{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Supplementary Table S4"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Supplementary Table S4","index":0,"n_rows":122,"n_cols":14,"rows_kept":122,"flags":["formulas_cached_only"]}
["Term_ID","Term_description","ListHit","ListTotal","PopHit","PopTotal","GeneRatio","BgRatio","Enrichment_score","GeneIds","GeneSymbols","P_value","FDR_bh","Classification_level1"]
["ko04510","Focal adhesion",11,62,192,5439,0.177419354838709,0.0353006067291781,5.02595766129032,"LAMB1;PIK3R1;ITGA4;PRKCB;PDGFRA;FLT4;LAMC3;HGF;FLT1;COL4A1;ITGA8","LAMB1;PIK3R1;ITGA4;PRKCB;PDGFRA;FLT4;LAMC3;HGF;FLT1;COL4A1;ITGA8",{"v":8.37488892090073e-06,"d":"8.37E-06"},0.00101336155942898,"Cellular Processes"]
["ko04514","Cell adhesion molecules (CAMs)",8,62,113,5439,0.129032258064516,0.020775877918735,6.21067656294604,"VCAN;CDH5;ITGA4;VCAM1;NTNG2;SDC1;ITGA8;ITGB2","VCAN;CDH5;ITGA4;VCAM1;NTNG2;SDC1;ITGA8;ITGB2",{"v":3.59658272129192e-05,"d":"3.60E-05"},0.00217593254638161,"Environmental Information Processing"]
["ko04512","ECM-receptor interaction",6,62,76,5439,0.0967741935483871,0.0139731568302996,6.92572156196944,"ITGA4;LAMC3;ITGA8;SDC1;COL4A1;LAMB1","ITGA4;LAMC3;ITGA8;SDC1;COL4A1;LAMB1",0.000201531690534412,0.00812844485155464,"Environmental Information Processing"]
["ko04670","Leukocyte transendothelial migration",6,62,109,5439,0.0967741935483871,0.0200404486118771,4.82894347440071,"PIK3R1;CDH5;ITGA4;PRKCB;VCAM1;ITGB2","PIK3R1;CDH5;ITGA4;PRKCB;VCAM1;ITGB2",0.00139440032852965,0.0343314898968885,"Organismal Systems"]
["ko04015","Rap1 signaling pathway",8,62,193,5439,0.129032258064516,0.0354844640558926,3.63630285809794,"PIK3R1;PRKCB;PDGFRA;FLT4;ADORA2A;HGF;FLT1;ITGB2","PIK3R1;PRKCB;PDGFRA;FLT4;ADORA2A;HGF;FLT1;ITGB2",0.00141865660730944,0.0343314898968885,"Environmental Information Processing"]
["ko04151","PI3K-Akt signaling pathway",10,62,299,5439,0.161290322580645,0.0549733406876264,2.93397345992016,"LAMB1;PIK3R1;ITGA4;PDGFRA;FLT4;LAMC3;HGF;FLT1;COL4A1;ITGA8","LAMB1;PIK3R1;ITGA4;PDGFRA;FLT4;LAMC3;HGF;FLT1;COL4A1;ITGA8",0.00181815082993667,0.0366660417370563,"Environmental Information Processing"]
["ko04960","Aldosterone-regulated sodium reabsorption",3,62,33,5439,0.0483870967741935,0.00606729178157749,7.97507331378299,"PRKCB;PIK3R1;SLC9A3R2","PRKCB;PIK3R1;SLC9A3R2",0.0060336333566626,0.0884908819463944,"Organismal Systems"]
["ko04973","Carbohydrate digestion and absorption",3,62,34,5439,0.0483870967741935,0.00625114910829196,7.74051233396584,"PRKCB;AMY2A;PIK3R1","PRKCB;AMY2A;PIK3R1",0.00656434445548005,0.0884908819463944,"Organismal Systems"]
["ko00950","Isoquinoline alkaloid biosynthesis",2,62,11,5439,0.032258064516129,0.00202243059385916,15.9501466275659,"MAOA;TH","MAOA;TH",0.00658196642576487,0.0884908819463944,"Metabolism"]
["ko04014","Ras signaling pathway",7,62,204,5439,0.112903225806451,0.0375068946497517,3.01019924098671,"PIK3R1;PRKCB;PDGFRA;FLT4;RASGRP1;HGF;FLT1","PIK3R1;PRKCB;PDGFRA;FLT4;RASGRP1;HGF;FLT1",0.00804783218894903,0.0973787694862833,"Environmental Information Processing"]
