)|p.G13R(43)|p.G12_G13insG(3)|p.G13N(1)|p.G13I(1)|p.G12_G13insA(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.545668,0.90789,"NP_203524.1",0.8,"missense",0.80722,"0.981;0.997",{"v":0.8740183,"d":"8.74E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,17,0,"M","D",".",0.77884,20,14,".",".","P01116-2;P01116",0.6946,"P01116",1,"D;T;T;T","1.0;1.0",null,"KRAS",5585,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398282C>A",null,20,0,"Small GTP-binding protein domain (1);",null,"TCGA-FB-A78T-01A-12D-A32N-08",12,25289549,283,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.8513,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-IB-AAUO-01","TCGA-IB-AAUO-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",227,51,107,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,221,0.78595,0,"12p12.1",null,null,0.93,0.93,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.013098,15813,".","SO:0001583",333,0.8502,0,1,1,0.80357,null,3845,59,5.68,".",1,".",2,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.86,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.82,"B;P","p.G12D","-",12,1697,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.72,0.365534,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.38,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,107,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.922427,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.4524297,"d":"4.52E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,6,0,"M","D",".",0.77884,107,50,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6340,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,107,0,"Small GTP-binding protein domain (1);",null,"TCGA-IB-AAUO-01A-12D-A38G-08",12,25289551,312,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-2L-AAQA-01","TCGA-2L-AAQA-11",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",239,101,129,1,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,236,0.78707,1,"12p12.1",null,null,0.95,0.95,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,4,2.008629,15813,".","SO:0001583",178,0.8502,0,1,1,0.80357,null,3845,68,5.68,".",1,".",28,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,1.89,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",146,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.87,"d":"8.70E-01"},"D;D","p.G12V","-",12,2498,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.8,"d":"8.00E-01"},0.587629,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.6,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,129,"Familial Cancer Database",1,1,0,1,1,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.945562,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.9999856,"d":"1.00E+00"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,29,0,"M","D",".",0.77884,128,101,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",5510,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,129,0,"Small GTP-binding protein domain (1);",null,"TCGA-2L-AAQA-01A-21D-A38G-08",12,25289551,251,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25380275,25380275,"+","missense_variant","Missense_Mutation","SNP","T","T","G","rs17851045",null,"TCGA-IB-7649-01","TCGA-IB-7649-10",null,null,"T","G","T","T",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",382,36,49,0,"ENST00000256078.4:c.183A>C","p.Gln61His","p.Q61H","ENST00000256078","NM_033360.2",61,"caA/caC",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.326,0,246,3,1,21.3,"RASK_HUMAN",1,1,"c.183A>C","KRAS_ENST00000557334.1_Intron|AC087239.1_ENST00000594112.1_5'Flank|KRAS_ENST00000311936.3_Missense_Mutation_p.Q61H","-1.81;-1.81","Q",".;RASK_HUMAN","protein_coding",".",".",0.41828,379,0.84146,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:Q61H","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.91146,2,2.003622,153,".","SO:0001583",732,0.43088,0,1,1,0.80357,null,3845,45,5.77,".",1,".",5,null,25349,4.13375,null,0.049057,0.33413,"c.(181-183)caA>caC","D",0.85682,null,null,-20,1.97,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","61;61",{"$nulls":3},0.999,"Substitution - Missense(153)","Mis","T",0.533,1,"-",0.9,"B;B","p.Q61H","-",61,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","Q61H(CL11_LARGE_INTESTINE)|Q61H(HS766T_PANCREAS)|Q61H(NCIH1155_LUNG)|Q61H(NCIH460_LUNG)|Q61H(T3M4_PANCREAS)",0,0.87265,0,0.6134,"NM_033360.2",3.18,".",".",null,0,"0.0:0.0752:0.0:0.9248",0.98932,0.87829,".","ENST00000311936;ENST00000256078",2,"CAA",3,"D","ENSP00000308495:Q61H;ENSP00000256078:Q61H",5.77,"OTTHUMT00000412232.1","KNOWN",".",0.76,0.155949,1,null,".",0.77662,1,0.9114,1,"UBE2L3/KRAS(2)","H","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.16,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,0,1,0,0.423,9.9836,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","TGTACTCCTCTTGACCTGCTG",0,"p.Q61H(153)","ENSG00000133703","yes","L, E, M, O",2,0,0.967083,0.78906,"NP_203524.1",1,"missense",0.80722,"0.092;0.151",{"v":0.6719822,"d":"6.72E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,21,0,"M","D",".",0.6212,49,36,".",".","P01116-2;P01116",0.2643,"P01116",1,"D;D","0.411;0.09",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,2.24,"g.chr12:25380275T>G",null,49,1,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7649-01A-11D-2154-08",12,25271542,388,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.32724,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-2J-AAB9-01","TCGA-2J-AAB9-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",204,8,59,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,202,0.78595,null,"12p12.1",null,null,0.9,0.9,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.100239,15813,".","SO:0001583",297,0.8502,0,1,1,0.80357,null,3845,11,5.68,".",1,".",0,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-4.033993,2.02,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.6,"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.4,0.127907,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.1,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",0,1,0,0.989367,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.835757,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.01764996,"d":"1.76E-02"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.997892,"d":"9.98E-01"},5,0,"M","D",".",0.77884,57,8,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,0,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,59,3,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AAB9-01A-11D-A40W-08",12,25289551,289,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HZ-A4BH-01","TCGA-HZ-A4BH-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",90,21,10,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,23.4,"RASK_HUMAN",1,{"v":0.97,"d":