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{"sheet":"drug_specific","index":0,"n_rows":112,"n_cols":10,"rows_kept":112,"merged":[[0,0,1,2],[0,3,2,9]]}
["GDSC Drug",null,null,"Median predicted ln(IC50) value for the tumor type in parentheses compared to the median of medians of the predicted ln(IC50) values for all tumor types in parentheses"]
[]
["ID","Name","Target"]
[1804,"Acetalax","UNK","2.910(blca)(4.11)","2.868(brca)(4.11)","2.816(cesc)(4.11)","2.968(esca)(4.11)","2.726(hnsc)(4.11)","2.036(prad)(4.11)","3.102(ucec)(4.11)"]
[1372,"Trametinib","MEK1, MEK2","-1.274(coad)(0.02)","-1.173(read)(0.02)","-1.880(skcm)(0.02)","-1.096(uvm)(0.02)"]
[1051,"Alisertib","AURKA","0.576(dlbc)(2.45)","1.151(lgg)(2.45)","1.417(pcpg)(2.45)","1.359(thym)(2.45)"]
[1910,"ABT737","BCL2, BCL-XL,  BCL-W, BCL-B, BFL1","0.471(dlbc)(2.08)","1.003(lgg)(2.08)","1.025(pcpg)(2.08)","0.864(thym)(2.08)"]
[1549,"Sapitinib","EGFR, ERBB2, ERBB3","2.612(cesc)(3.83)","2.634(esca)(3.83)","2.049(hnsc)(3.83)","2.572(lusc)(3.83)"]
[1909,"Venetoclax","BCL2","0.561(dlbc)(2.30)","1.258(lgg)(2.30)","1.074(thym)(2.30)"]
[1248,"Daporinad","NAMPT","-4.732(dlbc)(-2.52)","-3.847(tgct)(-2.52)","-3.939(thym)(-2.52)"]
[1011,"Navitoclax","BCL2, BCL-XL, BCL-W","0.036(dlbc)(1.76)","0.707(lgg)(1.76)","0.057(thym)(1.76)"]
[1131,"PRIMA-1MET","TP53 activation","3.280(dlbc)(4.91)","3.779(thym)(4.91)","3.847(uvm)(4.91)"]
[1819,"Docetaxel","Microtubule stabiliser","-3.325(dlbc)(-1.26)","-2.300(hnsc)(-1.26)","-2.487(thym)(-1.26)"]
[211,"TL-2-105","not defined","3.034(dlbc)(4.21)","3.060(thym)(4.21)"]
[1594,"OSI-027","MTORC1, MTORC2","2.803(brca)(4.47)","3.394(prad)(4.47)"]
[1809,"Teniposide","topoisomerase II","-1.189(dlbc)(0.83)","-0.371(thym)(0.83)"]
[1818,"Vincristine","Microtubules","-3.450(dlbc)(-1.03)","-2.518(thym)(-1.03)"]
[1373,"Dabrafenib","BRAF","2.901(dlbc)(4.83)","2.162(skcm)(4.83)"]
[222,"BX-912","PDK1 (PDPK1)","1.818(dlbc)(3.10)","2.094(thym)(3.10)"]
[1810,"Mitoxantrone"," ","-1.260(dlbc)(0.80)","-0.556(thym)(0.80)"]
[1008,"Methotrexate","Antimetabolite","-1.566(dlbc)(0.16)","-1.038(thym)(0.16)"]
[261,"TL-1-85","TAK","2.048(dlbc)(3.61)","2.373(thym)(3.61)"]
[1559,"Luminespib","HSP90","-2.924(dlbc)(-1.64)","-2.649(hnsc)(-1.64)"]
[29,"AZ628","BRAF","-0.034(skcm)(1.84)","0.717(uvm)(1.84)"]
[1242,"(5Z)-7-Oxozeaenol","TAK1 ","-0.109(skcm)(1.16)","0.146(uvm)(1.16)"]
