{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["appendix A","appendix B","Sheet3"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"appendix A","index":0,"n_rows":184,"n_cols":3,"rows_kept":184,"merged":[[0,0,0,2]],"flags":["formulas_cached_only"]}
["Appendix A: Table. S1. A total of 182 potential targets"]
["Target","Common name","Uniprot ID"]
["Aldose reductase   ","AKR1B1","P15121"]
["Acyl coenzyme A:cholesterol acyltransferase","CES1","P23141"]
["Signal transducer and activator of transcription 3","STAT3","P40763"]
["Protein-tyrosine phosphatase 1C","PTPN6","P29350"]
["Vascular endothelial growth factor receptor 2","KDR","P35968"]
["Epidermal growth factor receptor erbB1","EGFR","P00533"]
["PI3-kinase p110-alpha subunit","PIK3CA","P42336"]
["c-Jun N-terminal kinase 1","MAPK8","P45983"]
["LXR-alpha","NR1H3","Q13133"]
["Estrogen receptor alpha","ESR1","P03372"]
["Testis-specific androgen-binding protein","SHBG","P04278"]
["Cytochrome P450 2C19","CYP2C19","P33261"]
["Protein-tyrosine phosphatase 1B","PTPN1","P18031"]
["Butyrylcholinesterase","BCHE","P06276"]
["Vitamin D receptor","VDR","P11473"]
["Glucose-6-phosphate 1-dehydrogenase","G6PD","P11413"]
["Peroxisome proliferator-activated receptor alpha","PPARA","Q07869"]
["Peroxisome proliferator-activated receptor delta","PPARD","Q03181"]
["Peroxisome proliferator-activated receptor gamma","PPARG","P37231"]
["UDP-glucuronosyltransferase 2B7","UGT2B7","P16662"]
["11-beta-hydroxysteroid dehydrogenase 2","HSD11B2","P80365"]
["NADPH oxidase 4","NOX4","Q9NPH5"]
["Tyrosine-protein kinase SYK","SYK","P43405"]
["Glycogen synthase kinase-3 beta","GSK3B","P49841"]
["Matrix metalloproteinase 9","MMP9","P14780"]
["Matrix metalloproteinase 2","MMP2","P08253"]
["Matrix metalloproteinase 12","MMP12","P39900"]
["ATP-binding cassette sub-family G member 2","ABCG2","Q9UNQ0"]
["P-glycoprotein 1","ABCB1","P08183"]
["Arachidonate 12-lipoxygenase","ALOX12","P18054"]
["Cyclooxygenase-2","PTGS2","P35354"]
["Insulin-like growth factor I receptor","IGF1R","P08069"]
["Myeloperoxidase","MPO","P05164"]
["Matrix metalloproteinase 3","MMP3","P08254"]
["Serine/threonine-protein kinase AKT","AKT1","P31749"]
["Beta-secretase 1","BACE1","P56817"]
["Tyrosine-protein kinase receptor UFO","AXL","P30530"]
["NUAK family SNF1-like kinase 1","NUAK1","O60285"]
["Aldehyde reductase   (by homology)","AKR1A1","P14550"]
["Plasminogen","PLG","P00747"]
["PI3-kinase p110-delta subunit","PIK3CD","O00329"]
["PI3-kinase p110-gamma subunit","PIK3CG","P48736"]
["Hematopoietic prostaglandin D synthase","HPGDS","O60760"]
["Serine-protein kinase ATM","ATM","Q13315"]
["Cytochrome P450 24A1","CYP24A1","Q07973"]
["Mineralocorticoid receptor","NR3C2","P08235"]
["Cannabinoid receptor 1","CNR1","P21554"]
["Hepatocyte nuclear factor 4-alpha","HNF4A","P41235"]
["C-C chemokine receptor type 1","CCR1","P32246"]
["Histone-lysine N-methyltransferase EZH2","EZH2","Q15910"]
["MAP kinase p38 alpha","MAPK14","Q16539"]
["Bromodomain-containing protein 2","BRD2","P25440"]
["Aldehyde dehydrogenase","ALDH2","P05091"]
