{"text_format":"3","workbook":"xlsx","n_sheets":11,"sheets":["Table S1","Table S2","Table S3","Table S4","Table S5","Table S6","Table S7","Table S8","Table S9","Table S10","Table S11"],"not_rendered":{"defined_names":2},"read":"whole","date_system":"1900"}

{"sheet":"Table S1","index":0,"n_rows":16,"n_cols":8,"rows_kept":16}
["Table S1. Primer information of Sanger sequencing"]
["Genes","Chr","position","Reference allele","Alternative allele","Mutation","Sequences(5' - 3')","Fragment size (bp)"]
["EPB41L5","chr2",184372074,"G","A","exon19:c.G1745A:p.R582H","F: GTGAATAGGACTGCACTGGGT",381]
[{"$nulls":6},"R: GAGTGAGTCAAACTATCTTTCCAAC"]
["CPS1","chr2",211281967,"T","C","exon30:c.T3600C:p.G1200G","F: CCCTCACTGGAGACTTAGCAAAT",365]
[{"$nulls":6},"R: CACAGCAAACTCAGAGGAAGAAG"]
["KDM4B","chr5",16765965,"A","G","exon1:c.T93C:p.Y31Y","F: TCAAGGAGCGGATTAATGGGT",312]
[{"$nulls":6},"R: CTGGCAATGGTGGTGCTGAC"]
["KDM4B","chr5",16757840,"G","A","exon5:c.C555T:p.A185A","F: AACCACAAGCTCTGGGGATCT",352]
[{"$nulls":6},"R: AGTGGGCTGACCGTGTGCT"]
["KDM4B","chr5",16688331,"A","C","exon21:c.T2806G:p.S936A","F: CCGCTCACAGTGATGCTCTC",315]
[{"$nulls":6},"R: AGCCGGATGACTGGCCCTAC"]
["HERC5","chr6",36197551,"T","C","exon23:c.A3002G:p.K1001R","F: TTCCCAAAAGGGGTAAAGAGTG",351]
[{"$nulls":6},"R:  ATGCAGTCCAAAGCACATGG"]
["C11orf80","chr21",44120939," G","T","exon6:c.G606T:p.Q202H","F: AATGTGGAAAGGGCTTAATATGT ",313]
[{"$nulls":6},"R: AGAGAGAGAGATTTACCGCTGTC"]

{"sheet":"Table S2","index":1,"n_rows":18,"n_cols":8,"rows_kept":18}
["Table S2. Sample information and sequencing quality"]
["Group","Sample","Total Bases","Raw Read Pairs","HQ filtered read pairs","N filtered and trimmed read pairs","Q30(%)","Q20(%)"]
["Polytocous","P1",18665951976,74071238,65271972,65178442,86.9,92.42]
[null,"P2",18356631552,72843776,64278625,64187047,86.94,92.45]
[null,"P3",18989066376,75353438,65737618,65644649,86.34,91.99]
[null,"P4",17401824972,69054861,60748712,60661304,86.61,92.28]
[null,"P5",17749238472,70433486,61795296,61707113,86.48,92.19]
["Monotocous","M1",16294728744,64661622,58619871,56170206,88.9,93.7]
[null,"M2",18959435712,75235856,68740954,65866437,89.64,94.13]
[null,"M3",16094711304,63867902,58388916,56944640,90.33,94.18]
[null,"M4",18053328636,71640193,65417702,63797480,90.28,94.12]
[null,"M5",19597148676,77766463,67978338,66368979,87.75,92.21]
[]
[]
[]
[]
[]
[null,"M5"]

{"sheet":"Table S3","index":2,"n_rows":17,"n_cols":11,"rows_kept":17}
["Table S3. Reads mapping statistics and coverage of depth for Monotocous and Polytocous sheep."]
["Group","Sample ID","Total reads after QC","Duplicates removed","Mapped Readsa","Unmapped","Mapped to chromosomesb","Mapping rate(%)c","Average depthd","Coverage at least 1X(%)d","Coverage at least 4X(%)d"]
["Polytocous","P1",130356884,{"$f":"C3-E3-F3","v":4067124},121479920,4809840,118472662,93.81,5.67,93.9,73.59]
[null,"P2",128374094,3405498,120658324,4310272,117784487,94.25,5.64,93.57,73.03]
[null,"P3",131289298,5217677,120714955,5356666,116983984,92.79,5.61,88.29,64.75]
[null,"P4",121322608,3027037,114184134,4111437,111592954,94.33,5.35,94.55,71.42]
[null,"P5",123414226,3069461,116102285,4242480,113527643,94.34,5.44,94.21,71.77]
["Monotocous","M1",112340412,3553925,104723548,4062939,102094967,93.85,4.89,93.21,65.53]
[null,"M2",131732874,5727376,121069733,4935765,117550386,93.29,5.62,94.43,73.65]
[null,"M3",113889280,3927186,105445170,4516924,102588108,93.29,4.91,87.38,61.82]
[null,"M4",127594960,3547705,119466451,4580804,116576712,93.98,5.59,92.06,70.24]
[null,"M5",132737958,3828481,123627248,5282229,120694018,93.63,5.77,94.72,75.44]
[]
["a Mapped reads was calculated after PCR duplicates removed, one read could be mapped to >=2 positions."]
["b Reads only mapped to the  chromosomes"]
["c Mapping rate=Chromosomes mapped reads/(Mapped reads+Unmapped reads) "]
["dDepth and coverage are calculated only using reads mapped to autosomes"]

{"sheet":"Table S4","index":3,"n_rows":31,"n_cols":5,"rows_kept":31,"merged":[[1,0,2,0],[1,1,1,2],[1,3,1,4],[30,1,30,2],[30,3,30,4]]}
["Table S4. Number of SNPs and Indels in different chromosomes"]
["Chr","SNPs",null,"Indels"]
[null,"Polytocous","Monotocous","Polytocous","Monotocous"]
["chr1",2006925,2091648,197612,202884]
["chr2",1737079,1837296,171753,178282]
["chr3",1499477,1575965,150731,155445]
["chr4",858623,902882,85633,88531]
["chr5",751104,800638,75989,79483]
["chr6",884664,915752,88007,89955]
["chr7",700038,743169,69581,72430]
["chr8",653977,700586,65373,68551]
["chr9",722718,764186,70570,73159]
["chr10",651206,672810,64220,65393]
["chr11",407936,441172,41064,43176]
["chr12",575494,603623,57056,58921]
["chr13",563380,584543,54624,56156]
["chr14",430020,454796,43086,44810]
["chr15",590537,634012,57200,60090]
["chr16",554406,563625,53731,54213]
["chr17",538083,561884,53464,55221]
["chr18",496011,531707,48448,50598]
["chr19",428503,448990,42016,43396]
["chr20",383799,412300,37790,39799]
["chr21",403695,419111,37908,38839]
["chr22",381109,406274,36408,38188]
["chr23",495296,513273,48364,49498]
["chr24",309471,325568,29695,30676]
["chr25",361926,386650,34385,35970]
["chr26",355234,374846,34993,36385]
["chrX",552222,586495,65503,67813]
["Total",21391472,null,2043106]

{"sheet":"Table S5","index":4,"n_rows":27,"n_cols":4,"rows_kept":27,"merged":[[1,0,1,1],[2,0,2,1],[3,0,3,1],[4,0,4,1],[5,0,5,1],[6,0,6,1],[7,0,7,1],[8,0,8,1],[9,0,9,1],[10,0,10,1]]}
["Table S5. Number of annotated SNPs in different gene regions"]
["Group",null,"Polytocous","Monotocous"]
