{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["Supplemental Table S1","Supplemental Table S2","Supplemental Table S3","Supplemental Table S4"],"not_rendered":{"external_links":1,"defined_names":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Supplemental Table S1","index":0,"n_rows":36,"n_cols":5,"rows_kept":36,"merged":[[0,0,0,4],[1,0,1,4],[2,0,2,4],[35,0,35,4]],"flags":["formulas_cached_only"]}
["Supplemental material "]
["Bidirectional association between serum carcinoembryonic antigen and metabolic syndrome among Chinese male population: Two cohort Studies"]
["Supplemental Table S1. Characteristics comparison between participants with and without Hyper-CEA in cross-sectional study (2014-2015)"]
["Characteristics","Hyper-CEA (N=1937)","Norm-CEA (N=15412)","t/χ2","P value"]
["Age (year)","51.83±14.35","43.94±13.48",581.401,"<0.001"]
["SBP (mmHg)","134.26±19.66","130.66±16.83",75.453,"<0.001"]
["DBP (mmHg)","85.36±12.24","84.19±11.59",17.299,"<0.001"]
["BMI (kg/m2)","25.73±3.29","25.58±3.29",3.503,0.061]
["FPG (mmol/l)","6.04±2.18","5.48±1.25",286.74,"<0.001"]
["TG (mmol/l)","1.56±0.97","1.54±0.96",0.363,0.547]
["HDL-C (mmol/l)","1.27±0.26","1.26±0.24",2.21,0.137]
["ALT (U/L)","22.86±12.23","24.89±14.26",35.736,"<0.001"]
["AST (U/L)","20.7±7.15","20.71±6.95",0.001,0.973]
["GGT (U/L)","37.67±41.36","34.24±28.93",21.326,"<0.001"]
["BUN (mmol/l)","5.12±1.23","5.00±1.16",17.206,"<0.001"]
["CREA (mmol/l)","79.34±11.16","80.91±10.54",37.376,"<0.001"]
["BUA (umol/L)","355.49±78.29","366.66±74.65",38.052,"<0.001"]
["HB (g/l)","154.87±11.05","155.74±10.18",12.372,"<0.001"]
["WBC (109 / l)","7.02±1.72","6.69±1.56",76.053,"<0.001"]
["Age group",{"$nulls":3},"<0.001"]
["20-45","674 (34.80)","9194 (59.65)"]
["46-65","913 (47.13)","5086 (33.00)"]
[">65","350 (18.07)","1132 (7.34)"]
["Smoking",null,null,132.147,"<0.001"]
["No (%)","926 (48.18)","9456 (61.79)"]
["Yes (%)","996 (51.82)","5847 (38.21)"]
["Alcohol intake",null,null,0.007,0.936]
["No (%)","718 (37.40)","5733 (37.49)"]
["Yes (%)","1202 (62.60)","9559 (62.51)"]
["Overweight (%)","1121 (57.87)","8640 (56.06)",2.298,0.13]
["Hyperglycemia (%)","749 (38.67)","4210 (27.32)",108.622,"<0.001"]
["Hypertension (%) ","1268 (65.46)","8932 (57.95)",40.029,"<0.001"]
["Elevated triglycerides (%)","620 (32.01)","4808 (31.20)",0.527,0.468]
["Reduced HDL-C (%)","266 (13.73)","1905 (12.36)",2.959,0.085]
["MetS","755 (38.98)","4857 (31.51)",43.799,"<0.001"]
["*P values were calculated by t test for quantitative variables and χ2 test for categorical variables. CEA: carcinoembryonic antigen; Hyper-CEA: elevated serum CEA level above the reference range; Norm-CEA: within the normal reference ranges of CEA; MetS: metabolic syndrome; SBP: systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; FPG: fasting plasma glucose; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transpeptidase; BUN: blood urea nitrogen; CREA: serum creatinine; BUA: blood uric acid; HB: hemoglobin; WBC: white blood cell count."]