"9.70E-01"},"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,89,0.78595,null,"12p12.1",null,null,0.87,0.87,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.717647,15813,".","SO:0001583",389,0.8502,0,0,1,0.80357,null,3845,28,5.68,".",1,".",11,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-14.88431,1.82,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.75,"d":"7.50E-01"},"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.62,0.183432,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.31,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",1,0.99,1,0.999999,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.862398,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.8023678,"d":"8.02E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,4,0,"M","D",".",0.77884,10,21,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,10,1,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A4BH-01A-11D-A26I-08",12,25289551,131,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-XD-AAUG-01","TCGA-XD-AAUG-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",181,8,69,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,178,0.78707,null,"12p12.1",null,null,0.77,0.77,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.998467,15813,".","SO:0001583",277,{"v":0.8502,"d":"8.50E-01"},0,1,1,0.80357,null,3845,21,5.68,".",1,".",2,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-4.23915,1.91,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.54,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.37,0.102596,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.11,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,0,0.988903,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.769969,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.09641019,"d":"9.64E-02"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9997017,"d":"1.00E+00"},7,0,"M","D",".",0.77884,69,7,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,69,1,"Small GTP-binding protein domain (1);",null,"TCGA-XD-AAUG-01A-61D-A40W-08",12,25289551,354,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-OE-A75W-01","TCGA-OE-A75W-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",63,30,18,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,63,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.051268,15813,".","SO:0001583",304,0.8502,0,1,1,0.80357,null,3845,67,5.68,".",1,".",6,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.77,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.92,"d":"9.20E-01"},"B;P","p.G12D","-",12,2553,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.78,"d":"7.80E-01"},0.55213,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.57,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,18,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.972074,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9601079,"d":"9.60E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,8,0,"M","D",".",0.77884,18,30,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5469,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,18,0,"Small GTP-binding protein domain (1);",null,"TCGA-OE-A75W-01A-12D-A32N-08",12,25289551,264,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-HZ-A77O-01","TCGA-HZ-A77O-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",110,27,11,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,110,0.78707,0,"12p12.1",null,null,0.9,0.9,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.439058,15813,".","SO:0001583",432,0.8502,0,0,1,0.80357,null,3845,103,5.68,".",1,".",7,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-18.1988,1.61,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.74,"D;D","p.G12V","-",12,2103,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.61,0.545455,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.5,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,11,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.882752,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.8185388,"d":"8.19E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,8,0,"M","D",".",0.77884,11,27,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",5919,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,11,4,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A77O-01A-11D-A33T-08",12,25289551,448,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25380275,25380275,"+","missense_variant","Missense_Mutation","SNP","T","T","A","rs17851045",null,"TCGA-HZ-7922-01","TCGA-HZ-7922-10",null,null,"T","A","T","T",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",285,185,47,0,"ENST00000256078.4:c.183A>T","p.Gln61His","p.Q61H","ENST00000256078","NM_033360.2",61,"caA/caT",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.326,null,246,3,null,22.1,"RASK_HUMAN",1,0,"c.183A>T","KRAS_ENST00000557334.1_Intron|AC087239.1_ENST00000594112.1_5'Flank|KRAS_ENST00000311936.3_Missense_Mutation_p.Q61H","-1.81;-1.81","Q",".;RASK_HUMAN","protein_coding",".",".",0.41828,284,0.84146,null,"12p12.1",{"$nulls":5},"ENSP00000256078:Q61H","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,8,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.91146,2,null,153,".","SO:0001583",864,0.43088,0,1,1,0.80357,null,3845,513,5.77,".",1,".",56,null,25349,4.243092,null,0.049057,0.33413,"c.(181-183)caA>caT","D",0.85682,null,null,-20,2.95,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","61;61",{"$nulls":3},{"v":0.999,"d":"9.99E-01"},"Substitution - Missense(153)","Mis","T",0.533,1,"-",0,"B;B","p.Q61H","-",61,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","Q61H(CL11_LARGE_INTESTINE)|Q61H(HS766T_PANCREAS)|Q61H(NCIH1155_LUNG)|Q61H(NCIH460_LUNG)|Q61H(T3M4_PANCREAS)",0,0.87265,0,0.6134,"NM_033360.2",3.18,".",".",null,0,"0.0:0.0752:0.0:0.9248",0.98932,0.87829,".","ENST00000311936;ENST00000256078",2,"CAA",3,"D","ENSP00000308495:Q61H;ENSP00000256078:Q61H",5.77,"OTTHUMT00000412232.1","KNOWN","rs17851045",null,null,1,null,".",0.79912,null,0.9114,1,"UBE2L3/KRAS(2)","H","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.37,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,null,null,1,0,0.423,9.9836,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","TGTACTCCTCTTGACCTGCTG",0,"p.Q61H(153)","ENSG00000133703","yes","L, E, M, O",2,1,null,0.78906,"NP_203524.1",null,"missense",0.80722,"0.092;0.151",1,"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,64,1,"M","D",".",0.6212,47,184,".",".","P01116-2;P01116",0.2643,"P01116",1,"D;D","0.411;0.09",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,2.24,"g.chr12:25380275T>A",null,47,null,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-7922-01A-11D-2154-08",12,25271542,1006,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.32724