["ko04060","Cytokine-cytokine receptor interaction",6,62,183,5439,0.0967741935483871,0.0336458907887479,2.87625594923321,"TNFRSF11A;PDGFRA;FLT4;HGF;TNFRSF19;FLT1","TNFRSF11A;PDGFRA;FLT4;HGF;TNFRSF19;FLT1",0.0172383532026283,0.189621885228911,"Environmental Information Processing"]
["ko04614","Renin-angiotensin system",2,62,19,5439,0.032258064516129,0.00349328920757492,9.23429541595925,"ACE;CTSA","ACE;CTSA",0.0193015153014814,0.194623612623271,"Organismal Systems"]
["ko00340","Histidine metabolism",2,62,22,5439,0.032258064516129,0.00404486118771833,7.97507331378299,"MAOA;ASPA","MAOA;ASPA",0.0255109425337381,0.237448003583255,"Metabolism"]
["ko04917","Prolactin signaling pathway",3,62,69,5439,0.0483870967741935,0.0126861555432984,3.81416549789621,"TH;PIK3R1;TNFRSF11A","TH;PIK3R1;TNFRSF11A",0.0434351357972613,0.37540367367633,"Organismal Systems"]
["ko04010","MAPK signaling pathway",6,62,234,5439,0.0967741935483871,0.0430226144511858,2.24937965260545,"PRKCB;PDGFRA;RASGRP1;DUSP8;MAP3K5;MECOM","PRKCB;PDGFRA;RASGRP1;DUSP8;MAP3K5;MECOM",0.0491364132135879,0.382627731187404,"Environmental Information Processing"]
["ko00350","Tyrosine metabolism",2,62,32,5439,0.032258064516129,0.00588343445486302,5.4828629032258,"MAOA;TH","MAOA;TH",0.0509526991227988,0.382627731187404,"Metabolism"]
["ko04064","NF-kappa B signaling pathway",3,62,76,5439,0.0483870967741935,0.0139731568302996,3.46286078098472,"PRKCB;TNFRSF11A;VCAM1","PRKCB;TNFRSF11A;VCAM1",0.0551362415088631,0.382627731187404,"Environmental Information Processing"]
["ko04727","GABAergic synapse",3,62,77,5439,0.0483870967741935,0.0141570141570141,3.41788856304985,"GABARAPL1;PRKCB;PLCL1","GABARAPL1;PRKCB;PLCL1",0.0569198277799445,0.382627731187404,"Organismal Systems"]
["ko04810","Regulation of actin cytoskeleton",5,62,189,5439,0.0806451612903225,0.0347490347490347,2.32078853046594,"PIK3R1;ITGA4;PDGFRA;ITGA8;ITGB2","PIK3R1;ITGA4;PDGFRA;ITGA8;ITGB2",0.0631601873765747,0.400780192319478,"Cellular Processes"]
["ko04666","Fc gamma R-mediated phagocytosis",3,62,82,5439,0.0483870967741935,0.0150763007905865,3.20948072383949,"PRKCB;WASF3;PIK3R1","PRKCB;WASF3;PIK3R1",0.066244659887517,0.400780192319478,"Organismal Systems"]
["ko04650","Natural killer cell mediated cytotoxicity",3,62,86,5439,0.0483870967741935,0.0158117300974443,3.06020255063766,"PRKCB;PIK3R1;ITGB2","PRKCB;PIK3R1;ITGB2",0.0741792675483703,0.427413874921562,"Organismal Systems"]
["ko04668","TNF signaling pathway",3,62,89,5439,0.0483870967741935,0.0163633020775877,2.95704965567234,"MAP3K5;PIK3R1;VCAM1","MAP3K5;PIK3R1;VCAM1",0.0803970218930744,0.434122036866078,"Environmental Information Processing"]
["ko04066","HIF-1 signaling pathway",3,62,90,5439,0.0483870967741935,0.0165471594043022,2.92419354838709,"PRKCB;FLT1;PIK3R1","PRKCB;FLT1;PIK3R1",0.0825190648588414,0.434122036866078,"Environmental Information Processing"]
["ko04726","Serotonergic synapse",3,62,98,5439,0.0483870967741935,0.018018018018018,2.68548387096774,"MAOA;PRKCB;ALOX5","MAOA;PRKCB;ALOX5",0.100346915714239,0.500173786233117,"Organismal Systems"]
["ko04913","Ovarian steroidogenesis",2,62,48,5439,0.032258064516129,0.00882515168229454,3.65524193548387,"FSHR;ALOX5","FSHR;ALOX5",0.103341691370478,0.500173786233117,"Organismal Systems"]
