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["Rule 57 Aquatic Values Data Sheet"]
[]
["Chemical or product name:  Imidacloprid",null,null,"Developed by:   Sara Nedrich",null,null,"FAV*: ","0.72 ug/L",null,null,"(Tier: II)"]
["Manufacturer (WTAs):  -----",null,null,"Approved by: ",null,"Dennis Bush","AMV*:   ","0.36 ug/L",null,null,"(Tier: II)"]
["C.A.S #:  138261-41-3",null,null,"Approval date: ",null,"2021-12-29","FCV*:    ","0.029 ug/L",null,null,"(Tier: II)"]
[{"$nulls":3},"CAS, AQUIRE, QSAR: ",null,null,"      Acute CF: 4.3",null," Chronic CF: ----"]
[{"$nulls":3},"Literature Search Date: August 25, 2021"]
[]
[]
[{"$nulls":4},"ACUTE DATA 1"]
[]
[null,"Endpoint","Duration","Test Type","Hardness","Test","LC50/EC50","SMAV","GMAV"]
["Species","(EC or LC50)","(hours)","(FT,M, etc.)","mg/L","Chemical","ug/L","ug/L","ug/L","Rank","Reference"]
["Mayfly","EC50",96,"S, M"," -----","reagent grade",3.11,3.11,3.11,1,1]
["Neocloeon triangulifer"]
[]
["Bloodworm / Midge","EC50",96,"S, M"," -----","reagent grade",2.47,{"v":4.036285982355383,"d":"4.04"},{"v":4.036285982355383,"d":"4.04"},2,1]
["Chironomus dilutus","LC50",96,"S, M",111,"reagent grade",4.63,{"$nulls":3},2]
[null,"LC50",96,"S, M",140,"reagent grade",5.75,{"$nulls":3},3]
[]
["Casemaker Caddisfly","EC50",96,"S, M"," -----","reagent grade",6.4,6.4,6.4,3,4]
["Micrasema sp."]
[]
["Spiny-crawler Mayfly","EC50",96,"S, M"," -----","reagent grade",10.6,10.6,10.6,4,4]
["Ephemerella sp."]
[]
["Flat-headed Mayfly","EC50",96,"S, M"," -----","reagent grade",10.6,10.6,10.6,5,4]
["McCaffertium sp."]
[]
["Mayfly","EC50",96,"S, Ua"," -----","reagent grade",18,18,{"v":20.391174561559716,"d":"20.4"},6,5]
["Cloeon dipterum"]
[]
["Mayfly","EC50",96,"S, M"," -----","reagent grade",23.1,23.1,null,null,4]
["Cloeon sp."]
[]
["Oligocheate","EC50",96,"S, M"," -----","reagent grade",32.4,32.4,32.4,7,1]
["Lumbriculus variegatus"]
[]
["Amphipod / Freshwater Scud","EC50",96,"S, Ua"," -----","reagent grade",33.5,33.5,33.5,8,6]
["Hyalella azteca"]
[]
["Whirligig Beetle","EC50",96,"S, M"," -----","reagent grade",57.5,57.5,57.5,9,4]
["Gyrinus sp."]
[]
["Brush-legged Mayfly / Mahogany Dun","EC50",96,"S, U"," -----","reagent grade","5.8b",60.4,60.4,10,7]
["Isonychia bicolor","EC50",96,"S, M"," -----","reagent grade",60.4,{"$nulls":3},4]
[]
["Riffle Beetle","EC50",96,"S, M"," -----","reagent grade",99.2,99.2,99.2,11,4]
["Stenelmis sp. "]
[]
["Isopod","EC50",96,"S, M"," -----","reagent grade",320.8,320.8,320.8,12,4]
["Caecidotea sp."]
[]
["Burrower Mayfly","LC50",96,"S, Ua"," -----","reagent grade",900,900,900,13,8]
["Hexagenia sp."]
