{"text_format":"3","workbook":"xlsx","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"read":"whole","date_system":"1900"}

{"sheet":"Sheet1","index":0,"n_rows":420,"n_cols":3,"rows_kept":420}
["Protein","δi GoF KRAS","δi after drug action"]
["ERKPP",5379,-0.04]
["AP1P",3367.56,-0.04]
["ERKPP_AP1",3281.68,-0.04]
["AP1P_Pase12",3281.68,-0.04]
["AP1P_TFBSII",3130.87,-0.04]
["ERBP_G_S_ERKPP",1824.03,-0.05]
["ERKP_MEKPP",1555.93,-0.04]
["ERKPP_Pase3",1555.93,-0.04]
["ERBP_G_GABP_ERKPP",1451.13,0.05]
["ERBP_ShP_G_GABP_ERKPP",1377.97,0.06]
["ERBP_ShP_G_S_ERKPP",753.3,-0.05]
["GABP_ERKPP",653.21,0.1]
["GABPP_PhoA",646.37,0.1]
["GABPP",645.78,0.1]
["ERB3P_G_S_ERKPP",468.51,-0.01]
["ERB3P_G_GABP_ERKPP",372.58,0.09]
["ERB3P_ShP_G_GABP_ERKPP",353.76,0.11]
["RP_G_S_ERKPP",259.89,0]
["RP_G_GABP_ERKPP",206.58,0.09]
["RP_ShP_G_GABP_ERKPP",196.12,0.11]
["ERB3P_Sh_G_S_ERKPP",193.05,-0.01]
["Ras_GTP_PKP_PIP2",170.88,191.07]
["Ras_GTP_PKP",166.8,192]
["Ras_GTP_PKP_PhoB",166.23,191.23]
["Ras_GTP_PK",120.63,131.66]
["Ras_GTP",118.95,133.52]
["RP_ShP_G_S_ERKPP",106.83,0]
["SOSP",100,-0.04]
["SOSP_Pase5",99.77,-0.04]
["G_S_ERKPP",99.52,-0.04]
["MEKPP",76.81,-0.02]
["Ras",59.3,66.63]
["Raf_Ras_GTP",44.89,9.43]
["ERBP_G_S_Ras_GTP",21.17,71.55]
["ERKP",19.01,-0.02]
["MEKP_Raf*",18.03,-0.01]
["MEKPP_Pase2",18.03,-0.01]
["CDC25CP_ERBP_ERBP",13.48,-0.06]
["PKP_PIP2",13.08,14.75]
["PKP",12.75,14.82]
["PKP_PhoB",12.7,14.76]
["ERBP_ShP_G_S_Ras_GTP",10.9,92.95]
["ERB_ERB",8.36,-0.05]
["SOS",5.32,-0.01]
["ERK_MEKPP",4.79,-0.02]
["ERKP_Pase3",4.79,-0.02]
["ERB3P_G_S_Ras_GTP",4.7,74.61]
["ERBP_G_S_Ras",3.77,14.63]
["Raf*",3.52,-0.01]
["MEKP",3.21,-0.01]
["CDC25CP",2.85,-0.03]
["ERBP_ERBP",2.76,-0.03]
["CDC25C_ERKPP",2.72,-0.03]
["CDC25CP_Pho16",2.72,-0.03]
["Raf*_Pase1",2.66,-0.01]
["CDC25CP_ERBP",2.47,-0.03]
["RP_G_S_Ras_GTP",2.17,74.92]
["ERB3P_Sh_G_S_Ras_GTP",2.06,96.91]
["EGF_ERB3P",1.8,0]
["EGF_ERB3_ERB",1.45,-0.02]
["ERB3_ERB",1.45,-0.02]
["TP53",1.38,-0.08]
["R_ERB",1.28,-0.02]
["Rl_ERB",1.28,-0.02]
["RlP_ERBP",1.27,-0.02]
["GSK",1.2,-0.09]
["ERB",1.18,-0.02]
["WNT_FRZ_LRP6P_DVL_GSK",1.07,-0.09]
["Raf**",0.97,0.11]
["ERBP_ERB",0.96,-0.02]
