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{"sheet":"TableS1","index":0,"n_rows":85,"n_cols":6,"rows_kept":85,"merged":[[0,0,1,5]]}
["TableS1. The detailed information  of the instrumental variables in lipoprotein(a) as exposure."]
[]
["SNP","EA","OA","Beta","SE","Pval"]
["rs114165349","C","G",-0.0265647,0.00701174,{"v":1e-9,"d":"1.00E-09"}]
["rs11591147","T","G",-0.0446779,0.00820706,{"v":6.8e-16,"d":"6.80E-16"}]
["rs599839","A","G",0.0188052,0.00252655,{"v":2.8e-29,"d":"2.80E-29"}]
["rs165316","G","A",-0.0095048,0.00266554,{"v":3e-8,"d":"3.00E-08"}]
["rs1367117","A","G",0.0142927,0.00226809,{"v":1.7e-23,"d":"1.70E-23"}]
["rs1047891","A","C",-0.0200696,0.00233678,{"v":2.8e-32,"d":"2.80E-32"}]
["rs78266901","A","G",-0.0338749,0.00795593,{"v":2.4e-10,"d":"2.40E-10"}]
["rs645040","T","G",-0.0177288,0.00253324,{"v":3.2e-24,"d":"3.20E-24"}]
["rs2241894","C","T",0.0121228,0.00256032,{"v":9.5e-11,"d":"9.50E-11"}]
["rs442177","T","G",-0.00843871,0.00216294,{"v":1.1e-8,"d":"1.10E-08"}]
["rs112376176","T","C",-0.197617,0.00431367,{"v":1e-200,"d":"1.00E-200"}]
["rs2066105","T","C",0.023232,0.00237757,{"v":7.6e-24,"d":"7.60E-24"}]
["rs139389770","G","T",0.171715,0.00862131,{"v":1.1e-92,"d":"1.10E-92"}]
["rs73021251","A","G",0.0288376,0.00283225,{"v":9.1e-25,"d":"9.10E-25"}]
["rs80145669","A","G",0.154429,0.00490257,{"v":1e-200,"d":"1.00E-200"}]
["rs9456577","C","A",0.208762,0.00538773,{"v":1e-200,"d":"1.00E-200"}]
["rs9458105","A","G",-0.0796214,0.00981813,{"v":1.8e-17,"d":"1.80E-17"}]
["rs60227172","C","T",-0.0364368,0.00487641,{"v":2.6e-14,"d":"2.60E-14"}]
["rs12207188","T","C",0.190963,0.0036124,{"v":1e-200,"d":"1.00E-200"}]
["rs117901488","T","C",0.164678,0.00407514,{"v":1e-200,"d":"1.00E-200"}]
["rs116919782","A","C",0.119022,0.0108654,{"v":1.4e-28,"d":"1.40E-28"}]
["rs118133674","A","G",0.284518,0.00607062,{"v":1e-200,"d":"1.00E-200"}]
["rs34498812","A","G",-0.172389,0.00553846,{"v":1e-200,"d":"1.00E-200"}]
["rs75108267","T","C",-0.101154,0.00626653,{"v":5e-63,"d":"5.00E-63"}]
["rs3734462","A","G",0.0463093,0.00223506,{"v":1.5e-98,"d":"1.50E-98"}]
["rs4709242","T","C",0.0134082,0.00195949,{"v":1.2e-12,"d":"1.20E-12"}]
["rs79060306","T","C",-0.0282529,0.00424343,{"v":1.9e-12,"d":"1.90E-12"}]
["rs74626027","A","T",0.0211336,0.0032303,{"v":3e-11,"d":"3.00E-11"}]
["rs116926922","T","G",0.0820541,0.00444376,{"v":1.7e-75,"d":"1.70E-75"}]
["rs2634659","C","T",-0.0833213,0.00199247,{"v":1e-200,"d":"1.00E-200"}]
["rs112092923","G","A",0.204214,0.00722897,{"v":2.3e-188,"d":"2.30E-188"}]
["rs3757020","T","C",-0.0916058,0.00535462,{"v":1.6e-71,"d":"1.60E-71"}]
["rs9457843","T","C",-0.0537606,0.00273495,{"v":9.2e-88,"d":"9.20E-88"}]
["rs75786741","T","C",-0.0610016,0.00536342,{"v":3.1e-32,"d":"3.10E-32"}]
["rs7743711","G","A",-0.020701,0.00300659,{"v":1.7e-10,"d":"1.70E-10"}]
["rs12190141","G","A",0.0399129,0.00561401,{"v":3.1e-12,"d":"3.10E-12"}]
["rs4646272","G","T",0.227738,0.00396311,{"v":1e-200,"d":"1.00E-200"}]
["rs8187724","C","A",-0.203662,0.00643907,{"v":1e-200,"d":"1.00E-200"}]
["rs9458011","T","C",-0.113229,0.0036055,{"v":1e-200,"d":"1.00E-200"}]
["rs783143","G","A",-0.213242,0.00557822,{"v":1e-200,"d":"1.00E-200"}]
["rs11961006","G","A",-0.0635571,0.00205125,{"v":1e-200,"d":"1.00E-200"}]
["rs62637702","C","T",0.0843401,0.00737969,{"v":6.4e-34,"d":"6.40E-34"}]
["rs17649505","T","C",-0.0159625,0.00206388,{"v":4e-16,"d":"4.00E-16"}]
["rs1121035","T","G",0.04159,0.00618361,{"v":2.5e-11,"d":"2.50E-11"}]
["rs41267807","C","T",-0.292071,0.00719744,{"v":1e-200,"d":"1.00E-200"}]
["rs75534358","A","G",-0.0448775,0.00436335,{"v":9.2e-29,"d":"9.20E-29"}]
["rs77632648","G","C",-0.0580808,0.00445134,{"v":9.2e-43,"d":"9.20E-43"}]
["rs41267809","G","A",-0.281138,0.00682365,{"v":1e-200,"d":"1.00E-200"}]
["rs112476023","T","G",-0.129186,0.00956133,{"v":7.4e-45,"d":"7.40E-45"}]
["rs34059508","A","G",-0.0407262,0.00536974,{"v":1.1e-13,"d":"1.10E-13"}]
["rs624249","A","C",-0.0892803,0.00180369,{"v":1e-200,"d":"1.00E-200"}]
["rs3812316","G","C",-0.0135659,0.00318706,{"v":2.7e-11,"d":"2.70E-11"}]
["rs4719841","G","A",-0.0109877,0.0021611,{"v":2.9e-14,"d":"2.90E-14"}]
["rs9987289","G","A",0.018849,0.00392143,{"v":6.6e-12,"d":"6.60E-12"}]
["rs328","G","C",0.0229532,0.00352732,{"v":6.1e-19,"d":"6.10E-19"}]
["rs61887548","C","T",-0.0310492,0.00679299,{"v":7.4e-11,"d":"7.40E-11"}]
["rs17135399","G","A",0.0194215,0.00440323,{"v":4.1e-9,"d":"4.10E-09"}]
["rs2657879","G","A",-0.0112951,0.00275864,{"v":2.1e-10,"d":"2.10E-10"}]
["rs1532085","G","A",-0.00929301,0.00218702,{"v":5.7e-9,"d":"5.70E-09"}]
["rs55707100","T","C",-0.0499694,0.00676392,{"v":5.7e-29,"d":"5.70E-29"}]
["rs11350","C","T",0.0189314,0.00341757,{"v":4.8e-13,"d":"4.80E-13"}]
["rs247617","A","C",-0.0262774,0.00227681,{"v":1.2e-50,"d":"1.20E-50"}]
["rs17666927","A","G",-0.0273926,0.00723215,{"v":1e-9,"d":"1.00E-09"}]
["rs2000999","A","G",0.0149412,0.00290517,{"v":2.3e-14,"d":"2.30E-14"}]
["rs4646352","T","C",-0.0103537,0.00213648,{"v":1.6e-12,"d":"1.60E-12"}]
["rs77542162","G","A",0.0351547,0.0072666,{"v":1.6e-20,"d":"1.60E-20"}]
["rs1801689","C","A",0.0688934,0.00622024,{"v":9.7e-64,"d":"9.70E-64"}]
["rs2277998","A","G",0.0112071,0.0023636,{"v":1.9e-8,"d":"1.90E-08"}]
["rs55791371","C","A",-0.0210536,0.00329605,{"v":5.2e-21,"d":"5.20E-21"}]
["rs1132899","C","T",-0.0110369,0.00219379,{"v":9.3e-18,"d":"9.30E-18"}]
["rs35866622","T","C",0.0127031,0.00217095,{"v":4.5e-18,"d":"4.50E-18"}]
["rs1064725","G","T",0.0253902,0.0058702,{"v":1.9e-8,"d":"1.90E-08"}]
["rs7412","T","C",-0.138567,0.00395952,{"v":1e-200,"d":"1.00E-200"}]
["rs2722736","C","T",-0.0120098,0.002863,{"v":1.4e-9,"d":"1.40E-09"}]
["rs641738","T","C",0.00956368,0.00217058,{"v":1.4e-11,"d":"1.40E-11"}]
["rs73572039","T","C",0.0201013,0.00349451,{"v":8.2e-14,"d":"8.20E-14"}]
["rs2965157","C","T",-0.0526385,0.00632022,{"v":2.4e-34,"d":"2.40E-34"}]
["rs2207132","A","G",0.0244091,0.0059347,{"v":2.5e-9,"d":"2.50E-09"}]
["rs73078112","T","C",0.0297122,0.006662,{"v":8.3e-10,"d":"8.30E-10"}]
["rs2427530","A","G",0.00813001,0.00247492,{"v":2.4e-9,"d":"2.40E-09"}]
["rs1800961","T","C",-0.0215691,0.00627631,{"v":7.7e-10,"d":"7.70E-10"}]
["rs2183573","G","A",0.0105766,0.00217154,{"v":2.1e-8,"d":"2.10E-08"}]

{"sheet":"TableS2","index":1,"n_rows":327,"n_cols":8,"rows_kept":327,"merged":[[0,0,1,7]]}
["Table S2. The detailed information of the instrumental variables in lipoprotein(a) as exposure and each IMID trait as outcome."]
