{"text_format":"3","workbook":"xlsx","n_sheets":3,"sheets":["oxphos","dogma","metab"],"read":"whole","date_system":"1900"}

{"sheet":"oxphos","index":0,"n_rows":43,"n_cols":13,"rows_kept":43}
["Cluster","group","ID","Description","setSize","enrichmentScore","NES","pvalue","p.adjust","qvalue","rank","leading_edge","core_enrichment"]
["COX","COX","mtDNA","mtDNA",12,-0.7471412055760336,-2.052079599114351,0.0003018260353159267,0.00633834674163446,0.005083385857952449,1115,"tags=50%, list=8%, signal=46%","mt-Nd3/mt-Nd2/mt-Nd5/mt-Nd4/mt-Cytb/mt-Nd6"]
["COX","COX","OXPHOS subunits","OXPHOS subunits",94,-0.38422977927115,-1.683042242159164,0.001146011331323542,0.01203311897889719,0.009650621737461404,4441,"tags=44%, list=31%, signal=30%","Ndufv2/Ndufa9/Ndufab1/Atp5c1/Ndufc1/Cox7a2/Cox7a2l/Cox6c/Ndufs4/Cycs/Ndufb9/Ndufb5/Ndufa1/Atp5j2/Ndufa4/Cox7b/Ndufa3/Cox6b1/Atp5l/Atp5mpl/Atp5o/Ndufs1/Cox5b/Ndufa5/Uqcrfs1/Uqcr10/Atp5j/Uqcr11/Ndufb11/mt-Nd3/Ndufs6/Cox8a/Sdhd/Atp5h/Atpif1/mt-Nd2/mt-Nd5/mt-Nd4/Ndufv3/mt-Cytb/mt-Nd6"]
["COX","COX","CI subunits","CI subunits",43,-0.4606581987311643,-1.733411440843531,0.002338312643233327,0.01327160300187802,0.01064389213183199,1883,"tags=23%, list=13%, signal=20%","Ndufs1/Ndufa5/Ndufb11/mt-Nd3/Ndufs6/mt-Nd2/mt-Nd5/mt-Nd4/Ndufv3/mt-Nd6"]
["COX","COX","Complex I","Complex I",64,-0.4079280042825798,-1.640360084639956,0.002527924381310099,0.01327160300187802,0.01064389213183199,4441,"tags=39%, list=31%, signal=27%","Ndufv2/Ndufa9/Aifm1/Ndufab1/Dmac2/Ndufc1/Tmem126b/Ndufs4/Ndufb9/Ndufb5/Ndufa1/Nubpl/Ndufa3/Ndufaf2/Ndufs1/Ndufa5/Ndufb11/mt-Nd3/Ndufs6/Foxred1/mt-Nd2/mt-Nd5/mt-Nd4/Ndufv3/mt-Nd6"]
["COX","COX","OXPHOS","OXPHOS",156,-0.3069807591781832,-1.451497392660499,0.008650216648117957,0.03633090992209542,0.0291375718673447,4441,"tags=39%, list=31%, signal=27%","Ndufv2/Ndufa9/Aifm1/Ndufab1/Dmac2/Sdhaf4/Atp5c1/Lyrm7/Ndufc1/Surf1/Timm21/Cox7a2/Sco1/Cox7a2l/Tmem126b/Cox6c/Cmc1/Ndufs4/Cycs/Ndufb9/Ndufb5/Ndufa1/Atp5j2/Ndufa4/Nubpl/Cox7b/Ndufa3/Coa6/Ndufaf2/Smim20/Cox6b1/Atp5l/Atpaf2/Atp5mpl/Atp5o/Ndufs1/Cox5b/Uqcc3/Cep89/Ndufa5/Uqcrfs1/Uqcr10/Atp5j/Uqcr11/Ndufb11/mt-Nd3/Cmc2/Ndufs6/Cox8a/Coa4/Sdhd/Atp5h/Foxred1/Atpif1/mt-Nd2/Higd1a/mt-Nd5/mt-Nd4/Ndufv3/mt-Cytb/mt-Nd6"]
["COX","COX","CV subunits","CV subunits",17,-0.468910960038762,-1.408764240773783,0.0720164609053498,0.2520576131687243,0.2021514692079994,2429,"tags=41%, list=17%, signal=34%","Atp5j2/Atp5l/Atp5mpl/Atp5o/Atp5j/Atp5h/Atpif1"]
["COX","COX","Complex III","Complex III",16,-0.4636571056515479,-1.368845582514287,0.0880503144654088,0.2641509433962264,0.2118503806686527,1837,"tags=31%, list=13%, signal=27%","Uqcc3/Uqcrfs1/Uqcr10/Uqcr11/mt-Cytb"]
["COX","COX","CIII subunits","CIII subunits",10,-0.5528765168144697,-1.414801785200724,0.1057884231536926,0.2776946107784432,0.2227124697972476,1620,"tags=40%, list=11%, signal=36%","Uqcrfs1/Uqcr10/Uqcr11/mt-Cytb"]
["COX","COX","Complex V","Complex V",21,-0.3723244157870938,-1.18096984422646,0.2266112266112266,0.5287595287595288,0.4240677924888451,2429,"tags=33%, list=17%, signal=28%","Atp5l/Atpaf2/Atp5mpl/Atp5o/Atp5j/Atp5h/Atpif1"]
["COX","COX","CV assembly factors","CV assembly factors",4,0.6004821508282918,1.131042524814357,0.3614931237721022,0.7591355599214146,0.608830524247751,1398,"tags=50%, list=10%, signal=45%","Fmc1/Atpaf1"]
["COX","COX","Complex IV","Complex IV",44,-0.2592950694938764,-0.9801752409519948,0.5032679738562091,0.884020618556701,0.7089889672635196,4066,"tags=41%, list=28%, signal=29%","Surf1/Timm21/Cox7a2/Sco1/Cox7a2l/Cox6c/Cmc1/Ndufa4/Cox7b/Coa6/Smim20/Cox6b1/Cox5b/Cep89/Cmc2/Cox8a/Coa4/Higd1a"]
["COX","COX","CIV subunits","CIV subunits",18,-0.3175920927666686,-0.9667546047211376,0.5051546391752577,0.884020618556701,0.7089889672635196,5166,"tags=61%, list=36%, signal=39%","Cox5a/Cox7c/Cox7a1/Cox7a2/Cox7a2l/Cox6c/Ndufa4/Cox7b/Cox6b1/Cox5b/Cox8a"]
["COX","COX","Respirasome assembly","Respirasome assembly",4,-0.4733385887369451,-0.9220233127561189,0.565922920892495,0.9141831799032611,0.7331794926542444,142,"tags=75%, list=1%, signal=74%","Rab5if/Cox7a2l/Higd1a"]
["COX","COX","CI assembly factors","CI assembly factors",21,-0.2778868805311588,-0.8814249404506431,0.6382536382536382,0.9457905544147843,0.7585287654454411,4335,"tags=29%, list=30%, signal=20%","Aifm1/Dmac2/Tmem126b/Nubpl/Ndufaf2/Foxred1"]
["COX","COX","Cytochrome C","Cytochrome C",2,-0.5703955763665228,-0.8788936983093922,0.675564681724846,0.9457905544147843,0.7585287654454411,3635,"tags=100%, list=25%, signal=75%","Cycs"]
["COX","COX","CIV assembly factors","CIV assembly factors",26,-0.2391924369181919,-0.7948391980450737,0.7974413646055437,0.9822485207100592,0.7877682371609498,4066,"tags=38%, list=28%, signal=28%","Surf1/Timm21/Sco1/Cmc1/Coa6/Smim20/Cep89/Cmc2/Coa4/Higd1a"]
["COX","COX","OXPHOS assembly factors","OXPHOS assembly factors",63,-0.1767710930645559,-0.7113136625241723,0.9354120267260579,0.9822485207100592,0.7877682371609498,4335,"tags=33%, list=30%, signal=23%","Aifm1/Dmac2/Sdhaf4/Lyrm7/Surf1/Timm21/Sco1/Cox7a2l/Tmem126b/Cmc1/Nubpl/Coa6/Ndufaf2/Smim20/Atpaf2/Uqcc3/Cep89/Cmc2/Coa4/Foxred1/Higd1a"]
["COX","COX","CII subunits","CII subunits",4,-0.3544534474097266,-0.69044516879685,0.8113590263691683,0.9822485207100592,0.7877682371609498,824,"tags=25%, list=6%, signal=24%","Sdhd"]
["COX","COX","Complex II","Complex II",8,0.2569213080024048,0.6029261075895214,0.9180952380952381,0.9822485207100592,0.7877682371609498,3459,"tags=38%, list=24%, signal=29%","Sdha/Sdhaf1/Sdhc"]
["COX","COX","CII assembly factors","CII assembly factors",4,0.294587092297016,0.5548716613636911,0.9489194499017681,0.9822485207100592,0.7877682371609498,10169,"tags=100%, list=71%, signal=29%","Sdhaf1/Sdhaf3/Sdhaf2/Sdhaf4"]
["COX","COX","CIII assembly factors","CIII assembly factors",6,-0.2238609669211959,-0.4970128513388654,0.9822485207100592,0.9822485207100592,0.7877682371609498,4218,"tags=50%, list=29%, signal=35%","Bcs1l/Lyrm7/Uqcc3"]
["DKO","DKO","mtDNA","mtDNA",13,0.8744168670901109,2.438485698662838,8.005395203290017E-08,1.681132992690904E-06,1.348277086869898E-06,62,"tags=46%, list=0%, signal=46%","mt-Cytb/mt-Nd6/mt-Nd5/mt-Nd4/mt-Nd3/mt-Nd2"]
["DKO","DKO","Complex I","Complex I",64,0.4218150149989635,1.745474924747017,0.0008100390391531918,0.008505409911108514,0.006821381382342667,3096,"tags=30%, list=21%, signal=24%","mt-Nd6/mt-Nd5/mt-Nd4/mt-Nd3/mt-Nd2/Ndufs1/Acad9/Aifm1/Ndufa9/Ndufaf4/Ndufb5/Ndufa5/Ndufb2/Foxred1/Ndufaf7/mt-Nd1/Ndufs6/Timmdc1/Ndufab1"]
["DKO","DKO","CI subunits","CI subunits",43,0.4731505549896849,1.826354671878507,0.001411312101684746,0.009879184711793224,0.007923155658581033,1853,"tags=23%, list=13%, signal=20%","mt-Nd6/mt-Nd5/mt-Nd4/mt-Nd3/mt-Nd2/Ndufs1/Ndufa9/Ndufb5/Ndufa5/Ndufb2"]
["DKO","DKO","OXPHOS subunits","OXPHOS subunits",95,0.324545189504834,1.450323841649483,0.01453672438916508,0.07631780304311665,0.06120726058595821,4796,"tags=46%, list=33%, signal=31%","mt-Cytb/mt-Nd6/mt-Nd5/mt-Nd4/mt-Nd3/mt-Nd2/Ndufs1/Atp5c1/Atpif1/Atp5h/Uqcrc2/Ndufa9/Ndufb5/Ndufa5/Hccs/Ndufb2/Sdhb/Atp5mpl/Uqcr10/Sdhd/Cox7c/Atp5j/mt-Nd1/Atp5l/Ndufs6/Ndufab1/Cox7b/Ndufb9/Cox6b1/mt-Co3/Cox8a/Ndufa10/Cox5b/Cycs/Ndufa4/Cox6c/Atp5g1/Cox7a2l/Cox7a2/Ndufc1/mt-Co1/Ndufv1/Ndufa3/Cox7a1"]
["DKO","DKO","OXPHOS","OXPHOS",157,0.282489855302835,1.36496270399615,0.01904431302150674,0.0799861146903283,0.06414926491454902,3096,"tags=26%, list=21%, signal=21%","mt-Cytb/mt-Nd6/mt-Nd5/mt-Nd4/mt-Nd3/mt-Nd2/Ndufs1/Cep89/Coa4/Atp5c1/Atpif1/Atp5h/Cmc2/Acad9/Lyrm7/Uqcrc2/Aifm1/Ndufa9/Ndufaf4/Ndufb5/Ndufa5/Timm21/Hccs/Ndufb2/Sdhb/Atp5mpl/Foxred1/Uqcr10/Cmc1/Sdhd/Cox7c/Ndufaf7/Atp5j/mt-Nd1/Coa5/Smim20/Atp5l/Ndufs6/Sdhaf3/Timmdc1/Ndufab1"]