["WNT_FRZ_LRP6_DVL_GSK",0.88,-0.08]
["WNT_FRZ_LRP6P_DVL_GSK_PhoE",0.88,-0.08]
["EGF_ERB3P_ERBP",0.81,0]
["RP_ShP_G_S_Ras_GTP",0.7,97.31]
["RlP",0.61,-0.01]
["Raf**_Pase1",0.6,0.11]
["Raf*_AKTP",0.6,0.11]
["TP53_TFBSIV",0.54,-0.05]
["APCP",0.48,-0.04]
["AXNP_GSK_APCP",0.34,-0.04]
["APCP_PhoE",0.34,-0.04]
["AXNP_GSK_APC",0.34,-0.04]
["ERBP_ShP_G_GAB",0.34,-0.03]
["AXNP_GSK",0.34,-0.04]
["EGF_ERB3_ERB3",0.27,0]
["ERB3_ERB3",0.27,0]
["ERB3P_G_S_Ras",0.23,15.29]
["AXNP_GSK_PhoE",0.22,-0.03]
["Cadh",0.21,-0.03]
["AXNP",0.21,-0.03]
["Cadh_PTP",0.18,-0.02]
["EGF_ERB3_R",0.18,0]
["R_ERB3",0.18,0]
["MDM2",0.18,-0.02]
["Rl_ERB3",0.17,0]
["RlP_ERB3P",0.17,0]
["AXN_GSK",0.16,-0.03]
["Grb",0.14,0]
["ERBP_ShP_G",0.14,-0.01]
["AKT",0.13,-0.02]
["EGF_ERB3",0.13,0]
["ERB3",0.13,0]
["AXNP_PhoE",0.1,-0.02]
["CDC25CP_RP_RP",0.1,0]
["R_R",0.1,-0.01]
["Rl_R",0.09,0]
["RlP_RP",0.09,0]
["Shc",0.09,0]
["PKC",0.09,-0.31]
["Rl2P",0.09,0]
["Rl2",0.09,0]
["GAB",0.09,-0.02]
["WNT_FRZ_LRP6P_DVL_GSK_AXN",0.09,-0.02]
["PTP1E",0.08,0]
["R",0.05,0]
["Rl",0.04,0]
["RP_ERBP",0.04,-0.01]
["GROUCHO_TCFLEF_TFBS",0.04,0]
["SMAD4_TCFLEF_TFBS",0.04,0]
["TAKT",0.03,-0.01]
["MEKP_Pase2",0.03,0]
["MEK_Raf*",0.03,0]
["TFBS",0.03,0]
["ERBP_ShP",0.03,-0.01]
["PaseX",0.03,0]
["PIP2",0.02,0]
["ARF_MDM2",0.02,0]
["PhoC",0.02,0]
["PLCy",0.02,0]
["EGF_ERB3_ERBP",0.02,0]
["ERB3_ERBP",0.02,0]
["ERB3P_ERBP",0.02,0]
["BetaCateninP",0.01,0]
["PI3K",0.01,-0.01]
["PTEN",0.01,0]
["TCFLEF",0.01,0]
["GROUCHO_TCFLEF",0.01,0]
["SMAD4_TCFLEF",0.01,0]
["AXNP_GSK_APCP_BetaCatenin",0.01,0]
["AXNP_GSK_BetaCatenin",0,0]
["GAP",0,0]
["PDK1",0,0]
["APC",0,0]
["TAK",0,0]
["DIMTGF_DIMTBRII_DIMTBRIP_TAK",0,0]
["PhoA",0,0]
["Pase9",0,0]
["Pho13",0,0]
["Pase8",0,0]
["TFBSI",0,0]
["PTP",0,0]
["NLK",0,0]
["SMADII",0,0]
["SMADIIP",0,0]
["SMADIIP_PP1A",0,0]
["SMADIII",0,0]
["SMADIIIP",0,0]
["DIMTGF_DIMTBRII_DIMTBRIP_SMADII",0,0]
["SMADIIIP_PP1A",0,0]
["DIMTGF_DIMTBRII_DIMTBRIP_SMADIII",0,0]
["Pase10",0,0]
["TAB",0,0]
["DIMTGF_DIMTBRII",0,0]
["DIMTGF",0,0]
["DIMTBRII",0,0]
["TBRII",0,0]
["E2F_DP1_RB_TFBSV",0,0]
["TFBSV",0,0]
["E2F_DP1_TFBSV",0,0]
["RB",0,0]
["RBP_Pho14",0,0]
["CYCLIND1_CDK4_RB",0,0]
["RBP",0,0]