,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-FB-AAQ0-01","TCGA-FB-AAQ0-11",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",147,54,62,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,1,28.6,"RASK_HUMAN",1,{"v":0.84,"d":"8.40E-01"},"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,147,0.78246,null,"12p12.1","GRCh37",null,0.74,0.74,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.030175,5144,".","SO:0001583",204,0.8502,0,1,1,0.80357,null,3845,103,5.68,".",1,".",10,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,1.88,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",{"v":0.998,"d":"9.98E-01"},"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.66,"d":"6.60E-01"},"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.58,"d":"5.80E-01"},0.648824,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.67,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,0.75,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.757835,0.90789,"NP_203524.1",0.92,"missense",0.80722,"0.36;0.562",{"v":0.9691807,"d":"9.69E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,8,0,"M","D",".",0.77884,60,53,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,62,1,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAQ0-01A-31D-A40W-08",12,25289552,226,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-3A-A9IU-01","TCGA-3A-A9IU-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",223,72,38,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,0.91,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,223,0.78595,10,"12p12.1",null,null,0.81,0.81,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.002191,15813,".","SO:0001583",198,0.8502,0,1,1,0.80357,null,3845,85,5.68,".",1,".",10,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.91,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",19,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.73,"d":"7.30E-01"},"B;P","p.G12D","-",12,2786,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.66,"d":"6.60E-01"},0.570025,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.58,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,8009,"Familial Cancer Database",1,0.82,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.825014,0.90789,"NP_203524.1",0.98,"missense",0.80722,"0.257;0.361",{"v":0.9901401,"d":"9.90E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,14,0,"M","D",".",0.77884,38,71,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5228,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,38,0,"Small GTP-binding protein domain (1);",null,"TCGA-3A-A9IU-01A-11D-A397-08",12,25289551,245,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-RB-AA9M-01","TCGA-RB-AA9M-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",311,18,31,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,308,0.78707,2,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.02418,15813,".","SO:0001583",770,0.8502,0,1,1,0.80357,null,3845,11,5.68,".",1,".",9,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-5.560625,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",17,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.91,"D;D","p.G12V","-",12,617,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.7,0.111112,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.100001,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,7998,"Familial Cancer Database",1,1,0,0.999982,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.964314,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.4935802,"d":"4.94E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999959,"d":"1.00E+00"},20,0,"M","D",".",0.77884,31,18,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",7400,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,31,3,"Small GTP-binding protein domain (1);",null,"TCGA-RB-AA9M-01A-11D-A397-08",12,25289551,369,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HZ-7926-01","TCGA-HZ-7926-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",108,15,27,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,107,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.049554,15813,".","SO:0001583",353,0.8502,0,1,1,0.80357,null,3845,55,5.68,".",1,".",10,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-9.284926,1.88,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"B;P","p.G12D","-",12,1284,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.92,0.169304,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.16,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,27,"Familial Cancer Database",1,1,0,0.999901,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.995235,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.987975,"d":"9.88E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,46,0,"M","D",".",0.77884,27,15,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6745,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,27,3,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-7926-01A-11D-2154-08",12,25289551,498,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-FB-AAPU-01","TCGA-FB-AAPU-11",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",89,47,48,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,89,0.78246,null,"12p12.1","GRCh37",null,0.98,0.98,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.011295,5144,".","SO:0001583",642,0.8502,0,1,1,0.80357,null,3845,90,5.68,".",1,".",45,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.87,"d":"8.70E-01"},"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.76,"d":"7.60E-01"},0.701046,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.7,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.950762,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",1,"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,31,0,"M","D",".",0.77884,48,47,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,48,3,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAPU-01A-31D-A40W-08",12,25289552,246,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-HV-AA8V-01","TCGA-HV-AA8V-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",172,18,81,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,172,0.78707,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.994619,15813,".","SO:0001583",522,0.8502,0,1,1,0.80357,null,3845,23,5.68,".",1,".",4,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-8.544739,3.86,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.97,0.183099,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.13,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,0,0.999986,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.997089,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.1147111,"d":"1.15E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,2,0,"M","D",".",0.77884,81,18,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,81,3,"Small