["DKO","DKO","Cytochrome C","Cytochrome C",2,0.7227433387710712,1.116708192615016,0.334020618556701,0.8656716417910448,0.6942729959226425,4081,"tags=100%, list=28%, signal=72%","Hccs/Cycs"]
["DKO","DKO","Respirasome assembly","Respirasome assembly",4,-0.604661095186427,-1.104120650038699,0.3696060037523452,0.8656716417910448,0.6942729959226425,1339,"tags=50%, list=9%, signal=45%","Higd1a/Higd2a"]
["DKO","DKO","CV subunits","CV subunits",18,0.3537903328030551,1.075663840177661,0.3240740740740741,0.8656716417910448,0.6942729959226425,2895,"tags=33%, list=20%, signal=27%","Atp5c1/Atpif1/Atp5h/Atp5mpl/Atp5j/Atp5l"]
["DKO","DKO","CI assembly factors","CI assembly factors",21,0.3240332408750748,1.020530339065273,0.4272517321016167,0.8656716417910448,0.6942729959226425,3074,"tags=29%, list=21%, signal=23%","Acad9/Aifm1/Ndufaf4/Foxred1/Ndufaf7/Timmdc1"]
["DKO","DKO","CV assembly factors","CV assembly factors",4,-0.531911226718178,-0.9712782483977804,0.5196998123827392,0.8656716417910448,0.6942729959226425,4976,"tags=75%, list=34%, signal=50%","Tmem70/Atpaf1/Fmc1"]
["DKO","DKO","CIII subunits","CIII subunits",10,0.3795882979009844,0.9600249489861435,0.508695652173913,0.8656716417910448,0.6942729959226425,2208,"tags=30%, list=15%, signal=26%","mt-Cytb/Uqcrc2/Uqcr10"]
["DKO","DKO","Complex III","Complex III",16,0.3199743968783752,0.9447594529432077,0.5352422907488987,0.8656716417910448,0.6942729959226425,2208,"tags=25%, list=15%, signal=21%","mt-Cytb/Lyrm7/Uqcrc2/Uqcr10"]
["DKO","DKO","CIV assembly factors","CIV assembly factors",26,0.2661426529012404,0.8985220048111124,0.6004618937644342,0.8656716417910448,0.6942729959226425,2838,"tags=27%, list=19%, signal=22%","Cep89/Coa4/Cmc2/Timm21/Cmc1/Coa5/Smim20"]
["DKO","DKO","Complex V","Complex V",22,0.2728322922315076,0.8666002678737803,0.6572769953051644,0.8656716417910448,0.6942729959226425,2895,"tags=27%, list=20%, signal=22%","Atp5c1/Atpif1/Atp5h/Atp5mpl/Atp5j/Atp5l"]
["DKO","DKO","OXPHOS assembly factors","OXPHOS assembly factors",63,0.2090672822698366,0.8645157921523149,0.7385786802030457,0.8656716417910448,0.6942729959226425,3074,"tags=24%, list=21%, signal=19%","Cep89/Coa4/Cmc2/Acad9/Lyrm7/Aifm1/Ndufaf4/Timm21/Foxred1/Cmc1/Ndufaf7/Coa5/Smim20/Sdhaf3/Timmdc1"]
["DKO","DKO","CII assembly factors","CII assembly factors",4,0.4436167691796625,0.8518543650430319,0.6396588486140725,0.8656716417910448,0.6942729959226425,3763,"tags=50%, list=26%, signal=37%","Sdhaf3/Sdhaf2"]
["DKO","DKO","Complex II","Complex II",8,0.3523848075862392,0.844947576514433,0.6602564102564102,0.8656716417910448,0.6942729959226425,3763,"tags=50%, list=26%, signal=37%","Sdhb/Sdhd/Sdhaf3/Sdhaf2"]
["DKO","DKO","CII subunits","CII subunits",4,0.3998041261831616,0.7677232100155581,0.7420042643923241,0.8656716417910448,0.6942729959226425,2301,"tags=50%, list=16%, signal=42%","Sdhb/Sdhd"]
["DKO","DKO","CIV subunits","CIV subunits",18,0.2481080517485806,0.7543475187928358,0.8240740740740741,0.9108187134502925,0.7304811736944702,5101,"tags=72%, list=35%, signal=47%","Cox7c/Cox7b/Cox6b1/mt-Co3/Cox8a/Cox5b/Ndufa4/Cox6c/Cox7a2l/Cox7a2/mt-Co1/Cox7a1/mt-Co2"]
["DKO","DKO","Complex IV","Complex IV",44,0.1904962726017536,0.7357347006622356,0.9207920792079208,0.9207920792079208,0.7384798630238965,4796,"tags=45%, list=33%, signal=31%","Cep89/Coa4/Cmc2/Timm21/Cmc1/Cox7c/Coa5/Smim20/Cox7b/Cox6b1/mt-Co3/Cox8a/Cox5b/Surf1/Ndufa4/Cox6c/Cox7a2l/Cox7a2/mt-Co1/Cox7a1"]
["DKO","DKO","CIII assembly factors","CIII assembly factors",6,0.2898241988564979,0.6363528828041798,0.8966244725738397,0.9207920792079208,0.7384798630238965,5895,"tags=83%, list=40%, signal=50%","Lyrm7/Uqcc1/Uqcc3/Ttc19/Bcs1l"]

{"sheet":"dogma","index":1,"n_rows":43,"n_cols":13,"rows_kept":43}
["Cluster","group","ID","Description","setSize","enrichmentScore","NES","pvalue","p.adjust","qvalue","rank","leading_edge","core_enrichment"]
["COX","COX","Transcription","Transcription",8,-0.6656721999553205,-1.554102248418297,0.02821931289914891,0.5926055708821272,0.5926055708821272,273,"tags=75%, list=2%, signal=74%","Mterf1b/Tefm/Top1mt/Tfb2m/Tfam/Mterf1a"]
["COX","COX","mt-tRNA modifications","mt-tRNA modifications",21,-0.4216429052928202,-1.31357360785853,0.1191489361702128,0.625531914893617,0.625531914893617,4822,"tags=62%, list=33%, signal=41%","Mto1/Hsd17b10/Osgepl1/Nsun2/Nsun3/Trmt10c/Trmt1/Dus2/Trit1/Qtrt1/Trmt2b/Alkbh1/Trnt1"]
["COX","COX","mtDNA maintainance","mtDNA maintainance",31,-0.3795279725039712,-1.308228964342834,0.1091703056768559,0.625531914893617,0.625531914893617,749,"tags=23%, list=5%, signal=21%","Apex1/Ppa2/Ssbp1/Tfb2m/Tfam/Pif1/Mterf1a"]
["COX","COX","Mitochondrial central dogma","Mitochondrial central dogma",227,-0.239694653895426,-1.194505268976237,0.1030150753768844,0.625531914893617,0.625531914893617,3075,"tags=26%, list=21%, signal=21%","Rmnd1/Trmt1/Mettl17/Polb/Vars2/Mrps22/Dus2/Trit1/Mrpl35/Mrps21/Qtrt1/Ybey/Top3a/Pdf/Mrps6/Mrpl51/Mrpl47/Mterf2/Mrpl24/Mrpl38/Mief1/Mrpl41/Mrps18c/Lactb2/Rars2/Mtrf1/Mrpl30/Mutyh/Trmt2b/Mrps36/Gfm2/Mrpl20/Mrpl33/Mrrf/Hemk1/Alkbh1/Trnt1/Mrpl50/Mrpl9/Fastkd3/Gatb/Myg1/Ptcd2/Ptcd3/Apex1/Tfb1m/Cars2/Dars2/Mrps9/Pnpt1/Ppa2/Ssbp1/Rbfa/Guf1/Mrpl34/Tfb2m/Mrpl18/Tfam/Pif1/Mterf1a"]
["COX","COX","mtRNA metabolism","mtRNA metabolism",74,-0.2877678806257221,-1.216004651039922,0.1533477321814255,0.6440604751619871,0.644060475161987,3727,"tags=36%, list=26%, signal=27%","Nsun2/Ptcd1/Nsun3/Trmt10c/Top1mt/Rmnd1/Trmt1/Mettl17/Dus2/Trit1/Qtrt1/Ybey/Mrpl47/Lactb2/Trmt2b/Alkbh1/Trnt1/Fastkd3/Myg1/Ptcd2/Tfb1m/Mrps9/Pnpt1/Ppa2/Tfb2m/Tfam/Mterf1a"]
["COX","COX","mtDNA nucleoid","mtDNA nucleoid",11,-0.4766387156625674,-1.221158483579411,0.1919191919191919,0.6546762589928058,0.6546762589928058,480,"tags=36%, list=3%, signal=35%","Mterf2/Ssbp1/Tfam/Mterf1a"]
["COX","COX","Translation","Translation",153,-0.2324333230388167,-1.104395713364551,0.2182254196642686,0.6546762589928058,0.6546762589928058,3075,"tags=25%, list=21%, signal=20%","Rmnd1/Mettl17/Vars2/Mrps22/Mrpl35/Mrps21/Ybey/Pdf/Mrps6/Mrpl51/Mrpl47/Mrpl24/Mrpl38/Mief1/Mrpl41/Mrps18c/Rars2/Mtrf1/Mrpl30/Mrps36/Gfm2/Mrpl20/Mrpl33/Mrrf/Hemk1/Mrpl50/Mrpl9/Gatb/Ptcd3/Tfb1m/Cars2/Dars2/Mrps9/Ppa2/Rbfa/Guf1/Mrpl34/Mrpl18/Mterf1a"]
["COX","COX","Mitochondrial ribosome","Mitochondrial ribosome",82,-0.2591341432403622,-1.113017603790173,0.2566964285714285,0.6738281249999999,0.6738281249999999,4412,"tags=51%, list=31%, signal=36%","Mrpl55/Mrps23/Mrpl22/Mrps31/Mrpl42/Mrps16/Mrps11/Aurkaip1/Mrps30/Mrpl3/Mrpl58/Mrps15/Mrpl44/Mrpl32/Mrps33/Mrps25/Mrpl13/Mrpl46/Mrps14/Mrpl40/Mrpl1/Mrpl36/Mrps22/Mrpl35/Mrps21/Mrps6/Mrpl51/Mrpl47/Mrpl24/Mrpl38/Mrpl41/Mrps18c/Mrpl30/Mrps36/Mrpl20/Mrpl33/Mrpl50/Mrpl9/Ptcd3/Mrps9/Mrpl34/Mrpl18"]
["COX","COX","mtDNA modifications","mtDNA modifications",1,0.8583917296884757,1.13388639006394,0.3036437246963563,0.684317718940937,0.6843177189409368,2042,"tags=100%, list=14%, signal=86%","Mettl4"]
["COX","COX","mtDNA replication","mtDNA replication",14,-0.3933508710615926,-1.098260144552893,0.3258655804480652,0.684317718940937,0.6843177189409368,480,"tags=43%, list=3%, signal=41%","Exog/Top1mt/Top3a/Ssbp1/Tfb2m/Tfam"]
["COX","COX","mt-tRNA synthetases","mt-tRNA synthetases",22,0.3309619345977585,1.057022305941511,0.37243947858473,0.7012195121951219,0.7012195121951219,3282,"tags=41%, list=23%, signal=32%","Mars2/Aars2/Sars2/Wars2/Yars2/Ears2/Qrsl1/Nars2/Tars2"]