["CYCLINE_CDK2_RBP",0,0]
["RBPP_Pho14",0,0]
["RBPP",0,0]
["E2F_DP1_RB",0,0]
["PP1C",0,0]
["Pho14",0,0]
["P16",0,0]
["TGF",0,0]
["PIP2_generator",0,0]
["GDP",0,0]
["GTP",0,0]
["TP53_generator",0,0]
["WNT",0,0]
["EGF",0,0]
["BetaCatenin_generator",0,0]
["CDK2",0,0]
["CYCLINE",0,0]
["CYCLINE_CDK2",0,0]
["CDK4",0,0]
["CYCLIND1",0,0]
["CYCLIND1_CDK4_P16",0,0]
["CYCLIND1_CDK4",0,0]
["DP1",0,0]
["E2F",0,0]
["E2F_DP1",0,0]
["PP1A",0,0]
["TBRI",0,0]
["DIMTGF_DIMTBRII_DIMTBRIP",0,0]
["DIMTBRIP_PP1C",0,0]
["DIMTBRIP",0,0]
["DIMTGF_DIMTBRII_DIMTBRI",0,0]
["DIMTBRI",0,0]
["GROUCHO",0,0]
["SMADIIP_SMAD4_TFBSI",0,0]
["SMADIIIP_SMAD4_TFBSI",0,0]
["SMADIIP_SMAD4",0,0]
["SMADIIIP_SMAD4",0,0]
["SMAD4",0,0]
["Pase5",0,0]
["PhoB",0,0]
["TP53U",-0.01,0]
["MDM2P_TP53",-0.01,0]
["ERBP_Sh",-0.02,-0.01]
["Pase12",-0.03,0]
["ERBP_G",-0.03,0]
["ERBP_G_GAB",-0.03,-0.01]
["Pho16",-0.03,0]
["FRZ",-0.05,0]
["WNT_FRZ",-0.05,0]
["LRP6",-0.05,0]
["DVL",-0.05,0]
["R_ERBP",-0.06,0]
["ERBP_PKP_PIP2",-0.06,-0.01]
["TCFLEFP_Pase8",-0.07,0.01]
["NLKP_TCFLEF",-0.07,0.01]
["TCFLEFP",-0.07,0.01]
["BetaCatenin_Cadh",-0.07,0.01]
["TFBSII",-0.07,0]
["BetaCatenin_Cadh_PTP",-0.07,0.01]
["BetaCateninP_PhoE",-0.08,0.01]
["TAKP_Pase9",-0.08,0.01]
["NLKP_Pase10",-0.08,0.01]
["TAKP_TAB_NLK",-0.08,0.01]
["NLKP",-0.08,0.01]
["TAKP_TAB",-0.08,0.01]
["TAKP",-0.08,0.01]
["ERBP_PKP",-0.08,-0.01]
["ERBP_PKP_PhoB",-0.08,-0.01]
["ERBP_PL",-0.08,0]
["ERBP_PLP",-0.08,0]
["ERBP_PK",-0.09,-0.02]
["PhoE",-0.09,0.01]
["ERBP_GAP",-0.1,0]
["WNT_FRZ_LRP6_TAK",-0.1,0.01]
["WNT_FRZ_LRP6",-0.1,0.01]
["ERBP",-0.1,0]
["CDC25CP_ERB3P",-0.11,0.01]
["ARF",-0.13,0.02]
["WNT_FRZ_LRP6_DVL",-0.14,0.01]
["BetaCatenin_Cadh_ERBP",-0.16,0.01]
["Pase1",-0.19,0]
["TCFLEF_BetaCatenin_TFBS",-0.22,0.03]
["GSKP_PhoC",-0.22,0.02]
["AKTP_GSK",-0.22,0.02]
["GSKP",-0.23,0.02]
["TCFLEF_BetaCatenin",-0.24,0.04]
["APC_BetaCatenin",-0.25,0.04]
["BetaCatenin",-0.25,0.04]
["RP_ERB3P",-0.27,0.02]
["RP_G_S_Ras",-0.32,15.35]
["TFBSIV",-0.35,0.03]
["AP1",-0.39,0]
["AP1_TFBSII",-0.43,0]
["AXN",-0.48,0.07]
["EGF_ERB3P_RP",-0.48,0.03]
["DAG_PKC",-0.49,1.83]
["ERB3P_ERB",-0.49,0.02]
["CDC25CP_RP",-0.5,0.02]
["ERBP_ShP_G_GAB_PIP3",-0.58,0.11]