[]
["Traits (outcome)","SNP","EA","OA","Beta","SE","Pval","F"]
["Celiac disease","rs1367117","A","G",0.0142927,0.00226809,{"v":1.7e-23,"d":"1.70E-23"},39.71051308]
[null,"rs1532085","G","A",-0.00929301,0.00218702,{"v":5.7e-9,"d":"5.70E-09"},18.05530418]
[null,"rs2000999","A","G",0.0149412,0.00290517,{"v":2.3e-14,"d":"2.30E-14"},26.44998113]
[null,"rs41267807","C","T",-0.292071,0.00719744,{"v":1e-200,"d":"1.00E-200"},1646.714383]
["Crohn's disease","rs11591147","T","G",-0.0446779,0.00820706,{"v":6.8e-16,"d":"6.80E-16"},29.63519548]
[null,"rs1367117","A","G",0.0142927,0.00226809,{"v":1.7e-23,"d":"1.70E-23"},39.71051308]
[null,"rs1532085","G","A",-0.00929301,0.00218702,{"v":5.7e-9,"d":"5.70E-09"},18.05530418]
[null,"rs2000999","A","G",0.0149412,0.00290517,{"v":2.3e-14,"d":"2.30E-14"},26.44998113]
[null,"rs2965157","C","T",-0.0526385,0.00632022,{"v":2.4e-34,"d":"2.40E-34"},69.36495807]
[null,"rs35866622","T","C",0.0127031,0.00217095,{"v":4.5e-18,"d":"4.50E-18"},34.23870273]
[null,"rs41267807","C","T",-0.292071,0.00719744,{"v":1e-200,"d":"1.00E-200"},1646.714383]
[null,"rs599839","A","G",0.0188052,0.00252655,{"v":2.8e-29,"d":"2.80E-29"},55.3984519]
["Inflammatory bowel disease","rs11591147","T","G",-0.0446779,0.00820706,{"v":6.8e-16,"d":"6.80E-16"},29.63519548]
[null,"rs1367117","A","G",0.0142927,0.00226809,{"v":1.7e-23,"d":"1.70E-23"},39.71051308]
[null,"rs1532085","G","A",-0.00929301,0.00218702,{"v":5.7e-9,"d":"5.70E-09"},18.05530418]
[null,"rs2000999","A","G",0.0149412,0.00290517,{"v":2.3e-14,"d":"2.30E-14"},26.44998113]
[null,"rs2965157","C","T",-0.0526385,0.00632022,{"v":2.4e-34,"d":"2.40E-34"},69.36495807]
[null,"rs41267807","C","T",-0.292071,0.00719744,{"v":1e-200,"d":"1.00E-200"},1646.714383]
[null,"rs599839","A","G",0.0188052,0.00252655,{"v":2.8e-29,"d":"2.80E-29"},55.3984519]
["Multiple sclerosis","rs1047891","A","C",-0.0200696,0.00233678,{"v":2.8e-32,"d":"2.80E-32"},73.76312195]
[null,"rs1064725","G","T",0.0253902,0.0058702,{"v":1.9e-8,"d":"1.90E-08"},18.70785337]
[null,"rs1121035","T","G",0.04159,0.00618361,{"v":2.5e-11,"d":"2.50E-11"},45.23672636]
[null,"rs1132899","C","T",-0.0110369,0.00219379,{"v":9.3e-18,"d":"9.30E-18"},25.31055219]
[null,"rs11350","C","T",0.0189314,0.00341757,{"v":4.8e-13,"d":"4.80E-13"},30.68514189]
[null,"rs11591147","T","G",-0.0446779,0.00820706,{"v":6.8e-16,"d":"6.80E-16"},29.63519548]
[null,"rs11961006","G","A",-0.0635571,0.00205125,{"v":1e-200,"d":"1.00E-200"},960.0380971]
[null,"rs12190141","G","A",0.0399129,0.00561401,{"v":3.1e-12,"d":"3.10E-12"},50.54494334]
[null,"rs12207188","T","C",0.190963,0.0036124,{"v":1e-200,"d":"1.00E-200"},2794.501198]
[null,"rs1367117","A","G",0.0142927,0.00226809,{"v":1.7e-23,"d":"1.70E-23"},39.71051308]
[null,"rs165316","G","A",-0.0095048,0.00266554,{"v":3e-8,"d":"3.00E-08"},12.71490347]
[null,"rs17135399","G","A",0.0194215,0.00440323,{"v":4.1e-9,"d":"4.10E-09"},19.45451041]
[null,"rs17649505","T","C",-0.0159625,0.00206388,{"v":4e-16,"d":"4.00E-16"},59.81780123]
[null,"rs17666927","A","G",-0.0273926,0.00723215,{"v":1e-9,"d":"1.00E-09"},14.34594532]
[null,"rs1801689","C","A",0.0688934,0.00622024,{"v":9.7e-64,"d":"9.70E-64"},122.6700277]
[null,"rs2000999","A","G",0.0149412,0.00290517,{"v":2.3e-14,"d":"2.30E-14"},26.44998113]
[null,"rs2066105","T","C",0.023232,0.00237757,{"v":7.6e-24,"d":"7.60E-24"},95.47816934]
[null,"rs2183573","G","A",0.0105766,0.00217154,{"v":2.1e-8,"d":"2.10E-08"},23.72214754]
[null,"rs2207132","A","G",0.0244091,0.0059347,{"v":2.5e-9,"d":"2.50E-09"},16.91622694]
[null,"rs2241894","C","T",0.0121228,0.00256032,{"v":9.5e-11,"d":"9.50E-11"},22.41893062]
[null,"rs2277998","A","G",0.0112071,0.0023636,{"v":1.9e-8,"d":"1.90E-08"},22.48205684]
[null,"rs247617","A","C",-0.0262774,0.00227681,{"v":1.2e-50,"d":"1.20E-50"},133.2013767]
[null,"rs2634659","C","T",-0.0833213,0.00199247,{"v":1e-200,"d":"1.00E-200"},1748.743053]
[null,"rs2657879","G","A",-0.0112951,0.00275864,{"v":2.1e-10,"d":"2.10E-10"},16.76438446]
[null,"rs2722736","C","T",-0.0120098,0.002863,{"v":1.4e-9,"d":"1.40E-09"},17.59650284]
[null,"rs2965157","C","T",-0.0526385,0.00632022,{"v":2.4e-34,"d":"2.40E-34"},69.36495807]
[null,"rs34059508","A","G",-0.0407262,0.00536974,{"v":1.1e-13,"d":"1.10E-13"},57.52263518]
[null,"rs34498812","A","G",-0.172389,0.00553846,{"v":1e-200,"d":"1.00E-200"},968.8098901]
[null,"rs3734462","A","G",0.0463093,0.00223506,{"v":1.5e-98,"d":"1.50E-98"},429.2947428]
[null,"rs41267807","C","T",-0.292071,0.00719744,{"v":1e-200,"d":"1.00E-200"},1646.714383]
[null,"rs41267809","G","A",-0.281138,0.00682365,{"v":1e-200,"d":"1.00E-200"},1697.473981]
[null,"rs4646272","G","T",0.227738,0.00396311,{"v":1e-200,"d":"1.00E-200"},3302.145923]
[null,"rs4646352","T","C",-0.0103537,0.00213648,{"v":1.6e-12,"d":"1.60E-12"},23.48502358]
[null,"rs4709242","T","C",0.0134082,0.00195949,{"v":1.2e-12,"d":"1.20E-12"},46.82225929]
[null,"rs4719841","G","A",-0.0109877,0.0021611,{"v":2.9e-14,"d":"2.90E-14"},25.85004894]
[null,"rs55707100","T","C",-0.0499694,0.00676392,{"v":5.7e-29,"d":"5.70E-29"},54.57689884]
[null,"rs55791371","C","A",-0.0210536,0.00329605,{"v":5.2e-21,"d":"5.20E-21"},40.8002348]
[null,"rs599839","A","G",0.0188052,0.00252655,{"v":2.8e-29,"d":"2.80E-29"},55.3984519]
[null,"rs61887548","C","T",-0.0310492,0.00679299,{"v":7.4e-11,"d":"7.40E-11"},20.89182546]
[null,"rs624249","A","C",-0.0892803,0.00180369,{"v":1e-200,"d":"1.00E-200"},2450.106693]
[null,"rs641738","T","C",0.00956368,0.00217058,{"v":1.4e-11,"d":"1.40E-11"},19.41314901]
[null,"rs645040","T","G",-0.0177288,0.00253324,{"v":3.2e-24,"d":"3.20E-24"},48.97827862]
[null,"rs73021251","A","G",0.0288376,0.00283225,{"v":9.1e-25,"d":"9.10E-25"},103.6698729]
[null,"rs73078112","T","C",0.0297122,0.006662,{"v":8.3e-10,"d":"8.30E-10"},19.89105749]
[null,"rs73572039","T","C",0.0201013,0.00349451,{"v":8.2e-14,"d":"8.20E-14"},33.08820631]
[null,"rs7412","T","C",-0.138567,0.00395952,{"v":1e-200,"d":"1.00E-200"},1224.706596]
[null,"rs7743711","G","A",-0.020701,0.00300659,{"v":1.7e-10,"d":"1.70E-10"},47.40582874]