["ko04919","Thyroid hormone signaling pathway",3,62,103,5439,0.0483870967741935,0.0189373046515903,2.55512057626057,"FOXO1;PRKCB;PIK3R1","FOXO1;PRKCB;PIK3R1",0.112215449586367,0.501580972372162,"Organismal Systems"]
["ko04725","Cholinergic synapse",3,62,104,5439,0.0483870967741935,0.0191211619783048,2.53055210918114,"PRKCB;KCNQ3;PIK3R1","PRKCB;KCNQ3;PIK3R1",0.114652134556807,0.501580972372162,"Organismal Systems"]
["ko04360","Axon guidance",4,62,164,5439,0.064516129032258,0.030152601581173,2.13965381589299,"TRPC5;SEMA3G;PIK3R1;NTNG2","TRPC5;SEMA3G;PIK3R1;NTNG2",0.116068324185293,0.501580972372162,"Organismal Systems"]
["ko04071","Sphingolipid signaling pathway",3,62,109,5439,0.0483870967741935,0.0200404486118771,2.41447173720035,"MAP3K5;PRKCB;PIK3R1","MAP3K5;PRKCB;PIK3R1",0.127134106459202,0.510149248665638,"Environmental Information Processing"]
["ko04020","Calcium signaling pathway",4,62,174,5439,0.064516129032258,0.0319911748483177,2.0166852057842,"PRKCB;PDGFRA;STIM2;ADORA2A","PRKCB;PDGFRA;STIM2;ADORA2A",0.13582744100962,0.510149248665638,"Environmental Information Processing"]
["ko04213","Longevity regulating pathway - multiple species",2,62,57,5439,0.032258064516129,0.0104798676227247,3.07809847198641,"FOXO1;PIK3R1","FOXO1;PIK3R1",0.137197719109426,0.510149248665638,"Organismal Systems"]
["ko04640","Hematopoietic cell lineage",2,62,58,5439,0.032258064516129,0.0106637249494392,3.0250278086763,"ITGA4;CD7","ITGA4;CD7",0.1411005111066,0.510149248665638,"Organismal Systems"]
["ko04728","Dopaminergic synapse",3,62,115,5439,0.0483870967741935,0.021143592572164,2.28849929873772,"MAOA;PRKCB;TH","MAOA;PRKCB;TH",0.142729461639659,0.510149248665638,"Organismal Systems"]
["ko00360","Phenylalanine metabolism",1,62,14,5439,0.0161290322580645,0.00257400257400257,6.26612903225806,"MAOA","MAOA",0.148450763079775,0.510149248665638,"Metabolism"]
["ko00603","Glycosphingolipid biosynthesis - globo series",1,62,14,5439,0.0161290322580645,0.00257400257400257,6.26612903225806,"B3GALT5","B3GALT5",0.148450763079775,0.510149248665638,"Metabolism"]
["ko04370","VEGF signaling pathway",2,62,61,5439,0.032258064516129,0.0112152969295826,2.87625594923321,"PRKCB;PIK3R1","PRKCB;PIK3R1",0.152949909597515,0.510149248665638,"Environmental Information Processing"]
["ko04971","Gastric acid secretion",2,62,62,5439,0.032258064516129,0.0113991542562971,2.82986472424557,"KCNK2;PRKCB","KCNK2;PRKCB",0.156943338802698,0.510149248665638,"Organismal Systems"]
["ko04024","cAMP signaling pathway",4,62,188,5439,0.064516129032258,0.0345651774223202,1.86650652024708,"CNGB1;FSHR;PIK3R1;ADORA2A","CNGB1;FSHR;PIK3R1;ADORA2A",0.165625831048405,0.510149248665638,"Environmental Information Processing"]
["ko04610","Complement and coagulation cascades",2,62,65,5439,0.032258064516129,0.0119507262364405,2.69925558312655,"F10;ITGB2","F10;ITGB2",0.169040867000042,0.510149248665638,"Organismal Systems"]
["ko04391","Hippo signaling pathway - fly",2,62,65,5439,0.032258064516129,0.0119507262364405,2.69925558312655,"TSHZ3;DCHS1","TSHZ3;DCHS1",0.169040867000042,0.510149248665638,"Environmental Information Processing"]