["COX","COX","Mitochondrial ribosome assembly","Mitochondrial ribosome assembly",24,-0.3112488198482787,-1.004892606227575,0.4602150537634409,0.7012195121951219,0.7012195121951219,802,"tags=29%, list=6%, signal=28%","Mettl17/Ybey/Mief1/Ptcd3/Tfb1m/Rbfa/Mterf1a"]
["COX","COX","Translation factors","Translation factors",16,-0.3432376959814743,-0.9923389130960953,0.44,0.7012195121951219,0.7012195121951219,4572,"tags=50%, list=32%, signal=34%","Mrpl58/Mtif2/Timm21/Mtrf1l/Mtrf1/Gfm2/Mrrf/Hemk1"]
["COX","COX","mtDNA repair","mtDNA repair",9,0.4029943639188103,0.9897151329938318,0.467479674796748,0.7012195121951219,0.7012195121951219,647,"tags=22%, list=4%, signal=21%","Ung/Lig3"]
["COX","COX","mtDNA stability and decay","mtDNA stability and decay",3,-0.5958893581048963,-0.9875346279562568,0.5509355509355509,0.7713097713097712,0.7713097713097713,4333,"tags=100%, list=30%, signal=70%","Mgme1/Exog"]
["COX","COX","mtRNA granules","mtRNA granules",27,0.2685618474573783,0.8936555076912077,0.6439393939393939,0.803757828810021,0.803757828810021,2234,"tags=26%, list=15%, signal=22%","Noa1/Dhx30/Trub2/Mrm1/Grsf1/Rpusd3/Pus1"]
["COX","COX","Polycistronic mtRNA processing","Polycistronic mtRNA processing",12,-0.3314819638038173,-0.8734031657682136,0.6619433198380567,0.803757828810021,0.803757828810021,5122,"tags=58%, list=36%, signal=38%","Fastkd2/Fastkd5/Hsd17b10/Trmt10c/Ybey/Fastkd3/Ptcd2"]
["COX","COX","mtRNA stability and decay","mtRNA stability and decay",17,-0.2823433931096634,-0.8350964481235491,0.6889352818371608,0.803757828810021,0.803757828810021,1947,"tags=18%, list=14%, signal=15%","Lactb2/Fastkd3/Pnpt1"]
["COX","COX","mt-mRNA modifications","mt-mRNA modifications",4,0.4264980347495401,0.7959671957733945,0.7318007662835249,0.8088324258923171,0.808832425892317,1020,"tags=25%, list=7%, signal=23%","Angel2"]
["COX","COX","mt-rRNA modifications","mt-rRNA modifications",17,-0.2558304374715295,-0.7566781970753892,0.8100208768267223,0.8505219206680584,0.8505219206680584,3009,"tags=29%, list=21%, signal=23%","Mettl17/Trit1/Trmt2b/Myg1/Tfb1m"]
["COX","COX","fMet processing","fMet processing",3,-0.3491252685046545,-0.5785860872551122,0.9397089397089398,0.9397089397089398,0.9397089397089398,2495,"tags=100%, list=17%, signal=83%","Mtfmt/Pdf"]
["DKO","DKO","Mitochondrial central dogma","Mitochondrial central dogma",227,0.3037421122534778,1.530233191857583,0.0003203991059939995,0.006728381225873988,0.005396195469372622,2306,"tags=26%, list=16%, signal=23%","Ptcd3/Tfb2m/Mrpl9/Pif1/Mrpl50/Mrpl18/Ssbp1/Trmt5/Mrps9/Mterf1a/Alkbh1/Hsd17b10/Gfm2/Tfam/Fastkd3/Myg1/Pnpt1/Dars2/Mrps17/Mrpl33/Guf1/Fastkd2/Iars2/Ptcd2/Gtpbp10/Mrpl47/Dus2/Mrpl46/Rars2/Mettl17/Trmt10c/Hemk1/Mrpl49/Mrps6/Qtrt1/Mrpl1/Mtif2/Nsun3/Gatb/Ybey/Mtrf1/Mrpl24/Mrps22/Timm21/Mrpl35/Lactb2/Mrrf/Mrps23/Cars2/Mrpl30/Mettl5/Pdf/Cdk5rap1/Mtpap/Mrps31/Polq/Rmnd1/Mrps18b/Tefm/Exd2"]
["DKO","DKO","mtRNA metabolism","mtRNA metabolism",74,0.3981240890303617,1.676440119710858,0.001955106901305788,0.02052862246371077,0.01646405811625927,3500,"tags=46%, list=24%, signal=35%","Tfb2m/Trmt5/Mrps9/Mterf1a/Alkbh1/Hsd17b10/Tfam/Fastkd3/Myg1/Pnpt1/Fastkd2/Ptcd2/Mrpl47/Dus2/Mettl17/Trmt10c/Qtrt1/Nsun3/Ybey/Lactb2/Mettl5/Cdk5rap1/Mtpap/Rmnd1/Tefm/Tfb1m/Trub2/Mettl15/Lrpprc/Top1mt/Pde12/Trmt1/Trnt1/Mto1"]
["DKO","DKO","Polycistronic mtRNA processing","Polycistronic mtRNA processing",12,0.6276774955527197,1.645454372106678,0.02569843754931936,0.1091910662322816,0.08757178244193006,1730,"tags=50%, list=12%, signal=44%","Hsd17b10/Fastkd3/Fastkd2/Ptcd2/Trmt10c/Ybey"]
["DKO","DKO","mt-tRNA modifications","mt-tRNA modifications",21,0.4872685102783957,1.541785441344559,0.02599787291244799,0.1091910662322816,0.08757178244193006,4451,"tags=67%, list=30%, signal=47%","Trmt5/Alkbh1/Hsd17b10/Dus2/Trmt10c/Qtrt1/Nsun3/Cdk5rap1/Trmt1/Trnt1/Mto1/Nsun2/Trit1/Osgepl1"]
["DKO","DKO","Translation","Translation",153,0.2795115390849944,1.321265649910898,0.02063058108849351,0.1091910662322816,0.08757178244193006,2406,"tags=26%, list=16%, signal=22%","Ptcd3/Mrpl9/Mrpl50/Mrpl18/Mrps9/Mterf1a/Gfm2/Dars2/Mrps17/Mrpl33/Guf1/Fastkd2/Iars2/Gtpbp10/Mrpl47/Mrpl46/Rars2/Mettl17/Hemk1/Mrpl49/Mrps6/Mrpl1/Mtif2/Gatb/Ybey/Mtrf1/Mrpl24/Mrps22/Timm21/Mrpl35/Mrrf/Mrps23/Cars2/Mrpl30/Pdf/Mrps31/Rmnd1/Mrps18b/Exd2/Mrpl51"]
["DKO","DKO","Transcription","Transcription",8,0.5829611174981455,1.375816062330994,0.1338912133891213,0.3246268656716418,0.2603523734709909,3044,"tags=62%, list=21%, signal=50%","Tfb2m/Mterf1a/Tfam/Tefm/Top1mt"]
["DKO","DKO","mtDNA replication","mtDNA replication",14,0.4835830613885918,1.329040957596794,0.146551724137931,0.3246268656716418,0.2603523734709909,545,"tags=21%, list=4%, signal=21%","Tfb2m/Ssbp1/Tfam"]
["DKO","DKO","Translation factors","Translation factors",16,0.447678623216497,1.294962430400252,0.1528384279475982,0.3246268656716418,0.2603523734709909,3300,"tags=50%, list=22%, signal=39%","Gfm2/Hemk1/Mtif2/Mtrf1/Timm21/Mrrf/Mtrf1l/Mtif3"]
["DKO","DKO","mtDNA repair","mtDNA repair",9,-0.5443240140347939,-1.290186932204363,0.1608527131782946,0.3246268656716418,0.2603523734709909,1983,"tags=22%, list=13%, signal=19%","Polg/Ung"]
["DKO","DKO","mt-rRNA modifications","mt-rRNA modifications",17,0.4298221916063323,1.265402111413652,0.171875,0.3246268656716418,0.2603523734709909,2765,"tags=41%, list=19%, signal=33%","Myg1/Mettl17/Mettl5/Mtpap/Tfb1m/Trub2/Mettl15"]
["DKO","DKO","mtDNA maintainance","mtDNA maintainance",31,0.3588084895213449,1.261854215705412,0.1513859275053305,0.3246268656716418,0.2603523734709909,545,"tags=16%, list=4%, signal=16%","Tfb2m/Pif1/Ssbp1/Mterf1a/Tfam"]
["DKO","DKO","mtDNA nucleoid","mtDNA nucleoid",11,0.4890193868803182,1.261836325432343,0.185501066098081,0.3246268656716418,0.2603523734709909,545,"tags=27%, list=4%, signal=26%","Ssbp1/Mterf1a/Tfam"]
["DKO","DKO","mtRNA stability and decay","mtRNA stability and decay",17,0.4038201669011212,1.188851813161161,0.2388392857142857,0.334375,0.2681704260651629,3081,"tags=41%, list=21%, signal=33%","Fastkd3/Pnpt1/Fastkd2/Lactb2/Mtpap/Lrpprc/Pde12"]
["DKO","DKO","mtRNA granules","mtRNA granules",27,0.3497497365215325,1.181441490604071,0.2258771929824561,0.334375,0.2681704260651629,2764,"tags=41%, list=19%, signal=33%","Mrps9/Alkbh1/Hsd17b10/Fastkd2/Ptcd2/Mrpl47/Trmt10c/Mtpap/Rmnd1/Tfb1m/Trub2"]
["DKO","DKO","Mitochondrial ribosome","Mitochondrial ribosome",82,0.2672606397898832,1.148285487727426,0.21,0.334375,0.2681704260651629,4119,"tags=39%, list=28%, signal=28%","Ptcd3/Mrpl9/Mrpl50/Mrpl18/Mrps9/Mrps17/Mrpl33/Mrpl47/Mrpl46/Mrpl49/Mrps6/Mrpl1/Mrpl24/Mrps22/Mrpl35/Mrps23/Mrpl30/Mrps31/Mrps18b/Mrpl51/Mrpl22/Mrpl21/Mrps18c/Mrps36/Mrpl41/Mrps14/Mrpl38/Mrps16/Mrpl34/Mrpl32/Mrpl20/Mrpl42"]
["DKO","DKO","fMet processing","fMet processing",3,0.6459112228944328,1.110770284539678,0.3978723404255319,0.4838012958963283,0.3880110643780076,5212,"tags=100%, list=35%, signal=65%","Pdf/Mtfmt/Metap1d"]
["DKO","DKO","mt-mRNA modifications","mt-mRNA modifications",4,0.5630706199750182,1.062852333536452,0.4146868250539957,0.4838012958963283,0.3880110643780076,3081,"tags=75%, list=21%, signal=59%","Myg1/Mtpap/Pde12"]
["DKO","DKO","Mitochondrial ribosome assembly","Mitochondrial ribosome assembly",24,0.3244677052370235,1.055455285997667,0.3725490196078431,0.4838012958963283,0.3880110643780076,1730,"tags=25%, list=12%, signal=22%","Ptcd3/Mterf1a/Fastkd2/Gtpbp10/Mettl17/Ybey"]
["DKO","DKO","mtDNA modifications","mtDNA modifications",1,0.7185482226602324,0.9563080263015891,0.5703275529865125,0.6101052631578948,0.4893074792243767,4142,"tags=100%, list=28%, signal=72%","Mettl4"]
