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[{"$nulls":3},"SEARCH THEMES"]
["LG","DMC-related gene","transcriptomic study","blood","stress","immunity","hormones","brain","glucose","behavior","others","Description","References","doi or PMID identifier"]
["LG1A","FOXJ3","(W - brain)",null,"X",null,null,"X",null,"X",null,"The forkhead box J3 (FOXJ3) gene associated to three hypomethylated marks in sea bass has been shown to be implied in rheumatoid arthritis in human (Ban et al. 2013) which is a symptom associated to the stress response for a while (e.g. Selye 1951; Cutolo and Straub 2006).","Ban JY, Park HJ, Kim SK et al. 2013. Mol Med Rep. 8(4):1235-1241    /    Selye H. 1951. Am J Med. 10(5): 549‐555   /    Cutolo M, Straub RH 2006. Neuroimmunomodulation 13(5-6): 277-282. ","doi:N310.3892/mmr.2013.1623        doi:10.1016/0002-9343(51)90327-0        doi:10.1159/000104855"]
["LG3","ABLIM2","(W- brain )",null,"X",null,null,"X",null,"X",null,"ABLIM proteins are zinc-finger LIM-kinase proteins that have a role in axone guidance and path finding as largely demonstrated in C. elegans (e.g. DeMarco and Lundquist 2010), but also in human cell lines (Hassanlou et al. 2017). They acts and binds on actin to modify the cytoskeleton of neurons, but also other cell types. In neurons, one interaction with GLI proteins (see below) is recognized (Schneider et al. 2015), but literature did not recorded directly ABLIM2 and GLI2 has found in this study. As zinc finger proteins however, LIM-kinases may interact with other molecules that regulates the action of BDNF (Spencer et al. 2008; Dong et al. 2012; Koh et al. 2014). Found diffrentially expressed in guppy's brain during mate choice experiments (Bloch et al. 2018).","Demarco RS, Lundquist EA. 2010. PLoS Genet. 6(11):e1001215     /     Hassanlou M, Soltani BM, Mowla SJ. 2017. J Mol Neurosci. 63(2):254-266     /     Schneider P, Bayo-Fina JM, Singh R, et al. 2015. Nat Commun. 6: 8023    /     Spencer JL, Waters EM, Milner TA, McEwen BS. 2008. Neuroscience. 155(4): 1106-1119     /     Dong Q, Ji YS, Cai C, Chen ZY. 2012. J Biol Chem. 287(50): 41720-41731    /    Koh JY, Lim JS, Byun HR, Yoo MH. 2014. Mol Brain. 7:64    /      Bloch NI, Corral-López A, Buechel SD et al. 2018.Nat Ecol Evol. 2(11): 1772-1781 \n","doi:10.1371/journal.pgen.1001215    doi:10.1007/s12031-017-0954-5      doi:10.1038/ncomms9023      doi:10.1016/j.neuroscience.2008.05.049       doi:10.1074/jbc.M112.405415      doi:10.1186/s13041-014-0064-z     doi:10.1038/s41559-018-0682-4"]
["LG4","CELA3b",null,"X",{"$nulls":4},"X",null,null,"Loss-of-function mutations at the chymotrypsin-like elastase family member 2b and 3b (CELA2b and CELA3b) gene were found to affect plasma insulin, insulin sensitivity and platelet activation in human (Esteghamat et al. 2019).","Esteghamat F, Broughton JS, Smith E, et al. Nat Genet. 2019. 51(8): 1233-1243. ","doi:10.1038/s41588-019-0470-3"]
["LG4","NCBP2","(R - brain)           (W - brain)",null,"X",null,null,"X",null,"X","X","The protein encoded by the NCBP2 (nuclear cap binding protein 2)  gene is essential to protect cellular RNA polymerase II transcripts from degradation and to guide them through the sequence of steps leading from transcription to translation. As the cellular response to environmental challenges requires immediate and precise regulation of transcriptional programs, differences in cytosine methylation among pre- and post-stress sea bass close the NCBP2 gene could influence the stress response. This role in transcriptional modulation was recently proved by Singh et al. (2020) and NCBP2 was shown to participate to processes that act on neurodevelopmental programs in both Drosophila and Xenopus, including the synaptic transmission in close association to DLG1a (see below for other functions associated to this latter gene).","Singh MD, Jensen M, Lasser M, et al. PLoS Genet. 16(2): e1008590. ","doi:10.1371/journal.pgen.1008590"]
["LG5","CILP1","( R - brain)                        (AP - muscle)",null,"X",null,null,"X","(X)","X",null,"Apart from being reported by (R) and (W), the cartilage intermediate layer protein-1 (CILP-1) gene is known to be implied in cartilage production.  We reported the best BLAST hit in this study ,but note that the CILP-2 gene was recently shown to be involved in glucose metabolism and to respond to/to be a potential marker of  metabolism impairments (Wu et al. 2019). CILP2 was found mentioned in some studies of our literature surveys. This explain the brackets to the (X) in the 'glucose' cell of this table. This association is not mentioned in Fig. 2 of our main text.","Wu T, Zhang Q, Wu S et al. 2019. J Mol Cell Biol. 11(12): 1083-1094 ","doi:10.1093/jmcb/mjz016"]
["LG5","GRTP1a",{"$nulls":3},"X",null,"X",{"$nulls":3},"The growth hormone regulated TBC protein 1 (GRTP1) gene is regulated by the growth hormone (Lu et al. 2001), and a GWAS study indicated a relationship with body weight in the large yellow croaker, Larimichthys crocea (Wan et al. 2018). GTPR1 has also been shown to be a Th2 inducible gene (Sasaki et al. 2013) and expressed in B lymphocytes that mediate the humoral activity (Ruiz-Lafuente et al. 2018).","Lu C, Kasik J, Stephan DA et al. 2001. Endocrinology 142(10):4568-4571.  /   Wan L, Dong L, Xiao S, Han Z, Wang X, Wang Z. 2018. J Genet. 97(4): 887-895     /    Sasaki T, Onodera A, Hosokawa H, et al. 2013.PLoS ONE 8(6): e66468    / Ruiz-Lafuente N, Muro M, Minguela A et al. 2018. Biochem Biophys Rep. 16: 56-61 ","doi:10.1210/endo.142.10.8527   PMID:30262700                     doi:10.1371/journal.pone.0066468   doi:10.1016/j.bbrep.2018.09.007"]
["LG6","GDPGP1",null,null,"X","X",null,"X","X",null,null,"Gdp-d-glucose phosphorylase 1-like (GDPGP1) is a stress-related metabolic enzyme that affects glycogen metabolism in neurons in the nematode Caenorhabditis elegans and promotes neuron survival (Singhal et al. 2020; Schulz et al. 2020). Translation of its activity in quality control of nucleoside diphosphate sugar glycosylation to mammals and other vertebrates have been supposed for years (Adler et al. 2011).","Singhal NS, Lee EM, Ma DK. 2020. J Cell Biol. 219(2): e202001006     /     Schulz A, Sekine Y, Oyeyemi MJ, et al. 2020. J Cell Biol. 219(2): e201807127      /      Adler LN, Gomez TA, Clarke SG, Linster CL. 2011. J Biol Chem. 286(24): 21511-21523. ","doi:10.1083/jcb.202001006         doi:10.1083/jcb.201807127      doi:10.1074/jbc.M111.238774"]