[]
["Northwestern Salamander","LC50",96,"S, U"," -----","reagent grade",">6750",6750,6750,14,9]
["Ambystoma gracile"]
[]
["Water Flea","EC50",48,"S, Ua",250,"reagent grade",16500,{"v":62568.71456942897,"d":"62568.7"},{"v":62568.71456942897,"d":"62568.7"},15,10]
["Daphnia magna","EC50",48,"S, U"," -----","reagent grade",93880,{"$nulls":3},11]
[null,"EC50",48,"S, U"," -----","reagent grade",97000,{"$nulls":3},12]
[null,"EC50",48,"S, Md",null,"reagent grade",102000,{"$nulls":3},15]
[]
["Rainbow trout","EC50",96,"FT, M",230,"reagent grade",211000,211000,211000,16,13]
["Oncorhynchus mykiss"]
[]
["CHRONIC DATA 5"]
[]
[{"$nulls":3},"Study"]
[null,"Test type","Duration","Conditions","Hardness","Test","MATC ","SMCV","GMCV",null,null,"LC/EC50 of paired study","Species ACR"]
["Species","(ELS, etc.)","(days)","(FT,M etc.)","mg/L","Chemical","ug/L","ug/L","ug/L","Rank","Most Sensitive Endpoint",null,null,"Reference(s)"]
["Bloodworm / Midge","FLC",56,"S, M"," -----","reagent grade",0.13,0.13,0.13,1,"emergence",2.47,{"v":19,"d":"19.0"},"1, 14"]
["Chironomus dilutus"]
[]
["Mayfly","ELS*",32,"S, M"," -----","reagent grade",1.49,1.49,1.49,2,"emergence",3.11,"2.1c","1, 14"]
["Neocloeon triangulifer"]
[]
["Water Flea","FLC",21,"S, M"," -----","reagent grade",2163.75,{"v":2163.75,"d":"2164"},{"v":2163.75,"d":"2164"},3,"reproduction",102000,{"v":47.14038128249567,"d":"47.1"},"4, 15"]
["Daphnia magna","FLC",21,"S, Ua"," -----","reagent grade","2828.43b",{"$nulls":4},97000,null,"12, 16"]
[]
[{"$nulls":11},"geomean ACR:",{"v":25.26231031848873,"d":"25.3"}]
["FLC=Full life cycle (larval through reproduction)",{"$nulls":10},"FCV:",{"v":0.028500956204035442,"d":"0.0285"}]
["*Larval through emergence (no reproduction)"]
[]
["a - study used unmeasured concentrations in their LC/EC50 derivation, but tested a few chambers and verified that measured and unmeasured concentrations were not statistically different"]
["b - measured tests are prefered to unmeasured tests"]
["c - mayfly ACR not used in final FCV calculation due to observed discrepancies with other mayfly data and unusually low value (> magnitude 10 difference from other available ACRs)"]
["d - organisms fed, but study included based on best professional judgement"]

{"sheet":"Imidacloprid References","index":1,"n_rows":17,"n_cols":2,"rows_kept":17,"flags":["formulas_cached_only"]}
["Ref No","Citation"]
[1,"Raby, M., Maloney, E., Poirier, D.G., Sibley, P.K., 2019. Acute effects of binary mixtures of imidacloprid and tebuconazole on 4 freshwater invertebrates. Environ. Toxicol. Chem. 38, 1093–1103. https://doi.org/10.1002/etc.4386"]
[2,"Maloney, E.M., Morrissey, C.A., Headley, J. V., Peru, K.M., Liber, K., 2017. Cumulative toxicity of neonicotinoid insecticide mixtures to Chironomus dilutus under acute exposure scenarios. Environ. Toxicol. Chem. 36, 3091–3101. https://doi.org/10.1002/etc.3878"]
[3,"Stoughton, S.J., Liber, K., Culp, J., Cessna, A., 2008. Acute and chronic toxicity of imidacloprid to the aquatic invertebrates Chironomus tentans and Hyalella azteca under constant- and pulse-exposure conditions. Arch. Environ. Contam. Toxicol. 54, 662–673. https://doi.org/10.1007/s00244-007-9073-6"]