["DKO","DKO","mt-tRNA synthetases","mt-tRNA synthetases",22,0.2901130784331194,0.9340279501162075,0.5810526315789474,0.6101052631578948,0.4893074792243767,1919,"tags=23%, list=13%, signal=20%","Dars2/Iars2/Rars2/Gatb/Cars2"]
["DKO","DKO","mtDNA stability and decay","mtDNA stability and decay",3,-0.4475636845798335,-0.7832652129823302,0.7406015037593985,0.7406015037593985,0.593966118303277,2220,"tags=100%, list=15%, signal=85%","Exog/Endog"]

{"sheet":"metab","index":2,"n_rows":149,"n_cols":13,"rows_kept":149}
["Cluster","group","ID","Description","setSize","enrichmentScore","NES","pvalue","p.adjust","qvalue","rank","leading_edge","core_enrichment"]
["COX","COX","Nucleotide synthesis and processing","Nucleotide synthesis and processing",21,-0.6215852618788706,-1.962424099365509,0.0006389829465421266,0.04317952951598086,0.04238104603986741,3800,"tags=67%, list=26%, signal=49%","Nme4/Cmpk2/Sucla2/Dguok/Nudt2/Dut/Ak4/Fhit/Tk2/Nt5dc2/Ak3/Ak2/Paics/Suclg1"]
["COX","COX","Glycolysis","Glycolysis",16,-0.658685309328955,-1.916919033425261,0.001167014311242726,0.04317952951598086,0.04238104603986741,1188,"tags=56%, list=8%, signal=52%","Eno1b/Pfkl/Gpi1/Pfkp/Aldoa/Tpi1/Eno1/Pkm/Pgk1"]
["COX","COX","Nucleotide metabolism","Nucleotide metabolism",31,-0.5206559393222095,-1.805692200385139,0.00179548639487631,0.04428866440694898,0.04346967061279488,3800,"tags=52%, list=26%, signal=38%","Nme4/Cmpk2/Sucla2/Dguok/Nudt2/Dut/Ak4/Fhit/Slc25a23/Tk2/Nt5dc2/Ppa2/Ak3/Ak2/Paics/Suclg1"]
["COX","COX","Glycerol phosphate shuttle","Glycerol phosphate shuttle",1,0.996600291403594,1.326251242389133,0.004196325741365762,0.0776320262152666,0.07619644109322042,50,"tags=100%, list=0%, signal=100%","Gpd2"]
["COX","COX","Serine metabolism","Serine metabolism",3,0.8713168010433144,1.510788130389475,0.02599883054778287,0.3847826921071865,0.3776672226941091,571,"tags=67%, list=4%, signal=64%","Sfxn3/Shmt2"]
["COX","COX","Heme-containing proteins","Heme-containing proteins",9,-0.5940793551891699,-1.461306100132049,0.07547169811320754,0.7219512195121951,0.7086007702182285,854,"tags=33%, list=6%, signal=31%","Cyb5b/Sdhd/mt-Cytb"]
["COX","COX","Proline metabolism","Proline metabolism",6,0.6694596002344345,1.439243144508804,0.1044176706827309,0.7219512195121951,0.7086007702182285,1081,"tags=50%, list=7%, signal=46%","Prodh/Pycr2/Aldh4a1"]
["COX","COX","Copper metabolism","Copper metabolism",6,0.6612877375819486,1.421674799389338,0.1144578313253012,0.7219512195121951,0.7086007702182285,2940,"tags=67%, list=20%, signal=53%","Chchd7/Cox17/Cox11/Slc25a3"]
["COX","COX","Itaconate metabolism","Itaconate metabolism",6,-0.6546851787997001,-1.402836074289961,0.1051587301587302,0.7219512195121951,0.7086007702182285,177,"tags=67%, list=1%, signal=66%","Sucla2/Clybl/Suclg1/Auh"]
["COX","COX","Molybdenum cofactor synthesis and proteins","Molybdenum cofactor synthesis and proteins",3,0.8080191188797191,1.401035412687465,0.08739837398373984,0.7219512195121951,0.7086007702182285,382,"tags=33%, list=3%, signal=32%","Suox"]
["COX","COX","Coenzyme Q metabolism","Coenzyme Q metabolism",13,0.5034045241992898,1.36921266216137,0.1341463414634146,0.7219512195121951,0.7086007702182285,3069,"tags=46%, list=21%, signal=36%","Coq8b/Coq2/Coq5/Coq10b/Coq3/Coq10a"]
["COX","COX","Heme synthesis and processing","Heme synthesis and processing",13,0.4945789814976229,1.345208021287732,0.1463414634146341,0.7219512195121951,0.7086007702182285,4458,"tags=46%, list=31%, signal=32%","Fech/Fdx1/Alas1/Cox15/Cpox/Fdxr"]
["COX","COX","Folate and 1-C metabolism","Folate and 1-C metabolism",21,0.4246137206269508,1.303619364190315,0.1442495126705653,0.7219512195121951,0.7086007702182285,2557,"tags=33%, list=18%, signal=27%","Mthfd1l/Sfxn3/Shmt2/Fpgs/Gtpbp3/Chdh/Mthfsl"]
["COX","COX","Metals and cofactors","Metals and cofactors",108,0.2763446893239386,1.18828604087706,0.1451327433628319,0.7219512195121951,0.7086007702182285,4008,"tags=38%, list=28%, signal=28%","Pank2/Iba57/Suox/Fech/Fth1/Naxe/Naxd/Aco2/Coq8b/Coq2/Fdx1/Chchd7/Alas1/Coq5/Cpt1c/Cox17/Cox11/Spr/Coq10b/Rsad1/Iscu/Nmnat3/Dna2/Cyc1/Fxn/Nfu1/Slc25a3/Coq3/Coq10a/Sirt4/Nfs1/Ndufs7/Cisd1/Sdhc/Slc25a42/Coasy/Cox15/Glrx2/Glrx5/Ndufs8/mt-Co1"]
["COX","COX","Metabolism","Metabolism",403,0.2302096851579901,1.173859877334357,0.0680379746835443,0.7219512195121951,0.7086007702182285,3577,"tags=30%, list=25%, signal=23%","Glud1/Ogdh/Fasn/Gpd2/Bckdk/Pank2/Gldc/Acot7/Iba57/Suox/Mthfd1l/Sfxn3/Ldhd/Zadh2/Prps2/Shmt2/Fech/Fth1/Mdh2/Prodh/Txnrd1/Aldh1b1/Naxe/Pccb/Naxd/Pycr2/Aco2/Rfk/Plscr3/Coq8b/Txnrd2/Acsf3/Sdha/Aldh4a1/Acadl/Pdpr/Slc25a11/Acot2/Idi1/Aldh2/Pdp1/Acsl6/Coq2/Hadha/Lipt2/Acaca/Eci1/Abhd10/L2hgdh/Fdx1/Akr7a5/Dlat/Acly/Taz/Chchd7/Dcxr/Maoa/Mccc2/Alas1/Gpam/Fpgs/Coq5/Bdh1/Cpt1c/Gtpbp3/Cox17/Cox11/Spr/Coq10b/Rsad1/Iscu/Lactb/Aldh3a2/Pgls/Nmnat3/Hibadh/Dna2/Ldhb/Slc25a24/Prdx6/Chdh/Cyc1/Stard7/Fxn/Mthfsl/Mmadhc/Dglucy/Slc25a25/Prps1/Nfu1/Pdhx/Slc25a10/Ptges2/Hmgcl/Idh2/Slc25a3/Coq3/Gsr/Agpat4/Coq10a/Agk/Mccc1/Slc25a33/Sirt4/Nfs1/Echs1/Osbpl1a/Ndufs7/Guk1/Acad10/Rpia/Abhd11/Cisd1/Dlst/Sdhc/Slc25a29/Slc25a42/Pdha1/Coasy/Mpc2"]
["COX","COX","Cytochromes","Cytochromes",4,-0.6875094590191722,-1.300072145147725,0.1732283464566929,0.7567155067155067,0.7427221900906111,854,"tags=75%, list=6%, signal=71%","Cycs/Cyb5b/mt-Cytb"]
["COX","COX","Iron homeostasis","Iron homeostasis",4,0.6735614142577373,1.272520568526523,0.2024291497975708,0.7567155067155067,0.7427221900906111,599,"tags=25%, list=4%, signal=24%","Fth1"]
["COX","COX","GABA metabolism","GABA metabolism",5,0.6241272380796746,1.272117421337375,0.2081632653061224,0.7567155067155067,0.7427221900906111,1659,"tags=40%, list=12%, signal=35%","Glud1/Akr7a5"]
["COX","COX","Lysine metabolism","Lysine metabolism",13,-0.4647221002539077,-1.269160056654852,0.1843137254901961,0.7567155067155067,0.7427221900906111,3732,"tags=54%, list=26%, signal=40%","Dld/Etfa/Hadhb/Acat1/Etfdh/Etfb/Acaa2"]
["COX","COX","Propanoate metabolism","Propanoate metabolism",3,0.7123246437349817,1.235109452096086,0.2296747967479675,0.7567155067155067,0.7427221900906111,840,"tags=33%, list=6%, signal=31%","Pccb"]
["COX","COX","Xenobiotic metabolism","Xenobiotic metabolism",13,0.4530163385676589,1.232161566127013,0.2032520325203252,0.7567155067155067,0.7427221900906111,1764,"tags=38%, list=12%, signal=34%","Aldh1b1/Aldh2/Abhd10/Akr7a5/Maoa"]
["COX","COX","Vitamin B2 metabolism","Vitamin B2 metabolism",3,0.7004717686417616,1.214557589696114,0.2459349593495935,0.7567155067155067,0.7427221900906111,971,"tags=33%, list=7%, signal=31%","Rfk"]
["COX","COX","Eicosanoid metabolism","Eicosanoid metabolism",3,0.6923877593504961,1.200540615309096,0.2560975609756098,0.7567155067155067,0.7427221900906111,4436,"tags=100%, list=31%, signal=69%","Zadh2/Ptges2/Mgst3"]
["COX","COX","Choline and betaine metabolism","Choline and betaine metabolism",6,-0.5582624073226763,-1.196224795172597,0.2658730158730159,0.7567155067155067,0.7427221900906111,3413,"tags=67%, list=24%, signal=51%","Etfa/Sardh/Etfdh/Etfb"]
["COX","COX","Branched-chain amino acid dehydrogenase complex","Branched-chain amino acid dehydrogenase complex",6,0.5560515029932481,1.195431827994697,0.2550200803212851,0.7567155067155067,0.7427221900906111,85,"tags=17%, list=1%, signal=17%","Bckdk"]