["ko04068","FoxO signaling pathway",3,62,126,5439,0.0483870967741935,0.0231660231660231,2.08870967741935,"FOXO1;GABARAPL1;PIK3R1","FOXO1;GABARAPL1;PIK3R1",0.172860489217282,0.510149248665638,"Environmental Information Processing"]
["ko04662","B cell receptor signaling pathway",2,62,68,5439,0.032258064516129,0.0125022982165839,2.58017077798861,"PRKCB;PIK3R1","PRKCB;PIK3R1",0.18129475849014,0.522301566126357,"Organismal Systems"]
["ko04974","Protein digestion and absorption",2,62,71,5439,0.032258064516129,0.0130538701967273,2.47114947751022,"COL4A1;COL15A1","COL4A1;COL15A1",0.193681149007498,0.545009744881566,"Organismal Systems"]
["ko00601","Glycosphingolipid biosynthesis - lacto and neolacto series",1,62,21,5439,0.0161290322580645,0.00386100386100386,4.1774193548387,"B3GALT5","B3GALT5",0.214318197418483,0.589375042900829,"Metabolism"]
["ko04744","Phototransduction",1,62,22,5439,0.0161290322580645,0.00404486118771833,3.98753665689149,"CNGB1","CNGB1",0.223309019081288,0.594027442027055,"Organismal Systems"]
["ko01040","Biosynthesis of unsaturated fatty acids",1,62,23,5439,0.0161290322580645,0.0042287185144328,3.81416549789621,"FADS2","FADS2",0.232198596487566,0.594027442027055,"Metabolism"]
["ko04012","ErbB signaling pathway",2,62,81,5439,0.032258064516129,0.014892443463872,2.16606929510155,"PRKCB;PIK3R1","PRKCB;PIK3R1",0.235647249729741,0.594027442027055,"Environmental Information Processing"]
["ko04013","MAPK signaling pathway - fly",2,62,81,5439,0.032258064516129,0.014892443463872,2.16606929510155,"MAP3K5;TBX2","MAP3K5;TBX2",0.235647249729741,0.594027442027055,"Environmental Information Processing"]
["ko04392","Hippo signaling pathway -multiple species",1,62,25,5439,0.0161290322580645,0.00459643316786173,3.50903225806451,"DCHS1","DCHS1",0.24967849277386,0.604221952512742,"Environmental Information Processing"]
["ko00592","alpha-Linolenic acid metabolism",1,62,25,5439,0.0161290322580645,0.00459643316786173,3.50903225806451,"FADS2","FADS2",0.24967849277386,0.604221952512742,"Metabolism"]
["ko04211","Longevity regulating pathway",2,62,86,5439,0.032258064516129,0.0158117300974443,2.04013503375844,"FOXO1;PIK3R1","FOXO1;PIK3R1",0.25685893430805,0.607580791983422,"Organismal Systems"]
["ko04540","Gap junction",2,62,87,5439,0.032258064516129,0.0159955874241588,2.0166852057842,"PRKCB;PDGFRA","PRKCB;PDGFRA",0.26110910068709,0.607580791983422,"Cellular Processes"]
["ko04139","Regulation of mitophagy - yeast",1,62,27,5439,0.0161290322580645,0.00496414782129067,3.24910394265233,"GABARAPL1","GABARAPL1",0.266766713314801,0.609033439831905,"Cellular Processes"]
["ko04070","Phosphatidylinositol signaling system",2,62,92,5439,0.032258064516129,0.0169148740577312,1.9070827489481,"PRKCB;PIK3R1","PRKCB;PIK3R1",0.282366991137765,0.626000644518256,"Environmental Information Processing"]
["ko04723","Retrograde endocannabinoid signaling",2,62,95,5439,0.032258064516129,0.0174664460378746,1.84685908319185,"PRKCB;NAPEPLD","PRKCB;NAPEPLD",0.295107930762825,0.626000644518256,"Organismal Systems"]