["3'UTR",null,39825,41465]
["5'UTR",null,6986,7400]
["5'UTR; 3'UTR",null,36,40]
["Downstream",null,103941,110088]
["Intergenic",null,14257852,14968453]
["Intronic",null,5466707,5758792]
["Splicing",null,1255,1296]
["Upstream",null,110964,116709]
["Upstream;Downstream",null,1333,1416]
["Exonic(exonic;splicing)","Synonymous_SNP",68339,72516]
[null,"Nonsynonymous_SNP",45775,48265]
[null,"Stopgain",742,785]
[null,"Stoploss",45,52]
[null,"Frameshift_deletion",1128,1152]
[null,"Frameshift_insertion",1734,1752]
[null,"Frameshift_substitution",1,1]
[null,"Nonframeshift_deletion",661,659]
[null,"Nonframeshift_insertion",812,821]
["Tsa",null,7760753,7705613]
["Tva",null,3187638,3164268]
["Ts/Tv",null,2.434640633597667,2.4351960706236007]
["Homo.",null,14969223,14959022]
["Hete.(%)",null,"6422248(30.02%)","6432449(30.07%)"]
["Total",null,{"$f":"SUM(C3:C20)","v":20108136},{"$f":"SUM(D3:D20)","v":21131662}]
["a Ts and Tv were calculated with the biallele SNPs in Exonic(exonic;splicing)"]

{"sheet":"Table S6","index":5,"n_rows":89,"n_cols":7,"rows_kept":89}
["Table S6. Genomic regions and genes highly differentiated (Z(FST)>5) between Monotocous and Polytocous sheep"]
["Chromosome","bin_start","bin_end","Fst","Zscore","Gene","Associated gene name"]
[1,33200000,33250000,0.330004,5.24871722296704,"ENSOARG00000009999","C-JUN"]
[1,40250000,40300000,0.3402371,5.4144613289708]
[1,103400000,103450000,0.3741001,5.96293565850977,"ENSOARG00000002952","ADAR"]
[1,107850000,107900000,0.3354479,5.33689131866374,"ENSOARG00000007107,ENSOARG00000007488","OR10Z1,SPTA1"]
[1,107900000,107950000,0.41137,6.56659107635475,"ENSOARG00000007488","ENSOARG00000007488"]
[1,185150000,185200000,0.3274676,5.20763550281695,"ENSOARG00000021501,ENSOARG00000020139","U6,KPNA1"]
[1,274800000,274850000,0.3216933,5.11410996399709,"ENSOARG00000015658","KCNH8"]
[2,36900000,36950000,0.4169027,6.6562034533751,"ENSOARG00000009268","FAM219A"]
[2,52800000,52850000,0.33604849999999997,5.34661915383254,"ENSOARG00000012072","UNC13B"]
[2,70600000,70650000,0.3649156,5.81417558174012,"ENSOARG00000013337","KIAA0020"]
[2,109650000,109700000,0.3283198,5.22143846840279]
[2,147050000,147100000,0.3361198,5.34777399007552]
[2,147100000,147150000,0.3570601,5.6869411342401]
[2,147150000,147200000,0.3442681,5.4797508786968]
[2,159750000,159800000,0.3418296,5.44025483131232]
[2,163300000,163350000,0.3571747,5.68879729459698]
[2,167200000,167250000,0.3622764,5.77142882420183]
[2,184200000,184250000,0.3644453,5.80655819765773,"ENSOARG00000012857,ENSOARG00000012888","PTPN4,EPB41L5"]
[2,184300000,184350000,0.4251533,6.78983728095371,"ENSOARG00000012888","EPB41L5"]
[2,184350000,184400000,0.4515802,7.21787012681182,"ENSOARG00000012888","EPB41L5"]
[2,184900000,184950000,0.378589,6.03564175123243]
[2,193350000,193400000,0.3205564,5.0956957518702,"ENSOARG00000014195,ENSOARG00000024578","TMEFF2,U6"]
[2,199050000,199100000,0.4371049,6.98341569387985,"ENSOARG00000015701","ENSOARG00000015701"]
[2,207100000,207150000,0.3379357,5.37718587133264,"ENSOARG00000018495","INO80D"]
[2,211250000,211300000,0.3403764,5.41671755181298,"ENSOARG00000019210","CPS1"]
[2,247500000,247550000,0.3494787,5.56414624654654]
[3,60750000,60800000,0.3703391,5.90201926145706,"ENSOARG00000020932","C2orf40"]
[3,62850000,62900000,0.3200987,5.08828244824589,"ENSOARG00000001290,ENSOARG00000001316","PEX13,PUS10"]
[3,133750000,133800000,0.3399644,5.41004444477078,"ENSOARG00000016989,ENSOARG00000017049,ENSOARG00000017035","ENSOARG00000016989,ENSOARG00000017049,KRT75"]
[3,164000000,164050000,0.3213496,5.10854310261262,"ENSOARG00000018181","ENSOARG00000018181"]
[3,174400000,174450000,0.3355653,5.33879283023353,"ENSOARG00000024684","5S_rRNA"]
[3,177350000,177400000,0.3590592,5.71932028057035]
[3,177400000,177450000,0.4,6.3824327582241]
[3,178450000,178500000,0.3303417,5.254186903181]
[3,180650000,180700000,0.3228923,5.13353000123884,"ENSOARG00000019234","MFNG"]
[3,183650000,183700000,0.3643796,5.80549406384056]
[3,184000000,184050000,0.3593505,5.72403842639897]
[3,184900000,184950000,0.3487568,5.55245373204711,"ENSOARG00000019588","OVCH1"]
[3,194900000,194950000,0.3670999,5.84955438686701]
[4,24500000,24550000,0.3421514,5.44546698142441]
[4,28550000,28600000,0.3324017,5.28755243839201]
[4,78900000,78950000,0.3339506,5.3126397575611]
[4,117550000,117600000,0.3709693,5.91222652373374,"ENSOARG00000007063,ENSOARG00000006987","LMBR1,RNF32"]
[4,117900000,117950000,0.3466682,5.51862496658998,"ENSOARG00000007377","UBE3C"]
[4,117950000,118000000,0.3256131,5.17759842269617,"ENSOARG00000007377","UBE3C"]
[5,16700000,16750000,0.4049001,6.46179900049956,"ENSOARG00000008388","KDM4B"]
[5,16750000,16800000,0.6639187,10.6570874561332,"ENSOARG00000008388","KDM4B"]
[5,27550000,27600000,0.3625592,5.77600929670555,"ENSOARG00000018762","CSNK1G3"]
[6,36200000,36250000,0.3340465,5.31419303660321,"ENSOARG00000000530","HERC5"]
[8,50900000,50950000,0.4026094,6.42469684928216]
[8,50950000,51000000,0.3270514,5.20089436895539,"ENSOARG00000013186,ENSOARG00000013234","SYNCRIP,SNX14"]
[8,51000000,51050000,0.3289093,5.23098651840613,"ENSOARG00000013234","SNX14"]
[8,55750000,55800000,0.3232527,5.13936735021459]
[8,55800000,55850000,0.333438,5.30433724622656]
[9,9300000,9350000,0.3224325,5.12608268420485]
[9,34800000,34850000,0.3900134,6.22068117864244,"ENSOARG00000013906,ENSOARG00000013994","TCEA1,LYPLA1"]
[9,34850000,34900000,0.4384565,7.00530737222509,"ENSOARG00000014089","ENSOARG00000014089"]
[9,34900000,34950000,0.381291,6.07940567168881]