["COX","COX","Carbohydrate metabolism","Carbohydrate metabolism",419,0.2093339508099006,1.071127995105725,0.2362204724409449,0.7567155067155067,0.7427221900906111,3462,"tags=28%, list=24%, signal=22%","Glud1/Ogdh/Fasn/Gpd2/Bckdk/Pank2/Gldc/Acot7/Iba57/Suox/Mthfd1l/Sfxn3/Ldhd/Zadh2/Prps2/Shmt2/Fech/Fth1/Mdh2/Prodh/Txnrd1/Aldh1b1/Naxe/Pccb/Naxd/Pycr2/Aco2/Rfk/Plscr3/Coq8b/Txnrd2/Acsf3/Sdha/Aldh4a1/Acadl/Pdpr/Slc25a11/Acot2/Idi1/Aldh2/Pdp1/Acsl6/Coq2/Hadha/Lipt2/Acaca/Eci1/Abhd10/L2hgdh/Fdx1/Akr7a5/Dlat/Acly/Taz/Chchd7/Dcxr/Maoa/Mccc2/Alas1/Gpam/Fpgs/Coq5/Bdh1/Cpt1c/Gtpbp3/Cox17/Cox11/Spr/Coq10b/Rsad1/Iscu/Lactb/Aldh3a2/Pgls/Nmnat3/Eno3/Hibadh/Dna2/Foxk1/Ldhb/Slc25a24/Eno2/Prdx6/Chdh/Cyc1/Stard7/Fxn/Mthfsl/Mmadhc/Dglucy/Slc25a25/Prps1/Nfu1/Pdhx/Slc25a10/Ptges2/Hmgcl/Idh2/Slc25a3/Coq3/Gsr/Agpat4/Coq10a/Agk/Mccc1/Slc25a33/Sirt4/Nfs1/Echs1/Osbpl1a/Ndufs7/Guk1/Acad10/Rpia/Abhd11/Cisd1/Dlst/Sdhc/Slc25a29"]
["COX","COX","Amidoxime reducing complex","Amidoxime reducing complex",2,-0.7431622377901348,-1.162193060376629,0.2959381044487427,0.7989443378119001,0.7841701181937569,854,"tags=100%, list=6%, signal=94%","Cyb5b"]
["COX","COX","Selenoproteins","Selenoproteins",5,0.558007356404346,1.137349623612748,0.3122448979591837,0.7989443378119001,0.7841701181937569,1024,"tags=40%, list=7%, signal=37%","Txnrd1/Txnrd2"]
["COX","COX","Vitamin D metabolism","Vitamin D metabolism",3,0.651460300452473,1.129575933994449,0.3434959349593496,0.7989443378119001,0.7841701181937569,4458,"tags=67%, list=31%, signal=46%","Fdx1/Fdxr"]
["COX","COX","Gluconeogenesis","Gluconeogenesis",8,0.4607412250924706,1.09202080065979,0.3373983739837398,0.7989443378119001,0.7841701181937569,4127,"tags=62%, list=29%, signal=45%","Mdh2/Slc25a11/Slc25a10/Mpc2/Slc25a1"]
["COX","COX","Vitamin metabolism","Vitamin metabolism",46,0.2939519288359415,1.079842238526157,0.3249551166965889,0.7989443378119001,0.7841701181937569,2566,"tags=24%, list=18%, signal=20%","Mthfd1l/Sfxn3/Shmt2/Rfk/Acaca/Fdx1/Fpgs/Gtpbp3/Chdh/Mthfsl/Mmadhc"]
["COX","COX","Fe-S-containing proteins","Fe-S-containing proteins",29,0.3237509783407851,1.06120985615069,0.345489443378119,0.7989443378119001,0.7841701181937569,3929,"tags=45%, list=27%, signal=33%","Fech/Aco2/Fdx1/Rsad1/Iscu/Dna2/Nfu1/Nfs1/Ndufs7/Cisd1/Glrx2/Glrx5/Ndufs8"]
["COX","COX","Detoxification","Detoxification",39,0.2981398187960028,1.051407210624881,0.372972972972973,0.8363636363636363,0.8208974524764,2432,"tags=23%, list=17%, signal=19%","Txnrd1/Aldh1b1/Txnrd2/Aldh2/Abhd10/Akr7a5/Maoa/Aldh3a2/Prdx6"]
["COX","COX","Vitamin A metabolism","Vitamin A metabolism",4,-0.5597969658005515,-1.058569351487592,0.4271653543307087,0.8500761927089439,0.8343564338110545,5040,"tags=75%, list=35%, signal=49%","Dhrs4/Rdh13/Akr1b10"]
["COX","COX","Type II fatty acid synthesis","Type II fatty acid synthesis",7,-0.4650097080982438,-1.031165815949308,0.4268292682926829,0.8500761927089439,0.8343564338110545,567,"tags=57%, list=4%, signal=55%","Ndufab1/Mecr/Mcat/Cbr4"]
["COX","COX","Q-linked reactions, other","Q-linked reactions, other",10,0.4040860736937058,1.021620789533586,0.4106382978723404,0.8500761927089439,0.8343564338110545,736,"tags=20%, list=5%, signal=19%","Gpd2/Prodh"]
["COX","COX","Malate-aspartate shuttle","Malate-aspartate shuttle",6,0.4711539950665403,1.01291423286781,0.429718875502008,0.8500761927089439,0.8343564338110545,2882,"tags=50%, list=20%, signal=40%","Mdh2/Slc25a11/Slc25a10"]
["COX","COX","Fatty acid oxidation","Fatty acid oxidation",40,-0.2695910728524503,-1.000856758776824,0.4365256124721604,0.8500761927089439,0.8343564338110545,3413,"tags=35%, list=24%, signal=27%","Etfa/Acacb/Acadm/Hadhb/Eci2/Acat1/Acsf2/Etfdh/Slc25a20/Etfb/Acss1/Crot/Decr1/Acaa2"]
["COX","COX","Urea cycle","Urea cycle",3,0.5860106862813128,1.016091951922762,0.4857723577235772,0.8511225616488775,0.8353834531119849,5969,"tags=100%, list=41%, signal=59%","Slc25a15/Car5b/Slc25a13"]
["COX","COX","Glycine cleavage system","Glycine cleavage system",4,0.5366553653322603,1.013871899636615,0.4493927125506073,0.8511225616488775,0.8353834531119849,227,"tags=25%, list=2%, signal=25%","Gldc"]
["COX","COX","TCA cycle","TCA cycle",20,0.3255026946446569,0.9904124400186091,0.4611005692599621,0.8511225616488775,0.8353834531119849,1069,"tags=20%, list=7%, signal=19%","Ogdh/Mdh2/Aco2/Sdha"]
["COX","COX","Glutamate metabolism","Glutamate metabolism",6,-0.4525521353726779,-0.9697125909611893,0.503968253968254,0.8511225616488775,0.8353834531119849,1468,"tags=50%, list=10%, signal=45%","Gls2/Slc25a12/Gpt2"]
["COX","COX","Glycine metabolism","Glycine metabolism",13,-0.3514444917696514,-0.9597979326606296,0.4980392156862745,0.8511225616488775,0.8353834531119849,3732,"tags=54%, list=26%, signal=40%","Dld/Etfa/Sardh/Amt/Etfdh/Etfb/Gcat"]
["COX","COX","Coenzyme A metabolism","Coenzyme A metabolism",4,0.5077508515086181,0.9592642757655573,0.5060728744939271,0.8511225616488775,0.8353834531119849,3559,"tags=75%, list=25%, signal=56%","Pank2/Slc25a42/Coasy"]
["COX","COX","Fe-S cluster biosynthesis","Fe-S cluster biosynthesis",22,0.3031816552574298,0.9326832814902384,0.5493230174081238,0.903331184182248,0.8866266245885509,3847,"tags=36%, list=27%, signal=27%","Iba57/Fdx1/Iscu/Fxn/Nfu1/Nfs1/Cisd1/Glrx5"]
["COX","COX","Amino acid metabolism","Amino acid metabolism",68,0.2328876103752313,0.9201343259489866,0.5978835978835979,0.9323412698412699,0.9151002506265665,2598,"tags=24%, list=18%, signal=19%","Glud1/Bckdk/Gldc/Sfxn3/Shmt2/Prodh/Pycr2/Aldh4a1/Hadha/Akr7a5/Maoa/Mccc2/Hibadh/Ldhb/Chdh/Dglucy"]
["COX","COX","TCA-associated","TCA-associated",13,0.3295949401594538,0.8964670434149422,0.5873983739837398,0.9323412698412699,0.9151002506265665,4127,"tags=46%, list=29%, signal=33%","Slc25a11/L2hgdh/Acly/Abhd11/Mpc2/Slc25a1"]
["COX","COX","Lipid metabolism","Lipid metabolism",107,0.2063205176363759,0.8840361136111451,0.7229129662522202,0.9323412698412699,0.9151002506265665,1904,"tags=17%, list=13%, signal=15%","Fasn/Acot7/Zadh2/Pccb/Plscr3/Acsf3/Acadl/Acot2/Idi1/Acsl6/Hadha/Lipt2/Acaca/Eci1/Fdx1/Taz/Gpam/Cpt1c"]
["COX","COX","Vitamin C metabolism","Vitamin C metabolism",2,0.5605846969811435,0.863532251507168,0.6989690721649484,0.9323412698412699,0.9151002506265665,3831,"tags=50%, list=27%, signal=37%","Glrx2"]
["COX","COX","Vitamin B1 metabolism","Vitamin B1 metabolism",1,0.6478179421355721,0.8621002401968351,0.7276507276507277,0.9323412698412699,0.9151002506265665,5077,"tags=100%, list=35%, signal=65%","Slc25a19"]
["COX","COX","Electron carriers","Electron carriers",14,-0.3073114103144109,-0.8580821283953488,0.6352705410821643,0.9323412698412699,0.9151002506265665,3635,"tags=50%, list=25%, signal=37%","Cycs/Etfa/Etfrf1/Etfdh/Etfb/Cyb5b/mt-Cytb"]
["COX","COX","Vitamin B6 metabolism","Vitamin B6 metabolism",2,0.5565500971412711,0.8573172993288128,0.7010309278350515,0.9323412698412699,0.9151002506265665,6393,"tags=100%, list=44%, signal=56%","Plpbp/Pnpo"]
["COX","COX","Catechol metabolism","Catechol metabolism",2,0.5538031242560287,0.8530858251319667,0.7072164948453609,0.9323412698412699,0.9151002506265665,1764,"tags=50%, list=12%, signal=44%","Maoa"]
["COX","COX","Vitamin B12 metabolism","Vitamin B12 metabolism",3,0.4907326434985292,0.8508880491050833,0.6727642276422764,0.9323412698412699,0.9151002506265665,2566,"tags=33%, list=18%, signal=27%","Mmadhc"]
["COX","COX","Glyoxylate metabolism","Glyoxylate metabolism",4,0.4479786781769555,0.8463401705837119,0.6497975708502024,0.9323412698412699,0.9151002506265665,2378,"tags=50%, list=16%, signal=42%","Aldh4a1/Ldhb"]
["COX","COX","Nucleotide import","Nucleotide import",7,0.3541139280306321,0.8084053911087686,0.707843137254902,0.9323412698412699,0.9151002506265665,3226,"tags=43%, list=22%, signal=33%","Slc25a24/Slc25a25/Slc25a33"]