["LG6","GLG1","(W - brain)        (GP - brain)",null,"X",null,"X","X",null,"X",null,"In the brain, the Golgi apparatus protein 1-like (GLG1) gene was shown to be activated by the norephinephrin pathway and to participate to the regulation of gonadotropin in the porcine pituitary (Li et al. 2020). Its expression is related to the expression of PTGFRN, also found in this study (Ahmed et al. 2017). Stress responsiveness studies, but we may also postulate normal regulation of GLG1a without stress with implication in sexual determination.","Li X, Li H, Zhang D et al. 2020. J Endocrinol. 244(3): 459-471    /    Ahmed K, LaPierre MP, Gasser E, et al. 2017. J Clin Invest. 127(3):1061-1074. ","doi:10.1530/JOE-19-0331              doi:10.1172/JCI90031"]
["LG6","KBTBD13 ",null,"X",null,"X",{"$nulls":5},"The Kelch repeat and BTB domain-containing protein 13-like (KBTBD13) gene that encompasses three hypomethylated DMCs in sea bass and – while very poorly studied – is first considered as involved in muscle contractility (de Winter et al. 2020), but also in the innate immunity system and implied in motor neuropathy in humans (Previtali et al. 2019). Such neuropathies are associated to several metabolisms, including changes in blood vascular homeostasis and blood haemodynamics (e.g. Pi et al. 2018).","de Winter JM, Molenaar JP, Yuen M, et al. 2020. J Clin Invest. 130(2):754-767    /    Previtali SC, Zhao E, Lazarevic D, et al. 2019. J Neurol Neurosurg Psychiatry 90(10):1171-1179    /    Pi X, Xie L, Patterson C. 2018. Circ Res. 123(4): 477-494. ","doi:10.1172/JCI124000        doi:10.1136/jnnp-2019-320717  doi:10.1161/CIRCRESAHA.118.313237 "]
["LG8","BTPF",{"$nulls":5},"X",null,null,"X","The BTPF gene is a nucleosome remodelling factor. Nucleosome remodelling factors participate to a regulated and competitive interplay between chromatin-binding factors and nucleosomes that promote the establishment of features that dynamically control gene expression in response to environmental or developmental clues (Klemm et al. 2019). Nucleosome remodelling may control cytosine methylation, including the epigenetic response to stress (e.g. Sun et al. 2015) and synaptic reshaping and memory (Campbell and Wood 2019).","Klemm S., Shipony Z, Greenleaf WJ. 2019. Nat Rev Genet. 20(4): 207–220   /    Campbell RR, Wood MA. 2019. Nat Rev Neurosci. 20(3): 133-147   /    Sun H, Damez-Werno DM, Scobie KN et al. 2015. Nat Med. 21(10): 1146–1153.   ","doi:10.1038/s41576-018-0089-8   doi:10.1038/s41583-019-0121-9   doi:10.1038/nm.3939"]
["LG10","ADCY1b","(W - brain)        (GP - brain)","X","X",null,"X","X",null,"X",null,"This complements the main text: ADCY1 promotes the macrophage function (i.e. the non specific immune function) in snakeheads (Channa spp.) (Roy and Rai 2008). It has been reported in mammals that AC was also implied in the differentiation of erythroid cells with prostaglandins E1 and E2 consistently enhancing AC activity of erythroblasts on different stages of development (Setchenska 1990). It should be further noticed that prostaglandins E2 whom a hypermethylated negative activator was found in this study (CRTC2) is implied in T helper 1 (Th1) cell differentiation to mediate the inhibition of immune inflammation (Yao et al. 2013). AC participates to the regulation of acid-base balance and alleviate the role of catecholamine in blood (Perry and Reid 1993). Changes in brain adenyl(-ate, -yl) cyclase concentration during behavioural stress experiments are numerous (Morrill et al. 1993, Wolfgang et al. 1994; Klenerová et al. 1999; Kim  and Han 2009). AC is associated to BDNF expression, but also to corticotroping-releasing hormone in hypothalamus (Pihoker et al. 1992). Stress responsiveness of ADCY1 induced by epinephrin is demonstrated (Bennun 2010).","Roy B, Rai U. 2008. Gen Comp Endocrinol. 155(2): 298-306    /    Setchenska MS. 1990. Acta Physiol Pharmacol Bulg. 16(2): 3-10    /    Yao C, Hirata T, Soontrapa K et. al. 2013. Nat Commun. 4:1685    /    Perry SF, Reid SD 1993. Fish Physiol Biochem. 11: 195-203    /      Morrill AC, Wolfgang D, Levine MA et al. 1993. Life Sci. 53(23): 1719-1727    /    Wolfgang D, Chen I, Wand GS.1994. Neuropsychopharmacology 11(3):187-193    /     Kim KS, Han PL. 2009 J Neurosci Res. 87(13): 2983-93   /   Klenerová V, Sída P, Englisová D et al. 1999. Physiol Res. 48(6): 513-517    /   Pihoker C, Cain ST, Nemeroff CB. 1992. Prog Neuropsychopharmacol Biol Psychiatry. 16(4): 581-586     /    Bennun A. 2010. Biosystems 100(2): 87-93. ","doi:10.1016/j.ygcen.2007.05.008      PMID:2281799     doi:10.1038/ncomms2684    doi:10.1007/BF00004567    doi:10.1016/0024-3205(93)90158-y  doi:10.1038/sj.npp.1380105   PMID:10783918   doi:10.1002/jnr.22119     doi:10.1016/0278-5846(92)90063-k     doi:10.1016/j.biosystems.2010.02.001"]
["LG10","PBX1b","(W - brain)     (V  -  brain)","X","X",null,"X","X",null,"X",null,"The pre-B-cell leukemia homeobox 1 (PBX1) gene is a transcription factor originally found as involved in lymphoblastic leukemia (Kamps et al. 1990). PBX1 was found differentially expressed in the brain of guppy during mate choice experiments (Bloch et al. 2018), and its expression in the brain was associated to locomotor and behavioral alterations in zebrafish (Gerlai et al. 2017). Its role in hematopoeisis has been demonstrated (Cvejic et al. 2011; Dassé et al. 2012), as well as its involvement in the development of the adrenal cortex and steroidogenesis (cortisol, Kagawa et al. 1994; Hammer et al. 2005; Lichtenauer et al. 2007). It was shown to be involved  in the development of dopaminergic neurons when impaired by diseases (Villasescusa et al. 2016).","Kamps MP, Murre C, Sun, X et al. 1990. Cell 60: 547-555    /    Bloch NI, Corral-López A, Buechel SD et al. 2018. Nat Ecol Evol. 2(11): 1772-1781     /     Gerlai R, Poshusta TL, Rampersad M et al. 2017. Behav Genet. 47(1): 125-139     /     Cvejic A, Serbanovic-Canic J, Stemple DL et al. 2011. Haematologica. 96(2): 190-198     /     Dassé E, Volpe G, Walton DS, et al. 2012. Blood Cancer J. 2(6):e76    /     Kagawa N, Ogo A, Takahashi Y, et al. 1994. J Biol Chem. 269(29):18716-18719   /   Hammer GD, Parker KL, Schimmer BP. 2005. Endocrinology. 146(3):1018-1024    /     Lichtenauer UD, Duchniewicz M, Kolanczyk M et al. 2007. Endocrinology. 148(2): 693-704     /    Villaescusa JC, Li B, Toledo EM, et al. 2016. EMBO J. 35(18): 1963-1978.  ","doi:10.1016/0092-8674(90)90658-2    doi:10.1038/s41559-018-0682-4      doi:10.1007/s10519-016-9818-y     doi:10.3324/haematol.2010.027698   doi:10.1038/bcj.2012.20                       PMID:7913464                doi:10.1210/en.2004-1385      doi:10.1210/en.2006-0681        doi:10.15252/embj.201593725"]
