{"text_format":"3","workbook":"xlsx","n_sheets":20,"sheets":["LISTS","instruction","all enzymes","BL-3","Sheet2","Sheet3","Query","BL-4","BL-6","M.elsdenii","CPB6","M.hexanoica","Pseudoramibacter alactolyticus","Pseudoramibacter fermentans","other strains","RBO","iso-butyrate","Acrylate pathway","FAB","Sheet1"],"not_rendered":{"defined_names":1},"read":"whole","date_system":"1900"}

{"sheet":"LISTS","index":0,"n_rows":50,"n_cols":6,"rows_kept":50,"hidden":true}
[null,"chain elongation bacteria",{"$nulls":3},"TREE"]
[1,"Ruminococcaceae bacterium CPB6",{"$nulls":3},"Acetobacterium 1"]
[2,"Megasphaera elsdenii"]
[3,"Megasphaera hexanoica",{"$nulls":3},"Acetobacterium woodii DSM 1030"]
[4,"Pseudoramibacter alatolyticus"]
[5,"Candidatus Pseudoramibacter fermentans",{"$nulls":3},"Candidatus Weimeria 1"]
[]
[6,"Clostridium kluyveri",{"$nulls":3},"Weimeria bifida Weimeria bifida"]
[]
[7,"Caproiciproducens galactitolivorans (BS-1)",{"$nulls":3},"Caproiciproducens 2"]
[]
[8,"Eubacterium limosum",{"$nulls":3},"Caproiciproducens sp. NJN-50"]
[9,"Eubacterium pyruvativorans",{"$nulls":3},"Caproiciproducens galactitolivorans BS-1"]
[]
[10,"Candidatus Weimeria bifida",{"$nulls":3},"Clostridium 11"]
[]
[null,"Clostridium luticellarii DSM 29923",{"$nulls":3},"Clostridium acetobutylicum ATCC 824"]
[{"$nulls":5},"Clostridium kluyveri DSM 555"]
[{"$nulls":5},"Clostridium ljungdahlii ATCC 49587"]
[{"$nulls":5},"Clostridium acetobutylicum DSM 1731"]
[{"$nulls":5},"Clostridium acetobutylicum EA 2018"]
[{"$nulls":5},"Clostridium kluyveri NBRC 12016"]
[{"$nulls":5},"Clostridium tyrobutyricum DSM 2637"]
[{"$nulls":5},"Clostridium leptum CAG 27"]
[{"$nulls":5},"Clostridium luticellarii DSM 29923"]
[{"$nulls":5},"Clostridium jeddahense JCD"]
[{"$nulls":5},"Clostridium merdae Marseille-P2953"]
[]
[{"$nulls":5},"Eubacterium 2"]
[]
[{"$nulls":5},"Eubacterium pyruvativorans i6"]
[{"$nulls":5},"Eubacterium limosum 81C1"]
[]
[{"$nulls":5},"Megasphaera 2"]
[]
[{"$nulls":5},"Megasphaera elsdenii 14-14"]
[{"$nulls":5},"Megasphaera hexanoica MH"]
[]
[{"$nulls":5},"Pseudoramibacter 2"]
[]
[{"$nulls":5},"Pseudoramibacter alactolyticus ATCC 23263"]
[{"$nulls":5},"Pseudoramibacter fermentans Candidatus Pseudoram"]
[]
[{"$nulls":5},"Unset 5"]
[]
[{"$nulls":5},"Clostridium leptum DSM 753"]
[{"$nulls":5},"Ruminococcaceae bacterium CPB6"]
[{"$nulls":5},"Clostridiaceae BL-3"]
[{"$nulls":5},"Clostridiales BL-4"]
[{"$nulls":5},"Clostridiales BL-6"]

{"sheet":"instruction","index":1,"n_rows":12,"n_cols":2,"rows_kept":12,"merged":[[0,0,0,1]]}
["Additional file 4. Annotation summary of all chain-elogating strains"]
["Worksheet name","Description"]
["all enzymes","all enzymes involved in the functional annotation"]
["BL-3","predicted CDSs of the genome of strain BL-3"]
["BL-4","predicted CDSs of the genome of strain BL-4"]
["BL-6","predicted CDSs of the genome of strain BL-6"]
["M.elsdenii","predicted CDSs of the genome of strain Megasphaera elsdenii 14-14"]
["CPB6","predicted CDSs of the genome of strain Ruminococcaceae bacterium CPB6"]
["M.hexanoica","predicted CDSs of the genome of strain Megasphaera hexanoica MH"]
["Pseudoramibacter alactolyticus","predicted CDSs of the genome of strain Pseudoramibacter alactolyticus ATCC 23263"]
["Pseudoramibacter fermentans","predicted CDSs of the genome of strain Candidatus Pseudoramibacter fermentans"]
["other strains","predicted CDSs of the genome of other involved chain-elongating strains"]

{"sheet":"all enzymes","index":2,"n_rows":24,"n_cols":6,"rows_kept":24,"merged":[[1,0,6,0],[7,0,13,0],[14,0,15,0],[17,0,18,0],[19,0,23,0]]}
["Predicted function","No.","Enzyme abbreviation","EC number","Enzyme","Reaction"]
["Acetyl-CoA formation",1,"LacR","5.1.2.1","lactate racemase","D-lactate <=> L-lactate"]
[null,2,"LacP","2.A.14","lactate permease"]
[null,3,"LDH","1.1.1.27","lactate dehydrogenase","(S)-lactate + NAD+ → H+ + NADH + pyruvate"]
[null,4,"PFOR","1.2.7.1","pyruvate ferredoxin oxidoreductase","pyruvate + CoA + 2 oxidized ferredoxin → acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+"]
[null,5,"ADH","1.1.1.1","alcohol dehydrogenase","a primary alcohol + NAD+ → an aldehyde + NADH"]
[null,6,"ADA","1.2.1.10","acetaldehyde dehydrogenase","acetaldehyde + CoA + NAD+ → acetyl-CoA + NADH"]
["reverse β-oxidation",7,"ACAT","2.3.1.9, 2.3.1.16 ","acetyl-CoA acetyltransferase","2 acetyl-CoA → acetoacetyl-CoA + coenzyme A "]
[null,8,"HAD","1.1.1.157, 1.1.1.35","3-hydroxyacyl-CoA dehydrogenase","acetoacetyl-CoA + NADPH + H+ → (S)-3-hydroxybutyryl-CoA + NADP+ "]
[null,9,"ECH","4.2.1.150, 4.2.1.55","enoyl-CoA hydratase","(S)-3-hydroxybutyryl-CoA → crotonyl-CoA + H2O"]
[null,10,"BCD","1.3.8.1","butyryl-CoA dehydrogenase","crotonyl-CoA + a reduced electron-transfer flavoprotein → butyryl-CoA + an oxidized electron-transfer flavoprotein + H+"]
[null,11,"EtfAB",null,"electron transfer flavoprotein A,B"]
[null,12,"CoAT","2.8.3.-","butyryl-CoA:acetate CoA-transferase","acyl-CoA + acetate → a fatty acid anion + acetyl-CoA"]
[null,13,"ACT","3.1.2.20","acyl-CoA thioesterase","an acyl-CoA + H2O → a carboxylate + coenzyme A + H+"]
["Energy conservation",14,"RnfABCDEG","7.1.1.1","energy-converting NADH:ferredoxin oxidoreductase"]
[null,15,"EchABCDEF",null,"energy-conserving hydrogenase"]
["Hydrogen formation",16,"H2ase","1.12.7.2","hydrogen:ferredoxin oxidoreductase","2 reduced ferredoxin + 2 H+ → H2 + 2 oxidized ferredoxin "]
["Butyrate formation",17,"PTB","2.3.1.19","phosphate butyryltransferase","butyryl-CoA + phosphate → CoA + butyryl phosphate"]
[null,18,"BUK","2.7.2.7","butyrate kinase","ADP + butyryl phosphate → ATP + butyrate"]
["Others",19,"BM","5.4.99.13","butyryl-CoA:isobutyryl-CoA mutase","butyryl-CoA → iso-butyryl-CoA"]
[null,20,"ACOCT","2.8.3.19","acetyl-CoA:oxalate CoA-transferase","acetyl-CoA + oxalate → acetate + oxalyl-CoA"]
[null,21,"HadABC","4.2.1.157","(R)-2-hydroxyisocaproyl-CoA dehydratase activator, alpha subunit, beta subunit ","(R)-2-hydroxy-4-methylpentanoyl-CoA → 4-methylpent-2-enoyl-CoA + H2O"]
[null,22,"CarC","1.3.1.108","caffeyl-CoA reductase-Etf complex subunit CarC","hydrocaffeoyl-CoA + 2 NAD+ + 2 reduced [2Fe-2S]-[ferredoxin] → (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"]
[null,23,"HypCDEF",null,"hydrogenase maturation factor"]