["COX","COX","ROS and glutathione metabolism","ROS and glutathione metabolism",24,0.254420674055995,0.8052340004665768,0.751434034416826,0.9323412698412699,0.9151002506265665,4449,"tags=33%, list=31%, signal=23%","Txnrd1/Txnrd2/Aldh3a2/Prdx6/Gsr/Glrx2/Hagh/Gpx1"]
["COX","COX","Lipoate insertion","Lipoate insertion",4,0.4203168170628093,0.7940802185045602,0.7246963562753036,0.9323412698412699,0.9151002506265665,1519,"tags=25%, list=11%, signal=22%","Lipt2"]
["COX","COX","Sulfur metabolism","Sulfur metabolism",11,0.301400927317201,0.7890666049905278,0.7394957983193278,0.9323412698412699,0.9151002506265665,382,"tags=9%, list=3%, signal=9%","Suox"]
["COX","COX","Ketone metabolism","Ketone metabolism",6,-0.3659616654523858,-0.7841696172885414,0.7559523809523809,0.9323412698412699,0.9151002506265665,3232,"tags=50%, list=22%, signal=39%","Hadhb/Acat1/Acaa2"]
["COX","COX","Cholesterol-associated","Cholesterol-associated",2,0.504768181627691,0.7775517361024233,0.7793814432989691,0.9454791279364543,0.9279951611325086,1236,"tags=50%, list=9%, signal=46%","Idi1"]
["COX","COX","Phospholipid metabolism","Phospholipid metabolism",23,-0.2387561972429672,-0.7724141922322915,0.8118609406952966,0.9525745257452575,0.9349593495934959,1909,"tags=22%, list=13%, signal=19%","Gpat2/Agpat5/Prelid1/Pgs1/Sptlc2"]
["COX","COX","Pyruvate metabolism","Pyruvate metabolism",13,0.2697784594169275,0.7337718770000783,0.8252032520325203,0.9525745257452575,0.9349593495934959,3577,"tags=46%, list=25%, signal=35%","Pdpr/Pdp1/Dlat/Pdhx/Pdha1/Mpc2"]
["COX","COX","Branched-chain amino acid metabolism","Branched-chain amino acid metabolism",25,-0.2244143868652644,-0.7329337252189808,0.8853503184713376,0.9525745257452575,0.9349593495934959,3788,"tags=40%, list=26%, signal=30%","Ppm1k/Dld/Bckdha/Etfa/Acat1/Hibch/Etfdh/Etfb/Aldh6a1/Auh"]
["COX","COX","Cardiolipin synthesis","Cardiolipin synthesis",16,0.2509443024581326,0.7210843521189545,0.837573385518591,0.9525745257452575,0.9349593495934959,1855,"tags=25%, list=13%, signal=22%","Plscr3/Hadha/Taz/Gpam"]
["COX","COX","Creatine metabolism","Creatine metabolism",2,0.4439356092145434,0.6838444185395518,0.8618556701030928,0.9525745257452575,0.9349593495934959,8016,"tags=100%, list=56%, signal=44%","Ckmt1/Gatm"]
["COX","COX","NAD biosynthesis and metabolism","NAD biosynthesis and metabolism",13,0.2508616445299519,0.6823199308495986,0.8882113821138211,0.9525745257452575,0.9349593495934959,847,"tags=15%, list=6%, signal=14%","Naxe/Naxd"]
["COX","COX","Tetrahydobiopterin synthesis","Tetrahydobiopterin synthesis",3,0.3770653359858219,0.6537987484076762,0.8800813008130082,0.9525745257452575,0.9349593495934959,2115,"tags=33%, list=15%, signal=28%","Spr"]
["COX","COX","Kynurenine metabolism","Kynurenine metabolism",3,-0.3755464575671362,-0.6469937290821465,0.8627450980392157,0.9525745257452575,0.9349593495934959,9003,"tags=67%, list=62%, signal=25%","Got2/Kyat3"]
["COX","COX","Pentose-Phosphate Shunt","Pentose-Phosphate Shunt",13,0.2301890096129291,0.6260923203932786,0.9288617886178862,0.9709219858156027,0.9529675251959686,3373,"tags=31%, list=23%, signal=24%","Prps2/Pgls/Prps1/Rpia"]
["COX","COX","Cholesterol, bile acid, steroid synthesis","Cholesterol, bile acid, steroid synthesis",10,0.2389618572544985,0.604149504696369,0.9446808510638298,0.9709219858156027,0.9529675251959686,5006,"tags=50%, list=35%, signal=33%","Fdx1/Osbpl1a/Fdxr/Cyp11a1/Dhrs1"]
["COX","COX","Biotin utilizing proteins","Biotin utilizing proteins",5,0.2828492646669566,0.5765130172853762,0.9408163265306122,0.9709219858156027,0.9529675251959686,3219,"tags=40%, list=22%, signal=31%","Acaca/Mccc1"]
["COX","COX","Carnitine shuttle","Carnitine shuttle",5,-0.2495254179863123,-0.507678523936216,0.97265625,0.9859803082191781,0.967747386445566,4054,"tags=60%, list=28%, signal=43%","Cpt1b/Cpt1a/Slc25a20"]
["COX","COX","Carnitine synthesis and transport","Carnitine synthesis and transport",6,-0.195985672110235,-0.419951115105842,1,1,0.9815078236130869,4054,"tags=33%, list=28%, signal=24%","Cpt1a/Slc25a20"]
["DKO","DKO","Carbohydrate metabolism","Carbohydrate metabolism",419,-0.2745206395590417,-1.372941922642602,0.002263555884777895,0.1675031354735643,0.1644056379470261,3604,"tags=31%, list=24%, signal=24%","Abhd11/Pisd/Prps2/Glrx5/Acadvl/Foxk2/Ech1/Mthfsl/Cpt1c/Sfxn3/Iscu/Acad10/Taldo1/Slc25a19/Echdc1/Gldc/Prodh/Qdpr/Sdhc/Mocs1/Pdp1/Hint1/Sdha/Hibadh/Sphk2/Aldh1l1/Ndufs7/Cox10/Gcdh/Pdpr/Acaca/Gtpbp3/Dcxr/Nmnat3/Cpox/Osbpl1a/Sqor/Ptpmt1/Mpc2/Aldh9a1/Aldh7a1/Mpst/Ethe1/Aldh3a2/Cat/Stard7/Txnrd1/Fdps/Got2/Slc25a29/Tspo/Mgst3/Cox11/Slc25a10/Pgls/Acsf2/Acot7/Rfk/Fpgs/Rdh14/Coasy/Hagh/Acaa1a/Pdp2/D2hgdh/Gpd2/Mdh2/Chchd7/Aldh1b1/Mmab/Txnrd2/Suox/Spr/Lipt2/Amacr/Hmgcl/Pycr2/Sirt4/Gsr/Kmo/Coq8a/Mlycd/Bdh1/Rpia/Aldh4a1/Cyc1/Coq8b/Aldh2/Naxe/Foxk1/Coq2/Acly/Cyb5r3/Coq10a/Mthfd1l/Pfkl/Hk1/Ak4/H6pd/Lactb/Alas1/Pccb/Bckdk/Naxd/Abcb10/Acod1/Cmpk2/Eno2/Acads/Fdx1/Akr7a5/Acot2/Fxn/Acadl/Tkt/Eno3/Idi1/Zadh2/Shmt2/Fech/Eci1/Slc25a11/Plscr3/Acsf3/Iba57/Pank2/Ogdh/Slc25a1/Fasn/Fth1/Glud1"]
["DKO","DKO","Metabolism","Metabolism",403,-0.2686534076844563,-1.335576330451568,0.005860751945603718,0.2168478219873375,0.2128378338140298,3604,"tags=31%, list=24%, signal=24%","Abhd11/Pisd/Prps2/Glrx5/Acadvl/Ech1/Mthfsl/Cpt1c/Sfxn3/Iscu/Acad10/Taldo1/Slc25a19/Echdc1/Gldc/Prodh/Qdpr/Sdhc/Mocs1/Pdp1/Hint1/Sdha/Hibadh/Sphk2/Aldh1l1/Ndufs7/Cox10/Gcdh/Pdpr/Acaca/Gtpbp3/Dcxr/Nmnat3/Cpox/Osbpl1a/Sqor/Ptpmt1/Mpc2/Aldh9a1/Aldh7a1/Mpst/Ethe1/Aldh3a2/Cat/Stard7/Txnrd1/Fdps/Got2/Slc25a29/Tspo/Mgst3/Cox11/Slc25a10/Pgls/Acsf2/Acot7/Rfk/Fpgs/Rdh14/Coasy/Hagh/Acaa1a/Pdp2/D2hgdh/Gpd2/Mdh2/Chchd7/Aldh1b1/Mmab/Txnrd2/Suox/Spr/Lipt2/Amacr/Hmgcl/Pycr2/Sirt4/Gsr/Kmo/Coq8a/Mlycd/Bdh1/Rpia/Aldh4a1/Cyc1/Coq8b/Aldh2/Naxe/Coq2/Acly/Cyb5r3/Coq10a/Mthfd1l/Ak4/H6pd/Lactb/Alas1/Pccb/Bckdk/Naxd/Abcb10/Acod1/Cmpk2/Acads/Fdx1/Akr7a5/Acot2/Fxn/Acadl/Tkt/Idi1/Zadh2/Shmt2/Fech/Eci1/Slc25a11/Plscr3/Acsf3/Iba57/Pank2/Ogdh/Slc25a1/Fasn/Fth1/Glud1"]
["DKO","DKO","Gluconeogenesis","Gluconeogenesis",8,-0.7273389627202416,-1.700293049870545,0.01275844855386322,0.3147083976619596,0.3088887544619517,2640,"tags=62%, list=18%, signal=51%","Mpc2/Slc25a10/Mdh2/Slc25a11/Slc25a1"]
["DKO","DKO","TCA-associated","TCA-associated",13,-0.6127465494473952,-1.645444130490486,0.02760437342490141,0.4277724339844782,0.419861990681778,2640,"tags=54%, list=18%, signal=44%","Pcx/Abhd11/Mpc2/D2hgdh/Acly/Slc25a11/Slc25a1"]
["DKO","DKO","Lipid metabolism","Lipid metabolism",107,-0.327549772005928,-1.388744152317723,0.02890354283678907,0.4277724339844782,0.419861990681778,3685,"tags=35%, list=25%, signal=26%","Acad12/Acsl1/Hadha/Pisd/Acadvl/Ech1/Cpt1c/Acad10/Echdc1/Sphk2/Acaca/Osbpl1a/Ptpmt1/Stard7/Fdps/Tspo/Mgst3/Acsf2/Acot7/Acaa1a/Lipt2/Amacr/Mlycd/Cyb5r3/Lactb/Pccb/Acads/Fdx1/Acot2/Acadl/Idi1/Zadh2/Eci1/Plscr3/Acsf3/Slc25a1/Fasn"]
["DKO","DKO","Glycolysis","Glycolysis",16,-0.5297740824338372,-1.490244705467818,0.06999618266846058,0.5755241686073426,0.564881474166524,1019,"tags=31%, list=7%, signal=29%","Foxk1/Pfkl/Hk1/Eno2/Eno3"]
["DKO","DKO","Xenobiotic metabolism","Xenobiotic metabolism",13,-0.5461668102864523,-1.466653664659611,0.05162523900573614,0.5755241686073426,0.564881474166524,2485,"tags=38%, list=17%, signal=32%","Mpst/Aldh1b1/Aldh2/Cyb5r3/Akr7a5"]
["DKO","DKO","Detoxification","Detoxification",39,-0.4154852975298981,-1.447330260856628,0.05755395683453238,0.5755241686073426,0.564881474166524,2565,"tags=33%, list=17%, signal=28%","Aldh9a1/Aldh7a1/Mpst/Aldh3a2/Cat/Txnrd1/Hagh/Aldh1b1/Txnrd2/Gsr/Aldh2/Cyb5r3/Akr7a5"]