{"sheet":"Supplemental Table S2","index":1,"n_rows":15,"n_cols":4,"rows_kept":15,"merged":[[0,0,0,3],[4,1,4,3],[7,1,7,3],[10,1,10,3],[13,1,13,3],[14,0,14,3]],"flags":["formulas_cached_only"]}
["Supplemental Table S2. Crude and adjusted odds ratios (95%CI) of Hyper-CEA in MetS in a cross-sectional study (2014-2015)"]
["Model ","OR (95%CI)","χ2","P value"]
["Model 1 a"]
["Hyper-CEA","1.39 (1.26 ,1.53)",43.523,"< 0.001"]
["Norm-CEA","reference"]
["Model 2 b"]
["Hyper-CEA","1.19 (1.07 ,1.31)",11.26,0.001]
["Norm-CEA","reference"]
["Model 3 c"]
["Hyper-CEA","1.15 (1.04 ,1.27)",7.327,0.007]
["Norm-CEA","reference"]
["Model 4 d"]
["Hyper-CEA","1.13 (1.01 ,1.26)",4.337,0.037]
["Norm-CEA","reference"]
["CEA: carcinoembryonic antigen; Hyper-CEA: elevated serum CEA level above the reference range; Norm-CEA: within the normal reference ranges of CEA; MetS: metabolic syndrome.\na: Model 1, crude model without adjusting for any confounders;\nb: Model 2, adjusted for age;\nc: Model 3, adjusted for age and smoking;\nd: Model 4 in subcohort A, adjusted for age, smoking, alcohol intake, the components of MetS, hemoglobin, white blood cell count, blood uric acid, gamma-glutamyl transpeptidase, alanine aminotransferase, aspartate aminotransferase, serum creatinine, and blood urea nitrogen levels.\n"]

{"sheet":"Supplemental Table S3","index":2,"n_rows":24,"n_cols":7,"rows_kept":24,"merged":[[0,0,0,6],[1,0,2,0],[1,1,1,3],[1,5,1,6],[2,1,2,2],[3,1,3,2],[4,1,4,3],[4,5,4,6],[5,1,5,2],[6,1,6,2],[7,1,7,2],[8,1,8,2],[9,1,9,2],[10,1,10,2],[10,5,10,6],[11,1,11,2],[11,5,11,6],[12,1,12,2],[13,1,13,2],[14,1,14,2],[15,1,15,2],[16,1,16,2],[17,1,17,2],[18,1,18,2],[19,1,19,2],[20,1,20,2],[21,1,21,2],[22,1,22,2],[23,0,23,6]],"flags":["formulas_cached_only"]}
["Supplemental Table S3. Crude and adjusted hazards ratios (95%CI) for incident MetS in subcohort A"]
["Characteristics","Single Cox model",{"$nulls":3},"Multivariable Cox model"]
[null,"Hazard ratio (95% CI)",null,"P value",null,"Hazard ratio (95% CI)","P value"]
["Age (year)"]
["≤ 45 y","reference",{"$nulls":3},"reference"]
["> 45 y and ≤65 y","1.46 (1.30, 1.63)",null,"<0.001 ",null,"1.37 (1.20, 1.56)","<0.001"]
["> 65 y","1.19 (0.96, 1.47)",null,0.114,null,"1.43 (1.10, 1.85)",0.007]
["ALT (U/L)","1.02 (1.02, 1.02)",null,"<0.001 ",null,"1.01 (1.01, 1.02)","<0.001"]
["AST (U/L)","1.02 (1.01, 1.03)",null,"<0.001 ",null,"0.98 (0.97, 0.99)",0.002]
["GGT (U/L)","1.01 (1.01, 1.01)",null,"<0.001 ",null,"1.01 (1.00, 1.01)","<0.001"]
["BUN (mmol/l)","1.03 (0.99, 1.08)",null,0.162,null,"--"]
["CREA (mmol/l)","1.00 (1.00, 1.01)",null,0.286,null,"--"]
["BUA (umol/L)","1.00 (1.00, 1.00)",null,"<0.001 ",null,"1.00 (1.00, 1.00)","<0.001"]
["HB (g/l)","1.01 (1.00, 1.02)",null,0.001,null,"1.00 (1.00, 1.01)",0.508]
["WBC (109 / l)","1.14 (1.10, 1.17)",null,"<0.001 ",null,"1.07 (1.03, 1.11)",0.001]