[4,"Raby, M., Nowierski, M., Perlov, D., Zhao, X., Hao, C., Poirier, D.G., Sibley, P.K., 2018. Acute toxicity of 6 neonicotinoid insecticides to freshwater invertebrates. Environ. Toxicol. Chem. 37, 1430–1445. https://doi.org/10.1002/etc.4088"]
[5,"Van den Brink, P.J., Van Smeden, J.M., Bekele, R.S., Dierick, W., De Gelder, D.M., Noteboom, M., Roessink, I., 2016. Acute and chronic toxicity of neonicotinoids to nymphs of a mayfly species and some notes on seasonal differences. Environ. Toxicol. Chem. 35, 128–133. https://doi.org/10.1002/etc.3152"]
[6,"Lanteigne, M., Whiting, S.A., Lydy, M.J., 2015. Mixture Toxicity of Imidacloprid and Cyfluthrin to Two Non-target Species, the Fathead Minnow Pimephales promelas and the Amphipod Hyalella azteca. Arch. Environ. Contam. Toxicol. 68, 354–361. https://doi.org/10.1007/s00244-014-0086-7"]
[7,"Camp, A.A., Buchwalter, D.B., 2016. Can’t take the heat: Temperature-enhanced toxicity in the mayfly Isonychia bicolor exposed to the neonicotinoid insecticide imidacloprid. Aquat. Toxicol. 178, 49–57. https://doi.org/10.1016/j.aquatox.2016.07.011"]
[8,"Bartlett, A.J., Hedges, A.M., Intini, K.D., Brown, L.R., Maisonneuve, F.J., Robinson, S.A., Gillis, P.L., de Solla, S.R., 2018. Lethal and sublethal toxicity of neonicotinoid and butenolide insecticides to the mayfly, Hexagenia spp. Environ. Pollut. 238, 63–75. https://doi.org/10.1016/j.envpol.2018.03.004"]
[9,"Danis, B.E.G., Marlatt, V.L., 2021. Investigating Acute and Subchronic Effects of Neonicotinoids on Northwestern Salamander Larvae. Arch. Environ. Contam. Toxicol. 80, 691–707. https://doi.org/10.1007/s00244-021-00840-4"]
[10,"Qi, S., Wang, D., Zhu, L., Teng, M., Wang, C., Xue, X., Wu, L., 2018. Neonicotinoid insecticides imidacloprid, guadipyr, and cycloxaprid induce acute oxidative stress in Daphnia magna. Ecotoxicol. Environ. Saf. 148, 352–358. https://doi.org/10.1016/j.ecoenv.2017.10.042"]
[11,"Chevalier, J., Harscoët, E., Keller, M., Pandard, P., Cachot, J., Grote, M., 2015. Exploration of Daphnia behavioral effect profiles induced by a broad range of toxicants with different modes of action. Environ. Toxicol. Chem. 34, 1760–1769. https://doi.org/10.1002/etc.2979"]
[12,"Loureiro, S., Svendsen, C., Ferreira, A.L.G., Pinheiro, C., Ribeiro, F., Soares, A.M.V.M., 2010. Toxicity of three binary mixtures to daphnia magna: Comparing chemical modes of action and deviations from conceptual models. Environ. Toxicol. Chem. 29, 1716–1726. https://doi.org/10.1002/etc.198"]
[13,"Grau, R., 1988. Acute toxicity of NTN 33893 technical to rainbow trout (Salmo gairdneri). Kansas City, Missouri."]
[14,"Raby, M., Zhao, X., Hao, C., Poirier, D.G., Sibley, P.K., 2018. Chronic toxicity of 6 neonicotinoid insecticides to Chironomus dilutus and Neocloeon triangulifer. Environ. Toxicol. Chem. 37, 2727–2739. https://doi.org/10.1002/etc.4234"]