["Fatty acid binding protein adipocyte","FABP4","P15090"]
["Fatty acid-binding protein, liver","FABP1","P07148"]
["Acyl-CoA desaturase","SCD","O00767"]
["MAP kinase ERK1","MAPK3","P27361"]
["Short transient receptor potential channel 6","TRPC6","Q9Y210"]
["Mitogen-activated protein kinase kinase kinase 5","MAP3K5","Q99683"]
["Disintegrin and metalloproteinase domain-containing protein 17","ADAM17","P78536"]
["Hexokinase type IV","GCK","P35557"]
["Intercellular adhesion molecule-1","ICAM1","P05362"]
["P-selectin","SELP","P16109"]
["Leukocyte adhesion molecule-1","SELL","P14151"]
["Matrix metalloproteinase 1","MMP1","P03956"]
["Matrix metalloproteinase 8","MMP8","P22894"]
["Endothelin-converting enzyme 1","ECE1","P42892"]
["Integrin beta-3","ITGB3","P05106"]
["Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform","PIK3CB","P42338"]
["Sorbitol dehydrogenase","SORD","Q00796"]
["MAP kinase ERK2","MAPK1","P28482"]
["Vascular endothelial growth factor receptor 1","FLT1","P17948"]
["Matrix metalloproteinase 7","MMP7","P09237"]
["Type-1 angiotensin II receptor   ","AGTR1","P30556"]
["Glucose transporter","SLC2A1","P11166"]
["Nerve growth factor receptor Trk-A","NTRK1","P04629"]
["Tyrosine-protein kinase JAK1","JAK1","P23458"]
["Tyrosine-protein kinase JAK2","JAK2","O60674"]
["Sodium/glucose cotransporter 2","SLC5A2","P31639"]
["Serine/threonine-protein kinase receptor R3","ACVRL1","P37023"]
["Epoxide hydratase","EPHX2","P34913"]
["Cytochrome P450 11B2","CYP11B2","P19099"]
["Endothelin receptor ET-A","EDNRA","P25101"]
["Glutathione S-transferase Mu 1","GSTM1","P09488"]
["Interleukin-1 beta","IL1B","P01584"]
["Insulin receptor","INSR","P06213"]
["Protein tyrosine kinase 2 beta","PTK2B","Q14289"]
["Cyclooxygenase-1","PTGS1","P23219"]
["Cytochrome P450 2C9","CYP2C9","P11712"]
["Cytochrome P450 3A4","CYP3A4","P08684"]
["Trypsin I","PRSS1","P07477"]
["C-C chemokine receptor type 5","CCR5","P51681"]
["Dopamine D2 receptor","DRD2","P14416"]
["Cholesteryl ester transfer protein","CETP","P11597"]
["Calcitonin gene-related peptide type 1 receptor","CALCRL","Q16602"]
["Serotonin 2a (5-HT2a) receptor","HTR2A","P28223"]
["Disintegrin and metalloproteinase domain-containing protein 10","ADAM10","O14672"]
["TGF-beta receptor type I","TGFBR1","P36897"]
["Nitric-oxide synthase, brain","NOS1","P29475"]
["Cathepsin (B and K)","CTSB","P07858"]
["Bradykinin B1 receptor","BDKRB1","P46663"]
["Potassium voltage-gated channel subfamily KQT member 1","KCNQ1","P51787"]
["Leukotriene A4 hydrolase","LTA4H","P09960"]
["Apoptosis regulator Bcl-2","BCL2","P10415"]
["Kininogen-1","KNG1","P01042"]
["Solute carrier family 22 member 2","SLC22A2","O15244"]
["Plasma retinol-binding protein","RBP4","P02753"]
["Histone deacetylase 4","HDAC4","P56524"]
["Dopamine D3 receptor","DRD3","P35462"]
["C-C chemokine receptor type 2","CCR2","P41597"]
["Solute carrier family 22 member 12","SLC22A12","Q96S37"]
["Glucagon-like peptide 1 receptor","GLP1R","P43220"]
["Dual specificity mitogen-activated protein kinase kinase 2","MAP2K2","P36507"]
["Death-associated protein kinase 2","DAPK2","Q9UIK4"]