["LG11","MMRN2a",null,"X",{"$nulls":3},"X",null,"X",null,"Multimerin-2 (MMRN2) is involved in vascular homeostasis (Pellicani et al. 2020), but also specific pathways of astrocyte development in brain whom impairment lead to cognitive disorders (Liang et al. 2020).","Pellicani R, Poletto E, Andreuzzi E et al. 2020. Matrix Biol. 87:11-25     /     Liang Q, Su L, Zhang D et al. 2020. Proc Natl Acad Sci USA 117(17): 9413-9422. ","doi:10.1016/j.matbio.2019.08.002    doi:10.1073/pnas.1922713117"]
["LG12","FBXO33","(V  - brain)",null,null,"(X)",null,"X",null,"X",null,"In GWAS, a second intergenic DMC related to the FBXO33 (F-box protein 33) gene has been found significantly related to activity levels and reactivity in mice (Sanchez-Mora et al. 2015), but also infighting contest in the Siamese fighting fish Betta splendens( ref. in captions of the this table). More generally, FBXO proteins are known to be involved in response to pathogens and immunity (Correa et al. 2013, in brackets as not specific to FBXO33 and not reported in Fig. 2).","Sánchez-Mora C, Ramos-Quiroga JA, Bosch R, et al. 2015. Neuropsychopharmacology 40(4): 915-926     /    Correa RL, Bruckner FP, de Souza Cascardo R et al. 2013. Int J Mol Sci. 14(2): 4030–4049.","doi:10.1038/npp.2014.267    doi:10.3390/ijms14024030"]
["LG12","SASH1A","(W - brain)        (GP - brain)",null,"X","X",null,"X",null,"X"]
["LG14","CLDN4","(B - brain)    (Wa - brain)","X",null,"X",{"$nulls":3},"X","X","The claudin 4 (CLDN4) gene is known to participate to the regulation of blood pressure and acid-base homeostasis in kidney (Leiz and Schmidt-Ott 2019). The action of claudins in erythropoeisis has been reported in mammals (Thompson et al. 2010). It has been proposed that CLDN4 could also have a role in neuropathies leading to glucose metabolism impairments (diabetes; Gastoł et al. 2020).","Leiz J, Schmidt-Ott KM. 2019. Int J Mol Sci. 21(1):221    /    Thompson PD, Tipney H, Brass A et al. 2010. PLoS One 5(9): e12667    /     Gastoł J, Kapusta P, Polus A et al. 2020. Endocrine 68: 235-240. ","doi:10.3390/ijms21010221                   doi:10.1371/journal.pone.0012667       doi:10.1007/s12020-019-02172-9"]
["LG14","COL4A5*","(W - brain)       (GP - brain)",null,"X",null,null,"X",null,"X"]
["LG14","ROBO3","(W - brain)       (GP - brain)",null,"X","X",null,"X",null,"X",null,"Zhang W. et al. (2018) showed one association of BTR30/TRIM39 (below) with the activity of the ROBO3 (also known as RIG1) gene which is involved in immunity (e.g. Loo and Gale 2011), notably against fish pathogens (e.g. Yong et al. 2017), but also indirectly in glycolysis and lactate metabolism when the immune response following stress is activated (Zhang W. et al. 2019). In zebrafish, Burgess et al. (2009) suggested an association between ROBO3 and the startle response during chronic stress challenge, and Yergeau et al. (2005) showed a relationship with erythropoiesis (blood volume). Note that out String search (main text) reported associations with PRKCQ (LG UN) and LRRC3 (LG 24), each also involved in the immune response. However our literature survey did not find clear references and support on such associations.","Zhang W, Jia P, Liu W et al. 2018. Fish Shellfish Immunol. 75:1-7     /      Loo YM, Gale M. Jr. 2011. Immunity 34(5): 680-692    /    Yong CY, Yeap SK, Omar AR et al. 2017.PeerJ 5: e3841    /     Zhang W, Wang G, Xu ZG et al. 2019. Cell. 178(1):176-189.e15    / Burgess HA, Johnson SL, Granato M. 2009. Genes Brain Behav. 8(5):500-511   /    Yergeau DA, Cornell CN, Parker SK et al. 2005. Dev Biol. 283(1): 97-112. ","doi:10.1016/j.fsi.2018.01.039             doi:10.1016/j.immuni.2011.05.003   .                     doi:10.7717/peerj.3841                          doi:10.1016/j.cell.2019.05.003    doi:10.1111/j.1601-183X.2009.00499.x   doi:10.1016/j.ydbio.2005.04.006"]
["LG14","TMEM132E",null,"X",{"$nulls":5},"X",null,"TMEM132E (transmembrane protein 132E) is associated to panic disorder susceptibility in human (Gregersen et al. 2014), then to sensibility to acute stress. One association with LRRTM4L2 on LG20 is known (see below).","Gregersen NO, Buttenschøn HN, Hedemand A et al. 2004. Psychiatr Genet. 24(1): 37-41. ","doi:10.1097/YPG.0000000000000022"]
["LG16","CSMD3a","(W - brain)            (T  - brain)          (V  -  brain)",null,"X",null,null,"X",null,"X",null,"The CUB and Sushi multiple domains 3 (CSMD3) gene is related to psychiatric disorders in human with orthologs in zebarfish (Thyme et al. 2019). It is expressed in hippocampal neuron and act as a co-receptor of various proteins and implied in dendritic development (Mizukami et al. 2016). Its is however found in other epigenomic studies that did not regard blood or brain.","Thyme SB, Pieper LM, Li EH et al. 2019. Cell. 177(2):478‐491.e20    /     Mizukami T, Kohno T, Hattori M. 2016. Neurosci Res. 110: 11-17. ","doi:10.1016/j.cell.2019.01.048     doi:10.1016/j.neures.2016.03.003"]