[1080,"Paclitaxel","Microtubule stabiliser","-3.398(dlbc)(-1.80)","-3.009(thym)(-1.80)"]
[346,"THZ-2-102-1","CDK7","-2.307(dlbc)(-0.58)","-1.629(thym)(-0.58)"]
[299,"OSI-027","MTORC1, MTORC2","-0.031(dlbc)(1.43)","0.079(thym)(1.43)"]
[1036,"PLX-4720","BRAF","3.632(dlbc)(4.64)","2.578(skcm)(4.64)"]
[1047,"Nutlin-3a (-)","MDM2","3.332(dlbc)(4.84)"]
[1003,"Camptothecin","TOP1","-3.324(dlbc)(-2.13)"]
[1088,"Irinotecan","TOP1","1.466(dlbc)(2.89)"]
[1190,"Gemcitabine","Pyrimidine antimetabolite","-1.878(dlbc)(0.11)"]
[1814,"Nelarabine","DNA synethesis","4.398(thym)(6.12)"]
[1931,"MIRA-1","TP53","4.714(dlbc)(5.74)"]
[1089,"Oxaliplatin","DNA alkylating agent","2.766(dlbc)(4.22)"]
[1375,"Temozolomide","DNA alkylating agent","5.198(dlbc)(6.38)"]
[1808,"Topotecan","DNA topoisomerases","-1.131(dlbc)(0.20)"]
[1806,"Oxaliplatin","DNA alkylating agent","3.867(dlbc)(5.33)"]
[1001,"AICA Ribonucleotide","AMPK agonist","7.009(dlbc)(8.37)"]
[1060,"PD0325901","MEK1, MEK2","-1.089(skcm)(0.56)"]
[1928,"I-BRD9","BRD9","3.550(dlbc)(4.83)"]
[1079,"Dasatinib","ABL, SRC, Ephrins, PDGFR, KIT","0.063(kirp)(1.27)"]
[427,"Ara-G","Anti-metabolite","4.134(thym)(5.40)"]
[301,"PHA-793887","CDK2, CDK7, CDK5","1.832(dlbc)(3.10)"]
[2048,"Vinorelbine","Microtubule destabiliser","-4.677(dlbc)(-2.46)"]
[1005,"Cisplatin","DNA crosslinker","2.380(dlbc)(3.56)"]
[1564,"SCH772984","ERK1, ERK2","1.310(skcm)(2.85)"]
[1177,"Niraparib","PARP1, PARP2","3.005(dlbc)(4.58)"]
[1013,"Nilotinib","ABL","2.455(dlbc)(3.70)"]
[1179,"MK-1775","WEE1, PLK1","-0.195(dlbc)(1.12)"]
[1249,"BMS-345541","IKK-1, IKK-2","2.686(dlbc)(3.81)"]
[412,"Venotoclax","BCL-2 selective","-0.009(dlbc)(1.15)"]
[275,"I-BET-762","BRD2, BRD3, BRD4","3.172(dlbc)(4.31)"]
[1835,"Elephantin"," ","2.669(dlbc)(3.76)"]
[2111,"VE821","ATR","2.687(dlbc)(4.56)"]
[333,"T0901317","LXR, FXR","3.708(dlbc)(4.74)"]
[332,"XMD15-27","CAMK2","3.822(dlbc)(4.84)"]
[1529,"Pevonedistat","NAE","0.068(dlbc)(1.60)"]
[1004,"Vinblastine","Microtubule destabiliser","-4.333(dlbc)(-2.93)"]
[290,"KIN001-260","IKKB","3.970(dlbc)(5.11)"]
[306,"Fedratinib","JAK2","1.359(dlbc)(2.61)"]
[1073,"5-Fluorouracil","Antimetabolite (DNA & RNA)","3.358(dlbc)(5.00)"]
[2045,"AMG-319","PI3K (beta sparing)","3.651(dlbc)(5.08)"]
[1250,"AZ960","JAK2, JAK3","1.113(dlbc)(2.65)"]
[356,"AT7867","AKT","2.674(dlbc)(3.71)"]
[1511,"Epirubicin","Anthracycline","-1.717(dlbc)(-0.33)"]
[1849,"Sabutoclax","BCL2,  BCL-XL,  BFL1, MCL1","-0.886(dlbc)(0.23)"]