[15,"Raby, M., Zhao, X., Hao, C., Poirier, D.G., Sibley, P.K., 2018. Relative chronic sensitivity of neonicotinoid insecticides to Ceriodaphnia dubia and Daphnia magna. Ecotoxicol. Environ. Saf. 163, 238–244. https://doi.org/10.1016/j.ecoenv.2018.07.086"]
[16,"Pavlaki, M.D., Pereira, R., Loureiro, S., Soares, A.M.V.M., 2011. Effects of binary mixtures on the life traits of Daphnia magna. Ecotoxicol. Environ. Saf. 74, 99–110. https://doi.org/10.1016/j.ecoenv.2010.07.010"]

{"sheet":"Clothianidin","index":2,"n_rows":87,"n_cols":14,"rows_kept":87,"merged":[[69,11,70,11],[69,12,70,12]],"flags":["formulas_cached_only"]}
["Rule 57 Aquatic Values Data Sheet"]
[{"$nulls":8},"unit"]
["Chemical or product name:  Clothianidin",null,null,"Developed by:   Sara Nedrich",null,null,"FAV*: ",{"v":0.5832528466969513,"d":"0.58"},"ug/L",null,"(Tier: II)"]
["Manufacturer (WTAs):  -----",null,null,"Approved by: ",null,"Kevin Cox","AMV*:   ",{"v":0.29162642334847566,"d":"0.29"},"ug/L",null,"(Tier: II)"]
["C.A.S #: 210880-92-5",null,null,"Approval date: ",null,"2023-10-09","FCV*:    ",{"v":0.08126699726187643,"d":"0.081"},"ug/L",null,"(Tier: II)"]
[{"$nulls":3},"CAS, AQUIRE, QSAR: ",null,null,"      Acute CF:",4.3," Chronic CF: ----"]
[{"$nulls":3},"Literature Search Date: December 13, 2021"]
[]
[]
[{"$nulls":4},"ACUTE DATA 1"]
[]
[null,"Endpoint","Duration","Test Type","Hardness","Test","LC50/EC50","SMAV","GMAV"]
["Species","(EC or LC50)","(hours)","(FT,M, etc.)","mg/L","Chemical","ug/L","ug/L","ug/L","Rank","Reference","Tier 1 Req Met? (7)"]
["Bloodworm / Midge","EC50a",96,"S, M",100,"reagent grade",1.85,{"v":2.5079872407968904,"d":"2.5"},{"v":2.5079872407968904,"d":"2.5"},1,1]
["Chironomus dilutus","EC50",96,"S, M"," -----","reagent grade",3.4,{"$nulls":3},2]
[null,"LC50a,b",96,"S, M",111,"reagent grade",5.93,{"$nulls":3},3]
[]
["Mayfly","EC50",96,"S, M"," -----","reagent grade",3.5,3.5,3.5,2,2,"vi"]
["Neocloeon triangulifer"]
[]
["Burrower Mayfly","EC50",96,"S, M"," -----","reagent grade",5.5,5.5,5.5,3,2]
["Hexagenia sp."]
[]
["Amphipod / Freshwater Scud","EC50",96,"S, M"," -----","reagent grade",4.8,{"v":5.658268286322238,"d":"5.7"},{"v":5.658268286322238,"d":"5.7"},4,2,"v"]
["Hyalella azteca","EC50",96,"S, M",100,"reagent grade",6.67,{"$nulls":3},1]
[]
["Mayfly","EC50",96,"S, M"," -----","reagent grade","<16.4",16.4,16.4,5,2]
["Cloeon sp."]
[]
["Spiny-crawler Mayfly","EC50",96,"S, M"," -----","reagent grade",18.5,18.5,18.5,6,2]
["Ephemerella sp."]
[]
["Whirlgig Beetle","EC50",96,"S,M"," -----","reagent grade",41.2,41.2,41.2,7,2]
["Gyrinus sp. "]
[]
["Oligocheate","EC50",96,"S, M"," -----","reagent grade",41.7,41.7,41.7,8,2,"vii"]
["Lumbriculus variegatus"]
[]
["Red Swamp Crayfish","LC50",96,"SR, U ",268,"reagent grade",59,59,59,9,4]
["Procambarus clarkii"]
[]
["Riffle Beetle","EC50",96,"S, M"," -----","reagent grade",84.9,84.9,84.9,10,2]
["Stenelmis sp. "]
[]
["Flat-headed Mayfly","EC50",96,"S, M"," -----","reagent grade","<108.8",108.8,108.8,11,2]
["McCaffertium sp."]
[]
["Mayfly","LC50",96,"S, M"," -----","reagent grade",122.1,122.1,122.1,12,2]
["Caenis sp."]