[10,24750000,24800000,0.3519775,5.60461896469473]
[10,46300000,46350000,0.3260201,5.18419054542961]
[10,46350000,46400000,0.3240289,5.1519393543072]
[11,34700000,34750000,0.3216537,5.11346856827168,"ENSOARG00000002423","DHRS7B"]
[11,44950000,45000000,0.4060793,6.4808983398786,"ENSOARG00000010947","NSF"]
[11,54800000,54850000,0.3346924,5.32465458960941,"ENSOARG00000009764,ENSOARG00000009548,ENSOARG00000009600","ITGB4,UNK,GALK1"]
[14,37600000,37650000,0.3156923,5.01691259661785,"ENSOARG00000003669","ZFHX3"]
[14,41550000,41600000,0.340796,5.42351375500451,"ENSOARG00000022989","SNORA70"]
[14,48000000,48050000,0.3773404,6.01541834964774,"ENSOARG00000021360,ENSOARG00000005978","5S_rRNA,ENSOARG00000005978"]
[14,48050000,48100000,0.3574643,5.69348790576062,"ENSOARG00000005985,ENSOARG00000005992,ENSOARG00000011330","PAK4,NCCRP1,SYCN"]
[15,16350000,16400000,0.3529115,5.61974683357195,"ENSOARG00000010464","ALKBH8"]
[15,46300000,46350000,0.335631,5.3398569640507,"ENSOARG00000018914,ENSOARG00000017416,ENSOARG00000017400","ENSOARG00000018914,ENSOARG00000017416,ENSOARG00000017400"]
[15,76100000,76150000,0.3810957,6.07624242458847,"ENSOARG00000008355","ENSOARG00000008355"]
[16,23200000,23250000,0.3191909,5.0735789371466]
[16,23250000,23300000,0.3669206,5.84665028955472,"ENSOARG00000007507","IL6ST"]
[16,24050000,24100000,0.4285292,6.84451626654537,"ENSOARG00000007957,ENSOARG00000007970,ENSOARG00000007978","CDC20B,GZMA,ENSOARG00000007978"]
[17,54100000,54150000,0.3164766,5.02961579529066,"ENSOARG00000017389","HVCN1"]
[18,19300000,19350000,0.3658452,5.82923218442563,"ENSOARG00000011119","ENSOARG00000011119"]
[19,48000000,48050000,0.3732502,5.94916994570597,"ENSOARG00000000541,ENSOARG00000000606,ENSOARG00000000729","ENSOARG00000000541,ENSOARG00000000606,ITIH4"]
[19,48050000,48100000,0.3201222,5.08866307449709,"ENSOARG00000001064,ENSOARG00000001533,ENSOARG00000000729","ITIH3,ITIH1,ITIH4"]
[21,44100000,44150000,0.4092228,6.53181317479889,"ENSOARG00000008338,ENSOARG00000008536","C11orf80,RCE1"]
[24,37700000,37750000,0.3272026,5.20334333445243,"ENSOARG00000000869","LMTK2"]
[24,40350000,40400000,0.3177015,5.04945533125181,"ENSOARG00000004356,ENSOARG00000004437","CARD11,GNA12"]
[24,40400000,40450000,0.3356729,5.34053561255815,"ENSOARG00000004437","GNA12"]
[24,41000000,41050000,0.4126401,6.58716271046713,"ENSOARG00000005349","ENSOARG00000005349"]
[24,41400000,41450000,0.3304098,5.25528990946638]
[24,41850000,41900000,0.4115985,6.57029205926529]
["X",25850000,25900000,0.4454811,7.11908384729462]
["X",33850000,33900000,0.4002157,6.38592642130421,"ENSOARG00000018864","ENSOARG00000018864"]

{"sheet":"Table S7","index":6,"n_rows":200,"n_cols":7,"rows_kept":200}
["Table S7. Candidate regions and genes of 50-kb windows with value of |XP-EHH|>2 in Monotocous and Polytocous sheep"]
["Chr","Bin start","Bin end","xpEHH","|xpEHH|","Gene","Gene Name"]
[1,19050000,19100000,2.078,{"$f":"ABS(D3)","v":2.078},"ENSOARG00000000941,ENSOARG00000000963","ENSOARG00000000941,TMEM53"]
[1,25850000,25900000,2.034,2.034,"ENSOARG00000004769","ENSOARG00000004769"]
[1,25900000,25950000,2.305,2.305,"ENSOARG00000004769","ENSOARG00000004769"]
[1,48150000,48200000,-2.285,2.285]
[1,58100000,58150000,2.074,2.074]
[1,118100000,118150000,-2.333,2.333,"ENSOARG00000012286","ADCY10"]
[1,130750000,130800000,2.099,2.099]
[1,144750000,144800000,2.649,2.649,"ENSOARG00000016739","ENSOARG00000016739"]
[1,171800000,171850000,2.168,2.168,"ENSOARG00000019010","DZIP3"]
[1,173750000,173800000,2.342,2.342]
[1,176500000,176550000,2.006,2.006,"ENSOARG00000019412,ENSOARG00000019394","SPICE1,CFAP44"]
[1,179350000,179400000,2.022,2.022]
[1,187700000,187750000,-2.85,2.85,"ENSOARG00000020233","HEG1"]
[1,193400000,193450000,2.029,2.029,"ENSOARG00000020443","FGF12"]
[1,260800000,260850000,-2.72,2.72,"ENSOARG00000010806,ENSOARG00000010840","UBASH3A,RSPH1"]
[2,1700000,1750000,2.114,2.114,"ENSOARG00000005339","TSSC1"]
[2,16800000,16850000,2.539,2.539]
[2,16850000,16900000,2.128,2.128]
[2,122600000,122650000,2.071,2.071,"ENSOARG00000016675","ENSOARG00000016675"]
[2,123650000,123700000,2.058,2.058]
[2,133100000,133150000,2.02,2.02]
[2,160700000,160750000,2.178,2.178]
[2,160750000,160800000,2.341,2.341]
[2,186450000,186500000,2.305,2.305]
[2,190650000,190700000,2.19,2.19]
[2,190700000,190750000,2.437,2.437]
[2,190750000,190800000,2.12,2.12]
[2,190800000,190850000,2.171,2.171,"ENSOARG00000013576","ENSOARG00000013576"]
[2,193350000,193400000,2.295,2.295,"ENSOARG00000014195,ENSOARG00000024578","TMEFF2,U6"]
[2,211250000,211300000,2.226,2.226,"ENSOARG00000019210","CPS1"]
[2,218950000,219000000,-2.353,2.353,"ENSOARG00000019446","TNS1"]
[2,219700000,219750000,-2.308,2.308,"ENSOARG00000019716","CYP27A1"]
[2,232400000,232450000,2.015,2.015]
[2,247500000,247550000,2.489,2.489]
[3,8050000,8100000,2.013,2.013,"ENSOARG00000010878,ENSOARG00000010958,ENSOARG00000010974","ENSOARG00000010878,SLC25A25,NAIF1"]
[3,10450000,10500000,2.219,2.219,"ENSOARG00000012741","SIN1"]
[3,62850000,62900000,-2.922,2.922,"ENSOARG00000001290,ENSOARG00000001316","PEX13,PUS10"]
[3,62900000,62950000,-2.01,2.01,"ENSOARG00000001316","PUS10"]
[3,72450000,72500000,2.114,2.114]
[3,72500000,72550000,2.298,2.298]
[3,72650000,72700000,2.073,2.073]
[3,87000000,87050000,2.533,2.533,"ENSOARG00000010066","STRN"]
[3,87050000,87100000,2.175,2.175,"ENSOARG00000010066","STRN"]
[3,87150000,87200000,2.143,2.143,"ENSOARG00000010088","VIT"]
[3,87200000,87250000,2.128,2.128,"ENSOARG00000010088","VIT"]