["LG16","FURIN","(R - brain)            (W - brain)","X","X","X","X","X","X","X",null,"This complements the main text: Apart from issue on mature of BDNF developed in the main text, furin cleavable activity (FURIN gene) is involved in glucose metabolism (control of glucose plasma level; e.g. Han et al. 2012; Fernandez et al. 2018), and in the metabolism of glycogen in brain astrocytes (Chen et al. 2015). It may modulate neurodegeneration due to impairments of some genes of the  leucine-rich repeat family (Maksoud et al. 2019) (some found in this study: LRRC3, LRRMT4L2). It cleaves numerous toxins and pathogens (non specific immunity; e.g. Ojanen et al. 2015, Zhao et al. 2018). It is implied in angiogenesis (Toledano et al. 2016; Vähätupa et al. 2018), associated to blood pressure regulation (International Consortium for Blood Pressure Genome-Wide Association Studies 2011; Turpeinen et al. 2015), hypotension after exercise (= organismal stress, Cilhoroz et al. 2019) and in bone regeneration (zebrafish; Khatib et al. 2010). Additonal insights on immunity: Ortutay et al. (2015), Li et al. (2018).","Han J, Kim EH, Choi W et al. 2012. World J Gastroenterol. 18: 6420-25   /   Fernandez C, Rysä J, Almgren P et al. 2018. J Intern Med. 284: 377-387   /   Chen Y, Zhang J, Deng M. 2015. J Neurosci Res. 93:189-194   /   Maksoud E, Liao EH, Haghighi AP. 2019. Cell Rep. 26(7): 1774-1786.e4    /    Ojanen MJ, Turpeinen H, Cordova ZM et al. 2015. Infect Immun. 83:1431-42   /   Zhao G, Yang W, Wu J et al. 2018. Arterioscler Thromb Vasc Biol. 38:1837-1844    /   Toledano S, Lu H, Palacio A et al. 2016. PLoS ONE 11(12): e0168122  /  Vähätupa M, Cordova ZM, Barker H et al. 2018. Exp Eye Res. 166:160-167    /   Intern. Cons. Blood Pressure Genome-Wide Association Studies et al. 2011. Nature. 478: 103-109  /   Turpeinen H, Seppälä I, Lyytikäinen LPet al. 2015. Hum Genet. 134:627-636  /   Cilhoroz BT, Schifano ED, Panza GA et al. 2019. Physiol Rep. 7: e13952  /   Khatib AM, Lahlil R, Scamuffa N et al. 2010. PLoS One. 5(7):e11438  /  Ortutay Z, Oksanen A, Aittomäki S et al. 2015. J Leukoc Biol. 98:73-83    /    Li Y, Liu W, Guan X et al. 2018. J Immunol. 201: 2612-23. ","doi:10.3748/wjg.v18.i44.6420    doi:10.1111/joim.12783    doi:10.1002/jnr.23455      doi:10.1016/j.celrep.2019.01.07     doi:10.1128/IAI.03135-14    doi:10.1161/ATVBAHA.118.311030    doi:10.1371/journal.pone.0168122    doi:10.1016/j.exer.2017.10.013     doi:10.1038/nature10405    doi:10.1007/s00439-015-1546-5    doi:10.14814/phy2.13952     doi:10.1371/journal.pone.0011438     doi:10.1189/jlb.2A0514-257RR    doi:10.4049/jimmunol.1700808"]
["LG16","SPIRE1b","(W - brain )",null,"X",null,null,"X",null,"X",null,"The Spir proteins are encoded by two genes (SPIRE1 [homolog] and SPIRE2) and nucleate actin filaments at vesicle membranes and facilitate intracellular transport processes. In mice, it has been found that SPIRE1 knockout males – but not females – have an altered fear learning phenotype compared to their littermates, and have a deficient memory of past fear events (Pleiser et al. 2014).","Pleiser S, Banchaabouchi MA, Samol-Wolf A et al. 2014. Eur J Cell Biol. 93(5-6): 225-237","doi:10.1016/j.ejcb.2013.11.001"]
["LG16","TRMT11","(W - brain )",null,"X",null,null,"X",null,"X"]
["LG17","PLG",null,"X","X",null,"X","X",null,"X",null,"This complements the main text: PLG (plasminogen) has been shown to regulate the hematopoietic stress response (i.e. the production and differentiation of blood cells; Heissig et al. 2007). PLG might modulate the immune system during stress challenges (Baker et al. 2019). Loss of neuromotor performances are impaired in knock-out mice (Hoover-Ploh et al. 1999).","Heissig B, Lund LR, Akiyama H et al. 2007. Cell Stem Cell. 1(6): 658-670.      /      Baker SK, Chen ZL, Norris EH, Strickland S. 2019. J. Neuroinflammation. 16(1): 172     /       Hoover-Plow J, Wang N, Ploplis V 1999. Growth Dev Aging. 63(1-2):13-32. ","doi:10.1016/j.stem.2007.10.012      doi:10.1186/s12974-019-1560-y     PMID:10885855"]
["LG17","SLC22A2","(W - brain )",null,"X","X","X","X","X","X",null,"This complements the main text: Numerous studies on diabetes and others showed that the solute carrier family 22 member 2-like (SLC22A2; also known as OCT2) may participate to regulate the glucose metabolism (Maruthur et al. 2014) and control glycemia (e.g. Al-Eitan et al. 2019). Mechanisms are far to be precisely known and influence on blood lactate concentration suggests that gluconeogenesis might be specifically affected (Li et al. 2010). SLC22A2/OCT2 has been shown to bind immunoglobulin gene promoters and to participate to their expression (Shim et al. 2017), but also to bind to (nor)epinephrine to play a role in catecholamine homeostasis both in the kidney and some brain areas (Gründemann et al. 1999). ","Maruthur NM, Gribble MO, Bennett WL et al. 2014. Diabetes Care 37(3): 876-886    /      Al-Eitan LN, Almomani BA, Nassar AM et al. 2019. J Pers Med. 9(1): 17    /     Li Q, Liu F, Zheng TS et al. 2010. Acta Pharmacol Sin. 31(2):184-190    /     Shim JM, Lee JS, Russell KE et al.  2017. Epigenomics. 9(4): 393-406      /    Gründemann D, Liebich G, Kiefer N et al. 1999. Mol Pharmacol 56:1–10\n","doi:10.2337/dc13-1276         doi:10.3390/jpm9010017      doi:10.1038/aps.2009.189      doi:10.2217/epi-2016-0147     doi:10.1124/mol.56.1.1"]
["LG17","RRM2","(R - brain)          (W -brain)              (AP - liver)",null,"X",null,null,"X",null,"X",null,"See main text - Section 3.5"," - "," - "]
["LG20","BMP3","(W - brain )",null,"X",null,null,"X",null,"X"]
["LG20","FICD","(W - brain )",null,"X",null,null,"X",null,"X"]
["LG20","SART3","(W - brain )","X","X","X",null,"X",null,"X",null,"The squamous cell carcinoma antigen recognized by T-cells 3 (SART3; also known as Tip110) gene is participating to the regulation of hematopoiesis (Liu et al. 2011; Liu and He 2016) and to the immune response by inducing cytotoxic T lymphocytes (Kaji et al. 2017).","Liu Y, Timani K, Mantel C et al. 2011. Blood 117(21): 5643-51      /     Liu Y, He JJ. 2016. Curr Opin Hematol. 23(4): 325-30    /     Kaji K, Mizukoshi E, Yamashita T et al. 2017. PLoS ONE 12(1): e0170291 ","doi:10.1182/blood-2010-12-325332     doi:10.1097/MOH.0000000000000246  doi:10.1371/journal.pone.0170291"]
["LG20","LRRTM4L2",null,"X",{"$nulls":3},"X",null,"X",null,"As other members of the LRRTM family, the leucine-rich repeat transmembrane neuronal protein 4 (LRRTM4L2) is known to be expressed in the brain and promote synapse development and plasticity (e.g. Linhoff et al. 2009; Roppongi et al. 2017). Association of LRRTM4L with bipolar disorders and behaviour is reported (Bhouri et al. 2018; Reichmann et al. 2020) as other members in this family (e.g.  Söllner and Wright 2009). In human, Chen et al. (2019) showed that SNP polymorphisms were significantly associated to hypotensive patients with cognitive impairments, and that additional polymorphisms at the transmembrane TMEM132E gene (LG14) improved the association between blood flow and cognition. ","Linhoff MW, Laurén J, Cassidy RM, et al. 2009. Neuron 61(5): 734-749      /      Roppongi RT, Karimi B, Siddiqui TJ. 2017. Neurosci Res. 116:18-28   /    Bhouri M, Morishita W, Temkin P, et al. 2018. Proc Natl Acad Sci USA 115(23): E5382‐E5389       /       Reichman RD, Gaynor SC, Monson ET et al. 2020. Am J Med Genet B Neuropsychiatr Genet. 183(2):128-139   /  Söllner C, Wright GJ. 2009. Genome Biol. 10(9): R99     /    Chen YC, Liu YL, Tsai SJ et al. 2019. J Clin Med. 8(8):1124","doi:10.1016/j.neuron.2009.01.017   doi:10.1016/j.neures.2016.10.003   doi:10.1002/ajmg.b.32767      doi:10.1186/gb-2009-10-9-r99    doi:10.3390/jcm8081124       doi:10.1016/j.margen.2016.03.007"]