[null,"rs783143","G","A",-0.213242,0.00557822,{"v":1e-200,"d":"1.00E-200"},1461.341531]
[null,"rs8187724","C","A",-0.203662,0.00643907,{"v":1e-200,"d":"1.00E-200"},1000.394339]
[null,"rs9457843","T","C",-0.0537606,0.00273495,{"v":9.2e-88,"d":"9.20E-88"},386.3909464]
[null,"rs9458011","T","C",-0.113229,0.0036055,{"v":1e-200,"d":"1.00E-200"},986.2382762]
[null,"rs9458105","A","G",-0.0796214,0.00981813,{"v":1.8e-17,"d":"1.80E-17"},65.76571901]
["Psoriasis","rs1047891","A","C",-0.0200696,0.00233678,{"v":2.8e-32,"d":"2.80E-32"},73.76312195]
[null,"rs1064725","G","T",0.0253902,0.0058702,{"v":1.9e-8,"d":"1.90E-08"},18.70785337]
[null,"rs112092923","G","A",0.204214,0.00722897,{"v":2.3e-188,"d":"2.30E-188"},798.0235157]
[null,"rs1121035","T","G",0.04159,0.00618361,{"v":2.5e-11,"d":"2.50E-11"},45.23672636]
[null,"rs112376176","T","C",-0.197617,0.00431367,{"v":1e-200,"d":"1.00E-200"},2098.709255]
[null,"rs1132899","C","T",-0.0110369,0.00219379,{"v":9.3e-18,"d":"9.30E-18"},25.31055219]
[null,"rs11350","C","T",0.0189314,0.00341757,{"v":4.8e-13,"d":"4.80E-13"},30.68514189]
[null,"rs11591147","T","G",-0.0446779,0.00820706,{"v":6.8e-16,"d":"6.80E-16"},29.63519548]
[null,"rs116926922","T","G",0.0820541,0.00444376,{"v":1.7e-75,"d":"1.70E-75"},340.954865]
[null,"rs117901488","T","C",0.164678,0.00407514,{"v":1e-200,"d":"1.00E-200"},1632.990322]
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[null,"rs1064725","G","T",0.0253902,0.0058702,{"v":1.9e-8,"d":"1.90E-08"},18.70785337]
[null,"rs112092923","G","A",0.204214,0.00722897,{"v":2.3e-188,"d":"2.30E-188"},798.0235157]
[null,"rs1121035","T","G",0.04159,0.00618361,{"v":2.5e-11,"d":"2.50E-11"},45.23672636]
[null,"rs112376176","T","C",-0.197617,0.00431367,{"v":1e-200,"d":"1.00E-200"},2098.709255]
[null,"rs112476023","T","G",-0.129186,0.00956133,{"v":7.4e-45,"d":"7.40E-45"},182.5541865]
[null,"rs1132899","C","T",-0.0110369,0.00219379,{"v":9.3e-18,"d":"9.30E-18"},25.31055219]
[null,"rs11350","C","T",0.0189314,0.00341757,{"v":4.8e-13,"d":"4.80E-13"},30.68514189]
[null,"rs11591147","T","G",-0.0446779,0.00820706,{"v":6.8e-16,"d":"6.80E-16"},29.63519548]
[null,"rs116919782","A","C",0.119022,0.0108654,{"v":1.4e-28,"d":"1.40E-28"},119.9942841]
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[null,"rs1367117","A","G",0.0142927,0.00226809,{"v":1.7e-23,"d":"1.70E-23"},39.71051308]
[null,"rs139389770","G","T",0.171715,0.00862131,{"v":1.1e-92,"d":"1.10E-92"},396.7047999]
[null,"rs1532085","G","A",-0.00929301,0.00218702,{"v":5.7e-9,"d":"5.70E-09"},18.05530418]
[null,"rs165316","G","A",-0.0095048,0.00266554,{"v":3e-8,"d":"3.00E-08"},12.71490347]
[null,"rs17135399","G","A",0.0194215,0.00440323,{"v":4.1e-9,"d":"4.10E-09"},19.45451041]
[null,"rs17649505","T","C",-0.0159625,0.00206388,{"v":4e-16,"d":"4.00E-16"},59.81780123]
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[null,"rs1800961","T","C",-0.0215691,0.00627631,{"v":7.7e-10,"d":"7.70E-10"},11.81007853]
[null,"rs1801689","C","A",0.0688934,0.00622024,{"v":9.7e-64,"d":"9.70E-64"},122.6700277]
[null,"rs2000999","A","G",0.0149412,0.00290517,{"v":2.3e-14,"d":"2.30E-14"},26.44998113]
[null,"rs2066105","T","C",0.023232,0.00237757,{"v":7.6e-24,"d":"7.60E-24"},95.47816934]
[null,"rs2183573","G","A",0.0105766,0.00217154,{"v":2.1e-8,"d":"2.10E-08"},23.72214754]
[null,"rs2207132","A","G",0.0244091,0.0059347,{"v":2.5e-9,"d":"2.50E-09"},16.91622694]
[null,"rs2241894","C","T",0.0121228,0.00256032,{"v":9.5e-11,"d":"9.50E-11"},22.41893062]
[null,"rs2277998","A","G",0.0112071,0.0023636,{"v":1.9e-8,"d":"1.90E-08"},22.48205684]
[null,"rs2427530","A","G",0.00813001,0.00247492,{"v":2.4e-9,"d":"2.40E-09"},10.79089182]
[null,"rs247617","A","C",-0.0262774,0.00227681,{"v":1.2e-50,"d":"1.20E-50"},133.2013767]
[null,"rs2634659","C","T",-0.0833213,0.00199247,{"v":1e-200,"d":"1.00E-200"},1748.743053]
[null,"rs2657879","G","A",-0.0112951,0.00275864,{"v":2.1e-10,"d":"2.10E-10"},16.76438446]
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[null,"rs2965157","C","T",-0.0526385,0.00632022,{"v":2.4e-34,"d":"2.40E-34"},69.36495807]
[null,"rs34059508","A","G",-0.0407262,0.00536974,{"v":1.1e-13,"d":"1.10E-13"},57.52263518]
[null,"rs34498812","A","G",-0.172389,0.00553846,{"v":1e-200,"d":"1.00E-200"},968.8098901]
[null,"rs35866622","T","C",0.0127031,0.00217095,{"v":4.5e-18,"d":"4.50E-18"},34.23870273]
[null,"rs3734462","A","G",0.0463093,0.00223506,{"v":1.5e-98,"d":"1.50E-98"},429.2947428]
[null,"rs3757020","T","C",-0.0916058,0.00535462,{"v":1.6e-71,"d":"1.60E-71"},292.6753469]
[null,"rs41267807","C","T",-0.292071,0.00719744,{"v":1e-200,"d":"1.00E-200"},1646.714383]
[null,"rs41267809","G","A",-0.281138,0.00682365,{"v":1e-200,"d":"1.00E-200"},1697.473981]
[null,"rs442177","T","G",-0.00843871,0.00216294,{"v":1.1e-8,"d":"1.10E-08"},15.22161349]
[null,"rs4646272","G","T",0.227738,0.00396311,{"v":1e-200,"d":"1.00E-200"},3302.145923]
[null,"rs4646352","T","C",-0.0103537,0.00213648,{"v":1.6e-12,"d":"1.60E-12"},23.48502358]
[null,"rs4709242","T","C",0.0134082,0.00195949,{"v":1.2e-12,"d":"1.20E-12"},46.82225929]
[null,"rs4719841","G","A",-0.0109877,0.0021611,{"v":2.9e-14,"d":"2.90E-14"},25.85004894]
[null,"rs55707100","T","C",-0.0499694,0.00676392,{"v":5.7e-29,"d":"5.70E-29"},54.57689884]
[null,"rs55791371","C","A",-0.0210536,0.00329605,{"v":5.2e-21,"d":"5.20E-21"},40.8002348]
[null,"rs599839","A","G",0.0188052,0.00252655,{"v":2.8e-29,"d":"2.80E-29"},55.3984519]
[null,"rs60227172","C","T",-0.0364368,0.00487641,{"v":2.6e-14,"d":"2.60E-14"},55.83127439]
[null,"rs61887548","C","T",-0.0310492,0.00679299,{"v":7.4e-11,"d":"7.40E-11"},20.89182546]
[null,"rs624249","A","C",-0.0892803,0.00180369,{"v":1e-200,"d":"1.00E-200"},2450.106693]
[null,"rs62637702","C","T",0.0843401,0.00737969,{"v":6.4e-34,"d":"6.40E-34"},130.6139296]
[null,"rs641738","T","C",0.00956368,0.00217058,{"v":1.4e-11,"d":"1.40E-11"},19.41314901]
[null,"rs645040","T","G",-0.0177288,0.00253324,{"v":3.2e-24,"d":"3.20E-24"},48.97827862]
[null,"rs73021251","A","G",0.0288376,0.00283225,{"v":9.1e-25,"d":"9.10E-25"},103.6698729]
[null,"rs73078112","T","C",0.0297122,0.006662,{"v":8.3e-10,"d":"8.30E-10"},19.89105749]