[]
["Fathead minnow","EC50",96,"S, M",100,"reagent grade",">500",500,500,13,1,"ii"]
["Pimephales promelas"]
[]
["Isopod","EC50",96,"S, M"," -----","reagent grade",537.2,537.2,537.2,14,2,"viii"]
["Caecidotea sp. "]
[]
["Water Flea","EC50",48,"S, U",136,"reagent grade",">119",{"v":27247.83250161643,"d":"27247.8"},{"v":27247.83250161643,"d":"27247.8"},15,7,"iv"]
["Daphnia magna","EC50",48,"S, M",100,"reagent grade",">500",{"$nulls":3},1]
[null,"EC50",48,"S, M",250,"reagent grade",">340000",{"$nulls":3},5]
[]
["Water Flea","EC50",96,"S, M"," -----","reagent grade",">100000",100000,100000,16,2]
["Ceriodaphnia dubia"]
[]
["Bluegill","LC50",96,"S, M",129,"reagent grade",">117000",117000,117000,17,6,"iii"]
["Lepomis macrochirus"]
[]
["CHRONIC DATA 5"]
[]
[{"$nulls":3},"Study"]
[null,"Test type","Duration","Conditions","Hardness","Test","MATC ","SMCV","GMCV",null,null,"LC/EC50 of paired study","Species ACR"]
["Species","(ELS, etc.)","(days)","(FT,M etc.)","mg/L","Chemical","ug/L","ug/L","ug/L","Rank","Most Sensitive Endpoint",null,null,"Reference(s)"]
["Bloodworm / Midge","ELS",56,"SR, M"," -----","reagent grade",{"v":0.44899888641287294,"d":"0.4490"},{"v":0.44899888641287294,"d":"0.4490"},{"v":0.44899888641287294,"d":"0.4490"},1,"emergence",3.4,{"v":7.572401854185358,"d":"7.6"},"2,8"]
["Chironomus dilutus"]
[]
["Mayfly","ELS",32,"SR, M"," -----","reagent grade",{"v":1.2904650324592295,"d":"1.290"},{"v":1.2904650324592295,"d":"1.290"},{"v":1.2904650324592295,"d":"1.290"},2,"emergence",{"v":3.5,"d":"3.50"},{"v":2.7122005726339413,"d":"2.7"},"2,8"]
["Neocloeon triangulifer"]
[]
["Water Flea","FLC",7,"SR, M"," -----","reagent grade",{"v":8838.834764831843,"d":"8838.8"},{"v":8838.834764831843,"d":"8839"},{"v":8838.834764831843,"d":"8839"},3,"reproduction",100000,"11.3c","2,9"]
["Ceriodaphnia dubia"]
[]
[{"$nulls":11},"geomean ACR:",{"v":7.176995168376474,"d":"7.2"}]
["FLC=Full life cycle (larval through reproduction)",{"$nulls":10},"FCV:",{"v":0.08126699726187643,"d":"0.0813"}]
["ELS = Larval through emergence (no reproduction)"]
[]
["a - organisms fed, but study included based on best professional judgement"]
["b - study not included in calculations, EC50 preferable to LC50 pursuant to Rule 57 midge guidance"]
["c - cannot use c. dubia EC50 since based on > value may be underconservative"]

{"sheet":"Clothianidin References","index":3,"n_rows":10,"n_cols":2,"rows_kept":10,"flags":["formulas_cached_only"]}
["Ref No","Citation"]
[1,"De Perre,C., T.M. Murphy, and M.J. Lydy. Fate and Effects of Clothianidin in Fields Using Conservation Practices. Environ. Toxicol. Chem.34(2): 258-265, 2015. ECOREF #173368"]
[2,"Raby, M., Nowierski, M., Perlov, D., Zhao, X., Hao, C., Poirier, D.G., Sibley, P.K., 2018. Acute toxicity of 6 neonicotinoid insecticides to freshwater invertebrates. Environ. Toxicol. Chem. 37, 1430–1445. https://doi.org/10.1002/etc.4088"]
[3,"Maloney, E.M., Morrissey, C.A., Headley, J. V., Peru, K.M., Liber, K., 2017. Cumulative toxicity of neonicotinoid insecticide mixtures to Chironomus dilutus under acute exposure scenarios. Environ. Toxicol. Chem. 36, 3091–3101. https://doi.org/10.1002/etc.3878"]
[4,"Barbee,G.C., and M.J. Stout. Comparative Acute Toxicity of Neonicotinoid and Pyrethroid Insecticides to Non-Target Crayfish (Procambarus clarkii) Associated with Rice-Crayfish Crop Rotations. Pest Manag. Sci.65(11): 1250-1256, 2009. ECOREF #120043"]
[5,"Takacs,E., S. Klatyik, M. Mortl, G. Racz, K. Kovacs, B. Darvas, and A. Szekacs. Effects of Neonicotinoid Insecticide Formulations and Their Components on Daphnia magna - the Role of Active Ingredients and Co-Formulants. Int. J. Environ. Anal. Chem.97(9): 885-900, 2017. ECOREF #183942"]
[6,"Palmer, S, MacGregor J., Krueger, H. TI-435 Technical: A 96-Hour Static Acute Toxicity Test with Bluegill (Lepomis macrochirus). Bayer Corporation. EPA OPP Database Reference ???"]
