{"text_format":"3","workbook":"xlsx","n_sheets":1,"sheets":["pan_tumor_normal_medians"],"read":"whole","date_system":"1900"}

{"sheet":"pan_tumor_normal_medians","index":0,"n_rows":273,"n_cols":7,"rows_kept":273}
["Drug ID","Drug Name","Drug Target","Drug Pathway","Pan Tumor Median ln(IC50)","Pan Normal Median ln(IC50)","Diff."]
[11,"Paclitaxel","Microtubule stabiliser","microtubles",-3.176,-2.534,0.642]
[252,"WZ3105","SRC,ROCK2,NTRK2,FLT3,IRAK1,others","kinases",0.615,1.151,0.536]
[1248,"Daporinad","NAMPT","Metabolism",-2.417,-1.908,0.509]
[2048,"Vinorelbine","Microtubule destabiliser","microtubles",-2.386,-1.959,0.427]
[219,"AT-7519","CDKs","Cell cycle",1.398,1.762,0.364]
[1166,"QL-VIII-58","mTOR","mTOR",-0.955,-0.6,0.355]
[1804,"Acetalax","syntheticmineralocorticoid","Unclassified",3.789,4.136,0.347]
[268,"Sepantronium_bromide","BIRC5","NA",-3.163,-2.826,0.338]
[346,"THZ-2-102-1","CDK7","Cell cycle",-0.435,-0.099,0.336]
[1617,"AZD5582","XIAP,cIAP","Apoptosis",2.411,2.744,0.332]
[1080,"Paclitaxel","Microtubule stabiliser","microtubles",-1.796,-1.485,0.311]
[1372,"Trametinib","MEK1,MEK2","ERK/MAPK signaling",0.099,0.403,0.304]
[301,"PHA-793887","CDKs","Cell cycle",3.199,3.503,0.304]
[1051,"Alisertib","AURKA","Mitosis",2.539,2.827,0.288]
[1917,"AZD6738","ATR","Genome integrity",2.568,2.855,0.287]
[1818,"Vincristine","Microtubules","microtubles",-0.925,-0.639,0.286]
[1819,"Docetaxel","Microtubule stabiliser","microtubles",-1.231,-0.957,0.273]
[1026,"Tanespimycin","HSP90","protein stability",-0.081,0.19,0.271]
[2044,"Pyridostatin","G-quadruplexstabiliser","DNA synthesis",3.77,4.01,0.24]
[1529,"Pevonedistat","NAE","Other",1.681,1.914,0.233]
[407,"kb_NB_142-70","PKD","Other,kinases",2.774,3.007,0.233]
[1908,"Ulixertinib","ERK1,ERK2","ERK/MAPK signaling",3.194,3.419,0.225]
[299,"OSI-027","MTORC1,MTORC2","NA",1.551,1.775,0.224]
[1564,"SCH772984","ERK1,ERK2","ERK/MAPK signaling",2.876,3.095,0.219]
[2046,"MK-8776","CHEK1,CHEK2,CDK2","Cell cycle",3.49,3.699,0.209]
[1190,"Gemcitabine","Pyrimidineantimetabolite","DNA replication",0.092,0.294,0.202]
[1004,"Vinblastine","Microtubule destabiliser","microtubles",-2.808,-2.609,0.2]
[1249,"BMS-345541","IKK-1,IKK-2","Other",3.872,4.068,0.196]
[2106,"Uprosertib","AKT1,AKT2,AKT3","PI3K/MTOR signaling",2.899,3.092,0.194]
[1046,"Wee1_Inhibitor","WEE1,CHEK1","Cellcycle",2.757,2.948,0.191]
[1048,"Mirin","MRE11","Genome integrity",5.227,5.418,0.191]
[1932,"NVP-ADW742","IGF1R","IGF1R signaling",3.433,3.623,0.19]
[328,"SNX-2112","HSP90","NA",0.192,0.378,0.186]