{"sheet":"BL-3","index":3,"n_rows":159,"n_cols":10,"rows_kept":159,"merged":[[0,6,0,9]]}
["Reaction","EC number","Enzyme","Synonyms","CDS","Predicted products","Repeat regions"]
["Lactate oxidation to pyruvate"]
["L-lactate <->D-lactate","5.1.2.1","Lactate racemase",null,"CLOSBL3_v1_11086","Nickel-dependent lactate racemase"]
[{"$nulls":4},"CLOSBL3_v1_11116","lactate racemase","RPTR7039847"]
[{"$nulls":4},"CLOSBL3_v1_30024","Lactate racemase","RPTR7040044"]
[null,null,"lactate permease",null,"CLOSBL3_v1_11117","L-lactate permease"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"CLOSBL3_v1_10010","putative Lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL3_v1_10012","L-lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL3_v1_12309","putative Lactate dehydrogenase"]
[null,null,"Hydroxyacid dehydrogenase",null,"CLOSBL3_v1_10312","Hydroxyacid dehydrogenase","RPTR7039804"]
["Pyruvate conversion to acetyl-CoA"]
["pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+","1.2.7.1","pyruvate ferredoxin oxidoreductase",null,"CLOSBL3_v1_12188","Pyruvate:ferredoxin oxidoreductase, delta subunit"]
[null,null," ",null,"CLOSBL3_v1_12189","Pyruvate synthase subunit PorC"]
[{"$nulls":3},"pyruvate:ferredoxin oxidoreductase","CLOSBL3_v1_12417","Pyruvate:ferredoxin oxidoreductase"]
[{"$nulls":3},"pyruvate synthase","CLOSBL3_v1_12774","Pyruvate synthase subunit PorB"]
[{"$nulls":3},"pyruvate synthetase","CLOSBL3_v1_12775","Pyruvate synthase subunit PorA"]
[{"$nulls":4},"CLOSBL3_v1_12776","Pyruvate synthase subunit PorD"]
[{"$nulls":4},"CLOSBL3_v1_12777","Pyruvate synthase subunit PorC"]
[{"$nulls":3},"Pyruvate dehydrogenase complex repressor","CLOSBL3_v1_11994","Pyruvate dehydrogenase complex repressor"]
["pyruvate + CoA +  oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin + H+","1.2.7.1"," ","pyruvate flavodoxin oxidoreductase","CLOSBL3_v1_10343","Pyruvate-flavodoxin oxidoreductase"]
[{"$nulls":4},"CLOSBL3_v1_20129","Pyruvate-flavodoxin oxidoreductase","RPTR7039994","RPTR7039995"]
["Other acetyl-CoA formation"]
["ATP + a medium-chain fatty acid + CoA <=> AMP + diphosphate + a medium-chain acyl-CoA","6.2.1.-","acyl-CoA synthetase","Medium-chain acyl-CoA ligase","CLOSBL3_v1_12009","Acyl-CoA synthetase"]
["ATP + acetate + CoA = ADP + phosphate + acetyl-CoA","6.2.1.1",null,"Acetyl-CoA synthase","CLOSBL3_v1_20281","Bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase, subunit delta"]
[{"$nulls":4},"CLOSBL3_v1_20282","Acetyl-CoA synthase corrinoid iron-sulfur protein, large subunit"]
[{"$nulls":4},"CLOSBL3_v1_20284","Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha"]
["ATP + acetate <=> ADP + acetyl phosphate","2.7.2.1","acetate kinase",null,"CLOSBL3_v1_10746","acetate kinase"]
["CoA + acetyl phosphate = acetyl-CoA + phosphate ","2.3.1.8","phosphate acetyltransferase",null,"CLOSBL3_v1_10745","Phosphate acetyltransferase"]
["A primary alcohol + NAD(+) <=> an aldehyde + NADH","1.1.1.1","alcohol dehydrogenase","Alcohol dehydrogenase","CLOSBL3_v1_11881","Alcohol dehydrogenase","RPTR7039914"]
[{"$nulls":4},"CLOSBL3_v1_20137","Alcohol dehydrogenase"]
[{"$nulls":3},"Methanol dehydrogenase ","CLOSBL3_v1_10608","Methanol dehydrogenase activator","RPTR7039817","RPTR7039818"]
[null,"1.2.99.7","Aldehyde oxidoreductase","Aldehyde oxidoreductase","CLOSBL3_v1_11301","Aldehyde oxidoreductase","RPTR7039863"]
["Acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + NADH","1.2.1.10","acetaldehyde dehydrogenase","acetaldehyde dehydrogenase","CLOSBL3_v1_12484","putative acetaldehyde dehydrogenase","RPTR7039948","RPTR7039949"]
[{"$nulls":4},"CLOSBL3_v1_12496","putative acetaldehyde dehydrogenase","RPTR7039950"]
[{"$nulls":4},"CLOSBL3_v1_12732","Acetaldehyde dehydrogenase"]
[{"$nulls":4},"CLOSBL3_v1_10112","putative aldehyde dehydrogenase, ethanolamine utilization protein"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"CLOSBL3_v1_12838","Acetyl-CoA acetyltransferase"]
[{"$nulls":4},"CLOSBL3_v1_13111","Acetyl-CoA acetyltransferase"]
[{"$nulls":3},"acetoacetyl-CoA thiolase"]
[{"$nulls":3},"Acetoacetyl-CoA reductase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase","CLOSBL3_v1_11283","3-ketoacyl-CoA thiolase","RPTR7039862"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"CLOSBL3_v1_11276","Putative 3-hydroxybutyryl-CoA dehydrogenase"]
[{"$nulls":4},"CLOSBL3_v1_13113","3-hydroxybutyryl-CoA dehydrogenase"]
[{"$nulls":3},"beta-hydroxybutyryl-CoA dehydrogenase","CLOSBL3_v1_20313","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase","medium- and short-chain-3-hydroxyacyl-CoA dehydrogenase ","CLOSBL3_v1_12036","3-hydroxyacyl-CoA dehydrogenase"]
[{"$nulls":3},"3-hydroxy acid dehydrogenase","CLOSBL3_v1_20262","NADP-dependent 3-hydroxy acid dehydrogenase YdfG"]
[{"$nulls":3},"beta-hydroxy acid dehydrogenase","CLOSBL3_v1_10319","beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)","RPTR7039805"]
["(S)-3-hydroxybutanoyl-CoA <=> crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,"CLOSBL3_v1_13112","Short-chain-enoyl-CoA hydratase"]
[{"$nulls":3},"Short-chain-enoyl-CoA hydratase","CLOSBL3_v1_11087","putative Short-chain-enoyl-CoA hydratase","RPTR7039847"]
["a short-chain (3S)-3-hydroxyacyl-CoA <=> a short-chain trans-2,3-dehydroacyl-CoA + H2O","4.2.1.55"," ",null,"CLOSBL3_v1_20109","enoyl-CoA hydratase"]
[{"$nulls":4},"CLOSBL3_v1_20308","Short-chain-enoyl-CoA hydratase"]
[{"$nulls":4},"CLOSBL3_v1_12012","Caffeyl-CoA reductase-Etf complex subunit CarC"]
[{"$nulls":4},"CLOSBL3_v1_10853","Caffeyl-CoA reductase-Etf complex subunit CarC"]
[{"$nulls":3},"3-hydroxybutyryl-CoA dehydratase"]
[{"$nulls":3},"short-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase"," "]
[null,"4.2.1.17",null,null,"CLOSBL3_v1_13114","2-hydroxyisocaproyl-CoA dehydratase activator"]
[{"$nulls":4},"CLOSBL3_v1_13115","(R)-2-hydroxyisocaproyl-CoA dehydratase beta subunit"]
[{"$nulls":4},"CLOSBL3_v1_13116","(R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit","RPTR7039985"]
["crotonyl-CoA + a reduced electron-transfer flavoprotein <=> butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.99.-","acyl-CoA dehydrogenase",null,"CLOSBL3_v1_12502","Acyl-CoA dehydrogenase, short-chain specific","RPTR7039950","RPTR7039951"]
[null," "," ",null,"CLOSBL3_v1_11587","Acyl-CoA dehydrogenase, short-chain specific","RPTR7039891"]
[{"$nulls":4},"CLOSBL3_v1_12013","putative Acyl-CoA dehydrogenase"]
[null,"1.3.8.1","butyryl-CoA dehydrogenase",null,"CLOSBL3_v1_20310","butyryl-CoA dehydrogenase"]
[{"$nulls":3},"acyl-CoA reductase","CLOSBL3_v1_20108","Acyl-CoA reductase (LuxC)"]
[null,null,"electron transfer flavoprotein A,B","etf","CLOSBL3_v1_11114","Electron transfer flavoprotein, alpha subunit"]
[{"$nulls":4},"CLOSBL3_v1_11115","Electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"CLOSBL3_v1_11486","putative D-lactate dehydrogenase (acceptor)"]
[{"$nulls":4},"CLOSBL3_v1_11487","Electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"CLOSBL3_v1_11488","Electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"CLOSBL3_v1_12010","Electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"CLOSBL3_v1_12011","Electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"CLOSBL3_v1_20124","Electron transfer flavoprotein subunit beta","RPTR7039994"]
[{"$nulls":4},"CLOSBL3_v1_20125","Electron transfer flavoprotein subunit alpha","RPTR7039994"]
[{"$nulls":4},"CLOSBL3_v1_20126","FAD-binding oxidoreductase","RPTR7039994"]
[{"$nulls":4},"CLOSBL3_v1_20311","Electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"CLOSBL3_v1_20312","electron transfer flavoprotein (alpha subunit)"]
["Acyl-CoA + acetate <=> a fatty acid anion + acetyl-CoA","2.8.3.-","CoA transferase","butyryl-CoA:acetate CoA transferase","CLOSBL3_v1_13110","Butyryl-CoA:acetate CoA-transferase"]
[{"$nulls":3},"acyl-CoA transferase","CLOSBL3_v1_12724","4-hydroxybutyrate coenzyme A transferase","RPTR7039966","RPTR7039967","RPTR7039968"]
[{"$nulls":3},"cat2","CLOSBL3_v1_20114","4-hydroxybutyrate coenzyme A transferase"]
[{"$nulls":3},"cat1","CLOSBL3_v1_12353","propionyl-CoA:succinate-CoA transferase"]
["Butyryl-CoA conversion to butyrate"]
["an acyl-CoA + H2O → a carboxylate + coenzyme A + H+","3.1.2.20","acyl-CoA thioesterase","acyl coenzyme A hydrolase","CLOSBL3_v1_10147","Hydrolase (HAD superfamily), YqeK"]
[{"$nulls":3},"hydrolase","CLOSBL3_v1_10262","Hydrolase"]
[{"$nulls":4},"CLOSBL3_v1_10422","Hydrolase"]
[null,"3.1.2.18",null,"ADP-dependent short-chain-acyl-CoA hydrolase"," "]
[null,"3.1.2.19",null,"ADP-dependent medium-chain-acyl-CoA hydrolase"," "]
[{"$nulls":4},"CLOSBL3_v1_11169","Hydrolase"]
[{"$nulls":4},"CLOSBL3_v1_11170","Uncharacterized hydrolase YtnL"]
[{"$nulls":4},"CLOSBL3_v1_40030","Hydrolase"]
[{"$nulls":3},"acyl-CoA acylase (acyl coenzyme A acylase)","CLOSBL3_v1_20113","conserved protein of unknown function"]
[null,"3.1.1.1",null,"acyl coenzyme A thioesterase","CLOSBL3_v1_10239","Esterase TesA","RPTR7039799","RPTR7039800","RPTR7039801","RPTR7039802"]
[{"$nulls":4},"CLOSBL3_v1_10819","GDSL-like Lipase/Acylhydrolase","RPTR7039822","RPTR7039823"]
[{"$nulls":4},"CLOSBL3_v1_10947","protein of unknown function","RPTR7039837"]
[]
[{"$nulls":4},"CLOSBL3_v1_12994","Fluoroacetyl-CoA thioesterase"]
[{"$nulls":4},"CLOSBL3_v1_13086","Acyl-ACP thioesterase","RPTR7039983","RPTR7039984"]
[{"$nulls":4},"CLOSBL3_v1_40057","Acyl-ACP thioesterase","RPTR7040055","RPTR7040056"]
["butanoyl-CoA + phosphate = CoA + butanoyl phosphate","2.3.1.19","phosphate butyryltransferase",null,"CLOSBL3_v1_11711","phosphate BCFA and butyryl coenzyme A transferase","RPTR7039896"]
[{"$nulls":4},"CLOSBL3_v1_12016","Phosphate butyryltransferase","RPTR7039931"]
[{"$nulls":4},"CLOSBL3_v1_12308","Phosphate butyryltransferase"]
["ADP + butanoyl phosphate <=> ATP + butanoate","2.7.2.7","butyrate kinase",null,"CLOSBL3_v1_11710","Butyrate kinase","RPTR7039896"]
[{"$nulls":4},"CLOSBL3_v1_20086","Butyrate kinase"]
[{"$nulls":4},"CLOSBL3_v1_20087","Butyrate kinase"]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfC","CLOSBL3_v1_10629","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C","RPTR7039820"]
[{"$nulls":3},"rnfD","CLOSBL3_v1_10630","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D","RPTR7039820"]
[{"$nulls":3},"rnfG","CLOSBL3_v1_10631","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G","RPTR7039820"]
[{"$nulls":3},"rnfE","CLOSBL3_v1_10632","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E","RPTR7039820"]
[{"$nulls":3},"rnfB","CLOSBL3_v1_10634","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[{"$nulls":3},"rnfA","CLOSBL3_v1_10633","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":4},"CLOSBL3_v1_10113","Electron transport complex subunit RsxC"]
[{"$nulls":4},"CLOSBL3_v1_11463","Iron-sulfur cluster-binding protein"]
[{"$nulls":4},"CLOSBL3_v1_11953","Ferredoxin","RPTR7039922","RPTR7039923"]
[{"$nulls":4},"CLOSBL3_v1_12045","Ferredoxin"]
[{"$nulls":4},"CLOSBL3_v1_12488","Electron transport complex protein RnfC","RPTR7039948","RPTR7039949"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]
[null,null,"ATPase",null,"CLOSBL3_v1_12829","F1F0 ATPase, subunit C (epsilon chain)"]
[{"$nulls":4},"CLOSBL3_v1_12830","ATP synthase (subunit beta, component F1)"]
[{"$nulls":4},"CLOSBL3_v1_12831","ATP synthase gamma chain (F1Fo ATPase, subunit G)"]
[{"$nulls":4},"CLOSBL3_v1_12832","ATP synthase (subunit alpha, component F1)"]
[{"$nulls":4},"CLOSBL3_v1_12833","ATP synthase subunit delta"]
[{"$nulls":4},"CLOSBL3_v1_12834","ATP synthase subunit b"]
[{"$nulls":4},"CLOSBL3_v1_12835","ATP synthase (subunit c, component F0)"]
[{"$nulls":4},"CLOSBL3_v1_12836","ATP synthase subunit a"]
[{"$nulls":4},"CLOSBL3_v1_12837","ATPase subunit I"]
["H2 formation"]
["H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+",null,"hydrogen:ferredoxin oxidoreductase","ferredoxin hydrogenase","CLOSBL3_v1_10096","Electron transport protein HydN","RPTR7039793"]
[null,"1.12.7.2","H2ase","Periplasmic (Fe) hydrogenase","CLOSBL3_v1_10095","Periplasmic (Fe) hydrogenase large subunit","RPTR7039793"]
[{"$nulls":4},"CLOSBL3_v1_13020","ferredoxin hydrogenase"]
[{"$nulls":4},"CLOSBL3_v1_20317","putative ferredoxin hydrogenase"]
[{"$nulls":4},"CLOSBL3_v1_10094","Electron transport protein HydN","RPTR7039793"]
["H(2) + NADP(+) <=> H(+) + NADPH","1.1.12.3","hydrogen:NADP+ oxidoreductase","HndC","CLOSBL3_v1_10092","NADP-reducing hydrogenase subunit HndC"]
[{"$nulls":3},"HndA","CLOSBL3_v1_10091","NADP-reducing hydrogenase subunit HndA"]
[{"$nulls":3},"HndD","CLOSBL3_v1_10093","putative NADP-reducing hydrogenase subunit HndD"]
[{"$nulls":4},"CLOSBL3_v1_20400","putative NAD(P)-dependent dehydrogenase","RPTR7040019","RPTR7040020"]
["2 H2 + NAD+ + 2 oxidized ferredoxin = 5 H+ + NADH + 2 reduced ferredoxin","1.12.1.4","bifurcating [Fe-Fe] hydrogenase","HydABC (electron confurcation)","CLOSBL3_v1_12063","[FeFe] hydrogenase maturase subunit HydE","RPTR7039932"]
[null,null,"HydABC",null,"CLOSBL3_v1_12064","Iron-only hydrogenase system regulator","RPTR7039932"]
["NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster = NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster","1.6.1.4","NADH:NADP+, ferredoxin oxidoreductase",null,"CLOSBL3_v1_20314","putative NADH-dependent reduced ferredoxin:NADP+ oxidoreductase,subunit alpha"]
["Lactate conversion to iso-butyrate"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"CLOSBL3_v1_10010","putative Lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL3_v1_10012","L-lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL3_v1_12309","putative Lactate dehydrogenase"]
["ATP + pyruvate + HCO(3)(-) <=> ADP + phosphate + oxaloacetate","6.4.1.1","pyruvate carboxylase","pyruvate:carbon-dioxide ligase","CLOSBL3_v1_20297","pyruvate carboxylase","RPTR7040001","RPTR7040002"]
["oxaloacetate + NADH <=> (S)-malate + NAD(+) ","1.1.1.37","malate dehydrogenase",null,"CLOSBL3_v1_10016","Malate dehydrogenase"]
["(S)-malate <=> fumarate + H2O","4.2.1.2","fumarate hydratase","fumarase","CLOSBL3_v1_12516","Fumarate hydratase class II"]
["fumarate + a quinol <=> succinate + a quinone","1.3.5.1","succinate dehydrogenase"]
["fumarate + NADH + H+ <=> succinate + NAD+","1.3.1.6","fumarate reductase"]
["GTP + succinate + CoA <=> GDP + phosphate + succinyl-CoA","6.2.1.4","succinyl-CoA synthetase","succinyl-CoA ligase"]
["succinyl-CoA <=> (R)-methylmalonyl-CoA","5.4.99.2","methylmalonyl-CoA mutase",null,"CLOSBL3_v1_12531","fragment of methylmalonyl-CoA mutase (part 2)"]
[{"$nulls":4},"CLOSBL3_v1_12532","fragment of methylmalonyl-CoA mutase (part 1)"]
["ADP + phosphate + (S)-methylmalonyl-CoA <=> ATP + propanoyl-CoA + HCO3-","6.4.1.3","propionyl-CoA carboxylase",null,"CLOSBL3_v1_12348","putative propionyl-CoA carboxylase beta chain"]
["(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA","5.1.99.1","methylmalonyl-CoA epimerase",null,"CLOSBL3_v1_12349","methylmalonyl-CoA epimerase"]
["(S)-methylmalonyl-CoA + pyruvate <=> propanoyl-CoA + oxaloacetate","2.1.3.1","methylmalonyl-CoA: pyruvate carboxytransferase"]
["propanoyl-CoA + HCO3- + NADH <=> 2-methyl-3-oxopropanoate + CoA + H2O + NAD+","1.2.1.27","methylmalonate-semialdehyde dehydrogenase"]
["2-methyl-3-oxopropanoate + NADH + H+  <=> 3-hydroxy-iosbutyrate + NAD+","1.1.1.31","3-hydroxyisobutyrate dehydrogenase"]
["CoA + 3-hydroxy-iosbutyrate <=> 3-hydroxy-iosbutyryl-CoA + H2O","3.1.2.4","3-hydroxyisobutyryl-CoA hydrolase"]
["3-hydroxy-iosbutyryl-CoA <=> 3-enoyl-isobutyryl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase"]
["3-enoyl-isobutyryl-CoA + a reduced electron-transfer flavoprotein <=> iso-butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase"]
["iso-butanoyl-CoA + succinate <=> succinyl-CoA + iso-butyrate","2.8.3.-","CoA transferase"]