["AKTP_MDM2",-0.58,0.09]
["MDM2P_Pho13",-0.58,0.09]
["MDM2P",-0.58,0.09]
["Raf",-0.62,-0.92]
["AKTP_TAKT",-0.63,0.11]
["AKT_PIP3_PDK1",-0.63,0.11]
["AKT_PIP3",-0.64,0.11]
["AKTP",-0.65,0.12]
["GAB_PIP3",-0.65,0.12]
["ERB3P_ShP_G_GAB",-0.66,0.01]
["ERBP_G_S",-0.66,-0.01]
["PIP3_PTEN",-0.67,0.14]
["PIP3",-0.68,0.14]
["ERBP_G_GAB_PIP3",-0.68,0.12]
["ERB3P_ShP_G",-0.71,0.03]
["Pase3",-0.71,0]
["ERBP_G_GABP_PKP_PIP2",-0.71,0.1]
["ERBP_G_S_Ras_GDP",-0.71,-0.06]
["RP_RP",-0.71,0.03]
["ERBP_G_GABP_PKP",-0.72,0.1]
["RP_ERB",-0.72,0.03]
["ERBP_G_GABP_PKP_PhoB",-0.72,0.1]
["ERBP_G_GABP_PK",-0.73,0.07]
["ERBP_ShP_G_GABP_PKP_PIP2",-0.73,0.11]
["ERBP_G_GABP_GAP",-0.73,0.08]
["ERBP_G_GABP_PhoA",-0.73,0.08]
["ERBP_G_GABP",-0.73,0.08]
["ERBP_ShP_G_GABP_PKP",-0.73,0.12]
["ERBP_ShP_G_GABP_PKP_PhoB",-0.73,0.11]
["ERB3P_ShP",-0.74,0.04]
["ERB3P_ERB3",-0.74,0.04]
["ERBP_ShP_G_GABP_PK",-0.74,0.09]
["ShP_G_S",-0.74,0.03]
["ERBP_ShP_G_GABP_GAP",-0.74,0.1]
["ERBP_ShP_G_GABP_PhoA",-0.74,0.1]
["ERBP_ShP_G_GABP",-0.74,0.1]
["ERB3P_Sh",-0.75,0.03]
["PTP1E_ShP",-0.75,0.03]
["ERB3P_G",-0.75,0.04]
["ERB3P_G_GAB",-0.75,0.03]
["Pase2",-0.76,0]
["Rl_ERB3P",-0.76,0.04]
["R_ERB3P",-0.76,0.04]
["ERB3P_PKP_PIP2",-0.76,0.03]
["ERB3P_PKP",-0.76,0.03]
["ERB3P_PKP_PhoB",-0.76,0.03]
["ERB3P_PL",-0.76,0.04]
["ERB3P_PLP",-0.76,0.04]
["ERB3P_PK",-0.76,0.03]
["PLCyP_PaseX",-0.77,0.04]
["IP3",-0.77,0.03]
["PIP2_PLCyP",-0.77,0.03]
["DAG",-0.77,0.03]
["ShP",-0.77,0.04]
["ERB3P_GAP",-0.77,0.04]
["ERB3P",-0.77,0.04]
["PLCyP",-0.77,0.04]
["MEK",-0.77,0]
["BetaCateninY654_Cadh_PTP",-0.79,0.05]
["DAG_PKC_Raf",-0.81,-0.78]
["RP_ShP_G_GAB",-0.81,0.02]
["TCFLEF_BetaCateninY654_TFBS",-0.81,0.07]
["TCFLEF_BetaCateninY654",-0.82,0.07]
["BetaCateninY654",-0.82,0.07]
["RP_ShP_G",-0.84,0.04]
["RP_ShP",-0.85,0.04]
["EGF_ERB3_RP",-0.85,0.05]
["RP_ERB3",-0.85,0.05]
["RP_Sh",-0.86,0.04]
["ERBP_ShP_G_S",-0.86,-0.01]
["RP_G",-0.86,0.04]
["RP_G_GAB",-0.86,0.03]
["RP_R",-0.87,0.04]
["RP_PKP_PIP2",-0.87,0.03]
["RP_PKP",-0.87,0.04]
["RP_PKP_PhoB",-0.87,0.03]
["RP_PL",-0.87,0.04]
["RP_PLP",-0.87,0.04]
["RP_PK",-0.87,0.03]
["RP_GAP",-0.87,0.04]
["RP",-0.87,0.04]
["GABP_PhoA",-0.88,0.14]