GTP-binding protein domain (1);",null,"TCGA-HV-AA8V-01A-11D-A40W-08",12,25289551,595,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-IB-AAUR-01","TCGA-IB-AAUR-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",355,15,145,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,97,1,2,28.6,"RASK_HUMAN",1,0.62,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,351,0.78246,0,"12p12.1","GRCh37",null,0.46,0.46,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.001217,5144,".","SO:0001583",315,0.8502,0,1,1,0.80357,null,3845,12,5.68,".",1,".",6,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-4.237758,2.01,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.35,"P;P","p.G12R","-",12,393,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.27,0.185134,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.18,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,145,"Familial Cancer Database",1,0.44,0,0.999868,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.504453,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.1517387,"d":"1.52E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999763,"d":"1.00E+00"},10,0,"M","D",".",0.77884,145,15,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",7627,0.66056,0,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,145,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-AAUR-01A-21D-A38G-08",12,25289552,441,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-2L-AAQJ-01","TCGA-2L-AAQJ-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",181,55,58,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,23.4,"RASK_HUMAN",1,{"v":0.91,"d":"9.10E-01"},"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,181,0.78595,14,"12p12.1",null,null,0.81,0.81,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.726764,15813,".","SO:0001583",208,0.8502,0,1,1,0.80357,null,3845,56,5.68,".",1,".",22,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,1.87,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",25,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.72,"d":"7.20E-01"},"B;P","p.G12D","-",12,2326,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.63,0.282051,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.44,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,7988,"Familial Cancer Database",1,0.82,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.81658,0.90789,"NP_203524.1",0.97,"missense",0.80722,"0.257;0.361",{"v":0.9792503,"d":"9.79E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,1,0,"M","D",".",0.77884,57,55,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5689,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,58,1,"Small GTP-binding protein domain (1);",null,"TCGA-2L-AAQJ-01A-12D-A397-08",12,25289551,211,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-3A-A9IH-01","TCGA-3A-A9IH-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",237,46,64,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,null,97,1,null,28.6,"RASK_HUMAN",1,0,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,236,0.78246,5,"12p12.1","GRCh37",{"$nulls":4},"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,null,5144,".","SO:0001583",223,0.8502,0,1,1,0.80357,null,3845,42,5.68,".",1,".",16,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-19.99992,1.83,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",21,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0,"P;P","p.G12R","-",12,2550,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",null,null,1,null,".",0.92389,null,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.51,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,8002,"Familial Cancer Database",1,null,null,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,null,0.90789,"NP_203524.1",null,"missense",0.80722,"0.36;0.562",{"v":0.9674765,"d":"9.67E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,15,0,"M","D",".",0.77884,64,44,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",5470,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,64,null,"Small GTP-binding protein domain (1);",null,"TCGA-3A-A9IH-01A-12D-A397-08",12,25289552,203,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-2J-AAB4-01","TCGA-2J-AAB4-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",165,18,67,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,164,0.78707,null,"12p12.1",null,null,0.72,0.72,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.894994,15813,".","SO:0001583",343,0.8502,0,1,1,0.80357,null,3845,28,5.68,".",1,".",9,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-8.782162,1.95,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.55,"d":"5.50E-01"},"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.42,"d":"4.20E-01"},0.3,1,null,".",0.90707,0,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.3,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,0.65,1,0.999986,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.752612,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.5240795,"d":"5.24E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999992,"d":"1.00E+00"},8,0,"M","D",".",0.77884,67,18,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,67,2,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AAB4-01A-12D-A40W-08",12,25289551,215,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-2J-AAB6-01","TCGA-2J-AAB6-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",90,101,82,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,4,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,90,0.78707,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.493078,15813,".","SO:0001583",412,0.8502,0,1,1,0.80357,null,3845,178,5.68,".",1,".",7,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,2.4,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.679978,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.54,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.9855492,"d":"9.86E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,2,0,"M","D",".",0.77884,81,101,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,82,4,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AAB6-01A-11D-A40W-08",12,25289551,157,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-HZ-A9TJ-01","TCGA-HZ-A9TJ-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",189,64,69,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,3,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,188,0.78707,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.618221,15813,".","SO:0001583",379,0.8502,0,1,1,0.80357,null,3845,181,5.68,".",1,".",12,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-20,3.45,