{"sheet":"Sheet2","index":4,"n_rows":4,"n_cols":11,"rows_kept":4,"hidden":true}
["MaGe"]
[]
["Sequence","Id","Type","Strand","Begin1","End1","Length1","Begin2","End2","Length2","Ident %"]
[null,"RPT122877554","Distant","D",3733147,3734486,1340,3606603,3607948,1346,73.551]

{"sheet":"Sheet3","index":5,"n_rows":0,"n_cols":0,"rows_kept":0,"hidden":true}

{"sheet":"Query","index":6,"n_rows":3,"n_cols":2,"rows_kept":3,"hidden":true}
[1,"Swiss Prot EXP"]
[2,"PRIAM EC prediction"]
[3,"DataBank/Automatic annotations"]

{"sheet":"BL-4","index":7,"n_rows":134,"n_cols":8,"rows_kept":134,"merged":[[0,6,0,9]]}
["Reaction","EC number","Enzyme","Synonyms","CDS","Predicted products","Repeat regions"]
["Lactate oxidation to pyruvate"]
["L-lactate <->D-lactate","5.1.2.1","Lactate racemase"]
[null,null,"lactate permease"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"CLOSBL4_v1_0061","L-lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL4_v1_0433","Putative L-lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL4_v1_1444","L-lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL4_v1_2205","L-lactate dehydrogenase","RPTR7040153","RPTR7040154"]
["Pyruvate conversion to acetyl-CoA"]
["pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+","1.2.7.1","pyruvate ferredoxin oxidoreductase","Pyruvate:ferredoxin oxidoreductase","CLOSBL4_v1_0841","Pyruvate:ferredoxin oxidoreductase"]
[null,null," ","pyruvate synthase"]
[{"$nulls":3},"pyruvate synthetase"," "]
[]
["pyruvate + CoA +  oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin + H+"," ",null,"pyruvate flavodoxin oxidoreductase"]
["Other acetyl-CoA formation"]
["ATP + acetate + CoA = ADP + phosphate + acetyl-CoA","6.2.1.1","acetyl-CoA synthetase","CoA ligase","CLOSBL4_v1_0048","Long-chain-fatty-acid--CoA ligase"]
[{"$nulls":3},"Acetyl-CoA synthase"]
["ATP + acetate <=> ADP + acetyl phosphate","2.7.2.1","acetate kinase","acetate kinase","CLOSBL4_v1_2217","Acetate kinase"]
["CoA + acetyl phosphate = acetyl-CoA + phosphate ","2.3.1.8","phosphate acetyltransferase","phosphotransacetylase","CLOSBL4_v1_2331","phosphotransacetylase"]
["A primary alcohol + NAD(+) <=> an aldehyde + NADH","1.1.1.1","alcohol dehydrogenase","Alcohol dehydrogenase","CLOSBL4_v1_2290","Alcohol dehydrogenase"]
[{"$nulls":3},"Methanol dehydrogenase "]
[null,"1.2.99.7","Aldehyde oxidoreductase","Aldehyde oxidoreductase"]
["Acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + NADH","1.2.1.10","acetaldehyde dehydrogenase","acetaldehyde dehydrogenase"]
[{"$nulls":3},"acetaldehyde-CoA dehydrogenase"]
[{"$nulls":3},"aldehyde dehydrogenase","CLOSBL4_v1_0542","N-acetylglutamate gamma-semialdehyde dehydrogenase"]
[{"$nulls":4},"CLOSBL4_v1_0474","glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)"]
[{"$nulls":4},"CLOSBL4_v1_1950","Aspartate-semialdehyde dehydrogenase"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"CLOSBL4_v1_1867","acetyl-CoA acetyltransferase"]
[{"$nulls":4},"CLOSBL4_v1_1159","Acetyl-CoA acetyltransferase"]
[{"$nulls":3},"acetoacetyl-CoA thiolase"," "]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"CLOSBL4_v1_1158","3-hydroxybutyryl-CoA dehydrogenase"]
[{"$nulls":4},"CLOSBL4_v1_1869","3-hydroxybutyryl-CoA dehydrogenase"]
[]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null," "]
[{"$nulls":3},"3-hydroxy acid dehydrogenase","CLOSBL4_v1_0845","Hydroxyacid dehydrogenase"]
[{"$nulls":3},"beta-hydroxy acid dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,"CLOSBL4_v1_1161","Short-chain-enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O","4.2.1.55"," ",null,"CLOSBL4_v1_1868","Short-chain-enoyl-CoA hydratase"]
[]
[{"$nulls":3},"3-hydroxybutyryl-CoA dehydratase"]
[{"$nulls":4},"CLOSBL4_v1_1804","2-hydroxyacyl-CoA dehydratase"]
[{"$nulls":4},"CLOSBL4_v1_1801","2-hydroxyacyl-CoA dehydratase"]
[{"$nulls":4},"CLOSBL4_v1_1163","(R)-2-hydroxyisocaproyl-CoA dehydratase activator"]
[{"$nulls":4},"CLOSBL4_v1_1164","(R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit"]
[{"$nulls":4},"CLOSBL4_v1_1165","(R)-2-hydroxyisocaproyl-CoA dehydratase beta subunit"]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"CLOSBL4_v1_2140","Butyryl-CoA dehydrogenase"]
[{"$nulls":4},"CLOSBL4_v1_1870","Butyryl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase"]
[{"$nulls":3},"acyl-CoA reductase"]
[null,null,"electron transfer flavoprotein A,B",null,"CLOSBL4_v1_2141","Flavoprotein"]
[{"$nulls":3},"etf","CLOSBL4_v1_1871","Electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"CLOSBL4_v1_1872","Electron transfer flavoprotein subunit alpha"]
[{"$nulls":3},"FAD-dependent oxidoreductase","CLOSBL4_v1_0940","FAD-dependent oxidoreductase"]
[{"$nulls":4},"CLOSBL4_v1_2223","FAD-dependent oxidoreductase"]
[{"$nulls":4},"CLOSBL4_v1_2264","FAD-dependent oxidoreductase"]
[{"$nulls":3},"FAD-binding oxidoreductase"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","butyryl-CoA:acetate CoA transferase","CLOSBL4_v1_1873","Butyryl-CoA:acetate CoA-transferase"]
["Formyl-CoA + oxalate = formate + oxalyl-CoA",{"$nulls":3},"CLOSBL4_v1_1160","putative Acetyl-CoA:oxalate CoA-transferase"]
[{"$nulls":3},"acyl-CoA transferase","CLOSBL4_v1_1162","Putative acyl-CoA transferase"]
["Butyryl-CoA conversion to butyrate"]
["acyl-CoA + H2O = CoA + a carboxylate","3.1.2.20","acyl-CoA hydrolase","acyl coenzyme A hydrolase","CLOSBL4_v1_1628","BAAT / Acyl-CoA thioester hydrolase C terminal"]
[{"$nulls":3},"hydrolase","CLOSBL4_v1_0059","Hydrolase"]
[{"$nulls":4},"CLOSBL4_v1_0951","Hydrolase"]
[{"$nulls":4},"CLOSBL4_v1_1108","Alpha/beta hydrolase"]
[{"$nulls":4},"CLOSBL4_v1_1170","Alpha/beta hydrolase family protein"]
[{"$nulls":4},"CLOSBL4_v1_1214","Alpha/beta hydrolase"]
[{"$nulls":4},"CLOSBL4_v1_1247","putative Alpha/beta hydrolase"]
[{"$nulls":4},"CLOSBL4_v1_1692","Hydrolase"]
[{"$nulls":4},"CLOSBL4_v1_2095","Alpha/beta hydrolase"]
[{"$nulls":4},"CLOSBL4_v1_2232","Hydrolase"]
[{"$nulls":3},"acyl-CoA acylase (acyl coenzyme A acylase)"," "]
[null,"3.1.1.1","acyl-CoA thioesterase","acyl coenzyme A thioesterase","CLOSBL4_v1_1443","putative acyl-CoA thioesterase"]
[{"$nulls":3},"Acylhydrolase"]
[null,"3.1.2.18",null,"ADP-dependent short-chain-acyl-CoA hydrolase"," "]
[null,"3.1.2.19",null,"ADP-dependent medium-chain-acyl-CoA hydrolase"," "]
["butanoyl-CoA + phosphate = CoA + butanoyl phosphate","2.3.1.19","phosphate butyryltransferase"]
["ADP + butanoyl phosphate <=> ATP + butanoate","2.7.2.7","butyrate kinase"]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfC","CLOSBL4_v1_2199","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[{"$nulls":3},"rnfD","CLOSBL4_v1_2200","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfG","CLOSBL4_v1_2201","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfE","CLOSBL4_v1_2202","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfA","CLOSBL4_v1_2203","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfB","CLOSBL4_v1_2204","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"," "]
[null,null,"ATPase",null,"CLOSBL4_v1_0901","V-type ATP synthase subunit D"]
[{"$nulls":4},"CLOSBL4_v1_0902","V-type ATP synthase beta chain"]
[{"$nulls":4},"CLOSBL4_v1_0903","V-type ATP synthase alpha chain"]
[{"$nulls":4},"CLOSBL4_v1_0904","V-type ATP synthase subunit F"]
[{"$nulls":4},"CLOSBL4_v1_0905","V-type ATP synthase subunit C"]
[{"$nulls":4},"CLOSBL4_v1_0906","V-type proton ATPase subunit E"]
[{"$nulls":4},"CLOSBL4_v1_0907","V-type sodium ATPase, K subunit"]
[{"$nulls":4},"CLOSBL4_v1_0908","V-type ATP synthase subunit I"]
[{"$nulls":4},"CLOSBL4_v1_0909","V-type sodium ATP synthase subunit G"]
[{"$nulls":4},"CLOSBL4_v1_1448","V-type ATP synthase subunit D"]
[{"$nulls":4},"CLOSBL4_v1_1449","V-type ATP synthase beta chain"]
[{"$nulls":4},"CLOSBL4_v1_1450","V-type ATP synthase alpha chain"]
[{"$nulls":4},"CLOSBL4_v1_1451","V-type proton ATPase subunit E"]
[{"$nulls":4},"CLOSBL4_v1_1452","V-type ATP synthase subunit F"]
[{"$nulls":4},"CLOSBL4_v1_1453","V-type ATP synthase subunit C"]
[{"$nulls":4},"CLOSBL4_v1_1454","putative V-type ATP synthase subunit I"]
[{"$nulls":4},"CLOSBL4_v1_1455","putative V-type ATP synthase subunit C"]
["H2 formation"]
["H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+","1.12.7.2","hydrogen:ferredoxin oxidoreductase","Periplasmic (Fe) hydrogenase","CLOSBL4_v1_2149","putative Ferredoxin hydrogenase"]
[null,null,"H2ase","ferredoxin hydrogenase"]
["H(2) + NADP(+) <=> H(+) + NADPH","1.1.12.3","hydrogen:NADP+ oxidoreductase",null,"CLOSBL4_v1_0994","putative NADPH-Fe(3+) oxidoreductase subunit beta"]
[{"$nulls":3},"HndC","CLOSBL4_v1_0995","NADP-reducing hydrogenase subunit HndC"]
["2 H2 + NAD+ + 2 oxidized ferredoxin = 5 H+ + NADH + 2 reduced ferredoxin","1.12.1.4","bifurcating [Fe-Fe] hydorgenase","HydABC (electron confurcation)"]
[null,null,"HydABC"]
["NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster = NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster","1.6.1.4","NADH:NADP+, ferredoxin oxidoreductase"]
["Lactate conversion to iso-butyrate"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"CLOSBL4_v1_0061","L-lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL4_v1_0433","Putative L-lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL4_v1_1444","L-lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL4_v1_2205","L-lactate dehydrogenase","RPTR7040153","RPTR7040154"]
["pyruvate + CO2 + NADH <=> (S)-malate + NAD+","1.1.1.38","malate dehydrogenase",null,"CLOSBL4_v1_0973","malate dehydrogenase"]
[]
["(S)-malate <=> fumarate + H2O","4.2.1.2","fumarate hydratase","fumarase","CLOSBL4_v1_0089","putative fumarate hydratase"]
["fumarate + a quinol <=> succinate + a quinone","1.3.5.1","succinate dehydrogenase",null,"CLOSBL4_v1_1789","putative succinate dehydrogenase"]
["fumarate + NADH + H+ <=> succinate + NAD+","1.3.1.6","fumarate reductase"]
["GTP + succinate + CoA <=> GDP + phosphate + succinyl-CoA","6.2.1.4","succinyl-CoA synthetase","succinyl-CoA ligase"]
["succinyl-CoA <=> (R)-methylmalonyl-CoA","5.4.99.2","methylmalonyl-CoA mutase"]
[]
["ADP + phosphate + (S)-methylmalonyl-CoA <=> ATP + propanoyl-CoA + HCO3-","6.4.1.3","propionyl-CoA carboxylase"]
["(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA","5.1.99.1","methylmalonyl-CoA epimerase"]
["(S)-methylmalonyl-CoA + pyruvate <=> propanoyl-CoA + oxaloacetate","2.1.3.1","methylmalonyl-CoA: pyruvate carboxytransferase"]
["propanoyl-CoA + HCO3- + NADH <=> 2-methyl-3-oxopropanoate + CoA + H2O + NAD+","1.2.1.27","methylmalonate-semialdehyde dehydrogenase"]
["2-methyl-3-oxopropanoate + NADH + H+  <=> 3-hydroxy-iosbutyrate + NAD+","1.1.1.31","3-hydroxyisobutyrate dehydrogenase"]
["CoA + 3-hydroxy-iosbutyrate <=> 3-hydroxy-iosbutyryl-CoA + H2O","3.1.2.4","3-hydroxyisobutyryl-CoA hydrolase"]
["3-hydroxy-iosbutyryl-CoA <=> 3-enoyl-isobutyryl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase"]
["3-enoyl-isobutyryl-CoA + a reduced electron-transfer flavoprotein <=> iso-butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase"]
["iso-butanoyl-CoA + succinate <=> succinyl-CoA + iso-butyrate","2.8.3.-","CoA transferase"]