["DKO","DKO","Eicosanoid metabolism","Eicosanoid metabolism",3,-0.8102761428149955,-1.4067326639424,0.06719367588932806,0.5755241686073426,0.564881474166524,2173,"tags=100%, list=15%, signal=85%","Mgst3/Zadh2"]
["DKO","DKO","Heme synthesis and processing","Heme synthesis and processing",13,-0.507646088860529,-1.363211719487162,0.1147227533460803,0.7770817980840088,0.7627118644067797,799,"tags=46%, list=5%, signal=44%","Cox10/Cpox/Alas1/Abcb10/Fdx1/Fech"]
["DKO","DKO","Tetrahydobiopterin synthesis","Tetrahydobiopterin synthesis",3,-0.7649778715121817,-1.328089650166364,0.1422924901185771,0.7770817980840088,0.7627118644067797,3224,"tags=100%, list=22%, signal=78%","Qdpr/Spr"]
["DKO","DKO","GABA metabolism","GABA metabolism",5,-0.6584657631009241,-1.327978664862294,0.1482965931863728,0.7770817980840088,0.7627118644067797,575,"tags=60%, list=4%, signal=58%","Aldh9a1/Akr7a5/Glud1"]
["DKO","DKO","Vitamin D metabolism","Vitamin D metabolism",3,-0.7436989224767665,-1.291146944981326,0.1758893280632411,0.7770817980840088,0.7627118644067797,578,"tags=100%, list=4%, signal=96%","Fdxr/Fdx1"]
["DKO","DKO","Cholesterol-associated","Cholesterol-associated",2,-0.8451604132680804,-1.278624609877868,0.1387163561076604,0.7770817980840088,0.7627118644067797,2281,"tags=100%, list=16%, signal=85%","Idi1"]
["DKO","DKO","Iron homeostasis","Iron homeostasis",4,-0.683489074833439,-1.27815167525894,0.1806981519507187,0.7770817980840088,0.7627118644067797,24,"tags=50%, list=0%, signal=50%","Slc25a28/Fth1"]
["DKO","DKO","Selenoproteins","Selenoproteins",5,-0.6299071472850368,-1.270382302793452,0.1963927855711423,0.7770817980840088,0.7627118644067797,4846,"tags=80%, list=33%, signal=54%","Selenoo/Gpx1/Txnrd1/Txnrd2"]
["DKO","DKO","Pentose-Phosphate Shunt","Pentose-Phosphate Shunt",13,-0.4650877205390355,-1.248927245064568,0.1988527724665392,0.7770817980840088,0.7627118644067797,4065,"tags=54%, list=28%, signal=39%","Pgd/Prps2/Taldo1/Pgls/Rpia/H6pd/Tkt"]
["DKO","DKO","Coenzyme Q metabolism","Coenzyme Q metabolism",13,-0.4641090440294855,-1.246299147819891,0.2026768642447419,0.7770817980840088,0.7627118644067797,1290,"tags=31%, list=9%, signal=28%","Coq8a/Coq8b/Coq2/Coq10a"]
["DKO","DKO","Malate-aspartate shuttle","Malate-aspartate shuttle",6,-0.5778453843456441,-1.229009927798996,0.2298624754420432,0.7770817980840088,0.7627118644067797,2251,"tags=67%, list=15%, signal=56%","Got2/Slc25a10/Mdh2/Slc25a11"]
["DKO","DKO","Copper metabolism","Copper metabolism",6,-0.574109328256731,-1.221063771009516,0.237721021611002,0.7770817980840088,0.7627118644067797,6271,"tags=100%, list=43%, signal=57%","Slc25a3/Cox19/Cox17/Cox11/Chchd7"]
["DKO","DKO","Glycerol phosphate shuttle","Glycerol phosphate shuttle",1,-0.8788146537076055,-1.177068074455893,0.2318840579710145,0.7770817980840088,0.7627118644067797,1785,"tags=100%, list=12%, signal=88%"]
["DKO","DKO","Nucleotide synthesis and processing","Nucleotide synthesis and processing",21,0.3649137081752958,1.156648258371199,0.2415254237288136,0.7770817980840088,0.7627118644067797,1735,"tags=24%, list=12%, signal=21%","Paics/Ak3/Nudt5/Suclg1/Sucla2"]
["DKO","DKO","Metals and cofactors","Metals and cofactors",108,-0.2695012960292011,-1.141260031535419,0.2166123778501629,0.7770817980840088,0.7627118644067797,1742,"tags=19%, list=12%, signal=16%","Chchd7/Suox/Spr/Sirt4/Kmo/Coq8a/Cyc1/Coq8b/Naxe/Coq2/Coq10a/Alas1/Naxd/Abcb10/Fdx1/Fxn/Fech/Iba57/Pank2/Fth1"]
["DKO","DKO","Sulfur metabolism","Sulfur metabolism",11,-0.467275333165027,-1.186526842014461,0.2621359223300971,0.808252427184466,0.7933060807358202,2662,"tags=45%, list=18%, signal=37%","Sqor/Mpst/Ethe1/Got2/Suox"]
["DKO","DKO","ROS and glutathione metabolism","ROS and glutathione metabolism",24,-0.37143487089698,-1.161724931053746,0.2730627306273063,0.8082656826568266,0.7933190910856478,2565,"tags=33%, list=17%, signal=28%","Aldh9a1/Aldh7a1/Aldh3a2/Cat/Txnrd1/Hagh/Txnrd2/Gsr"]
["DKO","DKO","Cytochromes","Cytochromes",4,0.6323988029629676,1.187987191212374,0.3067961165048544,0.82862439747868,0.8133013289620045,5,"tags=25%, list=0%, signal=25%","mt-Cytb"]
["DKO","DKO","NAD biosynthesis and metabolism","NAD biosynthesis and metabolism",13,-0.4237503975993503,-1.137921715188248,0.3154875717017208,0.82862439747868,0.8133013289620045,1337,"tags=38%, list=9%, signal=35%","Nmnat3/Sirt4/Kmo/Naxe/Naxd"]
["DKO","DKO","Nucleotide metabolism","Nucleotide metabolism",31,0.3181720582313731,1.107256258849194,0.3021739130434782,0.82862439747868,0.8133013289620045,4510,"tags=39%, list=31%, signal=27%","Paics/Ak3/Nudt5/Suclg1/Sucla2/Nudt2/Slc25a5/Nme6/Ak2/Ppa2/Dhodh/Slc25a4"]
["DKO","DKO","Branched-chain amino acid metabolism","Branched-chain amino acid metabolism",25,0.3359512562935938,1.097752103427637,0.3247311827956989,0.82862439747868,0.8133013289620045,3862,"tags=40%, list=26%, signal=30%","Hsd17b10/Dbt/Hibch/Dld/Ppm1k/Acat1/Acad8/Etfdh/Auh/Etfb"]
["DKO","DKO","Heme-containing proteins","Heme-containing proteins",9,0.4603889503568946,1.098085945004337,0.348643006263048,0.8599860821155184,0.8440830677947478,5,"tags=11%, list=0%, signal=11%","mt-Cytb"]
["DKO","DKO","Glyoxylate metabolism","Glyoxylate metabolism",4,-0.6016889758548711,-1.125182246199255,0.3613963039014374,0.8626879512485925,0.8467349734872387,2251,"tags=75%, list=15%, signal=64%","Grhpr/Got2/Aldh4a1"]
["DKO","DKO","Amidoxime reducing complex","Amidoxime reducing complex",2,-0.7277003995143212,-1.100921937220256,0.3954451345755693,0.9144668737060041,0.8975563909774437,983,"tags=100%, list=7%, signal=93%","Cyb5r3"]
["DKO","DKO","Vitamin B1 metabolism","Vitamin B1 metabolism",1,-0.7735336097328893,-1.036056593610404,0.4368530020703933,0.964973850812001,0.9471293841540267,3334,"tags=100%, list=23%, signal=77%"]
["DKO","DKO","Branched-chain amino acid dehydrogenase complex","Branched-chain amino acid dehydrogenase complex",6,0.4604545085703064,0.9710358965174735,0.5212981744421906,0.964973850812001,0.9471293841540267,3015,"tags=50%, list=20%, signal=40%","Dbt/Dld/Ppm1k"]
["DKO","DKO","Vitamin B12 metabolism","Vitamin B12 metabolism",3,-0.5575224851021685,-0.9679232168318085,0.5632411067193676,0.964973850812001,0.9471293841540267,1686,"tags=67%, list=11%, signal=59%","Mmadhc/Mmab"]
["DKO","DKO","Vitamin B2 metabolism","Vitamin B2 metabolism",3,0.5642491449914442,0.9675352676855956,0.5504032258064516,0.964973850812001,0.9471293841540267,200,"tags=33%, list=1%, signal=33%","Slc25a32"]
["DKO","DKO","Catechol metabolism","Catechol metabolism",2,0.6292822185970637,0.9674285003480895,0.5722543352601156,0.964973850812001,0.9471293841540267,5456,"tags=100%, list=37%, signal=63%","Comt/Maoa"]
["DKO","DKO","TCA cycle","TCA cycle",20,0.3119774013105808,0.9613112915026868,0.509719222462203,0.964973850812001,0.9471293841540267,3301,"tags=45%, list=22%, signal=35%","Idh3b/Suclg1/Idh3a/Dld/Sucla2/Sdhb/Sdhd/Ogdhl/Mrps36"]
["DKO","DKO","Fe-S cluster biosynthesis","Fe-S cluster biosynthesis",22,-0.3027525901933935,-0.9317824161806048,0.5661764705882353,0.964973850812001,0.9471293841540267,578,"tags=14%, list=4%, signal=13%","Fdx1/Fxn/Iba57"]
["DKO","DKO","Electron carriers","Electron carriers",14,0.3333894540231861,0.9296284288721974,0.5135135135135135,0.964973850812001,0.9471293841540267,5,"tags=7%, list=0%, signal=7%","mt-Cytb"]
["DKO","DKO","Folate and 1-C metabolism","Folate and 1-C metabolism",21,-0.3026326950579097,-0.9134540429332745,0.5754716981132075,0.964973850812001,0.9471293841540267,3461,"tags=43%, list=24%, signal=33%","Mthfsl/Sfxn3/Qdpr/Aldh1l1/Gtpbp3/Aldh7a1/Fpgs/Mthfd1l/Shmt2"]