["ko04140","Regulation of autophagy",1,62,31,5439,0.0161290322580645,0.00569957712814855,2.82986472424557,"GABARAPL1","GABARAPL1",0.299802482521708,0.626000644518256,"Cellular Processes"]
["ko04660","T cell receptor signaling pathway",2,62,97,5439,0.032258064516129,0.0178341606913035,1.80877951446624,"PIK3R1;RASGRP1","PIK3R1;RASGRP1",0.303587681189174,0.626000644518256,"Organismal Systems"]
["ko00982","Drug metabolism - cytochrome P450",1,62,32,5439,0.0161290322580645,0.00588343445486302,2.7414314516129,"MAOA","MAOA",0.307829894887482,0.626000644518256,"Metabolism"]
["ko00250","Alanine, aspartate and glutamate metabolism",1,62,32,5439,0.0161290322580645,0.00588343445486302,2.7414314516129,"ASPA","ASPA",0.307829894887482,0.626000644518256,"Metabolism"]
["ko04750","Inflammatory mediator regulation of TRP channels",2,62,99,5439,0.032258064516129,0.0182018753447324,1.77223851417399,"PRKCB;PIK3R1","PRKCB;PIK3R1",0.312051641232896,0.626000644518256,"Organismal Systems"]
["ko00830","Retinol metabolism",1,62,33,5439,0.0161290322580645,0.00606729178157749,2.65835777126099,"DHRS3","DHRS3",0.315766744623663,0.626000644518256,"Metabolism"]
["ko04724","Glutamatergic synapse",2,62,103,5439,0.032258064516129,0.0189373046515903,1.70341371750704,"SLC1A6;PRKCB","SLC1A6;PRKCB",0.328917966286926,0.626000644518256,"Organismal Systems"]
["ko04672","Intestinal immune network for IgA production",1,62,35,5439,0.0161290322580645,0.00643500643500643,2.50645161290322,"ITGA4","ITGA4",0.331372765761305,0.626000644518256,"Organismal Systems"]
["ko04380","Osteoclast differentiation",2,62,104,5439,0.032258064516129,0.0191211619783048,1.68703473945409,"TNFRSF11A;PIK3R1","TNFRSF11A;PIK3R1",0.333119257106992,0.626000644518256,"Organismal Systems"]
["ko04961","Endocrine and other factor-regulated calcium reabsorption",1,62,36,5439,0.0161290322580645,0.0066188637617209,2.43682795698924,"PRKCB","PRKCB",0.33904391463952,0.626000644518256,"Organismal Systems"]
["ko00380","Tryptophan metabolism",1,62,37,5439,0.0161290322580645,0.00680272108843537,2.37096774193548,"MAOA","MAOA",0.346628456055563,0.626000644518256,"Metabolism"]
["ko00260","Glycine, serine and threonine metabolism",1,62,37,5439,0.0161290322580645,0.00680272108843537,2.37096774193548,"MAOA","MAOA",0.346628456055563,0.626000644518256,"Metabolism"]
["ko00500","Starch and sucrose metabolism",1,62,38,5439,0.0161290322580645,0.00698657841514984,2.30857385398981,"AMY2A","AMY2A",0.354127351970101,0.630138376299739,"Metabolism"]
["ko02010","ABC transporters",1,62,39,5439,0.0161290322580645,0.00717043574186431,2.24937965260545,"ABCB1LA","ABCB1LA",0.361541553820375,0.631543777306748,"Environmental Information Processing"]
["ko04722","Neurotrophin signaling pathway",2,62,113,5439,0.032258064516129,0.020775877918735,1.55266914073651,"MAP3K5;PIK3R1","MAP3K5;PIK3R1",0.37057527428743,0.631543777306748,"Organismal Systems"]
["ko04152","AMPK signaling pathway",2,62,113,5439,0.032258064516129,0.020775877918735,1.55266914073651,"FOXO1;PIK3R1","FOXO1;PIK3R1",0.37057527428743,0.631543777306748,"Environmental Information Processing"]