{"sheet":"BL-6","index":8,"n_rows":148,"n_cols":9,"rows_kept":148,"merged":[[0,6,0,9]]}
["Reaction","EC number","Enzyme","Synonyms","CDS","Predicted products","Repeat regions"]
["Lactate oxidation to pyruvate"]
["L-lactate <->D-lactate","5.1.2.1","Lactate racemase",null,"CLOSBL6_v1_3221","Lactate racemase","RPTR7040412","RPTR7040413"]
[null,null,"lactate permease",null,"CLOSBL6_v1_3223","L-lactate permease","RPTR7040412","RPTR7040413"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"CLOSBL6_v1_0169","Lactate dehydrogenase"]
[{"$nulls":4},"CLOSBL6_v1_3220","L-lactate, D-lactate, and/or glycolate dehydrogenase","RPTR7040412","RPTR7040413"]
[{"$nulls":4},"CLOSBL6_v1_2713","L-lactate dehydrogenase","RPTR7040360","RPTR7040361"]
[{"$nulls":4},"CLOSBL6_v1_2744","Hydroxyacid dehydrogenase","RPTR7040364","RPTR7040365"]
[{"$nulls":4},"CLOSBL6_v1_2953","(R)-2-hydroxyacid dehydrogenase, similar to L-sulfolactate dehydrogenase"]
["Pyruvate conversion to acetyl-CoA"]
["pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+","1.2.7.1","pyruvate ferredoxin oxidoreductase",null,"CLOSBL6_v1_0279","Pyruvate:ferredoxin oxidoreductase"]
[null,null," ","pyruvate synthase","CLOSBL6_v1_3009","Pyruvate synthase subunit PorC","RPTR7040390","RPTR7040391","RPTR7040392"]
[{"$nulls":4},"CLOSBL6_v1_3010","Pyruvate synthase subunit PorD","RPTR7040391","RPTR7040392"]
[{"$nulls":4},"CLOSBL6_v1_3011","Pyruvate synthase subunit PorA","RPTR7040391","RPTR7040392"]
[{"$nulls":4},"CLOSBL6_v1_3012","Pyruvate synthase subunit PorB","RPTR7040392"]
[{"$nulls":3},"pyruvate synthetase"," "]
["pyruvate + CoA +  oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin + H+","1.2.7.-"," ","pyruvate flavodoxin oxidoreductase"," "]
["Other acetyl-CoA formation"]
["ATP + acetate + CoA = ADP + phosphate + acetyl-CoA","6.2.1.1","acetyl-CoA synthetase","CoA ligase","CLOSBL6_v1_2513","3-hydroxybenzoate--CoA/4-hydroxybenzoate--CoA ligase"]
[{"$nulls":3},"Acetyl-CoA synthase"]
["ATP + acetate <=> ADP + acetyl phosphate","2.7.2.1","acetate kinase","acetate kinase","CLOSBL6_v1_2260","acetate kinase"]
["CoA + acetyl phosphate = acetyl-CoA + phosphate ","2.3.1.8","phosphate acetyltransferase","phosphotransacetylase","CLOSBL6_v1_1872","Phosphate acetyltransferase"]
["A primary alcohol + NAD(+) <=> an aldehyde + NADH","1.1.1.1","alcohol dehydrogenase","Alcohol dehydrogenase","CLOSBL6_v1_0095","Alcohol dehydrogenase","RPTR7040161"]
[{"$nulls":4},"CLOSBL6_v1_1002","Zn-dependent alcohol dehydrogenase","RPTR7040251"]
[{"$nulls":4},"CLOSBL6_v1_1804","Alcohol dehydrogenase"]
[{"$nulls":4},"CLOSBL6_v1_2186","fused acetaldehyde-CoA dehydrogenase "]
[{"$nulls":5},"iron-dependent alcohol dehydrogenase "]
[{"$nulls":4},"CLOSBL6_v1_2512","Alcohol dehydrogenase"]
[{"$nulls":4},"CLOSBL6_v1_2879","Alcohol dehydrogenase","RPTR7040374"]
[{"$nulls":4},"CLOSBL6_v1_3434","Alcohol dehydrogenase","RPTR7040428","RPTR7040429"]
[{"$nulls":3},"Methanol dehydrogenase "]
[null,"1.2.99.7","Aldehyde oxidoreductase","Aldehyde oxidoreductase","CLOSBL6_v1_2731","Short-chain dehydrogenase","RPTR7040362"]
["Acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + NADH","1.2.1.10","acetaldehyde dehydrogenase","acetaldehyde dehydrogenase"]
[{"$nulls":3},"acetaldehyde-CoA dehydrogenase"," "]
[{"$nulls":3},"aldehyde dehydrogenase","CLOSBL6_v1_0723","glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)","RPTR7040214"]
[{"$nulls":4},"CLOSBL6_v1_1351","putative Aldehyde dehydrogenase"]
[{"$nulls":4},"CLOSBL6_v1_1712","Aspartate-semialdehyde dehydrogenase"]
[{"$nulls":4},"CLOSBL6_v1_3343","N-acetylglutamate gamma-semialdehyde dehydrogenase"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"CLOSBL6_v1_0127","Acetyl-CoA acetyltransferase"]
[{"$nulls":4},"CLOSBL6_v1_0556","Acetyl-CoA acetyltransferase","RPTR7040196","RPTR7040197"]
[{"$nulls":3},"Acetoacetyl-CoA reductase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"CLOSBL6_v1_0126","3-hydroxybutyryl-CoA dehydrogenase"]
[{"$nulls":4},"CLOSBL6_v1_0555","3-hydroxybutyryl-CoA dehydrogenase","RPTR7040196","RPTR7040197"]
[{"$nulls":4},"CLOSBL6_v1_0871","3-hydroxybutyryl-CoA dehydrogenase"]
[{"$nulls":3},"beta-hydroxybutyryl-CoA dehydrogenase"," "]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase","medium- and short-chain-3-hydroxyacyl-CoA dehydrogenase "," "]
[{"$nulls":3},"3-hydroxy acid dehydrogenase","CLOSBL6_v1_2744","Hydroxyacid dehydrogenase","RPTR7040364","RPTR7040365"]
[{"$nulls":3},"beta-hydroxy acid dehydrogenase","CLOSBL6_v1_2953","putative Malate/L-lactate dehydrogenases"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,"CLOSBL6_v1_0031","putative Enoyl-CoA hydratase","RPTR7040157","RPTR7040158"]
[null,"4.2.1.55"," ",null,"CLOSBL6_v1_0558","Short-chain-enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
[{"$nulls":3},"4-hydroxybutyryl-CoA dehydratase","CLOSBL6_v1_1014","4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase"]
[]
[{"$nulls":3},"2-hydroxyisocaproyl-CoA","CLOSBL6_v1_0560","2-hydroxyisocaproyl-CoA dehydratase activator"]
[{"$nulls":4},"CLOSBL6_v1_0561","(R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit"]
[{"$nulls":4},"CLOSBL6_v1_0562","(R)-2-hydroxyisocaproyl-CoA dehydratase beta subunit"]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"CLOSBL6_v1_1904","Butyryl-CoA dehydrogenase","RPTR7040311","RPTR7040312","RPTR7040313"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,"CLOSBL6_v1_3062","Acyl-CoA dehydrogenase, short-chain specific","RPTR7040398"]
[{"$nulls":4},"CLOSBL6_v1_0135","acyl-CoA dehydrogenase","RPTR7040162"]
[{"$nulls":4},"CLOSBL6_v1_3216","acyl-CoA dehydrogenase","RPTR7040412","RPTR7040413"]
[{"$nulls":3},"acyl-CoA reductase"]
[null,null,"electron transfer flavoprotein A,B","etf","CLOSBL6_v1_0136","Electron transfer flavoprotein subunit beta","RPTR7040162"]
[{"$nulls":4},"CLOSBL6_v1_0137","Electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"CLOSBL6_v1_2820","Electron transfer flavoprotein subunit alpha","RPTR7040368","RPTR7040369","RPTR7040370"]
[{"$nulls":4},"CLOSBL6_v1_2821","Electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"CLOSBL6_v1_3217","Electron transfer flavoprotein subunit alpha","RPTR7040412","RPTR7040413"]
[{"$nulls":4},"CLOSBL6_v1_3218","Electron transfer flavoprotein subunit beta"]
[]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","CLOSBL6_v1_0559","Putative acyl-CoA transferase"]
[{"$nulls":3},"butyryl-CoA:acetate CoA transferase","CLOSBL6_v1_0131","Glutaconyl-CoA decarboxylase subunit gamma"]
[{"$nulls":4},"CLOSBL6_v1_0132","Glutaconyl-CoA decarboxylase subunit alpha"]
[{"$nulls":4},"CLOSBL6_v1_0133","4-hydroxybutyrate coenzyme A transferase","RPTR7040162"]
[{"$nulls":4},"CLOSBL6_v1_0134","methylglutaconyl-CoA hydratase (leucine degradation)"]
[{"$nulls":4},"CLOSBL6_v1_1016","4-hydroxybutyrate coenzyme A transferase"]
["Butyryl-CoA conversion to butyrate"]
["acyl-CoA + H2O = CoA + a carboxylate","3.1.2.20","acyl-CoA hydrolase","acyl coenzyme A hydrolase"]
[{"$nulls":3},"hydrolase"]
[{"$nulls":3},"acyl-CoA acylase (acyl coenzyme A acylase)"]
[null,"3.1.1.1","acyl-CoA thioesterase","acyl coenzyme A thioesterase","CLOSBL6_v1_2270","putative acyl-CoA thioesterase"]
[{"$nulls":3},"Acylhydrolase"]
[{"$nulls":3},"thioesterase","CLOSBL6_v1_3414","Thioesterase","RPTR7040427"]
[{"$nulls":4},"CLOSBL6_v1_3495","Acyl-ACP thioesterase","RPTR7040433","RPTR7040434"]
[null,"3.1.2.18",null,"ADP-dependent short-chain-acyl-CoA hydrolase"]
[null,"3.1.2.19",null,"ADP-dependent medium-chain-acyl-CoA hydrolase"]
["butanoyl-CoA + phosphate = CoA + butanoyl phosphate","2.3.1.19","phosphate butyryltransferase"]
["ADP + butanoyl phosphate <=> ATP + butanoate","2.7.2.7","butyrate kinase"]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase",null,"CLOSBL6_v1_3464","conserved exported protein of unknown function"]
[{"$nulls":3},"rnfA","CLOSBL6_v1_3465","putative Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfE","CLOSBL6_v1_3466","putative Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfD","CLOSBL6_v1_3467","putative Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfC","CLOSBL6_v1_3468","putative Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[{"$nulls":4},"CLOSBL6_v1_3469","conserved protein of unknown function"]
[{"$nulls":4},"CLOSBL6_v1_0694","Electron transport complex subunit RsxB"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)","CLOSBL6_v1_2699","putative Ech hydrogenase subunit A","RPTR7040359"]
[{"$nulls":4},"CLOSBL6_v1_2700","putative Ech hydrogenase subunit B"]
[{"$nulls":4},"CLOSBL6_v1_2701","putative Ech hydrogenase subunit C"]
[{"$nulls":4},"CLOSBL6_v1_2702","putative Ech hydrogenase subunit D"]
[{"$nulls":4},"CLOSBL6_v1_2703","putative Ech hydrogenase subunit E"]
[{"$nulls":4},"CLOSBL6_v1_2704","putative Ech hydrogenase subunit F"]
[{"$nulls":4},"CLOSBL6_v1_2705","putative Carbamoyltransferase, hypF"]
[{"$nulls":4},"CLOSBL6_v1_2706","putative Hydrogenase assembly protein HypC"]
[{"$nulls":4},"CLOSBL6_v1_2707","protein required for maturation of hydrogenases, hypD"]
[{"$nulls":4},"CLOSBL6_v1_2708","carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein, hypE"]
[null,null,"ATPase",null,"CLOSBL6_v1_2251","putative V-type ATP synthase subunit C"]
[{"$nulls":4},"CLOSBL6_v1_2252","V-type ATP synthase subunit I"]
[{"$nulls":4},"CLOSBL6_v1_2253","ATP synthase (subunit c, component F0)"]
[{"$nulls":4},"CLOSBL6_v1_2254","ATP synthase subunit F"]
[{"$nulls":4},"CLOSBL6_v1_2255","putative V-type ATP synthase subunit E"]
[{"$nulls":4},"CLOSBL6_v1_2256","V-type ATP synthase alpha chain"]
[{"$nulls":4},"CLOSBL6_v1_2257","V-type ATP synthase beta chain"]
[{"$nulls":4},"CLOSBL6_v1_2258","V-type ATP synthase subunit D"]
[{"$nulls":4},"CLOSBL6_v1_2259","conserved protein of unknown function (CytoplasmicMembrane)"]
["H2 formation"]
["H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+","1.12.7.2","hydrogen:ferredoxin oxidoreductase","ferredoxin hydrogenase"]
[null,null,"H2ase","Periplasmic (Fe) hydrogenase","CLOSBL6_v1_0258","putative Periplasmic (Fe) hydrogenase","RPTR7040170"]
[{"$nulls":4},"CLOSBL6_v1_0260","putative Periplasmic (Fe) hydrogenase"]
[{"$nulls":4},"CLOSBL6_v1_1906","Periplasmic (Fe) hydrogenase","RPTR7040312","RPTR7040313"]
[{"$nulls":4},"CLOSBL6_v1_2017","Periplasmic (Fe) hydrogenase","RPTR7040323"]
[]
["H(2) + NADP(+) <=> H(+) + NADPH","1.1.12.3","hydrogen:NADP+ oxidoreductase",null,"CLOSBL6_v1_2179","NAD(P)H dehydrogenase","RPTR7040331","PTR7040332","RPTR7040333"]
[]
["2 H2 + NAD+ + 2 oxidized ferredoxin = 5 H+ + NADH + 2 reduced ferredoxin","1.12.1.4","bifurcating [Fe-Fe] hydorgenase","HydABC (electron confurcation)"]
[null,null,"HydABC"]
["NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster = NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster","1.6.1.4","NADH:NADP+, ferredoxin oxidoreductase"]
["Lactate conversion to iso-butyrate"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"CLOSBL6_v1_3220","L-lactate, D-lactate, and/or glycolate dehydrogenase","RPTR7040412","RPTR7040413"]
[{"$nulls":4},"CLOSBL6_v1_2713","L-lactate dehydrogenase","RPTR7040360","RPTR7040361"]
[]
["pyruvate + CO2 + NADH <=> (S)-malate + NAD+","1.1.1.38","malate dehydrogenase",null,"CLOSBL6_v1_0232","malate dehydrogenase","RPTR7040164","RPTR7040165"]
[]
["(S)-malate <=> fumarate + H2O","4.2.1.2","fumarate hydratase","fumarase","CLOSBL6_v1_0943","putative fumarate hydratase"]
["fumarate + a quinol <=> succinate + a quinone","1.3.5.1","succinate dehydrogenase",null,"CLOSBL6_v1_1411","putative succinate dehydrogenase"]
["fumarate + NADH + H+ <=> succinate + NAD+","1.3.1.6","fumarate reductase"]
["GTP + succinate + CoA <=> GDP + phosphate + succinyl-CoA","6.2.1.4","succinyl-CoA synthetase","succinyl-CoA ligase"]
["succinyl-CoA <=> (R)-methylmalonyl-CoA","5.4.99.2","methylmalonyl-CoA mutase"]
[]
["ADP + phosphate + (S)-methylmalonyl-CoA <=> ATP + propanoyl-CoA + HCO3-","6.4.1.3","propionyl-CoA carboxylase"]
["(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA","5.1.99.1","methylmalonyl-CoA epimerase"]
["(S)-methylmalonyl-CoA + pyruvate <=> propanoyl-CoA + oxaloacetate","2.1.3.1","methylmalonyl-CoA: pyruvate carboxytransferase"]
["propanoyl-CoA + HCO3- + NADH <=> 2-methyl-3-oxopropanoate + CoA + H2O + NAD+","1.2.1.27","methylmalonate-semialdehyde dehydrogenase"]
["2-methyl-3-oxopropanoate + NADH + H+  <=> 3-hydroxy-iosbutyrate + NAD+","1.1.1.31","3-hydroxyisobutyrate dehydrogenase"]
["CoA + 3-hydroxy-iosbutyrate <=> 3-hydroxy-iosbutyryl-CoA + H2O","3.1.2.4","3-hydroxyisobutyryl-CoA hydrolase"]
["3-hydroxy-iosbutyryl-CoA <=> 3-enoyl-isobutyryl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase"]
["3-enoyl-isobutyryl-CoA + a reduced electron-transfer flavoprotein <=> iso-butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase"]
["iso-butanoyl-CoA + succinate <=> succinyl-CoA + iso-butyrate","2.8.3.-","CoA transferase"]