[1060,"PD0325901","MEK1,MEK2","ERK/MAPK signaling",0.612,0.797,0.185]
[1613,"VE-822","ATR","Genome integrity",3.885,4.065,0.18]
[1161,"ZG-10","JNK1","NA",1.892,2.069,0.177]
[1941,"Sepantronium_bromide","BIRC5","Apoptosis",-3.737,-3.562,0.175]
[1266,"ICL1100013","N-myristoyltransferase1/2","NA",2.708,2.883,0.175]
[1526,"Refametinib","MEK1,MEK2","NA",1.654,1.821,0.167]
[1558,"Lapatinib","ERBB2,EGFR","EGFR signaling",3.557,3.724,0.167]
[2111,"VE821","ATR","Genome integrity",4.51,4.677,0.167]
[1593,"Entinostat","HDAC1,HDAC3","Chromatin histoneacetylation",2.942,3.105,0.164]
[1073,"5-Fluorouracil","Antimetabolite(DNA&RNA)","Other",5.004,5.168,0.164]
[134,"Etoposide","TOP2","NA",1.884,2.047,0.163]
[1855,"KRAS_(G12C)_Inhibitor-12","KRAS(G12C)","ERK/MAPK signaling",4.773,4.932,0.159]
[273,"CUDC-101","HDAC1-10,EGFR,ERBB2","NA",0.297,0.453,0.156]
[208,"Ispinesib_Mesylate","KSP","mitosis/cell cycle",-1.501,-1.346,0.155]
[1853,"OF-1","BRPF1B,BRPF2","Chromatin histoneacetylation",4.424,4.579,0.155]
[428,"Pemetrexed","folateantimetabolite","Metabolism",3.36,3.514,0.154]
[1912,"Afuresertib","AKT1,AKT2,AKT3","PI3K/MTOR signaling",2.638,2.79,0.152]
[1239,"YK-4-279","RNAhelicaseA","Other",2.747,2.897,0.15]
[2096,"VX-11e","ERK2","ERK/MAPK signaling",3.224,3.372,0.148]
[1786,"AZD4547","FGFR1,FGFR2,FGFR3","RTK signaling",3.131,3.278,0.147]
[1629,"ML323","USP1,UAF1","Protein stability",4.796,4.943,0.147]
[356,"AT7867","AKT","PI3K/MTOR signaling",3.655,3.8,0.145]
[1498,"Selumetinib","MEK1,MEK2","MEK signaling",1.606,1.749,0.143]
[1930,"Telomerase_Inhibitor_IX","Telomerase","Genome integrity",1.171,1.312,0.141]
[221,"TAK-715","p38alpha,p38beta","NA",4.744,4.884,0.14]
[474,"ARRY-520","KIF11","Cell cycle",-2.489,-2.35,0.139]
[29,"AZ628","BRAF","NA",1.843,1.982,0.139]
[1559,"Luminespib","HSP90","protein stability",-1.64,-1.504,0.136]
[1019,"Bosutinib","SRC,ABL,TEC","NA",2.451,2.587,0.136]
[449,"CD532","AURKA","Mitosis",0.368,0.503,0.135]
[1236,"UNC0638","G9aandGLPmethyltransferases","NA",3.568,3.704,0.135]
[1933,"P22077","USP7,USP47","Protein stability",4.941,5.076,0.135]
[1626,"OTX015","BRD2,BRD3,BRD4","Chromatinother",3.111,3.245,0.134]
[1016,"Temsirolimus","MTOR","mTOR",-1.639,-1.51,0.13]
[1849,"Sabutoclax","BCL2,BCL-XL,BFL1,MCL1","Apoptosis regulation",0.247,0.373,0.126]
[1022,"AZD7762","CHEK1,CHEK2","Cellcycle",0.578,0.701,0.123]
[1088,"Irinotecan","TOP1","DNA replication",2.913,3.035,0.122]
[1939,"UMI-77","MCL1","Apoptosis regulation",3.223,3.342,0.119]
[1816,"Fulvestrant","Hormonereceptor","Hormone-related",4.94,5.059,0.119]