["ko04270","Vascular smooth muscle contraction",2,62,117,5439,0.032258064516129,0.0215113072255929,1.4995864350703,"PRKCB;ADORA2A","PRKCB;ADORA2A",0.386975432132921,0.639416496236794,"Organismal Systems"]
["ko01212","Fatty acid metabolism",1,62,43,5439,0.0161290322580645,0.00790586504872219,2.04013503375844,"FADS2","FADS2",0.390370087858805,0.639416496236794,"Metabolism"]
["ko04611","Platelet activation",2,62,118,5439,0.032258064516129,0.0216951645523074,1.48687807545106,"PIK3R1;RASGRP1","PIK3R1;RASGRP1",0.391048105136551,0.639416496236794,"Organismal Systems"]
["ko00330","Arginine and proline metabolism",1,62,44,5439,0.0161290322580645,0.00808972237543666,1.99376832844574,"MAOA","MAOA",0.397374731028595,0.641097899392801,"Metabolism"]
["ko00310","Lysine degradation",1,62,46,5439,0.0161290322580645,0.0084574370288656,1.9070827489481,"PHYKPL","PHYKPL",0.411147298775709,0.644144125959121,"Metabolism"]
["ko04910","Insulin signaling pathway",2,62,123,5439,0.032258064516129,0.0226144511858797,1.42643587726199,"FOXO1;PIK3R1","FOXO1;PIK3R1",0.411233632982202,0.644144125959121,"Organismal Systems"]
["ko04210","Apoptosis",2,62,124,5439,0.032258064516129,0.0227983085125942,1.41493236212278,"MAP3K5;PIK3R1","MAP3K5;PIK3R1",0.415233403510838,0.644144125959121,"Cellular Processes"]
["ko00590","Arachidonic acid metabolism",1,62,48,5439,0.0161290322580645,0.00882515168229454,1.82762096774193,"ALOX5","ALOX5",0.424610066822459,0.65035212766478,"Metabolism"]
["ko04310","Wnt signaling pathway",2,62,130,5439,0.032258064516129,0.023901452472881,1.34962779156327,"PRKCB;PRICKLE2","PRKCB;PRICKLE2",0.438951364247383,0.656081474341161,"Environmental Information Processing"]
["ko04214","Apoptosis - fly",1,62,51,5439,0.0161290322580645,0.00937672366243794,1.7201138519924,"MAP3K5","MAP3K5",0.444238303054587,0.656081474341161,"Cellular Processes"]
["ko04145","Phagosome",2,62,134,5439,0.032258064516129,0.0246368817797389,1.30934039480019,"PLA2R1;ITGB2","PLA2R1;ITGB2",0.45448109209498,0.656081474341161,"Cellular Processes"]
["ko04923","Regulation of lipolysis in adipocytes",1,62,53,5439,0.0161290322580645,0.00974443831586688,1.65520389531345,"PIK3R1","PIK3R1",0.4569562451576,0.656081474341161,"Organismal Systems"]
["ko04918","Thyroid hormone synthesis",1,62,54,5439,0.0161290322580645,0.00992829564258135,1.62455197132616,"PRKCB","PRKCB",0.463207398672379,0.656081474341161,"Organismal Systems"]
["ko04062","Chemokine signaling pathway",2,62,137,5439,0.032258064516129,0.0251884537598823,1.28066870732281,"PRKCB;PIK3R1","PRKCB;PIK3R1",0.465971905393409,0.656081474341161,"Organismal Systems"]
["ko04976","Bile secretion",1,62,57,5439,0.0161290322580645,0.0104798676227247,1.5390492359932,"ABCB1LA","ABCB1LA",0.48153913759596,0.656081474341161,"Organismal Systems"]
["ko04720","Long-term potentiation",1,62,58,5439,0.0161290322580645,0.0106637249494392,1.51251390433815,"PRKCB","PRKCB",0.487511745080893,0.656081474341161,"Organismal Systems"]
["ko04150","mTOR signaling pathway",2,62,143,5439,0.032258064516129,0.0262915977201691,1.22693435596661,"PRKCB;PIK3R1","PRKCB;PIK3R1",0.488532948864214,0.656081474341161,"Environmental Information Processing"]