[3,133250000,133300000,2.132,2.132,"ENSOARG00000016759,ENSOARG00000016737","EIF4B,TNS2"]
[3,133400000,133450000,2.699,2.699,"ENSOARG00000016811,ENSOARG00000016800,ENSOARG00000016824","ENSOARG00000016811,KRT78,KRT79"]
[3,133450000,133500000,2.398,2.398,"ENSOARG00000016836,ENSOARG00000016853","KRT4,KRT3"]
[3,137900000,137950000,2.309,2.309]
[3,169650000,169700000,-2.147,2.147,"ENSOARG00000014173","ANO4"]
[3,170300000,170350000,2.389,2.389,"ENSOARG00000014722,ENSOARG00000015007","UTP20,ARL1"]
[3,180500000,180550000,-2.242,2.242,"ENSOARG00000019218","CYTH4"]
[3,194900000,194950000,2.568,2.568]
[4,42800000,42850000,2.026,2.026,"ENSOARG00000017524","MAGI2"]
[4,63150000,63200000,-2.318,2.318]
[4,66900000,66950000,-2.108,2.108,"ENSOARG00000008903","CHN2"]
[4,78900000,78950000,-2.22,2.22]
[4,90200000,90250000,2.178,2.178]
[4,91400000,91450000,2.098,2.098]
[4,101850000,101900000,2.365,2.365]
[5,22550000,22600000,2.373,2.373,"ENSOARG00000017050","SLC27A6"]
[5,23100000,23150000,2.038,2.038,"ENSOARG00000017189","FBN2"]
[5,46800000,46850000,2.289,2.289,"ENSOARG00000015693","FAM13B"]
[5,80850000,80900000,2.123,2.123,"ENSOARG00000015677","HAPLN1"]
[5,80900000,80950000,2.611,{"$f":"ABS(D67)","v":2.611},null," "]
[5,101750000,101800000,2.316,2.316]
[6,6800000,6850000,2.333,2.333,"ENSOARG00000017247","METTL14"]
[6,18700000,18750000,2.423,2.423]
[6,36150000,36200000,-2.478,2.478,"ENSOARG00000000530,ENSOARG00000000388,ENSOARG00000000447","HERC5,ENSOARG00000000388,ENSOARG00000000447"]
[6,36200000,36250000,-3.963,3.963,"ENSOARG00000000530","HERC5"]
[6,95200000,95250000,-2.077,2.077,"ENSOARG00000019032","ENSOARG00000019032"]
[6,97200000,97250000,2.513,2.513]
[6,97250000,97300000,2.563,2.563,"ENSOARG00000001565","SEC31A"]
[6,97300000,97350000,2.306,2.306,"ENSOARG00000001821,ENSOARG00000001565","THAP9,SEC31A"]
[6,97350000,97400000,2.449,2.449,"ENSOARG00000001821,ENSOARG00000001916","THAP9,LIN54"]
[7,32900000,32950000,2.162,2.162,"ENSOARG00000020143,ENSOARG00000000786,ENSOARG00000020162","ENSOARG00000020143,ANKRD63,PLCB2"]
[7,33700000,33750000,2.26,2.26,"ENSOARG00000020330,ENSOARG00000020336","EXD1,CHP1"]
[7,35150000,35200000,2.067,2.067,"ENSOARG00000020571","TTBK2"]
[7,97700000,97750000,2.115,2.115]
[8,3500000,3550000,2.286,2.286]
[8,3550000,3600000,2.051,2.051]
[8,3600000,3650000,2.181,2.181]
[8,3650000,3700000,2.139,2.139]
[8,20050000,20100000,2.054,2.054]
[8,25000000,25050000,2.051,2.051]
[8,48750000,48800000,2.062,2.062]
[8,48800000,48850000,2.247,2.247]
[8,62900000,62950000,2.257,2.257,"ENSOARG00000000612","PERP"]
[8,63700000,63750000,2.201,2.201,"ENSOARG00000001051","REPS1"]
[8,76500000,76550000,2.089,2.089,"ENSOARG00000003999,ENSOARG00000004039","MTRF1L,RGS17"]
[8,76550000,76600000,2.217,2.217,"ENSOARG00000004039","RGS17"]
[8,76700000,76750000,2.101,2.101]
[8,77250000,77300000,2.413,2.413]
[9,36650000,36700000,2.032,2.032,"ENSOARG00000021816","U6"]
[9,68350000,68400000,2.25,2.25]
[9,84750000,84800000,2.117,2.117]
[10,33050000,33100000,2.018,2.018]
[10,33200000,33250000,2.257,2.257]
[10,60150000,60200000,2.452,2.452]
[10,60200000,60250000,2.389,2.389]
[11,14500000,14550000,2.032,2.032,"ENSOARG00000006966,ENSOARG00000007227","UNC45B,NLE1"]
[11,18550000,18600000,2.27,2.27]
[11,27950000,28000000,2.35,2.35,"ENSOARG00000021451","ENSOARG00000021451"]
[11,33100000,33150000,2.292,2.292,"ENSOARG00000017557","SPECC1"]
[11,33150000,33200000,2.261,2.261,"ENSOARG00000017557","SPECC1"]
[11,33200000,33250000,2.548,2.548]
[11,34700000,34750000,3.201,3.201,"ENSOARG00000002423","DHRS7B"]
[11,41000000,41050000,2.027,2.027,"ENSOARG00000015961,ENSOARG00000016036","KRTAP16-1,KIFI"]
[11,41150000,41200000,2.862,2.862,"ENSOARG00000016666,ENSOARG00000016951,ENSOARG00000016784,ENSOARG00000016865","KRT32,KRT13,KRT35,KRT36"]
[11,42050000,42100000,2.301,2.301,"ENSOARG00000022723,ENSOARG00000001896","SNORA31,ATP6V0A1"]
[11,44200000,44250000,-2.141,2.141,"ENSOARG00000009804,ENSOARG00000009593,ENSOARG00000009749","ACBD4,ENSOARG00000009593,ENSOARG00000009749"]
[11,44250000,44300000,-2.343,2.343,"ENSOARG00000009856,ENSOARG00000009972","HEXIM2,FMNL1"]
[11,44300000,44350000,-2.883,2.883,"ENSOARG00000010214,ENSOARG00000010296,ENSOARG00000010396,ENSOARG00000009972","ENSOARG00000010214,SPATA32,MAP3K14,FMNL1"]
[11,44950000,45000000,2.898,2.898,"ENSOARG00000010947","NSF"]
[11,51150000,51200000,2.401,2.401]
[12,24950000,25000000,2.076,2.076]
[12,25000000,25050000,2.092,2.092]
[12,26700000,26750000,2.185,2.185,"ENSOARG00000017329,ENSOARG00000016755","ENAH,ENSOARG00000016755"]
[12,39450000,39500000,2.339,2.339,"ENSOARG00000015889","VPS13D"]
[12,48100000,48150000,2.17,2.17]
[12,48150000,48200000,2.224,2.224]
[13,39650000,39700000,-2.117,2.117,"ENSOARG00000004116","KIZ"]
[13,49400000,49450000,-2.139,2.139]
[13,53550000,53600000,2.691,2.691,"ENSOARG00000011265,ENSOARG00000011406,ENSOARG00000011195","COL20A1,ARFGAP1,CHRNA4"]
[13,58050000,58100000,2.513,2.513,"ENSOARG00000017959,ENSOARG00000017883","RAE1,RBM38"]
[13,58100000,58150000,2.091,2.091,"ENSOARG00000018002","SPO11"]
[13,73200000,73250000,2.075,2.075,"ENSOARG00000005396,ENSOARG00000005277,ENSOARG00000005422,ENSOARG00000005370,ENSOARG00000005272","ENSOARG00000005396,SYS1-DBNDD2,DBNDD2,TP53TG5,ENSOARG00000005272"]
[14,14350000,14400000,2.456,2.456]
[14,16250000,16300000,2.142,{"$f":"ABS(D131)","v":2.142},"ENSOARG00000016864,ENSOARG00000016927","LONP2,SIAH1"]
[14,41600000,41650000,2.213,2.213]
[15,2450000,2500000,2.526,2.526]
[15,2650000,2700000,2.118,2.118]
[15,17250000,17300000,2.297,2.297,"ENSOARG00000011112,ENSOARG00000011428","ACAT1,NPAT"]