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.730337,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.52,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.9968643,"d":"9.97E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,17,0,"M","D",".",0.77884,66,64,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,69,5,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-A9TJ-01A-11D-A40W-08",12,25289551,568,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HV-A5A3-01","TCGA-HV-A5A3-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",52,54,13,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,4,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,51,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.243856,15813,".","SO:0001583",466,0.8502,0,0,1,0.80357,null,3845,242,5.68,".",1,".",9,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,2.04,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"B;P","p.G12D","-",12,4030,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.656145,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.61,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,13,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.9998535,"d":"1.00E+00"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,9,0,"M","D",".",0.77884,13,54,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",3985,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,13,4,"Small GTP-binding protein domain (1);",null,"TCGA-HV-A5A3-01A-11D-A26I-08",12,25289551,345,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
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[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-FB-AAQ3-01","TCGA-FB-AAQ3-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",186,30,83,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,0.84,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,185,0.78595,null,"12p12.1",null,null,0.71,0.71,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.994408,15813,".","SO:0001583",434,0.8502,0,1,1,0.80357,null,3845,83,5.68,".",1,".",0,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-15.36549,1.89,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.59,"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.49,"d":"4.90E-01"},0.363057,1,null,".",0.8334,0,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.38,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",0,0.71,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.721819,0.90789,"NP_203524.1",0.95,"missense",0.80722,"0.257;0.361",0,"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,1,0,"M","D",".",0.77884,81,30,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,83,0,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAQ3-01A-11D-A40W-08",12,25289551,490,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-HZ-8636-01","TCGA-HZ-8636-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",75,29,9,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,2,98,2,4,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,74,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.641319,15813,".","SO:0001583",9,0.8502,0,1,1,0.80357,null,3845,124,5.68,".",1,".",31,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-19.99992,1.67,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"D;D","p.G12V","-",12,2968,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.520169,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.41,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,9,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.999914,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.9999982,"d":"1.00E+00"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,32,0,"M","D",".",0.77884,8,29,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",5046,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,9,6,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-8636-01A-21D-2396-08",12,25289551,360,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HZ-8315-01","TCGA-HZ-8315-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",73,11,15,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,73,0.78595,0,"12p12.1",null,null,0.96,0.96,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.005592,15813,".","SO:0001583",373,0.8502,0,0,1,0.80357,null,3845,61,5.68,".",1,".",8,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-8.35852,1.94,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.72,"d":"7.20E-01"},"B;P","p.G12D","-",12,1433,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.53,0.266037,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.27,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,15,"Familial Cancer Database",1,1,0,0.99871,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.892294,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.8437386,"d":"8.44E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,17,0,"M","D",".",0.77884,15,11,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",6444,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,15,0,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-8315-01A-11D-2396-08",12,25289551,485,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-US-A77G-01","TCGA-US-A77G-11",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",93,19,17,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,0,28.6,"RASK_HUMAN",1,{"v":0.98,"d":"9.80E-01"},"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,93,0.78246,0,"12p12.1","GRCh37",null,0.8,0.8,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.056247,5144,".","SO:0001583",340,0.8502,0,1,1,0.80357,null,3845,56,5.68,".",1,".",14,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-12.94714,1.87,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.65,"d":"6.50E-01"},"P;P","p.G12R","-",12,1940,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.51,"d":"5.10E-01"},0.42,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.42,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,17,"Familial Cancer Database",1,1,0,0.999995,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.81055,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.9685956,"d":"9.69E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,17,0,"M","D",".",0.77884,17,19,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",6087,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,17,0,"Small GTP-binding protein domain (1);",null,"TCGA-US-A77G-01A-11D-A32N-08",12,25289552,255,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-US-A779-01","TCGA-US-A779-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",73,25,19,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,73,0.78595,0,"12p12.1",null,null,0.86,0.86,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.018561,15813,".","SO:0001583",322,0.8502,0,1,1,0.80357,null,3845,57,5.68,".",1,".",5,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-19.75805,1.86,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.72,"d":"7.20E-01"},"B;P","p.G12D","-",12,2553,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.59,"d":"5.90E-01"},0.554773,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.57,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,19,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.856843,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.7642343,"d":"7.64E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,5,0,"M","D",".",0.77884,19,25,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5479,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,19,0,"Small GTP-binding protein domain (1);",null,"TCGA-US-A779-01A-11D-A32N-08",12,25289551,193,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-IB-7889-01","TCGA-IB-7889-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",72,13,17,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,3,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,72,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.089326,15813,".","SO:0001583",403,0.8502,0,1,1,0.80357,null,3845,8,5.68,".",1,".",3,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-9.865792,1.9,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"D;D","p.G12V","-",12,1878,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.87,0.25366,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.22,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,17,"Familial Cancer Database",1,1,1,0.999679,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.992446,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.127922,"d":"1.28E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9996229,"d":"1.00E+00"},1,0,"M","D",".",0.77884,17,13,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",6141,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,17,3,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7889-01A-11D-2154-08",12,25289551,75,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-IB-7645-01","TCGA-IB-7645-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",116,14,18,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,0,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,115,0.78707,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.977355,15813,".","SO:0001583",400,0.8502,0,0,1,0.80357,null,3845,28,5.68,".",1,".",19,1,25349,4.808637,1,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-8.307574,1.99,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"D;D","p.G12V","-",12,324,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.84,0.125305,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.14,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,18,"Familial Cancer Database",1,1,0,0.999789,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.990287,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.9463491,"d":"9.46E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,25,0,"M","D",".",0.77884,18,13,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",7698,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,18,0,"Small GTP-binding protein domain (1);",null,"TCGA-IB-7645-01A-22D-2201-08",12,25289551,581,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-RB-A7B8-01","TCGA-RB-A7B8-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",100,11,11,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,96,0.78246,0,"12p12.1","GRCh37",null,0.77,0.77,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.990823,5144,".","SO:0001583",285,0.8502,0,0,1,0.80357,null,3845,41,5.68,".",1,".",4,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-7.059248,2.18,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.57,"P;P","p.G12R","-",12,1667,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.41,"d":"4.10E-01"},0.278763,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.27,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,11,"Familial Cancer Database",1,1,0,{"v":0.9982984,"d":"9.98E-01"},0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.775878,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.4031158,"d":"4.03E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999997,"d":"1.00E+00"},8,0,"M","D",".",0.77884,11,11,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",6368,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,11,3,"Small GTP-binding protein domain (1);",null,"TCGA-RB-A7B8-01A-12D-A33T-08",12,25289552,302,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","A","rs121913529",null,"TCGA-XD-AAUI-01","TCGA-XD-AAUI-10",null,null,"C","A","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",155,22,56,0,"ENST00000256078.4:c.35G>T","p.Gly12Val","p.G12V","ENST00000256078","NM_033360.2",12,"gGt/gTt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,27.2,"RASK_HUMAN",1,1,"c.35G>T","KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V","-1.2;-1.2;-1.2;-1.2","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,154,0.78707,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12V","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.030377,15813,".","SO:0001583",361,0.8502,0,1,1,0.80357,null,3845,41,5.68,".",1,".",1,null,25349,4.808637,null,0,0.76494,"c.(34-36)gGt>gTt","D",0.85682,null,null,-11.59772,1.91,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",{"v":0.98,"d":"9.80E-01"},"D;D","p.G12V","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",0,0.90373,0,0.6987,"NM_033360.2",3.135,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.91773,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.79,0.217396,1,null,".",0.90707,1,0.9065,1,"UBE2L3/KRAS(2)","V","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.21,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",0,1,0,0.999999,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.981165,0.90789,"NP_203524.1",1,"missense",0.80722,"0.969;0.978",{"v":0.505554,"d":"5.06E-01"},"D;D","pancreatic, colorectal, lung, thyroid, AML, others",1,5,0,"M","D",".",0.77884,52,22,".",".","P01116-2;P01116",0.5429,"P01116",1,"T;T;T;T","0.997;0.999",null,"KRAS",null,0.72032,1,"CCDS8703.1","D",null,0.01,null,7.743,"g.chr12:25398284C>A",null,56,3,"Small GTP-binding protein domain (1);",null,"TCGA-XD-AAUI-01A-42D-A40W-08",12,25289551,401,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.72625,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HZ-8519-01","TCGA-HZ-8519-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",92,5,18,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,91,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.008547,15813,".","SO:0001583",358,0.8502,0,null,1,0.80357,null,3845,7,5.68,".",1,".",6,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-4.444013,2.02,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,{"v":0.998,"d":"9.98E-01"},"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.79,"B;P","p.G12D","-",12,208,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.48,0.098519,null,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.09,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,18,"Familial