[null,"rs73572039","T","C",0.0201013,0.00349451,{"v":8.2e-14,"d":"8.20E-14"},33.08820631]
[null,"rs7412","T","C",-0.138567,0.00395952,{"v":1e-200,"d":"1.00E-200"},1224.706596]
[null,"rs75108267","T","C",-0.101154,0.00626653,{"v":5e-63,"d":"5.00E-63"},260.560984]
[null,"rs75534358","A","G",-0.0448775,0.00436335,{"v":9.2e-29,"d":"9.20E-29"},105.7827175]
[null,"rs75786741","T","C",-0.0610016,0.00536342,{"v":3.1e-32,"d":"3.10E-32"},129.3589101]
[null,"rs7743711","G","A",-0.020701,0.00300659,{"v":1.7e-10,"d":"1.70E-10"},47.40582874]
[null,"rs77542162","G","A",0.0351547,0.0072666,{"v":1.6e-20,"d":"1.60E-20"},23.40463071]
[null,"rs78266901","A","G",-0.0338749,0.00795593,{"v":2.4e-10,"d":"2.40E-10"},18.12890807]
[null,"rs783143","G","A",-0.213242,0.00557822,{"v":1e-200,"d":"1.00E-200"},1461.341531]
[null,"rs79060306","T","C",-0.0282529,0.00424343,{"v":1.9e-12,"d":"1.90E-12"},44.32915875]
[null,"rs80145669","A","G",0.154429,0.00490257,{"v":1e-200,"d":"1.00E-200"},992.2191884]
[null,"rs8187724","C","A",-0.203662,0.00643907,{"v":1e-200,"d":"1.00E-200"},1000.394339]
[null,"rs9456577","C","A",0.208762,0.00538773,{"v":1e-200,"d":"1.00E-200"},1501.373551]
[null,"rs9457843","T","C",-0.0537606,0.00273495,{"v":9.2e-88,"d":"9.20E-88"},386.3909464]
[null,"rs9458011","T","C",-0.113229,0.0036055,{"v":1e-200,"d":"1.00E-200"},986.2382762]
[null,"rs9458105","A","G",-0.0796214,0.00981813,{"v":1.8e-17,"d":"1.80E-17"},65.76571901]
[null,"rs9987289","G","A",0.018849,0.00392143,{"v":6.6e-12,"d":"6.60E-12"},23.10389514]
["Ulcerative colitis","rs11591147","T","G",-0.0446779,0.00820706,{"v":6.8e-16,"d":"6.80E-16"},29.63519548]
[null,"rs1367117","A","G",0.0142927,0.00226809,{"v":1.7e-23,"d":"1.70E-23"},39.71051308]
[null,"rs1532085","G","A",-0.00929301,0.00218702,{"v":5.7e-9,"d":"5.70E-09"},18.05530418]
[null,"rs2000999","A","G",0.0149412,0.00290517,{"v":2.3e-14,"d":"2.30E-14"},26.44998113]
[null,"rs2965157","C","T",-0.0526385,0.00632022,{"v":2.4e-34,"d":"2.40E-34"},69.36495807]
[null,"rs35866622","T","C",0.0127031,0.00217095,{"v":4.5e-18,"d":"4.50E-18"},34.23870273]
[null,"rs41267807","C","T",-0.292071,0.00719744,{"v":1e-200,"d":"1.00E-200"},1646.714383]
[null,"rs599839","A","G",0.0188052,0.00252655,{"v":2.8e-29,"d":"2.80E-29"},55.3984519]

{"sheet":"TableS3","index":2,"n_rows":189,"n_cols":8,"rows_kept":189,"merged":[[0,0,1,7]]}
["Table S3. The detailed information of the instrumental variables in each IMID trait as exposure and lipoprotein(a) as outcome."]
[]
["Traits (exposure)","SNP","EA","OA","Beta","SE","Pval","F"]
["Celiac disease","rs10484565","A","G",-0.758006,0.0421817,{"v":3.41e-72,"d":"3.41E-72"},322.8950132]
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[null,"rs16894681","G","T",-0.357961,0.0647542,{"v":3.24e-8,"d":"3.24E-08"},30.55622851]
[null,"rs2267633","G","A",-0.379505,0.0300479,{"v":1.48e-36,"d":"1.48E-36"},159.5037731]
[null,"rs2394882","C","A",0.707449,0.0223311,{"v":1e-200,"d":"1.00E-200"},1003.538988]
[null,"rs6903496","A","G",0.506818,0.0552992,{"v":4.94e-20,"d":"4.94E-20"},83.99057858]
[null,"rs6930981","C","T",0.467501,0.0193903,{"v":2.02e-128,"d":"2.02E-128"},581.2463518]
[null,"rs7162232","A","G",-0.116894,0.0202624,{"v":7.97e-9,"d":"7.97E-09"},33.27874037]
[null,"rs9257745","T","C",-0.208624,0.0284152,{"v":2.1e-13,"d":"2.10E-13"},53.90031566]
[null,"rs9461799","C","T",-0.968637,0.0221453,{"v":1e-200,"d":"1.00E-200"},1913.036161]
["Crohn's disease","rs10758669","A","C",-0.14975,0.012299,{"v":4.19e-34,"d":"4.19E-34"},148.2440648]
[null,"rs10800309","G","A",-0.0904086,0.0126389,{"v":8.48e-13,"d":"8.48E-13"},51.16632068]
[null,"rs11264426","G","T",-0.0887364,0.0138532,{"v":1.5e-10,"d":"1.50E-10"},41.02859624]
[null,"rs12718244","A","G",0.0800684,0.0121633,{"v":4.62e-11,"d":"4.62E-11"},43.33139978]
[null,"rs12720356","C","A",0.143323,0.0216215,{"v":3.39e-11,"d":"3.39E-11"},43.93831476]
[null,"rs12796489","A","C",-0.79177,0.0526931,{"v":4.96e-51,"d":"4.96E-51"},225.7739553]
[null,"rs1292053","G","A",0.0911854,0.0118917,{"v":1.75e-14,"d":"1.75E-14"},58.79575638]
[null,"rs16870166","A","G",0.148763,0.0262,{"v":1.36e-8,"d":"1.36E-08"},32.23818095]
[null,"rs181826","A","C",0.0995948,0.0127047,{"v":4.53e-15,"d":"4.53E-15"},61.45083017]
[null,"rs1847472","A","C",-0.0853854,0.0132299,{"v":1.09e-10,"d":"1.09E-10"},41.65214456]
[null,"rs1990623","G","A",0.203737,0.0157939,{"v":4.52e-38,"d":"4.52E-38"},166.3965438]
[null,"rs2024092","A","G",0.147664,0.0143378,{"v":7.13e-25,"d":"7.13E-25"},106.0638718]
[null,"rs212388","T","C",-0.102377,0.0124319,{"v":1.8e-16,"d":"1.80E-16"},67.81301245]
[null,"rs2143606","G","A",-0.0742459,0.0120964,{"v":8.36e-10,"d":"8.36E-10"},37.67176156]
[null,"rs2227551","T","G",0.0994456,0.0137489,{"v":4.72e-13,"d":"4.72E-13"},52.31406815]
[null,"rs2230365","T","C",0.106798,0.0160696,{"v":3.01e-11,"d":"3.01E-11"},44.16714854]
[null,"rs2395022","C","A",-0.177152,0.0281553,{"v":3.13e-10,"d":"3.13E-10"},39.58722474]
[null,"rs2413583","T","C",-0.210407,0.0168361,{"v":7.72e-36,"d":"7.72E-36"},156.1782782]
[null,"rs2476601","G","A",0.18506,0.0219839,{"v":3.83e-17,"d":"3.83E-17"},70.85963181]
[null,"rs2641348","G","A",-0.121336,0.0198422,{"v":9.65e-10,"d":"9.65E-10"},37.39236698]
[null,"rs2836878","A","G",-0.10859,0.0138558,{"v":4.61e-15,"d":"4.61E-15"},61.41857131]
[null,"rs28999107","T","G",0.0856594,0.0126539,{"v":1.29e-11,"d":"1.29E-11"},45.82310517]
[null,"rs2945412","A","G",0.113034,0.0123195,{"v":4.51e-20,"d":"4.51E-20"},84.18123342]
[null,"rs3024505","A","G",0.165311,0.0159634,{"v":3.95e-25,"d":"3.95E-25"},107.2348551]
[null,"rs303429","T","C",0.0762756,0.0124275,{"v":8.38e-10,"d":"8.38E-10"},37.66925031]
[null,"rs3094035","T","G",-0.138692,0.021357,{"v":8.36e-11,"d":"8.36E-11"},42.17019235]
[null,"rs3130186","T","C",0.0851897,0.0143868,{"v":3.19e-9,"d":"3.19E-09"},35.06138121]
[null,"rs35320439","C","T",0.0840555,0.0137546,{"v":9.89e-10,"d":"9.89E-10"},37.3438936]
[null,"rs3812609","T","C",-0.0938357,0.0169253,{"v":2.95e-8,"d":"2.95E-08"},30.73595426]