[15,17300000,17350000,2.161,2.161,"ENSOARG00000011428,ENSOARG00000011894","NPAT,ATM"]
[15,17350000,17400000,2.054,2.054,"ENSOARG00000011894","ATM"]
[15,28500000,28550000,2.164,2.164,"ENSOARG00000009505,ENSOARG00000008984,ENSOARG00000009172,ENSOARG00000009256","UBE4A,CD3E,CD3D,CD3G"]
[15,46300000,46350000,2.612,2.612,"ENSOARG00000018914,ENSOARG00000017416,ENSOARG00000017400","ENSOARG00000018914,ENSOARG00000017416,ENSOARG00000017400"]
[15,61550000,61600000,2.511,2.511,"ENSOARG00000016714","CCDC73"]
[15,61600000,61650000,3.061,3.061,"ENSOARG00000016714","CCDC73"]
[15,67900000,67950000,-2.329,2.329]
[15,75300000,75350000,2.24,2.24,"ENSOARG00000005192,ENSOARG00000005293,ENSOARG00000005460,ENSOARG00000005614","ARFGAP2,PACSIN3,DDB2,ACP2"]
[15,76050000,76100000,2.467,2.467,"ENSOARG00000008199","PTPRJ"]
[16,27250000,27300000,2.562,2.562]
[16,29400000,29450000,-2.09,2.09,"ENSOARG00000021556,ENSOARG00000008505","U6,HCN1"]
[16,29450000,29500000,-2.017,2.017,"ENSOARG00000008505","HCN1"]
[16,29800000,29850000,-2.68,2.68]
[16,30100000,30150000,-2.003,2.003]
[16,30150000,30200000,-2.389,2.389]
[16,30800000,30850000,-2.216,2.216]
[16,30850000,30900000,-2.359,2.359]
[16,31700000,31750000,-2.098,2.098,"ENSOARG00000008801,ENSOARG00000008775","CCDC152,SEPP1"]
[16,40950000,41000000,-2.354,2.354,"ENSOARG00000012154","SUB1"]
[17,9400000,9450000,2.31,2.31]
[17,52600000,52650000,2.227,2.227,"ENSOARG00000011159","CLIP1"]
[17,54100000,54150000,2.155,2.155,"ENSOARG00000017389","HVCN1"]
[17,62700000,62750000,-2.036,2.036]
[18,17250000,17300000,2.006,2.006]
[18,17350000,17400000,2.025,2.025]
[18,20100000,20150000,2.131,2.131,"ENSOARG00000011578","TICRR"]
[18,20500000,20550000,2.414,2.414]
[18,20800000,20850000,2.013,2.013,"ENSOARG00000012325,ENSOARG00000012267,ENSOARG00000012575,ENSOARG00000012506,ENSOARG00000012410","RCCD1,PRC1,MAN2A2,HDDC3,UNC45A"]
[18,23250000,23300000,-2.306,2.306,"ENSOARG00000014330","ADAMTSL3"]
[18,29200000,29250000,2.06,2.06,"ENSOARG00000000224","OTUD7A"]
[18,29250000,29300000,2.079,2.079,"ENSOARG00000000224","OTUD7A"]
[18,32400000,32450000,-2.574,2.574,"ENSOARG00000017499,ENSOARG00000002658,ENSOARG00000002566,ENSOARG00000002552","ENSOARG00000017499,C15orf39,ENSOARG00000002566,ENSOARG00000002552"]
[18,32450000,32500000,-2.15,2.15,"ENSOARG00000002658","C15orf39"]
[18,68150000,68200000,-2.354,2.354,"ENSOARG00000008354","ENSOARG00000008354"]
[19,13150000,13200000,2.186,2.186,"ENSOARG00000002706","ENTPD3"]
[19,49200000,49250000,2.511,2.511,"ENSOARG00000014150,ENSOARG00000007546","ENSOARG00000014150,VPRBP"]
[20,7850000,7900000,2.131,2.131,"ENSOARG00000010180","ITPR3"]
[20,47650000,47700000,2.131,2.131]
[21,44100000,44150000,2.542,2.542,"ENSOARG00000008338,ENSOARG00000008536","C11orf80,RCE1"]
[22,26100000,26150000,2.148,2.148]
[22,26200000,26250000,2.529,2.529]
[22,39950000,40000000,2.06,2.06]
[22,41000000,41050000,2.033,2.033,"ENSOARG00000006729","TACC2"]
[22,45650000,45700000,-2.01,2.01,"ENSOARG00000013080","DOCK1"]
[23,19150000,19200000,2.048,2.048]
[23,26150000,26200000,-2.069,2.069]
[23,46450000,46500000,2.108,2.108,"ENSOARG00000003204","LOXHD1"]
[23,57800000,57850000,2.668,2.668,"ENSOARG00000005476,ENSOARG00000005525","ALPK2,MALT1"]
[24,41350000,41400000,2.185,2.185]
[25,1100000,1150000,2.531,2.531]
[25,13900000,13950000,2.1,2.1,"ENSOARG00000004086","BICC1"]
[25,27750000,27800000,-2.296,2.296,"ENSOARG00000006661,ENSOARG00000006883","ENSOARG00000006661,C10orf54"]
[25,30050000,30100000,2.168,2.168,"ENSOARG00000008628,ENSOARG00000008618","ENSOARG00000008628,ADK"]
[25,30100000,30150000,2.964,2.964,"ENSOARG00000008618","ADK"]
[26,27750000,27800000,2.356,2.356,"ENSOARG00000000349","FUT10"]
[26,27800000,27850000,2.738,2.738,"ENSOARG00000000349","FUT10"]
["X",7950000,8000000,2.03,2.03,"ENSOARG00000010664","MID1"]
["X",9350000,9400000,2.5,2.5]
["X",32850000,32900000,-2.649,2.649]
["X",33100000,33150000,2.166,{"$f":"ABS(D195)","v":2.166}]
["X",50800000,50850000,2.282,2.282,"ENSOARG00000009360","CXorf67"]
["X",53350000,53400000,-2.288,2.288,"ENSOARG00000012572,ENSOARG00000012586","ENSOARG00000012572,ZNF81"]
["X",53450000,53500000,-2.045,2.045,"ENSOARG00000012594","ZNF182"]
["X",60000000,60050000,2.146,2.146,"ENSOARG00000015926","TEX11"]
["X",65200000,65250000,-2.176,2.176]

{"sheet":"Table S8","index":7,"n_rows":13,"n_cols":7,"rows_kept":13}
["Table S8. Overlapping selected windows selected by FST and XP-EHH"]
["Chr","Bin start","Bin end","Z FST","xpEHH","Gene ID","Gene Name"]
[2,193350000,193400000,5.0956957518702,2.295,"ENSOARG00000014195,ENSOARG00000024578","TMEFF2,U6"]
[2,211250000,211300000,5.41671755181298,2.226,"ENSOARG00000019210","CPS1"]
[3,62850000,62900000,5.08828244824589,-2.922,"ENSOARG00000001290,ENSOARG00000001316","PEX13,PUS10"]
[3,194900000,194950000,5.84955438686701,2.568]
[4,78900000,78950000,5.3126397575611,-2.22]
[6,36200000,36250000,5.31419303660321,-3.963,"ENSOARG00000000530","HERC5"]
[11,34700000,34750000,5.11346856827168,3.201,"ENSOARG00000002423","DHRS7B"]
[11,44950000,45000000,6.4808983398786,2.898,"ENSOARG00000010947","NSF"]
[15,46300000,46350000,5.3398569640507,2.612,"ENSOARG00000018914,ENSOARG00000017416,ENSOARG00000017400","ENSOARG00000018914,ENSOARG00000017416,ENSOARG00000017400"]
[17,54100000,54150000,5.02961579529066,2.155,"ENSOARG00000017389","HVCN1"]
[21,44100000,44150000,6.53181317479889,2.542,"ENSOARG00000008338,ENSOARG00000008536","C11orf80,RCE1"]

{"sheet":"Table S9","index":8,"n_rows":22,"n_cols":13,"rows_kept":22}