[331,"QL-X-138","BTK","NA",1.806,1.924,0.118]
[1624,"I-BET-762","BRD2,BRD3,BRD4","Chromatinother",3.829,3.947,0.118]
[435,"C-75","FAS","Apoptosis regulation",4.719,4.837,0.118]
[330,"XMD13-2","RIPK1","NA",3.885,4,0.115]
[1371,"PLX-4720","BRAF","NA",4.331,4.445,0.114]
[1005,"Cisplatin","DNAcrosslinker","DNA replication",3.56,3.673,0.113]
[1008,"Methotrexate","Antimetabolite","NA",0.169,0.279,0.11]
[235,"QL-XII-47","BTK,BMX","NA",1.721,1.829,0.109]
[182,"Obatoclax_Mesylate","BCL2,BCL-XL,BCL-W,MCL1","NA",-0.218,-0.112,0.106]
[1037,"BX795","TBK1,PDK1(PDPK1),IKK,AURKB,AURKC","NA",2.487,2.592,0.105]
[1576,"IWP-2","PORCN","WNTsignaling",2.931,3.036,0.105]
[1085,"Sorafenib","PDGFR,KIT,VEGFR,RAF","Other,kinases",3.03,3.135,0.105]
[1012,"Vorinostat","HDACinhibitorClassI,IIa,IIb,IV","Chromatin histoneacetylation",1.931,2.034,0.103]
[1025,"SB216763","GSK3A,GSK3B","WNTsignaling",4.821,4.924,0.103]
[1250,"AZ960","JAK2,JAK3","Other,kinases",2.679,2.781,0.102]
[1061,"SB590885","BRAF","NA",3.823,3.924,0.102]
[2107,"LJI308","RSK2,RSK1,RSK3","PI3K/MTOR signaling",5.495,5.597,0.102]
[1179,"MK-1775","WEE1,PLK1","Cellcycle",1.166,1.267,0.101]
[1003,"Camptothecin","TOP1","DNA synthesis",-2.095,-1.997,0.099]
[1810,"Mitoxantrone",null,"DNA replication",0.832,0.931,0.099]
[1928,"I-BRD9","BRD9","Chromatinother",4.842,4.941,0.099]
[427,"Ara-G","Anti-metabolite","Other",5.382,5.481,0.099]
[308,"Foretinib","MET,KDR,TIE2,VEGFR3/FLT4,RON,PDGFR,FGFR1,EGFR","NA",0.575,0.673,0.098]
[1598,"LGK974","PORCN","WNTsignaling",4.454,4.552,0.098]
[1199,"Tamoxifen","ESR1","Hormone-related",4.033,4.13,0.097]
[576,"RU-SKI_43","Shh","Other",4.677,4.774,0.097]
[1809,"Teniposide","topoisomeraseII","DNA replication",0.891,0.985,0.094]
[59,"WZ-1-84","BMX","NA",3.69,3.784,0.094]
[1373,"Dabrafenib","BRAF","ERK/MAPK signaling",4.866,4.96,0.094]
[1635,"Picolinici-acid","Inflammatoryrelated","Other",5.354,5.448,0.094]
[1911,"Dactinomycin","RNA polymerase","RNA synthesis",-3.895,-3.802,0.093]
[222,"BX-912","PDK1(PDPK1)","NA",3.242,3.335,0.093]
[1916,"AZD5363","AKT1,AKT2,AKT3,ROCK2","Other,kinases",3.081,3.173,0.092]
[302,"PI-103","PI3Kalpha,DAPK3,CLK4,PIM3,HIPK2","NA",1.382,1.473,0.091]
[1634,"AGI-6780","IDH2R140Qmutant","Metabolism",4.591,4.681,0.09]
[1622,"Wnt-C59","PORCN","WNTsignaling",4.634,4.724,0.09]
[1054,"Palbociclib","CDK4,CDK6","Cellcycle",4.201,4.289,0.088]
[342,"Tenovin-6","SIRT","Chromatin histoneacetylation",2.415,2.502,0.087]
[294,"MPS-1-IN-1","MPS1","NA",4.352,4.438,0.086]