{"sheet":"M.elsdenii","index":9,"n_rows":53,"n_cols":7,"rows_kept":53,"merged":[[0,6,0,9]]}
["Reaction","EC number","Enzyme","Synonyms","CDS","Predicted products","Repeat regions"]
["Lactate oxidation to pyruvate"]
["L-lactate <->D-lactate","5.1.2.1","Lactate racemase",null,"AZ49_00320","lactate racemization operon protein LarA","RPTR7044259"]
[null,null,"lactate permease",null,"AZ49_00330","lactate permease"]
[{"$nulls":4},"AZ49_04210","lactate permease"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"AZ49_00515","lactate dehydrogenase"]
[{"$nulls":4},"AZ49_11470","lactate dehydrogenase"]
["Pyruvate conversion to acetyl-CoA"]
["pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+","1.2.7.1","pyruvate ferredoxin oxidoreductase","pyruvate-flavodoxin oxidoreductase","AZ49_01710","pyruvate:ferredoxin (flavodoxin) oxidoreductase"]
[null,null," ",null,"AZ49_05490","pyruvate-flavodoxin oxidoreductase"]
["pyruvate + CoA +  oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin + H+","1.2.7.-"," ",null,"AZ49_06970","pyruvate-flavodoxin oxidoreductase"]
["Other acetyl-CoA formation"]
["ATP + acetate + CoA = ADP + phosphate + acetyl-CoA","6.2.1.1","acetyl-CoA synthetase","CoA ligase"]
["ATP + acetate <=> ADP + acetyl phosphate","2.7.2.1","acetate kinase","acetate kinase","AZ49_06950","acetate kinase"]
["CoA + acetyl phosphate = acetyl-CoA + phosphate ","2.3.1.8","phosphate acetyltransferase","phosphotransacetylase","AZ49AM_0981","Phosphate acetyltransferase"]
["A primary alcohol + NAD(+) <=> an aldehyde + NADH","1.1.1.1","alcohol dehydrogenase","Alcohol dehydrogenase","AZ49_00050","alcohol dehydrogenase"]
[{"$nulls":4},"AZ49_02525","alcohol dehydrogenase"]
[null,"1.2.99.7","Aldehyde oxidoreductase",null,"AZ49_03535","putative aldehyde oxidoreductase"]
["Acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + NADH","1.2.1.10","acetaldehyde dehydrogenase"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"AZ49_05685","acetyl-CoA acetyltransferase"]
[{"$nulls":4},"AZ49_05690","acetyl-CoA acetyltransferase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"AZ49_10655","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,"AZ49_00555","enoyl-CoA hydratase"]
[null,"4.2.1.55"," ",null,"AZ49_02170","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," ",null,null,"AZ49_02760","crotonase"]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"AZ49_00650","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,"AZ49_02755","acyl-CoA dehydrogenase"]
[{"$nulls":4},"AZ49_04240","acyl-CoA dehydrogenase"]
[{"$nulls":4},"AZ49_06245","acyl-CoA dehydrogenase"]
[{"$nulls":4},"AZ49_06555","acyl-CoA dehydrogenase"]
[null,null,"electron transfer flavoprotein A,B","etf","AZ49_06560","electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"AZ49_06565","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"AZ49_07320","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"AZ49_07325","electron transfer flavoprotein subunit beta"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","AZ49_00545","Acetoacetate:butyrate CoA-transferase beta subunit"]
[{"$nulls":3},"butyryl-CoA:acetate CoA transferase","AZ49_00550","Acetoacetate:butyrate CoA-transferase alpha subunit"]
[{"$nulls":4},"AZ49_02175","CoA-transferase"]
["Butyryl-CoA conversion to butyrate"]
["acyl-CoA + H2O = CoA + a carboxylate","3.1.2.20","acyl-CoA hydrolase","acyl coenzyme A hydrolase"]
[null,"3.1.1.1","acyl-CoA thioesterase","acyl coenzyme A thioesterase"]
["butanoyl-CoA + phosphate = CoA + butanoyl phosphate","2.3.1.19","phosphate butyryltransferase"]
["ADP + butanoyl phosphate <=> ATP + butanoate","2.7.2.7","butyrate kinase"]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfB","AZ49_01090","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[{"$nulls":3},"rnfA","AZ49_01095","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfE","AZ49_01100","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfG","AZ49_01105","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfD","AZ49_01110","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfC","AZ49_01115","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"," "]