["LG20","TNKSb","(W - brain )       (GP - brain)","X","X",null,"X","X","X","X",null,"The tankyrase b (TNKSb) gene modulates the sensitivity of insulin, notably in skeletal muscle by regulating and participating to the translocation of the GLUT4 transporter from the nucleus through the plasma membrane (Chi and Lodish 2000; Guo et al. 2012; Su et al. 2018). This regulation GLUT4 is especially important as GLUT4 is involved in brain metabolism and participate to memory (McNay and Pearson-Leary 2020). It was also shown to upregulate adinopectin (Yeh et al. 2009). Adinopectin is one plasmatic adipocytokine associated to stress modulation (Liu et al. 2012) and a significant relationship between adinopectin level and expression of NPAS3 mentioned above have been established in human white blood cells (Zhang et al. 2013). Putatively, TNKSb can improve stress tolerance by participating to other signaling pathways (Li et al. 2018). Furthermore, in a GWAS study, TNKSb was shown to modulate the phenotypes of blood cells in sickle cell anemia (Sebastiani et al. 2010). TNKS was found located in a genomic region that probably undergone a selective sweep in sea bass (Bertolini et al. 2016) and its expression was shown to rapidly evolve in guppy (Poecilia reticulata) (Ghalambor et al. 2015).","Chi NW, Lodish HF. 2000. J Biol Chem. 275(49): 38437-38444    /     Guo HL, Zhang C, Liu Q et al. 2012. Cell Res. 22(8): 1246-57.     /     McNay EC, Pearson-Leary J. 2020. Exp Neurol. 323:113076     /      Su Z, Deshpande V, James DE et al. 218.  J Biol Chem. 293(22): 8578-8587      /       Yeh TY, Beiswenger KK, Li P, Bolin KEet al. 2009. Diabetes. 58(11): 2476-85        /       Liu J, Guo M, Zhang D et al. 2012. Proc Natl Acad Sci USA 109(30):2248-12253.      /     Zhang Y, Kent JW Jr, Olivier M, et al. 2013. BMC Med Genomics 6:14      /     Li P, Huang P, Li Xet al. 2018. Cell Rep. 25(2):437-448. .     /     Sebastiani P, Solovieff N, Hartley SW et al. 2010. Am J Hematol. 85(1): 29-35    /     Bertolini F, Geraci C, Schiavo G, Sardina MT, Chiofalo V, Fontanesi L. 2016. Mar Genomics. 28: 63-70        /      Ghalambor C.K., Hoke K.L., Ruell E.W. et al. 2015. Nature 525(7569): 372-375","doi:10.1074/jbc.M007635200             doi:10.1038/cr.2012.52                    doi:10.1016/j.expneurol.2019.113076         doi:10.1074/jbc.RA117.001058                         doi:10.2337/db08-1781                 doi:10.1073/pnas.1202835109     doi:10.1186/1755-8794-6-14                                  doi:10.1016/j.celrep.2018.09.036                             doi: 10.1002/ajh.21572    doi:10.1016/j.margen.2016.03.007       doi:10.1038/nature15256"]
["LG20","ZMAT4b","(W - brain )",null,"X",null,null,"X",null,"X"]
["LG22-25","NOL4B","(GP - brain) ","X",{"$nulls":3},"X",null,"X",null,"In zebrafish, the NOL4B (Nucleolar Protein 4b-like) gene was shown to be expressed in hematopoietic cells (Borah et al. 2016), but it was further identified in honey bee mushroom bodies that have a role in memory and was shown to have such a possible role in mice by participating to a pathway of interactions altering/modulating social behaviours when facing stressors (Takayanagi-Kiya et al. 2014, 2017). Social stress in zebrafish is associated to diffrential regulation of its expression in zebrafish brain (Goodman and Peichel 2015; ref. on first sheet of this file).","Borah S, Barrodia P, Swain RK. 2006. Int J Dev Biol. 60(1-3) :53-56    /     Takayanagi-Kiya S, Misawa-Hojo K, Kiya Tet al. 2014. Zoolog Sci. 31(11): 735-740     /    Takayanagi-Kiya S, Kiya T, Kunieda T, et al. 2017 Int J Mol Sci. 18(2): 246","doi:10.1387/ijdb.150307rs                      doi:10.2108/zs140049                doi:10.3390/ijms18020246"]
["LG22-25","CCDC30","(W - brain )",null,"X",null,null,"X",null,"X"]
["LG24","CHN1","(W - brain )","X","X","X",null,"X","X","X",null,"A role of chimerin/chaemerin (CHN1) - a proinflammatory adipokine also known as RARRES2 - in the regulation of blood pressure has been reported and its concentration in blood plasma was found correlated to several indicators of the metabolic syndrome, including circulating glucose levels (e.g. Wang et al. 2013; Suzuki et al. 2016), but this largely extends further (Ferland et al. 2020). Other studies stressed its role in the innate immune response, by increasing T cell cytotoxicity (Caloca et al. 2008; Rennier et al. 2020), but also in mechanisms of adaptive immunity to reduce inflammation (Qu and Chaikof 2010). The multifaceted roles of chimerin remains underappreciated (Helfer and Wu 2018), notably in brain health in which evidence for association with neuropathies accumulate (Lee et al. 2019), but also in the control of energy balance associated to hypothalamus remodelling (Helfer et al. 2016).","Wang D, Yuan GY, Wang XZ et al. Genet Mol Res. 12(4):5986-5991       /     Suzuki Y, Haga S, Nakano M et al. 2016. J Anim Sci. 94(11): 4600-4610     /     Ferland DJ, Mullick AE, Watts SW.  2020. Am J Hypertens. 2020:hpaa084.     /       Caloca MJ, Delgado P, Alarcón B et al. 2008. Cell Signal 20(4): 758-770      /     Rennier K, Krug E, Virdi G et al. 2020. BioRxiv     /      Qu Z, Chaikof EL. 2010. Curr Opin Immunol. 22(5): 634-642    /     Helfer G, Wu QF. 2018. J Endocrinol.  238(2): R79-R94    /     Lee TH, Cheng KK, Hoo RL et al.. 2019. Int J Mol Sci. 20(22): 5638    /     Helfer G, Ross AW, Thomson LM, et al. 2016. Sci Rep. 6: 26830","doi:10.4238/2013.November.26.8      doi:10.2527/jas.2016-0677     doi:10.1093/ajh/hpaa084             doi:10.1016/j.cellsig.2007.12.015         doi:10.1101/787697      doi:10.1016/j.coi.2010.08.017       doi:10.1530/JOE-18-0174              doi:10.3390/ijms20225638     doi:10.1038/srep26830"]