[1259,"Talazoparib","PARP1,PARP2","Genome integrity",3.32,3.405,0.085]
[317,"WYE-125132","mTOR","PI3K/MTOR signaling",0.045,0.127,0.083]
[1852,"LY2109761","TGFB1","Other",5.297,5.38,0.083]
[1825,"Podophyllotoxin_bromide","microtuble","microtubles",-0.241,-0.159,0.082]
[1510,"Linsitinib","IGF1R","IGF1R signaling",4.233,4.315,0.082]
[1802,"Zoledronate",null,"Unclassified",3.876,3.954,0.078]
[91,"GSK319347A","IKK","NA",4.123,4.201,0.078]
[1807,"Carmustine","nonspecificalkylatingagent","DNA replication",6.298,6.376,0.078]
[2043,"BIBR-1532","TERT","Genome integrity",5.172,5.249,0.077]
[1998,"BPD-00008900",null,"Other",4.819,4.894,0.075]
[1375,"Temozolomide","DNAalkylatingagent","DNA replication",6.383,6.457,0.075]
[1015,"CI-1040","MEK1,MEK2","NA",2.303,2.377,0.074]
[1192,"GSK269962A","ROCK1,ROCK2","Cytoskeleton",2.884,2.958,0.074]
[1200,"Fulvestrant","ESR","Hormone-related",3.105,3.179,0.074]
[1033,"Vismodegib","SMO","NA",4.696,4.769,0.073]
[1913,"AGI-5198","IDH1(R132H)","Metabolism",4.881,4.954,0.073]
[1925,"GDC0810","ESR1,ESR2","Hormone-related",5.164,5.237,0.073]
[1243,"Piperlongumine","Inducesreactiveoxygenspecies","NA",1.889,1.961,0.072]
[1083,"Crizotinib","MET,ALK,ROS1","RTK signaling",3.64,3.712,0.072]
[1021,"Axitinib","PDGFR,KIT,VEGFR","RTK signaling",2.539,2.61,0.071]
[1996,"MIM1","MCL1","Apoptosis regulation",4.229,4.3,0.071]
[1047,"Nutlin-3a_(-)","MDM2","p53 pathway",4.962,5.033,0.071]
[1180,"Dinaciclib","CDK1,CDK2,CDK5,CDK9","Cell cycle",-2.318,-2.248,0.07]
[257,"NPK76-II-72-1","PLK3","NA",3.618,3.688,0.07]
[1873,"Buparlisib","PI3Kalpha,PI3Kdelta,PI3Kbeta,PI3Kgamma","PI3K/MTOR signaling",1.175,1.243,0.069]
[2170,"AT13148","AKT1","PI3K/MTOR signaling",4.036,4.105,0.069]
[159,"HG6-64-1","BRAF","NA",1.389,1.456,0.067]
[1799,"Ibrutinib","BTK","Other,kinases",4.731,4.798,0.067]
[2040,"Foretinib","MET,KDR,TIE2,VEGFR3/FLT4,RON,PDGFR,FGFR1,EGFR","RTK signaling",1.144,1.211,0.066]
[345,"KIN001-270","CDK9","NA",5.28,5.346,0.066]
[432,"Flavopiridol","CDK","Cell cycle",-0.904,-0.839,0.065]
[1830,"Gallibiscoquinazole",null,"Unclassified",2.675,2.74,0.065]
[309,"Y-39983","ROCK","NA",4.827,4.892,0.065]
[173,"FH535","PPARgamma,PPARdelta","NA",1.892,1.956,0.064]
[438,"Panobinostat","HDAC","chromotine",-2.617,-2.555,0.062]
[1808,"Topotecan","DNA topoisomerases","DNA replication",0.202,0.264,0.062]
[1631,"PRT062607","SYK","Other,kinases",3.768,3.83,0.062]
[1009,"Tretinoin","Retinoicacid","NA",4.106,4.168,0.062]
[1936,"Savolitinib","MET","RTK signaling",2.721,2.782,0.061]
[226,"GSK1070916","AURKA,AURKC","NA",2.165,2.225,0.06]