[7,"Palmer, S., MacGregor J., Krueger H. TI-435 Technical: A 48-Hour Static Acute Toxicity Test with the Cladoceran (Daphnia magna). Bayer Corporation. EPA OPP Database Reference  ???"]
[8,"Raby, M., Zhao, X., Hao, C., Poirier, D.G., Sibley, P.K., 2018. Chronic toxicity of 6 neonicotinoid insecticides to Chironomus dilutus and Neocloeon triangulifer. Environ. Toxicol. Chem. 37, 2727–2739. https://doi.org/10.1002/etc.4234"]
[9,"Raby, M., Zhao, X., Hao, C., Poirier, D.G., Sibley, P.K., 2018. Relative chronic sensitivity of neonicotinoid insecticides to Ceriodaphnia dubia and Daphnia magna. Ecotoxicol. Environ. Saf. 163, 238–244. https://doi.org/10.1016/j.ecoenv.2018.07.086"]

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["Rule 57 Aquatic Values Data Sheet"]
[{"$nulls":7},"ug/L"]
["Chemical or product name:  Thiamethoxam",null,null,"Developed by:   Sara Nedrich",null,null,"FAV*: ",{"v":1.0576923076923077,"d":"1.06"},null,null,"(Tier: II)"]
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[{"$nulls":3},"CAS, AQUIRE, QSAR: ",null,null,"      Acute CF: 5.2",null," Chronic CF: ----"]
[{"$nulls":3},"Literature Search Date: January 26, 2022"]
[]
[]
[{"$nulls":4},"ACUTE DATA 1"]
[]
[null,"Endpoint","Duration","Test Type","Hardness","Test","LC50/EC50","SMAV","GMAV"]
["Species","(EC or LC50)","(hours)","(FT,M, etc.)","mg/L","Chemical","ug/L","ug/L","ug/L","Rank","Reference","Org requirment filled?","missing:","i, iii"]
["Mayfly","EC50",96,"S, M"," -----","reagent grade",5.5,5.5,5.5,1,1,"vi"]
["Neocloeon triangulifer"]
[]
["Whirligig Beetle","EC50",96,"S, M"," -----","reagent grade",14,14,14,2,1]
["Gyrinus sp."]
[]
["Mayfly","EC50",96,"S,M"," -----","reagent grade","<23.3",23.3,23.3,3,1]
["Caenis sp."]
[]
["Mayfly","EC50",96,"S, M"," -----","reagent grade",44.1,{"v":24.847535089018386,"d":"24.8"},{"v":24.847535089018386,"d":"24.8"},4,1]
["Cloeon sp.","EC50",48,"S, M"," -----","reagent grade",14,{"$nulls":3},2]
[]
["Burrower Mayfly","EC50",96,"S, M"," -----","reagent grade",35.8,35.8,35.8,5,1]
["Hexagenia sp."]
[]
["Chironomus sp. (Bloodworm/midge)",{"$nulls":10},"viii"]
["Chironomus dilutus","EC50",96,"S, M"," -----","reagent grade",36.8,{"v":41.46213607422726,"d":"41.5"},{"v":47.75115147709415,"d":"47.8"},6,1]
["Chironomus dilutus","LC50",96,"S, M",111,"reagent grade",{"v":55.34,"d":"55.3"},{"$nulls":3},3]
["Chironomus riparius","EC50",48,"S, M",127,"reagent grade",35,{"v":54.994090591626296,"d":"55.0"},null,null,2]
["Chironomus riparius","EC50",96,"S, M",150,"reagent grade",{"v":86.41,"d":"86.4"},{"$nulls":3},4]
[]
["Spiny-crawler Mayfly","EC50",96,"S, M"," -----","reagent grade","<59",59,59,7,1]
["Ephemerella sp."]
[]
["Flat-headed Mayfly","EC50",96,"S, M"," -----","reagent grade",81.7,81.7,81.7,8,1]
["McCaffertium sp."]