Cancer Database",1,1,0,0.937536,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,null,0.927638,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.5926294,"d":"5.93E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999648,"d":"1.00E+00"},29,0,"M","D",".",0.77884,18,5,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7817,0.87932,null,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,18,3,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-8519-01A-11D-2396-08",12,25289551,613,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-XN-A8T3-01","TCGA-XN-A8T3-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",305,79,73,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,3,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,299,0.78595,0,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.014333,15813,".","SO:0001583",327,0.8502,0,1,1,0.80357,null,3845,64,5.68,".",1,".",4,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-20,3.53,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.99,"B;P","p.G12D","-",12,2417,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.99,0.306032,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.19,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,73,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,1,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.6393962,"d":"6.39E-01"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",1,6,0,"M","D",".",0.77884,73,77,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",5606,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,73,4,"Small GTP-binding protein domain (1);",null,"TCGA-XN-A8T3-01A-11D-A36O-08",12,25289551,277,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-F2-A8YN-01","TCGA-F2-A8YN-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",132,72,53,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,131,0.78246,0,"12p12.1","GRCh37",null,0.99,0.99,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.831904,5144,".","SO:0001583",309,0.8502,0,1,1,0.80357,null,3845,76,5.68,".",1,".",26,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-20,1.8,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.99,"d":"9.90E-01"},"P;P","p.G12R","-",12,2839,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",{"v":0.99,"d":"9.90E-01"},0.57,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.57,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,53,"Familial Cancer Database",1,1,1,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,1,0.999472,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.9999185,"d":"1.00E+00"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",1,4,0,"M","D",".",0.77884,53,69,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",5174,0.66056,1,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,53,2,"Small GTP-binding protein domain (1);",null,"TCGA-F2-A8YN-01A-11D-A377-08",12,25289552,171,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-HZ-8003-01","TCGA-HZ-8003-10",null,null,"C","G","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",186,8,18,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,97,1,1,28.6,"RASK_HUMAN",1,0.72,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,181,0.78246,0,"12p12.1","GRCh37",null,0.52,0.52,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.992052,5144,".","SO:0001583",434,0.8502,0,0,1,0.80357,null,3845,18,5.68,".",1,".",4,1,25349,4.930538,1,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-4.093351,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",2,null,"KRAS",{"v":0.998,"d":"9.98E-01"},"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",0.37,"P;P","p.G12R","-",12,331,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.25,0.15527,1,null,".",0.92389,0,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.16,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,18,"Familial Cancer Database",1,0.5,0,{"v":0.9886745,"d":"9.89E-01"},0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.553278,0.90789,"NP_203524.1",0.92,"missense",0.80722,"0.36;0.562",{"v":0.3309613,"d":"3.31E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999589,"d":"1.00E+00"},22,0,"M","D",".",0.77884,17,8,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",7683,0.66056,0,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,18,1,"Small GTP-binding protein domain (1);",null,"TCGA-HZ-8003-01A-21D-2201-08",12,25289552,530,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398285,25398285,"+","missense_variant","Missense_Mutation","SNP","C","C","G","rs121913530",null,"TCGA-2J-AABT-01","TCGA-2J-AABT-10",{"$nulls":7},"Untested","Somatic","Phase_I","WXS","none",null,null,"Illumina GAIIx",173,24,128,0,"ENST00000256078.4:c.34G>C","p.Gly12Arg","p.G12R","ENST00000256078","NM_033360.2",12,"Ggt/Cgt",0,null,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,97,1,2,28.6,"RASK_HUMAN",1,1,"c.34G>C","KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000311936.3_Missense_Mutation_p.G12R","-1.16;-1.16;-1.16;-1.16","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,170,0.78246,null,"12p12.1","GRCh37",null,0.97,0.97,null,"ENSP00000256078:G12R","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,null,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.995188,5144,".","SO:0001583",null,0.8502,0,0,1,0.80357,null,3845,null,5.68,".",1,".",2,null,25349,4.930538,null,0,0.43287,"c.