["LG24","GLI2b","(R - brain)           (W - brain)          (CP - infected cells)",null,"X","X","X","X",null,"X",null,"Mutations at the tanscription factor  GLI2 (the signalling activator of the SHH pathway) have been shown to induce hypopituitarism and to correlate with numerous complete or partial hormonal deficiencies including GH, ACTH and TSH (Cohen 2012, Arnhold et al. 2015). In zebrafish, it has been shown to regulate the numbers of hypothalamic cells releasing the gonadotropin releasing hormone (GnRH) (Whitlock et al. 2003). GLI2 exerts a role on forebrain patterning, including hypothalamus and the pituitary (Karlstrom et al. 1999). A link exists between GLI2 transcription and PACAP - one important hormone  regulating ACTH - which is itself dependent on the activity of ADCY1 gene found in this study (Juhasz et al. 2015). However if impairments of some synthesis have been reported, they apparently do not directly deals with a response to stress. GLI2 has been shown diffrentially expressed in sea bass cultured cells challenged with viruses and implied in the immune response (Chavez-Pozo et al. 2019, ref. in MS).","Cohen LE. 2012. Pediatr Endocrinol Rev. 9(4): 706-709    /    Arnhold IJ, França MM, Carvalho LR et al. 2015. J Mol Endocrinol. 54(3): R141-R150    /     Whitlock KE, Wolf CD, Boyce ML. et al. 2003. Dev Biol. 257(1):140-152    /      Karlstrom RO, Talbot WS, Schier AF. 1999. Genes Dev. 13(4): 388-393     /     Juhász T, Szentléleky E, Somogyi CS et al. 2015. Int J Mol Sci. 16(8): 17344-17367  ","PMID:23304807                                              doi:10.1530/JME-15-0009                  doi:10.1016/s0012-1606(03)00039-3    doi:10.1101/gad.13.4.388                    doi:10.3390/ijms160817344"]
["LG24","LRRC3",null,null,"(X)",{"$nulls":6},"The leucine-rich repeat containing c 3 (LRRC3) gene should be implicated in the immune response as numerous leucine-riche repeat genes, however this gene is among the less known within this family (see Söllner and Wright 2009). ","Söllner C, Wright GJ. 2009. Genome Biol. 10(9): R99","doi:10.1186/gb-2009-10-9-r99  "]
["LG24","PTGFRN ","(W - brain)                             (GP - brain)        (AP - muscle)    ",null,null,"X",null,"X",null,"X"]
["LG24","UNC80","(W - brain )          (GP - brain)",null,"X",null,"X","X",null,"X",null,"The UNC80 (Protein unc-80 homolog isoform 2) gene encodes for a protein in a complex associated to one ionic neuronal channel (NALCN) that mediates the effect of peptide neurotransmitters such like epinephrine (Lu et al. 2009). Impairments of UNC80 or other proteins that allow for proper functioning of ionic regulation showed alterations of locomotor behaviours and may represent susceptibility loci for mood disorders (Cochet-Bissuel et al. 2014). Implications of UNC80 in the modulation of behaviours in response to stressors has also been shown in Caenorhabditis elegans (Zhou et al. 2020).","Lu B, Su Y, Das S, et al. 2009. Nature 457(7230): 741-744     /     Cochet-Bissuel M, Lory P, Monteil A. 2014. Front Cell Neurosci. 8: 132     /     Zhou C, Luo J, He X, et al. 2020. G3 (Bethesda) 10(1):199-210 ","doi:10.1038/nature07579         doi:10.3389/fncel.2014.00132       doi:10.1534/g3.119.400692"]
["LGx","CELF2","(R - brain)                  (W - brain)        (V  -  brain)",null,"X","X","X","X",null,"X",null,"This complements the main text, sub-section 3.5: The CELF2 (cugbp elav-like family member 2) gene is implied in immunity (Mallory et al. 2015) and possible methylation-induced neurological disorders (Do et al. 2016) making it a good candidate to the stress response. Its expression has been shown to be regulated by glucocorticoid receptor signaling in zebrafish, even though its precise function was not investigated (Nesan and Vijayan 2013). A role in immune T-cells is recognized, promoting antigen signalling (Ajith et al. 2016).","Mallory MJ, Allon SJ, Qiu J et al. 2015. Proc Natl Acad Sci USA 112(17): E2139-E2148     /       Do C, Lang CF, Lin J, et al. 2016. Am J Hum Genet. 98(5): 934-955     /     Nesan D, Vijayan MM. 2013. PLoS ONE 8(11): e80726    /      Ajith S, Gazzara MR, Cole BS, et al. 2016. RNA Biol. 13(6): 569-581","doi:10.1073/pnas.1423695112     doi:10.1016/j.ajhg.2016.03.027   doi:10.1371/journal.pone.0080726    doi:10.1080/15476286.2016.1176663"]
["LGx","MYF5",null,null,"X",null,"X",{"$nulls":4},"The myogenic factor 5 (MYF5) gene has a well recognized role in myogenesis that extends after the embryonic and larval phases (e.g. Guo et al. 2009), but its transcription has been shown to respond to cortisol level, then to stress (Pandurangan et al. 2014). MYF5 is an early axonal marker in the brain (Daubas et al. 2000), but relationship to, e.g., early life stress is not assessed. One interaction is reported with GLI2 (LG24) in our STRING search, but certainly due to the roles of these two genes during early development (Himeda et al. 2013).","Guo Y, Bai J, Chang O et al. 2009. Mol Biol Rep. 36(6):1497-1504     /     Pandurangan M, Moorthy H, Sambandam R et al. 2014. Cytotechnology 66(5): 839-844    /     Daubas P, Tajbakhsh S, Hadchouel J et al. 2000. Development 127(2): 319-331    /     Himeda CL, Barro MV, Emerson CP Jr. 2013. Dev Biol. 383(1): 7‐14 ","doi:10.1007/s11033-008-9341-1      doi:10.1007/s10616-013-9635-6            PMID:10603349        doi:10.1016/j.ydbio.2013.09.006"]
["UN","BTR30","(CP - infected cells)",null,null,"X",{"$nulls":5},"As other genes of the BTR family in zebrafish (Zhang et al. 2015), it is known that variation at BTR30/TRIM39 (bloodthirsty-related gene family member 30 gene, also known as the E3 ubiquitin-protein ligase TRIM39-like) is implicated in the immune response in fish, notably during pathogen challenges (e.g. Epinephelus coioides: Wang et al. 2016; Lateolabrax japonicus: Zhang et al. 2018; Salmo salar, Robledo et al. 2020), including a athogen challenge on sea bass cultured cells (Chavez-Pozo et al. 2019, ref. on sheet 1). It has been found to interact with ROBO3 (LG14, supra) in the immune response (Zhang et al. 2018)","Zhang X, Zhao H, Chen Y et al. 2015. Biochem Biophys Res Commun. 457(1):83-89      /      Wang W, Huang Y, Yu Y et al. 2016. Fish Shellfish Immunol. 50: 1-10     /     Zhang W, Jia P, Liu W et al. 2018. Fish Shellfish Immunol. 75:1-7     /     Robledo D, Hamilton A, Gutiérrez AP et al. 2020. BMC Genomics. 21(1): 271","doi: 10.1016/j.bbrc.2014.12.081            doi:10.1016/j.fsi.2016.01.016    doi: 10.1016/j.fsi.2018.01.039          doi:10.1186/s12864-020-6694-x"]