{"sheet":"CPB6","index":10,"n_rows":46,"n_cols":7,"rows_kept":46,"merged":[[0,6,0,9]]}
["Reaction","EC number","Enzyme","Synonyms","CDS","Predicted products","Repeat regions"]
["Lactate oxidation to pyruvate"]
["L-lactate <->D-lactate","5.1.2.1","Lactate racemase",null,"B6259_01775","lactate racemization operon protein LarA"]
[null,null,"lactate permease"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"B6259_01780","lactate dehydrogenase"]
[{"$nulls":4},"B6259_06775","lactate dehydrogenase"]
[{"$nulls":4},"B6259_09855","L-lactate dehydrogenase"]
["Pyruvate conversion to acetyl-CoA"]
["pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+","1.2.7.1","pyruvate ferredoxin oxidoreductase",null,"B6259_09140","pyruvate:ferredoxin (flavodoxin) oxidoreductase"]
[null,null," ","pyruvate synthase"]
["pyruvate + CoA +  oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin + H+","1.2.7.-"," ","pyruvate flavodoxin oxidoreductase"]
["Other acetyl-CoA formation"]
["ATP + acetate + CoA = ADP + phosphate + acetyl-CoA","6.2.1.1","acetyl-CoA synthetase","CoA ligase","B6259_02525","acetyl-CoA synthetase"]
["ATP + acetate <=> ADP + acetyl phosphate","2.7.2.1","acetate kinase","acetate kinase","B6259_03430","acetate kinase"]
["CoA + acetyl phosphate = acetyl-CoA + phosphate ","2.3.1.8","phosphate acetyltransferase","phosphotransacetylase","B6259_07835","Phosphate acetyltransferase"]
["A primary alcohol + NAD(+) <=> an aldehyde + NADH","1.1.1.1","alcohol dehydrogenase","Alcohol dehydrogenase","B6259_03100","NADH-dependent alcohol dehydrogenase"]
[null,"1.2.99.7","Aldehyde oxidoreductase"]
["Acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + NADH","1.2.1.10","acetaldehyde dehydrogenase"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"B6259_06370","Acetyl-CoA acetyltransferase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"B6259_06360","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,"B6259_06365","enoyl-CoA hydratase"]
[null,"4.2.1.55"," "]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,"B6259_01795","acyl-CoA dehydrogenase"]
[{"$nulls":4},"B6259_02605","acyl-CoA dehydrogenase"]
[null,null,"electron transfer flavoprotein A,B","etf","B6259_01785","electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"B6259_01790","electron transfer flavoprotein subunit alpha"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase"]
[{"$nulls":3},"butyryl-CoA:acetate CoA transferase","B6259_06350","butyryl-CoA:acetate CoA-transferase"]
["Butyryl-CoA conversion to butyrate"]
["acyl-CoA + H2O = CoA + a carboxylate","3.1.2.20","acyl-CoA hydrolase","acyl coenzyme A hydrolase"]
[null,"3.1.1.1","acyl-CoA thioesterase","acyl coenzyme A thioesterase"]
["butanoyl-CoA + phosphate = CoA + butanoyl phosphate","2.3.1.19","phosphate butyryltransferase"]
["ADP + butanoyl phosphate <=> ATP + butanoate","2.7.2.7","butyrate kinase"]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfC","B6259_06230","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[{"$nulls":3},"rnfD","B6259_06235","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfG","B6259_06240","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfE","B6259_06245","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfA","B6259_06250","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfB","B6259_06255","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]

{"sheet":"M.hexanoica","index":11,"n_rows":62,"n_cols":9,"rows_kept":62,"merged":[[0,6,0,9]]}
["Reaction","EC number","Enzyme","Synonyms","CDS","Predicted products","Repeat regions"]
["Lactate oxidation to pyruvate"]
["L-lactate <->D-lactate","5.1.2.1","Lactate racemase",null,"ACT01_13720","lactate racemization operon protein LarA"]
[null,null,"lactate permease",null,"ACT01_13730","lactate permease"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"ACT01_00410","lactate dehydrogenase"]
[{"$nulls":4},"ACT01_04310","lactate dehydrogenase"]
["Pyruvate conversion to acetyl-CoA"]
["pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+","1.2.7.1","pyruvate ferredoxin oxidoreductase","pyruvate-flavodoxin oxidoreductase","ACT01_03310","Pyruvate synthase subunit PorC","RPTR7045664"]
[null,null," ","pyruvate synthase","ACT01_03315","Pyruvate synthase subunit PorD","RPTR7045665"]
[{"$nulls":4},"ACT01_03320","Pyruvate synthase subunit PorA","RPTR7045666"]
[{"$nulls":4},"ACT01_03325","Pyruvate synthase subunit PorB","RPTR7045667"]
[{"$nulls":4},"ACT01_00445","pyruvate-flavodoxin oxidoreductase"]
[{"$nulls":4},"ACT01_00545","pyruvate-flavodoxin oxidoreductase","RPTR7045630"]
[{"$nulls":4},"ACT01_02090","pyruvate-flavodoxin oxidoreductase","RPTR7045644"]
[{"$nulls":4},"ACT01_02810","pyruvate-flavodoxin oxidoreductase","RPTR7045658"]
[{"$nulls":4},"ACT01_03520","pyruvate-flavodoxin oxidoreductase","RPTR7045668","RPTR7045669","RPTR7045670"]
[{"$nulls":4},"ACT01_06665","pyruvate-flavodoxin oxidoreductase","RPTR7045700"]
["pyruvate + CoA +  oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin + H+","1.2.7.-"," ",null,"ACT01_12570","pyruvate-flavodoxin oxidoreductase","RPTR7045778"]
["Other acetyl-CoA formation"]
["ATP + acetate + CoA = ADP + phosphate + acetyl-CoA","6.2.1.1","acetyl-CoA synthetase","CoA ligase"]
["ATP + acetate <=> ADP + acetyl phosphate","2.7.2.1","acetate kinase","acetate kinase","ACT01_05435","acetate kinase"]
["CoA + acetyl phosphate = acetyl-CoA + phosphate ","2.3.1.8","phosphate acetyltransferase","phosphotransacetylase","ACT01_13325","Phosphate acetyltransferase"]
["A primary alcohol + NAD(+) <=> an aldehyde + NADH","1.1.1.1","alcohol dehydrogenase","Alcohol dehydrogenase","ACT01_02465","alcohol dehydrogenase"]
[{"$nulls":4},"ACT01_03450","alcohol dehydrogenase"]
[{"$nulls":4},"ACT01_04805","alcohol dehydrogenase"]
[{"$nulls":4},"ACT01_05115","alcohol dehydrogenase"]
[{"$nulls":4},"ACT01_06790","alcohol dehydrogenase"]
[null,"1.2.99.7","Aldehyde oxidoreductase",null,"ACT01_11045","alcohol dehydrogenase"]
[{"$nulls":4},"ACT01_04800","acetaldehyde dehydrogenase"]
["Acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + NADH","1.2.1.10","acetaldehyde dehydrogenase",null,"ACT01_04870","acetaldehyde dehydrogenase"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"ACT01_07765","acetyl-CoA acetyltransferase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"ACT01_10835","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null,"ACT01_12410","3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,"ACT01_10830","crotonase"]
[null,"4.2.1.55"," ",null,"ACT01_02995","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"ACT01_00280","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,"ACT01_02990","acyl-CoA dehydrogenase"]
[{"$nulls":4},"ACT01_10950","acyl-CoA dehydrogenase"]
[{"$nulls":4},"ACT01_11040","acyl-CoA dehydrogenase"]
[null,null,"electron transfer flavoprotein A,B","etf","ACT01_09515","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"ACT01_09520","electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"ACT01_10940","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"ACT01_10945","electron transfer flavoprotein subunit beta"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","ACT01_02540","Acetoacetate:butyrate CoA-transferase"]
[{"$nulls":4},"ACT01_02765","Acetoacetate:butyrate CoA-transferase"]
[{"$nulls":3},"butyryl-CoA:acetate CoA transferase","ACT01_03685","Acetoacetate:butyrate CoA-transferase"]
["Butyryl-CoA conversion to butyrate"]
["acyl-CoA + H2O = CoA + a carboxylate","3.1.2.20","acyl-CoA hydrolase","acyl coenzyme A hydrolase"]
[null,"3.1.1.1","acyl-CoA thioesterase","acyl coenzyme A thioesterase"]
["butanoyl-CoA + phosphate = CoA + butanoyl phosphate","2.3.1.19","phosphate butyryltransferase"]
["ADP + butanoyl phosphate <=> ATP + butanoate","2.7.2.7","butyrate kinase"]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfC","ACT01_04510","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[{"$nulls":3},"rnfD","ACT01_04515","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfG","ACT01_04520","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfE","ACT01_04525","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfA","ACT01_04530","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfB","ACT01_04535","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]