[]
["Riffle Beetle","EC50",96,"S, M"," -----","reagent grade",148,148,148,9,1]
["Stenelmis sp. "]
[]
["Seed Shrimp","EC50",48,"S, M"," -----","reagent grade",{"v":180,"d":"180.0"},{"v":180,"d":"180.0"},{"v":180,"d":"180.0"},10,2]
["Ostracoda"]
[]
["Amphipod / Freshwater Scud","EC50",96,"S, M"," -----","reagent grade",391,391,391,11,1,"v"]
["Hyalella azteca"]
[]
["Louisiana crawfish","EC50",96,"S, M"," -----","reagent grade",2300,{"v":1491.3416778190033,"d":"1491.3"},{"v":1491.3416778190033,"d":"1491.3"},12,2]
["Procambarus clarkii","EC50",96,"S, U",268,"reagent grade",967,{"$nulls":3},5]
[]
["Oligocheate","EC50",96,"S, M"," -----","reagent grade",2035,2035,2035,13,1]
["Lumbriculus variegatus"]
[]
["Isopod","EC50",96,"S, M"," -----","reagent grade",4775.4,4775.4,4775.4,14,1]
["Caecidotea sp."]
[]
["Chaoborus sp. (Glassworms/midge)"]
["Chaoborus sp.","EC50",48,"S, M"," -----","reagent grade",5500,{"v":6336.402764976355,"d":"6336.4"},{"v":6336.402764976355,"d":"6336.4"},15,2]
["Chaoborus cristallinus","EC50",48,"S, M"," -----","reagent grade",7300,{"$nulls":3},2]
[]
["Water flea","LC50",48,"S, M"," -----","reagent grade",">80000",80000,80000,16,1,"iv"]
["Ceriodaphnia dubia"]
[]
["Rotifer","EC50",24,"S, M","60-120","reagent grade",">100000",100000,100000,17,2,"vii"]
["Brachionus calyciflorus"]
[]
["Water flea","EC50",48,"S, M",270,"reagent grade",">105800",115459.08366170243,{"v":115459.08366170243,"d":"115459"},18,2]
["Daphnia magna","EC50",48,"S, M",250,"reagent grade",126000,{"$nulls":3},6]
[]
["Bluegill","LC50",96,"S, M",124,"reagent grade",">114000",114000,114000,19,2,"ii"]
["Lepomis macrochirus"]
[]
[]
["CHRONIC DATA 5"]
[]
[{"$nulls":3},"Study"]
[null,"Test type","Duration","Conditions","Hardness","Test","MATC ","Most Sensitive Endpoint","LC/EC50 of paired study","Species ACR"]
["Species","(ELS, etc.)","(days)","(FT,M etc.)","mg/L","Chemical","ug/L",{"$nulls":3},"Genus ACR","Rank","Reference(s)"]
["Chironomus sp. (Bloodworm/midge)"]
["Chironomus dilutus","FLC",56,"S, M"," -----","reagent grade",{"v":17.53624817342638,"d":"17.5"},"emergence",36.8,{"v":2.0985104473923344,"d":"2.1"},{"v":3.787264350108317,"d":"3.8"},1,"1, 7"]
["Chironomus riparius","PLS",28,"S, M",150,"reagent grade",{"v":8.261355820929152,"d":"8.3"},"emergence",{"v":86.41,"d":"86.4"},{"v":10.459542219582245,"d":"10.5"},null,null,4]
["Chironomus riparius","PLS",30,"S, M"," -----","reagent grade",{"v":14.142135623730951,"d":"14.1"},"emergence",35,{"v":2.4748737341529163,"d":"2.5"},null,null,2]
[{"$nulls":11}," "]
["Mayfly","PLS",32,"S, M"," -----","reagent grade",{"v":2.2627416997969525,"d":"2.3"},"emergence",{"v":5.5,"d":"5.50"},{"v":2.4306795603287568,"d":"2.4"},{"v":2.4306795603287568,"d":"2.4"},null,"1, 7"]
["Neocloeon triangulifer"]
[]
["Glassworm midge","PLS",34,"S, M"," -----","reagent grade",{"v":905.0966799187809,"d":"905.1"},"emergence",5500,{"v":6.076698900821892,"d":"6.1"},{"v":6.076698900821892,"d":"6.1"},null,2]
["Chaoborus sp."]