["DKO","DKO","Vitamin metabolism","Vitamin metabolism",46,-0.2512538984091463,-0.9131669142916282,0.5899653979238755,0.964973850812001,0.9471293841540267,3461,"tags=33%, list=24%, signal=25%","Mthfsl/Sfxn3/Slc25a19/Qdpr/Aldh1l1/Acaca/Gtpbp3/Aldh7a1/Rfk/Fpgs/Rdh14/Mmab/Mthfd1l/Fdx1/Shmt2"]
["DKO","DKO","Coenzyme A metabolism","Coenzyme A metabolism",4,-0.4857693580793266,-0.9084079639017738,0.6139630390143738,0.964973850812001,0.9471293841540267,2028,"tags=75%, list=14%, signal=65%","Slc25a42/Coasy/Pank2"]
["DKO","DKO","Kynurenine metabolism","Kynurenine metabolism",3,-0.5163455621820218,-0.8964353383029272,0.6225296442687747,0.964973850812001,0.9471293841540267,2251,"tags=67%, list=15%, signal=56%","Got2/Kmo"]
["DKO","DKO","Amino acid metabolism","Amino acid metabolism",68,0.213106765346588,0.8927217134146702,0.7025171624713958,0.964973850812001,0.9471293841540267,3586,"tags=34%, list=24%, signal=26%","Oat/Hsd17b10/Gpt2/Dbt/Hibch/Slc25a12/Gls/Aldh18a1/Dld/Kyat3/Gcat/Sfxn1/Acaa2/Abat/Comt/Ppm1k/Acat1/Hadhb/Acad8/Aldh5a1/Gcsh/Etfdh/Auh"]
["DKO","DKO","Propanoate metabolism","Propanoate metabolism",3,-0.5100559711572428,-0.8855158842182279,0.6383399209486166,0.964973850812001,0.9471293841540267,762,"tags=67%, list=5%, signal=63%","Mcee/Pccb"]
["DKO","DKO","Glycine cleavage system","Glycine cleavage system",4,0.4660132994487769,0.8754251717206086,0.629126213592233,0.964973850812001,0.9471293841540267,3408,"tags=50%, list=23%, signal=38%","Dld/Gcsh"]
["DKO","DKO","Creatine metabolism","Creatine metabolism",2,0.5657966286025014,0.869828779098887,0.6955684007707129,0.964973850812001,0.9471293841540267,6390,"tags=100%, list=43%, signal=57%","Gatm/Ckmt1"]
["DKO","DKO","Fatty acid oxidation","Fatty acid oxidation",40,-0.2478997661453907,-0.8680791096376685,0.6982142857142857,0.964973850812001,0.9471293841540267,4302,"tags=38%, list=29%, signal=27%","Acot11/Etfa/Acad12/Acsl1/Hadha/Acadvl/Cpt1c/Acad10/Acsf2/Acaa1a/Amacr/Pccb/Acads/Acadl/Eci1"]
["DKO","DKO","Glutamate metabolism","Glutamate metabolism",6,0.4089895583467756,0.8625033202273603,0.6450304259634888,0.964973850812001,0.9471293841540267,909,"tags=50%, list=6%, signal=47%","Gpt2/Slc25a12/Gls"]
["DKO","DKO","Serine metabolism","Serine metabolism",3,-0.4910421133381844,-0.8525056381449542,0.6699604743083004,0.964973850812001,0.9471293841540267,519,"tags=67%, list=4%, signal=64%","Sfxn3/Shmt2"]
["DKO","DKO","Vitamin B6 metabolism","Vitamin B6 metabolism",2,0.5487691433943951,0.8436515346245357,0.7302504816955684,0.964973850812001,0.9471293841540267,1715,"tags=50%, list=12%, signal=44%","Plpbp"]
["DKO","DKO","Proline metabolism","Proline metabolism",6,0.3871500499421147,0.816446769083866,0.6937119675456389,0.964973850812001,0.9471293841540267,1065,"tags=33%, list=7%, signal=31%","Oat/Aldh18a1"]
["DKO","DKO","Biotin utilizing proteins","Biotin utilizing proteins",5,0.401262686049965,0.8113684600825734,0.705765407554672,0.964973850812001,0.9471293841540267,2662,"tags=40%, list=18%, signal=33%","Pcca/Acacb"]
["DKO","DKO","Cardiolipin synthesis","Cardiolipin synthesis",16,0.2773700061894457,0.8007316386076025,0.7282377919320594,0.964973850812001,0.9471293841540267,681,"tags=12%, list=5%, signal=12%","Agpat5/Triap1"]
["DKO","DKO","Lysine metabolism","Lysine metabolism",13,0.2916514628739503,0.7937165705971294,0.7139874739039666,0.964973850812001,0.9471293841540267,3862,"tags=46%, list=26%, signal=34%","Dld/Acaa2/Acat1/Hadhb/Etfdh/Etfb"]
["DKO","DKO","Ketone metabolism","Ketone metabolism",6,-0.3546450209387381,-0.7542887135315016,0.7917485265225933,0.9875260521977168,0.9692645462538046,1415,"tags=33%, list=10%, signal=30%","Hmgcl/Bdh1"]
["DKO","DKO","Cholesterol, bile acid, steroid synthesis","Cholesterol, bile acid, steroid synthesis",10,-0.3010089815107372,-0.7472528026034364,0.8140417457305503,0.9875260521977168,0.9692645462538046,2683,"tags=30%, list=18%, signal=25%","Osbpl1a/Tspo/Fdx1"]
["DKO","DKO","Molybdenum cofactor synthesis and proteins","Molybdenum cofactor synthesis and proteins",3,0.4313483725614545,0.7396462481450835,0.8044354838709677,0.9875260521977168,0.9692645462538046,487,"tags=33%, list=3%, signal=32%","Abcb7"]
["DKO","DKO","Itaconate metabolism","Itaconate metabolism",6,0.3398195918516446,0.7166332740500894,0.8073022312373225,0.9875260521977168,0.9692645462538046,1735,"tags=33%, list=12%, signal=29%","Suclg1/Sucla2"]
["DKO","DKO","Nucleotide import","Nucleotide import",7,0.3260962501473522,0.7153522823368988,0.7995824634655533,0.9875260521977168,0.9692645462538046,4510,"tags=29%, list=31%, signal=20%","Slc25a5/Slc25a4"]
["DKO","DKO","Q-linked reactions, other","Q-linked reactions, other",10,-0.2821187710950901,-0.7003579803824677,0.8406072106261859,0.9904397705544934,0.9721243836167859,5053,"tags=50%, list=34%, signal=33%","Etfbkmt/Etfa/Prodh/Sqor/Gpd2"]
["DKO","DKO","Vitamin A metabolism","Vitamin A metabolism",4,-0.3718353500857255,-0.6953468506404178,0.8439425051334702,0.9904397705544934,0.9721243836167859,2042,"tags=75%, list=14%, signal=65%","Akr1b10/Dhrs4/Rdh14"]
["DKO","DKO","Type II fatty acid synthesis","Type II fatty acid synthesis",7,-0.3110342421655587,-0.6927290162850634,0.8565965583173997,0.9904397705544934,0.9721243836167859,283,"tags=29%, list=2%, signal=28%","Acaca/Acsf3"]
["DKO","DKO","Pyruvate metabolism","Pyruvate metabolism",13,0.2510332737831562,0.6831759635611742,0.872651356993737,0.993480006423639,0.9751083989079815,1681,"tags=23%, list=11%, signal=20%","Dld/Pdhb/Pdha1"]
["DKO","DKO","Phospholipid metabolism","Phospholipid metabolism",23,0.1979726322004211,0.636432797945198,0.9518599562363238,0.9940357852882704,0.9756539002118159,1632,"tags=13%, list=11%, signal=12%","Agpat5/Triap1/Prelid3b"]
["DKO","DKO","Lipoate insertion","Lipoate insertion",4,-0.3383091849921651,-0.6326515923588064,0.8891170431211499,0.9940357852882704,0.9756539002118159,1439,"tags=50%, list=10%, signal=45%","Lipt1/Lipt2"]
["DKO","DKO","Urea cycle","Urea cycle",3,0.351029841615118,0.6019216064170825,0.9435483870967742,0.9940357852882704,0.9756539002118159,9550,"tags=100%, list=65%, signal=35%","Slc25a13/Car5b/Slc25a15"]
["DKO","DKO","Fe-S-containing proteins","Fe-S-containing proteins",29,0.1753999247957833,0.5960524516597159,0.975609756097561,0.9940357852882704,0.9756539002118159,2968,"tags=21%, list=20%, signal=17%","Ndufs1/Isca1/Sdhb/Lias/Abat/Nthl1"]
["DKO","DKO","Vitamin C metabolism","Vitamin C metabolism",2,-0.3920609026644916,-0.5931403208762699,0.937888198757764,0.9940357852882704,0.9756539002118159,8947,"tags=100%, list=61%, signal=39%","Glrx2"]
["DKO","DKO","Glycine metabolism","Glycine metabolism",13,0.2044747260261983,0.5564689328695204,0.9582463465553236,0.9940357852882704,0.9756539002118159,3862,"tags=38%, list=26%, signal=28%","Dld/Gcat/Gcsh/Etfdh/Etfb"]
["DKO","DKO","Choline and betaine metabolism","Choline and betaine metabolism",6,-0.2355860756051129,-0.5010641836271876,0.9921414538310412,0.9940357852882704,0.9756539002118159,11250,"tags=50%, list=76%, signal=12%","Sardh/Etfa/Aldh7a1"]
["DKO","DKO","Carnitine synthesis and transport","Carnitine synthesis and transport",6,0.2341099021358241,0.4937059241963471,0.9918864097363083,0.9940357852882704,0.9756539002118159,5302,"tags=50%, list=36%, signal=32%","Slc25a20/Tmlhe/Cpt1b"]
["DKO","DKO","Carnitine shuttle","Carnitine shuttle",5,0.2330545924264056,0.4712452773359512,0.9940357852882704,0.9940357852882704,0.9756539002118159,11286,"tags=100%, list=77%, signal=23%","Slc25a20/Cpt1b/Cpt2/Cpt1a/Cpt1c"]