[null,"rs4151651","A","G",0.261502,0.0314783,{"v":9.79e-17,"d":"9.79E-17"},69.00979621]
[null,"rs438475","A","G",0.159076,0.0172814,{"v":3.42e-20,"d":"3.42E-20"},84.7295177]
[null,"rs4802307","T","G",-0.0898372,0.0131707,{"v":9.04e-12,"d":"9.04E-12"},46.52409732]
[null,"rs61839660","T","C",0.148159,0.0203346,{"v":3.19e-13,"d":"3.19E-13"},53.08454068]
[null,"rs640466","C","T",-0.0758092,0.0124963,{"v":1.31e-9,"d":"1.31E-09"},36.80138786]
[null,"rs6651252","C","T",-0.149029,0.0183017,{"v":3.86e-16,"d":"3.86E-16"},66.30434143]
[null,"rs6738825","G","A",-0.0747667,0.0118565,{"v":2.86e-10,"d":"2.86E-10"},39.76368907]
[null,"rs6827756","C","T",-0.0789645,0.0125632,{"v":3.27e-10,"d":"3.27E-10"},39.50449258]
[null,"rs6908425","C","T",0.103988,0.0150464,{"v":4.81e-12,"d":"4.81E-12"},47.76221951]
[null,"rs7194886","T","C",-0.226986,0.0121749,{"v":1.42e-77,"d":"1.42E-77"},347.5766502]
[null,"rs7517847","G","T",-0.335814,0.0124758,{"v":1.38e-159,"d":"1.38E-159"},724.5094311]
[null,"rs7608910","G","A",0.120609,0.0121405,{"v":2.95e-23,"d":"2.95E-23"},98.68918038]
[null,"rs7775228","C","T",0.151327,0.0176028,{"v":8.2e-18,"d":"8.20E-18"},73.90138729]
[null,"rs9264942","C","T",0.150794,0.0128298,{"v":6.78e-32,"d":"6.78E-32"},138.1375045]
[null,"rs974801","G","A",-0.0699649,0.0122956,{"v":1.27e-8,"d":"1.27E-08"},32.37756906]
["Inflammatory bowel disease","rs10758669","A","C",-0.148762,0.0102138,{"v":4.7e-48,"d":"4.70E-48"},212.1270662]
[null,"rs10761659","G","A",0.153811,0.0100347,{"v":4.97e-53,"d":"4.97E-53"},234.9377323]
[null,"rs10800309","G","A",-0.132111,0.010405,{"v":6.15e-37,"d":"6.15E-37"},161.2057611]
[null,"rs11230563","T","C",-0.081194,0.0105845,{"v":1.71e-14,"d":"1.71E-14"},58.84288367]
[null,"rs11745587","A","G",-0.120741,0.0105268,{"v":1.87e-30,"d":"1.87E-30"},131.5538495]
[null,"rs12103","C","T",-0.0867354,0.0130755,{"v":3.28e-11,"d":"3.28E-11"},44.00103872]
[null,"rs12599586","A","G",-0.0607553,0.0110249,{"v":3.57e-8,"d":"3.57E-08"},30.36727267]
[null,"rs12718244","A","G",0.0761709,0.0100437,{"v":3.35e-14,"d":"3.35E-14"},57.51451707]
[null,"rs12720356","C","A",0.148332,0.0182345,{"v":4.13e-16,"d":"4.13E-16"},66.17116092]
[null,"rs12796489","A","C",-0.760367,0.0432241,{"v":2.87e-69,"d":"2.87E-69"},309.4435034]
[null,"rs1292053","G","A",0.0701035,0.00982936,{"v":9.89e-13,"d":"9.89E-13"},50.86460628]
[null,"rs1420098","C","T",-0.0952951,0.0102776,{"v":1.83e-20,"d":"1.83E-20"},85.96951677]
[null,"rs17119","A","G",0.0832994,0.0124453,{"v":2.18e-11,"d":"2.18E-11"},44.79811849]
[null,"rs181826","A","C",0.0820444,0.0104471,{"v":4.05e-15,"d":"4.05E-15"},61.67272678]
[null,"rs1847472","A","C",-0.0672805,0.0108961,{"v":6.63e-10,"d":"6.63E-10"},38.12615661]
[null,"rs1990623","G","A",0.107004,0.0133427,{"v":1.06e-15,"d":"1.06E-15"},64.31308614]
[null,"rs1990760","T","C",-0.0671151,0.0107006,{"v":3.56e-10,"d":"3.56E-10"},39.3378836]
[null,"rs2024092","A","G",0.106813,0.0121076,{"v":1.12e-18,"d":"1.12E-18"},77.8249525]
[null,"rs2108225","A","G",-0.0675096,0.0099696,{"v":1.27e-11,"d":"1.27E-11"},45.85243135]
[null,"rs2143606","G","A",-0.0566029,0.00997326,{"v":1.38e-8,"d":"1.38E-08"},32.20993514]
[null,"rs2274351","T","C",0.0604993,0.0104442,{"v":6.93e-9,"d":"6.93E-09"},33.5534443]
[null,"rs2395022","C","A",-0.181635,0.0233963,{"v":8.27e-15,"d":"8.27E-15"},60.26865244]
[null,"rs2769267","A","G",0.0680402,0.0115714,{"v":4.1e-9,"d":"4.10E-09"},34.57372056]
[null,"rs2945412","A","G",0.0563467,0.0101427,{"v":2.77e-8,"d":"2.77E-08"},30.86146795]
[null,"rs2974935","T","G",0.0687256,0.0100715,{"v":8.87e-12,"d":"8.87E-12"},46.5624189]
[null,"rs3024493","A","C",0.196922,0.0131753,{"v":1.65e-50,"d":"1.65E-50"},223.3851082]
[null,"rs34856868","A","G",-0.195275,0.0340546,{"v":9.8e-9,"d":"9.80E-09"},32.879749]
[null,"rs3806157","G","T",-0.0811629,0.0111453,{"v":3.28e-13,"d":"3.28E-13"},53.02960035]
[null,"rs406113","C","A",0.0578099,0.0105339,{"v":4.06e-8,"d":"4.06E-08"},30.11707715]
[null,"rs4151651","A","G",0.386435,0.0255511,{"v":1.13e-51,"d":"1.13E-51"},228.7286005]
[null,"rs4692386","C","T",0.0579752,0.0101746,{"v":1.21e-8,"d":"1.21E-08"},32.46658349]
[null,"rs4802307","T","G",-0.0611037,0.0108378,{"v":1.72e-8,"d":"1.72E-08"},31.78626652]
[null,"rs55693740","A","G",0.137284,0.0203551,{"v":1.54e-11,"d":"1.54E-11"},45.48625023]
[null,"rs6025","C","T",0.1775,0.0318536,{"v":2.51e-8,"d":"2.51E-08"},31.05034558]
[null,"rs6651252","C","T",-0.0908484,0.014833,{"v":9.08e-10,"d":"9.08E-10"},37.51140579]
[null,"rs7194886","T","C",-0.126026,0.0100135,{"v":2.53e-36,"d":"2.53E-36"},158.3927386]
[null,"rs7240004","G","A",-0.0665215,0.0102898,{"v":1.01e-10,"d":"1.01E-10"},41.79236687]
[null,"rs7608910","G","A",0.126444,0.0100484,{"v":2.6e-36,"d":"2.60E-36"},158.3395441]
[null,"rs941823","C","T",0.0830172,0.0115361,{"v":6.19e-13,"d":"6.19E-13"},51.78511039]
[null,"rs974801","G","A",-0.0727718,0.0101382,{"v":7.07e-13,"d":"7.07E-13"},51.52183153]
["Multiple sclerosis","rs1077667","T","C",-0.151862,0.021225,{"v":8.37e-13,"d":"8.37E-13"},51.19120256]
[null,"rs140522","C","T",-0.110596,0.017536,{"v":2.85e-10,"d":"2.85E-10"},39.77500706]
[null,"rs17207085","A","C",-0.740031,0.092995,{"v":1.75e-15,"d":"1.75E-15"},63.32469801]
[null,"rs1738074","C","T",0.113729,0.0167056,{"v":9.91e-12,"d":"9.91E-12"},46.34584272]
[null,"rs1860545","A","G",0.116534,0.0170311,{"v":7.79e-12,"d":"7.79E-12"},46.81795167]
[null,"rs206776","C","T",-0.121829,0.0175424,{"v":3.79e-12,"d":"3.79E-12"},48.229842]
[null,"rs2150879","A","G",-0.103549,0.0164769,{"v":3.29e-10,"d":"3.29E-10"},39.49419861]
[null,"rs2736197","T","G",-0.456095,0.0719372,{"v":2.29e-10,"d":"2.29E-10"},40.19722402]
[null,"rs354033","A","G",-0.107957,0.0189431,{"v":1.21e-8,"d":"1.21E-08"},32.47820439]
[null,"rs6670198","C","T",-0.145026,0.0176423,{"v":2.03e-16,"d":"2.03E-16"},67.57309814]
[null,"rs72928038","A","G",0.160521,0.0247614,{"v":9.01e-11,"d":"9.01E-11"},42.02481602]
[null,"rs8102445","T","G",-0.10075,0.0171403,{"v":4.15e-9,"d":"4.15E-09"},34.54981857]
["Psoriasis","rs11249215","A","G",0.1403,0.016,{"v":2.14e-18,"d":"2.14E-18"},76.8874942601716]