["Smoking","1.21 (1.09, 1.35)",null,"<0.001 ",null,"1.02 (0.90, 1.16)",0.739]
["Alcohol intake","1.23 (1.10, 1.38)",null,"<0.001 ",null,"1.10 (0.97, 1.25)",0.129]
["Overweight ","3.19 (2.86, 3.56)",null,"<0.001 ",null,"3.85 (3.38, 4.39)","<0.001"]
["Hyperglycemia","1.66 (1.45, 1.91)",null,"<0.001 ",null,"2.60 (2.20, 3.08)","<0.001"]
["Hypertension ","1.44 (1.29, 1.60)",null,"<0.001 ",null,"1.95 (1.71, 2.22)","<0.001"]
["Elevated triglycerides ","1.97 (1.75, 2.22)",null,"<0.001 ",null,"2.48 (2.14, 2.89)","<0.001"]
["Reduced HDL-C","2.58 (1.91, 3.48)",null,"<0.001 ",null,"4.83 (3.42, 6.81)","<0.001"]
["Hyper-CEA","0.94 (0.76, 1.18)",null,0.602,null,"0.89 (0.71, 1.12)",0.326]
["CEA: carcinoembryonic antigen; Hyper-CEA: elevated serum CEA level above the reference range; MetS: metabolic syndrome; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transpeptidase; BUN: blood urea nitrogen; CREA: serum creatinine; BUA: blood uric acid; HB: hemoglobin; WBC: white blood cell count; HDL-C: high-density lipoprotein cholesterol."]

{"sheet":"Supplemental Table S4","index":3,"n_rows":19,"n_cols":6,"rows_kept":19,"merged":[[0,0,0,5],[1,0,2,0],[1,1,1,2],[1,4,1,5],[4,1,4,2],[4,4,4,5],[8,4,8,5],[9,4,9,5],[10,4,10,5],[12,4,12,5],[13,4,13,5],[16,4,16,5],[18,0,18,5]],"flags":["formulas_cached_only"]}
["Supplemental Table S4. Crude and adjusted hazards ratios (95%CI)  for incident Hyper-CEA in subcohort B"]
["Characteristics","Single Cox model",null,null,"Multivariable Cox model"]
[null,"Hazard ratio (95% CI)","P value",null,"Hazard ratio (95% CI)","P value"]
["Age (year)"]
["≤ 45 y","reference",null,null,"reference"]
["> 45 y and ≤65 y","1.80 (1.51, 2.14)","<0.001 ",null,"1.75 (1.46, 2.09)","<0.001 "]
["> 65 y","2.72 (2.13, 3.47)","<0.001 ",null,"3.12 (2.39, 4.08)","<0.001 "]
["ALT (U/L)","0.99 (0.99, 1.00)",0.055,null,"1.00 (0.99, 1.00)",0.376]
["AST (U/L)","1.01 (0.99, 1.02)",0.311,null,"--"]
["GGT (U/L)","1.00 (1.00, 1.00)",0.111,null,"--"]
["BUN (mmol/l)","1.04 (0.97, 1.11)",0.251,null,"--"]
["CREA (mmol/l)","0.99 (0.98, 1.00)",0.015,null,"0.99 (0.98, 1.00)",0.013]
["BUA (umol/L)","1.00 (1.00, 1.00)",0.226,null,"--"]
["HB (g/l)","1.00 (0.99, 1.00)",0.318,null,"--"]
["WBC (109 / l)","1.10 (1.05, 1.16)","<0.001 ",null,"1.09 (1.03, 1.15)",0.002]
["Smoking","1.47 (1.25, 1.72)","<0.001 ",null,"1.55 (1.31, 1.84)","<0.001 "]
["Alcohol intake","1.00 (0.84, 1.18)",0.963,null,"--"]
["MetS","1.17 (0.99,  1.40)",0.07,null,"1.02 (0.84, 1.22)",0.864]
["CEA: carcinoembryonic antigen; Hyper-CEA: elevated serum CEA level above the reference range; MetS: metabolic syndrome; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transpeptidase; BUN: blood urea nitrogen; CREA: serum creatinine; BUA: blood uric acid; HB: hemoglobin; WBC: white blood cell count."]