{"sheet":"Pseudoramibacter alactolyticus","index":12,"n_rows":37,"n_cols":7,"rows_kept":37,"merged":[[0,6,0,9]]}
["Reaction","EC number","Enzyme","Synonyms","CDS","Predicted products","Repeat regions"]
["Lactate oxidation to pyruvate"]
["L-lactate <->D-lactate","5.1.2.1","Lactate racemase",null,"AEQN01_210010","lactate racemase"]
[null,null,"lactate permease",null,"AEQN01_210007","lactate permease"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"AEQN01_180010","lactate dehydrogenase"]
[{"$nulls":4},"AEQN01_340027","lactate dehydrogenase"]
["Pyruvate conversion to acetyl-CoA"]
["pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+","1.2.7.1","pyruvate ferredoxin oxidoreductase","pyruvate-flavodoxin oxidoreductase",null,"Pyruvate synthase subunit PorC"]
[null,null," ","pyruvate synthase",null,"Pyruvate synthase subunit PorD"]
[{"$nulls":5},"Pyruvate synthase subunit PorA"]
[{"$nulls":5},"Pyruvate synthase subunit PorB"]
[{"$nulls":4},"AEQN01_90013","pyruvate-flavodoxin oxidoreductase"]
["pyruvate + CoA +  oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin + H+","1.2.7.-"," ",null,"AEQN01_230157","pyruvate-flavodoxin oxidoreductase"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,null,"acetyl-CoA acetyltransferase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase","AEQN01_220122"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"AEQN01_220120","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null,"AEQN01_70057","putative 3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,null,"crotonase"]
[null,"4.2.1.55"," ",null,"AEQN01_220121","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"AEQN01_210004","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,"AEQN01_220142","acyl-CoA dehydrogenase"]
[{"$nulls":4},"AEQN01_250027","acyl-CoA dehydrogenase"]
[{"$nulls":4},"AEQN01_230141","butyryl-CoA dehydrogenase"]
[null,null,"electron transfer flavoprotein A,B","etf","AEQN01_220164","electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"AEQN01_220165","electron transfer flavoprotein subunit alpha"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","AEQN01_300005","Butyryl-CoA:acetate CoA-transferase"]
[]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfB","AEQN01_140055","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[{"$nulls":3},"rnfA","AEQN01_140056","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfE","AEQN01_140057","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfG","AEQN01_140058","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfD","AEQN01_140059","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfC","AEQN01_140060","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]

{"sheet":"Pseudoramibacter fermentans","index":13,"n_rows":39,"n_cols":7,"rows_kept":39,"merged":[[0,6,0,9]]}
["Reaction","EC number","Enzyme","Synonyms","CDS","Predicted products","Repeat regions"]
["Lactate oxidation to pyruvate"]
["L-lactate <->D-lactate","5.1.2.1","Lactate racemase",null,"PFCANDIDATE_v1_30402","lactate racemase"]
[null,null,"lactate permease",null,"PFCANDIDATE_v1_30312","lactate permease"]
[{"$nulls":4},"PFCANDIDATE_v1_30379","lactate permease"]
["(S)-lactate + NAD+ → H+ + NADH + pyruvate","1.1.1.27","lactate dehydrogenase",null,"PFCANDIDATE_v1_50133","lactate dehydrogenase"]
[{"$nulls":5},"lactate dehydrogenase"]
["Pyruvate conversion to acetyl-CoA"]
["pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+","1.2.7.1","pyruvate ferredoxin oxidoreductase","pyruvate-flavodoxin oxidoreductase",null,"Pyruvate synthase subunit PorC"]
[null,null," ","pyruvate synthase",null,"Pyruvate synthase subunit PorD"]
[{"$nulls":5},"Pyruvate synthase subunit PorA"]
[{"$nulls":5},"Pyruvate synthase subunit PorB"]
[{"$nulls":4},"PFCANDIDATE_v1_40630","pyruvate-flavodoxin oxidoreductase"]
["pyruvate + CoA +  oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin + H+","1.2.7.-"," ",null,null,"pyruvate-flavodoxin oxidoreductase"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,null,"acetyl-CoA acetyltransferase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase","PFCANDIDATE_v1_50242"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"PFCANDIDATE_v1_50240","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null,null,"3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,null,"crotonase"]
[null,"4.2.1.55"," ",null,"PFCANDIDATE_v1_50241","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"PFCANDIDATE_v1_30382","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,null,"acyl-CoA dehydrogenase"]
[{"$nulls":5},"butyryl-CoA dehydrogenase"]
[null,null,"electron transfer flavoprotein A,B","etf","PFCANDIDATE_v1_30330","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"PFCANDIDATE_v1_30331","electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"PFCANDIDATE_v1_30350","electron transfer flavoprotein subunit beta"]
[{"$nulls":4},"PFCANDIDATE_v1_30351","electron transfer flavoprotein subunit alpha"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","PFCANDIDATE_v1_50349","Butyryl-CoA:acetate CoA-transferase"]
[]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfB","PFCANDIDATE_v1_40792","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[{"$nulls":3},"rnfA","PFCANDIDATE_v1_40793","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfE","PFCANDIDATE_v1_40794","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfG","PFCANDIDATE_v1_40795","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfD","PFCANDIDATE_v1_40796","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfC","PFCANDIDATE_v1_40797","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]

{"sheet":"other strains","index":14,"n_rows":161,"n_cols":7,"rows_kept":161,"merged":[[0,6,0,9]]}
["Reaction","EC number","Enzyme","Synonyms","CDS","Predicted products","Repeat regions"]
["Clostridium kluyveri DSM 555"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"CKL_3696","acetyl-CoA acetyltransferase"]
[{"$nulls":4},"CKL_3697"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase","CKL_3698"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"CKL_0458","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null,null,"3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,null,"crotonase"]
[null,"4.2.1.55"," ",null,"CKL_0454","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"CKL_0455","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,null,"acyl-CoA dehydrogenase"]
[null,null,"electron transfer flavoprotein A,B","etf","CKL_0457","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"CKL_0456","electron transfer flavoprotein subunit beta"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","CKL_3595","Butyryl-CoA:acetate CoA-transferase"]
[]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfC","CKL_1264","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[{"$nulls":3},"rnfD","CKL_1265","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfG","CKL_1266","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfE","CKL_1267","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfA","CKL_1268","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfB","CKL_1269","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]
[]
["Caproiciproducens galactitolivorans BS-1"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"SRMQ01_80008","acetyl-CoA acetyltransferase"]
[]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"SRMQ01_80006","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null,null,"3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,null,"crotonase"]
[null,"4.2.1.55"," ",null,"SRMQ01_80007","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"SRMQ01_80005","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,null,"acyl-CoA dehydrogenase"]
[null,null,"electron transfer flavoprotein A,B","etf","SRMQ01_80002","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"SRMQ01_80003","electron transfer flavoprotein subunit beta"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","SRMQ01_50151","Butyryl-CoA:acetate CoA-transferase"]
[]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfC","SRMQ01_130043","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[{"$nulls":3},"rnfD","SRMQ01_130044","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfG","SRMQ01_130045","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfE","SRMQ01_130046","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfA","SRMQ01_130047","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfB","SRMQ01_130048","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]
[]
["Eubacterium limosum KIST612"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"E4L76_RS21760","acetyl-CoA acetyltransferase"]
[]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"E4L76_RS21770","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null,null,"3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,null,"crotonase"]
[null,"4.2.1.55"," ",null,"E4L76_RS21765","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," ",null,null,"E4L76_RS15290"]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"E4L76_RS21775","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,"E4L76_RS11060","acyl-CoA dehydrogenase"]
[{"$nulls":4},"E4L76_RS15280"]
[null,null,"electron transfer flavoprotein A,B","etf","E4L76_RS21785","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"E4L76_RS21780","electron transfer flavoprotein subunit beta"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","E4L76_RS03675","Butyryl-CoA:acetate CoA-transferase"]
[{"$nulls":4},"E4L76_RS15285"]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfC","E4L76_RS04520","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[{"$nulls":3},"rnfD","E4L76_RS04525","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfG","E4L76_RS04530","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfE","E4L76_RS04535","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfA","E4L76_RS04540","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfB","E4L76_RS04545","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]
[]
["Eubacterium pyruvativorans i6"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"FNBF01_170008","acetyl-CoA acetyltransferase"]
[{"$nulls":4},"FNBF01_280037","acetyl-CoA acetyltransferase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"FNBF01_280032","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null,"FNBF01_320094","3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,null,"crotonase"]
[null,"4.2.1.55"," ",null,"FNBF01_280031","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"FNBF01_280033","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,null,"acyl-CoA dehydrogenase"]
[]
[null,null,"electron transfer flavoprotein A,B","etf","FNBF01_280036","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"FNBF01_280035","electron transfer flavoprotein subunit beta"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","FNBF01_170007","Butyryl-CoA:acetate CoA-transferase"]
[{"$nulls":4},"FNBF01_280034"]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfB","FNBF01_260069","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[{"$nulls":3},"rnfA","FNBF01_260070","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfE","FNBF01_260071","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfG","FNBF01_260072","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfD","FNBF01_260073","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfC","FNBF01_260074","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]
[]
["Candidatus Weimeria bifida"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"WBCANDIDATE_v1_90158","acetyl-CoA acetyltransferase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"WBCANDIDATE_v1_90159","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null,"WBCANDIDATE_v1_20607","3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,null,"crotonase"]
[null,"4.2.1.55"," ",null,"WBCANDIDATE_v1_70329","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"WBCANDIDATE_v1_90160","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,null,"acyl-CoA dehydrogenase"]
[]
[null,null,"electron transfer flavoprotein A,B","etf","WBCANDIDATE_v1_90162","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"WBCANDIDATE_v1_90161","electron transfer flavoprotein subunit beta"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","WBCANDIDATE_v1_100025","Butyryl-CoA:acetate CoA-transferase"]
[]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfC","WBCANDIDATE_v1_60322","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[{"$nulls":3},"rnfD","WBCANDIDATE_v1_60323","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfG","WBCANDIDATE_v1_60324","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfE","WBCANDIDATE_v1_60325","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfA","WBCANDIDATE_v1_60326","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfB","WBCANDIDATE_v1_60327","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)","WBCANDIDATE_v1_60023","putative Ech hydrogenase subunit F"]
[{"$nulls":4},"WBCANDIDATE_v1_60024","putative Ech hydrogenase subunit E"]
[{"$nulls":4},"WBCANDIDATE_v1_60025","putative Ech hydrogenase subunit D"]
[{"$nulls":4},"WBCANDIDATE_v1_60026","putative Ech hydrogenase subunit C"]
[{"$nulls":4},"WBCANDIDATE_v1_60027","putative Ech hydrogenase subunit B"]
[{"$nulls":4},"WBCANDIDATE_v1_60028","putative Ech hydrogenase subunit A"]
[{"$nulls":4},"WBCANDIDATE_v1_60019","carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein, hypE"]
[{"$nulls":4},"WBCANDIDATE_v1_60020","protein of unknown function"]
[{"$nulls":4},"WBCANDIDATE_v1_60021","protein required for maturation of hydrogenases, hypD"]
[{"$nulls":4},"WBCANDIDATE_v1_60022","putative Hydrogenase assembly protein HypC"]
[]
["Clostridium luticellarii DSM 29923"]
["Reverse β-oxidation "]
["2 acetyl-CoA <=> acetoacetyl-CoA + coenzyme A ","2.3.1.9","acetyl-CoA acetyltransferase",null,"PVXP_v1_70076","acetyl-CoA acetyltransferase"]
[null,"2.3.1.16","3-ketoacyl-CoA thiolase","3-oxoacyl-CoA thiolase"]
["acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NADP+ ","1.1.1.157","3-hydroxybutyryl-CoA dehydrogenase",null,"PVXP_v1_10115","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"1.1.1.35","3-hydroxyacyl-CoA dehydrogenase",null,null,"3-hydroxyacyl-CoA dehydrogenase"]
["(S)-3-hydroxybutanoyl-CoA ↔ crotonyl-CoA + H2O","4.2.1.150","enoyl-CoA hydratase",null,null,"crotonase"]
[null,"4.2.1.55"," ",null,"PVXP_v1_10119","enoyl-CoA hydratase"]
["a short-chain (3S)-3-hydroxyacyl-CoA ← a short-chain trans-2,3-dehydroacyl-CoA + H2O"," "]
["crotonyl-CoA + a reduced electron-transfer flavoprotein ↔ butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+","1.3.8.1","butyryl-CoA dehydrogenase",null,"PVXP_v1_10118","acyl-CoA dehydrogenase"]
[null,"1.3.99.-","acyl-CoA dehydrogenase",null,"PVXP_v1_80062","acyl-CoA dehydrogenase"]
[]
[null,null,"electron transfer flavoprotein A,B","etf","PVXP_v1_10116","electron transfer flavoprotein subunit alpha"]
[{"$nulls":4},"PVXP_v1_10117","electron transfer flavoprotein subunit beta"]
["Butanoyl-CoA + acetoacetate <=> butanoate + acetoacetyl-CoA","2.8.3.-","CoA transferase","acyl-CoA transferase","PVXP_v1_20108","Butyryl-CoA:acetate CoA-transferase"]
[{"$nulls":4},"PVXP_v1_20109"]
["Membrance proteins involved in energy conservation"]
[null,"7.1.1.1","ferredoxin:NAD oxidoreductase","rnfB","PVXP_v1_40132","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit B"]
[{"$nulls":3},"rnfA","PVXP_v1_40133","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit A"]
[{"$nulls":3},"rnfE","PVXP_v1_40134","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit E"]
[{"$nulls":3},"rnfG","PVXP_v1_40135","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit G"]
[{"$nulls":3},"rnfD","PVXP_v1_40136","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit D"]
[{"$nulls":3},"rnfC","PVXP_v1_40137","Proton-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C"]
[null,null,"energy-conserving hydrogenase","EchABCDEF (translocation of protons)"]