[null,"rs2111485","G","A",0.1616,0.0166,{"v":1.76e-22,"d":"1.76E-22"},94.7647601326187]
[null,"rs3129269","A","C",0.1111,0.0168,{"v":3.41e-11,"d":"3.41E-11"},43.7310480104404]
[null,"rs59960858","A","C",-0.2086,0.0243,{"v":1.06e-17,"d":"1.06E-17"},73.6879359577372]
[null,"rs73986523","C","T",-0.2122,0.038,{"v":2.41e-8,"d":"2.41E-08"},31.1819949422037]
[null,"rs8016947","G","T",0.1476,0.0162,{"v":8.18e-20,"d":"8.18E-20"},83.0085861470416]
["Rheumatoid arthritis","rs1071649","T","G",0.314811,0.0197061,{"v":1.9e-57,"d":"1.90E-57"},255.2016807]
[null,"rs11203203","A","G",0.0861777,0.0157768,{"v":4.7e-8,"d":"4.70E-08"},29.83575656]
[null,"rs2229527","G","T",0.579818,0.028764,{"v":2.3e-90,"d":"2.30E-90"},406.3216131]
[null,"rs2233434","G","A",0.287682,0.0520717,{"v":3.3e-8,"d":"3.30E-08"},30.52157655]
[null,"rs2240336","T","C",-0.105361,0.0173992,{"v":1.4e-9,"d":"1.40E-09"},36.66792247]
[null,"rs2476601","G","A",-0.593327,0.0227823,{"v":1.6e-149,"d":"1.60E-149"},678.2318615]
[null,"rs2844456","C","T",0.891598,0.0291911,{"v":1e-200,"d":"1.00E-200"},932.8726206]
[null,"rs3087243","A","G",-0.139262,0.0153069,{"v":9.2e-20,"d":"9.20E-20"},82.7705542]
[null,"rs3749946","A","C",-0.328504,0.0331689,{"v":4e-23,"d":"4.00E-23"},98.08538096]
[null,"rs4713424","A","G",-0.287682,0.0342725,{"v":4.7e-17,"d":"4.70E-17"},70.4561496]
[null,"rs61828284","T","C",-0.198451,0.0344874,{"v":8.7e-9,"d":"8.70E-09"},33.11088371]
[null,"rs6450","A","G",0.270027,0.0487793,{"v":3.1e-8,"d":"3.10E-08"},30.64279335]
[null,"rs706778","T","C",0.10436,0.0152225,{"v":7.1e-12,"d":"7.10E-12"},46.99820513]
[null,"rs7731626","A","G",-0.198451,0.0201766,{"v":7.9e-23,"d":"7.90E-23"},96.73768984]
[null,"rs8192585","A","G",0.506818,0.0333418,{"v":3.5e-52,"d":"3.50E-52"},231.0527141]
["Systemic lupus erythematosus","rs1143679","A","G",0.582216,0.0399866,{"v":5.03e-48,"d":"5.03E-48"},211.9719673]
[null,"rs13332649","G","A",-0.314711,0.0375683,{"v":5.43e-17,"d":"5.43E-17"},70.1648941]
[null,"rs17849501","T","C",0.81093,0.0498642,{"v":1.81e-59,"d":"1.81E-59"},264.4406023]
[null,"rs2299851","A","G",-0.415515,0.0531931,{"v":5.65e-15,"d":"5.65E-15"},61.0101265]
[null,"rs2431697","C","T",-0.223144,0.0292964,{"v":2.6e-14,"d":"2.60E-14"},58.00708332]
[null,"rs3747093","A","G",0.262364,0.0345055,{"v":2.88e-14,"d":"2.88E-14"},57.80573825]
[null,"rs41263824","A","G",-0.385662,0.0371039,{"v":2.64e-25,"d":"2.64E-25"},108.0223675]
[null,"rs6679677","A","C",0.336472,0.0464854,{"v":4.55e-13,"d":"4.55E-13"},52.38462379]
[null,"rs7097397","A","G",-0.18633,0.0287118,{"v":8.6e-11,"d":"8.60E-11"},42.10986435]
["Type 1 diabetes","rs11203203","A","G",0.143803,0.014405,{"v":1.81e-23,"d":"1.81E-23"},99.65697466]
[null,"rs113206908","C","T",1.1435,0.036597,{"v":1e-200,"d":"1.00E-200"},976.2919252]
[null,"rs114921900","T","G",-0.632397,0.050297,{"v":2.96e-36,"d":"2.96E-36"},158.0861306]
[null,"rs115469976","C","T",1.21283,0.034627,{"v":1e-200,"d":"1.00E-200"},1226.785006]
[null,"rs11651753","T","C",-0.086888,0.014221,{"v":9.96e-10,"d":"9.96E-10"},37.32997164]
[null,"rs116763857","G","T",1.23883,0.061909,{"v":4.45e-89,"d":"4.45E-89"},400.4185431]
[null,"rs1383265","C","T",-0.457673,0.020545,{"v":6.19e-110,"d":"6.19E-110"},496.2455497]
[null,"rs229527","A","C",0.104077,0.014138,{"v":1.82e-13,"d":"1.82E-13"},54.19159173]
[null,"rs3024493","A","C",-0.163855,0.019641,{"v":7.26e-17,"d":"7.26E-17"},69.59700276]
[null,"rs3087243","A","G",-0.19913,0.014202,{"v":1.16e-44,"d":"1.16E-44"},196.595106]
[null,"rs35327136","A","C",-0.119196,0.018978,{"v":3.37e-10,"d":"3.37E-10"},39.44762036]
[null,"rs4238595","C","T",-0.112135,0.016708,{"v":1.93e-11,"d":"1.93E-11"},45.04346309]
[null,"rs61819249","A","G",0.221691,0.039395,{"v":1.83e-8,"d":"1.83E-08"},31.66738825]
[null,"rs61839660","T","C",-0.357441,0.026,{"v":5.25e-43,"d":"5.25E-43"},188.9993752]
[null,"rs62399063","C","T",-0.555601,0.055288,{"v":9.26e-24,"d":"9.26E-24"},100.9863345]
[null,"rs663743","A","G",-0.099964,0.015092,{"v":3.5e-11,"d":"3.50E-11"},43.87246035]
[null,"rs73422013","G","A",0.413679,0.04793,{"v":6.09e-18,"d":"6.09E-18"},74.49213529]
[null,"rs74203920","T","C",0.313879,0.055717,{"v":1.77e-8,"d":"1.77E-08"},31.73565039]
[null,"rs7893467","T","G",-0.190465,0.026583,{"v":7.78e-13,"d":"7.78E-13"},51.33584453]
[null,"rs9275601","T","C",0.423157,0.015563,{"v":8.49e-163,"d":"8.49E-163"},739.2898704]
[null,"rs9332704","T","G",0.597359,0.062559,{"v":1.31e-21,"d":"1.31E-21"},91.1778943]
["Ulcerative colitis","rs10494343","C","T",0.0860299,0.0152478,{"v":1.68e-8,"d":"1.68E-08"},31.83217178]
[null,"rs10758669","A","C",-0.143218,0.0128828,{"v":1.04e-28,"d":"1.04E-28"},123.5823608]
[null,"rs10761659","G","A",0.117315,0.0126238,{"v":1.5e-20,"d":"1.50E-20"},86.35921512]
[null,"rs11083840","G","T",0.0691316,0.0125262,{"v":3.41e-8,"d":"3.41E-08"},30.45764644]
[null,"rs11230563","T","C",-0.0750666,0.0133556,{"v":1.9e-8,"d":"1.90E-08"},31.58991752]
[null,"rs11676348","T","C",0.0744362,0.0124232,{"v":2.08e-9,"d":"2.08E-09"},35.89907362]
[null,"rs12142199","A","G",-0.0983383,0.0159317,{"v":6.72e-10,"d":"6.72E-10"},38.09806866]
[null,"rs12718244","A","G",0.0717762,0.0126545,{"v":1.41e-8,"d":"1.41E-08"},32.1701252]
[null,"rs12720356","C","A",0.153279,0.0227683,{"v":1.67e-11,"d":"1.67E-11"},45.31958391]
[null,"rs12796489","A","C",-0.67649,0.0559623,{"v":1.22e-33,"d":"1.22E-33"},146.121277]
[null,"rs1431403","C","T",-0.12602,0.0148686,{"v":2.34e-17,"d":"2.34E-17"},71.83243719]
[null,"rs1801274","G","A",-0.170896,0.012653,{"v":1.43e-41,"d":"1.43E-41"},182.4141764]
[null,"rs1990760","T","C",-0.0855732,0.0134145,{"v":1.78e-10,"d":"1.78E-10"},40.69193791]
[null,"rs2070729","A","C",-0.0827543,0.0125695,{"v":4.59e-11,"d":"4.59E-11"},43.3437958]
[null,"rs2108225","A","G",-0.114735,0.0126215,{"v":9.87e-20,"d":"9.87E-20"},82.63265446]
[null,"rs2274351","T","C",0.0710979,0.0130334,{"v":4.9e-8,"d":"4.90E-08"},29.75636695]
[null,"rs2395022","C","A",-0.183896,0.029166,{"v":2.88e-10,"d":"2.88E-10"},39.7532491]
[null,"rs3024493","A","C",0.226278,0.0163471,{"v":1.42e-43,"d":"1.42E-43"},191.5953796]