["Bile acid receptor FXR","NR1H4","Q96RI1"]
["Interleukin-6","IL6","P05231"]
["Transcription factor AP-1","JUN","P05412"]
["Vascular endothelial growth factor A","VEGFA","P15692"]
["Interleukin-10","IL10","P22301"]
["Endothelin-1","EDN1","P05305"]
["Nitric oxide synthase, endothelial","NOS3","P29474"]
["Urotensin II receptor","UTS2R","Q9UKP6"]
["78 kDa glucose-regulated protein","HSPA5","P11021"]
["Galectin-3","LGALS3","P17931"]
["Macrophage migration inhibitory factor","MIF","P14174"]
["Serum paraoxonase/arylesterase 1","PON1","P27169"]
["Kallikrein 1","KLK1","P06870"]
["Rho-associated protein kinase 1","ROCK1","Q13464"]
["Sphingosine kinase 1","SPHK1","Q9NYA1"]
["Serine/threonine-protein kinase Sgk1","SGK1","O00141"]
["Low affinity sodium-glucose cotransporter","SLC5A4","Q9NY91"]
["Neutrophil cytosol factor 1","NCF1","P14598"]
["Antileukoproteinase","SLPI","P03973"]
["Signal transducer and activator of transcription 1-alpha/beta","STAT1","P42224"]
["Protein kinase C beta type","PRKCB","P05771"]
["Gap junction alpha-1 protein","GJA1","P17302"]
["C-X-C motif chemokine 11","CXCL11","O14625"]
["Interleukin-8","CXCL8","P10145"]
["Superoxide dismutase [Cu-Zn]","SOD1","P00441"]
["C-C motif chemokine 2","CCL2","P13500"]
["Hypoxia-inducible factor 1-alpha","HIF1A","Q16665"]
["Caveolin-1","CAV1","Q03135"]
["Interleukin-1 alpha","IL1A","P01583"]
["Nuclear factor erythroid 2-related factor 2","NFE2L2","Q16236"]
["C-X-C motif chemokine 10","CXCL10","P02778"]
["Plasminogen activator inhibitor 1","SERPINE1","P05121"]
["Osteopontin","SPP1","P10451"]
["Bone morphogenetic protein 2","BMP2","P12643"]
["Transforming growth factor beta-1 proprotein","TGFB1","P01137"]
["Cyclin-dependent kinase inhibitor 2A","CDKN2A","P42771"]
["Transcription factor E2F1","E2F1","Q01094"]
["Thrombomodulin","THBD","P07204"]
["Insulin-like growth factor II","IGF2","P01344"]
["Catalase","CAT","P04040"]
["Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN","PTEN","P60484"]
["Pro-epidermal growth factor","EGF","P01133"]
["ATP synthase subunit beta, mitochondria","ATP5F1B","P06576"]
["NAD-dependent protein deacetylase sirtuin-1","SIRT1","Q96EB6"]
["Angiotensin-converting enzyme  ","ACE","P12821"]
["Matrix metalloproteinase 10","MMP10","P09238"]
["Transketolase","TKT","P29401"]
["Dipeptidyl peptidase IV","DPP4","P27487"]
["Nuclear factor NF-kappa-B p65 subunit","RELA","Q04206"]
["Nitric oxide synthase, inducible  ","NOS2","P35228"]
["Protein kinase C alpha type","PRKCA","P17252"]
["Tumor necrosis factor","TNF","P01375"]
["Protein kinase C epsilon type","PRKCE","Q02156"]
["Renin","REN","P00797"]
["Axin1/beta-catenin","CTNNB1","P35222"]
["Fibronectin","FN1","P02751"]
["C-X-C chemokine receptor type 4","CXCR4","P61073"]
["Heparanase","HPSE","Q9Y251"]
["Glucagon","GCG","P01275"]
["Tumor necrosis factor receptor superfamily member 11B","TNFRSF11B","O00300"]
["Metalloproteinase inhibitor 1","TIMP1","P01033"]
["Metalloproteinase inhibitor 2","TIMP2","P16035"]
["Fibroblast growth factor 2","FGF2","P09038"]
["Lipoprotein lipase","LPL","P06858"]