[1242,"(5Z)-7-Oxozeaenol","TAK1","NA",1.22,1.28,0.059]
[1084,"Rapamycin","MTORC1","mTOR",-1.847,-1.789,0.058]
[371,"Torin_2","mTOR","mTOR",-0.952,-0.894,0.058]
[203,"BMS-345541","IKK1,IKK2","NA",3.307,3.365,0.058]
[326,"GSK690693","AKT1,AKT2,AKT3","NA",3.815,3.873,0.058]
[1089,"Oxaliplatin","DNAalkylatingagent","DNA replication",4.238,4.295,0.057]
[225,"Genentech_Cpd_10","AURKA,AURKB","NA",2.608,2.664,0.056]
[1620,"PFI3","Polybromo1,SMARCA4,SMARCA2","Chromatinother",5.5,5.556,0.056]
[1511,"Epirubicin","Anthracycline","DNA synthesis",-0.327,-0.272,0.055]
[1006,"Cytarabine","Antimetabolite","Other",1.947,2.002,0.055]
[1013,"Nilotinib","ABL","ABL signaling",3.656,3.711,0.055]
[1630,"Entospletinib","SYK","Other,kinases",4.039,4.094,0.055]
[376,"Brivanib,_BMS-540215","VEGFR,PDGFR","RTK signaling",4.66,4.714,0.054]
[1563,"EPZ5676","DOT1L","Chromatin histonemethylation",5.78,5.834,0.054]
[1001,"AICA_Ribonucleotide","AMPKagonist","NA",8.344,8.398,0.054]
[158,"PF-562271","FAK,FAK2","NA",2.018,2.071,0.053]
[1007,"Docetaxel","Microtubule stabiliser","microtubles",-4.167,-4.115,0.052]
[262,"VX-11e","ERK2","NA",3.198,3.249,0.051]
[1549,"Sapitinib","EGFR,ERBB2,ERBB3","EGFRsignaling",3.755,3.806,0.05]
[34,"Imatinib","ABL,KIT,PDGFR","NA",3.129,3.178,0.049]
[245,"UNC0638","G9aandGLPmethyltransferases","NA",3.668,3.717,0.049]
[2045,"AMG-319","PI3K(betasparing)","PI3K/MTOR signaling",5.083,5.132,0.049]
[1627,"GSK343","EZH2","Chromatin histonemethylation",3.081,3.129,0.048]
[1093,"GSK1904529A","IGF1R,IR","IGF1R signaling",4.701,4.748,0.047]
[461,"NSC319726","P53 Mut specific","p53 pathway",-2.827,-2.78,0.046]
[1811,"Dactinomycin","inhibits RNA synthesis","Transcription",-2.007,-1.961,0.046]
[1378,"Bleomycin_(50_uM)","dsDNAbreakinduction","NA",2.761,2.806,0.046]
[89,"Parthenolide","HDAC1","NA",3.413,3.459,0.046]
[1618,"GSK2606414","PERK","Metabolism",4.051,4.097,0.046]
[1036,"PLX-4720","BRAF","ERK/MAPK signaling",4.573,4.619,0.046]
[230,"GSK429286A","ROCK1,ROCK2","NA",5.212,5.258,0.046]
[1614,"WZ4003","NUAK1,NUAK2","Other,kinases",4.32,4.365,0.045]
[266,"Zibotentan","Endothelin-1receptor(EDNRA)","NA",5.651,5.696,0.045]
[333,"T0901317","LXR,FXR","NA",4.696,4.74,0.044]
[1237,"EPZ004777","DOT1L","Chromatin histonemethylation",5.317,5.361,0.044]
[1806,"Oxaliplatin","DNAalkylatingagent","DNA replication",5.349,5.392,0.043]
[5,"Sunitinib","PDGFR,KIT,VEGFR,FLT3,RET,CSF1R","NA",2.963,3.004,0.042]
[305,"TPCA-1","IKK2","NA",3.539,3.58,0.041]
[1017,"Olaparib","PARP1,PARP2","Genome integrity",4.529,4.569,0.041]