[]
[{"$nulls":9},"geomean ACR:",{"v":3.824491342701962,"d":"3.8"}]
["FLC=Full life cycle (larval through reproduction)",{"$nulls":8},"FCV:",{"v":0.27655764202751715,"d":"0.2766"}]
["PLS=Partial life stage, Larval through emergence (no reproduction)"]
[]
[]
["a - study used unmeasured concentrations in their LC/EC50 derivation, but tested a few chambers and verified that measured and unmeasured concentrations were not statistically different"]
["b - measured tests are prefered to unmeasured tests"]
["c - mayfly ACR not used in final FCV calculation due to observed discrepancies with other mayfly data and unusually low value (> magnitude 10 difference from other available ACRs)"]
["d - organisms fed, but study included based on best professional judgement"]

{"sheet":"Thiamethoxam References","index":5,"n_rows":13,"n_cols":2,"rows_kept":13,"flags":["formulas_cached_only"]}
["Ref No","Citation"]
[1,"Raby, M., Nowierski, M., Perlov, D., Zhao, X., Hao, C., Poirier, D.G., Sibley, P.K., 2018. Acute toxicity of 6 neonicotinoid insecticides to freshwater invertebrates. Environ. Toxicol. Chem. 37, 1430–1445. https://doi.org/10.1002/etc.4088"]
[2,"Finnegan, M. C., Baxter, L. R., Maul, J. D., Hanson, M. L., & Hoekstra, P. F. (2017). Comprehensive characterization of the acute and chronic toxicity of the neonicotinoid insecticide thiamethoxam to a suite of aquatic primary producers, invertebrates, and fish. Environmental Toxicology and Chemistry, 36(10), 2838–2848. https://doi.org/10.1002/etc.3846"]
[3,"Maloney, E.M., Morrissey, C.A., Headley, J. V., Peru, K.M., Liber, K., 2017. Cumulative toxicity of neonicotinoid insecticide mixtures to Chironomus dilutus under acute exposure scenarios. Environ. Toxicol. Chem. 36, 3091–3101. https://doi.org/10.1002/etc.3878"]
[4,"Saraiva, A. S., Sarmento, R. A., Rodrigues, A. C. M., Campos, D., Fedorova, G., Žlábek, V., Gravato, C., Pestana, J. L. T., & Soares, A. M. V. M. (2017). Assessment of thiamethoxam toxicity to Chironomus riparius. Ecotoxicology and Environmental Safety, 137(July 2016), 240–246. https://doi.org/10.1016/j.ecoenv.2016.12.009"]
[5,"Barbee, G. C., & Stout, M. J. (2009). Comparative acute toxicity of neonicotinoid and pyrethroid insecticides to non-target crayfish (Procambarus clarkii) associated with rice-crayfish crop rotations. Pest Management Science, 65(11), 1250–1256. https://doi.org/10.1002/ps.1817"]
[6,"Takács, E., Klátyik, S., Mörtl, M., Rácz, G., Kovács, K., Darvas, B., & Székács, A. (2017). Effects of neonicotinoid insecticide formulations and their components on Daphnia magna–the role of active ingredients and co-formulants. International Journal of Environmental Analytical Chemistry, 97(9), 885–900. https://doi.org/10.1080/03067319.2017.1363196"]
[7,"Raby, M., Zhao, X., Hao, C., Poirier, D.G., Sibley, P.K., 2018. Chronic toxicity of 6 neonicotinoid insecticides to Chironomus dilutus and Neocloeon triangulifer. Environ. Toxicol. Chem. 37, 2727–2739. https://doi.org/10.1002/etc.4234"]
[]
["Additional studies (from EPA OPP database) - duplicative to data already included in Finnegan, but pulled some supplemental information from:"]
[null,"Neumann, C. (1996). Acute Toxicity Test of CGA-293343 Technical to the Caldoceran Daphnia magna STRAUS Under Static Conditions: Vol. EPA MRID: https://doi.org/10.32388/usnuy9"]
[null,"Mank, M. A., & Krueger, H. O. (1998). CGA 293343 Technical: A 48-Hour Static Acute Toxicity Test with the Midge (Chironomus riparius): Vol. EPA MRID: https://medium.com/@arifwicaksanaa/pengertian-use-case-a7e576e1b6bf"]
[null,"Drottat, K. R., & Swigert, J. P. (1996). CGA-293343: A 96-Hour Flow-Through Acute Toxicity Test with the Bluegill (Lepomis macrochirus): Vol. EPA MRID 4."]