[null,"rs34659678","T","C",0.209947,0.0250948,{"v":5.95e-17,"d":"5.95E-17"},69.98962656]
[null,"rs411326","T","C",-0.166985,0.0156115,{"v":1.06e-26,"d":"1.06E-26"},114.4056472]
[null,"rs4713240","G","A",0.0927208,0.0144695,{"v":1.47e-10,"d":"1.47E-10"},41.06096003]
[null,"rs4728142","A","G",0.0969671,0.0126655,{"v":1.92e-14,"d":"1.92E-14"},58.61191938]
[null,"rs61893460","A","G",0.121119,0.0125424,{"v":4.6e-22,"d":"4.60E-22"},93.24918959]
[null,"rs6426833","A","G",0.232387,0.0125836,{"v":3.77e-76,"d":"3.77E-76"},341.0324121]
[null,"rs6920220","A","G",0.146936,0.015222,{"v":4.78e-22,"d":"4.78E-22"},93.1740124]
[null,"rs7240004","G","A",-0.0823655,0.0130179,{"v":2.5e-10,"d":"2.50E-10"},40.03046394]
[null,"rs7608910","G","A",0.127099,0.0126851,{"v":1.25e-23,"d":"1.25E-23"},100.3871868]
[null,"rs9368696","A","G",0.248094,0.038233,{"v":8.64e-11,"d":"8.64E-11"},42.10537855]
[null,"rs941823","C","T",0.108669,0.0146906,{"v":1.39e-13,"d":"1.39E-13"},54.71596725]

{"sheet":"TableS4","index":3,"n_rows":14,"n_cols":8,"rows_kept":14,"merged":[[0,0,1,7],[2,0,3,0],[2,1,3,1],[2,2,2,4],[2,5,2,7],[9,13,10,20],[13,0,14,7]]}
["Table S4. Heterogeneity and pleiotropy tests for the associations between Lp(a) with the risk of IMIDs.\n"]
[]
["Exposure","Outcome","Heterogeneity test",null,null,"Pleiotropy test"]
[null,null,"Q","df","P.val","Egger_intercept","SE","P.val"]
["Lipoprotein (a) ","Celiac disease",1.96084125952253,3,0.580573896895723,0.0141652333774588,0.0128231228503082,0.384422065867291]
["Lipoprotein (a) ","Crohn's disease",61.4772695232806,7,{"v":7.64875736307618e-11,"d":"7.65E-11"},0.0258094561763404,0.0192179779504101,0.227847666522464]
["Lipoprotein (a) ","Inflammatory bowel disease",4.73108590192912,6,0.578736534674752,0.000498183057098883,0.00642512385384373,0.94120376040569]
["Lipoprotein (a) ","Multiple sclerosis",96.3231579997559,51,0.00012966134894226,0.00173277036564849,0.00653473959024033,0.791974157240567]
["Lipoprotein (a) ","Psoriasis",97.6850018042568,64,0.00426935794188662,-0.000428622786770519,0.00560176272645307,0.939251302411485]
["Lipoprotein (a) ","Rheumatoid arthritis",54.585011951528,45,0.154917158439982,0.00863399003302358,0.00550918295124701,0.124232514675409]
["Lipoprotein (a) ","Systemic lupus erythematosus",108.0876393,56,{"v":3.66e-5,"d":"3.66E-05"},0.00682191295240179,0.0105768386933822,0.521617700045216]
["Lipoprotein (a) ","Type 1 diabetes",106.552441695607,72,0.00508930559379213,0.0101370202504677,0.00430776264736417,0.0213864389194411]
["Lipoprotein (a) ","Ulcerative colitis",10.2021472844175,7,0.177404466973096,0.00941987117159082,0.00840527365691216,0.305254001107381]
["Df, degree of freedom."]

{"sheet":"TableS5","index":4,"n_rows":16,"n_cols":11,"rows_kept":16,"merged":[[0,0,1,7],[0,8,1,10]]}
["Table S5. The results of MR-PRESSO analysis between Lp(a) with the risk of IMIDs."]
[]
["Exposure","Outcome","MR Analysis","Causal Estimate","SD","T","P.val","RSSobs","Global test P-value","Distortion test P-value","Remove nSNP"]
["Lipoprotein(a)","Celiac disease","Raw",-0.2270976,0.1937076,-1.172373,0.3256732,14.72083,0.523]
["Lipoprotein(a)","Crohn's disease","Raw",0.2077366,0.4407642,0.4713099,0.651755,113.5108,0.066]
["Lipoprotein(a)","Inflammatory bowel disease","Raw",-0.05601793,0.1846918,-0.303305,0.7693953,21.92428,0.203]
["Lipoprotein(a)","multiple sclerosis","Raw",0.00651947,0.10328634,0.06312035,0.9499174,98.81667,"<0.001",0.131,2]
["Lipoprotein(a)","multiple sclerosis","Outlier-corrected",-0.02676205,0.08727739,-0.30663207,0.7604227]
["Lipoprotein(a)","Psoriasis","Raw",0.05692091,0.07698314,0.7393945,0.4623709,101.3678,"<0.001",0.934,1]
["Lipoprotein(a)","Psoriasis","Outlier-corrected",0.04977324,0.07264491,0.6851579,0.4957576]
["Lipoprotein(a)","Rheumatoid arthritis","Raw",-0.06307846,0.09082741,-0.694487,0.4907958,58.93994,0.186]
["Lipoprotein(a)","Systemic lupus erythematosus","Raw",0.03847972,0.1329206,0.2894941,0.7732725,111.2155,"<0.001",0.166,3]
["Lipoprotein(a)","Systemic lupus erythematosus","Outlier-corrected",0.01303484,0.1112952,0.1171195,0.9072081]
["Lipoprotein(a)","Type 1 diabetes","Raw",0.05490741,0.05520072,0.9946865,0.32322,108.8217,0.002,0.774,1]
["Lipoprotein(a)","Type 1 diabetes","Outlier-corrected",0.04517639,0.05268744,0.8574413,0.3940862]
["Lipoprotein(a)","Ulcerative colitis","Raw",-0.03744523,0.18411,-0.2033851,0.8433581,18.00654,0.341]

{"sheet":"TableS6","index":5,"n_rows":14,"n_cols":8,"rows_kept":14,"merged":[[0,0,1,7],[2,0,3,0],[2,1,3,1],[2,2,2,4],[2,5,2,7],[13,0,14,7]]}
["Table S6. Heterogeneity and pleiotropy tests for the associations between IMIDs with the risk of Lp(a)."]
[]
["Exposure","Outcome","Heterogeneity test",null,null,"Pleiotropy test"]
[null,null,"Q","df","P.val","Egger_intercept","SE","P.val"]
["Celiac disease","Lipoprotein (a) ",13.1151585407463,9,0.157464322939177,0.00267594602137986,0.00249972363550826,0.315626709993148]
["Crohn's disease","Lipoprotein (a) ",100.65875858084,43,{"v":1.59635412140341e-6,"d":"1.60E-06"},{"v":-7.92398927075813e-5,"d":"-7.92E-05"},0.00130469457924717,0.951858794167471]
["Inflammatory bowel disease","Lipoprotein (a) ",45.3165391212786,39,0.225278344281214,-0.000983323298069093,0.000919757225013707,0.291763792614142]
["multiple sclerosis","Lipoprotein (a) ",6.53900798887695,11,0.835093676074583,-0.000496140552172037,0.00136552859130306,0.723919786715745]
["Psoriasis ","Lipoprotein (a) ",6.19523905916997,5,0.287682261613415,0.00811203821675997,0.0049081423550706,0.173721064319981]
["Rheumatoid arthritis","Lipoprotein (a) ",11.5881121957785,14,0.639342526852936,-0.001971774904082,0.00127742029482243,0.146681185071751]
["Systemic lupus erythematosus","Lipoprotein (a) ",8.55543601717562,8,0.381173682934906,-0.000329708063012778,0.0025788793419777,0.901863602743219]
["Type 1 diabetes","Lipoprotein (a) ",26.9734249214643,20,0.136013322059906,-0.00160400268699872,0.00111516690664957,0.166603142116138]
["Ulcerative colitis","Lipoprotein (a) ",53.7508403029994,28,0.0023958003024347,-0.0025896313938074,0.00155708075677823,0.107852668076658]
["Df, degree of freedom."]