[1177,"Niraparib","PARP1,PARP2","Genome integrity",4.567,4.608,0.041]
[1615,"CZC24832","PI3Kgamma","PI3K/MTOR signaling",5.143,5.184,0.041]
[264,"ACY-1215","HDAC6","Chromatin histoneacetylation",1.926,1.966,0.04]
[298,"OSI-930","KIT","NA",4.316,4.356,0.04]
[1927,"GSK2578215A","LRRK2","Other,kinases",5.256,5.295,0.039]
[1578,"Leflunomide","Pyrimidinesynthesisinhibitor","DNA replication",5.37,5.409,0.039]
[409,"eEF2K_Inhibitor,_A-484954","eEF2K","Other,kinases",5.81,5.849,0.039]
[431,"Alisertib","AURKA","Mitosis",1.968,2.007,0.038]
[1263,"UNC0642","G9a(EHMT2),GLP(EHMT1)","Chromatin histonemethylation",1.782,1.819,0.037]
[344,"THZ-2-49","CDK9","NA",3.225,3.262,0.037]
[265,"Tubastatin_A","HDAC1,HDAC6,HDAC8","NA",4.967,5.004,0.037]
[447,"ETP-45835","MNK1,MNK2","Other,kinases",5.493,5.528,0.035]
[261,"TL-1-85","TAK","NA",3.746,3.779,0.033]
[282,"Pelitinib","EGFR","NA",1.891,1.923,0.032]
[329,"QL-XI-92","DDR1","NA",4.216,4.248,0.032]
[1049,"PD173074","FGFR1,FGFR3","RTK signaling",4.289,4.321,0.032]
[1814,"Nelarabine","DNAsynethesis","DNA replication",6.12,6.152,0.032]
[562,"AGI-6780","IDH2(R140Q)","Metabolism",1.575,1.605,0.03]
[1262,"UNC1215","L3MBTL3","NA",2.548,2.578,0.03]
[1218,"JQ1","BRD2,BRD3,BRD4,BRDT","NA",2.247,2.275,0.028]
[271,"VNLG/124","HDAC,RAR","NA",4.017,4.045,0.028]
[446,"MIM1","MCL-1","Apoptosis regulation",3.612,3.639,0.027]
[1621,"PCI-34051","HDAC8,HDAC6,HDAC1","Chromatin histoneacetylation",4.874,4.901,0.027]
[1014,"Refametinib","MEK1,MEK2","NA",1.403,1.429,0.026]
[1625,"RVX-208","BRD4","Chromatinother",5.037,5.062,0.025]
[408,"Sphingosine_Kinase_1_Inhibitor_II","SphingosineKinase","Other,kinases",3.669,3.693,0.024]
[303,"PIK-93","PI3Kgamma","NA",3.034,3.056,0.022]
[253,"XMD14-99","ALK,CDK7,LTK,others","NA",4.717,4.738,0.021]
[1530,"PFI-3","SMARCA2,SMARCA4,PB1","NA",4.755,4.776,0.021]
[1194,"SB505124","TGFBR1,ACVR1B,ACVR1C","RTK signaling",4.264,4.284,0.02]
[1494,"SN-38","TOP1","DNA synthesis",-4.112,-4.095,0.017]
[37,"Crizotinib","MET,ALK,ROS1","NA",2.906,2.923,0.017]
[150,"Bicalutamide","AR","NA",2.65,2.666,0.016]
[54,"CGP-082996","CDK4","NA",2.874,2.89,0.016]
[1241,"CHIR-99021","GSK3A,GSK3B","NA",3.835,3.851,0.016]
[1919,"Osimertinib","EGFR","EGFR signaling",1.969,1.983,0.015]
[1507,"Ruxolitinib","JAK1,JAK2","Other,kinases",5.028,5.043,0.015]
[119,"Lapatinib","ERBB2,EGFR","NA",1.935,1.949,0.014]
[1028,"VX-702","p38","NA",3.206,3.22,0.014]
[1512,"Cyclophosphamide","Alkylatingagent","DNA replication",5.44,5.454,0.014]
[1909,"Venetoclax","BCL2","Apoptosis regulation",2.292,2.305,0.013]