[302,"PI-103","PI3Kalpha, DAPK3, CLK4, PIM3, HIPK2","0.307(dlbc)(1.35)"]
[1811,"Dactinomycin","inhibits RNA synthesis","-3.091(dlbc)(-2.05)"]
[1046,"Wee1 Inhibitor","WEE1, CHEK1","1.555(dlbc)(2.76)"]
[1911,"Dactinomycin","RNA polymerase","-5.373(dlbc)(-3.94)"]
[1593,"Entinostat","HDAC1, HDAC3","1.749(dlbc)(2.96)"]
[1239,"YK-4-279","RNA helicase A","1.613(dlbc)(2.75)"]
[2046,"MK-8776","CHEK1, CHEK2, CDK2","1.862(dlbc)(3.36)"]
[1006,"Cytarabine","Antimetabolite","0.497(dlbc)(1.91)"]
[1624,"I-BET-762","BRD2, BRD3, BRD4","2.281(dlbc)(3.84)"]
[331,"QL-X-138","BTK","0.568(dlbc)(1.80)"]
[1816,"Fulvestrant","Hormone receptor","3.924(dlbc)(4.95)"]
[1621,"PCI-34051","HDAC8, HDAC6, HDAC1","3.714(dlbc)(4.85)"]
[155,"Ponatinib","ABL, PDGFRA, VEGFR2, FGFR1, SRC, TIE2, FLT3","-0.398(dlbc)(0.82)"]
[344,"THZ-2-49","CDK9","1.651(dlbc)(3.20)"]
[1017,"Olaparib","PARP1, PARP2","3.290(dlbc)(4.51)"]
[295,"NVP-BHG712","EPHB4","2.502(dlbc)(3.56)"]
[1009,"Tretinoin","Retinoic acid ","2.747(dlbc)(4.10)"]
[1371,"PLX-4720","BRAF","2.332(skcm)(4.34)"]
[1377,"Afatinib","ERBB2, EGFR","2.397(hnsc)(3.42)"]
[1996,"MIM1","MCL1","3.132(dlbc)(4.21)"]
[328,"SNX-2112","HSP90","-0.938(dlbc)(0.12)"]
[303,"PIK-93","PI3Kgamma","1.507(dlbc)(3.01)"]
[1625,"RVX-208","BRD4","3.769(dlbc)(5.03)"]
[1061,"SB590885","BRAF","2.306(skcm)(3.83)"]
[1855,"KRAS (G12C) Inhibitor-12","KRAS (G12C)","3.725(dlbc)(4.78)"]
[1054,"Palbociclib","CDK4, CDK6","3.143(dlbc)(4.16)"]
[1259,"Talazoparib","PARP1, PARP2","1.906(dlbc)(3.34)"]
[292,"Masitinib","KIT, PDGFRA, PDGFRB","2.516(dlbc)(3.75)"]
[1917,"AZD6738","ATR","1.350(dlbc)(2.53)"]
[256,"JW-7-24-1","LCK","0.688(dlbc)(2.01)"]
[428,"Pemetrexed","folate antimetabolite","2.291(dlbc)(3.34)"]
[1617,"AZD5582","XIAP, cIAP","1.020(dlbc)(2.32)"]
[1022,"AZD7762","CHEK1, CHEK2","-0.855(dlbc)(0.58)"]
[1626,"OTX015","BRD2, BRD3, BRD4","1.446(dlbc)(3.08)"]
[1613,"VE-822","ATR","2.587(dlbc)(3.88)"]
[2106,"Uprosertib","AKT1, AKT2, AKT3","1.850(dlbc)(2.86)"]
[461,"NSC319726","P53 Mut specific","-3.841(dlbc)(-2.80)"]
[1933,"P22077","USP7, USP47","3.888(dlbc)(4.93)"]
[273,"CUDC-101","HDAC1-10, EGFR, ERBB2","-0.807(dlbc)(0.24)"]
[2170,"AT13148","AKT1","3.032(dlbc)(4.06)"]
[1218,"JQ1","BRD2, BRD3, BRD4, BRDT","1.005(dlbc)(2.26)"]
[1631,"PRT062607","SYK","2.356(dlbc)(3.74)"]
[1192,"GSK269962A","ROCK1, ROCK2","1.675(dlbc)(2.85)"]
[1614,"WZ4003","NUAK1, NUAK2","3.281(skcm)(4.32)"]