["UN","CRTC2","(W - brain)",null,"X","X",null,"X","X","X",null,"This complements the main text: A role of CRTC2 (or TORC2, a CREB co-activator) in Th1 and Th2 cell differentiation has been reported (Delgoffe et al. 2011; Yao et al. 2013). In mammals, CRTC2 is expressed in liver and recognized as one sensitive hepatic glucose sensor (e.g. Dentin et al. 2008; Tsai et al. 2013). It mediates the action of thyroid stimulating hormone in gluconeogenesis (Li et al. 2017). Its role on glucose homeostasis when facing stress has been repeatedly reported (Erion et al. 2013; Anyamaneeratch et al. 2015; Hogan et al. 2015), notably in relation to glucocorticoids (Hill et al. 2016) as well as in stress resistance in Drosophila (Wang et al. 2008). ","Delgoffe GM, Kole TP, Zheng Y et al. 2009. Immunity 30(6): 832-844     /    Yao C, Hirata T, Soontrapa K, et al. 2013. Nat Commun. 4:1685    /    Dentin R, Hedrick S, Xie J et al. 2008.  Science.319(5868):1402-1405     /       Tsai WW, Niessen S, Goebel N et al. 2013. Proc Natl Acad Sci USA 110(22): 8870‐8875.      /      Li Y, Wang L, Zhou L et al. 2017. Mol Cell Endocrinol. 446:70-80    /     Erion DM, Kotas ME, McGlashon J et al. 2013. J Biol Chem. 288(22):16167-16176    /      Anyamaneeratch K, Rojvirat P, Sukjoi W et al. 2015. Int Rev Cell Mol Biol. 318: 203-253      /     Hogan MF, Ravnskjaer K, Matsumura S et al. 2015. J Biol Chem. 290(43): 25997-26006   /     Hill MJ, Suzuki S, Segars JH et al. 2016. Mol Endocrinol. 30(1):104-117    /    Wang B, Goode J, Best J et al. 2008. Cell Metab. 7(5): 434-444 ","doi:10.1016/j.immuni.2009.04.014      doi:10.1038/ncomms2684     doi:10.1126/science.1151363    doi:10.1073/pnas.1304602110     doi:10.1016/j.mce.2017.02.015    doi:10.1074/jbc.M113.460246     doi:10.1016/bs.ircmb.2015.05.004   doi:10.1074/jbc.M115.679266     doi:10.1210/me.2015-1237     doi:10.1016/j.cmet.2008.02.010"]
["UN","DENND4B","(W - brain)           (B - brain)",null,"X","X",null,"X",null,"X"]
["UN","DLG1","( R - brain )        (GP - brain)    (O  - brain)     (V  -  brain)",null,"X","X","X","X",null,"X",null,"The Disk large Homolog 1 (DLG1, also know as SAP97) gene that plays a critical role in neural synapse formation, insulin secretion and glucose transport and others (Walch 2013). Adrenergic modulation implying DLG1 was also found to correlate with emotional states and sensitivity in mice (Liu et al. 2017), and it has been proposed that the Dlg1 protein is involved in the regulation of T-cell proliferation, migration and antigen signaling (e.g. Gmyrek et al. 2013; Marziali et al. 2019). Associations with PRKCQ and NCBP2 are known (see these genes in this Table for additional information) and participation to the regulation of BDNF is present as DLG1 activates the Glutamate receptor 1 (GluR1; Walch 2013) that interacts with molecular processing of BDNF (Jourdi and Kabbaj 2013). DLG1 has also interact with the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR, e.g. Cai et al. 2002, Howard et al. 2010) that is itself associated to the action of BDNF (e.g. Li and  Wolf  2011). Synaptic transmission, trafficking and plasticity might be regulated owing to DLG1, being important for stress response processing.","Walch L. 2013. Traffic. 14(9): 964‐973      /    Liu Y, Cui L, Schwarz MK et al. 2017. Neuron 18: 93(2): 394-408      /     Gmyrek GB, Graham DB, Sandoval GJ et al. 2013. Eur J Immunol. 43(5): 1185-1194     /    Marziali F, Dizanzo MP, Cavatorta AL et al. 2019. Biol Chem. 400(6): 699-710     /     Jourdi H, Kabbaj M. 2013. PLoS One 8(2): e57124        /      Cai C, Coleman SK, Niemi K, Keinänen K. 2002. J Biol Chem. 277(35): 31484-31490      /      Howard MA, Elias GM, Elias LA, Swat W, Nicoll RA. 2010. Proc Natl Acad Sci USA. 2010;107(8):3805-3810     /     Li X., Wolf ME. 2011. Eur J Neurosci. 34(2): 190-198 ","doi:10.1111/tra.12089                 doi:10.1016/j.neuron.2016.12.039              doi:10.1002/eji.201142362    doi:10.1515/hsz-2018-0350     doi:10.1371/journal.pone.0057124       doi:10.1074/jbc.M204354200         doi:10.1073/pnas.0914422107     doi:10.1111/j.1460-9568.2011.07754.x"]
["UN","GFRA2","(W - brain)",null,"X",null,"X","X",null,"X",null,"Despite a ubiquitous expression in bony fishes, the glial cell line-derived neurotrophic factor (GDNF) receptor-alpha2 gene (GFRA2) gene is involved in dopaminergic activity in the brain (e.g. Saarenpää et al. 2017; Mamta and Senthilkumaran 2018). Outside fish, it has been shown to respond to stress and then to translate in symptoms ranging from cachexia/anorexia to obesity due to dysregulation of the glucose metabolism (Breit et al. 2017), but also with resilience to acute stress (Azadmarzabadi et al. 2018). The expression of GFRA2 participates to maintain one integrated stem cell complex that accompanies pituitary cell renewal during life and postnatal pituitary homeostasis when stimulated (Garcia-Lavandeira et al. 2009). A role in growth hormone regulation has been postulated, and more generally in the regulation of most pituitary hormones (Garcia-Lavandeira et al. 2009, 2010). GFRA2 has been found associated to NPAS3 in various health disorders (Lavedan et al. 2009)","Saarenpää T, Kogan K, Sidorova Y et al. 2017. PLoS ONE 12(5): e0176166     /     Mamta SK, Senthilkumaran B. 2018. Brain Res Bull. 140: 270-280    /   Breit SN, Tsai VW, Brown DA. 2017. Trends Mol Med. 23(12): 1065-1067   /    Azadmarzabadi E, Haghighatfard A, Mohammadi A.. 2018. Psychogeriatrics 18(3): 190-201    /     Garcia-Lavandeira M, Quereda V, Flores I et al. 2009. PLoS One. 4(3): e4815    /    Garcia-Lavandeira M, Diaz-Rodriguez E, Garcia-Rendueles MER. et al. 2010. Front Horm Res. 38:127-138      /      Lavedan C., Licamele L, Volpi S, Hamilton J et al. 2009. Mol. Psychiatry 14(8): 804-819  ","doi:10.1371/journal.pone.0176166    doi:10.1016/j.brainresbull.2018.05.010    doi:10.1016/j.molmed.2017.10.005      doi:10.1111/psyg.12312      doi:10.1371/journal.pone.0004815     doi:10.1159/000318502     doi:10.1038/mp.2008.56."]