["Table S9. Gene Ontology enrichment analysis of the 221 candidate genes with top 20 GO terms"]
["Category","Term","Count","%","PValue","Genes","List Total","Pop Hits","Pop Total","Fold Enrichment","Bonferroni","Benjamini","FDR"]
["GOTERM_BP_DIRECT","GO:0030212~hyaluronan metabolic process",3,1.68539325842696,0.00131208484297613,"ENSOARG00000001533, ENSOARG00000001064, ENSOARG00000000729",125,5,10659,51.1632,0.454788358979164,0.454788358979164,1.85230588396367]
["GOTERM_BP_DIRECT","GO:0000209~protein polyubiquitination",4,2.24719101123595,0.0152858623446914,"ENSOARG00000009505, ENSOARG00000019010, ENSOARG00000005460, ENSOARG00000007377",125,45,10659,7.57973333333333,0.999188478538947,0.971512784252356,19.6964370073117]
["GOTERM_BP_DIRECT","GO:0007626~locomotory behavior",4,2.24719101123595,0.0353642183290714,"ENSOARG00000001290, ENSOARG00000006661, ENSOARG00000020143, ENSOARG00000011195",125,62,10659,5.50141935483871,0.999999940313553,0.996091963831848,40.1134138143397]
["GOTERM_BP_DIRECT","GO:0033151~V(D)J recombination",2,1.12359550561797,0.0457340385622396,"ENSOARG00000011894, ENSOARG00000007546",125,4,10659,42.636,0.999999999595165,0.995514410813712,48.6563794072304]
["GOTERM_BP_DIRECT","GO:0097186~amelogenesis",2,1.12359550561797,0.0568395269911721,"ENSOARG00000009764, ENSOARG00000000612",125,5,10659,34.1088,0.999999999998186,0.995515555407949,56.5398689148803]
["GOTERM_BP_DIRECT","GO:0061484~hematopoietic stem cell homeostasis",2,1.12359550561797,0.0568395269911721,"ENSOARG00000007227, ENSOARG00000002952",125,5,10659,34.1088,0.999999999998186,0.995515555407949,56.5398689148803]
["GOTERM_BP_DIRECT","GO:0061077~chaperone-mediated protein folding",2,1.12359550561797,0.0678168030068548,"ENSOARG00000006966, ENSOARG00000012410",125,6,10659,28.424,0.999999999999991,0.995516699855176,63.2134772347147]
["GOTERM_BP_DIRECT","GO:0045141~meiotic telomere clustering",2,1.12359550561797,0.0678168030068548,"ENSOARG00000018002, ENSOARG00000011894",125,6,10659,28.424,0.999999999999991,0.995516699855176,63.2134772347147]
["GOTERM_BP_DIRECT","GO:0042102~positive regulation of T cell proliferation",3,1.68539325842696,0.0686697705564888,"ENSOARG00000007488, ENSOARG00000004356, ENSOARG00000007507",125,37,10659,6.91394594594594,0.999999999999994,0.990862146775405,63.6899196291284]
["GOTERM_BP_DIRECT","GO:0032092~positive regulation of protein binding",3,1.68539325842696,0.0962185959276096,"ENSOARG00000007488, ENSOARG00000019234, ENSOARG00000012888",125,45,10659,5.6848,1,0.997098240479478,76.3228534912975]
["GOTERM_BP_DIRECT","GO:0045086~positive regulation of interleukin-2 biosynthetic process",2,1.12359550561797,0.0999939564557567,"ENSOARG00000004356, ENSOARG00000008984",125,9,10659,18.9493333333333,1,0.995520132306694,77.693017128206]
["GOTERM_CC_DIRECT","GO:0045095~keratin filament",6,3.37078651685393,{"v":4.91937701890448e-05,"d":"4.92E-05"},"ENSOARG00000016824, ENSOARG00000016989, ENSOARG00000016800, ENSOARG00000016836, ENSOARG00000017049, ENSOARG00000016853",138,39,13162,14.6733556298773,0.00598381284060967,0.00598381284060967,0.0566254275643274]
["GOTERM_CC_DIRECT","GO:0042105~alpha-beta T cell receptor complex",3,1.68539325842696,1.05369522453769E-3,"ENSOARG00000008984, ENSOARG00000009172, ENSOARG00000009256",138,5,13162,57.2260869565217,0.120690722545367,0.0622850766599515,1.20649209864023]
["GOTERM_CC_DIRECT","GO:0001772~immunological synapse",3,1.68539325842696,0.0296945519616438,"ENSOARG00000004356, ENSOARG00000008199, ENSOARG00000008984",138,26,13162,11.005016722408,0.974716725393135,0.706497971462934,29.324568071722]
["GOTERM_CC_DIRECT","GO:0005730~nucleolus",11,6.17977528089887,0.0297534275649387,"ENSOARG00000014722, ENSOARG00000013337, ENSOARG00000006729, ENSOARG00000005525, ENSOARG00000007227, ENSOARG00000007546, ENSOARG00000002952, ENSOARG00000017959, ENSOARG00000012154, ENSOARG00000003669, ENSOARG00000013906",138,484,13162,2.16765480895915,0.974903203009311,0.601980294147028,29.3739275479329]
["GOTERM_CC_DIRECT","GO:0000506~glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex",2,1.12359550561797,0.0706407457236517,"ENSOARG00000000388, ENSOARG00000000447",138,7,13162,27.2505175983436,0.99986865831005,0.832628880894203,56.9793605029888]
["GOTERM_CC_DIRECT","GO:0005882~intermediate filament",3,1.68539325842696,0.0890050035380221,"ENSOARG00000016784, ENSOARG00000016666, ENSOARG00000016036",138,48,13162,5.96105072463768,0.999988493294891,0.849746303959936,65.8114581593311]
["GOTERM_CC_DIRECT","GO:0005829~cytosol",12,6.74157303370786,0.0900130025648441,"ENSOARG00000005525, ENSOARG00000008618, ENSOARG00000015007, ENSOARG00000013994, ENSOARG00000010840, ENSOARG00000006966, ENSOARG00000010464, ENSOARG00000012072, ENSOARG00000020571, ENSOARG00000010806, ENSOARG00000000869, ENSOARG00000009972",138,670,13162,1.70824140168721,0.999989947066836,0.806784560178252,66.2444839862643]
["GOTERM_MF_DIRECT","GO:0005198~structural molecule activity",9,5.05617977528089,{"v":8.89845291644559e-05,"d":"8.90E-05"},"ENSOARG00000016824, ENSOARG00000016989, ENSOARG00000016800, ENSOARG00000016836, ENSOARG00000017049, ENSOARG00000016784, ENSOARG00000016666, ENSOARG00000016036, ENSOARG00000016853",119,127,10488,6.24574869317805,0.0110619230165004,0.0110619230165004,0.102854376151673]
["GOTERM_MF_DIRECT","GO:0005096~GTPase activator activity",5,2.80898876404494,0.0462632816416441,"ENSOARG00000005192, ENSOARG00000008903, ENSOARG00000011406, ENSOARG00000013080, ENSOARG00000009999",119,120,10488,3.67226890756302,0.997317356991537,0.948205762787134,42.1759038806357]