(34-36)Ggt>Cgt","D",0.85682,null,"M",-11.94446,2.02,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",null,null,"KRAS",0.998,"Substitution - Missense(5142)|Insertion - In frame(2)","Mis","C",0.563,1,"-",{"v":0.8,"d":"8.00E-01"},"P;P","p.G12R","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)",0,0.84893,0,0.5573,"NM_033360.2",2.675,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.86658,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12R;ENSP00000452512:G12R;ENSP00000256078:G12R;ENSP00000451856:G12R",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.65,0.250936,1,null,".",0.92389,1,0.84082,1,"UBE2L3/KRAS(2)","R","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.25,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",null,null,"Familial Cancer Database",1,1,0,1,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","CCTACGCCACCAGCTCCAACT",0,"p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.921768,0.90789,"NP_203524.1",1,"missense",0.80722,"0.36;0.562",{"v":0.6320314,"d":"6.32E-01"},"B;P","pancreatic, colorectal, lung, thyroid, AML, others",null,15,null,"M","D",".",0.77884,127,24,".",".","P01116-2;P01116",0.1902,"P01116",1,"T;T;T;T","0.802;0.741","CM076251","KRAS",null,0.66056,0,"CCDS8703.1","D","rs121913530",0.02,null,7.743,"g.chr12:25398285C>G",null,128,3,"Small GTP-binding protein domain (1);",null,"TCGA-2J-AABT-01A-11D-A40W-08",12,25289552,null,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.47941,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-HV-A5A5-01","TCGA-HV-A5A5-10",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","targeted",null,null,"Illumina GAIIx",91,7,12,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,1,98,2,2,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,91,0.78595,null,"12p12.1",null,null,0.99,0.99,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,2.024156,15813,".","SO:0001583",422,0.8502,0,0,1,0.80357,null,3845,41,5.68,".",1,".",1,null,25349,4.409094,null,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-5.317441,1.93,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",{"$nulls":3},0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.79,"B;P","p.G12D","-",12,null,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.52,0.13729,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.13,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,null,"Familial Cancer Database",0,1,0,0.981909,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.928016,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.01998835,"d":"2.00E-02"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9999987,"d":"1.00E+00"},2,0,"M","D",".",0.77884,11,7,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",null,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,12,3,"Small GTP-binding protein domain (1);",null,"TCGA-HV-A5A5-01A-11D-A26I-08",12,25289551,533,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[null,"KRAS",null,"broad.mit.edu","GRCh37",12,25398284,25398284,"+","missense_variant","Missense_Mutation","SNP","C","C","T","rs121913529",null,"TCGA-FB-AAPS-01","TCGA-FB-AAPS-11",null,null,"C","T","C","C",null,"Valid","Somatic","Phase_I","WXS","KRAS_deep",null,null,"Illumina GAIIx",259,13,49,0,"ENST00000256078.4:c.35G>A","p.Gly12Asp","p.G12D","ENST00000256078","NM_033360.2",12,"gGt/gAt",0,1,"D",0.71417,"Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)",2.668,0,98,2,1,23.4,"RASK_HUMAN",1,1,"c.35G>A","KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000311936.3_Missense_Mutation_p.G12D","-1.19;-1.19;-1.19;-1.19","G",".;RASK_HUMAN","protein_coding",".",".",0.90409,256,0.78595,5,"12p12.1",null,null,0.95,0.95,null,"ENSP00000256078:G12D","all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)","protein_coding",1,2,"OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)",0.88126,2,1.99731,15813,".","SO:0001583",582,0.8502,0,1,1,0.80357,null,3845,14,5.68,".",1,".",0,1,25349,4.409094,1,0,0.35714,"c.(34-36)gGt>gAt","D",0.85682,null,null,-4.741986,2,119,"TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)","12;12",12,null,null,0.998,"Substitution - Missense(15812)|Deletion - Frameshift(1)","Mis","C",0.563,1,"-",0.72,"B;P","p.G12D","-",12,524,"Noonan syndrome;Cardiofaciocutaneous syndrome","G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)",2,0.85919,121404,0.5809,"NM_033360.2",3.245,".",".",null,0,"0.0:1.0:0.0:0.0",0.95712,0.8787,".","ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131",0,"GGT",2,"D","ENSP00000308495:G12D;ENSP00000452512:G12D;ENSP00000256078:G12D;ENSP00000451856:G12D",5.68,"OTTHUMT00000412232.1","KNOWN",".",0.53,0.093656,1,null,".",0.8334,1,0.91818,1,"UBE2L3/KRAS(2)","D","KRAS-004",null,".","Dom","Kirsten rat sarcoma viral oncogene homolog",0.1,"ENST00000256078.4","not_organism_supported|basic|appris_candidate_longest|CCDS",44,8006,"Familial Cancer Database",0,1,0,0.999536,0,0.348,18.3719,"Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS","GCCTACGCCACCAGCTCCAAC",0,"p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)","ENSG00000133703","yes","L, E, M, O",2,0,0.888046,0.90789,"NP_203524.1",1,"missense",0.80722,"0.257;0.361",{"v":0.06188499,"d":"6.19E-02"},"B;B","pancreatic, colorectal, lung, thyroid, AML, others",{"v":0.9996447,"d":"1.00E+00"},8,0,"M","D",".",0.77884,48,13,".",".","P01116-2;P01116",0.267,"P01116",1,"T;T;T;T","0.385;0.517",null,"KRAS",7493,0.87932,1,"CCDS8703.1","D",null,0,null,7.743,"g.chr12:25398284C>T",null,49,1,"Small GTP-binding protein domain (1);",null,"TCGA-FB-AAPS-01A-12D-A397-08",12,25289551,266,"ENST00000256078.4","hg19","v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog",0.41619,10]
[]
[]
["Part2","Tumor_Sample","HSF1",{"$nulls":3},"Part3"]
["HSF1_EXPRESSION","TCGA-3A-A9IO-01A",4.04769543,{"$nulls":3},"Tumor_Sample_KRASMUT","HSF1","Merge","Tumor_Sample_KRASWT","HSF1"]
[null,"TCGA-US-A774-01A",4.122861114,{"$nulls":3},"TCGA-2J-AAB1-01A",4.3103296319255,null,"TCGA-2J-AABA-01A",4.03170843277077]
[null,"TCGA-HZ-A49H-01A",3.7977394,{"$nulls":3},"TCGA-2J-AAB4-01A",4.40752054079656,null,"TCGA-2J-AABP-01A",4.57944032027794]
[null,"TCGA-FB-A4P5-01A",4.0965199,{"$nulls":3},"TCGA-2J-AAB6-01A",4.38662696104298,null,"TCGA-2L-AAQM-01A",3.98746521240974]
[null,"TCGA-FB-AAPS-01A",4.120017275,{"$nulls":3},"TCGA-2J-AAB8-01A",3.71137827297135,null,"TCGA-3A-A9I5-01A",4.38985889939828]
[null,"TCGA-3A-A9IN-01A",4.197604707,{"$nulls":3},"TCGA-2J-AAB9-01A",4.58689034004585,null,"TCGA-3A-A9IJ-01A",4.53573444180516]
[null,"TCGA-HV-A5A5-01A",3.981025124,{"$nulls":3},"TCGA-2J-AABE-01A",4.26932440762464,null,"TCGA-3A-A9IL-01A",4.22229273207736]
[null,"TCGA-H6-8124-01A",3.963851875,{"$nulls":3},"TCGA-2J-AABF-01A",4.0579660934957,null,"TCGA-3A-A9IN-01A",4.19760470660745]
[null,"TCGA-US-A77G-01A",4.527094108,{"$nulls":3},"TCGA-2J-AABH-01A",5.57739578427507,null,"TCGA-3A-A9IO-01A",4.04769542854728]
[null,"TCGA-3A-A9IJ-01A",4.53573444,{"$nulls":3},"TCGA-2J-AABI-01A",4.99385692204011,null,"TCGA-3A-A9IR-01A",3.95150130946418]
[null,"TCGA-HZ-A8P0-01A",4.116795768,{"$nulls":3},"TCGA-2J-AABK-01A",3.94414636181662,null,"TCGA-3A-A9IS-01A",4.80756878805731]
[null,"TCGA-IB-7644-01A",4.015163554,{"$nulls":3},"TCGA-2J-AABO-01A",4.12888179346132,null,"TCGA-3A-A9IV-01A",3.52860810513467]
[null,"TCGA-IB-A7LX-01A",5.378070303,{"$nulls":3},"TCGA-2J-AABR-01A",3.91009334483381,null,"TCGA-3A-A9J0-01A",4.05116105377077]
[null,"TCGA-2J-AABK-01A",3.944146,{"$nulls":3},"TCGA-2J-AABT-01A",4.45990382413467,null,"TCGA-3E-AAAY-01A",4.07056761493123]
[null,"TCGA-HZ-A9TJ-06A",4.442667253,{"$nulls":3},"TCGA-2J-AABU-01A",4.31138465691117,null,"TCGA-F2-6880-01A",4.40307606911461]
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