["Coagulation factor V","F5","P12259"]
["Cyclic AMP-responsive element-binding protein 1","CREB1","P16220"]
["Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2","INPPL1","O15357"]
["Tumor necrosis factor ligand superfamily member 6","FASLG","P48023"]

{"sheet":"appendix B","index":1,"n_rows":77,"n_cols":2,"rows_kept":77,"merged":[[0,0,0,1]],"flags":["formulas_cached_only"]}
["Appendix B: Table. S2. The code information for active ingredients "]
["active ingredients","code name"]
["isoimperatorin","M1"]
["1,2,5,6-tetrahydrotanshinone","M2"]
["5,6-dihydroxy-7-isopropyl-1,1-dimethyl-2,3-dihydrophenanthren-4-one","M3"]
["(E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-benzofuran-4-yl]acrylic acid","M4"]
["2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-3-benzofurancarboxaldehyde","M5"]
["przewaquinone c","M6"]
["cryptotanshinone","M7"]
["dihydrotanshinlactone","M8"]
["Isotanshinone II","M9"]
["miltipolone","M10"]
["Miltirone","M11"]
["tanshinaldehyde","M12"]
["Danshenol B","M13"]
["Danshenol A","M14"]
["deoxyneocryptotanshinone","M15"]
["dihydrotanshinoneⅠ","M16"]
["miltionone Ⅰ","M17"]
["miltionone Ⅱ","M18"]
["neocryptotanshinone ii","M19"]
["neocryptotanshinone","M20"]
["luteolin","M21"]
["salvilenone Ⅰ","M22"]
["salviolone","M23"]
["epidanshenspiroketallactone","M24"]
["tanshinone iia","M25"]
["α-amyrin","M26"]
["dan-shexinkum d","M27"]
["sclareol","M28"]
["Dehydrotanshinone II A","M29"]
["Baicalin","M30"]
["2-isopropyl-8-methylphenanthrene-3,4-dione","M31"]
["formyltanshinone","M32"]
["3-beta-Hydroxymethyllenetanshiquinone","M33"]
["Methylenetanshinquinone","M34"]
["(2R)-3-(3,4-dihydroxyphenyl)-2-[(Z)-3-(3,4-dihydroxyphenyl)acryloyl]oxy-propionic acid","M35"]
["(6S)-6-(hydroxymethyl)-1,6-dimethyl-8,9-dihydro-7H-naphtho[8,7-g]benzofuran-10,11-dione","M36"]
["tanshinone Ⅵ","M37"]
["przewalskin b","M38"]
["6-o-syringyl-8-o-acetyl shanzhiside methyl ester","M39"]
["prolithospermic acid","M40"]
["(Z)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxy-phenyl]acrylic acid","M41"]
["salvianolic acid g","M42"]
["salvianolic acid j","M43"]
["danshenspiroketallactone","M44"]
["1-methyl-8,9-dihydro-7H-naphtho[5,6-g]benzofuran-6,10,11-trione","M45"]
["3,9-di-O-methylnissolin","M46"]
["(6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-benzofurano[3,2-c]chromen-3-ol","M47"]
["(3R)-3-(2-hydroxy-3,4-dimethoxyphenyl)chroman-7-ol","M48"]
["isorhamnetin","M49"]
["kaempferol","M50"]
["quercetin","M51"]
["Jaranol","M52"]
["Bifendate","M53"]
["formononetin","M54"]
["isoflavanone","M55"]
["Calycosin","M56"]
["hederagenin","M57"]
["Sennoside E_qt","M58"]
["Toralactone","M59"]
["palmidin A","M60"]
["Daucosterol_qt","M61"]
["EUPATIN","M62"]
["Procyanidin B-5,3'-O-gallate","M63"]
["rhein","M64"]
["beta-sitosterol","M65"]
["aloe-emodin","M66"]
["lipase","M67"]
["gardnerilin a","M68"]
["hirudin","M69"]
["o-desulfated heparin","M70"]
["ursolic acid","M71"]
["heparin","M72"]
["genioisidic acid","M73"]
["genipinic acid","M74"]
["nadroparin","M75"]

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}