{"sheet":"Table S10","index":9,"n_rows":22,"n_cols":13,"rows_kept":22}
["Table S10. Ranking of KEGG pathway with top 20 Pvalue enriched from 221 genes"]
["Category","Term","Count","%","PValue","Genes","List Total","Pop Hits","Pop Total","Fold Enrichment","Bonferroni","Benjamini","FDR"]
["KEGG_PATHWAY","oas04660:T cell receptor signaling pathway",8,4.49438202247191,{"v":1.34967129095829E-5,"d":"1.35E-05"},"ENSOARG00000004356, ENSOARG00000008984, ENSOARG00000005525, ENSOARG00000009172, ENSOARG00000009256, ENSOARG00000020143, ENSOARG00000009999, ENSOARG00000010396",63,100,7729,9.81460317460317,0.00199553326136958,0.00199553326136958,0.0160786983604332]
["KEGG_PATHWAY","oas05142:Chagas disease (American trypanosomiasis)",5,2.80898876404494,0.0129896931026065,"ENSOARG00000020162, ENSOARG00000008984, ENSOARG00000009172, ENSOARG00000009256, ENSOARG00000009999",63,114,7729,5.38081314397103,0.855585833126595,0.619981359834277,14.424584909011]
["KEGG_PATHWAY","oas04115:p53 signaling pathway",4,2.24719101123595,0.0212880899762683,"ENSOARG00000016927, ENSOARG00000011894, ENSOARG00000005460, ENSOARG00000000612",63,74,7729,6.63148863148863,0.958607538769946,0.654081530926787,22.6139176700333]
["KEGG_PATHWAY","oas04120:Ubiquitin mediated proteolysis",5,2.80898876404494,0.0274031724077443,"ENSOARG00000016927, ENSOARG00000009505, ENSOARG00000010664, ENSOARG00000005460, ENSOARG00000007377",63,143,7729,4.28959928959928,0.983629512928771,0.642302915536437,28.1820733189453]
["KEGG_PATHWAY","oas04064:NF-kappa B signaling pathway",4,2.24719101123595,0.0362701022523435,"ENSOARG00000004356, ENSOARG00000011894, ENSOARG00000005525, ENSOARG00000010396",63,91,7729,5.39263910692482,0.995779254375064,0.664974521770847,35.6060551372509]
["KEGG_PATHWAY","oas05166:HTLV-I infection",6,3.37078651685393,0.0722581956488557,"ENSOARG00000011894, ENSOARG00000008984, ENSOARG00000009172, ENSOARG00000009256, ENSOARG00000009999, ENSOARG00000010396",63,279,7729,2.63833418672128,0.999984891730587,0.842769865196405,59.0806029038237]
["KEGG_PATHWAY","oas04810:Regulation of actin cytoskeleton",5,2.80898876404494,0.0862366116774824,"ENSOARG00000009764, ENSOARG00000020443, ENSOARG00000017329, ENSOARG00000013080, ENSOARG00000020143",63,209,7729,2.93498898762056,0.999998402666948,0.851435980949674,65.8511351851189]
["KEGG_PATHWAY","oas05162:Measles",4,2.24719101123595,0.0938083370314268,"ENSOARG00000008984, ENSOARG00000009172, ENSOARG00000009256, ENSOARG00000002952",63,135,7729,3.63503821281599,0.999999533803269,0.838351695805573,69.0740514763868]
["KEGG_PATHWAY","oas04662:B cell receptor signaling pathway",3,1.68539325842696,0.0980192062681611,"ENSOARG00000004356, ENSOARG00000005525, ENSOARG00000009999",63,66,7729,5.57647907647907,0.999999766009124,0.816665446679064,70.7433988503709]
["KEGG_PATHWAY","oas04721:Synaptic vesicle cycle",3,1.68539325842696,0.100531675979785,"ENSOARG00000010947, ENSOARG00000001896, ENSOARG00000012072",63,67,7729,5.49324804548685,0.999999845150678,0.791555264695284,71.6996929367477]
["KEGG_PATHWAY","oas04912:GnRH signaling pathway",3,1.68539325842696,0.151231557633828,"ENSOARG00000010180, ENSOARG00000020162, ENSOARG00000009999",63,86,7729,4.27962347729789,0.999999999971106,0.889873616806247,85.8224838521366]
["KEGG_PATHWAY","oas04640:Hematopoietic cell lineage",3,1.68539325842696,0.156835763267688,"ENSOARG00000008984, ENSOARG00000009172, ENSOARG00000009256",63,88,7729,4.1823593073593,0.99999999998916,0.8780307963635,86.8984332325956]
["KEGG_PATHWAY","oas04713:Circadian entrainment",3,1.68539325842696,0.162479854722052,"ENSOARG00000010180, ENSOARG00000020162, ENSOARG00000012286",63,90,7729,4.08941798941798,0.999999999995988,0.867159446476779,87.9059621287236]
["KEGG_PATHWAY","oas00230:Purine metabolism",4,2.24719101123595,0.174995581840614,"ENSOARG00000002706, ENSOARG00000008618, ENSOARG00000012286, ENSOARG00000012506",63,180,7729,2.72627865961199,0.999999999999567,0.869135011422273,89.8919748514249]
["KEGG_PATHWAY","oas05164:Influenza A",4,2.24719101123595,0.187041858298149,"ENSOARG00000020139, ENSOARG00000002952, ENSOARG00000017959, ENSOARG00000009999",63,186,7729,2.63833418672128,0.999999999999951,0.870379779157617,91.5168119519037]
["KEGG_PATHWAY","oas04915:Estrogen signaling pathway",3,1.68539325842696,0.18830265810631,"ENSOARG00000010180, ENSOARG00000020162, ENSOARG00000009999",63,99,7729,3.71765271765271,0.999999999999961,0.854823726360739,91.6722365399817]
["KEGG_PATHWAY","oas04070:Phosphatidylinositol signaling system",3,1.68539325842696,0.194120768909615,"ENSOARG00000010180, ENSOARG00000020162, ENSOARG00000009749",63,101,7729,3.64403583215464,0.999999999999986,0.847244333884604,92.3562342622104]
["KEGG_PATHWAY","oas04725:Cholinergic synapse",3,1.68539325842696,0.211710043351927,"ENSOARG00000010180, ENSOARG00000020162, ENSOARG00000011195",63,107,7729,3.43969737427681,0.999999999999999,0.858573993247076,94.1234197903511]
["KEGG_PATHWAY","oas04510:Focal adhesion",4,2.24719101123595,0.239310292171309,"ENSOARG00000009764, ENSOARG00000013080, ENSOARG00000020143, ENSOARG00000009999",63,211,7729,2.32573534943203,1,0.88124025373597,96.1566004250089]
["KEGG_PATHWAY","oas05340:Primary immunodeficiency",2,1.12359550561797,0.239992901350028,"ENSOARG00000008984, ENSOARG00000009172",63,34,7729,7.21661998132586,1,0.868764720511946,96.1974897006465]

{"sheet":"Table S11","index":10,"n_rows":19,"n_cols":20,"rows_kept":19}
["Table S11. Mutations in exons of KDM4B gene."]