[1020,"Lenalidomide","CRBN","NA",4.015,4.028,0.013]
[1931,"MIRA-1","TP53","p53 pathway",5.746,5.758,0.012]
[286,"KIN001-236","Angiopoietin-1receptor","NA",4.692,4.703,0.011]
[256,"JW-7-24-1","LCK","NA",1.979,1.988,0.009]
[341,"Selisistat","SIRT1","NA",5.578,5.587,0.009]
[295,"NVP-BHG712","EPHB4","NA",3.577,3.583,0.006]
[374,"GSK1059615","PI3K","mTOR",-0.23,-0.226,0.004]
[1838,"Sinularin",null,"Unclassified",3.482,3.485,0.003]
[1031,"Elesclomol","HSP90","protein stability",-2.865,-2.87,-0.005]
[2171,"BMS-754807","IGF1R,IR","IGF1R signaling",1.896,1.891,-0.005]
[290,"KIN001-260","IKKB","NA",5.103,5.095,-0.008]
[279,"BIX02189","MEK5,ERK5","NA",4.726,4.715,-0.011]
[332,"XMD15-27","CAMK2","NA",4.859,4.848,-0.011]
[155,"Ponatinib","ABL,PDGFRA,VEGFR2,FGFR1,SRC,TIE2,FLT3","NA",0.839,0.826,-0.013]
[478,"LDN-193189","BMP","Other",0.891,0.878,-0.013]
[1011,"Navitoclax","BCL2,BCL-XL,BCL-W","Apoptosis regulation",1.772,1.757,-0.015]
[1024,"Lestaurtinib","FLT3,JAK2,NTRK1,NTRK2,NTRK3","NA",0.164,0.147,-0.017]
[1835,"Elephantin",null,"Unclassified",3.791,3.774,-0.017]
[211,"TL-2-105","notdefined","NA",4.229,4.212,-0.017]
[1377,"Afatinib","ERBB2,EGFR","NA",3.394,3.376,-0.018]
[275,"I-BET-762","BRD2,BRD3,BRD4","NA",4.403,4.385,-0.018]
[412,"Venotoclax","BCL-2selective","Apoptosis regulation",1.14,1.121,-0.019]
[254,"Quizartinib","FLT3","NA",2.357,2.338,-0.019]
[1910,"ABT737","BCL2,BCL-XL,BCL-W,BCL-B,BFL1","Apoptosis regulation",2.137,2.116,-0.021]
[310,"YM201636","PYKFYVE","NA",2.494,2.472,-0.022]
[206,"Ruxolitinib","JAK1,JAK2","NA",4.236,4.21,-0.026]
[106,"XMD8-85","ERK5,BET","NA",2.921,2.894,-0.027]
[312,"Tivozanib","VEGFR1,VEGFR2,VEGFR3","NA",0.458,0.427,-0.031]
[236,"IC-87114","PI3Kdelta","PI3K/MTOR signaling",5.17,5.134,-0.036]
[292,"Masitinib","KIT,PDGFRA,PDGFRB","NA",3.851,3.809,-0.042]
[17,"Cyclopamine","SMO","NA",4.93,4.868,-0.062]
[442,"IMD-0354","IKKb","Other,kinases",0.343,0.275,-0.068]
[153,"Midostaurin","PKC,PPK,FLT1,c-FGR,others","NA",0.218,0.145,-0.073]
[228,"AKT_inhibitor_VIII","AKT1,AKT2,AKT3","NA",2.645,2.563,-0.082]
[306,"Fedratinib","JAK2","NA",2.836,2.734,-0.102]
[1594,"OSI-027","MTORC1,MTORC2","PI3K/MTOR signaling",4.457,4.335,-0.122]
[165,"DMOG","HIF-PH","NA",6.667,6.493,-0.174]
[1131,"PRIMA-1MET","TP53activation","p53 pathway",4.888,4.7,-0.188]
[51,"Dasatinib","ABL,SRC,Ephrins,PDGFR,KIT","kinases",-0.765,-0.966,-0.201]
[94,"TGX221","PI3Kbeta","NA",3.233,3.02,-0.214]
[1079,"Dasatinib","ABL,SRC,Ephrins,PDGFR,KIT","Other,kinases",1.27,0.994,-0.276]