["ko04072","Phospholipase D signaling pathway",2,62,143,5439,0.032258064516129,0.0262915977201691,1.22693435596661,"PDGFRA;PIK3R1","PDGFRA;PIK3R1",0.488532948864214,0.656081474341161,"Environmental Information Processing"]
["ko04924","Renin secretion",1,62,59,5439,0.0161290322580645,0.0108475822761537,1.48687807545106,"ACE","ACE",0.493416645992113,0.656081474341161,"Organismal Systems"]
["ko03320","PPAR signaling pathway",1,62,59,5439,0.0161290322580645,0.0108475822761537,1.48687807545106,"FADS2","FADS2",0.493416645992113,0.656081474341161,"Organismal Systems"]
["ko04721","Synaptic vesicle cycle",1,62,61,5439,0.0161290322580645,0.0112152969295826,1.4381279746166,"CPLX1","CPLX1",0.505026340189403,0.664219425683888,"Organismal Systems"]
["ko04022","cGMP-PKG signaling pathway",2,62,150,5439,0.032258064516129,0.0275785990071704,1.16967741935483,"CNGB1;PIK3R1","CNGB1;PIK3R1",0.514113912096206,0.664644740879504,"Environmental Information Processing"]
["ko04921","Oxytocin signaling pathway",2,62,151,5439,0.032258064516129,0.0277624563338849,1.16193121127964,"PRKCB;PIK3R1","PRKCB;PIK3R1",0.517701213352783,0.664644740879504,"Organismal Systems"]
["ko04730","Long-term depression",1,62,64,5439,0.0161290322580645,0.011766868909726,1.37071572580645,"PRKCB","PRKCB",0.521951692191187,0.664644740879504,"Organismal Systems"]
["ko04111","Cell cycle - yeast",1,62,65,5439,0.0161290322580645,0.0119507262364405,1.34962779156327,"NIPBLL","NIPBLL",0.527465923835368,0.664644740879504,"Cellular Processes"]
["ko04664","Fc epsilon RI signaling pathway",1,62,66,5439,0.0161290322580645,0.0121345835631549,1.32917888563049,"PIK3R1","PIK3R1",0.532917563719566,0.664644740879504,"Organismal Systems"]
["ko04212","Longevity regulating pathway - worm",1,62,67,5439,0.0161290322580645,0.0123184408898694,1.30934039480019,"GABARAPL1","GABARAPL1",0.53830731079497,0.664644740879504,"Organismal Systems"]
["ko04970","Salivary secretion",1,62,70,5439,0.0161290322580645,0.0128700128700128,1.25322580645161,"PRKCB","PRKCB",0.554112070150684,0.670005852280059,"Organismal Systems"]
["ko04925","Aldosterone synthesis and secretion",1,62,70,5439,0.0161290322580645,0.0128700128700128,1.25322580645161,"PRKCB","PRKCB",0.554112070150684,0.670005852280059,"Organismal Systems"]
["ko04911","Insulin secretion",1,62,71,5439,0.0161290322580645,0.0130538701967273,1.23557473875511,"PRKCB","PRKCB",0.559261083308148,0.670005852280059,"Organismal Systems"]
["ko04520","Adherens junction",1,62,74,5439,0.0161290322580645,0.0136054421768707,1.18548387096774,"WASF3","WASF3",0.574359663010454,0.681348227688872,"Cellular Processes"]
["ko04914","Progesterone-mediated oocyte maturation",1,62,77,5439,0.0161290322580645,0.0141570141570141,1.13929618768328,"PIK3R1","PIK3R1",0.588949064770232,0.691872202302893,"Organismal Systems"]
["ko04972","Pancreatic secretion",1,62,80,5439,0.0161290322580645,0.0147085861371575,1.09657258064516,"PRKCB","PRKCB",0.603046187748527,0.69493894016735,"Organismal Systems"]
["ko04922","Glucagon signaling pathway",1,62,80,5439,0.0161290322580645,0.0147085861371575,1.09657258064516,"FOXO1","FOXO1",0.603046187748527,0.69493894016735,"Organismal Systems"]