{"sheet":"RBO","index":15,"n_rows":25,"n_cols":7,"rows_kept":25,"hidden":true,"merged":[[2,0,7,0],[8,0,20,0],[13,1,15,1],[21,0,24,0]]}
[{"$nulls":5},"Synonyms"]
[null,"Intermediate",null,"Enzyme","EC number","Enzyme","EC number"]
["Production of acetyl-CoA","lactate","LacT","lactate permease"]
[null,"pyruvate","LDH","lactate dehydrogenase","1.1.1.27"]
[null,"acetyl-CoA","PFOR","pyruvate flavodoxin oxidoreductase","1.2.7.-","pyruvate dehydrogenase","1.2.4.1"]
[null,"acetyl-CoA","ACS","acetyl-CoA synthetase","6.2.1.1"]
[null,"acetyl-CoA","PTA, ACK","phosphate acetyltransferase, acetate kinase","2.3.1.8, 2.7.2.1"]
[null,"acetyl-CoA","ADH, ADA","acetaldehyde dehydrogenase, alcohol dehydrogenase","1.2.1.10, 1.1.1.1"]
["reverse β-oxidation","acetoacetyl-CoA","ACAT","acetyl-CoA C-acyltransferase","2.3.1.16, 2.3.1.9","acetoacetyl-CoA thiolase"]
[null,"3-hydroxybutyryl-CoA","HAD","3-hydroxyacyl-CoA dehydrogenase","1.1.1.157, 1.1.1.35","3-hydroxybutyryl-CoA dehydrogenase"]
[null,"crotonyl-CoA","ECH","enoyl-CoA hydratase","4.2.1.55, 4.2.1.17","3-hydroxybutyryl-CoA dehydratase"]
[null,"butyryl-CoA","ACD","acyl-CoA dehydrogenase","1.3.99.2, 1.3.99.-","butyryl-CoA dehydrogenase"]
[null,"butyryl-P",null,"phosphate butyryltransferase, butyrate kinase","2.3.1.19; 2.7.2.7"]
[null,"butyrate","EtfA,EtfB","electron transfer flavoprotein A,B"]
[null,null,"TE","thioesterase","3.1.2.20"]
[null,null,"CoAT","butyryl-CoA:acetate CoA transferase","2.8.3.-"]
[null,"3-keto-hexanoyl-CoA",null,"                                                                     "]
[null,"3-hydroxyhexanoyl-CoA"]
[null,"hex-2-enoyl-CoA"]
[null,"hexanoyl-CoA"]
[null,"hexanoate"]
["ferredoxin oxidation",null,"Rnf","ferredoxin–NAD+ oxidoreductase–Na+ translocating","1.18.1.8"]
[null,null,"H2ase","ferredoxin hydrogenase","1.12.7.2"]
[null,null,"HydABC","bifurcating [Fe-Fe] hydorgenase","1.12.1.4"]
[null,null,"Ech","energy-conserving hydrogenase (EchABCDEF)"]

{"sheet":"iso-butyrate","index":16,"n_rows":18,"n_cols":15,"rows_kept":18,"hidden":true}
["Reaction","Enzyme","EC number","synonyms","Label","Begin","End","Length","Product","GC Content","GC3 Content","CAI","Mw (Da)","pI","Repeat regions"]
["L-lactate <->D-lactate","Lactate racemase","5.1.2.1",null,"CLOSTRIBL3_v1_11116",1079732,1081006,1275,null,0.3671,0.2706,0.67,46236.72,7.15]
[null,"L-lactate permease",null,null,"CLOSTRIBL3_v1_11117",1081059,1082585,1527,null,0.3975,0.2888,0.66,53204.88,9.57]
["lactate-> pyruvate","lactate dehydrogenase","1.1.1.27",null,"CLOSTRIBL3_v1_10010",8920,10164,1245,null,0.3566,0.3253,0.61,47619.64,8.75]
[{"$nulls":4},"CLOSTRIBL3_v1_10012",15292,16254,963,null,0.3915,0.3146,0.64,34973.78,6.03]
[{"$nulls":4},"CLOSTRIBL3_v1_12309",2277379,2278449,1071,null,0.3782,0.2493,0.7,37918.43,7.7]
[null,"Hydroxyacid dehydrogenase",null,null,"CLOSTRIBL3_v1_10312",331199,332152,954,"Hydroxyacid dehydrogenase",0.3616,0.3333,0.58,35019.28,8.37,"RPTR7039804"]
["pyruvate-> 2-acetolactate","acetolytate synthase"]
["2-acetolactate -> 2-3,dihydroxyisovalerate","keto-acid reductoisomerase"]
["2-3,dihydroxyisovalerate -> 2-ketoisovalerate","dehydroxy acid dehydratase"]
["2-ketoisovalerate -> iso-butyraldehyde","2-keto acid decarboxylase"]
["isobutyaldehyde -> isobutyric acid","alcohol dehydrogenase"]
[]
[]
["n-butyrate -> iso-butyrate"]
["butyrate -> butyryl-CoA "]
["butyryl-CoA -> iso-butyryl-CoA","butyryl-CoA:isobutyryl-CoA mutase","5.4.99.13","2-methylpropanoyl-CoA CoA-carbonylmutase"]
[null,"mutase acticities depend on coenzyme B12"]

{"sheet":"Acrylate pathway","index":17,"n_rows":12,"n_cols":4,"rows_kept":12,"hidden":true,"merged":[[1,0,5,0],[6,0,11,0]]}
[null,"Intermediate","Enzyme","EC number"]
["acrylate pathway","lactate"]
[null,"lactyl-CoA","lactate CoA transferase"]
[null,"acrylyl-CoA","lactyl-CoA dehydratase","4.2.1.54"]
[null,"propionyl-CoA","acrylyl-CoA reductase","1.3.1.X"]
[null,"propionate","propionyl-CoA transferase","2.8.3.1"]
["reverse β-oxidation ","propionyl-CoA","propionate transferase"]
[null,"3-ketopentanoyl-CoA","acetyl-CoA C-acyltransferase"]
[null,"3-hydroxypentanoyl-CoA","3-hydroxyacyl-CoA dehydrogenase"]
[null,"pent-2-enoyl-CoA","enoyl-CoA hydratase"]
[null,"pentanoyl-CoA","acyl-CoA dehydrogenase"]
[null,"n-valerate"]

{"sheet":"FAB","index":18,"n_rows":35,"n_cols":7,"rows_kept":35,"hidden":true,"merged":[[0,0,1,0],[0,1,1,1],[0,2,1,2],[0,3,1,3],[0,4,1,4],[0,5,1,5],[0,6,1,6],[3,0,4,0],[3,1,4,1],[6,0,9,0],[6,1,9,1],[10,0,14,0],[10,1,14,1],[17,0,20,0],[17,1,20,1],[21,0,22,0],[21,1,22,1],[23,0,26,0],[23,1,26,1],[27,0,28,0],[27,1,28,1],[29,0,30,0],[29,1,30,1],[31,0,34,0],[31,1,34,1]]}
["Abbreviation","Name","Gene","Definition","KO entry","EC no.","COG"]
[]
["Reverse β oxidation"]
["    TLA","Thiolase","fadA","Acetyl-CoA acyltransferase","K00632","2.3.1.16","COG0183"]
[null,null,"HADHB","Acetyl-CoA acyltransferase","K07509","2.3.1.16"]
["    KCR","Ketoacyl-CoA reductase","phbB","Acetoacetyl-CoA reductase","K00023","1.1.1.36","COG1028"]
["    HCD","Hydroxyacyl-CoA dehydratase","fadB","3-Hydroxybutyryl-CoA dehydrogenase","K00074","1.1.1.157","COG1250"]
[null,null,"fadJ","3-Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase","K01782","1.1.1.35, 4.2.1.17, 5.1.2.3","COG1250, COG1024"]
[null,null,"fadN","3-Hydroxyacyl-CoA dehydrogenase","K07516","1.1.1.35","COG1250, COG1024"]
[null,null,"HADH","3-Hydroxyacyl-CoA dehydrogenase","K00022","2.3.1.16"]
["    ECR","Enoyl-CoA reductase","ysiB, fadB","Enoyl-CoA hydratase","K13767","4.2.1.17","COG1024"]
[null,null,"fadJ","3-Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase","K01782","1.1.1.35, 4.2.1.17, 5.1.2.3","COG1250, COG1024"]
[null,null,"paaF, echA","Enoyl-CoA hydratase","K01692","4.2.1.17","COG1024"]
[null,null,"echA","Ech hydrogenase subunit A","K14086"]
[null,null,"crt","3-Hydroxybutyryl-CoA dehydratase","K01715","4.2.1.17"]
["    TES","Thioesterase","yciA","Acyl-CoA thioesterase YciA","K10806","3.1.2.−","COG1607"]
["Fatty acid biosynthesis"]
["    ACC","Acetyl-CoA carboxylase","accA","Acetyl-CoA carboxylase carboxyl transferase subunit alpha","K01962","6.4.1.2","COG0825"]
[null,null,"accB","Acetyl-CoA carboxylase biotin carboxyl carrier protein","K02160",null,"COG0511"]
[null,null,"accC","Acetyl-CoA carboxylase, biotin carboxylase subunit","K01961","6.4.1.2, 6.3.4.14","COG0439"]
[null,null,"accD","Acetyl-CoA carboxylase carboxyl transferase subunit beta","K01963","6.4.1.2","COG0777"]
["    MAT","Malonyltransferase","fas","Fatty acid synthase, bacteria type","K11533","2.3.1.−"]
[null,null,"fabD","[Acyl-carrier-protein] S-malonyltransferase","K00645","2.3.1.39","COG0331"]
["    KAS","Ketoacyl-ACP synthase","fas","Fatty acid synthase, bacteria type","K11533","2.3.1.−"]
[null,null,"fabB","3-Oxoacyl-[acyl carrier protein] synthase I","K00647","2.3.1.41","COG0304"]
[null,null,"fabF","3-Oxoacyl-[acyl carrier protein] synthase II","K09458","2.3.1.179","COG0304"]
[null,null,"fabH","3-Oxoacyl-[acyl carrier protein] synthase III","K00648","2.3.1.180","COG0332"]
["    KAR","Ketoacyl-ACP reductase","fas","Fatty acid synthase, bacteria type","K11533","2.3.1.−"]
[null,null,"fabG","3-Oxoacyl-[acyl carrier protein] reductase","K00059","1.1.1.100","COG1028"]
["    HAD","Hydroxyacyl-ACP dehydratase","fas","Fatty acid synthase, bacteria type","K11533","2.3.1.−"]
[null,null,"fadZ","3-Hydroxyacyl-[acyl carrier protein] dehydratase","K02372","4.2.1.59","COG0764"]
["    EAR","Enoyl-ACP reductase","fas","Fatty acid synthase, bacteria type","K11533","2.3.1.−"]
[null,null,"fabI","Enoyl-[acyl carrier protein] reductase I","K00208","1.3.1.9, 1.3.1.10","COG0623"]
[null,null,"fabK","Enoyl-[acyl carrier protein] reductase II","K02371","1.3.1.−","COG2070"]
[null,null,"fabL","Enoyl-[acyl carrier protein] reductase III","K10780","1.3.1.−","COG1028"]

{"sheet":"Sheet1","index":19,"n_rows":0,"n_cols":0,"rows_kept":0,"hidden":true}