["GABP",-0.88,0.14]
["BetaCatenin_Cadh_RP",-0.88,0.05]
["ERBP_ShP_G_S_Ras",-0.88,-0.05]
["ERB3P_ShP_G_GAB_PIP3",-0.89,0.16]
["ShP_G",-0.9,0.03]
["ERBP_G_GABP_PKP_PIP3",-0.91,0.25]
["ERB3P_G_S",-0.91,0.03]
["ERBP_ShP_G_GABP_PKP_PIP3",-0.91,0.27]
["CDC25CP_ERB3P_ERB3P",-0.92,0.07]
["ERB3P_G_GAB_PIP3",-0.92,0.17]
["ERK",-0.93,0]
["ERB3P_G_GABP_PKP_PIP2",-0.93,0.14]
["ERB3P_G_S_Ras_GDP",-0.93,-0.02]
["ERBP_ShP_G_S_Ras_GDP",-0.93,-0.42]
["ERB3P_G_GABP_PKP",-0.93,0.15]
["ERB3P_G_GABP_PKP_PhoB",-0.93,0.14]
["ERB3P_G_GABP_PK",-0.93,0.11]
["ERB3P_ShP_G_GABP_PKP_PIP2",-0.93,0.16]
["ERB3P_G_GABP_GAP",-0.93,0.13]
["ERB3P_G_GABP_PhoA",-0.93,0.13]
["ERB3P_G_GABP",-0.93,0.13]
["ERB3P_ShP_G_GABP_PKP",-0.93,0.17]
["ERB3P_ShP_G_GABP_PKP_PhoB",-0.93,0.16]
["ERB3P_ShP_G_GABP_PK",-0.93,0.13]
["ERB3P_ShP_G_GABP_GAP",-0.93,0.15]
["ERB3P_ShP_G_GABP_PhoA",-0.93,0.15]
["ERB3P_ShP_G_GABP",-0.93,0.15]
["RP_ShP_G_GAB_PIP3",-0.94,0.16]
["RP_G_S",-0.95,0.04]
["RP_G_GAB_PIP3",-0.95,0.17]
["RP_G_GABP_PKP_PIP2",-0.96,0.15]
["RP_G_S_Ras_GDP",-0.96,-0.02]
["RP_G_GABP_PKP",-0.96,0.15]
["RP_G_GABP_PKP_PhoB",-0.96,0.15]
["GABP_PIP3",-0.96,0.3]
["RP_G_GABP_PK",-0.96,0.12]
["RP_ShP_G_GABP_PKP_PIP2",-0.96,0.17]
["RP_G_GABP_GAP",-0.96,0.13]
["RP_G_GABP_PhoA",-0.96,0.13]
["RP_G_GABP",-0.96,0.13]
["RP_ShP_G_GABP_PKP",-0.96,0.17]
["RP_ShP_G_GABP_PKP_PhoB",-0.96,0.17]
["RP_ShP_G_GABP_PK",-0.96,0.14]
["RP_ShP_G_GABP_GAP",-0.96,0.15]
["RP_ShP_G_GABP_PhoA",-0.96,0.15]
["RP_ShP_G_GABP",-0.96,0.15]
["ERB3P_ShP_G_S",-0.96,0.03]
["ERB3P_Sh_G_S_Ras",-0.97,-0.01]
["ERB3P_ERB3P",-0.98,0.1]
["Ras_GDP",-0.98,-0.98]
["RP_ShP_G_S",-0.98,0.03]
["ERB3P_Sh_G_S_Ras_GDP",-0.98,-0.4]
["G_S",-0.98,-0.01]
["RP_ShP_G_S_Ras",-0.98,-0.01]
["RP_ShP_G_S_Ras_GDP",-0.99,-0.4]
["CDC25C",-1,0.01]
["RP_GAP_Ras_GTP",-1,-1]
["RP_G_GABP_GAP_Ras_GTP",-1,-1]
["RP_ShP_G_GABP_GAP_Ras_GTP",-1,-1]
["ERBP_GAP_Ras_GTP",-1,-1]
["ERBP_G_GABP_GAP_Ras_GTP",-1,-1]
["ERBP_ShP_G_GABP_GAP_Ras_GTP",-1,-1]
["ERB3P_GAP_Ras_GTP",-1,-1]
["ERB3P_G_GABP_GAP_Ras_GTP",-1,-1]
["ERB3P_ShP_G_GABP_GAP_Ras_GTP",-1,-1]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0}

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0}