["ko04620","Toll-like receptor signaling pathway",1,62,84,5439,0.0161290322580645,0.0154440154440154,1.04435483870967,"PIK3R1","PIK3R1",0.621104762115521,0.705641136704563,"Organismal Systems"]
["ko04915","Estrogen signaling pathway",1,62,85,5439,0.0161290322580645,0.0156278727707299,1.03206831119544,"PIK3R1","PIK3R1",0.625491597732817,0.705641136704563,"Organismal Systems"]
["ko04912","GnRH signaling pathway",1,62,86,5439,0.0161290322580645,0.0158117300974443,1.02006751687922,"PRKCB","PRKCB",0.629828452595808,0.705641136704563,"Organismal Systems"]
["ko04080","Neuroactive ligand-receptor interaction",3,62,287,5439,0.0483870967741935,0.0527670527670527,0.91699449252557,"FSHR;TAC1;ADORA2A","FSHR;TAC1;ADORA2A",0.643287506377098,0.714108149280999,"Environmental Information Processing"]
["ko04916","Melanogenesis",1,62,91,5439,0.0161290322580645,0.0167310167310167,0.964019851116625,"PRKCB","PRKCB",0.65078240842914,0.715860649272054,"Organismal Systems"]
["ko04713","Circadian entrainment",1,62,93,5439,0.0161290322580645,0.0170987313844456,0.943288241415192,"PRKCB","PRKCB",0.658833263962962,0.718187612067733,"Organismal Systems"]
["ko00240","Pyrimidine metabolism",1,62,102,5439,0.0161290322580645,0.0187534473248758,0.860056925996204,"CMPK2","CMPK2",0.69285954773422,0.748535761391435,"Metabolism"]
["ko04142","Lysosome",1,62,108,5439,0.0161290322580645,0.0198565912851627,0.812275985663082,"CTSA","CTSA",0.713665136520123,0.764190101937476,"Cellular Processes"]
["ko04530","Tight junction",1,62,124,5439,0.0161290322580645,0.0227983085125942,0.707466181061394,"PRKCB","PRKCB",0.762605184828995,0.808046990462898,"Cellular Processes"]
["ko04261","Adrenergic signaling in cardiomyocytes",1,62,126,5439,0.0161290322580645,0.0231660231660231,0.696236559139785,"PIK3R1","PIK3R1",0.768111864423003,0.808046990462898,"Organismal Systems"]
["ko04144","Endocytosis",2,62,246,5439,0.032258064516129,0.0452289023717595,0.713217938630999,"PDGFRA;FLT1","PDGFRA;FLT1",0.778410754187329,0.808046990462898,"Cellular Processes"]
["ko04630","Jak-STAT signaling pathway",1,62,131,5439,0.0161290322580645,0.0240853097995955,0.6696626446688,"PIK3R1","PIK3R1",0.781334693257513,0.808046990462898,"Environmental Information Processing"]
["ko04550","Signaling pathways regulating pluripotency of stem cells",1,62,137,5439,0.0161290322580645,0.0251884537598823,0.640334353661408,"PIK3R1","PIK3R1",0.796225610206638,0.816468634194943,"Cellular Processes"]
["ko04141","Protein processing in endoplasmic reticulum",1,62,147,5439,0.0161290322580645,0.027027027027027,0.596774193548387,"MAP3K5","MAP3K5",0.818856993535347,0.823076995804718,"Genetic Information Processing"]
["ko04740","Olfactory transduction",1,62,148,5439,0.0161290322580645,0.0272108843537414,0.592741935483871,"CNGB1","CNGB1",0.820979228310135,0.823076995804718,"Organismal Systems"]
["ko04390","Hippo signaling pathway",1,62,149,5439,0.0161290322580645,0.0273947416804559,0.588763801688677,"ITGB2","ITGB2",0.823076995804718,0.823076995804718,"Environmental Information Processing"]