["Gene Name","Gene ID","Mutation type","Transcript ID","Mutation","Chr","position","Reference allele","Alternative allele","Fst","P1","P2","P3","P4","P5","M1","M2","M3","M4","M5"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon1:c.T93C:p.Y31Y","chr5",16765965,"A","G",0.78125,"1/1:147,21,0:7:0:16","1/1:106,12,0:4:0:8","0/1:118,0,49:7:4:54","0/1:84,0,51:5:0:56","1/1:53,6,0:2:0:4","0/0:0,21,186:7:0:20","0/0:0,18,174:6:0:17","0/0:0,18,159:6:0:17","0/0:0,6,66:2:0:6","0/0:0,9,97:3:0:9"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon5:c.C555T:p.A185A","chr5",16757840,"G","A",0.78125,"0/0:0,15,122:5:0:11","0/0:0,12,92:4:0:8","0/1:14,0,111:5:0:19","0/1:61,0,6:3:0:8","0/0:0,21,179:7:0:16","1/1:167,18,0:6:0:17","1/1:243,33,0:11:0:32","1/1:89,9,0:3:0:8","1/1:179,21,0:7:0:20","1/1:51,6,0:2:0:6"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon6:c.C669T:p.I223I","chr5",16738397,"G","A",0.3145161,"1/1:154,21,0:7:0:18","1/1:129,12,0:4:0:10","0/1:84,0,105:7:0:87","0/1:0,3,38:1:0:3","1/1:157,21,0:7:0:18","1/1:92,9,0:3:0:7","0/0:0,24,210:8:0:21","0/1:50,0,90:5:0:53","0/0:0,27,231:9:0:24","0/0:0,15,137:5:0:12"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon6:c.G663A:p.L221L","chr5",16738403,"C","T",0.3145161,"1/1:157,21,0:7:0:18","1/1:132,12,0:4:0:10","0/1:89,0,113:8:0:92","0/1:0,3,38:1:0:3","1/1:140,18,0:6:0:15","1/1:91,9,0:3:0:7","0/0:0,27,222:9:0:24","0/1:43,0,56:4:0:46","0/0:0,27,236:9:0:24","0/0:0,18,182:6:0:15"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon11:c.C1251T:p.P417P","chr5",16704339,"G","A",0,"0/0:0,3,38:1:0:13","0/0:0,24,197:8:0:33","0/0:0,12,121:4:0:21","0/0:0,9,95:3:0:18","0/1:72,0,45:5:0:58","0/0:0,15,164:5:0:24","0/0:0,12,117:4:0:21","0/0:0,15,148:5:0:24","0/0:0,12,132:4:0:21","0/0:0,24,194:8:0:33"]
["KDM4B","ENSOARG00000008388","nonsynonymous SNV","ENSOART00000009136","exon12:c.A1708G:p.S570G","chr5",16697941,"T","C",0.1071429,"0/0:0,6,62:2:0:7","0/0:0,12,131:4:0:13","0/0:0,12,126:4:0:13","0/1:41,0,94:6:3:41","0/0:0,6,63:2:0:7","0/1:66,0,73:6:0:65","0/1:62,6,0:2:0:3","0/0:0,3,37:1:0:5","0/0:0,6,74:2:0:7","1/1:178,18,0:6:0:12"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon12:c.C1563T:p.P521P","chr5",16698086,"G","A",0.2741935,"0/1:0,0,0:0:0:3","0/0:0,6,66:2:0:4","0/0:0,15,146:5:0:12","1/1:48,6,0:2:0:5","0/0:0,12,132:4:0:9","1/1:38,3,0:1:0:3","1/1:109,12,0:4:0:10","0/0:0,6,66:2:0:4","1/1:67,6,0:2:0:5","1/1:122,15,0:5:0:13"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon12:c.G1539A:p.A513A","chr5",16698110,"C","T",0.1517857,"0/0:0,3,38:1:0:4","0/0:0,3,38:1:0:4","0/0:0,15,145:5:0:14","1/1:53,6,0:2:0:4","0/0:0,12,132:4:0:11","0/1:0,0,0:0:0:3","0/1:35,3,0:1:0:4","0/0:0,6,51:2:0:6","1/1:67,6,0:2:0:4","1/1:130,15,0:5:0:11"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon12:c.T1749C:p.H583H","chr5",16697900,"A","G",0.2,"0/0:0,3,26:1:0:5","0/0:0,3,38:1:0:5","0/0:0,12,124:4:0:12","0/1:55,0,30:4:5:36","0/0:0,6,65:2:0:7","0/1:29,0,61:3:0:29","1/1:48,6,0:2:0:3","0/0:0,3,37:1:0:5","0/0:0,3,37:1:0:5","1/1:182,18,0:6:0:13"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon14:c.A2073G:p.A691A","chr5",16696753,"T","C",0.1071429,"0/0:0,15,156:5:0:16","0/0:0,33,255:11:0:34","0/0:0,21,171:7:0:22","0/1:26,0,93:4:0:25","0/0:0,21,191:7:0:22","0/1:20,0,135:6:0:19","1/1:159,15,0:5:0:9","0/0:0,21,197:7:0:22","0/1:67,6,0:2:0:3","0/0:0,0,0:0:0:3"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon14:c.T2070C:p.N690N","chr5",16696756,"A","G",0.1071429,"0/0:0,15,153:5:0:16","0/0:0,33,255:11:0:34","0/0:0,18,167:6:0:19","0/1:26,0,94:4:0:25","0/0:0,21,191:7:0:22","0/1:20,0,135:6:0:19","1/1:147,15,0:5:0:9","0/0:0,24,215:8:0:25","0/1:67,6,0:2:0:3","0/0:0,0,0:0:0:3"]
["KDM4B","ENSOARG00000008388","frameshift deletion","ENSOART00000009136","exon15:c.2256_2257del:p.S752fs","chr5",16694410,"TTCTCCCCGGTTTGTCTCCCCG","TTCTCCCCG",0,"1/1:126,15,0:5:0:34","1/1:82,9,0:3:0:28","1/1:106,12,0:4:0:31","1/1:58,6,0:2:0:25","1/1:82,9,0:3:0:28","1/1:97,9,0:3:0:28","1/1:157,21,0:7:0:40","1/1:82,9,0:3:0:28","1/1:116,12,0:4:0:31","1/1:88,12,0:4:0:31"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon16:c.C2352T:p.H784H","chr5",16694322,"G","A",0.3534483,"0/0:0,18,173:6:0:18","0/0:0,21,196:7:0:21","0/0:0,24,200:8:0:24","0/1:50,0,29:3:0:35","0/0:0,12,137:4:0:12","0/1:127,0,122:10:0:99","1/1:161,21,0:7:0:15","0/0:0,27,237:9:0:27","0/1:116,0,56:7:4:62","1/1:161,15,0:5:0:10"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon20:c.C2757T:p.C919C","chr5",16688457,"G","A",0.3534483,"0/0:0,21,188:7:0:21","0/0:0,12,88:4:0:12","0/0:0,9,86:3:0:9","0/1:85,0,91:7:3:85","0/0:0,6,68:2:0:7","0/1:102,0,11:6:0:17","1/1:135,15,0:5:0:10","0/0:0,30,230:10:0:30","0/1:78,0,25:4:0:31","1/1:53,6,0:2:0:3"]
["KDM4B","ENSOARG00000008388","nonsynonymous SNV","ENSOART00000009136","exon20:c.C2771T:p.S924L","chr5",16688443,"G","A",0,"0/0:0,18,146:6:0:30","0/0:0,18,128:6:0:30","0/0:0,15,152:5:0:27","0/0:0,21,174:7:0:33","0/0:0,6,58:2:0:18","0/1:41,0,114:7:0:29","0/0:0,15,149:5:0:27","0/0:0,27,227:9:0:39","0/0:0,12,116:4:0:24","0/0:0,6,53:2:0:18"]
["KDM4B","ENSOARG00000008388","synonymous SNV","ENSOART00000009136","exon21:c.G2937A:p.P979P","chr5",16688200,"C","T",-0.0576923,"0/0:0,12,109:4:0:16","0/0:0,15,158:5:0:19","0/1:95,0,25:4:0:35","0/0:0,12,132:4:0:16","0/0:0,6,70:2:0:11","0/0:0,21,209:7:0:25","0/0:0,15,152:5:0:19","0/1:84,0,110:7:3:80","0/1:25,0,93:4:0:21","0/0:0,6,74:2:0:11"]
["KDM4B","ENSOARG00000008388","nonsynonymous SNV","ENSOART00000009136","exon21:c.T2806G:p.S936A","chr5",16688331,"A","C",0.45,"1/1:233,27,0:9:0:27","1/1:130,12,0:4:0:12","1/1:185,21,0:7:0:21","1/1:0,0,0:0:0:3","1/1:94,12,0:4:0:12","0/1:121,0,36:7:8:36","0/0:0,18,165:6:0:12","1/1:104,9,0:3:0:10","0/1:23,0,23:2:0:22","0/1:0,6,74:2:0:3"]