["UN","GMPPB","(W - brain)",null,"X",null,null,"X",null,"X",null,"The GDP mannose pyrophosphorylase B (GMPPB) gene  is known, when mutated, to participate to the development of neuropathies affecting seizure, psychomotor delays and other impairments. A link with corticosteroid is established: treatments allow for recoveries  (Fecarotta et al. 2018).","Fecarotta S, Gragnaniello V, Della Casa R et al. 2018. Neuromuscul Disord. 28(11): 956-960 ","doi:10.1016/j.nmd.2018.07.001"]
["UN","MATR3","(W - brain)",null,"X",null,null,"X",null,"X"]
["UN","NPAS3","(W - brain)",null,"X",null,null,"X","X","X",null,"This complements the main text: Behavioural and memory deficits linked with the NPAS3 gene have been reported by various authors (e.g.Luoma et al. 2018). NPAS3 participates to a brain neurosignaling pathway that also includes BDNF which is activated by AC/ADCY1 (Yang et al. 2016). NPAS3 has been shown also implicated in glucose metabolism in the brain (Sha et al. 2012), but also ùetabolic syndrome and insulin resistance (Zhang et al. 2013). Impairment in behaviours have been reported in NPAS3 K-O mice associated to a dysregulation of several hormonal pathways (e.g. Brunskill et al. 2005; Michaelson et al. 2017).","Luoma LM, Macintyre G, Tibbo PG et al. 2018. Psychiatry Res. 265: 263-264    /     Yang D, Zhang W, Padhiar A et al. 2016. Front Mol Neurosci. 9: 109    /     Sha L, MacIntyre L, Machell JA et al. Mol Psychiatry 17(3): 267-279      /      Zhang Y, Kent JW Jr, Olivier M, et al. 2013. BMC Med Genomics. 6: 14    /     Brunskill EW, Ehrman LA, Williams MT et al. 200. Eur J Neurosci. 22(6): 1265-1276     /     Michaelson JJ, Shin MK, Koh JY et al. 2017. Biol Psychiatry 82(3): 213-223 ","doi:10.1016/j.psychres.2018.04.063   doi:10.3389/fnmol.2016.00109         doi:10.1038/mp.2011.73      doi:10.1186/1755-8794-6-14     doi:10.1111/j.1460-9568.2005.04291.x    doi:10.1016/j.biopsych.2017.03.021"]
["UN","PRKCQ","(W - brain)          (AP - testis)",null,"X","X",null,"X","X","X",null,"The role of PRKCQ (or PKC-theta, a protein kinase C theta type) in the immune response is well-known in Vertebrates (e.g. van Hamburg and Tas 2018), including fish in which PRKCQ has been shown to respond to pathogenic stress (Mehjabin et al. 2019). PRKCQ is also known to participate to glucose metabolism, including glucose homeostasis (Haasch et al. 2006; Park-York et al. 2013). One association with DLG1 is reported, also related to the immune response (Zanin-Zhorov et al. 2017). ","van Hamburg JP, Tas SW. 2018. J Autoimmun. 87: 69-81     /     Mehjabin R, Chen L, Huang R et al. 2019. Fish Shellfish Immunol. 87: 788-795     /   Haasch D, Berg C, Clampit JE et al. 2006. Biochem Biophys Res Commun. 343(2): 361-8     /     Park-York M, Boghossian S, Oh H et al. 2013. Brain Res. 1498: 85-94     /    Zanin-Zhorov A, Kumari S, Hippen KL et al. 2017. Sci Rep. 7(1): 4258 ","doi:10.1016/j.jaut.2017.12.006       doi:10.1016/j.fsi.2019.01.057    doi:10.1016/j.bbrc.2006.02.177      doi:10.1016/j.brainres.2012.12.042     doi:10.1038/s41598-017-04053-5"]
["UN","PTPRB","(W - brain )",null,"X","X",null,"X",null,"X",null,"The receptor-type tyrosine-protein phosphatase beta-like (PTPRB) has a role in immune response regulation (Brunner et al. 2003). It is implied in neuronal differentiation and its expression may react to several stressors in the brain (e.g. drugs; Ishiguro et al. 2008) certainly because of its transporter function, notably in the hippocampus (Dobryakova et al. 2019). Very probably found in Sagonas et al. (2020, response to pathogen stress in stickleback) as PTPREB as annotation score is low and misleading.","Brunner R, Rottengatter K, Horstmann RD et al. 2003. Cytogenet Genome Res. 103(1-2): 203G    /     Ishiguro H, Gong JP, Hall FS et al. 2008. Am J Med Genet B Neuropsychiatr Genet. 147B(7): 1167-1172     /       Dobryakova YV, Volobueva MN, Manolova AO et al. 2019. Front Neurosci. 13: 146       /     Sagonas K, Meyer BS, Kaufmann J et al. 2020. Mol. Biol. Evol. doi:10.1093/molbev/msaa084 ","doi:10.1159/000076319       doi:10.1002/ajmg.b.30742     doi:10.3389/fnins.2019.00146      doi:10.1093/molbev/msaa084"]
[]
["*: linked to a gene body and an intergenic DMC (Table 1 of the main text or Suppl. Mat. Table S3)"]