{"sheet":"TableS7","index":6,"n_rows":14,"n_cols":10,"rows_kept":14,"merged":[[0,0,1,9]]}
["Table S7. MR-PRESSO analysis for the association between IMIDs with the risk of Lp(a). "]
[]
["Exposure","MR Analysis","Causal Estimate","SD","T","P-value","RSSobs","Global test P-value","Distortion test P-value","Remove nSNP"]
["Celiac disease","Raw",-0.001616582,0.001843773,-0.8767792,0.4034024,15.68808,0.241]
["Crohn's disease","Raw",-0.0004604442,0.004276498,-0.1076685,0.9147481,105.1611,"<0.001",0.632,1]
["Crohn's disease","Outlier-corrected",-0.0033602084,0.00344905,-0.9742418,0.3353856]
["Inflammatory bowel disease","Raw",-0.00531878,0.00401418,-1.324998,0.1926914,47.58221,0.241]
["multiple sclerosis","Raw",-0.008086227,0.003404308,-2.375293,0.03680606,7.476598,0.848]
["Psoriasis","Raw",0.003329791,0.007165115,0.4647226,0.6616648,7.87957,0.376]
["Rheumatoid arthritis","Raw",0.003302715,0.002468039,1.338194,0.2021632,12.66556,0.679]
["Systemic lupus erythematosus","Raw",-0.001769909,0.002808746,-0.6301421,0.5461749,10.23271,0.43]
["Type 1 diabetes","Raw",-0.001966947,0.002261114,-0.8699017,0.394675,28.01195,0.196]
["Ulcerative colitis","Raw",0.003834777,0.004798454,0.7991694,0.4306894,57.02813,0.006,0.784,1]
["Ulcerative colitis","Outlier-corrected",0.005215175,0.004384527,1.1894499,0.2442517]

{"sheet":"TableS8","index":7,"n_rows":39,"n_cols":5,"rows_kept":39,"merged":[[0,0,1,4]]}
["Table S8. Estimates from multivariable mendelian randomization analysis of lipid traits and IMIDs."]
[]
["Outcome(traits)","Biomarker","SE","P.val","OR(95%CI)"]
["Celiac disease","Lp(a)",{"v":0.0657573483550947,"d":"0.066"},{"v":0.813461102986593,"d":"0.813"},"1.02(0.89-1.16)"]
[null,"HDL",{"v":0.155677122584255,"d":"0.156"},{"v":0.107100544586605,"d":"0.107"},"1.29(0.95-1.74)"]
[null,"LDL",{"v":0.221440021521044,"d":"0.221"},{"v":0.145736276139176,"d":"0.146"},"1.38(0.89-2.13)"]
[null,"TG",{"v":0.202174993999714,"d":"0.202"},{"v":0.428431849092076,"d":"0.428"},"1.17(0.79-1.74)"]
["Crohn's disease","Lp(a)",{"v":1.25094902066474,"d":"1.251"},{"v":0.130191367977806,"d":"0.130"},"6.64 (0.57-77.1)"]
[null,"HDL",{"v":0.184481666403687,"d":"0.184"},{"v":0.829020612588825,"d":"0.829"},"1.04(0.72-1.49)"]
[null,"LDL",{"v":0.253514005999,"d":"0.254"},{"v":0.219738648316418,"d":"0.220"},"0.73(0.45-1.20)"]
[null,"TG",{"v":0.20668279745004,"d":"0.207"},{"v":0.051630733222936,"d":"0.052"},"1.50(1.00-2.24)"]
["Inflammatory bowel disease","Lp(a)",{"v":0.392436192288855,"d":"0.392"},{"v":0.861195887310063,"d":"0.861"},"1.07(0.50-2.31)"]
[null,"HDL",{"v":0.138537172789741,"d":"0.139"},{"v":0.951350163083684,"d":"0.951"},"0.99(0.76-1.30)"]
[null,"LDL",{"v":0.143913406846525,"d":"0.144"},{"v":0.589423906488102,"d":"0.589"},"0.93(0.70-1.23)"]
[null,"TG",{"v":0.165318110839258,"d":"0.165"},{"v":0.288258548339341,"d":"0.288"},"1.19(0.86-1.65)"]
["Psoriasis","Lp(a)",{"v":0.0426710306626395,"d":"0.043"},{"v":0.959398081923265,"d":"0.959"},"1.00(0.92-1.08)"]
[null,"HDL",{"v":0.0880010651544268,"d":"0.088"},{"v":0.753792807467441,"d":"0.754"},"1.03(0.87-1.22)"]
[null,"LDL",{"v":0.111631804225539,"d":"0.112"},{"v":0.0445912676087385,"d":"0.045"},"0.80(0.64-0.99)"]
[null,"TG",{"v":0.0998324464221745,"d":"0.100"},{"v":0.190798335053105,"d":"0.191"},"1.14(0.94-1.39)"]
["Multiple sclerosis","Lp(a)",{"v":0.104412149820209,"d":"0.104"},{"v":0.445416572442926,"d":"0.445"},"1.08(0.88-1.33)"]
[null,"HDL",{"v":0.0923886097189043,"d":"0.092"},{"v":0.880790783494545,"d":"0.881"},"1.01(0.85-1.22)"]
[null,"LDL",{"v":0.12567372563939,"d":"0.126"},{"v":0.593589776302697,"d":"0.594"},"1.07(0.84-1.37)"]
[null,"TG",{"v":0.107544034343581,"d":"0.108"},{"v":0.214689957767106,"d":"0.215"},"0.88(0.71-1.08)"]
["Rheumatoid arthritis","Lp(a)",{"v":0.0562302121746556,"d":"0.056"},{"v":0.877542405594441,"d":"0.878"},"1.01(0.90-1.13)"]
[null,"HDL",{"v":0.0878852290974902,"d":"0.088"},{"v":0.933459211903854,"d":"0.933"},"0.99(0.84-1.18)"]
[null,"LDL",{"v":0.123561518589037,"d":"0.124"},{"v":0.371157232974978,"d":"0.371"},"0.90(0.70-1.14)"]
[null,"TG",{"v":0.10194944181189,"d":"0.102"},{"v":0.256199450833665,"d":"0.256"},"0.89(0.73-1.09)"]
["Systemic lupus erythematosus","Lp(a)",{"v":0.0806551060362815,"d":"0.081"},{"v":0.534788198174217,"d":"0.535"},"1.05(0.90-1.23)"]
[null,"HDL",{"v":0.152051762882279,"d":"0.152"},{"v":0.932478939526928,"d":"0.932"},"1.01(0.75-1.36)"]
[null,"LDL",{"v":0.203741000791062,"d":"0.204"},{"v":0.446579981623645,"d":"0.447"},"1.17(0.78-1.74)"]
[null,"TG",{"v":0.171709545330319,"d":"0.172"},{"v":0.580615220434866,"d":"0.581"},"0.91(0.65-1.27)"]
["Type 1 diabetes","Lp(a)",{"v":0.0441447890212473,"d":"0.044"},{"v":0.556289466680724,"d":"0.556"},"0.97(0.89-1.06)"]
[null,"HDL",{"v":0.086924512237084,"d":"0.087"},{"v":0.010830479264921,"d":"0.011"},"0.80(0.68-0.95)"]
[null,"LDL",{"v":0.116471212948017,"d":"0.116"},{"v":0.576549510837663,"d":"0.577"},"1.07(0.85-1.34)"]
[null,"TG",{"v":0.102868635017909,"d":"0.103"},{"v":0.0326168386088069,"d":"0.033"},"0.80(0.66-0.98)"]
["Ulcerative colitis","Lp(a)",{"v":0.938812089997432,"d":"0.939"},{"v":0.158256991850567,"d":"0.158"},"3.76(0.60-23.68)"]
[null,"HDL",{"v":0.137418922358615,"d":"0.137"},{"v":0.859060727717012,"d":"0.859"},"0.98(0.75-1.28)"]
[null,"LDL",{"v":0.19008702426105,"d":"0.190"},{"v":0.652034000455371,"d":"0.652"},"0.92(0.63-1.33)"]
[null,"TG",{"v":0.154168096298334,"d":"0.154"},{"v":0.912534389675177,"d":"0.913"},"0.98(0.73-1.33)"]